LOCUS 045_IIG_Bs27_030_SNP 3414542 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1f1-cvskbts VERSION urn.local...1f1-cvskbts KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3414432..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 226633..226634 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_026" CDS 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /modified_by="User" /translation="MQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKTHIIAS GPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAMETRADF AEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFISFHPDV YKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTENGFPYV FTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLSLEQPE YVNQRVLSFLCGGIK*" /label="PG10_pseudo_BSU02260" gene 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /modified_by="User" /label="PG10_pseudo_BSU02260" promotor_-35 226866..226873 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 226882 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 226887..226905 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 227523..227717 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 229489 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 229890..229899 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 229908 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 229912..229927 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 231293 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 231359 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 231362..231381 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 232289..232432 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 232404..232411 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 232425..232444 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 232434 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(233310..233328) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(233327) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(233344..233349) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 233453 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(233492) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(234770..234788) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234779) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234799..234807) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(234807..234825) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234823) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234841..234846) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(234897) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 236642..236661 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 236659 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 237519..237700 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(237547..237617) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(237606..237625) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(237621) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(237641..237648) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 237687..237694 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 237702 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 237707..237726 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 238438..238439 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238455..238469 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238465 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(238564..238582) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(238570) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(238597..238603) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 238773 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 238824..238828 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238844..238863 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238850 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 238861..238989 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 240049 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(240114) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(241510..241621) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(241594..241613) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(241621) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(241628..241635) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(242615..242634) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(242632) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(242649..242656) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(242721) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(245242..245259) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 245247..245266 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(245249) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 245253 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(245275..245282) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 247614 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 247734..247741 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 247746..247863 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 247746 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 247755..247774 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 253155..253162 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 253177..253194 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 253180 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 253862 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 253906 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 255547..255550 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 255565..255584 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 255577..255811 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 255577 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 256734..256741 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 256756..256775 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 256766 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 257005 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 257212..257312 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 257272 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 257360 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 258277..258296 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 258282..258350 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 258282 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(260530..261714) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 261683 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(261759) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(262155..262173) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262174) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(262187..262193) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(262207..263205) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(262250) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 262386..262391 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 262405 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 262407..262425 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262419) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(262421..262435) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(262441) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(262443..262447) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 262850 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 262916..262922 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 262935..262954 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 262937 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(263179..263198) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263205) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263212..263219) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 263626 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 263918..263924 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 263931..263948 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 263942 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(264039..264054) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264045) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264067..264076) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 265962..266021 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(266030) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(267409..267428) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 267422..267428 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(267423) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(267443..267447) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 267443..267462 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 267445 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(267819) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(267822..267841) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(267857..267861) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 268579 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(268634) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(270710..270729) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(270724) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(270744..270751) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 270826..270832 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 270848..270865 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 270854 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 271989 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 272113..272119 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272133..272152 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272133 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 272803 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 272848..273438 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(272879) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(273052,273054) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(273268..273287) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(273275) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(273301..273308) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 273410..273413 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273429..273448 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273440 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 274543 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(274617) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(276283..276302) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(276289) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(276318..276321) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 276339..276342 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 276358..276377 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 276368 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 278355..278363 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 278375..278393 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 278375 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(279413) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(280477..280667) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(280652..280671) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(280672) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(280686..280693) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(282265..282283) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282273) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282297..282304) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 282329..282408 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 282329 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 282331..282337 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 282352..282369 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 283771..284351 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(284282..284363) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 284353 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(284355..284374) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 284356..284375 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(284364) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 285519 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 285566..285572 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 285587..285605 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 285590 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(285639) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 287373..287473 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 287433 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 287499 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 288115 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 288209..288216 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288232..288251 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288238 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 288861..288867 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288881..288900 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288885 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 289237 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 290803 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 291805..291812 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 291827..291846 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 291833..292035 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 291833 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(291881..291900) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(291889) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(291915..291922) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 292019..292028 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 292037..292132 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 292037 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 292041..292056 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 294759 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 297551 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 297631..297638 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 297653..297672 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 297661 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 298881 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(299169) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(300423) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(300680..300699) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(300699) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(300713..300719) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 300946..300965 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 300946 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(300995) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 303955 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(303987) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(304031) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(305164..305251) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 305219..305226 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(305238..305257) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 305241..305260 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(305251) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 305254 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(305270..305276) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 306051..306059 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306071..306089 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306090 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 306728 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 306789..306796 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306811..306830 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306820 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 307256 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 307260..307264 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 307419..307426 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307441..307460 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 307454..307591 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 307454 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 309585 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 309651..309658 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 309668 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 309672..309691 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 310751 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 312357 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(312433) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(313007..313107) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(313047) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 313967..313971 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 313987..314006 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314001 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(314033..314052) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(314036) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(314067..314073) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 314540..314545 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 314561..314579 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314571 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 315244..315253 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315267..315286 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315275 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(315703..316065) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 316061 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(317433..317444) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(317443) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(317459..317465) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 317485..317491 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 317499 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 317506..317517 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 318140..318147 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 318161..318261 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 318161..318180 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 318161 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(318257) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 319062 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(319137) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(319738..319757) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319753) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319772..319775) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(319781..319929) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 319831..319838 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 319851..319870 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 319853..319961 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 319855 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(319923..319941) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 319929..319936 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(319939) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319951..319970 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(319957..319962) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319963 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 320536 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(320611) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(321380..321399) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321381..321388 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321386) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321403..321422 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321414..321419) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321415 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 322441..322511 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 322927..322933 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 322948..322959 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 322955 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 323469..323547 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 323522..323527 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 323544..323562 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 323549 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 324299 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 324344..324471 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 324448..324452 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324467..324486 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324473 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 326424..326430 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326444..326463 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326452 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 326535..326541 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326554..326573 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326563 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 326999..327003 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 327001..327123 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 327003 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(327644..329499) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 328525 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 328570..328666 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 328637..328644 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328659..328678 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328668 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(329492..329510) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(329509) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(329524..329531) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(329917) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(329983) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(331768) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(331773..331786) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(331801..331809) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(332689..332708) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(332709) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(332723..332726) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 332760..332779 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(332760..332778) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 332767..332831 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 332768 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(332777) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(332794..332799) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 333843..336290 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(333878) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 335557..335562 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 335576..335580 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 335583 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(335615) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(335617..335636) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(335650..335657) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(338180..338199) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(338194) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(338211..338217) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(342750..342850) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(342790) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 342833..342840 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 342854..342873 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 342866 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 344101 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 344160..344166 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 344181..344200 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 344189 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 345739..345746 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 345760..345779 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 345770 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 347222 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 347267..348936 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(347285) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(348854..348873) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(348866) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(348868..351702) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(348888..348895) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 348905..348911 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 348926..348944 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 348938..349160 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 348938 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 349129..349134 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 349150..349168 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 349162 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 349640 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 349688..349694 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 349701 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 349708..349719 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 350060 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 350165..350172 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350188..350207 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350192 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 351644 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(352098..352198) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(352138) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(352592..352611) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(352600) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(352602..352744) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(352625..352632) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 352757..352764 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 352775..355918 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 352775 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 352779..352798 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(352780..352880) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(352820) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(354490..354508) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(354505) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(354522..354529) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(354580) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(355798..355817) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(355813) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(355832..355835) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 355896..355899 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 355914..355933 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 355920 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 356352 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 356615..356618 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 356633..356652 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 356641..356941 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 356641 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 383072 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 383128..383135 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 383138 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 383147..383166 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 384411 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(384447..384547) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(384469) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(384487) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(385018..385037) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(385020) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(386020..386038) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(386027) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(386054..386059) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(388136..388155) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(388148) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(388890..388909) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(388893) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(388925..388929) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(389030..389181) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(389238) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(391485..391504) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(391497) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(391518..391525) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(392162..392180) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392169) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(392195..392201) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 392478..392485 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(392493..392512) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 392499..392518 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392499) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 392507 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(392526..392533) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 395238 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 395264..395265 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 395265 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(396217) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 397714..397716 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(397715..397734) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 397725 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 397733..397751 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(397735) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(397737..>397920) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(397749..397756) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 397905..397914 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 397920..397921 /note_="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_011" downshifts 397926 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(398260..398271) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(398266) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(398285..398291) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399418..399437) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 399419..399426 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(399425) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399440..399459 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399444 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399448..399455) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 400670..400676 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400690..400708 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400698 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 400794..400801 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400816..400835 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400825 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 402257 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 402307..402313 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402327..402338 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402328 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 403360..403379 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 403360 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 403448 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 404042 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(404096) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(406966..406985) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(406981) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(406999..407006) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 407066..407085 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 407078 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 407433 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 407526..407533 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 407547..407566 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 407552 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 407562..407634 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 410633 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 410679..410682 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 410698..410717 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 410700 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 410975..410983 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 410997..411016 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411007 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 411799 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 411872..411879 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411892..411911 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411905 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 412504..413228 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(413189..413208) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 413205..413211 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(413212) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 413224..413243 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413230 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 413626 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(413702) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(413856..413874) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413878) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413889..413895) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413908..413915 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413929..413948 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413932 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 414705 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(414781) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 414811..414817 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414831..414850 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 414837..414933 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 414837 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 418996 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 419090..419190 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 419150 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 420276..420285 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 420299..420318 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 420309 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 420969 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(420981..421406) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(421026) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 421059..421065 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421079..421098 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421080 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 421402..421812 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(421715..421734) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(421731) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 421788..421792 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421809..421828 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421814 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 423852..423952 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 424835 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 424928..424935 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424949..424968 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 424953..425040 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 424953 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 427112 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 427154..427160 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427174..427192 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427186 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 427197..427278 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 427240..427247 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427261..427280 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427280 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 428832 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(428901) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(429480..429498) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(429494) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(429513..429519) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 429555..429561 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 429573 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 429576..429594 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 430980 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 431028..431035 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431049..431068 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431051 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 431651..431657 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431672..431690 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431685 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 432141..432149 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432160..432179 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 432179..432545 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 432179 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(432205..432305) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(432245) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 432502 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 432582..432591 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432604..432619 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432609 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 433432 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(433499) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(433813..433832) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 433813..433831 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 433819 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(433829) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 433907..433914 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433928..433947 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 433932 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 434401..434404 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 434413 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 434421..434440 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 436635 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 436701..436707 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 436722..436740 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 436723..436854 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 436723 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 443851 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 443964..443971 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443986..444005 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443993 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 444144 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 444189..444342 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 446158 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 446687..446693 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 446708..446726 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 446709 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(447577..448436) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(448438..448549) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 448449 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(448481) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(448509..448609) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 448518..448523 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448540..448558 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448549) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 448550..448765 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 448550 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(448616..448687) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(448659) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(448970..448989) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448988) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(449001..449008) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(449077) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(450397..450416) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450409) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(450411..450488) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(450429..450436) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(450472..450491) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450488) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(450505..450514) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(450573) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(450639) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(451371..451389) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(451388) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(451403..451409) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 451421 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 451429..451448 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 452279 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 452356..452362 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452376..452394 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452384 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(452421) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 452805 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(452839) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(452842..452845) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 452867..452874 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452886..452905 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452893 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(453317..453610) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 453555 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 453599 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(453655) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(454494..454512) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(454515) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(454526..454532) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 454869..454876 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 454891..455678 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 454891..454910 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454892 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(455622..455641) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(455627) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(455655..455662) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 457957..458031 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 457998..458005 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 458020..458037 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 458033 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 459335 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(459389) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 459426..459443 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 459428 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 460543..460786 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 460743 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 462564..462583 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 462569 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 462910 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 462955..463024 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 462990..462997 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463011..463030 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463025 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 464190 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(464251) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(464413..464581) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(464573..464592) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(464583) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(464607..464614) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 464722..464727 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 464743..464761 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 464747 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 465013..465022 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465035..465050 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 465038 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(465594..465663) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(465637) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 465650..465999 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 465980..465984 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465993..466007 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 466001..466158 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 466001 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(466005..466024) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(466020) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(466038..466045) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 467211 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 468699..468705 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468719..468730 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 468729 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 468772..468791 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 468773..468947 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 468773 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 468915..468922 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468937..468956 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 468949..469016 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 468949 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 470545 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 470665..470724 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 470665..470674 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 470667 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 470686..470701 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 472645 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 472690..473017 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(472699) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 472987..472992 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473005..473024 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 473019..473620 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 473019 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(473550..473569) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(473561) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 473989..473994 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 474010..474151 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 474010..474028 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 474010 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 475153 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 475213..475220 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 475234..475253 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 475241 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 476381..476386 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476401..476419 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476407 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 476482..476485 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476501..476520 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476502 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(476994..477470) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(477037) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 477184 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 477238..477245 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 477259..477278 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 477267 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(477453..477471) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(477470) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(477472..478071) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(477485..477492) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(478060..478078) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478071) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(478073..478661) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(478092..478098) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(478659..478678) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478676) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478692..478701) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 479931..479937 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 479952..479970 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 479958 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 482146 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 482204..482210 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482225..482244 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(482233,482235) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 482237 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 482664..482672 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482684..482703 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 482699 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(482932..485987) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 483535 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 483591..483592 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 483608..483627 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 483608 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 485801..485820 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 485823..486039 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 485823 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(485976..485995) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(485993) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(486010..486018) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 486498..486504 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486519..486538 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 486527..486614 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 486527 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(486559) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 487231 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 487332..487333 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<487333..487639) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 487352 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(487384) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(488335..488354) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488348) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488369..488376) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488448..488452 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488469..488488 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488473 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 488474..488918 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 489330..489399 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 489356 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 491031..491035 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 491052..491071 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 491061 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 493402..493961 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 495191..495195 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 495210..495229 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 495218 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(495265,495267) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 495458 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 496515..496522 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496536..496555 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496547..496664 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 496547 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(496582) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(496763..497551) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 496768 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 496869 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 498022..498567 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(498065) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(498072..498091) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(498107..498114) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 498534 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(499924) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(499928..499947) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(501980..501985) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(501987..501988) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(501992) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 502061..502067 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 502075 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 502081..502100 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 503478 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 504913..504919 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 504934..504953 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 504941 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 504952..505062 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 505538 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 505589..505596 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505611..505630 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 505612 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 506382 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(506458) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 506471..506478 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 506492 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 506493..506512 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(507399..507418) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(507406) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(507430..507435) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 508678..508684 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 508699..508718 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(508700..508719) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 508714 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(508724) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(508734..508741) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 510309..510316 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 510327..510346 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 510341 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 510801..512055 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(510858) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(511426..511506) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(511853..511872) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(511870) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 512044..512063 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 512057 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 512850 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 513048 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(513125) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(513500..513564) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 513552..513559 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(513553..513572) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(513566) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 513573..513592 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 513576 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(513587..513594) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 515670..515674 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 515688 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 515689..515708 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 516612 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 516745..516748 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 516755..516941 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 516755 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 516763..516782 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 519041..519049 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 519060..519078 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 519077 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 519142 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 519890 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(523203..523222) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 523211..523218 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(523222) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 523233..523252 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 523235 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(523237..523243) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 523982 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(524034) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(524495..524514) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(524519) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(524528..524535) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 524828..524830 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524846..524865 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524862 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 526996 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(527029..527048) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(527050) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(527062..527069) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 527110..527115 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 527128 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 527130..527148 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(528194..528212) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(528194) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(529296..529703) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 529313..529317 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 529327 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 529330..529349 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(529341) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(530607..530702) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(530682..530701) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(530702) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(530715..530722) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(532428..532447) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532441) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532463..532470) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(532530) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(533404..533496) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(533477..533496) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(533494) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(533512..533519) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 533685..533692 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 533707..533726 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 533713 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 534223..534229 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 534234 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 534243..534261 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 535441..535444 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535459..535478 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 535466..535554 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 535466 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 535935 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 536058..536077 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 536060..536129 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 536060 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 536456 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(536532) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 536556..536562 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 536577..536588 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 536588 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(536745..536906) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(536910..537275) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(536950) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 537490 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(537527..537546) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537544) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(537546..537629) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(537560..537569) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(538278..538289) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(538292) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(538304..538310) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(538308..539141) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 538323..538328 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 538343..538354 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 538348 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(540136..540155) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(540140) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(540169..540178) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 540333..540340 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 540356..540375 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 540364 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 541342..541503 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 541978..542670 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(542120) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(543815..544012) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 543829..543831 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 543848..543866 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 543852 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(543858) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 543978 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(544004..544023) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(544016) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(544036..544043) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(544099) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(545526..545545) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(545541) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(545615,545617) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 545616..545649 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(545662) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(546192..546211) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546211) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546227..546230) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546248..546255 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546270..546289 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546288 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 546320..546321 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(546859..546870) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546867) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546884..546890) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546945..546952 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546966..546985 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 546968..547068 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 546970 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(547016) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 547028 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 547036..547043 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 547057..547076 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 547072..547159 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 547072 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 552528 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 552632..552636 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 552652..552671 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 552656 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 556312 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(556595) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 558258..558277 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 558268 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 558270..558459 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 558424..558431 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 558445..558464 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 558461..558631 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 558461 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(558526..558545) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(558538) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(558559..558566) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 559618..559718 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 559678 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 560734 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(560809) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 561372..561377 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561392..561410 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 561394 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 561713..561714 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 561724..561738 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 561746 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(561751..561770) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561768..561876 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(561771) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561784..561789) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 561850..561856 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561870..561889 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561878..561952 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 561878 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 563919..564011 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 563968 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 564013..>565239 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(565239,565246) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 565240..565245 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(565366) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567847..567866) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567873) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567880..567887) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 567936..567937 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 567952..568034 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 567952 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 567953..567972 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 570588..570595 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570609..570628 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 570614 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 571603 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 571743..571752 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 571759 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 571765..571780 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 572498..572562 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 575344 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 575388 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(576458..576477) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576476) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576491..576497) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576686..576693 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 576706 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 576708..577010 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 576708..576727 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 578424 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(578480) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 579060..579069 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579083..579102 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 579084..579619 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 579084 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(579521..579815) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 579620..579639 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 579621..579918 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 579621 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(579810..579824) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(579815) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 579917..579936 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579920 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 580316 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 581416 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(581492) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(581691..581823) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(581734) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(582066..582085) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582077) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 582758..582767 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582780..582799 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 582780 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(583798..583816) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583806) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583832..583837) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(583955..583970) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583976) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583982..583991) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(584044) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(585603..585622) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(585617) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(585636..585645) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(585738) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(587174..587193) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(587188) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 587464..587471 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587487..587506 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587488 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 588368 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(588643) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 588697..588716 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 588707 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 593141..593148 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 593163..593182 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 593179..593308 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 593179 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 594836 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 594957..594961 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 594977..594996 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 594987 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 595122 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 596531 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 596574 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 596603..596612 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 596623..596763 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 596623 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 596625..596640 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 597552 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 597635..597642 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597656..597675 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597662..597725 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 597662 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 597900 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 597944..597950 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597965..597983 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597968..598054 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 597968 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 598033..598040 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598054..598073 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598056 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 598848 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 598904..598911 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598926..598945 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598928 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 599041..599180 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(601106..601125) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(601127) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(601140..601147) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(604054) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 607441..607541 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 608589..608603 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 608598 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(608865..608883) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608872) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(608899..608904) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 611970 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(612514..612533) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(612523) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 613811 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(613888) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(614105..614525) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 614172..614177 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 614188 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 614191..614210 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(614510..614521) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(614525) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(614535..614541) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 614556 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 615949..615955 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 615967 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 615968..615987 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 617177 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 617319 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(617363) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(618940..618959) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(618959) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(618974..618980) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 619123..619126 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 619140 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 619143..619162 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(624399..624403) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(624403) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 625431..625450 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 625439..625555 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 625439 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(625503) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(625573..625673) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(625613) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 626549 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 626593..627397 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(626625) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(627322..627340) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(627343) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(627356..627361) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(627423) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(628275) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(628278..628291) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(628888..629018) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(629009..629027) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(629018) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(629042..629048) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 629149..629152 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 629167..629300 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 629167 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 629169..629188 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 632489 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(632565) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 633182..633187 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 633203..633221 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 633215 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(633393..633467) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 633445..633452 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(633461..633480) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 633467 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 633468..633487 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(633474) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(633495..633502) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 636669 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 636921..636924 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636939..636958 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636947 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 637917..638171 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" CDS 639521..639700 /created_by="User" /locus_tag="PG10_rand_003" /modified_by="User" /transl_table=11 /pseudo /translation="MLCVDKIKRINSQKSMLMELLVRARMIFSATASRCRKQPQERKY VNWRHLQCVRRIGAN*" /label="PG10_rand_003" gene 639521..639700 /locus_tag="PG10_rand_003" /created_by="User" /label="PG10_rand_003" S_feature 639552..>639587 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" SCAR join(639587,639594) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_030" N_region 639588..639593 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27_030" CDS 639622..640506 /gene="cypD" /locus_tag="PG10_pseudo_BSU_07250" /old_locus_tag="BSU_07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /modified_by="User" /translation="MQEAATRAQIRELASFTVCPPHRRELEELSAEGVYQEQILKKRI SMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQASITVGVVRGPAWSG RGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMVGPGTGVAPFRGFL QARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTVHTAFSRKEGMPKT YVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQAVHGTGEQEAQNW LRHLQDTGMYAKDVWAGI*" /label="PG10_pseudo_BSU_07250" gene 639622..640506 /gene="cypD" /locus_tag="PG10_pseudo_BSU_07250" /old_locus_tag="BSU_07250" /modified_by="User" /label="PG10_pseudo_BSU_07250" downshifts 640493 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 640556..640561 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640577..640595 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 640598 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 640626..640629 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640646..640665 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 640647..640952 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 640647 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 640953..642872 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 640953..642872 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 642871 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 642960..642969 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 642979..643107 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 642979 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 642983..643002 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(643033) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 643108..643872 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 643108..643872 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 643879..644847 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 643879..644847 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 644871..645782 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 644871..645782 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 645660..645669 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 645682..645701 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 645685 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 645811..646989 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 645811..646989 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 646530..646536 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646551..646570 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 646565 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 646990..647925 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 646990..647925 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 647797 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 647907 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(647948) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(647956..649185) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(647956..649185) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(649214..649233) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(649232) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(649249..649256) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(649296..650003) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(649296..650003) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(649325) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(650026..650045) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(650049) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(650095..651480) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(650095..651480) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(650117) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(651529..651548) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(651546) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(651563..651570) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 651648..651655 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 651663 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 651669..651687 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 651730..653187 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 651730..653187 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(652523..652542) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(652537) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(652555..652564) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 653201..654061 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 653201..654061 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 654045 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 654129..654136 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 654150..654169 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 654155 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 654196..656085 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 654196..656085 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 656069 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 656149..656168 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 656157 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 656208..656654 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 656208..656654 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(656210) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(656294..656297) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(656299) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(656315..656316) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 656641 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 656717..656724 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 656738..656757 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 656750 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 656779..657201 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 656779..657201 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 657037 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 657267..658457 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 657267..658457 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(658521) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 658748..658903 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 658748..658903 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(659023..660579) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(659023..660579) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(659047) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 660409..660415 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660430..660441 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660447 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(660629..660648) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(660633) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(660664..660668) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 660689..660692 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660708..660727 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660711 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 660752..661882 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 660752..661882 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 661865 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 661950..662396 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 661950..662396 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(662449..663468) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(662449..663468) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(662459) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(663489..663508) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663493) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(663495..663949) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(663521..663528) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 663587..663594 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 663608..663627 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 663615..664712 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 663615 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(663950..665170) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(663950..665170) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(665207..665226) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(665214) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665242..665249) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 665268..665275 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 665287..665462 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 665287 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 665290..665309 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 665419 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 665506..666969 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 665506..666969 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(665871..667541) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 666970..667463 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 667451..667456 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 667465..670730 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 667465 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 667472..667490 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(667542..668342) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(667542..668342) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(668355..669356) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(668355..669356) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(668942..668961) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(668954) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(668976..668983) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(669353..670354) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(669353..670354) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(670424..670443) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(670426..671373) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(670426..671373) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(670445) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(670445) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 670700..670705 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 670721..670739 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 670732..671357 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 670732 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 671353..671372 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 671359..671890 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 671359 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(671415..671434) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(671422) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(671448..671455) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(671482..671850) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(671482..671850) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(671851..671963) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(671952..671971) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(671963) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(671983..671990) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 672031..672037 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 672051..672069 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 672051 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 672094..672441 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 672094..672441 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(672095) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 672437 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 672482..672562 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 672563..672582 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 672564 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 672632..673894 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 672632..673894 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 673889 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 673947..673950 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 673965..673984 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 673973 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 674021..675457 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 674021..675457 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 675449 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 675548..675567 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 675559 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 675584..677212 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 675584..677212 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 677184..677864 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 677184..677864 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 677867..678826 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 677867..678826 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 678795 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 678918..678925 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678938..678957 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 678949..679021 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 678949 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 679022..680323 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 679022..680323 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 680320..680326 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680340..680351 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680341 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 680379..681173 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 680379..681173 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 681149 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 681228..681231 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 681246..681265 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 681259 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 681292..682383 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 681292..682383 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(682374..682649) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(682374..682649) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 682384..682715 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(682663..682682) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682677) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(682697..682704) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 682716..683381 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 682716..683381 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(683422..683559) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(683422..683559) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(683436) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(683560..683690) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(683676..683694) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 683686..683691 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(683690) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 683701..684765 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 683702 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 683707..683725 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(683710..683715) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(683716..683871) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(683716..683871) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(683872..683977) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(683978..684292) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(683978..684292) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(684293..684373) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(684374..685123) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(684374..685123) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(685152..685171) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(685165) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(685167..686303) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(685183..685191) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 685234..685235 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685255..685274 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685258 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 685295..686653 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 685295..686653 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(686289..686308) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(686303) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(686322..686331) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 686539 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 686649 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(686686..688635) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(686686..688635) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(686703) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 687745..687751 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 687767..687785 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 687771..688735 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 687771 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(688636..688710) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(688687..688706) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(688710) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(688712..689234) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(688722..688726) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 688736..688873 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 688736..688873 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 688851 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 688852..688871 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 688892..689284 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 688892..689284 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(689232..689250) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(689247) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(689266..689271) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 689353..689359 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 689374..689392 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 689374 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 689409..690824 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 689409..690824 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(689410) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(689436..689536) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(689476) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(690821..691897) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(690821..691897) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 690825..694191 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(691921..692121) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(691921..692121) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(692137..693291) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(692137..693291) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(693272..694813) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(693272..694813) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(694863..694874) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(694866) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(694888..694894) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 694923..694930 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 694945..694964 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 694952 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(694998) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 695006..696418 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 695006..696418 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(695024..695124) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(695064) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 696489..698174 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 696489..698174 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(696795..696810) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(696802) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(696823..696832) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 698147..698151 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698167..698186 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 698170 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 698195..698911 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 698195..698911 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 698904 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 698986..698989 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 699005..699024 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 699014 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 699051..699716 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 699051..699716 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 699697 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(699753..704141) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(699753..704141) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(699772) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(704174..704193) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(704191) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(704208..704211) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 704318..704324 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 704338..704356 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 704341 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 704384..704902 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 704384..704902 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 704888 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(704932) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 704933..706583 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(704942..706132) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(704942..706132) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(706133..706224) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(706225..706440) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(706225..706440) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(706284) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(706472..706491) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(706486) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(706506..706507) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 706553..706560 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706575..706594 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706585 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 706643..707113 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 706643..707113 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 707131..707451 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 707131..707451 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 707475..708302 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 707475..708302 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 708281..708287 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 708302..708313 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 708320..708476 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 708320 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(708352) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 708451 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(708501..709676) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(708501..709676) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(708506) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 709113..709119 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 709135..709153 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 709139..709792 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 709139 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(709701..709720) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709716) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709734..709741) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 709782..709787 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 709794 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 709802..709820 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 709844..710899 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 709844..710899 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 710913..710919 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 710934..710945 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 710938 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 710970..711764 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 710970..711764 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 711752 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(711803..712645) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(711803..712645) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(711805) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(712646..713767) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(712646..713767) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(713808..713827) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(713826) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(713843..713847) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 713855..713862 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 713876..713895 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 713886 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 713912..714097 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 713912..714097 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 714076 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 714140..714146 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 714152 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 714161..714172 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 714198..714989 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 714198..714989 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 714987 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(715027..715887) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(715027..715887) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(715041) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(715907..715926) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(715921) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(715942..715945) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(715986..716945) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(715986..716945) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(716009) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(716956..716975) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716959) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716991..716994) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 717006..717010 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 717024..717043 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 717033 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 717064..717927 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 717064..717927 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 717928..718040 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 718041..719441 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 718041..719441 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 719453 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 719747..719754 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 719770..719789 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 719776 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 719783..720066 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 720067..720333 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 720067..720333 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(720281..720300) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(720299) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(720315..720318) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 720334..720815 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 720786..720789 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720806..720825 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 720817..721064 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 720817 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 721065..722042 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 721065..722042 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 722043..722135 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 722092 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 722176..722182 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 722194..722213 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 722203 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 722238..722690 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 722238..722690 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 722720..723409 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 722720..723409 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 723414 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 723586..723604 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 723593 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 723641..724642 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 723641..724642 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 724646..725674 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 724646..725674 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 725688..726884 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 725688..726884 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(725689) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 726905..728281 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 726905..728281 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 728275 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 728328..728335 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 728348..728367 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 728356 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 728397..730214 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 728397..730214 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 730215..730221 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 730233 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 730236..730247 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 730268..730447 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 730268..730447 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 730431 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(730483..730812) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(730483..730812) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(730497) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(730862..731320) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(730862..731320) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(731321..731413) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(731414..731971) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(731414..731971) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 731837..731842 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 731850 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 731857..731875 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 731861..732448 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(732003..732770) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(732003..732770) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(732782..734005) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(732782..734005) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(734011..734325) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(734011..734325) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(734373..734392) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(734386) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(734407..734410) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 734617..734636 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 734620 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 734661..736010 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 734661..736010 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 736039..736058 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 736041 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 736075..736839 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 736075..736839 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(736219..736233) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(736249..736255) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(736249) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 736854..738437 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 736854..738437 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 738417 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 738466..738473 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 738488..738507 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 738496 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 738543..740264 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 738543..740264 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 740258..742072 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 740258..742072 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 742047 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 742154..742161 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742175..742194 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742179 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 742227..742631 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 742227..742631 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 742649..743506 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 742649..743506 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 743493 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 743600..744544 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 743600..744544 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(744411) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(744459..744559) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(744499) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 744719..746167 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 744719..746167 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 746194..747135 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 746194..747135 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 747145..748326 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 747145..748326 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 748316 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 748386..748392 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 748407..748426 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 748425 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 748450..749652 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 748450..749652 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 749649..750311 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 749649..750311 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 750319 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 750455..751390 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 750455..751390 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 751403..752593 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 751403..752593 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 752607..753764 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 752607..753764 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 752718..752723 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 752738..752756 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 752739 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(753762..753836) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(753805) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(753837..754385) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(753837..754385) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(754386..754465) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(754454..754473) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754465) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754487..754492) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 754588..754591 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 754607..754626 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 754614 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 754658..755290 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 754658..755290 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 755269 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 755405..755410 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 755424..755443 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 755434 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 755479..756567 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 755479..756567 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(755969..756357) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(756357) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(756359..756378) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(756391..756399) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(756603..757220) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(756603..757220) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(756621) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(757186..758439) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(757186..758439) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(757247..757266) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(757259) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(757280..757287) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(758473..758492) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(758491) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(758507..758514) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 758518..758537 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 758523 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 758563..759099 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 758563..759099 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(759096..760652) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(759096..760652) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(760674..760692) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(760691) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(760708..760711) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(760763..761245) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(760763..761245) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(760779) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761270..761289) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761286) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761304..761310) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 761331..761338 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761352..761371 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761360 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 761417..763987 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 761417..763987 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 763958 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(764005..764982) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(764005..764982) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(764016) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 764997..765004 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(765009..765028) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 765019..765038 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 765021..765112 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 765021 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(765026) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765043..765050) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 765113..766114 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 765113..766114 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 766111..767142 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 766111..767142 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 767123 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 767193..767195 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 767211..767230 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 767214 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 767257..768138 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 767257..768138 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 768149..768156 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768172..768191 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768181 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 768226..768810 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 768226..768810 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 768797 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(768849..769040) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(768849..769040) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(768867) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(769072) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(769075..769086) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(769101..769107) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(769107..769217) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(769107..769217) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(769246..769257) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(769248) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(769272..769278) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(769272..770183) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(769272..770183) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 770069..770072 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 770089..770108 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 770099..770271 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 770099 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(770205..770223) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(770219) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(770237..770243) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 770272..771066 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 770272..771066 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 771068..771382 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 771068..771382 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(771290..771558) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 771372 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 771456..771461 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 771477..771496 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 771482 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 771525..772718 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 771525..772718 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 772719..772953 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(772751..772903) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(772751..772903) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(772768) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 772932..772939 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 772953..772972 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 772955..773027 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 772955 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(772962..772973) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(772972) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(772988..772994) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 773028..773297 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 773028..773297 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 773286 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 773375..773381 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 773396 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 773397..773415 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 773442..773960 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 773442..773960 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 773961..774028 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 773996..774005 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 774017..774032 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 774030 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 774045..774377 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 774045..774377 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 774364..775224 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 774364..775224 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 775222 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 775282..775288 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775302..775313 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 775310..775374 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 775310 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(775332..775351) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(775341) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 775357..775363 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(775365..775366) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 775376..775456 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 775376 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 775378..775396 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 775457..776446 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 775457..776446 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(775606) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(775611..775615) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(775632..775636) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 776447..776517 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 776518..779103 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 776518..779103 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 779072 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(779096..780079) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(779096..780079) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(779130) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 779553..779562 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 779575..779594 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 779579 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(780080..780227) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 780184..780188 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 780204..780223 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 780211 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 780217..780294 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(780225..780244) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(780227) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(780259..780266) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 780295..781404 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 780295..781404 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 781241..781245 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 781261..781280 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 781273 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 781405..781717 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(781412..781636) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(781412..781636) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(781666..781677) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(781668) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(781691..781697) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 781718..782470 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 781718..782470 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 782487..782493 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 782508..782519 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 782509 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(782516..782530) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(782537) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(782539..782543) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 782539..782793 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 782539..782793 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 782791 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(782816) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 782882..783226 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 782882..783226 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 782889..782897 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 782908..782926 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 782910 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 783209 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 783265..783272 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783286..783305 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 783295..783369 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 783295 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 783370..783900 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 783370..783900 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 783891 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 783988..785730 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 783988..785730 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 785717 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(785807..786868) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(785807..786868) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(785818) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(786869..786959) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(786957..786976) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786966) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(786991..786998) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(787088..788377) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(787088..788377) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(787091) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(788405..788424) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(788424) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(788426..789137) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(788436..788441) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 788470..788477 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 788491..788510 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 788491 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 788530..789003 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 788530..789003 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 789040..789047 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 789062..789081 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 789068 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 789126..789563 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 789126..789563 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 789545 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(789598..789951) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(789598..789951) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 789611 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(789621) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 789947..789951 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 789959..789973 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(789963..789982) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 789963..790054 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 789963 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(789973) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 790031..790034 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 790049..790068 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 790056..790158 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 790056 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 790159..791043 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 790159..791043 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 791026..791033 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 791047..791066 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 791062..791334 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 791062 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(791095) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 791335..792889 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 791335..792889 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 793057..795984 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 793057..795984 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 795985..796070 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 796046..796053 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796067..796086 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796072 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 796096..796211 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 796096..796211 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 796221..796295 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 796221..796295 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 796301..796392 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 796301..796392 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 796388 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 796427..796498 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 796427..796498 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 796508..796583 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 796508..796583 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 796593..796669 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 796593..796669 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 796681..796757 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 796681..796757 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 796770..796845 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 796770..796845 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 796851..796923 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 796851..796923 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 796946..797030 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 796946..797030 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 797036..797109 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 797036..797109 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 797134..797209 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 797134..797209 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 797219..797290 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 797219..797290 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 797340..797414 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 797340..797414 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 797420..797490 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 797420..797490 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 797498..797586 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 797498..797586 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 797587..797663 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 797620 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 797665..797833 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 797790..797797 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 797796 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 797811..797830 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 797835 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 797852..797933 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 797852..797933 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(797869..797886) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(797872) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(797907..797912) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(797942) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(798012..798788) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(798012..798788) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(798026) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(798815..798830) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(798837) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(798843..798852) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 798872..798878 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 798893..798904 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 798896 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 798930..799133 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 798930..799133 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 799116 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(799192) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(799218..799490) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(799218..799490) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(799449..799467) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799456) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 799471..799478 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(799484..799489) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799491..799510 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 799499 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 799532..800224 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 799532..800224 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 800253..800257 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(800256..800275) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(800268) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 800271..800290 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(800290..800297) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 800294..800401 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 800294..800401 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 800301 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 800432 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 800534..802306 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 800534..802306 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 802282 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 802327..803252 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(802344..803699) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(802344..803699) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(803727..803746) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(803744) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(803760..803769) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 803817..803823 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803838..803857 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803866 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 803950..804147 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 803950..804147 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(804174..805625) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(804174..805625) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(804184) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 805602..805608 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 805623..805642 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 805626 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(805643..805662) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 805648..805977 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(805662) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(805676..805683) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(805721..805739) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(805746) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 805934 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 806033..806800 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 806033..806800 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 806818..807816 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 806818..807816 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 807813..808643 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 807813..808643 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 808666..809796 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 808666..809796 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 809823..809842 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 809829 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 809900..810436 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 809900..810436 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 810437..810507 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 810477..810484 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 810498..810517 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 810509 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 810548..810817 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 810548..810817 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 810620..810624 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 810647..810663 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 810663 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 810804 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(810835..811308) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(810835..811308) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(810871) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(811310..811510) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(811310..811510) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(811539..811558) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811553) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(811571..811578) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 811634..811639 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811653..811672 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811653 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 811704..811777 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 811704..811777 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 811778..811960 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(811868..812491) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(811868..812491) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(811883) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 811917 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 811962..812573 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(812515..812534) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(812536) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(812548..812555) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 812574..813734 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 812574..813734 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 813743 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 813760..813772 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 813765 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 813801..814736 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 813801..814736 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(813819) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 814720..814723 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 814738 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 814739..814758 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 814774..815256 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 814774..815256 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 815239 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 815306..816022 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 815306..816022 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 815326..815333 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815348..815367 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815349 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 816013..816726 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 816013..816726 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 816738..817445 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 816738..817445 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 817329 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 817373 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 817439 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(817472..817647) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(817515) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(817639..817658) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(817647) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(817673..817680) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 817712..817717 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 817733..817751 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 817733 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 817795..819690 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 817795..819690 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 818237..818337 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 818297 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 818363 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 819683 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 819747..819752 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 819768..819786 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 819771..819869 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 819771 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 819870..821048 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 819870..821048 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 820068..820071 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 820086..820105 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 820090 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(820331) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 821027 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 821135..821142 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821157..821176 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821157 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 821208..821672 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 821208..821672 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 821497..821503 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821518..821536 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821531 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 821681..821687 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821701..821712 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821707 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 821708..822373 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 821708..822373 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 822414..824012 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 822414..824012 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 824035..824565 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 824035..824565 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 824578..824952 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 824578..824952 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 824941 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 824952..825107 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 824952..825107 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 825042..825048 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825063..825082 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 825073 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 825112..825873 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 825112..825873 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(825425..825443) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825439) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825459..825464) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 825876..826241 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 825876..826241 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 826243..826941 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 826243..826941 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 826958..827875 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 826958..827875 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 827868..828809 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 827868..828809 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 828791 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(828901..829104) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(828901..829104) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(828915) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(829105..829232) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 829192..829203 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 829209 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(829221..829240) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(829232) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(829234..830372) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(829254..829259) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 829399..829406 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 829421..829439 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 829428 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 829429..829539 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 829540..830370 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 829540..830370 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 830329 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(830373..831452) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(830373..831452) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(831462..831481) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(831483) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(831497..831501) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 831559..831566 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 831580..831599 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 831586 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 831625..833016 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 831625..833016 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(832652..833055) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 832995 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(833056..833511) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(833056..833511) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(833526..833544) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(833554) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(833559..833565) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 833603..833609 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 833623..833634 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 833627 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 833661..834230 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 833661..834230 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 833857..833863 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 833874 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 833877..833888 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 834205 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 834273..834282 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834296..834315 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 834306 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 834351..835319 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 834351..835319 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 835195 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(835251..835904) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(835251..835904) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(835268) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(835935..835946) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(835937) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(835961..835967) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 835976..835984 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 835987..839640 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 835987..839640 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 835995..836013 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836010 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 839637..840233 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 839637..840233 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 840212 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(840263..841171) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(840263..841171) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 841227..841235 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(841228..841239) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(841234) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(841236..841722) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 841246 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 841249..841268 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(841253..841259) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 841282..841677 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 841282..841677 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(841708..841727) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(841722) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 841762..841768 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 841777 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 841782..841793 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(841792..841806) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(841806) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(841814..841818) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 841814..842236 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 841814..842236 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(842140..842240) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(842180) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 842214 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(842246) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 842286..842293 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 842307..842326 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 842315 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 842363..843025 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 842363..843025 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 843041..844582 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 843041..844582 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 844565 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 844666..844857 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 844666..844857 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 844888..844895 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 844910..844929 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 844921..845002 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 844921 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 845003..846355 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 845003..846355 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 846383..846961 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 846383..846961 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 846956..846963 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846978..846997 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846989 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 847004 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 847049..847139 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 847140..847964 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 847140..847964 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 847983..849473 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 847983..849473 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 848784..848790 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 848805..848824 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 848815 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 849474..849562 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 849519 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 849525..849625 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 849585 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 849614..851281 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 849614..851281 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 851043..851048 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 851063..851081 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 851072 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 851126..851132 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 851147 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 851148..851166 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 851249 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 851294..851367 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 851349..851356 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 851369 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 851370..851389 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 851413..853158 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 851413..853158 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 853147 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 853192..853261 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 853263..853282 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 853263 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 853307..854446 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 853307..854446 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 854443..855087 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 854443..855087 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 855084..855608 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 855084..855608 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 855573 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(855623..855865) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(855623..855865) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(855644) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(855901..855912) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(855912) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(855926..855933) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 856000..856006 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 856020..856031 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 856030 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 856066..856389 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 856066..856389 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 856390..858256 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(856431..857897) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(856431..857897) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(856443) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(856530) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(857937..857955) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(857949) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(857969..857976) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(858050..858490) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(858050..858490) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(858080) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 858478..858484 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 858498..858509 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 858500..858610 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 858500 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(858512..858531) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(858528) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(858543..858549) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 858569 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(858597..860255) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(858597..860255) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(858602) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(860146..860164) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(860166) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(860178..860184) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 860227..860232 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860248..860266 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860261 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 860286..861692 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 860286..861692 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 861672 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(861722..863107) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(861722..863107) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(861748) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(863134) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(863136..864667) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(863144..863155) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 863263..863270 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 863283..863302 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 863289..863576 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 863289 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 863539..863542 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 863557..863576 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 863578 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 863637..864641 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 863637..864641 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 864503 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 864633 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(864667) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(864674..864689) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 864679 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(864701..864710) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(864712..865587) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(864712..865587) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 865640..865641 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(865653..865672) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 865658..865677 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(865659) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 865668 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(865687..865692) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 865696..866796 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 865696..866796 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 866807..866813 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866828..866846 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866833 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 866870..867739 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 866870..867739 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 867747 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 867824..867827 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 867839 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 867842..867861 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 867887..867906 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 867892..867988 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 867892 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 867989..869386 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 867989..869386 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 869366 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 869447..869451 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 869467..869486 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 869474 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 869504..870859 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 869504..870859 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 870840 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(870894..872303) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(870894..872303) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 872352..872355 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872370..872389 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872372 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(872374..872393) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(872386) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(872409..872413) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 872413..872841 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 872413..872841 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 872820 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(872872..873162) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(872872..873162) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(872896) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(873150..874226) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(873150..874226) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(874216..874707) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(874216..874707) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(874708..874810) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(874799..874818) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(874810) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(874832..874835) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 874848..874854 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 874865 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 874869..874887 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(874898) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 874904..875899 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 874904..875899 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 875878 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 875961..875964 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875979..875998 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875984 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 876034..876633 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 876034..876633 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 876648 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 876693..878647 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(876702..878036) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(876702..878036) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(876721) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(878097..878528) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(878097..878528) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(878540..878559) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(878550) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(878574..878580) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(878576..878676) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 878611..878618 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(878616) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 878632..878651 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 878649 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 878685..879866 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 878685..879866 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 879851 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 879896..880034 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 880030..880049 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 880036..880192 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 880036 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 880193..881578 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 880193..881578 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 881468 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 881554 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(881592..881948) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(881592..881948) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(881945..882340) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(881945..882340) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(882327..883058) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(882327..883058) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(883083..883102) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(883104) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 883151..883159 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 883168 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 883173..883188 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 883182..883255 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 883242..883243 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 883257 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 883259..883278 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 883292..883399 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 883292..883399 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 883400..883453 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 883424 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 883504..883523 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 883510 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 883548..884663 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 883548..884663 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 884643 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 884700..884719 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 884700 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 884733..885476 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 884733..885476 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 885448 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(885500..886348) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(885500..886348) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(885524) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 886344..886349 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(886349..886448) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 886365..886383 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886367 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 886372..886567 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(886437..886456) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886451) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(886471..886474) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 886566..886585 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 886569..886632 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 886569 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 886633..887481 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 886633..887481 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 887472 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(887524..888885) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(887524..888885) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(887548) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(888886..888956) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(888929..888948) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(888956) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(889012..889512) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(889012..889512) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(889044) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(889534..889552) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(889554) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(889567..889573) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 889591..889598 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 889606..889675 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 889607 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 889613..889632 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 889676..889837 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 889676..889837 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 889767 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 889838..889956 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 889957..891714 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 889957..891714 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 891711..893732 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 891711..893732 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 893720 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(893781..894401) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(893781..894401) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(893796) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 894386..894486 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(894415..894434) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(894430) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(894440..894565) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(894440..894565) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 894446 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(894449..894452) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(894579..894598) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(894588) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(894612..894621) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 894644 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(894670..894873) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(894670..894873) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(894675) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(894874..894984) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 894914..895014 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 894974 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(894990) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(894994..895005) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(895020..895026) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(895082..895300) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(895082..895300) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(895116) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(895341..895360) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(895358) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(895374..895381) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(895450..896811) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(895450..896811) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(895468) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(895512) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(896801..897892) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(896801..897892) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(897216..897230) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897228) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897244..897252) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(897893..897998) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(897982..898000) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898002) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(898016..898021) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 898064..898071 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 898086..898105 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 898097 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 898159..899292 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 898159..899292 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 899293..899384 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 899385..899738 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 899385..899738 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 899726 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(899782..900855) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(899782..900855) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(899889) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(900877..900896) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(900889) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(900910..900917) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 900992..900999 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 901012 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 901014..901033 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 901023..901176 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 901133 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 901178..901261 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 901218 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 901274..901279 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901295..901313 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901304 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 901341..902207 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 901341..902207 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 902189 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 902252..902255 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 902270..902289 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902278 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 902319..903824 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 902319..903824 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 903794 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(903842..905059) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(903842..905059) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(903848) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(905066..905563) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(905066..905563) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(905627..905965) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(905627..905965) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(905977..905996) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(906001) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(906010..906017) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 906037..906044 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 906059..906078 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 906069 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 906130..906897 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 906130..906897 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 906898 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(906918..907103) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(906918..907103) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(907139..907157) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(907150) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(907168..907176) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 907177..907180 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 907195..907214 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 907205 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 907230..908126 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 907230..908126 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 908119..909378 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 908119..909378 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 909362 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 909426..909433 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909445..909464 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 909450 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 909485..910711 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 909485..910711 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(910186) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 910716..913607 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 910716..913607 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 911997..912002 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 912018..912036 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 912024 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 913615..913620 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913635..913654 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913650 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 913681..914625 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 913681..914625 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 914603 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 914684..914689 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 914705..914723 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 914708 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 914750..914962 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 914750..914962 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 914955 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(914993) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(915003..915881) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(915003..915881) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(915191) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915919..915938) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915943) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915952..915959) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 915979..915988 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 916000 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 916001..916020 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(916037..916051) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916038) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 916041..916127 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 916041..916127 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(916060..916064) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 916128..916379 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 916252..916338 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 916252..916338 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 916336 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(916348..916610) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 916381..916864 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(916391) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(916603..916622) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916610) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(916612..916680) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(916636..916641) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(916681..917199) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(916681..917199) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 916986..916994 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 917006..917024 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 917019 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(917230..917249) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917248) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917265..917271) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 917348..917351 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 917366..917385 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 917371 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 917407..917748 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 917407..917748 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(917602..917744) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(917645) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(917745..918356) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(917745..918356) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 917749..918514 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(917821) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 918352..918356 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 918364..918377 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 918376 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(918381..918400) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(918404) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(918415..918418) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 918471 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(918534..918890) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(918534..918890) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(918538) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 918967..918972 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(918973..918992) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(918987) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 918988..919006 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 918988 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(918989..919252) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 919020..919211 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 919020..919211 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 919212..920647 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(919285..919803) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(919285..919803) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(919297) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(919804..919891) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(919883..919902) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(919891) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(919916..919923) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(919928..921007) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(919928..921007) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(921046..921065) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(921057) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(921059..921140) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(921154..921591) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(921154..921591) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(921185) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(921624..921643) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921638) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 921641 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(921657..921664) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(921663..921959) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(921706) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(921957..921968) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921963) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921983..921989) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 922019..922026 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922040..922059 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922049 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 922079..922822 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 922079..922822 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 922815..924041 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 922815..924041 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(923374..923392) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(923389) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(923408..923413) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 924061..924771 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 924061..924771 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 924735 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(924789..925979) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(924789..925979) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(924799) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(924864) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(926003..926022) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(926024) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(926036..926041) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(926052..927443) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(926052..927443) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(927454..927473) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(927459) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(927486..927495) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(927509..927823) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(927509..927823) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(927868..928368) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(927868..928368) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(927895) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(928381..928400) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 928383..928387 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(928402) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 928403..928422 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 928404 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(928417..928418) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 928435..928441 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 928456..928467 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 928461 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 928490..930634 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 928490..930634 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(928534..928545) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(928537) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(928559..928565) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 930671..930677 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930691..930710 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 930701 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 930756..931817 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 930756..931817 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 931889..932821 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 931889..932821 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 932836..934248 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 932836..934248 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 932839 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 934225 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 934309..934316 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 934330..934349 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 934335 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 934394..934969 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 934394..934969 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 934713..934716 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 934731 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 934733..934752 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 934970..935039 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 935040..937367 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 935040..937367 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 937349 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(937409..938386) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(937409..938386) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(937422) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(938400..938419) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938418) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938433..938439) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 938445..938453 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938464..938482 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938471 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 938513..939289 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 938513..939289 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(939005..939626) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 939290..939661 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(939604..939623) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(939625) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(939637..939646) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 939639..939646 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939661..939680 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939663 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 939702..940742 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 939702..940742 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 940755..941162 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 940755..941162 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 941133 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(941199..942488) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(941199..942488) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(941229) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(942489..942589) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(942588..942607) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(942589) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(942591..942727) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(942622..942628) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(942759..942899) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(942759..942899) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(942772) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(942918..942937) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(942937) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(942950..942957) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 942981..942987 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943001..943020 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943004 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 943051..943785 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 943051..943785 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 943798..944793 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 943798..944793 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 944858..945502 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 944858..945502 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 945490 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 945530..945533 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 945548..945567 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 945555 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 945619..947160 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 945619..947160 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 947140 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(947199..947594) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(947199..947594) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(947216) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(947614..947625) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(947618) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(947640..947646) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 947679..947682 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 947690 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947697..947716 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 947743..949023 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 947743..949023 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(948170..948189) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(948184) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(948205..948210) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 949010 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(949060) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(949062..950207) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(949062..950207) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(950208..950274) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(950263..950282) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(950280) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(950298..950302) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 950587..950594 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 950609..950628 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 950611 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 950642..951091 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 950642..951091 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 951107..951114 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951129..951148 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951136 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 951163..952155 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 951163..952155 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 952156 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 952201..952311 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 952289..952296 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 952312..952331 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 952313 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 952372..953343 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 952372..953343 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 953322 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(953375..953956) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(953375..953956) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(953398) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(953980..953999) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953992) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954015..954018) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(954027..955121) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(954027..955121) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(955118..956557) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(955118..956557) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(956564..957124) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(956564..957124) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(956574..956593) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(956588) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(957149..957168) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(957163) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(957183..957190) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(957259..958557) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(957259..958557) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(957270) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(958611..958629) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958614) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958643..958649) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(958696..960225) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(958696..960225) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(960252..960270) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(960262) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 960281..960286 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(960285..960290) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 960298 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 960302..960320 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 960337..961194 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 960337..961194 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 961176 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(961222..961455) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(961222..961455) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(961255) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(961472..961491) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 961475..961476 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 961475 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 961479..961494 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(961494) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(961496..962351) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(961506..961513) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 961678..961685 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 961697..961716 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 961703 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 961748..962326 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 961748..962326 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 962327..962472 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(962373..963272) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(962373..963272) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(962396) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 962459..962462 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962474 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962480..962484 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 962518 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 962563..963429 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(963299..963317) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963316) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963332..963338) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 963406..963413 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963428..963447 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 963431 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 963489..963758 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 963489..963758 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 963750 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(963798) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(963801..965270) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(963801..965270) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(965267..965467) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(965267..965467) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(965468..965586) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(965569..965588) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(965586) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(965601..965608) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(965674) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(965675..966037) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(965675..966037) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 965875..965880 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965896..965914 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965897 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 965906..966145 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(966067..966086) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966085) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(966101..966108) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 966127..966134 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 966147 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 966148..966167 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 966189..966812 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 966189..966812 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 966814..967320 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 966814..967320 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 967313 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 967371..967378 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 967392..967411 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 967401..967500 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 967401 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 967501..969000 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 967501..969000 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 969008..969015 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 969027 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 969029..969048 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 969077..969604 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 969077..969604 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 969566 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(969618..>969638) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(969638,969654) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 969639..969653 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <969654..969940 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<969654..969775) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(969660) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(969776..970930) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(969776..970930) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(970931..971002) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(970985..971004) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(971001) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(971018..971023) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(971037..972242) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(971037..972242) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 972263..972282 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 972268 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 972356..974083 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 972356..974083 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 973669..973676 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 973691..973710 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 973698 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(974113..974439) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(974113..974439) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(974557..974994) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(974557..974994) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(974566) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(975025..975044) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(975045) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(975057..975066) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 975114..975121 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 975135..975154 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 975147 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 975178..978678 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 975178..978678 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 978665..982363 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 978665..982363 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 982364..982434 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 982435..983610 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 982435..983610 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 983607..986999 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 983607..986999 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 986254..986260 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986275..986286 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986282 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(986351..987324) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 987013..987315 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 987013..987315 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 987295 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(987369) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 987373..987374 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 987393 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(987432..988019) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(987432..988019) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(988034..988053) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(988053) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(988069..988071) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 988074..988080 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988092 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988095..988113 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 988098..988164 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 988165..990009 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 988165..990009 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 990010..990077 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 990034 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(990139..990618) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(990139..990618) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(990638) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(990642..990660) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(990671..990679) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 990810..990814 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 990827 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 990829..990848 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 990850..991674 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 990850..991674 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 991062..991068 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991083..991101 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991090 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 991684..993134 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(991704..993071) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(991704..993071) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 993103..993110 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993124..993143 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993136 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 993195..994058 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 993195..994058 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 994076..995089 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 994076..995089 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 995072 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 995141..995148 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995163..995182 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 995182..995297 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 995182 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 995298..996326 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 995298..996326 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 996348 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(996377..996886) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(996377..996886) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(996396) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(996899..996917) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996915) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(996929..996937) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(996936..997598) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(996936..997598) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 997617..997623 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997637..997656 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997646 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 997665..999119 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 997665..999119 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(998974..999126) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(999009) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(999127..999765) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(999127..999765) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(999766..999900) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 999814..999819 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 999835..999853 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 999836 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 999846..999970 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(999886..999905) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999900) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999920..999927) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 999971..1000777 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 999971..1000777 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1000770 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1000805..1001404) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1000805..1001404) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1000824) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1001401..1002570) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1001401..1002570) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1002571..1002682) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1002683..1003393) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1002683..1003393) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1003437..1003456) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1003459) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1003469..1003478) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003508..1003517 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003531..1003550 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003542 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1003578..1004264 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1003578..1004264 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1004261..1005019 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1004261..1005019 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1005016 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1005064..1005693) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1005064..1005693) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1005727..1005745) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005744) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005760..1005765) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1005789..1006904) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1005789..1006904) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1005818) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1006913..1008181) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1006913..1008181) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1008207..1008218) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1008216) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008232..1008238) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1008293..1009141) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1008293..1009141) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1008304) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1009146..1009595) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1009146..1009595) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1009616..1009635) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1009630) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1009651..1009652) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1009685..1011523) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1009685..1011523) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1009712) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1011605) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1011613..1011730) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1011613..1011730) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1011782..1011801) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1011796) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1011816..1011823) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1011837..1012328) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1011837..1012328) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1012346..1012349 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1012352..1012371) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1012364..1012383 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1012365 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1012370) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1012386..1012393) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1012427..1013323 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1012427..1013323 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1013310 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1013386) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 1013398..1013399 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_016" S_feature <1013399..1013452 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" promotor_-10 complement(<1013399..1013413) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1013417) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1013431..1013436 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013451..1013469 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1013454 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1013491..1014333 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1013491..1014333 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1013986..1013994 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1014005..1014023 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1014005 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1014334..1014447 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1014448..1014807 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1014448..1014807 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1014796 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1014838..1015035) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1014838..1015035) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1014851) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1015036..1015232) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1015232) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1015234..1015245) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1015260..1015266) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1015292..1016104) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1015292..1016104) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1016142..1016161) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1016162..1016169 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1016162) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1016175..1016182) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1016181..1016200 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1016183 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1016225..1016992 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1016225..1016992 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1017001..1017007 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1017021 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1017022..1017041 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1017056..1017364 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1017056..1017364 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1017349 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1017394..1017659 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1017660..1019090 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1017660..1019090 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1019135..1019629 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1019135..1019629 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1019593 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1019767..1019774 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1019773 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1019788..1019807 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1019836..1020873 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1019836..1020873 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1020893..1022113 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1020893..1022113 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1022128..1022904 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1022128..1022904 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1022901..1024058 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1022901..1024058 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1024129..1025184 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1024129..1025184 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1024739,1024740) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1025018..1025037) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1025028) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1025177..1028269 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1025177..1028269 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1028257..1029216 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1028257..1029216 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1029179 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1029219..1029493) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1029244..1029250 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1029252) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1029265..1029276 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1029286 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1029302..1029481 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1029302..1029481 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1029491 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1029527..1029712) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1029527..1029712) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1029538) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1029741..1029760) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1029758) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1029771..1029778) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1029813..1029819 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1029831..1029850 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1029836 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1029893..1029902 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1029902 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1029915..1029934 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1029961..1030695 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1029961..1030695 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1030454..1031056) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1030676..1030681 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1030694 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1030694 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1030697..1030715 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1030777..1031334 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1030777..1031334 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1031036..1031055) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1031056) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1031070..1031074) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1031341..1031348 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1031363..1031382 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1031375 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1031425..1032378 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1031425..1032378 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1032042..1032046 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1032062..1032081 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1032075 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1032393..1032584 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1032393..1032584 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1032563 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1032608..1032948 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1032614..1032853) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1032614..1032853) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1032630) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1032866..1032885) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032887) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032899..1032908) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1032914..1032921 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1032936..1032955 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1032950 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1033018..1033956 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1033018..1033956 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1033095..1033104 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1033113 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1033116..1033131 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1033979..1035220 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1033979..1035220 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1034193..1034211) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1034201) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1034227..1034232) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1035071 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1035204 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1035245..1035254 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1035267..1035286 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1035269 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1035281..1035289 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1035296..1036081 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1035296..1036081 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1035301..1035319 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035313 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1036082..1036166 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1036098..1036116) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1036115) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1036131..1036136) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1036134..1036141 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1036156..1036175 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1036168..1036272 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1036168 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1036273..1037259 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1036273..1037259 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1037256..1038245 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1037256..1038245 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1038251..1038257 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1038256..1038332 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1038256 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1038333..1038824 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1038333..1038824 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1038797..1039963 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1038797..1039963 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1039954 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1040039..1040989 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1040039..1040989 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1041006..1041917 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1041006..1041917 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1041931 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1041976..1042083 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1042056..1042061 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1042077..1042095 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1042085 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1042122..1042874 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1042122..1042874 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1042854 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1042909..1043901) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1042909..1043901) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1042930) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1043960..1044174) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1043960..1044174) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1044008) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1044193..1044212) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1044206) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1044461..1044468 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1044482..1044644 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1044483..1044502 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044483 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1044645..1046282 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1044645..1046282 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1046176 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1046283..1046389 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1046390..1047325 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1046390..1047325 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1046433..1046452) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1046450) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1046468..1046474) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1047329..1048246 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1047329..1048246 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1048251..1049327 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1048251..1049327 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1049329..1050246 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1049329..1050246 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1050216 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1050296..1050299 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1050312 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1050314..1050333 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1050353..1051570 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1050353..1051570 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1051623..1051632 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1051645..1051660 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1051654..1051733 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1051654 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1051734..1052312 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1051734..1052312 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1052313..1052427 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1052364..1052383) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052368) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052397..1052404) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1052430..1052443 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1052430 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1052493..1052888 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1052493..1052888 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1052724..1052824) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1052764) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1052886 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1052931..1053720 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1052931..1053587) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1052931..1053587) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1053617..1053635) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053632) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1053650..1053655) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1053693..1053700 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053714..1053733 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1053722..1053863 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1053722 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1053757..1053897 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1053757..1053897 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1053864..1054520 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1053864..1054520 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1054510 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1054515..1054637) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1054515..1054637) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1054555..1054644 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1054623..1054631 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054642..1054660 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1054646..1054710 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1054646 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1054711..1055832 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1054711..1055832 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1055486..1055492 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1055504 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1055507..1055525 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1055718..1055726 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1055738..1055756 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1055745 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1055826..1055832 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055847..1055858 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055856 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1055879..1057891 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1055879..1057891 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1055954..1055961 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1055976..1055995 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1055988 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1057838 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1057892..1058193 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1057929..1058096) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1057929..1058096) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1057942) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1058116..1058134) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058132) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1058150..1058155) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1058186..1058193 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1058195..1058320 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1058195 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1058201..1058339 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1058201..1058339 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1058208..1058227 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1058277 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1058410..1059309) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1058410..1059309) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1058441) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1058645..1058650 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1058657 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1058666..1058684 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1058673..1060574 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1059306..1059704) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1059306..1059704) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1059705..1059884) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1059876..1059895) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1059884) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1059907..1059914) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1059959..1060504) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1059959..1060504) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1059983) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1060505..1060707) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1060708..1061280) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1060708..1061280) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1060853..1060871) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1060862) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1060884..1060891) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1061309..1061328) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1061326) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1061342..1061345 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1061343..1061350) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1061358 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1061361..1061380 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1061405..1061773 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1061405..1061773 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1061802..1062437 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1061802..1062437 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1062456..1063256 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1062456..1063256 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1063319..1064170 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1063319..1064170 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1064129 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1064183..1064917) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1064183..1064917) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1064205) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1065039..1065043 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1065060..1065079 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1065074 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1065075..1065151 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1065152..1066996 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1065152..1066996 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1065479..1065498) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1065503) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1066998..1067005 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1067019..1067038 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1067025 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1067058..1067166 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1067058..1067166 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1067161 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1067245..1067955 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1067245..1067955 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1067930..1068547 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1067930..1068547 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1068531..1069640 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1068531..1069640 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1069640..1069840 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1069640..1069840 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1069837..1070607 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1069837..1070607 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1070604..1071614 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1070604..1071614 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1071633..1072448 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1071633..1072448 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1072422 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1072495..1072501 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072514..1072533 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072524 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1072584..1073360 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1072584..1073360 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1073349 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1073364..1073365 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1073365..1074425 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1073369..1075648) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1073369..1075648) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1073387) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1075523..1075697) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1075576..1075584 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075595..1075613 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1075599..1075734 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1075599 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1075685..1075704) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1075696) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1075712..1075718 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1075720..1075724) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075733..1075751 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1075736 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1075765..1076019 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1075765..1076019 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1075995 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1076085) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1076092..1076514) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1076092..1076514) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1076518..1077033) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1076518..1077033) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1077070..1077792) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1077070..1077792) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1077831..1077850) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1077852) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1077901..1077908 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077923..1077942 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077927 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1077960..1078080 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1077960..1078080 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1078085 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1078148..1079269 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1078148..1079269 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1079262..1080434 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1079262..1080434 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1080417 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1080451..1080469 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1080461 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1080462..1081991 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1080467..1081012) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1080467..1081012) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1080488) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1081082..1082272) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1081082..1082272) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1082298..1082317) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1082302) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1082332..1082339) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1082366..1082373 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1082377 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1082387..1082406 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1082445..1082517 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1082445..1082517 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1082459..1082476) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1082473) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1082497..1082503) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1082507 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1082532..1083267) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1082552..1084200 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1082561) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1083269..1083357) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1083312) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1083358..1084587) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1083358..1084587) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1083480) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1084157 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1084588..1084673) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1084628..1084635 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1084650..1084669 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1084659..1084678) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1084663 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1084677) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1084691..1084697) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1084713..1085033 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1084713..1085033 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1085043 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1085088..1085185 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1085186..1085317 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1085186..1085317 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1085333..1085506 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1085333..1085506 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1085543..1086004 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1085543..1086004 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1085975..1085982 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1085997..1086016 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1086005..1086245 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1086005 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1086218..1086225 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1086239..1086257 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1086247 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1086270..1086773 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1086270..1086773 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1086785..1087069 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1086785..1087069 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1087039 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1087071) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1087082..1087085) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1087230..1087757 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1087230..1087757 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1087904..1087909 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1087922..1087941 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1087925 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1087931..1088248 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1087931..1088248 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1088249..1088484 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1088485..1089240 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1088485..1089240 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1089241..1089328 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1089285 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1089328..1089388) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1089359) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1089389..1089736) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1089389..1089736) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1089768..1089786) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1089781) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1089783..1090239) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1089797..1089805) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1090199..1090217 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1090211 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1090217..1090236) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090239) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090250..1090257) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1090287..1092233 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1090287..1092233 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1092209 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1092263..1092264 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1092264..1092362 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1092337..1092343 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1092358..1092377 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1092364..1092432 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1092364 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1092433..1092915 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1092433..1092915 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1092895 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1092961..1093467) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1092961..1093467) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1092985) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1093492..1093511) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1093498) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1093500..1093685) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1093686..1094081) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1093686..1094081) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1094104..1094122) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1094117) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1094119..1094819) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1094137..1094142) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1094225..1094232 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1094246..1094265 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1094257 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1094310..1094789 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1094310..1094789 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1094788 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1094829..1095023) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1094829..1095023) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1094864) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1095037..1095052) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095053) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1095064..1095073) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1095189..1095518) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1095189..1095518) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1095555..1095574) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095568) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1095570..1096137) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1095589..1095594) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1095622..1095626 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1095642..1095661 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1095646..1096147 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1095646 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1096138..1097127) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1096138..1097127) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1097128..1097147) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1097131) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1097161..1097166) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1097250..1097498) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1097250..1097498) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1097260) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1097494..1097498 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1097507..1097521 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1097516 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1097523..1097542) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097532) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1097556..1097565) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1097613..1097620 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1097627..1097646) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1097634..1097653 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097636) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1097647 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1097648..1097751 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1097660..1097667) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1097752..1099155 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1097752..1099155 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1099144 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1099195..1099668) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1099195..1099668) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1099199) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1099690..1099708) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1099708) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1099723..1099728) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1099793..1099960) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1099793..1099960) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1099796) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1099972..1099990) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1099981) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1100003..1100010) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1100087..1100986 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1100087..1100986 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1100995..1101393) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1100995..1101393) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1101025) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1101422..1101441) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1101441) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1101456..1101463) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1101494..1102069) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1101494..1102069) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1101509) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1102088..1102106) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102103) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1102120..1102126) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1102144..1102150 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1102165..1102183 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1102166 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1102215..1105172 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1102215..1105172 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1105165..1105725 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1105165..1105725 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1105718 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1105763..1105881 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1105859..1105862 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1105878..1105897 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1105883 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1105922..1106563 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1105922..1106563 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1105931) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1106536 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1106642..1107268 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1106642..1107268 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1107270 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1107273) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1107299..1107577) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1107299..1107577) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1107317) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1107606..1107617) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1107619..1107625) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1107625) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1107627..1108043) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1107795 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1107796..1107815 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1107813..1107967 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1107968..1109158 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1107968..1109158 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1108041..1108060) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1108043) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1108074..1108083) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1109181..1110359 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1109181..1110359 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1110400..1110588) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1110400..1110588) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1110416) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1110614..1110633) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1110617) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1110647..1110653) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1110675..1110682 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1110697..1110716 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1110708 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1110723..1110742) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1110727) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1110757..1110764) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1110762..1111574 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1110762..1111574 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1111553 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1111620..1112372) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1111620..1112372) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1111629) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1112372..1113124) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1112372..1113124) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1113244..1114218) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1113244..1114218) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1113279) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1114239..1114258) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1114265) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1114267..1116773) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1114273..1114280) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1114301..1114307 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1114322..1114340 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1114325 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1114350..1114847 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1114350..1114847 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1114848..1114961 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1114941..1114945 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1114961..1114980 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1114963..1115235 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1114963 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1115236..1115658 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1115236..1115658 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1115698..1116876 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1115698..1116876 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1116707..1116807 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1116765..1116783) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1116767 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1116773) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1116795..1116803) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1116875 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1116984..1116991 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1117006..1117025 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1117031 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1117074..1118495 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1117074..1118495 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1118563..1119942 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1118563..1119942 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1119082..1119101) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1119087) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1119115..1119122) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1119967 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1119977..1119984 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1119979..1120046 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1120047..1121060 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1120047..1121060 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1121066..1122085 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1121066..1122085 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1122110..1123189 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1122110..1123189 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1123186..1124022 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1123186..1124022 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1124070..1125338 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1124070..1125338 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1125282..1125285 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1125301..1125305 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1125303 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1125371..1125390 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1125371 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1125426..1126427 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1125426..1126427 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1126109..1126209) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1126149) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1126403 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1126504..1127946 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1126504..1127946 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1127943..1129436 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1127943..1129436 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1129475..1130239) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1129475..1130239) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1129494) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1130007,1130009) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1130266,1130273) /created_by="User" /modified_by="User" /label="TF8A" N_region 1130267..1130272 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1130275..1130595 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1130275..1130595 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1130604 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1130613..1130816) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1130632..1130769) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1130632..1130769) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1130656) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1130855..1131025) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1130855..1131025) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1130861) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1131025..1131771) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1131025..1131771) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1131606..1131625) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1131623) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1131641..1131648) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1131797..1131815) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1131810) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1131831..1131836) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1131881..1132882) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1131881..1132882) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1131910) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132895..1133512) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1132895..1133512) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1133548..1133567) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1133550) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1133552..1133649) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1133583..1133587) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1133629..1133648) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1133649) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1133663..1133670) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1133694..1133713) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1133706) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1133788..1135104) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1133788..1135104) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1133803) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1135151..1135170) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1135167) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1135185..1135188) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1135387..1135394 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1135409..1135428 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1135421..1135492 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1135421 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1135493..1136443 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1135493..1136443 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1136431 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1136544..1136690 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1136544..1136690 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1136698..1138848 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1136698..1138848 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1137587..1137687 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1137647 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1137735 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1138860..1139831 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1138860..1139831 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1139188..1139829) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1139874) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1139899..1140265) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1139942) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1140245..1140260) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1140265) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140272..1140281) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1140349..1141698) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1140349..1141698) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1140363) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1141738..1141745 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1141750..1141769) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1141758 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1141760..1141779 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1141768) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1141770..1141852) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1141780..1141787) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1141809..1141815 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1141830..1141849 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1141833 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1141835..1141854) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1141852) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1141867..1142685 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1141867..1142685 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1141870..1141873) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1142663 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1142742..1142749 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1142764..1142783 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1142768 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1142814..1143638 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1142814..1143638 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1143655..1144581 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1143655..1144581 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1144587..1145549 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1144587..1145549 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1145281..1145286 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1145302..1145320 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1145303 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1145554..1146561 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1145554..1146561 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1146564..1148213 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1146564..1148213 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1148207 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1148301..1149260 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1148301..1149260 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1149257..1150357 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1149257..1150357 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1150354..1151244 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1150354..1151244 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1151257..1152246 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1151257..1152246 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1151540..1152267) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1152236 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1152281..1153449 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1152289..1153338) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1152289..1153338) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1152312) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1153365..1153384) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153376) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153399..1153406) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1153428..1154288) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1153428..1154288) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1154313..1154331) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1154330) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1154347..1154353) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1154362..1154369 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154383..1154402 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154390 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1154448..1154966 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1154448..1154966 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1154957 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1155031..1155037 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1155049..1155155 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1155049 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1155051..1155062 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1155130..1155133 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1155149..1155168 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1155157 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1155205..1156404 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1155205..1156404 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1156393 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1156438..1156809 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1156481..1156705) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1156481..1156705) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1156785..1156791 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1156805..1156816 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1156811 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1156850..1157581 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1156850..1157581 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1157559 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1157620..1157628 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1157639..1157657 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1157647 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1157673..1158200 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1157673..1158200 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1158190..1158708 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1158190..1158708 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1158702..1158709 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1158723..1158742 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1158726 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1158741..1158852 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1158741..1158852 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1158815 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1158930..1159268 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1158930..1159268 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1159268..1159585 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1159268..1159585 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1159585..1159588 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1159604..1159623 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1159616 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1159656..1160558 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1159656..1160558 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1160549 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1160605..1160611 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1160617 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1160625..1160644 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1160646..1160856 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1160646..1160856 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1160814 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1160909..1162006 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1160909..1162006 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1161096..1161098 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161100..1161104 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1161100 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1162018..1163265 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1162018..1163265 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1163256 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1163327..1163334 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1163349..1163368 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1163358 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1163391..1163816 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1163391..1163816 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1163805 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1163847..1164290) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1163847..1164290) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1163881) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1164317..1164336) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1164323) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1164351..1164354) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1164372..1164378 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1164392..1164410 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1164398 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1164433..1164843 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1164433..1164843 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1164821 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1164870..1165040 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1164870..1165040 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1165041..1165718 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1165090..1165560) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1165090..1165560) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1165114) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1165582..1165601) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1165598) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1165600..1165707) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1165617..1165620) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1165676 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1165733..1168021) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1165733..1168021) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1165752) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1168022..1168084) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1168044..1168144) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1168084) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1168149..1168304) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1168149..1168304) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1168150) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1168337..1168356) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168349) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1168351..1168436) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1168372..1168379) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1168437..1169396) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1168437..1169396) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1169397..1169448) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1169441..1169460) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1169453) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1169474..1169480) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1169565..1169568 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1169581 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1169584..1169603 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1169619..1170452 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1169619..1170452 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1170428 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1170483..1171247) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1170483..1171247) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1170504) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1171222..1172865) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1171222..1172865) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1172852..1173451) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1172852..1173451) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1173453..1174055) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1173453..1174055) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1174133) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1174152..1174264) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1174152..1174264) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1174265..1174268 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1174279..1174298) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1174284..1174303 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174295 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1174300) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1174313..1174320) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1174366..1175052 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1174366..1175052 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1175056..1176420 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1175056..1176420 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1176417..1177097 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1176417..1177097 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1177126..1177131 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1177147..1177165 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1177150 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1177189..1177701 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1177189..1177701 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1177687 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1177732..1177738 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1177752..1177763 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1177753 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1177784..1177921 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1177784..1177921 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1177894 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1177980..1177987 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178001..1178020 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178003..1178322 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1178003 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1178035..1178188 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1178035..1178188 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1178300..1178309 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178322..1178341 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178324..1178425 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1178324 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1178426..1179781 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1178426..1179781 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1179772 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1179824..1180156) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1179824..1180156) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1180172..1180191) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1180182) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1180184..1180572) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1180207..1180212) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1180244..1180344 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1180304 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1180351..1180506 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1180351..1180506 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1180515..1180522 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180529..1180546 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180546 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1180557..1180576) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1180572) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1180590..1180596) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1180594..1180776 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1180594..1180776 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1180744 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1180801..1180809 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180820..1180838 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1180826..1180908 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1180826 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1180909..1181373 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1180909..1181373 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1181358 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1181388..1182509) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1181388..1182509) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1181797..1181805 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1181819..1181838 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1181822..1182600 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1181822 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1182538..1182549) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1182558) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1182564..1182570) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1182601..1183152 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1182601..1183152 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1183120 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1183180..1183992) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1183180..1183992) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1183952..1183971) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1183966) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1183985..1183990) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1184093..1184099 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1184110..1184184 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1184110 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1184113..1184124 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1184185..1185879 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1184185..1185879 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1185892..1186905 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1185892..1186905 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1186890 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1186931..1188766) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1186931..1188766) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1186980) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188770..1189705) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1188770..1189705) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1189676..1189687) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189686) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189702..1189708) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1189742..1192144) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1189742..1192144) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1189774) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1191992..1192194) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1192183..1192201) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1192194) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1192215..1192222) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1192261..1192268 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1192282..1192301 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1192294 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1192325..1192990 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1192325..1192990 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1192859..1192878) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1192876) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1192892..1192901) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1192985..1192992 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1193007..1193026 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1193020 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1193046..1193179 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1193046..1193179 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1193067..1194041 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1193067..1194041 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1193130 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1194029 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1194151..1194159 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1194173..1194181 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1194183 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1194186..1194272 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1194245..1194252 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1194266..1194285 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1194274 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1194305..1195060 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1194305..1195060 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1195057..1196202 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1195057..1196202 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1196203..1197362 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1196213..1196407) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1196213..1196407) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1196220) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1196450..1196461) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196460) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1196476..1196482) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1196538..1197239) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1196538..1197239) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1196572) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1197240..1197320) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1197312..1197331) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197320) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1197336..1197343 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1197345..1197352) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197357..1197376 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197364 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1197410..1198306 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1197410..1198306 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1198300 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1198411..1198415 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198431..1198450 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198435 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1198480..1199829 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1198480..1199829 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1199817 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1199878..1199884 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199898..1199909 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1199906..1199973 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1199906 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1199974..1200129 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1199974..1200129 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1200132..1200308 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1200132..1200308 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1200198..1200298 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1200258 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1200304 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1200351..1201373) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1200351..1201373) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1200374) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1201418..1201437) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1201434) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1201449..1201455) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1201562..1201570 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1201578 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1201581..1201599 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1201626..1203842 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1201626..1203842 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1203617..1204557) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1203695..1203702 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1203717..1203736 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1203719 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1203839..1204336 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1203839..1204336 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1204337..1204576 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1204426..1204551 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1204426..1204551 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1204544 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1204585..1205646) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1204585..1205646) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1204602) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1205654..1206847) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1205654..1206847) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1205714 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1206934) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1206940..1207096) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1206940..1207096) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1207131..1207150) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1207132) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1207166..1207173) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1207176..1207179 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1207180..1207959) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1207180..1207959) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1207195..1207214 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207204 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1207652..1207659 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1207672..1207691 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1207687 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1207694..1208011 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1207981..1207988 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1207989..1208008) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1208003..1208022 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1208003) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1208013 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1208024..1208031) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1208054..1209250 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1208054..1209250 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1209232..1209239 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1209254..1209273 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1209273 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1209289..1209389 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1209289..1209389 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1209388 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1209474..1210691 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1209474..1210691 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1210688..1211395 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1210688..1211395 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1211353..1211982 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1211353..1211982 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1211997..1212533 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1211997..1212533 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1212380..1212573) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1212533 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1212574..1212894) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1212574..1212894) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1212632) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1212895..1212984) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1212920..1212926 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1212941..1212959 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1212951 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1212952..1213036 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1212966..1212985) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212983) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1213000..1213003) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1213010..1213017 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213032..1213051 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1213038..1213096 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1213038 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1213094) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1213097..1213354 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1213097..1213354 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1213348 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1213440..1213871 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1213440..1213871 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" downshifts complement(1213911) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" SCAR join(1213946,1214056) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_027" N_region 1213947..1214055 /modified_by="User" /label="IIG_Bs27_027" CDS complement(1214066..1216165) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1214066..1216165) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1214088) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1216166..1216416) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1216376..1216476) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1216416) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1216452..1216457 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1216467 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1216473..1216491 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1216530..1217573 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1216530..1217573 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1217574..1217665 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1217642..1217646 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217663..1217682 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217667 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1217712..1217756 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1217712..1217756 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1217733 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1217778..1217885 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1217886..1218545 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1217886..1218545 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1218538..1218987 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1218538..1218987 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1218980..1219711 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1218980..1219711 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1219729..1220226 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1219729..1220226 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1220227..1220503 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1220461 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1220471) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1220540..1220784) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1220581) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1220785..1221141) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1220785..1221141) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1221172..1221191) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1221189) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1221226..1221244 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1221231 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1221310..1222056 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1221310..1222056 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1222111 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1222459..1222467 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1222481..1222500 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1222485 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1222537..1223736 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1222537..1223736 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1222619..1222625 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1222640..1222658 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1222646 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1223705..1223707 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1223727..1223745 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1223739 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1223752..1223979 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1223752..1223979 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1223829..1223848) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1223837) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1223980..1224075 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1224076..1224774 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1224076..1224774 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1224727..1225553) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1224755..1225006 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1224755..1225006 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1225256..1225271 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1225279..1225490 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1225279 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1225455 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1225542..1225561) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225564) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1225577..1225584) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225629..1225636 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1225651..1225670 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1225653 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1225689..1225979 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1225689..1225979 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1226016..1226099) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1226059) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1226100..1226285) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1226100..1226285) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1226318..1226337) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1226329) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1226331..1226675) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1226351..1226358) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1226384..1226389 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1226405..1226424 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1226412 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1226451..1226645 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1226451..1226645 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1226621 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1226666..1226684) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1226682) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1226701..1226706) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1226944..1227570 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1226944..1227570 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1227501 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1227627..1227632 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1227639 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1227648..1227666 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1227688..1229025 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1227688..1229025 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1229076..1229573 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1229076..1229573 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1229422..1229428 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1229437 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1229443..1229461 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1229547 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1229668..1229674 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1229685..1229704 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1229697 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1229701..1229808 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1229809..1231722 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1229809..1231722 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1229958..1229977) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229975) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229990..1229999) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1230126..1230145) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230151) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230159..1230165) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1231703 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1231779) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1231990..1232009) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1231999) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232023..1232030) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1232074..1232093 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1232084 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1232129..1233220 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1232129..1233220 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1232869 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1233199 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1233233..1233451) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1233244..1233501 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1233438..1233457) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1233451) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1233473..1233480) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1233502..1234467 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1233502..1234467 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1234485..1234492 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1234507..1234526 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1234519 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1234530..1235396 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1234530..1235396 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1235251..1235255 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235272..1235291 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235280 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1235398 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1235443..1235594 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1235443..1235594 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1235443..1235594 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1235572..1235578 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235592..1235603 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235596 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1235625..1237724 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1235625..1237724 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1237742..1237746 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1237762..1237781 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1237773 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1237822..1238088 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1237822..1238088 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1238088..1239800 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1238088..1239800 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1239787 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1239840..1239846 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1239861..1239872 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1239864 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1239891..1240130 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1239891..1240130 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1239911..1241250) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1240208..1241236 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1240208..1241236 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1241206 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1241251..1241931) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1241251..1241931) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1241941..1241960) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1241964) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1241975..1241982) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1242016..1242023 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1242037..1242055 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1242043 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1242066..1244033 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1242066..1244033 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1242506..1242521) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1242518) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1244004 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1244077..1244079 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244095..1244114 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1244105 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1244147) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1244171..1245037 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1244171..1245037 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1245017 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1245076..1245849) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1245076..1245849) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1245093) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1245881..1245900) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1245891) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1246124..1246143 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1246137 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1246139..1246242 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1246186..1248300 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1246186..1248300 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1247479..1247497) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1247491) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1247513..1247518) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1248281 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1248373..1248381 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248393..1248411 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248405 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1248464..1250284 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1248464..1250284 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1250295..1251476) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1250295..1251476) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1250329) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1251504..1251523) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1251520) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1251552..1251570) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1251564) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1251566..1251634) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1251585..1251590) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1251628..1251647) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1251634) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1251678..1251839) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1251678..1251839) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1251862..1251881) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1251875) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1251895..1251902) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1251976..1251983 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1251995 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1251996..1252014 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1252043..1252954 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1252043..1252954 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1252048) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1252497..1252505 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1252519..1252536 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1252522 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1252939 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1252998..1253462) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1252998..1253462) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1253016) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1253492..1253511) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253502) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1253526..1253533) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1253588..1254880) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1253588..1254880) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1253610) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1254904..1254923) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1254908) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1254939..1254943) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1254956..1255450) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1254956..1255450) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1255466..1255485) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1255482) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1255499..1255508) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1255507..1256367) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1255507..1256367) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1256388..1256407) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1256401) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1256438..1256445 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1256461..1256480 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1256474 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1256510..1257274 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1256510..1257274 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1257275..1257423 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1257404..1257422 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1257425..1257574 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1257425 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1257472) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1257575..1259305 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1257575..1259305 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1259371..1259889 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1259371..1259889 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1259887 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1259932..1259937 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259950..1259969 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259953 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1259985..1260533 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1259985..1260533 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1260534..1260685 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1260686..1261909 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1260686..1261909 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1261872..1261890) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261882) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1261888 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1261905..1261910) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1261958..1261965 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1261977..1262078 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1261977 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1261980..1261999 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1261995..1262078 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1261995..1262078 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1262035 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1262089..1262094 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1262109..1262393 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1262109 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1262111..1262129 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1262370..1262376 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1262390..1262401 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1262395..1262482 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1262395 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1262471..1262490 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1262484 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1262555..1262794 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1262555..1262794 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1262795..1262903 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1262904..1263422 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1262904..1263422 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1263459..1263466 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1263480..1263499 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1263494 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1263556..1263753 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1263556..1263753 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1263749 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1263794..1263890 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1263891..1264334 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1263891..1264334 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1264335..1264442 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1264410..1264415 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1264430..1264449 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1264444 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1264483..1265364 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1264483..1265364 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1265343 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1265399..1265406 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1265421..1265440 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1265426 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1265476..1265952 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1265476..1265952 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1265942..1266835 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1265942..1266835 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1266851..1267306 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1266851..1267306 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1267122..1267141) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1267135) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1267155..1267163) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1267300 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1267345..1267352 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1267366..1267385 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1267367 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1267411..1268121 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1267411..1268121 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1267420) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1267530..1267534) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1267530) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1268191..1269315 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1268191..1269315 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1269327..1269333 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1269347..1269358 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1269349 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1269353..1269367) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1269377..1269381) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1269377..1269622 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1269377..1269622 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1269378) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1269610 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1269655..1270605 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1269659..1270462) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1269659..1270462) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1269671) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1270513..1270532) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270522) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270546..1270553) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1270578..1270585 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1270600..1270619 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1270607..1270698 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1270607 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1270699..1271241 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1270699..1271241 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1271313..1271759 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1271313..1271759 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1271767 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1272152..1272159 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1272172 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1272174..1272193 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1272225..1272800 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1272225..1272800 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1272778 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1272841..1273806) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1272841..1273806) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1272854) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1273150..1273151 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1273169..1273188 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1273175..1273899 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1273175 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1273827..1273845) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1273848) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1273860..1273865) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1273886..1273892 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1273902 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1273906..1273925 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1273943..1274542 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1273943..1274542 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1274593..1275612 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1274593..1275612 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1275630..1276922 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1275630..1276922 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1276883..1277404 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1276883..1277404 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1277404..1277877 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1277404..1277877 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1277870..1278103 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1277870..1278103 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1278082 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1278148..1278153 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1278170..1278188 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1278178 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1278190..1278276 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1278266..1278269 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1278278 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1278284..1278303 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1278327..1280084 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1278327..1280084 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1280096..1281910 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1280096..1281910 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1280533..1280552) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1280543) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1280567..1280574) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1281961..1281970 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1281982..1281997 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1281986 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1282020..1282715 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1282020..1282715 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1282720..1283853 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1282720..1283853 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1283854..1284546 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1283854..1284546 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1284543..1285736 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1284543..1285736 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1285714 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1285785..1285791 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285805..1285816 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285813 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1285858..1285865 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1285880..1285899 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1285885..1285976 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1285885 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1285940..1285947 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285961..1285980 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285978 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1286016..1286771 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1286016..1286771 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1286164) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1286166..1286168) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1286768..1287679 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1286768..1287679 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1287694..1289601 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1287694..1289601 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1289586 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1289670..1289677 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289688..1289707 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289691 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1289746..1290327 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1289746..1290327 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1290312 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1290356 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1290361..1290630) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1290361..1290630) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1290366) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1290631..1290696) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1290677..1290696) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1290696) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1290749..1290756 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1290767..1290786 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1290771 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1290811..1292433 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1290811..1292433 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1292421 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1292490..1293401 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1292490..1293401 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1293406 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1293435..1294667) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1293435..1294667) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1293446) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1294685..1294704) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294709) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294719..1294724) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1294777..1294911) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1294777..1294911) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1294788) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1294933..1294951) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294944) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1294946..1295011) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1294967..1294972) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1295012..1296019) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1295012..1296019) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1296065) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1296066..1296074) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1296088..1296096) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1296206..1296215 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1296227 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1296228..1296243 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1296230..1296302 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1296303..1296581 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1296303..1296581 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1296579 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1296613..1298242) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1296624..1296728 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1296636) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1296710..1296717 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296729..1296748 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1296730 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1296771..1298057 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1296771..1298057 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1298073..1298906 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1298073..1298906 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1298239..1298257) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298254) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1298273..1298278) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1298969..1299634 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1298969..1299634 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1299618 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1299725..1299731 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1299746..1299765) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1299746..1299765 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1299758 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1299760) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1299789..1301522 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1299789..1301522 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1300917..1301521) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1301511 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1301556..1303223) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1301556..1303223) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1301566) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1303229..1303438) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1303229..1303438) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1303475..1303494) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1303497) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1303499..1303676) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1303509..1303512) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1303677) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1303679..1303690) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1303704..1303710) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1303749..1303756 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1303770..1303789 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1303786 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1303824..1304597 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1303824..1304597 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1304568 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1304633..1305187) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1304633..1305187) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1304644) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1305209..1305228) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1305219) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1305243..1305250) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1305272 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1305296) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1305297..1305455) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1305297..1305455) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1305362..1305505) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1305362..1305505) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1305451..1305455 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1305456..1305524) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1305465..1305479 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1305492 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1305508..1305527) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1305537) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1305540..1305549) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1305611..1305618 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1305632..1305651 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1305636 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1305669..1306340 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1305669..1306340 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1306008..1306017 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1306030..1306048 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1306042 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1306287 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1306515..1306520 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1306537..1306556 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1306538..1306763 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1306538 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1306542..1306561) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1306558) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1306662..1306670) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1306668) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1306684..1306692) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1306764..1307879 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1306764..1307879 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1307883..1308860 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1307883..1308860 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1308861..1308974 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1308895..1308914) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1308912) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1308929..1308932) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1308975..1310303 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1308975..1310303 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1309119..1309126 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1309141..1309160 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1309144 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1310308..1311720 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1310308..1311720 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1311717 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1311765..1312139) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1311765..1312139) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1311813) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1312170..1312189) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1312180) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1312343..1312348 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1312364..1312382 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1312374 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1312378..1312487 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1312410) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1312471..1312478 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1312489 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1312493..1312512 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1312508..1312718 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1312508..1312718 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1312558..1312677 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1312558..1312677 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1312564) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1312664 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1312709..>1314308 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1312717..1314189) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1312717..1314189) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1312735) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1314190..1314285) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1314268..1314287) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1314285) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1314292..1314295 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1314302..>1314308) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 1314308..1314309 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_019" CDS 1314506..1316446 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1314506..1316446 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1316436..1316705 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1316436..1316705 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1316671..1316675 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1316689..1316708 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1316702 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1316705..1317226 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1316705..1317226 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1317223..1317516 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1317223..1317516 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1317556..1318167) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1317556..1318167) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1317570) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1318199..1318218) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1318208) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1318233..1318236) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1318423) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1318440..1318628) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1318440..1318628) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1318494) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1318650..1318669) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1318667) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1318682..1318689) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1318695..1318714 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1318702 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1318741..1320579 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1318741..1320579 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1320636..1320953 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1320636..1320953 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1320927 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1321002) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1321009..1321218) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1321009..1321218) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1321232..1321251) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1321247) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1321301..1321930) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1321301..1321930) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1321332) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1321832..1321850) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1321838) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1321862..1321870) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1321965..1321976) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1321970) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1321982..1321987 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1321991..1321997) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322003..1322021 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1322003 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1322004..1322084 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1322085..1323413 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1322085..1323413 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1323269..1323416) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1323312) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1323414..1324004 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1323417..1323902) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1323417..1323902) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1323914..1323933) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323942) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1323948..1323955) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1324005..1324934 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1324005..1324934 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1324519..1324538 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1324528 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1324958..1324961 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1324976..1324995 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1324984 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1325032..1325313 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1325032..1325313 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1325302 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1325376..1325379 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1325392..1325518 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1325392 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1325397..1325403 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1325519..1326730 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1325519..1326730 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1326740..1326744 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1326759..1326778 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1326778 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1326805..1330251 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1326805..1330251 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1329817..1329835) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329837) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1329851..1329856) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1330231 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1330276 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1330308) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1330320 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1330654..1331574) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1330654..1331574) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1330660) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1331614..1331633) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1331629) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1331647..1331654) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1331709..1331716 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331730..1331749 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1331731..1331836 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1331731 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1331838..1331928 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1331838 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1331844..1331847 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331862..1331878 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1331929..1332846 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1331929..1332846 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1332875 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1332894 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1332895..1332900 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1332954..1332959 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1332974..1332992 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1332982..1333085 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1332982 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1333086..1334156 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1333086..1334156 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1334189..1336057 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1334189..1336057 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1336057..1336680 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1336057..1336680 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1336683..1337015 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1336683..1337015 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1337042..1337935 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1337042..1337935 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1337910 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1337967..1338329) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1337967..1338329) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1337986) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1338322..1338326 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338335..1338348 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1338353..1338372) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1338357..1338468 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1338357 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1338365) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1338387..1338394) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1338469..1338915 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1338469..1338915 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1338501..1338508 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338520..1338539 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338525 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1338924..1338931 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338945..1338964 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338956 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1338999..1340039 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1338999..1340039 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1339962..1339980) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1339967) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1339996..1340001) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1340019 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1340203..1340212 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1340226..1340245 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1340240 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1340271..1340669 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1340271..1340669 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1340275) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1340685..1340924 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1340685..1340924 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1340903 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1340991..1340998 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1341009..1341028 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341014 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1341040..1341489 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1341040..1341489 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1341475 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1341544..1341816 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1341544..1341816 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1341621..1341844) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1341819..1341939 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1341819..1341939 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1341846..1341969) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1341889) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1341940..1342045 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1341970..1341982) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1341977) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1341997..1342003) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1342026..1342030 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1342046..1342065 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1342047..1342138 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1342047 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1342139..1342693 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1342139..1342693 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1342698..1343183 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1342698..1343183 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1343150 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1343194..1344420) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1343194..1344420) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1343195..1344469 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1344421..1344522) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1344444..1344451 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1344463..1344482 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1344471..1344600 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1344471 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1344517..1344535) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1344532) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1344552..1344557) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1344601..1345383 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1344601..1345383 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1345163..1345169 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345183..1345194 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345194 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1345385..1346410 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1345385..1346410 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1346294 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1346427..1347674) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1346427..1347674) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1346454) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1347591..1347597 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1347611..1347622 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1347615 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1347671..1347856) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1347671..1347856) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1347689..1347693 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1347709..1347728 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1347718..1347853 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1347718 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1347747..1347766) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1347757) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1347780..1347787) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1347824..1347831 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347845..1347864 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1347855 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1347884..1348402 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1347884..1348402 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1348424..1348603 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1348424..1348603 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1348583 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1348626) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1348630..1348633) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1348684..1348689 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1348705..1348723 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1348706 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1348749..1349330 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1348749..1349330 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1349331 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1349387..1349869) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1349387..1349869) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1349406) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1349859 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1349892..1349911) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1349911) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1349925..1349932) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1349969..1349975 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1349987..1350006 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1349989 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1350029..1350925 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1350029..1350925 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1350996..1352615 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1350996..1352615 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1352587 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1352649..1352652 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1352667..1352740 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1352667..1352686 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1352667 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1352724) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1352741..1353172 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1352741..1353172 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1353242..1354177 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1353242..1354177 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1353844..1355296) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1354217..1354570 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1354217..1354570 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1354567..1356717 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1354567..1356717 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1355277..1355295) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1355296) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1355310..1355316) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1356700 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1356772..1356777 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1356793..1356811 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1356793 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1356834..1358774 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1356834..1358774 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1358570..1358576 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1358591..1358599 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1358597 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1358747 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1358792..1358859 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1358829..1358833 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1358849..1358868 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1358861..1358949 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1358861 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1358950..1360434 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1358950..1360434 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1360435..1360545 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1360546..1361520 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1360546..1361520 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1361521..1362876 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1361521..1362876 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1362700..1362705 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1362721..1362739 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1362731 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1362937..1364037 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1362937..1364037 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1364038..1364159 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1364160..1365251 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1364160..1365251 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1364640..1364649 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1364662..1364677 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1364667 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1364673..1364773 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1364733 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1365283..1366194 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1365283..1366194 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1366212 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1366324..1367115 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1366324..1367115 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1367112..1367807 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1367112..1367807 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1367830..1368537 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1367830..1368537 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1368555..1368920 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1368555..1368920 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1368772..1368775 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1368791..1368810 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1368807 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1368921..1369093 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1369094..1370416 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1369094..1370416 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1369301) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1369305..1369309) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1369324..1369328) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1370452..1371600 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1370452..1371600 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1371574 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1371695,1371702) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1371696..1371701 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1371702..1371747 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1371712..1371719 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1371732..1371751 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1371749 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1371806..1372600 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1371806..1372600 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1372518..1372521 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1372536..1372555 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1372544 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1372613..1372714 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1372613..1372714 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1372701 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1372802..1374082 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1372802..1374082 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1374023..1374039) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1374028) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1374103..1374108 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1374124..1374142 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1374128 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1374165..1374410 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1374165..1374410 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1374326..1374334 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1374345..1374363 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1374353 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1374411..1374521 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1374513..1374532 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1374523 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1374573..1375409 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1374573..1375409 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1375416..1376108 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1375416..1376108 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1376105..1376560 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1376105..1376560 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1376567..1376839 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1376567..1376839 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1376828 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1376900..1377673 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1376900..1377673 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1377389..1377396 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377410..1377428 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1377433 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1377674..1377766 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1377767..1378261 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1377767..1378261 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1378274..1378281 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1378295..1378314 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1378302 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1378324..1378550 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1378324..1378550 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1378517 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1378603..1381368 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1378603..1381368 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1381359 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1381414) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1381449..1381455 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1381470..1381481 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1381470 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1381513..1381887 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1381513..1381887 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1381919..1381923 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1381938 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1381939..1381958 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1381990..1382454 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1381990..1382454 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1382456..1383367 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1382456..1383367 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1383362..1383369 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1383384..1383403 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1383398 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1383407..1383523 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1383407..1383523 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1383550..1384095 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1383550..1384095 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1383744) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1384086 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1384099..1384216 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1384099..1384216 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1384269..1385576 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1384269..1385576 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1385577..1385691 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1385577..1385691 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1385722..1386636 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1385722..1386636 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1386620..1387906 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1386620..1387906 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1387903..1388997 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1387903..1388997 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1388982..1392197 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1388982..1392197 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1392194..1392964 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1392194..1392964 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1392964..1393899 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1392964..1393899 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1393868..1394587 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1393868..1394587 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1394566..1395216 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1394566..1395216 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1395218 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1395263..1395335 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1395315..1395322 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395336..1395355 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395337 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1395361..1395466 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1395361..1395466 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1395467..1395627 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1395628..1396329 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1395628..1396329 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1396341..1397405 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1396341..1397405 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1397454..1398602 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1397454..1398602 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1397543) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1397555..1397559) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1397577..1397578) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1398615..1399208 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1398615..1399208 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1399209..1399306 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1399307..1400080 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1399307..1400080 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1399985..1399992 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400007..1400026 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400008 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1400083..1400868 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1400083..1400868 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1400849..1401337 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1400849..1401337 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1401317 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1401364) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1401377..1403095) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1401377..1403095) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1403117..1403136) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1403131..1403136 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1403131) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1403149..1403154) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403152..1403170 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1403156 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1403211..1405883 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1403211..1405883 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1404616..1404635) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1404627) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1404650..1404657) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1405889..1405908 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1405892..1405965 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1405892 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1405966..1406841 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1405966..1406841 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1406918..1407187 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1406918..1407187 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1406998..1407002) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1407003) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1407195..1407809 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1407195..1407809 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1407813..1408016 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1407813..1408016 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1408005 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1408097..1409317 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1408097..1409317 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1409156..1409731) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1409314..1411731 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1409314..1411731 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1409727..1409745) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409731) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1409759..1409765) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1411582..1411586 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1411602..1411621 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1411613 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1411758..1412240 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1411758..1412240 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1412245..1413198 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1412245..1413198 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1413185..1414528 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1413185..1414528 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1414532..1415623 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1414532..1415623 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1415630..1416394 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1415630..1416394 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1415683 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1416388..1418334 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1416388..1418334 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1418243..1418249 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418263..1418281 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1418279 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1418349..1419245 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1418349..1419245 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1419250..1419903 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1419250..1419903 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1419901..1419910 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1419924..1419943 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1419929 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1419976..1420620 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1419976..1420620 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1420381..1420387 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1420398 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1420402..1420420 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1420511..1420516 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1420532..1420550 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1420545 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1420621..1420691 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1420692..1420772 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1420692..1420772 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1420787 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1420832..1421204 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1420845..1421033) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1420845..1421033) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1420861) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1420907) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1421034..1421126) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1421108..1421127) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1421126) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1421143..1421146) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1421177..1421184 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1421199..1421217 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1421206 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1421245..1421248 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1421263..1421282 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1421271 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1421310..1421672 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1421310..1421672 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1421523) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1421688..1423349 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1421688..1423349 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1423350..1423439 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1423412..1423419 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1423433..1423452 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1423441 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1423488..1424150 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1423488..1424150 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1424176..1425078 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1424176..1425078 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1425056..1427104 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1425056..1427104 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1427140..1427147 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427162..1427181 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1427168 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1427213..1427779 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1427213..1427779 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1427793..1428794 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1427793..1428794 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1428813..1429766 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1428813..1429766 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1429759..1430499 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1429759..1430499 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1430530..1430534 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430550..1430569 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1430555 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1430583..1430816 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1430583..1430816 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1430797 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1430825..1430925 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1430885..1430955 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1430885 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1430956..1431705 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1430956..1431705 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1431677 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1431747..1431753 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1431765..1431784 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1431787 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1431806..1435366 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1431806..1435366 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1435300..1436370) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1435386..1436375 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1435386..1436375 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1436362 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1436412..1436897) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1436412..1436897) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1436415) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1436919..1436937) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1436935) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1436951..1436958) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1437000..1437006 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1437021..1437040 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1437023 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1437074..1437406 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1437074..1437406 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1437077) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1437420..1438760 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1437420..1438760 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1438761..1438865 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1438866..1439138 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1438866..1439138 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1439138..1439383 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1439138..1439383 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1439355 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1439400..1439504 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1439505..1439891 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1439505..1439891 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1439896..1440420 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1439896..1440420 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1440417..1441148 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1440417..1441148 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1441154..1441161 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1441175..1441194 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1441179 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1441227..1441268 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1441227..1441268 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1441288..1441635 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1441288..1441635 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1441637 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1441690..1441696 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1441709..1441777 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1441709 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1441710..1441729 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1441778..1442626 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1441778..1442626 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1442647..1442654 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1442667..1442685 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1442677 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1442697..1443464 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1442697..1443464 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1443496..1445226 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1443496..1445226 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1444733) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1444734..1444753) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1444768..1444775) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1445223..1445504 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1445223..1445504 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1445336 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1445505..1445624 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1445596..1445603 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1445617..1445636 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1445626 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1445677..1446834 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1445677..1446834 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1445749..1445849) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1445789) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1446863..1447765 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1446863..1447765 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1447755 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1447826..1448719 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1447826..1448719 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1448725..1448732 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1448747..1448766 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1448754..1448906 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1448754 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1448907..1450982 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1448907..1450982 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1450952 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1451014..1451019 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1451026 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1451035..1451053 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1451058..1452365 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1451058..1452365 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1452371..1452375 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1452392..1452411 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1452402 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1452433..1453347 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1452433..1453347 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1452472..1452476 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1452489 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1452492..1452511 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1453360..1453905 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1453360..1453905 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1453922..1455325 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1453922..1455325 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1455365..1456144 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1455365..1456144 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1456119 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1456163 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1456264..1456271 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1456284..1456302 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1456295..1456448 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1456295 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1456423..1456430 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1456445..1456464 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1456450 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1456524..1456913 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1456524..1456913 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1456913..1457365 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1456913..1457365 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1457366..1457367 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1457422..1458186 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1457422..1458186 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1458196..1458202 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1458215..1458718 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1458215..1458718 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1458217..1458228 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1458231 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1458714..1458720 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1458735..1458754 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1458737..1458861 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1458737 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1458862..1459602 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1458862..1459602 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1459584 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1459629..1459703 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1459704..1460585 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1459704..1460585 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1460586..1460730 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1460731..1461453 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1460731..1461453 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1461455..1462012 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1461455..1462012 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1461959) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1462001..1462004 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1462019..1462038 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1462037..1462142 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1462037 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1462143..1462925 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1462143..1462925 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1462929..1463738 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1462929..1463738 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1463719..1463726 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1463741..1463760 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1463742 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1463800..1464951 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1463800..1464951 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1464958..1466226 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1464958..1466226 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1466259..1467953 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1466259..1467953 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1467954..1468061 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1468062..1472375 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1468062..1472375 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1472376..1472440 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1472386..1472603 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1472386..1472603 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1472412..1472418 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1472433..1472444 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1472442..1472509 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1472442 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1472492..1472498 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1472511..1472704 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1472511 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1472512..1472531 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1472705..1473175 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1472705..1473175 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1473026) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1473210..1474325 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1473210..1474325 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1473272..1473372) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1473312) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1474339..1474614 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1474339..1474614 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1474616..1474918 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1474616..1474918 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1474938..1477088 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1474938..1477088 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1476983..1476989 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1476998 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1477004..1477022 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1477085..1477363 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1477085..1477363 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1477380..1477733 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1477380..1477733 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1477724 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1477815..1478744 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1477815..1478744 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1478529..1478536 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478550..1478569 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478559 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1478763..1479713 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1478763..1479713 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1479746..1479752 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1479753..1479869 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1479753 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1479767..1479786 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1479870..1480139 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1479870..1480139 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1480122 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1480167..1480252 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1480233..1480236 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480252..1480271 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480254 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1480312..1482429 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1480312..1482429 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1482212 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1482413 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1482458..1482546 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1482547..1483506 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1482547..1483506 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1482615..1482623) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1482618) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1482637..1482644) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1483110..1483115 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1483131..1483149 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1483136 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1483546..1484775 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1483546..1484775 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1484764 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1484804..1484809 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1484819 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1484825..1484843 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1484853..1485110 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1484853..1485110 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1485111..1485165 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1485138 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1485207..1485216 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1485226..1485295 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1485226 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1485230..1485249 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1485296..1486189 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1485296..1486189 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1486192..1486794 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1486192..1486794 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1486848..1486867 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1486848..1486919 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1486848 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1486920..1487960 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1486920..1487960 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1487961..1488051 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1488052..1489266 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1488052..1489266 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1489297..1490169 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1489297..1490169 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1489640..1490824) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1490176 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1490269..1490272 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1490286 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1490288..1490307 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1490347..1492014 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1490347..1492014 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1490811..1490829) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1490828) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1490845..1490850) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1492002 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1492069..1492075 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1492089..1492100 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1492090 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1492130..1492867 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1492130..1492867 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1492864..1493076 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1492864..1493076 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1493104..1493123 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1493118 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1493207..1495570 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1493207..1495570 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1495571..1495671 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1495632..1495639 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1495654..1495673 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1495672 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1495714..1496439 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1495714..1496439 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1496426 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1496495..1496501 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1496514 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1496516..1496527 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1496578..1497786 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1496578..1497786 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1497744 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1497855..1497862 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1497875..1497894 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1497897 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1497909..1497912 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1497928..1497940 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1497942 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1497966..1499246 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1497966..1499246 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1499243..1500529 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1499243..1500529 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1500379 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1500530..1500583 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1500584..1501312 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1500584..1501312 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1501328..1501334 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1501346 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1501348..1501359 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1501359) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1501370..1501384) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1501393..1501397) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1501393..1501650 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1501393..1501650 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1501635 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1501667) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1501708..1501711 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1501726..1501745 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1501726 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1501780..1502295 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1501780..1502295 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1502231..1502569 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1502231..1502569 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1502636..1503502 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1502636..1503502 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1502699..1502799 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1502759 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1503462 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1503552..1504133 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1503552..1504133 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1504151..1505401 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1504151..1505401 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1505402..1505528 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1505508..1505515 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1505530..1505549 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1505530 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1505574..1506620 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1505574..1506620 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1506632 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1506677..1506742 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1506714..1506723 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1506736..1506751 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1506744 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1506788..1507963 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1506788..1507963 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1507964..1508063 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1508037..1508044 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1508058..1508077 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1508065..1508238 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1508065 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1508239..1509801 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1508239..1509801 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1509778 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1509870..1510664 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1509870..1510664 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1510419..1510424 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1510440..1510458 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1510460 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1510708..1510713 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1510724..1510863 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1510724 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1510729..1510747 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1510756) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1510767..1510780) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1510789..1510793) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1510800) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1510864..1511124 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1510864..1511124 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1511076 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1511108) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1511120 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1511165..1511339 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1511323..1511330 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1511341 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1511345..1511364 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1511390..1512433 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1511390..1512433 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1512446..1513624 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1512446..1513624 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1513606 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1513704..1513707 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1513716 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1513722..1513741 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1513772..1515301 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1513772..1515301 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1515303..1515734 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1515303..1515734 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1515717 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1515865..1515870 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1515886..1515904 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1515894..1515995 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1515894 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1515996..1516541 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1515996..1516541 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1516535 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1516542) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1516599..1516602 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1516617..1516636 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1516621 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1516674..1519250 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1516674..1519250 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1519266..1521149 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1519266..1521149 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1521052..>1521184) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S611" downshifts 1521064 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1521074) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(1521184,1521191) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_028" N_region 1521185..1521190 /note="EcoRI site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs27_028" CDS complement(1521189..1521449) /gene="ymaG" /locus_tag="PG10_pseudo_BSU_17310" /old_locus_tag="BSU_17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /modified_by="User" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAP*" /label="PG10_pseudo_BSU_17310" gene complement(1521189..1521449) /gene="ymaG" /locus_tag="PG10_pseudo_BSU_17310" /old_locus_tag="BSU_17310" /modified_by="User" /label="PG10_pseudo_BSU_17310" promotor_-35 1521445..1521450 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1521466..1521484 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1521476..1521495) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1521486 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1521489) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1521508..1521517) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1521538..1521951 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1521538..1521951 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1522002 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1522008..1522027 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1522051..1522995 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1522051..1522995 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1522975..1522983 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1522994..1523012 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1522996 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1523035..1523256 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1523035..1523256 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1523046) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1523108..1523112) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1523112) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1523127..1523132) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1523256 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1523452..1523724 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1523452..1523724 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1523740..1523747 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1523761..1523780 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1523763 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1523806..1524036 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1523806..1524036 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1524037..1524113 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1524070 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1524115..1524222 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1524195..1524202 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1524216..1524235 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1524224 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1524279..1524671 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1524279..1524671 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1524631..1526733 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1524631..1526733 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1526751..1527740 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1526751..1527740 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1527700 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1527754..1528413) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1527769) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1527790..1528410 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1527790..1528410 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1528391 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1528426..1528430 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1528448..1528815 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1528448 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1528452..1528469 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1528458) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1528474..1529241) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1528474..1529241) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1529250..1529269) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1529273) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1529282..1529291) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1529395..1529400 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1529416..1529434 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1529416 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1529698..1529703 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1529720..1529738 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1529724..1529864 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1529724 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1529865..1530833 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1529865..1530833 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1530802 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1530897..1530905 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1530912 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1530916..1530935 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1530966..1532228 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1530966..1532228 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1532246..1533511 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1532246..1533511 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1533559..1533566 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1533581..1533600 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1533593 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1533621..1534028 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1533621..1534028 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1533627) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1534009..1534027 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1534034 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1534087) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1534087..1535421 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1534087..1535421 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1535398 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1535443..>1535492 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1535492..1535493 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1535493..1536245 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1535585..1535603) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1535603) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1535619..1535624) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1536246..1537637 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1536246..1537637 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1537668..1539269 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1537668..1539269 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1537784..1538089) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1538084..1538103) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1538089) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1538117..1538125) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1539267 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1539406..1540560) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1539406..1540560) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1539409) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1540459..1540637) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1540605..1540611 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1540620..1540639) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1540621..1540637 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1540631 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1540637) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1540654..1540657) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1540664..1540671 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1540686..1540705 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1540697..1540801 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1540698 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1540802..1542139 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1540802..1542139 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1542140..1542214 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1542171 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1542290..1543789 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1542290..1543789 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1543790..1544105 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1544063 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1544272..1544907) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1544272..1544907) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1544944..1544963) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1544953) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1544978..1544985) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1545095..1545102 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1545117..1545136 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1545119..1545317 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1545119 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1545318..1546733 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1545318..1546733 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1546723 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1546826) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1546835..1548019) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1546835..1548019) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1548020..1548099) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1548092..1548110) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1548103) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1548126..1548131) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1548411..1548418 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1548433..1548452 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1548441 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1548483..1548944 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1548483..1548944 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1548974..1549408 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1548974..1549408 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1549157..1549462) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1549255 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1549409..1550505 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1549464..1549749) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1549507) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1549744..1549763) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1549749) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1549775..1549780) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1550011) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1550011..1550271) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1550011..1550271) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1550292..1550311) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1550302) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1550324..1550333) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1550506..1550631 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1550506..1550631 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1550632..1550748 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1550675..1550839 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1550675..1550839 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1550723..1550732 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1550746..1550765 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1550750..1551060 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1550750 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1551041..1551048 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1551062..1551081 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1551062 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1551113..1551952 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1551113..1551952 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1551135..1551154) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1551156) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1551169..1551172) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1551912 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1552058) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1552059..1552365) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1552075..1552362) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1552075..1552362) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1552102) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1552189..1552197 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1552211..1552230 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1552213 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1552224..1552384 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1552356 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1552405..1553127) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1552405..1553127) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1552410) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1553152..1553171) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1553160) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1553162..1553286) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1553287..1553643) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1553287..1553643) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1553667..1553686) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1553684) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1553702..1553706) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1553883) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1553889..1554089) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1553889..1554089) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1554072 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1554111..1554130) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1554123) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1554143..1554152) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1554264..1554452) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1554264..1554452) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1554280) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1554421..1554428) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1554434) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1554481..1554500) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1554499) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1554515..1554522) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1554531..1554668 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1554531..1554668 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1554562..1554567 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1554582..1554600 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1554600..1554702 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1554600 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1554703..1555101 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1554703..1555101 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1555102..1555906 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1555166..1555600) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1555166..1555600) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1555182) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1555630..1555649) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1555646) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1555663..1555670) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1555907..1556095 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1555907..1556095 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1556096..1556181 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1556140 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1556210..1556216 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1556228..1556387 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1556228 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1556230..1556241 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1556388..1557950 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1556388..1557950 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1556691..1556710) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1556700) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1556725..1556732) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1557980..1559071 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1557980..1559071 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1559061..1560275 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1559061..1560275 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1560353..1560360 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1560375..1560394 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1560386 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1560422..1561228 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1560422..1561228 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1561036..1562134) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1561233..1561850 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1561233..1561850 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1561847..1563487 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1561847..1563487 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1562121..1562140) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1562134) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1562154..1562162) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1563127..1563893) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1563524..1563889 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1563524..1563889 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1563866 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1563886..1564166) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1563886..1564166) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1563895..1564026) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1563938) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1563986..1563995 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1564008..1564017) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1564009..1564028 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1564014 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1564016..1564114 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1564026) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1564028..1564158) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1564115..1564873 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1564115..1564873 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1564148 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1564164..1564183) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1564165) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1564198..1564205) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1564688..1564899) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1564852 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1564897..1565516 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1564900..1565439) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1564900..1565439) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1565440..1565454) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1565446) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1565468..1565474) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1565494..1565503 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1565516..1565531 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1565518 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1565557..1565991 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1565557..1565991 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1565849..1566196 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1565849..1566196 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1565992..1566324 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1566283..1566292 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1566304..1566319 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1566326..1566504 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1566326 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1566395..1566474 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1566395..1566474 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1566461 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1566533..1567150) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1566533..1567150) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1566534) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1567174..1567193) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1567195) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1567207..1567214) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1567230..1567237 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1567249 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1567251..1567270 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1567300..1567617 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1567300..1567617 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1567317..1567335) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1567320) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1567349..1567356) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1567636..1568289 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1567636..1568289 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1568292..1568299 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1568313..1568332 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1568326 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1568353..1568586 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1568353..1568586 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1568587..1568722 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1568690..1568697 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1568711..1568730 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1568724 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1568755..1570758 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1568755..1570758 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1568959..1568978) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1568976) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1570748 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1570760..1571418) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1570858 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1570859..1570878 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1570911..1571357 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1570911..1571357 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1571381..1571400 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1571389 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1571400..1571417) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1571418) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1571436..1571440) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1571443..1571661 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1571443..1571661 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1571673 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1571718..1572017 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1571735..1571908) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1571735..1571908) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1571748) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1571946..1571965) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1571953) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1571979..1571986) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1571988..1571996 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1572008..1572027) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1572008..1572026 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1572019..1572127 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1572019 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1572020) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1572042..1572049) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1572128..1572835 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1572128..1572835 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1572855..1572862 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1572874..1572893 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1572882 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1572924..1573286 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1572924..1573286 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1573304..1573307 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1573322..1573341 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1573333 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1573365..1573856 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1573365..1573856 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1573852 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1573887..1574315) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1573887..1574315) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1573904) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1574333..1574352) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1574345) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1574347..1574432) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1574366..1574373) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1574403..1574412 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1574422..1574531 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1574422 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1574425..1574444 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1574427..1574446) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1574432) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1574434..1574517) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1574461..1574464) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1574488 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1574549..1574941) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1574549..1574941) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1574562) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1574784..1574789 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1574805..1574823 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1574809 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1574919..1574923 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1574933..1574947 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1574948..1574967) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1574950 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1574963) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1574981..1574990) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1575022..1575168) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1575022..1575168) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1575043) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1575200..1575346) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1575200..1575346) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1575346..1575479 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1575346 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1575357..1575359 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1575362..1575373) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1575376) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1575388..1575394) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1575469..1575476 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1575481..1575573 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1575481 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1575491..1575510 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1575532) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1575574..1578303 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1575574..1578303 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1575594..1575598) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1575598) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1578304..1578374 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1578375..1578887 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1578375..1578887 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1578844 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1578913..1578919 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1578932 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1578934..1578945 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1578968..1579093 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1578968..1579093 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1578986) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1579107..1579113 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1579128..1579139 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1579130 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1579158..1579304 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1579158..1579304 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1579341..1579592 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1579341..1579592 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1579570 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1579613..1579618 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1579632..1579651 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1579636..1579727 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1579636 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1579728..1580093 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1579728..1580093 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1580109..1580408 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1580109..1580408 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1580384 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1580439..1580726) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1580439..1580726) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1580460) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1580526) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1580756..1580775) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1580768) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1580791..1580798) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1580814..1581395) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1580814..1581395) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1581396..1581526 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1581421..1581440) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1581438) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1581511..1581514 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1581528 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1581530..1581549 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1581565..1581972 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1581565..1581972 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1581968 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1582034..1582037 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1582052..1582071 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1582056..1582370 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1582056 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1582371..1584338 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1582371..1584338 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1584342..1586762 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1584342..1586762 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1586742 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1586770..1586959) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1586809..1586985) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1586809..1586985) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1586813) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1586960..1587370) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1586960..1587370) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1587343..1587362) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1587346) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1587377..1587384) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1587411..1587430) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1587412) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1587445..1587452) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1587459..1587478) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1587470) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1587492..1587501) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1587718..1587723 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1587736..1587755 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1587741 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1587754..1587818 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1587819..1589216 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1587819..1589216 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1589205 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1589250 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1589306..1590052) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1589429..1589436 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1589448 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1589449..1589468 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1589519..1591018 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1589519..1591018 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1590051..1590070) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1590074) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1590084..1590093) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1590966 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1591086..1591349 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1591086..1591349 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1591608) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1591608..1592876) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1591608..1592876) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1592877..1593006) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1593007..1594548) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1593007..1594548) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1594549..1594870) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1594860..1594879) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1594871) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1594894..1594897) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1595097..1595104 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1595117..1595136 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1595124 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1595143..1595589 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1595143..1595589 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1595596..1596489 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1595596..1596489 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1596106..1596125 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1596114 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1596562..1597158 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1596562..1597158 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1597148 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1597207..1598406) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1597207..1598406) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1598407..1598478) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1598466..1598477) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1598478) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1598492..1598498) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1598576..1600111) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1598576..1600111) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1598588) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1600122..1600904) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1600122..1600904) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1600925..1601824) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1600925..1601824) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1601839..1602060) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1601839..1602060) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1602075..1603409) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1602075..1603409) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1603419..1605068) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1603419..1605068) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1603468..1603568 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1603528 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1605112..1606254) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1605112..1606254) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1606273..1606291) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1606290) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1606307..1606312) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1606345..1606650) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1606345..1606650) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1606640..1606813) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1606640..1606813) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1606921..1608453) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1606921..1608453) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1606932) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1608488..1608507) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1608488) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1608520..1608529) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1608589..1608981) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1608589..1608981) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1608620) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1609009..1609020) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1609016) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1609034..1609040) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1609088,1609095) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1609089..1609094 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1609095..1609200) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1609185..1609204) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1609200) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1609218..1609225) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1609474..1610949) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1609474..1610949) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1609486) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1610983..1611960) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1610983..1611960) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1611989..1612007) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1612001) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1612019..1612027) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1612094..1613485) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1612094..1613485) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1612108) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1612254 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1613275..1613281 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1613295..1613313 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1613306..1613639 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1613306 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1613486..1613590) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1613550..1613650) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1613590) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1613612..1613617 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613633..1613651 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1613641 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1613699..1613706 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613719..1613738 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1613722 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1613771..1614316 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1613771..1614316 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1614300 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1614410..1614482) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1614410..1614482) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1614508) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1614535..1615080) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1614535..1615080) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1615120..1615139) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1615134) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1615153..1615160) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1615396..1615626) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1615396..1615626) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1615410) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1615652..1615671) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1615664) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1615683..1615689) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1615718..1615737) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1615728) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1615741..1615748 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1615762..1615781 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1615766 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1615811..1617574 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1615811..1617574 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1617555 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1617675..1618532) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1617675..1618532) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1618578..1618597) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1618598) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1618611..1618618) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1618660..1619649 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1618660..1619649 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1618716..1619674) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1619706..1621187) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1619706..1621187) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1619719) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1621204..1625766) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1621204..1625766) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1624227..1624327 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1624287 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1625767..1625838) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1625818..1625837) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1625835..1625842 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1625838) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1625852..1625859) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1625854 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1625857..1625876 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1625913..1626815 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1625913..1626815 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1626795 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1626867..1627982) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1626867..1627982) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1627979..1628872) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1627979..1628872) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1628877..1628896) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1628885 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1628895) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1628910..1628916) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1628925..1628943) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1628943) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1628959..1628964) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1629020..1629388) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1629020..1629388) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1629423..1629441) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1629446) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1629448..1629567) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1629453..1629461) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1629559..1629578) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1629567) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1629569..1629665) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1629593..1629600) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1629688..1630404) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1629688..1630404) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1629710) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1630442..1630461) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630451) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630477..1630480) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1630505..1630511 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1630525..1630543 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1630530 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1630555..1630860 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1630555..1630860 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1630844 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1630931..1631701 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1630931..1631701 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1631683..1631690 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1631702 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1631705..1631724 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1631745..1632278 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1631745..1632278 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1632279..1632364 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1632321 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1632357..1633601) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1632357..1633601) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1632366..1633105 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1632371) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1633602..1633694) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1633695..1635158) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1633695..1635158) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1635176..1636210) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1635176..1636210) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1636222..1636293) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1636265) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1636294..1636385) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1636294..1636385) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1636413..1636432) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1636425) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1636447..1636454) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1636467..1636474 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1636488..1636507 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1636492 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1636534..1638576 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1636534..1638576 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1638584..1638593 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1638606..1638621 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1638609 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1638643..1638936 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1638643..1638936 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1638916 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1638961..1639308) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1638992) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1639309..1639713) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1639309..1639713) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1639714..1639809) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1639799..1639814) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1639799..1639918) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1639799..1639918) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1639809) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1639827..1639836) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1639914..1639920 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1639934..1639945 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1639945..1640153 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1639945 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1639988..1640110 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1639988..1640110 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1640154..1640447 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1640154..1640447 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1640448..1640541 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1640498 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1640563..1642248) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1640563..1642248) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1640575) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1642249..1642336) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1642328..1642346) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1642336) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1642360..1642367) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1642505..1642514 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1642524 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1642527..1642546 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1642573..1644024 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1642573..1644024 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1644000 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1644061..1644759) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1644061..1644759) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1644076) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1644794..1644813) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1644813) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1644815..1645028) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1644827..1644834) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1645029..1645706) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1645029..1645706) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1645707..1648196) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1645879..1646916 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1645879..1646916 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1647113..1647119 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1647134..1647145 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1647146 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1647173..1647856 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1647173..1647856 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1648197..1648502) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1648197..1648502) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1648503..1648604) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1648583..1648602) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1648604) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1648617..1648624) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1648632..1648734) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1648674) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1648735..1649913) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1648735..1649913) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1649939..1649958) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1649958) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1649972..1649981) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1650036..1650524) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1650036..1650524) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1650061) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1650549..1650704) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1650549..1650704) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1650744..1651499) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1650744..1651499) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1651752..1651757 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1651773..1651791 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1651788 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1651807..1652163 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1651807..1652163 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1652122..1652361) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1652122..1652361) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1652164..1652600 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1652362..1652463) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1652464..1652961) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1652464..1652961) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1652962..1653061) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1653062..1653973) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1653062..1653973) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1653995..1654006) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1653997) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654021..1654027) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1654257..1654264 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1654273 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1654279..1654298 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1654320..1654802 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1654320..1654802 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1654812..1655066 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1654812..1655066 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1655067..1655171 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1655172..1655966 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1655172..1655966 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1655967..1656977 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1656090..1656962) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1656090..1656962) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1657063..1657941 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1657063..1657941 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1658054..1658113) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1658089) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1658114..1658545) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1658114..1658545) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1658565..1658584) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658573) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1658575..1658808) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1658598..1658604) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1658809..1658827) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1658809..1659441) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1658809..1659441) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1658815) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658843..1658848) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1659579..1659586 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1659601..1659620 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1659605 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1659667..1660587 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1659667..1660587 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1660098..1660117) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1660113) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1660132..1660139) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1660588..1661245 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1661084..1661446) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1661084..1661446) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1661507..1661719) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1661507..1661719) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1661758..1661765 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1661780..1661799 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1661783 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1661823..1662086 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1661823..1662086 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1662064 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1662463..1665063) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1662463..1665063) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1665064..1665173) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1665089..1665096 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1665111..1665130 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1665119..1665746 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1665119 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1665163..1665182) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1665173) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1665197..1665203) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1665219..1665678) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1665261) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1665723) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1665733..1666374) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1665733..1666374) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1666375..1666492) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1666469..1666488) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1666492) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1666502..1666504) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1666580,1666587) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1666581..1666586 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1666587..1666671 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1666587..1666664 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1666587..1666651) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1666587..1666671 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1666649 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1666682..1667014) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1666682..1667014) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1666696) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1667079..1667804) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1667079..1667804) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1667819..1668562) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1667819..1668562) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1668590..1668609) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1668609) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1668623..1668629) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1668640..1669215) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1668640..1669215) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1669221..1669922) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1669221..1669922) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1669952..1669971) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1669952) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1669956..1669971) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1669986..1669993) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1669986..1669993) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1669996) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1669999..1670481) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1669999..1670481) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1670520..1670537) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1670524) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1670535..1671476) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1670535..1671476) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1670568) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1671506..1671525) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1671514) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1671539..1671543) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1671547..1671556 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1671569..1671588 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1671577 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1671592..1671656 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1671628..1671633 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1671649..1671667 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1671658 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1671682..1672227 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1671682..1672227 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1672186 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1672254..1672577) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1672254..1672577) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1672261) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1672598..1672617) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672609) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1672630..1672637) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1672698..1672704 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1672715 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1672719..1672738 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1672771..1673448 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1672771..1673448 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1673440 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1673538..1674074) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1673538..1674074) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1673561) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1674101..1674120) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1674121) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1674134..1674141) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1674211..1674993) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1674211..1674993) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1674220) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1675015..1675033) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675034) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675047..1675053) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1675090..1675097 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1675112..1675131 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1675116 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1675164..1675661 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1675164..1675661 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1675668..1675671 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1675687..1675706 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1675689 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1675725..1676702 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1675725..1676702 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1676674 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1676799..1676806 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1676821..1676840 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1676828 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1676864..1677922 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1676864..1677922 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1677923..1677992 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1677976..1677982 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1677994..1678013 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1677994 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1678042..1679154 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1678042..1679154 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1679173..1679772 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1679173..1679772 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1679710 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1679754 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1679794..1680292) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1679830) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1680264..1680273 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1680276..1680294) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1680285..1680479 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1680285 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1680286..1680305 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1680292) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1680311..1680316) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1680367..1681230) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1680367..1681230) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1680380) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1680436 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1680468) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1680481..1681248 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1681226..1681230 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1681239..1681253 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1681250 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1681269..1681288) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1681282) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1681284..1681477) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1681300..1681306) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1681478..1683253) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1681478..1683253) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1683254..1683384) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1683377..1683579) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1683377..1683579) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1683429) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1683577..1683596) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1683595) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1683597..1683789) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1683609..1683616) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1683818..1684444) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1683818..1684444) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1683834) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1684478..1684497) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1684491) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1684511..1684518) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1684595..1685086) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1684595..1685086) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1684604) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1685098..1685116) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1685110) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1685130..1685136) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1685161..1685493) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1685161..1685493) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1685494..1685784) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1685509..1685514 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1685529..1685547 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1685531 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1685571..1685798 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1685571..1685798 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1685785..1686261) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1685785..1686261) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1685799..1686306 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1686262..1686364) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1686279..1686284 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1686299..1686317 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1686308 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1686328..1686591 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1686328..1686591 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1686344..1686363) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1686364) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1686366..1686891) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1686377..1686381) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1686596..1686829 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1686596..1686829 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1686816 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1686915..1687259) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1686915..1687259) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1686936) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1687260..1687332) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1687328..1687347) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1687332) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1687334..1687437) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1687361..1687366) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1687424..1687439) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1687437) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1687452..1687461) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1687580) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1687616..1687819) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1687616..1687819) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1687840..1687859) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1687858) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1687860..1687926) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1687875..1687882) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1687892..1687899 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1687911 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1687913..1687925) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1687913..1687932 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1687916..1688048 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1687937) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1688049..1689536 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1688049..1689536 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1688492..1688509) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1688498) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1688522..1688530) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1689522 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1689584..1689589 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1689605..1689623 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1689610 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1689637..1691535 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1689637..1691535 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1690580..1690599) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1690588) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1690613..1690622) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1691525..1692370 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1691525..1692370 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1692371..1693877 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1692403..1693740) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1692403..1693740) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1692414) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1693768..1693787) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693783) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1693785..1694943) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1693802..1693809) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1693861..1693864 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1693879..1693898 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1693879 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1693959..1694924 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1693959..1694924 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1694912 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1694974..1696227) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1694974..1696227) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1694988) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1696243..1699077) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1696243..1699077) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1699172..1699191) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699187) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1699189..1699305) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1699206..1699213) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1699306..1701222) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1699306..1701222) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1701233..1702147) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1701233..1702147) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1702151..1702170) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1702166) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1702187..1702191) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1702211..1702801) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1702211..1702801) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1702894..1704138) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1702894..1704138) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1702896) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1704201..1704219) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704214) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1704216..1704436) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1704232..1704239) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1704422..1704440) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704436) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1704452..1704460) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1704520..1705737) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1704520..1705737) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1704546) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1705770..1705789) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1705778) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1705803..1705810) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1705973..1706596) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1705973..1706596) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1706597..1706747) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1706623..1706629 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1706635 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1706643..1706654 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1706661..1706669 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1706677..1706777 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1706681..1706699 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1706692 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1706730..1706748) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1706737..1706822 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1706737 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1706747) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1706764..1706770) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1706798..1706805 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1706818..1706837 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1706824 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1706862..1708220 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1706862..1708220 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1707204..1707215) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707209) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1707229..1707235) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1708236..1709084 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1708236..1709084 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1708500..1708519) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1708507) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1708533..1708541) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1709047 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1709079) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1709110..1709775) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1709110..1709775) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1709124) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1709794..1710144) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1709794..1710144) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1710141..1710419) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1710141..1710419) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1710446..1710465) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1710462) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1710480..1710486) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1710495..1711391) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1710495..1711391) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1711233..1711242 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1711253 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1711256..1711275 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1711271..1711489 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1711415..1711434) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711435) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711446..1711453) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1711490..1711963 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1711490..1711963 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1711960 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1711998..1712234) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1711998..1712234) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1712006) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1712257..1712276) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1712272) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1712290..1712299) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1712319..1713653) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1712319..1713653) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1713654..1713789) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1713786..1713805) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1713796) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1713820..1713827) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1713885..1713892 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1713907..1713926 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1713910 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1713911..1714017 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1714018..1714407 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1714018..1714407 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1714417 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1714814..1715152) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1714814..1715152) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1715175..1715182 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1715196..1715215 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1715205 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1715209..1715281 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1715240..1715259) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1715243) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1715271..1715277) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1715282..1715890 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1715282..1715890 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1715880 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1715933..1716535) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1715933..1716535) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1716551..1717462) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1716551..1717462) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1717491..1717510) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717507) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717526..1717531) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1717583..1717586 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1717601..1717620 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1717603 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1717646..1717846 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1717646..1717846 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1717846..1719336 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1717846..1719336 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1718581..1718592) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1718585) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1718606..1718612) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1719324 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1719371..1720771) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1719371..1720771) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1719395) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1720542..1720551 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1720563..1720578 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1720577 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1720791..1720810) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1720811) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1720824..1720831) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1720870..1720879 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1720885 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1720892..1720911 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1720924..1721625 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1720924..1721625 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1721650..1721658 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1721672..1721691 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1721677 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1721713..1721964 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1721713..1721964 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1721985 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1722035..1722856) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1722035..1722856) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1722061) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1722857..1722938) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1722939..1723640) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1722939..1723640) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1723641..1723730) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1723715..1723734) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1723730) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1723750..1723754) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1723788..1723794 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1723809..1723820 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1723826 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1723842..1723967 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1723842..1723967 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1723965 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1724007..1724321) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1724007..1724321) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1724019) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1724342..1724360) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1724349) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1724371..1724379) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1724382..1724993) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1724382..1724993) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1725071..1725247) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1725071..1725247) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1725075) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1725086) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1725090..1725109) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1725125..1725128) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1725261..1725279) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1725282) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1725284..1725505) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1725295..1725300) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1725305..1725310 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1725325..1725343 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1725327 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1725366..1725509 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1725366..1725509 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1725506..1726186) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1725506..1726186) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1725510..1726521 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1726213..1726232) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726219) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1726246..1726255) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1726337..1726561) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1726337..1726561) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1726351) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1726602..1726621) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1726614) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1726648..1726926) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1726648..1726926) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1726923..1728338) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1726923..1728338) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1727594..1727597 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727613..1727632 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727618 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1728367..1729194) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1728367..1729194) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1729172..1730482) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1729172..1730482) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1730491..1731144) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1730491..1731144) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1731129..1731818) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1731129..1731818) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1731825..1733159) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1731825..1733159) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1733140..1733295) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1733140..1733295) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1733178..1733196) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733194) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733212..1733217) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1733289..1733522) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1733289..1733522) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1733296) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1733398..1733402 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733411..1733425 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1733426 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1733427..1733446) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733436) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733461..1733470) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1733482..1734261) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1733482..1734261) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1734290..1735570) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1734290..1735570) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1734938..1734956) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734954) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734970..1734977) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1735538..1735556) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735548) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735572..1735577) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1735635..1735940) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1735635..1735940) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1735768) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1735964..1735983) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1735979) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1735997..1736006) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1736076..1736085 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1736099..1736118 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1736099 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1736120) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1736122..1736136) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1736145..1736149) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1736145..1736546 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1736145..1736546 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1736553..1737506 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1736553..1737506 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1737496 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1737577..1738725) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1737577..1738725) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1737594) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1738738..1738742 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1738751..1738770) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1738758..1738777 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738760) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1738768 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1739029..1739037 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1739051..1739070 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1739054 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1739095..1740120 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1739095..1740120 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1739498 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1739500..1739504 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1739514..1739515 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1740112 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1740164..1740595) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1740164..1740595) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1740169) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1740596..1741129) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1740596..1741129) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1741133..1741139 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1741150..1741260 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1741150 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1741152..1741171 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1741157..1741176) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1741177) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1741192..1741193) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1741261..1741686 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1741261..1741686 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1741674 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1741719..1742950 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1741736..1743073) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1741736..1743073) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1743145..1743339) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1743145..1743339) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1743158) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1743352..1743915) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1743352..1743915) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1743925..1744692) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1743925..1744692) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1744716..1744735) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744733) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1744746..1744753) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1744770..1745351) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1744770..1745351) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1745352..1745467) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1745499..1745750) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1745499..1745750) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1745512) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1745773..1745792) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1745787) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1745836..1747104) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1745836..1747104) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1747138..1747157) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1747157) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1747169..1747176) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1747311..1747330 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1747314 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1747353..1748348 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1747353..1748348 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1748369..1749010 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1748369..1749010 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1749011..1750112 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1749049..1749669) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1749049..1749669) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1749075) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1749670..1750176) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1749670..1750176) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1750173..1750967) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1750173..1750967) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1751051..1751584) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1751051..1751584) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1751056) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1751514..1751519 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1751530..1752476 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1751532 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1751536..1751554 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1751602..1752213) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1751602..1752213) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1752245..1752264) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752264) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1752277..1752282) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1752433 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1752473..1753246) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1752473..1753246) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1752508) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1753288..1753722) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1753288..1753722) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1753300) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1753751..1753770) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1753762) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1753764..1753828) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1753784..1753791) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1753807) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1753829..1755505) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1753829..1755505) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1755506..1755696) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1755685..1755704) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755696) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755719..1755722) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1755794..1756927) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1755794..1756927) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1755810) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1756949..1756968) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1756952) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1756987..1757604) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1756987..1757604) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1757620..1758102) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1757620..1758102) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1758103..1758250) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1758241..1758259) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1758251) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1758270..1758278) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1758304..1758313 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1758326..1758341 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1758328..1758414 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1758328 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1758377..1758384 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1758399..1758418 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1758416 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1758445..1759350 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1758445..1759350 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1759385..1759404 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1759399 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1759400..1759580 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1759581..1760729 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1759581..1760729 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1759750..1760779) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1760725 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1760761..1760780) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760779) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1760795..1760803) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1760810..1760956 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1760810..1760956 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1760849..1760856 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1760870..1760889 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1760881..1760971 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1760881 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1760972..1761172 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1760972..1761172 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1761187 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1761224..1761406) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1761224..1761406) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1761232..1761537 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1761241) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1761467..1761485) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1761499..1761505) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1761503) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1761513..1761519 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1761534..1761545 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1761539 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1761562..1761831 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1761562..1761831 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1761686 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1761814 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1761859..1762041) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1761859..1762041) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1761879) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1762034..1762714) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1762034..1762714) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1762715..1762852) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1762731..1762736 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1762749..1762768 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1762754 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1762797..1763486 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1762797..1763486 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1762850..1762866) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1762853) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1762854..1763243) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1763224..1763243) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1763241) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1763255..1763263) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1763486..1763884 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1763486..1763884 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1763877..1763883 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1763898..1763909 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1763909 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1763926..1764054 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1763926..1764054 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1764055..1765035 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1764062..1764952) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1764062..1764952) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1764099) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1764974..1764993) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1764981) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1765005..1765011) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1765009 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1765053..1765199) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1765053..1765199) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1765069) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1765223) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1765224..1765235) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1765250..1765256) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1765274..1765531) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1765274..1765531) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1765551..1765570) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765566) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1765582..1765589) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1765596..1769177) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1765596..1769177) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1769178..1769249) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1769239..1769258) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1769249) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1769294..1769491) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1769337) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1769353..1769442) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1769353..1769442) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1769470..1769489) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769491) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769504..1769511) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1769513..1770019) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1769513..1770019) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1770023..1771120) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1770023..1771120) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1771138..1771149) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771141) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771164..1771170) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1771194..1772510) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1771194..1772510) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1771207) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1772507..1773091) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1772507..1773091) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1773180..1773280) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1773180..1773280) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1773187) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1773281..1773421) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1773422..1774927) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1773422..1774927) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1774863..1774963) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1774903) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1774915 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1774953..1774972) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774969) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774986..1774993) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1775039..1776031) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1775039..1776031) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1775057) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1776076..1776666) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1776076..1776666) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1776668..1777642) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1776668..1777642) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1777680..1778699) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1777680..1778699) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1778747..1778766) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778757) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1778778..1778785) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1778820..1778827 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1778841..1778920 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1778841 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1778842..1778861 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1778921..1779748 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1778921..1779748 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1779750..1780514 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1779750..1780514 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1780503 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1780545) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1780555..1782480) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1780555..1782480) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1782511..1782530) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782515) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1782517..1782581) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1782545..1782549) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1782582..1782773) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1782582..1782773) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1782792..1782810) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782801) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1782803..1783108) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1782826..1782831) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1782840..1782846 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1782861..1782872 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1782870 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1782937..1783089 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1782937..1783089 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1783099 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1783142..1784299) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1783142..1784299) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1783153) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1784387..1784787) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1784387..1784787) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1784397) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1784784..1784803) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784802) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1784818..1784824) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1784846..1785142) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1784846..1785142) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1785167..1785186) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1785177) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1785200..1785207) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1785220..1785849) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1785220..1785849) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1785815) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1785851..1786078) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1785851..1786078) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1786106..1786125) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1786121) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1786123..1786277) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1786139..1786147) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1786162..1786290) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1786162..1786290) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1786277) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1786279..1786390) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1786280..1786299) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1786315..1786319) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1786391..1787632) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1786391..1787632) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1787346..1787364) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1787355) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1787379..1787386) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1787648..1789897) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1787648..1789897) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1789913..1789932) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1789929) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1789946..1789952) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1790000..1790506) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1790000..1790506) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1790023) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1790550..1790569) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1790567) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1790583..1790590) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1790588..1790597 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1790611..1790630 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1790623 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1790644..1791063 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1790644..1791063 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1791064..1791214 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1791084..1791461) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1791084..1791461) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1791117) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1791459..1791604 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1791491..1791509) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1791510) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1791523..1791532) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1791605..1791624 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1791606 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1791649..1791837 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1791649..1791837 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1791853 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1791876..1792247) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1791876..1792247) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1791909) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1792259..1792278) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1792272) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1792291..1792296) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1792293..1792538) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1792293..1792538) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1792564..1792582) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1792569) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1792594..1792602) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1792688..1792694 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792709..1792720 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1792716 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1792737..1792841 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1792737..1792841 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1792823 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1792866..1793828) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1792866..1793828) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1792996..1793005 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1793017..1793032 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1793017 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1793021..1793356 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1793327..1793331 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1793347..1793366 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1793358..1793868 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1793358 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1793829..1794285) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1793869..1794489 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1793869..1794489 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1794274..1794285) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794285) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1794300..1794306) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1794511..1797255 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1794511..1797255 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1796925) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1797241 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1797331..1797825) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1797331..1797825) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1797344) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1797822..1798481) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1797822..1798481) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1798500..1799198) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1798500..1799198) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1799199..1799290) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1799291..1800583) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1799291..1800583) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1800584..1800645) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1800645..1800664) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1800645) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800679..1800686) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1800727..1801908) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1800727..1801908) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1800731) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1801931..1802416) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1801931..1802416) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1802364..1802383) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1802381) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1802396..1802403) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1802425..1802595) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1802425..1802595) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1802596..1802667) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1802629..1802635 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1802650..1802669) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1802650..1802661 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1802657..1802731 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1802657 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1802667) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1802669..1802737) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1802685..1802691) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1802701 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1802738..1805533) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1802738..1805533) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1803206..1803210 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1803207 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1803212..1803216 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1803863..1803878) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1803877) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1803891..1803900) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1805534..1805658) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1805659..1806042) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1805659..1806042) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1806044..1806904) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1806044..1806904) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1806906..1807739) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1806906..1807739) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1807740..1807947) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1807942..1807961) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807947) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1807978..1807982) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1807985..1808962) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1807985..1808962) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1808947..1810140) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1808947..1810140) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1810145..1811278) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1810145..1811278) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1811275..1811985) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1811275..1811985) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1811978..1812391) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1811978..1812391) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1812407..1813210) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1812407..1813210) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1813222..1813557) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1813222..1813557) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1813577..1813596) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1813587) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1813610..1813617) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1813626..1813633 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1813642..1813661) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1813647..1813666 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1813653 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1813661) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1813697..1814569 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1813697..1814569 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1814611..1815405) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1814611..1815405) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1814636) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1815406..1815473) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1815474..1816031) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1815474..1816031) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1816032..1816111) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1816156) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1816178..1816945) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1816178..1816945) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1816980..1817654) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1816980..1817654) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1817656..1818159) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1817656..1818159) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1818168 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1818223..1818242) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1818223) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1818257..1818264) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1818302..1818748) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1818302..1818748) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1818751 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1818803..1819342) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1818803..1819342) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1818816) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1819375..1819393) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1819386) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1819405..1819413) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1819414..1820685) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1819414..1820685) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1820686..1820753) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1820750..1820769) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820753) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820783..1820790) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1820820..1820839) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1820826) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1820828..1820972) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1820850..1820857) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1820954..1820972) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1820972) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1820988..1820993) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1821021..1822307) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1821021..1822307) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1821044) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1822318..1823433) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1822318..1823433) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1823482..1824564) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1823482..1824564) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1824575..1825378) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1824575..1825378) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1825063..1825082) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1825080) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1825094..1825101) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1825371..1826573) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1825371..1826573) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1826554..1827201) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1826554..1827201) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1826648) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1826824..1826827) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1826824) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1827044) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1827206..1827958 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1827206..1827958) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1827206..1827958) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1827239..1827241) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1827242 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1827348,1827351) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827362,1827364) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827364,1827366) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827389,1827391) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827391,1827395) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827397,1827399) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827406,1827408) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827421,1827423) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827424,1827426) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827429,1827431) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827439,1827441) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827442,1827444) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827445,1827447) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827451,1827453) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827477,1827479) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827509,1827511) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827562,1827564) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827610,1827612) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827625,1827629) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827643,1827645) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827652,1827654) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827664,1827666) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827729,1827731) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827739,1827741) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827747,1827750) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827767,1827769) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827783,1827785) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827811,1827813) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827826,1827828) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827851,1827853) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827868,1827870) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1827883,1827885) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1827951..1828967) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1827951..1828967) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1828939..1830486) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1828939..1830486) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1830565..1830696) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1830608) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1830687..1830706) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1830696) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1830702..1831085) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1830702..1831085) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1830721..1830728) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1831082..1832170) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1831082..1832170) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1831211..1831226) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1831224) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1831239..1831247) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1832170..1833342) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1832170..1833342) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1833377..1833396) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1833394) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1833409..1833416) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1833417..1834187) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1833417..1834187) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1834213..1834232) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1834230) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1834244..1834250) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1834262..1834423) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1834305) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1834424..1834873) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1834424..1834873) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1834916..1834935) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1834923) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1834948..1834955) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1834989..1836035) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1834989..1836035) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1835977..1836678) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1835977..1836678) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1836685..1837440) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1836685..1837440) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1837441..1837526) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1837515..1837534) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1837526) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1837545..1837552) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1837604..1837831) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1837604..1837831) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1837625) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1837853..1838425) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1837853..1838425) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1838454..1838473) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1838464) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1838466..1838549) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1838486..1838492) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1838594) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1838613..1838891) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1838613..1838891) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1838892..1839117) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1839099..1839118) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1839117) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1839135..1839140) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1839265..1840743) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1839265..1840743) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1839278) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1840744..1840905) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1840892..1840910) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1840917) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1840924..1841658) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1840924..1841658) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1840925..1840930) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1840950) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1841680..1841883) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1841680..1841883) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1841919..1841938) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841940) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841952..1841959) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1842005..1842204) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1842048) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1842179..1842198) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1842204) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1842212..1842221) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1842221..1843258) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1842221..1843258) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1843276..1844586) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1843276..1844586) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1844587..1844711) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1844697..1844716) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844711) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1844731..1844734) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1844740..1844934) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1844740..1844934) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1844931..1845824) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1844931..1845824) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1845821..1846420) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1845821..1846420) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1846293..1846299 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1846308..1846491 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1846310 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1846313..1846324 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1846431..1846449) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1846450) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1846465..1846470) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1846498..1846629 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1846498..1846629 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1846617 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1846672..1847721) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1846672..1847721) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1846692) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1847596) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1847734..1848882) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1847734..1848882) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1848063..1848066 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1848090 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1848156 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1848860 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1848883..1849022) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1849021..1849040) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849022) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1849024..1849114) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1849055..1849062) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1849115..1849789) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1849115..1849789) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1849790..1849867) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1849868..1850044) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1849868..1850044) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1850056..1850074) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850073) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1850089..1850095) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1850089..1850742) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1850089..1850742) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1850772..1850791) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850785) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1850807..1850811) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1850835..1852187) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1850835..1852187) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1850850) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1852222..1853139) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1852222..1853139) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1852610) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1852761..1852768) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1852764) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1853177..1853188) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1853186) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1853202..1853208) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1853278..1853934) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1853278..1853934) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1853292) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1853959..1853978) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1853974) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1854054..1855028) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1854054..1855028) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1854062) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1854882..1854887 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1854903..1854921 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1854913..1855106 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1854913 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1855064 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1855137..1856420) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1855137..1856420) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1855140) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1855178..1855184 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1855196..1855200 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1855196 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1856463..1856482) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1856484) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1856497..1856504) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1856576..1857160) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1856576..1857160) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1856578) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1857161..1857242) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1857235..1857254) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1857242) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1857268..1857275) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1857319..1858098) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1857319..1858098) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1858124..1858139) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1858135) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1858151..1858160) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1858184..1858627) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1858184..1858627) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1858201) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1858690..1859412) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1858690..1859412) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1858971) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1859363..1859932) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1859363..1859932) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1859681..1859699) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859697) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1859714..1859720) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1859951..1860697 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1859992..1861482) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1859992..1861482) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1861475..1862533) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1861475..1862533) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1861823..1861832 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1861843..1862633 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1861843 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1861845..1861864 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1862574..1862593) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1862597) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1862605..1862612) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1862611..1862617 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1862631..1862650 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1862635..1862704 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1862635 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1862684..1862691 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1862706..1862798 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1862706..1862725 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1862706 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1862799..1863047 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1862799..1863047 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1863031 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1863087..1863659) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1863087..1863659) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1863107) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1863651..1863958) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1863651..1863958) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1863660..1863764) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1863957..1863976) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863973) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1863990..1863996) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1864085..1864092 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1864103 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1864107..1864126 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1864156..1865733 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1864156..1865733 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1865715 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1865776..1866543) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1865776..1866543) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1865791) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1866045..1866657 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1866570..1866589) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866583) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866604..1866607) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1866617 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1866655..1867761) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1866655..1867761) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1866672) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1867697..1868281) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1867697..1868281) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1868075..1868080 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1868091 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1868095..1868099 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1868232..1868237 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1868249 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1868253..1868271 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1868289 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1868330..1868349) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1868334..1868441 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1868338) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1868362..1868369) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1868397 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1868426..1868484) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1868457) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1868485..1870254) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1868485..1870254) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1868541) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1870251..1870973) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1870251..1870973) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1870974..1871053) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1871054..1872229) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1871054..1872229) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1872249..1873877) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1872249..1873877) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1873874..1874413) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1873874..1874413) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1874414..1874507) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1874508..1875242) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1874508..1875242) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1875251..1875270) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1875274) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875285..1875289) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1875334..1875870) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1875334..1875870) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1875339..1875358) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1875343) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875373..1875380) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1875875..1876465) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1875875..1876465) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1876453..1877601) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1876453..1877601) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1877623..1877641) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1877630) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1877656..1877661) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1877724..1878263) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1877724..1878263) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1877737) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1878272..1878289) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1878287) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1878304..1878309) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1878318..1878911) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1878318..1878911) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1878901..1879656) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1878901..1879656) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1879500..1879509 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1879522..1879541 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1879531 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1879702..1879721) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879717) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1879735..1879742) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1879882..1879889 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1879900..1879919 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1879905 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1879937..1880461 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1879937..1880461 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1880475..1880849) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1880475..1880849) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1880491) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1880911..1880930) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1880923) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1880942..1880949) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1880962..1881426) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1880962..1881426) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1881297..1881301 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1881315..1881319 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1881318 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1881459..1882655) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1881459..1882655) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1882670..1883317) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1882670..1883317) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1883328..1884413) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1883328..1884413) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1884414..1884542) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1884543..1884687) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1884543..1884687) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1884704..1884723) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884714) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1884738..1884745) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1884807..1885151) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1884807..1885151) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1884822) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1885183..1885201) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885196) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1885210..1885215 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1885216..1885222) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1885230..1886152 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1885230 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1885231..1885249 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1885237..1885252) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885240) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1885242..1885308) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1885265..1885274) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1885303..1885311) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885308) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1885325..1885333) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1885386..1885940) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1885386..1885940) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1885396) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1885966..1885985) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885984) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1885986..1886385) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1885997..1886003) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1886207..1886443 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1886207..1886443 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1886386..1886592) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1886386..1886592) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1886625..1886644) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1886647) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1886701..1886955) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1886701..1886955) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1886835..1886844 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1886846..1887235) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1886846..1887235) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1886858..1887929 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1886858..1886877 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1886858 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1887213..1887416) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1887213..1887416) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1887825..1887941 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1887825..1887941 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1887892 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1888018..1888027 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1888040..1888059 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1888040 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1888082..1888294 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1888082..1888294 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1888288 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1888430) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1888430..1888861) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1888430..1888861) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1888862..1888948) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1888931..1888950) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1888948) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1888964..1888969) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1888998..1889007 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1889017..1889114 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1889017 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1889020..1889035 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1889115..1889987 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1889115..1889987 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1889894 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1889960 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1890017..1891336) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1890017..1891336) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1890037) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1891337..1891401) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1891397..1891416) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1891401) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1891431..1891438) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1891442..1892060) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1891442..1892060) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1892046,1892053) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1892047..1892052 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1892053..1892069) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1892070..1893239) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1892070..1893239) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1893268..1893279) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1893283) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1893293..1893299) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1893385) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1893394..1894209) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1893394..1894209) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1894222..1895406) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1894222..1895406) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1895455..1895474) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1895473) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1895475..1895566) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1895490..1895497) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1895567..1896457) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1895567..1896457) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1896465..1896692) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1896465..1896692) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1896595..1896614) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1896606) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1896628..1896635) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1896685) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1896694..1896712) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1896722..1896740) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1896728..1896734) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1896735) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1896757..1896762) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1896817) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1896817..1897266) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1896817..1897266) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1897290..1897309) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1897300) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1897302..1897378) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(1897325..1897329) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(1897379..1898023) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(1897379..1898023) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(1898054..1898072) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(1898071) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(1898087..1898092) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(1898124..1898339) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(1898124..1898339) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(1898204) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1898439..1899758) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(1898439..1899758) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(1898446) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(1899776..1901182) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(1899776..1901182) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(1901230..1901249) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1901239) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1901241..1901322) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(1901264..1901271) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1901323..1902750) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(1901323..1902750) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(1902795..1903784) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(1902795..1903784) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(1903785..1903864) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(1903846..1903865) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1903864) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1903866..1904186) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(1903880..1903887) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1903905..1903912 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1903925..1903944 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1903927 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 1903966..1904316 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 1903966..1904316 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(1904188..1904324) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(1904231) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(1904325..1905488) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(1904325..1905488) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(1905485..1906042) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(1905485..1906042) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(1905972..1906072) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1906012) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1906056..1906061 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1906077..1906095 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1906079..1906093) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 1906083 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 1906090..1906264 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(1906095..1906098) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(1906098) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 1906117..1906239 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 1906117..1906239 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 1906240..1906247 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1906261..1906280 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1906266 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 1906302..1907222 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 1906302..1907222 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 1907211 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1907254..1907478) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(1907254..1907478) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(1907311) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1907501..1907520) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1907508) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1907535..1907542) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1907557..1907564 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1907579..1907598 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1907586 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 1907640..1908557 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 1907640..1908557 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 1908532 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(1908597..1908836) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(1908597..1908836) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(1908608) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1908849..1909172) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(1908849..1909172) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(1908915..1908934) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1908916) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1908948..1908955) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1909169..1910200) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(1909169..1910200) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(1909196..1909215) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1909203) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1909226..1909233) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1910193..1910537) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(1910193..1910537) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(1910547..1911017) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(1910547..1911017) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(1911018..1911094) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 1911018 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1911069..1911088) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911094) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1911096..1911202) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(1911103..1911110) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911203..1911541) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(1911203..1911541) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(1911538..1912776) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(1911538..1912776) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 1911700..1911701 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1911711 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1911766 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1912801..1912819) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(1912810) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(1912836..1912841) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 1912881..1912884 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1912899..1912918 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1912908 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 1912942..1913148 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 1912942..1913148 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 1913631..1913634 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1913649..1913668 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1913665 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 1913697..1914929 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 1913697..1914929 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 1914776..1915138 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 1914776..1915138 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(1914955..1915134) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(1914988) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1915135..1915521) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(1915135..1915521) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(1915525..1916484) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(1915525..1916484) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(1916485..1916555) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(1916556..1917902) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(1916556..1917902) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(1917903..1917977) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(1917978..1918757) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(1917978..1918757) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(1918763..1919722) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(1918763..1919722) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(1919744..1919763) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1919763) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1919778..1919785) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1919819..1919826 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1919840..1920126 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 1919840 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1919842..1919861 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1919856..1920101 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 1919856..1920101 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 1920127..1920963 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 1920127..1920963 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 1920961 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1921004..1922647) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(1921004..1922647) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(1921016) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1922665..1922671 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1922678 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1922685..1922696 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(1922703..1922722) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1922708) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1922754..1922761 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1922775..1922794 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1922777 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1922819..1923835 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 1922819..1923835 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 1923822 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1923884..1923893 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1923906..1923921 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1923910 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1923945..1924706 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 1923945..1924706 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 1924614 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 1924702 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1924734..1924934) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(1924750..1924875) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(1924750..1924875) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(1924777) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1924868..1924900) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(1924868..1924900) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(1924928..1924947) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924934) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924960..1924967) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1924982..1925905) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(1924982..1925905) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(1925931..1925950) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925944) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1925964..1925969) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1926043..1926050 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1926064..1926083 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1926066..1926131 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 1926066 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 1926132..1927601 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 1926132..1927601 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 1927584 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 1927609..1927648 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(1927621,1927624) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1927629,1927630) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1927641,1927642) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 1927650 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1927724..1929133) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(1927724..1929133) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(1927741) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(1927814) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(1929197..1929215) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1929199) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1929243..1930487) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(1929243..1930487) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(1930488..1930762) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 1930508..1930515 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1930529..1930548 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1930529 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 1930560..1930847 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 1930560..1930847 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(1930744..1930763) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(1930764) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(1930779..1930782) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 1930878..1931705 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 1930878..1931705 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 1931522 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 1931698 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1931710..1932630) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(1931753) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1931823..1931829 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1931843..1931861 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1931852 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 1931885..1932613 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 1931885..1932613 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(1932654..1933769) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(1932654..1933769) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(1932675) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(1933787..1935310) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(1933787..1935310) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(1934893..1934912) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934915) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1934927..1934931) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1935303..1935725) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(1935303..1935725) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 1935754..1935761 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1935775..1935794 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1935789..1935942 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 1935789 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 1935899 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(1935927..1936457) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(1935927..1936457) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 1935944..1936579 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(1936474..1936485) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1936481) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1936500..1936506) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1936509..1937477) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(1936509..1937477) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(1936525) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1937548..1938270) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(1937548..1938270) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(1937559) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(1938263..1938922) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(1938263..1938922) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(1938923..1939002) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(1939003..1939770) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(1939003..1939770) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(1939820..1939839) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1939835) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1939854..1939861) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1940038..1940475) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(1940038..1940475) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(1940047) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1940499..1940518) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(1940520) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(1940533..1940540) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 1940573..1940579 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1940592 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1940594..1940612 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1940636..1941529 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 1940636..1941529 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 1941562..1941569 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1941585..1941604 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1941593 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 1941630..1942799 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 1941630..1942799 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 1942782 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 1942872..1943708 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 1942872..1943708 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 1943706 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1943770) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1943770..1945044) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(1943770..1945044) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(1945067..1946050) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(1945067..1946050) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(1946064..1947056) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(1946064..1947056) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(1947078..1948502) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(1947078..1948502) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(1948523..1949614) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(1948523..1949614) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(1949633..1950727) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(1949633..1950727) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(1950739..1951638) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(1950739..1951638) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(1951674..1951693) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1951679) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1951681..1951762) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(1951763..1953841) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(1951763..1953841) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(1953901..1953920) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953918) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1953928..1953935 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1953937..1953940) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1953949..1953968 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1953956 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 1953994..1954230 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 1953994..1954230 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 1954221 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1954272..1955177) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(1954272..1955177) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(1954275) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1955195..1956613) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(1955195..1956613) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(1955490..1955509) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1955507) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1956628..1957746) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(1956628..1957746) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(1957780..1958919) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(1957780..1958919) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(1958947..1959810) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(1958947..1959810) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(1959835..1961016) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(1959835..1961016) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(1960596) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(1960703..1960709) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1960706) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(1960930..1961030) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1960970) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1961063..1961081) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961081) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961097..1961102) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1961143..1961874) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(1961143..1961874) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(1961150) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1961897..1961916) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961908) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961931..1961934) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1961953..1962573) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(1961953..1962573) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(1962588..1962881) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(1962588..1962881) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(1962901..1962920) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1962907) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1962935..1962942) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1963137..1963144 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1963158..1963177 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1963175..1963380 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 1963175 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 1963189..1963341 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 1963189..1963341 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 1963349..1963356 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1963371..1963390 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1963382 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 1963414..1964532 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 1963414..1964532 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 1964517 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(1964559..1964729) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(1964602) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1964713..1964728) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964729) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1964731..1964859) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(1964740..1964749) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1964858..1964877) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964881) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1964891..1964899) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1964991) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1964997..1965800) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(1964997..1965800) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(1965843..1965861) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965849) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1965851..1966003) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(1965872..1965880) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1965999..1966018) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966011) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1966030..1966037) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 1966045..1966046 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(1966106..1967836) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(1966106..1967836) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(1966121) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1967873..1968322) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(1967873..1968322) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(1968323..1968408) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(1968420..1969265) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(1968420..1969265) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(1968453) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(1969262..1971163) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(1969262..1971163) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 1970371..1970377 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1970392..1970403 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1970400 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1971164..1971292) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(1971287..1971306) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1971292) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1971321..1971327) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1971338..1972228) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(1971338..1972228) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(1972218..1972472) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(1972218..1972472) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(1972469..1973815) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(1972469..1973815) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(1973816..1973952) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(1973953..1974804) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(1973953..1974804) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(1974816..1975211) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(1974816..1975211) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(1975254..1975273) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1975273) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1975275..1975437) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(1975475..1975882) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(1975475..1975882) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(1975482) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(1975903..1977255) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(1975903..1977255) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(1976784..1976803) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(1976791) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(1976818..1976824) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(1977267..1977746) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(1977267..1977746) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(1977805..1977824) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1977816) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977838..1977845) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1977902..1978558) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(1977902..1978558) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(1977909) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(1978559..1979248) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(1978559..1979248) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(1979241..1979861) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(1979241..1979861) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(1979567..1979585) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1979585) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1979601..1979606) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1979875..1981074) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(1979875..1981074) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(1981093..1981494) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(1981093..1981494) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(1981501..1981707) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(1981501..1981707) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(1981730..1982245) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(1981730..1982245) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(1982239..1983162) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(1982239..1983162) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(1983163..1983237) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(1983238..1983519) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(1983238..1983519) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(1983539..1983557) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(1983562) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(1983573..1983578) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(1983664..1984221) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(1983664..1984221) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(1983676) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1984246..1985307) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(1984246..1985307) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(1985304..1985750) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(1985304..1985750) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(1985799..1985818) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1985815) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1985831..1985838) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1985837..1986373) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(1985837..1986373) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(1986386..1986397) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(1986395) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(1986411..1986417) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 1986443..1986449 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1986462 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1986464..1986482 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1986519..1986522 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1986537..1986556 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1986548 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 1986600..1987556 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 1986600..1987556 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 1987596..1987991 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 1987596..1987991 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 1987874..1987974 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1987934 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1987977 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1987988..1988863) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(1987988..1988863) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(1988890..1988908) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988907) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1988924..1988929) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1988989..1989417) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(1988989..1989417) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(1989016) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1989452..1989471) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989460) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1989487..1989491) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1989517..1990353) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(1989517..1990353) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(1990377..1990396) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990388) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1990390..1990934) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(1990410..1990417) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1990434..1990439 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1990453..1990472 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1990453 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 1990464..1990543 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 1990544..1990924 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 1990544..1990924 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 1990860 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1990904 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1990959..1992425) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(1990959..1992425) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(1990979) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(1992418..1993764) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(1992418..1993764) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(1993794..1994882) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(1993794..1994882) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(1994956..1995155) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(1994956..1995155) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(1995006) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(1995156..1995226) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 1995159..1995164 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1995180..1995198 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1995184 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 1995194..1995323 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(1995212..1995231) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(1995226) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(1995245..1995252) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 1995324..1996997 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 1995324..1996997 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 1997018..1997812 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 1997018..1997812 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 1997348..1997349 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1997354 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 1997836..1997839 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1997855..1997874 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1997856..1997994 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 1997856 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 1997995..1998168 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 1997995..1998168 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 1998153..1998157 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1998170..1998189 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1998170 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 1998202..1998537 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 1998202..1998537 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 1998514 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 1998604 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(1998636) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(1998653,1998660) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 1998654..1998659 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 1998729..1998735 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1998736 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1998749..1998760 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1998779..1999105 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 1998779..1999105 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(1998922..1999146) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(1998965) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1999087 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1999147..1999326) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(1999147..1999326) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(1999345..1999363) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999360) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999378..1999384) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1999397..1999771) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(1999397..1999771) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(1999772..2000155) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(1999772..2000155) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2000181..2000528) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2000181..2000528) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2000512..2000943) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2000512..2000943) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2000933..2001229) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2000933..2001229) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2001243..2002214) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2001243..2002214) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2002267..2003337) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2002267..2003337) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2003355..2003374) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003371) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2003388..2003395) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2003520..2003748) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2003561) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2003749..2004702) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2003749..2004702) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2004726..2004745) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2004747) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2004759..2004765) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2004785..2004791 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2004806..2004824 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2004824 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2004845..2006173 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2004845..2006173 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2006174..2007148 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2006226..2007062) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2006226..2007062) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2007063..2007247) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2007149..2007219 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2007149..2007219 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2007286..2007666) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2007286..2007666) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2007292) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2007695..2007713) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2007714) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2007728..2007734) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2007753..2007758 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2007774..2007792 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2007783 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2007833..2007840 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2007855 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2007856..2007875 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2007898..2008143 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2007898..2008143 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2008040 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2008129 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2008174..2008929 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2008183..2008818) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2008183..2008818) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2008208) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2008840..2008859) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008857) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008873..2008880) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2008897..2008904 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2008919..2008938 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2008931 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2008951) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2008953..2008967) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2008975..2008979) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2008975..2009148 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2008975..2009148 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2009136 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2009180..2009494) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2009180..2009494) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2009181..2010248 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2009194) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2009497..2010558) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2009497..2010558) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2010620..2011750) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2010620..2011750) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2011758..2011776) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2011790) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2011792..2011797) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2011833..2013749) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2011833..2013749) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2011860) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2012865..2012871 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2012884..2013913 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2012884 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2012887..2012905 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2013750..2013816) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2013810..2013829) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2013816) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2013844..2013851) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2013866..2014831) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2013866..2014831) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2014842..2015057) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2014842..2015057) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2015058..2015166) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2015167..2016690) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2015167..2016690) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2016708..2016727) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2016721) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2016742..2016749) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2016780..2016953) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2016780..2016953) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2016807) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2016969..2016980) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2016981) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2016994..2017000) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017020..2017583) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2017020..2017583) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2017584..2017667) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2017668..2017817) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2017668..2017817) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2017714) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2017854..2017873) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017864) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017889..2017892) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017901..2018980) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2017901..2018980) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2018977..2019447) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2018977..2019447) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2019392..2019400 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019414..2019422 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2019415..2019588 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2019416 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2019483..2019502) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2019495) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2019514..2019521) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2019560..2019564 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019580..2019599 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2019590 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2019627..2019980 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2019627..2019980 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2019977..2020441 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2019977..2020441 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2020427 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2020470..2021252) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2020470..2021252) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2020481) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2021263..2022072) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2021263..2022072) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2022093..2022977) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2022093..2022977) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2022977..2023906) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2022977..2023906) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2023975..2024877) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2023975..2024877) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2024932) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2024940..2024956) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2024967..2024969) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2024986,2024988) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2025032..2027182) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2025032..2027182) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2025042) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2025776..2025794) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025784) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2025810..2025816) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2026471..2026490) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2026488) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2026504..2026513) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2027232..2027251) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027237) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2027267..2027271) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2027296..2028588) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2027296..2028588) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2028611..2028622) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2028622) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2028636..2028642) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2028695..2029303) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2028695..2029303) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2028710) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2029355..2029374) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029366) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2029368..2029436) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2029389..2029396) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2029427..2029445) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029436) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2029460..2029466) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2029482..2029964) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2029482..2029964) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2029965..2030257) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2030007..2030013 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2030028..2030047 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2030041 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2030074..2030841 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2030074..2030841 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2030255..2030273) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2030257) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2030259..2031195) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2030287..2030293) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2030842..2031272 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2031229 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2031240) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2031257..2031685) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2031257..2031685) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2031681..2031685 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2031695..2031709 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2031704 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2031708..2031727) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2031731) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2031742..2031749) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2031900..2031905 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2031921..2031939 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2031933 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2031962..2032261 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2031962..2032261 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2032274..2032281 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2032296..2032315 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2032307..2032383 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2032307 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2032384..2033517 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2032384..2033517 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2033498 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2033543..2033932) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2033543..2033932) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2033569) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2033963..2033974) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033967) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2033988..2033994) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2034007..2034014 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2034025..2034044 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2034026 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2034065..2034646 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2034065..2034646 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2034644 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2034689..2035297 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2034689..2035126) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2034689..2035126) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2034693) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2035127..2035221) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2035217..2035236) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035221) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2035251..2035258) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2035264..2036145) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2035264..2036145) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2036141..2036146 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2036162..2036180 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2036178 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2036183..2036202) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2036189) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2036191..2036518) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2036207..2036216 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2036223 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2036229..2036248 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2036261..2036515 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2036261..2036515 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2036502 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2036542..2037435) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2036542..2037435) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2036547..2037348 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2036563) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2037445..2038761) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2037445..2038761) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2038797..2038816) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2038808) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2038832..2038836) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2038865..2038874 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2038886 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2038888..2038907 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2038930..2039673 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2038930..2039673 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2039655 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2039677..2039684 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2039698..2039717 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2039700..2039795 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2039700 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2039796..2040740 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2039796..2040740 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2040711 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2040763..2041884) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2040763..2041884) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2040788) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2041877..2042527) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2041877..2042527) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2042528..2042636) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2042624..2042643) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042636) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2042638..2042751) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2042659..2042663) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2042784..2043146) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2042784..2043146) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2042796) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2043142..2043146 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2043154..2043168 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2043175 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2043183..2043202) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2043185) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2043187..2043308) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2043214..2043221) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2043297..2043316) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2043305..2043324 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2043308) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2043310..2043449) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2043311..2043415 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2043311 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2043330..2043336) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2043379..2043386 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2043400..2043419 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2043417..2045566 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2043417 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2043475..2044590) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2043475..2044590) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2043494) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2044591..2044788) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2044789..2046600) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2044789..2046600) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2046195..2046201 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2046211 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2046213..2046232 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2046240..2046536 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2046240..2046536 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2046634..2047128) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2046634..2047128) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2047101..2047119) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2047112) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2047129..2047242) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2047131..2047139) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2047137..2047142 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2047158..2047176 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2047173 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2047227..2047245) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2047242) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2047244..2047321) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2047261..2047266) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2047287..2047306) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2047321) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2047322..2047325) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2047382..2048194) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2047382..2048194) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2048220..2048858) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2048220..2048858) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2048859..2048990) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2048984..2049003) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2048991..2051030) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2048991..2051030) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2048993) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2049018..2049025) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2049037) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2049103) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2051023..2051910) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2051023..2051910) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2051993..2052167) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2051993..2052167) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2052027) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2052142..2052147 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2052163..2052181 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2052171..2052190) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2052173..2053585 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2052173 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2052183) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2052205..2052212) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2052207..2052974) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2052207..2052974) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2053011..2053154) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2053011..2053154) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2053155..2053301) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2053302..2054207) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2053302..2054207) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2054188..2054598) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2054188..2054598) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2054636..2054655) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2054647) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2054649..2054716) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2054670..2054673) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2054717..2055088) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2054717..2055088) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2055069..2055542) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2055069..2055542) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2055543..2057678) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2055543..2057678) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2057522..2057527 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2057542 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2057543..2057561 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2057757..2058716) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2057757..2058716) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2057772) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2058713..2059909) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2058713..2059909) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2058780..2058799) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2058785) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2058813..2058820) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2058860..2058878) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2058872) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2058893..2058899) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2059087) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2059101..2059112) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2059127..2059133) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2059928..2060209) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2059928..2060209) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2060266..2060685) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2060266..2060685) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2060280) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2060710..2061705) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2060710..2061705) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2061727..2063040) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2061727..2063040) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2063076..2063091) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2063093) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2063104..2063113) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2063171..2063617) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2063171..2063617) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2063184) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2063382) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2063632..2063805) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2063632..2063805) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2063741..2063745 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2063746 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2063866..2063885) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063881) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2063899..2063906) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2063924..2063929 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2063944 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2063945..2063963 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2063978..2064901 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2063978..2064901 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2064938..2066293) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2064938..2066293) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2064944) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2066293..2067063) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2066293..2067063) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2067086..2068021) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2067086..2068021) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2068046..2069173) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2068046..2069173) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2069090..2069093 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2069101 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2069174..2069351) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2069213..2069303 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2069213..2069303 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2069373..2071208) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2069373..2071208) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2069396) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2071232..2071795) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2071232..2071795) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2071796..2071866) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2071867..2072898) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2071867..2072898) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2072939..2072958) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072952) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2072973..2072980) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2072979..2074118) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2072979..2074118) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2073991..2074002) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2073995) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2074016..2074022) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2074171..2076009) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2074171..2076009) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2074193) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2076044..2076063) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076061) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2076079..2076083) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2076143..2076481) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2076143..2076481) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2076149) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2076498..2077703) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2076498..2077703) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2077723..2077741) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077735) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2077757..2077762) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2077766..2078872) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2077766..2078872) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2078900..2078911) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2078907) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2078926..2078932) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2078971..2078974 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2078987 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2078990..2079009 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2079001..2079075 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2079076..2079342 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2079076..2079342 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2079331 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2079357..2080400) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2079357..2080400) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2079402) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2080429..2080448) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2080440..2080589) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2080440..2080589) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2080441) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2080462..2080466) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2080464..2080803) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2080507) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2080576..2080582 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2080596..2080615 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2080597 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2080630..2080764 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2080630..2080764 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2080758 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2080804..2083134) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2080804..2083134) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2080821..2080840) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2080837) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2080854..2080863) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2083138..2083707) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2083138..2083707) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2083734..2083753) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2083744) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2083768..2083775) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2083774..2084391) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2083774..2084391) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2084412..2084417 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2084429 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2084433..2084451 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2084452..2084466) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084454) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2084456..2085303) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2084475..2084479) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2084475..2085296 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2084475..2085296 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2085291..2085310) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2085297..2085377 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2085304) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2085324..2085331) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2085337 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2085362..2086105) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2085362..2086105) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2085392) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2086102..2086458) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2086102..2086458) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2086476..2087036) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2086476..2087036) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2087026..2087595) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2087026..2087595) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2087607..2087897) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2087607..2087897) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2087891..2088733) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2087891..2088733) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2088725 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2088751..2089851) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2088751..2089851) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2089855..2090373) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2089855..2090373) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2090283..2090300) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2090297) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2090316..2090319) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2090374..2090935) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2090407) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2090598..2090605 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2090616..2090716 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2090616..2090635 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2090616 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2090666..2090924) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2090666..2090924) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2090717..2090875 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2090717..2090875 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2090876..2091122 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2090923..2090942) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2090934) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2090958..2090962) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2090986..2091133) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2091023) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2091079 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2091124..>2091201 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2091128..2091147) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091133) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091160..2091169) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2091201,2091203) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2091202 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2091203..2091645 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2091216..2091632) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2091216..2091632) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2091678..2092976) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2091678..2092976) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2092963..2093658) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2092963..2093658) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2093724..2093741) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2093733) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2093819..2093825 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093832..2093850 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2093847 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2093926..2095143 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2093926..2095143 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2094385..2094392 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2094407..2094426 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2094423 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2095062..2095310 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2095062..2095310 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2095239..2096286) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2095655..2096212 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2095655..2096212 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2096213..2096335 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2096288..2096702) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2096331) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2096703..2097227) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2096703..2097227) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2097075..2097082 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2097093..2097112 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2097107 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2097228..2097315) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2097310..2097329) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097315) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2097317..>2097453) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2097344..2097351) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2097453,2097460) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2097454..2097459 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2097512..2098042) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2097512..2098042) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2098088..2098107) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098111) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2098121..2098128) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2098177..2099157 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2098177..2099157 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2099431..2100747) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2099431..2100747) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2100748..2100861) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2100862..2101731) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2100862..2101731) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2101754..2101773) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101771) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101788..2101793) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2101838..2101839) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101846) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101876..2101877) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2101876..2102979 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2101876..2102979 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2102869..2102888 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2102875 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2103226) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2103252..2104085) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2103252..2104085) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2104115..2104134) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2104124) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2104290..2104294 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2104305..2104527 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2104305 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2104309..2104328 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2104528..2104791 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2104528..2104791 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2104779 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2104928..2105743 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2104928..2105743 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2106078..2106150) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2106121) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2106151..2106507) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2106151..2106507) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2106560..2106919) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2106560..2106919) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2107012..2107031) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2107022) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2107191..2107292) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2107191..2107292) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2107332..2107434) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2107374) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2107435..2107821) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2107435..2107821) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2107863..2107879) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2107879) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2108012..2108018 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2108033..2108044 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2108033 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2108070..2108315 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2108070..2108315 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2108333..2108701 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2108333..2108701 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2108720..2109856 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2108720..2109856 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2109875..2110072 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2109875..2110072 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2110088..2110387 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2110088..2110387 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2110378 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2110650..2111072) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2110650..2111072) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2111070..2111073 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2111089..2111108 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2111104..2111254 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2111104 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2111107..2111126) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111114) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2111140..2111147) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2111223..2111242) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2111231) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2111255..2111449 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2111255..2111449 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2111257..2111264) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2111467..2111474 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2111490..2111509 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2111494 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2111495..2111579 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2111580..2112629 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2111580..2112629 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2112697..2112704 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2112719..2112738 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2112732 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2112760..2113269 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2112760..2113269 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2113238 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2113283..2114388 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2113311..2115344) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2113311..2115344) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2113336) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2115253..2115420) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2115253..2115420) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2115345..2115500) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2115501..2116328) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2115501..2116328) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2116349..2117158) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2116349..2117158) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2117175..2117663) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2117175..2117663) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2117663..2118103) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2117663..2118103) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2118100 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2118140..2118158) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2118144) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2118293..2121100) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2118293..2121100) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2121316..2121335) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2121322) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2121647..2121787 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2121647..2121787 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2121768..2121787 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2121778 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2121826..2123214 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2121826..2123214 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2123203 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2123236..2123309) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2123278) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2123310..2123942) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2123310..2123942) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2123366) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2123996..2124015) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2124007) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2124021..2124027 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2124030..2124037) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2124041..2124060 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2124046 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2124095..2124922 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2124095..2124922 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2124918 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2125035..2125044 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2125057..2125072 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2125062 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2125118..2125618 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2125118..2125618 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2125618..2126475 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2125618..2126475 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2126493..2126504) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2126512) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2126519..2126525) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2126586..2128490 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2126586..2128490 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2128571..2128577 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2128593..2128611 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2128599 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2128624..2128914 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2128624..2128914 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2128915..2129030 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2129012..2129019 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2129032..2129157 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2129032 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2129033..2129051 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2129051..2129151 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2129051..2129151 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2129114 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2129158..2132322) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2129158..2132322) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2129174) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2130308..2130317 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2130331..2130350 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2130352 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2132338..2132922) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2132338..2132922) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2133145..2133687) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2133145..2133687) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2133688..2133773) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2133771..2133786) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2133773) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2133799..2133808) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2133842..2134058) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2133876..2134034) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2133876..2134034) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2133885) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2134056..2134075) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2134058) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2134060..2134190) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2134089..2134098) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2134191..2134340) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2134191..2134340) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2134334 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2134341..2134431) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2134433..2134652) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2134476) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2134598 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2134631..2134650) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2134652) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2134654..2134729) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2134665..2134672) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2134730..2135530) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2134730..2135530) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2135599..2135752) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2135642) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2135743..2135762) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2135752) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2135777..2135783) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2135793..2136161) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2135793..2136161) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2136162..2136258) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2136244..2136263) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2136248..2136251 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2136264) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2136267..2136286 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136269 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2136270..2136476 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2136279..2136283) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2136477..2139419 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2136477..2139419 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2139438..2139920 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2139438..2139920 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2139900 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2139956..2140186) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2139956..2140186) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2139976) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2140187..2140268) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2140269..2141408) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2140269..2141408) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2141410..2142333) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2141410..2142333) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2142326) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2142334..2142397) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2142398..2143093) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2142398..2143093) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2142833..2142852) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2142851) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2142865..2142874) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2143114..2143755) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2143114..2143755) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2143322..2143341) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143341) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2143358..2143361) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2143807..2143816 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2143813..2143832) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143819) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2143829..2143848 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2143838..2143902 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2143838 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2143848..2143851) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2143883..2143890 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2143904 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2143906..2143923 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2143948..2144151 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2143948..2144151 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2144158 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2144188..2144889) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2144188..2144889) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2144200) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2144954..2146708) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2144954..2146708) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2144982..2145001) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2144992) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2146023..2146038) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146026) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146051..2146060) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2146254..2146272) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146268) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2146287..2146294 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2146287..2146292) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2146309..2146328 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2146314 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2146762..2147235) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2146762..2147235) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2146769) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2147236..2147368) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2147350..2147369) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147368) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2147370..2147478) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2147383..2147390) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2147471..2147490) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147478) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2147486..2148121) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2147486..2148121) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2147506..2147510) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2147616..2147621 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2147637..2147655 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2147644 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2148128..2149396) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2148128..2149396) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2149415..2150344) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2149415..2150344) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2150350..2151003) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2150350..2151003) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2151004..2151108) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2151090..2151109) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151108) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2151125..2151129) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2151155..2152237) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2151155..2152237) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2151189) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2152253..2152272) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152273) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152287..2152290) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2152363) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2152368..2152649) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2152368..2152649) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2152428) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2152667..2153083) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2152667..2153083) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2152915..2152933) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152934) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152949..2152954) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2153091..2153357) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2153091..2153357) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2153245..2153253 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2153268..2153287 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2153276..2154465 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2153276 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2153358..2153418) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2153412..2153431) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153418) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2153442..2156078) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2153442..2156078) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2153445..2153452) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2155844..2155862) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2155860) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2155876..2155883) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2156079..2156157) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2156158..2156365) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2156158..2156365) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2156373..2156392) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2156388) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2156407..2156414) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2156409..2157470) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2156409..2157470) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2157379..2157384 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2157390..2157625 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2157391 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2157400..2157418 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2157487..2157498) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157488) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2157512..2157518) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2157626..2158354 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2157626..2158354 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2158082) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2158376..2159197 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2158376..2159197 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2159258..2159908 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2159258..2159908 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2159925..2160581 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2159925..2160581 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2160580 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2160616..2160747) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2160616..2160747) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2160634) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2160769..2160960) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2160769..2160960) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2160972..2161496) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2160972..2161496) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2161083) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2161087..2161098) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2161113..2161119) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2161467..2161478) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2161473) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2161493..2161499) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2161554..2163950) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2161554..2163950) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2161580) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2161800..2161806 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2161814 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2161821..2161832 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2161834..2162183 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2161935) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2163975..2164595) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2163975..2164595) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2164681..2165796) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2164681..2165796) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2164682) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2165827..2166966) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2165827..2166966) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2166533..2166552) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2166545) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2166566..2166573) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2166985..2167401) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2166985..2167401) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2167402..2167499) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2167484..2167503) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167499) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2167519..2167522) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2167547..2167554 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2167568..2167587 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2167576 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2167604..2168869 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2167604..2168869 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2168868 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2168911..2169675) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2168911..2169675) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2168929) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2169759..2169959) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2169759..2169959) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2169777) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2169946 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2169947..2169956 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2169957..2169976) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2169968) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2169989..2169996) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170011..2171789) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2170011..2171789) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2171803..2173077) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2171803..2173077) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2173167..2173399) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2173167..2173399) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2173197) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2173409..2173412 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2173423..2173442) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2173427..2173446 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2173429..2173713 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2173429 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2173442) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2173457..2173464) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2173459..2173629) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2173459..2173629) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2173660..2173671) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2173677) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2173686..2173692) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2173689..2173696 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2173710..2173728 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2173715 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2173762..2175318 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2173762..2175318 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2175297 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2175345..2175743) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2175345..2175743) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2175353) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2175797..2178001) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2175797..2178001) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2178030..2178049) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2178037) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2178039..2178129) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2178064..2178071) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2178093 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2178169..2178681) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2178169..2178681) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2178174) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2178687..2181047) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2178687..2181047) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2179151..2179170) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2179159) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2179184..2179193) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2181061..2181080) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2181072) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2181095..2181101) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2181114..2181437) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2181114..2181437) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2181458..2181476) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2181469) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2181491..2181497) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2181513..2182010) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2181513..2182010) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2182011..2182086) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2182080..2182099) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2182086) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2182113..2182120) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2182168..2184381) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2182168..2184381) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2182173) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2183940..2183945 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2183959..2183978 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2183967 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2184420..2184716) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2184420..2184716) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2184627 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2184717..2184795) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2184757..2184762 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2184779..2184797 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2184781..2184800) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2184781 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2184795) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2184797..2185715) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2184815..2184818) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2184832..2186388 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2184832..2186388 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2185701..2185719) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2185715) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2185731..2185739) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2186389..2187153 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2186392..2187048) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2186392..2187048) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2187067..2187078) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2187079) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2187092..2187098) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2187131..2187136 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2187152..2187170 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2187155 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2187183..2187635 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2187183..2187635 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2187619 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2187674) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2187692..2187958) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2187692..2187958) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2187995..2189140) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2187995..2189140) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2188047) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2188091) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2188093..2188112) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2188127..2188132) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2189167..2190195) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2189167..2190195) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2190225..2190425) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2190225..2190425) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2190418..2191422) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2190418..2191422) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2191433..2192038) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2191433..2192038) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2192057..2192076) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2192073) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2192075..2192176) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2192087..2192093) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2192177..2192689) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2192177..2192689) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2192718..2192729) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2192733) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2192737..2194044) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2192737..2194044) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2192744..2192750) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2193998) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2194068..2194086) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2194083) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2194101..2194107) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2194115..2195140) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2194115..2195140) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2195177..2195196) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2195197) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2195211..2195218) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2195266..2195273 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2195287..2195306 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2195295 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2195327..2195332 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2195341 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2195348..2195366 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2195378..2196025 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2195378..2196025 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2195700..2196033) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2196004 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2196035..2196232) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2196071..2196193) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2196071..2196193) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2196078) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2196241) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2196242..2196259) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2196266..2196273) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2196278..2196568 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2196278..2196568 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2196289..2196308 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2196289..2196436 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2196289 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2196575..2196715 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2196575..2196715 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2196704 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2196764..2196770 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2196778..2196878 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2196785..2196803 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2196786 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2196838 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2196879..2198333 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2196879..2198333 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2198334 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2198374..2199096) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2198374..2199096) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2198379..2198800 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2198390) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2199119..2199138) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2199136) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2199152..2199159) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2199199..2199795) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2199199..2199795) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2199214) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2199838..2199849) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2199840) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2199842..2199906) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2199864..2199870) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2199943..2201106) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2199943..2201106) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2199951) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2201107..2201182) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2201158..2201176) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2201182) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2201192..2201197) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2201223..2202329) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2201223..2202329) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2201905..2201923) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2201930) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2201939..2201944) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2202241 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2202242..2202245 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2202316..2203185) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2202316..2203185) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2202410 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2203139..2204734) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2203139..2204734) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2204762..2204769 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2204762..2204781) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2204783 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2204785..2204804 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204786) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2204796..2204803) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2204837..2206024 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2204837..2206024 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2204838..2204857) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204856) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2204872..2204881) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2205739..2205744 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2205753 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2205755..2205774 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2205984..2206526 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2205984..2206526 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2206509 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2206551..2207408) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2206551..2207408) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2206554..2207263 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2206571) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2207425..2207868) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2207425..2207868) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2207929..2209215) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2207929..2209215) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2209249..2209827) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2209249..2209827) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2209828..2209893) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2209878..2209897) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209893) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2209895..2210112) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2209905..2210027 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2209905..2210027 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2209911..2209918) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2210148..2210432) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2210148..2210432) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2210157) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2210445..2210783) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2210445..2210783) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2210786..2211094) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2210786..2211094) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2211108..2211183) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2211108..2211183) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2211195..2211214) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2211215) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2211228..2211235) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2211241..2212107) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2211241..2212107) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2212100..2212894) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2212100..2212894) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2212897 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2212903..2213003 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2212918..2212936) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2212929) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2212952..2212957) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2212963 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2213006 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2213041) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2213044..2213850) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2213044..2213850) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2213852..2214532) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2213852..2214532) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2214585..2215103) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2214585..2215103) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2215100..2215972) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2215100..2215972) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2216003..2217016) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2216003..2217016) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2217057) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2217069..2217087) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2217108..2217803) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2217108..2217803) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2217840..2218409) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2217840..2218409) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2218261..2218276) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2218270) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2218289..2218298) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2218448..2218467) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2218464) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2218481..2218487) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2218560) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2218562..2219560) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2218562..2219560) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2219607..2219626) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219615) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2219638..2219645) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2219683) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2219694..2220440) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2219694..2220440) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2220468..2220487) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220475) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220502..2220509) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2220580..2221872) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2220580..2221872) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2220585) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2221873..2221931) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2221932..2224574) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2221932..2224574) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2224575..2224633) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2224634..2224856) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2224634..2224856) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2224677) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2224885..2224904) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2224897) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2224899..2225007) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2224919..2224924) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2224961..2224970 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2224983..2225002 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2224984 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2225000..2225014) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225007) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2225022..2225026) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2225022..2225213 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2225022..2225213 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2225232..2226257) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2225232..2226257) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2225262) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2226290..2228017) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2226290..2228017) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2227619..2227622 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2227638..2227657 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2227644 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2228013..2228017 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2228026..2228040 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2228040 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2228055..2228073) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2228071) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2228089..2228094) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2228148..2229440) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2228148..2229440) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2228165) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2229470..2230444) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2229470..2230444) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2230441..2231229) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2230441..2231229) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2231219..2232163) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2231219..2232163) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2232196..2233026) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2232196..2233026) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2233034..2234401) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2233034..2234401) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2234465..2234484) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2234471) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2234473..2234562) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2234522..2234541 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2234530 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2234559..2234578) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2234562) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2234564..2234980) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2234589..2234597) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2234631..2235128 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2234631..2235128 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2234964..2234982) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2234980) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2234982..2235112) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2234998..2235004) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2235092..2235103) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2235112) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2235118..2235124) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2235150..2235737) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2235150..2235737) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2235178) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2235734..2238058) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2235734..2238058) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2238059..2238170) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2238155..2238174) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2238170) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2238188..2238195) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2238239..2239897) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2238239..2239897) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2238258) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2239941..2239959) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2239952) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2239975..2239980) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2240049..2241311) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2240049..2241311) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2240059) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2241312..2241401) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2241389..2241408) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241401) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2241403..2241534) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2241420..2241427) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2241579) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2241583..2242857) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2241583..2242857) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2242858..2243047) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2243034..2243053) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2243047) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2243068..2243072) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2243085..2244089) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2243085..2244089) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2244114..2244133) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2244132) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2244145..2244152) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2244208..2244807) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2244208..2244807) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2244229) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2244820..2246238) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2244820..2246238) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2246127..2246131 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2246146..2246150 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2246146 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2246288..2247385) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2246288..2247385) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2247406..2248962) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2247406..2248962) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2247802..2247805 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2247818..2250259 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2247818 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2247820..2247839 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2248949..2249977) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2248949..2249977) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2250001..2250519) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2250001..2250519) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2250240..2250243 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2250259..2250263 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2250261 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2250516..2252240) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2250516..2252240) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2252241..2252361) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2252362..2252608) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2252362..2252608) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2252405) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2252609..2252735) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2252717..2252736) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2252735) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2252737..2252867) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2252751..2252758) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2252862..2252881) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2252871) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2252895..2252898) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2252993..2253002 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2253016..2253035 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2253018 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2253056..2253391 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2253056..2253391 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2253385 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2253472..2253479 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2253493..2253512 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2253495..2253559 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2253495 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2253560..2254015 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2253560..2254015 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2254123..2254129 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2254143..2254161 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2254150 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2254199..2255020 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2254199..2255020 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2255013 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2255077 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2255084..2255157) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2255084..2255157) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2255118) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2255194..2255213) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255197) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2255227..2255234) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2255288..2255797) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2255288..2255797) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2255305) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2255813..2256409) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2255813..2256409) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2256422..2257159) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2256422..2257159) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2257241..2257260) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2257257) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2257270..2258370) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2257270..2258370) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2257275..2257280) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2257287) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2258393..2258411) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2258409) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2258426..2258431) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2258485..2259303) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2258485..2259303) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2258497) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2259311..2259751) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2259311..2259751) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2259794..2259813) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2259803) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2259805..2259947) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2259829..2259833) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2259992) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2259995..2260219) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2259995..2260219) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2260268 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2260270..2260288 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2260277..2260296) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260297) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2260310..2260319) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2260335..2260778) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2260335..2260778) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2260839..2261600) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2260839..2261600) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2260847) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2261603..2263363) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2261603..2263363) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2263397..2264005) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2263397..2264005) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2263775..2263782 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2263795..2263814 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2263797 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2264006..2264101) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2264091..2264110) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2264101) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2264103..2264724) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2264125..2264132) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2264240..2264244 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2264254..2264354 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2264261..2264280 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2264270 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2264298..2264744 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2264298..2264744 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2264314 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2264732 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2264770) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2264788..2266014) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2264788..2265279) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2264788..2266014) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2264788..2265279) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2266128) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2266140..2266319) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2266140..2266319) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2266172) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2266344..2266363) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2266351) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2266376..2266383) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2266384..2268156) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2266384..2268156) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2268183..2268202) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2268197) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2268216..2268223) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2268286) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2268292..2268606) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2268292..2268606) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2268632..2268651) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2268646) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2268648..2268857) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2268667..2268669) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2268751..2268861) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2268751..2268861) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2268847..2268865) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2268857) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2268880..2268886) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2268929..2270416) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2268929..2270416) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2270417..2270529) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2270510..2270529) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2270529) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2270544..2270551) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2270633..2271610) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2270633..2271610) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2270641) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2271646..2272419) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2271646..2272419) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2272434..2273210) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2272434..2273210) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2272499 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2273225..2273809) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2273225..2273809) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2273851..2273870) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2273851) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2273883..2273890) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2273914..2275596) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2273914..2275596) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2275625..2275644) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2275633) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2275721) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2275785..2276189) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2275785..2276189) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2275787) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2276204..2278561) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2276204..2278561) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2278582..2280294) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2278582..2280294) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2280295..2280367) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2280368..2280901) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2280368..2280901) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2280908..2281165) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2280908..2281165) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2281192..2281211) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281208) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2281223..2281230) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2281248..2281267 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2281255 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2281299..2282240 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2281299..2282240 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2281972..2281991) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281987) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2282005..2282012) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2282223 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2282255) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2282276..2284690) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2282276..2284690) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2282299) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2284706..2285740) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2284706..2285740) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2285741..2286061) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2285822..2286028 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2285822..2286028 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2286051..2286315 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2286051 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2286056..2286075) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2286058..2286072 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2286061) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2286090..2286093) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2286095..2286841) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2286095..2286841) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2286868..2286887) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2286874..2286880 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2286881) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2286894..2286905 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2286901..2286907) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2286908 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2286960..2287175 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2286960..2287175 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2287157..2288569) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2287186..2287193 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2287209..2287228 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2287217 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2287244..2288350 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2287244..2288350 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2288386..2288389 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2288405..2288424 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2288409 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2288453..2289865 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2288453..2289865 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2288555..2288574) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288569) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288587..2288596) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2289862..2291196 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2289862..2291196 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2290895,2290897) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2291194 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2291233) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2291235..2291477) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2291235..2291477) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2291478..2291649) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2291537..2291707) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2291537..2291707) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2291650..2293446) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2291650..2293446) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2291752..2291770) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291770) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2291782..2291790) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2293443 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2293471..2293490) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2293481) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2293505..2293511) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2293541..2293597) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2293565) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2293598..2295100) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2293598..2295100) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2294971) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2295075..2295175) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2295115) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2295119..2295964) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2295119..2295964) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2295965..2296906) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2295965..2296906) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2296942..2298243) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2296942..2298243) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2298274..2299458) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2298274..2299458) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2299455..2300273) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2299455..2300273) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2300251..2300940) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2300251..2300940) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2300957..2302639) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2300957..2302639) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2302653..2304143) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2302653..2304143) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2304236..2304255) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2304243) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2304245..2304320) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2304270..2304277) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2304321..2305292) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2304321..2305292) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2305293..2305421) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2305406..2305425) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2305421) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2305440..2305443) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2305489..2306574) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2305489..2306574) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2305503) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2306600..2306619) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2306623) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2306634..2306641) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2306692..2306701 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2306707 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2306713..2306728 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2306758..2307150 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2306758..2307150 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2307121 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2307166..2307472 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2307166..2307435) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2307166..2307435) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2307182) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2307351) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2307429 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2307492..2307851) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2307492..2307851) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2307505) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2307883..2308083) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2307883..2308083) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2308096..2308617) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2308096..2308617) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2308679..2308818) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2308679..2308818) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2308815..2308834) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308825) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2308827..2308891) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2308848..2308855) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2308873..2308892) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308891) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2308908..2308912) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2309010..2309017 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2309031..2309049 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2309031 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2309063..2309728 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2309063..2309728 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2309706 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2309760..2310455) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2309760..2310455) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2309782) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2309826) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2310477..2310917) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2310477..2310917) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2310939..2310958) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2310958) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2310974..2310977) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2311051..2311776) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2311051..2311776) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2311080) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2311754..2313535) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2311754..2313535) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2313619..2313622 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2313631..2313650) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2313636) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2313637..2313656 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2313644 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2313702..2314484 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2313702..2314484 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2314468 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2314518) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2314525..2316456) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2314525..2316456) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2316500..2316747) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2316500..2316747) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2316503..2316512) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2316503) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2316558) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2316758..2316777) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2316771) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2316773..2316853) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2316793..2316797) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2316854..2317699) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2316854..2317699) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2317719..2317737) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317725) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2317753..2317758) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2317778..2318419) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2317778..2318419) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2318453..2319388) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2318453..2319388) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2319416..2320834) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2319416..2320834) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2320863..2320882) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2320871) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2320897..2320900) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2320949..2321407) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2320949..2321407) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2320968) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2321408..2321555) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2321546..2321565) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2321555) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2321557..2321635) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2321580..2321583) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2321680) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2321681..2322061) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2321681..2322061) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2322062..2322216) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2322196..2322215) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2322203 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2322204..2322223 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2322216) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2322230..2322236) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2322294..2322305) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2322300..2323322) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2322300..2323322) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2322301) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2322320..2322326) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2323366..2323385) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2323397) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2323398..2323405) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2323528..2323908) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2323528..2323908) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2323552) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2323909..2324039) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2323964..2323968 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2323984..2324003 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2323985..2324091 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2323985 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2324029..2324048) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2324039) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2324063..2324070) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2324092..2325282 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2324092..2325282 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2324914..2324932) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2324930) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2324948..2324953) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2325306..2326148 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2325306..2326148 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2325921..2325926 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2325942..2325960 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2325943 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2326141 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2326181) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2326190..2326783) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2326190..2326783) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2326799..2327431) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2326799..2327431) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2327432..2327596) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2327597..2328427) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2327597..2328427) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2328450..2331092) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2328450..2331092) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2331147..2331166) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2331156) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2331180..2331187) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2331216..2331335) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2331259) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2331336..2333075) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2331336..2333075) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2333068..2333790) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2333068..2333790) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2333858..2333877) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333868) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2333870..2333970) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2333891..2333897) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2334002..2334940) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2334002..2334940) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2334015) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2334984..2336255) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2334984..2336255) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2336040..2336059) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2336052) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2336256..2336338) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2336338) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2336340..2336418) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2336340..2336359) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2336375..2336379) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2336419..2337537) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2336419..2337537) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2337032 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2337379..2337382 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2337387 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2337516 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2337538..2337744) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2337712..2337724 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2337723 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2337730..2337749) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337744) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2337764..2337768) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2337864) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2337871..2338335) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2337871..2338335) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2338348..2338367) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338362) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2338364..2339549) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2338364..2338369 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2338380..2338388) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2338384..2338402 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2338390 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2338432..2339547 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2338432..2339547 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2339518 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2339580..2339963) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2339580..2339963) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2339594) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2339964..2340055) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2340056..2341813) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2340056..2341813) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2341856..2342815) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2341856..2342815) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2342816..2342917) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2342906..2342925) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2342917) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2342941..2342945) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2342999..2343976) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2342999..2343976) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2343026) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2343961..2344833) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2343961..2344833) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2344795..2344800 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2344816..2344834 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2344820..2345994 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2344820 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2344834..2344917) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2344906..2344925) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344917) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2344919..2345071) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2344941..2344945) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2345073..2345167) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2345116) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2345168..2346400) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2345168..2346400) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2346401..2346517) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2346505..2346524) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2346517) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2346537..2349884) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2346537..2349884) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2346538..2346545) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2347549..2347558 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2347570..2347585 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2347570 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2347758..2347777) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2347777) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2347791..2347798) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2349915..2349934) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2349933) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2349948..2349955) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2349973..2349978 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2349990 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2349994..2350012 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2350024..2350365 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2350024..2350365 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2350362..2350865 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2350362..2350865 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2350898..2350901 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2350916..2350935 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2350916 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2350967..2351158 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2350967..2351158 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2350968) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2351134 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2351176..2352117) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2351176..2352117) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2351179..2351550 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2351211) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2351519..2351528 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2351542..2351561 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2351552..2351946 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2351552 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2351908..2351914 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2351930..2351949 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2351948..2352247 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2351948 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2352136..2352155) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2352152) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2352154..2352568) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2352170..2352173) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2352248..2352550 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2352248..2352550 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2352551..2354346 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2352569..2353888) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2352569..2353888) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2353914..2353933) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2353935) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2353948..2353953) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2354064..2354966) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2354064..2354966) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2354985..2356235) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2354985..2356235) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2356253..2356945) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2356253..2356945) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2356992..2358320) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2356992..2358320) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2358317..2358598) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2358317..2358598) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2358613..2359617) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2358613..2359617) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2359614..2360393) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2359614..2360393) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2360390..2361097) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2360390..2361097) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2361127..2361846) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2361127..2361846) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2361672..2361679 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2361694..2361713 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2361694 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2361868..2362680) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2361868..2362680) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2362694..2363503) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2362694..2363503) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2363517..2364053) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2363517..2364053) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2364090..2364097 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2364108..2364127) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2364111..2364130 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2364114..2364205 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2364114 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2364124) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2364141..2364148) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2364206..2365132 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2364206..2365132 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2364608..2365137) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2365182) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2365183..2365866) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2365183..2365866) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2365867..2365928) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2365929..2366696) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2365929..2366696) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2366741..2366760) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366763) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366776..2366778) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366823..2367059) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2366823..2367059) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2366908 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2366928) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2367019..2368404) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2367019..2368404) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2368401..2369612) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2368401..2369612) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2369613..2369690) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2369683..2369702) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2369689) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2369717..2369724) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2369782..2370294) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2369782..2370294) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2369800) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2370320..2370339) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2370328) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2370353..2370360) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2370379..2371566) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2370379..2371566) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2370394) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2371567..2371671) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2371656..2371675) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371671) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2371673..2371802) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2371691..2371695) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2371739..2371942) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2371739..2371942) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2371800..2371811) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371802) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2371826..2371832) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2371914..2372903) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2371914..2372903) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2371932) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2372964..2373467) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2372964..2373467) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2372970) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2373184..2373284 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2373244 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2373463 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2373490..2373509) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2373506) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2373523..2373530) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2373577..2374032) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2373577..2374032) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2373605) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2374046..2374726) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2374046..2374726) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2374138) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2374145..2374156) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2374171..2374177) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2374464) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2374739..2374757) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2374753) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2374772..2374777) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2374801..2375295) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2374801..2375295) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2374816) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2375308..2376315) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2375308..2376315) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2376339..2376354) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376356) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2376358..2376437) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2376366..2376375) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2376415..2376434 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2376425 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2376430..2376449) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2376434..2376500 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2376437) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2376465..2376469) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2376501..2377304 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2376501..2377304 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2377234 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2377292 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2377336..2378925) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2377336..2378925) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2377345) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2378945..2380534) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2378945..2380534) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2380580..2380597) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2380585) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2380613..2380619) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2380712) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2380713..2380922) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2380713..2380922) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2380918..2380922 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2380922 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2380931..2380945 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2380943..2380954) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2380954) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2380969..2380975) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2381016..2382221) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2381016..2382221) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2382225..2383370) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2382225..2383370) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2383371..2384514) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2383457..2383464 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2383475..2383564 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2383475 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2383477..2383496 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2383565..2384902 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2383565..2384902 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2384500..2384519) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384514) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2384534..2384541) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2384878 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2384997..2386685) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2384997..2386685) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2384998) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2386686..2386791) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2386768..2386776 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2386779..2386798) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2386787..2386806 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2386791) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2386791 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2386792..2386881 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2386793..2387352) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2386814..2386816) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2386882..2387688 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2386882..2387688 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2387356..2387375) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387369) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2387387..2387394) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2387638..2387684) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2387660) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2387685..2388308) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2387685..2388308) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2387689..2388031 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2388009..2388016 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2388031..2388050 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2388033..2388176 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2388033 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2388148..2388152 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2388168..2388187 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2388178..2388308 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2388178 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2388310..2388434 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2388310 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2388324..2388342) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2388326..2388345 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2388342) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2388353..2388361) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2388435..2388926 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2388435..2388926 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2388905 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2388964..2390703) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2388964..2390703) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2388982) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2390177..2390184 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2390198..2390216 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2390201 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2390203..2390798 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2390733..2390752) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2390741) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2390743..2391576) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2390779..2390786 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2390800..2390997 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2390800..2390819 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2390800 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2390857..2390989 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2390857..2390989 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2390998..2391600 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2390998..2391600 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2391523 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2391578..2391797) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2391586 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2391621) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2391633 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2391678..2391851 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2391793..2391811) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391805) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2391809 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2391826..2391832) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2391871..2393139) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2391871..2393139) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2391897) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2393163..2393436) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2393163..2393436) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2393184..2393327) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2393227) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2393434..2393453) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2393446) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2393466..2393473) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2393481..2395199) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2393481..2395199) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2395213..2395220 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2395227..2395246) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2395235..2395254 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2395241 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2395250) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2395260..2395266) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2395283..2395290 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2395304..2395323 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2395307 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2395360..2395992 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2395360..2395992 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2395565..2395573 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2395587..2395606 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2395593 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2396019..2396663 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2396019..2396663 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2396660..2397823 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2396660..2397823 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2397814 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2397834..2398562) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2397834..2398562) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2397870) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2398552..2399370) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2398552..2399370) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2399433..2400437) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2399433..2400437) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2399450) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2400472..2400491) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2400487) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2400489..2400597) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2400597..2400616) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2400597) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2400599..2400664) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2400630..2400636) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2400710) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2400713..2401789) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2400713..2401789) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2401830..2401849) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2401850) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2401852..2401952) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2401864..2401871) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2401886 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2401940..2401959) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2401952) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2401973..2401979) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2402025..2402351) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2402025..2402351) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2402034) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2402375..2402830) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2402375..2402830) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2402861..2403283) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2402861..2403283) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2403304..2403322) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2403317) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2403336..2403342) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2403356..2403374) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2403365) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2403385..2403393) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2403445..2404743) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2403445..2404743) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2403454) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2404768..2404787) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404769) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2404771..2404967) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2404800..2404809) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2404950..2404969) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404967) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2404981..2404987) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2404993..2407851) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2404993..2407851) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2407885..2407904) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2407895) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2407920..2407924) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2407994) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2408011..2408616) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2408011..2408616) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2408632..2409441) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2408632..2409441) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2409456..2409779) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2409456..2409779) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2409780..2409918) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2409818..2409934) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2409818..2409934) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2409905..2409924) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2409918) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2409926..2409933 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2409948..2409967 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2409953 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2410014..2410460 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2410014..2410460 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2410461..2411189 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2410515..2411588) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2410515..2411588) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2410534) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2411610..2411629) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2411614) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2411643..2411650) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2411685..2411688 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2411703..2411722 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2411708 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2411747..2412064 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2411747..2412064 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2412064 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2412117..2413817) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2412117..2413817) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2412136) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2413849..2413867) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2413856) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2413882..2413888) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2413899..2414669) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2413899..2414669) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2414670..2414758) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2414756..2414775) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2414758) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2414791..2414795) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2414815..2415456) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2414815..2415456) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2414825) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2414890) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2415482..2415501) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2415491) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2415493..2415941) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2415517..2415521) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2415600..2415606 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415621..2415632 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415628 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2415663..2415941 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2415663..2415941 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2415942..2416112 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2415942..2416556) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2415942..2416556) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2416090 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2416557..2416892) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2416884..2416903) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2416892) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2416918..2416925) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2416919..2419075) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2416919..2419075) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2418616,2418618) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2419101..2420030) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2419101..2420030) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2420079..2420993) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2420079..2420993) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2420756..2420774) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2420764) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2420788..2420794) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2421019..2421570) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2421019..2421570) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2421433..2421452 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2421436 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2421593..2421612) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2421605) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2421628..2421631) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2421653..2421660 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2421671..2421690 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2421674..2421685) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2421678 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2421688) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2421699..2421705) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2421719..2422654 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2421719..2422654 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2422630 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2422688..2424079) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2422688..2424079) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2422700) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2424080..2424520) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2424106..2424111 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2424125..2424144 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2424138 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2424176..2425474 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2424176..2425474 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2424497..2424516) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2424520) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2424531..2424537) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2425461 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2425514..2426671) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2425514..2426671) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2425539) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2425787..2425792 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2425807..2425825 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2425815 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2426668..2427378) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2426668..2427378) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2427392..2427407) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2427409) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2427419..2427428) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2427435..2427436 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2427448..2427553 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2427448 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2427456..2427466 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2427519..2427525 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2427540..2427559 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2427555..2427668 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2427555 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2427669..2427890 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2427669..2427890 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2427873 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2427942 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2428011..2428730) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2428011..2428730) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2428025) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2428796) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2428799..2430433) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2428799..2430433) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2430465..2430484) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2430481) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2430551..2430555 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2430571..2430590 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2430589 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2430635..2431897 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2430635..2431897 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2431898..2431996 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2431970..2431976 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2431992..2432010 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2431998..2432085 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2431998 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2432086..2433624 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2432086..2433624 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2433604 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2433661..2433843) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2433661..2433843) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2433680) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2433858..2433876) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433878) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2433892..2433897) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2433911..2434579) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2433911..2434579) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2434601..2435887) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2434601..2435887) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2435899..2436402) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2435899..2436402) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2436399..2437520) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2436399..2437520) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2437528..2438493) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2437528..2438493) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2438519) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2438520..2438539) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2438554..2438561) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2438649..2438656 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2438669 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2438672..2438691 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2438709..2441027 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2438709..2441027 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2441017 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2441068..2442564) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2441068..2442564) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2441070) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2442589..2443449) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2442589..2443449) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2443525..2443544) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2443534) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2443560..2443567) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2443656..2444417) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2443656..2444417) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2443685) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2444418..2444493) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2444494..2445681) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2444494..2445681) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2445750..2446757) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2445750..2446757) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2446760..2447455) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2446760..2447455) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2447452..2448621) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2447452..2448621) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2447488..2447495 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2447510..2447529 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2447528 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2448611..2449957) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2448611..2449957) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2449027..2449031 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2449046 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2449047..2449065 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2449947..2450723) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2449947..2450723) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2450724..2450816) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2450802..2450821) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450816) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450836..2450843) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2450933..2451832) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2450933..2451832) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2451855..2451873) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2451872) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2451884..2451892) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2451962..2451969 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2451985..2452004 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2451991 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2452050..2453084 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2452050..2453084 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2453033..2453040 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2453055..2453063 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2453072 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2453118..2454398 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2453118..2454398 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2454391..2455302 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2454391..2455302 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2455299..2456129 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2455299..2456129 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2456102..2456106 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2456122..2456141 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2456130 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2456149..2457447 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2456149..2457447 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2457428 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2457469..2457780) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2457469..2457780) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2457480) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2457804..2457823) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2457812) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2457838..2457845) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2457846 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2457897..2460311) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2457897..2460311) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2457901) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2460312..2460407) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2460421..2460635) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2460421..2460635) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2460452) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2460647..2460666) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460668) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2460672..2460677 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2460681..2460686) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2460693..2460711 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2460706..2461146 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2460706 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2460738..2461073) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2460738..2461073) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2461068..2461332) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2461317..2461336) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2461332) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2461351..2461358) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2461371..2461378 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2461392..2461411 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2461408 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2461410..2461477 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2461478..2462263 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2461478..2462263 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2462264..2462320 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2462500..2463693) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2462500..2463693) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2462520) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2463694..2463792) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2463773..2463792) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2463792) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2463806..2463813) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2463830..2463833 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2463848..2463867 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2463852 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2463882..2464628 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2463882..2464628 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2464523 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2464622 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2464665..2466605) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2464665..2466605) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2464676) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2466595..2467356) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2466595..2467356) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2467380..2467398) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2467399) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2467458..2468462) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2467458..2468462) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2467497) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2468455..2469150) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2468455..2469150) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2469174..2469192) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469186) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2469208..2469211) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469247..2470557) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2469247..2470557) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2469269) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2470547..2471242) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2470547..2471242) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2471257..2472234) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2471257..2472234) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2472264..2473250) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2472264..2473250) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2473120..2473129 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2473136 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2473142..2473157 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2473244..2474122) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2473244..2474122) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2474115..2474507) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2474115..2474507) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2474508..2474752) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2474541..2474678) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2474541..2474678) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2474676 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2474747..2474766) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474752) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2474780..2474787) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2474833..2475105) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2474833..2475105) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2474840) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2475145..2475156) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2475149..2475157 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2475149) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2475160 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2475171..2475177) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2475171..2475189 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2475200..2475205 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2475219..2475238 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2475226 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2475267..2476235 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2475267..2476235 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2476232..2476816 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2476232..2476816 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2476780 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2476806..>2476937) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2476806..>2476937) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2476847) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2476940..2476941 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2476941..2476956) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2476947..2476966) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2476956) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2476958..2477092) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2476978..2476985) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2477067..2477086) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2477092) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2477185..2478576) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2477185..2478576) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2477193) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2478577..2478711) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2478712..2480610) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2478712..2480610) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2479768..2479774 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2479789..2479800 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2479801 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2480611..2480734) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2480760..2481962) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2480760..2481962) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2480779) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2482005..2482016) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482011) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2482013..2482129) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2482030..2482036) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2482130..2482268) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2482130..2482268) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2482228 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2482277..2482296) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2482292) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2482313..2482317) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2482389..2482396 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2482408 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2482410..2482429 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2482465..2484048 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2482465..2484048 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2484037 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2484087..2484329) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2484087..2484329) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2484101) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2484381..2485154) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2484381..2485154) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2485155..2485245) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2485221..2485230 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2485234..2485253) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2485242 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2485243..2485262 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2485247) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2485268..2485275) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2485305..2486309 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2485305..2486309 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2486322..2487104 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2486322..2487104 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2486326..2487874) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2487079..2487891 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2487079..2487891 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2487876 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2487918..2488394) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2487918..2488394) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2487919) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2488424..2488443) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2488437) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2488439..2488573) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2488573) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2488575..2488586) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2488601..2488607) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2488603..2489007) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2488603..2489007) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2489035..2489054) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489052) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2489054..2489140) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2489067..2489076) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2489173..2489610) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2489173..2489610) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2489185) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2489627..2489645) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489645) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2489647..2489872) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2489660..2489666) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2489702..2489721 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2489703..2489879 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2489703..2489879 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2489704 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2489873..2490310) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2489873..2490310) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2489899 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2490329..2490348) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2490350) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2490359..2490367) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2490430..2490903) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2490430..2490903) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2490439) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2490526) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2490904..2491255) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2490975..2490982 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2490995..2491014 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2491000 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2491032..2491259 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2491032..2491259 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2491256..2491819) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2491256..2491819) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2491844..2491863) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2491859) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2491913..2492161) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2491913..2492161) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2491934) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2492189..2492208) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2492222..2492229) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2492226) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2492288..2492294 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2492308..2492319 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2492320 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2492366..2493697 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2492366..2493697 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2493741..2494781 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2493741..2494781 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2494775..2494781 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2494796..2494807 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2494806 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2494835..2494993 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2494835..2494993 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2494982 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2495012..2495899) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2495012..2495899) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2495035) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2495889..2497196) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2495889..2497196) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2497202..2497954) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2497202..2497954) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2497973..2498893) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2497973..2498893) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2498929..2498940) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2498930) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2498932..2499023) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2498954..2498960) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2499008 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2499009..2499028) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2499011..2499023 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2499023) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2499025..2499106) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2499043..2499050) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2499106) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2499115..2499134) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2499148..2499155) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2499173..2500288) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2499173..2500288) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2499216) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2500285..2501745) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2500285..2501745) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2501188..2501206) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2501192) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2501221..2501227) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2501834) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2501836..2502651) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2501836..2502651) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2502686..2503510) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2502686..2503510) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2502768..2502787) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2502768) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2502803..2502806) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2502934) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2502944..2502955) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2502970..2502976) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2503498..2505240) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2503498..2505240) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2505237..2506652) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2505237..2506652) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2506653..2506765) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2506745..2506764) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2506765) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2506767..2506917) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2506780..2506783) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2506878..2506884 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2506898..2506917) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2506898..2506909 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2506906 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2506917) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2506931..2506940) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2506942..2507661 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2506942..2507661 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2507012..2507669) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2507650 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2507670..2508488) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2507670..2508488) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2508509..2508528) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2508523) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2508543..2508551) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2508589..2508597 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2508610..2508629 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2508611 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2508660..2509946 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2508660..2509946 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2509943..2510893 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2509943..2510893 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2510896..2512119 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2510896..2512119 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2512043) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2512120..2512687 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2512193..2512624) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2512193..2512624) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2512219) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2512626..2513681) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2512626..2513681) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2513696..2514829) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2513696..2514829) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2514862..2514881) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514881) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2514894..2514903) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2514967..2514976 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2514990..2515009 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2514992 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2515019..2516092 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2515019..2516092 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2515316..2515322 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2515333 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2515336..2515347 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2516081 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2516119..2516125 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2516140 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2516141..2516159 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2516172..2516639 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2516172..2516639 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2516611 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2516670..2519066) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2516670..2519066) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2516685) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2519053..2520507) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2519053..2520507) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2520504..2521535) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2520504..2521535) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2521559..2522701) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2521559..2522701) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2522698..2524581) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2522698..2524581) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2523407..2524826 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2524613..2524628) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524626) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524643..2524648) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2524693) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2524814..2524885) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2524814..2524885) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2524911..2525001) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2524911..2525001) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2525005..2525079) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2525005..2525079) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2525090..2525166) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2525090..2525166) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2525182..2525255) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2525182..2525255) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2525266..2525341) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2525266..2525341) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2525359..2525434) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2525359..2525434) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2525447..2525523) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2525447..2525523) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2525535..2525611) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2525535..2525611) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2525629..2525721) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2525629..2525721) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2525728..2525804) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2525728..2525804) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2525807..2525883) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2525807..2525883) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2525903..2525975) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2525903..2525975) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2525981..2526057) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2525981..2526057) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2526073..2526149) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2526073..2526149) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2526159..2526244) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2526159..2526244) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2526259..2526333) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2526259..2526333) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2526339..2526425) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2526339..2526425) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2526436..2526511) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2526436..2526511) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2526549..2526624) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2526549..2526624) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2526657..2526732) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2526657..2526732) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2526753..2526870) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2526753..2526870) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2526926..2529853) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2526926..2529853) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2530021..2531575) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2530021..2531575) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2531377,2531379) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2531576..2531867) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2531703..2531711 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2531709 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2531819 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2531840..2531859) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2531867) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2531869..2532835) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2531873..2531880) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2531992..2531995 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2532007 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2532010..2532029 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2532040..2532141 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2532040..2532141 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2532140 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2532241..2532819 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2532241..2532819 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2532809 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2532861..2533382) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2532861..2533382) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2532879) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2532951) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2533400..2534929) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2533400..2534929) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2534950..2535474) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2534950..2535474) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2535518..2535533) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2535524) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2535526..2535613) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2535545..2535554) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2535598..2535616) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2535608 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2535612..2535631 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2535613) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2535631..2535636) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2535642..2536130 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2535642..2536130 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2536107 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2536136..2536714) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2536136..2536714) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2536152..2536543 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2536163) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2536748..2536767) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2536757) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2536781..2536788) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2536802..2538010) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2536802..2538010) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2536823) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2537779..2537798) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537791) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2537813..2537820) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2538027..2539499) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2538027..2539499) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2539550..2539569) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2539551) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2539584..2539591) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2539611..2539617 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2539631..2539650 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2539646 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2539698..2540240 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2539698..2540240 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2540223 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2540317..2540324 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2540337..2540437 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2540337 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2540339..2540358 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2540438..2540983 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2540438..2540983 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2540970 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2541075..2541082 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2541096..2541115 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2541103 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2541108..2541276 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2541108..2541276 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2541257 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2541349..2542017 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2541349..2542017 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2542024..2543361 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2542024..2543361 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2543347 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2543397..2543660) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2543397..2543660) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2543415) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2543700..2543719) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2543702) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2543732..2543739) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2543769..2544617) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2543769..2544617) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2544662..2544681) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2544672) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2544696..2544703) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2544778..2546313) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2544778..2546313) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2544787) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2545971..2546071 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2546031 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2546097 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2546314..2546481) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2546470..2546489) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546481) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2546483..2547360) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2546504..2546511) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2546723..2546732 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2546746..2546765 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546746 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2546798..2547283 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2546798..2547283 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2547284..2547570 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2547390..2547462) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2547390..2547462) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2547405) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2547449) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2547473..2547492) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2547493) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2547507..2547510) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2547527 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2547570..2548400) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2547570..2548400) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2547581) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2548401..2548492) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2548493..2549659) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2548493..2549659) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2549655..2549659 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2549667..2549681 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2549683..2549702) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2549683 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2549702) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2549716..2549723) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2549781..2549788 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2549794 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2549799..2549818 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2549841..2550854 /gene="iolU" /locus_tag="PG10_BSU_31170_3'_ext" /old_locus_tag="BSU_31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /modified_by="User" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQANSCQSA FSH*" /label="PG10_BSU_31170_3'_ext" gene 2549841..2550854 /gene="iolU" /locus_tag="PG10_BSU_31170_3'_ext" /old_locus_tag="BSU_31170" /modified_by="User" /label="PG10_BSU_31170_3'_ext" downshifts 2550798 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR join(2550823,2550830) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_029" N_region 2550824..2550829 /note="EcoRI site (GAATTC)" /created_by="User" /label="IIG_Bs27_029" CDS complement(2550851..2552203) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2550851..2552203) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2550862) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2551018..2551036) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551035) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2551052..2551057) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2552176) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2552179..2552190) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2552235..2552254) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2552241) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2552243..2552314) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2552269..2552272) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2552315..2553487) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2552315..2553487) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2552650..2553571 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2553520..2553539) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2553533) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2553556..2553559) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2553591..2554754) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2553591..2554754) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2553606) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2554769..2554788) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2554787) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2554789..2554944) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2554803..2554810) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2554840..2554846 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2554861..2554879 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2554871 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2554872..2554930 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2554917..2554923 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2554919..2554930) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2554932 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2554937..2554948 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2554944..2554950) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2554944) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2554946..2555257) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2554984..2555220 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2554984..2555220 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2555180 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2555246 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2555298..2555690) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2555298..2555690) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2555302) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2555732..2555751) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2555739) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2555741..2555891) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2555767..2555771) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2555794..2555800 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2555807..2556791 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2555807 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2555815..2555833 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2555892..2557052) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2555892..2557052) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2556944..2556950 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2556962 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2556964..2556968 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2557053..2557553) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2557053..2557553) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2557583..2557602) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2557589..2557595 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2557604) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2557610..2557621 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2557610 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2557613..2557620) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2557622..2557700 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2557701..2558522 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2557701..2558522 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2558502 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2558549) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2558551..2558811) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2558551..2558811) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2558801..2558804 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2558819..2558838 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2558831 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2558832..2558897 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2558837..2558856) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2558842) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2558868..2558874) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2558898..2560061 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2558898..2560061 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2560124..2560130 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2560142..2560161 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2560152 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2560187..2561473 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2560187..2561473 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2561189..2561931) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2561468..2561475 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2561489..2561508 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2561490 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2561519..2561905 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2561519..2561905 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2561887 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2561932..2562549) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2561932..2562549) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2562584..2562602) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562601) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2562603..2564691) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2562617..2562622) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2562665..2562668 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2562683..2562702 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2562694 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2562760..2563938 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2562760..2563938 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2563976..2563982 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2563994..2564013 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2563999 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2564031..2565905 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2564031..2565905 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2564671..2564690) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564691) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2564704..2564713) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2565926..2566339 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2565926..2566339 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2566331 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2566542..2567099) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2566542..2567099) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2566563..2566582 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2566573 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2566583) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2566595..2567276 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2567125..2567144) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2567133) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2567160..2567164) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2567277..2568878 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2567277..2568878 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2568871..2569578 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2568871..2569578 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2569563 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2569742..2569749 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2569760..2570049 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2569760 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2569764..2569783 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2570050..2571129 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2570050..2571129 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2571205..2572737 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2571205..2572737 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2572730..2573776 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2572730..2573776 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2573777..2574736 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2573777..2574736 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2574737..2574858 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2574831..2574834 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2574849..2574868 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2574860 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2574890..2576236 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2574890..2576236 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2576219 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2576272..2576487) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2576272..2576487) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2576427..2576433 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2576447..2576458 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2576451 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2576498..2576516) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2576505) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2576530..2576537 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2576532..2576537) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2576552..2576647 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2576552..2576571 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2576552 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2576610..2576614 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2576630..2576649 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2576649..2576798 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2576649 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2576718..2579123 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2576718..2579123 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2579116..2579547 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2579116..2579547 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2579547..2579888 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2579547..2579888 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2579779..2579879 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2579839 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2579881..2581362 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2579881..2581362 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2580614..2582482) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2581368..2581844 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2581368..2581844 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2581844..2582128 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2581844..2582128 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2582112..2582486 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2582112..2582486 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2582457 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2582525..2582905) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2582525..2582905) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2582527) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2582924..2583568) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2582924..2583568) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2583569..2583648) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2583649..2585958) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2583649..2585958) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2584643..2584650 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2584664..2584683 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2584679 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2585552..2586523 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2585552 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2585564..2585580 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2585973..2586140) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2585973..2586140) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2586128..2587026) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2586128..2587026) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2587027..2587140) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2587134..2587153) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587140) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587167..2587173) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2587211..2587351) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2587211..2587351) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2587240) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2587352..2587438) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2587422..2587441) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587438) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587455..2587461) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2587538..2587556) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587548) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587571..2587577) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2587573..2587698 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2587573..2587698 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2587726..2588155) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2587751..2587756 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2587768) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2587771..2587789 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2587773 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2587812..2588180 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2587812..2588180 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2588156..2589385) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2588156..2589385) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2588181..2589494 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2589420..2589439) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589439) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2589452 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2589454..2589461) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2589522..2590994) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2589522..2590994) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2589532) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2590875..2590879 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2590882 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2590992 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2591010..2591561) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2591010..2591561) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2591583..2591602) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2591596) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591615..2591622) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2591658..2592056) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2591658..2592056) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2592057..2592127) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2592128..2592376) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2592128..2592376) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2592399..2592418) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592410) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2592434..2592437) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2592449..2592670) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2592449..2592670) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2592476) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2592664 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2592688..2592707) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592694) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2592720..2592729) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2592730..2593839) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2592730..2593839) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2593491..2593498 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2593513..2593532 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2593522..2593916 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2593522 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2593887..2593906) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2593903) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2593905..2594345) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2593908..2593910 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2593918 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2593920..2593925) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2593926..2593945 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2593954..2594343 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2593954..2594343 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2594384..2594620) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2594384..2594620) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2594390) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2594640..2594659) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2594654) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2594656..2594796) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2594673..2594682) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2594797..2595327) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2594797..2595327) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2595347..2595366) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2595358) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2595360..2595446) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2595378..2595386) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2595441..2595460) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2595448) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2595474..2595483) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2595525..2596256) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2595525..2596256) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2595555) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2596271..2596290) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2596282) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2596305..2596312) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2596319..2596774) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2596319..2596774) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2596727..2596733 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2596748..2596766 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2596756..2599123 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2596756 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2596806..2600036) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2596806..2600036) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2600033..2604520) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2600033..2604520) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2603795..2603801 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2603816..2603834 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2603822..2604784 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2603822 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2604581..2605936) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2604581..2605936) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2604602) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2605951..2606190) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2605951..2606190) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2606260..2606553) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2606260..2606553) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2606270) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2606547 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2606554..2606632) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2606595..2606602 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2606612..2606631) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2606613 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2606617..2606634 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606632) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2606646..2606653) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2606691..2606696 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2606711..2606730 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2606723..2606829 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2606723 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2606898..2606904 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2606918..2606937 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2606921 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2607026..2607029 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2607038 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2607041..2607060) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2607045..2607064 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2607063) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2607074..2608342 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2607074..2608342 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2607075..2607082) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2608402..2608421 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2608407 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2608444..2609580 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2608444..2609580 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2609580 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2609629..2609637 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2609647 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2609649..2609667 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2609692..2610369 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2609692..2610369 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2610353 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2610413..2610622) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2610413..2610622) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2610425) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2610638..2617774) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2610638..2617774) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2617794..2618732) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2617794..2618732) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2618760..2620379) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2618760..2620379) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2620408..2621604) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2620408..2621604) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2621452..2621459 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2621474..2621493 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2621481 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2621630..2622415) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2621630..2622415) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2622416..2622525) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2622520..2622539) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2622525) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2622527..2622608) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2622553..2622560) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2622609..2623478) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2622609..2623478) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2623479..2623559) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2623543..2623562) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2623559) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2623576..2623583) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2623692..2624288) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2623692..2624288) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2624289..2624373) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2624324..2624331 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2624341 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2624346..2624365 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2624367..2624381) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2624373) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2624389..2624393) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2624389..2624991 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2624389..2624991 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2624977 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2625061..2626389) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2625061..2626389) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2625077) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2626443..2626462) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2626446) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2626477..2626484) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2626536..2628038) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2626536..2628038) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2626551) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2627603..2627617 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2627619 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2628039..2628113) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2628061..2628068 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2628079..2628098 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2628081..2628195 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2628081 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2628108..2628127) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2628118) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2628196..2628672 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2628196..2628672 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2628621 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2628703..2629359) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2628703..2629359) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2628731) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2629007..2629016 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2629030..2629049 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2629047 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2629049..2629495 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2629373) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2629375..2629386) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2629401..2629407) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2629452 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2629463..2629783) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2629463..2629783) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2629477) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2629497..2629707 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2629649..2629749 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2629709..2629818 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2629709 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2629775 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2629802..2629821) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2629807) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2629820..2630371 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2629836..2629843) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2629837..2629980) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2629837..2629980) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2630004..2630023) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2630025) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2630039..2630042) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2630153..2631373) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2630153..2631373) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2630181) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2631374..2631501) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2631501) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2631503..2631567) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2631503..2631521) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2631537..2631542) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2631558..2631577) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631566) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2631592..2631599) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2631641..2631648 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2631660..2631679 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2631660 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2631705..2632703 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2631705..2632703 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2631728..2631746) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631743) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2631763..2631768) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2632679 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2632742..2632882) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2632742..2632882) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2632754) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2632883..2633012) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2632993..2633012) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2633012) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2633014..2633261) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2633026..2633032) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2633069..2633076 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2633090..2633109 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2633098 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2633161..2634141 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2633161..2634141 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2633262) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2633266..2633277) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2633291..2633297) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2634109 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2634214) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2634215..2634838) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2634215..2634838) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2634862..2635380) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2634862..2635380) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2635427..2635446) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2635439) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2635441..2635549) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2635536..2635553) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635547) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2635568..2635575) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2635703) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2635718..2636080) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2635718..2636080) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2636111..2636130) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636121) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2636144..2636151) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2636159..2637013) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2636159..2637013) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2636729..2636748) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636737) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2636761..2636770) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2637035..2637054) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2637049) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2637069..2637072) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2637136..2638350) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2637136..2638350) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2637685..2637691 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2637706..2637724 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2637713 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2637717..2638486 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2638387..2638406) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2638392) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2638421..2638428) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2638443 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2638487..2638723) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2638487..2638723) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2638488..2638904 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2638505) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2638688..2638689) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2638693..2638697) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2638695) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2638738..2638757) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2638739) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2638771..2638778) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2638881..2638886 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2638900..2638919 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2638906 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2638986..2640053 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2638986..2640053 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2640037 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2640079..2640405) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2640079..2640405) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2640102) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2640437..2640456) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640454) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2640469..2640476) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2640489..2640493 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2640505..2640840 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2640505..2640840 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2640506..2640525 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2640511 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2640630) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2640818 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2640882..2642855) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2640882..2642855) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2640894) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2642870..2642888) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642893) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2642900..2642908) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2642963..2643892) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2642963..2643892) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2642976) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2643889..2644947) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2643889..2644947) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2644947..2646248) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2644947..2646248) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2646133..2646142 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2646157..2646176 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2646164 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2646249..2646330) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2646315..2646334) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2646330) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2646332..2646448) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2646349..2646356) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2646449..2647468) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2646449..2647468) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2647276..2647281 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2647297..2647315 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2647301 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2647491..2647509) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647498) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2647507..2647512 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2647525..2647530) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2647528..2647592 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2647528..2647546 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2647528 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2647565..2647574 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2647587..2647606 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2647594 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2647621..2648121 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2647621..2648121 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2648148..2648918) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2648148..2648918) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2648176) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2648947..2649381) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2648947..2649381) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2649405..2649680) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2649405..2649680) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2649700..2649719) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649725) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2649727..2650419) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2649733..2649740) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2649743..2649749 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2649764..2649775 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2649772 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2649795..2650427 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2649795..2650427 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2650388 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2650443..2651339) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2650443..2651339) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2650464) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2651340..2651474) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2651461..2651480) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2651474) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2651496..2651500) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2651514..2651520 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2651534..2651545 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2651546 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2651574..2652554 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2651574..2652554 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2651652) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2651666..2651685) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2651702..2651705) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2652546 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2652582..2653346) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2652582..2653346) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2652598) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2653360..2653378) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2653368) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2653394..2653399) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2653419..2653724) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2653419..2653724) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2653427) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2653738..2653757) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2653761) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2653771..2653779) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2653789..2655177) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2653789..2655177) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2655197..2656018) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2655197..2656018) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2656036..2656884) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2656036..2656884) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2656403..2656408 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2656424..2656442 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2656438 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2656895..2656914) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2656910) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2656922..2657269) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2656922..2657269) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2657282..2657301) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2657301) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2657315..2657321) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2657366..2658706) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2657366..2658706) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2657394) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2658450) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2658763..2658769 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2658783..2658802 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2658785..2658803) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2658791 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2658792..2658880 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2658802) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2658819..2658824) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2658881..2660476 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2658881..2660476 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2660621..2661970 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2660621..2661970 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2661976..2663268 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2661976..2663268 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2663281..2664765 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2663281..2664765 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2664765..2665109 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2664765..2665109 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2664831..2664834 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2664852..2664871 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664864 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2665084 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2665125..2665512) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2665472..2665481 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2665494..2665513 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2665497 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2665533..2665664) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2665533..2665664 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2665533..2665664 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2665533..2665664) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2665665..2665733 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2665700 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2665870..2666391) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2665870..2666391) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2666382..2668619) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2666382..2668619) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2668620..2669453) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2668620..2669453) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2669450..2670067) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2669450..2670067) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2669559) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2670064..2671056) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2670064..2671056) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2671057..2671143) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2671121..2671140) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2671143) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2671154..2671159) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2671285..2672535) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2671285..2672535) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2672552..2673790) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2672552..2673790) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2674013..2674150 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2674013..2674150 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2674172..2674175 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2674190..2674209 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2674191 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2674232..2675098 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2674232..2675098 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2675101 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2675132..2676235) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2675132..2676235) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2675147) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2676236..2677169) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2676273..2676280 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2676294..2676313 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2676304 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2676355..2676361 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2676372 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2676376..2676395 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2676417..2677145 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2676417..2677145 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2677170..2678024) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2677170..2678024) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2677357..2677376) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2677369) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2677527..2677627) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2677567) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2678038..2678940) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2678038..2678940) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2678944..2679822) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2678944..2679822) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2679880..2681148) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2679880..2681148) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2681039..2681139 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2681099 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2681219) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2681229..2682215) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2681229..2682215) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2682162 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2682165..2682169 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2682258..2682277) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682271) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2682292..2682299) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2682429) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2682431..2682805) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2682431..2682805) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2682869) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2682876..2682887) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2682901..2682907) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2682908..2684026) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2682908..2684026) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2684051..2684070) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684057) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2684059..2684669) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2684084..2684090) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2684123..2684132 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2684146..2684165 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2684150 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2684163..2684178) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684167) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2684185..2684189) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2684185..2684331 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2684185..2684331 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2684331..2684606 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2684331..2684606 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2684475) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2684491..2684505) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2684514..2684518) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2684586 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2684670..2685053) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2684670..2685053) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2685054..2685163) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2685164..2685442) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2685164..2685442) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2685440..2685459) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2685464) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2685474..2685481) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2685605..2685711) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2685648) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2685712..2687109) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2685712..2687109) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2686907 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2687130..2687573) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2687130..2687573) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2687563..2688783) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2687563..2688783) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2688783..2690096) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2688783..2690096) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2690114..2690899) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2690114..2690899) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2690943..2690962) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2690944) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2690976..2690983) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2691000..2691019) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2691009) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2691011..2691092) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2691035..2691039) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2691056..2691303) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2691056..2691303) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2691093..2691230) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2691093..2691230) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2691231..2691315) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2691299..2691318) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2691315) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2691317..2691423) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2691334..2691337) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2691424..2691801) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2691424..2691801) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2691818..2691829) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2691824) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2691843..2691849) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2691886..2692710) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2691886..2692710) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2691894) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2692043) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2692070..2692075 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2692091..2692109 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2692093 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2692724..2693392) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2692724..2693392) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2693385..2694410) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2693385..2694410) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2694411..2694515) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2694516..2694622) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2694516..2694622) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2694585 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2694649..2694668) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2694661) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2694663..2694736) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2694684..2694691) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2694737..2695081) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2694737..2695081) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2695082..2695187) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2695188..2695508) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2695188..2695508) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2695510..2695950) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2695510..2695950) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2695950..2696186) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2695950..2696186) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2695962) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2696201) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2696206..2696217) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2696232..2696238) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2696242..2696625) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2696242..2696625) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2696652..2696671) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2696663) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2696684..2696691) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2696692..2697048) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2696692..2697048) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2697071..2697090) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2697081) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2697104..2697109) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2697159..2698943) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2697159..2698943) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2697169) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2698958..2700133) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2698958..2700133) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2700144..2702513) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2700144..2702513) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2701932..2701937 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2701952..2701970 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2701955 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2702581..2702600) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2702584) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2702592..2702858) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2702614..2702621) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2702639..2702645 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2702660..2702671 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2702682 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2702688..2702834 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2702688..2702834 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2702835..2703861 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2702859..2703767) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2702859..2703767) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2703768..2704290) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2703862..2704107 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2703862..2704107 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2704120..2704452 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2704120..2704452 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2704273..2704292) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2704290) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2704306..2704315) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2704441 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2704513..2704520 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2704534..2704553 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2704545 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2704611..2705078 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2704611..2705078 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2705075..2706700 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2705075..2706700 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2706685 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2706736..2707119) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2706736..2707119) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2707138..2707527) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2707138..2707527) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2707549..2707878) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2707549..2707878) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2707913..2707932) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2707920..2707927 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2707927) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2707942..2707961 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2707946..2707953) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2707952 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2708012..2708899 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2708012..2708899 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2708919..2709206) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2708919..2709206) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2708931) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2709231..2710058) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2709231..2710058) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2709247) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2710059..2710196) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2710181..2710200) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710196) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2710216..2710219) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2710276..2710713) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2710276..2710713) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2710737..2710755) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2710743) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2710771..2710776) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2710823..2712331) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2710823..2712331) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2710844) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2712322..2712618) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2712322..2712618) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2712641..2712660) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712657) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712675..2712678) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2712695..2712700 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2712712..2712731 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2712712 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2712752..2713594 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2712752..2713594 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2713124..2713130 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2713145..2713156 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2713153 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2713621..2713628 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2713637 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2713640..2713659 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2713684..2714145 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2713684..2714145 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2714121 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2714189..2715565) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2714189..2715565) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2714197) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2715566..2715737) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2715718..2715737) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2715737) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2715748..2715755) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2715798..2715817) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2715808..2715827 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2715810 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2715816) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2715818..2716881) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2715832..2715839) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2715843..2716520 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2715843..2716520 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2716517..2717872 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2716517..2717872 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2716971..2717899) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2717840 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2717900..2718064) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2717900..2718064) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2718088..2718095 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2718109..2718128 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2718113..2718132) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2718119..2718231 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2718119 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2718126) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2718128..2718406) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2718146..2718153) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2718232..2719107 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2718232..2719107 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2718396..2718415) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718406) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2718408..2718949) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2718429..2718436) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2718941..2718959) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718949) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2718951..2719080) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2718972..2718979) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2719082 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2719125) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2719143..2720531) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2719143..2720531) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2720555) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2720560..2720578) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2720589..2720597) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2720598..2720783) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2720598..2720783) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2720787 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2720827..2720846) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2720836..2720842 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2720841) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2720856..2720867 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2720859 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2720862..2720865) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2720901..2722349 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2720901..2722349 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2721897..2724540) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2722318..2723415 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2722318..2723415 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2723412..2724533 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2723412..2724533 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2724541..2725176) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2724541..2725176) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2725154..2726236) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2725154..2726236) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2726233..2726958) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2726233..2726958) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2726992..2727864) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2726992..2727864) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2727883..2727902) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727903) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727917..2727920) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2727965..2728642) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2727965..2728642) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2727981) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2728669..2729049) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2728669..2729049) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2729072..2729091) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729092) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2729106..2729109) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2729211..2730479) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2729211..2730479) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2729224) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2730513..2730532) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730524) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2730547..2730554) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2730650) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2730656..2731237) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2730656..2731237) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2731260..2732588) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2731260..2732588) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2732588..2733649) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2732588..2733649) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2733612..2734556) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2733612..2734556) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2734557..2734826) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2734665..2734795) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2734665..2734795) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2734803..2734822) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2734826) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2734828..2735755) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2734838..2734845) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2734888..2734895 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2734910..2734929 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2734914 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2734954..2735745 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2734954..2735745 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2735616 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2735726 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2735783..2736661) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2735783..2736661) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2735800) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2736685..2736703) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736704) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2736717..2736723) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2736733..2738475) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2736733..2738475) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2738472..2739185) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2738472..2739185) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2739216..2739235) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2739234) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2739338..2739577) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2739338..2739577) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2739345) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2739573..2739591) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2739581..2740111) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2739581..2740111) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2739582) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739606..2739612) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2740114..2740133) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740121) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2740126..2740464 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2740126..2740464 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2740148..2740155) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2740164..2740183) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740176) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2740198..2740204) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2740210..2740310 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2740270 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2740438..2740538 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2740498..2740584 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2740498 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2740585..2741742 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2740585..2741742 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2741728 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2741803..2742213 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2741803..2742213 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2742212 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2742247..2743476) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2742247..2743476) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2742264) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2743469..2744158) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2743469..2744158) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2744142..2745335) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2744142..2745335) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2745379..2745398) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2745392) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2745413..2745420) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2745506..2746315) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2745506..2746315) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2745523) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2745662..2745671 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2745684..2745703 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2745688 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2746331..2747341) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2746331..2747341) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2747341..2748495) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2747341..2748495) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2748428..2748447) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2748445) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2748459..2748466) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2748507..2748514 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748529..2748548 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748538 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2748593..2749540 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2748593..2749540 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2749516 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2749560 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2749714 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2749775..2751184) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2749775..2751184) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2749790) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2750602..2750606 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2750624..2750640 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750631 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2750638..2751605 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2751286) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2751288..2751467) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2751288..2751467) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2751497..2751514) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751508) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2751529..2751536) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2751562 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2751584..2751724) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2751584..2751724) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2751594) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2751752) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2751754..2752342) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2751757..2751768) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2751782..2751788) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2751814..2751821 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2751835 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2751837..2751856 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2751891..2752373 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2751891..2752373 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2752387..2752394 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752408..2752427 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2752420 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2752473..2754326 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2752473..2754326 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2754312 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2754354..2755280) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2754354..2755280) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2754366) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2755292..2755311) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755313) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2755327..2755330) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2755349..2755368 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2755358 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2755391..2756173 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2755391..2756173 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2756145..2756837 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2756145..2756837 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2756829 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2756868..2757698) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2756868..2757698) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2756874) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2757561..2757565 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757581..2757585 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2757590 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2757700 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2757728..2757747) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757746) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2757762..2757769) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2757854..2757860 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2757874 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2757875..2757893 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2757921..2758406 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2757921..2758406 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2758405 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2758450..2760462) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2758450..2760462) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2758458) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2760128..2760132) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2760130) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2760463..2760614) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2760591..2760609) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2760614) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2760717..2762432) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2760717..2762432) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2760724) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2762458..2764275) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2762458..2764275) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2764317..2764336) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2764326..2764333 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2764336) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2764339 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2764346..2764365 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2764349..2764356) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2764446..2766770) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2764446..2766770) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2764464) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2766790..2766797 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2766812..2766831 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2766813..2766828) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2766816 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2766818) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2766863..2766882) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766872) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2766898..2766904) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2766908..2766927) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766928) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2766941..2766949) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2766955) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2766968..2767576) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2766968..2767576) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2767615..2767634) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2767632) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2767650..2767654) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2767763..2768179) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2767763..2768179) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2767773) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2768184..2768852) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2768184..2768852) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2768904..2768923) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2768919) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2768930) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2768937..2768942) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2768972..2771080) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2768972..2771080) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2771072..2771173) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2771167..2771186) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771173) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2771202..2771209) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2771240..2773648) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2771240..2773648) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2771262) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2771328) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2773649..2773731) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2773732..2773941) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2773732..2773941) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2773965..2773984) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2773986) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2773997..2774003) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2774015..2774320) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2774015..2774320) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2774284..2774303 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2774295 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2774334..2774353) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2774360) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2774367..2774373) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2774412..2774418 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774433..2774451 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2774441 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2774448..2775524 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2774448..2775524 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2775511 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2775561..2776196) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2775561..2776196) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2775574) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2776197..2776294) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2776274..2776293) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2776294) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2776307..2776313) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2776356..2778251) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2776356..2778251) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2778302..2778313) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2778302) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2778328..2778334) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2778401) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2778414..2778815) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2778414..2778815) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2778812..2779171) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2778812..2779171) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2779168..2779740) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2779168..2779740) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2779778..2779797) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2779783) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2779811..2779818) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2779851..2780645) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2779851..2780645) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2780666..2780684) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780678) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2780699..2780705) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2780711..2780730) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780722) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2780724..2780789) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2780744..2780751) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2780831..2781190) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2780831..2781190) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2780834) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2781174..2781182) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781184) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2781197..2781202) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2781242..2781261) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781250) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2781252..2781316) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2781274..2781278) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2781316) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2781317..2781336) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2781351..2781358) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2781367..2781837) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2781367..2781837) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2781664..2781764 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2781724 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2781834 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2781882..2781901) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2781888) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2781890..2781981) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2781917..2781920) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2781982..2784321) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2781982..2784321) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2783082..2783085 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2783101..2783104 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2783110 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2784340..2785080) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2784340..2785080) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2784736..2784754) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2784748) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2784769..2784775) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2785108..2785126) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2785122) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2785210) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2785212..2785442) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2785212..2785442) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2785472..2785491) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2785493) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2785506..2785509) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2785531..2785537 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2785551..2785562 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2785552 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2785591..2786361 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2785591..2786361 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2785613..2785621 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2785632..2785650 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2785662 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2786401..2786634) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2786401..2786634) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2786725..2786732 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2786740 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2786744..2786763 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2786786..2787193 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2786786..2787193 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2787223..2787642 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2787223..2787642 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2787680..2787687 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2787701..2787720 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2787708 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2787734..2788060 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2787734..2788060 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2788061..2788145 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2788116..2788123 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2788136..2788154 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2788147 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2788185..2789885 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2788185..2789885 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2788901..2789894) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2789863 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2789925..2790605) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2789925..2790605) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2789939) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2790299..2790305 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2790320..2790338 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2790325..2793076 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2790325 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2790622..2791542) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2790622..2791542) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2791554..2792207) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2791554..2792207) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2792224..2793369) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2792224..2793369) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2793370..2793437) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2793437) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2793438..2793457) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2793468..2793472 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2793472..2793475) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2793488..2793506 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2793493 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2793588..2793592 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2793608..2793627 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2793611 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2793653..2794186 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2793653..2794186 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2793853..>2794252) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2794175 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2794252,2794259) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2794253..2794258 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2794259..2794334 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2794259..2794325) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2794330..2795019) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2794330..2795019) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2794370) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2794962..2794970 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2794984..2795003 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2794998 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2795037..2795948) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2795037..2795948) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2795968..2796621) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2795968..2796621) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2796644..2797786) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2796644..2797786) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2797830..2797849) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2797845) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2797864..2797867) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2797983..2797990 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2798003..2798022 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2798014 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2798050..2798607 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2798050..2798607 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2798608..2799372 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2798625..2799260) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2798625..2799260) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2798638) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2799301..2799319) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2799307) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2799335..2799341) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2799346..2799353 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2799365..2799384 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2799374 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2799410..2800024 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2799410..2800024 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2800010 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2800078..2800081 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2800096..2800115 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2800104 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2800156..2800854 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2800156..2800854 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2800827 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2800890..2802707) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2800890..2802707) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2800909) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2801080) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2802749..2802768) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2802753..2802772 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2802758 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2802762) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2802827..2803294 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2802827..2803294 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2803291 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2803339..2804631) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2803339..2804631) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2803349) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2804661..2806196) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2804661..2806196) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2806189..2806950) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2806189..2806950) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2806981..2808165) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2806981..2808165) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2808166..2808406) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2808406) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2808408..2808481) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2808420..2808439) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2808455..2808459) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2808482..2809489) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2808482..2809489) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2809408..2809411 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2809428..2809430 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2809430 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2809536..2810558) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2809536..2810558) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2809552) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2809580..2809581) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2810559..2810670) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2810596 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2810651..2810670) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810670) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2810672..2810782) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2810684..2810691) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2810765..2810784) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2810780) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2810797..2810806) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2810856..2812250) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2810856..2812250) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2810870) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2812349..2812368) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2812363) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2812383..2812390) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2812390..2812397 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2812411..2812430 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2812417 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2812454..2813542 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2812454..2813542 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2813522 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2813591..2814601) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2813591..2814601) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2813598) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2814602..2814679) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2814669..2814688) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814679) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2814702..2814709) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2814758..2815636) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2814758..2815636) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2815294..2815300 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2815315..2815326 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2815326 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2815670..2815677 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2815683..2815702) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2815688) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2815691..2815710 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2815693 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2815716..2815720) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2815736..2816653 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2815736..2816653 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2816642 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2816694..2818037) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2816694..2818037) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2818106..2818341) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2818106..2818341) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2818240) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2818342..2818438) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2818439..2819473) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2818439..2819473) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2819495..2819513) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2819501) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2819526..2819533) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2819581..2820303) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2819581..2820303) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2819597) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2820303..2821742) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2820303..2821742) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2821290..2821293 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2821310 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2821311..2821315 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2821464 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2821618 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2821619..2821620 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2821769..2822485) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2821769..2822485) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2822389..2822396 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2822410..2822412 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2822410 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2822483 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2822486..2822552) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2822549..2822568) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2822552) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2822583..2822590) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2822660..2823262) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2822660..2823262) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2823279..2824394) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2823279..2824394) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2824398..2825135) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2824398..2825135) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2824424..2824443) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2824438) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2824455..2824462) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2825136..2826041) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2825136..2826041) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2826061..2826079) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2826072) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2826095..2826098) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2826250..2826257 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2826268..2826287 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2826275 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2826325..2827134 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2826325..2827134 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2827170..2828381 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2827170..2828381 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2828368 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2828435..2829724) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2828435..2829724) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2829804..2831867) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2829804..2831867) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2831886..2832737) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2831886..2832737) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2832741..2833997) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2832741..2833997) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2834037..2835302) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2834037..2835302) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2835334..2835353) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835356) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2835368..2835375) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2835443..2836435) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2835443..2836435) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2835477) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2836565..2836614) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2836588) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2836615..2837274) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2836615..2837274) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2837275..2837380) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2837372..2837391) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837381) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2837406..2837409) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2837433..2837440 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2837455..2837474 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2837455 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2837458..2837563 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2837464..2837481) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837468) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2837489..2837495) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2837564..2839255 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2837564..2839255 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2839240 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2839282..2840592) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2839282..2840592) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2839285..2840355 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2839294) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2840412..2840431 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2840412..2840670 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2840412 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2840606..2840625) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2840621) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2840640..2840643) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2840671..2840889 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2840671..2840889 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2840868 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2840896,2840903) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2840897..2840902 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2840934..2840937 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2840943 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2840954..2840972 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2840988..2842457 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2840988..2842457 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2842434 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2842460..2842651 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2842460..2842651 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2842630 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2842678..2843163) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2842678..2843163) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2843186..2843497) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2843186..2843497) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2843549..2843641) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2843549..2843641) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2843681..2843700) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843698) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843714..2843721) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2843772..2844455) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2843772..2844455) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2843790) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2844471..2845826) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2844471..2845826) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2845838..2845853) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845854) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2845865..2845874) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2846128..2846135 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2846149..2846168 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2846152 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2846174..2846364 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2846365..2847786 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2846365..2847786 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2847780 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2847860..2849410 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2847860..2849410 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2849454..2849460 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849474..2849485 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849474 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2849518..2851080 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2849518..2851080 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2851058 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2851070..2851759 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2851070..2851759 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2851109..2851116 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2851130..2851149 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2851139 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2851740 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2851838) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2851841..2852176 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2851841..2852176 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2852176..2852496 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2852176..2852496 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2852497..2852687 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2852532..2853044) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2852532..2853044) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2852664 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2853080..2853091) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2853086) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2853106..2853112) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2853159..2853295) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2853202) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2853296..2854639) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2853296..2854639) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2854668..2854687) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2854676) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2854700..2854709) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2854701..2854706 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2854722..2854740 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2854725 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2854934..2854943 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2854952 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2854957..2854976 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2854995..2855957 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2854995..2855957 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2855958..2856211 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2856238) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2856242..2856317) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2856242..2856317) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2856344..2856363) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2856365) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2856379..2856382) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2856448..2856454 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2856464..2856539 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2856464 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2856469..2856488 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2856516..2856523 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2856537..2856556 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2856541 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2856587..2857180 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2856587..2857180 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2857169 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2857214..2857612 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2857226..2857906) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2857226..2857906) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2857250) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2857903..2859588) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2857903..2859588) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2859581..2861854) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2859581..2861854) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2861832..2862716) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2861832..2862716) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2862722..2863558) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2862722..2863558) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2863559..2864866) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2863559..2864866) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2863924..2863933 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2863946..2863965 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2863950 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2864906..2866159) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2864906..2866159) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2866160..2866254) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2866255..2868024) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2866255..2868024) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2867945..2867950 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2867966..2867984 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2867976 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2868062..2868081) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2868075) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2868094..2868101) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2868137..2869087) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2868137..2869087) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2869102..2869120) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2869115) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2869132..2869140) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2869221) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2869293..2869868) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2869293..2869868) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2869305) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2869911..2869930) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2869917..2869924 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2869927) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2869934 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2869937..2869956 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2869945..2869952) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2869985..2870305 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2869985..2870305 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2870286 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2870332) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2870332..2871924) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2870332..2871924) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2871943..2872536) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2871943..2872536) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2872578..2872597) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872591) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2872612..2872616) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2872662..2872667 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2872683..2872701 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2872684 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2872857..2872864 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2872878..2872897 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2872882 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2872919..2873896 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2872919..2873896 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2873868 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2873934..2875874) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2873934..2875874) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2873958) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(2875849..2876628) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(2875849..2876628) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(2876629..2876710) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(2876711..2877781) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(2876711..2877781) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(2877775..2878488) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(2877775..2878488) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(2878534..2878553) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2878546) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2878548..2878809) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(2878566..2878569) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2878569..2878576 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2878587..2878606 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2878592 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2878635..2878844 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 2878635..2878844 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 2878822 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2878854) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2878880..2879644) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(2878880..2879644) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(2878902) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2879645..2879902) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(2879645..2879902) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(2879926..2880876) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(2879926..2880876) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(2880899..2881852) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(2880899..2881852) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(2881854..2882741) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(2881854..2882741) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(2882766..2883242) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(2882766..2883242) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(2883262..2883281) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2883276) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2883297..2883301) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2883320..2883339) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2883333) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2883354..2883357) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2883409..2883559) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(2883452) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(2883560..2884510) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(2883560..2884510) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(2884511..2884598) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(2884587..2884606) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2884598) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2884600..2884691) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(2884621..2884624) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2884639..2884645 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2884659..2884677 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2884673 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 2884674..2888060 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(2884716..2886137) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(2884716..2886137) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(2884736) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(2884860) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 2885764..2885768 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2885774 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2886053..2886057 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2886060 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2886138..2886335) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 2886258 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2886323..2886342) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(2886335) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(2886354..2886361) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(2886518..2887972) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(2886518..2887972) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(2886538) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(2887973..2888097) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 2888018 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2888098..2889867) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(2888098..2889867) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(2889868..2889942) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(2889931..2889950) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2889942) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(2890032..2890391) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(2890032..2890391) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(2890052) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2890406..2892316) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(2890406..2892316) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(2892318..2892860) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /modified_by="User" /translation="MVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGKNKE SIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKKTDI YTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDEEKA KNKVEKLINSITFLIDKKEK*" /label="PG10_pseudo_BSU_34850" gene complement(2892318..2892860) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /modified_by="User" /label="PG10_pseudo_BSU_34850" N_region 2892919..2893968 /comment="Inserted sequence is a combination of three independent chromosomal regions. First the arabinose inducible mtlA promoter, second a copy of the original comK gene as well as third a copy of the original comS gene." /modified_by="User" /label="IIG_Bs27_024" promotor_-35 2892979..2892986 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2893000..2893019 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2893005 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" CDS 2893079..2893657 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 2893079..2893657 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" CDS 2893706..2893846 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 2893706..2893846 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" S_feature complement(<2893969..2894010) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" CDS complement(2894036..2894665) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(2894036..2894665) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(2894055) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(2894662..2895420) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(2894662..2895420) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(2895417..2896154) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(2895417..2896154) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(2896151..2896789) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(2896151..2896789) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 2896647..2896747 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2896707 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2896790..2897374) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(2896790..2897374) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(2897371..2898654) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(2897371..2898654) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(2898651..2899292) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(2898651..2899292) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(2899285..2900460) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(2899285..2900460) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(2900461..2900538) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 2900504..2900510 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2900522..2900541 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2900522..2900541) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2900535 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2900538) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2900554..2900561) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2900670..2900689 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2900677 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 2900711..2901463 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 2900711..2901463 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 2901464..2901702 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(2901485..2901496) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2901491) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2901511..2901517) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2901703..2902368 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 2901703..2902368 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 2902339 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2902388..2902906) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(2902388..2902906) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(2902422) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2902910..2903560) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(2902910..2903560) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(2903557..2904495) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(2903557..2904495) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(2904519..2905328) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(2904519..2905328) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(2905342..2906274) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(2905342..2906274) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(2906316..2906335) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906322) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2906351..2906356) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2906391..2906398 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2906410 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2906413..2906430 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2906456..2907646 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 2906456..2907646 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 2907444..2907450 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2907465 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2907466..2907484 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2907643..2908371 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 2907643..2908371 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 2908389..2909120 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 2908389..2909120 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(2909140..2913009) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(2909140..2913009) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(2909262) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2913029..2913040) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2913036) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2913055..2913061) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2913099..2913105 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2913119..2913138 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2913124 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 2913174..2913647 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 2913174..2913647 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 2913648..2913755 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(2913688..2914905) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(2913688..2914905) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(2913701) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2913727..2913732 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2913747..2913758 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2913757..2914042 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 2913757 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 2913999 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2914921..2915667) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(2914921..2915667) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(2915668..2915854) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(2915840..2915859) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915854) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2915873..2915880) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2915988..2915995 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2916010..2916029 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2916022 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 2916023..2916092 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 2916093..2916602 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 2916093..2916602 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(2916498..2917836) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(2916539) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2916623..2917834 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 2916623..2917834 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 2917832 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(2917862..2918221) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(2917862..2918221) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 2917877..2918593 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(2917881) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2918223..2918420) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(2918223..2918420) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(2918425..2919522) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(2918425..2919522) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(2919547..2919873) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(2919547..2919873) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(2919926..2919941) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2919941) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2919943..2920433) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(2919953..2919962) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2920021..2920024 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2920039..2920058 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2920049 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 2920091..2920321 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 2920091..2920321 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(2920424..2920443) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(2920434) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(2920459..2920463) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(2920520..2921002) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(2920520..2921002) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 2920528 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(2920543) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2920675) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2920683..2920686) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2920763..2920767) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2920763) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2920783..2920786) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2921003..2921136) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(2921164..2924037) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(2921164..2924037) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(2921181) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2924045..2926030) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(2924045..2926030) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(2926064..2926083) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2926076) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2926078..2926163) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(2926095..2926102) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2926208) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(2926216..2926446) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(2926216..2926446) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(2926473..2926492) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(2926483) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(2926485..2926549) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(2926506..2926513) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(2926526..2926544) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2926547) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2926559..2926565) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2926615) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2926641..2926741) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2926681) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2926763..2926770 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2926784..2926803 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2926801 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2926893..2929388 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 2926893..2929388 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 2929403..2929407 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2929421 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 2929464..2930033 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 2929464..2930033 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 2930064..2931398 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 2930064..2931398 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 2931379 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(2931446..2932639) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(2931446..2932639) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(2931455) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(2931520) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2932640..2932717) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(2932643) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2932718..2933056) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(2932718..2933056) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(2933031..2933147) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(2933031..2933147) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(2933148..2933237) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(2933219..2933237) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2933237) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2933239..2933319) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(2933251..2933256) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2933305..2933323) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2933319) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2933337..2933344) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2933456..2934898) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(2933456..2934898) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(2933545) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2934944..2934955) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2934955) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2934970..2934976) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2935038..2935928) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(2935038..2935928) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(2935055) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(2935921..2936607) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(2935921..2936607) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(2936608..2936740) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(2936730..2936749) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2936740) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2936764..2936767) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2936841..2937179) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(2936841..2937179) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(2936842) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2937206..2937225) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(2937219) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(2937228..2938112) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(2937228..2938112) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(2937239..2937246) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(2938100..2938119) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(2938121) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(2938134..2938141) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(2939269..2939340), complement(2938239..2939267)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(2938239..2939340) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(2938255) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2939341..2939409) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(2939410..2941935) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(2939410..2941935) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(2941936..2942016) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(2942006..2942025) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2942016) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2942103..2942672) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(2942103..2942672) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(2942111) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 2942639..2942645 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2942658..2942677 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2942665 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2942699..2942717) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2942707) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2942709..>2942810) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(2942729..2942737) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2942810..2942811 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(2942814..2943296) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(2942814..2943296) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(2943312..2943578) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(2943312..2943578) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(2943579..2943658) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(2943659..2944078) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(2943659..2944078) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(2944117..2944135) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944128) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2944149..2944156) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2944152..2944874) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(2944152..2944874) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(2944838..2945134) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(2944838..2945134) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(2945160..2945179) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945173) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2945190..2945197) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2945194..2946585) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(2945194..2946585) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(2946599..2946618) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2946614) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2946632..2946639) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2946691..2947536) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(2946691..2947536) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(2946702) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2946953..2946960 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2946974..2946993 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2946984..2948716 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 2946984 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2947563..2947582) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947582) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2947597..2947600) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2947634..2948323) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(2947634..2948323) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(2947648) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(2948324..2948405) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(2948406..2949563) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(2948406..2949563) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(2949564..2949691) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 2949611..2949614 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2949629..2949648 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2949640..2949726 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 2949640 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2949685..2949704) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2949691) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2949708..2949716 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2949715..2949722) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2949728 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2949730..2949738 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2949780..2950433 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 2949780..2950433 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(2950136..2950728) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 2950433..2951608 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 2950433..2951608 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(2950724..2950742) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950733) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2950756..2950762) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2951580 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2951681..2952757) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(2951681..2952757) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(2951697) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2951743..2951752 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2951766..2951785 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2951774..2953007 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 2951774 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2952758..2952840) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(2952828..2952847) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952840) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2952859..2952865) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2952902..2954095) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(2952902..2954095) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(2952932) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(2954124..2954882) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(2954124..2954882) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(2954906..2955586) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(2954906..2955586) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(2955615..2957081) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(2955615..2957081) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(2957082..2957165) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(2957166..2958551) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(2957166..2958551) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(2958613..2959782) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(2958613..2959782) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(2959779..2961230) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(2959779..2961230) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(2961286..2961435) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(2961286..2961435) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(2961380..2961919) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(2961380..2961919) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(2961975..2961992) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2961979) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2962146..2963636) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(2962146..2963636) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(2962168) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2963675..2965792) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(2963675..2965792) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(2965816..2966124) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(2965816..2966124) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 2966030 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 2966120..2966124 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2966133..2966147 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2966134..2966152) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2966140 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966166..2966173) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2966169) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2966190..2966198 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2966212..2966225 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2966230 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 2966308..2967228 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 2966308..2967228 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 2967218 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2967268..2968410) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(2967268..2968410) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(2967292) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2968449..2968468) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968463) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2968483..2968486) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2968539..2968543 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2968559..2968578 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2968560..2968655 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 2968561 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 2968656..2969534 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 2968656..2969534 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 2969535..2970626 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(2969604..2969959) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 2969868..2970086 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 2969868..2970086 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(2969960..2970043) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(2969960..2970043) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(2970044..2970235) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(2970236..2972938) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(2970236..2972938) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(2972939..2973061) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 2972960..2972966 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2972981..2972999 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2972986..2975818 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 2972986 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2973062..2974402) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(2973062..2974402) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(2974443..2974649) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(2974443..2974649) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(2974650..2975523) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(2975517..2975536) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2975523) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2975525..2975764) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(2975549..2975555) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2975746..2975764) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(2975764) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(2975778..2975785) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 2975787..2975794 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2975806..2975825 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2975820..2975950 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 2975820 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 2975892..2975992 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2975952 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2975956..2976552 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 2975956..2976552 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 2976150 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2976591..2978174) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(2976591..2978174) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 2976634 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(2978194..2979021) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(2978194..2979021) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(2979022..2979086) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(2979082..2979101) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2979086) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2979088..2979185) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(2979117..2979120) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2979186..2981426) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(2979186..2981426) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(2981426..2983447) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(2981426..2983447) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 2982189..2982198 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2982211..2982226 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2982222 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2983448..2983607) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(2983608..2983997) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(2983608..2983997) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(2983998..2984132) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(2984116..2984135) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984132) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2984146..2984153) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2984287..2984293 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2984304..2984396 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 2984304 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2984305..2984324 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2984397..2985167 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 2984397..2985167 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(2984524..2984872) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(2984876..2984887) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984880) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2984902..2984908) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2985192 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 2985200..2986345 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 2985200..2986345 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 2986333 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 2986387..2986394 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986409..2986428 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986419 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 2986465..2987793 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 2986465..2987793 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 2987788 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2987849) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 2987873..2987874 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 2987897 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2987950..2989191) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(2987950..2989191) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(2987969) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2989213..2989231) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2989235) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2989244..2989251) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2989332..2989499) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(2989332..2989499) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(2989359) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(2989514..2990656) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(2989514..2990656) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(2990675..2991124) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(2990675..2991124) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 2990818..2990824 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 2990832 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 2990838..2990856 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 2990845..2993054 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(2991139..2992320) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(2991139..2992320) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 2993034..2993041 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2993056 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2993057..2993076 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2993077) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2993082..2993096) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2993104..2993108) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2993104..2994084 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 2993104..2994084 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 2993933..2993940 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2993954..2993973 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2993969 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 2994086..2994967 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 2994086..2994967 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 2994964..2995359 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 2994964..2995359 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 2995375..2996856 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 2995375..2996856 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 2996858..2997826 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 2996858..2997826 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 2997838..2998755 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 2997838..2998755 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 2998764..2998770 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998785..2998803 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998787 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 2998837..2999373 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 2998837..2999373 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 2999356 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 2999401..2999511 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 2999480..2999486 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2999501..2999512 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2999513 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 2999529..2999825 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 2999529..2999825 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 2999826..3000478 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(2999865..3000392) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(2999865..3000392) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(2999875) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3000412..3000431) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3000425) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3000436 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3000445..3000452) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3000491) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3000492..3001259) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3000492..3001259) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3001321..3003033) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3001321..3003033) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3001932..3001941 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3001955..3001974 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3001955 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3003087..3003106) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3003092) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3003112..3003119 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3003121..3003125) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003133..3003152 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003143 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3003191..3004099 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3003191..3004099 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3004167..3004175 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3004177..3004309 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3004177 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3004189..3004208 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3004310..3005638 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3004310..3005638 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3005629 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3005695..3006372) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3005695..3006372) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3005705) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3006432..3007574) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3006432..3007574) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3007611..3007630) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3007619) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3007621..3007701) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3007644..3007652) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3007702..3008790) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3007702..3008790) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3008791..3008904) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3008846..3008855 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3008868..3008887 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3008881 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3008904) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3008908..3008922) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3008931..3008935) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3008931..3009518 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3008931..3009518 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3009019..3009498 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3009019..3009498 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3009402..3009599) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3009435 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3009445) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3009504 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3009583 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3009598..3009617) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009604) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3009626..3009633 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3009630..3009639) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3009648..3009667 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3009654 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3009692..3010309 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3009692..3010309 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3010310..3010410 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3010367 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3010436..3010445 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010457..3010472 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010458 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3010487..3010822 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3010487..3010822 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3010778..3010796) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3010787) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3010811..3010816) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3010821 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3010827..3012404) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3010827..3012404) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3010866..3012577 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3012555..3012562 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3012573..3012592 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3012579 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3012618..3013094 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3012618..3013094 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3013108..3013701 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3013108..3013701 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3013698..3014234 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3013698..3014234 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3014215 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3014261..3014482) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3014261..3014482) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3014429 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3014436..3014437 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3014479..3015024) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3014479..3015024) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3015041..3015048 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3015063..3015082 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3015067 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3015147..3016028 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3015147..3016028 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3016113..3016829) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3016113..3016829) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3016133) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3016839..3017303) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3016839..3017303) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3017293..3019101) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3017293..3019101) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3019120..3019380) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3019120..3019380) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3019390..3019812) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3019390..3019812) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3019813..3019895) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3019887..3019906) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3019895) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3019919..3019926) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3020029..3020154) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3020029..3020154) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3020072..3020203) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3020115) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3020204..3020989) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3020204..3020989) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3020990..3021105) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3021098..3021117) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3021105) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3021131..3021138) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3021181..3022503) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3021181..3022503) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3021193) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3022537) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3022539..3022664) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3022539..3022557) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3022573..3022578) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3022644..3022663) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3022664) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3022698..3023462) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3022698..3023462) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3023481) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3023515..3024228) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3023515..3024228) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3023532) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3024218..3024964) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3024218..3024964) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3024996..3025015) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025008) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3025032..3025035) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3025198..3025341) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3025198..3025341) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3025219) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3025342..3025427) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3025417..3025428) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3025427) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3025429..3025659) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3025466..3025470 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3025486..3025505 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3025495 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3025545..3027155 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3025545..3027155 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3025647..3025665) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025659) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3025661..3025835) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3025679..3025686) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3025822..3025841) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025835) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3025855..3025863) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3027142..3029910 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3027142..3029910 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3029959) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3030036..3030893) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3030036..3030893) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3030899..3031675) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3030899..3031675) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3031701..3031720) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3031723) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3031725..3031797) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3031735..3031742) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3031799..3031898) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3031842) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3031899..3032240) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3031899..3032240) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3032262..3032281) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032281) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3032295..3032302) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3032317..3032700) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3032317..3032700) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3032722..3032741) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3032729..3032748 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3032733 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3032742) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3032756..3032763) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3032823..3032842 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3032826 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3032875) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3032875..3033285 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3032875..3033285 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3033286..3033369 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3033327 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3033425..3033733) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3033425..3033733) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3033426) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3034077..3034913 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3034077..3034913 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3034293..3034300 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3034315..3034334 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3034318 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3034912 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3034960..3035352) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3034960..3035352) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3034966) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3035425..3035850) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3035425..3035850) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3035911..3035930) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035927) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3035929..3036013) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3035945..3035952) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3035992 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3035995..3036014 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3036005..3036024) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3036013) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3036015..3037099) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3036038..3036043) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3036042..3037106 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3036042..3037106 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3037107..3037991 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3037129..3037938) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3037129..3037938) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3037144) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3037972..3038784) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3037972..3038784) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3038785..3038864) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3038815..3038822 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3038836..3038855 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3038845 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3038858..3038876) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3038864) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3038890..3038897) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3038947..3039948) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3038947..3039948) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3038953) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3040003..3040022) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3040027) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3040029..3040113) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3040114..3040395) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3040114..3040395) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3040410..3040520) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3040410..3040520) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3040551..3040569) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040573) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3040585..3040590) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3040666..3040672 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3040686..3040705 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3040702 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3040745..3041158 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3040745..3041158 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3041180..3042370 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3041180..3042370 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3042461..3043867) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3042461..3043867) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3042758) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3043900..3043919) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043918) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3043934..3043937) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3043973..3045445) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3043973..3045445) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3045626..3046984) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3045626..3046984) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3045640) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3046984..3047553) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3046984..3047553) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3047572..3047583) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3047590) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3047597..3047603) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3047660..3047827) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3047660..3047827) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3047737..3048201) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3047737..3048201) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3048231..3048250) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3048236) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3048264..3048271) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3048402..3048405 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3048420..3048439 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3048424 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3048483..3049697 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3048483..3049697 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3049313..3049331) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049314) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3049345..3049352) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3049563..3049569 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3049583..3049602 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3049585 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3049709..3050059 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3049709..3050059 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3050052 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3050111..3050119 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3050133..3050141 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3050140 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3050182..3050191 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3050204..3050219 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3050208 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3050240..3050821 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3050240..3050821 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3050338..3050357) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050348) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3050371..3050379) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3050802 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3050862..3051284) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3050862..3051284) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3050881) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3051319..3051334) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3051338) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3051347..3051356) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3051395..3052246) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3051395..3052246) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3051404) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3051646) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3051883..3051885 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3051902..3051921 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3051903..3052249 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3051903 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3052241..3052244 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3052251..3052386 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3052251 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3052280) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3052286..3052295) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3052387..3052878 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3052387..3052878 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3052616..3052621 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3052637..3052655 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3052648 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3052739..3053647) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3052875..3053393 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3052875..3053393 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3053198 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3053396 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3053552..3053683 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3053552..3053683 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3053680..3054114) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3053680..3054114) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3053692) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3054163..3054182) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3054170) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3054172..3054469) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3054197..3054204) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3054243..3054247 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3054264..3054283 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3054276..3054356 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3054277 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3054357..3055805 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3054357..3055805 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3054469) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3054470..3054488) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3054471..3054814) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3054504..3054510) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3054792..3054810) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3054814) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3054826..3054831) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3055794 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3055826..3056599) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3055826..3056599) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3055848) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3056674..3056677 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3056693..3056712 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3056697 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3056744..3057127 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3056744..3057127 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3057114 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3057162..3057803) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3057162..3057803) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3057212) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3057871..3058272) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3057871..3058272) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3058321..3058340) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3058331) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3058333..3058406) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3058355..3058360) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3058407..3060116) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3058407..3060116) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3060113..3060487) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3060113..3060487) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3060484..3060801) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3060484..3060801) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3060802..3060886) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3060886) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3060888..3060901) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3060888..3060981) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3060982..3061146) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3060982..3061146) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3061069..3061087) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3061081) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3061099..3061107) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3061147..3061318) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3061319..3061501) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3061319..3061501) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3061502..3061648) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3061636..3061655) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3061648) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3061650..3061764) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3061670..3061677) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3061751,3061753) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3061778 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3061781..3061785 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3061798..3061986) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3061798..3061986) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3061809) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3061976 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3062012..3062030) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3062023) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3062044..3062050) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3062059..3062559) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3062059..3062559) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3062595..3062614) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3062602) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3062628..3062634) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3062694..3063827) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3062694..3063827) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3062712) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3063854..3063873) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3063861) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3063924..3063942) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3063940) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3063956..3063963) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3064019..3065044) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3064019..3065044) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3064032) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3065060..3065848) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3065060..3065848) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3065874..3065893) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3065880) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3065882..3066093) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3065907..3065914) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3066094..3066255) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3066094..3066255) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3066268..3066286) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3066288) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3066300..3066306) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3066349..3067023) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3066349..3067023) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3066364) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3067076..3067216) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3067076..3067216) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3067347..3068030) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3067347..3068030) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3068407..3068411 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3068416..3069447) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3068416..3069447) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3068426..3068445 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3068432) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3068444 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3069475..3069493) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3069488) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3069490..3069607) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3069509..3069514) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3069549..3069554 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3069566..3072226 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3069566 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3069570..3069588 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3069643..3070953) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3069643..3070953) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3069652) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3070977..3070996) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070984) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3070987..3071727) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3070987..3071727) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3071010..3071019) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3071358) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3071360..3071368) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3071382..3071390) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3071482..3071497) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3071490) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3071510..3071519) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3071728..3071855) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3071856..3072086) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3071856..3072086) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3072087..3072349) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3072222..3072241 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3072228 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3072256..3072729 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3072256..3072729 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3072333..3072352) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3072349) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3072351..3072734) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3072367..3072370) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3072763..3073161) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3072763..3073161) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3072779) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3073153..3073171) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3073162) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3073185..3073191) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3073185..3074606) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3073185..3074606) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3074632..3075495) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3074632..3075495) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3075496..3075571) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3075572..3077080) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3075572..3077080) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3077097..3077642) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3077097..3077642) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3077639..3078151) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3077639..3078151) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3078152..3078313) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3078314..3078526) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3078314..3078526) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3078572..3079306) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3078572..3079306) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3079120..3079220 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3079180 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3079314..3079697) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3079314..3079697) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3079386..3079404) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3079388) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3079698..3079968) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3079930..3079939 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3079939 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3079944..3079963) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3079953..3079972 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079968) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3079970..3080091) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3079976..3079983) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3080120..3080749) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3080120..3080749) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3080136) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3080793..3080812) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3080816) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3080827..3080834) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3080884..3082131) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3080884..3082131) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3080907) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3082173..3082192) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3082190) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3082192..3082276) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3082207..3082212) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3082321) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3082338..3082880) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3082338..3082880) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3082893..3083342) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3082893..3083342) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3083343..3083442) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3083434..3083453) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3083442) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3083467..3083474) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3083499..3083951) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3083499..3083951) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3083968..3083987) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3083986) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3084002..3084005) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3084027..3084584) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3084027..3084584) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3084611..3084629) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3084624) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3084645..3084650) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3084663..3085703) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3084663..3085703) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3084668) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3085704..3085768) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3085758..3085777) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085768) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3085770..3085859) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3085793..3085797) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3085860..3086303) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3085860..3086303) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3086370..3087044) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3086370..3087044) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3086806..3086824) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3086813) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3086839..3086845) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3087076..3087093) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087077) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3087109..3087114) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3087150 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3087154..3087173 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3087185..3087547 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3087185..3087547 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3087560) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3087564..3087851) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3087564..3087851) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3087852..3087910) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3087908..3087927) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3087911..3088777) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3087911..3088777) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3087924) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3087940..3087949) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3088779..3089849) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3088779..3089849) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3088782) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3089850 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3089877..3089896) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089901) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3089903..3090014) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3089910..3089916) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3089946..3089965 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3089960 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3089975..3090361 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3089975..3090361 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3089996..3090014) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3090014) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3090028..3090035) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3090429..3090437 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3090448..3090466 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3090449 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3090483..3091037 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3090483..3091037 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3090967..3090971 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3090972 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3091016 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3091071..3092030) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3091071..3092030) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3091093) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3092068..3092086) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3092082) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3092101..3092107) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3092112..3093860) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3092112..3093860) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3092586..3092604) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3092594) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3092619..3092625) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3093861..3093951) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3093935..3093954) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093951) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3093968..3093975) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3094094) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3094099..3094686) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3094099..3094686) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3094775..3094975) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3094775..3094975) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3094788) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3094976..3095053) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3095049..3095068) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3095053) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3095082..3095089) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3095094..3096377) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3095094..3096377) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3096378..3096680) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3096408..3096569) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3096408..3096569) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3096660..3096679) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096680) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3096695..3096699) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3096784..3097749) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3096784..3097749) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3096790) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3097366..3097375 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3097388..3097407 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3097396 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3097780..3099069) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3097780..3099069) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3099070..3099429) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3099448..3100086) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3099448..3100086) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3099474) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3100087..3100205) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3100206..3101063) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3100206..3101063) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3101064..3101190) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3101172..3101191) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3101190) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3101205..3101212) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3101244..3101618) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3101244..3101618) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3101658..3101676) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3101672) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3101674..3102313) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3101675..3101678 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3101687..3101695) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3101694..3101713 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3101707 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3101721..3101726 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3101742..3101761 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3101752 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3101784..3102305 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3101784..3102305 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3102248..3102251 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3102266..3102285 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3102280 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3102303..3102322) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3102313) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3102324 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3102337..3102344) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3102387..3103994) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3102387..3103994) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3102400) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3103995..3104182) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3104170..3104189) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3104182) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3104204..3104211) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3104236..3104757) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3104236..3104757) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3104292) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3104758..3104860) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3104841..3104860) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3104860) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3104862..3104939) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3104876..3104879) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3104940..3106079) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3104940..3106079) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3106076..3108193) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3106076..3108193) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3108194..3108252) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3108253..3108272) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3108266) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3108286..3108293) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3108292..3108298 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3108312..3108323 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3108317 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3108348..3109544 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3108348..3109544 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3108540..3109418) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3109408..3109426) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109419) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3109442..3109447) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3109557..3110519 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3109557..3110519 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3110533..3110539 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3110554..3110572 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3110554 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3110600..3110872 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3110600..3110872 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3110606) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3110862 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3110907..3111313 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3110914..3111438) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3110914..3111438) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3110936) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3111448..3113175) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3111448..3113175) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3113209..3113228) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3113223) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3113242..3113248) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3113264..3114766) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3113264..3114766) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3114790..3114808) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3114808) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3114823..3114829) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3114853..3115225) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3114896) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3115252..3115923) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3115252..3115923) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3115270) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3115920..3116474) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3115920..3116474) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3116500..3117963) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3116500..3117963) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3117953..3121639) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3117953..3121639) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3121670..3121689) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3121694) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3121696..3121825) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3121835..3122311) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3121835..3122311) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3121870) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3122334..3122353) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3122346) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3122368..3122371) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3122418 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3122421..3122440 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3122455..3123174 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3122455..3123174 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3123158 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3123206..3123922) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3123206..3123922) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3123208) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3123278) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3123948..3123967) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3123960) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3124021..3125208) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3124021..3125208) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3125238..3125257) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3125256) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3125344..3127014) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3125344..3127014) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3125346) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3127011..3127439) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3127011..3127439) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3127507..3127521 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3127507..3127526) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3127514 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3127523) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3127543..3127546) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3127578..3127597) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3127590) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3127619,3127626) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3127620..3127625 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3127626..3130104 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3127627..3129003) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3127627..3129003) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3129042..3130397) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3129042..3130397) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3130433..3130452) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130451) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3130465..3130474) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3130577..3130596 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3130578 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3130623) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3130627..3131772 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3130627..3131772 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3131631..3131635 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3131652..3131671 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3131659 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3131742) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3131756..3131875 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3131756..3131875 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3131860 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3131905..3131973 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3131974..3132447 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3131974..3132447 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3132436 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3132479..3133351) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3132479..3133351) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3132490) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3132556) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3133412..3134242) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3133412..3134242) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3134243..3134338) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3134326..3134345) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134337) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3134358..3134365) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3134383..3134388 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3134404..3134422 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3134406 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3134444..3136519 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3134444..3136519 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3136572) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3136696..3136811) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3136739) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3136812..3137330) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3136812..3137330) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3137344..3138003) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3137344..3138003) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3138026..3138029 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3138039..3138058) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3138044..3138063 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3138047 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3138057) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3138059..3138342) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3138073..3138080) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3138112..3138300 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3138112..3138300 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3138289 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3138343..3138762) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3138343..3138762) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3138812..3138831) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138823) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3138846..3138853) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3138882..3140798) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3138882..3140798) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3140076..3140094) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140081) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140111..3140115) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3140829) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3140852..3141073) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3140852..3141073) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3141105..3141326) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3141105..3141326) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3141358..3141620) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3141369 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3141401) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3141408..3141563) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3141408..3141563) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3141570..3141573 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3141582..3141595 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3141589 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3141597..3141616) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3141620) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3141630..3141636) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3141643..3143043) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3141643..3143043) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3143043..3143513) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3143043..3143513) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3143469) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3143625..3144125) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3143625..3144125) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3143628) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3144161..3145462) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3144161..3145462) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3145486..3145505) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145500) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3145502..3145623) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3145521..3145523) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3145624..3145848) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3145624..3145848) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3145849..3145933) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3145922..3145941) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145932) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3145956..3145959) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3145999..3146005 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146020..3146031 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146021 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3146063..3146839 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3146063..3146839 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3146825 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3146927..3146934 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146949..3146968 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3146953..3151179 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3146953 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3146983..3147873) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3146983..3147873) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3147873..3147973) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3147913) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3148041..3148886) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3148041..3148886) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3148204) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3148935..3149834) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3148935..3149834) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3149877..3149896) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3149880) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3149910..3149917) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3149981) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3149981..3150952) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3149981..3150952) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3150987..3151006) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3151012) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3151022..3151026) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3151100..3151111) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3151103) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3151125..3151131) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3151174..3151193 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3151181 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3151222..3151986 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3151222..3151986 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3151973 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3151993,3152000) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3151994..3151999 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3152000..3152052 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3152002..3153240) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3152002..3153240) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3153282..3153301) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3153294) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3153313..3153320) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3153450..3154862) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3153450..3154862) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3153457) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3154862..3156562) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3154862..3156562) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3155531..3155547) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3155543) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3156636..3158183) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3156636..3158183) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3156643) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3158227) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3158229..3158409) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3158230..3158248) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3158410..3159684) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3158410..3159684) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3159685..3159767) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3159767) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3159780..3159798) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3159860) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3159861..3160325) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3159861..3160325) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3160326..3160436) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3160418..3160437) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3160436) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3160452..3160459) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3160647) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3160649..3161104) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3160649..3161104) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3160739..3160758 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3160747 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3161097..3161948) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3161097..3161948) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3161962..3162909) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3161962..3162909) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3162909..3163649) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3162909..3163649) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3163667..3163672 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3163673 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3163674..3164693) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3163674..3164693) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3163687..3163705 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3164557..3164566 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3164579..3164594 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3164590 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3164696..3165418) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3164696..3165418) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3165411..3166532) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3165411..3166532) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3166532..3167401) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3166532..3167401) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3167402..3168571) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3167402..3168571) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3168592..3170016) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3168592..3170016) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3170021..3170791) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3170021..3170791) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3170826..3170845) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3170840) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3170859..3170868) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3170959..3170964 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3170980..3170998 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3170982..3171110 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3170982 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3171111..3171656 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3171111..3171656 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3171642 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3171700..3172071) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3171700..3172071) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3171718) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3172133..3173455) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3172133..3173455) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3173475..3173792) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3173475..3173792) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3173821..3173840) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3173832) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3173854..3173860) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3173895..3173902 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3173918..3173937 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3173921 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3173960..3175330 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3173960..3175330 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3175355..3176032) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3175355..3176032) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3175369) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3175859..3175878) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3175875) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3175894..3175899) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3176046..3176852) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3176046..3176852) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3176345..3176363) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176359) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3176378..3176384) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3176881..3176900) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176887) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3176916..3176923) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3176942..3177475) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3176942..3177475) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3177523..3178158) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3177523..3178158) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3178151..3178489) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3178151..3178489) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3178511..3178530) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178522) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3178545..3178552) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3178573..3178576 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3178591..3178610 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3178591 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3178633..3179448 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3178633..3179448 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3179427 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3179503) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3179538..3179786) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3179538..3179786) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3179558) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3179804) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3179806..3179879) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3179814..3179820) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3179880..3181319) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3179880..3181319) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3181316..3182701) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3181316..3182701) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3182720..3182729) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3182734) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3182736..3182800) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3182779..3182796) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182800) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182812..3182819) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3182842..3182861) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182860) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182875..3182882) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3182941..3182944 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3182951 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3182959..3182978 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3183003..3183773 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3183003..3183773 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3183774..3184841 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3183812..3184642) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3183812..3184642) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3183813) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3184668..3184687) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3184674) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3184682..3184984) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3184682..3184984) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3184702..3184709) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3184985..3185123) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3185108..3185127) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3185123) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3185438..3185446 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3185457..3185475 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3185458 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3185514..3185591 /gene="vpr" /old_locus_tag="BSU_38090" /created_by="User" /modified_by="User" /transl_table=11 /locus_tag="PG10_BSU_38090-3'_ext" /translation="MKKGISQQTPPAISDTIGAYLQNDA*" /label="PG10_BSU_38090-3'_ext" gene 3185514..3185591 /gene="vpr_3'-chimera" /old_locus_tag="BSU_38090" /created_by="User" /locus_tag="PG10_BSU_38090-3'_ext" /label="PG10_BSU_38090-3'_ext" SCAR 3185524..3185525 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_017" CDS complement(3185527..3186528) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3185527..3186528) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3186529..3186690) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3186702..3187451) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3186702..3187451) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3186735) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3187469..3187488) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3187486) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3187503..3187506) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3187557..3188738) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3187557..3188738) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3187571) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3188739..3188870) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3188864..3188879) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3188870) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3188891..3188900) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3189105..3189112 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3189123..3189233 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3189123..3189142 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3189123 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3189234..3189497 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3189234..3189497 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3189387 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3189503 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3189540..3189914) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3189540..3189914) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3189551) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3189916..3190530) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3189916..3190530) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3190544..3192493) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3190544..3192493) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3191757..3191776 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3191763 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3192187..3192287 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3192247 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3192357 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3192521..3193486) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3192521..3193486) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3193487..3193555) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3193542..3193561) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3193555) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3193557..3193742) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3193574..3193578) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3193673..3193678 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3193694..3193712 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193699 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3193733..3193752) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3193742) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3193744..3193853) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3193767..3193771) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3193809 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3193838..3193857) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3193853) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3193873..3193877) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3193931..3193949) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3193936..3193942 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3193948) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3193957..3193975 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193960 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3193965..3193970) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3194002..3194247 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3194002..3194247 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3194229 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3194318..3195859) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3194318..3195859) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3194347) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3195863..3197035) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3195863..3197035) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3197053..3197071) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197075) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3197086..3197092) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3197116..3197499) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3197116..3197499) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3197517..3198188) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3197517..3198188) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3198210..3198229) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3198219) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3198245..3198248) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3198329..3198332 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3198347..3198366 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3198356..3198543 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3198356 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3198544..3198702 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3198544..3198702 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3198703..3199087 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3199068..3199073 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3199089..3199107 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3199089 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3199145..3199453 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3199145..3199453 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3199231) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3199235..3199335) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3199275) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3199450..3200991 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3199450..3200991 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3200982 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3201022..3201624) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3201022..3201624) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3201036) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3201625..3201906) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3201907..3203157) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3201907..3203157) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3202003) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3203176..3204333) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3203176..3204333) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3203249..3203268) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3203276) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3204330..3205775) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3204330..3205775) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3205809..3205828) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3205819) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3205842..3205849) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3205932..3206600) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3205932..3206600) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3205941) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3206597..3207415) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3206597..3207415) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3207423..3208328) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3207423..3208328) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3208063..3208082) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3208074) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3208369..3208388) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3208379..3208386 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3208390) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3208398 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3208400..3208419 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3208404..3208411) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3208434..3208820 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3208434..3208820 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3208802..3209479 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3208802..3209479 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3209451 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3209523..3209530 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3209541 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3209544..3209563 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3209583..3210782 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3209583..3210782 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3210816..3211013 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3210816..3211013 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3210992 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3211048..3212238) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3211048..3212238) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3211063) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3211147) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3212262..3212281) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3212278) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3212298..3212305 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3212314 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3212319..3212338 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3212359..3212739 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3212359..3212739 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3212637 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3212708 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" downshifts complement(3212784) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3212799..3212800 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_020" promotor_-35 <3212800..3212803 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3212818..3212837 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3212837 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3213049..3213056 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3213069..3213088 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3213069 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3213121..3214500 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3213121..3214500 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3214209..3215412) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3214554..3215396 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3214554..3215396 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3215447..3216307) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3215447..3216307) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3215457) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3216291 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3216329..3216347) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3216347) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3216362..3216368) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3216417..3217130) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3216417..3217130) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3216532..3216533 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3216553..3216570 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3216555 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3217158..3217169) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3217159) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3217184..3217190) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3217205..3217211 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3217226..3217245 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3217236 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3217281..3217796 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3217281..3217796 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3217797..3218003 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3217797..3218003 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3217963 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3218045..3219286 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3218045..3219286 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3219377..3219385 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3219396..3219414 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3219407 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3219442..3220809 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3219442..3220809 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3220786 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3220839..3221471) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3220839..3221471) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3220857) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3221507..3221522) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3221515) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3221535..3221543) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3221613..3222548) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3221613..3222548) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3221625) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3222292..3222301 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222315..3222334 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3222319 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3222549..3222636) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3222619..3222638) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3222636) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3222654..3222658) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3222681..3222693) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3222681) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3222708..3222714) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3222711..3222845) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3222711..3222845) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3222792..3222799 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3222813..3222832 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3222822 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3222825..3222929 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3222924..3222933 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3222931 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3222945..3222960 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3222967) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3222969..3222983) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3222995..3223144 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3222995..3223144 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3223162..3224673 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3223162..3224673 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3224670..3225857 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3224670..3225857 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3225874..3226110 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3225874..3226110 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3226110..3227288 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3226110..3227288 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3227289..3227378 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3227379..3228137 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3227379..3228137 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3228105 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3228139..3229366) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3228185..3228192 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3228206..3228225 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3228219 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3228278..3229369 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3228278..3229369 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3229271 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3229359 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3229403..3230731) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3229403..3230731) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3229411) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3230728..3231060) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3230728..3231060) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3231079..3232437) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3231079..3232437) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3232453..3232761) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3232453..3232761) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3232806..3232825) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232822) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3232839..3232845) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3232890) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3232890..3234815) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3232890..3234815) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3233553..3233562 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3233576..3233595 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3233584 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3234888..3234905) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3234912) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3234920..3234927) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3234978..3235136) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3234978..3235136) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3235005) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3235165..3235755) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3235165..3235755) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3235783..3235801) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235794) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3235815..3235821) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3235824..3235830 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235846..3235864 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3235849 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3235884..3237527 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3235884..3237527 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3236021..3237570) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3237522 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3237572..3237663) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3237574..3237580 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3237588 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3237595..3237614 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3237615) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3237632..3238834 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3237632..3238834 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3237665..3238830) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3237708) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3238831..3239607) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3238831..3239607) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3239604..3240491) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3239604..3240491) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3240498..3240686) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3240498..3240686) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3240683..3240889) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3240683..3240889) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3240886..3241206) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3240886..3241206) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3241019..3241028 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3241041..3241060 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3241043 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3241199..3241735) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3241199..3241735) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3241763) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3241764..3241779) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3241791..3241800) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3241866..3241873 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3241887..3241906 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3241896 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3241947..3243320 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3241947..3243320 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3242227..3242769) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3242757..3242776) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242769) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3242791..3242798) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3243155 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3243335..3244165) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3243335..3244165) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3243341) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3244184..3244202) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3244199) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3244217..3244223) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3244243) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3244245..3244264) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3244251..3245978) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3244251..3245978) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3244350) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3245975..3247678) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3245975..3247678) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3247678..3248694) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3247678..3248694) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3248568..3248586) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3248577) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3248602..3248607) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3248678..3250084) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3248678..3250084) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3250085..3250293) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3250276..3250295) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3250293) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3250295..3250403) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3250309..3250314) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3250400..3250419) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3250415) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3250433..3250440) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3250561..3250568 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3250578 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3250583..3250601 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3250640..3251992 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3250640..3251992 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3251591..3254073) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3251977 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3252068..3252087 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3252074 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3252114..3253802 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3252114..3253802 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3253800..3253809 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3253821..3253836 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3253825 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3253860..3254060 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3253860..3254060 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3254061..3255005 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3254074..3254913) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3254074..3254913) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3254939..3254957) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3254957) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3254970..3254977) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3254972 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3255020..3256117) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3255020..3256117) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3255021) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3256150..3256169) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3256167) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3256169..3256237) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3256182..3256189) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3256238..3257131) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3256238..3257131) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3257158..3257177) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3257177) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3257191..3257198) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3257205..3257210 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3257226..3257244 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3257235 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3257252..3257258 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3257273..3257291 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3257279 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3257315..3258772 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3257315..3258772 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3258198..3258216) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3258213) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3258231..3258236) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3258753 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3258797 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3258814..3259650) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3258814..3259650) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3258832) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3259727..3259829) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3259727..3259829) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3259753) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3259855..3259874) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259866) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3259868..3260609) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3259888..3259894) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3259946..3259953 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3259966..3259984 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3259975 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3259985..3260070 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3260046..3260053 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3260067..3260086 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3260072 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3260218..3260760 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3260218..3260760 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3260585..3260604) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3260609) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3260618..3260627) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3260750 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3260795..3261117 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3260835..3261854) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3260835..3261854) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3260853) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3261880..3261899) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3261894) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3261914..3261917) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3261969..3262475) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3261969..3262475) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3262481..3262500) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3262503) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3262505..3262508 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3262514..3262520) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3262523..3262542 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3262526 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3262605..3263480 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3262605..3263480 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3262855..3262943) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3262877) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3262903..3263003) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3262943) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3263558..3264031 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3263558..3264031 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3264049..3265269 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3264049..3265269 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3265256..3265912 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3265256..3265912 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3265910..3265915 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3265929..3265948 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3265932 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3265962..3267194 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3265962..3267194 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3265979) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3267179 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3267240..3267249 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3267262..3267277 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3267264..3267486 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3267264 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3267443 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3267497..3267503 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3267516..3267616 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3267516 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3267518..3267536 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3267595..3267602 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3267616..3267634 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3267618..3267715 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3267618 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3267716..3267979 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3267716..3267979 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3267743..3267746 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3267761..3267780 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3267773 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3267927 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3267971 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3268046..3268055 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3268061 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3268067..3268082 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3268108..3268596 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3268108..3268596 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3268601..3268608 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3268622..3268641 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3268632 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3268662..3268768 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3268662..3268768 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3268763 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3268851..3269984 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3268851..3269984 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3269124..3269367) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3269362..3269381) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3269371) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3269396..3269403) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3269990..3269997 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3270012..3270031 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3270018 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3270053..3270159 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3270053..3270159 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3270106 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3270160..3270236 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3270237..3271373 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3270237..3271373 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3271360 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3271426..3272199) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3271426..3272199) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3271436) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3272216..3272866) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3272216..3272866) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3272863..3273579) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3272863..3273579) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3273603..3275021) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3273603..3275021) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3274189..3274207) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274208) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3274223..3274228) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3275022..3275106) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3275090..3275108) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3275106) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3275124..3275129) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3275175..3276023) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3275175..3276023) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3275185) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3276024..3276209) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3276198..3276217) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276209) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3276211..3276936) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3276233..3276237) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3276371..3276378 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3276391..3276410 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3276400 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3276410..3276512 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3276410..3276512 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3276513..3276616 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3276588..3276594 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3276608..3276619 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3276618 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3276639..3277832 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3276639..3277832 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3276923..3276941) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276939) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3276954..3276961) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3277608 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3277828 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3277874..3278302) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3277874..3278302) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3278303..3278545) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3278303..3278545) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3278546..3278609) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3278598..3278613) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278609) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3278625..3278634) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3278642 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3278690..3278980) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3278690..3278980) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3278696) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3279005..3279024) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279022) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3279030..3281090) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3279030..3281090) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3279038..3279045) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3281119..3281137) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3281123) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3281152..3281158) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3281183..3281188 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3281202 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3281204..3281222 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3281216..3281290 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3281291..3282571 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3281291..3282571 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3282572..3282711 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3282668 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3282729..3283457) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3282729..3283457) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3282746) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3283488..3283507) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283499) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3283521..3283528) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3283645..3283752) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3283688) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3283753..3284586) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3283753..3284586) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3284617..3284636) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284636) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284650..3284657) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3284682..3285362) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3284682..3285362) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3285409..3285428) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3285418) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3285442..3285449) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3285510..3285513 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3285528..3285547 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3285528 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3285569..3286855 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3285569..3286855 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3286300..3286318) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3286308) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3286332..3286339) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3286826 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3286874..3288313) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3286874..3288313) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3286897) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3288337..3288356) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3288354) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3288395..3289543) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3288395..3289543) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3289570..3289586) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3289586) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3289588..3289672) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3289601..3289606) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3289673..3289861) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3289673..3289861) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3289892..3290023) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3289892..3290023) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3290035..3290496) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3290035..3290496) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3290512..3290808) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3290512..3290808) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3290836..3291324) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3290836..3291324) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3291342..3291794) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3291342..3291794) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3291795..3291863) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3291864..3292193) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3291864..3292193) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3292194..3292315) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3292316..3292732) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3292316..3292732) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3292783..3293151) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3292783..3293151) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3293145..3293615) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3293145..3293615) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3293616..3293940) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3293941..3294369) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3293941..3294369) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3294431..3301435) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3294431..3301435) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3301442..3301456 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3301456 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3301466..3301485) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3301481) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3301500..3301507) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3301597..3302532) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3301597..3302532) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3301818) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3302533..3302653) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3302684..3303130) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3302684..3303130) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3302698) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3303167..3303186) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303174) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3303200..3303207) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3303233..3304642) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3303233..3304642) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3304665..3306494) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3304665..3306494) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3306486..3306586) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3306526) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3306528..3306720) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3306701..3306720) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3306720) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3306722..3306855) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3306733..3306740) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3306877..3307185) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3306877..3307185) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3306900) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3307231..3307674) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3307231..3307674) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3307671..3309380) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3307671..3309380) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3308542..3308561) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3308550) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3309400..3309669) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3309400..3309669) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3309681..3310046) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3309681..3310046) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3310047..3310112) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3310099..3310118) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310112) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310133..3310136) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3310353..3311762) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3310353..3311762) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3310376) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3311763..3311872) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3311896..3312060) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3311896..3312060) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3311945..3311963) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3311960) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3311974..3311982) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3312252..3312271) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312268) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3312284..3312291) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3312300..3312307 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3312322..3312341 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3312325 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3312379..3312825 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3312379..3312825 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3312830 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3312938..3314464 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3312938..3314464 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3314461..3316119 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3314461..3316119 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3316132..3317397 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3316132..3317397 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3317390..3318349 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3317390..3318349 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3318350..3318424 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3318425..3319852 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3318425..3319852 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3319848 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3319896..3321197) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3319896..3321197) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3319913) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3321227..3322408) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3321227..3322408) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3322409..3322488) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3322489..3323160) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3322489..3323160) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3323109..3323112 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3323127 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3323128..3323147 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3323188..3323207) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323203) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3323221..3323228) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3323266..3324207) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3323266..3324207) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3324252..3324271) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3324258) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3324260..3324340) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3324287..3324290) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3324356..3324357 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_018" promotor_-35 3324453..3324459 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324475..3324493 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324485 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3324547..3325932 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3324547..3325932 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3325918 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3325963..3326513 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3325974..3327854) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3325974..3327854) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3325980) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3327855..3327952) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3327943..3327962) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3327952) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3327977..3327984) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3328022..3328273) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3328022..3328273) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3328040) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3328295..3328314) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3328304) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3328337..3328343 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3328357..3328375 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3328358 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3328390..3329211 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3328390..3329211 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3329195 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3329240..3330382) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3329240..3330382) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3329250) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3330383..3330482) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3330470..3330489) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3330481) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3330503..3330510) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3330525..3331862 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3330525..3331862 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3331267..3331867) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3331901..3332380) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3331901..3332380) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3331912) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3332460..3333452) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3332460..3333452) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3332484) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3333442 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3333475..3333494) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333493) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3333509..3333516) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3333515..3333522 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3333536..3333960 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3333536 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3333537..3333556 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3333542..3333954 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3333542..3333954 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3333562) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3333572..3333586) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3333594..3333598) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3333926 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3333961..3334695 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3333961..3334695 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3334695..3334964 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3334695..3334964 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3334968..3335450 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3334968..3335450 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3335471..3337714 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3335471..3337714 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3337711..3338910 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3337711..3338910 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3338666..3338684) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338688) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3338699..3338705) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3338901 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3338974) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3338974..3340206) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3338974..3340206) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3340238..3340257) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3340250) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3340271..3340276) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3340307..3340732) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3340307..3340732) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3340760..3340779) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3340774) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3340792..3340798) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3340924..3340931 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3340941 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3340946..3340965 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3340989..3341444 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3340989..3341444 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3341382 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3341445..3342058 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3341474..3342682) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3341474..3342682) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3341501) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3342683..3342789) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3342790..3343803) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3342790..3343803) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3343804..3343877) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3343862..3343881) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343877) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343894..3343901) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3343897..3344472) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3343897..3344472) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3343921) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3344501..3344520) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3344515) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3344535..3344542) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3344543..3344549 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3344564..3344582 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3344571 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3344603..3345673 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3344603..3345673 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3345671 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3345730..3346161) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3345730..3346161) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3346191..3346198 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3346212..3346231 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3346221..3346387 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3346221 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3346273..3346292) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3346293) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3346307..3346314) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3346388..3346792 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3346388..3346792 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3346409..3347461) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3346762..3347454 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3346762..3347454 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3347494..3348525) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3347494..3348525) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3347506) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3348492..3348495 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3348508 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3348512..3348531 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3348562..3348580) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348580) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3348595..3348601) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3348618..3349766) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3348618..3349766) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3349805..3349824) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3349816) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3349835..3349842) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3349888..3349895 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3349909..3349928 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3349916 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3349962..3350693 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3349962..3350693 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3350686..3352227 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3350686..3352227 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3352256..3353602 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3352256..3353602 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3353055..3353059 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3353075..3353094 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3353084 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3353625..3355031 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3353625..3355031 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3355020 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3355128..3355147 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3355130..3355421 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3355130 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3355394..3355401 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3355416..3355435 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3355423 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3355445..3355452 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3355467..3355486 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3355470) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3355473..3355487) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3355482 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3355495..3355499) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3355495..3356058 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3355495..3356058 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3356072..3357601 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3356072..3357601 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3357428) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3357594 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3357627..3357710) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3357670) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3357711..3359150) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3357711..3359150) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3359164..3359394) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3359164..3359394) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3359395..3359606) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3359603..3359622) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359608) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3359637..3359644) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3359670..3359677 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3359688..3359707 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3359703 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3359738..3360448 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3359738..3360448 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3360476..3360634 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3360476..3360634 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3360711 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3360765..3361487) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3360765..3361487) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3360777) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3361388..3361391 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3361407..3361411 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3361422 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3361508..3362137) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3361508..3362137) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3362138..3362286) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3362287..3363045) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3362287..3363045) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3362735..3362754) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362751) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3362767..3362774) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3363026..3363985) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3363026..3363985) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3363974 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3364021..3364024 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3364029 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3364043..3364192) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3364043..3364192) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3364050) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3364101..3364118 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3364106 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3364187 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3364213..3364232) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364234) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3364247..3364254) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3364527..3364534 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3364549..3364568 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3364553 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3364664..3366589 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3364664..3366589 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3366590..>3366619 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" SCAR 3366619..3366620 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_025" downshifts 3366629 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3366877..3367767) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3366877..3367767) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3366883) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3366945) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3367841..3369244) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3367841..3369244) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3369245..3369466) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3369467..3370672) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3369467..3370672) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3370729..3370747) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3370732) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3370842..3370847 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3370862..3370881 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3370877 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3370913..3372298 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3370913..3372298 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3372280..3372468) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3372280..3372468) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3372585..3372713) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3372585..3372713) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3372637 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3372733..3373935) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3372733..3373935) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3372757) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3373967..3373978) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3373967) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3373993..3373999) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3374017..3374811) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3374017..3374811) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3374833..3375675) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3374833..3375675) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3375662..3377029) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3375662..3377029) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3376256,3376258) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3377019..3378854) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3377019..3378854) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3378862..3379569) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3378862..3379569) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3379570..3379666) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3379654..3379673) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379666) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3379668..3379860) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3379689..3379692) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3379860) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3379870..3379889) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3379952) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3379953..3380025) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3379953..3380025) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3380061..3380137) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3380061..3380137) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3380138..3380218) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3380219..3380290) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3380219..3380290) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3380300..3380375) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3380300..3380375) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3380347..3380363 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3380360 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3380376..3380472) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3380456..3380475) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380472) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3380489..3380496) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3380506..3380607) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3380546) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3380600..3381892) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3380600..3381892) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3380611) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3381932..3381951) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3381952) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3381966..3381973) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3382098..3382517) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3382098..3382517) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3382515..3382526) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3382526) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3382541..3382547) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3382638..3384002) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3382638..3384002) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3382658) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3382702) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3384033..3384052) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3384047) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3384067..3384069) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3384114..3384120 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3384135..3384153 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3384137 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3384172..3384372 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3384172..3384372 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3384342 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3384387..3384708 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3384420..3384623) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3384420..3384623) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3384624..3384924) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3384689..3384692 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3384707..3384726 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3384710 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3384744..3384884 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3384744..3384884 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3384885..3384956 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3384932) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3384935..3384949) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3384957..3384961) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3384957..3386165 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3384957..3386165 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3386146 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3386270..3388327 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3386270..3388327 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3388192 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3388364..3388813) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3388364..3388813) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3388378) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3388810..3390789) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3388810..3390789) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3389291..3389310) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3389294) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3389707..3389714 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3389728..3389746 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3389732..3390398 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3389732 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3390826..3391755) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3390826..3391755) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3391756..3391892) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3391874..3391893) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391892) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3391908..3391913) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3391982..3392131) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3391982..3392131) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3392008) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3392170..3392189) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3392187) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3392203..3392209) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3392210..3392219 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3392232..3392251 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3392238 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3392250) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3392252..3392765) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3392254..3392268) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3392277..3392281) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3392277..3392759 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3392277..3392759 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3392746 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3392789..3393166) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3392789..3393166) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3392791..3393320 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3392810) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3393221..3393240) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393233) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3393254..3393261) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3393302..3393306 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3393320..3393339 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3393322 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3393347..3393361) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393350) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3393371..3394300 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3393371..3394300 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3394286 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3394302..3394303 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_014" CDS complement(3394305..3394859) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3394305..3394859) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3394877..3395257) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3394877..3395257) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3395313..3396248) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3395313..3396248) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3396238..3396247 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3396261..3396280 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3396268 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3396292..3396311) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3396306) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3396307..3397065) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3396307..3397065) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3396324..3396331) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3396598..3397101 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3397060 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3397130..3397369) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3397130..3397369) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3397136) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3397204) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3397413..3397931) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3397413..3397931) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3397972..3398259) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3397972..3398259) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3398260..3398326) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3398325..3398344) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3398326) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3398358..3398363) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3398370..3399470) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3398370..3399470) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3399518..3399537) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3399533) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3399552..3399559) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3399597..3401600) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3399597..3401600) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3401651..3401857) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3401651..3401857) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3401819..3401838) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401844) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3401853..3401859) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3401883..3401902) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3401894) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3401919..3401923) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3401951..3402967) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3401951..3402967) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3403000..3403018) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3403012) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3403034..3403039) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3403143) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3403327..3403332 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3403345..3403426 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3403345 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3403348..3403366 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3403427..3404044 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3403427..3404044 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3404015..3404023 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3404034 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3404037..3404055 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3404056 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3404083..3404931) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3404083..3404931) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3404103) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3404924..3405685) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3404924..3405685) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3405719..3405738) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3405737) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3405829) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3405832..3405840) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3405854..3405862) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3405866..3405874 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3405882 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3405886..3405904 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3405933..3406373 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3405933..3406373 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3406322 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3406424..3407275) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3406424..3407275) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3406443) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3407276..3407396) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3407397..3408116) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3407397..3408116) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3408130..3410016) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3408130..3410016) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3410037..3411416) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3410037..3411416) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3411417..3411547) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3411539..3411558) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411547) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3411574..3411578) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3411602..3411621) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3411612) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3411635..3411642) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3411702..3411708 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3411713..3413998 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3411713 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3411723..3411742 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3411727..3412353) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3411727..3412353) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3411744) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3412350..3413135) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3412350..3413135) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3413180..3413199) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413192) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3413194..3413279) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3413211..3413217) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3413280..3413630) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3413280..3413630) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3413631..3413781) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3413782..3413916) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3413782..3413916) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3413940..3414040 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3413952..3413971) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413962) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3413964..3414032) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3413987..3413994) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3414000..>3414133 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3414000 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3414018..3414037) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3414032) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3414053..3414057) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3414134..3414281 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3414157..3414430) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3414283..3414542 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcagatacaa gattcaatgc agtttgccgc ggttgaaagt ggtctgcgct 226681 tttaccaggc atatgatcaa agcctttctt tgtggccgat tgagtcggaa gcattctatg 226741 tttctactcg ttttggaaaa acacatatca ttgcaagtgg gccaaaggac gcaccttcgc 226801 tcattttgct tcacggaggc cttttcagct ctgcgatgtg gtatccgaat atcgcagcgt 226861 ggagcagtca atttcgtaca tatgcggtcg atataatagg agacaaaaat aaaagtatac 226921 catcagcagc catggaaacg agagctgatt ttgcagaatg gatgaaagat gtctttgatt 226981 ctcttggact tgagacggca catctggccg gcctttcgct tggcgggtcc catatcgtga 227041 atttcttact ccgcgcgcct gaaagagtag agcgggcggt tgttatcagt cccgctgaag 227101 cgtttatttc atttcatccg gatgtctata aatacgctgc agagcttaca ggggcaagag 227161 gagctgaatc atatatcaag tggatcacag gcgacagtta tgatctgcat cctttactgc 227221 aaagacaaat tgtggcgggc gtggaatggc aggatgagca aaggagcctg aagccgacag 227281 aaaacggctt tccgtacgtg ttcacagacc aggaattgaa atcaatacaa gtcccggtac 227341 ttctgatgtt cggtgagcac gaggctatgt accatcagca aatggccttt gagcgggctt 227401 cggtattggt gccgggaatt caggctgaaa tcgtaaagaa cgccggacat ctgttatctc 227461 tggagcagcc agagtacgtc aatcaacgcg tcttgtcctt tttatgcggg gggataaaat 227521 agtaaggaac atgaaaagat tggcattcat ttttcaaaag gtaacaaatg ttgtataata 227581 atagaatttg aatgctgctt tttttgggag cattctatgt tatcatgctt attggagaaa 227641 aatttttcct gtaacgctat tcgatcacta tcgtcaaata atatagatgg ttttacaatt 227701 ggaggtttgg ttacactgtg aattacatcc cctgtatgat tacgatagga aacttcattt 227761 gcggattgct ggcgattcat tccttgctat atcacaacat tcattcagca gtgcttttta 227821 tttttacagg catgttcctt gatttctttg acgggatggc tgctcgtaag ctgaatgccg 227881 tttctgatat ggggagagaa ctggattcgt ttgccgatct ggttacgttt ggggtggctc 227941 cttctatgct tgcttacagt gtcgcgttgt ataccctgcc atttatcggg atcttatgcg 228001 cattgacgta cagcatttgc ggaatgcttc gcctctctaa atttaacatt gaacaaagca 228061 agctcccgac gtttatcggt atgccgattc cgtttgcggg catgtgtctc gttattctaa 228121 gcttcaccta taacccgatc cttctggcaa tcggcacttg cggactctca tatttgatgg 228181 tgagtaaaat aaaattccct cattttaaaa aacatgcggc agaaaacctg gagtctggga 228241 gatggaatta gttcagcagc tcatagcgga ttacggttat ctcgctattt ttttgatgct 228301 ggtattagga attgtaggat tgccgattcc agatgaagtg atgatgaccg ttgttggcta 228361 tttcacgcat accgatgtat tgaattatga gctttcgata ttgattagtt ttgtcggggc 228421 tttgttaggt atgctgatca gctacatgat tggcagaaaa gccggacgcc cgtttatcga 228481 caagtacggc aagtgggtcg gcttaaaaga aaaaagaatg atgaaagtgg aaaaatggat 228541 gaagaaatac ggtccatatt ctcttatttt aggttatttt attcccggcg tcagacatgt 228601 gacgtgctac ttttcgggga tcggcaaaat ggatctgaaa acgtatgttg cgtttgctgc 228661 aatcggcgcc tttttatggt gctttgtttt tattacaatc ggaagggtta tagggattat 228721 tcatgtttaa tacggctgta aagattctgt atcgatcatt gatagagctg acgaatcatc 228781 gtctgtcatc ctatctgatt aaaggatttt gcgagtcgaa aatcagcaaa ccggtcattc 228841 cgcttttctc aaaacatttt cggctgaatt gggatgatgt ggacggtacg gctgctgatt 228901 acggatcgct gtccgaattg ttcattcgac aaataaatct ggagcggcgc cctgtgtcaa 228961 aagaggcgca tgcggtggtc agccctgttg acggtgtggt tcagacggta ggaatcatca 229021 acccgaatca aacctttacg gtgaagggaa aagattactc attcgctgag ctgaccggct 229081 gtaaaagcgc agaccatcaa tacaacggcg gatatttcgt cgtgctgtat ttaagcccga 229141 ggcattatca ccgtttccat tctccgatca gctgcaggta tcaaaagctg gccgagctcg 229201 gaaatcgctc atacccggta aatcaactag gcttaaaata cgggaaagat gtgctgtcga 229261 aaaattatcg gtttgtgtac gagctgaata gcggcagccg aaatgtcctg atgattcctg 229321 tcggcgcgat gaatattaat tctatcgtgc agacgaatac ccgtactgaa ttggagatcg 229381 gcgaggagct gggatacttt tcatttggct caaccgtcat tttggttttt gaaaaagacg 229441 cgttccagcc gtccgcccat ttagcagaag gccaagaagt ccaagtcgga gaactgatag 229501 gttacgaaga ataaaaagag gagcttgcat aaacgcagcg cctctttttt tgaagaaagg 229561 tgagattcat ggagaaacaa atcatcagct ggattacaga ttatcagaac accggagatg 229621 aagccgtcct gcggcaagtg cgagaagtgt gctggccgat cgttgaagcg gttttgcaag 229681 agaaagtaat ggatgatgaa caagcgaaca atttgcgcga aaaaggaatc gagcggtttc 229741 cattcatcat cagcaaatac caagcggatg tgcagcttcc ggttgagaca tttttacaaa 229801 atacgtatcg gttttacttt catcaggtga tgagagaatc cagctaaagc ttctttcaac 229861 agagaagctt ttttttgttg gcaggaaaag gaaacttttt ctatatctat ctcgtaatga 229921 ctagagaacc tagcagaaaa ggagagatag aattgaaacg aatgatagtg agaatgaccc 229981 tgccgctgct gatcgtttgt ctggcgtttt cttctttttc agcctcagcc cgtgctgctt 230041 ctgaagaaaa atattgggat cactggattg aacgacatgc acagcctctg gatgcttcca 230101 atgcttcaaa caaagacctt cgatttctaa aaaaggtgct gaagggaaaa cgaatcgttc 230161 agttaggaga aaccacacac ggtgctggcg aaatcaatgc cacaaaggtc agaatgatca 230221 aatacctcca cgaagagctg ggatacgatg tattggcctt tgaatccggc tttcctgata 230281 caaatgcatc ctaccttaat atggaccaat taacccctaa aagcacgatg aaaaactcca 230341 tttacgctgt atggcacaca gaagatgtcg tcgaattgtt tgattacatg aaagagcaaa 230401 aagagaaagg cgatccgctg atccttaccg gttttgatat tcaaagcatg aagaattcat 230461 tcaatgtagc tgcgactcaa tgggtaaaag cggtggaccc tgagaaagca gagttgctct 230521 cccaatcaga aaatgatttt tcaacattag tgacagacag caatacgttt gatgaatttt 230581 cgcaaaagaa ggaaaagctt gtgaaaaact atcagaagct gatcaagttc actaaaacac 230641 atgcttcaga gctaaaagaa aaccttccaa aagagccgaa agcttatgag atgtttatgc 230701 attctcttca gctgagaatt gacgtaatgg aaacatatat gctggaagaa atgaaagaaa 230761 aactagagga gtatccggag aatattgagg atttttcatt ctttatgaga gaccgcatga 230821 tggctgaaca atttcagtgg gtagccgaca ccctttatcc gaaaaagaaa atcattgtct 230881 ggggccacaa ttaccatcta cgcaaacaga atacgaagat gataaaggac tgggtacagc 230941 taaacggccc taacatgggt gattatttgc cggagcggct gaaaaaacaa acatatacga 231001 ttggcattta tgcttactca ggtgcgagtc ttgatagctc cgataataag actgttaagc 231061 cggttacaag cccgccgccg tctgggagcc ttgaagcttt gctgaaagcg gcggaccgac 231121 cggctgtttt tgttgatttt ctccatacaa aaaacaagaa aggcacttcg tggatgtata 231181 ccccgcggac tgcgctctat tgggggtaca tggaagagca gatgatcctg aaggaacaat 231241 atgacggtgt catttggctg gagcatatca cgccctctgt cattatcaag tgagcggtgt 231301 cccctgtggt aaacagggga tttttacata tcgcaaaaat aatcaaaaca tataatccgt 231361 gatccattat tctaaaacag aaaggagatt ggagcgtgca atgtattatg aaaaagctgt 231421 ccagaaaaca atcaattgga ttgaatcaca tttacatgag caaatatcaa acgaggatat 231481 tgttaacgtt tcaagctttt caaaattcca ttttcatcgg atttttcaaa aagaagtcgg 231541 catgtcggtt gcttcttata ttcggttaag acgtcttgcg aatgcggcgg cagctttgct 231601 ttatacagat catcgtatta tcgatattgc tttgtattat cagtttgaat ctcaagaagc 231661 atttacgagg acgttcaaaa agatgtatca catgccgcca ggagcatacc gaacatttat 231721 gaaacgcttt acttcaaaaa aggaggaatc ttacatggag aaaaaaatga aaggctgggt 231781 attgagcggg agccatccgt tccaattcga aatggggatt gaccgggaaa atgtacatca 231841 gggaaaagct tcagggtatt taaagtcaac gatggttcag gatatcggtg aatttgcgac 231901 gatgatgcag caattcaaag cagatcgcta tctaggaaaa aggcttcgtc tatcaagttt 231961 tatcaaaaca aagggggtgc agcattttgc ctcactttgg atgcgggttg acagtgctgc 232021 tgatgatgtt ctccaatttg ataatatgag caacagacct attaccggaa caaccaattg 232081 gaatcattat gctatcgttt tagatgtccc agaaaatagc gctgtgatat cttttggcgt 232141 tcaattatct gggccgggtc aggtgtggat ggatcatgtt gtttttgaag aggtagatga 232201 gagcgttcct tcaacaaacc ttgaaatgcc gggagaactt ttagatgaac cggtaaattt 232261 atcttttgaa gaggaactac aaaaatagtt ttcagacaac tacttttatt agtgagttaa 232321 tggaaaatac tatttgttat taataaaccc ttgtgctgct taggtttgta agagcttgga 232381 tatttttatc agtctgggcg gatctgttca tctttgcggc attttcctgt atgatatagt 232441 aagagtgtgc atagcaacta actataattg aacagggtgt ttaaaacatg gaaaaacaat 232501 acagagtatt actttactat aaatatgttc cgattgaaga tccagaggcg tttagagagc 232561 agcatctggc tttttgtaag gagcttggtt tgttaggccg tatccttgtt tcttctgaag 232621 gaattaacgg tacggtatca ggtacggttg aacagactga aaaatatatg gaaacaatga 232681 aagctgatcc tcgctttgcg gacatggtat ttaaaattga tgaagcagaa ggccatgcct 232741 tcaaaaaaat cttcgtccgc cataaaaaag agcttgtaac gcttcgtctt gaagatgatg 232801 tcgatccgaa cgaaacaaca ggccagcatt tgaagcctgc agaattttat gagaagatgc 232861 aggatccaaa cacaattgtc atcgacgcgc gtaacgatta cgagtatgac cttggccatt 232921 tcagaggtgc ggtccgtcct gacatcgaag ccttccgtga attacctgaa tggattgaag 232981 agcacaaaga tatgcttgaa ggcaaaaaga ttttaacgta ctgtacaggc ggcgtgcgct 233041 gtgaaaagtt ctcaggatgg ctggtgaagc aaggctttga agatgtagct cagcttgatg 233101 gcggaatcgt gacatacgga aaagatccag aggtgcaagg caagctttgg gacggccagt 233161 gctacgtatt tgatgaaaga atcagcgtgc ctgtcaaccg tgtcgagcat gtgattgtcg 233221 gcaaggacta ctttacagga gaaccgtgtg agcgttatgt gaactgcgca aatccatctt 233281 gcaataaaaa aatgatatgc acaccggaaa atgagtataa atatatgcgc agctgcagcc 233341 acgaatgccg cacgaaccca agaaacctgt atgtgaaaga gcataatatg acagaagaag 233401 aagtaaacgc aagactggca gcgattgaaa cagaagatca cgctgctgct gaataaaaaa 233461 agaacacctc gtattgaggt gttctttttt tctatatgct ttcagtttgg ctgtttgcgg 233521 aaacccattc tttttggcgg aaggcctttt cccattttga taccacgata caggcgatcg 233581 catgtcccgg tacgttcacg cctgttctcg ccatgtccat gacgcggtca acacccgcga 233641 taatggcaac gccttcagcc ggcagtccta cagcattggc agtcgccaga agaactacaa 233701 gcgatcctga gggtacagct gcaatgcctt tactggtcat cacaagcaca agcatcatga 233761 gcagctgctg ggacaatgtc atgtctactt gaaaggcctg tgcgagaaag atacaagaaa 233821 ccgataaata taagctggag ccgtcacagt tcaatgacaa gccggaggga acgacaaatg 233881 ataccactcg tttgggacag ccgtatttct ccattctatc catcagctga gggagaatgg 233941 tttcagtgct tgtggtggaa aatgcaatta aaaacagatc ccatatcatt ttcaatactt 234001 cgaaatactt aatctgaaag atgagaccga caagcggaaa gaggacaaag aggatcagga 234061 acaggccaag gaatacggtg ccaaccagct taaacatagg gaggaggagt tcaatgccat 234121 attggcctac agaagcagcc atcagggcta acacgccgat aggagcagtg accatgacga 234181 tttgcgtgag cttgaacata atctgagctg tagattcaaa aaacttcatt actggttcag 234241 aagctttgcc gataccagct gcggcgacac caaataaaat ggcgaagaaa ataacggcaa 234301 gcaaatcatt tctggccatg acatcaataa tgtttgtagg gataatatcc aggatcattt 234361 gcttgaaatc aacaactttg tctgtgtagc cggaaagttc atgaatatct ttttttgcca 234421 aatgggagag gtcaagcccg acacctggtt ttaagacatt cgctaataaa agtccaagcc 234481 ctaataccaa cgttgtaatc acttcgaacc aaatgatcgt cttgatgccg agactgccca 234541 tttttttcat gcttccgctt cctgcggctc caatgacaat ggtagaaaat acaatcggca 234601 caacaatcat tttaatcagg cggataaatc catctccgac aggcctcagt gccatcccga 234661 aatcaggaaa aaagtggccg atcaccgcgc cgacagccaa agcgattaaa atttgaaacg 234721 cgattaattt tttcaaatga atcccccttt agaacgatag aatgtaggca tattcatatc 234781 attcgtgatt caaatgcaaa cacctttttt caagttattt tattttgaca gcgctttcat 234841 tatgttggcg aaaaagtccc ccgcagcagg ggggactttt ttacttcatt tgaatgtgct 234901 ttagatcttc ttcagaggta tttgtgaaaa taaccggtgt tatggctgaa gcggcatgct 234961 gcttgatgta attgagatca aaggtgagaa gcagttcgcc ttgtttgacg gcttgtccgc 235021 ttgtgacatg tgcttcaaag ccttccccat tcagtttgac ggtatcgatg ccgacatgaa 235081 tcaggatttc agtgccgccg gcgctcataa agccgatggc gtgttttgtc ggaaaaatcg 235141 agacgatctc gccgtccgca ggtgcaacga cttttccttc tgatggtata atcgcaaatc 235201 cctcgcccat cattttttct gaaaagacct gatcaggcac atcccctaaa gagactgttt 235261 ctcctttaat cggataaata aaggtctcat cggaatcggg cttcagcggt ttgtcagtta 235321 ccgtgtccag cgcggcggcg gtggcaggga cgcctccggc catgattgtt ttgatgtcgt 235381 cttttaaggc atcggacttg gttccgaata ttgcctggaa gttgttgttg acctccagca 235441 cacctactgc accaagccgt tttaattcat ccttgcagac ttggcttggc tgatgaacgg 235501 tcacacgaag ccttgtgata catgcatcca ggttagcgat attttgctgt ccgcccaagg 235561 cctgcagcac gtgaaaggca agctggtctt ttgcaactgg agctttctcc tcattctgac 235621 cgtcttcatc tgtctcacgg ccgggcgttt tcaaattcca tttcagaatc gcaaatcgga 235681 acaaataata ataaatgaaa gcaaacacga tcccgacagg aatgacaacc cagccgtttg 235741 tagacagtcc gtagttcaag acgtagtcaa ttcctccgcc tgagaacgta tagccgtggc 235801 ggacatggaa taaatcacaa acgacaaaga tgacgccggc aagaatagag ttaatcaaat 235861 agagcacggg cgcaacgaac aagaaagaaa actcaaccgg ttctgtaatt ccggtcagca 235921 tagatgtgag cgccgcagaa atcatcacgc cggagatcat ttttttcttt tccggacgcg 235981 cggtatggat aatggcaaga gcaacggccg gcagacagaa aatcatgtaa gggaaatccc 236041 ccatcataaa gcgcccggct gtcgggtctc ccgcgaaaaa ccttgtcagg tcgccggtta 236101 cggtgttgcc tgttgatggg tctgtgtatt ctcccatcat aaaatagaaa ggcgtataaa 236161 aaatatgatg caggccaaaa ggaatcagca aacgatagat cgttgcataa aagaacaggc 236221 cgactgttga atcggcaatt aaactgctgg ctgcgttaat tccgttttgg atcagcggcc 236281 aaacgaatga gaaaatgacg ccgatcacca atgaactgac ggaagtaatg atcgggacaa 236341 agcgttttcc agagaaaaat ccaaggaccg gatgcagctc gattgatgaa aatcgcttat 236401 ataaataggc ggcgagaagc ccgataatga ttcctccgaa aacccccata tcaatcaggt 236461 gctcggctcc ttcatacgga ggctgaaggc cgagtaattt tcccatattg tcgagggtga 236521 cggttaaaat taagtatccg atgacagcgg caagtccggc tacaccttct ccgccggcta 236581 atccgatcgc gacccccacg gcgaaaatca gcggaaggtt atcgaataca acgccgcccg 236641 catcctttat aatagggatg ttcagtaaat ccttgtctcc gaaacggagc aaaagacctg 236701 ctgccggcag gacggcaacc ggagtcatca acgcgcggcc aagctgctgc agaatttgaa 236761 atgccttttt aaacatgaca gtctcctttt attgtgttat gagaatgatg cactctttaa 236821 tttttgagct gctttataat cggcgataac ggttacatga ttgtgttttt gaagaatgga 236881 ggctggtaca tctgtcgtga caggaccttc agccatcttt tgaatggcgt ctgctttttc 236941 ctcgccgctt gctaaaagca caatatgttt gctgaattcc atgatggttt taatgcccat 237001 tgaaatcgcg agtctcggaa ccagcaccgg atcgccgccg aagaatctgg catttgcctg 237061 tatcgtgctt tccgagagct tcacaacacg tgtccggtct tcaaaatcag atcccggttc 237121 attaaaaccg atatggccat tggcgccgat gccgagaatt tggacatcaa tgcctcccgc 237181 ctggcggatg agatcctcgt atactttgca tgccgcctca agctgcggat tgtctccttg 237241 cgggatatga atatgatcag gctgcatatt gatatgctga aaaagatgct catgcataaa 237301 atggttataa ctttgcggat gagatggaga gagaccagca tattcatcca aattaaatgt 237361 agtaaccttt gaaaaatcaa tttcgcctgc ctgatagtct gaaatcaact gcttatacaa 237421 gccgaccggt gtgcttcctg ttgccaggcc gagaacggca tctttcttag cttgtatttg 237481 ttctttaata atggcagcgc ttaacttaca gagttcttcg tagtgctcgg cgatcagaat 237541 cttcatgtga caccccctca aagagataga caagcaccat atttgttatg accaatttat 237601 gatacttgtc attacgaatt tagcaccgcc cttatcaaac tgtcaatatt aatttctgaa 237661 aatttgttat aaaagaagga tacaaatctt tcatattggg agggcaaatg gtattatggt 237721 ctcaatgaaa aagaacggat tgcatacaga atggggagaa tgaaatgaca gctttatatt 237781 ctgttatcaa gtttaaaatc attgagttaa ttaaatcggg caaatatcag gcgaatgatc 237841 agctgccgac ggagagtgag ttttgcgaac aatatgatgt cagcagaaca actgtgagac 237901 tggctctgca gcagctagag cttgagggat atattaaaag aattcaagga aaagggacat 237961 ttgtatcggc ggccaaaata caaacgccga ttccgcataa gattacgagc tttgcagaac 238021 aaatgagagg acttcgttct gaatcaaaag tgcttgagct tgtggtgatt cctgccgatc 238081 attccatcgc cgagcttttg aaaatgaaag agaatgaacc tgtcaacaag cttgtcagag 238141 tcagatacgc cgagggggaa cctttgcagt atcatacctc atatattccc tggaaggcgg 238201 caccggggct ggcgcaggag gaatgcaccg gctcgctgtt tgaattgtta aggacaaaat 238261 acaatattga aatcagcagg ggcacggaat cgatcgaacc gattttaacg gatgaaacga 238321 tcagcggaca cttattaacc aatgtcggag cgcctgcgtt tttatcagaa tcccttacct 238381 atgataaaaa tgaagaagtg gtggaatatg cgcaaattat tacacgggga gaccgaacga 238441 aattcaccgt agaacagtca tatcattcat aaagcaatgt gttttaagaa gggaatggtg 238501 gttctatgtt tttatttacg aatggaaaag tgctgtgggg agcagtgatt gctgcattca 238561 tcctttcaat tgtattttac ccttttctgc cgacgcagat gccgattcat tatgatgttg 238621 cgaacagtcc ggatctgacg gttaacaagc tggcggggac tgtgatgctg cctgttttga 238681 tggtggtgtt tgcatgggcg cggaagatca attggcaatt tgtattcgca gtgtatattt 238741 tgctgatttg ccacattgtc gtcctttgtt tagcgctcta aatcaaacag ccagaataaa 238801 actggctgtt ttctttaatt tcagcttcat ctgacaatga atgtggtgta taatagctga 238861 tgatcctaaa gaatattctg aaatttatag gtgtgaagcg gcgtattatt aaaggaaagg 238921 ctgtatactt tttgcagctt taaaaagact gaatatttaa acaattatgt gaaaggtgtg 238981 ctgattagat tgaataagct tattgaacga gaaaaaactg tatattataa ggaaaagccc 239041 gacccgtctt ccttggggtt tggacaatat tttacagatt atatgtttgt gatggactac 239101 gaagagggga ttggatggca tcatccgaga attgcgccgt acgcaccgct tacgcttgat 239161 ccgtcttcat ctgtttttca ttacggccag gctgtttttg aaggattaaa agcatacaga 239221 acagacgacg gcagggtgct gctgttccgt ccggatcaaa atatcaaacg gctgaacaga 239281 tcgtgtgagc gcatgagcat gcccccttta gacgaagagc tggtgcttga ggcattgacg 239341 caattagttg agctggagaa agattgggtt ccaaaggaaa aaggaacgtc actgtatatt 239401 cgtccttttg tcattgccac agaaccgagt ctcggtgtga aggcatccag gagctataca 239461 tttatgatcg tgctttcgcc tgtcggctcc tattatggcg acgatcagct gaagccggtt 239521 agaatctatg tcgaagatga gtatgtgagg gcggtcaacg gaggagtcgg gtttgcaaaa 239581 acggctggaa actatgccgc cagtcttcag gcacagcgga aagcgaatga actgggctat 239641 gaccaggtac tgtggctgga cgccatcgaa aagaaatatg tggaagaagt agggagcatg 239701 aacatctttt tcgtcataaa cggggaagct gtcacacctg ctttaagcgg aagcatttta 239761 agcggggtta cacgtgcgtc tgcgattgaa ttgattcgaa gctggggcat tccggttcgt 239821 gaagagagaa tatcgattga tgaggtgtat gcggcctctg cacgcggaga attgacagag 239881 gtctttggca caggcacggc agcagtcgtt acgcctgtcg gtgaactcaa catccatgga 239941 aaaacggtga ttgtaggcga cgggcaaatc ggggacctct cgaaaaagct gtatgaaacg 240001 ataacagata ttcagcttgg caaggtaaaa ggcccgttta actggacagt ggaagtgtga 240061 aaatcgaaaa agaacctgcc cggaggcagg ttctttttat tttgaatgag tcatatcagc 240121 agccggctgg cttttgcggt tttttacata atatattgca tagcaaatgg ccataaatgg 240181 aacgccgcaa tagagtgcga ttctttgatt cggatcaaag gcaatgccaa cgacggaagc 240241 caggcataac aggaacgcag caatcggcac gaacggatac aaaggggttc tgtatttcaa 240301 atcagtaacc ttgtttcccg cttcgatata acgttttctg aacatgaatt gagaagcagc 240361 gattcccatc cacacgacaa cgacggcaaa accggaaatc gacacgagca caacgtatac 240421 agtgtctggc gcaaatacgc tggacagcaa cgacagaatg ccgccgatca tgctgaacac 240481 cagcgcgtta aaaggggttc cttttgacgt cagctttgca aatgtcggat gaagcgtttt 240541 ttcttttgat aaagaccaca gcatccggga agaagcgtag agtccggaat tagccgctga 240601 caggatcgct gtcaggataa caaagttcat gatatcggct gcgtatggta caccgactct 240661 gtcaaagaca gcgacaaacg ggcttttgat gacacctgca tcttgaatcg gaatcagccc 240721 tgacagcaca aaaattgttc cgacaaagaa gagcgagaga cgccagaccg ttgtttttat 240781 cgcttttggt atcgtcttgt caggatcaac gctttcaccg gctgcgattc cgattagttc 240841 cgttcccgaa aaggcaaaat tgacggacag catcgtcatc aaaatcggga caaatccatt 240901 gggaaaaagc ccgccttccg ccgtgaagtt ggacagcatc ggagcggctt ctccgccttt 240961 gatcgggatg atgccgaaca tggcagagcc gcctaaaaga ataaataata caatggctaa 241021 tactttgatg ctggaaaacc aaaattctga ttcagcgaaa aacttgaccg aaaatgcgtt 241081 aagcaagaag atgaacagcg caaagacggc actccacatc caaaccgatg tatgggggaa 241141 ccagcgctgc attaacaggc cggctgctgt gaattctgat cccaatgcca cggtccatgt 241201 cagccaatac agccaagcga ccgtaaatcc ggtgcccggc cctatgtatt tggctgcata 241261 ggtgtgaaag gcgccggtca caggcatggc gactgacagc tcaccgaggc atagcatgac 241321 cagatagacg atgccggccc cgactaagta ggcgagtatc gttccggccg ggcctgcttg 241381 ctgaatggta taacctgagc ttaaaaacag cccggttccg atgacacctc ccaaggaaag 241441 cataaagagg tgccggcttt tcatacttct ctgaaaggtt gtctcattct tgttgtgggc 241501 agagttcatc tttttccaac tttctatcag cgatttattt ccttcctaat aaaaaatctc 241561 atgtcagaaa gtgacacgag actccggcga accggcttta agttagaata tacaaactat 241621 tccgataagt caagttgttt ttaaagagcg ggcccaagcc gcaatttctt gaatattttc 241681 gggttttgtc cggcagcagc cgccaatcag cctcgctcct ttttcatgcc aggtgcgggc 241741 gctcgccccg taagattctg cgcatgctgc gccgttccac gtttttgttt ccggatcata 241801 ttgctcacct gaattcgggt agacaatgat cggttttgac gtgttctttt ttaactcctc 241861 tatcaaggaa gggatatgct gaagcggcgt gcagttgatg ccgagtgctg caatttggcg 241921 gtgttcatca agccacgatg cgcagtcagc tgcaggtgtt ccgtcactga tatgcaagcc 241981 gtctttagca ctgaagctga tccatgcata cgtttcagga aattccttca acagccgaac 242041 aatcgctttg gcttcagtca gacacggaat cgtttcgcat gccaatacat cagctccggc 242101 ttcaatcagc gccttcatcc gggggcgatg aaattcaatc agttcatctt ctgatattgc 242161 gtagttgccg cgatactcag acccgtctgc aagataagcg ccataagggc ctatagaagc 242221 cgcaatgatc ggttttggcc gattcaaacg gttctcttca agcgaccaaa attcatcacg 242281 tgcttcagct gcgatgctga cggacaactc gatgagccgg cgtgcttccg cttcgctcag 242341 cccgcgtgcg gcaaagcctt caaatgtaga ctgatagctg gcggtgattg cacaatcggc 242401 gcctgccgca aaataatcag tatgaacttg tttaatcagc tccggctctt ccatcaggat 242461 ttttgccgac cacagactgt cattcaaatt acagcccttg cgttcaagct cggtcgccat 242521 ggcgccgtct agcacaataa gcgggtatgt atctaatatg tgttggatag gattcataga 242581 atgtaccgat gccttctttc agattttttt gaaaaagata tgaaaatcgt aatggaggct 242641 tacgtgtttg tcaataaacg caaaaagaga aaggtgttca gcccatatgt ctgaacaccc 242701 ttttcttatg atatttgttt gttgtgcgtg tcagtctttg tgtctgaaac cggccagcac 242761 tcaatgccat tatggttttt gagcacatct ttataaaaga ccggatcctt gcctgctttt 242821 ttctggcgtg tatagtcttt cagcgccgta aaaacgacct ttgatagtaa gaaaatcgcg 242881 attaaattca cgatgaccat caaacccatg aacaaatcag caagatccca gacgagctgg 242941 actttggcaa cacagccaaa cacgatcatt gccagcacgc cgatacggta gacaaaaatc 243001 agttttttgc ttttgttcaa aaagccgata ttggtttcgc cataataata gtttccaatt 243061 agagcacaga atccgaataa caaaatcaga atcgcgagaa agcctgatgc ccatgatccg 243121 acatgggagc tgagggaggc ttgtgtcaag gcgattccgc tcagacccgg agtatgatag 243181 gcatccgaaa acagaatgat aaaagcggtg cttgtacaaa tgaccagtgt atctgtcagt 243241 acaccaaaag cttggatcag cccctgtttg acgggatggc ttgttgtggc ggtggcagcg 243301 gcatttggtg cgcttcccat tcccgcttcg tttgaaaaga ttccccgtct gacgccttgc 243361 atgagtgccg cgcccaaagc cccgccggcg gcctggtcaa aaccaaacgc atttttcacg 243421 attagcgcaa gcacacctgg cagctgcgta atgttggaga aaatgacgaa aaacgcaact 243481 ccgatataca ggacagccaa tacgacgaca atggattcag ccagctttgc aatgcgcttg 243541 actccgccaa aaataatcgt gccgaataca gcaattaaaa tgagtcccaa tgtcaggcgg 243601 tttgtgccaa acgcgttttc aaaggcaagg ctgactgtat tggattgaac cgagttgaag 243661 acgataccga acgataaggt gattaacaca gcgaacagcg cgcccatcca ccttttgttc 243721 agcccttttt ccatgtaata cgccggcccg ccgcggaagc cgtttacatc ttttacttta 243781 taaatctgag ccagtgtgct ttccacaaag ctggatgctg atccgataat ggcgataatc 243841 cacatccaga agattgcacc gggcccgccg agtgcaatgg cgatagcaat gcccgtaata 243901 tttcccgttc cgacacgggc cgccatgctg atgcaaaagg cttgaaacgg agaaatgctg 243961 ttttttgacc gggaagcagc accttctctt aataccctga ccatttcttt cagcatgcga 244021 acctgtaaaa acttaagcct gaacgtaaaa tagattccaa aagaaaggag caaaacaatt 244081 aatagctttg accacaaaag atcatttgca ataccgacga tatgttctag gatttgctgc 244141 atagaatcac ctcttttttc atgtttaaaa aatgctgagc tcccattcct gcgccatatg 244201 cttcagcagc ataccgccag tgaggctgtt gccgtattca tcaatggcag gcccgtaaat 244261 gccgatgccg catccggatt gaaaaggctg ttctcttctg gcgcttggag gcaccagcgc 244321 catgatgccg ccggagacgc cgcttttggc cggcacgccg acaaacgccg catatttgcc 244381 tgaagcgttg tacatgccgc acgtcagcat taatgccttg gccaattttg ccacatcttt 244441 tggaatcacc tgctcgtgtc gaatcggatg atacccgtca tgagcaagga tcaggccgat 244501 caacgcaata tcttctgtag tgctctccat agcgcattgc ttcaagtaca cctcaagtgt 244561 ttcttctact tcagcttcta aaaagtttgt ttcttttaaa tagtaggcca gcgctctgtt 244621 gcggtgggcg gtttcccatt cagaacggaa tacttcttca tgaattcttg gccgttttcc 244681 tatcaaagtt tccatcaccg agtaaagaaa ctcgagcttt tcgtatgcag attctccggg 244741 aaggatcgaa gcgatggtga gggcacccgc gttgatcatg ggattgaagg gctttcccgg 244801 cttgttgatt tcgagccgaa tgattgaatt aaaggcgtca cctgtcggct cgacatctac 244861 gcggtcaagc acatagggaa tgccgcggct catgcaggcg gcaataaagc taatcacttt 244921 tgaaatgctt tgcatggtaa aagagacgtt ccagtcgccg gcgtgtatca tcgttccatc 244981 aggctccaat acacagatgc cgagctgtga atcattgact tttcctaaag cggggatata 245041 gtttgcgctt tgtccattgg cggcaaaagg gcgatagtat tcaacccaat catgaagctg 245101 taacgccggg tttatgtctt tctggtgctc ttttatcaat tctttcatcg aattcctcct 245161 cactgatttt tttcttaaag gactgaggtg tatcaaaacg aaggctaagg gggcgttaaa 245221 cgctttcata atagcggaag gtataattac tgtataatgg agactacaga atcatacaaa 245281 atacgacaaa aacattttga aaataagcag taagatttat aaaaacctca tgttctgggt 245341 caaaagcaat ttgcaggttt tctcccgatt ccccaaaata aaaagcgagg atgtgatcaa 245401 cataaaactg gaacggttta ttgaaaaaga cggatatata ctggccctca tgctgattac 245461 ggtgccgctg gccggtgaac tgaaatttta tcccctcaat gaagaattcc gggtcagctt 245521 tggggcaccg gtttttttct tctttttatc attgttgcgg catgtgcccg ctgtgctgcc 245581 gggttttctg actggagcgg ctgttttcat ctttcgcgtc tttctggaat tatggggcgg 245641 aggacacaat gggctgactc cgattctgta tgatcaagcg tctggctttt tcttttatat 245701 gacttacgcc tgtctgtttt ccatattaaa ggccaatcgt ttccgtgaac ggccgattat 245761 gctcggtttc attgggttta tgattgaagt tgtgtcagat tgtgtcgagc taactgtgca 245821 atttctcatt tttcatacgg ttgtcacgcc tgagaaaatc actgacattg cggtgattgc 245881 gatttctcac acatttattg tgatgagctt ttatagtgtg ctgaagctgt atgaaacaca 245941 atcgagagaa aaacagacaa ggcagcagca cgagcacatg ctgatgatcg tttccaattt 246001 atatgaagaa acggtgcacc taaaaaagac attgaaaacg acagagaaag tgacaaacga 246061 ttcgtatcag ctctatcggg aaatgaaggg caaggatgtt cagctgagcg gcagaatcct 246121 gagactggcc ggagagattc atgaagtgaa aaaggacaac cagcggatat tcgcagggct 246181 ttcaaaactg atttcgaatg agagtttgag agattatatg agggcttctg atttgctgca 246241 gctcgtgatt cgaatgaatg aaaagtacgc tgaagcacta gggaagcaga ttgattttta 246301 ctgctcgatc gagggagagc atgacgaata tcacgtattt atcgtgcttt cgatcattaa 246361 taatctaaca gcaaatgcgg tagaggctat ggatgaagag ggaatggtca gcctgaggct 246421 ccgtaagcca aatgagagta tggtagaatt ccaggtggaa gacaatggcc ccgggatttc 246481 cgagaaaatc ggagacattg tgtttgaccc gggctttact tcaaaatatg acgaatttgg 246541 cacgccttct acgggtatcg gactttccta cgtaaaggaa atcgtgacag agctagaagg 246601 ggatatcacg tttgataatc agcagcgggg agtggtgttt gccatcaggc tgcctgtccg 246661 gcatttgatt cagaaagggt gaaccaaaag ctatgcgttt ttttattgca gatgatgacc 246721 gtgcggtgcg gtcaatttta aggcagatca ttgaggacga agatctcggg gaagctgctg 246781 gtgaagcaga cgacggaagc caagtggaag ggcatatgct gcaatttaag cagattgata 246841 ttttattaat cgatctgtta atgcccggaa gagacggcat tgagacgatt cgtcagatcc 246901 agaatacgta ctccggcaaa atcgtaatga tctctcaagt ggaggcgaag gaaatggtcg 246961 gggaagcgta ctcgctcggc atcgaatatt ttatccataa gccgattaac cgcattgaaa 247021 ttgtcacggt tctccaaaag gtgaaggagc ggatcgagct tgaacactcg attggagcca 247081 ttcagcattc tctaagccgg cttgtcaatc ggactgaacg gaaagcgcgt ccccagcaga 247141 agagtgacag cggtttaaaa gaggcaggaa cattcctgtt gtccgagctg ggcatgatgg 247201 gagaaggcgg cgcacatgat ctcatggcgg tcctgcagta tttagcagaa cacgagcaat 247261 ccgagccgca cgaaaaacaa agcccttcgc taaaacaaat attcacccaa gtagcggtac 247321 ggaagctggg gacaggagcc tcacagacgg aagtcaatcg cgaaatgaaa gcctcggagc 247381 agcgtatccg cagagcgatt attcattcgc tgcaccattt tgcttcactg ggcacaactg 247441 atttttcgaa tccaaaattt gaaacctatg catcgaaatt ctttgatttt ccggttgtca 247501 gccagaaaat gaaagaactc caatccaagg atgcaaaacc ccttgcacct gctagaataa 247561 atatgaaaaa attcatccac gtgttttttt tggaagcaaa gcttttgcat gagacgatga 247621 aacaaagaag gatataaacc aaacagccgg ctgaccaggc tgtttttttg ctgcgcagaa 247681 tcccggccgg acagtgattt accgcttttt tataaaatat cagaaaataa agatattgac 247741 ttattgttta tttgtcttac aattaaacaa aaggatatat gggaaggagc ggatgtgaaa 247801 gaaaaattaa taaaagcgct tacagataga ggccgtatac acaaataaca ggaggttatg 247861 ttgatgagcc gtatcagaaa agcacccgct ggaattttag gttttccggt tgctcctttt 247921 aacacacaag gaaaactgga ggaagaagct ctttttcaaa acattgagtt tttgctgaat 247981 gagggcttgg aagcgatatt tatcgcttgc gggtctggtg aattccaatc tctcagccag 248041 aaggaatatg agcaaatggt ggaagtcgca gtctcggcag ccggaggaaa ggtgccggtc 248101 tacacggggg tgggcggcaa cctcagcaca gcgcttgatt gggcgcagct gtcggagaaa 248161 aaaggcgccg acggctactt gattctgcct ccgtatttgg tgcatggcga acaggagggg 248221 ctgtaccagt atgcgaaaac gattattgaa agcactgact tgaacgcgat tctttatcag 248281 cgcgataacg cagttctctc tgttgaacag atcaaacgtc tgaccgaatg tgaacagctt 248341 gtcggtgtca aagacggggt aggaaatatg gatttgaata tcaatctcgt ctatacgatc 248401 ggcgaccgct tgggatggct caacggaatg ccgatggctg aagtgacgat gccggcttat 248461 ctgccgatcg ggttccactc ttactcttca gcgatttcaa attatatccc gcatatttcg 248521 cgaatgttct atgatgcatt gaaaaacgga aatgacgagc ttgtgaagga actctatcgg 248581 catgtgattc tgccgatcaa cgacattcgc aaacaacgaa aaggctacgc cgtatccttg 248641 attaaagccg gtatggaaat catgggtttg aatgtaagga atacagccag accgcctgtc 248701 ggcccggttg aaaaagatca ttatcagcaa ttggaagcaa ttttgaagca ggcggctgac 248761 cgttttccga aaaaagccgc gacggtttga ccagaaaaaa cacgaaaggg gcaatgggca 248821 tgtctgtgat cacggaacaa aacacgtacc tcaactttat taacggagag tgggttaagt 248881 ctcaatcagg cgatatggtc aaagtcgaaa accctgccga tgtgaatgat attgtcggat 248941 atgtacagaa ttcaacggct gaagatgtgg aacgtgccgt caccgccgcc aatgaagcca 249001 aaacggcttg gagaaagctg acgggtgccg agcgcggcca atacttatac aaaacagcgg 249061 atatcatgga gcagcgcttg gaggaaatcg ccgcctgtgc aacgcgtgaa atgggtaaaa 249121 cattgccgga agcgaaggga gaaacagccc gggggattgc cattctgcgc tattacgccg 249181 gagagggcat gcgaaaaacg ggtgacgtca ttccgtctac tgacaaagac gcgctcatgt 249241 ttaccacccg tgttccgctc ggtgtggtcg gtgtgatttc tccgtggaac ttcccagtgg 249301 cgattccgat ttggaaaatg gcgccggcat tggtatacgg caataccgtt gtcatcaaac 249361 cggcgacaga aacagctgtg acatgcgcga agatcattgc ctgctttgag gaagcggggc 249421 tcccggcagg ggtcatcaat ttggtgacag gcccgggttc tgttgtcggg caggggcttg 249481 ctgagcatga cggtgtaaac gccgttacgt ttaccggttc aaatcaagtc ggaaaaatca 249541 tcgggcaagc cgctttagcg aggggagcca aatatcagct tgagatgggc ggcaaaaacc 249601 ctgtcatcgt agctgatgac gctgaccttg aagctgcggc agaagctgtc ataacggggg 249661 ccttccgttc aaccggccag aaatgcaccg cgacaagccg tgtcatcgta caaagcggaa 249721 tttacgagcg ctttaaagaa aaactgctcc agcgcacaaa agatattaca atcggagaca 249781 gcttaaaaga ggatgtctgg atgggaccga tagccagcaa gaatcagctt gataactgcc 249841 tgtcatacat tgagaaaggc aaacaggagg gcgcttccct tttaatagga ggagaaaagc 249901 tggagaacgg aaagtatcaa aacggctatt atgttcagcc tgccatcttt gacaatgtga 249961 catctgagat gacaattgcc caggaggaaa ttttcggtcc ggtgatcgcc ttgatcaagg 250021 tggactcgat agaggaggcg ctgaacatcg ccaatgatgt gaagttcggt ttaagtgcat 250081 ccatcttcac ggaaaacatc ggccgaatgc tttctttcat tgatgaaatc gatgccgggc 250141 tggttcggat caatgcagaa agcgcaggtg ttgagctgca ggcgcctttt ggcggcatga 250201 agcagtcgag ctcccactcc cgagaacagg gtgaggcagc gaaggacttt ttcacagcga 250261 tcaaaactgt ttttgtgaag ccgtaatggt gctggaaaga ggcgtgcgtc tctttcccgg 250321 tttatcacaa ccagcatatg attctctact ttgaaaagga gaagatacta tgaaaaaaga 250381 ctttgcgagt gttactccgg cgggcaaaaa aacgtccgtg cgctggttca tcgtgtttat 250441 gctgtttctt gtgacctcta ttaactacgc ggatcgagcg acgctttcca tcaccggaga 250501 ttccgtccag cacgatttgg gattggactc ggtcgccatg ggatatgtct tttctgcctt 250561 tggctgggcc tatgtcatcg gacagcttcc gggcggctgg ctgctggacc gttttggttc 250621 aaagactatc attgcgttaa gcatcttttt ctggtcgttt tttacgttgc tgcaaggggc 250681 gattggcttt ttctccgccg gcacagcgat tatcctgctg tttgcactgc gttttctggt 250741 tggtttatca gaagcgcctt catttcccgg aaacggcaga gttgttgcct catggtttcc 250801 aagctccgag cgcgggacag cttcagcctt ttttaattca gcacaatact tcgcaatcgt 250861 cattttttct cctttaatgg gctggcttac ccactctttc ggctggcatt ccgttttcgt 250921 tgtcatgggt attgcaggca ttcttctggc tgtcatctgg ctaaaaacgg tgtatgaacc 250981 gaaaaaacat ccgaaggtta atgaagctga gcttgcgtac atcgaacagg gcggcgggct 251041 gatttccatg gatgacagta aaagcaaaca agaaacagaa tcgaaatggc cgtatatcaa 251101 acagctgtta acgaaccgca tgctgattgg cgtgtacatc gcgcaatact gtattacgac 251161 tctcacctat ttctttctca catggtttcc ggtatatttg gttcaggccc gcggcatgtc 251221 tattcttgaa gctgggtttg tcgcttccct gccggcgctg tgcggatttg ccggcggcgt 251281 gcttgggggc attgtgtcag acatcttact caaaaaaggc cgttcactga cctttgcaag 251341 aaaagtgcca atcattgccg gcatgctgct gtcttgcagt atgattgtct gtaactacac 251401 agattcagca tggctcgtcg ttgtcattat gtcgctcgcg tttttcggaa aaggcttcgg 251461 cgcattgggt tgggctgtcg tgtcggacac gtctccgaaa gaatgtgcag gattaagcgg 251521 cggtttgttc aacactttcg ggaatattgc ctcaattaca acaccgatta ttatcggata 251581 cattgtcaat gccactggat ctttcaatgg cgcgcttgtg tttgtcggcg ctaacgcgat 251641 tgcggcgatc ctcagctatt tgctgctggt cgggccgatc aaacgggtcg tgttaaagaa 251701 acaagaacaa gaccccgatc aatcgttgcc tgtctaatat ttatgaaagc gctttataaa 251761 gggaggaaaa tgcatgagtt caccgataca agagcaggtt caaaaagaaa aaagatcgaa 251821 tattccctca atttctgaaa tgaaggtgat tcctgttgcg ggacatgaca gcatgctgct 251881 gaatctaagc ggagcacaca gcccgttttt tacccggaat atcgtaatct taacagacag 251941 cagcggaaat cagggagtcg gcgaggtgcc tggcggagag catattcgcc gcacactgga 252001 gctgtcagag ccgcttgttg tcggaaaatc tatcggtgcg taccaggcga tattgcaaac 252061 ggtcagaaag cagtttggcg atcaggacag gggagggcga ggaaaccaga cgtttgattt 252121 gcgcaccact gtgcacgccg tcaccgcact ggaagcggct ttgttggatt tgcttggaaa 252181 gtttcttcag gaaccggtcg cggctttgct gggcgaaggg aagcagcgtg atgaagtaaa 252241 aatgctcggt tacctctttt acatcggcga ccgaaatcgg acgaccttgc cgtatcaaag 252301 cgatgagcag tcagattgtg cgtggttccg tctgcgccat gaggaagcgc tgacgccgga 252361 ggccattgtg cgtcttgccg aatccgcaca ggagcgctat ggctttcagg atttcaaatt 252421 gaaaggcggg gtgctgcggg gagaagagga aatcgaagct gttaccgcat tatcgaaacg 252481 ttttccagag gcaaggatca ctcttgatcc gaacggggca tggtcattag aggaagctat 252541 tgcattatgc aaaggaaagc aagatgtgct cgcgtatgcg gaagatccat gcggggatga 252601 gaatggctac tccgctcgtg aagtaatggc tgaattccgc cgcgcgacag ggcttccgac 252661 tgcgacaaat atgattgcga ctgactggcg ggaaatgggt cacgcgattc agctccacgc 252721 ggtcgatata ccgctggctg atccgcattt ttggacgatg caagggtcgg tgcgggttgc 252781 gcaaatgtgc catgattggg gtttgacatg gggctcgcac tccaacaacc actttgatat 252841 ttcccttgcg atgtttaccc atgtggcagc agcggctccg gggcggatca cggcgattga 252901 tacccattgg atctggcagg acgggcagcg attaacgaaa cagccttttg agatttcttc 252961 tggctgtgtc aaggtgccgg ataagcctgg actaggcgtc gatattgata tggaacaagt 253021 ggaaaaagcg catgagatct atcggaaaat gaatttaggc gcacggaatg atgcgatccc 253081 aatgcagttc ctgatcagca actgggaatt tgaccggaag cgcccgtgtc ttgtgcgata 253141 agtttgattg taaatattgt catatccgct attttgtctt acaattgaac aactgaaggg 253201 agagttgttc gtgtacgaag gtttagagga tttgaaagtc gatacagtca atcggaaaac 253261 attagccaag caggtcatcg aacggattgt ccatttatta tcgagcggac agttgagggc 253321 cggagacaaa ttgccgacag aaatggaact gatggacatt ttgcatgtca gcaggccggt 253381 gctacgggaa gcactcagtt cacttgaaac gctgggcgtc attacgagaa aaacacgagg 253441 gggcacatat ttcaacgata aaatcggcat gcagccattt tccgtcatgc ttgctttggc 253501 cactgataat cttccggcta tcattgaagc gcggatggcg ctagaactcg ggctcgtgac 253561 aattgccgcg gaaaaaatca atgaggaaga gcttcagcgt ttgcagaaga cgatcgacga 253621 tattgccaac agcactgaca atcattatgg tgaagcggat aaagagttcc atcgaattat 253681 tgcgttaagc gccaataacc ccgtcgttga agggatgatt cagtccctgc tgatcaccca 253741 tgcgaaaatt gacagccaaa ttccgtacag ggagagagat gtaacggtcg aatatcacaa 253801 aaaaatctac gacgcccttg ccaaaagaga tccgtacaaa gcacattacc acatgtatga 253861 gcatctgaaa tttgtccgtg acaaaattct aaaaggaatg gatgaaaaat aatggtgagc 253921 aaccgcagtt gaaacgtaag agctgcggtt tttttaaacc aatttagaaa acgcttacta 253981 aaatatgagg agtgattttc atatggcgat gaacctcagg aagaaccaag ccccccttta 254041 catcaaagtg catgaaatag ataacaccgc gattattgta aatgatggag ggctgccaaa 254101 gggcactgtt ttctcatgcg ggctcgtact tgaagaggat gttcctcaag gccataaggt 254161 ggccctcacc gatctcaatc aaggggacga gatcgtgcgt tacggagagg tgatcggatt 254221 tgctgatgag acgatcaaac gcgggagctg gatacgggaa gccctcgtga gaatgcccgc 254281 tcctccggcg ttagacgatc ttcctctcgc aaacagggtg ccgcagccgc ggcccccact 254341 tgaaggatat acatttgaag gataccgaaa tgcggatggc agtgcgggga caaaaaatat 254401 cctcggcatc acgacaagtg ttcaatgtgt tgttggcgtt ttggattatg cagtcaaacg 254461 aataaaagaa gagctgctgc cgaaataccc aaatgtcgat gacgttgtgc cgctgcatca 254521 tcaatacgga tgcggcgtgg cgatcaatgc gcccgacgct gtcattccga tccgcacgat 254581 tcaaaatctt gcgaagcatc cgaacttcgg cggtgaagta atggtaatcg gattgggatg 254641 tgaaaagctc ctcccggaaa gaattgcctc cgaaaatgat gatgacattc tatcgctcca 254701 ggatcaccga ggttttgcgg cgatgatcca atccattttg gaaatggcgg aggaacggtt 254761 aatcaggctg aacagcagaa cccgggtgtc atgccctgtt tcggatctgg ttatcggcct 254821 gcaatgcggc ggcagtgatg cgttttccgg cgtgacggcg aaccctgccg tggggtatgc 254881 ggctgattta ttggttcgcg caggtgcaac ggttttgttt tctgaagtga cagaggtgcg 254941 ggatgccatt catttattaa cgccgcgggc tgtcagtgaa gaggtcggac aatcgctgat 255001 caaagagatg aagtggtatg acagctatct tcggcgggga gacgcagacc gtagcgcaaa 255061 cccgtcacca ggcaataaaa aaggcggatt atccaatgtg gtggaaaaag cgttaggttc 255121 ggtagcgaaa tcaggcacaa gccccatctc cggcgtgctc ggccctggtg aaagagcaaa 255181 gcaaaaaggc ctgctgttcg cggcgacacc ggcaagcgat tttgtgtgcg gcaccctgca 255241 gctggctgcg ggcatgaatt tgcaggtgtt tacgacaggg agaggaacac catatggcct 255301 ggctgctgcg ccggttctga aagtatcgac gcggcattcc ttatcagagc attgggctga 255361 tttaatcgat atcaatgccg gccgaatcgc gacaggagag gccagtatcg aagacgtagg 255421 ctgggaaatc ttcaggacga ttttggatgt ggcaagcggc cgcaaacaaa cgtgggcaga 255481 ccgttggggt cttcataatg atttgtgctt gtttaatcct gctccagtga cttgattcat 255541 gtttttatag cggaaagatg gaatatgctg taaaatgaaa atcagcgtat aggaaacgga 255601 ggggttacag catggcattc attagattcc gagtgacacg aattcaatag tgaacaactc 255661 tcgcctgaat gcgagagaat cgggatgaat ccgcctatgt atgagccctt atatggttat 255721 caaaaaagag ggtggcgtgc ctgccctttt ttgtgccttc aagcatccct tctctctact 255781 gcaggccgga gcatgagaaa ggggaaatgg gatgacaaac cttaacgaaa aacagcttat 255841 cactgagatt gtcgggcttg cacgcagcca aggtttgacg gttcattctg agaacgcgca 255901 attgaatgaa accggaatgg actttcaagt tgtatttgcc aaggacgaca caggtatgcc 255961 atgggtgctg cgaaaaccgc ggcgaagtga tgttgtggaa agagcatctg cagaaggcat 256021 aacgcttgcc tttctccgcg cgaatctgac tgctgatgtg ccggattgga gaattcatac 256081 accggaattg atcgcttacc ccatgttaaa aggaacgccg gctgctggaa ttgacttgga 256141 acaaaagcaa tatgtatgga atatggatca tcagccgccg tcagacgact ttgtccgcac 256201 acttgccgac atactggctg aattacatgg cacggatcaa atatctgctg ggcaatccgg 256261 aatagaagtg ataaggccag aagatttcag gcaaatgaca gcagactcta tggttgatgt 256321 gaagaataag cttggcgtat ctacgacgct ttgggaaaga tggcaaaagt gggtagatga 256381 tgatgcatac tggccgggtt tctcttcttt gatacacggc gatctccacc cgccgcatat 256441 ccttatcgat caaaatggac gtgtcacagg acttctggat tggacagaag cgaaggttgc 256501 tgacccagcc aaggattttg ttctttatca aaccattttc ggagaaaaag aaactgcccg 256561 tttgcttgaa tactatgatc aagcaggcgg ccgaatatgg gcaaaaatgc aggaacacat 256621 ctcagagatg caggcggcgt atccggtgga aatcgccaag ctagctctgc aaacacagca 256681 ggaggaacac atcaatatgg cgctggaagc acttggtgta acatcggatt aagaattgac 256741 ttcgtttcat gaaccgagta ttataaactc tacaaataat agaacggatt aacaatcgtg 256801 aggaagagca agtacgcatc agaatggagg ttcagagagt cggtggcagg tgtgaaccga 256861 tcctcccctg atgccgaatg ggcttctgaa ttgctttgct gaacggatag taggcgatgc 256921 cgggtttctc tccccgttac caagagagga gtatcgaaac ataggttttc tgtacttaga 256981 gtgaacggct gtatagctgt taataaaggt ggtaccgcga gaccctcgtc ctttgcatag 257041 gacgggggtt ttttgtgttt cttaaaggag gtgacggcca atgtacgatg gctggtggtg 257101 gcatagcaga tgagttagaa aggaggatat caaatggtca ttgcaactga tgatcttgag 257161 gtcgcatgtc ctaaatgtga aagagcggga gaaatcgaag gaacaccttg cccggcctgc 257221 agcggaaaag gtgttattct gactgctcaa ggatatacgc ttctcgattt tatccaaaag 257281 catttgaata agtaaaggag aaaagctgag ctgagatgag agcagaagag cagagtaaga 257341 ttcgtgaggc cgcagcaggt acgatttttt tgctgatcgg aacagtttgt tttgcgtcta 257401 aatcgatttg gataaaatgg gcataccaaa tgggtgctga gccagatgcc gtgctgctat 257461 acaggcagct gctggctgtt ccgctgtttt ggctgatttt tttaatatac cgtcctccaa 257521 tgccagacgg taagaaaaaa ggagacctat ggaaggcttg tggcgcggga gtgttttgtt 257581 tttttctgtc tcccttgctt gattttatcg ggctgaacca tgtatccgca atggttgaac 257641 gtatattgct gatgagctat ccgttgtttg tgtttggatt caccgcgtgt cgtgaccgga 257701 aaatgtcctc aattcaggac cttttcgcag ttctggcggt catgtttggg cttttcttgg 257761 cgctgggcgg ctggaatgct gagcttttcc aggcgaatat gattggagct gtattcattt 257821 tgttatcttc ggccgtctat gctggttatc ttgtcctttc cgggcatctc gtccatcaaa 257881 tcggagggat ccgtctcaat gcatacggga tgacagctgc tggagctgcc atgatgcttt 257941 acacagggat aaaatcggcg gctggcatga atacgccaat ggcagcatat ccgctttcta 258001 tgtatggttt gttcgcagta attgcagtcg ttaccacagt gattccattt gtgctaatgc 258061 ttgagggcat aaaacgaatc ggggcacagc gagccgccgc catttcaatg gcagggccta 258121 tcctgacgat tttctatgga gctttatttc tcggtgaacg gctcgggctc attcaagtca 258181 ttggatgcgg tggcgtattt tttgtcatta cgggcatgga atacaggaag ctgaaaacag 258241 gaaaaaaaga ataattttta taaaacacac acgtttttca attacaataa gtgtaattac 258301 gtgtgtgttt tttgattttg taaaggttag gtgaggagat gcagcgcata ttgcttgtag 258361 aagacgacca ctcaatcagt gaaatggtgg atcattattt aacaaaagaa ggctttggaa 258421 ttgtgcatgc tttcgacgga gaagagggca tccggctgtt tcagcagggt tcatacgatt 258481 tggtcctcct tgatatcatg ctcccgaagc tgaacggcat ggattttctg aaaatcatcc 258541 gggaaaaaag caatataccg gtcttaatga tttcggcaaa agatggagat gtggacaagg 258601 cattgggact gggctttggg gcggatgatt atatcgccaa accgttttcg atgattgagc 258661 tgacagcccg agtaaaagcc gcgatacggc gggcgacgca atattcggca gaggagccgg 258721 ctgtgaataa ggtgatccgg attcaccagc ttgcgataga tatagacaat gtttccgttt 258781 tgaaaaacgg agagccgctc cagctgacgt caacagaatg gcagctgctg tgcttatttg 258841 catcaaatcc taaaaaagtg tttacgaaag aacaaatcta ccgttccgtt tggaatgaag 258901 agtactttga tgatcagaac atcattaacg tacatatgcg gcggctcaga gaaaagattg 258961 aggatgaccc ctcctcccct caatatatta aaacgttatg gggcatcggt tataaattag 259021 gagagtttta gaatgacagt gctatgggtg gccgctgtca tcgctctggc gtgtctgaat 259081 gtgattcaat tcataatgaa aaagaagcgg gacgggaatc tggcttacac ggctgaccag 259141 cttagctaca tgctcagccg ggattcggca ggacaaattt tgcttcctac agacgatcat 259201 gcgctcaaag acttgcttgt taacatcaat cttatcgttg agaatcgtca gcagatcagc 259261 gcccaatttg ccaaaacaga gcaatccatg aagcggatgc tgaccaatat gtcgcacgac 259321 ctgaaaacgc cgttaacggt cattctcggt tatattgaag ccattcaaag tgacccgaac 259381 atgccggacg aagagcggga aagattgctg gggaagctcc gccagaaaac aaatgaactt 259441 attcagatga tcaattcctt ttttgattta gcgaaattag aatctgaaga taaagagatc 259501 ccgatcacca aagtacatat gaacgacata tgcaaacgaa atatcctgca ctattatgac 259561 gctgttcagt caaaaggctt tcaagcagcc atcgatatcc ccgatacgcc ggtgtatgcg 259621 caggcgaatg aagaggctct ggacagaatc ctgcaaaacc tattgtccaa tgcgattcaa 259681 tatggcgcgg ccggcaagtt aatcgggctg acgctgtctt atgatgagag gaacatcgcc 259741 atcaccgtat gggatcgcgg aaaagggatt agtgaaaccg atcagcagcg ggtgtttgag 259801 aggctgtaca cactggaaga atccagaaat aaagcatttc aaggaagcgg cttgggttta 259861 accatcacaa aacggcttac agaaaaaatg ggaggcatca tatccgtcca aagcaagccg 259921 tacgaacgga ctgcatttac gatcacattg aaacgcatga catattaatc gtaagaattt 259981 cttaaggttt gagaaataaa aatgacaggg ctcgccgcta caatagaaaa caggaaaaga 260041 gagggaagga gaaacaaagt tgacttatat cgtacaaaca aacgggctga ccaaaacata 260101 tcagggcaaa gaggtcgtat ccaatgtcag catgcatatt aaaaaaggtg aaatctatgg 260161 ctttctcggc ccgaacggcg cggggaaaac aaccattatg aaaatgctga cgagccttgt 260221 caaaccgaca agcggtgaaa tcatcatcct tgggaacaag ttcacccaca cgtcatatga 260281 ggtgctgggg aacatcggca gcatgattga atatccgatt ttttatgaaa acctgacagc 260341 tgaagaaaat ttagatctgc attgtgaata tatgggatac cacaataaaa aagccataca 260401 agaagtgctg gatatggtga atttaaaaca aatcgacaaa aaacccgtca aaaccttttc 260461 cctcgggatg aagcagcgcc ttggaattgc gcgtgccatc ctcacgaagc cggacctgct 260521 tattctggat gagccggtga atggtcttga ccctctcggc attaaaaaga tcaggcaatt 260581 gtttcaagtg ctgagcaaag agtacgggat gacgctgctg atctcaagcc acctgctggg 260641 tgaaatcgaa caaatcgcgg acacaatcgg cgtcattcgg gacggcaggc tgcttgaaga 260701 ggtatcaatg gaggatgtca ggggccagaa cactgaatac atcgagcttg tcacgccgaa 260761 tcagacaagg gcctgctttg tgctggagaa agagctgcaa ttaaccaact ttaaaatatt 260821 aaatgagaaa acgattcgaa tttacgaggc tgaagcctct caggctgcca tatccaaagc 260881 attgatttta aatgatgtag acattgaatc aatgaacaaa aagtatacgt cgctggagga 260941 ttattttatc aaattgatca acggcaatag catcagtgcg taaaggagga gagacacgtt 261001 gatgaatttg atcagaatcg aattaagaaa aatgaaaatg ggctggtata tcagaggtgc 261061 cctcattgcc aacgtgatca ttatgggttt tatgtggctg atcagttatt ccgaaaaagc 261121 cgatggcggg gtttcgttcc aaagtacgga tgaagcattc ctcatcatcg gcaccttcgt 261181 cagagcggta tttatcgtat ttggcgctgt gctgatcgta aaattggtga tttcggaata 261241 taaaaacaaa accattcttg tgatgttcac gtacccgatc agccgtaaaa agctgctcac 261301 cgctaagctc atgatcgcgg gcggactgac gtttatcacg attttacttt caaatatact 261361 catagccgcc ggtttctttt ggctgaactc gatctgccat ttcataccgg gagagcttac 261421 ttccgagatc atttctcaac aggcggtcaa aatggcggtt ttcgcttttg gcgccgctgg 261481 aaccagttta gttcccatct tttttgggat gcgtagacac tcggttccgg cgaccatcat 261541 ttcatctgta gtaattgtga tgctcatcag ctcaacaagt ccgggcttct cgatttcatc 261601 tgttgtgtat atcccgttat cgttagcggc attcggtttg ttcttttcct acatggcgat 261661 caggaatgcg gacaagcagg atgcgtaaac aaaggcgccc aatatgtata aaaggccgat 261721 gctgtcagca ccggcctttc cattatgagt ctgttcttgt ttcaagataa tgcttcttgc 261781 caatctcttt gctcatcata tagaaatgga agcaatattc accgattgcc atgacgatcg 261841 cgccgaataa agccgccaat gcaacttcac cgccagtcat ccccatagaa agcggcatgc 261901 ccatcagcca gatcacgaga aaggccaaac caaaatcagc caaagttgca atcatattat 261961 tccatttcgg caatacataa agatcgccca gcaaataaga aataacccct aacacaatcg 262021 tcattagcag cgtatcacca aacgtgaaac caaagcccag accaagcacc agatacaaca 262081 caataatcgt cataatacct ttaatagcga gcgctttcac atgtgtcatt acaattcctc 262141 cttttgtcat ttgatttgtt atgtataatt cctcaaatgt aaaaagttaa accttatttc 262201 ttttcggagg cgggtgcaaa tctgctgggg agaggtcaat gatgtgaatc caggaattga 262261 ggctgcggcg cttcgacagc ggaaacgtga agcttgtact gcaccggacg ctgctttgat 262321 gcccaacagc ccattatgtt tgctgttttt agatgaataa atttaaaaac ttctcctgtc 262381 cctccgtcat cacttctgaa gtaatgaaat atgatgaaaa gagatcaagg ggaggtgacg 262441 tgatggcggt cgtgagagca acgagtgcgg atgtcgattt gatggcaagg ctgctcagag 262501 cggaagcgga aggcgaaggc aagcagggga tgctgcttgt cggcaacgtt ggaattaatc 262561 ggctgcgggc gaattgctca gattttaaag gcctccgcac catcaggcag atgatttatc 262621 agccacacgc gtttgaggct gtgactcatg gatattttta tcaaagggcg cgagatagcg 262681 agcgtgccct tgcacgccgg tcgattaatg gtgaaaggcg ctggcctgca aaatttagtt 262741 tatggtactt caggccgcag ggggactgtc cagcccagtg gtataaccag ccgtttgtgg 262801 ccagatttaa gtcacactgc ttttatcagc cgacggcgga gacgtgtgaa aatgtatata 262861 acacatttta gagacaggac accgttcaaa ttgaacggtg tttttctttg aaaagatgca 262921 atgcaaaata ttcctgtgag ataatcaaag aaaaaagagc tgacggagat gacagaatgg 262981 caacaattga cctgcaaaag aaaagtgtaa agatcgtact ggagaaaaag cagttaacga 263041 aggtgacggc tcgtgttgga ctggttcttg atattacggg atcgatgaga ccgctctaca 263101 aaaacgggac ggttcaaaat gtggtggagc ggattttggc agtggctgat cagtttgatg 263161 ataacggttt gctggatgta tgggtgtatg ataatgaatt ttcccgatta aagccagttt 263221 cagaaaagga tttttcgggc tatgtcgatc gtgaaatttt aaataatgac cgcttgcata 263281 aattcggcag aaatgatgag ccgccagtca tgaaggacgt gctgcgcaaa tatgttacgg 263341 aggaaccgag ctcgtatcct gctttcattg tttttatcaa tgacgggggc tgtaaaaagt 263401 caatcaaacc gataattgaa gcttcttctg ataaaccggt gttctggcag tttgtcggca 263461 tcggaaacgg aaactttgat tttctcaata aactggatac gttagaaggg cgtgtcattg 263521 ataacacgaa cttcctgcat atcgaagaga ttgaccgcat ttctgatgat gagctttatg 263581 atgctctgct tgctgaattt ccattttggc tgaaagaagc gaaggaaaaa gggattgtaa 263641 gagaacaaga gcctcctgct gaaaagccga aaaagaaggg ctttttcagc agattgtttt 263701 cgaaataact gataaagagc actgagtcat tctgcgaaat ggctcggtgt ttttgttttt 263761 ttaagatcat gtgaagaaaa ataggccgaa tgggcggctt gcaaacgaca ggatatgcag 263821 aaaacgcgtc attcagccag ctttcggcat gtttcagcag caggcttgtg agggaagacc 263881 tgtttttaat gttcagcgct tacaatcagt tcacacttct tcacagtcgt ttaacaatga 263941 tttcctataa tggagacgat caatgaggag agaggggatc ttgaatggca tacgacagtc 264001 gttttgatga atgggtacag aaactgaaag aggaaagctt tcaaaacaat acgtttgacc 264061 gccgcaaatt tattcaagga gcggggaaga ttgcaggact ttctcttgga ttaacgattg 264121 cccagtcggt tggggccttt gaagtaaatg ctgcgcctaa cttctcaagc tatccgttta 264181 cattaggggt agcgtcaggt gatccgcttt ctgacagtgt cgtgctttgg acacgtctgg 264241 caccagatcc gctgaatggc gggggaatgc cgaagcaagc agtgcctgtc aaatgggagg 264301 tcgcaaagga tgagcatttc cgcaaaatcg taagaaaagg cactgaaatg gctaaaccaa 264361 gtcttgccca ttccgttcat gtggaagcgg acgggcttga gccaaacaaa gtgtactatt 264421 accgtttcaa aaccggccat gaactaagcc ctgtcggaaa aacaaaaaca ctgcctgccc 264481 ctggcgccaa tgtgccgcaa atgacctttg catttgcttc ctgccagcaa tatgagcacg 264541 gatattatac ggcctacaag catatggcaa aggaaaagct tgatcttgtc ttccatctcg 264601 gtgattacat atatgaatac ggcccaaatg aatatgtatc aaaaacaggc aatgtccgca 264661 cgcacaacag cgcggaaatc attacgctgc aagactatcg gaaccgtcac gctcaatacc 264721 gttctgacgc caatcttaaa gctgcacatg cggcattccc ttgggttgta acttgggatg 264781 accatgaagt tgaaaacaac tatgccaata aaatacctga aaaaggacag tcggttgaag 264841 cattcgtgct ccgccgcgcg gcagcatacc aggcatacta tgaacatatg ccgctccgca 264901 tttcctcttt gccgaatggc ccagatatgc agctgtaccg gcactttacg tacggaaacc 264961 tggcgtcctt caatgtgctt gatacccgcc agtacaggga cgaccaagcc aataacgacg 265021 gcaataagcc gccttctgat gaatcgcgca atccgaatcg gactctgctt ggaaaagaac 265081 aggagcagtg gctcttcaac aatttgggca gctcgacagc ccactggaat gtgctggcgc 265141 agcagatttt ctttgccaag tggaatttcg ggacaagcgc aagcccgatc tacagcatgg 265201 attcgtggga cggctacccg gctcagcgcg aacgggttat caatttcatt aaaagcaaaa 265261 atctgaataa tgttgtcgta ctgacaggtg atgtacacgc aagctgggca tcgaatttgc 265321 atgtcgattt cgagaagaca agttcaaaaa tattcggagc cgaatttgtt ggaacctcga 265381 tcacttccgg agggaacgga gcggataagc gagcggatac ggaccaaatt ttaaaagaaa 265441 atccgcacat ccagttcttt aacgactatc gcggatatgt ccgctgtaca gtgacgcctc 265501 accagtggaa agccgattat cgggtgatgc catttgtgac cgagccgggc gcagccattt 265561 ccacgcgggc ttcattcgtt taccagaaag accaaaccgg gttgagaaag gtatcatcca 265621 caacaatcca aggcggggtg aagcaatccg atgaggtcga agaggatcgt ttcttttcgc 265681 acaacaaagc ccacgaaaaa caaatgatta agaagcgtgc aaaaatcacg aattaaggag 265741 tggaaattat gttttcaaac attggaatac cgggcttgat tctcatcttc gtcatcgccc 265801 tcattatttt tggcccttcc aagctgccgg aaatcgggcg tgccgccgga cggacactgc 265861 tggaatttaa aagcgccaca aaatcacttg tgtctggtga tgaaaaagaa gagaaatcag 265921 ctgagctgac agcggtaaag caggacaaaa acgcgggctg aatgctgatg aggcagacac 265981 cgggtctgcc tcttttttta tgaaagggag ggcttttttg aatggataaa aaagaaaccc 266041 atctgatcgg gcatttagaa gagcttcgcc gccggattat cgtcaccctt gcggcatttt 266101 ttctatttct catcacggct tttttgttcg tacaggacat ttatgactgg ctgatcaggg 266161 atttggatgg aaagctggct gtgctaggac cgagtgaaat cctctgggtg tatatgatgc 266221 tttccggcat ttgtgccatt gcggcttcta tccctgttgc cgcgtaccag ctgtggcgtt 266281 tcgttgcacc ggcgctgact aaaacggagc gcaaggtgac gctcatgtac ataccaggtt 266341 tatttgcgtt gtttttggcg ggcatctcct tcggatactt tgtcttgttt ccgatcgtgc 266401 tcagcttttt gactcattta tcctccggcc actttgaaac gatgtttacg gctgaccgct 266461 actttaggtt tatggtgaat ttgagcctgc cgttcggctt cttgtttgag atgcccttgg 266521 tggtgatgtt tttaacaagg ctgggcatct taaatcctta cagactggcc aaagcgagaa 266581 agctttccta ttttctgctg attgtcgtgt ccatattgat tacaccgcct gattttattt 266641 ctgattttct cgtgatgatc ccgcttcttg tcctgtttga agtgagtgtc accctatcgg 266701 cgtttgtcta caaaaagagg atgagggaag aaacagcggc ggccgcttag tgcagcgtac 266761 cacccggtga cttcacatcc tcatcatatt gtgcggccgt aacagcggcg attctcaatg 266821 cccggacaat cgtgtccagg ctgaggctcg gcgctgtttt gtcgattgtt tgctgcggaa 266881 tgtaaggaat atgaataaaa ccgccgcgaa tgtgtgggga tgtccggcta atgtgatcca 266941 ttaacccgta gaacaaatag ttgcatacaa aggtccccgc tgtgtaggaa accgcagctg 267001 gaatgccgtg ttccttcatc ttagcagtca ttcgtttcac gggaagcctt gtccagtaag 267061 cggcgggccc atctggagaa atctcttcat caatcggctg atgtccttcg ttatcgggga 267121 ttcgcgcatc tgcaaggttg attgccactc gttccggtgt aatctgcatc cgtcctcctg 267181 cttggccgac acaaattacg atatctggct gatgtttttg aatggcttgg cgcagagtgt 267241 ccagagcgga tctaaagacg gttggaattt gttccgctgt aataatggct tcttctgtct 267301 cgaagccatt aagccgtttc gccgcttccc atgatggatt gacggtttct ttgtcaaaag 267361 ggtcaaagcc tgtgatcagc actttttttc tcattctccc atctcctttt tcttttattc 267421 tattgtttat ttatgggttt ttcatcaaaa taatgtaaag gagtgaatca taatggagca 267481 tttgccggag cagtatcgcc agttattccc aaccttgcag acgcatacga tgcttgccag 267541 ctgttctcag agcgcattgg cagagcctgt atcaagggcg atccaggatt attatgatag 267601 cctgctgtat aaagggacga actggaaaga agcgattgaa aaaacagagt ttgcgagaaa 267661 cgagtttgca aagctgatcg gggctgaacc ggatgaagtg gcgattgtgc cgtcagtttc 267721 tgatgcactg gtttctgtag catcgtcctt aactgcattt ggaaagaagc acgttgtata 267781 tacagatatg gattttccgg cggtgcctca tgtttggcag gcacactccg attataccgt 267841 atccgtcatt ccatcaatag acggcgtgct gccgcttgaa caatatgaaa cgcatatttc 267901 ggatgaaaca gtactgacgt gtgttcctca cgttcattat cgtgacggct atgttcagga 267961 tataaaagcg attgccgaga tttctcagag aaagggctct ttattgtttg tagatgctta 268021 tcaatcagcc gggcatattc ccattgatgt gaaggaatgg ggcgtagata tgctggcagc 268081 aggcacccgg aagtatttgc tcggcatacc gggtgtggcg tttctttatg tgagaaagga 268141 gctggctgac gcactgaagc cgaaagcatc agcttggttc ggaagagaga gcggatttga 268201 tggggcttat gcaaaagtcg cgcgccgttt tcaaacgggc accccagctt ttatcagcgt 268261 atacgcagct gcagcggctt tatcgctgct gaatcatatt ggggtttctc atatcaggga 268321 tcatgtgaaa acgatctgtg ccgatgcagt tcaatatgcc gctgaaaaag gcctgcagct 268381 ggcggcggca caaggtggga ttcagccggg catggttgcg atccgggatg agcgggcatc 268441 ggaaacggcg gggttgctga agaagaaaaa agtgatttgc gcgccgcggg aaaatgttat 268501 ccgtctcgct ccccattttt ataatacgaa ggaggaaatg cggcacgcga ttgatgaaat 268561 cgcggcgaaa acgatccaca agtaaacatg aaaaagcccc tgaacactag tcaggggctt 268621 ttcatattaa tgatctactt taacgcgttt cataaagaaa gcgccaatta aaccgataat 268681 ggcaacaatc attgcaaaca caaatgcgtg ctgtacgcct gctgtcaaag cttgcgggat 268741 gactgccgga tcggcagggt ttttaactgt actcatataa tcatgctggc ctgcagccat 268801 aatgctgacc gcaaccgctg ttccgatagc gccggccatt tgctgcagcg tgttcataat 268861 ggcggtgccg tctggataaa attcacgcgg cagttggttt aaaccgtttg tctgtgcagg 268921 catcatgatc atagaaatcc cgatcatcaa gcaggtgtgc aggatgataa tcagcacagc 268981 tgttgaagtg gtcgtgacat ttgagaagaa ccatagtaca acggtgacaa tcacaaatcc 269041 cggaatgaca agccatttcg gcccgtattt atcgaacaag cggcctgtaa caggggacat 269101 aaatccattt aaaataccgc ccggcaagag aacaagacca gatgcaaatg cagtgaggac 269161 taagccgcct tgcagataca tcggcagaag cagcatagat gacagaatga ccatcataca 269221 aatgaacacc atgatcacac ccaaaataaa catcgggtat ttgaacgcac ggaggttcat 269281 cataggctgc ttcattgtca gctggcggat tgaaaataag ataaggccga caacgccgac 269341 aatcagcgac acgataacag tcgggctgga ccatcccccg gagccttcac ccgcgttgct 269401 gaatccgaat acaatgccgc cgaagccaat cgtcgacagg atgatagaca atacatcgat 269461 tttcggcttt gtcgtttcag atacattttg catatatgcg ataccgaaaa caagcgccag 269521 cacaaggaat ggaagagaga tccagaaaat ccagtgccag ttgagatgct ccagaaccaa 269581 tcctgagaaa gttgggccga tggcgggcgc gaacataatg acaagcccga tcgttcccat 269641 tgcggcaccc cgtttatgag gcgggaaaat caccaagatt gtgttaaaca tcagcggcag 269701 taaaagaccg gttccaagtg cctgaacgat ccttgccgct aataaaaacg agaagctcgg 269761 cgcaagcgcc gcaatgaatg tacctaaaat tgaaaagata agtgacacgg taaaaagctg 269821 tcttgttgtg aaccactgca acagcagtcc tgaaacagga acaaggatac cgagtacaag 269881 caggtagccc gtcgttaacc attggacggt tgccgctgta atgttcaatt ccttcataag 269941 gtcggttaac gcaatattca gcgctgtttc actgaacatg ccgataaaac cggccaacag 270001 caaggaaatc ataatcggca tcactttgta ttgctgagat gctttagctg ttgtttccaa 270061 aatcatttcc cctctctatc aactgcatgt agtatgtcgt tttttttatc tcttcagcag 270121 gtcaggaatg cagctggaga tatgaaggag cggcgtactg ttttttgccg tcaaagataa 270181 aaggatgccg ccttcaatca tcgcgttaac cacagtgctg gcttcttttg cacggctctc 270241 gctgcagcca gtctgccgca gtttttcctc atacacagag gcccattctt tgtaggcttc 270301 atgacaggct tcgcgcaacg gttcgctttt caatgacgtc tcagccgcta gcaagcccac 270361 aggcaagcct tcaatgtctt ccgtacatga aaactggcag gagagctcct tcaaaaaggc 270421 ttgaatgcct tccgctggat cggtgcaggc ttccatgcag tccgcgattt tctgacggat 270481 atactccttc atctcattca cggcttcgat cgcaagctgt tctttacccc cgggaaagtg 270541 gtagtaaaga gagcctttag gcgcgccgct ttcctttata atctggttca gccccgtgcc 270601 gtaataccct tgcagctgaa aaagccgggt agctgccgaa aggattttct cacgggaatc 270661 tccataactc ataacattcc caccttactg aattgcaatc aaaaatatag tgactggtct 270721 attatcttga ttcaatcatc aattgtcaag aaaaattcat tgtatgaaaa gacaaaaaaa 270781 gaaggatatg acaacaaaaa atactgagag aaaagctgac tgatcttttg actgaataga 270841 taaaatgtac aatgattaat catcatatgg atgtaaggag agaaatagat gaaaaaacaa 270901 cgaatgctcg tactttttac cgcactattg tttgttttta ccggatgttc acattctcct 270961 gaaacaaaag aatccccgaa agaaaaagct cagacacaaa aagtctcttc ggcttctgcc 271021 tctgaaaaaa aggatctgcc aaacattaga attttagcga caggaggcac gatagctggt 271081 gccgatcaat cgaaaacctc aacaactgaa tataaagcag gtgttgtcgg cgttgaatca 271141 ctgatcgagg cagttccaga aatgaaggac attgcaaacg tcagcggcga gcagattgtt 271201 aacgtcggca gcacaaatat tgataataaa atattgctga agctggcgaa acgcatcaac 271261 cacttgctcg cttcagatga tgtagacgga atcgtcgtga ctcatggaac agatacattg 271321 gaggaaaccg cttatttttt gaatcttacc gtgaaaagtg ataaaccggt tgttattgtc 271381 ggttcgatga gaccttccac agccatcagc gctgatgggc cttctaacct gtacaatgca 271441 gtgaaagtgg caggtgcccc tgaggcaaaa gggaaaggga cgcttgttgt tcttaacgac 271501 cggattgcct cagcccgata tgtcaccaaa acaaacacaa ctacaacaga tacatttaaa 271561 tcagaagaaa tgggcttcgt cggaacaatt gcagatgata tctattttaa taatgagatt 271621 acccgtaagc atacgaagga cacggatttc tcggtttcta atcttgatga gctgccgcag 271681 gttgacatta tctatggata ccaaaatgac ggaagctacc tgtttgacgc tgctgtaaaa 271741 gccggagcaa aggggattgt atttgccggt tctgggaacg ggtctttatc tgatgcagcc 271801 gaaaaagggg cggacagcgc agtcaaaaaa ggcgttacag tggtgcgctc tacccgcacg 271861 ggaaatggtg tcgtcacacc aaaccaagac tatgcggaaa aggacttgct ggcatcgaac 271921 tctttaaacc cccaaaaagc acggatgttg ctgatgcttg cgcttaccaa aacaaatgat 271981 cctcaaaaaa tccaagctta tttcaatgag tattgaagaa aagaaggcga ataagccttc 272041 ttttttttgg ctttttagga ccaataatga cctctgaatc ttaaaatttc tttaaaaata 272101 agccaaaatt accctttact taattaattt ggtaacgtaa tataattgga gaatttgtta 272161 caaaaaaagg aggatattat gaaatttgta aaaagaagga tcattgcact tgtaacaatt 272221 ttgatgctgt ctgttacatc gctgtttgcg ttgcagccgt cagcaaaagc cgctgaacac 272281 aatccagtcg ttatggttca cggtattgga ggggcatcat tcaattttgc gggaattaag 272341 agctatctcg tatctcaggg ctggtcgcgg gacaagctgt atgcagttga tttttgggac 272401 aagacaggca caaattataa caatggaccg gtattatcac gatttgtgca aaaggtttta 272461 gatgaaacgg gtgcgaaaaa agtggatatt gtcgctcaca gcatgggggg cgcgaacaca 272521 ctttactaca taaaaaatct ggacggcgga aataaagttg caaacgtcgt gacgcttggc 272581 ggcgcgaacc gtttgacgac aggcaaggcg cttccgggaa cagatccaaa tcaaaagatt 272641 ttatacacat ccatttacag cagtgccgat atgattgtca tgaattactt atcaagatta 272701 gatggtgcta gaaacgttca aatccatggc gttggacaca tcggccttct gtacagcagc 272761 caagtcaaca gcctgattaa agaagggctg aacggcgggg gccagaatac gaattaatga 272821 aaaacaaaac cttgaagaat gctattcttc aaggttattc tgctttcagc acaatggttt 272881 tcgcagccat atcatgaacg gtttgttttt tcttcgtaaa tgcggcagtc aaatagatca 272941 ggcgggagaa cacatgcacc cacgctatca ggtaacggac aatggcttgc gggaaggata 273001 tttttttata tgtttcgtcc ctcacgattt gcagcccgat gatttttttg cctagtgtgc 273061 ccttccaatt tgtcagcggc atcagcaaag ggtacacaat cagcatcaat atggcgacaa 273121 taatgacacc ggcggaccca tcgccaaacg taaatccggc tgccaaaatc actgctgcgg 273181 caatgattac atcaagtaaa agagcgcagg cgcgcagcat gaaaccagct agttccaata 273241 gaaacactcc ttaaaatgtt aaataaacac ctaatgattg taaaaaagaa gggcctaaag 273301 tgggaatagg tgataagcct taaatcacaa aagttggtga aaatgtcata ggtaaattgg 273361 cataatcagc cagcttatca cattaccaaa ttctttttta gcccgaaacc aagccctcag 273421 aagttatttt tgttaaaata gaaaagttac aacagaattc ggagggttta ttgtgggaaa 273481 agtgaaacga aatgcccctt gcccatgcgg cagcggcaag aaatataaaa aatgctgcgg 273541 aagtaaagtt gtcgacttcc cggcggaact agcggcaaaa gaagcgaaac aaattcagga 273601 agacttagtg gagtatgcct tcacagtaca tagagaaagc atttcaggct ttatcaacca 273661 gcatgatttt ctttctgcta tggacagaca gacgaaagac atcagcgtat ttaacttagg 273721 aatctgggga atcttcttcc acccgcttgc tggtgagaag acaatcttcg aagagtacct 273781 tcagaaaaaa ggcgattcga tcactcgtcc gaaaacgcgt gagatcgtag aatcatggca 273841 gagcatgacg cctgctttat tgctgctgaa ggacctgaag gaaggcatca ttcactttga 273901 agatgtcatt acggcaaaac aattcgaagt ggaaatggac gccagcaatc aagaccttcc 273961 tccagtggga agcctgattc ttggataccc aatccacgaa gcggaaaaag cagaattctt 274021 catgcagttc acgatcttcc cggtgaagag aacagaagcg ctgatcagca aggtgaagaa 274081 atatgcggat gccgctgtga aggacggcaa aacgccggag gacttcatga agcaggaatt 274141 caacaacgtt ctgttcgcgt tgttagctga gaaagatgaa gagccacaag cagagaaagc 274201 ggaagtaagc actgttgagt gggcaaacga cttggagaaa gaaaccgctg cggctattga 274261 agaaggcatg agcggggaag agtatccgac tgaattgatc ccagctgtta ttgacatctg 274321 gaaaacattc tgcgagaaaa aatcacctgt catcagaaag ccggaagctt ttgcggcggc 274381 agttgaatat tatgtaaacg caatttctct taacggcgcg tccgtttccc aggctaaact 274441 ggcgaaaaaa tacggcgtta gcgcatcaac gatttccagc cgttacaaag aaattgaaag 274501 cacgctgcaa gatgaagcag atcgttttgc acaagcgtta tcctcataat ggaaaaaacc 274561 ttgaaaagcc aggcttttca aggttttttt atttctgaaa cggaattttg atttctaacc 274621 ggaagatggg gtggcggtag gtaaaatcca gcctgccaaa agcgcccttc accagttttt 274681 gaatgatata tgtgcccatg ccttcatgag cgccgttttt cgttgagcgg ccaaacgatt 274741 gataaattgt atcgagcact tttgggtcca tcccgggagt gctgttttca caagtcagta 274801 cataaagccc gctgcgcagt gaagtctcca gtttaatctc tgctttttct cgggcctccg 274861 ccgcgctgtc gagcgcattt tctaatatgt tgccgaccaa gctgacctga tcagcaggcg 274921 aaaacggaag ggaagaaagc ggtgtatgca tatgcagcga aacactcaca ttcgaggcgc 274981 gggctttttc taaaaaatca taaagcaccc ctgcaacgta cgcgttctct cctttcaaaa 275041 aacggtcata ttggctgtat tgatccgccc agttttgaat atatgcttgt gtatctgcct 275101 tgggctgagc tgatttgatt gcagtgatat gtttcattgt gtcatgattc cggcttctga 275161 catcaatcag catttgattg gcgtgctgtt cagcttgagt cagcttatca atttgatcag 275221 aaagccttgc ctgcaaagca gactgtccga tacggagccc ttcacaccct gcaaatatcg 275281 cgattacaca taataccggc atgatgtctg tgccaatcaa caccactccc accgacatca 275341 cttgaatcac cgcaatccac gcacaaagcc ctgaggaaca gtgtttccac acccgcttcg 275401 tattccaaat gtacaatcct gcagcagctg cgcctaaagc agcggcgagc caagaggcgg 275461 ctgtgctgtg tgaaaaagca gcagctccct gataacatat gaaactaaat aaaatcagat 275521 aaagacattg aaaaagggta atcacgtact aaactcctca aaaatagtag ttttgaaaat 275581 aatcaagctg ctgcttagtg atcatcgctt ttttagacgt tccctcaaag gaaactgtga 275641 atgaatgctt ggtataagcg gaaaaatgct ttatgtaatg aatgttgata ataaaggaac 275701 gatgcgaacg aagaaaatct ttttcgggca ggtcgccttt aatatcattt aatgtttgat 275761 acgtttgcac ctcttcggcg gttgtcacaa tcgtcgtcga acgtcccgtc cgttctgcga 275821 aaataatatc cttcttttgc aggacgtgca tttcagactt ttgctttatc aatatacgcc 275881 cattcaaact cgtttccgtt ttctttttca agtaccggtc gaaggaagcg gccagacggt 275941 cggcatagta cggcttcata atataatcat ggacgttcag gtcaaaggcg tgaaccgcat 276001 aaccgccgtg gccggtaaca aaaatcacat ccacatcaag tgaatgggat ttgatcaaat 276061 cagcaagctc gtagccagac atatggggca tctcgatatc ggcaagcagc agatcaatgt 276121 ctccgttctt tacccgcctg taggcttcct tcgctgaatc ggtggaaaag acaatttcga 276181 cgtcctgcat tctggacacg atcgcttcta acttctctaa atctactcga taatcatcta 276241 caagtccgac ttttaccatt atcattcccc tagttacata gaatcatctt tattctatcc 276301 catttcacga cataaaaaga actcttcgcg acaactttat ccaactaatc cagcttttcg 276361 tatatagtca ttactagaaa taaagataag ggagattgtg acatgattac actgaccgat 276421 tgcagccgca ggtttcagga taagaaaaaa gtagtcaaag cggtgcgaga tgtaagctta 276481 acaattgaaa aaggagaagt cgtcggcatt ctcggagaaa acggtgccgg caaaacgacg 276541 atgctgagaa tgattgcttc cttgcttgaa ccatcacagg gtgtaatcac agtagacggc 276601 tttgacacgg tcaagcagcc ggctgaggtc aaacaaagaa tcggtgtctt attcggagga 276661 gaaaccgggc tttacgacag gatgaccgct aaagaaaatc tccaatactt cggcaggctg 276721 tatgggctga accgccacga gatcaaagca agaatagaag atttatcgaa acggttcggc 276781 atgcgcgatt atatgaaccg gagagtgggc gggttttcga aaggcatgag gcagaaagtc 276841 gccattgcca gagcgctgat tcacgatccg gacatcattt tatttgatga gccgacaact 276901 gggcttgata ttacgtcaag caacatcttc cgcgaattta tacagcagct gaaaagagaa 276961 caaaaaacga ttcttttctc cagccacatt atggaggaag tgcaggcgct ctgtgacagt 277021 gtcatcatga ttcacagcgg agaggtgatt taccgagggg cgcttgaatc actatacgag 277081 agcgagcgca gtgaggattt gaattacatc tttatgtcta agcttgtcag ggggatttct 277141 taaatgctga gccatattta taaaaaagaa atgatcgacg ctttacgcga cagaaaaacg 277201 atattactca caatcttagt gccgatgatt atgatgcttg gacttgtctt tttttatgaa 277261 agcatgctgt ccgacaaagg ggagcagtac acgctggctg tcggccattc gcttccgccc 277321 gcactggaaa gcaagcttaa tgagattgac gaaatcagcg taaaaacatt tgcaaagcct 277381 gaagaggcag ttgatgaagg aaaagcagat gcctatctga acgtcccgaa agagttcgac 277441 tcatatgtca acagcatgac accttttaag gttgatgttt acggcaattc aatcgatcaa 277501 gggtcgtcaa atgccatgca gcttgtgcag tctgccttag atcagtacaa aaatgaaatt 277561 gtgcagcaac gtttaacaaa taagcatatt gatcaatcgg tgatccagcc gtttacaatt 277621 cagcaaaagg aagcggatga ggagaaaggg acttccgcta ttatgctttc cgccattctg 277681 cccatgctga ttctgacttc cattgtttcc ggcgcaatgc cgatcgctct tgatatcatg 277741 gccggtgaaa aggaccgaaa gtcaatcgag gcgctgctat taacgccagt cagcagaaac 277801 aaagtgctgg tcggcaagtg gcttgcggtt tccacttttg gcgtggcttc aggtgtattt 277861 gctttggtgt ttttgatttt gtccaccgtg ttatttaccg aaaatttaaa aacggccttc 277921 cagctgggag atcatatgtg gagtgtaatc ggcgcttcag ccttaatcat tgtgctctct 277981 gcattgctga tatctgcgat ggagcttttc atcagcatca tgtccagctc ggtaaaagaa 278041 gcgcaaagtt atatgtctct cgtcgtcttt ctgcctgtgt tcccgatgtt tttcatcttc 278101 agcaaggcac cgaaccaatt tgacttatca tactttctca tcccgtttct gaacctgcat 278161 gcgttattta aacagctttt attcgggatg gttgacccgg ctaccatttt gtctacgtca 278221 ggaaccatcg ccgtgctcat cgccatcttc tttttactag ccagagcctg cttcctgaaa 278281 gacaaatggg ttcttccaaa ataaacttgc gaaaggagaa atacactttc tcctttttgt 278341 atatcctgaa aaaagaagga aaatagaaaa aggatatcta atacaaaaag tgaccctgca 278401 ctatttttca tcaaaattgg tttcaaagga gaaggaacaa tggatcaaac acgtacactc 278461 ggcaaaacga agctgaaggt gaagcggatc ggattcggcg cgaatgcggt cggcgggcat 278521 aatctatttc caaatctaaa tgatgaaaca gggaaggatt tagtgcgcac ggcattggat 278581 ggcggcgtca attttatcga taccgccttt atatatggat tggggcgatc tgaagaatta 278641 atcggcgaag tcgtacagga acgcggcgtg cggaatgagc tcatcatcgc caccaaagga 278701 gctcataaag aagtggacgg cagcattgaa ttagacaata gccgggagtt tcttcgcagc 278761 gaggtggaga agagcctgaa gcggctgaaa acagattaca ttgatttgta ttatgttcac 278821 tttccggatg gaaaaacacc tctcgctgaa gtggcgggca ctttgaaaga gctgaaggat 278881 gaggggaaaa tcaaagcgat cggcgcttcg aacctcgatt atcagcaatt gcaggatttt 278941 aatgctgacg gctatttgga ggtcttccag gccgaatatt ctctcataca gcgtgatgcc 279001 gagaaagagc ttcttccata ctgtgaaaaa caaggcatct cctttattcc ttactttccg 279061 cttgcgtccg gactgctgac aggaaaattc acgcaagaca cagtctttga tgatttcaga 279121 aaggataaac ctcaatttca gggtgaaacg tttatccaca atctcaaaaa agtagataag 279181 ctgaaagcag tagcggagga aaaacaagcg gatacggcac atgtcgcctt ggcgtggctg 279241 ttaacgagac cggcgattga tgccattatt ccaggagcta aacgaccgga gcaattacag 279301 gataacctga aaaccttgaa cattgaactg accgaagatg aagtgaattt catcagcgac 279361 attttcaaat aaaaaaggaa atagccgtca tggctatttc cttttggtgt tttattcttt 279421 gatgaatgct tcgactaatt ctgctgctct gtaatcatcc atatcaagct gccattggtc 279481 gatgtcattt ttcttcattt tcacttcaac tgttttttca gatgaagcag gtccaagctt 279541 tttgaattcc tcaggataga cttgaagcgc gtatttcact gcctcttcat agctggcact 279601 agagttttta ctgtagtagt ctttcacttt gtcttcgatg cggtctgaaa gagaagatgc 279661 atctacaggt ttaactgtgg cttcaacaat tgcttcgtct ttagagattg aagtcgtttt 279721 tgcttgaatg gaagagtttt tgcttaatcc ctctttaatg ccgttcacga tattatcaag 279781 cgctttgctg tccgcatatg tgctggaaag gccggaagct gagagataac cgtctttggc 279841 tgattcatta aaatcattta caatttcatt tttgttagcg ccggtgattt tttcgaaatc 279901 ggcgttatct ttgccgaaaa gaaggacatc aacataagct gataacgctt ttgcagaatc 279961 ttggagctta tctgccgtcg ccaggatttt tttgtctttt ccgtcaattt taaaagtaac 280021 tgattttggc tttttatcac cgtaagattc cggcgtatag ttaagctcgt attgcttgcc 280081 tttatctaca acgaagaaaa gatttccttc aacggatttg tcagcgttaa tcgtgctgcc 280141 ctgaagcttt tcgctatagt cttcagggtc tgtgtcagac attttggtat caccttgata 280201 caatgtgaaa tccatactgt ctacattcag cgggtctttt cctgtgtttt tcaccgcgac 280261 attgactttt aacacaagct ggtcatctga agtggactta tcatatttag acggaagtgt 280321 gtaagagaca tccttgattt tgacttgagc tatatctgag cttttttctg tttctgattc 280381 tttcttctcc gcgcttgttt tgctgccgga acaagcagct gtaaacatca tcagcagaag 280441 aattaggaaa acagcgtacg tttttttctg aaacattcat ttttcctcct caaatggttt 280501 aggaaagggg agtcttttgt ctttgagaaa tggatctttt tgaatggatt agcatcatat 280561 aaccaaaaaa atcagttctt ttctcacggt tttcaccgga ttttctggaa actccgccct 280621 cctttgtcat gaatggacct ataaaaagtt acaacggaat taattttaag attattagct 280681 tttatattga ataggttcat catcctattt ttggtgaaaa atgttctggt aaaactggta 280741 aactcagaaa actgtgtatt ttagactatt actttttgat tagttggagg gaacttaaga 280801 aggatgaaag gggccgcctt tgtgaagaaa gagggactga aacaaaaagc actggaaatc 280861 ggccgggtgc cgacacactt aaaactggaa attgaagatt atggcggtga tgataaaaga 280921 gctcattttt gttgggcaga tcctcaggat gagaataccg gcattatcgt ggagcttgga 280981 ccggacggag agctggaatc cctttcccgt gatattgagc ctgaaagcgg agaaaggctg 281041 tctgaggaga aactagagga tatcatgcgc caatttgtcg agactcatca tccgggggca 281101 ctctctgcct ttgttcgtga agaaaatgac cgtgcatacg gcgataaagt gagattttca 281161 tatgttcaaa tggaggctgg gcttcctctc cccatgagcg gatttatggc tgatgtttcc 281221 ttatcaggtg agattgttta cttccgttat tacggcgaag cgggcagcat catcaagcca 281281 aagcgggtcg cggatgttga agaggcactt gcctttatca agaaggacgt ggagttcgac 281341 cttttgtttg aggttctcca tcgttctgtt tacaaaaacg gagatgatca gccgcatttg 281401 gtgtacgagc ctgaaggtag ggcgattacc gtacctgcgg atttggttca agaagaacaa 281461 gcagttgatg atgacgatga ttacagggag ccggagagct ttcctctccc tttattcgag 281521 ggcatccgcg aaaaggccga tcctgacagc atgattggta ttgaaaatgg gtttgtcaaa 281581 gagcgggaag cggatttggg agatgggaga attggaatcg tttggcggaa tccggatgac 281641 cctgtgtatc agccggcgga taaaagcatg gacagctggt ttaagggacg gactcatcaa 281701 gtgctgaaaa ccatctataa caaagaaacc ggaaaactcg aaggcgtcat gtcatttatg 281761 gagaaaaaag ggccgctgac agtaaccttg gcagagtgtg aaaaaatcgc gcttcgcttt 281821 ctatttgctt tatttccgaa tgccgatcaa tattttagga tcagatacga cgaaaaagat 281881 gaagaagaaa acgcagtcgc tggttttacg tttgaagcgc attgtcacgg agttccgctc 281941 cgatttgggc agatcagaat ttgtgtcagc cgccagacag ggtatatcac cgtttatatg 282001 ggaccggata ttgacccaaa taagctggca accattgatc ctgtgccggc tatttcagtt 282061 gaacaagcca agtctatctt ttggcagcat tttaaagttg agcttggctg ggaaagagag 282121 tacggggatg atgaagaaca cagctaccgg ctcgtctata agccggtgta tccgcatttt 282181 atcgatgcac atacagggga gcctgtcttc agcatatggt gaaacagcca aaagtcacgc 282241 aattgcctca gatatagaag agagtatgtg atgaaagtaa cagaaagaat ctcaaaaaac 282301 aatgacaata atagaaaagg acctttcttc actttaaatg aagaaaggtc tttttatata 282361 ataaacagga ttctctttgt cgtagactct ttgaaaggga tgacttcatt ggttaataaa 282421 cagctgaaaa agaaggcgca ggagatcgga aatgtaccga cgcattatga gcttgagata 282481 gaagattacg accaaaagca aaagaagtac gggcaggcat attttatctg gaaggaccct 282541 aaagatccgg aaaagcacat tacagttgaa cttagaaatg acggcgcctt gctcaccttt 282601 tcaacaactg tccactccga gacagacaaa aaacttccag atgccgagct gaagctgacg 282661 gctcttcagt ttgccgctgc caatcatccc ggcacattta tgaattttca ttttcaaggc 282721 aaggaagaaa gggggcagca catccggttt gtctatacca aaatggagct ggggcttccg 282781 attcccaatt caggcttttt aattgatatg acacgaagcg gtcagattgt ccactttcta 282841 tattacgggg aagggcataa agccgaagtt ccgacggaat ttgtagcaaa agagaaggtt 282901 gtatcccatt acttaaacac aatgtctttt gagctgatgt acgatgtcat tgatggcgaa 282961 caggaaccaa ggcttgtata tgaaccgatt ctaccgggat acagctatcc cgcagatgta 283021 gacgaaattg tgcccgacca gcatatcgca gatgaaagaa tagaaaacac ggcgccactg 283081 ccgccgcttc agaacaagga agaagttgat atatttgcct tgctgggttt tacctctgat 283141 atgcagaaag tcagtgaaag agactttgga gaacaaattg gaagcacgtg gcgcaggggc 283201 gctgcgccgg agcgtaagga tttaagcata ggaagctatt ttgaaacgag aaataaaaat 283261 acaatcaaaa tgaagacgga taaaagaacc ggaaaattaa aagcagcgct ttcttttatg 283321 gactggcgga acaacctcca atgctccacg gaagaatgcc aagagatagc gcttcaattt 283381 ttgtatgccc tctatccgag agcggctgag tttttcaggg tgaatcccgt ccgaattgat 283441 gaaagaggga gagtccgcaa ccatttttct gtctggtata aaggagtgcc gctgcggttc 283501 ggcgctgccc gcatcattgt caatccggaa actgggttga ttgacgcttt tatggcgcct 283561 gatattgaac ctgaacaatt ggaagcgata aatcacaggc cggatgtttc cgctgaagaa 283621 gcgaaagaag catttttagc cgcttttgat gtgaaactgg aatggcagcc tgattttaca 283681 gcaggcagtg accagcactg caaacttgtc tataagccgg tttacccttc ctatattgat 283741 gcgcacataa ggaaaaagaa aaggctgtga ggggtgtcta gttaggaatc atctccaagt 283801 gggggtagtc cttgaatcgt ttccaatccc cgccccattc gaaaccgagt gtcttagcga 283861 tctcgacaac ctccagccaa tctgattttc cgttttgatt gccgtcatat tccatatccc 283921 atatgatgct gccatccttt ttttgaaggg cgaaatcaat cgctaaacca tagttatgat 283981 acgattcccc tcctcttgca taggtgacaa tattcccttt ttttgtacgt ccctgtttat 284041 ataattcatc ttgttcctta aaggacctga atccttcagt aatgacgacg tcaatgcctt 284101 tattcgctgc agcggctttg agtgcatcgg cattctgctt cacaatcgga tgaagatccg 284161 aggggacagg catgtcctgc aaggcgtttt gagaatgcca ttcatgccga atataactaa 284221 aacaaagatc tagaagaaat agaatacata agataacaaa tgtttttgcg ggtaagttca 284281 tatcggtctc actttctcaa gatgtgctga atgttaacgc ttttaagtga ttgactctct 284341 ctaaaagcga acagctatga taaaatataa cataaatagt agcaggagga aggaggcaga 284401 ccgatgagag caaagattcc atcagaagaa gtagcagtaa agctgaatga atggtacaag 284461 ctcattcgcg catttgaagc agatcaagca gaagcgttaa agcaggagat tgaatatgat 284521 ttagaagata tggaagagaa tcaggacttg cttttatatt tttctttgat ggaattccgg 284581 catcgaatca tgcttgataa gctgatgccg gtgaaagaca gcgataccaa gcctccgttc 284641 tctgatatgc tgaacgaaat tgaaagcaat cagcaaaaac tcacgggctt actggaatac 284701 tacttttatt atttcagagg aatgtacgaa ttcaagcaga aaaatttcat attagcgatt 284761 gaccattata aacatgccga ggaaaagctc gagtatgtcg aggatgagat cgaaaaagct 284821 gagtttcttt ttaaagtcgc agaagtgtat tatcacatca aacaaacgta tttttccatg 284881 aattatgcga gccaggcgct tgatatctat acgaaatatg aactgtacgg tcgccgccgg 284941 gttcagtgtg aatttatcat cgccggaaat ttgaccgatg tgtatcatca tgaaaaagca 285001 ctgacccact tgtgcagcgc tttagaacat gccaggcagc ttgaagaagc gtacatgatc 285061 gctgctgcct attataatgt cggacactgt aagtacagtc tgggtgatta caaagaagcg 285121 gagggctatt tcaaaacagc cgccgccatt tttgaggagc acaactttca gcaagctgtt 285181 caagctgtat tttcactgac ccatatctac tgtaaagagg gaaaatacga caaggcagta 285241 gaggcttatg accgcgggat aaagagcgcg gctgaatggg aggatgacat gtacttgacg 285301 aaattccgcc tcattcatga gctgtatctt ggaagcggcg acctgaacgt gcttacagaa 285361 tgctttgacc tgctggaatc caggcagctt cttgctgacg ccgaagatct gctgcatgat 285421 acagcggaac gtttcaatca gttggaacat tacgagtccg ccgctttctt ttaccgcagg 285481 ctgatgaata ttaaaaagaa gcttgccgag cagcgttttc aataggaaat ggcagagaac 285541 tacaggttct ctgctttttt tgtgctgttt tcaactcgga aaaacagggt attttccact 285601 gcatagtgag aaacagagga ggatatcaag tatgtacaaa gatttaaccg gaaaaacagc 285661 gattgtgaca gggtcttcaa aaggaatcgg gaaagccatt gcggaacggt tcggaaagga 285721 gaaaatgaat gttgttgtaa attaccacag cgacccgtct ggagcagatg aaactctgga 285781 aatcattaag cagaacggag ggaaagccgt ctcagttgag gcggacgtgt caaaagaaga 285841 ggggattcag gcgctcttgg acacagcttt agagcatttc ggcacgctcg atgtgatggt 285901 aaacaactcc ggttttaacg gcgttgaggc gatgccgcat gagatgagtc ttgaagattg 285961 gcagagagtg attgatgtca atgttaccgg aacctttctg ggagcgaaag cagcacttaa 286021 ccacatgatg aaaaacaata tcaagggcaa tgtgctgaat atctcaagtg ttcatcagca 286081 gattccgcgc cctgtaaacg ttcagtattc cacatccaaa ggcggcatca agatgatgac 286141 ggaaacgctg gcgctcaatt atgcggataa gggaatccgc gtcaatgcga tagcgcccgg 286201 caccattgcc acagaatcaa atgttgatac gaaaaaggaa gagagcaggc aaaaacaatt 286261 gaaaaaaatc ccgatgaaag ccttcggaaa gcctgaagaa gtggcggcag cagcagcttg 286321 gctcgtatct gaggaagcaa gctatgtgac cggcgcaaca cttttcgtcg acggcggaat 286381 gacactttat ccatctcagc ttgaatagaa gacaaaacag ggggattgcg ggatgaaaac 286441 agactggtgg aaggatgcag tggtgtacca aatttacccg agaagctttc aggacagcaa 286501 tggagacgga attggggact tgcgggggat tatttcccgt cttgactaca taaaggagct 286561 cggggcagat gtgatttgga tttgcccgat ctatccttct ccgaatgttg attacggcta 286621 tgatgtgaca aaccataagg cgattatgga ttcttacgga acaatggacg attttcacga 286681 gctgctggac caggtgcatc agcggggatt aaagctggtg atggactttg tgttaaatca 286741 cacctcggtc gagcatccgt ggtttaaaga agcggagctg gacaaaaaca gcaaataccg 286801 tagctattat tattggcgtc ccggcacaaa gaacggcccg ccgacggact ggctctcaaa 286861 ctatggatgc ccggtctggc aatacgaaga gcacaccgga gaatactatc tccatatgaa 286921 tgccgtcaaa caagctgatt taaactggga aaatcccgaa gttcgccagg cggtgtatga 286981 catgatgaaa ttttggctcg ataaaggggt cgacggtttg cgaattgatc agctccatct 287041 catttctaag aaagaatatc ttccttcgta tgaggactat atcaatcagc aggcagagcc 287101 gaagcccttt cagccaaatg gcgaacgaat ccatgactat ttaaaagaaa tcacagatga 287161 agtgttttct cattatgatg tcatgtctgt cggagaggtc ggcagtgtca caccggaaga 287221 aggcctgaaa tatacgggaa cagataagca tgagctgaat atgatttttc actttcagca 287281 tatggagctt gatcagcagc ccggaaaaga acattgggat ttgaagcccc ttgagctttc 287341 tgatttaaaa tcggttttga caaaatggca aaagaagctt gaacatcaag gctggaatac 287401 attgttttgg tgcaaccacg accagccccg gattgtgtcc agattcggag acgatgggga 287461 ataccgcaaa gcatcagcga aaatgctggc agccgtaatt tattttatga agggcacgcc 287521 gtatatttat cagggagaag aaatcgggat gacaaacgcg ccgttcaccc ggattgaaga 287581 ctacaaagat atccaaacga tcaatatgta tcataaacgg gtgtttgaaa aaggctatga 287641 tccaaatgat gtgatgagat cgatcttagc caaaagccgg gatcacgccc ggaccccgat 287701 gcagtggaac agcggcaaaa atgccggatt tactgacggc acgccttggc tgaaggtcaa 287761 tccgaacttc accgcaatca atgtggagga agcgcaggga gatcctgatt ctgtcttaaa 287821 ctattacaaa aagctgatca gcctgagaaa gcagtacgct gacctcatga aagggagctt 287881 tgatcttttg cttccggacg atccgcagtt gtttgtatac atgagagaaa acagtaaaca 287941 acagcttttg tcggtcaata atttttcaaa agagcaggct gtttttcagt ggcctaagaa 288001 ctgcggcaaa gctcaggcct cactgcttct cagcaattat aacaacgatg atcttgatga 288061 cgaaatggtg ttccggcctt atgagagcag ggtctatctt ctggacaaaa caaactaatg 288121 attgaagtag cccggcattt ttagccgggt ttttttagta catatattcg ctctgcaggc 288181 gggaagaata aatgaaaatg aaatttattc ttgcaaaacg taatgacttc ggtttattat 288241 gatataggat tacaaaatcg ttatcatttt gatttaaagt tactgaaaaa gaggggatat 288301 acgatatgtt taaaaaatgg agcggtttgt ttgtgattgc agcgtgcttt ttattagttg 288361 cagcatgcgg caactcatca acaaaagggt cggcggattc aaagggtgat aaactgcacg 288421 ttgtcacaac gttctacccg atgtatgaat tcacaaaaca aattgtaaaa gacaaaggcg 288481 atgtggatct gttaatccca tcttccgttg aaccgcatga ttgggaaccg acgccgaaag 288541 acattgccaa cattcaggat gctgatttgt tcgtttataa tagtgaatac atggagacat 288601 gggttccgtc agctgaaaaa agcatgggcc aaggccatgc cgttttcgtt aatgcaagca 288661 aaggcattga tttaatggaa ggctctgaag aagaacacga agagcatgat catggggagc 288721 atgagcacag tcatgcaatg gaccctcacg tatggcttag ccctgttctg gcacagaagg 288781 aagttaaaaa tattacggct caaatcgtga agcaggaccc ggataacaaa gaatactatg 288841 agaaaaatag taaagaatat attgcaaaac tgcaggatct tgataaacta tatcgtacaa 288901 ccgcaaaaaa agcggagaaa aaagaattta tcacgcagca tacagctttt ggctatctgg 288961 caaaagaata cggcttgaag caggttccga ttgcagggct ttcacctgac caagaaccga 289021 gcgcagccag cttggcaaag ctgaaaacat atgccaaaga acataatgta aaagttattt 289081 actttgaaga aattgcatcc tcaaaggtcg cagatacgct cgccagtgaa atcggcgcga 289141 agacagaagt gctgaataca ctggaaggct tgagcaaaga agaacaggat aaaggtttag 289201 ggtatatcga cattatgaaa caaaacctcg atgccctgaa agattcacta ttggttaaat 289261 cataagatag tgtgcgccgg aggggtgcac actatttctt tgtgagaaag gaagattaac 289321 atgaatctcg tctcattgaa agatatcgtt ttcggctatt cccatacgcc tgttttagat 289381 aaagtatcac ttgatattga aagcggtgag ttcgtcggca tcactggacc aaacggcgcc 289441 tctaaatcga cgctcataaa ggtaatgctc ggcatgctga aaccgtggga aggcacagtg 289501 acgatcagta aaaggaatac agaagggaaa cgcctgacca tagggtacgt cccgcagcaa 289561 atttcttcat ttaatgccgg atttccgagc acggtgctgg agcttgttca gtcaggccgc 289621 tatacaaaag ggaaatggtt taaacgttta aatgaagaag atcatcttga agtagaaaaa 289681 gcattgaaaa tggtggaaat gtgggacctc cgccatcgta aaatcggtga tttatcaggc 289741 ggacagaaac agaaaatctg tatcgccaga atgctcgcca gcaacccgga tctgctgatg 289801 ctggacgaac cgacgacagc tgttgattac gacagcagaa aaggatttta cgaatttatg 289861 catcatctcg tgaaaaatca caaccgcaca gttgtgatgg ttactcacga acaaaacgaa 289921 gtacagcaat ttttagataa agtgattcga ttagagagag gagaaaaagg cggatggaaa 289981 tgtttgactt ggaattcatg cgacgagctt ttctagcagg cggcatgatc gccgtcatgg 290041 ctccgatact aggagtgtat ctcgttctca gaagacaggc cttaatggct gacacacttt 290101 cacatatctc attgtcaggt gttgccatcg gcttttttct cagcaccaat ataaccgcag 290161 caagcatagt cgtcgtgacc atcggcgcga tcggaattga atacatgcgg cgggcgtatc 290221 ggacttattc agaagtgtcc attgccatct taatggcagc tggtttgtcc ttcgcgatgt 290281 ttttaatcag cctttccaaa ggcacagcca atatgagcat cgatcaatac ctatttggat 290341 cgcttgtgac agtaaaccag cagcaggtct atattatcag tattatcaca ctgctgatcc 290401 tgctttattt tattgtactg agaaggccgc tctacctgct gacgtttgat gaagctacag 290461 ccaaaacatc gggaatcaat acaaacgttc tctcgttgtc attcagtatt gtcacaggcc 290521 ttgcgatttc agtcattatt ccgatcatcg gggtccttct tgtatcggcc ctgctcgtat 290581 tgccggcagc cttcgccatc agaattgcaa aaggctttaa catggttttc attacagcca 290641 tactcatttc attattcagc gtatttacgg gactgacatc atcctatcag ctcgggacgc 290701 cgccaggtcc gtctattacc ctgctattga tcgttttgct attaatcgga tttgcagttc 290761 agggagtttg gacgtttatc aaaaaagaag ctcagcgcaa aaaaagaagc cgataacatg 290821 aaaagcagtt ttccctaggg aaaactgctt tttttataga aacaattcgg caaggcgctc 290881 ataagattct tttttcgcct caaaatcaaa cacattgcac agaaccatga tttcatttgt 290941 ttcgtagcag cctgtgaggt ctaacagctg ttgtttgaca gtggtgggag aaccgatcac 291001 catccgcttt ctgttttctt ctatgagttt tttatcggac gctgtatagg gatgagcttt 291061 cgcttcctcg atgcttggca cgcggctgtc caagcctttt ccgacgcgaa gaagccacag 291121 atcctggctt aatgcgagtt cttctgcctc ttcatctgtt tttgcgcaaa tgacaaaaat 291181 cgtaaacagt gcggatggat tcgaaaaatg ggctgagggc cgaaagcttt cccggtagat 291241 gcggaatgca ttttctcctc gctcgggatt aatgaaatgc ccaaatacat atccaatccc 291301 ctggtgcgcc gcgcgtcttg cgctgttttc accaagaccg agcacccata gctcgggtgc 291361 cgtaccaata aggggcgccg ctttgattcc ggcatacgga tggtcgggag gaagggaatc 291421 tgttagaaaa taagagacat cctgcagctg tctgttaaat tcggttaagc tttttttcac 291481 cccgtccgtt aatgcaagtc tggtttttgt cgtgccgccg ggggagcgac cgacgccgag 291541 gtcaatccgg tttggataca gggcctcaag ctggcgaaag gtttcagcca ctttaaatgg 291601 gctgtattgg ggcagaagca cgccgcctga tccgacacga atggtgtttg tctgtgctgc 291661 gatgcgggcg atcatgattt caggcgctgt gcttgccagt cctttcgtgc tgtgatgctc 291721 ggcaaaccaa taacgcttat agccccactg ttcgcttaat tgggcaagct caaccgaatg 291781 ctggagagtt gtcacagggc tttctccttt agaaacaggt gcctgatcaa gtatgcttaa 291841 atgaatcaaa aggccgcttc ctttctgtct gtttttagat ggtgacacca gaataggcaa 291901 aatgacttgc ccgcgtcaaa tggtttgttt aagaagcgca ctttatagca tttgcaaatc 291961 atatatcaaa tatggaagtt ttttttcgag gtttttcgtc aattattctt aacttttacg 292021 aaactttgat ataataacaa acgtatatat tagtaattta cggcttattt tccttgtgag 292081 cgtaaaaata aatgtgacta tcttcacatt ttgatgagta ggagtgaatc gtgtggcaat 292141 ttctttagaa aaaggtcaac gaattgattt aacaaaagga aaagccggtc tgtcaaaatt 292201 gatggtcggt ctcggctggg acccagtgtc ctcaggcgga ggattcttca gcaaactgct 292261 tggcggaggc ggtccgaata tcgactgtga cgcttcagtg ctgatgctgg aaaacggaaa 292321 attcaccgat aagaaaaacc tgatttattt cggcaacctg aaaagccgct gcggcggtgt 292381 acagcataca ggcgacaacc tgacgggtga cggtgcgggc gatgacgagc aaattatgat 292441 agatttagat aaagtgcctg gaaacatcga taagcttgta tttgtagtga acatttacga 292501 ttgtgtcaga agaaaacaag atttcggcat gattcaaaat gcgtttatcc gcgtagttga 292561 tcaatctaat cacgaggaaa tgctcaagta caatttgaga gacaattacg ccggcagaac 292621 aagcctgatt acagcagaaa tctaccgcag cggcagtgag tggaagtttg cggcggtcgg 292681 tgaaggcaca aacgatacga gattagaaga tattatcagt cgatacgtat aaaagaaaag 292741 gagtggatga aacatgacaa tttcattggc aaaaggacaa aaagtagatt taacaaaaac 292801 aaatccgggt ctttcaaagg ttgttgtcgg tttaggctgg gatacgaaca agtatgacgg 292861 cgggcacgac tttgatcttg actcaagtgt gtttctgtta gacgccgcgg gcaaatgcgc 292921 gtcaccaaac gactttattt tctacaacca gcttgaaggc ggcaacggtt cagtcgttca 292981 ttcaggcgac aacctgactg gtgctggcga aggcgacgat gagaatgtaa aagtaaatct 293041 cagcgctgta ccggcaaaca ttgataaaat ctcatttgtt attaccattc acgatgcaga 293101 agcgcgcagc caaaactttg gacaagtatc aaacgcgttt gtccgcatcg taaatgaaga 293161 aacaaatgaa gagctcatcc gttacgatct tgcagaagat ttctctattg aaacggcaat 293221 cattgcaggg gagctttaca gacataacgg cgagtggaaa ttctcagcaa tcggctcagg 293281 ctaccaaggc ggccttgccc gcattgcaac agactacggt ttgcaagtcg gttaagacaa 293341 atacgaagag cagaaaggag agaggcagta tggccattca attatcaaaa ggacagcgca 293401 ttgatttaac aaaaacaaat ccgggactga ctaaagcggt gatcggctta ggctgggata 293461 caaacaagta ctccggcgga cacgattttg acctggatgc ttcggccttt ttagttgatg 293521 cgcatgataa ctgcgtaaat gatctcgatt tcgtcttcta taataacctt gaacatccga 293581 gcggcggtgt catccatacg ggtgacaacc gcacgggtga gggcgacgga gatgatgagc 293641 agattatcgt tgatttctca aaaatccctg ctcacattga gaaaatcggc atcacagtga 293701 ccattcacga cgctgaagca cgcagccaaa actttggaca agtttccaat gcatttgtcc 293761 gcgttgtgga tgaagaaacg cagaatgagc ttcttcgctt cgatttggga gaagacttct 293821 ccattgaaac agctgttgtc gtttgtgagc tttacagaca cggcggcgag tggaaattca 293881 atgcaatcgg cagcggattt tccggcgggc tggctgcatt gtgccggaat tacggtttgc 293941 aagtgtaagc gagtgacaaa tagagaagtc accgtttcaa attataggag gaaaaaactt 294001 ggacttttta catcatattt tgtctacgta tgcttcattt ttcgattgga aaatgtgggg 294061 ggaagttctg actgatcctg tttcctgggg tttgatcggt tcccttgttg ttctggaagg 294121 ccttttatcg gccgataacg cgcttgttct tgcggtcatg gttaaacacc tgccggaaaa 294181 acagcggaaa aaagcgttaa cgtatggttt gtttggagct tatattttca ggtttatttt 294241 catcgggctc ggtatgcttc tcattaaatt ctggtggatc aaggtgcttg gcgcgcttta 294301 cctggcttgg ctcgtcatta agcacttctg gataggcgaa aaagaagagg aagcggacgg 294361 catgaagaaa aactcttgga tggtccgcac gttcgggatc ttctgggcga ctgtcatttc 294421 agtagaatta atggatcttg ccttctctgt ggacagcatc ctggccgcgt ttgcagtatc 294481 tgaaaaagta tgggtgcttc tgattggcgg tatgcttggt attttaatga tgcgtacagt 294541 ggcaaaagtg ttccttgtgc tgattgataa aattcctgag ctggaaaaca cagcattcgt 294601 cttaatcggc attatcgcgc tgaaaatggc ggggagcgct ttccattacg aaatgccgca 294661 ctctgtattc ttcattatca ttatcgctgc atttgcggta acattgatca ttcactacat 294721 caataaacaa aagcaggtgc gcgaacaaac agccgcttca aaagaagaat aaaacaaaac 294781 aaggagggag gttcaatgtc cttccttttt tgttaccgaa atatcgtttc aatgacaaac 294841 cggaaaggag gatatgatga gacaagaaga actaaccatt cataaagcac ttccggctga 294901 tggcgattgg aaaagcctgc tgtttcagcc attgccggag cgggatcact atgaaactgc 294961 acaaggcctt tctttttctc gtcttgccgg tcagatattg ggcacgccta ttgatgagac 295021 ggactactat aacgagctgt atgagctgtc tgtaaacgac cgcataacga ttttgagtga 295081 aacgcttgat aaaacaatcg aaccggaaac atttcaaaag cttcagcata ttcattccat 295141 caatcagaaa gaaaaagggc tgtcagtcag ccgctttgtt gcctttctgg acggggaaaa 295201 gctgattgcg aagcactcaa atcccttgat gcaccgccat ttaagaaaag cgttgatgac 295261 gcttttacat acctttgcgg acagtcatga aaaggggctg aatcatcctg attttcgcag 295321 agtgctgctt gatgtctcga agttttcctt aaaccatctg aacccttggc tggaaaaaac 295381 cgatatagag cgggagatgc cgaaggttgt ttggtatgga gatgcgacga aaagccagct 295441 ctatttctta tattatctga tgctggtcgg ctgtgatgta ctgctgttcc atccggcggg 295501 aacggatcag ctggcgcttg tcgacccgaa gcaggagctc ggttttacgg aaaagctccc 295561 ggatgtttcg gagcttcagc cgtttccgaa agaaaaacca gaccggaaat caacagtggc 295621 ttaccgctca acaaaggaaa ttgaacatgt gctgaatcac gaggaatcca tgctatataa 295681 gccgtggcag ttcagagatc acacaccggt gtccgttacg ctgaaaacga cctatgatga 295741 attgttttta atcacgaaag aacgcgcctt tattcggccg aatttcaaag ctgataaaca 295801 ttccattgag attccgaatg tattcgccaa aattatgggc gtgtcgaaag acaataagga 295861 atattggaac aggcttcata ctctagcgga ttatcaggaa acagaaatgg tcagaagctt 295921 tccatttaca gaagaaataa agtcgaacta tcaatttcac tacagccacg cacttgatca 295981 agaagggaac attgatccgg acaagctgat ggcaagcaat gtgtggcagt acaaacagct 296041 gccggcgggc gttcagactg ccattgccaa aacgatttcg agaatgtgca ggtacccgcg 296101 gcttaaagcc ttgcatcagg aacaagtcaa ggatgttcaa atctatttgt ttaaacaaac 296161 aacaaacctg cctgctaatc tgctgaaatt gattcaaatg ttcgactatg cgcaaaccgt 296221 tccgaaactc gttttatatc atacggaaat gagcggcgga ctcacgcgtt cggatgctgc 296281 cgccctgctg ttcctgaatg aaatcggaat cgatatcatc atttataatc cgcccggaca 296341 ccaagatatt gagcagttta ttgaagagga tcagtatgat atccactggc tggatgacat 296401 ggtgtttcag caggactaca aagagccttc gcttgtgaaa aggctcttca gaaccattac 296461 ccaaaaataa ggagagaaga aaagcatgac aacagaaaat caaaatccgc ttgttctcga 296521 taaaaatgaa gagatttccc agcaaaaagc tgacgatatc cgtcttcagc tccgtcagga 296581 accagaagtg aagcggcttg ctcaacaaat tgacgtcaaa aaccaaatgg agctgcttga 296641 gtacggcaag gagccggccg ttgaaatatc caagttctct gaccgcatct tggggatgat 296701 gaaaacaaca agcgtgacag actccggcac aatgctgact cagcttggga aaatcatgga 296761 ccgcttcgac aaaaatgatt ttgatgagcc aaagggatta atggcgaaaa ttttcaaacg 296821 cggcggcagc atgattgaaa aaatctttaa aaagtatcag acgcttggcg gagagattga 296881 aaaaatccac gttgagattt caaaatacaa agatgagatg acgaagacga actacacgct 296941 cgatgaaatg tatgaaaaca atatcaaata ctatatggag cttgaaaaat acgtcgttgc 297001 cgggcagatg aaactggaag agatgcagtc gatccttcct tcatatgagg aaaaagcggc 297061 aagcgggaac cagctggcgc aaatgcagct cgatacgttg cgcaacggca ttcaggcgct 297121 tgaggaacgg gtgtatgatc ttgacatggc acggatggtg gcgcttcaaa ccgcacctca 297181 aatccgtctc ctgcagcgag gaaatgcaaa gctgatcggg aaaatcaact ccgcgtttat 297241 cattaccatt ccgattttca aaaacggcat tattcaggct gttacggtaa agcggcaaaa 297301 gcttgtggct gattccatga gcgagcttga ccgccggaca aacgagatgc tgaaacgaaa 297361 tgctgaaaac atctcgagcc aaagtgttga aattgcgaga atggccggca gaccgagcat 297421 agatattgaa acgattgaat cgtcttggaa cacgattgtc agcggcatgc aggaaacaaa 297481 acaaatcgaa gaagaaaaca agcgcctccg cgaagacggc gcgagacgaa ttgcccagct 297541 tcaggataat attaaaaaag cagcattgca gcaataataa aaaccccgct tgtggaacat 297601 aagcggggta tttcaattac atcatttagt taatgacaat gtgtaaagac aggtgtaaac 297661 ttaaacggta atcattttgc atatcagagg tgttggcaat gggaaaacaa cagcctatat 297721 cccagcgtaa actgctgggc gtcgccggtt tggggtggct gtttgatgca atggatgtcg 297781 gaatattatc gtttattatc gccgcgctcc atgtagagtg gaatctgtcg cccgaagaaa 297841 tgaaatggat cggaagcgtc aattccatcg gcatggctgc gggtgcgttt ttgtttggtt 297901 tgcttgctga tcgaatcggc cgcaaaaaag tgttcatcat caccctttta tgcttttcca 297961 tcggaagcgg catttccgct tttgtgacga gcttatcggc atttctaatc cttcgtttcg 298021 tgattggtat gggacttggc ggcgagcttc cagtcgcttc aacactcgtt tcggaagcgg 298081 ttgtgcctga aaagcggggc agagtgattg tgcttttgga aagcttttgg gccgtgggct 298141 ggctcgcagc ggccttgatt tcttactttg tgataccaag cttcggctgg caggctgccc 298201 ttctgttaac tgcgctgact gctttttatg cgctgtacct gcggacgagt ctacctgatt 298261 cgccgaaata tgaatcgctt tctgccaaaa agaggtcgat gtgggagaat gtaaaaagcg 298321 tctgggcaag acagtatata cggccgacgg tgatgctgtc gatcgtttgg ttctgtgtgg 298381 tgttttctta ttacggcatg ttcctatggc tcccgagtgt catgctgctg aaaggcttca 298441 gcatgattca aagctttgaa tatgtcctgc tgatgacgct tgctcagcta cctggctatt 298501 tctctgccgc atggctgatt gaaaaagcgg gccggaagtg gatactcgtc gtttacttga 298561 ttggcacagc aggaagcgcc tatttcttcg gaacggcgga ttccttaagt cttctgctta 298621 cggctggagt gctgttatcg tttttcaatc tcggtgcgtg gggcgtgctg tatgcttata 298681 ccccggagca atacccgact gcgattcgag caacaggttc aggaacgaca gcagcgtttg 298741 gaagaatcgg cggcatcttc gggcctttgc tcgtcggaac cctggcagcc cgtcatattt 298801 cgttttcggt catcttttca atcttttgca ttgcaatctt acttgcggtt gcttgtattt 298861 tgattatggg gaaagaaacg aaacaaactg agctagaata ggaaaagcac ctcttaaaag 298921 aggtgctttc agcgtgtcga caaaccctcg cattcgttgt caggactgcg cttcggtgct 298981 caatgcgaag tggatcaacg gctaaattct caggcgtcct gcctaaacgc cgtcgtcatc 299041 acatcctgtg aatgtccgct cctatgctcg tccttcctag acttcaaggg ttttcaatca 299101 cgctgaaaag attttgtcaa caatctgagg cacctcttga atgaggtgct tttttacaat 299161 tgcgcccggg ctgtggattg gcgtttcccg gttttactga ttgtctggta gagcgtcata 299221 gaaagtatga acagaatggc agtaaatcct gtgacagctc cgaaatgctg tgtgctttga 299281 tataaaaaac ctgcaatact tgtaccgaca gtggttccgg catacatagc ggcattggaa 299341 agggaagcga tggttcctcg cgcatttggt gcaatggatt gaaagacacc catcattaac 299401 ggaaagatga tgccagctgt aaagaacgtg agaaaaaagc cggcttctac taaaaacaag 299461 tttggaaaga acggaagagc gaaatagaga gcgcccatta gcagcatccc gctgatcagt 299521 gttttaaaca tgcccagctt ttctgaaacc cggctgccga taaggctccc gagcatattt 299581 cccagtccga gtacaagcat agctgcgcca atttgtgaca cggttaaatg ataatccgcg 299641 gaaagccaag tacccagaaa gctgaacgat gcgaagtttc cggtttgaaa cagaaaatag 299701 gcaagcagaa tgaccgatgt tttcggcaat gaaaaaagct cccgataggg gttgacaatt 299761 gatgggcgcg ccaatggttc agaaggccgg atgccaggca tgaccgccgc caggatcaat 299821 agaagaataa gcgagcacgc tgacaaaacg aaaaatggcg tatgccatgt aaaggaagcg 299881 agaaaccctc caataggaag tccgagcatt tgtgaagcgg ccaaacctgc tgtcgcaatc 299941 cccatgcctt ttatgatctg agaaggctgg acaatgactg ggatggacgc ccaaatttga 300001 ggcgtcacaa acgcagcgct aacgcctgcg gcaaaacgga acaggcacat ggcggcaaaa 300061 gagggagcga tgccgcataa aaatgtggat acgataaagc ctgcaagtcc ccacagcatg 300121 actgttttcc tgttcagccg gtctgagatt gggcctgcaa tgaaagcgaa gagtgcataa 300181 ccgagtgcat aagcactgac catccagcct gacaaatcag tagagacatg aaactgatcc 300241 tgtaaaaggg ggagaagcgg cgaaagcaaa aaggtatccg tgccaatgac aaacatgaca 300301 ctgaagaaaa gccaaatgcg attcaaattt tatcactcct attgttttat aactttaaaa 300361 ctatgaaaca gatatgtata gagaaaaccc tttgttagag ggtttccaaa aagccaggca 300421 ggtatgtttg aaatgtgtct tcacgcagac tgacgtattt tgtccgcgaa tctttccggg 300481 ttgccgtcaa tcccgcttca cgcagcgttt taaaatgata agatgccgtg gttttgacaa 300541 tattgcactt ttcacctact tcaccgcagc tgagttcttt tccgctgaca taaagcgtac 300601 gaataatggc aagccttgat tcatcagaca gtgctttaaa aatttgcgct ctgatttgat 300661 catctgattg tttcatagtc atgaaactat aatacataat gggtgttgaa aaagcaactt 300721 atttttccag taaaggagca ggaagtcata agaggaagga ggaattcaat tccaataaaa 300781 gcgttttcaa ctaaaggtag gagaaaaatc acccgtaaaa tacaatcata taggaggatt 300841 acagagcatt tagaagcata aataagatca tgtggtcaca tggatgttta taaagaaatg 300901 gtacagaata aaagagaata tgctgtttgt gtgggaagtt acataaatgt tacggtaata 300961 aagattgctt aatatggagg gaaaatatga gtgtagatga gaaaccaatt aagataaaag 301021 tcgagaaagt ctctaagatt tttgggaaac aaacaaagaa ggcagttcaa atgcttgcca 301081 acggaaagac aaaaaaagag atcctgaaag caaccggatc aaccgttggg gttaatcagg 301141 cagattttga agtatatgat ggtgagatat ttgtcatcat gggtctatca gggagcggta 301201 aatcaacttt agtacggatg ttaaaccggc ttattgaacc gactgccgga aatatttaca 301261 ttgatggtga catgataaca aatatgtcaa aagaccagct ccgggaagtc cgccggaaaa 301321 aaatcagcat ggtcttccaa aagttcgctc tgtttccgca cagaacgata cttgaaaaca 301381 cagaatacgg actggagctt caaggtgtag acaaacaaga gcggcagcaa aaagcgcttg 301441 agtctcttaa gctcgttgga ctggaaggat ttgaacacca atatcccgac cagctttccg 301501 gcgggatgca gcagcgtgtc ggccttgccc gcgcgttgac gaatgacccg gacatccttc 301561 tgatggacga agcgttcagt gcgctcgatc cactgattcg taaagatatg caggatgagc 301621 ttcttgatct tcacgataat gtcggaaaaa caattatctt tattacgcat gacttggacg 301681 aagcgttgcg gatcggcgac agaattgtcc taatgaagga cggcaacatc gttcaaatcg 301741 gcacgcctga agaaatcctg atgaatccat ctaacgaata tgttgagaaa ttcgtcgaag 301801 atgttgattt gtctaaagtc ctcacagcag gccacattat gaaacgcgct gaaacagtgc 301861 ggattgataa agggcctcgc gtagcattga cactgatgaa aaaccttgga atttcttcaa 301921 tttatgcagt ggataaacaa aagaaattat taggtgttat ctatgcgtct gatgcgaaaa 301981 aagcggctga gtctgatttg tcacttcaag acatcttgaa tacagaattt acgactgtac 302041 cagagaatac gtatctgact gagatttttg acgttgtgtc cgatgcgaat attccaattg 302101 cggttgtgga tgagaagcaa agaatgaaag gaattgtcgt aagaggcgcg ctgattggcg 302161 cacttgccgg caataacgag tatatcaatg ctgaaggcac taacgaacaa acacaagatc 302221 cttctgcaca ggaggtgaaa taagatggat agactgccta gaataccttt agcagatatt 302281 attgaccgtt ttgttgactg gattacgatg acgtttggcg gattcttcga cggaatcgct 302341 aacggattgg ccgcttttgt aaatggaatt gtcaccggtc ttggatttat tccatctatt 302401 ttgttaacga ttattttcgc cgcacttgcg tggtggatca gtacaagggg aattgcgtta 302461 tttacgttga ttggattcct cctgatcgat tatttaggat attgggaccc aatgctgcaa 302521 acattggcgc ttgttttgac atctgtgatt atttcgattg tggtcggggt tccgatcgga 302581 atttgggcgt ctcagaaaga aacggttcgc cgtattgtaa cgccaattct tgatttaatg 302641 cagacaatgc ctgctttcgt atatctattg ccggcgattt tcttctttaa catcggtgtt 302701 gtgccgggtg ttgttgcatc tgttatcttc gcgatgccgc cgacaatccg catgactgtt 302761 ctcggtatta aacaagtgcc ggcggatttg attgaagcga ctgaggcatt cggttctaca 302821 acagctcagc gtttgtttaa agttcagctc ccgcttgcga caaaaacgat tttggccggg 302881 atcaaccaga gcatcatgct tgcgttatca atggttgtta tcgccgcaat ggtcggtgca 302941 ccgggacttg gttctgaagt atacagtgcc gttacacagc tgaaaaccgg ggtcggagta 303001 gaggccggta tcgccatcgt tatcgttgcc attaccctgg accgtattac tcaaaatatt 303061 aaagtgaaga agaaaagcag ggggaatgcc tgatgcttaa aaaaatcata ggcatcggcg 303121 tttccgccat gctggcgctc tcacttgcgg cttgcggttc agaaaacgat gaaaatgcat 303181 ccgcagcaga acaagtgaat aagaccatca tcgggattga ccccggttca gggattatgt 303241 ccctgactga caaagcgatg aaggattatg acctgaatga ctggacattg atttcagcgt 303301 caagtgctgc gatgaccgct acgcttaaaa agtcatacga ccgtaagaaa ccgattatca 303361 ttacaggatg gacaccgcac tggatgttct ccagatataa gctgaaatat ctcgatgatc 303421 cgaaacaatc ttatggcagc gcagaggaaa tccatacgat cacacgcaaa ggcttcagca 303481 aagagcagcc gaatgccgca aagcttctga gccagtttaa atggacgcag gacgaaatgg 303541 gcgaaatcat gatcaaggtg gaagaaggcg agaaacctgc caaagttgct gctgagtacg 303601 tcaataaaca caaggatcag attgccgaat ggacaaaagg cgttcaaaag gtgaagggag 303661 acaaaatcaa ccttgcctat gtggcgtggg acagtgagat tgcaagtaca aacgtcatag 303721 gcaaagtctt agaagacttg ggctatgagg taacacttac tcaggtagag gctgggccga 303781 tgtggactgc aattgcgacg ggaagtgcgg atgcatccct ttccgcatgg ctgccgaata 303841 cccataaagc atacgccgct aaatataaag gcaaatatga tgatattggc accagtatga 303901 ctggtgtgaa gatggggctt gttgttcctc aatatatgaa aaatgtcaac tcaattgaag 303961 atttgaagaa gtaatcaaaa aagcagcctg tgtcaggctg ctttttttgc gttaagaagc 304021 gttagcggca gcaagtgatt ccgccttctg aaatgttttg agcacggcgt tcgccaaaat 304081 atgaatgccg gtaaacatcg catttctgtc aaaggtcatg tgcggatgat ggagccccgg 304141 ctggagcccg cagcctagtc cgagcatcgt tgttttcaga ttcggcacct tcacggcgta 304201 aaaatggaaa tcctcgccgc cggtggtgac aagcgggtca tcaagccgct cagccccgat 304261 gatttccgta atggcttctg ccatgatcgc ttcagcttct ttattttgtg ttgccgcagg 304321 aaggctgtgt tctttgtgca gctcgatctt tgcgccaaat gcagcggcgg ccgcttcaca 304381 ggctctttct gtttcggcga ttaatgcctc catggcttca ttggtctgtg cgcgcaaatc 304441 aaggctgaac gatgcttttc ctggaatgat gttagagctt tcaccgccgg cttgcagttt 304501 tgtcattttg acggtatgcg ggatttgcgg gtcaatatga atgagtccga gcttgtgtac 304561 aagaaatgcc gcaatttcaa tgctgttttt cccgaggtgc ggacgggcgc catgagcctc 304621 ttccccgatg atcgttccct caatgtgctg gcttgatccg tgcagaatag aaggagcgca 304681 gcggccgttc tgtgtttcct ggatcggacg gacgtgaacg ccatacaaat agtcgatatc 304741 atcaagcacg ccttcttcta tcattttcaa ggcgccgccg cctttttctt ctgccggctg 304801 aaagataaaa cggattgtgc ccttcggaag ctcaggttgt ttttttagca gcattaacgt 304861 gcccaatgcc attgtcatat gtgaatcgtg tccgcaggaa tggttggcgc gaaatgtgcc 304921 gttaacctcc tgccacagcg cgtcaatatc agcgcgtacc gctacaacag gtgagcctga 304981 gccgatttcg ccgacaaccc cggtgcagtc tgaaaacgtg cgcgtccggc accctaaatc 305041 ctcaagcttt tgtttcaaaa atgaagttgt ctcatattcc ttccagctga cttcagggtt 305101 cgcgtgcaga tgctcgaaga tgtccataat ggtttgtttc atttcttctg aaagcttttg 305161 catggtaaga aatacctcct tctatcagaa tgaattttta ccttctttac tttatttata 305221 ttgaaacagg aagataggct gtatataata tagcacatat tgctactatt cagaataatt 305281 aatattttca aacagagggg atggatcgaa atatgagtat gccagcagcc gaaacacagc 305341 ctaagaaaaa acgtatgaca tttaaaatgc ctgacgccta tgtcctctta tttatgattg 305401 ctttcatttg cgcaatcgct tcatatattg tgccggcagg tgaatttgac cgcgtgacaa 305461 agggggatgt cacgaccgct gttccgggaa gctatcattc aattgaacag tctccggtca 305521 gattgatcag cttttttact tctctacagg atggaatggt tggatcagca cccatcatct 305581 ttctgatttt attcacaggc ggcaccattg ctattctaga aaaaacgggt gccatcaatg 305641 gcctgattta caatgtcatc agcaaattcc gcacaaagca attattattt atttgtattg 305701 tcggcgcatt gttctccatt ctcggaacaa ccgggattgt cgtgaattca gttatcggtt 305761 ttatccccat cggcctcatt gtggcacgat ccttaaaatg ggacgcagtc gcgggagccg 305821 ctgttatata catcggctgc tacgctggat ttaactccac catattatca ccgtcaccgc 305881 tcggtttatc acaatcaatc gcggagctcc ctcttttctc aggaatcggc ctgcgagttg 305941 tgatatacat atgctttttg ctgtcttcta ttatttatat ctatttgtat acgagaaaat 306001 taaaaaaatc aaaagatgcc agtgtgttag gaacagattg gttccctgcg gcaggaatgg 306061 gcgaagccgg taaagaagaa gatcagtcag tgccgtttac cgttcgccat aagctgattt 306121 tggctgtggc gggactctca cttgtcggat ttttatacgg cgctttgaag cttggctggt 306181 cagattccca aatggctgcg acatttattt ttatttctgt ccttgccggt ttaataggcg 306241 ggcttgcggc gaacgatatt gccaaaacct tcattacggg ctgccaaagt cttgtatacg 306301 gggcgctgat tgtcgggatg gcacgaagca tttccgttat ccttgaaaat ggaaagcttc 306361 tcgatactgt cgtcaatgct ttggcttcac ttttggatgg attcagcccg attgctgggg 306421 caatcggcat gtatatcgcc agtgcgctgc ttcattttct catctcttca ggttctggcg 306481 aagccgttgt atttattcca atcctggcgc cgctcgctga tttgatggga atcacgagac 306541 aggttgcggt tgaagcggtt atgcttggag aaggggtcgt caactgtgtg aacccgacat 306601 ccggcgttct catggcggtg cttgccgcca gcggtattcc gtatgtcaag tggctgcggt 306661 ttatggtgcc gcttgctctg atttggttct tgatcgggct tgtctttatc gtgatcggag 306721 tcatgatcaa ttgggggccg ttttaacgat tgctgcccgc cggcttgtac ggcgggcttt 306781 tgagttattc attgcagaag cgcaggctgt tattgtaaca tgtaagccat aagccattcg 306841 taaaagtgcg ggaggaaggt catgaataat ctgcgtaata gactttcagg cgtgaatggg 306901 aaaaataaga gagtaaaaga aaaagaacaa aaaatctggt cggagattgg gatgatagcg 306961 ggagcatttg cgctgcttga tgtgatcatc cgcggcatta tgtttgaatt tccgtttaaa 307021 gaatgggctg caagccttgt gtttttgttc atcattatct tatattactg catcagggct 307081 gcggcatccg gaatgctcat gccgagaata gacaccaaag aagaactgca aaaacgggtg 307141 aagcagcagc gaatagaatc aattgcggtc gcctttgcgg tagtggtgct tacgatgtac 307201 gacaggggga ttccccatac attcttcgct tggctgaaaa tgattcttct ttttatcgtc 307261 tgcggcggcg ttctgtttct gcttcggtat gtgattgtga agctggctta cagaagagcg 307321 gtaaaagaag aaataaaaaa gaaatcatct tttttgtttg gaaagcgagg gaagcgttca 307381 cagtttcggg cagctttttt tataggaaca ttgatttgta ttcactctgc caagttgttt 307441 tgatagagtg attgtgataa ttttaaatgt aagcgttaac aaaattctcc agtcttcaca 307501 tcggtttgaa aggaggaagc ggaagaatga agtaagaggg atttttgact ccgaagtaag 307561 tcttcaaaaa atcaaataag gagtgtcaag aatgtttgca aaacgattca aaacctcttt 307621 actgccgtta ttcgctggat ttttattgct gtttcatttg gttctggcag gaccggcggc 307681 tgcgagtgct gaaacggcga acaaatcgaa tgagcttaca gcaccgtcga tcaaaagcgg 307741 aaccattctt catgcatgga attggtcgtt caatacgtta aaacacaata tgaaggatat 307801 tcatgatgca ggatatacag ccattcagac atctccgatt aaccaagtaa aggaagggaa 307861 tcaaggagat aaaagcatgt cgaactggta ctggctgtat cagccgacat cgtatcaaat 307921 tggcaaccgt tacttaggta ctgaacaaga atttaaagaa atgtgtgcag ccgctgaaga 307981 atatggcata aaggtcattg ttgacgcggt catcaatcat accaccagtg attatgccgc 308041 gatttccaat gaggttaaga gtattccaaa ctggacacat ggaaacacac aaattaaaaa 308101 ctggtctgat cgatgggatg tcacgcagaa ttcattgctc gggctgtatg actggaatac 308161 acaaaataca caagtacagt cctatctgaa acggttctta gacagggcat tgaatgacgg 308221 ggcagacggt tttcgatttg atgccgccaa acatatagag cttccagatg atggcagtta 308281 cggcagtcaa ttttggccga atatcacaaa tacatctgca gagttccaat acggagaaat 308341 cctgcaggat agtgcctcca gagatgctgc atatgcgaat tatatggatg tgacagcgtc 308401 taactatggg cattccataa ggtccgcttt aaagaatcgt aatctgggcg tgtcgaatat 308461 ctcccactat gcatctgatg tgtctgcgga caagctagtg acatgggtag agtcgcatga 308521 tacgtatgcc aatgatgatg aagagtcgac atggatgagc gatgatgata tccgtttagg 308581 ctgggcggtg atagcttctc gttcaggcag tacgcctctt ttcttttcca gacctgaggg 308641 aggcggaaat ggtgtgaggt tcccggggaa aagccaaata ggcgatcgcg ggagtgcttt 308701 atttgaagat caggctatca ctgcggtcaa tagatttcac aatgtgatgg ctggacagcc 308761 tgaggaactc tcgaacccga atggaaacaa ccagatattt atgaatcagc gcggctcaca 308821 tggcgttgtg ctggcaaatg caggttcatc ctctgtctct atcaatacgg caacaaaatt 308881 gcctgatggc aggtatgaca ataaagctgg agcgggttca tttcaagtga acgatggtaa 308941 actgacaggc acgatcaatg ccaggtctgt agctgtgctt tatcctgatg atattgcaaa 309001 agcgcctcat gttttccttg agaattacaa aacaggtgta acacattctt tcaatgatca 309061 actgacgatt accttgcgtg cagatgcgaa tacaacaaaa gccgtttatc aaatcaataa 309121 tggaccagag acggcgttta aggatggaga tcaattcaca atcggaaaag gagatccatt 309181 tggcaaaaca tacaccatca tgttaaaagg aacgaacagt gatggtgtaa cgaggaccga 309241 gaaatacagt tttgttaaaa gagatccagc gtcggccaaa accatcggct atcaaaatcc 309301 gaatcattgg agccaggtaa atgcttatat ctataaacat gatgggagcc gagtaattga 309361 attgaccgga tcttggcctg gaaaaccaat gactaaaaat gcagacggaa tttacacgct 309421 gacgctgcct gcggacacgg atacaaccaa cgcaaaagtg atttttaata atggcagcgc 309481 ccaagtgccc ggtcagaatc agcctggctt tgattacgtg ctaaatggtt tatataatga 309541 ctcgggctta agcggttctc ttccccattg agggcaaggc tagacgggac ttaccgaaag 309601 aaaccatcaa tgatggtttc ttttttgttc ataaatcaga caaaactttt ctcttgcaaa 309661 agtttgtgaa gtgttgcaca atataaatgt gaaatacttc acaaacaaaa agacatcaaa 309721 gagaaacata ccctggaagg atgattaatg atgaacaaac atgtaaataa agtagcttta 309781 atcggagcgg gttttgttgg aagcagttat gcatttgcgt taattaacca aggaatcaca 309841 gatgagcttg tggtcattga tgtaaataaa gaaaaagcaa tgggcgatgt gatggattta 309901 aaccacggaa aggcgtttgc gccacaaccg gtcaaaacat cttacggaac atatgaagac 309961 tgcaaggatg ctgatattgt ctgcatttgc gccggagcaa accaaaaacc tggtgagaca 310021 cgccttgaat tagtagaaaa gaacttgaag attttcaaag gcatcgttag tgaagtcatg 310081 gcgagcggat ttgacggcat tttcttagtc gcgacaaatc cggttgatat cctgacttac 310141 gcaacatgga aattcagcgg cctgccaaaa gagcgggtga ttggaagcgg cacaacactt 310201 gattctgcga gattccgttt catgctgagc gaatactttg gcgcagcgcc tcaaaacgta 310261 cacgcgcata ttatcggaga gcacggcgac acagagcttc ctgtttggag ccacgcgaat 310321 gtcggcggtg tgccggtcag tgaactcgtt gagaaaaacg atgcgtacaa acaagaggag 310381 ctggaccaaa ttgtagatga tgtgaaaaac gcagcttacc atatcattga gaaaaaaggc 310441 gcgacttatt atggggttgc gatgagtctt gctcgcatta caaaagccat tcttcataat 310501 gaaaacagca tattaactgt cagcacatat ttggacgggc aatacggtgc agatgacgtg 310561 tacatcggtg tgccggctgt cgtgaatcgc ggagggatcg caggtatcac tgagctgaac 310621 ttaaatgaga aagaaaaaga acagttcctt cacagcgccg gcgtccttaa aaacatttta 310681 aaacctcatt ttgcagaaca aaaagtcaac taaccgcaac tttagagtaa agggctgatt 310741 gtcaatgtgg gagcagttgt atgatccgtt tggaaacgag tatgtgagcg cacttgtggc 310801 gctcactccg attctctttt ttcttttggc tttaactgtt ttgaaaatga aaggcattct 310861 tgcggcattt cttaccctag ccgtcagttt cttcgtctcc gtttgggcat ttcatatgcc 310921 ggttgaaaaa gcgatttctt ctgttttgtt aggaatcggg agcgggctgt ggcccattgg 310981 ctacatcgtc ctgatggcgg tgtggctgta taaaatcgcc gtgaaaaccg ggaaatttac 311041 cattattcgg tccagcattg ccggcatttc gcctgaccaa cgattacagc tattattaat 311101 tggtttttgt tttaacgcgt ttttagaagg cgcggccggt tttggtgttc cgattgcgat 311161 tagtgcggcg ctgctcgtcg aacttggttt taaaccgtta aaagcggcgg cgctctgctt 311221 gattgcaaac gctgcctccg gagcctttgg ggcgattggg attcctgtca tcacaggggc 311281 gcagattggt gatttgtctg ctcttgagct gtctcggaca ttaatgtgga cactgccgat 311341 gatctcattt ttaataccat tcctgcttgt attcttatta gaccgaatga aaggaatcaa 311401 acagacatgg cccgctcttc tggttgtgag cggtgggtat acagcggttc agacactgac 311461 aatggcggtg ctcgggccgg aattagcaaa cattttggcg gccttattca gcatgggcgg 311521 gcttgccctc ttcctccgca aatggcagcc gaaagagatt taccgcgagg aaggggccgg 311581 cgatgctggt gagaaaaagg cataccgtgc cgctgacatt gcgaaagcgt ggtctccttt 311641 ctacatttta actgcggcga tcaccatctg gagccttcct gccttcaaag cgcttttcca 311701 agaaggcggg ctgttatatc aatcaacgct cctgttcaaa atgccttttc tgcatcagca 311761 aattatgaaa atgccgccga ttgcgccatc tgccatgccg ttagatgcag tctttaaagt 311821 tgatctgctg tcagcgactg gtacagcgat tttagcggcg gtcatcgtga cagggctgtt 311881 cagcaaaaag ttctcctctc gggatgcctt tgcttccttg aaggagacgg gaaaagagct 311941 gtgggtgccg attatgacga tctgcttcgt gatggggttt gccaatctgg ccaacttcgc 312001 agggctcagc tcttcaattg ggttagcatt ggcgaaaaca ggagacctgt tcccgtttgt 312061 cagtcctgtt ctcggctgga ttggcgtgtt catcaccggt tctgttgtca gcaataatgc 312121 tttgttcggc catttgcagg ttgtcacggg agcgcagatc ggtgcgggtt cagatttgct 312181 gttagccgca aatacggcgg gcggtgtcat ggcgaaactt gtttctcctc aatctatcgc 312241 catcgctgcc gcagcggtcg gccaaacagg caaggaatct aaactgttta aaaggacagt 312301 ggcgtacagc ctgattctgt tattgatcat ttgtatatgg acgtttattc ttgcaagatt 312361 aggagtgtaa tagaaaaaag cagtacatgc ccagcatgta ctgctttttt tatgttaatt 312421 tgctttcttt gtcatttcgg ctgttgtttt cactctggct tttcccataa ataaaatggt 312481 aaccgccgcg aggacaattg gaatcaaagc gagcaaaaag acatacgtga tacttgatga 312541 catcgcgtca ataatgcgat tcaggatcgc atcaggaatc tgggaacgtg ttcccgcttg 312601 gaatatctcc tgcgggtcgc caatattttg cgcagcgcct gatcccgctg agcctttcat 312661 accgctgaag gcgtcattca gcttgtttgt gaatacgttt gtttgcaccg ttccgaaaat 312721 ggtgacacct aaggtcatgc caaatgatcg caaaaatgaa tttgtagagt ttgccgttcc 312781 ccgaaagcga ggttcaagat cattcatcga tgccgccggc agcagggaga agttaaagcc 312841 tacaccaaag cctgaaatca tcataaagac tgtcagccat acccgtgctg tgtcaggcgt 312901 catattggaa agaagcagca tgccgataaa gaaagctata acagatatca gcatcaaatt 312961 gcggaagctt gccttcgttt ggaagatccc gccgatcatg cttccgatga ctgatccaat 313021 catcatcggc gtcagaatga agcccgcgct tgtcgccgag ctgccgtaga ccgcctgaac 313081 gaaaatcgga ataaataccg ctaaaataat aaatgttccg ccatacagga aagcgagaat 313141 ctgtgctgtg gcaaacaagc ggttcttaaa catccagaaa gaaataatcg gctcttctgc 313201 ttttctctcc acaataaaaa aggcaatgaa gaaaacggcg aatacaataa acagcccgat 313261 gatctgaatg gagttccaat cgtatgtttt gccgccaagc tcaagggcga acatcaggca 313321 tacaatggat acgactaagg taatcgcgcc gccccagtct attttctgct ttctgtgctc 313381 cagagattct ttgtagtagc gaataatgaa aaacaatgac aatgcgccga tcggcacatt 313441 gatgtaaaac acccagtgcc agctgatcga atctgtaatg atcgcgccta agagcggacc 313501 aagaacactg gataatccaa atacagcacc gaacatgccg gacatttttc cgcgtttttc 313561 cggcggaaac aaatcaaaga taatggtaaa ggcaatcggc aggagcgcgc cgcctccgat 313621 cccttgaatg gcccggaaga tgatcagctg attcatcgtc tgggcaatcc cgcataaagc 313681 agaaccgatt aagaaaaaaa taagtccaaa caggaaaaaa cgttttcggc cgtacatatc 313741 ggaaagcttg ccgtaaatcg gcatgccagc cataaccgcc accatatagg atgccgtcac 313801 ccaggcaaat ttatcgaagc ttccaagatc ggctacgata ttgcccatcg cggtggcaac 313861 aatcgtattg tccattgcag acatcaagat gcccagcagg agaccgagga ccacaaattt 313921 ggtggaagcc tgttttgctg ttgttgtgtc catttgttct acctcctctt acttttctat 313981 gtaagttctg atatcatgat aatagtttga ttgttgaata tctcgattat caagataaac 314041 tcgattttat agggaggact gtcagttgtc aacaagaaat tccagaagtg agttggaaaa 314101 gactgctgtt cagctttttc gaaaactggg cacaagaacg gttctgtttc atcaggcagc 314161 cgctcaagct ctcggtctgt ttcccaccga tttgaaatca gctgacattt taaatgaagc 314221 agggccgatg acggccggag agctggggaa aaaaaccggc ctcagcacgg gttccgtcac 314281 ggcgcttgtt gaccggctgg aaaaagcggg gtatgtggct cgtgaaaagg acccgaacga 314341 tcgcaggaga gtcgtaatcg tccctttgac tgcttcgaaa aaacatataa aggatttgtt 314401 ccgtcctctg tctgagtcaa cgatggattt gtgccgcgaa tatacggaag aggagctgga 314461 actcattttc agttttgtag gcaaagctgc cgatattatg gaggaagagc ttgaacgtct 314521 gaaacagtaa gtgaatttgt gcatagcttg gcccgttccc gaataaattg tacaagttac 314581 ataagagaag ggagtacggg ccggtgaaca tttttttgag ctatattgtg ctgggactgt 314641 ccttgtctgc gcctgtgggg ccagtgaatg cggcgcaaat agacaaagga attaaaaacg 314701 gtttttggca tgcatggatt ttcggtttag gcgccatgac agcggatggg ctgtacatgc 314761 tttttatcta tttcgggctg tcgcagttct tgaccgctcc atttgtgaaa acgtttttgt 314821 ggctgttcgg cttttttgtc ctgacctata ccggaattga aacgctgaaa aacgtcagag 314881 aaccgatgga tgtgcgaagc tcgcggggga aaccgtcata caggaaaaca ttcgcatcgg 314941 gttttctcat ttcattgtca aacccattga gcatcctttt ttggcttgga atttacggaa 315001 gcattcttgc gaaaacagca gaggcctaca atatgaatca gcttctaatc tatagctccg 315061 gcatcatgat cggcatttta atctgggatt tctgcatggc tatcacagcc agtacgttca 315121 gaaacctgct tcatgaaaag ctattgagag gattgaccgg aatcgccggt gtatccctcc 315181 ttgtgtttgg cttttacttt ggttatcagg gcatcaaaca gttattgggc tgattcatga 315241 aggacagtca cctgccgctt ccagttttaa tatagtatcc agatgatact ggaggtggat 315301 caatggtgaa tgggatttac accaaaagtt ttctggaacg tattcaggaa gagcttcctg 315361 aatggcaaag aatcgctttt gagctgctgg cagaaactct gggggacgac gcggatacat 315421 ttccgtgcat tcccggacgc caggcgtttc tgactgatca gcttcggatt gcttttgccg 315481 gagatccgcg ggaaaaccgc acagcggagg aactggctcc gttgcttgcg gagtacggca 315541 agatatcgcg ggacacggga aaatacgcat ccctcgttgt gttgtttgat acaccggaag 315601 atttggcgga gcattattcg attgaagcgt atgaagagct gttttggcgc tttttaaata 315661 gactgagtca tcaagacgaa aaagaatggc cggaagacat tccggccgat cctgagcatt 315721 ataaatggga gttttgtttt gacggcgagc cgtatttcat tctgtgcgct acaccggggc 315781 acgaggcaag aagaagccgg agctttcctt tttttatggt cacgtttcag ccaaggtggg 315841 tgtttgatga cctaaatgga tcaactgcat ttggccgtaa catgagcagg ctgatccgat 315901 ctcgtttaga ggcctatgat caggctccga ttcacccgca attaggctgg tacggaggaa 315961 aagataatcg tgaatggaag cagtatttcc tccgtgatga cgaaaaacag gtatcgaagt 316021 gcccgttttc ttatttaaag aacatgttca acaaaatgaa ataaatcaag gactggcagg 316081 gcgatcttta tgaccctgct ttttttgata gatcatggta acgatggcga taatcacgag 316141 aaaacctatg ctgacgaaaa aaccgggccg gcttgatttt tcaaacaatg taccggacac 316201 agctgcagca atcagaacca tcgctaaata aatttgcgtt tttcccatgc cctcgggatc 316261 agtcagcttt ttgctggaga acaggataaa cagccaagtg tataaaagca taagccccgc 316321 agctgttgtc atatgctcat aaatgttttt aggcagcact aacgacaaaa taatggagag 316381 gacaagcccc gcaaacgtca gcccaagtgc cggccagcat atttttttgc cttcctttag 316441 agtaaagcat ttcggcgcgt cgccgtcatc agccattgta caaagcaatg tcgtaaccgc 316501 aaatagcgaa gcgacaaggg tcgagaaccc tgcgatgatg aaaatcccgt taaatatatc 316561 aaggatgatc tcaaggttat atccttttaa tgacgtaatg aacggactgt cctgttcagt 316621 aaacgtgtgt aacggaacca aaagcagagc aagcccgatt gaaatgatat aaataatcgc 316681 cagcgtcgcc agcatcagtt tccctgattt agacgcttcc tcaggttttt ttaagtgaac 316741 cgccatcagc cccatgacct caattccgcc aaaagcgtaa aacgcgtaga ttaaacctgt 316801 ccacagcccc atggcgccgt atgggaaaaa ctcactcgtc ttatttggaa catgtatgcc 316861 atgatttccg ccggacagga taccgcataa agccaggatg gcaatgacaa taaacataaa 316921 aatagcagct gttttaatga ctgccagcac gttttctgtt ttttcaaaga cggacaggcc 316981 ggtgaaaata ataaggagcc caagtactgc gtagattgag gcaaacaccc atagcggcac 317041 ttgaggaaac caatgcttcg taaagagcga aatggctgtc agctggcttc cggtaatcag 317101 catttctgat gtccagtaca cccagccgtt gctgaagcct gcccatttgc cgaatgcttt 317161 tcgggcatac gcacaaaacg agcccttttc cggctgcttc gccgatagct tggcgagctg 317221 ttcaaagaca aaatacgtac cgatccctgc gatcagaaat gaaaggagaa cggaaaaacc 317281 gctttttaca attgcgatgc tggaaccgag aaagaagcct gttccaatcg tgcagccgac 317341 tccgatcagt gacagctgcc accaagccag attccctttt ggctggtctt tttttgtttg 317401 gctcattatt tattcaaccc cttttatcta aggttagatt gtgatctgtc caaagcttat 317461 atacatcgga tttttgcctc tttttacatg gagaaggaag cagacgctca tactaatgaa 317521 aaaaggagca aaccaatgac acagcaatat attgtggagc cgaaaaaagg gcttgggctg 317581 aagctgaaaa aggggcagat tttaaaggtg gttgatgtag aagggcagca ggtggctgat 317641 tttgtcgcat accatgccaa ggatttttat gaacaccttg atcagggagc gacgatagac 317701 gccaatcact ccattcatgt gaaggtcaac gaccatctct actccaacct gtataagccg 317761 atgttaaccc tgattgaaga tacggtcggc aagcatgatc tgctgttgcc cgcctgccgt 317821 cctgatatga acaggctctt atatgggaag caaaaggatg agtttcagga tacgtgctat 317881 gacaatatga accgtgcgct tgagcagttt ggcgtaccga agccccacat gcattaccca 317941 tttgcgattt ttatgaatac tgtccttgat gagaaaggga atctgtctgt ggaaacgccg 318001 ctttcgaatg ccggagatta tgtaaggctc agggcggaga tggatttaat tgtcgcgttt 318061 tcttcctgcc cgattgaaaa agggaaatgc aatggcgaca gtgtgacatc catacgggtt 318121 gaagtcagct gatctctctt gttcacagtg aatgaagacc tgtgctatat ttaataggga 318181 tacataacag tcatgattca ttttcattga tttagggaaa tgatcagtaa taagggaaaa 318241 tgtacaggag gaatgattgg gatgagcatg caggaaaaga ttatgcgtga gttacatgtg 318301 aagccctcaa ttgatccaaa gcaagaaatt gaggaccgag tcaatttttt aaaacaatat 318361 gtaaagaaaa ccggtgctaa aggctttgta ttgggaatca gcgggggcca ggattcaaca 318421 cttgcgggaa gactcgctca gcttgcggtg gagagcattc gcgaggaggg cggagacgct 318481 caatttatcg cggtccgtct tccgcatggc acacagcagg atgaagacga tgcccagctt 318541 gctttgaagt ttattaagcc ggataaatca tggaagtttg atattaaatc gacagtcagc 318601 gctttttctg atcagtatca gcaggaaaca ggcgatcagc tgacggactt taataaagga 318661 aacgtaaaag caagaacaag aatgatcgcg caatacgcga tcggcggcca ggaaggtctt 318721 cttgtgttag gaacagacca tgctgctgaa gcagtgactg gtttctttac gaagtacggt 318781 gacggcggag cagacctcct gccgctgaca ggcttgacga agcgccaggg aagaaccttg 318841 ctgaaagagc tgggtgcacc ggaacgctta tacttaaaag aaccgactgc cgatctgctc 318901 gacgaaaaac cgcagcagtc ggatgaaaca gagcttggca tttcctacga cgagattgac 318961 gattatctcg aaggaaaaga agtatcagcg aaagtatcag aagcgctgga aaaacgctac 319021 agcatgactg aacataaacg ccaggttccg gcgtctatgt ttgatgactg gtggaaataa 319081 gttgaagaaa gcccgctctc ggagcgggct tttgtcgtgt acagaagctt tatttgatgc 319141 ggatatgatt cagctttacc attaatctgt cggcgaacct tcggaggctg cctcttgtat 319201 caggatctaa tgggagttcg gctctcgcgg caatgttctc tgccacatcc tgaatcgaca 319261 ggttgtctgt ttgaatgtgg tcctcaaaaa tgggtgatga taatccttca acacagcggt 319321 caatttgttt ggcggcccat gagttttttc cttctgctct ggtgcgcagc ctttttaaca 319381 aggtttcctt tgaagccatt agtgtaaagt ggtgaacgat cctgccttcc tgtctgagcc 319441 tgccgatgat ctcattgaag tattcagggt gtacaatcgt cataggcaca ataaggatgc 319501 cgcggtatgt atctgtcaga gaagctagca aactgtaatt gaacgcccgc cataaaggat 319561 agctttgaaa atcgtccttt gcgatctcct gcggcaccat ggagcgcagc gcaaaaccca 319621 ttttctcggg atcatacacg taagatgggt tcagccttct gtgcagttcg aaggctgttt 319681 gtgtttttcc cgaaccgaat gccccgttta tccaaatgat catcgccatt tctcccttcc 319741 tatttatcat acagaaaaag acccttccat cgaagagtca gctggaaaaa caataaaggc 319801 ggaaggtttt aacgcttttt tgcgtcgaag tattaaaata cctgcagaaa tgttgtacaa 319861 tgaatgtcat tcaggcaaaa atggctacaa caaagcgcac tataagcttg accggtaaag 319921 ccggtatcta tataaatatt cgctaaataa gcatataatg aatatataat ttcattcctt 319981 aggaggattt cgccgaagat gaacgctaaa cgagccatcc cagtaagaga aagaaatatc 320041 gtcctgatcg gattcatggg tgtaggaaaa acaacaatcg gccaattggt cgctaaaaaa 320101 ttatatagag attttattga tattgaccag cagatcgaaa aggatttcaa tatgtcaatt 320161 cctgagatat ttgagaaaaa gggagaagac tttttccgga aaacggagaa ggaatatatt 320221 ttagacatct gccatcataa acgattcaaa atcgtatctc tgggcggggg atcttttaaa 320281 caagaagaaa tcagaaattg ctgtctggaa aactgtctcg tgcttcatct ggacctgtca 320341 tgggagaact ggaagcagcg cgcggattta ttgatcgaaa gccgccctgt actgcataac 320401 cgttcaatgg atgaaatgga acagctgttt aacgaaagaa aagtcattta tgacaagcac 320461 aattcaaaag tggcaacaga caacctttcc ccggaagagg ttgccgatta cattgttgag 320521 acattaaaaa ttggctggga tctttatcag ccgatgtaaa aagccgtgcg cagcgcacgg 320581 ctttttttat cgttttatcc cttgtatcaa aatcgctttt aaacaaaagg agatgggctg 320641 tccgttttgg ttcaatgtaa tacagaacgt gtcgcgtgct tcgtctgatg cgtgattcaa 320701 gtgggtaatg atttgttttt ctcggtcagc gggggttccg cctcgtttga tccagctatc 320761 gtattgaatc ggcaagttcc acttttggat gtcttgatag gccagttgat tggcgctgaa 320821 catcgcctgc cattctgata atgagctttc acgaacatgg gaagggtctc gaagccggtt 320881 caaatgattg acaaactcat caagaacggg atcttcaggc gcgtaatgat caactaagag 320941 aaaacgtccg tcctgtttta gtacgcgtgc aacctctctg acagctttgc ggacatctga 321001 aaaatggtgg gctgcgtatc ggcaggtgat gatgtcaaat gaatcgtcgg ggaaggggag 321061 tgactctgcc gttccttgct gaaagcgtac gttttcaact cctttttctt gcgcgaagga 321121 ggacgcaacc tcaaccatct ctttcgttgc atcaacaccg atgcactcct gtacataagg 321181 agaaaatgcc agcgccgtat ggccggcgcc cgctcctata tccagcactc gatgctctgc 321241 ccggcattcc gctgttttga tcatcaaccc caaatcttcc ccctcggcaa ataccttttc 321301 atcccgatac atctcggcgt ttttagaaaa cggtgtttca tttgtcattt gaaccagctc 321361 cttcttttcg taaatgatga tatggattat gttagcaatt tctgttatga ttcgtccaag 321421 atataaaaat gatgaaaatg ataggttcaa cctatggagg ctgaaatgga tattaaagtg 321481 atggaatatg cagcggaaat tgcccggcgc caaagcttta caaaggcggc ggaacatctt 321541 catatcgcac agccgtctct cagccagcaa atcaaaaagc ttgaggctga gctggggctt 321601 accctttttc acagatccca tggctctgtt acactgacac ctcacggcag gcgtttcatt 321661 gaaaaagccg aggacatcat tcgttccaga gatgatttgc ttcgggaaat gcaggagcga 321721 tcacagggaa tcggtcataa attatccatc gggattcctg ctgtaacagg gagatatctc 321781 tttcctccgc tgctgaagca gtttttggcg cgctatcctc atgtggaggt tcagcttgtt 321841 gaaaaagatc cggtttcatt agagaagatg acggcaaagg gagaagttga cctttctgtt 321901 ttatccttgc ccatcgagga tgaacggctc tccattacac ccttgctcac ggaaccggtt 321961 gttctcgcgg tgccgaagga aaaacaaagg tggatgccgc cggaattggt cgcgctgatt 322021 gagaaagcgc tggaagaaga tgagggacgc cagccgtgtg tgccgattga catggtaagg 322081 aacgtgccct ttattctgtt aaaagaaggc ttcggctttc gcaggacagt tctcgatctc 322141 tgtgcggaaa gcggctttaa gccgaatgct gcctttaaga cgagccatat tgaaaccgcc 322201 caatctcttg tggctaacgg attaggtgtg acaatggcac cgaatatggt cagaagggat 322261 aaagatccgg gtgtgatcta tttatcgatt caatccgcgc catcacgaac cctcgtcttt 322321 gtctttttaa agaaccgcta tgtcagtctg acggcccagg cctttatgga actaagccgg 322381 gaaagtctta aacaaacgtt tgatgaaggc tgtctgggaa acaaagatga aaatatttag 322441 aaaacaaaga cgaaacgtgg tagtatagga atacaaacta aatcttataa aacaaagggg 322501 aataatcgga aatgcaacta ttcgatctgc cgctcgacca attgcaaaca tataagcctg 322561 aaaaaacagc accgaaagat ttttctgagt tttggaaatt gtctttggag gaacttgcaa 322621 aagtccaagc agaacctgat ttacagccgg ttgactatcc tgctgacgga gtaaaagtgt 322681 accgtctcac atataaaagc ttcggaaacg cccgcattac cggatggtac gcggtgcctg 322741 acaaggaagg cccgcatccg gcgatcgtga aatatcatgg ctacaatgca agctatgatg 322801 gtgagattca tgaaatggta aactgggcac tccatggcta cgccacattc ggcatgcttg 322861 tccgcggcca gcagagcagc gaggatacga gtatttcacc gcacggtcac gctttgggct 322921 ggatgacgaa aggaattctt gataaagata catactatta ccgcggtgtt tatttggacg 322981 ccgtccgcgc gcttgaggtc atcagcagct tcgacgaggt tgacgaaaca aggatcggtg 323041 tgacaggagg aagccaaggc ggaggtttaa ccattgccgc agcagcgctg tcagacattc 323101 caaaagccgc ggttgccgat tatccttatt taagcaactt cgaacgggcc attgatgtgg 323161 cgcttgaaca gccgtacctt gaaatcaatt ccttcttcag aagaaatggc agcccggaaa 323221 cagaagtgca ggcgatgaag acactttcat atttcgatat tatgaatctc gctgaccgag 323281 tgaaggtgcc tgtcctgatg tcaatcggcc tgattgacaa ggtcacgccg ccgtccaccg 323341 tgtttgccgc ctacaatcat ttggaaacaa agaaagagct gaaggtgtac cgctacttcg 323401 gacatgagta tatccctgct tttcaaactg aaaaacttgc tttctttaag cagcatctta 323461 aaggctgata aatgtgaaaa gccgccgcat atcatcaggc ggtttttttc tgcaaactgc 323521 cggaatgaga acagactgga gacgaataga tatgaaacaa agaatcattg atgaattaaa 323581 acggatcgag cagtcatacg gagtcaaaat cgtgtatgcc gtcgagtcag gaagccgcgc 323641 atggggattt ccctcgcagg atagtgatta cgacgtccgc tttatttatg ttccgaaaaa 323701 ggagtggtac ttttcaattg agcaggagcg tgatgtcatt gaggaaccga ttcacgattt 323761 gctggatatc agcggctggg agctgagaaa aacgcttcgg cttttcaaaa agtcaaaccc 323821 tccgctactc gaatggctgt cctcagacat tgtgtattat gaagcattta cgaccgcaga 323881 gcagttaaga aaactccgca cggaggcatt taagcctgaa gcaagcgtgt atcactatat 323941 caatatggcg agaaggaacg tcaaggatta tctacaagga caagaggtca aaattaaaaa 324001 gtacttctac gttcttcggc ctattttggc ctgccaatgg attgaaaagc acggaaccat 324061 accgccaatg gactttactg ttttgatgaa tgaacttgtt gctgaacccg agctgaaggc 324121 tgaaatggaa accttgcttg aacggaaaag aagaggggaa gagcttgacc tcgaagcaag 324181 aatcgatgtt attcaccaat tcattgaaac ggaaatcgaa agaatcatgg aagcggcaaa 324241 agaactgaag gcagagaaaa aagatatgac atctgaattg aaccgtttgc ttttgaatac 324301 ggttgaagaa gtgtggaagg atggaggaag ctgatgtttt ttgtcgcttc cttttctcct 324361 ttattcgaca gaatcccccc ccgactttct aactatctga ttgtggcaaa cccacaaaaa 324421 taatcagaat ctttgtattt tgagaatatt gtgaacgctg gttttgtcca tttacaataa 324481 actcatacaa atacttctta gattgcgggg tgttgaggtt ggaagtgatc acaagagatt 324541 ttttcttatt tttatccaaa agcggctttc tcaataaaat ggcgaggaac tggggaagtc 324601 gggtagcagc gggtaaaatt atcggcggga atgactttaa cagttcaatc ccgaccattc 324661 gacagcttaa cagccaaggc ttgtcagtta ctgtcgatca tttaggcgag tttgtgaaca 324721 gcgccgaggt cgcacgggag cgtacggaag agtgcattca aaccattgcg accatcgcgg 324781 atcaggagct gaactcacac gtttctttaa aaatgacgtc tttaggtttg gatatagata 324841 tggatttggt gtatgaaaat atgacaaaaa tccttcagac ggccgagaaa cataaaatca 324901 tggtcaccat tgacatggag gacgaagtca gatgccagaa aacgcttgat attttcaaag 324961 atttcagaaa gaaatacgag catgtgagca cagtgctgca agcctatctg taccggacgg 325021 aaaaagacat tgacgatttg gattctttaa acccgttcct tcgccttgta aaaggagctt 325081 ataaagaatc agaaaaagta gctttcccgg agaaaagcga tgtcgatgaa aattacaaaa 325141 aaatcatccg aaagcagctc ttaaacggtc actatacagc gattgccaca catgacgaca 325201 aaatgatcga ctttacaaag cagcttgcca aggaacatgg cattgccaat gacaagtttg 325261 aatttcagat gctgtacggc atgcggtcgc aaacccagct cagcctcgta aaagaaggtt 325321 ataacatgag agtctacctg ccatacggcg aggattggta cggctacttt atgagacgcc 325381 ttgcagaacg tccgtcaaac attgcatttg ctttcaaagg aatgacaaag aagtaaaaaa 325441 ggagagatta tcatgacaac accttacaaa cacgagccat tcacaaattt ccaagatcaa 325501 aacaacgtgg aagcgtttaa aaaagcgctt gcgacagtaa gcgaatattt aggaaaagac 325561 tatccgcttg tcattaacgg cgagagagtg gaaacggaag cgaaaatcgt ttcaatcaac 325621 ccagctgata aagaagaagt cgtcggccga gtgtcaaaag cgtctcaaga gcacgctgag 325681 caagcgattc aagcggctgc aaaagcattt gaagagtgga gatacacgtc tcctgaagag 325741 agagcggctg tcctgttccg cgctgctgcc aaagtccgca gaagaaaaca tgaattctca 325801 gctttgcttg tgaaagaagc aggaaagcct tggaacgagg cggatgccga tacggctgaa 325861 gcgattgact tcatggagta ttatgcacgc caaatgatcg aactggcaaa aggcaaaccg 325921 gtcaacagcc gtgaaggcga gaaaaaccaa tatgtataca cgccgactgg agtgacagtc 325981 gttatcccgc cttggaactt cttgtttgcg atcatggcag gcacaacagt ggcgccgatc 326041 gttactggaa acacagtggt tctgaaacct gcgagtgcta cacctgttat tgcagcaaaa 326101 tttgttgagg tgcttgaaga gtccggattg ccaaaaggcg tagtcaactt tgttccggga 326161 agcggagcgg aagtaggcga ctatcttgtt gaccatccga aaacaagcct tatcacattt 326221 acgggatcaa gagaagttgg tacgagaatt ttcgaacgcg cggcgaaggt tcagccgggc 326281 cagcagcatt taaagcgtgt catcgctgaa atgggcggta aagatacggt tgttgttgat 326341 gaggatgcgg acattgaatt agcggctcaa tcgatcttta cttcagcatt cggctttgcg 326401 ggacaaaaat gctctgcagg ttcacgtgca gtagttcatg aaaaagtgta tgatcaagta 326461 ttagagcgtg tcattgaaat tacggaatca aaagtaacag ctaaacctga cagtgcagat 326521 gtttatatgg gacctgtcat tgaccaaggt tcttatgata aaattatgag ctatattgag 326581 atcggaaaac aggaagggcg tttagtaagc ggcggtactg gtgatgattc gaaaggatac 326641 ttcatcaaac cgacgatctt cgctgacctt gatccgaaag caagactcat gcaggaagaa 326701 attttcggac ctgtcgttgc attttgtaaa gtgtcagact ttgatgaagc tttagaagtg 326761 gcaaacaata ctgaatatgg tttgacaggc gcggttatca caaacaaccg caagcacatc 326821 gagcgtgcga aacaggaatt ccatgtcgga aacctatact tcaaccgcaa ctgtacaggt 326881 gctatcgtcg gctaccatcc gtttggcggc ttcaaaatgt cgggaacgga ttcaaaagca 326941 ggcgggccgg attacttggc tctgcatatg caagcaaaaa caatcagtga aatgttctaa 327001 gcgggactaa atgggcatcc tccctgcggg ggtgtccatt tcatccatat actataaaaa 327061 agaggaggaa gtgccataga aaacacacag ctgattattt cgatttgtat ttatatggcg 327121 ggaatgctgc taatcggcta ctttgcttac aagcgtacgt cgaatctgac ggattatatg 327181 ctgggaggac gctctttggg tccggcagta accgctctca gtgccggcgc tgccgatatg 327241 agcggctggc tgctaatggg gcttccgggc gccatgtttt ctactggtct gagcggcgct 327301 tggatcgtca tcggactttg ccttggagcg tgggcgaact ggctttacgt cgcaccacgg 327361 ctgagaacct atactgaaaa agcggggaat tctattacaa ttcccggatt cctggaaaat 327421 cgcttcggag atcaaacaaa gcttctcaga ctgttttcgg gaattgtcat tttagtcttt 327481 ttcacgtttt atgtatcgtc cggaatggtg tccggcggcg tcttattcaa cagcatcttg 327541 gggatggatt atcacaccgg cctgtggatt gtgacgggtg ttgttgtggc atataccctg 327601 tttggcggct ttttggcagt cagctggaca gattttgttc aggggattat tatgtttgcc 327661 gcactcattc ttgtgccgat cgttacgttt ttccacacgg gaggagcagg tgatacagtt 327721 gctgaaatcc gctctgtaga tcctgatatg tttaatattt tcaaaggaac gagcgtcctt 327781 ggcattattt ctttgtttgc ctgggggctg ggatactttg gccagccgca tattattgtg 327841 cgttttatgg cgataacgtc tgtcaaagag atcaaaagag cgcgcagaat tgggatgggc 327901 tggatgattt tgtctgcagt aggcgcagtg ctgaccggtt tgggcggaat cgcttattac 327961 catcagcgcg gcatgacact gaaggaccca gagacgattt ttattcaatt agggaatatc 328021 ttgttccatc cgattatcac gggttttctg atttcagcga ttttggccgc gattatgagt 328081 acaatttctt cccagctgct tgtgacatca agctctctgg tagaagattt gtataagtcg 328141 atgttcagac gctcagcttc agataaagaa ctggtgtttt taggccgact ggctgttctg 328201 gctgtttcaa ttgtcgcgtt ggttctggct tgggagaaaa ataacaccat ccttggattg 328261 gtcagctacg cgtgggcggg cttcggtgca tcattcgggc cagttgtact gctcagtctg 328321 ttttggaaac gaatgaccaa atggggggca ctcgccggca tgattgtggg agcagcgact 328381 gtaatcattt gggcgaatgc cggtctttcg gactttctgt atgaaatgat acctggtttt 328441 gctgcgagtc tattatctgt cttttttgtc agcatattga cgcaggctcc gtcacaagct 328501 gtcacagacc agttcaacga ctaccaagat acaatgtcgc aataaagatc gaaaggagga 328561 ggaaggggct gtcccttttt cctcttttct ccttttaagc ggccattttt ttcttttgga 328621 aacaaacgta tttttttcta tacaaaaaga ccccgtatgg atatgattaa agtaaaaaaa 328681 gtataggaga aaaaggtatg gaagagcttt tagagagagt tttttcattt tcagatgttg 328741 ataagctaat tgattttatt agctatgaac tgcaaaagcc agtgatactg gaaagcgcgg 328801 atttcttttt gttagcctat aattcttact atattaacca ttttgattct gccaaccagc 328861 agactatttt ttcgaaaaag tgtccggtcc agatttttga gaggtttctg aaggacggaa 328921 ttattgaaaa attgaaaaca gagcctgagc cttttcgcgt caataaaatt gaaagcattg 328981 ggttaaacca gagggtggtc gtgagtgcaa agcacaaagg ggaagtcatg ggctacatct 329041 ggattcagga gctggaccaa aatctgacgg atgaagagct cgactttttg tacgagacct 329101 ccttccatgt cgggaaaatc atttataaaa cgaataaatt gaaacaggaa aaggaagaaa 329161 aagcagagga tctcatcaaa cgggcgatct atcagcaatt tacctctgag aaggaactca 329221 gacgggaagc tgaaaggatc aacaccgtgc tgccttccat gttttcagtt gttatcctgc 329281 acgccgcaaa tggggatggg gaagcggttg aggatttaaa ggaaaatatc aggtcgtacc 329341 tgaatttacg ggataaggtc agtcatgtct taacgatcga atcaaacatt gtcatcgtcg 329401 tagcgagttt ttcccaaaaa agctccgtct cctcagcagc ttctgagttt attaacaagc 329461 tgttaacaca ttttcacttt caaaaaatac ctacccctat ttatatcggt atcggaaacg 329521 aatataatca cctattaaaa cttggcaaga gctacacaga agcacttgaa gtcatcaaag 329581 ccgcagaaat caccggcaat caggaaaaca ttccatatga atatgccaaa ctcggcattt 329641 accgctattt agaaagcatc gaacagaaaa atgaattttt agaatacgag aataaagatt 329701 tagctttatt aaaagcaaaa gacgaagaaa gcagcactga gctgctcaaa accttggaaa 329761 tctatctcct caacaactgc aaaacaaaac cagcggcaga acagctgttt attcaccaaa 329821 atacattgaa ttaccgcatc aaacagatta ctgagatgac gtcgatcgat ttaagcgatt 329881 tcagaacgcg gtgccagctc tatctcgatt tgatgctgat gaaaaagaaa taaaaaagaa 329941 accagtactt gtactggttt cgtcttcact taaaatcctc tgtaaacata cggatcatca 330001 ggttttttaa tggtattcca gtcagttact ttgacgacag ggagagttga cttgaatggc 330061 tggtaatatt ctgaggccag agtgccctta atgtgaatcc attcatcatc cttgatgtcc 330121 atgtccttcg gaaattccac aagcatcccg tacacgccgg aatcagcgat acagtgaatg 330181 atgccaaacc ttaatacgaa cagctgattt ttgttaattg cgtttccttt gtaagcaaat 330241 ccatgaaatt ctatcgtccg tccgagaaat tcacccggat agttatagat ggtttccatt 330301 ccttttagga aatcgtcatc ggtcagagaa atctcttttt tgctggaata cttattaaac 330361 agctgtttca tttgtttgtc atagctgtct tgcgcgtaat aaaggctggc atcaggccgc 330421 aaatactgtg tttgggagta gtgatctccg ctctccatcg ccttaaacga gaaccctttt 330481 gttttgacta tggatgagtc aagcgttgca atcgggaaga agatgcctga caccaaagga 330541 aaaagaaaaa caacataaat caaataacgc tgataaaatg gcttgttttg ttcatggtca 330601 tgctcgtgat catggccgca cccgcaatca tggtcatggt gatgtccgct tttttcaggc 330661 gacttgataa atagatatgc ttggacggcg gtcagaatgg ccagcaggaa gatcgcaata 330721 aaggaaagat aggcatattt catattgata tattttgtta gatttcctga ggcatgcaga 330781 tgataaaaga aaaacgtaaa tcccatcagc accaataaac gaaacatcca atcacccctt 330841 taccagtagt gatcccgcta aaacaatcac gacaatgtat gtaatcagca ggaaaacaaa 330901 tcgttttttg aaggccgcaa gcatcatcaa tagattctta atatccacca ttgcaccaaa 330961 gacgagaaag gcgattaacg atcctaatga aaacgtgctg ctgaaggaag acgcgatgaa 331021 cgcatcaact tctgaacaaa gcgacaggac aaacgccaga cccatcatca cgagggaaga 331081 ggatacatca ttctgcccga tcgcaagcag agtggatgtt ttgacatacg tctgcatagc 331141 ggctgcgata aaggcgccga tgattaaata tttccccacg gagaaaaatt catcaatggc 331201 atgccgcaag gtcccgccca gtttttggag caaggtgccg tgatgatgat ggtggtgccc 331261 gggttcatca ggctttaaaa gctggttatc cttaaattga taggataaga tgaccccgat 331321 gatcagcgaa acggcgagag ccagtccgcc tctgtaaaag accacgctcc atctattccc 331381 gaacgcaata taagtagaaa ataaaacgat aggattaatg ataggcgcgg tcagcatgaa 331441 agcaacgccc gcatgcagag gaactccctt taacagaagc cgcctcgtaa tcgggatgat 331501 gccgcattcg caggcgggaa ataaaacgcc ggccagcgca ccgaataaaa cggcgagaaa 331561 acggtttttc ggcatgattc ttgcaatcat ttcttcagaa acaaacattt gaatgattcc 331621 ggaaagtatg acgccaatca gaataaacgg aatggcttct attaaaatgc tgataaaaat 331681 agaattcagc tgaagaaaag atgattgtgc tgtcacaata aaacctccgc tcatgttaag 331741 ctgcctttct tatgatacca gaaaaaaagg cactgcttgt ttgacggagg aggggaaagg 331801 atcgtttcac tttggttagg attccaaaaa gccgagtagg atactgcctg tttctgcagc 331861 ttcttttccg agccaaatca ggtgtcccca tgagtgaagc aaacagagaa cagcgccacg 331921 aatgtgctct tttgcatgat gtgcatgtga caagtcaacc aatccgtcat aaacactttg 331981 cataatcagc acgggacata tgatggcttg caggtctttt aaagagacag cggcggtttg 332041 tgacaagtca atcagaaatc cttcacccga gcgctgccgg ctgttcattt tccgaaatgc 332101 ttctatgtct ttttcattca tcaaggactt gattcgctga aacggaagcg tgctgaattg 332161 ggggctcata gctcgaaaca tcaaacgcgg gaaagcgtta ttcaaggaag aaatcagctt 332221 ccatatccac ttttccaccg gcgggcggaa gagaatttcc cccaatttat attcagtgtc 332281 ttttggggtg agccactctt tggtgactgc ggattgcagg gtcaatgtat ttactctttc 332341 cggataatgt gaggcaaagc atatgccgct cggccctcct gctgagatgg cgatcacatg 332401 gacactctcg atttgtagat gatctaataa tttcacatag aaacggcagg cattggcaag 332461 actttttcca atttcttttg acgtccgtcc atagccaggc cttgaaggcg taatgatgga 332521 atacccttgt tcaatcaacg ctgtgtatcc gaattcctcg taacaatttg aatgcccgcc 332581 atgcatgaca aggatcggag ttcccttgcc tgtcacagaa tattctagtg taccgccatc 332641 gaaggtgatc gtttcaactc gtcttttcat ctgtttcacc caattggttt ttgcctatta 332701 tagagttttc agcaattgac cacaaggtag aagaaatgaa taaacaaagg cccttgaaat 332761 atgatatact ttgtattgat attcattctc aattaaaact ttgatataga tgtgaacggg 332821 aggcaggacg gatggctgag aatcaagagg tatatgacgt tacgattata ggcggggggc 332881 cgatcgggct gtttactgct ttttactgcg ggatgcggga gctgaaaaca aaggtaatcg 332941 aatttttgcc gaagctcgga gggaaggtgt ctttattctt tcctgagaaa atcattcgcg 333001 atatcggcgg cataccgggg attgcgggaa agcagctgat cgagcagctg aaggagcagg 333061 cggcaacgtt tgatcctgat atcgtattga atcagcgtgt gaccgggttt gaacgcctag 333121 atgacggcac cattgttctg acgggttctg aagggaaaaa gcactataca agaactgtga 333181 ttttggcttg cggcatgggt acacttgagg tcaatgagtt tgacagcgag gatgcggccc 333241 gatatgcggg caaaaatctt cattatggag tggagaagct cgatgcgttt aaagggaaac 333301 gcgtggtgat atcaggcggc ggagatactg cggtcgattg ggctaatgag cttgaaccga 333361 ttgcggcgtc tgtgactgtc gttcatcggc gtgaggaatt cggcggaatg gaaagcagcg 333421 tgacgaaaat gaagcaatca tcggtgcggg tgcttacgcc ttatcggctg gagcagttga 333481 acggagatga agagggcatc aaaagcgtga ccgtttgtca tactgagtct ggccagagga 333541 aagacataga aattgatgag ctgatcatta atcatgggtt caaaattgat ctcgggccga 333601 tgatggagtg ggggctggag attgaagaag gaagggtgaa agctgacaga catatgcgaa 333661 cgaatcttcc gggcgtgttt gtggcgggcg acgcggcttt ttatgaaagc aagctgagat 333721 tgattgccgg cggatttacg gaaggcccga cagcggtcaa cagtgccaag gcttatctgg 333781 accctaaggc cgagaatatg gcgatgtatt ccacccatca taaaaaattg gtgcataaat 333841 aaaacagccc ttgaggaaaa gggctgcttg ccatcaggtg tgaaggagtt ttttctctgc 333901 atgttgattg tggatgaaag ctagcaattc atcctgttct tgtacggctg tgaatccata 333961 aatgccggca gctgagtcat cgcctatgca gacgatagga gggcggcttg ctgacggttc 334021 cggcaaaatg ccaatttgtt cgccaccatt gatcaattgc tgaacggaca gcttgtttgg 334081 gcaaatgacc atgtgcagcg gggattcact gatggtacgc tgaatcatgt gggtgaaccg 334141 gtcatctatg acgttttcat gagtgatata aaacgaacag gattcatgct tttgcatgtt 334201 ttccactgca tggcggctcc cgacaacaag acgtttctct gaatcaggct gaatggcggt 334261 gacaagaaag ccccgtttct caagctctgt ctttgcttgc tcagatgctg cactcagttt 334321 ggctgtcagc tggcggatgt cgattttctg agaagccagt gctctgaaaa attcacaaac 334381 cgcccggcgc gatgtgaaaa aaacgtcttc aaaggtgcca atctttcgaa gaatttcttc 334441 attgacaggc atgttttcgg tccgccattt cggccactcg atgagatcgg cgccggaatc 334501 gcgcagcttg tctgcaagcg ggtcttcatc ttcgccatga gtcacaacca tcaaatgccg 334561 tccgatgagc ggtttgcttt caaaccagct gtgtgtttga aagttgacga tgtctccgat 334621 gacgataatc gcagggtttg taatctggtg ttcctgcact ttttgctgaa tgttctcaag 334681 tgttcctttc acactccgct ggcggcccca cgttccccat tggatgacaa tgacagggac 334741 agaaggcgat ttcccgtatg aaataagctg ctggcaaata taagacaagt tcttgacacc 334801 catgtaaaaa acaagggttt gaacgcttcg ggccagccct tcccagtcaa ggttcggcgt 334861 gccttttaat gatttatcat gcgctgtaat catggcaaaa gacgatgcaa aatcccgatg 334921 cgtgacgggg atgcccgcat atagcggcgc tgcaattcca gaggtgattc ccggcaccat 334981 ttcatagcga atgccgtgct catgaagagc atctgcttcc tcgccgactc tgccgaatac 335041 gctcggatct ccgcccttca agcgaacgac ggttaaccca tttaatgctt tttcaaccag 335101 cagggcgtta atttcttttt gtttcataaa atggcggttt ggcagttttc cgcaataaat 335161 aaactggcag tccggtgatg caaattcgag cagcttcggg ttggcgagcc ggtcatataa 335221 aatcacatct gcttccttga gcgcctgttt tcctttgatg gtgagcaggc ctgggtcgcc 335281 gggtccggct cccacgaaat atacgattcc gttcttcatg atcatgtcat ccttccgtca 335341 ctgtaaaaaa tgaaggacca ctagaaaagt gatccggtct tttgatcaat atacgagata 335401 aacatgttct ccttcgatca gcgtttcata tgttttgacg catccgtggt caggttcttg 335461 gacgattccg tcttctaagg aaattttcca gtcgtgcatc gggcagaaaa catattgacc 335521 gctgacgatg ccttctgcca ggacgccgcc cttatgcgga cagcggtttt caatggcgcg 335581 gatgcttccg tctgaaagct tgaaaaccgc gagctcctta tcttcaatat acactgtttt 335641 gcctaattgt tcaggcaatt cttcaatttt tccgatacat acttttgtta cgtctttgtt 335701 taccatgtcc attcctcctc aatgatagtt tttgtcatta tgatgtggtc acgacatttt 335761 caaataattc tttagaggtt tgtttatcct ctaaaaagtc tttccacgga tccttgtgga 335821 cagagagtgt ttcattcatt cggccgttca gctcctgccg cttttccgga tcgtttaaca 335881 cggattggac atgggataaa ccgacgcgct caagccatgc ggacgtacgc tccagatagt 335941 ttgcggtttc cctgtaatat tgcaggtaag cgcccgcgta ttctaagact tcttcatttg 336001 ttttcacctt catcagcaaa tcgccggcac gcaaatgggt tccgccgttt ccgccgacat 336061 aaagctccca gcctccgtcg atgccgacaa cgccaaggtc cttaatgccg gattccgcac 336121 agtttcgcgg gcaggcagac acggccattt tgactttgtg aggcgtgttc agcccttcga 336181 attttttctc aagcgcaatg cccagtgcca tggagtcttg tgtgccgaag cggcagaatt 336241 gctcgcctac acatgttttc actgtgcgga gcgtttttcc gtacgcgtag cccgatggca 336301 tatcaagatc ttcccatacc ttcggaaggt cttctttttt cacgccgata agatcaattc 336361 gctggccgcc tgtcattttc acgagcggga tctcatattt gtcaacgaca tcggcgatct 336421 tgcgcaaatc tgtggagttg gtcacgccgc cgtacatccg aggaacgact gagtatgttc 336481 cgtctttttg aatattggcg tgcattcgtt cattaacaaa gcgggatgtc cggtcatcct 336541 cgtatttggt tggattgatc atgcctaagt agtagttcag agcgggtcgg catttagaac 336601 agccttctgg cgttttccag ccgagcacat tcatgacttc tcttgtatgt gacagccctt 336661 tggctttgat ttcttctacg acttcatctc tcgacaatgt ggtgcagccg caaatggctt 336721 ctttttgcgc tgacgcatca aagtctgatc cgagcgtatg ctggaggatt tcttctacga 336781 gcggcttaca gcctccgcat gagcgggatg cgccggtgca tgctttgatt tcgtccgttg 336841 acgagcagcc cttttcctgt atggcttgaa taatcgcacc ttttgacacg ccgttacagc 336901 cgcagatgat ttcatcgtcg ctcatcgctg cggttatgct tgtgcctgct tcctggctga 336961 ggggctgtaa gattgatatt ttagaggttt cagagatatc ggcttctttt tgaatcatag 337021 aaaacaggcg attgccttcg ctgctgtcgc cgaataaaac agcaccgaca atttgattgc 337081 ctctcaggac aattttttta tagatgccgt cctgctcatc gaagacttta atcgcttttt 337141 tctcctctga ttcgttaaag tcaccggcag agaagacctc gacgcctgat acctttaact 337201 gtgtggagag aacggagccc tcatacggtt ttgtttcgat gccgcacata tgctttgcca 337261 gcacttttgc ctgttcatac agcggcgcca caagcccgta ggcgattcct cggtgctcgg 337321 cacattcgcc gaccgcgtaa atgtgcggga tttcagtctg catataatcg ttgacgatga 337381 tgccgcggtt aaccggaatg ccgctctcgg ccccgagcgt tgtatttggg cggatgccga 337441 cagccatgac gactaaatca gcttcaatgc ttgtgccatc cttgaatcgg aggccttcga 337501 cacggtcgtc accgacaatt tcttctgttt gcttttcaag taaaaaggtc ataccttgtt 337561 tttctaactc gttttgcagc aggcgtcctg ccgttgcatc aagctggcgc tccatcagga 337621 atggggcaag gtggatgacg gacacgtcca tgccgagatt cagcagtccg cgagctgctt 337681 ccaaaccaag tagtcctccg ccgatgacgg cagctttttt atattgtttt gacgcggcga 337741 gcattgtgtc tgtatctttt atgtcccgga aagctgtgac gccttttttg tctgcgcccg 337801 gaatcggaag gataaaaggg accgatcctg tcgccaggat caattcatcg taaggctgga 337861 ttctgtctgc atctgtgatg actgttttgt tttccgtgtc cactttgatg actgtttcat 337921 ttgtatacaa ttgaatgttg ttttcttcgt accagtccca atcgtttaac gtaatatctt 337981 taatatctgt atcgccttga agcacttttg acaaaaggat tcggttgtaa ttgggatgcg 338041 gttcggcacc gaaaattgtg atctgaaact cgtctttagc aacactcagt atctcttcaa 338101 tggcccttac cccggccatt ccattaccaa caagaactag ctgttttttt cccatcagat 338161 gatccgctcc ttatcaaatg ttttttccag cgtagcacag caaaaaggaa tatttaagat 338221 acatgttata aaatgtaaca aaatatacga aaagttctaa aaattttatg aaaaatttaa 338281 ataggtatga ttcggacggc gcatacctta aaaccgggca ttttacaggc tggatctaag 338341 gcttccccga ttaaatcatt cacattttga gcgtctgccc aatggatggg aacaaaaacg 338401 gtatcttttc tgatttgttc tgataatttg ctgcggacgg tgatgcttcc ccgcggcgat 338461 tctattttta ccagtacacg gtcctcgata ttgtaggtcg ctgctgtttg cggatggatc 338521 tccataaacg attcaaaatg tctcgcggca agggcggcgc tttttcttgt ttggacgcct 338581 gttaagtagt gagacatgac tctgcctgtc gttaaataaa gcggataatc ggctgtcggc 338641 ttctcttttg gaacaggtgg ttcgtttgga atcacactta atgccgcttt ttgatccgga 338701 tgagcaaatg attctgtaaa caagcgccca gttccgggat gatcagattc cggacacggc 338761 caatgaatgc cgccttcacg tctgagcctg ccgtatgaga tgcctgaata atcggcaatc 338821 ccgcctcggc tcgcttctct caattcattg aaaatatcct ccgctgacgt ataagaaaag 338881 tagcggccct tgccgagagc ggatgcgaga tcacaaatga tctgccaatc atgctttgct 338941 tcgccggggc atggccggct tgcttctctt aatgtcacgc gtccttctac atttgtcatg 339001 gtgccttcat cttctaagta agaggaggca ggtaaaatca catctgcgta tttcgcagtc 339061 tcagaaataa acaaatcgat tgcgacaaag aatgtcagtc ttcttaaagc ctttttcacg 339121 agatttgcat ttggactgga aacagcaggg ttggagcaca tgaggaacag tcctttgatg 339181 tcgccgtcat tgattttttc catcatttca taggctgaga caccttttcg cgggagttca 339241 tcctgatgga ttccccacac tttcgcaata tgcgcccggt gttcttcgtt ttcgatagaa 339301 cggtagcctg gaagctgatc ggctttttgg ccatgctctc tggcgccttg cccgttgcct 339361 tgtccggtga tcgccccgta gcccgagtaa ggtttgccga tttttcctgt gatcagcacc 339421 atgtttaaga agcctttcac agccgctgtt ccatcggttt gctgttcaat cccgcgggct 339481 gtaaacagca tgccggacgt ttccttggca aacttcacag cagcttttct tatatccacc 339541 agcgagacac tcgtctgttc ggcgatgtca ttcaggtcca acgagtcagt atgctgcttc 339601 agctcttcga atccatttgt tcgtgattga atgaaatcct cgtttataag ctgttcgtca 339661 atgatgattt tgacgagacc gttggcaagg gcggcgtctg tgccgggttt gattttcaga 339721 tgaagatcgg cgattttcgt tgtcgctgtt tcacgaggat caatggcaat gaagtaagct 339781 ccgttttctt tcgctttttc aaaatacggc ataatcgtag gctggcattc cgcaatattg 339841 gtgccggcca gaatgatcac acgggtgtgg gggatgtctg ataaaggatt cgttaagcct 339901 ctgtccgcgc cgaatgtttg gttggctgcg gtggctgctg cggacataca aagtctcccg 339961 ttgtagtcga tgtattttgt ctgtaagcct actcgtgcga acttccctaa caaatacgcc 340021 tcttcatttg taatcgaggc gcttccgtat accgccatgg cgtcatgtcc gtgttcagtt 340081 tggatcattg tcacttggtc tttgatatga ttcagtgctt cttcccagga aacaggcata 340141 aactcgccgt ttttcttcag cagcggccgg gtgatgcggg aggagttcaa ggcatgctgg 340201 tgagcattca tgcccttgat gcatagccga ccctgtgtcg taggattatc aatcccgatc 340261 gcagtgtact ttttgcgcgt gacgatggtt tgttccacga gctgcatttt gcactgcatg 340321 ctgcaaaacg ggcattgagt gtcatatgtt ttttctgatt ggacgtcttg ctgtttatca 340381 cggaaatatc taagcagtcg ttcagtcaaa atgcctcatc ctttcttata tgcgcccgtc 340441 tctacagtcg ggttttgaat cagtgacaga tctgtttgga ggctttccag cagctgtgcc 340501 cttaggtctt cttcgaatag cacttctctg atatgaacga tcccgagacg gtctatccac 340561 tgatgaacac cttctaagta atgagccgtt tcccgataat actggatcag tcctttgatc 340621 atgccggcag tgctgtcttc gttctcagtc acgcaaaaca aagctcctga acgggcatga 340681 gttccccgga cgccgccgat gtgaatgtcc cagccagctt gtgtccgaat tgcgccgaca 340741 tcttgcaggg cggcctcggt gcagtctgtt tcacatgata agctgataga aatgggagcg 340801 ggtaagggaa gcatctcaag ttgtctttcg atttgggctg ccagctgctg aatcgatcga 340861 ttttgcccgc atgtacatgc tttgatgctt tgcagcgcgt gtcggtgttc attagtgtaa 340921 acgggcattt tcaggtcttt tttcatgttc gggagatccg caggcttgat cccggaaagc 340981 ttcagccttt ggccgtgagt gatggatacg tcgggaatgc tgtatgcctc aatgatgttg 341041 gcgatggttc ttagctgctc cgcgtttgtc cgcccgccgt acatttgcgg aatcaggatg 341101 catgtctctt cagtggctgg ctcaggctgg acaaacccag ggtacagcat ttccagatag 341161 tattgaatcg caggaacaca agtactgcat ccgttttttg ttttccagtc aagctggttc 341221 atcacttctg ccggattagt gaatggcctg cgctgaagct cagcgatgat gtcgtcttct 341281 gtaaaatcag tacagctgca aaacgaaggt gtgctggcgg gcttcgtata ttcgctgttg 341341 gtcatgtatc tcaaaaggtc ttcaacgagc ggtttgcatc ctccgcagga cccagtggct 341401 ttggtgcagt gcttgacttc ctcaacagtt gttaagctat tcgtgtgcac cgcgtcttca 341461 atcgcgcctt tcgtcactgt gttgcattgg caaatcgttt cactggaagg catggattca 341521 aataaagggc cgcttgtctc cggttcgatg atctgttttt tggcaatgga gatgtctcgt 341581 tgtttaagca ggctgtcgag aagccgctgc ttgtcacggg tgtctccgaa taaaataacg 341641 ccggccagtt tgtcatctac aaaaagcgct tttttataaa cgcctgcttg ttcgtcgtag 341701 attttgatgc tcgtcgtgcg ttcatcctct tggatctttc ctgctgacca cacatcgatt 341761 ccagctattt ttaacgccgc agatggtgct gagccttgat attcctcaca tggaacgccg 341821 caaatatgac tggcgagcgc ttttccctgc tcataaagcg gagccaccaa tccgtacacc 341881 gttccgttat gctcagcgca ttcaccaacg gcgtagatat tcggttcgct tgtctgcatg 341941 aagtcattca cgatgatccc gcggttcact ttgattccag cggatacagc caattcaata 342001 ttcggtttga cgccggccgc catcacaatc aagtctgctt ttaatgaaga gccatcttta 342061 aaatggattc ggtctgcctt cgtggcgccg gaaatggaga cggtgtcttt ctccaaaaga 342121 aaggttaggc ctttttgttc cagctctgtt tgcagcagcc gcgccgctgt ttgatcgagc 342181 tgtttttgca taatgccggc ggagtggtga atgacgctga catccatacc gagatgctgt 342241 aaacctactg cagcttccag tcctaataag ccggctccga ttaccgcagc cttttgaaag 342301 tgctgggcca tgttcatcag cgcttggcag tcttctattg tccgaaatcc atagacacct 342361 tttttgtctg ccccggggat agggagaata tgaggggagg agcctgttgc cactattaat 342421 ttgtcatacg acagagtgcg tttccgatct gtgatgacct gctgctgatc tgtatcaatc 342481 tgaataaccg tttcgcctgt gtaaagcgtg atcccgtgct tgtcgtacca atccttgctg 342541 ttcagtgtaa tatcatcgag tgacgcttca ccctgcaata cagaggataa gagaatgcga 342601 ttgtaattgg gatgcggctc gcttccgaaa atgacaatct caaacatgtg gcgattcagc 342661 tttaatactt cttcaataca gcggattccg gccatgccgt ttcccgctaa cactaatctt 342721 tgtttcttca tgtatcagac ctcctttggc gaagctcgta agttttctcc tattaaaaat 342781 tatgtcacaa tgcattgtta acgcattaaa cgtgtcacaa aaacttacac atgtcttttc 342841 cagaaaataa tggtcctata tccttgattc agaaaatgta aaataatgag ggtctagaaa 342901 ggggaatctt atgaagctgt cggaactgaa aactagcggt catccactca ctttgctctg 342961 ttccttttta tactttgatg tcagttttat gatatgggtt atgcttgggg cgctgggtgt 343021 ttatatttct caggattttg gcctgtctcc ttttgagaaa gggcttgtcg tagctgtgcc 343081 gattttatct ggatctgtgt ttcgtatcat tcttggtatt ttaacggaca gaatcggacc 343141 gaaaaaaacg gcagtgatcg ggatgctggt gacgatgatt ccgctgcttt gggggacatt 343201 cggcggccgt tccctgactg agctgtatgc catcgggatt ctgcttggcg tggcgggagc 343261 aagctttgct gtagcgctgc ctatggccag ccgctggtat ccgcctcatt tgcagggact 343321 tgcgatgggg attgccggag cggggaacag cggcacgttg tttgcaaccc tgtttggccc 343381 tcgtctggca gagcagttcg gctggcacat tgtcatggga attgcgctaa ttccattatt 343441 gatcgtcttt attctttttg tatccatggc aaaggattcc cctgcacagc cgtctcccca 343501 gccgctcaaa agctatctgc atgtgtttgg gcaaaaggaa acatggtttt tctgcctgct 343561 gtacagcgtc acatttggcg gatttgtcgg gctctcaagc tttttatcta ttttctttgt 343621 tgatcaatac cagctgtcaa aaattcacgc aggggacttc gttacattat gtgtggcggc 343681 ggggagcttt ttccggcctg tcgggggctt gatttcagat cgtgtcggcg gcacgaaagt 343741 tctttctgta ttgtttgtca tcgtggcact gtgtatggcc ggagtcagta gcctgccatc 343801 tctctcaatg gttattgttc tattgtttgt cggaatgatg gggctcggaa tgggaaacgg 343861 cgcagtattc cagctcgtgc cgcagcgctt ccgcaaagaa atcggcatgg tgacgggaat 343921 cgtcggtgcg gccggaggaa tcggagggtt tttcttgccg aacatcttag gatctctcaa 343981 acagatgaca ggcacatatg ctatcggttt tatcacgttt tcctgtatcg cgctgctggc 344041 gtttgcactt gtgcttgccg caggctatta ctggcggaaa agctggagcg cggaaagcag 344101 cccggcggat gtttaggatt ttgacggaca cgcgtttgtg cgtgtctttt ttattttctc 344161 ttgattttca acagtgaacc gatcaaaata aatagtaatt attacgattt gttagtgaga 344221 ggagttttct gaatgaatca acatacgctg ctcccgaaaa aaacggagcg tcttcaatac 344281 tttggatcgg tcagtccgat caaaggcgag aaaccagtgg aaaaagagaa aatgaaggac 344341 ctgcaaaata tcaggaagga ttattttttt gacattcagc atgtaggtgt agctaatgtg 344401 tcccatccag tcacaatcac ttctgccatg atgcctgccg agcaaacaac ggctgcgaac 344461 tttacaatga cttgtaattt gccgagaaat cagaagggga ttaacatgag ccggttaaca 344521 gagctgctgc aagtctatca tcaaaatggc tggattctct cattttcctc tcttcagcaa 344581 tttacgaaag agcttgcaga aaacatggac acatcatctg ccacagttga agtgaggttt 344641 ccgtggtttt tcgaacggaa aagcccgaag cttgagaaag cgggtttgat gcatgctgat 344701 atattcatgt ctgtcaccta tcgcaaagat cagccgttta aacagcgtgc cggcatctca 344761 gcaaaagtaa cgactctgtg cccttgctcc aaggaaatca gcgaatacag tgcccataat 344821 cagaggggaa cggtcagcat ttgggcggat attcacccgg ccgcatcgct gccaagtgat 344881 gttaaagctg atttgcttca cgccgcagaa tcaaatgctt ctgcgagact gcatccggta 344941 ttgaagcggc ctgatgaaaa agccgtgaca gaaacggcct atgaaaaccc gagatttgtt 345001 gaggatctcg cccggctgat tgctgcagat ttgtttgagc ttgaatgggt gtcagccttt 345061 gagattgaat gccgaaatga agaatcgatc catcttcacg atgcctatgc gaagctgtgt 345121 ttttcgaagg aagtggataa aatatgaaac tctcattatt cattattgca gttcttatgc 345181 cagtcatcct gctgtcagcc tgctccgatc atgcagaaga acacgcaagt atcaatacaa 345241 agaaaacggt cgaaaacata acggacgttc gaaaaacagc aaaaacaagc attgattgga 345301 caaagccttc gggcggagaa tacccggata ttaaacagaa gcatgtctgg attgatgtga 345361 atgtgaagga gcagaaggct tacatcaagg aaggaagcaa caccatctat acaatgatga 345421 tttcttctgg tcttgatcaa acaaaagatg atgctacgcc aaagggcacc ttttatgtag 345481 agcctgaacg gggagaatgg tttttctccg aaggatacca ggaaggcgca gaatactggg 345541 tatcatggaa aaatcacggt gaatttttat ttcatagtgt gccaatgact aaggatcaaa 345601 aagtcatcaa aacggaagca gaaaaactag gaacgaaagc atctcacgga tgtatcaggc 345661 tgaccattcc agatgcgaaa tgggtatatg aaaatatccc tgaacataca aaagtggtga 345721 tcagctgaat tgaaaaccgt tgacaaaaag gaaaaaagac catacaattt aaatcgtaac 345781 aattacgttt tatgataaat ggcttatcat tgtctgtgca tctgtgaaaa gcggaaaggc 345841 atcgattaag gatcttgctg tcggcaaagg caaggatttg cgatggggaa aaggattaaa 345901 cgcggttgga gtctttactg atttagaaat cgggcggcag cgagaaatga gcgcgaaaag 345961 ctgctctaca ccattgtaca tacggcgaag tattcaattt aaatcgtaat cattctattt 346021 taatggaggc actattatga aaaaaattcc ggttaccgta ctgagcggtt atctcggtgc 346081 gggaaaaaca acattgctga acagcatttt gcaaaatcgc gaaggcttga aaatagcggt 346141 tatcgtaaac gatatgagcg aggtgaacat tgacgcgggc ttggttaagc aggaaggtgg 346201 cctttccaga acagatgaaa agcttgtgga aatgtcaaat ggctgcattt gctgcacgct 346261 tcgcgaagac ttattaattg aagttgagaa gctggcaaaa gacggacggt ttgattatat 346321 cgtcatcgaa tcgacaggaa tcagcgaacc gatcccggtg gcccagactt tctcttatat 346381 cgatgaagag atgggaatcg atcttacaaa attctgtcag ctggatacga tggtgacggt 346441 tgttgatgcc aaccgttttt ggcatgatta tcagtcaggc gaaagccttc tggaccgcaa 346501 agaagcattg ggggaaaagg atgaaagaga aatcgccgac ctcttgatcg atcaaattga 346561 gttttgcgat gtactgatct taaataaatg tgatttggtc agcgagcaag agctcgaaca 346621 gcttgaaaac gttcttcgta aactgcagcc aagagccagg ttcattcgtt ccgtcaaagg 346681 aaatgtaaaa ccgcaggaga ttttgcatac agggttattt aacttcgagg aagcgagcgg 346741 atcggccggc tggattcaag agctgacggc aggccatgcg gaacacaccc cggaaacaga 346801 agaatacggt atctcttcat ttgtatataa gagacgtttg ccgtttcatt ctacacgatt 346861 ttaccgttgg ttggatcaaa tgccaaagaa cgtggtacgt gccaaaggaa tcgtctggtg 346921 cgcatctcat aacaacctcg ctttgctgat gtcgcaagca ggtccgtcgg ttacgattga 346981 gcctgtatct tattgggtgg cggcgttgcc gaagcttgag caggagcaag tcaaacagca 347041 ggagccggaa atcctggagg agtgggaccc ggagttcggc gaccgcctaa cgcagctagt 347101 ttttatcgga actgacctgg atgaagaaac gatcacgaaa gagcttgatc aatgcctgtt 347161 gactgagtat gaatttgatt ccgactggtc gctgtttgag gacccgttta aatggaagct 347221 gaatcaatag aaaaaaagcc gtcccatggg gaacggcttt ttttaatgaa acgtttgttt 347281 aaacataatg agcgtatttt ttctcaagga tattctgaaa gaccgcggca atggagcaga 347341 tggcccaata aatgagagcg gtcagaatat acatggtcat ataatcaaac tctctgcccc 347401 cgatgatttt cgcatgctgg agcaattccg gcactgtaat catcgcagcg agagaggacg 347461 ccttgatcaa gtcgagcaat acattggcaa gcggaggcag cgcaatacgt atcgattgcg 347521 gcaaaatgat gcccctcatc gtctgccaat aggaaagacc cagcgaggat gcggcttccc 347581 actgtccttt ttcgacggat gaaatggctg aacggttaat ttccgcaatg taggcggcgc 347641 tgtttaggct aaagccgatt aaagcagccg tgacagcgga aaattcaatg ccgatataag 347701 gaaacccgaa ataaaggata aacaaaatca ccaaaatcgg aacgcctcgc ataaatgaga 347761 tatagagctt cgccggccat cttaacaaag caagtttaga cattctggcg agtgatatga 347821 acaggccgat cacagttccc gcaaacatgc ttacaaaaga gatgagcagt gtataaccaa 347881 tgccttttat gacataaggg aacgattcaa tggccagctt cgtgttgaaa atatattccc 347941 actgaatgct attgatcatg gcgtccgatt acaaatcaac gtcctgaacg tcggcatcaa 348001 ttttttttga tacatctgct ttattgaaga attgtttcga cagtttagtc aaagagccat 348061 ccttgctcat ctctttcaat gcttcgttca tctttttctg aagtgccgca ttgctttttt 348121 tcatgacaag ggcctgtttg ttcggcatgt acttgatgtc aggatgaatt gtaatgttga 348181 gatccgggaa tgccgcgagc gcaagtgtct gcaggtaata gtcgtttaaa atgacgtcag 348241 tgcgtccgtt ggcaacatct tttaaatatt gctcattcgt cgcattatca taaatcactt 348301 ctttggcgcc gtattttctc gcgacctcca tgtagacggt tgtagccgcg ccagccgctt 348361 tcttcccttt taaatccttg agcgttttaa tccctgataa atcgtctttt cggacaattg 348421 ccgtgccgta tgaatattta tatggagtgg aaaatgcgaa cttctcctca cggtccttcg 348481 tcacatcgat gtcattcgcg gctgcgtcaa cctgtccgct gttcaccgct gtcagcatcc 348541 cgtcaatgcc catctccttg aactcaacct tcagccccaa gcgttttgcc gcttcacgaa 348601 caacttcaac ctcgtagccc gtcagcttat cagagccaga gtcagtatcg tgataagaag 348661 tgggatagag cgtacctgat gtagcgacta cgattttccc tttatcctta atctgctccc 348721 agcctgtatc cttggaatcg gcttcatttt tgccggaaca ggctgccaat ataagaaaga 348781 aagccattgt gaaactgaat ataacggctt tggaatgcat gaatgatttc acctatagtt 348841 cccccaatct gttaatcaac taaaaagata gcattgaaca taaggggttg caatatgttg 348901 atcgcgtttt caaaaagttc gaattgtgta tacaaaaagc atgggtgggt gtttaaaagc 348961 gtctatgaag ggaagaggtg atgaaaaaag gaattgtcca aggatgaatg ccagacgtac 349021 caaggaaacg catgtgaaag tgaaggatgc agcagacccg tcactcatct atgccaatac 349081 cggaagaaat ggtcaagagg catgaaaccg atcttcagaa taaatttaag tcttgctgat 349141 gcccctaagg catatgatat attcgatgag aaagaaaatg gaaacattta aaccataatg 349201 gggagtcaaa tgaatattta caaaccagcc ggattttgga tcagacttgg agctgcattg 349261 ttagactaca ttatagtctc cgtgccgctt ttgctgatct attggctgat tacaggaaaa 349321 gacccaaacg acagcatgtt catcagtttg gttgttctgc tgtattctat tttgctgccg 349381 atgttttggc gcggttatct tatcggaaaa aggatctgcg gaatcagaat cgtaaaaaaa 349441 gacggatcac aggtcagtct gttaacaatg tttttacggg ttattgtagc cggcctggtt 349501 tactgtataa ccttcggact cggcttgatc gccagcctga ttctgattgc cgtacgagaa 349561 gacaaacgga ccctgcatga tttaatcgcg ggaacatatg tcacttatgc gacaccaggt 349621 gaagaggaac ttaatgctga cgaagagatt agaaagagcg aataatggtt cgctcttttt 349681 atttttatgc ataaaaaata caaggcagca aaacatatga aaaataggat tggaggaata 349741 aaatggatga aacgaataac catcaacatt atcacaatgt tcattgcagc ggctgtcatt 349801 tctctgaccg gtacagctga ggccgctgaa aaacagcagc agtctcccgc aaatgttaca 349861 ctgacagatc agcaaaagaa agagattgaa caactggaag cagagattct taaaaagcgc 349921 aaagacgtga tctcaaagta tgtacaatac ggtatcctgc ctaaagaaag aggagaacac 349981 atcaaaaatc acttggacaa acactttgaa atgatgaaac aaaacggctt tgttccaaag 350041 caccatcctc atccgcataa atttgaaaaa agacattaag attttaagca tccaatggga 350101 attgggtgct tttgcgttat ttacaggtag gcaatattag ctgagctgtt ccgcgactaa 350161 catcgagttg atatgaaacg cgtttcatag cctatgatag gtttatcaaa taattcagga 350221 gtgataaaca ctatgatcca ccagcatcca gaatcttttc cgaaacattt tttgtggggc 350281 tctgcttctg cagcgtacca gattgaaggc gcttggaatg aagatggcaa aggcccttct 350341 gtttgggatg tgtttacgaa aataccgggc aaaacgttta aaggaaccaa tggcgagatt 350401 gcggttgacc attatcaccg atttaaagaa gatgtcgctc tgatggctga gatggggtta 350461 aaagcatatc gattttccgt cagctggcca cgggtttttc caaaaggaaa aggagagatc 350521 aatgaagcag gtctagcgtt ttacgatagt ctgattgatg aattgctttc tcatcacatc 350581 gagccggttc tgactttata tcactgggat ttgcctcaag cgcttatgga cgaatacggc 350641 gggtttgaat ccagaaacat catagaggat tttaatcact actgtattac tctttataaa 350701 cgttttggag acagggtgaa atattgggtt acgttaaacg aacagaacta caattttaat 350761 cacggattta ttacagccat gcatccgcct ggagtgaaag acagaaaacg attttacgaa 350821 gcaaaccata ttgcgtttct ggctaatgca aaagccatcg aatcatttag agaatatgtg 350881 cctgaaggca aaataggtcc tagctttgct tattctccgg cttacccttt atcaagtcat 350941 ccagaggata tactggcatt tgaaaacgcc gaagaattta cgaacaattg gtggcttgac 351001 atgtattgct ggggaaccta cccgcaaatt ccattccgct gcttggaaaa acagggatgg 351061 gcgccgacaa ttgaagcagg agatatggac ctgctcgcca aagggaagcc tgattttgta 351121 ggtgtcaatt attatcagac gatcacctat gaacgaaatc cgcttgatgg tgtgtcagaa 351181 gggaaaatga atacgacagg ccaaaaggga accaatcagg agacggggat acccggagtg 351241 ttcaaaacga aaaaaaatcc gcatctgaca acgagcaact gggattggac aattgaccca 351301 attgggctgc gtatcggtct tcgccgaatt acaagccgct atcagcttcc agtgtttata 351361 acagagaacg gtttgggtga atttgataaa gttgaggacg gcactgtaca ggatgattat 351421 cgaattgatt atttgcgttc gcatcttgag caatgcagac aagccatcag tgacggtgtc 351481 gatttaatcg gctattgcag ctggtcgttt actgatctgt taagctggct gaacggctac 351541 caaaaaagat acggatttgt atatgtcaat cgtgatgaag aaagcacatc cgatttaaaa 351601 cgcttgaaga aaaaaagctt ttattggtat caagatgtca tcaagacaaa cggagaaagt 351661 ttataaagag tccctgagag ttattctctc aggggttttt cattacacag aaacagcatc 351721 aataatataa gtgtcggcgt gcaaatctga catttcagcc ggcacagtcc agcatgtcaa 351781 ttgatagtct cctttaggca gatcaaagga cagtctttta gacatgatgc tttcaatatg 351841 aattccgttt tctgtgacat gaaaaggaac agtcactttt ttttcgtagg agtttactgt 351901 ttctgaactg ttcaggcgaa aaagaataaa ggcctttgta tttcgctgtg cctcaaagga 351961 aatggctccg tctgccgcag catatccttt ttcaatcgct tcgtcagtcc aatccattac 352021 aggaggtgta gaatcctttt gaaatacagt aaattgatga tatgaaatcg aaagttcttg 352081 cggcttccat gatttgatca atgtgctgtt cctcctctat gtactgttta ctgaattgtg 352141 aataaaacct ttgtgccgtc tgggtaatcg gtaagccgat gcccgaccca agagcctgct 352201 ccgcggttgt cagcgggaga aatgtattct acagaagctc cctcaccgcc ttctttgcac 352261 atggccattg gccattcatc tctgtcatac ccctttttgg aaggtacgtc ctttaatgat 352321 tgctcgcggc gttcttcagc tccgtctctg tcaatagtgc acacctctga gtgcccctca 352381 tttatcgcat ccttaatatg cttggcagtt tcgggatacc ggtcagatgg gaaggccatt 352441 gtttcatcat attctttcgt ttgagacgtt ttttgatcag ctgagaaaaa gtctcctttt 352501 atcaggccga cagctgcagc tgctatgatg acgatgacga gaagtatcgt ttttatgatg 352561 tccgtcgtga tgttcacctc ccgcttttaa aactgacaca agagtaatcc agaaagcatt 352621 tggtgtaaag gtttaaattt tatgttttac gatcagttta ttgcagaaat cgtaatttta 352681 gcagatcgaa atatttgttt tcagcaaaat acgattgcca atttacaata atgatagtaa 352741 gtcatcagcc gttttcggct tgattaatca ttttaaattg gcttatgata ccggtaagct 352801 cctcagctaa ttgagaaagt gtttcagaag ctgcggtaat ctcctccatt gcagcaaatt 352861 gctcctctgt taatgcagcc gcttgccggg tatttttagt agattcttta atgtcggccg 352921 tattggctgc aaaggaatca tttatttgat gtgcactggc tgaaatgttt gttacagatg 352981 ctgataaatc actaatctcg gcgctgattt cacctgttgc agctgcaatt tccttaaatg 353041 catctctggt gcgctggatc atggtgactc cttctgcagc ttctgttttc acatgctcaa 353101 cagatcttgc agaccggttc atatcctttt gtatttctat gatcagtttt gaaatctgcc 353161 ccgcagactg ttgagactct tctgctaatt tccgtacttc atcagcaaca acagcaaagc 353221 cttttccttg ttcaccggct ctggcagctt caatcgctgc attcagcgca agcaggtttg 353281 tctgatcagc aatttgggtg atgaccgata aaatttgctc aatttgttta gagcggccgt 353341 ctaactggtg tatgatttct ccgcttttct gaattgactg gtgaatcgca tccatttgcg 353401 cctgtacatt tgcaatttcc ttttgtccaa tgtctgcttt tgattgagcg agctgccctt 353461 tgtcagcgat agcggcagta tttgcagaaa tatcccggat gtctgctgaa gcttgtttta 353521 atgagctttc actattttca attcgggtga tctgatcttg ggctccattt gcaatctgct 353581 gtacagcttc tgtgattttt tctgaagctt gatttgtttc ctctgctccg gctgagagct 353641 gctgagaggc tgacgcaagc tgaagggctg attgttgtac ggtttgtatg gtatcgttca 353701 gcttcattct catcttatta taatagacgc ttagttctga aagctcgtca ccggttttgt 353761 ctgacacctc tattgtcata tctccgtttc cggcactttc aaaggcgctt tttaaagcgt 353821 tcagccgctt gttgattttt ctggtgaaaa ccaagacaag gatgactgat accataatga 353881 cgataacaag aacgatagcg aattgagtga aaagtgattg tgtaagtgat gctaaaatac 353941 tttgattagc tccggtatac agcatgccga tgatgttccc attttgatct tttaacggca 354001 tgtatgcagt ctgataagaa gaacctgcta catctgcttg tccgtaaaaa cgctttcctt 354061 tctttaaaac agcggcaata acttcagaag aagcctgggt gccgacggct ctttcgccat 354121 ttttcatgac attggttgca acacgagtat cgccttggaa aatggtaatg gtatcacctg 354181 tcttttcacc aagcagatca acaatatctt catttccatt gatttgtgtt tgccctttat 354241 agagcttatt gtttttcacc tgccagtcgc ctgacatgac atcatcaata taagtgctgc 354301 ttaaagcgag atcacctttc gctttttcag ttgccatttg tttcatgctt tctgtaattt 354361 ccttaagcat cacagtgcca actgatgccg aaaacaaaag aatcaccacg aaaacgaggc 354421 aaagaatttt agttcctagc ttcatcttaa atcgttttat caacataatt cctcccttta 354481 cgatttgcag gtcatattac ttatcgggtt tttgggttta aagttttatt ttagaaaaaa 354541 taaaaccggc ctgatcttca ggccggttgt gtgatgctat tcaaggtttg cgtggtgagt 354601 gaacatagtt tcagaatcga gacctttttt ctccatgagt tttaaaatca ctgcatcata 354661 gaagagcagc aaagtttgtt caaataatga tcccattggc tgaatggttt tatagcttcc 354721 gttagactgg tctttagggg aaccaggcat tctgatgatg aggtccgctt gttttccgat 354781 gcttgattcc ggattgatgg ttaaagcggc aacaattccg tgtaagcttt ttgcttttgc 354841 tgcggtatga atcaagctct ttgtctcgcc tgatcctgag ccgataataa ctagatctcc 354901 ttcggcgagc ggcggagtga gaatctcacc tactatatgg gcgttgaagc ccatgtgcat 354961 cagtctcatc gcgaaggatt ttgccatcag gccagaccgc cccgcacccg cggtgaaaat 355021 ttggtgggat gaaagaatgt gatcggcaag ctggtcagct tcttcattag aaatataagc 355081 tgctgaattg tgtaactcat tgagaatttc cgctacgtat tcagtcgttt tcatcggagt 355141 tatccttgga caatcagctg cttcattttt gaagctgttt ccgccttatc agctgcgctt 355201 gtaattccgc ccccgacaat gacaaggtca ggcttttgct ggatcacttc tggcagtgta 355261 tcaagtttga tgccgcccgc gattgcggtt tttgcgtttt ttacggtatt tttgattgtc 355321 gttaattctt cgaaagagtt tttgccctct gcttgaagat catagccagt gtggacgcag 355381 atgtagtcaa caccgagtgc gtcaatttct ttcgcacggg attcgatatc tttcacgtta 355441 atcatgtcca ctaagatttt cttcttttgt tttttggctt cttctactgc gcctttaatc 355501 gttgcatcgt ctgtagcccc taaaacggtg atgatgtcag cgcctgcttc cgacgctttc 355561 ataatttcgt agcctccggc atccatgatt ttcaggtctg caagaacctt caattgagga 355621 aatgcttctt ttatttcttt aacggctctt aggccttcat tgatgacgac cggtgttccg 355681 atttcaacta cgtcgatgta ttgttctacc tctttgacaa gctcaatggc ttccgggatg 355741 ttgacgaggt ctaatgcaag ctgtaattcc attgttgatc cactcccttt ttcgaattat 355801 tgttcattct ataggttcct tcttttgttg agaagtaggc actttgaagt caacaagtta 355861 cttggaggat actgtgagga gagacaatca gatttctttc gcttgatttt atgagtgagt 355921 ataatgaaaa aagagtctgc aaaaaagtaa gtaagtgatg atacgtatct aacatacaaa 355981 aaggttacta agggggggga ttctattgag ccggatggac gacaaaaggt ttaattgtga 356041 gaaggaatta acgcttgcag tgattggcgg taaatggaaa atgctcattt tatggcattt 356101 aggaaaagaa ggcacaaaac ggttcaatga attaaaaaca ttgattcctg atattacgca 356161 gaagatcctc gtgaatcagc tgagagagct tgagcaggat atgattgttc acagggaagt 356221 gtatccagtt gtcccgccga aggttgaata ttctctgacc ccgcacggag aaagcctcat 356281 gcctattctt gaagccatgt atgagtgggg gaaaggctat atggaattga ttgatatcga 356341 caaaaatgtc atgaaagaat cgttgtaaga cgctcttcgc aagggtgtct ttttttgcct 356401 ttttttcggt ttttgcgcgg tacacatagt catgtaaaga ttgtaaattg cattcagcaa 356461 taaaaaaaga ttgaacgcag cagtttggtt taaaaatttt tatttttctg taaataatgt 356521 ttagtggaaa tgattgcggc atcccgcaaa aaatattgct gtaaataaac tggaatcttt 356581 cggcatcccg catgaaactt ttcacccatt tttcggtgat aaaaacattt ttttcattta 356641 aactgaacgg tagaaagata aaaaatattg aaaacaatga ataaatagcc aaaattggtt 356701 tcttattagg gtggggtctt gcggtcttta tccgcttatg ttaaacgccg caatgctgac 356761 tgacggcagc ctgctttaat agcggccatc tgttttttga ttggaagcac tgctttttaa 356821 gtgtagtact ttgggctatt tcggctgtta gttcataaga attaaaagct gatatggata 356881 agaaagagaa aatgcgttgc acatgttcac tgcttataaa gattagggga ggtatgacaa 356941 tatggaaata actttttacc ctttaacgga tgcacaaaaa cgaatttggt acacagaaaa 357001 attttatcct cacacgagca tttcaaatct tgcggggatt ggtaagctgg tttcagctga 357061 tgcgattgat tatgtgcttg ttgagcaggc gattcaagag tttattcgca gaaatgacgc 357121 catgcgcctt cggttgcggc tagatgaaaa cggggagcct gttcaatata ttagcgagta 357181 tcggcctgtt gatataaaac atactgacac tactgaagat ccgaatgcga tagagtttat 357241 ttcacaatgg agccgggagg aaacgaagaa acctttgccg ctatacgatt gtgatttgtt 357301 ccgtttttcc ttgttcacca taaaggaaaa tgaagtgtgg ttttacgcaa atgttcatca 357361 cgtgatttct gatggtatct ccatgaatat tctcgggaat gcgatcatgc acatttattt 357421 agaattagcc agcggctcag agacaaaaga aggaatctcg cattcattta tcgatcatgt 357481 tttatctgaa caggaatatg ctcaatcgaa gcggtttgaa aaggacaagg cgttttggaa 357541 caaacaattt gaatcggtgc ctgaacttgt ttccttgaaa cggaatgcat ccgcaggggg 357601 aagtttagat gctgagaggt tctctaaaga tgtgcctgaa gcgcttcatc agcagattct 357661 gtcgttttgt gaggcgaata aagtcagtgt tctttcggta tttcaatcgc tgctcgccgc 357721 ctatttgtac agggtcagcg gccagaatga tgttgtgacg ggaacattta tgggcaaccg 357781 gacaaatgcg aaagagaagc agatgcttgg catgtttgtt tctacggttc cgcttcggac 357841 aaacattgac ggcgggcagg cgttttcaga atttgtcaaa gaccggatga aggatctgat 357901 gaagacactt cgccaccaaa agtatccgta taatctccta atcaacgatt tgcgtgaaac 357961 aaagagctct ctgaccaagc tgttcacggt ttctcttgaa tatcaagtga tgcagtggca 358021 gaaagaagag gatcttgcct ttttgactga gccgattttc agcggcagcg gattaaatga 358081 tgtctcaatt catgtaaagg atcgatggga tactgggaaa ctcaccatag attttgatta 358141 ccgcactgat ttattttcac gtgaagaaat caacatgatt tgtgagcgca tgattaccat 358201 gctggagaac gcgttaacgc atccagaaca tacaattgat gaattaacac tgatttctga 358261 tgcggagaaa gagaagctgc ttgcgagggc cggcggtaaa tctgtgagct accgtaagga 358321 catgacgata ccagagctgt tccaagaaaa ggctgaactg ctttctgatc atccagcggt 358381 tgtatttgaa gatcgcacat tgtcctatcg aacgttacat gagcaatctg cacgcatcgc 358441 caatgtgctg aaacagaaag gggttggccc ggacagtcct gtcgcggttt tgattgaacg 358501 ctctgaacgg atgattacag ctatcatggg aattttaaaa gccggcggag cctatgtgcc 358561 gattgatccg ggttttcctg ctgagcgcat tcaatatatt ttggaggact gcggggcgga 358621 tttcatcctg actgaatcga aggttgcggc gcctgaagcc gatgctgagc tgattgactt 358681 agatcaggcg attgaggaag gtgcagaaga aagcctgaat gcagatgtga acgctcggaa 358741 ccttgcctac attatttaca catcgggaac aaccggacgc ccgaaaggcg ttatgatcga 358801 gcatcgccag gttcatcatt tggttgaatc tctgcagcag acgatttatc aaagcggcag 358861 ccaaaccctg cggatggcat tgcttgcgcc gttccacttt gatgcgtcag tgaagcagat 358921 cttcgcgtcg cttcttttgg gccaaaccct ttatatcgta ccgaagaaaa cagtgacgaa 358981 cggggccgcc cttactgcat attatcggaa gaacagcatt gaggcgacgg acggaacacc 359041 ggctcatttg caaatgctgg cagcagcagg cgattttgaa ggcctaaaac tgaagcacat 359101 gctgatcgga ggagaaggcc tgtcatctgt tgttgcggac aagctgctga agctgtttaa 359161 agaagccggc acagcgccgc gtttgactaa tgtgtacggg ccgactgaaa cgtgcgttga 359221 cgcgtctgtt catccggtta tccctgagaa tgcagttcaa tcagcgtatg tgccgatcgg 359281 gaaagcgctg gggaataacc gcttatatat tttggatcaa aaaggccggc tgcagcctga 359341 aggcgtggcg ggtgagcttt atatcgcggg agacggtgtg ggccgaggct atttacattt 359401 gcctgaatta acggaagaga agtttttaca agatccattc gtgccgggcg atcgcatgta 359461 ccggaccggg gacgtggtgc gctggcttcc agatggaaca atcgaatatt taggcagaga 359521 ggatgaccag gtcaaagtcc gcggataccg gattgagctt ggggaaattg aagccgtgat 359581 tcagcaggcg ccagacgttg caaaagccgt tgttttggca cgccctgacg aacagggaaa 359641 tcttgaggtt tgcgcatatg ttgtgcagaa gcctggaagc gaatttgcgc cagccggttt 359701 gagggagcat gcggccagac agcttcctga ctatatggtg ccggcttact ttacagaagt 359761 gacagaaatt ccgcttacac caagcggcaa agtcgaccgc cgcaagctgt ttgcactaga 359821 ggtgaaggct gtcagcggca ctgcctatac agcgccgcga aatgagactg aaaaagcaat 359881 cgcagccatt tggcaggacg tgctgaacgt tgagaaggcg gggatctttg acaatttctt 359941 tgaaactggc ggacattcat taaaagccat gaccctttta acaaagattc ataaggaaac 360001 aggcattgag attccgcttc aatttttgtt tgagcatccg acgattacgg ctcttgcaga 360061 ggaagctgat cacagagaaa gcaaagcttt tgcggtgatt gaacctgctg aaaaacagga 360121 gcattacccg ctttcattgg cacagcagcg aacatatatc gtcagccagt tcgaggatgc 360181 gggagtcggc tataacatgc cagcagcagc aattctggaa gggcctttag atattcaaaa 360241 gctggagcgc gcatttcagg gattaatccg acgccacgag tcattgagaa catcatttgt 360301 tcttgaaaac agcacgccga gacagaaaat tcacgatagc gttgatttca acatcgaaat 360361 gattgaaaga ggcggccgct cagatgaggc aattatggct tcattcgttc ggacatttga 360421 tttggcgaaa gctccgctgt tcagaatcgg tttgctgggg cttgaagaga accgtcatat 360481 gctgctgttt gacatgcacc atttgatttc tgacggtgta tccattggca ttatgctgga 360541 ggagttagca cgcatttata aaggcgaaca gcttcctgat cttcgtctcc agtataagga 360601 ctacgctgta tggcaaagca gacaggctgc tgaagggtac aagaaggacc aggcttattg 360661 gaaggaagtc tttgcaggcg agctcccggt gcttcagctt ctgtccgatt acccaagacc 360721 acctgttcaa agctttgaag gggatcgggt gtcaatcaag ctggatgcgg gggtaaagga 360781 tcgcctcaat cgtttggctg aacaaaacgg cgccacttta tatatggtga tgctttccgc 360841 ttactatacg cttttgtcaa agtatacggg gcaggatgac atcattgtcg ggacaccgtc 360901 agcgggcaga aatcactccg atacagaggg cattatcggg atgttcgtca atacgcttgc 360961 gattcgcagt gaggtgaagc agaatgagac gtttacccaa ttgatctcgc gtgtccgcaa 361021 acgggtgctg gatgcctttt ctcatcagga ctatccgttt gagtggcttg ttgaagattt 361081 gaacatcccg cgtgatgtta gcaggcatcc gctgtttgac acgatgttca gccttcaaaa 361141 cgcgacagag ggcattccgg ctgtcggcga tctttccttg tctgttcaag agaccaattt 361201 caagattgcc aaatttgatt tgacggtgca ggcgagagaa accgatgaag gcattgagat 361261 tgatgtggat tacagcacaa agctgtttaa acaaagcacg gcagacaggc tgcttacgca 361321 ttttgcgcgt ttgcttgaag atgctgcggc tgatccagag aagccgattt ctgagtataa 361381 gcttctttct gaagaggagg ctgcttcgca aattcagcag tttaacccgg gcagaacacc 361441 ttatccgaaa gataaaacaa ttgttcagct gtttgaggag caagcggcga atacgccaga 361501 ccacactgcg cttcaatatg aaggcgaatc actcacttat cgtgaactga atgaacgggc 361561 caatcgttta gcccgcggca ttctttctct tggagctggc gaaggcagaa ctgcggctgt 361621 cttatgcgag cggtcaatgg atatgattgt gtcgatcttg gcagtattaa aatcaggttc 361681 ggcttatgtt ccgatcgatc cggaacatcc gattcagcgg atgcagcatt tcttccgtga 361741 cagcggagca aaggtgcttc tcactcagag gaaattaaag gctttggcgg aagaagcgga 361801 atttaagggc gttatcgtgc tagccgatga ggaagaaagc tatcatgccg atgcgcgaaa 361861 tctcgcactg cctcttgatt ctgcagcaat ggccaacctg acgtatactt ccggaacgac 361921 tggaacacct aaggggaata tcgtgacaca tgccaatatt ctccgcacgg tgaaggaaac 361981 gaattatctc agcattacag aacaggatac gattctcggt ctttccaatt acgtgtttga 362041 cgcgtttatg ttcgatatgt tcggctcttt gttaaacgga gccaagctgg tgctgatacc 362101 gaaggaaacc gttttggaca tggctcgcct gtcccgcgtc attgaacggg agaacatcag 362161 cattctcatg attacaaccg ctttgttcca cttgcttgtg gacttgaatc cggcatgctt 362221 gtcaacgctt cgcaagatta tgtttggcgg ggaacgggct tcggttgagc atgtcagaaa 362281 agctttgcaa acggttggaa agggcaagct ccttcatatg tatggaccgt ctgaaagcac 362341 ggttttcgcg acgtatcatc cggttgatga attggaggag cacacgctgt ctgttccgat 362401 tggaaaaccg gtcagcaata cggaagtata cattcttgac cgtacgggac acgtgcagcc 362461 tgccgggatt gccggagagc tttgcgtcag cggcgaagga ctcgtgaaag gctattacaa 362521 ccgtccagaa ctgactgagg agaaatttgt tccccatccg tttacatccg gcgaacgcat 362581 gtataaaacg ggagaccttg cgagatggct gccgaatggc gacatcgaat ttatcgggcg 362641 aatcgaccat caggtgaaga ttcgcggaca gcgcatcgag cttggagaaa tcgaacatca 362701 gctgcaaacc catgatcgtg ttcaggaaag tgttgtgctt gccgttgatc aaggagcggg 362761 agataaactg ttgtgtgctt actatgtcgg agaaggagac atctcatcac aagagatgag 362821 agagcatgct gcgaaggact tgccggcata tatggttcct gcggtgttta tccaaatgga 362881 cgagctgccg ctgacaggga acggaaaaat tgaccggaga gcgctgccga ttcctgatgc 362941 caacgtttca agaggtgttt catatgttgc gccacgcaat ggaacggaac aaaaagtcgc 363001 ggacatttgg gcacaggtac ttcaggcaga acaagtcggc gcttatgacc acttctttga 363061 cattggcgga cattcattag caggcatgaa gatgcttgcc ttggttcatc aggaactggg 363121 cgttgagctg tcactcaagg atctcttcca gtcaccgacg gttgagggct tggcacaggt 363181 gattgcctct gctgaaaaag ggacagccgc aagtatcagc ccggcagaga aacaagatac 363241 gtatcctgtt tcttcaccgc aaaaacggat gtacgtgctt cagcagcttg aggatgcgca 363301 aacgagctat aacatgccgg cggttctgcg cctgacaggt gagcttgatg ttgaaaggct 363361 taacagcgtc atgcagcagt taatgcagcg tcatgaagcc ttgagaacca cgtttgaaat 363421 aaaagatgga gaaacggtgc agcggatctg ggaagaggct gagtgcgaga tagcctattt 363481 cgaagccccg gaagaagaga cagagcggat cgtttctgag tttattaagc ctttcaaaat 363541 cgaccaactt ccactgttca gaatagggct tatcaagcat tcagacactg agcatgtgct 363601 gctgttcgat atgcatcata ttatttctga tggtgcatct gtcggtgtgc tgattgagga 363661 gctttcaaag ctgtacgacg gagaaaccct tgagccgctc cgtattcaat ataaggatta 363721 tgccgtgtgg cagcagcagt tcattcagtc tgagctttac aagaagcaag aagagcattg 363781 gctgaaggag ctggacggag agctgccggt gctgacgctt ccgactgatt acagtcggcc 363841 tgccgttcaa acatttgagg gagaccgcat tgcattttca ttagaagcag gcaaagctga 363901 tgctctgcgc aggcttgcaa aagaaacgga ttccacgctt tacatggtgc ttctggcttc 363961 atacagtgcg tttttatcaa aaattagcgg gcaagacgat atcatcgtcg gttcacctgt 364021 ggccggacga tctcaagcgg acgtcagccg cgtcatcgga atgttcgtca atacattggc 364081 gctgcgcacg tatccgaagg gtgaaaagac gtttgctgac tatcttaacg aagtgaaaga 364141 aacggcactc agcgcttttg atgcgcagga ttacccactt gaggatttga tcggaaatgt 364201 tcaggttcag cgtgacacaa gcagaaatcc gttattcgat gcagtttttt caatgcaaaa 364261 tgcgaatata aaggatttaa caatgaaagg gattcagctt gagccgcatc cgtttgaacg 364321 gaaaacagcc aagtttgacc tcacgctgac ggctgacgaa accgacggag ggcttacatt 364381 cgtactcgaa tacaatacag ctctgtttaa gcaggaaacg attgaacgat ggaagcaata 364441 ttggatggag cttttagatg cagttactgg gaacccgaac cagccgcttt ccagcctgtc 364501 actggtcacc gagacagaaa agcaagcgct tcttgaggca tggaagggca aagcgctgcc 364561 tgtgccgaca gacaaaacgg ttcatcagct attcgaagag actgcccagc gccacaaaga 364621 ccgcccggct gtcacataca acggccagtc ttggacgtac ggcgagctga atgcgaaggc 364681 aaaccgtctc gcgcggattc tgatggactg cggcatcagc ccggatgacc gcgtcggcgt 364741 tctcacgaag ccgtcgcttg aaatgtccgc cgcggtgctc ggcgtcttga aagccggagc 364801 ggcgtttgtg ccgattgatc ctgactatcc ggatcagcgg attgagtata ttttacagga 364861 cagcggcgcg aagcttctct tgaaacagga aggcatttca gtgccggaca gctatacggg 364921 agatgtcatt cttctcgacg gaagccgcac gattctaagc ctgccgcttg atgaaaacga 364981 cgaggaaaat ccagaaaccg ctgtaaccgc ggagaacttg gcgtacatga tttacacgtc 365041 tggaacgacc ggacagccga agggtgtcat ggtcgagcac catgcgcttg tgaacctgtg 365101 cttctggcac cacgacgcgt tcagcatgac agcggaggac cgcagtgcga agtacgcggg 365161 ctttgggttc gacgcttcca tttgggagat gttcccgacc tggacgatcg gtgccgaact 365221 tcacgtcatt gaggaagcga tccgcctcga tatcgtccgc ctgaacgatt attttgaaac 365281 gaacggcgta acgatcacgt tcctgccgac acagcttgcg gaacagttca tggagcttga 365341 gaacacatca cttcgcgtat tgcttactgg aggagacaag ctgaagcgcg cagtgaaaaa 365401 gccgtacaca ctcgtcaata actacgggcc gacagagaat acggtcgttg ccacaagcgc 365461 agaaatccat ccggaggaag gctcgctttc catcggaagg gccattgcca atacgagagt 365521 atacattctc ggcgagggca atcaggtgca gccggaaggc gtagccggag agctttgcgt 365581 ggcggggcgc ggactggcac gcggctatct gaatcgagaa gacgaaaccg cgaagcggtt 365641 tgtcgctgat ccgtttgtgc cgggtgagcg catgtaccgc accggcgatt tggtgaaatg 365701 gacgggcggc ggcatcgaat acatcggccg gatcgaccag caggtcaagg tccgcggcta 365761 ccggatcgag ctctcagaaa ttgaagtcca gctcgcccag ctttctgagg tgcaggatgc 365821 ggcggtgaca gctgtcaaag ataaaggcgg caacacagcg atcgcggcgt atgtcacacc 365881 ggaatcagct gacatagaag cactgaaatc agcactgaag gaaaccctgc cggattacat 365941 gatcccggcg ttctgggtga cgctgaacga gcttccggtt acggcaaacg gcaaagtgga 366001 ccgcaaagcc ttgcctgagc cggacatcga agcgggaagc ggagaataca aagcgccgac 366061 gaccgacatg gaagagctgc ttgccggcat ctggcaggac gtgcttggaa tgtctgaagt 366121 cggtgtcacc gacaatttct tctcgcttgg cggagattcc atcaaaggaa ttcaaatggc 366181 gagccgcttg aaccagcacg gctggaagct ggaaatgaaa gatctcttcc agcacccgac 366241 gatcgaagag ctcacccagt acgtagagcg tgccgaaggc aaacaggcag accaaggccc 366301 ggtggagggc gaagtcatcc tgacgccgat ccagcgctgg ttctttgaaa agaacttcac 366361 gaacaagcac cactggaacc aatctgtgat gcttcacgcc aagaagggct ttgatcctga 366421 acgggtggag aaaacattgc aggcgctgat cgagcatcat gacgcgctcc gcatggtcta 366481 tcgtgaggga caggaagacg tcattcaata caacagaggt cttgaagctg cttcagctca 366541 attggaggtc atccagattg agggccaagc tgcagattac gaagaccgaa tagagagaga 366601 agcggagcgt ttgcaaagca gcatcgactt gcaggaaggc ggcttgttaa aagcaggctt 366661 gttccaagcg gaagacggag atcacttgct tcttgccatt caccacttag tggttgacgg 366721 cgtgtcgtgg cggattttac tggaggattt cgccgcggta tatacacagc ttgagcaagg 366781 caatgaaccg gttctcccgc agaaaacaca ttcatttgca gagtatgcag agagattgca 366841 agacttcgcg aactccaaag cctttttgaa agaaaaagag tattggagac agcttgaaga 366901 acaagctgtt gcggcaaagc ttccgaaaga ccgcgaatct ggtgatcagc gaatgaaaca 366961 tacaaagaca attgaattct cgctgactgc tgaagagaca gaacagctca ccacaaaggt 367021 gcatgaggca tatcacacag aaatgaatga tattttgctg acggcattcg gattggcaat 367081 gaaggagtgg acgggtcaag atcgagtaag tgttcattta gaggggcatg gacgtgaaga 367141 aatcatagaa gacctgacca tttctcgcac agtcggctgg tttacaagta tgtacccaat 367201 ggtgctcgat atgaagcatg cggatgatct gggctaccag ctgaagcaaa tgaaagaaga 367261 tatcagacat gtgccgaata agggagtcgg atacggcatt ctgcgctatc tgacggcacc 367321 ggaacataaa gaagatgtgg cgttctcgat tcagccggat gtcagcttca actatttagg 367381 tcagtttgac gaaatgtcgg atgcaggttt gtttacgaga tcagagctgc catcaggaca 367441 gtcattaagc cctgaaacag aaaaaccgaa tgcgctggat gttgtcggat atatcgaaaa 367501 cggaaaactg acgatgtcac tggcctatca ttctcttgaa tttcatgaaa aaacagtaca 367561 aacattcagt gacagcttta aagcgcatct tctcagaatc attgaacatt gcctatctca 367621 agatggtacg gaactgaccc cgagtgatct tggtgacgac gatttgacgc tggatgagct 367681 ggataaatta atggaaattt tctaatagag gtggcatatg agcaaaaaat cgattcaaaa 367741 ggtgtacgca ctgacaccaa tgcaggaggg aatgctgtat catgcgatgc ttgatccgca 367801 ttcttcctcg tacttcacac aattagagct tgggattcac ggcgcttttg atcttgaaat 367861 ctttgagaaa agcgtcaatg aactgattcg gtcatacgat attctccgta cggtatttgt 367921 gcatcagcag ctgcaaaaac cgcgtcaggt cgtgttagcg gaacgcaaaa caaaagtgca 367981 ttatgaggat atcagtcatg cagacgaaaa ccgccagaaa gagcacattg agcgttacaa 368041 acaagacgtt cagcgccaag gctttaacct ggcaaaagac atattgttca aggtagcggt 368101 tttccgcctt gctgcagatc agctgtatct tgtctggagc aatcatcata ttatgatgga 368161 cggctggagc atgggcgtcc tcatgaaaag cctgttccaa aactatgaag cgctcagagc 368221 aggcaggaca ccggcaaacg gtcagggcaa gccttattcc gattacatca agtggcttgg 368281 aaaacaggac aatgaagaag cggagagcta ctggagcgag cgcttggcgg gttttgaaca 368341 gccaagcgtg ctcccgggcc gcctgcctgt gaaaaaagac gaatacgtca ataaagaata 368401 ttcatttaca tgggacgaaa cactggttgc ccgtattcag caaaccgcaa atctccatca 368461 agtgacaggg cctaacctat ttcaggccgt ttggggcatt gttctcagca aatacaactt 368521 tacggatgat gtgatcttcg gaacggtcgt ctcgggacga ccgtctgaaa tcaacggaat 368581 cgaaacgatg gcggggctgt ttatcaacac cattccagtg cgggtgaaag ttgaacgaga 368641 tgctgcattc gctgatattt tcacagctgt tcagcagcat gcagtagagg cagagcgtta 368701 cgattacgtg ccgctctatg agattcaaaa acgctcagct cttgatggca atctcttaaa 368761 ccatctggtc gcgtttgaaa attatccgct tgatcaagag cttgaaaacg gcagcatgga 368821 agaccgcctc gggttttcga ttaaggtaga aagcgcattt gaacaaacga gcttcgattt 368881 caacctgatt gtgtatccgg gcaaaacgtg gaccgtcaaa attaaatata acggagccgc 368941 ctttgattcc gcttttatcg aacggacagc ggagcacctt acccgcatga tggaagcagc 369001 tgtcgatcag ccggccgctt ttgtgcgtga gtacgggctt gtgggagacg aagagcagcg 369061 gcaaattgtc gaggtgttta acagcacgaa agccgaactc cctgaaggaa tggctgttca 369121 ccaagtgttt gaagagcaag cgaaacggac gccggcgagc accgccgtcg tatatgaagg 369181 aaccaagctg acgtaccgcg agctgaatgc agcggctaac cgtctggcga gaaagcttgt 369241 cgaacatggg cttcaaaaag gggaaacagc agcgattatg aacgaccgct cagtagaaac 369301 cgttgtcggc atgctggctg ttttaaaagc aggcgccgca tatgtgccgc ttgatccagc 369361 gcttcctggg gatcgtcttc gtttcatggc agaggacagc tccgttcgaa tggttttgat 369421 cggaaattct tatacagggc aggcacatca gctgcaagtg ccggttctta cactggacat 369481 aggctttgaa gagagtgaag cggctgacaa tctcaacctg ccatccgccc cgtctgattt 369541 ggcgtacatc atgtacacat ccggttcaac gggcaaaccg aaaggcgtca tgatcgaaca 369601 taaaagcatt ctgcgcctcg tcaaaaatgc cgggtacgtt cctgttactg aagaagaccg 369661 catggcgcaa acgggagctg tcagctttga tgccggaacg tttgaggtat tcggcgcact 369721 gctgaatggc gcagcacttt atccggtcaa aaaagagaca ctgcttgatg cgaaacaatt 369781 tgctgcattc ctgcgtgagc aaagcatcac aactatgtgg ctgacatcac ctttattcaa 369841 ccagcttgct gcaaaggatg cgggtatgtt cggcacactg cgccatttaa tcatcggcgg 369901 agatgccctt gtcccgcata ttgtcagcaa agtaaaacag gcatcgccgt cgctttcatt 369961 gtggaacgga tacggcccga cagaaaacac gacgttttca accagttttc tgatcgaccg 370021 cgagtatggc ggctctatcc caatcgggaa gccgatcgga aattccactg cctatattat 370081 ggatgagcag caatgcctgc agccaatcgg cgcgcctggt gagctttgcg taggcggaat 370141 cggtgtagcg cgtgggtatg tcaatctccc tgagctgacg gagaagcaat ttctggaaga 370201 cccgttcaga ccgggtgaga gaatttaccg cactggtgac ttggcaagat ggctgccgga 370261 cggcaatatc gaatttttag gcagaatcga caaccaagtg aaggtgcgcg gcttccgaat 370321 tgagcttggc gaaattgaaa caaaactgaa catggctgag catgtgacag aagccgcggt 370381 gatcatacgc aagaacaaag cagacgaaaa tgaaatttgc gcgtacttca cggcggatcg 370441 tgaagtggct gtgagtgagc tgagaaaaac actgtctcag tctttgcctg actatatggt 370501 ccctgcccac ctgattcaaa tggacagcct gccgctcacg ccaaacggga aaatcaacaa 370561 aaaggaactg cctgcaccgc aatcagaagc cgtgcagccg gaatacgcag caccaaaaac 370621 agagagtgaa aagaaattag cggagatctg ggaaggaata ctcggcgtca aagcaggcgt 370681 taccgataac ttctttatga tcggcggcca ttctttgaaa gcgatgatga tgacggcgaa 370741 aattcaagag cattttcata aggaagttcc gataaaagtg ctttttgaaa agccgactat 370801 tcaagaactg gcactgtatt tggaagagaa cgaaagcaag gaggagcaga cgtttgaacc 370861 gatcaggcaa gcatcttatc agcagcatta tcctgtatcc ccggcccagc ggagaatgta 370921 tatcctcaat cagcttggac aagcaaacac aagctacaac gtccccgctg tacttctgct 370981 ggagggagaa gtagataaag accggcttga aaacgcgatt cagcaattaa tcaaccggca 371041 cgaaatcctc cgtacatcgt ttgacatgat cgacggagag gttgtgcaaa ccgttcataa 371101 aaacatatcg ttccagctgg aggctgccaa gggacgggaa gaagacgcgg aagagataat 371161 caaagcattt gttcagccgt ttgaattaaa ccgcgcgccg ctcgtccgtt cgaagcttgt 371221 ccagctggaa gaaaaacgcc acctgctgct cattgatatg catcatatta ttactgacgg 371281 aagttcaaca ggcattctaa tcggtgatct tgccaaaata tatcaaggcg cagatctgga 371341 actgccacaa attcactata aagattacgc agtttggcac aaagaacaaa ctaattatca 371401 aaaagatgag gaatactggc tcgatgtctt taaaggcgaa ctgccaatac tggatcttcc 371461 cgcggatttc gagcggccag ctgaacggag ctttgcggga gagcgcgtga tgtttgggct 371521 tgataagcaa atcacggctc aaatcaaatc gctcatggca gaaacagata cgacaatgta 371581 catgtttttg ctggcggcgt tcaatgtact cctttccaag tacgcgtcac aggatgatat 371641 cattgtcggc tcgccgacag ctggcagaac acatcctgat ctgcaaggtg tgccgggtat 371701 gtttgtcaac acggtggcac tcagaacggc accagcggga gataaaacct tcgcgcaatt 371761 ccttgaagag gtcaaaacag ccagccttca agcattcgag caccagagct atccgcttga 371821 ggagctgatt gaaaagcttc cgcttacaag ggatacaagc agaagtccgc tgttcagcgt 371881 gatgttcaac atgcagaata tggagattcc ttcattaaga ttaggagatt tgaagatttc 371941 ctcgtattcc atgcttcatc atgttgcgaa atttgatctt tccttggaag cggtcgagcg 372001 tgaagaggat atcggcctaa gctttgacta tgcgactgcc ttgtttaagg acgagacgat 372061 ccgccgctgg agccgccact ttgtcaatat catcaaagcg gccgcggcta atccgaacgt 372121 tcggctgtct gatgtagatc tgctttcatc tgcagaaacg gctgctttgc tagaagaaag 372181 acatatgact caaattaccg aagcaacctt tgcagcactt tttgaaaaac aggcccagca 372241 aacacctgac cattctgcgg tgaaggctgg cggaaatctg ttgacctatc gcgagcttga 372301 tgaacaggcg aaccagctgg cgcatcatct tcgtgcccaa ggggcaggaa atgaagacat 372361 cgtcgcgatt gttatggacc ggtcagctga agtcatggta tccattctcg gtgtcatgaa 372421 ggcgggggca gctttccttc cgattgatcc tgatacacct gaagaacgaa tccgttattc 372481 attagaggac agcggagcaa aatttgcggt cgtgaatgaa agaaacatga cggctattgg 372541 gcaatatgaa gggataattg tcagccttga tgacggtaaa tggagaaatg aaagcaagga 372601 gcgcccatca tccatttccg ggtctcgcaa tcttgcatac gtcatttata cgtccggtac 372661 gaccggaaag ccaaagggcg tgcagattga gcatcgtaat ctgacaaact atgtctcttg 372721 gtttagtgaa gaggcgggcc tgacggaaaa tgataagact gtattgcttt catcttacgc 372781 atttgacctt ggctatacga gcatgttccc tgtacttctg ggcgggggcg agctccatat 372841 cgtccagaag gaaacctata cggcgccgga tgaaatagcg cactatatca aggagcatgg 372901 gatcacttat atcaagctga caccgtctct gttccataca atagtgaaca ccgccagttt 372961 tgcaaaagat gcgaactttg aatccttgcg cttgatcgtc ttgggaggag aaaaaatcat 373021 cccgactgat gttatcgcct tccgtaagat gtatggacat accgaattta tcaatcacta 373081 cggcccgaca gaagcaacga tcggcgccat cgccgggcgg gttgatctgt atgagccgga 373141 tgcatttgcg aaacgcccga caatcggacg cccgattgcg aatgccggtg cgcttgtctt 373201 aaatgaagca ttgaagcttg tgccgcctgg agcgagcgga cagctctata tcacgggaca 373261 ggggctcgcg agagggtatc tcaacaggcc tcagctgaca gccgagagat ttgtagaaaa 373321 tccatattcg ccgggaagcc tcatgtacaa aaccggagat gtcgtacgaa gactttctga 373381 cggtacgctt gcatttatcg gccgggctga tgatcaggtg aaaatccgag gctaccgcat 373441 tgagccgaaa gaaattgaaa cggtcatgct cagcctcagc ggaattcaag aagcggttgt 373501 actagcggtt tccgagggcg gtcttcaaga gctttgcgcg tattatacgt cggatcaaga 373561 tattgaaaaa gcagagctcc ggtaccagct ttccctaaca ctgccgtctc atatgattcc 373621 tgctttcttt gtgcaggttg acgcgattcc gctgacggca aacggaaaaa ccgacagaaa 373681 cgctctgccg aagcctaacg cggcacaatc cggaggcaag gccttggccg caccggagac 373741 agcgcttgaa gaaagtttat gccgcatttg gcagaaaacg cttggcatag aagccatcgg 373801 cattgatgac aattttttcg atttaggcgg ccattcatta aaagggatga tgctgattgc 373861 caacattcag gcggaattgg agaaaagcgt accgcttaaa gcactgttcg agcagccgac 373921 agttcgccag ctggcggctt atatggaggc gtctgctgtt tcaggcggcc atcaagtact 373981 caaaccggct gacaagcagg atatgtatcc attgtcatcc gcacagaaac gaatgtacgt 374041 gctcaatcag cttgaccgcc agacgataag ctacaacatg ccatctgttc ttctaatgga 374101 aggagagctt gatatttcgc gcctgcgcga ctcactcaat cagcttgtga accgtcacga 374161 atcattgcgg acgtcattta tggaagctaa tggtgagcct gttcagcgca tcattgagaa 374221 ggcggaggtt gatcttcatg tgtttgaagc caaagaagac gaagcggacc aaaagattaa 374281 ggaatttatc cggccattcg acttaaacga cgcaccgctc attcgcgcag ctttgcttcg 374341 aatagaagcg aaaaaacatt tgctgctttt agatatgcat catatcatcg cagacggcgt 374401 ctcaagaggc atctttgtaa aagaattggc gctgctttac aaaggagagc agcttccgga 374461 gccgacgctt cattataaag atttcgccgt ttggcaaaat gaagctgagc aaaaagaacg 374521 gatgaaggag catgaggcgt actggatgtc agttctttca ggcgagctgc cagagcttga 374581 tctcccgctc gattatgccc gtccgcctgt gcaaagcttt aaaggagata cgatccgttt 374641 ccgtacggga agtgagacgg caaaggcggt agaaaaactg cttgccgaaa ccggaacgac 374701 cttgcacatg gtgctccatg ctgttttcca cgtcttttta agcaaaattt ccggacagcg 374761 ggatatcgtc atcggctccg ttactgccgg ccggacgaat gctgatgttc aggacatgcc 374821 gggaatgttc gtcaatacac ttgccctgag aatggaagcg aaagaacagc aaacatttgc 374881 ggagcttttg gagctagcaa agcagacgaa cctgtcagcc cttgagcatc aggagtatcc 374941 gtttgaagat ctggttaatc agcttgatct ccctcgggat atgagccgaa acccattgtt 375001 taatgtgatg gtgacgacag aaaaccctga taaagaacag cttacattgc aaaatctgag 375061 catttcacct tatgaggctc atcagggaac ttctaagttt gatctgacac tgggcggatt 375121 tactgatgaa aatggcattg gcttgcagct cgaatatgcg acagatctgt tcgcaaaaga 375181 aacagctgaa aaatggagcg aatacgttct gcggctacta aaggctgttg cggataaccc 375241 gaaccagccg ctttccagtc tgttactggt caccgagaca gaaaagcaag cgcttcttga 375301 ggcatggaag ggcaaagcgc tgcctgtgcc gacagacaaa acggttcatc agctattcga 375361 agagactgtc cagcgccaca aagaccgccc ggctgtcaca tacaacggcc aatcttggac 375421 gtacggcgag ctgaacgcga aggcaaaccg cctcgcccgg attctgatgg actgcggcat 375481 cagcccggat gaccgcgtcg gcgttctcac gaagccgtcg cttgaaatgt ccgccgcggt 375541 gctcggcgtc ttgaaagccg gagcggcgtt tgtgccgatt gatcctgact acccggatca 375601 gcggattgag tatattttac aggacagcgg cgcgaagctt ctcttgaaac aggaaggcat 375661 ttcagtgccg gacagctata cgggagatgt cattcttctc gacggaagcc gcacgattct 375721 aagcctgccg cttgatgaaa acgacgaggg aaatccagaa accgctgtaa ccgcggagaa 375781 cttggcgtac atgatttaca cgtctggaac gaccggacag ccgaagggtg tcatggtcga 375841 gcaccatgcg cttgtgaacc tgtgcttctg gcaccacgac gcgttcagca tgacagcgga 375901 ggaccgcagt gcgaagtacg cgggcttcgg gttcgacgct tccatttggg agatgttccc 375961 gacctggacg atcggcgctg aacttcacgt cattgatgaa gcgatccgcc tcgatatcgt 376021 ccgcctgaac gattattttg aaacgaacgg cgtaacgatc acgttcctgc cgacacagct 376081 tgcggaacag ttcatggagc ttgagaacac atcacttcgc gtcctcttga ccggaggaga 376141 caagctgaag cgggcagtga aaaagccgta cacactcgtc aacaactacg ggccgacaga 376201 aaatacggtc gttgccacaa gcgcagaaat ccatccggag gaaggctcgc tttccatcgg 376261 acgggccatt gccaatacga gagtatacat tctcggcgag ggcaatcagg tgcagccgga 376321 aggcgtagcc ggagagcttt gcgtggcggg gcgcggactg gcacgaggct atctgaatcg 376381 agaagacgaa accgcgaagc ggtttgtcgc tgatccgttt gtgccgggtg aacgcatgta 376441 ccgcaccggc gacttggtga agtgggtgaa cggcggcatc gaatacatcg gccggatcga 376501 ccagcaggtc aaggtccgcg gctaccggat cgagctctca gaaattgaag tccagctcgc 376561 ccagctttct gaggtgcagg atgcggcggt gacagctgtc aaagataaag gcggcaatac 376621 agcgatcgcg gcgtatgtca caccggaaac agctgacata gaagcactaa aatcaacact 376681 aaaggaaacc ctgccggatt acatgatccc ggcgttctgg gtgacgctga acgagcttcc 376741 ggttacggca aacggcaaag tcgaccgcaa agccttgcct gagccggaca tcgaagcggg 376801 aagcggagaa tacaaagcgc cgacgaccga catggaagag ctgcttgccg gcatctggca 376861 ggacgtgctt ggaatgtctg aagtcggtgt caccgacaat ttcttctcgc ttggcggaga 376921 ttccatcaaa ggaattcaaa tggcgagccg cttgaatcag cacggctgga agctggaaat 376981 gaaagatctc ttccagcatc cgacgatcga agagctcacc cagtacgtag agcgtgccga 377041 aggcaaacag gcagaccaag gcccggtgga gggcgaagtc atcctgacgc cgatccagcg 377101 ctggttcttt gaaaagaact tcacgaacaa gcaccactgg aaccaatcgg tgatgcttca 377161 cgccaaaaag ggctttgatc ctgaacgggt ggagaaaaca ttgcaggcgc tgatcgagca 377221 tcatgacgcg ctccgcatgg tctaccgcga ggaaaacggg gacatcgttc aggtgtataa 377281 accgatcggt gagagcaagg tcagcttcga aatcgtggat ctgtacggct ccgatgaaga 377341 gatgctgaga agccagatta agcttctcgc gaacaagctg caaagcagtc tcgatctgcg 377401 aaacgggccg cttttaaagg cggagcaata tcgcacagaa gctggggatc acctgctcat 377461 tgctgtacac catctcgtgg tcgacggtgt gtcatggcgg attttgcttg aagactttgc 377521 ttcaggctac atgcaggctg agaaagaaga gagccttgtc ttcccgcaaa aaacaaactc 377581 cttcaaggat tgggcggaag aactggcggc attcagccaa tcagcgcatc ttttacagca 377641 ggctgaatac tggtcgcaaa ttgccgctga acaggtttct cctttaccta aggattgtga 377701 aacagagcag cggatcgtca aggatacatc atctgtccta tgtgaattaa cggcagaaga 377761 cactaagcat cttttaacag atgttcatca gccatatgga actgaaatca acgatattct 377821 tctcagcgcg ctcggtttga caatgaaaga atggacaaag ggggccaaaa ttggcattaa 377881 ccttgaggga cacggccggg aggacattat cccgaatgtg aatatctcca gaacggtcgg 377941 ctggtttacg gcacaatacc ctgttgtgct cgacatatct gacgcagatg cctcagctgt 378001 gatcaaaaca gtcaaagaaa acctgcgccg cattccggac aaaggtgttg gctacggcat 378061 tcttcgttat ttcacagaaa cagcggaaac aaagggcttc acaccggaga tcagcttcaa 378121 ctatttgggc caattcgaca gtgaagtcaa aaccgatttc tttgaaccgt ccgctttcga 378181 tatggggcgc caagtaagcg gagaatcaga ggcgctgtac gcattaagct tcagcggcat 378241 gatcagaaac ggccggtttg tgctttcctg ctcctacaat gagaaggagt ttgaaagagc 378301 tacagtcgag gagcaaatgg aacggtttaa agaaaacctc ctgatgctaa tccgccattg 378361 cacggaaaaa gaagacaagg aattcacacc aagcgacttc agcgccgaag accttgaaat 378421 ggacgagatg ggagatatct ttgacatgct tgaggagaat ttaaaataaa acgcaaggga 378481 attacagaag gcgggagcga aacatatgag tcaatttagc aaggatcagg ttcaagatat 378541 gtattaccta tcgccgatgc aggaagggat gctttttcat gccatcctga atcccggcca 378601 aagcttttac cttgaacaaa tcacgatgaa agtaaaaggc agcttgaata tcaaatgtct 378661 tgaagaaagc atgaatgtga tcatggaccg gtacgatgta tttcgtaccg tgttcattca 378721 cgaaaaagta aaaaggcctg tccaagtcgt attgaaaaaa cggcagttcc atatagaaga 378781 aatcgatctg acacacttaa cgggcagcga gcaaacagcc aaaatcaatg agtacaaaga 378841 acaggataag atcaggggtt ttgatttgac gcgggatatt ccgatgcggg cagccatttt 378901 caagaaagct gaagaaagct ttgaatgggt gtggagctac caccacatta ttttggacgg 378961 atggtgcttc ggcatcgtcg tacaggatct atttaaggta tacaatgctc tgcgcgaaca 379021 aaagccgtac agcctgccgc ccgtcaaacc gtataaagac tacatcaagt ggcttgaaaa 379081 gcaggataaa caagcatcac tgcgttactg gcgcgaatat ttagagggct ttgaaggaca 379141 aacgacgttt gcggagcaaa gaaagaaaca aaaggacggc tatgagccga aagagctgct 379201 cttttcactg tcggaggcgg aaacaaaggc ctttaccgag cttgcaaaat cgcagcatac 379261 cactttgagt acggcgctgc aggcagtctg gagcgtattg atcagccgct atcagcagtc 379321 tggcgatttg gccttcggta cagttgtttc agggcgtccc gcggaaatca aaggcgttga 379381 acatatggtc gggctgttta tcaacgttgt cccgagacgt gtgaagctgt ctgagggtat 379441 cacatttaac ggcttgctca agcggctgca ggagcaatcg ctgcagtccg agccgcatca 379501 atatgtgccg ctttatgaca tccaaagcca ggccgatcag ccgaaactga ttgaccacat 379561 cattgttttt gagaactatc cgcttcagga tgcgaaaaat gaagaaagca gtgaaaacgg 379621 ctttgatatg gtggatgttc atgtttttga gaagtcgaat tatgatctca acctgatggc 379681 ttccccggga gatgagatgc tgattaagct tgcctataat gagaatgtgt ttgatgaggc 379741 gtttatcctg cgcttgaaat ctcagcttct tacagcaatt cagcagctca tccagaatcc 379801 tgatcagcct gtcagcacga tcaacctcgt tgacgacagg gagagagaat ttttgctaac 379861 cggcttaaac ccgccggctc aagctcatga aacaaagcct ctgacgtatt ggttcaagga 379921 agcagtgaac gccaatccgg atgcaccggc gcttacgtat tccggccaga ccctgtctta 379981 tcgcgaatta gatgaggaag cgaaccgcat tgcacgccgg ctgcaaaaac acggtgcggg 380041 caaaggctct gttgtagcgc tgtacacgaa gcgctcactt gaactggtga tcggcattct 380101 cggtgtatta aaggcgggag cagcctatct gccggttgat ccgaagctgc cagaggaccg 380161 aatctcgtat atgctggctg acagtgcggc agcctgtctt ctgacgcatc aggagatgaa 380221 agaacaagcg gctgagctgc cgtatacagg cacaacgctc ttcattgatg atcaaacacg 380281 gtttgaagaa caggcaagcg atcctgcaac cgcgattgat cctaatgatc cggcatatat 380341 catgtacacg tccggcacaa ccggaaagcc aaagggcaat atcaccactc atgccaatat 380401 tcaaggattg gtcaagcatg tagactacat ggcattttct gatcaggata cgttcttgtc 380461 tgtttcgaat tacgcctttg atgcatttac ctttgatttc tatgcttcta tgctgaatgc 380521 ggcacggctc attatcgcag atgaacatac gctgcttgat acagaacggc tcacagatct 380581 gatcctgcaa gagaatgtca atgtcatgtt tgcgacaacc gcactattta atcttctcac 380641 agatgcggga gaggattgga tgaaggggct tcgctgtata ttattcggcg gagagcgcgc 380701 gtcagtgcct catgtcagaa aagcgctgcg gatcatgggg ccgggcaagc tgattaactg 380761 ctacgggccg actgagggaa cagtgtttgc gacagctcac gtcgtgcatg atctgccgga 380821 ttccatctcc tcattgccga tcggaaagcc gatcagcaat gccagtgttt atattctgaa 380881 tgagcaaagc cagctccagc cattcggggc ggtcggtgaa ctgtgcatca gcggaatggg 380941 cgtgtcaaaa gggtatgtaa atcgtgctga cctcacgaag gaaaagttta tcgagaaccc 381001 gttcaagccg ggagaaacgc tttaccgtac aggggattta gcgcgctggc tgccggatgg 381061 aacgattgaa tacgccggcc gtattgacga ccaggtcaaa atacgcggac accggattga 381121 gcttgaagaa atcgaaaagc agctgcagga atacccaggt gtgaaagatg cggtcgttgt 381181 ggcggaccgc catgagtctg gcgatgcatc aatcaatgcc taccttgtga accgaacgca 381241 gctttcagct gaagacgtga aggcgcacct gaaaaaacag cttcctgctt acatggtgcc 381301 gcaaaccttt accttcttgg atgagcttcc tttaacgacg aacgggaaag tcaataaacg 381361 gctgctccca aaacctgatc aggatcagct ggcggaagaa tggattggac cgcggaacga 381421 gatggaagaa acaatcgcac aaatatggtc tgaggttctc ggcagaaagc aaattggcat 381481 tcatgacgat ttctttgcgc tcggagggca ttccttgaag gccatgaccg ccgcgtcccg 381541 catcaagaaa gagctcggga ttgatcttcc agtgaagctt ttgtttgaag cgccgacgat 381601 cgccggcatt tcagcgtatt tgaaaaacgg gggctctgat ggcttgcagg atgtaacgat 381661 aatgaatcag gatcaggagc agatcatttt cgcatttccg ccggttctgg gctatggcct 381721 tatgtaccaa aatctgtcca gccgcttgcc gtcatacaag ctatgcgcct ttgattttat 381781 tgaggaggaa gaccggcttg accgctatgc ggatttgatc cagaagctgc agccggaagg 381841 gcctttaaca ttgtttggat attcagcggg atgcagcctg gcgtttgaag ctgcgaaaaa 381901 gcttgaggaa caaggccgta ttgttcagcg gatcatcatg gtggattcct ataaaaaaca 381961 aggtgtcagt gatctggacg gacgcacggt tgaaagtgat gtcgaagcgt tgatgaatgt 382021 caatcgggac aatgaagcgc tcaacagcga agccgtcaaa cacggcctca agcaaaaaac 382081 acatgccttt tactcatact acgtcaacct gatcagcaca ggccaggtga aagcagatat 382141 tgatctgttg acttccggcg ctgattttga catgccggaa tggcttgcat catgggaaga 382201 agctacaaca ggtgtttacc gtgtgaaaag aggcttcgga acacacgcag aaatgctgca 382261 gggcgaaacg ctagatagga atgcggagat tttgctcgaa tttcttaata cacaaaccgt 382321 aacggtttca taaatgaagt gatgaaagga ggagacagcc aatgagccaa ctcttcaaat 382381 catttgatgc gtcggaaaaa acacagctca tctgttttcc gtttgccggc ggctattcgg 382441 cgtcgtttcg ccctctccat gcttttttgc agggggagtg cgagatgctc gctgccgagc 382501 cgccgggaca cggcacgaat caaacgtcag ccattgagga tctcgaagag ctgacggatt 382561 tgtacaagca agaactgaac cttcgccctg atcggccgtt tgtgctgttc ggacacagta 382621 tgggcggaat gatcaccttc aggctggcgc aaaagcttga gcgtgaaggc atctttccgc 382681 aggcggttat catttctgca atccagccgc ctcatattca gcggaagaaa gtgtcccacc 382741 tgcctgatga tcagtttctc gatcatatta tccaattagg cggaatgccc gcagagcttg 382801 ttgaaaataa ggaggtcatg tcctttttcc tgccttcttt ccgatcagat taccgggctc 382861 ttgaacaatt tgagctttac gatctggccc agatccagtc gcctgttcat gtctttaacg 382921 ggcttgatga taaaaaatgc atacgagatg cggaagggtg gaagaagtgg gcaaaagaca 382981 tcacattcca tcaatttgac ggcgggcaca tgttcctgct gtcacaaacg gaagaagtcg 383041 cagaacggat ttttgcgatc ttgaatcagc atccgatcat tcaaccgtga tcaaaagcgg 383101 acagcttcgg ctgttccgct ttttttgtgt tgaatgccaa tttctgcatg gtataatagt 383161 cgaaatactc aaataaaggc aggtcgaaac atgcgcacgt ctcccaggat gaaatggttt 383221 gtattgctgt ttacgtttgt tttcgccatc ggaatgaact cattcagaaa ttcctttcaa 383281 ttttttatgc tgccaatggc agacgccttc catgccgaca ggtcgctgat ttcggtttct 383341 gtcagcattt ttatgatcac aaccggcatc gtccagtttt ttgtcggttt ttttatcgac 383401 cgtttcagtg tcagaaaaat tatggcgctg ggagctgttt gcatcagcgc aagctttttg 383461 gtgcttcctt attcaccgaa tgttcatgtg ttttccgcca tttacggtgt gcttggcgga 383521 atcgggtatt cctgcgcggt cggcgtgacg acccagtatt tcatcagctg ttggtttgac 383581 acacacaaag gtctggcgct tgctattttg accaatgcca actctgcggg cctgctgctt 383641 ctctcgccca tttgggctgc ggctccgtat catgccggct ggcagagcac ctataccatt 383701 ttgggaatcg tcatggcggc tgttctgctg ccgctcctcg tctttgggat gaagcacccg 383761 ccacatgcgc aagcggaaac tgtgaaaaaa tcttatgatt ggcgagggtt ttggaacgtg 383821 atgaagcaat cccgcctcat tcatatcctg tacttcggcg tgtttacttg cggatttaca 383881 atgggaatta ttgatgctca cctcgtcccg atactgaagg atgcgcatgt ctctcatgtc 383941 aacggaatga tggccgcgtt cggggcattt atcatcattg gcggattatt ggcgggctgg 384001 ctgtcagatc tcctcggcag cagaagcgtc atgctatcca tcttattttt cattcggctg 384061 ctcagcctca tttgcctgct cattcccatt ctcggaattc atcacagcga cctttggtac 384121 ttcgggttta tcctgttatt cgggctcagt tacacaggcg tgatcccgct gaccgcggcg 384181 tcaatttcgg aaagctatca aacaggattg atcggatcgc tgttaggcat caatttcttt 384241 atccatcagg ttgccggagc tctcagcgtg tatgcgggcg gtttgttttt tgacatgact 384301 catggttatt tactgattgt cgctgtgtgc atcgtgtttg tgggtttatc ggctgtaata 384361 gagctggtgc cgtttttaga taaacagaag gcaaaagaaa cccaccattc aatataaaag 384421 gatcagcact gtcaatgctg atccttttta aatttgagtt tttttgtttc ggtattttta 384481 aggataatct ccttgaatct gttcatctcc tcttcggagt gaaaaaaatg tttggggatc 384541 gcaatatatt ggccacttga tgtattgacc ctgaagatat ttttatattc gaaaacagct 384601 gtaatttcat cccaattgaa aatgaggtca tattttttag aacatatacg aattccttct 384661 tggttcagag tatatgttct tttggatttc atccgttcgt tcttcttgta tgctctggaa 384721 aacttcacat atagaagaag gaggagcagc agtgtaaaca gaacggacat cacgataatc 384781 aacatactgt tcataaacaa gttaagcgcg tcacttccat aaacgatacg gggccatccg 384841 ttaatgaagt taactgcagc aaatatggcg caaaacaata gaaagtaaaa gcatgatatt 384901 tttgcgattt gataaaaaaa gatttctctt acatccttaa aagtgatttc tcctggaaga 384961 ttgatacttt cactagcata ttgaatcata cggtaaacct acacctctaa ccatgttttt 385021 ccttttagtc tagcataatt tctcattttt ttgcaggcat accagggcgc tttgtttttt 385081 tctccagatt gatattgctc cccaccacgc caatcataat acaaacagcc ccggcaagat 385141 gataccaggc caggctttcg ttgagaatca caaatcctgc aatcatcgtc acaatggtag 385201 atacatgatt aaaagcgctc attttaaacg cctcaattcg cgacagcgta tagttagaca 385261 gaaatgaagt gacaagtgaa gacagcacgc ccaaatacac aatggcgaga acgaagccgg 385321 gctcccggaa cggcagaaaa taagtgccga ctgttcccgc cgctccgtga cgcacaaggg 385381 cgatggcgtt gaagacgaca aagccgatgg ctgacatgat gtaggtgagc tcggtcagct 385441 tgaaccgctg cgtcattttt ctggcagcag tattgtacat cgctgaagac aaagcggaca 385501 ataggatcag caaagaccct tttaagctgg ctgattccac gtcaacgcct ttcatcacaa 385561 aaataaacat gacgccggca acggataaaa ccgtgaaccc cttttgcgtc cacgttgggc 385621 gttcctttaa aacataagcg gcaaagacca tcgtgaaaat cggaatggct gcctgaataa 385681 ttcccgcttc agaggaggac gagtacacaa ggccgaatgc ctgaaagctg aaaaataacg 385741 cgggatacag cagggcgagc ggcaaaatgt caatgacgtc ctttacgcgg attgatagct 385801 ttacccagcc gaataagatc ggtacagtgg ccgcagcaaa cgcaatggtg aaccgatgcg 385861 ccaaaatatc aaacggctct gctgtttgca gtgcgatttt tacgaataga aaggataaac 385921 cgataatgaa cgaatataaa atagccgcta tataagcggg ggtttgctga tgtttaacca 385981 taatgggaag ggctccttta cctgaattgc agcgccggtc gctcccttta ttgtatggcc 386041 gcggtcagaa cggtacaatg agaaaaacaa tgaactgtac cggtacaaaa cagggggaga 386101 aggcatggag aaatatatga gtctattaac gaggatagag gagatgatgc aaagcacctc 386161 atatcaagaa ggagacaggc ttccatctat ccgtcagctg tccgcccgct accaagtcag 386221 caaaagcaca gtgatccgcg cgctgcagga gctggaaaag cgccacctta tctattctgt 386281 tccgaaaagc ggctattata ttgtgaaaaa gtcagggaaa tcaaaaagcg ggcagcctgg 386341 ccccatcgac tttgccacat ctgcgccgga tcccgatgtg tttccgtatc ttgattttca 386401 gcactgcatc aacaaagcga ttgatacata caaaaacgat ttgtttattt atgggacgcc 386461 aaaggggctt ccatcactca tccgcgtact ccgaaagctc ttggccactc aacaggtatt 386521 tgcggatgaa cggcatattt tcattacatc aggtgtccag caggcgttat ccttgctttg 386581 tgccatgccg ttcccaaatg ggaaagagaa gatcgccatt gaacagccgg gctaccattt 386641 gatggtcgaa cagcttgaga cacttgggat tcccgccatc ggggtgaaac gaacggaaga 386701 agggcttgat atagccaagg ttgagcggtt atttcaaaca gaatcgatta aattttttta 386761 tacgatgccg cgcttccata acccgcttgg gtgctcattg tcagagcgtg ataaacagga 386821 gcttgtgaga ctggcagaag cgtatgatgt ctatctcgtt gaggatgatt acctcggtga 386881 tctggaggaa aataaaaagg cagatccgct gtacgcatat gatctgtcct cacatgtcat 386941 ctatttgaaa agcttctcga aaatgatgtt ccccggcctc cgcgtggggg cggctgtttt 387001 gcccgaagcg ctgactgaca cgttctatgc gtacaaaaag ctgaacgaca tcgactgttc 387061 gatgatttct caagcggcat tggagattta cctgaaaagc ggtatgtacg gcaggcataa 387121 ggagaaaatc agagattctt ataaagagcg gtcgctgagg ctacatcaag ccattcgaac 387181 tcacaggcag ctgggaagcg gacgctttac gttctccagc gggcaggcac cctgtatgca 387241 cacccatctg gtgcttcctc aggatctgcc cgcctcaaga gtgattcata gactggaaaa 387301 acaaggggtt ctccttgagg cgatagaccg tcattattta tcagattatc cgaaagaaaa 387361 tctattaaaa atcaatattt ccaatgtgaa aacggaagat attgagcgcg gtgtcaagct 387421 gttgatgagc catttataaa agctcttcgt acgagaccat tgtgatatcc tcggggaaat 387481 cagggtgtac ggcgcataca gccattttgt agccgggatc gacctcatac gttttgatat 387541 agcatgggga atggctgtcc ggaagctcaa tggatacttg tccgtcctgg tgcaggcgca 387601 ctgaaaagga atcaagcgga agcgataagc ctttgccttc cttgtttgat aaagctttct 387661 ttcattgacc atagatgata aaaatagtct gtctgctcgt ccttgtcttt tgctaaaagg 387721 tcgctgtact ctgtttttga aaagaagcgc ttggcgatct caaggctgat cggtttcgtt 387781 ttttcgatat ctatgccgat cggctgtgaa tcaaacgcgc aaatgaccca gcgtccggag 387841 tgagaaatgt tgaaatgagc gtcgggaaga tcagggatgc acggcttccc gtattcctgc 387901 gtgctaaagc ggatatcgga tttgtccaac tgatactgcc tgcttatgac tgagcgaacg 387961 agcacatctc ccagcagggt gcggtgagca tcttctttat gataaaatct ccggcatttc 388021 tcccgttttt caggtgatat gaaagacatg aaccgttcat tttcttcctg tgaaagcggg 388081 cggtccatat aaattccgta aatcttcatt ctagatcctc cgtctgcaaa agattgtcaa 388141 aaccatccta tcatacttcc acaagactca tatagaggag aaaataaaaa aacaaagcca 388201 aggcggcttt gttttagtgt acaggcggag atgctttcac tgcggctgtc cgccttgcca 388261 cagcataatt cagcaactgg attgactggg gcaatgaaaa acgcaaaata agtccggtga 388321 ggatggcggt caaaatggtg ccaaaaccga tcggtccgcc catgccccat gccgcaaaca 388381 aaatggttaa ttccatgccg ttccgcaccc attgcacatt ccagccggtt ttttctgtaa 388441 tcagcatcat cagtgaatca cgcggccccg cgccaaggcc tgctgataca taaacaccga 388501 cgccgtaacc aatcagcacc acgcctagag agaagacgat gatcgagcct gtgtaggtcg 388561 agagggcagg cagaatgaaa ttgaaaaaat ctataaatac accaatgagc accatattca 388621 ggagggcacc aattttcggc caagctctcg taaacaatga cgtgaatccg acgatgagcg 388681 ctccaataat gatggaccac tggccgacgg taagcccgaa gtgctgaaac aggctgtaat 388741 gaaatgcatc ccacggacta atgccgagtg cttttccttc tatcgtcagg gatacaccaa 388801 aagccaaaat gatcaaaccg gcaaaataaa atgtccagcg cagaacaagt tcttgcttca 388861 cgtgaggtcc cttctttcgt aaaaatcagt cgattgtcat tgtagcacat ctgacagaag 388921 ggcggaatag gcgaaagggg ctcaacaaaa aaacagggcc gccggaggcg ccctgtttca 388981 gcgtgttggc aaacccttgc attcgttgtc aggcctgtgc ttcggtgctc acgaatttaa 389041 cattagctgt gctccaatgc tcgcccttcc tagacttcaa aggttttcaa tcacgctgaa 389101 aatcacaaaa tcctaaaacg aatatcgttt taggattttg tcaataatct gaaacagggc 389161 gctgacgctc tgtttttctt attacagcgg gttcaaaatc cggtttaaga accgctgtgt 389221 ccgttcttct tttggtgcgg agaaaatttg ctccggcggt ccctgctcca cgataacgcc 389281 gccgtcgatg aagatgactt catccgcaac ctcctgcgcg aacttgattt cgtgggtcac 389341 gacgaccatg gtccagcctt cattggccaa gtccttgata accttcagca cctctccgac 389401 aagctcggga tcaagcgctg aggtcggttc gtcaaacagc atgagctcag gctgtatcgc 389461 cagtgcgcgg gcgatgccga cgcgctgctg ctggccgccg gaaagctgga acggatataa 389521 atccattttg tccttcaatc cgactttatc aagaagctga atcgcttctt ttctgacttc 389581 ctctttgttc cgtttttgca cctgaacagg gccctccatc acgttttcga gggctgtgcg 389641 gtgcgggaac aggtgatacg cctgaaacac cattccggat tttcggcgaa gctttaggat 389701 atccgcctgt ttcacctttt tggagaaatc gatggagaaa tcatcaaatg caagctctcc 389761 gcgattcggg atctccagag cgttcaggca gcggagcagc gtcgttttcc ctgaacctga 389821 aggcccaagt atggcgatga cttttccttt ttcaatcttc atatctatct tttttaaaat 389881 ttcattttca ccgaatgatt tgtttaatcc tttaacggta agcatactcg gaacctcctt 389941 atttggccac gtagcggtca agacgccgtt cgatgacatg ctggacgagt gagagcagga 390001 agcagataat ccaataaata aaggctgctt caatatagat cactaaaatt tgatcaagat 390061 tccgcgcgcc gatttcctgg gcttttctga acagctcagc gaccagaatt tgagaggcga 390121 gggatgtatc tttaatcagg ctgataaagg tattggataa tggcgggatc gacacacgaa 390181 acgcctgcgg caaaatgacg cggaacagcg ttttttgatg tgtcatgcca attgtgtagc 390241 cggcttccca ttgccctttc ggcacggata aaatagatgc ccgaatgatt tcagatgcat 390301 aggcgccgac gtttaatgaa aaggcgataa ctgcgcttgg aaatggatct aatgtgacgt 390361 taaaggccgg gaacagatag aaaatgatga acaattgaac gagaagagga gtgccgcgta 390421 ttgcggatac gtatacgctg aacacccatc tcaaaggtct cactttcgac attctggcaa 390481 gcgccgtaat cagcgccagg atcattccga atataaagga aagaatcgta aggggaatcg 390541 tatagtagat tccccctgaa agtatcggcc agaatgactg ctgcaccaga tcccacggga 390601 tcgccgtgcc aagcgtcaat gccggcagat tatttagaaa catcttcgcc gaaccatttt 390661 ttagaaattt tagaaagagt cccgtcctct ttcatttctt ttaatgcttt gttgacttga 390721 tcaacaacct cgccgcttcc tttacggaac gtgaaatatg ttgactgagg ctcacctgtt 390781 tcaaacgcga ttttcacgtt tttattgcca gatgttttta agtagttcaa tacggcaagc 390841 ttatcgttgt atgtcatatc gacgcggcct tgctggatca tttgaagggc ctgcgccatg 390901 ccttcaacgc cttctacttt agcgccggca tttgtagcta atttgttgta gttgcttgtc 390961 agtgattgag ctgacgtttt tccttttaca tctgcttcag acttaatatc gttgttgtct 391021 tttttcgtta cgacaacggc tcttgatgtt gtgtatttat ctgagaaatc atatttgtct 391081 tcacgatctg tttttccgac ttggttggca acaacgtcaa accgtttgga attcaggccg 391141 gcaaacatac tgtcccattg tgtttcctta aagtcgactt taagcccgag gcgttttgcg 391201 acttctgtga taacttcgac atcatagcca gtcagtttat cagtgtcttt gtcgtggtaa 391261 gtgaacggct catatgttcc ttccgttccg actgtgagca cacctttttt cttaattgaa 391321 gcccaaagat cgccatcttt ggcattatct tttgactgat tgtcatttcc tgctccgcaa 391381 gctgcaagag ctgcaatact tacgaccatg aataaagcca ataatgcttt tttcatctta 391441 ttccccactt ttctggttga ttttattgaa ataaaaaatt agcttacaaa tctaaaggat 391501 aacttttttt tagtatgagt caagtatttg gttttcataa gacaaaatct tttaaaataa 391561 atccaaaaat tgctgtgccg gtttaggcaa ataactgtcc gttctccaca tgacagccgg 391621 tgtcataatg aagggattat tttcgatatg gacggtgtga acgtgatttc tcatatgaac 391681 gggaatcatt gtgacaggca aaatagacgc gccgaatccg gatgacacga ggctgagcaa 391741 agttgcagag tcgtggcatt cacaaacaat gcgcggctcc aggttcaaac gatgaaattc 391801 attcatgacc tgattataga cgccttttcc gttgacaggc cgcagcagga tcagcggaaa 391861 tgaaggaatg tccaccatct taatggtgtc tccgcacgga tatccggctt catctgaaag 391921 cacgagcaca catggaatgt catcaagctg cttgaattgt actgtgtcac ttttgatcag 391981 tgttgtcgtg accgccgcat cgatttgccg gctttccagc agttccaaca gtgtcgcggg 392041 ttcattttcc caaatattaa aggtgagatg ggggtatctc tctttgatct gtgttacttt 392101 ttcaagcatc agagccgcgc aataaatcgt tgatcccacg gcaagtgtac cggctacttc 392161 ctccttcagc tcctgtacct caatgactgc atcttcaaac ctatgcagaa tctcttttgc 392221 tctttttaga aaaacagctc cttcatatgt aagagtcatt tgttttttct tgttacggtc 392281 aaacagaaca acaccaagtt cgtcctccag ctgtttgagc tgcctgctta aaggcggctg 392341 cgccatgtga agctttttgg ctgcggacgt aattttctgt tcttgggcaa tggtaatgaa 392401 gtatcgaagc tggcgaatat ccaaaagaaa gcgcctcctt atcatacctt ttaggtatta 392461 attatagatt taatagatat ttttcatatg gatatatcag gagtatgatt gaaatgaaag 392521 cagaattcaa gcgtaaagga gggggcaaag tgaaactcgt tgtcggaatg acaggggcaa 392581 caggggccat tttcggggtc aggctgctgc agtggctgaa ggccgccgga gtggaaaccc 392641 atctcgttgt gtctccttgg gcaaacgtca cgatcaaaca cgaaacaggc tatacgttac 392701 aagaagtaga acaactggcc acatacactt actcacataa ggatcaggcg gcagccattt 392761 caagcgggtc gtttgatacc gatggaatga ttgttgcgcc gtgcagcatg aaatctctcg 392821 caagcattcg cacaggaatg gcggataatc tgctgacacg tgcggcggat gtcatgctca 392881 aggagagaaa aaaactcgtc ctcttaacga gagagacgcc tttgaaccaa attcatctcg 392941 aaaatatgct agcgcttacg aaaatgggca ccatcattct tcctccgatg ccggcatttt 393001 ataatcggcc gagaagctta gaggaaatgg ttgaccatat tgtttttaga acgttggacc 393061 aattcggcat tcggcttcct gaagcgaagc gctggaatgg gattgaaaaa caaaaaggag 393121 gagcttgatc atggcttatc aagatttcag agaatttctc gctgcccttg aaaaagaagg 393181 acagctgctt acagtgaatg aagaggtaaa gccggaaccg gatttagggg cctccgcacg 393241 ggcagccagc aatcttggcg ataaaagccc tgcgctctta tttaacaaca tttacggcta 393301 tcataacgcg cgaattgcga tgaatgtcat cggctcttgg ccaaaccatg ccatgatgct 393361 gggcatgccg aaagacacac cggtaaaaga acagtttttt gaattcgcaa agcgttatga 393421 ccagtttccg atgccggtca aacgtgagga aacagcgcca tttcatgaaa atgaaatcac 393481 agaagatatc aatttgttcg atatactgcc tcttttcaga attaaccagg gtgatggagg 393541 ctactattta gacaaagcat gtgtcatttc ccgtgatctt gaggaccctg acaacttcgg 393601 caaacaaaat gtcggcattt acagaatgca agtcaaagga aaagaccgcc ttggcattca 393661 gcctgtcccg cagcacgata ttgcaatcca tctgcgccaa gctgaagaac gcggcatcaa 393721 ccttccggtc actattgcgc tcggctgtga gccggtcatt acaacggcgg catcgactcc 393781 gcttctctat gatcaatcag aatacgaaat ggcaggtgcg attcaaggcg aaccatatcg 393841 catcgtcaaa tcaaagctgt ctgatcttga tgttccgtgg ggcgctgaag tggtgcttga 393901 aggtgagatt attgccggag agcgcgaata tgaagggccg ttcggtgaat tcacaggcca 393961 ttattccggc ggacgcagca tgccgattat caaaattaaa cgcgtctatc acagaaacaa 394021 tccgatcttt gaacatttat acttaggcat gccttggaca gaatgcgatt acatgatcgg 394081 cattaacaca tgcgtgccgc tttatcagca gttaaaagaa gcgtatccga acgaaattgt 394141 ggcagtgaac gccatgtaca cacacggttt aatcgcgatt gtttccacaa aaacccgcta 394201 tggcggattt gcgaaagcgg tcggcatgcg cgcactcaca acgccgcacg gactcggcta 394261 ctgcaaaatg gtcatagtcg ttgatgagga tgtcgatcca ttcaaccttc cgcaggtcat 394321 gtgggcgctt tcgaccaaaa tgcatccgaa acatgatgcg gtcatcattc cggacttatc 394381 tgtcctgccg cttgatccgg gatccaatcc atcaggaatc actcacaaaa tgattctcga 394441 cgccactaca ccggttgcgc cggaaacaag aggccattat tcacagccgc ttgattctcc 394501 gctaacaacg aaagaatggg aacaaaaact aatggactta atgaataaat aaggaaagga 394561 tgttcgaaat gcatacatgt cctcgatgcg actcaaaaaa gggagaagtc atgagcaaat 394621 cgcctgtaga aggcgcatgg gaagtttatc agtgccaaac atgctttttt acatggagat 394681 cctgtgaacc ggaaagcatt acaaatcccg aaaaatacaa tccagcgttt aaaattgatc 394741 caaaggaaac agaaacagca attgaagttc cggcggtgcc ggaacgaaag gcttgatccg 394801 cgtgaactgt atgtcagacc gtctctttga gctgcttgac gggagctgcc tgaatgagaa 394861 gcagcatgag gccttcgttc tgcaaacagt atcagaggat ggctggccgc atgccgctat 394921 gatcagtgca ggtgaaatca tcgcgctgag ccgaactgat atccgaatcg ctctgtggaa 394981 aaacacaatg acttcggcca acatccttcg cacaggaaaa gcacagttca cggcgtggtg 395041 gaagggagcg gcctattatg taaagcttga atgcgcgcct ttaccgcctt tgaaagatgc 395101 cgaatatgaa agagaccgtt tttcctgccg catcgtttca gtgaaagagg acgttgcgaa 395161 atacgctgat ttgacttcag gtgtccgtat acagcttcac agccctgaag aggtgctgag 395221 cagatggaaa aagaccctgg aagatttaaa acggtaatat cgatagcctg acgccatgcg 395281 tcaggctttt tttatataat gaaaacaaaa gggggcgtga gaaatggaac gtgcggggat 395341 ctgtcactcg gacggctttg atttagctta tcgaattgag ggcgagggcg cacccatcct 395401 tgtgatcggg agtgcggttt actatccgcg ccttttttcc tcagatatca aacagaaata 395461 tcaatgggtc tttgtcgacc ataggggatt tgctaagcct aagcgggagc ttcgtgcgga 395521 ggattcgagg cttgatgctg tcttggctga tatcgaaagg atgagaacat ttcttcagct 395581 tgaggatgtt actatcctgg gacattccgg gcacgctttt atggctttag agtatgccag 395641 gacatatccc aaacaagttc ggaaggtggc gctctttaat actgcgcctg ataacagtga 395701 agaaagacag cgaaaaagcg aatcattttt catggaaaca gccagtcttg agagaaagaa 395761 acgctttgaa aaagacatcg agaatttgcc gcaggacatc gacaaagatc ctgaaaggcg 395821 ctttgtgcac atgtgtattc gcgctgaagc gaaaagcttt tatcaagagc ggccgcatgc 395881 tgctgcctta tgggacggtg tattcacgaa tatgccgatc attgatgaat tatggggcaa 395941 tacatttgcc cggattgatc ttcttcagcg gttagctgat gttcgtatgc cggtgtatat 396001 cggattaggg agatatgatt atttggttgc gcccgtttcg ctatgggatg ctgttgacgg 396061 tttatatccc catgttgata aggttatttt tgaaaagagc ggccatcagc cgatgctgga 396121 agaaccggaa gcctttgatc aaagcttcag gaaatggctt gatcaataaa aaacagcccg 396181 cagatcaaca tccgcgggct gtttctgatt ataagacccc tttcatcgcg cgtttgatca 396241 ccggcgagag cagcaggaga atgccgccaa gaacgataga aatcaaaccg atggtgccga 396301 agtacattgt ttcaggaatt ttatcaaaca atccggctac ttgggcattg atcgcttggg 396361 ctgctgcgtt cgtcagaaac cacatactca ttgtctgtgc agagaaggca gctggtgcca 396421 gtttcgttgt cacggataaa ccgactggag acaggcacag ctctccaagc acgacaagca 396481 ggaagctgag aacgagccaa agcgggctta cgagtgcttc ttttccttgc atagcaggga 396541 ataccataat gataaatgac aatccggcta aaataattcc gattgagaat ttaactggtg 396601 tagacggctg acgtttgcca agcttcatcc agagccatgc gaatattggc gcaaaaatga 396661 caacaaacaa tggatttaat gattggaacc atgatgactg aagttcgaat ccgcccaatg 396721 aaagtcttat gcgttcatca gcgtataccg caagaatggt cgctccctgt tcctgaatgg 396781 cccagaacat gacagcaccg ataaacaaag gaacgtaagc ggcaagacgg gatttttctg 396841 ttttgtccgc ttttttgctt gtaaacatga tgatgaaata aatcacagga atcaaaatac 396901 cgagaatact tacaaggtca atgaaacgtt tgatcgtcag cacgcctgtt tgtacagaga 396961 taatcactgc gatcgccaca atgataacac cgattccggt gccaattgca gattttttag 397021 acagcggatt cggcacattg gaacctgcaa gcccgaggtt tttctttctt gtcaaagcaa 397081 atacgataag tccgagaagc attccgaccg cggcagctcc gaatccgaga tgatagttgt 397141 acttctgtcc gagtgttccg acaattaacg gcgcgagtaa accaccgagg ttaatcccca 397201 tgtagaaaat actgaaacct gagtcgcggc gcgggtcttc tttcgtgtaa agatccccaa 397261 ctacgcttga aacgtttggt tttaataagc ctgttccgac aatgataagc accatactga 397321 tatagaatgc tatcgaactg cccggatagg cgagtgcaat gtggccgaac ataatgaata 397381 tgccgccgta aaacacggtg tttgcggtac cgaatacccg gtcagcgagc catccgccaa 397441 taatggtgga catgtatacg agtgatccgt aaatcgacat aatggcaacc gcagtgccct 397501 tgtcaaagcc gagccctccg tttaccgtct ctgtatacaa atagtaaagt aagattgctc 397561 tcattccata gtaagagaaa cgctcccaaa attcggtgaa aaatagtgta aatagtcctc 397621 gcgggtgacc aaagaaccct ttttgcggga cgcttttaat gatactttcg ttatcaatcg 397681 aagccatgtc agccaaaccc tttctaaaaa aagtgtatta taaaaatcat attcttatat 397741 aatacttgtg tcaatataat ttatactcat ttcaaatagt tccatattgg aaaaattata 397801 aatacctaaa aatagtgatt tcctcctaat ttttaaactt tttatcgtga gattttctta 397861 cacaactatt cctttatatt tttttaataa aattttagag aaatgtacaa gcagatcggg 397921 aggaccgctg gtgaatcaat cccctgtaac ggggattttt ttatgtccgt aaaccgcttt 397981 gaaaagccgc tgcacaccct cctgaatatc ttcttccttc agccgtgcaa agccgataat 398041 gagagcaggc ctgcccgttt gccgcttgtt ttccttcaag ttaaatcggc tcattccgaa 398101 tatttcaagc tgcagcccgg cagcatgtga caggatgtct tgttcggtgc gcctggtatc 398161 aaattcggta acaaaatgca gccccgcatt tgcccctttt acggtaacct ctccgctgaa 398221 ctctgcttct aaagcggtga tcaggcgttc tctcttttct ttataatgct gcttcatttt 398281 ttttatatgc ttctgatatt caccagactc gataaattcc tgcagggtga gctgtgtgag 398341 tgatgagcaa gtctgcagat catagccccg ctgtttgtat gccctcaaca gctcaggcgg 398401 caacaccata tagctgatcc gtaagccggg gagaagggac tttgaaaagg ttcccatata 398461 gatgacattt tgaaaacggt cgaggctttg cagcgccgga atactgtcta catcatatgt 398521 gaattcacta tcataatcgt cctcaatgat atatcggcgc ggctcctcgg ctgcccagtt 398581 cagcagctga attcttctgg atacaggcat aatcgttccg gacggaaact gatgcgacgg 398641 ggtggtcacc agcacatctg gctgctgtct ggtgatttca gcaatcgaca tgcctttttc 398701 atccagcatg atcgtcttta cttgttttcc ggcattcttc aaaagctgat acatgcgcct 398761 gtagccaggc tcctccatcg catacacggc ttccttgggt aaaagctcag tcaacagctg 398821 catgagcacc tgtgtgcctg cccctatgat catttgttcc ggcctgcatt ttacacccct 398881 cgtcagggaa atgagcctcg taatggccgc tctcacttca tatatccctt gcggatgtga 398941 catatcgccg agcgtgcggt atgagcggga ggccgctttt tgctcgcagc ggaaccagct 399001 tttgatcgga aaatggtctg tatcggaact catgtgtgaa aacgatatcc aatcgctctg 399061 gtcgatgtga atctctttta ggtcatccgg cagtgcaaat ggagggtgct cctcggcgga 399121 aaacatgtct agttcctcca cgaagaaacc ctttcgttca atggcgtaca aatacccctc 399181 agccagcagc tgctgatagg ctgaattcac tgaatttacg ctgaccttga gattttcagc 399241 cagctcccgc ttggagggaa ccttcgagtg cggcagcaga ttgcggctga ggatttcttt 399301 tttcagcttt tgataaattt gctgatagat ataatcggct tgttctgaac gatcgagtgt 399361 aatcgtgata tccattttgt agtttctcct tctgatacca tcaaaaagtt ataattggta 399421 cttttcatca taccaaagag aagtcagaat gataagaaaa taccgacagg gggatattca 399481 catgagtcaa acaacagcaa gcatcacaac tgcacaatgg cagcaaaaac gggatcaatt 399541 tgtgtcaaaa ggtgtgagca acggcaaccg cagtctggcg gtcaaaggag aaggggccga 399601 gctgtacgat ctggatggcc ggagatttat tgattttgca ggcgccatcg gcacgttaaa 399661 tgtcggacac tcgcatccga aggtggttga ggctgtgaag cggcaggcgg aggagctgat 399721 tcatcctggt tttaatgtca tgatgtaccc gacttatatc gaattagcag aaaaactgtg 399781 cggcatcgcg ccgggcagcc atgagaaaaa agcgattttt cttaactcag gggcagaagc 399841 ggtcgaaaac gctgtgaaaa tcgccagaaa gtatacaaag cgccaaggcg ttgtctcgtt 399901 tacacgcggg tttcacgggc gcacgaatat gacgatgagc atgacaagca aggtaaaacc 399961 ttataaattc ggtttcgggc cttttgcgcc agaggtttat caagcgccgt tcccttatta 400021 ttatcagaag ccggccggca tgagtgatga aagctatgac gatatggtca ttcaagcatt 400081 caatgatttc tttatcgctt cagtggcgcc tgaaacggtg gcgtgtgtcg tgatggagcc 400141 agtgcaggga gaaggcggat ttattattcc ttcgaaacgg ttcgtacagc acgtcgcttc 400201 attctgcaaa gaacacggca ttgtttttgt tgctgatgaa atccaaaccg gctttgccag 400261 aactggcact tatttcgcaa ttgagcactt tgatgtagtg cccgatctga tcacggtttc 400321 taaatcgctt gcggcaggcc tgccattaag cggtgtgatc gggcgtgcgg aaatgcttga 400381 tgcggcagcg ccaggggagc tgggcggcac gtatgccggc agcccgctcg gctgcgcggc 400441 ggctttggca gtcttggata ttatcgaaga agaaggactg aatgagcgat ctgaagaaat 400501 tggcaaaatc attgaagaca aggcgtatga gtggaaacaa gaattcccgt tcatcggtga 400561 catccgcaga ctcggggcga tggccgcaat cgaaatcgtc aaggatcctg acacgcgtga 400621 gcctgataag acaaaagcag cagcgatcgc ggcctatgcg aatcaaaacg gattactttt 400681 gctgacagcg ggaattaacg gtaatatcat ccgctttttg acaccgctcg tcatctcaga 400741 cagcctatta aatgaagggc tcagcatctt ggaggcgggc ctgcgagctt aatcattgga 400801 aagaaaatgg ccgggtctgc tatcatttta agtaatcatg aaaagaaagg aatgttcaat 400861 atgccagatc aattaacggt ctacaacccg gctacgggcg aggagatcaa aacgattcct 400921 cagcaatcag ccacagaggt agaagaagcc attgaacgtt cacatcaagc gtttaaaacg 400981 tggtctaaaa catcagcgaa cgaaagaacg tctcttttga aaaaatggta tgagctgatt 401041 gttgaacata aagaagagct tgcagattta attacaaagg aaaacggaaa accataccag 401101 gaagcagtcg gcgaggtact ttacggcgca ggctatatcg aatggttcgc agaggaagcg 401161 aagcgtgtgt acggaagaac ggtcccggcc ccgacaactg gtaaacgaat tgttgtcaca 401221 cgccagccgg tcggccccgt tgctgctatc acgccctgga atttcccgaa tgcgatgatt 401281 acacgcaaag cggcgcctgc tcttgccgcc ggctgtacat ttatcatcaa gccggcgccg 401341 gacacaccgc tgtctgctta tgaactagcg cgcctcgcat atgaagcggg cattccgaag 401401 gatgttcttc aggttgtgat cggcgatgga gaagaaatcg gaaatgtgtt cacaagcagt 401461 ccgaaaatcc gcaaaatcac gttcacaggc tcaacacctg tagggaaaat ccttatgaaa 401521 aacagcgctg acaccgtaaa gcacgtctca atggagctcg gcggacacgc cccgctgatc 401581 gtagatgaag atgcggacat tgaccttgcc gttgaacagg cgatggcgtc caaataccga 401641 aacgccggcc aaacctgcgt atgtgccaac cgcctgatcg ttcatgaatc cattaaagat 401701 gaatttgctg cgaaactgag cgagcaagtg tctaagctga aagtcggaaa tggacttgag 401761 gaaggcgtca atgtcggccc gattatcaac aaacgaggct tcgaaaaaat cgtcagccaa 401821 atagatgatg cggttgaaaa aggcgcgaaa gtgattgctg ggggcacata tgaccgaaac 401881 gatgacaaag ggtgctactt tgtgaatccg acagtgctca ccgatgtcga tacgtccatg 401941 aacatcatgc atgaggaaac attcggcccg gtcgccccga tcgtcacgtt ttctgatatt 402001 gatgaagcga ttcagcttgc caacgataca ccgtatggct tggctgctta cttcttcaca 402061 gaaaactacc gccgcggcat ctatatttcc gagaatctag agtatggcat tatcggctgg 402121 aatgacggcg gaccgtcagc ggttcaagcg ccattcggcg gaatgaaaga aagcggcatc 402181 ggccgtgaag gcggttcaga aggtatcgag ccgtaccttg aaacaaaata tttgtccatc 402241 ggtttataaa agaatgcacg ctcctgagag ctgccggatt ttccggcagc tctttttgtg 402301 ttccggcgaa taatcacaac aattccagcc aaaataacag caaatacatt ttgaaagaag 402361 gttccccaac aatggattta ttattggctc ttctcccggc tttgttttgg gggagcattg 402421 ttctcttcaa tgtgaaatta ggcggcgggc cgtacagcca gacactggga acgacgatcg 402481 gggcactcat tgtttctatc gttatttact tttttgttca gcccgttctg tcccttcgca 402541 tttttattgt tggaatcgta tccggcttat tttggtcact tggacaggcc aaccagttga 402601 aaagcattca attgatgggc gtgtcgaaaa caatgccgat ttccacagga atgcagctcg 402661 tttccacctc gctgttcggt gtgatcgtgt tccgcgaatg gtcaacaccg attgcgatta 402721 cgcttggcgt tctcgctttg atctttatca ttgtgggaat cattctcacg tccttggaag 402781 ataagaatga taaaaaagag ggcgagccaa gcaatttgaa aaagggcatt ttgattctcc 402841 ttgtttcgac tcttggttat ttggtttatg tagtcgtggc tagattattc aatgtgtccg 402901 gctggtccgc gctgctgcca caggcaattg gcatggtggt cggggggtta gttttaacct 402961 atagacacaa accctttaac aagtatgcga tcagaaatat tctcccaggg ttaatctggg 403021 caggcggaaa tatgtttttg tttatttctc agccgcgagt cggcgttgca acgagctttt 403081 ccctttcaca aatgggaatt gtcatttcta cgctcggcgg tattttcatc ctgcgtgaaa 403141 agaaaacgaa acgccagcta atagcaattg cgatcgggat tatcctgatt attgccgccg 403201 ccgtattctt aggaatcgcc aaaacaaatt cataacaaat ggaggaggat gtatatgtat 403261 ccggatttaa aaggaaaagt cgtcgctatt acaggagctg cttcagggct cggaaaggcg 403321 atggccattc gcttcggcaa ggagcaggca aaagtggtta tcaactatta tagtaataaa 403381 caagatccga acgaggtaaa agaagaggtc atcaaggcgg gcggtgaagc tgttgtcgtc 403441 caaggagatg tcacgaaaga ggaagatgta aaaaatatcg tgcaaacggc aattaaggag 403501 ttcggcacac tcgatattat gattaataat gccggtcttg aaaatcctgt gccatctcac 403561 gaaatgccgc tcaaggattg ggataaagtc atcggcacga acttaacggg tgccttttta 403621 ggaagccgtg aagcgattaa atatttcgta gaaaacgata tcaagggaaa tgtcattaac 403681 atgtccagtg tgcacgaagt gattccttgg ccgttatttg tccactatgc ggcaagtaaa 403741 ggcgggataa agctgatgac agaaacatta gcgttggaat acgcgccgaa gggcattcgc 403801 gtcaataata ttgggccagg tgcgatcaac acgccaatca atgctgaaaa attcgctgac 403861 cctaaacaga aagctgatgt agaaagcatg attccaatgg gatatatcgg cgaaccggag 403921 gagatcgccg cagtagcagc ctggcttgct tcgaaggaag ccagctacgt cacaggcatc 403981 acgttattcg cggacggcgg tatgacacaa tatccttcat tccaggcagg ccgcggttaa 404041 acataaaaag cgacccagac atgacatctg gatcgctttc tttattaggc acgctttttc 404101 tttacaagtg ctgctacaga taaaataatg gcagccgcag acagcaccat cgctgtaatg 404161 tctagagctg aagaacctga gttttcggaa tcgtcttctg ttttcgtggc gccgtgctca 404221 tctgtcactt gctttgcaga cgtgatgttt gtaatggaat gaggtgtatc ggcatcctcg 404281 tcacctgtcc actcaacaat gctgccgtct ttgtaatatt ggtatgcgtc ccaagcagct 404341 tcctccgctt tgtcagggtt tttggcaaca aaggtaaact gctggaactg gccttcctga 404401 atgcctccgt cagtcgcctc ccatgtcacg gatactgatt tgtcatcatg tttttgagtg 404461 gaaaccttcc agcccggaat tggctcatat tgctggaatt caacatcctt cggcattttg 404521 aggacaacct tcgttgtcgg cagatttttc tcagaaggaa ccttcattgt atacgtttcc 404581 caagagcctg cagcagactc agccggtttt acagaaacat gcgcgctggc aggggccgta 404641 aagaataaga gggagccgac aatagccgga catagtgtca atgcgatttt tttcaacaac 404701 gtaaacactc cttaattggt ctttgtaaac atgatattga tttcgttaaa gtcgccggtc 404761 aggccgtgga ctttgatctt ccagtttcct ttttcattaa tcgacaggtt ttgatcttgg 404821 aagacgcctt ttgttttttc ttttaatgta aaggtgcttt tgttttcgct gcctgacagg 404881 cctgttttat aaacggttaa cgtgatttgc tggatgtttt tcacgggatc accgttatgg 404941 tcggtgaccc gcagctcaaa aacatttttt ccaggctggt ttgggctgat gctgagagaa 405001 acgctttgtc cgttctctat cgctttggtt tggtagaacg gttccggcgc tggctcaggc 405061 gggcttggca ggcttgtaaa cacggccgct gtgatcaata cagcgatgcc gattgcccac 405121 tccgctttca acgttcggct gattcctgtg cggcgctgct ttctggtaag cagaaaatga 405181 attgcgccta agaccagcat gaaaacaaac agcccgcttt tcactaaaag agcttgtccg 405241 tacgctgtat ggaacagtga atccattgaa cgaatgatga aaaatccatt gagcaagcct 405301 gaaaacaaaa tgacgccgac tgcagtgagc gcccatgggg agaaccgtct gaccgtctcc 405361 cacgcgagcg ttttgtcagg ctgcctccat tcttttgaga gcagcaaaac gagtgccgct 405421 attccgccga cccagatgga agcggaagtt aaatgaagga aatccatcaa aatgccgacc 405481 gttttttctt caacgacagc agcatgcccg gtaaacgcct tggcaagcag gagaccgaaa 405541 aagaaaatga gcggcgctgt ccaatagcca aaggatgaaa agcggttttt ccgtatcgca 405601 gggatgacag acagtgcgag cagcacgaac agcgcagcct gtatgatcca aatggagccg 405661 cctgctgtct caaacagtgt ttctctgatg tagcccggct ggaatgcgct gccccagccg 405721 ccgcctgcgt tcgcttttgt ctgaatcgga agctgaagca aaagcgccag ccccaatgct 405781 gcgatcgagc cggtcaggat acgtctcgtc cgtttgacga gctgttctga tttcccttta 405841 taccagaaaa gatggaagaa aaccgttccg ataaacagag ataaggctgt atacagaatc 405901 gcgcgatctg ctgctgttcc cggattcagc gctgaatcgg ctgctttttg gctgctgaat 405961 ccgccatccg ctttcccgat actgaacgga atgacgccgg aaacaggatg tccatccgcg 406021 gatacggcat tccattccgc tctgtacaca tctttaggca gattcttctt cagcttcact 406081 gtcatgatgt gatgattatc ttttttgatt tcagtcttgt ccgtatccac acggtcgccg 406141 tttgaattat agactttaat gtaatgaaac ccttcttcaa ccggttcatt aaattcgatt 406201 tccacctgcg caggggcgct ttttaattcg ctgttttccc caggtgaaga tttgacaata 406261 taggcgtgag caaagcttgt tttcggcagg aaaacaagaa aaagcagaag gatgatccac 406321 catctgtttc gcttcatcac tcagacacca ccttccgctg tatgtgttgt gttatttctt 406381 ggtgcaggtg cagcgtttct ttcggtcttg aagcatgtct tccagcgctt ggtcgaaagt 406441 gcagacggct ccgccgaatc ctttttgaaa tcgttcggca tggtcaagtg tcgcaaacgg 406501 aatggcctgc ggctggcagc agtgcaggtt taattcagca tttacgacga aataagccga 406561 accggcactg acggttgtct gtaacagaaa atctctgcaa atcaagtgtg aaacctcttc 406621 cgttttatcc gcgtaacgca aaaacgcgca atgtgcgcag catagctgtt caatgtcttg 406681 gtttaccgta atcagctgaa ccgaatgagc ttgattgacg ggcttcaagc aatagctgca 406741 catatgatct gtttgaggtg ttcggacggg gagcgtgatg ccgccggccg ttttaatgac 406801 ctgatttgac tgaaccagct gattgacatc tctatatacc gtcatttccg aaacgccgaa 406861 ccttgcgctg atgtcagaaa ttctaagcga gccttcttct ttcagccact tcagtatgtg 406921 ttgctgtcta ttaatcggaa gcattcatac accctcttca ttaagatcta tttaagcgta 406981 gaggatttta gagacggaga caagtaagtg gatgataaaa aatgtgaaaa tgtgttgaac 407041 agcaacaaaa cgaaacagaa gggactctgg tataatagac agatggaata gaaagtgagg 407101 aataccctat gaaagaaaca ccatgcccga actgcggcaa acctttgaca ggcgatatgg 407161 tcagatcatc aaatgtgcct tgtcaatttc gctgcggcca ctgccgggaa cggctttatg 407221 aatataaagt ttcagctccg attatgctgg tatcattagc ggccatcgtg ctgcttattt 407281 atcttttgat gctcctccgc aatgcggcag gctcagtgct gccagctgta cagcacgtgc 407341 cgatggctgt atttgcgctt gtgtgcgcgt atcccgtttt tattgtgagt gagcggatga 407401 ttgcaaagta cgtgattcaa aatggcaaca tcatttatag aggaaagaga aaaggctcct 407461 gaaaccagga gcctttttat ttttaaaaaa ttgtcacagt catgtgccaa agtcctcttt 407521 actttcaatt gtatagggac tgtaagcgtt ttaacataga gtcaaaggga agcatcattc 407581 tctgaacata tttttgtatc ttacagcgac aaacaaaaca gggagggttt atatatgcag 407641 cagcaagaac agcagcaagg cggcatgaaa gtgaaagtgc aacgctttgg gagttatttg 407701 agcggaatga tcatgccgaa tatcggcgcg tttatcgcgt ggggtatcat taccgcgctg 407761 tttattccgg caggatggtt tccgaatgaa cagctgaaca cgctggtcag cccgatgatt 407821 acgtatttat tgccgctttt gatagcgtat acaggcggaa aaatgatcta cgaccaccgc 407881 ggcggagttg tcggagcgac agcggcaatt ggggtgattg taggatcgga tattccaatg 407941 tttttaggcg caatgattat gggtccgctt ggcggatacc tcattaaaca gactgataaa 408001 ttattcaagg ataaagtcaa gcaaggcttt gaaatgctga tcaacaactt tacggcaggg 408061 attgtcggcg cggctttaac gattctcgcg ttttacgcca tcggcccggt tgtcttgacg 408121 ctaaataaat tgctggcggc tggtgtggaa gtcattgtac acgctaattt actgccggta 408181 gccagtgttt ttgtagaacc ggcgaaagtg ttgttcctta acaacgccat aaaccatgga 408241 atcttaagcc cgatcggaat cgagcaagca tctcaaacag gaaaatcaat tctgttttta 408301 gtagaagcaa accctggacc ggggctcggc attttgctgg cctacatgtt ctttggcaaa 408361 ggatcttcaa aatcaacggc tcccggtgcg gcgatcatcc atttcttcgg agggattcac 408421 gagatttact tcccgtacat tctgatgaaa ccggccctga ttctcgcagc cattgccggc 408481 ggagcaagcg gactcttaac atttacgatc tttaatgccg gacttgtcgc ggcagcgtca 408541 ccgggaagca ttatcgcatt gatggcaatg acgccaagag gaggctattt cggcgtattg 408601 gcgggtgtat tggtcgctgc agctgtatcg ttcatcgttt cagcagtgat cctgaaatcc 408661 tctaaagcta gtgaagaaga cctggctgcc gcaacagaaa aaatgcagtc catgaagggg 408721 aagaaaagcc aagcagcagc tgctttagag gcggaacaag ccaaagcaga agaagcgtct 408781 gagctgtctc ctgaaagcgt gaacaaaatt atctttgcgt gtgatgcggg aatgggatca 408841 agtgccatgg gggcatccat cttaagaaac aaagtgaaaa aagcggagct tgacatcagt 408901 gtgaccaaca cggccattaa caatctgcca agcgatgcgg atattgtcat cacccacaaa 408961 gatttaacag accgcgcgaa agcaaagctg ccgaacgcga cgcacatatc agtggataac 409021 ttcttaaaca gcccgaaata cgacgagctg attgaaaagc tgaaaaagta atcttataga 409081 aagagagtga ttgtcatgca agtactcgca aaggaaaaca ttaaactcaa tcaaacggta 409141 tcatcaaaag aagaggctat caaattggca ggccagacgc tgattgacaa cggctacgtg 409201 acagaggatt acattagcaa aatgtttgaa cgtgaagaaa cgtcttctac gtttatgggg 409261 aatttcattg ccattccaca cggcacagaa gaagcgaaaa gcgaggtgct tcactcagga 409321 atttcaatca tacagattcc agagggcgtt gagtacggag aaggcaacac ggcaaaagtg 409381 gtattcggca ttgcgggtaa aaataatgag catttagaca ttttgtctaa catcgccatt 409441 atctgttcag aagaagaaaa cattgaacgc ctgatctccg ctaaaagcga agaagatttg 409501 atcgccattt tcaacgaggt gaactgacat gatcgcctta catttcggtg cgggaaatat 409561 cgggagagga tttatcggcg cgctgcttca ccactccggc tatgatgtgg tgtttgcgga 409621 tgtgaacgaa acgatggtca gcctcctcaa tgaaaaaaaa gaatacacag tggaactggc 409681 ggaagaggga cgttcatcgg agatcattgg cccggtgagc gctattaaca gcggcagtca 409741 gaccgaggag ctgtaccggc tgatgaatga ggcggcgctc atcacaacag ctgtcggccc 409801 gaatgtgctg aagctgattg ccccgtctat cgcagaaggt ttaagacgaa gaaatactgc 409861 aaacacactg aatatcattg cctgcgaaaa tatgattggc ggaagcagct tcttaaagaa 409921 agaaatatac agccatttaa cggaagcaga gcagaaatcc gtcagtgaaa cggtaggttt 409981 tccgaattct gccgttgacc ggatcgtccc gattcagcat catgaagacc cgctgaaagt 410041 atcggttgaa ccatttttcg aatgggtcat tgatgaatca ggctttaaag ggaaaacacc 410101 agtcataaac ggcgcactgt ttgttgatga tttaacgccg tacatcgaac ggaagctgtt 410161 tacggtcaat accggacacg cggtcacagc gtatgtcggc tatcagcgcg gactcaaaac 410221 ggtcaaagaa gcaattgatc atccggaaat ccgccgtgtt gttcattcgg cgctgcttga 410281 aactggtgac tatctcgtca aatcgtatgg ctttaagcaa actgaacacg aacaatatat 410341 caaaaaaatc atcggtcgct ttgaaaatcc tttcatttcg gacgatgtga cccgcgtagc 410401 gaggtcacct ctcagaaaac tgggagaaaa tgatagactt gtaggcccgg caaagaaaat 410461 aaaagaaccg aatgcactgg ctgaaggaat tgccgcagca ctgcgcttcg atttcaccgg 410521 tgaccctgaa gcggttgaac tgcaagcgct gatcgaagaa aaaggataca gcggcgtact 410581 tcaagaggtg tgcggcattc agtcccatga accgttgcac gccatcattt taaagaaact 410641 taatcaataa ccgaccaccc gtgacacaat gtcacgggct ttttttacta tctcgcaatc 410701 tagtataata gaaagcgctt acgataacag gggaaggaga atgacgatga aacaatttga 410761 gattgcggca ataccgggag acggagtagg aaaagaggtt gtagcggctg ctgagaaagt 410821 gcttcataca gcggctgagg tacacggagg tttgtcattc tcattcacag cttttccatg 410881 gagctgtgat tattacttgg agcacggcaa aatgatgccc gaagatggaa tacatacgct 410941 tactcaattt gaagcagttt ttttgggagc tgtcggaaat ccgaagctgg ttcccgatca 411001 tatatcgtta tgggggctgc tgctgaaaat ccggagggag cttgagcttt ccattaatat 411061 gagacccgcc aaacaaatgg caggcattac gtcgccgctt ctgcatccaa atgattttga 411121 cttcgtggtg attcgcgaga acagtgaagg tgaatacagt gaagttggcg ggcgcattca 411181 cagaggcgat gatgaaatcg ccatccagaa tgccgtgttt acgagaaaag cgacagaacg 411241 tgtcatgcgc tttgccttcg aattggcgaa aaaacggcgc agccatgtga caagcgccac 411301 aaagtctaac ggcatttatc acgcgatgcc gttttgggat gaagtctttc agcagacagc 411361 cgctgattat agcggaatcg aaacatcatc tcagcatatt gatgcgctgg ccgctttttt 411421 tgtgacgcgt ccggaaacgt ttgatgtcat tgtggcgagc aacttgttcg gtgatatttt 411481 aaccgacatc agctcaagcc tgatgggaag catcggcatt gcgccttctg cgaacatcaa 411541 tccatccggc aaatatccgt ccatgtttga accggttcac ggctcagctc ctgacattgc 411601 cggacagggc cttgccaatc cgatcggcca gatttggaca gcgaagctga tgctcgacca 411661 cttcggagag gaagaattgg gggcgaaaat tctggatgta atggagcaag tgactgccga 411721 cggcatcaaa acacgcgaca ttgggggaca aagcacaacg gctgaggtca ctgatgaaat 411781 ctgttcgcgc ttaagaaagc tctgatgaat caggccggtg gcagatggct gccccggcct 411841 gtccatttcc ttacgaaaat ttccacgaaa gtctaaccaa gcagatccaa atgctgtata 411901 ataatttgga attcttagga aagcatcggg tgaaggaagt tgaatgcaaa aacaatcacg 411961 ttaaagaaaa aaagaaaaat caaaacgatc gttgtactca gtatcattat gatcgcagct 412021 ctcattttta cgatcagatt ggtgttttac aagccttttc ttattgaagg atcatcaatg 412081 gccccaacgc ttaaagactc agaaagaatt ctggttgata aagcagtcaa atggactggc 412141 gggtttcaca gaggagacat catagtcatt catgacaaaa agagcggccg ctcatttgtc 412201 aaacgtttaa tcggtttgcc tggtgacagc attaaaatga aaaatgatca gctatacata 412261 aatgataaaa aggtggaaga accatactta aaggaatata aacaggaggt caaagagtcg 412321 ggtgtaacct taacaggtga cttcgaagtt gaggttcctt ccggtaaata ttttgtgatg 412381 ggagataacc gtctcaattc actggatagc agaaacggaa tgggcatgcc ttctgaggac 412441 gatatcatcg gtactgaatc tctcgtcttt tatccattcg gtgagatgag acaggcaaaa 412501 taaaatgcaa tgcaaaaaga acatggaaca tgacggcacc gataataaag cgccgtgcac 412561 gtttaaaaaa atgatgatga aacggtgcgg agccggcttt ccgccccgtt ttttatgata 412621 gaaagcgttt tgaagaaaag ggccctgttg aaataaacag aatcaggatt ggcgaagccg 412681 tgaagcgcat cgaattggta aatctcaaga tgggtatgct gtttttcccg cagttttttg 412741 ataagaagcg ctacgtcaaa cgacggctca taattaggga aaaacaatag gaccgggcag 412801 gctggcatgt gatgaagaga gtcgcgtatc cgggaaccgt aataacaaac cgatccgctc 412861 acctcaggca tactgctgca tttccatgcg atagtagccc ccacgctgaa tccaatcaca 412921 aagatgtgcc gtccggcgtt ttgcctgatc acattctgga tgatggtttc tcccgttttc 412981 agcctttcgt gttttgtaaa ttgttcgtat gccgtttttt cttctttcag tgtgtagact 413041 tcatcctcgc cgagcaggtt gggcgtcaac acatcatatc cagccatttt gatcagccgg 413101 cccatctttt tcatatggct gtttacacca tatatttcgt gtgcgagaat gacaagcggt 413161 tttgggaaca taacggcctc cttttgtgtt ttttccatta tatcctatcg tttcacttta 413221 ggctgagata taatggtcaa aaaaaggaga tataaaatga actcattatc tttgcctcac 413281 cgctatccat ttttgtttat tgatggcgtg acggatagcg agcccggcaa acatgcggca 413341 gcttataagc tgattagtga gaacgactgg tttatcactg atacgcaaac agaaatgccg 413401 ttttcacttg tgattgaagc gcttgcgcaa accgcggctt ttacaggaat tacagatgag 413461 aacagcttgg gattattgtc ttcggtgaag aaagcggaaa agctgggaga agctgtgcct 413521 ggtgaccggc ttgatcttac gtttgaagtc acgcgcaatc ggcgcgggtt tgtgttcgga 413581 catgccaagg catcagttgg agagcagcct gttgctgaag ctgaaatcgg catctatatt 413641 gaaaaatgaa aaaaaccctt cacaacattt tgtgaggggt tctattttgt gtcgtaatcc 413701 cgttcgcttt gagagttatc tctttgctgg cgtttgtgtt tttcatcatt catattttcc 413761 ttcagctctt cattaggaat cggatcggtt aagtcgttgt gctcggggtt ttcatttggt 413821 ttgttttgct gttttttttc tgtcatgttt gatcacctca ccgtttgttt tcctcttatt 413881 cattctcctc aaacatagga aatcgctttt ttgtcccgct gggtataatg tattagaata 413941 gagagaagca caacaaaaag ataaagagag gtacatatat gtctgttcaa agagaagatg 414001 tagatatcaa gctgatcgca attgatatgg atggtacact gctgaacgac gagcagctga 414061 tctcggatga aaaccgcaaa gccattcgtg aagcggagga taaaggtgtg tatgtggtga 414121 tcagcacggg ccggacgctg atgacgtgca gggagctggc ggaatcgcta aagctgtcat 414181 cctttctaat cacggcaaac ggcagtgaaa tttgggattc gaattttaat ttggtggaac 414241 ggaagctgct tcatacggac catattcaaa tgatgtggga tttgcggaat aagcacaaca 414301 ctaatttctg ggcttctacg gtgaataaag tatggagagg cgagtttccg gaaaacatta 414361 cggatcatga atggctcaaa ttcggctttg acatcgagga tgacgatatc cgaaacgaag 414421 tgcttgagga gctgagaaaa aacaaagagc tcgaaatcac aaattcaagt ccgacaaaca 414481 ttgaagtcaa cgcgcttggc atcaacaaag ctgcagccct tgccaaggtt acggaaaaac 414541 tcggctttac aatggagaat gtgatggcga tgggcgacag ccttaatgac attgcgatga 414601 tcaaagaagc gggtcttggc gtcgcaatgg gcaatgcgca agacatcgta aaagaaacgg 414661 ctgattatat cacggataca aatattgagg atggtgtcgc taaagcgatt cgccattggg 414721 tactataaaa aaagagagtc ctaagatgga ctctcttttt tagtttggca ggttttattc 414781 tgggaccatg gtaggttttc tgacaaaagt atttcacaaa ctgatatgat tcacttataa 414841 tgaaataaag ttcaaaaatt cggaatagtc gttccgaatt tcgggacaat aaatgacata 414901 aagcatatcg tttgctttgg caggagggat tctgtgtttc agattgattt aaactgtgat 414961 ttaggagaaa gcttcggagc ctacaagata ggccttgacc aagatatttt agagtatgtg 415021 acatcagcga atatcgcatg cggatttcat gcaggagatc ctagtgttat gcgaaaaacc 415081 gtcgcgcttg cagcagaaag aggcgtgaaa atgggtgcgc atccgggctt gccggattta 415141 ctcggttttg ggcgccgcaa tatggcgatt tctcctgagg aagcgtatga tcttgtcgtt 415201 tatcaaattg gcgcgctctc tggctttcta aaagcagagg gacttcacat gcagcacgtc 415261 aagccgcatg gcgctttata caatatggcg gcagtcgatc aaaaactgtc ggatgctatc 415321 gcgaaagctg tctataaggt tgatcccggc ctgattcttt tcggtcttgc tgagagcgag 415381 cttgtaaaag cgggagaacg gatcggactt cagaccgcaa atgaagtgtt cgccgacaga 415441 acataccaat cggacggcac gctgacaccg cgctcccagc cggacgcact cattgaaagt 415501 gatgatgccg ccgtcaccca ggtcatcaaa atggtgaaag aaggggcggt caaatctcag 415561 caaggacatg atgtgtcatt aaaagcagat acagtctgca ttcatggaga tggagcccat 415621 gcgctgacat ttgcgcaaaa aatcagaaaa cagctcaaag cggctggaat tgaagtgaca 415681 gctatttcag aacagaggtc aacataaagg aggaacaata gatggagcag cagaaaaaga 415741 cagcaggaaa aaaagcgggc agctggtcat tgctgatggg cgccgccttt ttaatggcga 415801 catcagcaat cggaccgggt ttcctcaccc aaaccgcaac attcacaaac acactcgcag 415861 caagcttcgg ttttgtcatc ttaatctcta ttattttaga tattttcgcc caaaccaatg 415921 tgtggcgcat catcgcagtt tctggaaaac gaggtcagga aattgcgaat atggtgcttc 415981 ccggactggg gtatttcatc gccattctcg tcgtgcttgg cggactagct tttaatattg 416041 ggaatatcgg aggggccggg ctgggacttc aggtgctgtt cggcattaca cctgaaacag 416101 gcgctttaat cagtgccgtt atcgccattt tgatttttgt catcaaggaa gcaggaaaag 416161 cgatggaccg ttttacgcaa atcgcggggt tcgtgatgat tattttaacg gtctacgttg 416221 cggcgacgac agctcctccg gtcggacagg cagtcgcaaa tacattcgtc ccggaacaca 416281 tcagcatatt tgccattgtc accctagtgg gcggaaccgt cggcggttat atcacatttg 416341 ccggaggaca ccgtttgctt gatgccggaa ttaaaggaaa ggaatccatt ccgcaggtga 416401 caaagagctc ggttgtcggc attttaatta catctgtcat gcgtatcgct ctttttcttg 416461 cggttctagg cgttgtatcg aaaggcctgc acatcgatga aagcaacccg gcggcttctg 416521 tcttcaagct ggctgctgga aatgtcggtt ataaaatttt cggattgatc atgtggtctg 416581 cggcgattac gtctgttatt ggagcagcct atacatctgt ttcatttttt aaaacctttt 416641 ctccaaaaat tgaaaagaat tcacgcggta ttattatcgg atttattgtg gtttctacgt 416701 tagcttttgt cacaatcggc cagcctgcga agatcctcgt ccttgtcggt tcactgaacg 416761 gcttaattct gccgattgcg ctcggaacgc tgcttgttgc cgcctacaag aaaaacattg 416821 tcggtgatta taagcatccg ctttggctga caagcacagg cgcgcttgta gtgattgtaa 416881 tggcagttat gggaatctac acgttatgta cacaacttcc tcaattgtgg agctgatata 416941 agtggagcaa ttaaacaaaa tggcgccaaa ggatgtacgc gccctgatac gagaggggaa 417001 aataaacggg ccgaccgcag gcatgtccgg cggctacgcc caagcgaatc ttgtggtttt 417061 gaaaaaggac cttgcgtttg attttctgct gttttgccag cgaaatcaaa agccctgccc 417121 cgtgctggat gtgactgaag caggttcgcc tgtgccgtct ctggctgcgc cggatgctga 417181 tatcagaacg gactttccga aataccgtat ttacaggcac ggtatcctaa cggaagaagt 417241 atctgatatt acgccatact gggaggacga ttttgtcggc tttctgatcg gatgcagttt 417301 ctcctttgaa caggcactga tcaataatgg gatagctgtc cggcatattg atgaggggac 417361 aaacgtctca atgtataaaa cgaatatcga ttgtgttccg gcgggggcgt ttcacggaca 417421 gatggttgtc agcatgaggc cggttcctga acggctggct gtacgtgctg cacaagtgac 417481 ctcgcgtttt ccggctgtgc acggagggcc gatccatatt ggcaatccgg gagcaatcgg 417541 gattcgcgat ctcgggaaac cggatttcgg agatgccgtt tccattcgtg acggcgaggt 417601 tcctgttttt tgggcatgcg gagtgacccc gcaagccgtg gctatgaatg taaagcctga 417661 aatggtcatc acacatgcgc cggggcatat gctcatcaca gatattcgag acgagtcgct 417721 tgcggtgctg tagcctctcg tcatcctgat gaacgagaat taaaagaggt gagaaagatg 417781 actgtacgat atcaaatcga acagctcggt gattctgcaa tgatgatccg attcggagaa 417841 gaaatcaatg aacaggtcaa cggcattgtc catgcagcgg ccgcttatat agaagaacag 417901 ccatttccgg gattcattga atgtatcccg gcttttacaa gtctaaccgt attttatgat 417961 atgtatgaag tgtacaagca tttgcctcaa ggcataagct caccttttga gagtgtcaag 418021 cgcgatgtcg aagagcggct ggcagaaata gccgaagact atgaggtcaa ccgccgtatt 418081 gtagaaattc ccgtttgcta tggcggtgaa ttcggtccgg atttagaaga ggtggcgaag 418141 atcaatcaac tgtcaccgga ggaagtaatc gacattcata caaacggtga atatgtggtg 418201 tatatgcttg gcttcgcgcc cggttttcct tttctaggcg ggatgtcaaa acgcattgca 418261 gctccgagaa aatcatcgcc aagaccgtcg attcccgcag gttcggtcgg tattgcggga 418321 ttgcagacag gcgtttatcc gatttcaacg ccgggcggct ggcagctgat cggcaaaacg 418381 ccgctggctc ttttccggcc gcaggaaaac ccgccgacat tgctgcgggc gggagatatt 418441 gtgaaattcg ttcgcatctc agaaaaagac tatcacgcct ataaggagga gtccaattga 418501 gcatgaaagt attaaagccc ggactgctca caacggttca ggatataggc agaacgggtt 418561 accaaaaata cggcgttctg gccagcggcg ctatggacac ggtttcactg cgcattgcca 418621 atctgttgat aggaaacggc gaaaatgaag caggtctcga aataacgatg atggggcccg 418681 gtccgtcgtt tcatttttca aaacagacac tgattgctgt gacaggggcg gacttcacgc 418741 tgcgtattaa tgacgaggaa gcgcctttat ggaagcctgt gctcatcaag gaaaacagca 418801 cggtcagctt tggcccctgc aaactcggca gccgtgctta tttggcggca gctggcggca 418861 ttgaggtgcc tgccgtcatg gaaagtaaaa gcacatacgt cagaggaagc attggcggac 418921 ttcatggcag agcgcttcaa aaagaagatg aactgaacat tggagagatg tcagctcttt 418981 cgcaaaccat cctttctcgc ttaagttcgc agcttggaaa acagggattt gcagcaccga 419041 agtggtcagt cagccgcggc agatttctgc cattgaagaa gaatcccgtc attcgggtgc 419101 tggaaggaaa gcaatttgcc tttttcacag aagaatcaaa aacgcgtttt tatgaagaag 419161 catttcgtgt cacgccgcag tccgaccgta tgggctacag gctcaaagga gaaccgctcg 419221 aactgaaggc cccgcttgag atggtgtcgg aagcggtttc attcggaaca gttcaggtgc 419281 cgcctgacgg caacccgatt atcctgcttg cagaccggca gacgactggc ggctatccga 419341 ggatcgcgca catcatatcc gctgatcttc cgattgtttc ccaaatcatg ccgggcgagc 419401 acgttcagtt tgagcctgtg tccctccagg aggcagaagc gcttgcggta gaacgggaac 419461 agcatataaa agaactgaaa acgagaatga agatggaatg gctgacatag caaaggggat 419521 gaatgatgca gaataaaaat aaaaccgtag tcaaatctat ggcgctgctt aatttgtttt 419581 tgcataaacc aagcctaacc ttaagtgaac tggtgtcgct gacgggaatg ccgaagacct 419641 ctgttcaccg gatggtcagc tccttggagg aaatggggtt cctcagtcgg gatgcgtccg 419701 gcgcttattc gctgggattg gtgtttttgg aattcggaca gcttgtcgct gacaggctgg 419761 atatcagaaa aatagcgaaa ccggtgatgg aagagctgtg ccgggaagtg gatgaggccg 419821 tgcagttgat catgagggac ggcaatgaag cgatatacgt tgagaaaata gaagggacac 419881 agactgtgcg gctgtatacg gcgatcggca ggcgttcccc cctatacgcg ggagcgtgcg 419941 ccagaagcat tctgtccttt cttccccgtg aagaaatcga agcatacatc aaacaaaccg 420001 agctcatttc gattggctcc ggaacgatta ccgatcccga aaaactgctt caggagattg 420061 atgcctctgt gcaaaatggc tatactgtca gctattcaga gctcgaaaac tatacggcgg 420121 cgatcggcgc cccgatcttt aaccatgagc gccaggtggc agccggcatt agcattgcag 420181 gctttgaagc gagatttaca gaagacaggc tgccctattt aacagaaaag gtgaaggacg 420241 ccgctttaca gatttcaaga aaaataggat atacataagt agccaatctt ttctctgctg 420301 cgtacattaa cgtatcgacg ttcaagagtg gaggaaagaa catggtgctt cgatatacag 420361 ctctgggcga ttccttgacg acagggagag gctccgggct gttttcaccc ggcttcgtcc 420421 agcgttttgg ggacatgatg gaagctgact tgaaaacaag aacggcaata aacatatttg 420481 ccagatcagg tctgaataca gaagagattt tgggactcct gtcatatccc tatgtgcaaa 420541 aatgtattcg agatgctgat atgataacga tcacagggtg cggaaacgat ctcatcgatt 420601 cggtcttagc ctaccaaacc tctaaggatg aaacgatttt cagccgtgta tccgcccatt 420661 gccatgagaa ttttgaaaag atgattgcca aagtcgccga gattaaagga gaaaatcctt 420721 ccccgtacgc cattcgtgtg ttcaacttat acaatccgtt tcccgaaatt gatatcgccg 420781 gcaaatggat cacttcgttt aattcacatt tagaaacact tgcatcagca ccccatgtca 420841 aaatcgcgga tgcctatagc atcttcaaag gcaaagaaca ggaatatctg tcctttgacg 420901 gtgtccatcc gaacagcaaa ggctatcaag cgatggctga agccgttcac aagctaggct 420961 ataaagaatt atcagtttca tagaaaacgc gcctcatgac aggcgcgttt tttatgtgtg 421021 atcgaaatat taaaagaaac ttaaaattct ctgtcttctg ttctacagac aaacaaagtg 421081 cgctagaata atggagggcg taggcaaata tagccataac gttcaatatt tcgtatataa 421141 ggaaggatgg tccttttgtt tcggattttt aaaatgtctt ttgcggttat cattattata 421201 ctggcgctta ttgcttttaa ctatacggaa cacacctctg taatccaatc ggtcatgctc 421261 gtctttcttg gtgcggtcat gtttatgcag gggcttgaag agcgcaaaaa agaaaatgac 421321 ggctcaggcg cttttaatat ttataccgcc gtttttgtat ggtctgtctc ccttatcggt 421381 tttacacttc atattatata aatctattac acatcctgaa aatgctcgac cgtcgggaac 421441 ggggtataga accgatgaag caaggctttc cactcttgat actctgaaga accgcgaaag 421501 ccttccgtat ggtcctcaag tgtttcccac tccacaagaa gcagatattt atgcgtttcc 421561 tccatgcatt ttgataacga gtgagtgata tagcccttca tgccggaaat aatcggcgca 421621 gcttgccgga atgcatcctc aaactcttgt tcaaggcctt ctttaatgtg aagcattgct 421681 gcctctctga ccatgctatc ccttctttct gtcttttcaa atagtctaca gcaaacgata 421741 ggagatttct gcaaaatcgg tgaacttttc cttcattttc aaaaaaatct tgcacgcacc 421801 aattcaatta agagaaaata acaagtggaa ggcaggggaa agtcatgtta aaaaagtgta 421861 ttctactagt atttctatgc gtcggattga ttgggttaat cggatgctcc aaaacagatt 421921 caccagagga tcgcatggaa gcattcgtga aacagtggaa cgatcagcaa ttcgatgaca 421981 tgtatcaaag cctgactaaa gatgtcaaaa aagaaatctc caaaaaagat ttcgtcaaca 422041 ggtataaagc catctatgag caggccggcg taaaaaattt gaaagtcact gcgggagaag 422101 tagataagga cgatcaagac aacaagacga tgaaacatat cccgtataaa gtcagcatga 422161 acacaaatgc cggcaaagtc agcttcaaga atactgctgt gctgaaatta gaaaaaacag 422221 atgacgagga gtcatggaat atagattggg acccatcgtt tattttcaag cagctggctg 422281 acgacaaaac cgtgcaaatt atgagcattg aaccgaaacg aggccaaatt tacgataaaa 422341 atggaaaagg cttagccgtc aatacagatg ttccggaaat tggaattgtt cccggagagc 422401 ttggcgataa aaaagagaaa gtcataaaag aactcgccaa aaaacttgat ttgactgaag 422461 acgacatcaa gaaaaagctg gatcaaggct gggtaaaaga cgattcgttt gtgccgctca 422521 aaaaggtcaa gcctgaccag gagaaattag tttctgaagc gacgtcatta caaggcgtaa 422581 caagaacgaa tgtcagctcc cgctactatc cgtatggcga aaagacagcc catttgacag 422641 gctatgtccg cgccattaca gcggaagaac tgaagaaaaa gaaagaagga acgtacagcg 422701 atacgtctaa catcggtatc gccggacttg aaaatgtgta tgaagacaag ctaagaggca 422761 caactggctg gaaaatctac gtgccgcaaa ccggggaagt catcgctgaa aagaaagcaa 422821 aggacggcga ggatcttcac ctcacaattg atatcaaaac gcaaatgaag ctgtatgatg 422881 aactgaagga tgacagcggg gcggcagtcg cgctgcagcc gaagacaggc gaaacactcg 422941 cccttgtcag cgcgccttcc tacgatccaa acggatttat tttcggctgg agcgataagg 423001 aatggaaaaa gctaaacaaa gataaaaaca atccgttttc agcgaaattc aataagacat 423061 acgcgccagg ttctaccatt aaaccgattg cggctgctat tggaatcaaa aacggcaccc 423121 ttaaagccga tgagaagaaa acaatcaaag gcaaggagtg gcaaaaagat tcaagctggg 423181 gcggctattc agtgacacgt gtgtctgaga gacttcaaca agtcgatttg gaaaacgccc 423241 ttattacgtc agacaatatt tattttgccc agaatgcgct tgatatggga gcggacacct 423301 ttacaaaagg cttgaagaca ttcggttttt cagaggacgt tccgtacgaa ttcccgatcc 423361 agaaatcgtc tattgcaaat gacaagcttg attcagacat tttgcttgcg gatacaggct 423421 acggacaagg gcaaatgcaa atgtctccgc ttcacttggc aactgcttac acgccatttg 423481 ttgacaatgg agaccttgtc aaaccgacgc tgatcaaaaa agattcacaa acagctgatg 423541 tttggcacaa gcaagtggtc acgaaggaag gagcggcaga cattacaaaa ggtctgaaag 423601 gcgttgtgga agatgagcgc ggatcagcgt atcagcctgt cgtgaaagga atcacagtgg 423661 ctggaaaaac aggaacagcc gagctgaaaa catcaaaaga tgataaagac ggcacggaaa 423721 atggctggtt tgtcggctac gattacgaaa acaaagacct gcttgtcgcc atgatgatcc 423781 aaaatgtgca ggaccgcggc ggcagccact atgtcgttga gaaagcgaaa aagcaatttc 423841 aatcgaatta aaatgtcttt ttaaaaggag cgaaaggaaa aaggggatct gaggccgaat 423901 gaactagtaa gggggcaaaa cccggtttat acaaagaaaa gagggatttt gcatgcagcg 423961 tattcaattg gcggaggatc ttcaattttc aagagtcata cacgggcttt ggcggctgaa 424021 tgaatggaac tattcagatg ctgaacttct aagcctcatt gaatggtgta tcgatcacgg 424081 catcacgacc tttgatcatg cggatattta tggaggctat acgtgcgaaa agctgtttgg 424141 aaacgccctt gccctttcgc ctggattaag agaaaacata gagttggtca caaaatgcgg 424201 tatcgttctt gaatcgcctg aacggcccgc tcacagatcg catcattata acacaagcaa 424261 atcgcatatt ttggcatccg ttgagcaatc gcttatgaac cttaggacgg attatatcga 424321 tatgcttttg attcacagac cggacccgct catggatccg gagggggtag cagaggcgtt 424381 tcaggccttg aaatgctctg gcaaggtcag gtactttggc gtttcaaatt ttaaagatca 424441 ccagtatcgg atgctggaat catatttgcc tgagaagctc gtaaccaacc agattgagct 424501 ttccgcatac gaattagaaa atatgctcga cggcactttg aacctgtgcc aggaaaaacg 424561 gattccgccg atggcttggt cgcctctggc aggcggcaaa gtattcactg aaaacacgga 424621 taaagaccga cgtgtccgta cggcgcttga atccgtccaa ggggaaatcg gcgccgcttc 424681 attggacgag gtgatgtacg catggctgta tacgcatccg gccggcatca tgccgattgt 424741 cggaagcgga aagcgcgagc ggatttccgc cgcgataaat gcgttgtcat acaagcttga 424801 ccaggatcaa tggttccgca tttttacagc cgtacagggt tacgatattc cataaaaagc 424861 atcagtttac cagctgatgc tttttcaata ttgtcacacc gcttagtgcc aaattaccat 424921 ttataagtga ttgattcttt cttgaaagcg ttttatatta aaaggaaacc tctctatatc 424981 ctctactgca tctccttgcg acttcatccg cacatcaaga ttggctagga ggtctttttt 425041 atgtatatga ctgccagaga acaaaagctg ttaaagcact tattattaca aaacagatat 425101 ataaccgtaa ctgagcttgc tgagctgatg caagtcagca cgagaaccat tcacagggaa 425161 ctcaaatcaa ttaaaccgct gatggaaacc gtggggctta cgttagataa acagcccggt 425221 aaagggttga aagcagtggg aagtcccgag ggtaaacaaa agctgcttac tgatttatca 425281 tatgaacagc atgaatacag cgccgacgaa cggaaactgc tcattctttg ttcgttatta 425341 gagtctcagg agcccgtcaa actgtacacg cttgctcatg atctccaggt gacgaatgcc 425401 acggtcagct atgacttaga tgagctcgag aagtggattt ctccctttgg actgacactg 425461 atccgcaaaa gaggttttgg catccagctc atagggccgg agaatgcgaa acggaaaatt 425521 gtcggcaact tgattgtgaa ccgtctcgac atccaaatgt ttttggaagc ggttgaatta 425581 aacatcaaag gaaaaaccga ttcttcagag aaaatgttcg gggttgtcag caaaggtgag 425641 ctgttaaaaa tggagcgcat cttatttcag ctcaaagaaa aaatcgcttt ttcattgtcc 425701 gacagctcct atatagcgct cgtcgtccat ctgacgtatg cgatcgaacg aattaagctt 425761 ggggaaacta tcaccatgga gcaaaatgag cttgaggaac tgatgaatgc gaaggaatac 425821 agctccgctc ttgaaatcgc gggcgagctt gaacgtgcct tcggcgtgac gattccagag 425881 gcggaggtcg gctatattac aatccatctt cgaagcgcca atcgaaaata caaaacagaa 425941 tacaaagcgc aggaaattga gctggaaaca gccctgcaaa caaagcggct cattgctttt 426001 atttcagaca aaatcagaat ggatctgacg aaaaactact ctttatatga aggcttgatt 426061 gcccatttgg agccggccgt cagccgcata aaagaaaata ttgagatata caatccgatg 426121 aaggaacaga tcaagcgcga ttattttctg ctttatatgg cgatcgaaga aggtgtcgaa 426181 aagtattttc cgggcatgtc cttttctgat gatgaaatcg cttttatcgt tcttcacttt 426241 ggctcggctc ttgaaatcaa aaaagaagaa gcaaaagtga aagcgcttgt cgtctgctca 426301 agcgggatcg gctcctcgaa aatgcttgcc tccagactga aaaaagagct gccggaaatt 426361 gaatcgtttg atatgtcatc tctgatcgag ctaaagggga aggatgttca agcctatgat 426421 atgattgtgt ccactgtacc gattccttat gaaaacattg attacatcat ggtcagccca 426481 ctattaaatg aggaagacgc aaaccaggtc aagcagtata tcaagcggaa gattcccctt 426541 attcttaaca aaaaaagaag ctcgaaggaa gaggcgcagc aagctgatgt acctgacatg 426601 ctggaggcgg cggaaagcat agggcggtat atggaagtta tccaagatgt tctgcgccat 426661 tttacgctag ctcaactcaa aacaaacccg gaccatagca tgcttctgct agagcttttt 426721 caacagctga agaaggatgg cctgatccgt gatccggaaa aagccgcggt ttgcctggct 426781 gagcgggaga aacaaggggg attgggaatc cccggaacaa acatggcgct ttatcatctc 426841 aaaaatgatg aaatcgtcct gccttttttc aaaatgtttg atctcagcac cccctatgaa 426901 gtggatggca tggacggaaa taccctcagg atgacacgca ttctcgtcat gatggcgcct 426961 ggctcattat ctgctgaagg ctcggagatt ttaagcgcga tcagctcggc aattatcgag 427021 agcggagaaa gcatggcggg gtttcaggaa gaaggaggac aagaattgta tcagcggtta 427081 aaccgcatat ttttcacatg gatgaaagaa aaaaacatac tgtaaacctg catggcacac 427141 gtcaaaaatt tggcgtgtgt ttttctgtgg atggggaaca aaataagaaa atgtgggact 427201 attttatcat tcagtattgg aataattcca aaatgaaata gttttacaag ttatcttttt 427261 tgggttaaaa tgggtgaggt aaggaagaaa atctaacaaa ttattgaaga ttcaagagaa 427321 tataggagat gacgatatgg aaacattaca gcatctgatt ctgcatgaca tgccgaatag 427381 cgaagaaata gaggctgtaa aaagcggaga ccatacactg acatataaag gttaccgtaa 427441 acggattaat cagctggcga atgccatgct tcaaaaagga attcaaaagg gcgaccgtgt 427501 tgcattgctt tgcaaaaacg gccatcccgc ctcaactgtt atgttcgccg cacttgaaat 427561 aggtgctgtt gtcgtacctg tcagctggca gctgaaacca tatgaaatga caggcatttt 427621 aaaagcaagt gaaccaaaag cgatgtttta cggagcggag tttaaagaga tactggatga 427681 agttcttcct gaattgtcct cactgtgtgt aacaatggaa acaggaacag cttacgaaac 427741 atctgctgaa tttgaagcgc tgtttgcagg tcctgatcat ttgccagaga cggaaatggt 427801 ttcacctgat gatacagcac ttctgatgtt tacatctgga acaacgggaa acccgaaaag 427861 atgcatgatt acacatggcg gcatatacag atacgttaaa aaatccaaca gctcaatagc 427921 acgtatgaag ggccttcgtt ttctcgcgtg ccatccgatt tatcatacga gtgcgctcat 427981 ttgcatcatg cttggaacgt ttgcagaaac aacatttgtg tttacaaagg atcaagatcc 428041 tgttcacatg ctgaaggtca ttgaagaaga gaagattcag accgtgatgg ctcttcctgt 428101 gttctacacg tatttgcttg aggcgtggga aaagcaccaa actgacttat cttcgcttgt 428161 tattttaatg acaggcggaa caaaagtgcc gagcagccta ataagccgct atcttgatat 428221 tggcattccg cttgcgcatg gctatggaag tactgaggct tggggcatca gcacatggac 428281 gcctgatatg ggaatggata aagcggcatc tgcaggaaaa cctgtggcag gtgttaaagt 428341 caaagtggaa gatcctctga ccggagaaga acttcctcaa ggagaaatcg gcgaaatcgt 428401 tgttcatact ccattcttat ttaaaggcta tgaagacaat cctgaagcaa cagcgaaagt 428461 gctgcaaaat ggatggttta gaaccggaga ttcaggatat gtagatgaag atggctttat 428521 tttcatcacg ggacgctaca aggatgtcat tatttacgga ggcgataacg tctatcctga 428581 tcaggttgaa gaagttatcc agcagatccc gggaatcctt gaaacggctg tggtcggtat 428641 tcctgacccg ctttacggtg aaaaaccgaa agcttttatc gtgaaaaatg gcggccagcg 428701 catcacggaa gaggatgtca tcgcattttg taaagaacgc ctgtccgctt acaaaatacc 428761 tgaagttgaa tttgttaacg aactgccgaa aaacaacctt ggcaaggtga aaaaagacgt 428821 cctgcgcaat caggctgtac attcataaaa gaagaagccc gtccacttta tgtggcgggc 428881 ttctttgcag ttgcacagac ggaaagctca ggcttaatgt tcttaaattg tatatcaatg 428941 tcttcgaagc cggctgcttt aaagtcagca atcatctgtc ttccaaatga tttggttttc 429001 tcaggactgg catccgcttc ccgcggctgc atcgtaatgg ctgctttgcc gcctggcttt 429061 aatgcccgat aaatctgttt tatgcctttt gtttggtcat tccaaatggt gtagttgtta 429121 acggaaatca ctttatcata aaacgaggcg gggagaggaa atgtctcgat gcttccttgt 429181 atcaggcgta cgccctttgg tttcactctg cgggcggcca gcttcagcat ggcctctgat 429241 acatcaatcc catgaagatg aacatccttc tcgcgtttca gcatctgctg catgcagtat 429301 cccgggccaa acccgacttc taaaatgctg tccccgcgcg tgatacccag ctgattgatt 429361 gtccactgat tcagtgtttg attttcagca gccatgatgt acccggcaat catgccgatg 429421 acgccctttg gcctgctgaa tcttctagaa agcatgttaa tcattcagca accaaccccc 429481 tttttgagtt aatttcctct cagcgttcca tgtgaaacat ttttctgata aagcaatgcg 429541 aaggtgccaa gccatgttta tccaaagagt gtgtgaggta cacaacaaat agacatgaaa 429601 acaaaggagg agaatcatca tggcaaatta tccaaaagaa ctgccggcac aaactcaaag 429661 tcgccagccg ggaattgaaa gcgaaatgaa tccaagtccg gtgtatgagt acgaggatta 429721 taaaggagca gacaaattaa aaggaaaagt agctcttatt acaggcggcg acagcgggat 429781 cggacgcgcg gtttccgtcg cttacgcaaa ggaaggcgca gacatcgcca ttgtgtataa 429841 ggatgagcat gaagacgctg aggagacgaa gaaacgtgtt gaacaagaag gcgtaaaatg 429901 cctgctgatt gctggtgacg taggtgaaga ggaattctgc aatgaagcgg ttgaaaaaac 429961 ggtcaaggaa ctaggcggcc ttgacatcct tgtcaacaat gcaggtgaac agcacccgaa 430021 ggaaagcatc aaagatatta cgagcgaaca gcttcaccgc acattcaaaa caaattttta 430081 ttctcaattt tatttgacta aaaaagcaat tgattacctg aaaccgggca gcgccatcat 430141 caatacgaca tccatcaacc cgtacgtagg gaacccgaca ctgattgatt atacagcgac 430201 aaaaggggcg atcaatgcct ttacaagaac aatggcgcag gcgcttgtca aagacggcat 430261 ccgtgtaaat gcagtcgcgc cgggtccaat ttggacgcca ctaatcccag ctacgttccc 430321 tgaagaaaca gttgctcaat ttgggcaaga tacgccgatg ggccgtcctg gacagcctgt 430381 tgagcacgtc ggctgttatg tgcttctggc atcagatgag tcctcttaca tgacaggtca 430441 gaccctgcat gtcaacggcg gaaactttgt gacgacataa gagggagtga gacatatggg 430501 catcacgaaa gaagaagtga acagctacta tcaaaaagca gggattgtat taacggacga 430561 ggaagtagac caaatccagc tgatggatta cggcttagga aaagaaagaa aagtcgggct 430621 ccagctcttc gtctacgtca atacagaccg ttattgttca aaggaattgg tgctgtttcc 430681 gggacagact tgcccggaac accgccatcc accggtcgac ggccaggaag gcaagcagga 430741 gaccttccgc tgccgctacg gaaaagtgta tctttacgta gaaggagaaa aaacgccgct 430801 tccaaaagtt ctccctcctc aggaagacag agaacactat acggtctggc acgaaattga 430861 gctagaaccg ggcgggcaat acacgattcc accaaacaca aagcattggt tccaggccgg 430921 ggaagaaggt gccgtcgtga cggaaatgtc atcgacgagc acggataaac atgatatctt 430981 taccgatcca agaatataag gatgggctta acagcccatc ctttttgtat tgaaaaaaac 431041 agaatcatcg ctataatggg taaaaaagga aagagggcga ggcaatgttc acttgcaagg 431101 taaatgagca catcaccatc cgattattgg agccgaagga tgcggagcgg ctggccgaac 431161 tcattatcca aaatcagcag cggcttggca agtggctgtt ttttgcggaa aatccaagca 431221 gcgctgacac gtaccgagaa acaatcattc cagattggcg gcgccagtat gccgacctga 431281 acggcattga ggcgggtctc ctttatgacg gcagcctatg cggcatgatc agcctgcata 431341 accttgatca agtgaatcgt aaggcggaaa tcggatattg gattgccaaa gaatttgaag 431401 ggaaaggcat tattacagct gcctgccgaa aactcattac gtatgctttt gaagagcttg 431461 agctgaatcg tgtggcgatc tgtgcggctg tcggaaacga aaaaagcaga gcggttccgg 431521 agcggatcgg gtttctagag gaaggaaagg cacgggatgg cttatacgta aacggcatgc 431581 atcacgacct cgtctactac agtctgttaa agcgtgaatg ggaaggcgaa aaataaagag 431641 cacactttct tgtttaaatc ttccccggat gtggaaaagt aacagcggag acgttaaaaa 431701 ggagtgattc gagatgaatc agcaagacat taaacaaaaa gtgcttgatg ttctagatca 431761 ccataaagta ggttcgctcg caacagttca aaagggcaaa ccgcattccc gctacatgac 431821 ttttttccat gacgggctga cgatttacac accgacaagc aaggaaactc ataaagcgga 431881 agaaattgag aacaacccca atgtccacat tttattaggc tatgattgtg aaggttttgg 431941 cgacgcatat gtcgaagttg ccggaaaagc aaagatcaac aattcggcag aactcaagga 432001 caaaatatgg agttccaaat tagagcgctg gtttgacggc aaggatgatc cgaatctggt 432061 gattcttgaa attgaaccgg aggatatcag attaatgaat gccggggaga aaacaccggt 432121 ctcactcgaa ctataaaaaa tttgtgtttt caggggcgat atgttattat gaatagctag 432181 taagaaaaat aagcaaataa aaaagaaagt aaacttcttt tttctgtttt gagagagaag 432241 cttaccgctt cccaagcagc ataaccagct gcccttattc ttttccttca taacaaatcg 432301 cccctaacga tgagatggaa aaaagacttt tttgttttac aattcacacc ggcgcggctt 432361 cggagccgca gtgacgattg agaggtaggg ctttcgttgt cttgtgttca agaaatttcc 432421 atggtgttta ctttccagaa tgattcttcg gaacaatgct ttatgaatct aacccgcctg 432481 acttggcgga tgatataatc tttatttgcg tatagaaaag aataagacaa accgcccggc 432541 gtacgccgga cggttttttt attgcaaaaa acacatcgta ctgaaacctc cttgtcttct 432601 ttccagtctt atctctagga tgaaattgga ggaagaataa cgtgcatgtc attacaacac 432661 aagtactttt tattttttgt tttttattgc tgattcactc gatagaaacc ttagcctatg 432721 cgacaaggct ttccggagct cgcgttggat ttattgcgtc cgcgctttct ctgtttaatg 432781 tcatggtcat cgtatccaga atgtcgaata tggtgcagca gccctttact gggcatttaa 432841 ttgatgatgc tggaaaaaac gcactggcga ttgtagggga gcagttccgc tttttaattt 432901 tcggatcgac agtcggcacc attttgggca ttatcctgct cccgtctttt gtcgctcttt 432961 tttcacgggc gattattcac ttggcgggcg gcggcggctc cgtttttcaa gtattccgaa 433021 agggattctc gaaacaagga ttcaaaaatg ccctttccta tttgcgtctg ccgtccattt 433081 catatgtaaa aggatttcat atgcgcttga ttccgaagcg tttgtttgtc atcaacatgc 433141 tgatcacatc gatttatacg attggtgtgc tttcggcttt atacgcaggc cttttggcgc 433201 cggagcgcag cacgacagcc gtcatggctt cgggtttgat caacggaatt gcaacgatgc 433261 tgctggctat ttttgttgat cctaaggtat ccgttcttgc tgatgatgtg gcaaaaggaa 433321 aacgaagcta tatctattta aaatggacct ctgtcacaat ggtcacatca agggtggcgg 433381 gcacactcct cgcccagctc atgtttattc ccggggccta ctatatcgcg tggctgacaa 433441 agtggtttta ataagaaagg ctggatcata aagatccagc ctttttgcgc ttccttattt 433501 atagttcctt aatccgcggt cgtacaaaaa atttccgaat gggacgaaag cggcgatgaa 433561 gccggcagct gaccatttca gcggccattt gacagagaag gttgcataag ccaagacaag 433621 caaatacaaa atgaacaacc cgccgtgaac cgaaccgaca attgtcaccg caagcggaag 433681 gcctgcccaa tatttaagcg gcatagcgat gaacaacagg attaagagtg acattccttc 433741 aataaaaccc atcgtgcgaa gtcttccgat cggcgtgtgc agcataaatc gccctccttg 433801 tggacacgtt ttcattttat actataaaca atccgggggg gcatatgaca gctttcaaaa 433861 aatgttcgga aaacattcat ttttacatgc cttttctagg gaactgtact tgtcatttac 433921 aaaaataccc gagataatgt gtacaaaatc aaaaaagaag gatgttgaaa tgaaacttga 433981 ccagattgat ctgaatatca ttgaggagct gaagaaggac agccgtttgt cgatgaggga 434041 attaggcaga aaaattaagc tgtcgcctcc atctgtaaca gaacgggtaa gacagcttga 434101 atcgtttggc atcatcaagc aatacacgct ggaggtcgac cagaaaaaac tggggcttcc 434161 cgtttcctgc attgtggaag caaccgttaa aaacgcggat tatgagcggt tcaaaagcta 434221 tattcaaaca ttgccgaata ttgaattttg ctaccggatt gcgggtgcag cctgctatat 434281 gctgaaaatc aatgccgaaa gcctcgaagc ggtagaagat ttcattaaca aaacatcgcc 434341 ctacgcgcaa accgtcactc acgtcatttt ctcagaaatt gacacgaaaa acgggcgcgg 434401 ttagagagtg ccgcgcgaag tctgttataa taacaggatg agcgtgaaag aaagagaagt 434461 gatcaagcat gtcaaaaaca gttgtattag ctgaaaaacc ttcagtcggc cgggatttag 434521 cccgggtact gaagtgccat aaaaaaggaa acggttatct cgaaggcgat caatatattg 434581 tgacttgggc tttaggccat ttggtgacgc ttgctgatcc ggaaggctac ggaaaagaat 434641 ttcaatcatg gcgcctagag gatctgccga ttatcccaga acccttgaag cttgtggtga 434701 taaaaaaaac cggaaagcag ttcaatgcag tcaaatccca gcttacccgt aaagacgtca 434761 atcagattgt catcgcgact gacgcaggcc gggaaggtga gcttgttgcg cgctggatca 434821 ttgagaaagc gaatgtccga aaaccaatca agcggctgtg gatttcatct gtgacggata 434881 aagcgatcaa ggaaggtttt caaaagctgc gcagcggcaa agaatatgaa aacctgtacc 434941 attctgccgt cgccagagcg gaagcggatt ggattgtggg gatcaacgcc acccgtgcac 435001 ttaccacaaa attcaatgcc cagctctcat gcgggcgtgt gcagactccg acgcttgcca 435061 tgattgcaaa gcgcgaggca gacattcagg cgtttacgcc cgttccgtat tacggcatac 435121 gtgctgcagt cgacggcatg acgctgacgt ggcaggataa gaaatcaaag cagacgagaa 435181 cgttcaatca agatgtaaca agccgtttgc taaaaaatct ccaaggaaag caagcggtcg 435241 tagctgagct gaaaaaaaca gcgaaaaaaa gctttgcgcc tgcgctttat gatttaacgg 435301 agctccagcg tgacgcccac aagcgcttcg gtttttctgc caaagaaacg ctttctgtcc 435361 tgcagaagct atatgagcag cataagctcg tcacatatcc gcggacggac tctagatttt 435421 tatccagtga catcgtcccg acgttaaaag accgtctgga aggcatggaa gtaaaaccgt 435481 atgcccaata tgtcagccaa attaaaaaac gcggcattaa atctcataaa ggatatgtca 435541 atgacgcgaa ggtgtcagac caccacgcga ttatcccgac cgaagagccg ctcgttctca 435601 gcagtctgag tgataaagaa cgaaagctgt atgacctgat tgcgaaacgt ttcctggctg 435661 tattaatgcc tgcattcgaa tatgaggaaa caaaggtcat cgcagaaatc ggcggagaaa 435721 cctttacggc gaaaggcaaa accgtgcagt cgcaagggtg gaaagccgtt tatgatatgg 435781 cggaagagga tgatgagcag gaggatgaca gagatcagac acttcctgcg cttcaaaaag 435841 gcgacacact tgccgtccgc acgttaacgg aaacaagcgg ccaaacgaag ccgcctgccc 435901 gctttaatga agggaccttg ctgtcagcga tggaaaaccc aagcgcgttt atgcagggag 435961 aagaaaaagg cctcgtcaaa acgcttggag aaacaggcgg cctcggcacg gtggcaacgc 436021 gtgccgacat tattgaaaaa ctgttcaaca gctttttaat cgagaaaaaa ggccaagata 436081 tttttatcac atctaaagga aaacagctcc tgcagcttgt tccggaggat ctgaaatcac 436141 cggccttaac agcagaatgg gagcaaaagc tgtctgcgat cgcggccggc aaattgaaat 436201 cggctgtttt tattaaagat atgaaggctt acgctcacca aacggtaaaa gaaatcaaaa 436261 acagcagcca aaccttccga catgacaaca ttacgggaac ggcatgtccg gaatgcggca 436321 aaatgatgct gaaagtaaac ggcaaacgcg ggacgatgct cgtgtgccaa gatcgtgaat 436381 gcggaagcag aaaaacgatt gcccgaaaaa caaacgcacg ctgcccaaat tgccataaaa 436441 gaatggagct tcgcggccaa ggcgagggcc aaacctttgc gtgtgtgtgc ggtcaccgtg 436501 aaaagctctc tgtatttgaa aaacgaaaaa acaaagacaa agcgcgtgct accaaacggg 436561 acgtatcctc ttatatgaaa aaacaaaata aagatgagcc gattaacaac gcgctggcag 436621 aacagctgaa aaaactcggt ttggataaat aataaaaaaa cctgtgccta tcgcacaggt 436681 tttttattgg acttaggtcc tgttttctta atgttcaaaa agggaaaaaa aagctagcaa 436741 tctgcatttt ttttctttta tagtaaatgt actttgtaac atggcagtca tattttcgtc 436801 tataactatt tgtgagcgtc tgatttgctt caggcgacaa agggggattt gcctgtgagg 436861 catgtactaa ttgctgtcat cttattcttc ttatctatcg gactttccgc agggtgtgct 436921 gaagctggaa acaagaccca aaatcagtcg gcgacagaag tgaatgccag cccgctccag 436981 ccggcggaat atttcatcta tcacaattta atgaatgaca aagggctgat caaaaccgat 437041 ttttcagacc agccttctta cttgtcggaa tctctcggac tgtggatgga gtttctgctc 437101 agcaaaaatg acgcaccaca tttccaggat caatatcagc atctgactga ttcatttctg 437161 atgagcaatc acttggtgac gtggaagatt caaaatggcc aagcgagcgg gacgaatgcg 437221 ctgatagatg atatgagaat tatgctgtct cttgaccaag ccgccgcaaa atggggccgc 437281 agcgactacg cgcaaacggc tagggatatc ggcacgtctt tgaagacata caatatgaac 437341 aacgggtttt ttacagactt ttacgactca caggccgctt caaaggatgt gacgctttca 437401 tacgtcatgc ctgatgcctt agctgtctta aagaagaatg gaatcataga cgaagaaaca 437461 gaacagcgga atgccaatgt tctctattca gctcctttaa aaaatggctt tctgccgaag 437521 acatacagct cggagacgaa ggaatacaca tatgatagtg aaatcaacct gattgatcag 437581 ctttacgctg cttggcattt gccggaaggg gatgaaaaag catctgtttt agcggactgg 437641 atcaagcagg aatttcagaa aaacggaaag ctgtacgggc ggtattcggc atatacgaag 437701 gagcctgccg tccaatatga gtctccatcc gtatatgcct tagccgtatt gtttttgaca 437761 aaacagcatg aaaacagttc tgtcatcaaa gccatatatg atagaatgaa tgactttgaa 437821 attcatgatc cggtgaaatc gtattatgga ggctatatga gcggcactca gacgcattca 437881 tttgacaatc tgctgccgct gttagccgaa aggaagcttt ttaatgaaaa tatcattcag 437941 tgaatcacaa aaattatttg cttatttttc agggctcatc gcggccctgt ctttgtttat 438001 ttattatgtg tcagcccagc aatcagaagg tgctctgatc ctttgcatca catttggcgt 438061 catcgccgca ggcatctggt tcggcccgat ttacgcgctg gcagtgacct taatcgtact 438121 ctttgttctc ggcaccttaa tgatgttttt ccagactgga cagacatcgc tctttccggc 438181 tgaggaaggg ctgcgaatgc ttgtcgtgtg gggaatcgcg cttttgctgt tttcttttat 438241 ttctggaaga atccacgata ttacagcaga gcttcggcgc tcaatgacac ggcttcaatc 438301 cgaaattaaa agctatgttg ctgttgacag agtgactggt tttgataaca agcaaaggat 438361 gaagctggaa ctttcagaag aaatcaagcg ggcggagcgc tacggcaatt cttttgtgtt 438421 tttgctgctc catatgcatt atttcaaaga gtttaagtct ttgtacggtg aaaaagaaac 438481 ggaccgcctc ttccaatatg tcggtcagca aatcaggaca agcgttcggg aaacggataa 438541 gaaattccgt ccctctgacg agcgtatcgg gatcgtgctg acgcacacgc ctgctgaaca 438601 tatgccggcc gttctgacta agctgaagaa acaattggat acatatcagc tggaaaatgg 438661 aaagtatgtg tcgcttacgt tccacgtttg ctatttgccc taccgcaacg atatccaaac 438721 agctgatcaa tttttagaag aactggaaaa cgagatgatg atgaatgaac tataaaggaa 438781 tcacattgct atgcgtcatg atgcttctat tttcagctat tgcgtctttt cccgtttctg 438841 cgcaagcgaa agatcaggat gccggcattc tcatcatcta ctcaaccttg gacggcaaag 438901 agtcgtcaca agtcaaaatg ctcgatttgc ttgcgggcca ctttacatcc catgtgacag 438961 tcaaaaaaga ttcagacgtt gaagcgtcgg atttcaaagg gaaagaccat gtgatttatt 439021 acggccaaac gaaaagaaag ctcagccaaa aattgctgtc tcttatcagc ggcgtgaaaa 439081 aaccggttgt cgccattggc tataacgcag gccaaatcag ccaattttct gggctttcat 439141 tagcccgcaa agaaaatgtg tttcaggttc acagcaggtc agaaaaggcc gatgtgtctc 439201 tggaaagcgg gcttaacgtg ctgagtgtat caggcctgaa aggaacggcg ctttacacct 439261 tcaaagcgga tgaaggcaca acgcattctt ttatatggaa aacaaaaaaa gggaatgtgt 439321 acattggatt aacaaatttg ttaaatgaca atttgatcgt ggcgaaacag ctcagagaag 439381 ctttcggaga gaaggcgggg acgacgttat tgtatttgcg tctcgaggat atcagcccga 439441 tgtctgatga aaaactgctg cttcaagccg gtacatacct gcataagcgg catattcctt 439501 ttatcctggc ggtcattccg gtttacttga atccggaaac aggcgacaaa gtgtatttgt 439561 ctaatcaacc gaagatggtc aaggtgctga agaagctgca aagcatgggc ggcagtatca 439621 tagttcacgg ctatactcac gcttatcgct acagtgaaac aggagaggga tttgaatttt 439681 gggatgcaaa ggcggatcag ccgattacat ccggaaatgc cgaagacccc ccgtccattt 439741 tggagaaaga acaggacttc ccgaacgaac aagcctatca cagctatctt gaaccatttc 439801 gggaaaagga agaaacgtat acaaaacaaa aactgacgcg tgccattgag gatttgacat 439861 catcgggtct ttacccgctg gcgtttgaag cgccgcatta cacgatgtcc gaatatggct 439921 atcaaatcgc ctcgcagtat tttacaagca ttttcggcca ggtccagctc agcagcacaa 439981 catggaaaac atccggtgca cctccgtttg tgactgctcc ttcgatgctg cacggaatga 440041 cgctttatcc ggaaacgatc ggctttgtcg acacatcgaa gcaaaacccg ctcggtgaga 440101 tggaggagca tatctcccag atgattgatt ttgaaggcgg agtagccgga ggattttatc 440161 acccgtacct tgggatgaaa tatctgcctg agctggttga tcagatggaa cgcattccag 440221 acagtgaatg gcttgattta aagaaaacga aacaaaccgt caaaacagac aaagtggaaa 440281 ttcatacaag cggtgacgga acgattcagg tgaaaaacgg cgtaagcccc atttacgagt 440341 ttttcgatca tcaccggcaa acccctctgg aaaaggcgtt atggattctc tccgctgttg 440401 tgctcttatt tgtcatcatg tttgtcagtt atacgtttta cttgagagcc acattgaaaa 440461 aacgaatttt taaggagaga agaagccttg ggtaatacgc tgttctttat ctcgctaagt 440521 ttaatatggg ttatgcttct ctaccacatg ttcctcatgc agggcgggtt tcgccactat 440581 atgaccttcg aacggaatat cccgaagtgg agagaaaata tgaaggaact gccgaaggtc 440641 agcgtcctca tcccggcgca taacgaagag gttgtgattc ggcagacgct gaaggccatg 440701 gtcaaccttt attatccgaa ggaccggctg gagattatcg tcgttaatga taattcatca 440761 gaccggacgg gtgatatcgt caatgaattt tccgagaaat acgatttcat caaaatggtg 440821 attacgaagc cgccaaatgc aggaaaagga aaatcctctg cacttaactc gggttttgcc 440881 gaatcgaacg gcgatgtgat ctgtgtgtat gacgccgaca acacgcctga gaaaatggcc 440941 gtgtattacc tcgtgctcgg cctgatgaat gacgaaaagg caggcgccgt ggtagggaaa 441001 ttccgcgtca tcaatgcggc aaagacgctg ctgacgaggt ttattaatat cgaaacgatc 441061 tgttttcagt ggatggccca gggaggcaga tggaagtggt tcaaaatcgc cacgatccca 441121 ggcaccaact tcgcgatccg cagaagcatt atcgaaaagc tcggaggctg ggatgacaaa 441181 gcgctcgctg aggatactga gctgaccatc cgggtatata atctcggcta tcacatccgc 441241 tttttccctg ccgccatcac gtgggagcag gaaccggaaa catggaaggt atggtggcgc 441301 cagcgcaccc gatgggcgcg cggcaatcaa tatgtcgtgc tcaaattttt ggcgcagttt 441361 tttaagctga aacgaaaacg gattatcttt gatttgtttt attttttctt tacgtacttc 441421 ctgtttttct ttggcgtgat catgtcaaat gcgatttttg tagtgaattt gttttatgat 441481 ttgcatttgt ctgttggatt tttggcaatg attctctgga ttttggcgtt tttcttattt 441541 atgacagagg tcatgattac gttgagcatt gaaaaaacag aaatgaacaa gcaaaacttt 441601 tttatcgtat ttctcatgta cttcacatac tcgcaggcat ggattgtgct tgttatctac 441661 tctttattcg tagaaatcaa gcaccgttta ttcaagcaag aggtcaaatg gtacaagaca 441721 gaacgataca atcaacataa aagcgggtga cctttttgaa acaaataatg atttttctca 441781 caagcttcat gctgctggcg atgactggac aaacggctct tgccaaagac gtacaggtca 441841 gcggttcgct ccttgggaaa agcagccaag aacaagccaa acagcaggtg ctgacaagcg 441901 agctgattac actgtatgga tcaaaagaca gcgcagagct gacgtatcag atcccggcag 441961 gcgcctcttc gggcaatcag caattggtaa tcgaatacga ggcatcaaat cttttaattt 442021 ctccatcatc gttaacggtt gtcattgatg atgaaccggt caagacgtta aagcttgatg 442081 gtgattccaa acggaaaaca gtgaagctga atctgaataa aagccagtct gcgcaaggct 442141 atcacaacgt atcgctgaaa ttctacggcg taatgaaaga gggcgtgtgc gtcagacagg 442201 atacatcagg caactggatc aaaatttatc cggacagccg gctgacactt gctgacagca 442261 gtgaagcgaa gggaacgtcg ctggaccatt atccgtatcc tttcgcccaa tctggaaata 442321 cagcggaaga aacagctatc gtcattccgg ataacccaag ttcagcagaa atagaagctg 442381 ctgttaaaac agaaggctat ttgaaaacgg tggacagcag tgtcagtatt gcgtatgtca 442441 cggaatctga actgaaaaaa atcgataagc cgacgattgt tatcggcgtg gacaagcatt 442501 ggaacggcaa agtgaaaaaa ctgttgaaac aagccgggct acaggcaaaa ggagaaaacc 442561 ttctgcttgc ggagcgggtg ctgaaagcag agggcaaaca gcagccggtt ctgtttgcgc 442621 aagcggcgtc cgaggacgcg ctcacaaaaa aaatcagcgt gatgacagat cagacatata 442681 caggccagct cagcggcgat acactttcaa tcagcaagct tcagcagact gaaaaaaaag 442741 aaagcgataa gctgaccctt gagaattttg gagcgggtga tatcacaatt ggagccgaca 442801 aaacatcttc agcacattat ttttatccgg cttcggctgt tttagatgaa aaccaatcgg 442861 cgaagctgtc gcttaaactg aaaaagtctg aaacgattca agcctcaacg gctgaaaacg 442921 agtcagcctc tcaggctgca gaactgaaag tgatgatcaa cggccagccg cactcggtcc 442981 ggcttgatga attaggaaaa gaagataaaa acggattcta tcatgtcaca gtgaaagtgg 443041 accctaagct gctgcaaaaa aaccgctaca ttgatattca gttcgtcacg accggtttaa 443101 aggaaaacaa cccttgtaac accactgatg aagaaaagtg ggtttttatc gataaaaaca 443161 gtacattatc atacgccatc aaaggcatgt ccccgtcagc ggattttcaa gagtggccgc 443221 tgccttacgc cggaaaccag gatcaaacaa cgttaatcgt gcttcctgac accgtaagcc 443281 aatcgaagct agaggagctt tctctcgtaa cagaatcctt tggcaacgaa gcacagcatt 443341 catatacggt aaagaaatca tctgacgtta cagcaaatga tgcgaaagga cgaaacctca 443401 ttttcatagg agggatcaat caattttctc ttctgaagga gaaatcatca gatctgcttg 443461 tgccgcagga aaagaacggc tcgtttgatg tatctagttt cgagatgctg aatgagacga 443521 caaaacaagt ggtatttacc caagcatcgg tttgggattc acgctataca atggctgtct 443581 ttgcaccgtc aaaaggagat ggcacggctg tcacaaaaga gatcatcagt tatctgaaca 443641 gcaacgatga gtcggcaacc gtccttaatg aaacaaacag ccagcaggtg tttacaaacc 443701 accagcagct caaatcggaa acaaacagtt ccgatgcaga acaaccaaca caggatcata 443761 gccagaaatg gatgtatatt ggtgtgctgg cactcattat ggtggttgcg gcagtgttca 443821 tttggattgc cgtaagacgc aaaaaaagaa agacagatac agaataaaac agaggcgatt 443881 ttagcctctg tttttttatt tttggtaagt aaattccatt tgtggaacct gtcattttat 443941 ttttttctct cagccaataa gcctctttac aacgtgcggg aacgggagta tgatctcttt 444001 tagaaaacaa atcgcttaat ctgaaatcag agcgggggac ccaatagaac ggctttttgc 444061 cgttggggtg aatccttttt aggtagggct aactctcata tgcccgaatc cgtcagctaa 444121 cctcgtaagc gttcgtgaga ggagatgaat gaaacctgtg ttcgatgtta tggcacaggg 444181 gcatccgttt gcctctgtgt tttttgttgt tcatttttga atgcaaatcg catacagaga 444241 catcatagca gaaaggacta tcatcaacat gtgagagcaa gacactgatg gatgttttat 444301 tgttttaatt gaaaaatgag aaattaaaag gggaagacat cgatgtatca ttcaatcaaa 444361 cgttttttga ttgggaaacc actaaaatcc caagcagctg gagagcaaaa actgacgaaa 444421 ttaaaagcct tggctatgct ttcctcagat gcgctgtcat ctgtcgcata tgggacagaa 444481 caaattctaa tcattttggc aacaatcagt gcagccgcat tttggtactc cattccgatt 444541 gcggttggcg ttctcatctt gctgctcgca ctgattcttt catacaggca aattatttac 444601 gcttatccgc agggcggcgg ggcgtatatc gtttctaaag aaaatctcgg tgaaaaaccg 444661 ggattgattg cgggcggttc attgcttgtt gattatattt taacagtagc ggtaagtatt 444721 tccgcaggca cggatgccat cacgtcagcc tttcctgcat tgcatgatta tcatgtgccg 444781 atcgctattt ttctcgtgtt agtgattatg attttgaacc tgcgcgggct ttcggaatca 444841 gcatccatac ttgcctaccc ggtttatctg tttgtggtgg cgcttttggt tctcattgca 444901 gtcgggttgt ttaaacttat gacaggacaa atagaccagc cagcccatca tacatcgctc 444961 ggcacacctg tagccggcat tacgctattt ttgctgctta aggctttttc ctccggatgc 445021 tcagcgttga ccggggttga ggccatttct aatgcgattc ctgcattcaa aaacccgcct 445081 gcgcgaaacg cggcaagaac gcttgcgatg atggggattt tgctggcgat tctgttttcc 445141 ggcatcacgg ttctcgcgta cgggtatggt acggcgccga aacctgatga aacagtggtt 445201 tcacaaattg cgtccgaaac ctttgggcgg aatgtgttct actatgtcat ccaaggtgtc 445261 acatcgctta ttttggttct tgcggcaaat acgggattct cagccttccc gcagcttgcc 445321 ttcaacctgg cgagagacca gtatatgccg cgaatgttta cagtcagggg cgaccgctta 445381 ggcttctcaa atgggattat ctttttaggc tttgcctcca ttgttctcat tatcttattc 445441 gggggacaga cggagcactt aatcccgtta tatgctgtgg gcgtatttat tccatttacg 445501 ctttcacaaa ccggcatgtg catgaaatgg atcaagcaaa aaccaaaagg ctggatcgga 445561 aaaatgctga tcaactcctg cggcgctctg atatcattta tggttctatc cattctgttt 445621 gtgacgaagt ttaatgtcgt atggcctgtg ttaatcttta tgcctatcgt cgttttgctg 445681 ttttttgcga ttaaaaatca ctatactgcg gttggtgaac agcttcgcat cgtagacaaa 445741 gagccggaag aaatcaaagg caccgttgtg attgtgcctg tggccggtgt caccaccgtc 445801 gtgcaaaaat cgattcacta tgcgaaatca ctgtccgatc aggtgatcgc cgttcacgtg 445861 tcatttgaca gagaacagga aaagaaattc gaaaaacgtt gggaagagct taataacgga 445921 gtgcgtctcg tgacgcttca ctcctcttac agaagccttg tccatccgtt tgataagttt 445981 ttggaaacag ttgaggcaaa agcgaagaag gagcagtttt ccgttatggt gctgtttccg 446041 caatttataa cgaaaaaacg ctggcacacc atccttcaca accaatcggc cttcctcctc 446101 agagtccggc tgttctggaa aaaggacata atggttgcca cactgccgta tcattttaaa 446161 aagtaaagct ctaggaccaa gggaatcacc ttggtccttt ttagcgggaa aaggaggtat 446221 gggggtgtat acacaaggtg cttttgtgat cgtattgaac gaaagtcagc aaattctgct 446281 ggtgaaacga aaagatgtcc ctctatggga tttgccgggc ggcagggttg atcccgggga 446341 atcggctgag gaagcggcag tgcgggagat attggaagaa acgggataca atgcagcgct 446401 ttctgcgaaa ataggtgttt accaaaggcc aaagtttcaa gatgaacagc atctgttttt 446461 cggaagcatt acaggcggac aagcaatggc tgacggcaca gagacagcgg gattaaagtg 446521 ggtttccccg gggcgtttgc cgctttttat ggtgccgaat cgaaaaaggc agatcaatga 446581 tttcaagaac ggcgctcaag atgtaaatgt caccgtcaag gatagcgggt tgctcgcggc 446641 gatcgacctg ttgaaaagaa gactgggcaa gtgattcagg tctccgggtt ttaaagcctt 446701 tctcctgtgg tattgaaaaa aggaaaaagg aggatacgtt atggcacaca aaactgcagg 446761 acaagcaatg acagagctgc ttgagcaatg gggagttgat catgtatacg gcatccccgg 446821 agacagtata aatgagttta tcgaagaatt aagacacgaa agaaatcaac tgaagttcat 446881 tcaaacccgc cacgaagagg tagcggcact ggcagccgcg gctgaagcaa aactcaccgg 446941 caagatcgga gtctgtctgt caatcgcagg gccgggagcg gtgcacttat taaatggttt 447001 atatgatgct aaagccgacg gcgcccctgt gctggcgatt gcaggacagg tttcttctgg 447061 cgaagtcgga cgggactatt tccaggagat taagctggag caaatgtttg aggacgtggc 447121 cgtgttcaac agagaggtac atagcgcgga atcacttccg gatctcttaa atcaggcgat 447181 caggaccgcc tacagcaaaa aaggcgttgc ggtattgagc gtgtcagatg atttgtttgc 447241 ggagaaaatc aaacgggagc ccgtgtatac ttcaccggtg tatattgaag ggaacctaga 447301 accgaaaaaa gaacagctcg tcacctgcgc ccaatatatt aataacgcta agaaaccgat 447361 tatcctggca gggcagggaa tgaaaaaggc gaaacgggag ctcttagaat ttgcggacaa 447421 agccgccgct ccgatcgttg ttacactccc ggcaaagggt gttgttcccg ataagcaccc 447481 acattttctc ggcaacctcg gtcagatcgg aacaaagccg gcttacgagg caatggagga 447541 atgtgattta ttaatcatgc tcggaacgtc attcccgtac cgtgattatt tgcctgatga 447601 cacgccggcg atacagctcg attcagaccc ggcaaaaatc ggaaaacggt atccggtgac 447661 agcgggcctt gtctgtgatt cggctctcgg tttgcgcgaa ttgacagagt atattgaacg 447721 caaggaagac agaagattcc tgaatgcctg cacagaacat atgcagcatt ggtggaacga 447781 aattgaaaaa gatgagacag aggcaacaac accgcttaaa cctcagcagg tcgtggcccg 447841 tcttcaggaa gcggcagccg atgatgcggt gctctctgta gatgtcggca ctgtgacagt 447901 ctggatggcg cgtcatttca aaatgaacgc gaatcaggat ttcatcgttt ccagctggct 447961 tgcgacaatg ggctgcggcc tgccgggagc gattgcagcg agcttgtccg aaccggaacg 448021 ccaggcgatc gccgtctgcg gtgacggggg attttccatg gtcatgcagg accttccgac 448081 cgccgttaaa tataagctcc cgatcacagt cgttatttta aacaacgaaa atctcggcat 448141 gattgagtac gagcagcagg tcaaaggcaa tatcgactat gtcacaaaac ttcaaaatgt 448201 cgactatgcc gcatttgcag aaagctgcgg agcaaagggc atcaaagtga ccaaagcgga 448261 agagcttgcg ccggcttttc atgaggcgct gcactctgac caaccggtcg tagtggatgt 448321 catgattgga aacgaaccgc cgcttcctgg caaaatcacc tacgggcagg cgaaaggctt 448381 tagcaagtac atgctgaaaa acttcttcga aaaccaaaaa tttgaaatgc cgtcactgaa 448441 gaaaagtttg aaacggttat tttaaaaaaa caggggccct aagagccctt gttttttttt 448501 ttttttttgg aaacaaatgt attttcagca tgtttgaatt cataaaatga tcggtatatg 448561 tattaggaac tgatttcgcc atactcgaaa cagacaaaag gacaaatgca tcttgtttca 448621 aaggaagatg catttgtcct tgcatgctta ttcttatcaa atcttacaga actcttctca 448681 taataggtta tttttctttt ttcttcagcc cgaagaagaa aggaaaagca gaaccgacca 448741 agaaggtgcc gaataaaaac atgccgccga taaacacgtg gaaatttgtg tgtccggccg 448801 taaacgccgt gattagggaa atgatactga gcacgatcat ggcaatgccg ggcgcgactc 448861 tcatttttcc cttggattta tgggcagcaa cagaacataa aatgccgata acaataggaa 448921 caatccacaa ataaaacaga ataaatactg acatcatcaa aactccgatt tttcttctat 448981 cataacaaat ttctgtcaaa aagggtatca atgagctttt gcggaaaaat aaaaaccggc 449041 tttagaagcc ggttttttta tcgaaacgta tctacaatta aaaacacatt caaagcaacg 449101 atcaatacag caatcagcca agacaccact gtgatccatt tggcgttgat cagagatccc 449161 atgatccgtt tattgcttgt aaacataata agcggaatga gggcaaaggc gatcccgaag 449221 gacagcacga cctggctcag tacgagagcg gtcgtcggat taacacctga cgcgatgatc 449281 aagatcggcg gaatgatcgt gataaaacgc cgtacataca gcggaatgcg gtagttgata 449341 aatccttgca taatcacgtc gcctgaaagt gtgccgacag acgaactgga tagaccggca 449401 acgagcagcc cgatcccgaa caaagccgca gacatagggc tgacaagatg tccgaattgc 449461 tgaaatgcga cgtcgagatc ctcaacaaac aggccgtttt tgaagaataa tgcggcagcc 449521 acaatcagca tacttgcatt aatagcccct gcaatcagca tcgctattaa aatatcaata 449581 aattcaaacc taaagatttt tttccgttct gcatcagttt tgccaaccac ccgccgctgt 449641 gtaagggcag agtgtaaata aatggcgtgc ggcataacag ttgcgccaag aatacccgct 449701 gcaagaagca cactgtcggt gccatgaaac gccgggacaa aaaggccctt catcactgac 449761 acggcatcag gctttgcgaa aaaggtctgc aacgcaaagg cgatcacgac cacaaacagc 449821 ataccggcaa tacctgcttc aagtgagcga taaccacggc gctgaagctc caatatcgcg 449881 aaagaaccga tcgccgcaat aatagacgct tcaagcatcg gaatgccgaa cagcaaatac 449941 agtcccagag ccgctccgat aaattccgcc agatcagttg cgataatgac caactcgccc 450001 tgaatccata atccgatcga gacaggcttc gggaattctt cacgggcaac ctcaggcaga 450061 tttttgcctg tcgcaatacc gagtttggcg gatagggatt gaattaaaag cgccatgata 450121 ttggaaaata agatcaccca taagagcata tatccgtatt tagaacccgc cgaaatattc 450181 gttgcgaagt tgccgggatc aatataggca atggctgcta taaatgcagg gccgagaaaa 450241 gggagcagcc ctctgaatcc tctgattttc ccgtcaagcg catcttggac ggctttggaa 450301 cggggagatt gtgctgtgat gtccttgttc atcatgtctc acctgaattc tgtttgtttt 450361 tgccgtacaa caaagagttt ccttaaggca aattatttta tctacatcat atgaccatcc 450421 cggtttcttg tcaaccgaaa atgttcaaaa tacacttctg aatttttccc tgttatgtaa 450481 catgatatgt agggattcgt gataaggtcc catataaaaa gacatcgttt catttcgaaa 450541 cgatgcctcc tgtatctaat gagtctaggc ttccttccgc agcccgcgga atataaggcc 450601 cagcaagaac acgaagatgg ctgccccgat gatggccggg aaaatagcaa agccggcgag 450661 gctcggtccc catgtgccaa gaagtccgtg cccaatccaa gcgccgatca gcccggcaat 450721 catagagccg aaaattcctc ccggcagccg gtttcctaca atggcgctcc caattaatcc 450781 gataacaatt gcaacaacta atgaaaccaa aaagctaagc atcatgatca cctctcataa 450841 atgatttacc aatcaataac cgctcctgat catttcgaaa cacttgaaag catattcctt 450901 tatgatcctg ttttaatctt tctctgcaca ctgccgtcag ctaaatgaac aatgacctca 450961 gtgcctttat gcgccgcgat ttcctttgcc cgttcaatcg cttctttctt tgtatccttg 451021 atttcagaca cacgtttggc gccctcggct ttgactgccc agcctttttt atgcttaata 451081 acatgctctg ctttattcat gagctcgggg ccgctgccgc tgcttggatc agcatcgcgt 451141 tctgtctcat catcatgcgt caggaaatca tcaatttcat ctgtagaggc gttttccgcc 451201 cattccttcg ctttgcttgt cgcaattgga atcgcgcgcc cttcctcata gccttcatca 451261 atcatcgcat tcgcaatgtc tatcgccttt tttctcaccg gcttctcaag attttttaat 451321 gaagcaggat aatccttcat cgaccaaggc atgtctatca ctccttttcc ttttataaaa 451381 atggtacccg caggtgaaaa ataaaaacgc atccgaaaaa atgaaggtat actatatagt 451441 agaaaaaacg gaagggaagt gcgggttggg tgccaacaga acgaaaagaa gacttacatc 451501 agcaattaaa agagatagag aaatgggaaa aagatcagca aaaagtctgg ttttgggaaa 451561 agctcagccg tctcccgttt caactcctgg acaagctgac accagaattc atccagaaaa 451621 agatcggcaa gctcttggat gaggtcggca gctttgttca aacaggcgga cagtacctga 451681 catctgaaaa acagattatc aggatgtttc aaaagaaact gccggaggag atctttgaat 451741 cgctggagga catccggaaa gcgcctcttc ctgtcatgga tgaaattgcg gaaggaatgg 451801 gcaaaaacag aaccaacgca gcaaccgttc aaggcgcgac aaccggtgtg ggcggcgtgt 451861 ttacgctggc ggcagacatt ccggcagtgc ttggcttatc actaaaaaca ttacaggata 451921 tcgcagtcgc atacggctat gacccaaagg agaaaaaaga acgagtcttc attgtgaaat 451981 gcctgcagct tacgtcggct gatgttgtcg gcaaaagatc gattttgcag gaattaaaac 452041 actacgatca agaccgtaca tataagaatg tcgcttctca aatccaaggc tggcgagaag 452101 tcgttttggg ctatcgagac acgtttggct ggaaaaaact tttccagata gtgccggttg 452161 ccggaatggt ttttggcgcc gctgccaatc gctcaacatt aaacgacatt accgagacag 452221 gcatgatgct gtacaaaaag aggcgcattc ttgaacgact gaaagaaaca gaacgagaga 452281 tggaatagca gaaagcagac ggacaccgcg atccgcctgc tttttttagt ggaaacatac 452341 ccaatgtgtt ttgtttgttt aaaagaattg tgagcgggaa tacaacaacc aacaccaatt 452401 aaaggaggaa ttcaaaatgg cagacaataa caaaatgagc agagaagaag caggtagaaa 452461 aggcggagaa acaacaagca agaaccatga caaagaattc tatcaagaga ttggtcaaaa 452521 aggcggagaa gccactagca aaaaccatga caaagaattc tatcaggaaa tcggcgaaaa 452581 aggcggagaa gccactagca agaaccatga caaagagttc tatcaagaaa tcggtgaaaa 452641 aggcggagaa gccactagcg aaaatcatga caaagaattc tatcaagaaa tcggccgaaa 452701 aggcggagag gcaacaagca aaaatcatga taaagaattc taccaagaaa ttggctcaaa 452761 aggcggaaac gcccgcaaca acgactaatc aaaagcataa aggcagacaa cctgtaaata 452821 aaaaagcgat ccggcacatc agctggatcg cttttttttg gaatcttctc aatttatgcc 452881 gctattgaga tacaataagt gaaaaagggg ttttcgctaa tgtccaagat gcaaaacttg 452941 ctcgccatcg caaatgaagt caaagaaaag cacgccaatt tttcaatctc agaggtcaac 453001 gaccactgcg tgcgccttgc ggtgtttacg ggagaatatg actggcacca tcaccctgac 453061 tcagacgaat tgtttattgt tcttgaaggg gagctgctga tcgattttaa ggacaaagaa 453121 accgcggtgc tcaaagcaaa tgacagcctg ctgatcccta aaggcacggt tcaccgcaca 453181 cgctcttacg tcagaacggt aaatctctgt gtggagcata aacaagccga aaccgtcatc 453241 atagaggagc agccatgcta atcaaaaaga tgatatgtga agtagatgct gcaaacgctg 453301 aagcatttgc aaaagcgcag tcacagtggg aagcgttatc gcatataagc ggctttatca 453361 aacaggccgg cggctggcga aaaacgatag acgagccgct caccgcagaa atcatcagtg 453421 tatgggaaaa cagagaagcc tatgatcatt ttatggagaa cgaacatgac agcatatacg 453481 aggaaaacga tcagaaggct gtaattcttt cgatagaggt gacggtgtac gaagaggata 453541 aaccgttcgt tcacgatctg ttacataacc ccgatatccg gtacgaacca aactggacgg 453601 ttctgaaggc ataatcaaag cccaaaacat catgttttgg gcttgtctct ttactcgcgt 453661 cccggaagtg tattatgaac aaaaggcggt gctggtttta actccggttt ttctccaaac 453721 gtttttgctt ctttcacata ttcaaaggct tctccgtccg gcgctttttc attcagccag 453781 ttttgctcgg cgcttacttc gccttcagag aaattgataa gctgatgtga gaactcttgt 453841 ttttcgagcg ctttcgggaa tgtacccggc acaaccggac cttcctgtgc ttctaattct 453901 ttaatggcgg cgagccattg gttctggtgc atcgtgtcac gcgccagcag gaagctgagc 453961 atatctttga cgcctttgtc atccgtcatt tcaaacaggc gtgcgacctg cagacggccc 454021 tgagattccg cattcaggtt ggcgcggaag tctgccagca ggtttccgct tgctacgata 454081 taaccgccgc tccaaggtac gcctgtactg ctttccggca tggcgccaag tcctgataca 454141 atcgcatggt gagggttcat gccgcctagg atggagccga tgaccggatc ttcagcagct 454201 ttttcctgct gatcaagagg ggcatcctca agaagtctgg caatcatcgt tgcgatcatt 454261 tcaacatgcc cgagctcctc agttgccgta tccatcagca agtccttgta tttttcattt 454321 cctcttgtgt tccagccttg aaataagtac tgcatggcaa ctgaaatttc tccgaattgc 454381 ccgcctaaaa tttcttgcat ttttttagcg aataatggat ctggacgatc tggtttagca 454441 ggatgctgca gcatttttgt gtgcttaaac atgtacccat ctcctttttc gtttatctct 454501 ttttatattt ccgatcgata gaaagataaa cgaaaaacag cgtatcgaga tgggaactat 454561 gaatcttttc gcagctccaa cagttcccgg atcagctccc ggccaaagat gggctcatac 454621 tgccggtaaa cagggtcaag acgcttcatc cattcttgtt tctctttatc tgacagctca 454681 taaatatgta tagcagaatt ctttttgatt tcttccagct gctccttgtt catttgttcg 454741 gcatacgttt cattccactc cgttgtctcc ttcatcgctt cagtcaaaat gcgtcttgtt 454801 tctggtgttt gcgccttcca gaagtgttca tcagtcatga cagcgtagcc gagataaccg 454861 tggctgctta ttgtcaaata gtcctgaaca ttataaaatt ttttagaata gatgtttgaa 454921 attgtatttt cttcgccatc gactacattg ttttctaaca gctgaaaggt agaattgaag 454981 gattcctgat gaggtgttgc gccaagcagc ttgaactgat cctcaatcac atcgctttgc 455041 ataatgcgca gatcctgccc ttttaagtca tccggtgttt tgaccggccc ttgatttgtt 455101 gtgatttgct taaagccgtt cgtccaatag gccaatcctt tcaattggtt tttctttaga 455161 gaatcaaaca gctgtgtgcc gatgcttccg ttcagccctt ttttgacggc gttgtaatct 455221 gtaaatgcat acggcagatc cagcactccc cattcaggcg agagcatgcc gagcttcgat 455281 gtggaggggg cgataaattg aacatcgccg ttttgcaatg cttcaatttc ttcaatgtcc 455341 gagtacaggc ttccattcgg aaatacttct atttttattt ttccgcctga tttttcgttc 455401 accagatcag cgaatttatt ggcggccagc ccttttggcg tattttcagc aaccacgtgg 455461 ctgaatttaa acacgatttg atcctgcagg ccttcctggt cgtcatcata aacaatcttt 455521 ttattgccgg tatgatcatg gaatccgata aataaagcgg ttgcaattcc agcgatcatc 455581 agtgcgagac atgcaagcaa actcttcatg aaaagccctc ccctatgtta aggataatgg 455641 gggctatgac attcgtaaag acctgaaagg agaagctgat gaacaaaaag aagctctcaa 455701 tccgttggaa aatcacgatc ttatcctata tactcgtcat tttctccttt ttgatcggcg 455761 gcattgtgct catcggcaac attcagcata cagaggagcg ggagctgaaa aagcggctga 455821 tgaatacggc ccggacggtg tcagagatga cagaagtgaa agaagccttg gcgcgaaaaa 455881 aacaaacaga agcggttcgc catgcggttg aagaaatcag gatgattaat gaagcagact 455941 atattgtcgt catggatatg aatcacatcc gatatacgca tcctgtcagc acaagcattg 456001 gcaagaaatc agaaggtgca gacgaggagg cagcttttgc ggagcacatt tatttctctg 456061 aagcaaaggg cgagatcggc acggcggttc gcgcttttta tccggtaaag gatcaagacc 456121 tgaaccaaat aggcgtggtg cttgtcggaa aaacgctgcc ggggatcgct gacatcctgc 456181 ttcatttaaa gcgtgatatc gccttcatcg ttgtgctgac actcggcttt ggccttgctg 456241 gttccttttt gctggcccgc catatcaaaa aacaaatgtt tcagcttgaa ccccatgaga 456301 ttgtccgaat gtatgaagaa cggacagcga cgtttcactc gatgaatgaa ggggtgatcg 456361 ctattgacaa tcgtctcgtc attacgatct tcaatgaaaa agcgaaacag atctttgaag 456421 tgcaggggga tctaatcggc aaggtgattt gggaggttct caaggattcg cgcctgcccg 456481 aaatcgtgga gcggaacaaa gcggtttata atgaagaaat tcgtgtcagc ggtaaggtga 456541 tcatgagcag cagaattccg atcgtcatga agaaaaaagt gatcggcgcc gttgcgattt 456601 ttcaggacag aacggaagcg gccaagatgg cagaggaatt gactggtgtc agaaactttg 456661 tggaggcgct ccgtgtccaa aaccatgagc atatgaataa gctgcacacg atcgccggtc 456721 tcatccagct ggggaaatct gaaaaagcct tgcagcttgc attccaggcg tcaactgagc 456781 aggaaaatgt gactgaattt ctgcaccgct cgattcaaaa tgacgctgcg gcaggccttc 456841 tattaagtaa aatcagaagg ggaagagagc tcggcattgc tgttcatata gatgaaaaca 456901 gcagtcttca gcaatttccc gagcatgttg atcagcatga tattgtcgtg cttttgggga 456961 atctgattga aaatgccttc ggctcatttg aaaccgttca atctgaagac aaacgaattg 457021 acattagtat cgaacaaaca gatgatatcc ttgctatttt aatagaagat aacggctgcg 457081 gaattgaacc gacacatatg cctcgccttt atgacaaagg ttttacggtc aataaaactg 457141 gcggcacagg ctatggcctg tatctagtga aacaaatcat agacaaagga tcgggcacga 457201 tagaagttga ttcacatgcg gggcagggga catctttttc tatcgttttt ccaatgaagg 457261 gggaggaagc acagcatggc tcgtaaagaa tggaaggttc tgctcattga agacgatccg 457321 atggttcaag aggtcaataa ggatttcatt acaactgtta aaggcgttac tgtctgtgca 457381 acggcaggaa acggagagga aggcatgaag ctgattaaag aagaacagcc agatctcgtc 457441 attctcgatg tgtacatgcc gaaaaaagac ggcatcaaga ccttgcagga gatcagaaag 457501 caaaagcttg aagtggatgt cattgtcgtc tccgctgcaa aagacaagga aacgatctca 457561 ctcatgctgc aaaacggggc ggttgactat atcttaaagc cgtttaagct tgagcgaatg 457621 agacaggcac tcgaaaagta caagcaatat aaacaaaaaa tcgaagcgaa tgatacgctg 457681 tcccaggaac agctcgatgc gatcctgaat attccgcagc aggccgtaca ggatctgccg 457741 aaagggttga atcacttcac gatgaatgaa gtcactgctt ttttgaaaca gcaaaccgca 457801 tccctttctg ctgaagaggt tgccaaggcg ctcggcatcg ccagagtgac agccagacga 457861 tatcttgatt acttagaaaa aaccgggatc atcaaattgg acgttcaata cggcggagtc 457921 ggccggccgg tcaaccgcta cgtgttaaaa ggataaacct gagaccaaaa agaccaaaat 457981 gtccgttatg atcataaact tccccagact gtatgaaaac gctatcattc tagtaagaaa 458041 gacacaaaag gcgaatagga cagggggatg aaggatatga aactgtttaa aaatttaaca 458101 gttcaggtca taaccgcggt catcatcggg gtcattgtcg ggctggtctg gccggatgtc 458161 ggcaaagaaa tgaaaccgct tggtgataca tttatcaacg ctgttaaaat ggtgatcgca 458221 ccaatcattt tcttcacaat cgttctcggg attgcaaaaa tgggcgatat gaagaaggtt 458281 ggaaaagtag ggggaaaagc gtttatctat ttcgaggttg tcaccaccct cgcactcatt 458341 atcggtttat ttgtcgtcaa tattatgaag ccgggtgcgg gtcttgatta cagcaagctt 458401 gaaaaaggag atgtatcaca atacacgcaa aatggcggtc agggaatcga ctggattgaa 458461 tttattacac acattgttcc gtccaacatg gttgatgcct tcgcaaaagg ggacattttg 458521 caggtcttat tcttttctat tcttttcgga gtgggtcttg cggcattagg cgaaaaagga 458581 aaaagcgtca ttgatttctt cgacaaggtt tctcacgttt ttttcaaaat tatcggctac 458641 attatgcgtg ccgcgccaat cggggcattc ggggcgatgg cgtatacaat cggacacttc 458701 gggctcgatt ccatcaaacc gctggcaagc ttaatgatgt ctgtttatat tacgatgttc 458761 ctgttcgtat ttgttgcttt aaatatcatc tgcaagcttt acggattcag cctgtggaat 458821 taccttcgct tcattaagga tgagcttttg atcgtgcttg gcacaagctc ttccgaatcg 458881 gtgcttccgc gtatgatgga taaaatggag cgctacggct gttccaaatc cgttgtcggg 458941 cttgttattc cgacgggcta ttcgtttaac ctcgacggca catccatcta tttatcaatg 459001 gcgactgtct ttttggcaca ggtgtttgga gtagacctca gcatcggcca gcaaattacg 459061 attatcctcg ttctgatgct gacatcgaag ggagcggcag gtgtgacggg aagcggattt 459121 atcgtccttg cctcaacgct gtcagcgctg caggtcattc cgctggaggg gcttgcactc 459181 ctgctcgggg tcgaccgttt catgagtgaa ggaagagcca ttgtgaacct gatcggaaac 459241 ggaatcgcca cgatcattgt tgccaaaagc gaaaatgaat ttgatgaagc aaaaagcata 459301 gaggctgttg aaggcatgaa aaaaatgaaa acagcagtct gaaaaaagaa cggcccatcc 459361 atgggccgtt tttttaattg tttaagaatt attaaggtaa ggacagagac ctcagcattt 459421 ttttgttata taatttacaa atggatacta tattgaatga aggacgtttg tcctaacagg 459481 agtgtataaa tggccgcttt agttaaattt tttcagcacc cgggagtaag gcgtttctcc 459541 atctttgtcg tgttaactgg tgtgttatat ctatttaaga gcatgatcaa cttaatattg 459601 cttaccttca ttttcacatt tctaatggat cgtttggagc ttgtcgtgcg gcagtttgta 459661 agccagttct tccgcgtgag ccagcgggtt gtcattacgt ttctttacat gttgctggct 459721 gtgctgctta cagtcggggg ctttgtgttt tatccggtcg tcgcggcgca gatccagcag 459781 ctggtaaagc agattaaaca tattgcgtat catcctgaca gcatcccttt ctttgatgag 459841 atcaccagtg tcttcggaga tattaacatc agttcatatg tcaaagaggg cttcaatgta 459901 gtgtatacgt atctggccga tatcagcaca ttcggcttgc aggtcgtgat ggcgctcatt 459961 cttagcatgt ttttcttatt tgagaaaaaa cggctttctg aattcatggc gaaatttaaa 460021 acgagcaaac ttagggtctt ttatgaggag attgcttttt tcggaagcaa atttgcaaga 460081 acgttcggca aggtgctcga ggctcaattt atcattgcgc tcgtcaactg tattctgacg 460141 tttatcgcgc tttggattat gcattttccg cagctgtttg ggctttcgat tatggtgttc 460201 ttccttggat tgatccctgt agcaggcgtc gtcatttccc tgattccgct cagcattatc 460261 gcctacagca ctggcggtgg aatgtatgtg ctctacattg tccttgtcat attcgccatt 460321 catgcgatcg aaacctattt cttaaatccg aagctgatgt cggcgaaaac agagctgcca 460381 atctttttca ccttcacagt actcattttc tctgaacact tcttcggcat ttggggttta 460441 attatcggga ttccgatctt tgtgtttctc cttgatattc tggatgtcac caacaaggaa 460501 gataggtcta aaggaccccg agagaatagc gataaaaagt agtttaaaat cgaataatga 460561 gtgtgcctcg atctgccggc ctgcctgttc agggcatgga attaagactc ggaatcggag 460621 cttggcattg ccttgcacag tggtgaacac aacaggtgac aatgcttgtc atcagtacgg 460681 aaactgaaaa gaacaaacag tcggagcaaa cgctcatcat cggtttaacc aaacatttgg 460741 aagcaacaaa tgctataata caaacagtgc ctaatgttgg gcactgttta ttttttgtcg 460801 aaaaaggagg aaggctttat ggctgagccg attttacata ttgaaggcct cgataaaaaa 460861 attgggtcta aacagatttt aaaacagatc agcatggacg tcatggaggg tgaaatcatc 460921 ggccttctcg gtccgaatgg ttccggaaaa acaacactca tccgtatcat cgtcgggctg 460981 ttgaaacaaa acagcggaag cgtgacaatc agcggattcc agcatgatac agagtttgaa 461041 aaagcgatgg aagcggttgg agcgattgtt gagaaccctg agttctatcc gtacctgaca 461101 ggctgggaaa acctcaagca ctttgcgaat atgcacaaaa aaatagcgga tgaacggctt 461161 gatgaagtgg tggaacgtgt cgggctgacg tcagcgattc atgataaggt gaaaacctat 461221 tcccttggga tgcgccagcg tctgggaatc gcccaggcaa ttcttcaccg gccgaagctt 461281 ctcattctag atgaaccgac aaacggcctc gatcctgcgg ggatgaagga ttttcgggat 461341 catattaagg aactcgcaga aatggaagga acagctgtcc tgttcgccac tcatttattg 461401 cgcgaggttg aagacttgtg cgaccgtgtc atcatcattc aaaaaggtga gatcaaagcg 461461 gaagtcagct tacaaggaac cgatcaaacc acagaaaaag cgattataga agtgcagccg 461521 caagaaaaag cgctcaattg gctgacaggc aatcaatatc aagctgagag ccaagacggg 461581 acgattgtag ttgaggtggc aaaagaaaac ataccggagc tgaaccgatc acttgtcgga 461641 caagatctga atgtattttc cattacgcct tacacgcagt cactggaaga cgaatttata 461701 aaagcgacaa cagctcatca agaggaggga gaagagcttg tctaaattaa tttggaatga 461761 acatatgaaa ctttttaatc ggaaggtcac tttggtttct cttatcctga tggctgtctt 461821 tcaattcttc atggcattga tcattaaacg gattgtcatc agtgccggaa cagatgaaaa 461881 cttcatcggc tatttatcgt atacaccgag cctgaacatt ttgctgcagg ctttaacgat 461941 cgtaattgca gcaacaattg tttcgatgga atttgataaa aagacgatca aatttttgct 462001 cattcgtccg gttaaacgcc aaaaggtctt ttggtcaaaa ttaatcacag tcgtgatggt 462061 cagcttctat ttgtatttgg catactacat tctggcatta ttattcggtc tcttgttttt 462121 tggcacatcg gtgactgcgg aatcaaagac attgctggtc aacaccttgg cgctgatcgg 462181 gtcaaactgg cttgaagctg taatgatggg attattcggg ctgctttgtt cttcgctgtt 462241 ccgcaatagc gcggtagcag ttgttgtttc ttttgtcgtt ttatacggag cgagtacact 462301 tgttcagctc atgaagttgt ttgaaaacaa gtggggcagc tttttgcttt ttgcgaacac 462361 tgactttacg caatacagaa gcggagagac agcgttgttt tcaggcatga cgccattgtt 462421 ttcaattgga attctcatca tacatgccat attcttcatc gttgttggct ggtggtgctt 462481 ctgtaaacgg gatgttcggg tctaaaggca aggaatgaca tttttgtgaa aaagctcacg 462541 taaatcaata tcatttgata ttttggttta tactaaaggt actgacggag gtgtctcgat 462601 tgaggaactt tattaccgct ttaccgatcg tattgctgct tggattctca tttgtgtcat 462661 tcatgtttca gtttgaacat cttgtttatt tcaggctcgc gcttgggttg ttttctctcg 462721 tgggactgta catgatatat aaaatgaaga cgggcatccg ctattttatc atctatctgt 462781 atgccagctg gattgtgttg gccgcagtga ccgcttttga agagccgatt ttctcaagct 462841 ttttctttgg cggcctggtg atgacgatgg gttacctgac atatatgctg atttatctcg 462901 gcatgaaaca agaccgggat gcaaatcctg tgtaatcgcg ctgttccctt ggggaacggc 462961 gtgtttttct atactgggca aaaggttaac agttgcggaa aaatggcagg aaatctataa 463021 tacatattaa atttatcgga attaaaactg gggggctgcc ggatgtcatt atttatacaa 463081 aacgatcaac agcggcaatg gatggagaaa atcggacgga ttgcggatga atttcagcaa 463141 acagctgctg aagatgacga acagggacgt tttcctgcag agaaaataca aaaactgcgt 463201 gatgctgggt atacagcatt aacattgccg gcatctcatg gcggaggggg catttctgtt 463261 tacgatatgc tcttgtttca agaacggctt gcacggggag atgctccgac ggctcttagc 463321 atcggctggc atttgagcgt gatcggggag cttggagaag gcaacagctg ggatgaagac 463381 gtatttgcat ttgttgccaa ggaagtccaa aacggagccg tcattaacag ggcggcgact 463441 gaagcgaaaa ccggaagccc gacaagagga gggcgtcccg gtacacacgc cgtcaaaaag 463501 gatggcaaat gggcagtgaa cgggagaaaa acctttacga cgatgtcaca agctctggat 463561 tattttttag taaccgcatg gattgaggac aaacaaacaa caggcgtgtt tctcattcat 463621 aaagatgatc ccggcttgtc gattgaagaa acgtgggata tgatggcgat gcgggcgact 463681 gggagccatg accttgtact gaacgaagta atgcttgatg agaataagct ggtggaactg 463741 cttcaagggc ctcgtggagc taagccgaat ggctggctgc ttcacattcc tgcgatttat 463801 cttggtgtgg ctcaagctgc tcgtgactat gcagtgcaat ttgcatctga gtattctcca 463861 aacagcttga atggaccgat caagaatgtc ccggccgtac agcaaagaac aggcgaaatg 463921 gagcttgaac tgctcaatgc cagacacttt cttttccata tcgctcaatt gtatgacgat 463981 ccggtgcggc gtccacactt gaccagcgag ctcggtgcgg cgaaacatat cgtcacaaac 464041 gctgcgctgt ctgttgttga taaagcgatg agaattgtcg gggccaaaag cctggaacga 464101 accaacccgc ttcagcgcta ttaccgtgat gtgcgcgccg gtcttcacaa cccgccgatg 464161 gatgacgccg tgatacacaa gctggcagct gaagcgtttg agtcataaaa aaaagagcct 464221 taccggctct ttttatgtat tgttttgctc ttgcagattt ttttgatgct tgcggtcgat 464281 cctgtcataa ataacgttca tcagctttgg attgcccata atcgcctctt tgttttcctg 464341 gatcagctgt tggtaagttt tcactttacg cttcggcatg ctccggcgcc ctcctgacat 464401 gtttgtattc actttctaac tccgtcagcg acaattcata cagatgacgc tttgactttt 464461 tgtatatacc attctgtatt aacagatgaa tgagctgttt ttttctgatt tctgcagact 464521 gaggtgtcat tgtgtcacca acctccaatc aaacgatatt gataatcatt atcaattaac 464581 ttcagtatac aatgtccgca atagcctgta aagatgaaaa gagtcctatt cttggccaat 464641 ttacaaacat tcaacaaatc gacaaaaagt ttcccgggca ataatttgct gtcgaaatat 464701 tccgcttcat tgaacgcacc ctgctatttt tcatgttttg aaccatacta tgtaatagaa 464761 tggaggctgg tattcaatgg agcggacaga aaatctgaaa aagggagaaa aaggggcgct 464821 cctcaatatt tttgcatatg tcatccttgc tgttgtaaag ctagttatcg ggattctata 464881 tcattctgaa gcgctgagag cagacgggtt aaataatgga acagatattg ttgcgtcagt 464941 agcagtgctg ataggattgc ggatttctca aagaccggct gacagcgatc atccatacgg 465001 ccattatcgg gctgaaacaa tttcgtctct tgttgcgtct tttattatga tggcagtcgg 465061 cattgaagtg ttaatcggcg gaggaaaagc gattgcgggc ggcacaacgg aaacgccaaa 465121 tcttatcgcg gcatggacgg cgttaggcag tgctgtgttt atgtatggca tctatttata 465181 taacaaaagg ctggcagcgt ccattaaaag ctctgccctg atggcagcgg caaaggacag 465241 caggtcagac gcttttgtaa gtgccggcgc gtttatcggt gttttttcgt cccagctgaa 465301 gctgccgtgg gttgatccgg taacggcttt tatcatcggc atcatcattt gcaaaactgc 465361 gtgggatatc tttaaagacg cttcacattc cttaacagac ggcttccatt taaaagatct 465421 tgagccttac aaacagaccg tcggcaggat cgaaaatgtg catcgcctaa aggatgtgaa 465481 agcgaggtat ttaggcagta cagttcatat cgagatggtg attacggttg atccgaagct 465541 tacagtagaa gaaggccatg gagtggcgga tgaagtagaa gacaaaataa aacatgaaca 465601 cgatgtcact catgttcatg ttcatgtaga gcctgacgac ataaaataag gctgtttaac 465661 gaattagctt atatgttcag ataaaaattc agtcacttct tcaggcgttt tggcattggc 465721 gctgtgaagg tgagctgttt tttcaccgtt cttgaaaata agcaggctgg gaatgcccat 465781 tacttggtat ttttcagcca ggtcaggaag ctcgtcctta ttcagctcat accagtcgtt 465841 ttggttgtat tcttccaaaa tatcgccgat gaacatattc atgcgtgtgc agtctgggca 465901 ccaatcagca taaaacttta caatgatttc tttatcagat tgaatcagtt cattaaattg 465961 ttcgtttgtt gtgatttttt tcatatgtca catctccttt tcaatgccat tttaatataa 466021 aataaaaagg aattacatac aaatgcattc aacatcagca tgcccaaaaa taattagatc 466081 attttccggt gaaaatgata agatagtaaa gatgaattgt agtgggggga gtatccattg 466141 aaaacaagtc taggattagt gtacggagga aagtcggcag aacataatgt ttccctgcag 466201 acagctctgg ctgtaatcaa agcgctaaat actgagaagt ttgatataca tccgatttat 466261 ataacagaaa aaggcgaatg ggttagaggc gcccgtttaa ctgaacctgt ttcaaacgtg 466321 aaaatgcttc aatttgagca aggaggcagt gctttttctc cagctgccct gaaccaggag 466381 atgtttccgc aggaagcgtc acagcaaaat gaagccatcg acgtcgtatt cccgctcctc 466441 cacggaccga acggagaaga cggtacgatc cagggaatgc tcgagctgtt gaacattcct 466501 tatgtcggca acggagtgct tgcttcctca gctggcatgg ataaagttgt catgaaacat 466561 ttatttgcgc aggttggcct tgctcaggct aaatacgcag ctttccttaa gaaagactgg 466621 actcgttctc cgaaagaaag ctgtgaggag gttgaacagg aattaggcta cccttgcttc 466681 gtaaaaccgg cgaacctcgg ctcaagtgtc ggaatcagca aatgccgaaa ccgtgaagaa 466741 ctgcaaaaag cgtttgagct tgctttccaa tatgaccgca aagtcgtcgt tgaagaagga 466801 attaacggcc gcgagatcga aatcggcgtt cttggaaatg atgatcctaa atgctctgtt 466861 gtgggagaaa tcgcaccgaa gacagatttc tacgattaca aagcgaaata tgaggatgga 466921 gatactgatc tgatgattcc ggcgattgtg actgatgagg aatacgcaac aatcagtgat 466981 atggcgatca aagcgtttaa agcgatcgac ggttcaggac tcgtcagagc ggactttttc 467041 ctgacagctg acggcgaagt tctgatcaat gaagtcaaca caatgcctgg ctttacacct 467101 ttcagcatgt tcccgttgct ctggaaagaa gccggagtgg aatatgctga cctgattgaa 467161 cagcttgtgg agcttgcaaa agaacgccac gctgaaaaac aattgattaa gcatacattc 467221 taatgaagaa ggacactgcc ggtaaaaggg cagtgttttt tcccgtatat acaaaagaaa 467281 gagagggacc ttacttgatt aagcgaacag taaaaaacat tgccgaaatg gttaaaggca 467341 cactagcaaa tccgcaatat gaacaaacag tcattcatgg agtggcaacc gatacaagaa 467401 aactggaaca acatcagctc tttattccgc tgaaagggga acgttttgac ggccactctt 467461 ttgtggagca ggcctttgaa gctggtgtag cggctgttct ttgggatcgg tcagtaccaa 467521 atccgcccga gaatcacgcc gtcattttag tggacgatac ccttactgca cttcagcagc 467581 ttgcaaaagc ttatttgcag gagcttggca cgcgtgtcat cggagtaacc ggaagcaatg 467641 gcaaaacgac aacaaaagat atgattcacg ccgtattggg gacccagtac cgtgtccaca 467701 aaactggagg aaacttcaat aatcatatcg gtttgccgct gacggtttta gcgatgcctg 467761 aaaatacgga gatcgccgta ttggagatgg gaatgagcgc caaaggagaa attgacctct 467821 tgagccgact ggcaaacccg gatgcggcag tgattacgaa tatcggcgaa tcgcatatgc 467881 aagacctcgg ctctagagag ggcatcgcgg aggcgaagct tgaaatcata aacgggctta 467941 aagaagacgg agtgctgatt tatatcgggg acgaaccgct tcttcaaaat gcatacagct 468001 gccagacgaa aacgtacggt acgggaacgc ataatgatta tcagcttcag gatgtcagcc 468061 agagtgagga aggaacccat tttacaatca aagggataga aaacacgttt tttattccaa 468121 tactcggcaa gcacaatgtg atgaacgcca tggctgcaat tgctgcaggg gcttattttg 468181 gcatcgcgcc tgaggatgcg gcaaaaggac tgagcggcct aaaggtaacc gggatgaggc 468241 ttgaactcat caaaacagac agcggccttt cgataatcaa tgacgcttat aatgcgagcc 468301 cgacttccat gaaagctgca attcaattga cagaaagcct tgaaggctac ggcaaaaaaa 468361 tgctcgtgct cggtgatatg cttgaactcg gcgatcttga agaaacgttc cataaagagt 468421 gcggcgctgt gatcagccct gataaaattg accgcgtctt tacgtacgga aaactgggag 468481 cttttatcgc ggaaggcgcc ctgaaacact ttgagaaaga ccgcgtcagc cattacactg 468541 agaaaaaaga tctccttcaa gctgtgaagg aaaacgcatc aaaaggcgat ttgattttat 468601 tcaaagcgtc cagaggtatg aagcttgaag aaatcgttaa agatttaata gagagcccgc 468661 tttcataaga aaatattttg cgaaaaaacg catattgcat cataaaataa cctgatatgc 468721 aaacactaat gtatgccggc cgaaaattat gtatatctgg ccggctgcgg ctatgataca 468781 atatatatag gttatttcgc gatacgaaca tattcgtccg gacttttcat cgtgacccga 468841 agttctccgc tggattcttg ggagcggatg gagcagcagc cggcatattc gagatgccga 468901 tctgcttctc atcttattga aaaacaaata gtgtaatggt aagataaaac ttaaagtaat 468961 tcgggctttg tatacggatg gatcctgtcc ttcttgtcta aagggcagtt ttataagtgg 469021 taaatcacga cattactgaa acagcaatta gaaggagttt gaataatttg actataacgt 469081 ttcaagattt taatttaagt tctgatctca tgaaagcaat taatcgtatg ggatttgaag 469141 aagcaacacc gattcaggca caaacgatac cgctcggact ttcaaataaa gacgtcattg 469201 gacaagcgca aacaggtaca ggtaaaacag ctgcgtttgg tatacccctt gttgaaaaaa 469261 ttaaccccga gtctcctaat attcaagcaa tcgtaatcgc gccaacccgt gaattagcca 469321 ttcaagtatc tgaagaattg tataaaatcg gacaagataa acgtgcgaag gttcttccta 469381 tttacggcgg acaggatatt ggacggcaaa tccgggcgtt aaagaagaat ccgaatatta 469441 ttgtcggaac acctggacgt cttcttgacc acatcaaccg ccgcaccatt cgtttaaaca 469501 atgtaaatac cgttgtaatg gatgaagcgg atgaaatgct gaacatggga ttcattgacg 469561 atattgaatc tatcctttca aacgtgccaa gcgagcatca gacacttctg ttctctgcca 469621 caatgcctgc gccgatcaaa cgcattgcag agcgcttcat gactgagccg gaacacgtaa 469681 aagtaaaagc gaaagaaatg acggtttcta acattcagca gttctatttg gaagtgcaag 469741 aacgtaaaaa attcgataca ctgactcgcc ttcttgatat tcagtctcct gagcttgcga 469801 tcgtattcgg acgtacaaaa cgccgtgtcg atgagctggc tgaagctctg aaccttcgcg 469861 gatatgcagc tgaaggtatt cacggtgact taacgcaggc gaaacgtatg gttgcgcttc 469921 gtaaatttaa agaaggcgca atcgaagttc tagtcgcaac tgatgttgcc gctcgcggac 469981 ttgatatctc aggtgttaca cacgtataca acttcgacgt gcctcaagat cctgaaagct 470041 acgttcaccg tatcggaaga acgggccgtg caggaaaaac aggtatggcg atgacgttca 470101 ttacaccgcg tgagaaaagc atgcttcgcg caattgaaca aacaacaaaa cgcaaaatgg 470161 accgcatgaa ggagcctaca cttgatgaag cgttagaagg tcagcaacag gttactgttg 470221 aacgtcttcg cacaacaatc agtgaaaaca acctgaactt ctacatgaca gcggcagctg 470281 agctgcttga agatcatgat gcagtaacag tggttgcggc ggctatcaaa atggctacaa 470341 aagagccaga cgacacaccg gttcgcttaa cagacgaagc gccgatggtc agcaaacgct 470401 acaagaacca gcgctcttct aaacgcagag acggtcaagg cggcggctac cgcggcggaa 470461 aagggaaaag caacaaccgt tcttcctatg acaaaaagcg ttcaaacgat cgccgttctt 470521 caggtgacag acgccagaaa aaatcttact aatttgatcg attcagagcc caaaacatga 470581 tgttttgggc ttttttatgt tcgtgatttg ttattcagca aactttcagc tgacggaagc 470641 catttttctc tgtatgctta agaatgaaac ctttctgtaa aagagacgta taaataacga 470701 cgaaaaaaag ggaggtaggt atttttgaga gagcagccaa aaaaccaaat cagtccagac 470761 ggattaaagg tttggcgact tcaagagatc atcatatccg ctgtttgctt gcttattgtc 470821 attgcagttg cagtgttaag ctattatttt cattggccgt actggatcag cggcgtgctc 470881 ggcgctgttt ggctgctggg atcgattgtg acggtcttta tcattccgaa ggtccgtcat 470941 aaggtgtggc gatatgaagt ccatgaacat gaaatagata ttcagtcagg tatttttgtg 471001 gtgacacgtg tgattgttcc gatggtcaga gttcagcacg tcgatacgtc acaagggcca 471061 ttattaaaaa aatacaacct ggcaacggtg aaaatttcca cagccgcgac cgttcattcg 471121 atccccgctt tagagatgga ggaagcggat cggctaagag actccatttc ccgtctggcg 471181 agggtgactg acgatgatgt ctgaaccgaa acgcctgcac ccggtggcag tcattttgaa 471241 tttatgccat accattattc aaacgataaa aaatatcatt ctgccattct tttttgtgta 471301 tattgtcaat tcaaaccata ctgtccgttt ttacggagcc attgcgctcg gtgtgctgtt 471361 catctggctt gtagcggcaa gcattatcaa atggagaagg tttacctatc gaattgaaga 471421 tgatgaattt agaattgaag aaggcttatt tgttacgaaa aaacgataca tatcgattga 471481 tcggattcaa acaatgaata cgagcgcggg ccttgtccag caaatcttta agcttgtgaa 471541 gctgcaaatt gaaacagcag gcggaggcaa ggaggcagaa gccgttcttt ctgctatttc 471601 tgttgaagaa gcggaacgca tcaaagaagc tgtctttaag aaaaaagcgc aaagacgaga 471661 aaatgaactt gatgaagaac ggcttgaagc tgaagaggag ttggatccgt ccgttgaggt 471721 gcaagagcac tatcgcatga acgcgaaaga attgctcatg gccgcttcta cctccggcgg 471781 aatcggagtc attatctccg ctgtatttgc acttatttcc cagcttgatg aagtgctgcc 471841 gatggattgg ttattcgata aattttcctt ccttcagcac gccagcatcg gtatttatgc 471901 ggtactcatt tttatcggtt tatttatcgc ctggattttc agcatcgcgg gcatgatgtt 471961 tagatacgcg aactttcaaa tcataaaaaa agagcaggaa ctggtgattt caaggggaat 472021 tattgaaaaa catcaagtca cgattccgct gcgaaaaata caagccatta aaatcaaaga 472081 aaatatcatt cgccagcttt tcggctttgt aacggtgtcc atcgtcagcg caggaggcgg 472141 cgaccgggaa aaagaagaag gcgctttgac cattctcttt ccaatgattc ataaaaaaaa 472201 gcttccgcac atgctccgaa catttacgcc ggaatacacg ctggaagaaa actgccgccg 472261 cctgccgcgg cgcgcgttga aacgctattt gttccgttct gtcatttttt cactcttttt 472321 gatcatcccg ttatgtatct tctttcagcc atggggctat ctgtcagtga tcctgctgcc 472381 gatagaattg ctcttcggct atctcgcgta taaagaggct gcatggacga tcaacgggga 472441 ccgtcttcag ctgacgtcta gatttatagg cagaacaacc gccattgtac tgaaaaaacg 472501 aatgcaggtc tgcaagttca gccaatccta tttccaaaag aaaggccgct tgtataccat 472561 ttctacttcg gtgaaatcat cgagccatat ggaagagtta acggtgaggg acgtaggtga 472621 agaggatgca gccttcattt taaagtggta ctcatatgaa aaagcggacg gttaataccg 472681 ccgctccagc gtgtcggcaa accctcgcat tcgttgtcag gactgcgctt cggtgctcaa 472741 tgcgaagtgg atcaacggct aaattctcag gcgtcctgcc taaacgccgt cgtcatcaca 472801 tcctgtgaaa gtccgctcct atgctcgtcc ttcctagact tcatgggttt tcaatcacgc 472861 tgaaaagatg acaaaatcct aaaatgaaaa ccattttagg attttgtcaa caatctgaag 472921 cggcggttaa taccgccgct cttttttttg cacgcataaa aacgaaagaa gaaacccgcc 472981 gcatagtcca aacaaatggg ccatcatgtt aatattggag ttgataaacg acatgagaac 473041 ggcaaatgcg agcagtgtga tgatcatttt ggaatgctcc tgcccaatta actcattgcg 473101 aaaaagaacc ataaacaggt atacgccaaa tagcccgaaa atggcgcctg aagccccgac 473161 atgcacgtaa tcaagcggct ctgtaacata agtgccgata ttgccgatga tgccggagcc 473221 ggcgtataca agaaggaaac gcgcttttcc cagcatgcgt tccaaagccg gggcaaataa 473281 aaagatggac atggaattaa acagcagatg tgtgaaaccg gcgtgcagca aaatcggtgt 473341 gataagccgc caccattcac cgtttgcgac acctagatta tagcctgtga cggtatccct 473401 ccataacacg actgaatggg caggaagtga aaaaaacagc cagagaacag cttgcaaagc 473461 caatataaag gtgacaacgg ggtaaagcct gataaatgtt tgaaaatttt cagtccgtat 473521 aaacattccg agcccctttt cttcattttg gtatatctat agtaacacgt ttatgagaca 473581 aaccatttaa atagtacgta cgcaaaggag gttatcatac atgatttacg gcattgggct 473641 ggacattacc gagcttaaac ggatcgcctc tatggctggg cgccagaaaa ggtttgccga 473701 gcggattttg acgcgaagcg agcttgacca atactatgag ctttcagaga aaagaaaaaa 473761 cgaatttctc gcgggcagat tcgcggcaaa agaagcgttc tcgaaagcat ttggcaccgg 473821 cattgggagg cagctcagct ttcaggacat tgaaattagg aaagaccaaa atggcaagcc 473881 ctatatcatt tgtacgaaac tgagccaggc cgccgttcac gtatcgatca ctcatacaaa 473941 agaatacgct gccgcgcagg ttgtgattga aaggttgtca agctagtctg catattaggg 474001 aaaccccact catatatttg atagtgcatt aagggagaca agttgtttga ggcttttatg 474061 gtacgcatct gttctgccta aacgtgtacc gagcgtaccg ttaaagtcaa acaagcgatt 474121 tcttcctttt acatcaattg agaaaaaggg gttgaaaaag gtgagaaaaa gctttgtttt 474181 gcttttaacg ggactgcttg ctgttcttat tctttctgcc tgcgggcaaa aaacacagca 474241 agatattgtg gccgggttag atgaaaaggc gaaagaatac acctcgtaca aagcaaaagc 474301 gaaaatgacc atcgagacag ggagtgagcc tcaagtatac aatgtggaaa tctggcacaa 474361 aaagccgtct ctgtacaggg tttatttaga aaatccgaaa aaggaccaaa accaagtcat 474421 tttacgaaat gaaaacggag tattcgttct cacgccgtct ttaaataaga gcttcagatt 474481 tcaaagcgat tggccgaaca acagcagcca ggtttatctg tttgaatcgc tcgtaaagga 474541 tgttcaaaac gattcggatg cagttttcac agcgaaagaa aagaaatacg tatttgaaac 474601 aaaaacaaac tatcagcata acaaaatgct gcccacgcaa gaaatcacat ttaacaaaaa 474661 agatatgagc ccgtcatctg tcaaagtgat ggatactgac cggaaagtga tggtcaaagt 474721 agaattcagc agctttgaat ttaataaaca atttgataaa gaatcatttg atgaaaagaa 474781 aaatatgacc ctttctcaaa tggatgtcgc cacaagcgca aagccttccg atacatttgc 474841 ggtcaaaacg ccgctggaac tgccgcttgg cgtcaagctg cttgaagaaa aagatatatc 474901 tactgaagac gggaagcgca tcatcatgac gtacggagga gaaaaatcat ttacgttaat 474961 tcaggaaaaa gcccagattg ccaaggcttc ctcctccgtt acgctgaacg gcgaaccggt 475021 aaatctcggc tacaccatcg gcgccctgtc ggatgcatca ttatcatgga catatgacgg 475081 cgtagattac cttctctctt ctaaagatct ttctaaagag gaaatggtga cagtagcgaa 475141 aagcatgcag ggacaatcat cgaaataacc gccaaaggcc aaacatgatt tggccttttt 475201 ttcgttagac atcgtttccc tttagccttt aattttagta tgatatgtaa atgatattga 475261 ataaaagcta ggaagtgtcg taatgagcac aaaacctttt tacagagata cgtgggcgga 475321 aattgacttg tccgcgataa aggaaaatgt cagcaatatg aaaaaacata tcggtgaaca 475381 tgtccacttg atggcagttg tgaaagcaaa cgcctacggg catggtgatg cagaaacagc 475441 aaaggctgct cttgacgcag gtgcttcatg cttggccgtg gccattttgg atgaagcgat 475501 ttcactgcgc aaaaagggat tgaaggcgcc tatattggtg cttggcgcgg ttcccccgga 475561 gtatgtggca atcgctgctg agtatgacgt gaccttaaca ggttattctg ttgaatggct 475621 tcaggaggca gcccgccaca cgaaaaaagg ttctcttcat tttcatctga aggtcgatac 475681 ggggatgaac agacttggtg taaaaacaga ggaagaagtt cagaacgtga tggcaattct 475741 tgaccgcaac cctcgtttaa agtgcaaagg ggtatttacc cattttgcga cagcggatga 475801 aaaagaaaga ggctatttct taatgcagtt tgagcgcttt aaagagctga ttgctccgct 475861 gccgttaaag aatctaatgg tccactgcgc gaacagcgcc gctggactcc ggctgaaaaa 475921 aggctttttt aatgcagtca gattcggcat cggcatgtat ggccttcgcc cgtctgctga 475981 catgtcggac gagataccgt ttcagctgcg tccggcattt accctgcatt cgacactgtc 476041 acatgtcaaa ctgatcagaa aaggcgagag cgtcagctac ggagccgagt acacagcgga 476101 aaaagacaca tggatcggga cggtgcctgt aggctatgcg gacggctggc tccgaaaatt 476161 gaaagggacc gacatccttg tgaagggaaa acgcctgaaa attgccggcc gaatttgcat 476221 ggaccaattt atggtggagc tggatcagga atatccgccg ggcacaaaag tcacattaat 476281 aggccggcag ggggatgaat atatttccat ggatgagatt gcaggaaggc tcgaaaccat 476341 taactatgag gtggcctgta caataagttc ccgtgttccc cgtatgtttt tggaaaatgg 476401 gagtataatg gaagtaagaa atcctttatt gcaggtaaat ataagcaatt aacttaccta 476461 aatggagaat tcataaaaca gctttgcttg aagagtgaat aatggtatca ttatcactgg 476521 atggataaaa gagtcgtatc cgtaagtttg gtggaggtgt atgttttttg tctgaatcca 476581 gcgcaagaac cgaaatgaaa atcagcttgc ccgaaaacct agtagctgaa ttggatggtg 476641 tagcgatgcg ggagaaacga agcagaaacg aactgatatc acaagcagtg agagcgtatg 476701 tcagcgaacg aacaactcgt cacaaccgtg atttgatgag acgcggctat atggaaatgg 476761 cgaaaatcaa cctgaatatt tcttctgagg ctcactttgc ggagtgcgag gctgaaacga 476821 cagttgagcg cttagtcagc ggaggataat catttgattg tgaaacgcgg cgatgtttat 476881 tttgctgatt tatctcctgt tgttggctca gagcaaggcg gggtgcgccc ggttttagtg 476941 atccaaaatg acatcggaaa tcgcttcagc ccaactgcta ttgttgcagc cataacagca 477001 caaatacaga aagcgaaatt accaacccac gtcgaaatcg atgcaaaacg ctacggtttt 477061 gaaagagatt ccgttatttt gctggagcaa attcggacga ttgacaagca aaggttaacg 477121 gataagatta ctcatctgga tgatgaaatg atggataagg ttgatgaagc cttacaaatc 477181 agtttggcac tcattgattt ttagacatat ttgcaggttg ctcaaataga gcaacttttt 477241 ttgttttcaa aaaacataaa cgatataata gtgaaataac gaaaaaatat gttgtttttt 477301 attgggaggt aagcgaattt gatgtcgaac cagactgtat accagttcat tgccgaaaat 477361 caaaatgaac tgctccaact gtggactgac acactaaaag aattaagcga gcaagaatcc 477421 tatcagctga ctgaccaagt gtatgaaaat atatctaaag aatatatcga cattctgctg 477481 ctgtctgtta aggacgaaaa tgctgctgaa agccaaatca gcgaactggc gcttcgagcg 477541 gtccaaatcg gactgtctat gaagtttttg gctactgcac ttgccgaatt ctggaagcgt 477601 ctctacacga aaatgaatga taagagattg ccagatcaag agagcacgga attaatctgg 477661 cagattgatc gctttttcag cccgattaac acagaaattt ttaatcaata ctcaatctca 477721 tgggaaaaaa cagtatccct gcaaaaaatc gcgctgcaag agctgtctgc gccgcttatc 477781 ccggtgtttg aaaatatcac tgtgatgcct cttgtcggaa caattgatac cgaacgcgcg 477841 aaacgaatta tggaaaacct tcttaatggc gtcgtcaaac accgttccca agtcgtgctg 477901 attgacatta caggtgtccc tgtcgtcgat acgatggttg cccatcatat tattcaggca 477961 tcagaagctg taaggcttgt cggagcaaaa tgcctgctgg ccggaatccg tccggaaatt 478021 gctcaaacaa tcgtcaacct ggggattgat ttatcccaag ttataactaa gaataccctg 478081 caaaaaggaa ttcaaacagc attggaaatg acggatcgaa aaatcgtttc attgggggaa 478141 taacattttg agacatccga aaatcccgat cttgaaactg tataattgct tattagtgtc 478201 cattcagtgg gaacttgatg accagacagc attaactttt caagaagact tattaaataa 478261 aatatacgaa acaggtgcta acggagtcgt cattgacctg acatctgtgg atatgattga 478321 ttcatttatc gcgaaagtgc tgggggacgt cattacaatg tctaagttaa tgggggctaa 478381 agtcgtcttg accggcattc agcccgctgt ggcagtgacg ctgattgaac ttggaatcgc 478441 gcttgaggaa atcgaaactg cgctcgactt agagcagggg cttgagacat tgaagcggga 478501 attgggggaa tagcgaatga acgaccaatc ctgtgtaaga atcatgacag aatgggatat 478561 tgtggccgcc agacagctgg gacgaaacgt tgcgaaagaa ctgggtttcg gcacggtaga 478621 ccaggctaga attacaacgg ctatttcaga attagccagg aatatttatt tatatgccgg 478681 caaagggcag attggaattg aacaggtcgc agacagagga aaaaaaggcc tgaaaatcat 478741 agcggaagac caagggccgg gaattcctga tatccgaaaa gtcatggaag acgggttttc 478801 aacgtctgga ggacttggtg cgggacttcc cggggtcaaa aggctgatgg atgaattcag 478861 cttaaattcc gtagcggggg aaggaacaga gatacaagcc atcaaatggc ttcggtagga 478921 ggtaagaacg tggattttag ggaggttatt gagcagcggt atcatcagct gcttagtcga 478981 tatatagccg aattaacaga aacatcttta tatcaagccc aaaaattcag ccgaaaaaca 479041 atcgagcacc aaattcctcc ggaagaaatc atcagcattc acagaaaagt gctgaaggag 479101 ctgtatccaa gtctcccgga agatgtgttt cattcgctgg attttttaat agaagtcatg 479161 attggctatg gaatggctta tcaggagcat caaaccctta gagggataca gcaggaaatc 479221 aaatcagaaa ttgaaatcgc ggcaaatgtc cagcagacgc ttctcggaac taaagttcct 479281 caggaggaag cgctggatat cggcgccatc agtgttcccg ctaaacagat gagcggtgat 479341 tactaccact ttgtcaaaga caaggaatcc atcaatatcg caatcgcgga cgtgatcgga 479401 aaaggcattc cagcggcttt atgcatgtcc atgattaaat acgcaatgga ctctttgccg 479461 gaaacgggca tacacccttc tcaagtgctg aaaaatttga atcgtgttgt tgaacaaaac 479521 gttgatgcca gtatgtttat tacgatgttt tatgcgaatt acaatatgga caagcatcaa 479581 tttacatatg cttcagcggg acatgaaccg ggattctatt attctcaaaa agacaacacg 479641 ttttacgatt tagaggccaa aggactcgtt ctcggcatct cgcaggacta tgactacaaa 479701 caattcgatc agcatctgga aaagggcgat atgattgttt tattttctga cggcgtcaca 479761 gaatgcagaa cggaaaacgg tttcttggag cgtcctgatc tgcagaagct cattgaggaa 479821 catatgtgtt cctctgcgca ggaaatggtc aaaaacattt atgacagcct cctcaaattg 479881 caggattttc agcttcacga tgattttacg ttaattgttt tgcggagaaa ggtttaacgt 479941 ctgtcagacg agggtataaa gcaactagtg atttgaagga aaatttgagg tgatacgaat 480001 gaatataaat gttgatgtga agcaaaacga gaatgatata caagtaaaca ttgcaggaga 480061 aattgatgta tactcagccc cggtgcttag agagaagctc gttcctctgg cagaacaagg 480121 agctgactta agaatttgcc tgaaagatgt cagctacatg gacagtaccg gattgggcgt 480181 ttttgtaggg acctttaaaa tggtgaaaaa acaaggtggt tcgctgaaac ttgaaaatct 480241 ttctgaacgg ctgatccgac tgtttgacat tacaggcttg aaggacatca ttgatatttc 480301 tgcaaagtca gaaggtggag tgcaatgaag aataatgctg attacatcga aatgaaagtg 480361 ccggcccaac ctgaatatgt gggaattata agactgacgc tgtcaggggt cgcaagcaga 480421 atgggctata cgtacgatga aattgaagac ttgaaaatcg cagtcagtga ggcgtgcaca 480481 aatgcggttc agcacgctta caaagaagat aaaaatgggg aagtgtcaat acgattcggt 480541 gtgtttgaag accgtttaga ggttattgtg gcggatgaag gagacagctt tgactttgat 480601 caaaagcagc aggatctagg gccgtacaca ccttcgcaca cagttgatca attatcagaa 480661 ggagggctcg gtctatattt aatggaaacg ctcatggatg aagtcagagt gcaaaaccac 480721 tccggcgtca ccgtagcgat gacaaagtat ttaaatgggg agcgagttga tcatgacaca 480781 accatcaaaa actacgaaac taactaaaga tgaagtcgat cggctcataa gcgattacca 480841 aacaaagcaa gatgaacaag cgcaggaaac gcttgtgcgg gtgtatacaa atctggttga 480901 catgcttgcg aaaaaatact caaaaggcaa aagcttccac gaggatctcc gccaggtcgg 480961 catgatcggg ctgctaggcg cgattaagcg atacgatcct gttgtcggca aatcgtttga 481021 agcttttgca atcccgacaa tcatcggtga aattaaacgt ttcctcagag ataaaacatg 481081 gagcgttcat gtgccgagac gaattaaaga actcggtcca agaatcaaaa tggcggttga 481141 tcagctgacc actgaaacac aaagatcgcc gaaagtcgaa gagattgccg aattcctcga 481201 tgtttctgaa gaagaggttc ttgaaacgat ggaaatgggc aaaagctatc aagccttatc 481261 cgttgaccac agcattgaag cggattcgga cggaagcact gtcacgattc ttgatatcgt 481321 cggatcacag gaggacggat atgagcgggt caaccagcaa ttgatgctgc aaagcgtgct 481381 tcatgtcctt tcagaccgtg agaaacaaat catagacctt acgtatattc aaaacaaaag 481441 ccaaaaagaa actggggaca ttctcggtat atctcaaatg cacgtctcgc gcttgcaacg 481501 caaagctgtg aagaagctca gagaggcctt gattgaagat ccctcgatgg agttaatgta 481561 atgatccagg ttgaagaaaa cgagcatatt caaactctag tatatcaact gaataaagaa 481621 gggaaatcga tttgcggtga cagttttttt atgaaagctg atgataagga gttaatttgc 481681 gcggttgctg acggactggg aagtggatca cttgctaacg aatcctctgc agccatcaaa 481741 gacttagtgg aaaactatgc gagtgaagac gtagaaagca ttatcgaacg ctgtaatcag 481801 gcgatgaaaa acaaaagagg cgctacagca tctatcctga aaatcaattt tgagcaaagg 481861 cagtttacgt actgctctgt cggaaatgta cggtttattc tgcattcccc gtctggtgaa 481921 agcttttatc ctctgccgat ttcgggctat ttatcaggca agccgcaaaa atacaaaacg 481981 cacaccgcca cctatgaaaa gggttcaaag ttcattatac atacagatgg actcaacgta 482041 cctgatatcc gctcccattt gaaaaaaggc caatcggtag aagaaatatc gaattcgctg 482101 aaaatgtata cgacatcgag aaaagatgac ctgacctata ttctcggaca gctgtcctaa 482161 aaaaccagaa aaagaagctg gacatccggc ttcttttttt tgcggttgac tattaataag 482221 tgcgcttatt atacttaata agtgaactta tcattctggg agcttatggg atgtggaatt 482281 atgaatacac agcgatagct gatgtggatg tgggaaaacc tggaactgtt atcaggaaac 482341 agaaacaatg gatcaatggg agacgggtat tgcatcagat tctttgaaag gacaatttca 482401 aaatggaacg gaaggaacat tgcttctgca aggaaaaaca attctcttat ggcttgagca 482461 tgtggagaaa catcgggcgt tttctgtcat ggtcaacatg cccgcatagc aatgtaataa 482521 tggagttttt tcacgtgctt caaaagcaaa aagaagattt gtgtatcaca tatggaattg 482581 tattagaagg cgctgaagca aaaaagtggg gagaaatcat tgggactgaa ctgtctaaag 482641 acatgccgac ggctgtcagc aggcttgtcc atctttacgg aggagtgata aaatgaacac 482701 aaattactgg atcggcgttg tgtcagagca acatgtatta aaaggcgctg ccggcggttt 482761 tgcacagctg tgccatggaa aaaaagcccc gctcgccaaa atgaaagagg gagattggct 482821 gatttattat tctccgagag acgcatatcc agacggcaaa ctgctgcgaa gctttactgc 482881 gatcggcaaa gtaaaaagcg gaaacatcta tccgtatcaa atggctccga attttattcc 482941 ataccgatta gatatagact attatccatg ccataaaatc ggtttttacg acattaaatc 483001 aaagcttgaa tttgttcagg aaaccaagca tcttggcttt ttatttcgca gaggacactt 483061 tgaaataagc aaaaaagatt ttttgacaat agcacaagcg atgggagtta acataagtgg 483121 aatggcactc taaatttagc ggtccgaaca caagcccggg ctttttatta tggcaggcca 483181 cgcaaagttg gcagcggaaa gtaggaaaag cattggctga gtttgacctg acccacgttc 483241 aatttgttct gctgacctcg tgcaagtata tgattgctca cggagaaacc gtcacgcaaa 483301 aaaaacttgc aagcttcagc cagaccaata tcatgatggt ttcggaggtt gtgcggacgc 483361 ttgagaaaaa aggatttatc gaaagaagca aaaatcccca ggataaaaga gaggtcctcc 483421 tgtctcttac agaaatagga ggagaaaaag taacagcggc tttgccaatt gttgagaaga 483481 ttgatcaagc cttctttgca gctgcgatga aaaaagagaa ttttctgagc ggcttacagg 483541 aactattgaa acatgagtaa agatacgggc agcgccagct gtcttttttt atgtgttttt 483601 ttcggttttt gatacactag agaaagaacg acaaaattgg aggctttggt tacatggaaa 483661 cgtcagccct tttaaaacag caaattgcga aagaaatagg tttatcacaa aaacacgttg 483721 aaagtgtcat ccgcctgctt gaggacggca atacagtccc gtttattgcc cggtatcgaa 483781 aagagcagac gggttcaatg gatgaggttc agattcagac gatttctgaa cgctggcaat 483841 acatacaaaa cctgaatcag cgaaaagaag aagtcatcag gctgattgca gagcaggata 483901 aactgacaga taatctaaaa cgtaaaatcg agcaatcggt gaagcttcag gaagtggaag 483961 acctttaccg cccttataaa caaaaacgta aaacaaaggc gacagtcgcc aaaagcaaag 484021 gccttgagcc gcttgccgac tatatcctga cacttcccca agatgatcat ctggcagcaa 484081 ctgcagacca atacatcagc gaagaaaaag aagtgttcac acgagaagaa gcgattgaag 484141 gcgccaagca cattattgcg gaacaaatct cagacgagcc gaccttcaga aagtggattc 484201 gccaggaaac cttcaaaaga ggaaccatta agtctgcagc cggaaagtcg gcagacaccg 484261 atgagaaaaa tgtgtatgaa atgtattacg agtatgaaga gccaattgca aaagttgttc 484321 cgcatagggt gctggcaatg aaccgcggcg aaaaagaaga cattttaaag gtagcgatcg 484381 aaccgcctgc ggatcacatt aaggcgtatt tagaaaaaca aatcatcaaa aatcgctcaa 484441 catccgtaag agagattttg caggagacaa ttgaagacag ctataaaagg ctgatccagc 484501 cggcaatcga gcgtgaaatc aggaaagagc tctcagaaaa agctgatgaa caggcgattc 484561 atattttctc agagaacttg agaaagcttc ttttgcagcc gccgatgaaa ggcaaaaccg 484621 ttctcggtgt tgacccagcc tttcgaactg gctgtaagct cgctgtgtca gatgagaccg 484681 gaaaagtctt gaaaattgat gtgatctatc cgcatgcgcc agtcaacaaa acaaaagaag 484741 cccatgaaaa agtgaaaaag attcttgagc agtatcaagt cgagatggtg gcgatcggaa 484801 acggcacagc atccagagaa acagagcaat tcatcgtcaa tgtactcaga gacatgccgc 484861 gcaaaattta ttatgtgatc gtcaatgaag cgggagcaag cgtctattcg gcttcagagc 484921 ttgccagaga agaattccct gaccttaagg ttgaagagcg cagtgccgta tctattgctc 484981 ggagacttca agacccgctc gcggagctcg ttaagatcga tccgaagtct gttggtgtcg 485041 gacagtatca gcatgacgtc agccaaaaac gcttaaatga atctctgcgg tttgtcgtcg 485101 aaactgtcgt aaaccaggtt ggagtaaacg tcaacacagc ctccgccgcg ctgcttcaat 485161 atgtagctgg attatcgaag tctgtagcag gcaacgttgt caaaaaacgt gaggaaatcg 485221 gaaagttttc aaatcgaaaa gaactgaagg acatcccaag gttaggtgcg aaaacctatg 485281 agcaatgtat cggtttctta agagtgcagg aagggacaga gcctttggat agaacaggca 485341 tccacccgga aagctataaa gaaacaaaag cacttttgaa aaaactcgga ctttcaacag 485401 aacatatcgg cacggcggaa ttgaaggaca aaatcaatca gctggcgctc tctgaaacgg 485461 caaaagagct gggaatcggc gaaatcactc tgaaagacat ttgtgaacag ctgacaaggc 485521 cggaacgcga tccacgcgat aaggtgccta agcctttgct gaaaacagac gtccttcagc 485581 tggaagattt gaaagaggga atggaactgc agggcaccgt gcgcaatgta gtggacttcg 485641 gagcgtttgt tgatatcgga gtcaaacaag acgggcttgt gcatatctca aaattgagca 485701 atcaattcgt caagcatcct cttgatgtcg tatctgtcgg cgatattgtg acagtttggg 485761 ttgacggcgt agatgtacaa aaaggcagag tatcgctgtc tatggtaaaa taaaagcact 485821 gcttacgagc agtgtttttt cctatagaaa taccagcatt gattcagcag tttaatttgg 485881 taattatctt tttcaaggaa cgctttttgc atctgctttt taagccaatt tggcataggc 485941 tcattcctcc tcagctttta tcataagagg gacagtgatt accatattgt atgcgaacgg 486001 tgaattgtcc cgttcaatgt tttttaagtg aggtgcacca tggataacaa agagcttcaa 486061 aagctgacag aggatatttc tgaaacatat tttaaaaagc cgttccgcca tcaggcgctt 486121 tttaatgacc ggcttaaaac cactggcggc aggtacctgt taacctccca taacattgaa 486181 ttgaacagaa aatatttgat tgaacacggc agggaggaac tgattggcat catcaagcac 486241 gagctctgcc attatcatct tcatcttgaa ggaaaagggt acaagcacag agacagagat 486301 tttagaatgc tattgcagca ggtcaacgcg ccgaggttct gtacacccct taagaaaaaa 486361 gcggaaaaca aaaaaactta tatgtatatc tgtacgacct gcggccaaca gtatataaag 486421 aagcgcgcca tgaaccctga cagatacaga tgcggaaaat gccgcggaaa aataaaaaga 486481 attttttcgt gaaaaaggtt gacgaatatg gcaagcctat gttacattat aaaagtcgtc 486541 acgagagata aataaaaaca tttacctctt gacactgcaa atcaaggctg atataataag 486601 tcttgtctca ttattccaca gtagctcagt ggtagagcta tcggctgtta accgatcggt 486661 cgcaggttcg aatcctgcct gtggagccat attggagaag tactcaagtg gctgaagagg 486721 cgcccctgct aagggtgtag gtcgcgtaag cggcgcgagg gttcaaatcc ctccttctcc 486781 gccataagat ttcgatataa gttctcaacc atcggcccgt tggtcaagcg gttaagacac 486841 cgccctttca cggcggtaac acgggttcga atcccgtacg ggtcattcca tttcgttggg 486901 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 486961 tagcccagcc atttttattt ttgaaatcta atagtaagag ccattagctc agttggtaga 487021 gcatctgact tttaatcaga gggtcgaagg ttcgagtcct tcatggctca ccatttgtct 487081 ttttgcgggt gtggcggaat tggcagacgc gctagactta ggatctagtg tcttacgacg 487141 tgggggttcg agtcccttca cccgcacttt atttacaaag tgcacgcaaa tctgttttac 487201 taggttaaga gcctactaaa ccagcacaac acaatttaat gatcacgcgg tcgtggcgga 487261 atggcagacg cgctaggttg agggcctagt gggtgaataa cccgtggagg ttcaagtcct 487321 ctcggccgca tctcaataat accaagggtt taaccacctt tggtattatt tttttgtgtg 487381 gaaaatacgg ctatgggaga agacttgctc accaaaactc accagttact taaagtaagt 487441 catccaaacg gtcggcggtt ccttctgttt attaggaaaa agatatccgt tcattgtaaa 487501 agaaacgaac catgtcctat tcgttcaaaa aaactaaagg gtgatacata ttatacatga 487561 ttaatatgta tcaccctttt ctttcttgtt caacaatcgc gcttgaggag aacataagct 487621 aatacaactg actcgatttc taaagttgct ccattctttt tttaaacaac tcatccacaa 487681 cctgttttaa aatctcgtac gactgaattt ccttgctcaa ttcgtaaata ttagataaca 487741 caattaattc atctgcgtga tacatttgtt ggaaatcaat tagttcgcga cgaattgttt 487801 ctcgatcacc catgattgta taccccagtc gactgtggag aatttctaat tcaaactgtg 487861 ataacgattc taggaagttt tcagtgggtg gaataagctt acttaaatta tttgtataaa 487921 tatcaatata cacctgcaaa tgacttgcag aaataaaaga tgcctcgtct atagattctg 487981 ctgcaatcac attaatgcaa gcgatcacat aaggttcttg taaataagaa gacggttgga 488041 aattttctcg ataaatagag agcgcttctt ccatcgaatg gggtgaaaat tgagcgccaa 488101 atgcataggg taaaccaagc tttgcagcaa tttccgctga atccgttgag gatcctaaca 488161 caaaaacagg cacatgcgtt ccaatacccg gataagcgcg aacctcaccc tgtacactct 488221 tatccccgac aaaacgcaaa atatcattta cttctctttc aaagaaaaac actccattat 488281 ggttggaacg acgaatcaca tcggccgttt tttgatccgt tccgggtgcg cgtcctaatg 488341 ccaaatctac acgatttgga tataatgttt caagtgttcc aaattgctcc gctacgatta 488401 atggggaatg atttggcaac ataatacccc ctgaacctac gcgaatgtct tttgtatttg 488461 ctaatatatg ttgtacaatt gatacggttg ctgcacttgc ataagcgtcg tgattatgat 488521 gctctgcaaa ccaaatccgt ttatagccca tattatctac agctttagct aatgacactg 488581 cagaatcaat cccttgtttc attgtttctc cttgtcttaa tggagcaact gataaaacag 488641 atatatcaaa ttttttcata atttcacctc taaaataatg aacttataca agatcaatgg 488701 aaaaaacatt ttgaaaaatt gtttcatatt aaatggtgtc cattcctctt tgatttgcat 488761 gcaaataaat atatactttc tcaaacgatc aatacatagg caaaataaag ttatttcaca 488821 atttcacttt acttttaaag ttttaagcaa acataaaaaa atgttcagtg aacaaaatat 488881 gtaaaataca tcttattttt cagaaaggat acaagaaaat gattgatgaa atagataaaa 488941 aaatacttga tgagctgtct aaaaatagtc gccttacaat gaaaaaatta ggggaaaaag 489001 tacatctcac tgcaccagca accgcatcaa gagtagtaaa gttaatagac aatggcataa 489061 taaaaggatg tagtatcgaa gtgaatcaag tgaaattagg cttctctata catgcttttc 489121 ttaatattta tatcgaaaaa atccatcatc aaccctattt agcttttata gaaacacaag 489181 ataactatgt aataaacaat tataaagtta gtggagacgg ttgctatttg cttgaatgta 489241 aatttccttc aaacgaggta ttagatcaat ttttaaatga cttaaataaa catgcaaact 489301 ataaagtgtc gattgttatt ggtaaatagt taactttata aaacggagat gtgcggtcat 489361 ataacatgat atatatgctc taaaaaagcc ctaggttgga tatggaattt accaagctgg 489421 ggccttttta tacattataa taacaagcgc attattcatc agacattaat gaagtattat 489481 aatgcttttt tacttcctta atagacaaat aaagctgata gtttccatac ttcaataaat 489541 cattcagaag gtgatttaaa acttcttgtg aatgaaccgt taccttcaga agataacatg 489601 catctcccga aacacgatga gcttcgctaa tttcattacg agtagcaata aatttcaata 489661 aatcatcatg catatatgca ttcatgaaaa agaagacaaa ggctgtaaaa gaaaacccca 489721 tcttcaattc atcaaccaca atcgaatatg ctttaatgat accgttatcc tccatttttt 489781 tgatgcgatt gcctaccgct tgtcctgtca tatgaatttt ttcaccgatt tctttccatt 489841 gtatccgagc atttttattt aataattgga gaatttgaaa atcaattgaa tcaatttgca 489901 tagtaactcc tttcacagtg aaaaagtttt acaaaatagt atttcatgag accatcgaaa 489961 attcaatgga aattatatat ccttatacag tataaaaatt ttaagaggtg aaaaaatgac 490021 aacagcttta ttagtgattg atattcaaaa tgattacttt ccaaatggga agatggcttt 490081 aacaaaccca gagaaagcag cacaaaatgc ggctaaacta ctttcacact ttagaaacac 490141 aggcgcacct gtctttcatg tacagcatat cacagaaggt aacatcgctc attttttcca 490201 tccaaataca gaaggtgtcg aaattcatga gtcagtacgt ccattagaga aagagacagt 490261 cattgtaaaa catatgccga atagcttttt caatacagat ttaaatggaa agctacaaga 490321 agaaggggtt aaagaattag ttgtttgcgg tatgatgtcc catatgtgta ttgatgcaac 490381 agttcgttct gcagttgaac atggttatgt atgccaagtg gtagaagatg cttgcgcaac 490441 aacaacattg caaattgaag ataaaatcgt tcctgctgag catgtccatt acgcatttat 490501 ggccgcatta aatggtgtct atgcaacagt aaaaaccaca gaggcatttt taaaataaaa 490561 gaatttcctg cgcgaacata acgtctttct tttcacaaga aagatgattc aacaacttaa 490621 aaaaggatgt tcagaaaaat acttctggac atcctttatt cattatcttt tattgttttt 490681 cagtatcatt attcccatct gataaaagat caagatgtcc tgtttttgat ccatagtaag 490741 accatataca gggattgttt ttgccataaa tatagatatt gatgaaggtt tacataaagc 490801 acctaattgc ttgatttact ttaatgttag atccctcaat aactccattc tcttctaatt 490861 tctctactct agctgtagct gctgggcatg ttaaatgtac tctctcccag atctttcatt 490921 gaattcggct attatacata atttctctat aattttttat ctgtttgatc tatttgaacg 490981 ttaattcctt tcgaaaataa agtcaaagag ttaaaacact tttttttatc tatgtattcg 491041 aacactgctg atattataca cttaactctg tcgatctaag acaaataaaa aaagaaagtg 491101 agttgtaaat atgaatatta cacaaattcg aaatgcaaca attgttgtaa aatacgcaaa 491161 taaaaaattt ttgatagatc ctatgttagc agagaaaggt acgtacgcta ctttccctga 491221 aacgatcaga caagatttat ttaatccttt ggtgagtttg ccaacatcaa ttgataacat 491281 tctggatggc gtagatgcgg taattgttac tcatctacac ctagatcact ttgatgatgt 491341 ggcaaaaaac gtattgccaa aaaacatcaa aatgtttgtt caaaatgaag cagatgcaaa 491401 agaagtaaaa gcaagtggtt tcaaaaatgt agaagtgcta catcaagaca ctgtttttga 491461 agggatccaa ttagtaaaaa caaaaggtga acatggcaga ggggaagagt tattaaactt 491521 aatgggtgat gtttgtggat tagtattcaa gcacccaagt gaaaaagttt tatatgtagc 491581 tggggataca gtttggtatg atgctatcga agacgagatt catacacatc aaccagaaat 491641 cattgtggtt aatggtggag acaatcaaag attagattta ggttcactca tcatgggaaa 491701 agaagacatc tatgaagttc acaaggctgc tcctcatgct aagattatat ctgttcatat 491761 ggaagctgtt aaccattgga cactatctag agaagaatta aaaaacttta gtaaagaaaa 491821 aggattctca agtaatattt tagtgccaga agatggcgag tcttacacat tttaatatga 491881 acaccgacaa ataaatagaa gaagctcata attataaaaa ctaatcatga gcttcttcta 491941 ataatgaata ttttaaattt taaatatatc gaaaatccta aatatacgga ataacaaaaa 492001 tggaatgttc caatgatgac aaaaaaactt gaaaagcaac aaagatgtgt cgttaggagg 492061 tagaattcat ggtaatgaca aaaaaagata caaatatatc aacacagcag cctctttggt 492121 tacaaggtta tattgattca ccagaaaaac aaaaccaact ttataaaaaa acattaaaaa 492181 tcttgatttt ttcacaaata tttgggggag caggacttgg agctgggata acagttgggg 492241 cgcttcttgc acaagatatg ataggatcgg aaaatgtagc aggaattcca actgccctct 492301 ttacttttgg atctgccgta gctgccctgc ttataggagc atcctcacaa cgttttggtc 492361 gcagagctgg acttgcaggt ggtttcctta taggcggatt aggtgctata ggtgtgataa 492421 tcgcggcttt aattaacagc gttgccctat tatttgtttc tcttcttatt tatggagcag 492481 gtatggcttc taatcttcaa gttcggtatg ctgggacaga ccttgcaaat gagaaacaac 492541 gggcaactgc tgcaagtatg gccttagttt ctactacttt aggagctgta gtaggtccta 492601 acttagttaa tacaatgggg gaatttgcag attcaattgg tgttcccaat ttagctggtc 492661 cgtttattat gtcaggagca gcttttataa ttgctggaat tattctctta atttttcttc 492721 gtccagatcc gctgtttgta tcaacagcta ttgcgaatgc tgagaaaaaa gacgataaag 492781 tacaaatagg aggaagtcta aaaaatcctg ctatagacaa aaaaggaata atggtaggag 492841 ctgtcattat gattttagct caactaatca tgacagctat tatgacaatg acaccggttc 492901 acatgggtca tcacggtcat ggtttaagcg aagtgggatt agttatagga ctccatattg 492961 cagcgatgta tcttccttca ccattgactg gtttattagt agataagttt ggtcgcacaa 493021 ctatggctat tgcttcaggt gccacacttc ttgccgctgg gttggtggca gctattgcac 493081 cggcagactc attatcattg ctaatcctag cactagtatt actaggggta ggttggaact 493141 ttggtttact aacgggaact gcccttatta tagattcaac acatccatct ctacgtgcaa 493201 aaacacaggg aacattcgat gttttattag cactatcagg agcagcaggt ggagccttgt 493261 caggaatggt tgttgcacat tctagttata caatactatc aatttctgga gccgttttat 493321 cattgttact cattccagta gttatttggt attttagaag gattcaggaa aaagcataag 493381 cttatataac tgtctttgaa gaacctaagt agacattact ttaccggaac ctcctttttc 493441 tatttattat agtaaggagt tgacatggca ttagtggcat gtgtataact acacaattat 493501 ttgggattca gagagcatgt aatgaacgga agagataatt atttatcact tttattattg 493561 tacggtgttc ttgtggcatt aagttcagtc aattttggtc taactgtttt ctttttgttt 493621 tcatcacctc tccatattat taacaaacac gaaaaggatt ttaatgaaaa taaaatgatt 493681 agcgtatgta tctctaattt tcaaaatgaa tgaatagtcc tttttaagat ttacacactt 493741 attctccaag gaaaaatgac tcaatttttc gattttttat gtaaatcaaa aaagaatcat 493801 gttagagtag gtgtgctgaa aataattcaa aaaattattt tgcgatatga ttaaagtaat 493861 attgccagag agtttcaatt ggacaaaatt gtaagtgttt aatacactgg ggctgcaatc 493921 aaatatgcac ctggaatcaa ttgctaaacg ggggagttta tatgaacaac aagaaaaata 493981 tctttgatat tgttatgtac attattttcg gtgtgttaag tctttttcta gttgcaaaaa 494041 ctgattatgg cactggagtt ttagtgtttg ttgcaatttt atacctcgct gttattgctt 494101 ataaaattaa gcaagtattt agtaattcag attcttaagg tgtaacacaa ggaggatttc 494161 aattgagaaa gaaaagagtt attacttgtg ttatggctgc atcattgact ttaggctcac 494221 ttttacctgc aggttacgct tctgcaaagg aggactctaa gacaacccct tcttacgaag 494281 aactagctct acattacaaa atgaaaagtg aaaagatttc atcgaacggg aaattagttg 494341 aaattgagta tgtgagtgga aatgaaactc acaaagttca gatgaacgga aataatcata 494401 ctgtaaaagt cgatggcata gaacaaaaag gtttaaactt tgagtatgat gaaaatgttg 494461 ctaaaagaac aaattatgaa aacaataatt tgaaatcaaa tgaattcaca acacaggctg 494521 caaaacctaa aaagggatac cattatgtgg ggactttatc tgggcataca aaagcagcta 494581 aaaatgcgtt atcagttaca atgtcattag tcggtattgt ccctggcttg ggatggggga 494641 gtaaggctgc cactatttta ttctcttatt gggcaaaaga acaaatccct gatgcgtatt 494701 ataaatatga tttatacgaa aaaggagcaa tgactgatag ttggtatcag tatgctacag 494761 ttcaattttt tgaagataaa gctcataaaa agaaaatggg caaaccttgg acaagtactc 494821 ctgcaaaagt agatttacct aatagctaat tttaaaatca ctttgtcttt ataaaggaca 494881 aagtgatttt ttgttataca gaagtaaaat ccctcgtctg aggaatcttg gaaaaaactt 494941 ggttcaattt tgatataaca tgtttttttc ttgctaattt agtttttcta tgtatcgcta 495001 cacattctaa ataataagat attagccgga cggttgatgc caagctcaaa agtttatatg 495061 gaagtcaaag cataaaaaag ggtgttacaa cgtgtagtct tctttttatt ttgccaacgt 495121 aacaagtgtg aaagtaatga tttgtaggat cagttaagaa aggtttaaga ttagatattg 495181 aaaaatttta tatattttca ataaaatact ggtactataa taaatgtata cagattgtat 495241 ggagatgtaa ttaattaaaa aggagttttt taattgcgtt ggagtaaatg gttcaatgtt 495301 ttttgtatag tagcattggg atcaatatat ggttataaat tatttactaa ccaagaagtc 495361 agtactactc gtttaataat agcttctgta attgtgttgt ggaatattgt tggacttttt 495421 agcaaagaat cagtaaaaca agcacagcaa gcaaattaaa agtcataaag ttgggaaaga 495481 aggatgttac ttatgtagta tccttcttta ttattccttg aaaaatgaaa caaattggag 495541 attacagctt atataatcaa ttgaagtcgt tgattatttt catgaacagg agatttaatg 495601 ctttctgatg aaatattatc gtatgaatgt tgcaagagga aacgttactc aaagattaca 495661 gggatgtgat gaacactcct ctttatcgca ctcacctgac cccaaattgt tggggaaggg 495721 caggtacgga agatagagta ttttttcttc gtaacaaatc gaaaaggttg gataataaaa 495781 aacttataat ctaaggcggt atatagttgt gaaaaaggcg ttatttctta tattagacca 495841 gtatgcagat tgggaaggtg tttacttagc atctgcatta aatcaaagag aagattggtc 495901 ggttcacact gtttctttag accctattgt aagctcaata ggtggtttta aaacatctgt 495961 cgattacata atagggttag aacctgcaaa ttttaatttg ctagttatga ttggcgggga 496021 ttcctggagt aatgacaata aaaaactatt acattttgta aaaactgcat ttcaaaaaaa 496081 cattccaata gcagcgatat gcggtgcagt ggattttttg gcgaagaatg gtttgctgaa 496141 taatcatagc catacaggta attttgttta cttatggaaa gattacaaac aatataaacc 496201 gattagcagt tttgtagaga aacaagcagt aagagataaa aatttggtta ctgctaatgg 496261 aactgcccct attgaattta ctaatttaat tttagagatg attgattttg atactcctga 496321 gaacatagag aaaatgatgt atatgaatcg ttatggtttt tatcattttt gtgataaata 496381 tggaaatcca tttgttgatt aatttgctgg aaatgatttt cccgaatagg gggctttgcg 496441 attgagttga atttcctaat aaagcaaaga aagatgattt gaggtcaagt ttaacaaata 496501 atgccatcaa tattaatttg cagttatttc cgattcctga tataataaag aagaattatt 496561 tttgttcggt gtaaaggata gtatgaagat tgacttttcg tcttgatgat actttgggca 496621 aggatagtat atactgtgtg gttacacact aggaggcaac aaaaatggaa caaggtacag 496681 ttaaatggtt taatgcagaa aaaggttttg gctttatcga acgcgaaaat ggagacgatg 496741 tattcgtaca cttttctgca atccaaagtg acggattcaa atctttagac gaaggtcaaa 496801 aagtatcgtt tgacgttgag caaggtgctc gtggagctca agctgctaac gttcaaaaag 496861 cttaatcttc aatcgtttat acaaacaggc tctttatata gggcctgttt ttttatgtct 496921 atatcatact caataaaaaa ccctactcaa cgttcgagta gggagatgct acaaggtaat 496981 agaaaaagat ttaaaacttc aaaggtttgt ttacagtata acatactgga ttgacaatat 497041 gcggaatgta tataaattat ttaatgtttt gttcaaatat agataactga ctcttttttt 497101 cactaacctg ttcgttcatt taagtaagat tagatgaatt ataaaaatgg tttcatctaa 497161 atgttatcaa ctcgcatatc tcttttatga gaagaagata aacaattatt attcaatgtt 497221 gcagtggata taagaaattc ttaaaaataa tgaggagatc gattgttttt ttctcctgga 497281 aataatcact tagagatacc taaaacaatg aaagccctac ctctcttcca tccttacggc 497341 tccttgtccg tgccagtgtg aatcaggata ctaaaaaaag tgactatttt attgagtttt 497401 ttggtaaaac ttcaatcttc gcagaagaaa tgtaaataat aaaaatggat tagaatgtag 497461 gaataacaaa agaggtcgtt aatgttctaa acataagttg gagaagattt gcttttcatc 497521 ataatattcc gaaatatctt ttgggatgta tctaaccaaa actttttatt tgtttttcag 497581 tgattccttt aattacttcc agttcactaa tcaaaaattc atatgcatta tccagcattt 497641 ttttttcgct tgcattaagt gctttttctt tcttcatacg cattaaatca cgtacaactt 497701 cagcaccttc ttgtatttca cctgttttta ttttgtccgt gtttattttg tacctttgct 497761 tccatggcag taacctatcg gattctccat gctgaaaaat gtgcataatg tgttttaatg 497821 caagtatatc ggtaactggt cgtatattcg aactcaatat tttactcgtt ggaatcataa 497881 ctgtcatatt actgattgac attcttatga cataatactg ttgtttttcc tctaagaatt 497941 ctttttcttc tatggcttca attatacctg ctccgtgcat tggataaaca atgttatcgc 498001 caatttgaaa catatcatcc acctccatat atggtatcct tcttaagatt accatatatg 498061 gaggtgtaat atcaaaattt taataataac atgatcgaat ttttgatgtc aataactttt 498121 ttgaaaaaac agatcaagca aaaacaatag ggaacgtgtc ggatttccaa tcaggaaaag 498181 gtcaattgat ccgtgtgagc agtttttcat tggctcaatg acattacaga aatgatttga 498241 gtagataaga aagaacgata ttcgtgaaat gtcagctaaa aatatttaaa gcacatgatt 498301 aagttctaat ttctttaccg atttgatatg gataacggcc gacttactta atgatgcatt 498361 ttcacttatc ttgcaagcag aaaaaggttt gttgataaac atttagccac caaattggca 498421 ttattatcag ggaaattgac aaccttcaaa tgggtattga ggcgagaaga aaaataaaga 498481 aaggagagat tataaatgaa gaccagaaca taaagaagta aaggggaaag aacaaggtta 498541 attgaaaagc aaactatata aaatagtttg cttttttttg ttatgacttc acttcttttt 498601 ctttctcttt aatgactaat aaaacaccgc tcagaattaa aaacgaacct atccaaaatg 498661 tcccgcctat ttgttctcca agcagaatcc atccgagtaa ggttccaacc agaggctgaa 498721 aaaagaaaaa gaggcctcca cttgaggcat ttaataattg taagccgtgg ttccacaata 498781 aaaatgcaca agctgttgaa acaattccca aatacaaaag gccacctaga attttagggt 498841 caagcagtag tggcgtaaaa atcgtgctag gggagtacca ttaacaggga ctccatttat 498901 taatagaata aactttatga attcattttt ttgtatgata atggcgtcat attcatcgct 498961 tgttgaaatt tacttatgaa ataactggta ctgttaaatc caacttgata agacacttct 499021 gtcacattgg attcagggtg ttgcagtaat aataagcttt tttgaattct ataatccatt 499081 acataacgta atggcgtctt attcagcatt cgtttaaaat aacggcagca ttcagaacgg 499141 ctcagttggc cagcttttgc aatgtcctct aatgtgattt tttcaacata atggagatgg 499201 atccagttta acatttgttt cattcgatga ctttttatca tttcagattg atcgtactct 499261 aattgaaaac cattaacgac caggtttttc cacattaacg ttaattgcat cgtaatgtca 499321 atctcataga gcgatgtctt ttgttgaatc aattgattta tttttttaac agcatctaga 499381 atattttttg cccactgttg atttccagcc aaaaataaat agggcaaatt ggttgaaaac 499441 atatagggct gaacatagct tgaatacagt tcctgagata aaacgaaatg gggtgacaca 499501 ttcaagcaaa tatacgtaca atccgagcct tccttttctt cggccatgtg caggtagccg 499561 ctattgataa ataatccatc cccttcgtga acctctattt tttcttcatt tatttgaaag 499621 agagctatcc cttttagtat caaaacaaat tggatttcat catgccaatg aagcggaata 499681 tagccattta tattttgatt gatcgttgtc ttgtagcagg caactggcaa ttctaccgtt 499741 cggtgctctg ttaattcttt taaattttga tcgatcacaa aattcttcat tctgacttca 499801 cacctcaata tatttatatt ttttcattca atttgagtat tttttatcat gttttgcatt 499861 tattataaca ctattattat atttattagt gaggagtcat gtatgaatac ttccaataga 499921 agaatgggat tgttctatgt tatcacaggg gcgacatgtt gggggattgg aggcacagta 499981 gccaaaaaac tttttcaaga atatcaaatt gatgtcaatt ggcttgtaac gacacgcttg 500041 cttacggctg gaatgttact tttaatgctg caactgttca gaaaggatcg ttcccaggtt 500101 attgaggtgt ggaaacacaa agcgtcggct ggccagcttc taatttttgg cctattggga 500161 atgctagctg tgcagtacac atatatggca tccattcaac atgggaatgc tgccgttgct 500221 acgttattgc aatatttatc cccagtaatc gtcattatct acacgctgtt gcgaaaacaa 500281 acggttctta ccaaacaaga tatcataact gttgtacttg ctttagtggg ttgctttttt 500341 ttgttaacaa atggttcaat gtctcaactt tcagtgccgg cagctgcagt agtatgggga 500401 gttttatcag gattcgcggc agctttttat actttgtatg ccgttggttt attaaataaa 500461 tttgattctc ttgtcgttgt aggttgggct atgattattg gcggttttgc attgggtttt 500521 atccatccgc catggcaact ggattttcaa cgattaactg ctgaggcgta tgcatatatc 500581 ttattcgtga tattatttgg aacaatgatt gcgttctggt tcttcataaa aagcttggaa 500641 agcctctctc caaaagaaac aagcctacta ggcagtctag agcctctatc agctgttgta 500701 acaactgtcg tttggttaaa agcgccattt ggttcttttc aatggattgg tgctatttgt 500761 attataggga taactttaat attggcttta cataaagagc cttctatgga gagtgaaaaa 500821 tcgatattaa agattaggaa tcatgcaaat cgggatatat aggggctttt tttgcttaca 500881 tgaccggtcc ggcaatgaaa aacactggtg gagtttgagc cctctcggca gtatcaaaaa 500941 taccaagggt tttgacgccc taggtatttt ttcttcaaga accttcaatt tttcttctct 501001 gattgaaaaa cgtattactt ttttgtgatt ggtatccaaa tttcactttt aaaagatggt 501061 gatgttacat ccttatgctc gttccacaat atttctggac cttctatttg ttcgtaattt 501121 gacgatggaa accattcgga ataaatgcgt ccccatactt cttgcagtgt atccggaaat 501181 ggcccgattg attcgaatac agcccatgtt gaggcaggaa cttcaagccg tgagaagtta 501241 tctggacacc gtttcgttgt ggctgcgcca atatagtgat cgagctctcc gttttcctct 501301 gtccgacctt cagaaaaatt cgtggatgca ctaatgaggc ctgatggtgc tacattagat 501361 agctctttta gtttatttat tgctttttca tctaaacttt cccacataga tgcaatttcc 501421 ggattaattc ctttgaaaat aataggaact ctttttttaa tgccaacgat gcgaaatgcc 501481 tctttttctt caatacggta gttcatttca tttcctcctt taattgttag ctggaaggtc 501541 attcgtggat aagctttaag ggaatggcca ttaaatctgg cttttgatgg gtttatgcca 501601 tgtaaatttt ggaatgcccg tgcaaaagaa tctggtgagt tataaccgta ctttattgca 501661 atatcaatca cttttacatt gctgtctttc agttcaaaag ctgcaagagt aagacgtctg 501721 cgacgaatat attccgataa tgaaatacct gcaaggaagg aaaacatcct tttaaaatga 501781 tattcagagc agaaagcaag ctttgctgcc tcttgaaaat caatatcatt agtgaggttt 501841 tcttcaatat actttaacgc cctattcata cttttaagca aatccattta tttggcctcc 501901 tttaaccaaa gaataacagg agtgaaatgt atttatccga cattctgtgc acagttttgc 501961 aggatgactt atatgaaata aagtaagtga ttcacttgta tttgtacagg ttttattgaa 502021 gcatgctgtt cataaaaagg catcaataaa agaaagttat aattgtctta taaacggcac 502081 attcatataa ttgagtgaaa aaggatgcgt atcatgccta tcaattcttt tgaaaattat 502141 ccgatgagct ggaagccatc gattgataaa gctgaaaagc ctatttataa agcacttgca 502201 gggcaattgg aacaggatat tttaaacgga gttttattac ctggaacaaa acttcctcca 502261 cagcgagaat tggccgatta tctagattta aatgtgagta cgatttcaaa agcatttaaa 502321 gtgtgtgagt taaaagggct gctgagtgcg actgtaggga gcggcacatt tgtatcgtat 502381 gatgcgttgt cgaatgcgta tttacttgag gatactaagc cgacacattt aattgaaatg 502441 ggagcaatac ttccagatca cgcttcatat gagcccttgt tataccaact gaaaaacatg 502501 gttcatgagg aggattatga aaaatggttt agctatggcc gggcaggtga aagcctttgg 502561 caaaaagatg cagctgtaaa gctcatccaa agaggcggat ttgaaacatc cgttgatcac 502621 attttatttg caaatggagg gcaaaatgcg attgcagcga cattggcgag tctttgtaag 502681 cctggagatc gcatcggagt tgaccatcat acgtaccctg gattaaaaac tgttgcatca 502741 ttgcttagtg tgcaaatcgt accgataaaa tcagaaaacg atgaaatgag tccggagtca 502801 cttgaatatg cgtgtaaaaa cgaaaatatt aaaggtttgt atttaatccc ggattatcat 502861 aatccgacga cttcctttat gtctgttgag aatcgaagaa tggttgcaga cattgtaaag 502921 aaatataatc tgtttgttat tgaggatgca tcgtaccatc ttctcaacaa aaatccgctt 502981 ccggcactcg cctcattcgc accgcaacag gttattcata ttgcaagttt atcaaaatcg 503041 ttagcgccag gcctgcgttt ggcttatgta gcagtgccga gacaatataa ggagccaata 503101 tcaaaggcgc tttataattt aaatataact gtttccccgc tattagctga acttactgct 503161 cgcacgattg tatcaaatca atttgaagtc ttaattgaga gtcatcgtga acaaaccatt 503221 cgcagaaatc aactcgtaaa ccgatatgtt gcgggatata catgtttagg tgttgaaaca 503281 ggcatttttc gttggttgtt gttaccgggt aaaatgtctg gtgccgaatt tgaagaattg 503341 gctgctcgac ttggcgtgca agtgtatgcg gctgaacgct ttgtagtggg aaatagttgt 503401 cctgaaaggg ctgtaagggt ttctgtctgt gcaccaaaaa cacttgaaga gcttgaacaa 503461 ggattaatga tcctgagacg tttgctagac gatcttacct aatattgttt gccatacaat 503521 tatgacattg tatggctttt ttgtgcgtgt tatgatgatc cacatctaga gggaggttta 503581 tacaaaattg gcttttagaa aggaaggtca gatgatgtta gacaaggaca gcgtaaaagc 503641 aatagatgtt caaactgctt cattacagag ctacatcagt tcaccagaaa aacaaaaatc 503701 gttatacaag cgtacactat tcgttgtgag tatctcacaa atttttggcg gtgcggggct 503761 ggcggcagga gtgactgtcg gtgcgcttat tgcacagcaa atgcttggca ctgatgcgtt 503821 tgctggtttg ccttctgctt tatttacttt agggtcagca ggatctgcat taattgttgg 503881 aagactttct caacgttatg gccgtcgaac aggtctttca gctggcttta tgattggcgg 503941 acttggagca ataggcgtta ttatggcagc aatcataaat agtattttct tgttatttat 504001 ttcgttgctt atttacggtg caggtacagc cactaattta caggcccgtt atgcaggtac 504061 agacttagca aatcataagc agcgagcgac tgctgttagt ataaccatgg tttttactac 504121 atttggcgca gtggcaggtc caagcttagt gaatgtgatg ggggatttcg ctctttctat 504181 tggtgttcca tcacttgctg gccctttcat tttagccgca gcagcatata tgttagcagg 504241 tgtggtcctt ttcattatgc ttcgtccaga tccattagtt atagcaagaa caatagaagc 504301 ggcaaatgaa gagcctggtg ataaaggaca tttggcggca actgagcata cagaaaacaa 504361 aaaagggata atcgttgggg caacggttat ggttcttacc caaatagtaa tggtagctat 504421 tatgacaatg acaccggttc atatgagaca tcatgggcat gacttgggtg cagtcggtct 504481 tgttattggt tttcatatag gtgctatgta tctcccttca cttgttacag gtgttcttgt 504541 agataggttg ggacgtaccg caatggctat ttcctctgga acaacgttgc ttttggcagg 504601 tgtaatagca gcatttgctc cgggagaatc tatgattctt ctcgtcattg ctctttcttt 504661 actgggatta gggtggaatt ttggtttgat aagcgggact gcccttattg tagattcaac 504721 tgatactgcc acacgagcta aaacgcaggg gacagtggat gttctgattg cgttgtcagg 504781 agctgctggc ggagcattat ctggaatgat tgtggcaggt tcaagttacc tcgcattatc 504841 acttattgga gggattttgt ccttattact cattccggtg gtggtatggt ctaggggccg 504901 ctaaagggta ggattgttta atttacatta atttgttata ttgttagata aagtatattg 504961 cagcatctaa tattctaacg aactatagtt gctccattaa atctattata aagatttgac 505021 caggattcct tatagctgtg tcactcactg catattcttt aattgaatca cataaaatgg 505081 ttatcggatt tgaaaaaggc aggattactc gctttaggta aaggagtcat aacgttgtta 505141 aaaaggtttt ctcttgttat tgttacacta atgatgtcta tcgttgttgt tttagcggct 505201 gctaaagagt cgcctggaga tcatgtcatc tcatttgatg aacctattat cttgatgatc 505261 tcaattggaa tcgttgtatt tttattgatc cctccattag tcatgtcctt ttttggcaat 505321 ttggttgtaa gaataatatc tggtgtatac caatgtttta tcgttttcac ttttctgggg 505381 ctcattccaa ttggatttct tattcccaat ggctttttga caattctagt ttctattgca 505441 ggaactttag tcagtatagc tagtgttgcc gtaaccttat gcattggcaa gaataaaaaa 505501 gatatataat catcgaattg ttattttttc agattgtcag tgaaataatt atacaaaaag 505561 agaaggcttg tgggccttct ttttttgttg ttgcatcatc cccactttga gcttaatcta 505621 ttgaataata agagaaggaa cctatagaag aataaaataa ataccgagat gtcaaaaata 505681 aaactggact tcattattgt gaattcacgt aaatgtaaaa agattggaaa gaggggaatt 505741 ccttcatgac aaatagcaga acaaatccga aggttgatga atttttaagt aaagcgaaaa 505801 agtggaagga agaatttgag aagttgagaa ccatcattct tgactgtgag ctgactgaag 505861 attttaagtg gatgcatcct tgttacacat atcataataa aaatattgtt ttaatacatg 505921 ggtttaaaga atattgcgcg cttctgttcc acaaaggcgt cttattacag gatacagatg 505981 gaattctcat tcaacaaacg gagaatgtac aggcggcgcg ccagattcgg tttacaaatg 506041 ttcaggaaat aaatgagcta gaaaacattt tgaaagccta tattcacgaa gccattgaag 506101 ttgaaaaagc cggtttgaaa gtggatgtta acaaaaatat tgaattgaac attcctgaag 506161 aacttcaaaa taaattcgat gaaatccctg cattgaaaat tgcttttgaa gctttgaccc 506221 cgggacggca aagagcgtac actctttatt tttctcaagc caaacaatcc aaaacccgag 506281 aatcgagagt cgaaaaatat gtgcaaaaaa ttctcgatgg aaagggatta aaggattagg 506341 cacgccaagg ttcaggctaa aggaatagca tcatagcgta ataagatcat ttctatagaa 506401 gaaaaacaag catagtaaga tgcttgtttt ttcttaggac aacattcact tactgctgaa 506461 atgcttctaa cattgtatgc cactagacag cgttataaaa tattaatgca acacctagaa 506521 atctatccaa tgaaatagct caatggtatg gctcattaca tttagaatgc ctaggagaac 506581 taatagaacc ggaagatttt tagcaagtta ctacactcca aactttgttt ttgtattaat 506641 ataccttatt aaccattgtt tttagtcagg tgcagacaaa cgaatactga ttaatgaatc 506701 atcatgatat caatgagccg cttgattttt tcatcgtcgc ctgtatcaac gtacactgtt 506761 tttctgtttt ttatgatact ctcagtcact tcccgcatga cgcctttttc tatatcatca 506821 gcggaatccc agcgtaaagg cacattatat acatgaattg tgccatcccc attgccatga 506881 taagtgactg atccatccac taaacgagaa cctgccaact gggtcacatt ttctggatag 506941 ctggcacttg tatcatcatt aggattaatt ggctcgccag ccgcaatatg tcgaacattt 507001 aattcatcta tctcttgatt aggtccaagt tgaagccaaa ctctggcata ttcaattttt 507061 tccgaagagt atgctgccaa tacattgtct tctttgcttt tctcttctgc tgaagaggta 507121 tcatttgcag cttttgttgc ggattcttct gattctgtta ttggctccgc ttcatccttg 507181 cgtattttgg tgctctcttc aggctcagtg tgtttttcgt cagtttgcac agcagaagct 507241 tgatttgaag gttgttgtgc ttctccatcc ttactgtccg tacatccagc aagcaaaatc 507301 ataagcagca gggcagtatt gcaataacat atctttctgc gtttcttcat tttttcattc 507361 ctctctatta attcaggtca gcttcatata taagtttatg tatctaaata ttaccatgga 507421 atagatagga tgatattgaa aactgtttaa gaagaggaaa cgatcttgaa tagcatcgcg 507481 aaaacctaag aatcttaaga agttttgccc ctttttcttc aggtattgaa tgtaaagtgg 507541 gatataaatg caaacaaaaa cgaaatgcct tatccacctc gtgtcatggc agaaaaagtg 507601 ggggatttat tagagcggat ttgataatgg cggcaggtaa atgggtgttg acttatatgt 507661 ctaagcggga gactcaagtc tgctcgatcg catacaaaat accaagggcc agcaaccctt 507721 ggtattttta taccttcatg catttttgaa gtttatgctt aaaggtctgc cttactttgc 507781 aaatcgccga gctgctgcaa cgcacatgat aacggcgata ttcactgcta cgagtgccca 507841 gcccactttc tcgtgcagaa tcactgaggc aagcagcagt ccaaaaaaag gctggagaag 507901 ctggagctgc ccaaccgctg caattccccc ttgggcaaga cctcgatacc agaacacgaa 507961 gccaatcagc atgctgaata aggatacata tgcaagactg agcagtgcgg gaacgccgat 508021 cgccgaccat gagtccggcg taaaaaagaa cgacaatggc agcataagag gaagcgacag 508081 aacgagtgcc catgagatca cctgccaatt ccccagacgc cgtgaaagtt tggccccttc 508141 tgcataacca agaccgcata cgacaataga agccagcatg tacgcgtcgc caagcgggga 508201 tgaacctccc ccctgaatga gggcgaaacc tgctactaac aagctgccgg cagctgagaa 508261 aatccagaag acggggcgag ggcgttcacc cccgcgcagt acgccgaaga ctgccgttgc 508321 gagtggaaga agtccaatga agacaatggc gtgtgcggat gtgacatgct gaagcgctaa 508381 agctgtcagc aacgggaaac caatcactac gccgaacgct accactaaca atgaaatgag 508441 atctcttttg gcaggatgct gctgccggaa gatgagaagg agacctcccg ccagtacacc 508501 agctatcgca gcacggcaaa ctgtgagaaa taacggatcg aagtctgaca cagccaaacg 508561 ggtcgcaggc agcgagccgc tgaaaatgag tacgcctata aaaccattta tccagccatt 508621 tgttgttttg ttcattataa tcactccaca tatctttctt gttcattgtc tgtattttct 508681 taacaaaacc agcagctaag gattacaatg actataaact ggaattggcc ttttataaac 508741 agccagtttt cataaaaaaa tgcataccag ttaggagaac aacgcgcaaa tggatatcac 508801 gccttttttg aatagaactc tggatattcc gctttatcag cagctttatc ggtattttaa 508861 agaaaatatg catcggggcc gtattcaaaa aggaatgaag cttccttcaa aaagactcct 508921 ggcgaatcag ctttccatca gccaaacgac tgtagaacgt gcctatgaac agctcgctgc 508981 tgaaggttat attgtgagca agccaagaag cgggtggttt gctgattatc atgattctga 509041 ttttgcttat gatagaatgc caagcacaac acccattcaa caagaagcag aagaaaataa 509101 acaatggatt gattttcatt atgggaatgt agattcttct tacttccctt tttccgcatg 509161 gcgaaaaagc atggtcaata gcttagacca atatggacac gagctttatc ggccgggaca 509221 tgttttagga gagtttgagc tgagaacact cattgcagag tacctgtatc aatctcgggg 509281 ggttcattgc ggccctgaac aagtgattat aggtgccggg aaccctattc tgctgcaaat 509341 cttgtgccaa gtttttgagc cgaatatttc tatagggtat gaggatcctg gttatccaag 509401 agcacgcaag atttttgaag ccaaccgcat gaatattgtt cctataccag tcgatgatga 509461 gggaatctgt atacagaaga tcaaagaaca gcagccaaac cttgtatatg tcacaccttc 509521 ccatcaattt acgctgggaa ccataatgac aataaacaga agaattcagc tgctcaaatg 509581 ggcggccgaa aatcaatcct ttatcataga ggatgattat gacggggaat ttaggtacac 509641 aggacagccg gttccttctc tgcaagggct tgatcagcat aaccgtgtca tttatatggg 509701 cactttttct aagtctcttt tgccctcgct gcgtatcagc tatatgattc ttccttcgcc 509761 tcttttaaaa aagggtcatg aaatcacgtc cttatataag cagacagtgt cctgccacag 509821 tcagctaacc ctagctgaat ttataaaaaa tggagagtgg caaaaacaca tcaacagaat 509881 gagaaaactt taccgcaaaa aaagagccat tgtattagag gcagtgcaaa gggaattagg 509941 agagcatgtc agaatccgcg gagaaaactc tgggcttcgt atcttacttg acgtttattt 510001 gccatttggt gaaaaagagt taattgagaa ggcgaaaaaa catggagtaa aaatttatcc 510061 tgtttctctt tcttatcaac atcatcctcc tacaaaaacg gtctcgctcg ggtttgcagg 510121 ggtttctgaa tccgacataa gagaaggcat aaaaaaactg aaggctgcct ggaagatatg 510181 agggagcttt cagtttagca aaacggccaa gtgacgacta agtgttgaga gctgttcaat 510241 attttttaag tatatgatga gtgcctgcag tccaggccac gatacgtctg tttagcgaaa 510301 aacagaattt tttatttgct cctcacagtg ctaaaataaa caaaatagac aattgaaaaa 510361 atagaggtgt aagaatgaag ttagatgagt ttacaattgg ccaggtcttc aaaacgaaat 510421 cattaaaagt atcaaaagat gatattatgc ggtttgcggg tgaatttgac cctcagtata 510481 tgcatgtaga tgaagaaaaa gcgagtaaag gcagatttaa tggaattatc gcttccggca 510541 tacaaacact ggccatatct tttaaacttt ggattgaaga aggtttctat ggagacgata 510601 ttatagccgg aacagagatg aatcatatga cattcataaa acccgtatat ccggatgatg 510661 aattgtttac aattgttgag gttcttgata agcagccaaa gagaaatgaa ttgggaatac 510721 tcacagtatt gctatctact tataatcaaa aagaagtaaa agtgtttgaa ggtgagttat 510781 ctgtattgat caaacgataa ctcagaaagc ccgcttttcg cgggctcgat tgaagcagat 510841 gggtgaaaga tgttagcggg tttcctttga aaaataagag gttaaaacat cataaacaat 510901 aggcaaagaa gtaaatccct catcttctag aaaatgacct ccgtgctgaa cttcatataa 510961 cgcagcatca atttgttgtg ccagatcctt gctgaatgaa aaaggcacaa tttggtcgtc 511021 cttagaagca atgacagcac ggtgcttcgc ggactcgatg attttttgat gatcaaacga 511081 tccctgtgta aattcatcta acatctgtaa agtgggcaat gatttggcaa agccggaaac 511141 aagtatgatt ccgccaagct gttttcgtaa ttgaagatgt tccaaaaatc tcaaaatggc 511201 ggggcaacct aagctgtgcg caaccaaata cgtattttca tgtaaagtgt gctgatataa 511261 agagagtgta tccagccaat cctcaagtct tggctggagc ggattaggca tgtttaaaat 511321 gtctgcttgg accccatctg cgagcagacg ttttttcagc caagggaacc aatgatttgt 511381 tgaggaggct ctgtagccat gaatgatata gacttgtttt gtcattattt cctcctaaga 511441 aatattttca ttcagtataa aattcctctc attgggaaac aagtacgcac ttttttgtaa 511501 gtagctttac atatgaggcc ctccttgtgc cattccccac ttacacatct catctatgag 511561 gggatacaaa gatcgccctc tgtcagataa cgaatactct actttcagtg gggtgtgaga 511621 aacctcagac cgatgaataa ggccgtcagt ttgcaattcc ttaagctgtg cgcttaacat 511681 tttatgggtg atgaagggca tagccctttt cagctcgccg tatctcatcg ttttttcaca 511741 ccctaactca tagagaattc tcattttcca tttgccccct ataagagata aggtgtattc 511801 aaatggggct tgtttactgc ggcacaggct attcattgta atcaaacctc cttttttaag 511861 tatcatatca gaataaatta ggattttcgg tgttgaagtt tgagggcgat tcacgatctg 511921 aagtgaaagg ggccgcttgc tcaacaggcg gcacggtaca tgaatgttct aagtcaaaga 511981 gggttacctt actgttagtt actttattta aaaaaacgca tgtttttagc tgaaaatatc 512041 tattatggta tatttaaata taaagaaata tttgagaaat gaggaatggt atgaatacac 512101 ccaaaaaaca taagaaattt aaagcgaaaa tgattctcca aatcatcatg gttatcattg 512161 gaggaatcat agcggcatat ggactagaaa cagtgctcat tccaaacagt gtatctgatg 512221 gaggggtgac gggtcttagc atcgttggtt cacagctatt caacttgccg ctggggattt 512281 tgattgctgt gatcaacatt ccatttgtct ggttaggata taagcaaatt gggaaaagct 512341 ttgcattatt atcaattatc ggaatcgtat cgcttgccgc ggggacaagc tttttccacc 512401 acacacccgc tatcatagaa ggagataccc tgttaattac cgttgtcggc gggattatcc 512461 ttggattcgg aatggggctg gcgctgcgta atggcggcgc attagatgga attgacatgc 512521 ttgctgtgct gctatcccga aaactgccat tcggaacgag cgatctcatt ctattcttaa 512581 acctatttgt gtttattttt gtttccacag tatttggctt acaaggggca ttgctttcag 512641 tcattgctta ctacattgca tccaaagtga ttcatgttgt ggaggaaggc ttaagcggct 512701 ctaaaacctt tcaaattatt acaacccaac ctgaattaat ggtagagaca atacgtgatc 512761 aattaggccg aagcgccaca tataaagaag cttacggggg tttttcccac gagaaattta 512821 aagaaatcac atgtgtcatc aaccgtttag aagaaaccaa actaaaggaa attattaatg 512881 atattgataa aactgccttt gttaccgtgt atgatgtagc tgaagtgaag ggcagcaatt 512941 ttagaaatct taatcatcac taaaaaatag aatgaccttt ttaaccgtaa ctgacatgcc 513001 gcgggtaatt taatcaaaaa cacttttttg aggcttgtgg gtgaataacc ggtgaaggtc 513061 tgaatcacag aaataccaag ggcgtcaaaa cccttggtat tttttctggt tattagattt 513121 tatcttcagc tttacgtgct gcttcgagct tatcaatcct gtctttatat ttttctcccc 513181 agtccttcat gtgcaggata acaggttcta atgttcttcc aaactcagtt aaagagtatt 513241 cgacttttgg agggacctgt ttataaacct cgcggtgaat cacgccatcc cgttccaatt 513301 ctcttaattg tagcgtgagc atacgctggg taatttttgg gtatagtttt cgaaactcat 513361 taaacctctt tttaccgtca atgagatgat aaagaagaat gcctttccac ttacctccga 513421 tgatatctaa tgttgtctcc accggacatc cttcaaagtc atcagaagaa taatcaatgc 513481 cgagtttacg atttctcaag ctgttcactc ctaatagtat actttttgat actatataca 513541 ttcaatgtgc gtacttttta tattttaata tacatcatat aatgatgtca catctaagga 513601 atgaaaggaa tggatcatat gaaaacactc gtactcgttg tacatccgaa tatagaatcc 513661 tctcgtatca ataaaaagtg gaaagaagcc gttttaagtg aaccagatgt aactgtccat 513721 gatctttatg aaaaatatcg cgatcaacca attgatgtgg aatttgaaca acagcagctc 513781 ctggcccatg accgtatcgt ttttcagttt ccattatact ggtacagcag cccaccgctt 513841 ttaaaacagt ggtttgatga agtgtttacg tttggctggg ctcatggtcc cggcggaaat 513901 aaattgaagg ggaaagagtg ggtaactgcc atgtccatcg gttcacctga acactcttat 513961 caagccggcg gatataactt gttttcgata agcgagctga caaaaccgtt ccaagcatct 514021 gcccatttag taggcatgac ctatctgcct tcctttgccg aatatcgcgc caatacaatc 514081 agtgaccaag aaattgccga aagtgcgaat cggtatgtaa agcatattac aaatatagaa 514141 ttaaacccga aggttcgcct gcaaaggtat ttgaaacagc tggagagtgt cgatttaaca 514201 taaagattga tttttgaaaa tcctgtactc accaagcagg attttttctt gttcagcaga 514261 gggattttaa catatagcaa aaaaagaaga agccaccaaa aataagctat ttgcttggtc 514321 ctgactgctt atttttggtg aaatacttat ttctctgtga tgaaataaag caaagcgatg 514381 accggaaaag cgattccaat ccataatgct gtactccatc cgcctgaggc atatgcccat 514441 cctccaattg atgaccctat cgcaccgcct agaaagaaga tcgccatgaa taatccgttt 514501 aatcgactgc gaatttcagg cgccaacgaa aaaatagcac gttgactgag cacaaggttt 514561 gcagatacac ccatatctaa cagaatagca gcggccacta gaactgttat accgacgggg 514621 gagctgctct gaatcatgag cggcagtaat aaagagacaa cgacaacacc gagagcgatt 514681 ccagtggcaa gcctggttaa gcctcgatca gccaggcggc cgcctattgg tgcagtgact 514741 gcacccgcaa tgcccaccaa tgcgtagagt gctattgcct tctgagaaaa atgaaaatca 514801 ggaccggaca ataataaagg aacagttgtc cagaacaagc tgaaagctcc aaatacaaac 514861 gcatgataga tggcacggcg gcgtaagact ggagtcgtgc gcagcagctt ccacattgaa 514921 ccgagtaagg cagtatagtt tgtatttgct gttggttttc tggcaggaag cacttttgat 514981 aatacgatgg ccaggataac acttaccacg gcggacaaag cgaatattgc attccacccc 515041 cagatatcag cgactagact agatatcgga cgggaaagca taataccgag taataagccg 515101 ctcatgacat tgccaacaac ccggccgcgt gcagcgtctg atgcaaggta tgatgcaaat 515161 ggaacaagca cttgggctgc gattgatccc aatccgacga aaaacgcagc tgctaaaaac 515221 agtgttccat gcttcacaaa tgctgttagt gtcaaagccg ctgcgcttag aaggagcgat 515281 acaacaataa gttttttgtt ttcgataata tctcctaaag ggacaaggaa tagtaagccg 515341 gcaacgtatc cgatttgggt gagtgtgaca atcaatccag caccgcttgg agaaagtcca 515401 attgccttac taattaatcc gaccaagggt tgtgcatagt aaagattagc aacaatgata 515461 ccgcatgcag ttgcgagaag aagggttaaa ctgggtgaaa tcctctgacc tgcttgtttg 515521 tttccattag ccatatgaat gaactccttt ttaagtggtt ttttgagtgt aatcatgact 515581 tctcacaagt gattttataa actgaacgtt cagtttcgtc gattaataaa aataatatac 515641 taaacgttca gttttgtaaa tggatttctg ttttcttttt ttattcaatt taagtatact 515701 gaacgtatag tttatattgc gggaaggaat gatttatgtg cagagtaaac gagggcggcc 515761 gcgtgatgaa ggaacgcata aggcgattct ctctgcagcc tatgacctat tgctggaaaa 515821 aggcttcgat gcggtgacag tcgataaaat tgccgagcgt gcgaaagtga gtaaagcaac 515881 gatttataaa tggtggtcta acaaggctgc cgttatcatg gacagctttc tttcgaccgc 515941 gacggacagg ctgcctgtgc ctgatacagg gtcgtcagta caagatatag taacccacgc 516001 cacgaattta gctaggtttt tgacaagccg ggaaggaacc gttattaagg aattaatagg 516061 tgcagggcag ttggatgaaa aattggcaga agaatatcgc acgcgatttt tccagcctcg 516121 ccgcctccaa gcgaaaggcc ttctagaaaa gggaattcag aaaggtgaat tgagagagaa 516181 tcttgatatt gaagtaagca tagatctcat ttacggacca attttctatc gtctgcttat 516241 aacaggggat gaggtgaatg attcctatgt gcgtgatttg gtgatgaatg cgtttaaggg 516301 agttcaagct acctctgcta cagagagtat gtagctgata agaactgcaa aagctgcgga 516361 ttatatgaca aattggttcc atcgtacagt gaaatataag atttttgttg ctgagcggaa 516421 tcatcgaggg aaaagttctc ttatcggatg tcgaaaaaga agtcattcaa tcgtgaatac 516481 ataacatcat attattacat tccttttcat cgattggaac aagggttcta tacttcaatg 516541 gaataccgca aagttggagt atttaaacaa caggggaaaa tcgatggcca ttatgtaggt 516601 gtcatggcaa tggaaaaaat acttgcaatg taaacaggcc tctaaagaga cctgtttttt 516661 aatatccaga tgattgtcta gtttcagctt gggctctatg accactccca taactgaaat 516721 agtctaatat ttataccaga agggattgtt tatataaata aaagtttata taatgacggg 516781 ggcgctaagg aaacgcgggg agcgactcag gttttcgttt caaagttttg atccttaaga 516841 tatacggagc gctacatatg gaaacgtaaa ggggaatgta taatcatttg gcgtgtatat 516901 aacgatttgc ttatatattg atttgggaag gaggagctca tatgacgatt gatgttgcgg 516961 cgatgactcg ttgtttgaaa acacttagtg atcaaactag gcttatcatg atgagattat 517021 ttcttgaaca agaatattgt gtctgtcaat tggttgatat gttcgaaatg agccagcccg 517081 ccataagcca gcatttgcgg aaattaaaaa acgcaggttt tgtgaatgag gacagaagag 517141 gccaatggcg ttattattca ataaatggtt cctgtcctga gtttgataca ttgcaattga 517201 tcttacatca aattgatcaa gaggatgaat tgttaaacca tatcaaacaa aagaaaactc 517261 aagcgtgttg ccagtaagga ggcattagat tgacatcaat gattttggca gtattcatct 517321 ttttattaac tctagtattg gtcatatggc agccgaaaaa tttatctata gggtggtcag 517381 cctgtggagg cgcagtttta gctctaatag caggtgttgt caattttcat gatgtgttaa 517441 ctgtgacagg gattgtttgg aatgcgacct tggcttttgt ggccatcata ctgatatcgt 517501 taattcttga taatatcggt ttctttgaat gggcagcgct tcatatggct aaggctgcaa 517561 aaggatacgg tgtgcggatg ttcgtttatg tatctctatt aggagctatc gtcgccgcgt 517621 tatttgcaaa tgacggtgca gctcttatat tgacaccaat cgtattagcg atggtcagag 517681 cattacattt taatgaaaaa ttagtttttc cttttatcat tgccagcgga tttattgcgg 517741 ataccacttc gcttcctttt gtagtaagca atttggtcaa cattgtttca gcggactatt 517801 ttcatattac gtttattgat tatgcatcca gaatggttgt cccgtacctg ttttcgctgc 517861 tggcgagcat cattgtactt taccttttct ttagaaaaag cataccaaaa cgctatgatc 517921 tgactgaggt taaaaaacct gttgaagcaa ttaaagatca aaacatgttc agactgtcat 517981 ggtatatctt agggctgctg ttaattggat attttgcaag tgaatttttt tctatccctg 518041 tatcagtggt agcgggcagc attgcaatca ttttcttaat cgctgcgcaa aagagtccgg 518101 ccgtccatac aaagaaagtg gtgaaagagg cgccatgggc tatcgtattc ttttcaattg 518161 gcatgtacgt tgttgtgtat ggtgtccgaa atgccggatt aacggatgtc ctttcagatg 518221 tgattcaagc cgcagctgat caaggattgt ttgctgggac aattggaatg ggctttattg 518281 cggcgattct ttcttccatt atgaataact tgccgactgt tatgattgac gcattggcca 518341 ttgccggtac agatacacat gggatgatga gagaagcgct tatttatgca aatgtgatcg 518401 gttcagattt agggcctaaa ataacaccga ttggttcctt agcgacatta ttatggcttc 518461 atgttctttc gcacaaaggt atgaagattt cctggggcac gtattttaaa acaggaatta 518521 tcctcacgat acccacttta ttgatcacac ttgtcggcct gtatatttgg ctgctgataa 518581 tccattcttg tttctaaaag gacaaggtca ctatatcaag gaaaacaatg cactggtaac 518641 tcttgccgca gccaaatggc tgaagggtgg gggagaaaat accttggggc taagtggaat 518701 gtgtacagcg caggaatcga agctcaagga tgacatcgag tgctgtcaaa gcaatgaaag 518761 aagcagggat tgatatttca aatcaaacat cggagaaatt tgatgatccg gcaaaagcac 518821 acggaacaga agaagtgttt ccaaagggtc cgtgatgaaa ttggtgaccg tttaaaacag 518881 tttgctgtaa ctggggaata aagaatcgat atattcagcg ttttcttggg ttatataata 518941 caatgtgttg ttcaacaggt gtctgcgagc tgagtgcaga cacctgtttt tgtttttatt 519001 tgtctgagat tcgtaacagg gaagttattt agctggtgac agaggaaaat tgatttgtga 519061 acagaatcat gaaggagacg gtgttttaaa ggagttgtct gttttgcagg aattaacaaa 519121 aaaaaaatac agtagcttaa aaacaatgtt tgatgacaaa tattgtccca catttgtcta 519181 ttcaatatta gaccaaacca ttccgggagc tgtttatgca gatgatcaaa cctttcctaa 519241 atcgtttttt ataggaactg aatcaggcat ttattttatt gcgggagacc aagggaatcg 519301 ggattttcat gatttcattg caggatatta tgaagaacaa gtgaaatcat caaaacgatt 519361 taccttgttt tcttccagtg atacatggga tagcgtactg aaacccatac tgaaagatga 519421 cttaaaccaa atgagaagag ctgcattttc ttatcaacca aaatctttca aaaagacttt 519481 gcaactgcca aaggggcttg tattgaaaag aattgacgaa gacatcattt cacatagcac 519541 agcgtttaac agcgcgtatt atgaggagta ttggaattct gtctcacagt ttgcttcaaa 519601 aggttttgga tttgccgtat tacatggcaa tcacgtagta agtgagtgta cctctatatt 519661 tttagggcat aatcgagcgg aaatggatat ctatacactt gaagaatata gaggactggg 519721 gttagcttat tgcgtagcaa ataggtttat agcgttttgt atggaaaatg ggattgttcc 519781 tagctgggat tgtgatattt gcaacaattc gtccattgca ttagcagcta aactagggtt 519841 taagacggta acggaataca ctatttacta ctctggctaa ccttaatgaa agaaccttaa 519901 aaggagatac caaccgatgt tggtatcttt tttgttttag agttttttta cccttttagc 519961 agaaaaatgg gtgatgaaaa tcttattcat tttatttact tttaggtagg taaaacatac 520021 cccgccaact gtaaccactc cgcctagcag agagagcagt gtgggtatct cgccgatcca 520081 gagccaagat atgatcaagg ctaaagccgg tgtaacataa agtgaaaggg ttgcttctga 520141 agcaccgacg aatgaagtga catatgctag tgcgaagtaa ggaataaccg tcggcaataa 520201 tcctaagtaa acgatagaca aagttgcgct tattgaagcg ttcatcatct cttcgcctaa 520261 gcctggcaga aacacaagca taggtattgt tccgccccaa atggtgaatg taacgaatgg 520321 aataaaacca tattttttta tatagcgggc ttgaaaaacg aaataaatac tctccgaaaa 520381 tgctgccagc aggatgacca agataccgct cattgaatat gtaaagtctc ccgccccaaa 520441 tgcaatcaat aatacaccca ataaactgat catagagcca agccatttcg taaatccaaa 520501 atgctcttta taaaacaggc gggatagcat ggctgagaag atcggtgccg tagtaacgag 520561 taagcttgca actccggcac taactgtttt ttcaccgatg ttcagcaaaa tgtgatagaa 520621 tgcaaatcct aaaaacccta aaagaaaaat ggcaggaatg tctttcaagt cgggtaggcg 520681 catctgagtc aaaacagcaa aaagcaataa tgccatagag ccgattaaca aacgaaataa 520741 agcaaggtgt tctggcgtgt acccttcaag tcctgcgcga attcccggaa aagcagatgc 520801 ccataaacca atcatgagac tatgagatat cattatttga actgttttct ttcgcattcc 520861 tctcactcct ctttacaaaa accaaccagt tatttaatgt gtttctatac taataaagat 520921 ttgatgatat ggcttcaacc agttcaatag attttgaccc aaccaattta ttttaaggag 520981 accgattcta tgagctttcc agaagaaaaa aagatgaaaa agctccctaa gtacagacaa 521041 atcgttcatt ttattaaaga gaaaatagga aatggagagt ggccgattgg aagcaagatt 521101 ccaagccagc gcacgcttgc aaaagatttt caggtaaatc ggagcacagt gattacagcg 521161 ttagaggaat tgatggccga tgggctaata gaaggcacaa tggggaaagg cacagttgtt 521221 atcaacaaca catggacact gatggctaag aattctgctc ccgattggga tcaatatgtc 521281 acctctggca ttcagatgcc aagccgaaaa atcgttcaag agataaatca atcagaatca 521341 aatacagacc ttatacagct cagtaaaggt gaactttcag ctgagatttt tcctttggct 521401 gttatgaaag agatgatggg gaaggtatct caacacatgg aggcattcgg atatgaagaa 521461 ccaaaaggtt acttaccttt gagggaggca ttaagcaact atttaaaaac cattggaatc 521521 aacgtctcat cttcttccat tctgattgtc tcaggagcgt tgcaagcctt gcagctgata 521581 tcaatggggc tgttacaaag aggatcaacc gtttatcttg atcagccctc ctacctttat 521641 tcattacacg tatttcaatc agctggtatg aagctgactg gacttcctat ggataatgaa 521701 ggacttttgc ctgaaaatgt tcatttaaca agaggagagc ggggaagggc tatcttatat 521761 acaaatccat gttttcacaa tccgactggt attcttatgt ctaaaaagcg acgggaagaa 521821 atcctagcag taagtgagaa tacacagctt cctattattg aagatgacat ttatcgtgag 521881 ttatggatcg atgaaattcc gccatatcct attaaaacaa ttgataaaaa tggacacgta 521941 ctgtacatag gaagtttatc gaaaacatta agcccaggtt tgaggattgg atggatcgtc 522001 ggaccggaac cggtgattga acgtttatct gacattaaaa tgcaaacaga ttacggatcc 522061 agttcgctat cccagagagt agcggcagag tggtttactt ccggccacta ccagcagcat 522121 gtagaaaagg ttaggcagca attaaaggtg agaagagaat tggccttgag tgctttagaa 522181 actcatttga aagaagtggc gacatggaat atcccaaaag gagggttttt tgtctggata 522241 aaaatattgc cttccatatc aatgaaatta ctttatacta aagccttatc aaaagggatt 522301 ctgatcaatc tcggcagtat ctatgctcag gaaaaaggga attatattcg cttatcatat 522361 gcttatgcat ctcttgaaga ccttcaaaag gggatttatg agttgggttt aatgattaaa 522421 gaattggcaa gcaggtaact tttatatcct taaatggatg tttcactaaa aaagagatca 522481 agcctaatga tcgcttgatc tgataataac aagggttact agaatagacc aaatcatggt 522541 tcggtcttaa aataatcatg tctctgaacg aaaagtcttt ccgacttctc ttcctaaacc 522601 aaagtagtgt ctgaaattat agataagcgg gctccatttg gaagggttga tatggttttc 522661 gtccagaatg atactttcct cggcatgaaa atgtagtgcc tgcgtctcta caattgcgaa 522721 tgacgattca tattctggaa gccgaatgtg tttcacttcg gcttcgattt ggatagggca 522781 ttctttaatt cgtgttggtg atactgtttt tgattgtaaa ggcgttaacc ctgctgcctc 522841 gtatttttct tttttatatg taaatccgat ctgcttcttt aaaggcggta tactcttttt 522901 tccgctataa gatgaaattc tttcaacgtt ttcccataaa tccgggccag gcaagtttat 522961 gacacactct ttgtgtcttt ccaaattgtc gatggctttt cctcccagtc ctactccaag 523021 gattatataa tgtccaagag cccaagaaga agacatagga ctaatattag tggttccatc 523081 ctcattcaat gtggttagaa gaaatgtcga ggtaccataa tacatgatct tgggtttgat 523141 ttccttaaat cgacgagtgt cttgtttttt gatgtccaac gttttttcct ccttgtcacg 523201 cttacattta tattgtaaag gattaacatt tcaactatca tcgaaatatg aatgtaagga 523261 ggaaaatcat gaatcctaat attgcaaaaa tctcttcgtt gctatcagat ccctcgcgtt 523321 cttccattct tctcagtctg atggatggaa ggatacaccc tgcgggagag cttgcatatc 523381 tcgctaacat taaacctcaa actgcaagtt ttcacctgaa taaattgctt gaagcaaagc 523441 tgattagcgt agagaagcat gggagacatc ggtattacag attggctgac tcagatgctg 523501 caaatgtgat cgaacaattg cttcatattg cgcctaaagc aaaagtcaaa tctttaaaag 523561 agtcaaaaga gaaaaaggac ttgcatttcg cccggacctg ttatgatcat ttggcaggtt 523621 atgtgggcgt gcaaatggca cattcactag ttgagcaggg gatgttaaaa aaagttgatt 523681 taaactttga ggtgacttca gagggtgctt tattcttttc gaagttaggc atcaatgaag 523741 agcaacaacg gaataagagg agagcctttg cccgctgctg tttggattgg agtgaacggc 523801 agcatcatat tgcaggagca ttaggaaacg ccctattggt gcgcatgtta gaagaagaat 523861 ggatcgttcg tatgcctaaa acgagagcga ttaggattac acaaagcggg aaaatcgcgt 523921 ttgaaaagca cctaaacgtg aagatttagg attttgaagc ggaaacatca gatgatgagg 523981 cacgatatct aggaggagta agatttgttc taatcttact ccttcttctt attttgaagc 524041 agctcgattc cccattgcaa tagagatgcg gttccaactg tttatttgat taatgatcag 524101 aacaaggtca acatattgtt cctcatcata atgttcccgc acccgatgat atagctcatc 524161 aggaaccctt ttagatggaa tgagcgtgat gtgttcagat agttcgagag ccgctttctc 524221 ttcaggtgag taaaaatcac attcattcca agcatgtaaa cagtaaattc gctgttcagt 524281 ttctcccatt ttgcgggcat cggacgtatg catatctatg cagaaggcac agccgttcat 524341 ttgagagact ctgattttga ttagttctct cgtcgttcgg ttaattgagg attgtttcgt 524401 gtatttctcc atatccatca tgattttcat accttcaggt gcaatctcat agtaggacac 524461 tctttgactc ataaagcaag actcctttcc atagaatacc tagattgtat cccggtattg 524521 atcattttac caatgtgcgg tttgaatgac agctgtttca gcgtcttttg gaaagaagct 524581 tctttgaata aaaataaggg tagccagcaa tgatgagtgg agctgctaat gcaagcagta 524641 tccatgagcc tgattggctg tctctagtga ctctaatgaa tatataagta ccgatcagaa 524701 aatataataa agcacctaga aaccaataca tgttcattcc tctttttcct tgctttttgg 524761 ttgcgcattt ttgtctgtca tatggcttaa tcgatcaggg ttctgatttt ttaatacctt 524821 ttcggtccgg attccttttc tctttaatga taaaattgtg agatcaatcg atttcaatga 524881 tgatcattcc ttcaatgaat agtaagttcc ttatgatttt aaaggtaaat ttgaaaagat 524941 aaaacgtaca tagaggcaga acgttcatgt acgtttgggc aatgatcact tgttggaaac 525001 tctaatgttt ccctgcacct gatattgttg tgttccttct cttcctataa aatgattgga 525061 tacatgtatg tttgcacgtt gaaatatggg ttcgattttc atgaatctct attcggtgaa 525121 acaggtaaag gaagtggata aggtttgctt ataaggaatc cttttaaaga taaatattac 525181 tcacatgata ggcgggcatt aaacatgctt gcactcagag tgccgggcct ggcttttatt 525241 ctcatgatct atatagcctc tatcgtgctg caatttgttt ctgggggctg gtccatttta 525301 ttgctttatg cgtttaccat attaatcgcc atttttgctt tgcttcattg gcactcatat 525361 cgctgggtta agaaaagagt gattctgtat ttcgcggtac aaggtttgat cacctttgca 525421 cttgctaatc tcatgactgg cttctttata cttgtgatta tcggccttta tgcattttta 525481 attggacaaa ttataggaat ggcagacaga agaaggactt ttctcattct ttatctattg 525541 ctgctgctgg tcataaattc ggcgtatcac cttcataaag gtgaagtttt gcattttatt 525601 gttattgctg cgccgatcat gattgtcatc atcacttatg ccgcaacatt ttttgcccaa 525661 gtcgatgaaa aaataaaagc tcaattgact cttgaaaggc tggagctggc tcatcagcag 525721 gtagaacagc tgacgctgca gaacgaaaga cagcggatgg cccgagactt acacgatacg 525781 cttgctcaag gtcttgtcag tttaaatatg cagctggatg cgattcatgt tcatctcgcc 525841 aaaggcaaca cagagagagc gaaggaaatc atacaacaat cgatgaaaag agtgaaaagc 525901 acaatagctg atgcacgttc agctattgac gatctccgca gcaaatcaga agaaatcggt 525961 gttttaaaag aaagaattac ctcgctaatg gatcatttta tagagtcgac aggcatggct 526021 tgtttattag attacagatt gcatcaggtg ctggatgtgc gtacagctga aaactgttat 526081 tacatcattg gagaatgcat gacgaatgcg gcaaagcatg ctgaggcgaa aacaatctgg 526141 atatccattt gggatgatga aaagggaagg ctccatttaa cagttaagga taacggcaag 526201 ggatttgatg ttgaaaaagg aaagaaaaag agaggacatt atgggcttct tggcatacaa 526261 gaacgcgtca gggcaataaa tggccaattc aatatcaaga gtacaaaatt gaaaggaaca 526321 caaattgaga tcactgtacc aattcaggga gagatgcaag atgaataagg ttttaatcgt 526381 tgatgaccat cttgtcgtga gggaaggtct gaagctttta attgaaacga atgatcaata 526441 caccattata ggagaggcgg aaaatggaaa agtagcagtc cgtcttgcag atgaattaga 526501 accggatatc attctgatgg atttgtatat gccggagatg agcgggttag aggccattaa 526561 acaaataaaa gaaaaacacg atacccccat cattattttg actacatata atgaagatca 526621 cttaatgatc gaagggattg aattaggagc gaaaggatat ctgttaaaag atacgagttc 526681 agaaaccctt tttcacacaa tggatgcagc catcagagga aatgtgctat tgcagcctga 526741 tatccttaaa cgtctgcaag aaatccaatt tgagcggatg aaaaagcagc gcaatgagac 526801 gcagctgaca gaaaaggaag tcattgttct aaaagcaatt gctaaaggtc ttaaaagcaa 526861 agcgattgcc tttgatttgg gcgtctctga gcgaacagta aagtccagat taacgtccat 526921 ttacaataaa ttaggcgcga attcaagaac tgaggcagta acgattgcca tgcaaaaagg 526981 tattctgaca atagacaact aaactgcata tttgaaaatt gcccaaacgt acatgcccga 527041 atgtacgttt ttttcatttc attgtcaact acaatgagaa agaatgtgat caagcaatgt 527101 gttgaaagga gattatcatg tcaaaaatgt tatatacatt aggaggatgg gttgctcgca 527161 atcgcataaa agcaatatgt gcgtggatcg ttgtgttagt tgctgcgata ggccttgcag 527221 tgaccttgaa accaagtttt tctgaggata tgtccatacc tgacacacct tcggaaaaag 527281 cgatggatgt gattcaaaaa gaatttcctc atggtcctga taaagggagc atacgggtta 527341 ttttcggtgc tggtgatggg gagaaactta ctgggaagcc agcaaaaaaa gcaatagaag 527401 atacgttcaa agaaatcagt aaagatgatt ctgttgactc gattgcaagt ccttttgtga 527461 cagggacaat cgcgaaagat ggcacagttg cctatgctga tatccagtat aaatcatcag 527521 cagatgatat aaaggattac tctatcaaac acttaaaaga cagtttgaaa atggctgatg 527581 atgaaggatt gcaaactgag ctaagcggag atgtaccggg agcggagatg gagataggcg 527641 gtgtctctga aattgtcggc attatcttgg cttttgtcgt tttagccatt acattcggtt 527701 ctttattaat agcaggtttg ccgattttaa ctgcactgat tggtttaggt gtaagtattg 527761 gactggtttt gattgggaca caagtatttg atattgcttc tgtcagtctt tcattagccg 527821 gaatgattgg ccttgctgtt ggtattgatt atgctttatt tatttttacg aaacaccgcc 527881 agtttttagg cgaaggcata caaaagaatg aatcaattgc gagagccgtg ggaacagcgg 527941 gaagtgcagt ggtttttgcc ggacttactg ttatcgttgc actttgcgga ttaactgtcg 528001 ttaacattcc ttttatgtct gcgatggggc tgacagcagg gcttagtgta ctgatggctg 528061 ttttggcttc catcacactt gtgcctgcgg tcttatcgat tgcagggaag cggatgattc 528121 cgaaatcaaa caagaaaata gaaaaacaaa gcactgaaac aaatgtctgg ggacgctttg 528181 tcaccaaaaa tcctatcatg ctaagtgtat gcagcattct gattttgatc gtcattagta 528241 tcccatctat gcatttggaa ctgggcttgc ctgatgctgg gatgaaagct aaggataatc 528301 cggatcgccg ggcatatgac ttgcttgccg aaggctttgg agaaggattt aatggccaat 528361 taacaatcgt agcggatgcc acaaatgcta cagaaaataa ggcggaggct ttcgcagatg 528421 cagtgaaaga aataaagggc ttagaccatg tagcaagtgt cactcctgca atgcctaata 528481 aagaagggaa ctttgccatc attacggtcg ttcctgaaac aggtccaaat gatgtcacaa 528541 cgaaagattt ggtacatgat gtacgcagtt tatcagataa aaacggagta gatttgcttg 528601 ttactggatc aactgcagtg aatattgaca tttcagatcg cctgaatgat gcgataccgg 528661 tgtttgctgt acttattgtt ggctttgcgt ttgtattgct gaccatcgtt ttccgttcgc 528721 tgcttgtgcc gcttgttgct gttgcaggtt tcatgttgac gatgacagcc actcttggaa 528781 tctgtgtatt tgtcttgcaa gacgggaatc tcatcgactt tttcaaaata cctgaaaaag 528841 ggccgatact cgcgttcctg ccgattttat cgattgggat tctgttcggg ttagccatgg 528901 attatcaagt attccttgtc agcagaatgc gtgaagaata tgtaaaaaca aacaatccag 528961 tacaagccat tcaggctgga ttaaaacaca gtggtcctgt tgttacagca gccggcttga 529021 tcatgatctt cgtttttgca ggatttatct ttgcaggcga agcttctatt aaagccaatg 529081 ggctggctct ttcctttggt gtactctttg atgcctttat tgtaagaatg acactgattc 529141 caagtgtcat gaagctgatg gggaatgcag cctggtattt gccgaaatgg ttagacaaga 529201 ttattccgaa tgtggatata gaagggcatc aactgacaaa ggaaatacag ccggaaatag 529261 atcatgaaca aaagaaacaa atcagtgtgt aatagaaaaa gcagatcttt tatgatctgc 529321 tcttttgctt atggtagtat ttagaagatg aagtcggcag ttaaaaggag acgcttatgg 529381 cgccatcact cattttcgat atggatggaa ctttgtttca tattggcaga agctgcatca 529441 tactagcagg catcccagga gaagtgacat gattttttga ctttgcattc actacttgat 529501 gccaaggatc ttgagaatcc ttcttgaaaa taaaggattt tacaactgat catataagaa 529561 acctaaagaa acaagcacac aaaaccagct gcgggttttg tccaagaaaa atagagtcca 529621 taagagggac tctatttttt gaagtgcccg gctagaagca tattgcagga ctttatgaat 529681 gcaaatcact atcttataag cccttaccgt gaaatgcctg tttctgcatt gaaaaaacgc 529741 attacacgtt catttacgta agtgggttgt tccatcgata aaacatgtcc ggcattttta 529801 atgacttccg cctcaatatc tggaacgaat gaagaggctc ggtgcagggc tgagtgggga 529861 tcatagatga cttcatgttc accaagtaat aataggatag gaactcttgc tgaacgtaat 529921 tcctcatcgg taaaaacata cggaaatccg tcggcattag gatttggatt tcttgatcca 529981 tcctgccaca ttacccctgc cttaaactgc ttcacaaaaa tcgggtgcag cacattctga 530041 tcattcatca tccaatttaa gaatgtttca actccatttg acgctgtaag gccaagagcg 530101 tatttgtaga aatcgtgatg aaatggcaaa aacgtttctg ccggactcag tatagctgcg 530161 ctttttactc tctcaggcat acgtaaaagg aaattcatcg tatggagacc gccaagcgaa 530221 agtccgatca tgtgggactt ttcgatcccc agattgtcaa acacatcaag aagccaattg 530281 gcgtaatccg ttcttgtacc gcttacattc tcaggaatac tcttgttttt atcacctatg 530341 atatcaactg cataagttct gtatttactg ctccaatcgg cgatgttggg ataccacatc 530401 gtcgagctga ataatgctcc gtggagtaat acaagcggcg gggcatcctc tgggccgctt 530461 gcaatcacat gtgtttgacc aaaacgagta gatatataga atgatttaca acggaccggc 530521 caaagactaa ggctttcatt ataagtttga taatagcgga taccgttgtc acttaattcg 530581 ggaatactag atgaatggtt tgacatacaa atgcccctcc caattttgtt taaatgaatg 530641 tgccgtttcg tgatggggaa tctgattttg atataacaga ctttatttac aatataatac 530701 agttgttatt agacgtcaaa tccaagatga aaaggaaaaa aacgattgaa acagattatt 530761 gaaaatcaat ataacagaat attaacctcc tttgtggagc cgcttcatta aaaccgcaat 530821 ccaaatgcat gaatcacaaa aatcacaaca ggagggatca ggagggaagg cagcagattc 530881 agtgttttga acttcttgat tccaagaatg cttagacctg aactgaggat gagtatgcct 530941 cccacaattg tgatttcatt aataaggtct gtattgattg cgctctccat tacttgtgca 531001 aataaataga tggagccctg ccaggaaaat aatacaagtg cggcagccgc tattccaaaa 531061 ccaaaagttg aagcgagcac aatggaggtg atcccatcta acatcccgtt tgtcagaagg 531121 tatgtataat ctccatgcaa agcggcttca acagggccta atattgacag cgaacctata 531181 caaaataata agaccgcagt tgataagccc tctgctaaat tgcttttaga aaatttgttc 531241 accagcttgt tgaatcgtaa ttctaaattg atgatctggc ctagcaaacc tccaatggct 531301 aaactcacga tgaatagaat ggggtattta ctatcaggca aatgctgtgt aatggcgttg 531361 atccccagtg cgaccgcagc gaatcccatt gcctgcatca aaatatcctg gtattcatct 531421 ttaatgcctt ttttgaatat ccccccgatt atgcttcctg caatgatcat cactgtgtta 531481 aaaatcgttc caaacataag ctttctcctc caaaaatcat tcctgcataa aaaataaacc 531541 ctctagttag tagagagtca agggagatca aaacatattc atgagattat ttgatgggca 531601 gcaggatttc agtcacgtaa ttatctaggt tattcgtaat gccataatca atgagtgtga 531661 tttcgattga gtcccctgct acctcataat gatgttcttt catatatgcc agtaattttt 531721 tgtagtatgg ttcggcttct ggatgtgacc ctttaaacct aatttgcaga tattctcttg 531781 aaggaaagat gatttctgaa gaagtttttt cattttcatc ttcaagaatc ataaatatac 531841 tggaatattt gtcaaactgt tttgctttca catttgctgc agaaatggat aaaccaatct 531901 tgcctatgaa tatatcttcg tttacattca ggtgggttct caattcagct aacgaatgtt 531961 cgatatcatg gccgagaaca tattcatgct gcaaataggc cacacgcatt gcgggaagtt 532021 tgatttttga aatttgatgt aacggcatgt taacggcatc ttctatatgt gtgatgcgtc 532081 gggagatctt tcgttcaatg cgttccaatt ctttcttctt gcgatcaatt tcaacctgct 532141 ggctttttag taaatgaaga agagtgtttg tattttgaga gttataaaaa tcaagaagct 532201 tattgattgg caggcctagg gccctcaaat acttgatggt atccagccgc tcaaactgtt 532261 gggtagaata atatctatag ttcgtttgct catctttata ttccggtttc aaaaggccga 532321 tttcatcata ataccgaaga gcagagattt tcacattgaa taactttgac acttctccaa 532381 tcgaaaaaaa ttccttcatt ctaacaacct ttctgtccta tgattgatat acacacatta 532441 tatagtacgg cgagtactaa aggtaaagtt tgcagcataa agaaaaaact ccttctaaaa 532501 aggagctttt cattcttcga aataaggatt tacatggatg agcacttctt ctacatctga 532561 aaactgtctt ttgatttcat ttcgaatttc gcgggcaatg tcgtgtccct gcttaattgt 532621 caaatcatga tccaaagata aacggacatc aagcaattta tagtggccat gttctcgcgc 532681 gcggattcta tcaattcgtt ttacctgatc acattgaaaa ataacagctt tatattcctc 532741 tatcagctcg ggatcaacac tcttttccat gagcacatca acagacggcc tgattaattc 532801 cattgaaatc ttaaaaatga ggtaagcaac gattgcactg gcaatggcat cggcgtacaa 532861 cagataggac catccacggc tgtttccgat gatagccaac aggacgccga taaaagcggc 532921 aagagaggca acgatatcgc ctttatgatc gtacgcaatc gctataatcg ctttgctgtt 532981 ccattttttc ccttgcttta tagaataacg atataagatt tccttagcca cgtacgaaat 533041 cagagccgca aacaatgcgc tgtattgggg aacgcttggc cctttaacaa aggacagaat 533101 cgcttctatg aggatataaa cggatacgat cactaagata attcctacaa tcgcctcact 533161 aatgacttca gcttttccgt gaccaaaagg atggtcttga tcgggcggtt tattggaaat 533221 tccgatcact gccaagactg caatcgaagc aacgacatct gccgcggaat gtattccgtc 533281 tgcaaacacg gcttcactat cgcctaccag cccaaaaaag acctttcctg ccattaagat 533341 cagattggcg atcaatgcaa tcaaagcaac ttttctgctt atttgttctc tttcacttgc 533401 cattttttcc tcctataaaa ctgcacaaaa aaataggagt gctctatata cgctctccgt 533461 atcctttcct gtgtaatcac tttgtttatc ataccaattc aatttcgagt gggtctatag 533521 caacgttgtt tcctgtttac taataaataa ggtgacagaa aaaaagttgg agctatgcta 533581 aaaaggtcat acagcaaaca aatgagttct tatgtaacaa cagtgatgat tcgctattaa 533641 aatgctgccg tcagtgaaaa atttccacct aattttcaaa aacctattga catgagaaga 533701 tctgtatttt actattatct catattcaag atattttaat ttgagatatt tggtcggaaa 533761 gatcagcgat caagcgcaac tctaagtgtt caatcgttgt cagttctttt acacaatatt 533821 caatatgatt ttttataaca taatatctcg aattcgagat aaaagggagt gtagcgtaat 533881 ggctgaattt actcatttag tcaatgaaag acgatctgca agcaattttc tttcaggtca 533941 tccaatcaca aaagaagatc tcaatgagat gtttgaattg gttgcattgg caccatcggc 534001 ttttaatttg cagcatacaa aatatgtgac ggttcttgac caggacgtaa aggaaaagct 534061 gaagcaggcc gcaaacggac aatataaagt ggttagctct tctgcggttc tcttggtatt 534121 aggggataag caggcatatc aacaagcggc cgatatctat gaaggtttaa aggtattggg 534181 gatattaaat aagcaagagt atgaccacat ggtgcaagac accgtttcgt tttatgaaaa 534241 caggggagaa caatttaaga gagatgaggc gataaggaat gcttcacttt ctgcgatgat 534301 gtttatgctg agtgctaagg aaaaaggctg ggatacctgc ccgatgatcg gctttgatgc 534361 ggaagccgta aaacggattt tgaacataga cgaccaattt gaggttgtca tgatgattac 534421 gattggaaaa gaaaaaacag agagcagaag accgcgcggc taccggaagc ctgtgaatga 534481 gtttgttgag tatatgtaaa aggagcggat aaaaatggct aaaaaaacga tgggaattca 534541 tcatattaca gcgattgtcg gtcaccctca agagaacaca gatttttacg caggagtgct 534601 tgggcttcgt ttggtcaagc aaactgtcaa ttttgatgac ccaggtacgt atcatcttta 534661 ttttgggaat gaaggcggga agccgggaac aatcattacc ttctttccgt gggccggagc 534721 ccgccaaggc gtcattggag acggtcaagt tggcgtgact tcgtatgtcg tgccgaaagg 534781 ggctatggca ttttgggaaa agagactaga aaagttcaac gttccctaca ccaaaatcga 534841 gcgctttggg gaacaatatg tagaatttga tgatcctcat ggactgcact tagaaatcgt 534901 ggaaagagaa gaaggagagg ctaatacgtg gactttcgga gaagtaacgc ccgatgttgc 534961 cattaaaggt tttgggggtg caaccctatt atcagagcag cctgacaaaa ccgctgacct 535021 tttagaaaac atcatggggc tggagcgagt cggcaaagaa ggagacttcg ttcgttatcg 535081 ttccgccggt gatatcggaa atgtgattga ccttaagtta acgcctattg gccgcgggca 535141 aatgggggcc ggaacggtgc atcacatcgc ttggcgggct aacgatgatg aagatcagtt 535201 agattggcaa agatatattg cttcccacgg atatggtgta actcctgttc gggatagaaa 535261 ctactttaat gccatttact tcagggaaca cggggaaatc ctgtttgaaa tcgcaactga 535321 tcccccaggc tttgcacatg atgaaacaca ggaaacaatg ggcgaaaaac tgatgctgcc 535381 tgtgcaatat gaaccgcatc gcacacaaat tgaacaaggg ctgctgccgt ttgaagtaag 535441 agagttagat tgatttgaca cataaaaaat aaagaaacat atattcaatt gatgattgct 535501 ggatggtact gtcagcaaag aatcagataa aatcaaagat gaggagagat acaaatggaa 535561 gatgcaggac tgttgcttat tcgtataatg attggtgtgg tgtttttgtt ttatggcaca 535621 caaaaattat tcggctggtt tggcggatac gggattaaag gaaccggaca atggttcgaa 535681 tcaattgggg tgaaaccagg aaacgttgcg gccgctctat caggtcttgg ggagttagta 535741 agcggaattc tatttatttt aggcgtattc ctcccgcttg gagctgctat cataacaatc 535801 atcatgttag gtgctatcgt aaaagtccat ggagcgaaag gttttgcgaa tggcgccgga 535861 ggttttgaat ataacctggt gctcattgca gtttccatag gggttgcact catcggttca 535921 ggagcttacg ctttgcattt ttaatacgaa agtatgtaag aacagttgct gcttgtcagt 535981 aactgttctt ttattttcac attttcggca agcttgcagg tactctgcaa agcaaaaaag 536041 cggatatcat aaatataaat ctgtatagtg aatgatacgt attgatgagc ttggtcatga 536101 aaaacagacc tatttgaagg agtaaatgga tgaaagagat gacaggatta cattcattag 536161 tttctataga aaactttatc aaacagcaca aattcagttt tatttatata tcaaggcctg 536221 gctgtacagt atgtcacgca gttctgcccc agctcagaat agtattggat cagtttccaa 536281 acatcaaatt ggggcatatc aatgctgacg atgtagcaga ggtcgccggc agattttcag 536341 ttttcaccgt tcctgtgctt cttttgttca ttgatgggac tgagtttcta agagaagccc 536401 gttttgttca ttttgaacag cttgaacaaa agctgaaaag ggtttatcga ttatatgaag 536461 gcgaataaag gaataaggca aaaaaagaac tcaaatgagt tcttttttta ttcttcacta 536521 ggcgaagaag ggttatcaac ctgcccttga tcacttgtat cattatcaca acttgctgaa 536581 ataataattg aatgagaagg agagtaatct cctaatgtga aattcactcc gtaatttttg 536641 ctgttcgcag tatggctgtt ttgcaagttt tgtccgatat ctgtattggc gttttgtgtc 536701 attccattta tcgtgagatt tgagatgttg atttgagatc gcatgcttca aaaactcctt 536761 tcactcagaa gtagctgtca taaaggacgc tggcagtcta tttacttcta tgatattgcg 536821 tttttatatc attgcatcaa cataatggta aaaataatag cgagtgaatg atcatctttt 536881 gaagatgatc aacctatcag cagaaataaa gccgcctgat aaagaggcgg cagatcgtta 536941 tatgtcatct atgaatttga tgtatcgttt ttcgtttgcc tgaaggataa gatagtcgtt 537001 tttaatgatg agtaggagcc tatagcagcg tagccataaa accagcccat aaatacgcca 537061 gaaaagaggc tgtgtcgatg gcttatgaaa acagaaatga caaggcctgt tattaaggca 537121 actgacggta caaaagtttt ggggattttc aataatattt tgaggatttg ggttatcaat 537181 atgatgattg gaacagctat cacagcatcc caaaagttcg tgtgaataat tggaaaagcc 537241 atacggcacc tcatgaagtg tttatttctt aatttttacg ctaaaagctt ggaaagcagc 537301 tcttggatcg catatgttac attttgggct tgattggcgg agcttgtttg gcttaaagca 537361 ttggattcaa aaaccaaacc tgtattactc ccaccggaac cctctgttgt tttagacaca 537421 gagaacgggc tgatggaaac tgcaaatccg ttattaaaaa cgctgttccc ggatatcgaa 537481 tgaatataaa ctgggaattt catcattcat ctctcctctc tgttatgact gtttatacaa 537541 tatggtgtgt gagcagcagt tgcttaaaca aaacggcaaa aactttcagt aagagacaaa 537601 aacctgcaaa atgccacaag cgccttttgt taatgcagct ttttagggac gtttttttta 537661 ttttttttgc caacttcatc aaaaatattc tgattgccag actgggcttg tccgtcctta 537721 tttatgaaat cggggtgaat gagttttttc agatccctga ctgttaaagg cttggcgtca 537781 tcagttaatt ctattcctaa ttgcccgttt gcctctaatg tcgcaatttt gacatcttgt 537841 atagccgtaa cgccgtgaag ccttagctgc atttcaagct ggtcagctgt aagtctcatc 537901 ttctttaagt tttcgatatg aagctgtccg ttttcaatga cgatttttgc ttttccggtt 537961 aacatctttt caatggtgtt cgatttcatt tggatccatt ccataacgat gagtgtgctt 538021 gtgaaaattg ccgctgcaat taatgttttg aagaggctgt actcgatgat tggctgaacg 538081 ataatagttc cgatcgaaat catgacaacc gtttgagtcg acgtcatttg tgcgattgat 538141 ttccttcctg aaattctcag caaaatgacc ccggctacaa tgagaacaag agattcccaa 538201 gtgaaattca tgctaccacc tgaccaatga tgaattagat ttgtcatggg attggctttt 538261 cttccggcca atcgcaattt aatatatccg aaaggcagtc ggttcattct gtcctgaacc 538321 gaacaatatt tttggtatag atggatatat taagccaaac aatgatagca acaggagttt 538381 tttggccgaa acaatctggg aagcggggag cgccataaca tgattgaact tgaagttgtc 538441 attagaacgg ttgccagctt tggcttgctg ttaatcgcag aacgaatttt aggcaaacag 538501 acaatctctc aaatgacgat ttttgatttt attgcggcga tcacactagg ggcgattgct 538561 gccggattag cttacaatac ttcaataaaa ccgcacaata tggccatttc gtttagtatt 538621 tttgtgctaa ccatttttct aatttcgttt ctgtcgataa agaacaggaa gctgaggaaa 538681 ttttttgccg gagatccaac agtgctgatt caaaacggga agatacttga atcaaatatg 538741 aggaaaatgc gttacacact tgattattta aatcagcaat tacgggaaaa agaaatattt 538801 aatatcgaag aagttctttt tgccattctt gaaacgaatg gtcagctgac tgtgttaaga 538861 aaaccgcaat tccggcatgt gaccaaacag gatttaatga ttgcggtaaa ccaagaacaa 538921 aggcttccga tagaacttat tatggacgga gaaatcattg agaataattt aaagcagaat 538981 cgtttgacgg aatcctggct tttggaagaa ttgcgaaaaa gagacataaa ggtgaaagag 539041 accgtgtacg cagtgctgct gggtaatggg gatatttatg tggatcaata taaagaccat 539101 atatcagtcc ctatggataa ggaatgaagg aacaatcaat cttaaagccc cttattgaac 539161 gcaacggttt caacttgtct tgggtacgaa atatgcagaa gcccgtttaa cagctgaatc 539221 tgtaacaaat gagtttcagc ggcttcggga agctgaatga ttcgctcaat ttctccgtaa 539281 taccgttcac gcagcacttc catttcggct ggaaaaacag gcgtgatcgt tcctttgatc 539341 agcagctggg ttttagacag taaacggatc gttaattctt cctcatacac accgggcatt 539401 tccacaatga taaaattata ttcctcatct tgataaaagt cgtaaacaaa cgtagaagct 539461 tcggaatcaa aaaaatgttc cggggcttta tatttgagca catttgtcca aaagtcactt 539521 tgtttatatt cattcgtaat ctcaagccac tttcgaattt tttcgaaatc catatgagat 539581 tctccttaaa tttgatttga aatcggcgca gaagggtttc cgatttggtc ttggtcacta 539641 acgtctgaat caatatttcc agtgtttaaa agtgaagacg taggcgaaag atcccctaag 539701 gaaaagtttg ctccaaaata tttgctgttc gcagtatggc tgttgtgcac agtcggaccg 539761 acatctatat ttccgttttg cgtgacgccg ttgatcttaa tatttgcgat attaatttga 539821 tatggcatag acgaaacccc tttaatctaa aattggcggt ggtgcaatcg gaggagcatt 539881 aacgttggat gtatcagagt tgccgataga tgtctggtca tttacatcag gatcgtttaa 539941 gaagttttcc attacggatt ctgtaggtga tgtatcaccg aaagaagagt tggtcccttg 540001 agatttttga ttgttggtag ggctgttata agcagcttcg cctattgtaa ttgaaccatt 540061 gcccgaaata ctgttgatct tcaaataata taggttgatt actgtagacg gcatcccatc 540121 acacccttcc atctttctgt acagtacatt atgcgccgct gcacccaatt gttccttgca 540181 tttacgggca aaactctatc tggccccgga gtgatgctca attatcagtg aatgaaaagc 540241 cattgatata ggaatcaatg aattgattca gttattcgaa atgcatgaga ccttttaata 540301 aaggaagctg gcaaacagga tcagtttgaa ataattgaca atgaagctaa tgccatgaaa 540361 taatactcgt gagtaacatt actcgtgggt attatttttg gggtggtcct agttgaaaag 540421 taaaggagta gaaagccgaa aacgattact taaagctgcc gctaatgaat tttcggttcg 540481 gggattccat gacgcgaagg taagtgaaat tgtgaaaaaa gctgggttca cgcagccttc 540541 attttacctg tactttcaaa gcaaagaagc catctttgcc gagttaataa ccgattttca 540601 ctctcgagtc agaaagctga cagagtcact tcttctggaa aacggattaa acacggagga 540661 tgtgtcaaaa cgggtactgc tagctgtaga gactgttttt caatttttgg atgaggacaa 540721 ggatttaacc aagatcggct tttttctcaa cccggaagca aaacaaatga aaaaagactt 540781 ggcgatggtt ttgaaagaga acttagaagc agaacagcgg cttggctatt ttcactctga 540841 actggatatg gaaactgtcg ctgagtgttt ggtcggcatg attgaacatt taaccgaatc 540901 atttttgtta accggaatca aagatccggc aagcctcgca gcagaggttg tgaatctttt 540961 aatttacggg atgcttccga aagggaatga tgtaagatga tatctattat gatgaaagtc 541021 agtttggcag tttttatgct tgcgggaggc atcataaagg taagccgcgt tccctttcaa 541081 gttgagcatt ggcggcatta tcaatatcca ttatggtttc tgactgttac tggcattctt 541141 gaaatagccg gggcacttgc tatgacagcg ggaatttgga atcggtatgc agcaattgga 541201 gcaggtgttc tgtttgtcgt tctcatggcg ggagcaattc atgcgcatat gtttcgagca 541261 agacaatctg tcatcatggc gatacaagcg atgatttgtt tgattgtttc aatcatgatc 541321 atcatgggga gttacacgta agcttttcac taatgtttaa gaacaagccc atttgcagga 541381 aatctccttt tcttatcgaa taatagaaag tccaggaatt aactgaatca gtaaaataga 541441 gctccatttc tgtgttattc gtccggcatc agctgggctt tttttataaa ggaggaatac 541501 aggatggcat tcactttgga agacatgact gaggaagagt tcgaagcctt tcgcgggatg 541561 tccgtgcaaa attttgcgaa acaaaacata acgtcaggaa cttggacgga aaaagaggca 541621 tttgagaaat cggagcaggc atatgagaac atgattccga atgggcgaga cagcagcaat 541681 cattattttt ggaacatcac aaatgaccaa ggagaaagaa tgggctggct ctggctgtat 541741 gctgatccat tacatccgca aaaggaagcg tttatctatt cctttggatt gtatgaagcc 541801 tttcgcggaa aaggacttgc tcaattggcg cttcaaacgc ttgatgaaag agcaagagag 541861 cttggtgcgg aaaggctggc tctacatgta tttgcacaca acgagacagc cgtctatctt 541921 tatcagaaga tgggctatgc catgaccaat atacgtatgc ggaaacagct atgctgaaaa 541981 gccgcttacg ttacccaaat acaacatgcc tatctggaag cggtggcagg gtactataag 542041 tcatcattag aaagattaag gtcatgggag gcttgaacat ataaagaaaa aggacaacag 542101 ctgttgtcct tttcaatgcc gcttgaactt tctccctcag tcttttttgt cttgatgatc 542161 cagctctttt attcgtttcg taagctcatt gaaagcctga tcaagctcct tatacccttt 542221 atcatttggc gtcataaaac tgagctttcc cagcacttct tgtctttctg tctcaagctt 542281 taaccgaagc tcctcccgct catttctttc tgaaggaacg tcgtttaact gcttttcgat 542341 gccgttgttt gagatgacga gtttactgtt tgttgttttt tcgagaaagt atcggtcatg 542401 tgaaaccgcc agcaatgtgc cgctgtattg tgacagtgtt tcttccagct gttcgcgtga 542461 cggcaggtcg agatggtttg tcggctcatc taaaatcagc acgtcttttt cctccagaat 542521 atatgccatc agcttgatct ttacacgctc acccatactc atatgcttga tcggttcagt 542581 ccattgggcg gctgtaaaac ctaagtgcct catcagattt tgaacgtgcc cccttgcttt 542641 gaatgtttca ttctcaaata actcttccgg tgtttgttct aaaggcaaat caaacacctc 542701 ctgcgttaaa tagccgatgt ttgcggacgg cgacacccat acacttcctt ctgctgtttc 542761 ctgtcccaga atgatgttca gtaatgtcgt ttttccgctg ccattggggc ctatgatcgc 542821 aaccttttcg ccgtgctgaa ttgtaaagtt tgcgttttta aagagagtcc tttctccaaa 542881 cgcttttgtt acattctgaa cttctaaaaa acgttttcct gttttgtggg ttgtatcgat 542941 tgaaaagcgg actgtatatt ctggggtaac gggttccgcc tttgcttttt caagctcttt 543001 ttcaagccgc ttctgcttgg attttatctg ggcatccgta cgcttcgctt ttacccggtg 543061 atattcttta aacccttcct ttttcgtcga ttgagcatgg gctttttccg accaagaagc 543121 gagcccattc atttgtgctt caatccgttc aaccattttt tgctgctttt catattcacg 543181 ctgctgggtg agtcttttct tctcccggaa cttcatatac ccggagtaat tccctttgaa 543241 ttcaatcagc gtctgatcct caagcgacca tatttttgtt gcggcttcgt ctaaaaaata 543301 tcgatcgtga gaaacgagaa tcacagtgcc gttataatgt ttcagctgtt ggatgagaaa 543361 ttgcaagctt ttttcatcaa ggtggtttgt cggttcatct aacagcagca gatctgcatc 543421 ctctgatagt cctttcgcca gccgcgcttt cagtttttca ccgccgctta actgatgaaa 543481 atcacgaaga ggcacatgcc atttctccag taacttcttt tcggcaggtg tctgatccgc 543541 aaaggaatac gccgcggttt cctgttcaac caaagccagt tttatatcct tccgaaggat 543601 ttgaccctgt gcaggggcta agtcattgtg aatgaggtgc agcaacgtag atttcccagc 543661 gccgtttttg ccgataatcc caatgatatc tccttgctga acactggcgt ttacatgttt 543721 aaaaacagtt tgatccttta cttcatagct aacgtttgtt aatgttacga tctctttcat 543781 ccatatccct cgctttaaag ggagaataaa aaaatcctcc caaatgtgtt ggaaggatta 543841 gccgtgcctg tgcatgatca aataagctat tttttataaa tagcagtgtc gtatatatag 543901 aaaatgggca gactaatcct attttttgat ttgaaatatt gatttcaaac ggtaaaaata 543961 agattagtta atcattgtcc acccatcatc ccttcttgtt ttgattacaa acactatagc 544021 atacctttaa attcaaaagc aaaggtcatt ttcatcaaaa aaactcctgc tctcattttt 544081 gaggcaggag ttttgagtct tattgatgct tcgcttttct cactttataa atcacaatca 544141 gcaaaataaa ccaaaccggt gtgacaaata aggaaacacg agtatcctgt gccagtgcca 544201 gcacaaccag aacaaacgcc aggaacgcaa gaatcaggta atttgtaaac ggataaagcg 544261 gaagcttaaa cttgtttgtt ttcgctaatt caggtcttgt tttgcggtat ttcatatggc 544321 agatgaccgt aatcccccaa atgtagataa agcatacggt tgaaatactt gtgatcaggg 544381 tgaatacgcc ttctggcatg atgtagttta acgtaacacc gattaaaatc acgatagctg 544441 aaaagaataa agcatttcta ggcactttac gctgagtcag tttcgccatt gactcaggcg 544501 cattgtgatc tttcgccagg gaatagacca tacggcttgt actgaataca gcgctgttgc 544561 atgctgaagc agcggatgtc aacacaacaa agttgataat acttgcagcc ccgacgatgc 544621 caacagcgac aaatacttgt acgaatgggc tttcgctggg attgatgata tcccaaggat 544681 agatgctcat aatcacgaga agagccccga tataaaaaag cagcacacgg acaggaatat 544741 tgttgatcgc cttagggatt actttttcag ggttttctgt ttcaccggcc gtaagcccga 544801 caagctcaat gccgacaaaa gcaaacacaa ccatctggaa cgagaggata aacccgtgca 544861 tgccattcgg gaacaggcct ccgtggctcc agaggtttgt gaagctggac actcctgagc 544921 ttgtggaaaa gcctttgaaa atcatcacaa ggccaatgac gattaacgcc aaaatggcaa 544981 tgactttaat caaagcgaac caaaattcta attctccaaa aagcttgact gtcgccagat 545041 tcataatcag taaaataata agagcgatta agccaggcac ccattgcggc acacccggga 545101 gccaatattg agtgtagagc ccgactgctg tcagatcagc catcgcaatg gaaatccagc 545161 agaaccaata tgtccagccg gtgataaaag ctgccatatc gcctaggtag tcttgtacaa 545221 aatccacaaa agagtgatag ttcaagtttg ataacagcag ttcacccagc gatctcataa 545281 ttaaaaagca aatgatccct gtgatcatat aagcaaataa aatcgaaggt ccggcaaaat 545341 gaatcgattt gcccgagccg agaaataagc ctgtcccaat ggctccgccg atggcgatga 545401 gctggatatg cctgtttttc aagcctctct gcaacgtttg ctgatttata ttgtctttcg 545461 tcatgtcgtc tgtcacttta tgtgttcctc cattgaaaat tgtttattga gtcagcaatc 545521 tatttttaat gattattata acactaaaat ttctatcttt tttactaaaa aaggattgat 545581 gaaaagaatt ttaatgtgat ttggactatt tcccgaaaaa agcggctcca tttagggagc 545641 cgctttttta tgctttttca gtttttgtca taaacaggta gagcccgtaa tctgtcggtg 545701 cggatgcgta gcctgcctgc cgcagcattg ctgtgatatt gccgcggtgg tatgtcccgt 545761 gattgacaac gtggggaagc agttcggaaa cagttgtttt catgattccg cttgagggat 545821 tttgaatctg gagtggctta ttgagctgtt ctttttgctg taaaaatagt atatagcgct 545881 cggataacct cagaaaaagg tcttccattt cctctatttc tttagcctct gtctgttctt 545941 taagctgttc agctaaagcc aacgcatcgc tcaaggtttt gccggaaaac acttcaatcc 546001 agccgagatc agaaagataa acatgagaca atacatggga tattgacgga aacacgcttt 546061 gaatttcttg atggtatatc tcttttggaa gctcttttaa tcggttgaat atttgttgat 546121 tggcccagac gttatattca tacaatttga atgcaaaatc tgacatgtta aaattccccc 546181 tttcgtgtgt atagctttca ttatacacga acatgagttc ttatgtagag tgctcgaaaa 546241 taaaatttgt tgacatatat agtttagagg aataaactaa ttgacattga acataaagtt 546301 tagcggggta aactataatg cgtctgatta gagctcattt cataaattct tgttttttgc 546361 agcacacctg tcgactcaag aagcaggtta tccagcaggt cagtaattaa gtttccgtgg 546421 ttatacaccc acgacccgtt ccacggattg ccccctgcat caacaggaag ggaactttgc 546481 gctccaataa tataatgatg aggattagca tgtttaaccg cttcatcaag tggcgcttga 546541 tctgtacctt gactgccgac accttcaccg cctgattcat ctaataaagc attgattgtg 546601 ttttgaacca gttcaacgtg ggcaatctcc tctaaaaaaa tgccgcgaag cagatcgcgg 546661 tactgtttct gctttcctct gaaattagag ctttggaaaa aaactgcatc attgtacgca 546721 tttctccgta atgaccgcct aatatctcct gcaggacctt agcagctgcc gggtctggct 546781 tgtccggttt aatgatatta atcagttcct ctttgtagta atacataaca cgcctcattt 546841 cttcttaaga gattttctta tattatttgt aagatgagat aaaatatata catgataagc 546901 atgggaaggc gtgaaagaag aaaataaaaa aatacaggaa aagtgttgac caaataaaac 546961 aggcatggta tattattaaa cgtcgctgat gaacagcgtg aaacaaaaca gaaaaacaaa 547021 aaagttttcc taaggtgttt acaagatttt aaaaatgtgt ataataagaa aagtcgaatt 547081 gaaaaagatt cgaaaaaaca ttaaaaaact tcttgacttc aacatcaaat gatagtatga 547141 tagttaagtc gctcaataag cgcccgtagc tcaattggat agagcgtttg actacggatc 547201 aaaaggttag gggttcgact cctctcgggc gcgccatata agataccacg cgggtgtagt 547261 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 547321 ccattattga atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt 547381 tgaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga tgcaggtcac 547441 acaggtgtca ccgcgggatg cggtggactt aacctgtgat ccatttatcg gagagtttga 547501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cgaacagatg 547561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 547621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 547681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 547741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 547801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 547861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 547921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 547981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 548041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 548101 gcccccggct caaccgggga gggtcattgg aaactgggaa acttgagtgc agaagaggag 548161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 548221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 548281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 548341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 548401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 548461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 548521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 548581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 548641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 548701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 548761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 548821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 548881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 548941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 549001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 549061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 549121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag taatacaaga 549181 tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg gatgccttgg 549241 cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc tgtaagcaag 549301 ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt ggtatccata 549361 tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta agtacccgga 549421 ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat tagcccaaac 549481 caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa ggaacgaggt 549541 agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt caaaacttcg 549601 ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg gaatccggga 549661 ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt accgtgaggg 549721 aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg tgcctacaag 549781 tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg gcgagttacg 549841 atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc tgaatagggc 549901 gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca gggtgaagtt 549961 caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg gatgaggtgt 550021 gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga aatagcttta 550081 gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag gggcccctac 550141 cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg agtcagactg 550201 cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta aggtcccaaa 550261 gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt tggcttagaa 550321 gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg cgccgaaaat 550381 gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt ggtaggagag 550441 cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga agtgagaatg 550501 ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta aggtttcctg 550561 aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa ggcgtaggcg 550621 atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat ggggggacgc 550681 aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg ctgggaaata 550741 ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag tagcgaagtt 550801 cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg taccgcaaac 550861 cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg ttaaggaact 550921 cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc aagcccgaga 550981 gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg 551041 taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag gagcgcttag 551101 cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat aacggtccta 551161 aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca acgatctggg 551221 cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca ggttacccgc 551281 gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg ttggtacagc 551341 ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg aggcatcggt 551401 gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg cggggagaca 551461 gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa 551521 aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag ggagcttgac 551581 tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg tggttccgca 551641 tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct tatctccccc 551701 aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc atcctggggc 551761 tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga gctgggttca 551821 gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt gagaggagct 551881 gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg ttctgccaag 551941 ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta agcatgaagc 552001 ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa gatgatcagg 552061 ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact aatcgatcga 552121 ggacttaacc atatttttga atgatgtcac acctgttatc tagttttgag agaacactct 552181 caatttgttt ggtggcgata gcgaagaggt cacacccgtt cccataccga acacggaagt 552241 taagctcttc agcgccgatg gtagtcgggg gtttccccct gtgagagtag gacgccgcca 552301 agcattactt ttatcatcgc ggggtggagc agttcggtag ctcgtcgggc tcataacccg 552361 aaggtcgcag gttcaaatcc tgcccccgca accaaatata tggttaaata aggagtgccc 552421 taagggtgca accaaaataa tcctatacaa atatggtccg gtagttcagt tggttagaat 552481 gcctgcctgt cacgcaggag gtcgcgggtt cgagtcccgt ccggaccgcc attaatgtaa 552541 acgaaacgat catgttttcg ttttttttgt gttttctttt actgtatctt ctgcttggtg 552601 tcatagccaa gctttcttta tatcgggaac atcttggata ttccagcaaa attcgataaa 552661 ctaggaagag cacaaatagg cataagcagg gttgaaagga ggttttggtt catggatgaa 552721 tttgatttga tacatagcat tactccgcgg accattcacc attcttccgt tgatgtagga 552781 ataggtgatg atgcagcgct ctacactgcg aaacacggcg ttcaggaaat tgtttgtgtt 552841 gatactatgg tagaagacgt gcacttcaaa ttacactatt cctcacctga agatatcggg 552901 tacaaggcgt tagccgttaa tataagtgat attgccgcga tgggaggcat tcctaagttt 552961 tatctggtat cacttgcggt accttcaaaa tggactgaat ctgaaatcaa ggcgatgtat 553021 gaaggaatga atgaactggc gaaactatat catatggatc tgattggcgg cgatacagtt 553081 tctaccgctg acaaattagt cgttacagtc actgtaatcg gtgaaattga aaagggacag 553141 gcctgtttgc gcagcttggc aaaaccgaat gatattgtgt ttgtaaccgg tgaaatcggt 553201 tcttctgcag cagggctttc tttattgctg gaagagacta atcctcaaaa ctcatctgtg 553261 gaaacggatt actttatcca caggcataaa cggcctgagc caagagtaag cgtcggcaga 553321 ttatgctcga tttttaaacg ggcagcttta aatgatgtta gtgacggatt ggctagtgaa 553381 ctgaacgaga ttgcagaagc cagctgtgtt tcaattgaaa ttgttgaaag catgcttcca 553441 attcattctg atttgcctaa gcttcatcct aactggaaag aatgggcttt gtttggcggt 553501 gaggattttg agctgacagg gacggtttca aatgaggagt gggaagtgtt gaagcaggag 553561 tgcgcagcgc ttcatcttcc cattacaaag attggctatg tcagggaaaa aacaaaatct 553621 aaagtgatcc taaaaacaga tcaaacatca atgatcttag agaaaaaggg atataatcat 553681 tttaaataag acgggtgact cgtgtgaagc aattaaaatg gagaactgta aatccagaag 553741 aaacaaaagc aattgccaag ctgacggcag cgtttgctaa accgggagac gtcctgacat 553801 tagagggcga tttaggtgca ggaaaaacga cttttacgaa aggttttgca gaagggctgg 553861 gaattacacg tattgtaaac agtccgactt ttacaattat aaaagaatat aacgatggcg 553921 tacttcctct ttatcacatg gatgtgtata gaatggaaga tgaaagtgaa gatttgggac 553981 ttgatgaata ttttcacgga caaggtgtct gtctcgttga atgggctcat ttaattgaag 554041 aacagctgcc acaggagcga ctgcaaattg tcatcaaaag agctggtgat gatgagcggg 554101 aaattacctt tactgctgtc gggaatcggt atgaaatgct ttgtgaggag ttaagtagac 554161 atgacaatat tagcaattga tacatcaaat tatacattgg gcattgcgct gcttcgagaa 554221 gacactgtta tagcagaata cattacatat ttgaaaaaga accactctgt aagagcgatg 554281 cctgctgttc attcattgct gaatgattgt gatatggcac cgcaggacct ttctaaaatt 554341 gtcgttgcaa aaggccctgg ttcatacaca ggagtaagaa taggtgtgac gttggccaaa 554401 acacttgcct ggtctttaga cattccaata agtgctgtat caagtcttga gacgcttgcg 554461 gcaaatggcc ggcattttga cggtctgatc agcccaatct ttgatgctag acggggacag 554521 gtgtacacag gtctgtatca atataaaaat gggcttttag agcaagttgt tccagatcaa 554581 aatgtgatgc tggcagattg gctggagatg ctaaaagaaa aggaccgccc tgttttgttt 554641 ttaggccatg atacttctct tcacaagcag atgatcgagg atgtgcttgg aacaaaagga 554701 ttcattggaa ctgccgccca gcataacccg cgcccttcag aattggcttt tctcgggaag 554761 gaaaaggaag cagctgatgt tcatgggctt gtcccggatt acttgcggct ggcagaagct 554821 gaagcgaaat ggattgaaag tcaaaagtag ggtgatagga tgaaaacaaa agcagcggtc 554881 agaaatatgc ggcttgaaga tatagatcac gtatacgaaa tcgaagcatc ctcctttacg 554941 tctccttgga cgaaggattc gttttatcat gagctgctgg aaaatccgta tgctcattat 555001 ctcgtgattg aaaaggacgg ccatcttgct gggtattgcg ggatttggat tgtgatggac 555061 gatgcccaga ttacaaatat agcgataaaa ccagagtatc gcggccagtc tttaggagaa 555121 acgctttttc gctcagctgt tgaactgtgc aaagaaaaag acgcaaggcg gctttcgctt 555181 gaagtgaggg tttcgaatca tcctgctcaa ggcttatata agaaattcgg gatgcagccc 555241 ggcggaataa gaaagaacta ttatactgat aacggggaag atgcgttaat tatgtgggtg 555301 acgataaatg agtgagcaaa aagacatgta cgtattagga attgaaacaa gctgtgatga 555361 gactgctgca gctattgtga aaaacgggaa agagatcatt tcaaacgtag tagcctctca 555421 aattgaaagc cataagcgct tcggaggcgt tgttccggaa attgcttcaa gacatcatgt 555481 tgaacaaatc actttggtta tagaagaggc gtttcgcaaa gctggcatga cgtatagtga 555541 tattgatgcg attgcagtaa cagaaggtcc gggactggtg ggagcgcttc ttatcggagt 555601 gaatgccgct aaagcattga gctttgcata taacattccg ttagtaggcg ttcatcatat 555661 agccggtcat atatacgcga accgtcttgt agaagacatc gtgttcccgg cactggcatt 555721 ggtcgtttca ggaggccata cagaactggt ttatatgaag gaacatggat catttgaagt 555781 cattggggaa acccttgatg atgcggcagg agaagcctac gacaaagtgg cgcggacgat 555841 gggattgcca tatccgggtg gaccgcaaat tgacaagcta gctgaaaaag ggaatgacaa 555901 tattccgctt cctcgcgcat ggcttgaaga aggctcttac aacttcagct ttagcggatt 555961 gaagtctgcg gtgatcaata cgcttcataa tgcatcccaa aaagggcaag agattgctcc 556021 ggaagatttg tctgccagtt tccaaaatag tgtgatcgat gtcttggtaa ccaaaacggc 556081 gcgcgcggca aaggaatatg atgtcaaaca ggtcctttta gccggaggag tagctgcaaa 556141 cagaggcctc agagctgcat tagaaaagga atttgcccag catgaaggga ttacgcttgt 556201 cattcctcca ttagctttat gcacggataa tgctgcgatg attgctgctg ctggtacaat 556261 tgcttttgaa aaaggaattc gcggtgcata tgatatgaat ggccagcccg gccttgaatt 556321 gacttcttat caaagtctca cgagataata gcgtgagact ttttatctgt ttgttattaa 556381 cagacaattc acaatttatc cacatatctg tgagtaatta tagagatatt gatggataaa 556441 gggctgaggt cactgttaat aaagtggata aattcagaat attttgtgga tagtgtgtat 556501 aaagcgctta ctttgtttat ttattagggg atgttctgtg gataaaaagc acctctaaaa 556561 agaggtgctt gactttttta atcttcttct gtggatagtt cttcccattc ggacaaaaga 556621 gattccagct cctgattaag cttctcattg tctgcatgga tagcttgtac tttttcatga 556681 tcctgataga cttcagggtc acatagcaat tcatcattgc ggctgatgtt ctcctcaatg 556741 gtttgaacgg tggtttcaat ttcttcaatc cgacggagtc gttggcgctc tttctttttc 556801 cattcttttt cttcctcgta ggaacgtttg gagtcagact tcactgtagc tggcgtttta 556861 tcagtttcct cttgctgatt cattttctcc aattcaagct gctctgtttt tttctctgta 556921 taataatcgt aatctcccag atactcctct atatggcttg aagaaagctc caatactctt 556981 gtggcgattc tgttaataaa atatctgtca tgtgagacaa ataacagtgt gcctggataa 557041 tcaatcagcg cgttttcgag aacttctttg ctgtctaaat ccagatggtt cgtcggttca 557101 tcaaggatga gaaagttggc tttttgaagc atcagcttag ctagagccaa tcttgctttt 557161 tcgcctccgc tcagtgaatg aactggtttc agcacatcat ctccggagaa taagaaattt 557221 ccgagacacg ttctgatttc tttttctggg agcccggggt actcgtccca cagctcatca 557281 aggacacgtt tagaggaagt caactcagcc tgttcctggt cataatagcc gacactgaca 557341 tttgagccgt aagaaattgt tccctgatct ggttttaggg tgtctattaa tgttttcagc 557401 aatgtcgatt tacctattcc gttagggccg acaagcgcag cgctttctcc tcttgtgagc 557461 atgaatgaca cttctgttaa aagcggcggc tggttttcat agctgattgt gagatcctga 557521 acacgaagga cttcatttcc gctctgtttt gtaatatcaa aatgaaagtt tgcggatttt 557581 tcatcgccaa gcggttttga catgacatcc attcgctcaa gctgctttct gcggctttgc 557641 gcccttttgg tggtagaggc tctcgccaga tttcgatcta cgaagtcctg cagctttgca 557701 atctcgtcct gctgcttttc atacattttc agatcttttt catactgcgc ggctttttgg 557761 tcgagataag cgctgtagtt gccgtgatac tttttgcttt ctgctcttga tacctcgtat 557821 acctggttta ctactttgtc caaaaagtag cggtcatgcg aaacgatgag aatggcgcct 557881 gaatagcctt gtaaataatg ctcaagccag gtaagcgtat caatatccag atggtttgtc 557941 ggctcatcaa gaatgagcaa atcaggctgt gttaatagaa gcttacctaa agccagtctt 558001 gttttctggc ctccgctgag gctttgaacc tgtgtagaat cgtcaaaatg gctgaagccg 558061 agaccatgca gcacagatct aacatccgct tcatattgat aaccgccttt atctttgaat 558121 tcctgctgaa gacggtcgta ggttttcatg atgctttcta attcacccgg gtcagctgcc 558181 gccatttttt cttccatagc ccgcatttcc ttttccattg cttttaagtg gtcaaaaaca 558241 gtcagcagct cttcttttat ggtaagctta gaatccaagc cagtatgctg ggcgagatat 558301 cccattgtaa tatctttcgg tttaataatt tcgccctttt catacgaaag ctggcctgcg 558361 ataattttaa ggagcgtgga ttttccggcg ccatttcttc ctacaatggc gatgcgatca 558421 cgatttctga cttccagctt tatattgttt aaaatagtat cagcaccaaa tgatttggac 558481 agctgattaa cttgtaagat catcatatta tttcacctct gctataataa gttaagtgta 558541 gcttatgaac cagaagtcag caaacaatac attggccata taagacatag agaagaaaat 558601 agtgtatgat ctgtttaagg agcgttttaa tatgaatgga ttttctcatt ttaatgaaca 558661 gggcagagcc cagatggtgg atattagcga aaaatcttcg actgtccgta ctgcggcggc 558721 tgtttcaagc gtacacatga agaatgaagt gtacgagaaa atacaaagtc acgatatcgg 558781 caaaggagat gtactggctg tcgcacaggt ggcaggcatt atggccgcaa agcaaacgtc 558841 gaatatcatt ccgatgtgcc atccgctttc attgagcggg gtagatatat cgtttgactg 558901 gaaaataaaa gaagcagaag ttatacttca tataaaagca caggtcaaaa cgaaagggag 558961 tacaggtgtg gaaatggaag cgctcacttc tgcatcggtg tgcgctctta ccgtttacga 559021 tatgtgcaag gcccttgata agggaatggt catcggccct actttcttgc tggagaagac 559081 aggcgggaaa aacggtgact ttaaaagaga actatccgag tataatttgg aggaccaaaa 559141 atgaataagg atcaatcaaa aattccgcag gcgacggcga aacggctgcc gctttactat 559201 cgctttttaa agaatctgca tgcgtcagga aaacagcgtg tatcatccgc tgaactcagt 559261 gatgccgtaa aggttgattc tgccacgatt cggagggatt tttcctattt tggagctctt 559321 ggcaaaaaag gatacggata taatgtggat tatttgctgt cttttttccg gaaaacgctt 559381 gatcaggatg agatgacaga cgtcatcttg attggtgtcg ggaacttggg aacggcattt 559441 cttcactata atttcacaaa aaacaataac acaaaaattt ctatggcttt tgatataaat 559501 gagagtaaaa taggaactga ggtaggcggc gtgcccgtct ataaccttga tgaccttgaa 559561 caacacgtaa aagatgaatc agttgccatt cttacagtgc cagcagttgc cgctcaatcc 559621 attacagaca gattggtcgc attaggaatc aagggaatcc ttaattttac gccggcccgt 559681 ttgaatgtgc cggaacacat tcgaattcat catatagatt tagcagttga gcttcagtca 559741 ctggtttatt ttttgaagca ttattcagtt ttagaggaaa tcgaatagag ggaaaggagg 559801 agcccaaata tgccgatcgg tcctggaagc cttgctgtta tcgcaatcgt tgctctgatt 559861 atcttcggtc ccaaaaagct gcctgaattg gggaaagcag cgggagacac acttcgtgaa 559921 tttaaaaacg ctactaaagg attaacgagt gatgaagagg aaaaaaagaa agaagatcag 559981 taagttagga tgacacgaat gaaagtgaat caaatgtcgc tgctggagca tattgctgag 560041 cttcgaaaac ggttgctgat tgtagcgctg gcgtttgtcg ttttctttat tgctggattt 560101 tttttagcaa agccgattat tgtgtatctg caagaaacag atgaagcgaa gcagcttacg 560161 cttaacgcgt ttaacctgac agacccgctt tatgtgttta tgcaatttgc gtttatcatc 560221 ggcatagtct tgacctcgcc ggttattctt tatcagcttt gggcttttgt gagcccgggc 560281 ctctatgaga aagagcgcaa agtaacgctc agctacattc cggtctctat tttgctgttt 560341 ttagcgggct tatctttttc atattatatt ttatttcctt ttgttgttga ttttatgaag 560401 cggatttctc aggacttgaa tgtcaatcag gtgatcggaa ttaatgaata ttttcatttt 560461 cttctgcagc tgacgattcc gtttggactg ctgttccaaa tgccggtcat cctcatgttt 560521 ttgacaaggc tcggaattgt gacaccgatg ttcttggcga aaatcagaaa gtatgcgtat 560581 tttacgctgc tggtgatcgc agccctgatt acaccgcctg agcttctgtc ccatatgatg 560641 gtcacagtcc cgcttttgat tttatatgaa atcagtatcc ttatatcgaa ggccgcttat 560701 cggaaagcac agaaaagcag tgctgccgat cgggacgtgt cttctgggca ataataaaaa 560761 atccatttct catgcgagaa atggattttc tttatttttg gttctttttg attttaaatg 560821 aaaaggcgaa catcttaaaa gaaatgctga tgttgtaagc ggcgaacacc atcagcagga 560881 tggagtaaaa tgaccacatg ctgcctggcg agcttgcggc aagataagta aagatgcacc 560941 ctacggcaaa gtagatcatt ccccaaacta ccgggtttct cataaaaata atcctccaat 561001 aatcaattgc atttgtgtgc tctgctgttc aaggtaatta cgaacaggct caagctgcat 561061 gatgacgacg aatgtattca tcattaaatg ggcgaaaatc ggcacccata tccgttttgt 561121 tctcgcatat aaaaaggcaa aggtaaagcc cattgctgta tatagaagga gatgcttcaa 561181 atcagcgtga acaataccga agataaccga gctgatcagt cctgcgaaaa agaaattcgt 561241 tttttcgtac agcgcgccga aaatgatttt tctgaagatg atttcttcta atataggccc 561301 gacgatggaa gaaacgataa tcatgagcgg gactgcctga atgacatcca gaatcgcttg 561361 tgtattttct gattctcttc cgatgccaaa aacataatat tcaatagagc ctgctattcc 561421 ttgagagaaa agggcaatga aaaaaccggc tatcgcccaa aggatagaaa gtccgattga 561481 gtccttctgt ccgtttcgca gcgtttcttt cggaacggtt ctcagaatga gcagaacaac 561541 aacgagacag gcgataaagc tgataacgga ccataatcct tgtgcatgca gcatattttc 561601 atctgtaggc tgtcctccgg cataaccgaa tttaaataac aagggaatcg cgattaatgc 561661 ggaaaactgc atgatgatat atgtcaaaat aataaaccaa tactgttttc tcaaatggta 561721 tgtactcctt tgttaagtgg gtttcgttca tctacagcta ttgtaacata atcggtacgg 561781 gggtgaaaaa gctaacggaa aagggagcgg aaaagaatga tgtaagcgtg aaaaattttt 561841 tatcttatca cttgaaattg gaagggagat tctttattat aagaattgtg ttagcactct 561901 ttagtgctga gtgctaaaat tacatattca tactattgag gaggttattt cattgttaaa 561961 gccattaggt gatcgcgttg tcattgaact cgtagaatct gaagaaaaaa ctgccagcgg 562021 aattgtgttg ccggattctg caaaagaaaa accgcaagaa ggcaaaatcg tggcagctgg 562081 ttcaggtcgc gtgttagaaa gcggagagcg cgttgcttta gaagtaaaag agggcgaccg 562141 cattatcttc tcaaaatacg caggtactga agtgaaatac gaaggtactg aatacttaat 562201 cttacgtgaa agcgacattt tagctgttat cggctaattc ttaaataaac aatacttaaa 562261 acatttgagg aggtcttgta aacatggcaa aagaaattaa gtttagtgaa gaagctcgcc 562321 gcgcaatgct tcgcggtgtc gatgcacttg ctgatgctgt taaagtaact ttaggaccaa 562381 aaggacgcaa cgtggttcta gagaaaaaat tcggttctcc gttaatcaca aatgacggtg 562441 taacaatcgc taaagaaatc gagctagaag acgcgtttga aaacatgggt gctaagcttg 562501 ttgctgaagt agccagcaaa acaaacgacg ttgccggtga cggtacaaca actgcaacag 562561 ttcttgcgca agcaatgatc cgtgaaggcc ttaaaaacgt aacagcaggc gctaaccctg 562621 taggcgtgcg taaagggatg gaacaagctg tagcggttgc gatcgaaaac ttaaaagaaa 562681 tttctaagcc aatcgaaggc aaagagtcta tcgctcaggt tgctgcgatc tctgctgctg 562741 atgaggaagt cggaagcctt atcgctgaag caatggagcg cgtaggaaac gacggcgtta 562801 tcacaatcga agagtctaaa ggcttcacaa ctgagcttga agttgttgaa ggtatgcaat 562861 tcgaccgcgg atatgcgtct ccttacatgg taactgactc tgataagatg gaagcggttc 562921 ttgacaatcc ttacatctta atcacagaca aaaaaatcac aaacattcaa gaaatccttc 562981 ctgtgcttga gcaggttgtt cagcaaggca aaccattgct tctgatcgct gaggatgttg 563041 aaggcgaagc acttgctaca cttgttgtga acaaacttcg cggcacattc aacgcagtgg 563101 ctgttaaagc tcctggtttc ggtgatcgcc gtaaagcaat gcttgaagac atcgctgtcc 563161 ttactggcgg agaagtcatc acagaagatc ttggccttga cctgaaatct actcaaatcg 563221 ctcaattggg acgcgcttct aaagttgtcg ttactaaaga aaacacaaca atcgttgaag 563281 gcgctggcga aacagacaaa atttctgccc gtgtgactca aatccgcgct caagtggaag 563341 aaacaacttc tgaattcgac agagaaaaat tacaagagcg tcttgctaaa cttgctggcg 563401 gcgtagctgt catcaaagtc ggcgctgcga ctgaaactga gctgaaagag cgtaaacttc 563461 gcatcgaaga cgccttgaac tcaactcgcg cagctgttga agaaggcatc gtatccggtg 563521 gtggtacagc gcttgtaaac gtatataaca aagtcgctgc agttgaagct gaaggcgatg 563581 ctcaaacagg tatcaacatc gtgcttcgcg cgcttgaaga gccaatccgt caaatcgcac 563641 acaacgctgg ccttgaagga tctgtcatcg ttgagcgcct caaaaacgaa gaaatcggcg 563701 taggcttcaa cgctgcaact ggcgaatggg taaacatgat cgaaaaaggt atcgttgacc 563761 caacaaaagt tacacgctca gctcttcaaa acgctgcgtc tgtagctgca atgttcttaa 563821 caacagaagc tgttgtcgct gacaagccag aagaaaacgg tggcggcgca ggaatgcctg 563881 atatgggcgg catgggcggt atgggtggaa tgatgtaata aagggatatt aacccttata 563941 catcaatgtt ttaaccgtct taaaaaacta gacaaagcgt gaataaaaaa agagaaggtc 564001 tttcatcagt ttactaaact gttgggagac cttttctcca tattagcggt catatgagca 564061 taaatgtcca tcgtcgtatt tatgtccgaa tgaccaaatt gttgctggat ttctttaatg 564121 cctactcctg cctcaattag taaggaggta tgggtatgcc taaaagagtg gggggtgaca 564181 ttctttttat cccagctttt ttgagcagcc gtttaagtct agtctcaata acctttctta 564241 attgcggatg accatcctcc cgctcaaaaa taaatgatga gtcttgataa atcaatctat 564301 ttttaagctt aatttcattt tgataaattt tatttttttt tagtagattg acatcgtttc 564361 atcaattcga acgatatcaa cagatcctgt tgttttaggt gttagcaatt ggtatttttc 564421 aatttgattg ttaggggtgt atagggtctt tgtgacctgg cttatcattg aaatctgtcc 564481 attttaaagc aagaagttca ccaattctta ggtcggtcta ggcaagtacg gtaaagacca 564541 aatggtccat ttctagcccg tcagattgag cgagctttag aaaatgtgtc agcacctctt 564601 tttccaatgc tttgttgctt cttgggtaat tgaaaatccc cagttgggtt cattttaata 564661 atcccttgag ttttagcttt tcggaaaatc atacggccgc aggcatgaat acctcccaaa 564721 caattgtgac tgtattgctc gttcagttct aacgtgcggt cttcatacat ttttttgtgt 564781 tttgctaatc gggtattgac ccaatactgc gataaaatgc atcattttct tttcactggc 564841 ccgtacactg cttattttta ccccactccg gttgtaaatc ttaagccaac cttttgcaaa 564901 tgttttgaag ggcatatctg actccttaat aaaagtcccg ttgtcgtttt ggagttctac 564961 gtgacgggct gctactgggg cttctttctt tgttttaaat cttcctttgg atatttctag 565021 acgttttttg gttaaagggt caatgcctag tagatatgat aactccacgt cttaccgcat 565081 tgcttgagtt ttgccattta tttgtcccta actaattttt tttcatcaaa ttggtcttta 565141 agtgagttta ataatttttg tttctctcga ctggtcaata attgcccttc atatttcaaa 565201 agattggata aatttgagat ggaatcaatc ctgatggatg gtaccgtaga ctttaataag 565261 aaacgaaagg ccaactgcga cttcagttgg cctttcctat ttataataaa gaaattgagt 565321 gagattgctg acagaactac gtactactcg ttttctttag ttgcccttgc taatcgttca 565381 acctctcccc gaatcccaat cgcaggctcc cacgaatcaa tcaaacgaat cgccttctga 565441 ttagattcca ccgctttcgt tttctctcct ttacgataca acagctgcgc cattccgtag 565501 tgatagtaga tcagttcaac ttgattggcg ttatgtttgt catagagcat ttgctcaaag 565561 gcttcttccg ctttttcaaa ctgatcacat ttcacgtaag cgacacccag attgaaatag 565621 gcttctatcg ttttttcgcc gccgtatgtg gagctgattt catttgccgc ttcgtataat 565681 tgaatggctt ctacatgata acctctcgca aagcttaagt caccgcgaac caatagaact 565741 ctgtgttgaa tggtagggga aatcggttga ttttcgattt cgtttaaaat tgtctctgct 565801 ttttcctgtt gcccgtcttt taaaaacagc cttgctttga gtgcatgtcc ccaaaccttt 565861 agatcatagg catcgtgagc gtctgattgt tcaagaatct tcagcccggc ttctatttgc 565921 tgaagcgctc cgtctaaatc attgacttcc atcaatgccc agcctgaggt gtcgattcgg 565981 aagtacgctt ctcgtgtgtg ttggcctaag tgatgggcgg cgtcggccgc tttgcgtccg 566041 tattcgattc gcaggggcag gttgattctg cttagaaaat ggctaatgcg ggtgatgagt 566101 tcgattagga tttctttttg ttcagtttca cttgcccatt ggatgacctt taagatgttt 566161 ggccattctt gtttcatttg atctaagttc cgtcccagca ggtagctcca atagatagag 566221 ttgggctgtt cccgctttaa atgggtttcg gcataatcaa tataatagtg cgcccagcga 566281 ttgcgggctt ctttttcata ttcgtgctgt tcggacaagt gctgttctcc gtaagcgaca 566341 acggtttggt gcgctaagta ttgtgtcctg ccttggcttc gttccggctg aatcagcgca 566401 tatgaccgca tttgttccat agcgtaatga aaacggcggg cgtctaatcc ggctgctgcc 566461 gccaggcttt tttcatcagg cggcttgctg aaaaagcaaa gcgtctgcca gagctttcgc 566521 gtatcttcat tgcatctatc ccaggtgcgg ccaaagagga attcaaacaa ttccagcagt 566581 gagtagcctg cttttccaag ctcatgaatc agctgctgag cggggatgtc atcgtctgac 566641 atataggcaa tgctgagtgc catggctttc gggtttccgg cagtcgctga aatgaattcg 566701 tttttcaggt cagatgatag atgtaacagc tgctccagct tttcccgttt acgtgggagg 566761 ttgcatgttt gtaagcagtg atgcacttct tgttgaaaaa attcgtgggc atctgtttgg 566821 tcaagaccgc ttagctgaat ggctgtcatt tctccgaagc tttcccgata agtttgcttt 566881 acgttttccc gcgctgtaag gagaactttt acgccttgcg gaaggctggt gataaattca 566941 tgaatgtcac gttctgcagt atcaatgctg tcaacgatca gcaggatcgg tttttctcta 567001 gtgtaattgg ctaacgcatt gcggacgaca aaccgtttta cattgattga tttatcgatt 567061 tgttctttgc gtccgagctg ataggcgatc gtatttaaaa aatcgctaaa gcttaatcct 567121 ttccaatcag cgctgaccca gatgatgctg ttgaatgccg gccaaactga agtatcgtcg 567181 acacaggaat aggcggcttc aagagcaatt gtggtttttc ccatgccggc ccagccggtg 567241 attaaacaga ctggtgatgg agaaagcatc cattgccgta tcgcttccat atcaaagctg 567301 cgtccgataa agcgtccgga ccagcgtgag ggtaaattat gcgtgatggg ctgttctgta 567361 agcgcattcg tttcttggcc gggtctgtca tgaaacagcc gttttactac attttcaatt 567421 tcgccttcac tcggagcccc gaataatccg tcttttcgca gtattttcgc ttttttcaaa 567481 caggatgctg cccatacagg caatgcgggt ttgatgactg ggatagtggt ggcttccagc 567541 aagtcggtca accactcgat atccaagtcg gtcttttcga gaatgatcca gatcattccg 567601 aacagttttc cgtcgtcgat tcttccggga atgtagtttg cccccatctg tccgatccag 567661 cttttgatcg tgtttgggga gactcccagc tggagtgcga ttttatctat gtaagactgt 567721 cctgtttttt cattcttttt ccttctgact ttataatcag gatgaagttt tagcgttttg 567781 acgccaggtg ccagcatttg tgcaaattgt tttcggtttt caagttcagc cataagcctg 567841 cacctcctat tagtactatt ttatcaatcc agcgtttttt gtatatgaaa aaataaaagt 567901 acagtgccgc tgtcctttta tacagcagga aaggctgttg aacgtgttaa aaagcagata 567961 aaatgggggc agtaacagag aaaacaaaaa tgtatgcact tacattttat tttctaaaga 568021 aaggaacttg ccaaatgact cacacagtac ctcaaaacat gaaagcggct gttatgcaca 568081 acacaagaga gatcaaaatt gaaacattgc ctgtgcctga tatcaatcat gatgaagtgt 568141 tgattaaggt gatggctgtc ggaatttgcg gatctgatct gcattactat acaaatggcc 568201 gaataggcaa ctatgttgtg gaaaaaccat ttatccttgg gcatgaatgt gcgggtgaaa 568261 ttgccgctgt cggatcatct gtcgatcaat tcaaggtggg agaccgcgtc gctgtagagc 568321 cgggtgttac gtgcggacgc tgtgaggcgt gcaaagaagg acgctataat ctttgcccgg 568381 atgtacagtt tttggctaca ccgccggtag acggtgcgtt tgtccaatat attaaaatgc 568441 gtcaggactt tgttttttta atcccagact cactttctta tgaagaagct gctttgatcg 568501 agccgttttc tgtcggtatc catgcggcgg ccagaacgaa gctacagccc ggatcaacga 568561 ttgcgattat ggggatgggc cctgttgggt taatggctgt tgccgcagct aaagcatttg 568621 gggcaggcac aatcattgtc accgacttag agccgctgcg gttagaagct gcgaaaaaaa 568681 tgggagcgac tcacattatt aatatacgtg aacaggatgc acttgaagag attaaaacga 568741 tcacgaatga tagaggcgtt gatgttgctt gggaaacagc agggaatcca gcggcattgc 568801 aatccgcact ggcttctgtg cgccggggcg gaaaattggc gattgtcggt ttgccttcac 568861 agaacgagat tccgctcaac gtgccgttta ttgcggataa tgagattgat atttacggga 568921 tcttccgtta tgccaatacg tatccaaagg gaatcgaatt tcttgcttca ggcattgtgg 568981 acacgaagca tctagtaacg gaccaatatt cgctggagca gacgcaagat gcgatggagc 569041 gggcgcttca atttaagaat gaatgtttaa aagtgatggt gtatccaaat cgctgagtga 569101 acagggagga tcttcgtatt ctccctcttg tttactggaa atgaaaacgg attcttgggg 569161 tgggaaatga tgattggaac agaaaaagta acggcattga aggcgaagca tcagtcaaaa 569221 tccagcaccg gcctgtcctg gtttgaacga atcggttatg gattcggcga tatgtcgtat 569281 aatattatct ttcagtttgt aaacgcatac ttattatttt attatacaga cgtcggcggc 569341 attcagcctg cggtaatcgc aactttgttt cttgttgtgc gtgtgctgga tgctattttt 569401 gacccgatca tgggattgat tttagataaa acgaatacaa ggtggggaaa agcaaggcca 569461 tatttgctgt gggtggcatt tccttttgcg ctattcacat tcttatgttt cacgacgcct 569521 catttcggtg agaccggaaa tatggtatat gcgtatgtca cttatattct gcttgggatg 569581 tcctttagta tgcaaacgat cccggtgaac agcttaacgg ggcggatgac gaattcggtg 569641 gaggaacgaa cggttctgac cacaacccgg atgattttgg tgtatatcgg cattctttta 569701 tccatttcct gtgcgacacc gcttgcaact gctatcggag gagaggatca ggcgtttgga 569761 tttcagatga cggcgctcat ctatgcggct gtcagcatcg ttttgaatct atttagtttc 569821 tttactgtac gggagcggat tcagcctaaa aagagaaaaa aacaagggat caaaaagacg 569881 ttatccgttt tattcaaaaa caaacccttg ctcatgttaa tttcatcatt tttggctttt 569941 gcgatcgggt ttaatattaa gctcagcacg atggtgtatt attttacgta taacgtaaac 570001 cataaagagt tcgtgtttat gggcaccgtt ttatttttcg gggcagcgct gatcagcaat 570061 ttgtttattc ctttcttttc tgagaagtgg ggcagaaaac aagtcatgat tatcacggca 570121 gctctatcgc ttatttctta tgccggcctg cattttacgc cgtattcttc aattccactc 570181 attttcattt ggcttttcgc ttcgggattt ttcacaacgc ctttaaatac gcttgcttgg 570241 ggaatggttg cggattgcgt cgattatgcg gaatggaaaa ccggaattcg cgcggatggt 570301 gttgtgattt cgagcatgag ctttattaat aagctgggtg ttgcgttagc cgggtcattt 570361 tcggccattt atttaggaat cgccgggtat gtggcgaata cagaccagac agttgcgtcg 570421 ttgaatgcga ttaaaaatat gaatgctttg attccgggat ttttcatttt gctttctatt 570481 attcttatcg ccttctatcc tttaacggaa aaaagatata aacacatcat ctctgagctg 570541 gagcaaaggt ctgcgagata aatagatgta aaatttttaa tattcaatgt tgtatttatg 570601 gcaaaaagta atatactgag actgtaatct agactttata aatgagtgtg ataatatgcg 570661 tagtcattct gtagtttgta ttggggaatt gttgattgat ttcttttgta ccgatgttga 570721 cgttgattta atggaagggc gccaattcct gaaaagtgcc ggcggggcac cggcgaatgt 570781 gtcggcagcg attgccaagc tgggcggaga cgccgctttc agcggaaaag taggaaagga 570841 tccgtttggg tattttctga agcgaacatt ggacgctgta catgtcgata cctctatgct 570901 ggtgatggat gagaaagcgc ctacaacgct tgcttttgtt tcattaaaac aaaatggaga 570961 gcgtgacttt gtttttaata gaggcgcgga cgctttgttt acgctggagg acattgacca 571021 ggaaaaacta aacgaagcga aaatccttca tttcggctct gcgacggcac tgttatcgga 571081 tccgttttgc tcagcctatt tacggttgat gtcgattgcg aaagacaatg gacagtttat 571141 ttcgtttgac cctaactacc gtgaagattt atggagggga agagtctcag agtttgtaag 571201 tgttgcgaaa aaagcgatcg ctgtaagtga ttttgtgaaa gtcagtgacg aggaacttga 571261 gattatcagc ggtgtgaagg atcatgaaaa gggagttgcg atccttcatg agatcggagc 571321 caacattgtc gctgtgacac ttgggaaaag cggaacgctt ctttccaatg gaaaagaccg 571381 tgaaatcatt ccaagcattc cggtgacatc aattgactca acaggggcgg gagatgcttt 571441 tgtcggtgcg gctttatatc aattggcaaa cacggatcag attcaatctg tagatgctga 571501 ttttgtgaaa ctgcgtgaga ttgtggcgtt tgccaataag gtcggagctc ttgtgtgcac 571561 taaaattgga gcgattgatg cactgccgag tttggatgag attggagttt ctttgtaaat 571621 cattgaagat gtttcttgaa agtctttgga cttttggggg catctttttt tattgcttac 571681 atttttgttc aggtaaaaag ttgtatattt tttgtttgaa atgtcatttt ttattaaaaa 571741 agtgaaactt ttaacgataa taaatagtat atgtaacaag ggttaccgaa ttagctttag 571801 gaggaacgat ataatgagta taattggaag atttaaagat attatgtctg cgaatatcaa 571861 tgctttattg gacaaggctg aaaatccgga gaaaatggta gatcaatatt taagaaatat 571921 gaatagcgat ttggctaagg ttaaggcaga aacagcagct gttatggctg aggagcagag 571981 agcaaaaaga gaatatcacg aatgccaggc ggatatggaa aagatggaaa gctatgcaat 572041 gaaggcgctg caagccggga atgagagcga tgcgagaaaa tttcttgaaa gaaaaacatc 572101 tttggagtca aagctttctg agctgcaggc ggcgaatcaa attgctgcaa ccaatgccgc 572161 acagatgaga aagatgcatg acaaattggt atctgacatt ggagagctgg aagcacgcaa 572221 aaatatgatc aaggcgaagt gggcagtagc gaaaacgcaa gaaagaatga acaaactggg 572281 cgcttctgtt tcaagtacaa gccaatcaat gtctgcattc ggccgaatgg aggacaaagt 572341 aaataaggca cttgatcagg ccaatgcaat ggctgaactg aacagcgctc cgcaggatga 572401 tatggctgat ctgtctgcaa agtatgacac tggcggttca agccaggttg atgatgaact 572461 tgcggcgtta aaagcgaaaa tgatgctcga taagtaatac ataggaggcc gcagctttcg 572521 gctgcggcgt cattttatca taaaatgtga gagggaacgg taatgataat atcttataag 572581 tgtccgaact gcggcagtga tatggcattt gacagtgaaa ccggctcgtt atcctgcagc 572641 agctgcggaa gacaggacaa tattgaaagc cttccgaaag aaaacattgc ggcacggttt 572701 tctgatgatg aagcaaaaga atatcaatgt aaaaactgcg gtgccgtttt gatcacggaa 572761 gctgaaacga cagcaacgac gtgcagcttc tgcggaggtg ctgcaatact tgccgatcgt 572821 ttatcaggac atttggcgcc ggcgaaggtc attccattta caatcagcaa gcaagaagcg 572881 gagcaggcat ttcgaaagtg gtgcaaaaaa ggccttctga caccaagagg tttcatgtct 572941 gctgatcgta tcaaaagcat caccggcatg tatattccat tttggatgtt tgatttaaat 573001 agtgaagtac aggtgagagc aaactgtacc agagtccatc aatatgaaga aggggattat 573061 atttgcacgg aaacagagca ctttgaagcg tttcgtgata tcaatctcga ttatttgaaa 573121 atccctgtcg atgcctctga aaaaatgaaa gacgaattaa tggacaaatt ggagccttat 573181 tcatacgaag agctgaagga ctttcaaacg gcatatttgg ccggttatat tgcggaaaag 573241 tacaattata ccgatgagga gctttttccg agggcaaaag agaaaatcag cagttatata 573301 gattcataca tccattctac tttttccgga tatacgtcag tcaatgtgag ggacaaacat 573361 attcacacga aaaacgtgaa cagcttttac gttttgcttc ctgtttggat ggtcagttac 573421 gattatgaaa gagcggagca tatctttgcg atgaacgggc aaacaggaaa ggtcgttgga 573481 aagccgccga tcagtcgagg aaaagtggct gcatggttta gcggaatagc aggcgggaca 573541 tttcttgcgt tgaagctcgt ctcattgatg atgggaggcg gattttgatg cgtggatttt 573601 ttgggaaagc gatctttgtt gtgctggctg ttttcatcat gatgccttta ctgggtatcg 573661 aagcggtaag agcctctgaa ttgcagcagc atgtgtacga tcgcgctcat ctattgtcaa 573721 aagcggagat cggaaaactt gaatctctct cggcaaagct gggtgcaaag agggacactg 573781 atttcatcat tattacgacc aaaagcacaa acggtgaaga tattgcagac tataccggcg 573841 atttttatga tcgttacgga aaaggcagta cagccattct gacgattgat atgacaaaca 573901 gagaagtgtt tatcgcaggc tttaaaaaag ccgaacagta tttggacaac agcaggctca 573961 atagcatcag aaatacgatt tcatctgatt tatccaatga aaattatttt gaagcttttg 574021 agacatatat tcagctttcc tataaagata tgggcataaa accgggagta aaccctgaca 574081 acatattctt tacatggtgg tttcagctga ttgctgccat cgcagtcggg ggaattgcgg 574141 tttcaatcat gctttatcat gcaggcggca aagtaacggt taatggaagt acatatatgg 574201 atcagcgtac gtctgatgtg attgatcaat acgacactta tattagaacg actgtaacaa 574261 gagaaagaaa accatcagat aaagacagcg gcagcgatgg cggtgttacg aaaggcggca 574321 cgtcatacag tgggagccgg ggcagttttt aaatgtaaga aatagagaaa gggagaggcg 574381 taatgtcgtt tttcagaaat caattagcga atgtagtaga gtgggaagaa tttagagatg 574441 atatgatttt ttataaatgg aacaatcgtg aaatcaaaaa agggagccgt ttaatcattc 574501 gtcccggaca ggatgctgtc tttttgaaca atgggcgggt tgaaggagtc tttcaagatg 574561 atggcgatta tgatattgaa tcagaaatta ttccattcct ttcaacgtta aagggcttta 574621 agtttggctt taacagcggc atgcgagctg aggtgctgtt tgtcaatacg aaggaattta 574681 ccgtaagatg gggaacaaaa caggcgataa atattccggc agcgggaatg ccaggcggga 574741 tgcccattcg cgcaaacggc acatttaatt tcaaggtgca ggactatatc agcctgattg 574801 ataaaatcgc tggcgtgaaa gatcaatatt ttgtagagga tattaaaacc cgtatcattt 574861 ctattctgga tcagcttctc atgaagtgga tcacaagaga agggaaagat atgtttaatc 574921 ttcaagcaaa cgcttttgat attgccaagg gaattcaaga ggacttagat atgcaattaa 574981 taagcgacgg gatgacggtc actggttttc aaatcatgag ctttaattat cctcaagagg 575041 ttcaagatat gattacaaag aacgcttcct acggtatggt tggggatgtg aacagatacc 575101 agcaaatatc aatgacggat ggaatggcat ccggaaagat gagcggaagc ggagcggctt 575161 cggatatggc tggaatgatg atgggaatga atatggccaa tcagatgatg aaccaaatga 575221 atcagaatca gcaggcacag tcatcaggcc cacagtcaac tggcagcgga agcaaaccga 575281 atttctgtcc aaactgcgga acaaaaacgg gcgaagccaa tttttgtccg aattgcggcc 575341 agaagcttgt ataagaatca tacagtgaaa agtccggagt gatcagcact cgggactttt 575401 ttatttagga gaataagcat tacctattgc ttgctcctga acaggccatt ttcgagcccc 575461 cgcttggata attcccagca gcaattgacg acgttccttt attgaattga cggcaatttg 575521 aaatgtttgc tttgataaag ccggtatgcc tgattgttga agctttgaga tgtctggttc 575581 tggcggcgct tgttctgcag gatggatata ggcagtatga acggtatcca gatagttttt 575641 gatacttgag cgcgcttctt tgatatgaag ctgattcggc tgatattgtt caggaattcc 575701 gtatttgaaa atggttagag cctcatccaa tacagcaaca gctataatgg atgattcctg 575761 atgctgcgtg ctgtggtaaa aatgaaggat ggggaaggcg ttatgctgag cggtcagctt 575821 tcccagttct gatgaggcag cgacaagaag aaaatcaatg tcgtgaaaat ctttgccatt 575881 ccatgcatta tggacgattt cagttccgtc atgccctaga cttaatacac tttgggcaaa 575941 ggagcgtttt tgattaaccg cactcaagac ggaaatcaaa tacgtgacag aaaatgtgat 576001 ggtaagcagt ccttgagctg tttcaataat cgtgacaagc ttccataggc ctccgttcgg 576061 agcgaggtcg ccatttccta atgtaaacat gacatagccg gaaaaataaa ttcggtctga 576121 ccaggaagcc ggttcttttg attgagtttc cataagtgag tgagggtcac tcgagtaaat 576181 caaaacccac ccgctccaaa atagactgat ccatatcact aacgtcaggc ataacagcag 576241 aggaccagcc atacttagaa cctttgcgtg gtcaccgctg attttgcggc agcccttcca 576301 cagccaggca gacaggcatc ttgtgatcgg gccggcaccg ctctctaacc ataacgtggt 576361 ccataaaaaa tcaatcatcc ccgctgtcaa taataaaagg cctgcaatga tataaccctc 576421 attcattttg gttgcctccc ttaagtcagc cttcttttat tttcttctct atttcctttt 576481 atcctgagtc tgaaacaatt gaacgaatgt ttgattttac agagaaaaat aggtgggagt 576541 tacccaacac ttactcattt ttcaatatga acagaaaatc acaagatttt tgacttgatt 576601 cacacatttt catgaagaaa aacgttcatt ttccccttga attggtgatt ttccttttat 576661 agagtaaaaa attttcagaa atttatattg actgaaagcg tttttataat tatgataata 576721 tcagatataa caaaaatgtc actataacat cactacaatt gaactattaa gtgactaata 576781 aataccaaat gaacgaggtt atgcacaaag aaatgaccat tgttctttta acgagaaatg 576841 aaatcgcttc catagggatt gacatgctaa gaagaaggga aggttatgag gttattggat 576901 aaaaacatga acaactattt tctgaagcct gcttacgaaa tgtgaggaag gcagcagccc 576961 tggaataagt ttttgacata cgcattttga aaaagactgg gggaaacagt atgaataaac 577021 aaggaaatca aatgtcattt ttacgtacaa ttattttagt ctccactttc ggcgggcttc 577081 tttttggcta tgataccggt gtgctcaatg gagctttgcc gtatatggga gagccggatc 577141 agcttaatct caatgccttc acagaaggcc ttgtcaccag ttcacttctt tttggagcgg 577201 cactgggtgc tgtgtttggc ggcaggatgt ctgattttaa cggccgccgc aaaaatattt 577261 tgttcctcgc tgttatattt tttatttcaa cgattgggtg tacgtttgca ccaaatgtta 577321 cggtcatgat tatttcccgt tttgtgctcg gtattgcggt tgggggtgca tccgtaacgg 577381 tgcctgccta tttagcagag atgtctcctg tggaaagcag gggacggatg gtgacgcaga 577441 acgaattgat gattgtatca ggacagcttt tggcctttgt ttttaatgcg atccttggaa 577501 caacaatggg agacaactcc catgtgtgga ggtttatgct ggtcattgcg tcacttccag 577561 ccttgttcct gtttttcggc atgatcagaa tgcccgagag tccccgttgg cttgtttcta 577621 aaggaagaaa agaagatgct ttgcgtgtat tgaaaaaaat cagggacgaa aaacgggcag 577681 cagctgagct gcaagaaatt gaattcgctt tcaaaaaaga agaccagctt gaaaaagcga 577741 catttaaaga tctttcagtc ccatgggtgc gccgtattgt gtttattgga ttagggattg 577801 cgattgtaca gcaaattaca ggtgtgaatt cgattatgta ttatgggact gaaattctaa 577861 gaaattccgg tttccaaacg gaagccgctt taatcggaaa tattgcgaat ggcgtgattt 577921 cggtattggc aacattcgtc ggaatctggc tgctgggaag agtggggcgc cggccgatgc 577981 tgatgacagg cttgatcggt acgacaacag cattattgct aatcgggata ttctcacttg 578041 tacttgaagg atcaccggca cttccgtatg tagtcctgtc attaacggtc acatttcttg 578101 cttttcagca gggcgccatt tcaccagtga cttggctgat gctatctgaa attttcccgc 578161 ttcgccttcg cggactggga atgggtgtta cggtattctg tctgtggatg gtgaattttg 578221 cagtcagttt cacgtttccg atattgctgg cagctatcgg gctgtccaca acgttcttta 578281 tcttcgttgg attaggaatt tgctctgtct tgtttgtgaa gaggtttttg ccggaaacga 578341 aagggctttc gcttgagcag ctggaggaaa acttccgcgc ttatgatcac agcggggcaa 578401 agaaggattc tggggctgaa gtgattggat aatttaaaaa agaatccgca cccgagtgcg 578461 gattcttttt ggtttcaaat tagttaggtc taacaaggat tttgacttgg cttttctctt 578521 taataagagc cccgaagcct tcctcgatca aatcatctag tacgattttt ttcgttacga 578581 gtttgtcggc tgagaaatag ccttctttca ttaatgacaa tacagccggg aagatgtcgc 578641 ggtatccgat aattcctttt actgtacgtt ctttgattac gatatcgttc ggatggattt 578701 cagcaccttt ttcccaaatg ctgacgatga cggtttcacc ggcaattgta gtggactgga 578761 tggcttgtcg taacaccact gggacaccag tgacttcgaa tgctacgtca acaccgcctc 578821 ctgtacgttc tgcaatctca gcgactacat cgtctgtttt agacggatca acgatgatcg 578881 cgccaagctc ctcagctttt tgctggcgtt caggagaaag ctcaacagcg taaatatcag 578941 ttgcaccggc agccttcagc gcttcaatga caagaagtcc gatcgggccg cagccgaata 579001 cagccgcttt gtcgcctgct ttgagtttgc ttgagcggac agcgtataga gcaactgcag 579061 aaggttcaac gagcgcgcct tgttcatatg ataattcatc aggaagtttg aacaaaagct 579121 cttcatccac agagacgtat tcagagaaac cgccgcctcc gccggctaag ccgaggaatc 579181 ccatttgttc atcaaggttg taggcgcctt ggtggccgtg tgtagcaaaa atcggctcga 579241 ctacaacgcg gtctccaact ttataatttt caacgccttc tccgacttcg acaacttcac 579301 cggagaattc atgccccatt gtgacaggtg ccgtttcatt tgttaatggg tgcggtttgt 579361 caaccggaat aaagatcggg ccgcccagat attcgtgtaa atcacttccg cagatgccgc 579421 accatttgac tttgatcttt acttttcccg gctccgtttt tggctcttcg atatgttcaa 579481 tacggatatc cttttggtta tgccatcttg ctgccttcat ggattaccac tcctataact 579541 tttgatgtga gtaattccgc accggtcaat atgaactgtt cacaaaatcg ccatttttaa 579601 aaccaaaaaa gaaatgaaat ttttatataa tataatctac gtttttttga aaaaaagaaa 579661 ctttaaagaa aaaagggtct cgcacactct tttttcttta tatgagagta tcaatcgttt 579721 acatagctat gaatttggtt tgaacaatac ggtaatggtt cgttcatatt gaatgcgaca 579781 actactctat caataattat aactctaata ctgctattat aataggataa tcttccatgg 579841 tttattttag cagaggtaac ttttttgact ttgtaacatt actgtaagga tattgaaata 579901 aaaaatagct ggttgatcgt gtataatctt cctagatgtt aacaaacagg gggacgaaat 579961 gttgaagaaa gtcattttag ccgcttttat cttagtagga agtactttgg gagcttttag 580021 tttttcatca gatgccagtg cgaaacatgt gaacggaaat attacttggt ataatggagt 580081 cgggaaaaaa ggctcttcag gtaagaaact tggacattgg gattgtgcga ccaaaatcgg 580141 atttgatgtt cctagaaacg ggacaaaaat cagagcttat gcaaaagcga agcctaaaaa 580201 ggtgattacg gtttataaaa atgatgttgg cagaatgcct aatgcagtgc tggatgttag 580261 ccctaaagcg tttaaagcgc ttggataccc attaagcaaa ggtaaagtag cggggcatta 580321 cagctattaa tgtacatata taatctggaa agcaagaagt cacattcttg ctttttctat 580381 tggtggagat aaaagatgaa aaaaagaatc atattattat tagcagtgat aatagcggca 580441 gctgccgcgg gggttgcgtt ttatgttgca aaggataaag gccatgagaa ggctgctgat 580501 gtttcagtca ataccgaaag cggtgatgag ctgctggttt caattacaga tacggatctg 580561 ctgacaaagt attatgaaaa tgacaaggtg atccatgagg agaagctgac cagctatccg 580621 gcatttgcct tggatcaaaa acagcaggtg ctctattata cgggcaataa tgaacagaat 580681 gaaatgaggc tttttaaatt ggatctgaag tctcataaaa aaacgatgct ttataaaggc 580741 gcggagagtg cggacagttt atttttatca aaggaccgtt caaccatcta tttccgctta 580801 ggaaaagcgg acgaaagcaa ttttcgaatc gccgcttttg atctgaagac gaaaaagtat 580861 aaaaatcttt atcctgccgc taatgatcag gatgacaccg tcagcagctt cttttataac 580921 caaaaaaacg attcatttgc attgcttcat tattctgtag aagaagacta caagaaaaca 580981 gatgaagcaa acgaaaaggg catcgaccct gaaccgacaa cgattcattt tgcggaaggc 581041 cgccaaaata aatttaatga gctgaaaagc ctgaaccaat ttatcagcga tattgctgtt 581101 tctgatgatg ataaacgtat tttattcaca tcatatacgc aaaaaggaac ggagcaaacc 581161 gcttctattc aaatgctcaa tgcggatacg aaaaaatatg aaagcatcat ctcaaatcaa 581221 aaatcattta agctgttaat tgacgcacag cctcagtttt ctaaggatgg gaagaacatt 581281 tattttcttg ccgaagccaa gggggctaaa aagctgaagg acgaaacagg gcgtgaagct 581341 aaggtgcgga cgatttattc ctatagcctt gagaataaga ccttcaaaaa agtatgggaa 581401 aatccgaacg gcatcatcaa cagctttttt gtgattaact aataaaaacc actcggcatg 581461 agctgagtgg cttttttaat ggatgaggtg cagggctaat gatccgagcc atttaaagat 581521 atgaatcaga ggtaccgaca aaaacagaag ttcaacatat gagttcattg caacattcag 581581 ctttttgaac gcagctcttt ttttcaagtc tttttgctgc tggtttgaga tcacgttatc 581641 actcctctta tatccatatt ataccattaa aacagacaaa aaagccctaa acgtttacag 581701 ttttgggctt ctttcttcgt atttggcctc ttgcaatgag aggcttttat tctgaaatat 581761 agaattttgt ctccgttcgg ggtttgtttg cttgcgggag actgcatttg ttatagggaa 581821 gaactagctt gttttcgttt ggctgttgtt ttggagattc actaatgaac ggatgccgtc 581881 gaccatttta cttccgcaca aagggcacaa tggcgtatca ctgctggcga agttttttcg 581941 ggtccagcca ttacagtctt cttttgtgca ttcccaagta ctcacatctt cctttggcag 582001 cggttcttga tttcgtttgt tatagtaaga cataaagtca cttcttccct catgtatttt 582061 actgcacatt tcctattgtc tcatactttt ccctaatctc ctaattcctt tttctttatg 582121 actttccaat aaccccatct aaaaaggaga ggagtgtgct gttaaaagca tctggctctt 582181 ctaaaaacgg gcaatggctg cttttaggaa aggtaacgag tgtcgcgttt ggaatattgc 582241 tgcgcaagtg ttccccagct gctgtagaga aaaatttctt gtcttccccg aagcacagca 582301 atgccggcac attgatgttt tggagggtgc cccggtaatc agcggccgtt tggttaaata 582361 aaatcgtgct agaaatggca gccggctgtt tgaggatttc tgccagcatc cattctgttt 582421 cggtctcggc aggcggttct gcgaacatat tctggatgaa gctttcgtag aaaggcagcg 582481 ggtcagtttg aatggcgtgc atcgctgttt ttaagccgtc aaaatcaaat ggaccatgtt 582541 cccagccctc ccattgatag tccgaagcgg attgatcgat gatcacagcg gcttgaatgt 582601 tatcattccc aaactgattg agataatccc atacgacaaa agcacccatt gaccagccgg 582661 caagaacgac atgatcaagc tccattgcat ttagaaattc ccttatgtca cgggcatatt 582721 gggaaatggt gtggccgtga agcactttgt cagattcgcc gtgtcctcta agatcaagac 582781 gaatacattg ataattggca gaaagcaccg aaaattgttt gtggaaaaat tgtccgctca 582841 tcagcacccc atgtataaac aggatcggcg tcccgctccc gtgtgtttca tagtaaaggc 582901 gtgtctgatc ttctaatatg atgtatggca tgtttctcct cctttagttt ccatcatgag 582961 tatggctggc tgctgttgag ctgatgatgg cagctgtcgc ggctgcctgc tgcgcttgaa 583021 tgactgtttc gatagcggtg tatagtcctg attccatcag cagatttttc tccatatgct 583081 cactgagata gaggctgaca gcaattttaa agttcatttc cttttgccat ttaaaagctt 583141 tttcctggtt taattcgtca gtgatgcaca aaacggtttt gatatctggc tcttccagaa 583201 atgtgaggag agcaaggtct ggataatgat aatcctttgt ttttttgaca gattcagtga 583261 tcgattgata tatctgtttg caagcggaaa caagcatttc gggctctttt tcactttgca 583321 aggccagaat atggctgacc tgatgtaagt actgtccttt tttaaagccg ttggctgcca 583381 gcagttgata gcatgtttcc gccttctgta gcgcctgcaa accttttccg ttttctccaa 583441 gcagtacggc aagcggaaca ttctgagttg aagtgaggaa ataatgattt ttcttcatct 583501 gctgataaac agctagcccc atgttcatct gttctttttg gtttgtcgtt tcagatttgc 583561 cggtgagcaa gatcagagcg gaaaggtatg tgaacatatc ccgcttatac cctagcttca 583621 ccatttcatt gtatacatcg atgaaagtct gaaatgtttg ttttgcctca tgctgaaaat 583681 gaatgtccag aatagatgca acagtaaagc ggtggtgtga attgagtgtt gagaagctgc 583741 cgatgtttga tttgatatag ctgctcaaat cataaaagcg ctgaaaatca aactctcttt 583801 tattcacaat atatgcagaa gaaatgagca ttaatatctg atcgtgtgaa actttccatt 583861 ttaattttgt ttttaattca gcataaatgg aaatgtaatg ctttgttttt tcatgtagat 583921 cgtgtgtgag cataaaaagc agctcctttt gttgttttta cgtaatacga taaatagggc 583981 caaaggtttc ataaagaaaa aacttgcctg ctagaggcaa gtttgtcggg ttatttatgg 584041 ggatcagtta tatccatcgg tctcatcatg tcatagtctt catgctctag aatatggcaa 584101 tgccatacgt atcgtccgct gtacggaccg aatgtcgccg cgattctcag gacttcacct 584161 gcatgcgctt gaatggtgtc tttccagccc ttttcacttg gcggcggcgg gacagccgga 584221 ccggtatagg acaattcccc gctttcttga taacgggcga tatcaaacgg ccgccggtct 584281 aatacacgga aggagactag atgcaggtgg atcggatgtg ttccgcgtgt cgggttgata 584341 atggaccata tttcagttgt gccgactttt ggtgtttctg tgacgggatc gtgccagcgt 584401 ttgttattaa gcagaaggac gggtctgccg tattcgtcct gggtgcctgc cagttttaac 584461 gttctgatgt tttgtattct ttcatgctgt accgaagggt atgaggcgag gtacttcggc 584521 tttctgcttt cgtctttttg tgccaatggt tttgtgactc tgaattgcat gatattcgca 584581 tctgtttcag gattgacgtc accgccgcag cccgcgctgt ttgccaaaat gatcgattct 584641 ccttcatatg ctgtgaagtc aatgatgata tcgtaacgtt cagcaggcgc aaggctgaaa 584701 gaattcagtt taacagatcg cggcaggagc cctccatctg aaccaatctg aataaaatct 584761 ccgccattat cgagtgacag gttataggtt cttgtattgg aggcgttgat gacacggaat 584821 cggtatttcc ttggctcgac ttccaagtat ggccatacct tcccgttgac gagtatggtt 584881 tctccgcaaa aagccggaac gattgaagga ttaggcagtg acggagaagg gttttccggt 584941 gcgctcggat aaaacaaaga accatcctca ttgatcgtgc ggtctgtgat aagaagcggc 585001 acatcgtatt cgtctgaagg cagttttaag cgtttttcct ttgggtcatg aatgatatat 585061 gcaccgacaa gtccggcata gacatttagc ctggtgagcg ccatggcgtg atcgtgatac 585121 cacaatatag ccccgcgctg ctggtttgga taatgataaa cctctctttt gaaataaggt 585181 cctgtttgtt caaagtcttt ggaaaaccaa gcctccggat acccgtcact atcatctggc 585241 gtgacgccgc cgtgtaaatg aacaacagtc tttacctcgg gctcttcatg ctggctgtca 585301 ctgtgatgaa tggtgtgatc aatcggaagg aaatgcgtgg aaggaaggtt attcatccat 585361 tttacatata cgttttcatt tcttttaacc tcaatggtcg gtcccggaaa taagccgttg 585421 tagccccaca ggcgggttgg agggagatcg cgatggagct gatgagtgca ttcctccatg 585481 gtgacttcgt agtatgtttt ttcttttgat tgctgtactg gctttagtgt atctgggatt 585541 gggagagcat ccacaaattt ttcaagtgtc attttcatct gtccttatct aaattttcca 585601 aattggtact atagttaatg acaataagga cgtgatggtt acaaaaaatc ttcgtgctgc 585661 agcccgcccg aagaagaaaa taacaaaatc ctaaacggca ggccgtttag gatttgatca 585721 gcattaaggc aggatatcgg gttgctgctg tgtgactggg ttggcagccg ctttctcgct 585781 caccttgcgt tttctgaaca caaggtaaga aatcagaacg attcccgtga tgacgcctgt 585841 cagcagcagc tcgtctctca tggaatcaat aaacgccatg gacactaaaa ttccgcaaat 585901 ggcgatgatg gtcaagtagg ttaggaaagg gaagagccac attttgatct tcaatgcttc 585961 tgggtttgtt ttttcgagtt ttttccgcat tttcagctgg gaaacggcga tgacaagata 586021 gacgagtaaa gcgattgcgc ctgatgagtt gactaagaat aaaaagacgg tatccggtga 586081 aaaatagttc attacgaccg cgatataaga gaaaaatgtc ccggccacaa tggcttgtac 586141 gggaacgcct tttttgctca atttcataaa acggcgcggc gcttcatttc tttctgcaag 586201 tgaatacagc attctggatg tggtatacaa acctgaattc aggcaagaga gtacggctgt 586261 gaggacgata aagttcataa tctgtgcggc tgcgggcact cctatatgct caagtacagc 586321 gacgaaaggg ctttctaaaa tatttgctga attccatggc aacagcgcca cgacaatggc 586381 gattgagccc acgtaaaaga cgatgatgcg ccatacaacg gatctggtgg cttttgtcac 586441 agattcgatc gggttggatg tttcccctgc tgcaatggca acgatttcag ttcccataaa 586501 agagaagatg acaacgacaa tgccgagcaa tacggagctg atgccctccg ggaaaaatcc 586561 gcctttgcct gtaagattcg aaaaaccgac tggctcactg cccggtgcaa agccaaaaat 586621 aaaggcaaaa ccaacgatta gaaaagcaat gatagtcaca actttaatga gggagaacca 586681 atattcaaac tcaccgaaag acttaacgga gtagacgttt gtcagggtga gcacaatggt 586741 caagatcaaa cttgtcagcc acagcggaat atcatggaac cagtattgaa taatgccagc 586801 accggcaatg gcttcgatcg ctatgacgat cacccagaaa aaccagtaca gccagccgat 586861 tgtaaatcct gcccacggtc cgatggcgtc gtgagcgtat tgagaaaacg atccgctcgt 586921 cgggtttacg gcagacatct caccgagcat tctcataata aaaatcacca ataatccggc 586981 taacgcgtaa gaaacaacgg cacccggacc ggtcgagtga atcactgaac cgctgcctac 587041 aaataggccg gctccgatta caccggcaat cgaaatcatt gtcatatggc gggtctttaa 587101 ttcctttttt aatcctgatt gagactggtt cataagttac ctccttttaa aatgcaatca 587161 ttactgaata ttatgataat tgaaactcta tcataaatat acagtttgtc gaaaattcgt 587221 gtaagaaaat ataccagctt atttcaaatt tgtagtgttt tgtttgcgct ttcagcgaat 587281 gtgtggaaaa aatgtttcgt tttttattcg ctgtgtgatt ttgcgtaata tttacaattc 587341 gatagaatgc gagaagcact ggtgtccttg ggtttgatgg gatttttggc ggagcaaata 587401 aattggatga gagaaaaagt gttccttcgt cactattttt ctgtggcggg tgaatcatgt 587461 ttctgtagac ccactgcgga tcagctttgt aagataataa taggaaaatg tgagcgagag 587521 gaggttttgt atggagagat atgatgaact gaaaaaggga gaatccggag cgctggtcag 587581 cattgccgcg tatctagttc tttccgcaat taaactgatc atcggttatc tttttcactc 587641 ggaagcactt acggcagacg ggttaaataa cacaactgac attattgctt ctgttgctgt 587701 gctgattggc ctgcgcatct ctcaaaagcc tcctgacgaa gatcatccat acggccactt 587761 tcgagcggaa acgattgcat cgcttatcgc atcgtttatt atgatggttg tcggactgca 587821 agtgctgttc agcgccggag aatctatttt ttctgctaaa caagagacgc cagatatgat 587881 tgcggcttgg acggcagcgg gcggggcagt cctgatgctg atcgtttacc ggtacaataa 587941 aaggctggcc aaaaaggtga agagccaggc gctccttgct gcggctgctg ataataaatc 588001 agacgcattc gtcagtatcg gcacatttat cggcattgtg gctgctcaat tccatcttgc 588061 ttggattgat acggtcactg cgtttgtgat cggtctgctt atttgcaaga ccgcatggga 588121 tatctttaaa gagtcatctc actctttgac agatggattc gacataaagg acatttccgc 588181 ttataaacag acaatcgaaa aaatctccgg tgtgagccgt ttaaaagaca taaaagcaag 588241 atacttgggc agtacggttc atgttgatgt ggtggttgag gtatcggcag atttaaatat 588301 tacggaaagc cacgatatag ccaatgaaat tgagcggaga atgaaggagg agcatgcgat 588361 tgattattcg catgttcata tggagccttt agaacaaaaa taatggagct tcctgtcaca 588421 ggaagcttca gcgtgtcgac aaaccctcgc attcgttgtc aggtctgcgc ttcggtgctc 588481 acgaattaga acattcgctc cgctcctatg ctcgtccttc ctagacttca agggttttca 588541 atcacgctga aaagatgaca aaaccctaaa atgaaagcca ttttaggatt ttgtcaacaa 588601 tctggagctt cctgccacag gaagcttttt tgtgtgtttt ggccagcttt attggtaaca 588661 atttgctaga atcgtttttt tatacagatt gctttttgtg gtaaagttag gttacattat 588721 gatgaatttt gtagatgact aggaggaaaa taatggcata tcaagaagac ctgcatcctt 588781 tgctggggaa agcagttgaa catattaata gagtaatggt tggaaaacga gacatcgcca 588841 tactcagctt agcagccctt cttgccaaag ggcatgtgct gcttgaggat gtacccggag 588901 tcggaaaaac gatgatggtc cgcgcgctgg caaagtcaat cggcgccgat ttcaaaagaa 588961 tccaattcac tccggatttg ctgccatctg atgtaacagg ggtatctatc tataatgcga 589021 aaacgatgga atttgaatat cgtcccggcc caattatggg aaatatcgtg ctggcagatg 589081 aaatcaaccg tacctctccg aagacacagt cggctttgct cgaagcgatg gaagagggga 589141 gcgtcacggt agatggccat acgatgcagc ttgccgatcc gttttttgtg atggcaacgc 589201 aaaacccggt cgaatatgaa gggacctatc ctttgccgga agctcagctt gaccgttttt 589261 tattcaaact tcggatgggt tatccgtcct ttaatgaaga gcttgacgtc ttatctcttc 589321 aggaaaaaag ccatccgatt gagacgcttg agccggttat tgcaaaagaa gacttcatct 589381 ttttacagag ggaagtgcaa aatgtccgtg ctgatgacag cattaaggaa tatatcgttg 589441 aaattgtgca gaaaacgaga cagcatcctt ctgttcaatt aggcgtcagt ccgcgcggct 589501 caatcgccct catgaaagcg gcacaggcat acgcgctgct gcatcatcgc gactatgtca 589561 taccggatga tattcaatat ttagctcctt tcacgctgcc gcaccggatg atgcttcatc 589621 ctgaggcaaa atttgaaggg attcaggcag aagcgatcgt aagggagatc atgtcagctg 589681 tgaaggtgcc ggttcaaagg tcggcggtcc gctgatgaat aagaaatggc aatggctcgt 589741 atatggttgg aagctgatta tattaacttt attgacggct gctgtttttt cttatgcgat 589801 gtttcagggc ggctttgtca gctggttttt gttttacgcg tttctccctt ttgtcttgta 589861 tgccgggctg ttggccttgt atccgctccg ttcttttcag gcttcaaggc aaatggataa 589921 aacacaattg catgcggggg acaggctggg cgtaacggtt acgctgagaa gaaagctgcc 589981 atttccgctg atgtatatgg tgattgaaga ttgcctgcca gaaggtatcg agtcattaaa 590041 tcgagacgga gccgcggcca aacggctcgt ttttccttgg tttaaacgga gcatgacgat 590101 gtcgtatgaa ttagctcggg taccgcgcgg agagcatcac tttcattctg tcagggtgcg 590161 aaccggggat gttcttggct tgattgaaaa aacagcattt tttgagctgg atgatacctt 590221 gtttgtttat ccattctatc agcgtttttc ctatcaggtg aatgagaggc atcaggaaga 590281 cggtgtaagc ggttcttctc ctattcatca gcaccattcc tcagtcgcag caagtgtgcg 590341 gaattatcag ccgggagacc ggtttgctgc gttagattgg aagacatctg cacggcggag 590401 ccagctgatg acgaaggaat ttgagccttc tcgcagcaaa aatctgtttc tgctgatgga 590461 ccgtttttcc tcagacgcat tcgaagaggt cgtttcagtg acagcttcga ttcttcattc 590521 tgttttaaaa aacggcgcgg gtgctggtct ggcttccatc gggaaggaaa aaaacatttt 590581 ccctattcag gaaggggatc agcattttaa gcacatgctt cggcatttag ccatcgctca 590641 ttgtgatgcg gcagacccga taagccgata tgcacgggaa gagctgggaa agccatctgt 590701 tcgccaagct gatcaagttg ttgtcacggg acagttaacg gaagatatgc tgcacctcgc 590761 agaaatagga ggcggccggg ttacggtgat actggcaaaa gagaaagatg ctgagctctc 590821 tcaagctgaa aatgtcatga ttgaacgcat gatgaaacgc caaatcagag ttcggatcat 590881 gaggggcggg cgagtttcgc gtgttgttta gaaagagagg tgactggttc acatgccgca 590941 cgatgatcac aagggaagcc gtttgagctt gctgttattt tattttctgg cttttttatt 591001 gctgtgggag tggcttaggc cgcttgacag ttttactgaa acgaaacata caggcttttt 591061 tagtgtcttt atcggcttga cgtttctgct gacttttttc aggatgaggt ggtttgtcac 591121 cgttcctttt tgtgtcatat ttacattgat ctcgatacac atcctgtttt atcaaggatc 591181 tatattcgac ttgagctggg tcagctcttt tttgcaggat gtctatctga atatcacgct 591241 gattcaatca gggcaatgga atgacatgat tccttcattt cggaccctgc tgttttttgt 591301 gctgctgtgg ctgctggtct atctcctgca ttattgggtg atttaccaga gaagaatttt 591361 gtttttcttt ttgatgacag tagcgtatat tacgattctt gataccttta cgccatatga 591421 tgccactttt gccgtaatcc gtatcgtgct gatcggcttc tttatgctgg gccttttata 591481 cttggaacgc attaagctga tggaaagaat cacactgcca aaaacatctg tcctgaaatg 591541 gtttcttcct ttatctgtat tggttttggc tgcaacggga ttcggactcg ccgctccaaa 591601 atcagagccg gcttggcctg atccggtgcc ttttcttaaa aaaatcactc atcaagaccg 591661 cgtgtctgca ggggaaagca aaatcggata cgggaatcat gatgaatcac tcggcggccc 591721 gttccagcag gatgctacac ctgtttttac atggcaggga aaagagcgta cgtatttccg 591781 tgtggaaacg aaggacacgt ataccggaaa aggctggatt gaaacagaca caggcatgtc 591841 gtatcagctt agcaatggaa aagttgaaaa tctgtggttt gaccataagg ttgcgacaga 591901 gcgccgcacc gtccgtgtaa aagtcgataa gcactacggg tataaccatc tgatgtatcc 591961 gattggtgcg gaaaccattc agccaaagca ggctgtctca cttgaaatga acggcaacac 592021 ggagcaaatt tctccgatca gtgaacaagc cggtgaaatc agaaatatgg ggaattatac 592081 agtaacgtac aattccccgg tctataagct ggatgaactg agaaaggtaa aagtgagaaa 592141 aaacagtgag gagtacacat tcagcgatcg ctacatgcag cttccagatt cactgccaga 592201 gcgggtgaga acccttgcga tcaaactgac tcaggatcac gacaatatgt ttgataaggt 592261 gaaagcggtt gaggactatt tagggtcaaa tgcgttcaca tatgaaacag aaaacgtgac 592321 cattccgaag aatgatgaag attatgtcga tcaatttctc tttgaaacga aaatgggtta 592381 ttgtgataac ttttcttccg ccatggtggt gctcttgcgc tcggccggca ttccggcccg 592441 ctgggtaaag ggttatacgt ccggcgaata caaagaagca gggaacaaaa atggcagcat 592501 ttacgaagtg acaaataaca atgcccattc ctgggtagag gtgtatttcc cggaacaggg 592561 ctgggttaca tttgagccga ctaaagggtt tacaaatccg gctcaattta catcttctga 592621 cacaaaagac tctggcagcg atagcagcag ctcgccgaag aaagcaaaag agaaacagaa 592681 agaagagaaa aaacagccgc aaaaagagga aaaacaaaag gaaaagcggg agccagctgt 592741 ttctaaaaag ccgtccgctt cgcatactaa tgccggtgcg ggcttgtatg cagcgcttgc 592801 ggttcttgca gtcctcctgg tggcagctgt attgctgtat gttttccgct cgttatggat 592861 tcctgttttc gccgtgagga aattgaagcg gcgcagtgat cagcacgcgt tttttgaggc 592921 atatggcgcg ctgctgaaac aactgaagag aaaaggactg ccgaaacgag acagtgaaac 592981 gctgcgtgat tatgcaaaac gaattgatga aaaatacgac atagaagaca tgtcaaagct 593041 gacattaagc tatgaaaggg cgctttacag aaatgaagat tcttcggcgc tatggaatga 593101 ttcgagagag ttatgggaaa atttaattaa aagaagatgg tcttgaccgc ttatcgacgt 593161 gttgttagaa ttagtgaata ttatcggagt ctgggagcga gttggcctga ctccggcaaa 593221 cggccttgcc aaagagggcg gagcgagctt catatctgtc ctcgtttttt tctgtgtcaa 593281 aaaacttaga ggagattagg tgacaaccat gacaaagtta gtgaatgaaa tgattcttgt 593341 ccttgatttc ggcagtcagt ataaccagct gattacacgc cgtatccgtg aattcggtgt 593401 ttacagcgag ctgcatccac atacattgac ggctgaagaa attaaaaaaa tgaatccaaa 593461 aggaattatt ttatccggcg gtccaaacag tgtgtatgat gaaaactctt tccgctgtga 593521 cgagaaaatc ttcgagcttg atattcctgt tttgggaatt tgctacggca tgcagctgat 593581 gactcattac cttggcggta aagttgaagc ggcaagccag cgtgaatacg gaaaagcaaa 593641 catccgcatc gaaggcacac ctgatttgtt cagagatctt ccgaatgaac aagtggtttg 593701 gatgagccac ggcgatttgg ttgtagaagt tcctgaaggc ttcactgttg acgcgacaag 593761 ccatcactgc ccgaactcag caatgagcaa agcggacaaa aaatggtatg gcgttcagtt 593821 ccacccggaa gtgcgccact ctgaatacgg caatgatctt ctgaaaaact ttgtattcgg 593881 tgtttgcgaa tgcgaaggcg aatggtcaat ggagaacttt atcgaaatcg aaatgcaaaa 593941 aatccgtgaa acggtcggag acaaacaggt tctttgcgcg ctaagcggcg gcgttgattc 594001 ctctgttgtt gctgttttga ttcataaagc gatcggcgac cagctgactt gtatctttgt 594061 agaccatggt cttctccgta aaggcgaagc tgagggtgtt atgaaaacat tcagcgaagg 594121 ctttaacatg aatgtgatta aagtagacgc aaaagatcga ttcttaaaca aactaaaagg 594181 cgtttctgat cctgagcaaa aacgcaaaat catcggtaat gaattcattt acgtgtttga 594241 tgatgaagcg gacaagctca aaggcatcga ctaccttgca caaggtacgc tttacacaga 594301 tatcatcgag agcggtacag caacggcgca aacgatcaaa tctcaccaca atgtcggcgg 594361 acttcctgaa gacatgcagt ttgagctgat cgagccgtta aatacgctct tcaaagacga 594421 agtgcgcgcg cttggcacag agctcggcat tccggatgaa atcgtatggc gtcagccgtt 594481 cccaggaccg ggactcggaa tccgcgttct tggcgaagta acagaagaaa aacttgaaat 594541 cgttcgtgaa tcagatgcaa tcttgcgtga agaaattgca aatcacggct tagagcgtga 594601 tatctggcaa tacttcactg ttcttcctga catccgcagc gttggtgtta tgggtgacgc 594661 aagaacatat gattacacaa tcggaatccg cgccgttaca tcaatcgacg gcatgacatc 594721 tgactgggcg cgtatcccgt gggatgtgct tgaagtcatt tcgacacgta tcgtaaacga 594781 agtgaagcac attaaccgcg tggtgtatga tattacaagt aagccgcctg cgacgattga 594841 gtgggaataa gaatcaatta atggaaacca tctttttggc aattttgccg ggaagatggt 594901 tttatttgtt tattacgaac aaaatccgat tttgcgcgac tattgttcgc tttttgtatt 594961 gttttttcaa aatgaacttg gtacaataga cacagaaatc aaataagatg aattcgtata 595021 atcgcgggaa tatggctcgc aagtctctac caagctaccg taaatggctt gactacgtaa 595081 acatttcttt cgtttgatat aaataaaaca cggttattta ttcaaactga aatccgtctg 595141 tagtcaagcg tcccaaaatg tattgggacg ttttttattt ggcgttttca ggacagaata 595201 aatagcaaag agtgaaggga gtcaaatagc ttgaaaacgt tttttcagtt tgatgagctg 595261 ggcaccagct atcgcaatga aatcattggc ggattaacga cttttttatc tatggcatat 595321 attttgttcg tcaatccgat tacgcttgct ttggagagcg tgaaagattt tccggaggcg 595381 ctgagaattg accagggtgc ggtctttacg gcgacagcgc tggcgtctgc agcaggctgt 595441 atcttaatgg gattaatagc gagatatccg attgccatcg cgccgggtat ggggctgaac 595501 gcgttttttg cgttttctgt tgtccttggt atgggtattt catggcaggc agctttgtcc 595561 ggtgttttta tttcaggtct tattttcgtt gctctttctt taacaggttt tcgtgaaaaa 595621 atcatcaacg ccattccgcc tgagctgaaa ttggcagtcg gtgcggggat cggcctgttt 595681 attacatttg ttggattaca aggttcagga atcattacag cgaatccttc tacgctcgtc 595741 acgatcggaa acattcacag cggtcctgtg ctgttaacga ttttcggtgt gattgtcacg 595801 gttattttaa tggtgcttcg cgtgaacgca ggcgtgttta tcgggatgct attaacagcg 595861 gtagccggca tgattttcgg tttggttccg gttccgactc aaattatcgg cagtgtgcca 595921 agccttgcgc cgactttcgg acaagcgtgg attcacctcc cggatatttt ctctgtacaa 595981 atgctgatcg ttattttaac attcttgttt gtcggatttt ttgatacagc tggtacactt 596041 gttgctgtgg caacacaagc tggtttaatg aaggaaaaca aattgccgcg tgcgggccgt 596101 gcgcttttag ctgattcatc ttctattgtg atcggtgccg tgcttggtac gtctacaaca 596161 acttcttacg tggaatcaag ctcaggtgtc gctgcgggtg cccggtcagg atttgccgca 596221 attgtaacag ggattctctt tttactggct acgtttttct cgccgctcct atcagtcgtt 596281 acgtcaaatg taacagcgcc ggcgcttatt attgttggtg cattgatggt ggcgccgctt 596341 ggcaaaatcg cttgggataa gttcgaagtg gccgttcctg ctttccttac catgatcatg 596401 atgccgttaa cgtacagcat cgcgactggt attgccatcg gatttatttt ctatccgatt 596461 acaatggtgt gcaaaggaaa agcaaaagag gttcatccaa tcatgtacgg gctgtttgtc 596521 gtatttatcc tgtactttat cttcttaaaa taaggaatga aaaaccagct gcactggcag 596581 ctggtttttt tgttgcaaaa gataaaacca tttcatacga tataccgtca tgtagatgtg 596641 ccgccatgct ttacttaaat ggaaatgact tgactgttca ggaaggcttc ggtaccttat 596701 ataagtgttt tattttcttg ctgaatggta ttccgccgta tttttttgat aggagttgct 596761 gacatgacgg aagaaagaaa agaaacgttt gaagaagaaa ttaaccagag tgaaagaata 596821 gatgcagatg aagaaccgct atcgagaatg tccagaaagg cgagccggca aagcaagcag 596881 aagcaaaaac aaaagcagaa accgcgccag gaacgcggtg aatcaactgt taaagacaag 596941 cttgcgtctg tttgggcagc catcaacaga tattgcggtt ttgcgttctc gattttaaaa 597001 tctccggcga aaactgtcgt aacggatggt ttttctcatt ataagtacgg tctgatttca 597061 atgcttatat tcagtatcat tttttcaatt gggaattggt ttcagttaaa ggcaagctgg 597121 aatcggccgc tcggtttcgg agaacgccat catgctttct atgacgggtt tttagttgtt 597181 cttgtgtatt tgctgatctt tttcgcggta atggtctttg ctatatgggc tgtctcccgc 597241 tatatgatga agcagaaggt gacgttcaga gaagcggctg ccgtattggg ttcattgctt 597301 gtacccgtaa ttgctgtttc aatcctttgg ctgatctttg cgatcgtaaa tatcccaatg 597361 ctgacagtac tgtttacggt gctgatcttg ttttccatct tttttatcat cgcgctgtat 597421 gtacagcgtg tgtaccaggc ggcacaagat gcaccaattg attatatcta ttgtgtattt 597481 gcagtagttg cgatagcgct gctgtttacg gcagtgactt ggccgtttat ttctgaatat 597541 attacggcgt cgttgattcc gctttaatga aaaaaccggc taatcctagc cggttttttt 597601 atgtcacact ttttacaaat atatctaaaa aacatagttg atttgtagga ttaacccgtg 597661 tatgatgggg aaaatgctga aaacgtccag cgcaaaaacc tttatgttta aggaggatga 597721 tggacatggc tgatgtactt cgccgagcaa ttaaccaaaa gaagcaattt ttaaaaacca 597781 aattactgct ctcggaattt tatcaaggaa gaggggaaca gcttgctgac tacacgctga 597841 gtgagcttga gaaagaatac aagtcccttc agaaaatgaa aaaagagatc tgacaataga 597901 tataaagagg tgagtctgct gaaaagcggg cttttttgtt ttgattttga aaaggcgaga 597961 aagagggtaa actactactg ttcaacacat aaaagcgtgt cgaaatattt tgcttaagct 598021 tacgggcgaa gctgattgta aacggctcat ttctctagta gaatatgaat gctttgtgca 598081 agctgaagag tagggggatg aataaaatga tgcaaaccat cttatcaaat gggatagcca 598141 tggttctcat aattctcatt attaatattg tctatgtgtc attttttacg ataagaatga 598201 ttttaacgct gaaaggacag cgttatttag cggccggcat cagtacgatt gaaatactgg 598261 tttatgtgac aggactgagt ctggtgctcg ataacttaga ccagattcaa aatgtgatcg 598321 cgtacgcgct cggttacggt cttggcgtaa ttgtcggcat gaaaatagaa gaaaaattgg 598381 cgcttggcta tattatggtc aatgtgatta cgaaggagct cgatcttgat cttccgaagc 598441 agctccgtga aaaaggctac ggcgtgacaa actgggtggc aggcgggctt gaaggcgacc 598501 gcacagccct tcagatcctg acgccgagaa gatatgaact ccagctatat gatacgatta 598561 aaacacttga ttcaaaagcc tttattattg cgtacgaacc aaaaacaatc cacggcggct 598621 tctgggtcaa agcggtgaag aagaggagaa ttaaagaata atggcaaagc cgaagaagaa 598681 aaagtttgaa gtgacagagc agcaaacgat tgatgcggtg cttcagcaaa tgaaagaaga 598741 aggatatctg cctgtaaggc gaatggaaga gcctattttt atggaaaaaa aggaaaatgg 598801 gtcaattcag atcgttccgt gcgggaaaaa aatcgtattt gaagggaaat tgatctaaaa 598861 cacgaacatt agtagaatga atttttgtat cgttcgataa tatcgttgac attatccatg 598921 tccgttgtta agataaacat gaaatcaaaa cacgacctca tataatcttg ggaatatggc 598981 ccataagttt ctacccggca accgtaaatt gccggactat gcaggaaagt gatcgataaa 599041 actgacatgg atatatcgca gaagcgaacg actgacgata catgtaccat gcccggtttg 599101 tattgcttcc tcataagtgc aatgcagagc gggtattttt tattttctga aaacaaaagc 599161 attagaaggt ggggaacaga atgcagccgc tagtaggaat catcatggga agcacttccg 599221 attgggagac aatgaaacac gcatgcgaca tacttgacga actcaatgtt ccgtacgaaa 599281 aaaaggtcgt ttccgctcac cggacgcctg atttcatgtt tgaatatgct gaaactgcta 599341 gagaaagagg catcaaggtg attattgccg gtgccggagg agcggcgcat ctgccaggga 599401 tgacggctgc gaaaacaaca ctgccagtca ttggagttcc ggttcagtcc aaggcgctga 599461 acggaatgga ttcacttctt tccatcgtcc aaatgcctgg aggcgtgcct gttgcgacaa 599521 catccatcgg caaagcgggt gctgtgaacg caggcctgtt agcggcgcaa attttgtcag 599581 catttgacga agaccttgcc cgtaagctgg atgagagaag agaaaataca aaacagacag 599641 tgttagaaag cagtgatcag cttgtctaaa caaatcatct atccgggagc tgtaatcggc 599701 attatcggcg gcggccagct tgggaaaatg atggctgtgt ccgccaaaca aatggggtat 599761 aaagtcgcgg tcgttgatcc ggtgaaagat tcgccgtgcg ggcaggttgc ggatgtcgaa 599821 attaccgctc attataatga ccgtgaagcg attcgaaaat tggctgaaat cagcgatatc 599881 atcacatatg agtttgaaaa catcgactat gatgcgctgc attggctaaa agatcatgcg 599941 tatctcccgc aaggaagtga gctgctgctt attacccaaa accgtgaaac agagaaaaaa 600001 gcaattcaat ccgcgggctg tgaagtcgca ccgtacagca tcgtcaaaac aaagaatgaa 600061 ttgaaacagg cagtacagga gctcaggctt ccggcagtgc tgaaaacatg ccgcggcggg 600121 tacgacggca aaggccaatt tgtgataaaa gaagaggcgc aaatggagca ggcagccgct 600181 ctgttagaac acggaacttg cattcttgaa agctgggttt cttttaaaat ggaactgtcg 600241 gtgatcgtcg ttagatcggt aaacggtgaa atttcaacat ttccgacagc tgaaaacatt 600301 caccacaaca atattctttt ccaaagcatc gtgcccgcac gggtagagaa agggattcag 600361 cagaaggctg ctgatctcgc agttaagctt gcagatgagc ttaaccttgt cggaccgctt 600421 gctgttgaga tgttcctgac agaggacgga gagcttttgg tcaatgaact ggcgccaaga 600481 ccgcacaatt cagggcatta tacgctggac ctttgcgaga cgagccagtt tgagcagcat 600541 atcagagcgg tatgcgggct tccgcttggg aagacagatt tgctgaagcc gggcatgatg 600601 gtgaatcttc tcggcgatga agtgaagctt gttgaggaag acccggagct tttaaaagag 600661 gcaaagctat atatatacgg aaaacatgaa atcaaaaaag gccgcaaaat ggggcatatt 600721 acatttatga agcagcctga agacgaatgg attcaggaga tcacaaataa atggatgaat 600781 agagacggag gacaagcaga atgatcgaac gttattcaag acctgaaatg tccgcgattt 600841 ggacggatga aaacagattt caagcatggt tagaggttga aattcttgcc tgtgaagcgt 600901 gggcggagct tggcgtcatt ccgaaagaag atgtaaaggt tatgcgcgaa aacgcgtcat 600961 ttgacatcaa ccgcatttta gaaatcgaaa aggacacgcg ccatgacgtt gtcgctttta 601021 cgcgcgctgt atccgaatca ctgggcgaag aaagaaaatg ggtgcattac ggcttaacgt 601081 caactgacgt tgttgatacg gctctttcct acttattaaa acaggcaaac gatattttgc 601141 tcaaggatct tgagagattt gttgacatta taaaagaaaa agcgaaagaa cataaataca 601201 cagtcatgat ggggcgcaca cacggcgtac acgctgagcc tacaacattc ggcttaaaac 601261 ttgcgctttg gcatgaagaa atgaaacgta atcttgagcg cttcaaacaa gcgaaagcag 601321 gcatcgaggt tggaaagatt tccggtgctg tcggcacata tgcgaacatt gatccatttg 601381 ttgaacaata tgtctgtgag aagctcggat tgaaagcagc accgatttcc actcaaaccc 601441 ttcagcgtga ccgccatgct gactatatgg caacacttgc tttgatcgcg acaagcatcg 601501 agaaattcgc tgtggaaatc cgcggactgc aaaagagtga aacacgtgaa gtagaggaat 601561 ttttcgcgaa agggcaaaag ggttcatctg caatgccgca taaacgaaat ccgattggct 601621 ctgaaaacat gacaggcatg gcgcgcgtga tccgcggcta catgatgaca gcttacgaaa 601681 atgttccatt atggcatgag cgcgatattt ctcattcttc agcagaacga attattcttc 601741 cggatgcgac aattgcgctg aactacatgc tgaaccgctt ctccaacatc gtgaagaact 601801 taacggtctt cccggaaaac atgaagcgca acatggaccg cactctcggc cttatctatt 601861 ctcagcgtgt gctccttgct ttgattgaca caggcctgac tcgtgaagaa gcctatgata 601921 cagttcagcc gaaagcaatg gaagcgtggg aaaaacaagt gccgttccgc gagcttgtgg 601981 aagcggaaga gaaaatcacg tcacgtcttt ctccagaaaa aattgctgac tgctttgatt 602041 acaattacca tctgaaaaat gttgatctga tctttgaacg tttaggttta gcatagaaga 602101 agcttttagc ggcttcttct aagccgccgc agtttgaaaa ttcccaacat tcgggttagg 602161 aggccttccg tgaatattgt gaagaatgaa cttttatacg aaggaaaagc aaaaaagatc 602221 tacaaaaccg atgacgaaaa cacgctgtat gtcgtgtata aagactccgc cactgccttt 602281 aacggcgaga aaaaagcaga aatcagcgga aaagggcgct taaataatga aatttcaagc 602341 ctcattttca aacaccttca tgctaagggc attaacaatc attttatcga gcgcatttcg 602401 gaaacggagc agctcattaa aaaggtaacg attgtgccgc ttgaagtcgt ggtaagaaat 602461 gttgtggcag gaagcatgtc caaacgtctc ggcattccag aaggcacgga gcttgagcag 602521 ccgattatcg agttttacta caaggatgac gcgctgggtg atccgctcat cacagaagat 602581 catatttggc ttttgaaggc ggcgactcct gagcaggtag aaaccattaa gtccattaca 602641 acaatagtaa atgaagagct tcaaagcatc ttcgacgatt gtcatgtcag attaatagat 602701 ttcaagcttg aattcggttt agatgcagaa gggcaagtgc ttttggcgga tgaaatatct 602761 cctgacacat gccgcttgtg ggataaagaa acgaacgaaa agctggacaa agatttattc 602821 agacgcaatc tgggaagctt aaccgacgca tacgaagaga ttttcaatag actgggaggc 602881 attcatcatg tataaagtaa aagtttatgt cagcttaaaa gaaagtgtac tagatccaca 602941 agggagcgct gtccagcatg ccttgcacag tatgacttac aacgaagttc aagatgtgcg 603001 catcgggaaa tacatggagc ttaccattga aaaatctgac cgtgatcttg acgtgctagt 603061 gaaagaaatg tgcgaaaaac ttcttgcgaa cacagtgatt gaagattata gatatgaggt 603121 tgaggaggta gtcgcacagt gaaatttgcg gtgattgtgt tacccggctc caactgtgat 603181 atcgatatgt atcatgctgt aaaggatgag ctcggccatg aagtggaata cgtctggcat 603241 gaggaaacaa gccttgacgg cttcgacggc gtgttaattc cgggaggatt ttcttacggc 603301 gattacttaa gatgcggcgc catcgcccga tttgcgaata ttatgccagc tgtcaaacaa 603361 gcagcggctg aaggaaaacc tgttcttggc gtctgtaacg gattccagat tttacaggag 603421 cttgggctgc tgccaggcgc aatgagacgc aacaaagatc tgaagttcat ttgccgtccg 603481 gttgaattga ttgttcagaa cgacgaaacc ttattcacag cttcctacga aaagggagaa 603541 tcgattacaa tcccggttgc ccatggtgaa gggaatttct actgtgatga cgagacgctt 603601 gctacattaa aggaaaacaa tcaaattgct ttcacatacg gctctaatat taatggaagt 603661 gtcagcgaca ttgccggtgt cgtgaatgag aaaggcaatg tattaggcat gatgcctcac 603721 cctgagcgcg cggtcgatga actgcttgga agcgccgacg gtcttaaatt gttccagtct 603781 atcgtgaaaa attggaggga aactcatgtc actactgctt gaaccaagta aagaacaaat 603841 aaaagaagag aaactgtatc agcaaatggg tgtcagtgat gatgagtttg cattgataga 603901 atccattctt ggaagattgc cgaactacac agaaatcgga attttttctg tcatgtggtc 603961 tgagcattgc agctataaaa actcaaagcc gattctgcgt aaattcccga caagcggcga 604021 gcgtgtgctg caggggccgg gggaaggcgc cggaatcgtt gatatcggtg ataaccaagc 604081 ggttgtgttc aaaattgaat cacataacca cccatcagct ctcgagcctt accaaggcgc 604141 tgcgactggc gtaggcggaa ttatccgtga tgtattctca atgggtgcac gcccaatcgc 604201 tgtattgaac tctcttcgat ttggtgaact gacttcaccc cgcgtgaagt acttgtttga 604261 agaagtagta gcgggtatcg ccggatacgg caactgtatc ggcatcccga cagtcggcgg 604321 agaagtgcag tttgacagca gctatgaagg aaatccgctc gtcaacgcaa tgtgcgtcgg 604381 tttaatcaac catgaagaca tcaaaaaagg ccaggcaaag ggtgtcggca acacagtaat 604441 gtacgtagga gcgaaaacag ggcgtgacgg catccacggc gctacgtttg cttctgaaga 604501 aatgtcagac tcgtctgaag aaaagcgttc tgctgtccaa gtcggcgatc cgtttatgga 604561 gaagcttttg cttgaagcat gtctggaagt catccaatgc gacgccttag tcggcattca 604621 ggatatggga gctgccggtt taacaagctc aagtgcagaa atggcaagta aagccggttc 604681 tggcattgaa atgaatcttg acctgattcc tcagcgcgaa acaggcatga ccgcgtatga 604741 aatgatgctt tctgaatcac aagaacggat gcttttggtt attgagcgcg gacgtgagca 604801 ggaaatcatc gatatttttg acaagtatga tcttgaagcg gtttctgtcg gacatgtgac 604861 agatgataaa atgcttcgcc tgacacataa aggagaggtt gtgtgcgagc tgcctgttga 604921 tgccttggca gaagaagcac cggtttacca taagccttct caagagcctg cttactatcg 604981 cgagtttttg gaaacagacg ttccggctcc gcaaattgaa gatgcgaatg aaatgctgaa 605041 ggcccttctt cagcagccga cgattgcgag taaagagtgg gtttatgatc agtatgacta 605101 catggtgcgc acgaatacag ttgtcgctcc tgggtctgat gctggtgttc tcagaatccg 605161 cggaacgaaa aaggcgctgg cgatgacgac agactgtaac gcgcgttatc tctatcttga 605221 tcctgaagtc ggagggaaaa ttgctgtcgc tgaagcagcg cgcaacatca tttgctcagg 605281 cgcagaaccg cttgcggtga cagataacct taacttcgga aaccctgaga agccggaaat 605341 cttctggcag atcgaaaaag cggcagacgg cataagcgaa gcgtgcaatg ttctcagcac 605401 tccggttatc ggcggtaacg tatcgcttta taacgaatca aacggcacgg cgatctatcc 605461 gacaccagtt atcggcatgg tcggcctaat tgaagataca gcgcacatta caacacagca 605521 tttcaaacaa gcaggagatc tcgtatacgt gatcggcgaa acaaaaccag agtttgccgg 605581 aagcgagctg caaaaaatga cagaaggccg tatttacggc aaagcgccgc aaatcgatct 605641 tgatgtagag ctgtctcgtc aaaaagcact gcttgacgcg attaaaaaag gcttcgttca 605701 atctgcgcat gatgtgtctg aaggcggctt aggcgtagcg attgcggaaa gtgtcatgac 605761 gacggaaaac cttggcgcta atgtgactgt agaaggggaa gcggcgttat tattctctga 605821 atctcaatct cgcttcgtcg tttcagtgaa aaaagaacat caagctgcgt ttgaagcaac 605881 tgtcaaagat gcagttcata ttggtgaggt aacagctgac ggaattctgg cgattcaaaa 605941 ccaagacgga caacaaatga ttcatgcgca aacgaaagag cttgaacgcg tatggaaagg 606001 agctatccca tgcttgctga aatcaaaggc ttaaatgaag aatgcggcgt ttttgggatt 606061 tggggacatg aagaagcccc gcaaatcacg tattacggtc tccacagcct tcagcaccga 606121 ggacaggagg gtgctggcat cgtagcgact gacggtgaaa agctgacggc tcacaaaggc 606181 caaggtctga tcactgaagt atttcaaaac ggcgaactca gcaaagtaaa gggaaaaggc 606241 gctatcgggc acgttcggta cgcaacggct ggaggcggcg gatacgaaaa tgttcagccg 606301 ctcctcttcc gttcccaaaa caacggcagc ctggcgcttg ctcataacgg aaatcttgtc 606361 aacgccactc agctgaagca gcagctcgaa aatcaaggga gcatctttca aacctcttcg 606421 gatacagagg ttttggctca cctgatcaaa agaagcggac acttcacgct gaaggatcaa 606481 attaaaaact cgctttctat gctgaaaggc gcctacgcgt tcctgatcat gaccgaaaca 606541 gaaatgattg tcgcacttga tccaaacggg ctgagaccgc tatccatcgg catgatgggc 606601 gacgcttatg tggtcgcatc agaaacatgc gcatttgacg tcgtcggcgc aacgtacctt 606661 cgcgaggtag agccgggaga aatgctgatc attaatgatg aaggcatgaa atcagagcgt 606721 ttttccatga atatcaatcg ttccatttgc agcatggagt acatttattt ctccagacca 606781 gacagcaata ttgacggtat taatgtgcac agtgcccgta aaaaccttgg gaaaatgctg 606841 gctcaggaat ccgcagttga agctgacgtc gtaaccgggg ttccggattc cagtatttca 606901 gcggcgatcg gctatgcaga ggcaacaggc attccgtatg agcttggctt aatcaaaaac 606961 cgttatgttg gcagaacgtt tattcagccg tcccaggctc tgcgtgagca aggcgtcaga 607021 atgaagctgt ctgcggtgcg cggggttgta gaaggcaaac gcgtcgtgat ggtggatgac 607081 tctatcgtgc gaggaacaac tagccgccgg attgtcacga tgctaagaga agcgggtgcg 607141 acagaggtgc atgtgaaaat cagttcaccg ccgatcgctc atccgtgctt ttacggcatt 607201 gacacttcca cacatgaaga actgatcgcg tcttcgcatt ctgttgaaga aatccgtcag 607261 gaaatcggag ccgataccct ctcatttttg agtgtggaag ggctgctgaa aggcatcggc 607321 agaaaatacg atgactcgaa ttgcggacag tgtctcgctt gctttacagg aaaatatccg 607381 actgaaattt accaggatac agtgcttcct cacgtaaaag aagcagtatt aaccaaataa 607441 aacttgaaaa atgacataaa ggcagcgcag ttcggctgcc tttctctttc tgccctcgtt 607501 cggggagata ttttgaaaag cgccttaaag gagtgaatag gatgtctgaa gcatataaaa 607561 acgcaggagt tgacatcgaa gccggatatg aagctgtaaa acgaatgaaa aaacacgtgg 607621 agcgcacgaa acggcttggc gttatgggca gccttggcgg ttttggcggc atgtttgacc 607681 tgtctgagct ttcttatcaa aaaccagttc tcatttcggg aacggacggt gtcggcacaa 607741 aattaaagct cgctttttcc atggataagc atgacacgat tggcgtggat gctgttgcaa 607801 tgtgtgtcaa tgacgtgctg gcacaaggtg cagagccgct gtttttcctc gattatttag 607861 cggttggcaa agcggaccca gtgaaaattg aacagattgt acaaggtgtt gcggaaggct 607921 gtgagcagtc aggttcagcc ttagtcggcg gtgaaacggc tgaaatgccg gggctctata 607981 cagctgatga atacgatatt gccggtttct cagtcggagt ggcagaaaag gacgaaatcg 608041 tgactggaga aaaaattgaa gagggccatc tgttgatcgg cctcagctcc agcggccttc 608101 acagcaacgg cttttccctt gtcagaaaag tgcttctgga tgatgcggag ctggacctcg 608161 atacaacata tgagccgttt gaacgcccgc ttggcgagga attgcttgaa ccgacaagga 608221 tttacgtgaa gcctgtgctt gccgcggtca aaagcggaaa aatcgacggc atggcgcacg 608281 tgacaggcgg aggatttatt gaaaatattc cgcgtatgct tccggaaggc ttaagtgcgg 608341 aaattgatca tggctcatgg ccgatcccgc cgattttttc tttcttgcaa gagtacggca 608401 agctaaagga agaagacatg ttcaacgtct ttaatatggg tatcggtttt gttttggcag 608461 tcaaagaaga gcatctgaca gatgtgatcg gaacgcttga aagccatggc gaaaaagcct 608521 atttaatcgg gcgtgtgaaa aaaggtgaag gcgtcacatt cggcggtgcg gcactttcat 608581 gaaaaagttt gcggtatttg catcaggaaa cggttcaaac ttcgaagcca tcgtcacgcg 608641 tttgaaggag gagaactggg atgcgtcagc agcgctcctc gtttgcgaca aaccgcaggc 608701 gaaagtcatc gaacgggcgg aagcattcca cattccatcc ttcgcatttg agccgaagtc 608761 ttatgaaaac aaggctgcat ttgaacaagc catcattgaa cagcttcgtc ttcacgaggt 608821 tgaattgatt gctcttgccg gctatatgag gctgatcggt gatacgctcc ttcaagcata 608881 tgggggaaaa atcattaaca ttcacccatc gcttcttccg gcgtttcctg gaatcgacgc 608941 agtcggacag gcgttccggg cgggtgtgaa ggtggccgga atcaccgtgc attatgtcga 609001 tgaaggaatg gatacaggtc cgatcatcgc tcaaaaggca atcgaaattg atgaacatga 609061 tacattggaa acaatcgaac agcgaattca caagcttgag cataaatggt atccgagtgt 609121 gattaaacag ctattaggat taaataacag aggtgaaaag gcatgaccat taaacgtgca 609181 ttaatcagtg tttcagataa aacaaatctc gttcctttcg taaaagaact gacagagctt 609241 ggcgttgaag tcatctccac aggcggaacg aaaaagcttc ttcaagaaaa cggtgtggat 609301 gtgatcggaa tttctgaagt gacaggcttt cctgaaatta tggacggccg gttaaaaacc 609361 ctacacccga atattcacgg cggccttctg gcggttcgcg gcaatgaaga gcatatggcg 609421 cagatcaatg aacacgggat tcagccgatt gacctcgttg tcgtcaacct ctatccattt 609481 aaagaaacga tttctaaaga agacgtcacg tatgaagaag cgatcgaaaa tatcgacatc 609541 ggcggacctg gcatgctgcg cgcggcatca aagaaccatc aggatgtcac ggttatcgtc 609601 gatccggccg attacagccc agtgctaaat caaatcaaag aagaaggcag cgtatctctt 609661 cagaaaaaac gcgagctcgc ggcaaaagta ttccgtcata ctgcggcata tgatgcactg 609721 atcgctgact atctgacaaa tgttgtcggt gaaaaagaac cagagcaatt cactgtgaca 609781 tttgagaaaa aacaatcgct tcgctatgga gaaaacccgc atcaggaagc aactttctat 609841 caaacagctc ttcctgtcaa aggctccatt gcgcaagcag aacagcttca cggaaaagag 609901 ctttcttaca acaacattaa agacgcggat gctgcagttc aaatcgttcg tgaattcact 609961 gaaccggctg ctgttgctgt gaagcatatg aacccgtgcg gcgtgggaac aggaaaaacg 610021 atcgcagaag cgtttgacag agcgtttgaa gcggataaaa catctatctt cggcggcatt 610081 atcgcgctga accgtgaagt ggacaaggca actgccgaag cgcttcacaa cattttctta 610141 gaaatcatca ttgcgccttc attcagccaa gaagcgctcg acgtcctgac tgcgaagaaa 610201 aatctccgtc tgctgacgct tgacgtatcc gccgctgttc aaaaggaaaa acagctgaca 610261 tccgttcaag gcgggctgct gattcaagat ttagatatgc acggcttcga tgatgctgag 610321 attagcattc cgacaaaaag agagccgaac gagcaagagt gggaagactt gaagcttgct 610381 tggaaagtcg tgaagcatgt gaaatcaaat gcgattgttc tcgcgaagga caacatgaca 610441 gtcggcgtgg gagcaggcca aatgaaccgc gtcggatcgg caaaaatcgc aatcgagcaa 610501 gcaggggaaa aagcgaaggg cagcgcgctc ggttcggatg catatttccc aatgccagat 610561 actgtcgaag aagcggcaaa agcgggcgtt acagccatca ttcagccagg cggatcgatc 610621 cgagatgagg attccatcaa aaaagcggat gaatacggca ttgccatggt attcaccggc 610681 atcagacact tcaaacatta aggggatgaa aacgacgtga atgtattaat tatcggtaaa 610741 ggcggaagag aacatacgct ggcgtggaag gcagcgcaaa gcagcctcgt cgagaatgta 610801 tttgccgctc ccggaaatga cggcatggca gcttccgctc agcttgtaaa cattgaggaa 610861 agcgaccacg cagggcttgt ctcatttgca aaacaaaatc aggtcggcct gaccattgtc 610921 ggccctgagg ttcctttaat tgaaggtctg gtggatgaat tcgaaaaagc gggcttacat 610981 gtgttcggtc cgtcaaaagc tgcggcgatc atcgaaggaa gcaaacagtt cgctaaggat 611041 ttaatgaaga aatacgacat tccgaccgca gaatacgaga cgtttacatc ctttgatgag 611101 gcgaaggcat atgtgcagga aaaaggtgct ccgattgtga taaaagcaga tggacttgca 611161 gctggaaaag gcgttactgt ggctatgaca gaggaagaag caattgcgtg cttgcatgac 611221 tttcttgaag atgaaaagtt cggtgatgcg agcgcgtccg ttgtcattga agaatatctt 611281 tctggtgaag aattttctct aatggccttt gtcaaagggg aaaaggtgta tccgatggtg 611341 attgcccagg atcacaagcg ggcgtttgac ggagacaaag gcccgaatac aggcggcatg 611401 ggcgcctact cgccagttcc gcaaatttcg gaagaaacgg tccgccatgc tgtagaaacg 611461 atcgttaagc cggctgcaaa agcaatggta caagaaggcc gttccttcac tggcgttttg 611521 tacgctggat tgatgcttac tgaaaacggc tcgaaggtca ttgaatttaa tgcccgtttc 611581 ggcgatccgg aaacacaggt cgtgcttccg cgcatggaat ctgatctggt acaggtgctt 611641 cttgatcttt tagatgataa ggaagttgac ttaagatgga aggataccgc ggcagtgagt 611701 gttgtgcttg catcagaagg gtatccggaa agctatgcaa aaggcacgcc gatcggcagc 611761 cttgcagcag aaactgagca ggtcgtggtc ttccatgccg gaacgaaagc agaaggtgga 611821 gagttcgtta caaacggggg gcgcgtcgcc aatgtgacgg cttttgatga aacgtttgaa 611881 gcggctagag accgagtgta caaagcggtt gatgaaattt tcaaaccggg actctttttc 611941 agaaaagaca ttggggcacg cgctttaaag gctgcccaaa aataagtgag gaaaacccgc 612001 agaatagctg cgggtttttt gttatcaaaa agcgggatgg cagctagaag aagaaagcac 612061 aacgagcgtg gttggttttc catgggccat cgaggtgtca ataaaatcct caagcgtatg 612121 taccgattca gtcacgacct ttgtcacata gctgtacatc cccgtgatgc ggtggttttc 612181 tgctacatca ggatgcgatg ttgcaaaggc ggcgtagtgc ttgcagcttt tcggctccat 612241 gagaataaaa gcggtgacat gcttgtttag tttttcgtaa cagatattcg cgctgtagcc 612301 ggtaatcact cctttgtctt ccagcttcct gacacgctcc gccgcgcttg gcgagctgag 612361 tccgacaagc tttcccagct caaccatcgt taatctgccg tttcgctgca aatgcgagag 612421 aatctgaagg tctgtatcgt ccatttgtct ggctccttta catatttagg cgaatgaatg 612481 aaaattcctt tgatcgtaag gtaatgctgt tgatttaact tcattgtagc atatggatgc 612541 cgtcttattt tttctataat aaagccatca atcagagagg gggcatcatg ttgccagaat 612601 tgcagcgctc tattacttgg atacaaggga cggcgttaac gattggggcg gttttaggat 612661 gcgggatatt aatcctgccg tctgtcaccg cggacacggc cggccccgct tctttatttg 612721 tttgggtgtt catgtccttc ttatcctttt ttcttgtcgg cacgctggcc cggcttgtga 612781 aaatagcgcc tagcgcggga ggaatcacgg cttatgtgca gctggccttt cagaaaaaag 612841 ccggggctat tttgggctgg atcatgttag ggtccgttcc gatcggcgtt cccatcatcg 612901 ctttgactgg cgcgcattac gtcagttaca tcacagaggc ggccgattgg cagattacat 612961 tgattgctgg ttgcatgctg gctatatcta ttttgcttca tatgagaggg attcaactat 613021 cagcaaacat tagtacactc gttatatgtg tcatcgtatt tctgcttgtc acttctattg 613081 ctgtgtcatt gccacacgtc acgatagcag aattcaagcc gtttcttccg catggctggt 613141 ctgccgctgg atctgtttct gttatgattt ttttctcttt tgtaggctgg gaaatgatta 613201 ccccgttggc tgaggaattt catcgtcctg aaaaagatgt cccgctcagc ttgtttttgg 613261 cagcgtcttg tgtggcgggg ctgtatatca tgctgtcatt tgtgaccgtg ggtactcatt 613321 catatggaga gaatggagaa attgcatcgc ttgccatgct catttcaaaa ggagcaggag 613381 aaagcggtgt atatgtcacg gtatgtttag cgctgtttat tacattcgcc accatccatg 613441 ccaatattgc cggtttttca agaatggtgt acgcattggc gagagagggg cacatacccg 613501 tattttttgg aaaactcagt gcgacaaaac gtacgcctat tcgcgttttg acagcgatgg 613561 ccgcagtgtt tggcttagtg cttgcagcgc atggtctgtt tcaaatcgat ttgacgactc 613621 tgttgaaagg gccgagcgcg gcttttatcg catcttacat atgtacaatg gcggcagcac 613681 tgaaactgct gggcaggaga gatataggct ggtggatggc gctcggggca tttgtggcgt 613741 gcgcggtgat ttattcattc agcggctggg cactgcttta tccggcagtg ctggcagctg 613801 caggatattt ctatatgaaa acaaagggtg ggcataaaaa aaagcttgat cacgttttgt 613861 gatcaagctt ttccatttat ccgttttgat gctcgttatt tccagaatcg ctgtgttgaa 613921 acatgtaggt cacaggacag aagcgcaaga ttcccgaacc cgctttcatg gcccccataa 613981 agatgtaaaa gagatgcatt ctgcaccaag gttttttcgt aaactttgca ctggcggctg 614041 acataatcgt caatccgcag gcgattctga acacggcatt gatgagactg atgtttggct 614101 tcaaggaaat ccgctccttt tacttaaaaa agttttttaa tcgaaccttc aaaaatttgt 614161 aacgttttta tcgtgcgtga tgaggaagga tgtgatacca tgagtctaat acatgtaaag 614221 gagagtatgt gaatgtccga acgcaccttt aactggaaaa acaaagacat cagggcacag 614281 gttgatgttg tagactcaaa gctgcttcca acgctccttt tacggaatgc tctcgtctta 614341 aatccatatg taaaacaatg gctgaaaaaa aacatttgga tttatcagga ccgcattgtt 614401 tatgtgggtc atgaacttcc gaatagagcc gaagaaattc atacgattga ttgtgaagga 614461 aaatacattg tgccaggtta tattgaaccg cacgcacatc cttttcaaat atataatccc 614521 caaacactgg cggaatatgt gtctcaatac ggaacaacga cattcgtgaa tgataactta 614581 tttttgcttt tgcaaagcgg aaaaaagaaa gcgcttacga ttttgaatga actcaaaaag 614641 cagcctgtcc agtatttttg gtggtcacgc tatgacctcc agaccgaggt tctgaacgag 614701 gaccacgtcc ttccatttga cgtcagaaaa cagtggattg aacatccgga tgtgattcaa 614761 ggcggagaaa tgaccggatg gcctcgcctg gtagatggtg atgatttaat gctccactgt 614821 atgcaagcta caaagaaaca gagaaaacgt attgaagggc attttcccgg cgcttctgat 614881 aaaacgctta caaaaatgaa gctgttcggt gcggattgtg atcatgaagc gatgacaggt 614941 gatgaagtga tgagaaggct ggaactgggc tattatgttt cccttcggaa ctcttccatt 615001 cgccccgatg taagaaaaat cttgcaagag ctgcatgaga agggcttccg ctattatgac 615061 cacttctttt acacgacaga tggcgcaacc ccgaatttct ataaaggcgg catgacaaac 615121 gagctgattc gcattgcgtt agaagaaggc gtacctgcaa tcgacgccta caatatggca 615181 tcatttaata tcgcaaagta ttaccaaatg gatgattatt taggagttgt cggaccgggc 615241 agactggcat cgctaaacat actggaagat ccgttaaatc cgaatccagt gactgttctg 615301 tcaaaaggga ccattctgcg tgaaaacggc tgtgatttga aggcgtttac aaagacggac 615361 tggcacaaag gcggtcttgt cccgcttgag ctttcatatg atatgacgat ggatgacttg 615421 cagttttcta tgccgatggg cgtgaaaatg cggaatgcgg ttattatgga gccatatatg 615481 attgagatcg acaattcgat ggaacagctc tcgtttgacc atgatgaaag ttatttgacg 615541 atgctcgaca gacacgggaa atggcgcgtc aatacgatga taaaagggtt tgcctcaagc 615601 gtgcagggat ttgtaagctc ctttacgacg acgggcgaca ttgtcgcgat tggaaaaaat 615661 aaagcggata tgctgctcgc tttcgcccgc atgaaagaaa tcggaggagg aattgtttta 615721 gcggagaacg gaaacattct gcatgaaatc ccgcttgcgc tgtgcggctg cgcctcttcg 615781 gaagcgtatg aagacgtgct tgagaaggaa caaaagctga gagatctttt gactgaaaga 615841 ggctatgagt tttgcgatcc tatctatacg ctgctctttt tgcaaagtac gcaccttccg 615901 tatatacgca ttacgccaag aggaatattc gacgtcatga aaaaaactgt actctttcca 615961 tcgataatgc gttaaaatat aaaagagcag ggagccgaca tatgaaaaaa tggatgacag 616021 tttgcgcgct gtgtttcgtg ttttttctgc tggtatcctg ccagcagaag gatgctgtcc 616081 cggatactgc aaagaagctg aaagctcctt taacggggct aaagactgaa cagaaagtga 616141 ctgaacgccg ccctgttgct gttgtggtga acaatcaccc gaaggcgagg ccgcagtcgg 616201 gtctgtctaa agccgacatt gtcatagaag cgctagccga agggcaaatc acaagatttc 616261 tggccatttt ccaaagccag atgcctgaaa ctgtcggacc tgtgcggagc gcgcgggaat 616321 atttcgtcac tctcagcaat ggctttgaca gcatatttgt ccatcacggc tggagtcccg 616381 gcgccaaaaa gcagctggaa tccggagctg ccgattatat gaacggattg gattttgacg 616441 gaagcttatt ttggagagct gatttcagca aaccgcccca caattcctat acgtcttatg 616501 attacataaa aaaggcggca gaacaaaagg gttataagct gaagcaggaa acaaatccgc 616561 tgctgtttca aacatcagat gcaaaacctg caaatgaatc ttacaatgtt cgggtagatt 616621 atggaacaaa taacgttaca aatcttgtcg aatacaacta tgataaaaaa gctgaatttt 616681 atacaagaag ctctgatggt gtcataacga cagaccggga aaccggaaag ccggttgcaa 616741 tgcaaaatat tttcattgtt gaagccagcc atcatattat tgatcaagat ggaaggcggg 616801 acatcgactt ggaatcagga ggaaaaggtc tgttgtttca gcacggaaac gtcattgaaa 616861 cagactggaa acaagtgaat ggcagaattg tgccggtaaa agacggcaag tggcttccgt 616921 ttgtgccagg aaagacttgg atcaatatcg tacctgatct tgatgcggct tccattagta 616981 aaggagaagg tgtgtaacga tgcaaatcga taaattacgc ggcaaagagc tggaccagtt 617041 atttaactcg atcttatcgc tgaaagacct ggaggaatgt taccgattct tcgatgatct 617101 atgcacaatt aacgaaattc aatcgctggc tcagcgcctt gaagtggcgc gcatgcttcg 617161 cgaaggaaac acgtatcata agattgaaac agaaacaggc gcttccacgg ctacgatttc 617221 ccgtgtgaaa cgctgcttaa attacggaaa tgacgcttat gaaatggcgc ttgaccgtgt 617281 gaaggagacg gaaacagagt cttcttccaa ataaaaaacc gccctgccgt ctggcaaggg 617341 cggtttcttt atgaaacaaa ttgatggatc aggttgtcga tattgatgat actgccatcc 617401 tctttccgat agacaacatg ctccttggaa aaatgaatcg gcgaattaat ccctgctgcg 617461 gctgcaaggt taaatagtcc ctcgcgcaat gaaataacgt agttgcagac acgatgctgt 617521 ttttcctcaa cgctcagtgc tttttgcaat ttcggatctg tcgtcgccac acctgccgga 617581 caggtgttgg tgtggcagac gagagcgcgg atgcagccaa cggaaaacat catgccgcgt 617641 gcgatgttaa caaagtcagc gccgagggct aaggcgaccg cgattttatc aggagtcagg 617701 agctttccgg aagcaaagat tttcagctgg ctgcgcaagc cgtactgttt aagaagcgtg 617761 tccacaatag gcagcgctgt cataatcgga aggccgactg tatccgcgag ctcgtaaaag 617821 gaagctccgg taccgccttc acttccgtcg atcgtgataa aatccggatg ctttccgctt 617881 ttctgcatat gagagaaaag ctcatgcaat tcttcaggat gccctgcgac cagtttgatg 617941 ccgactggct tttgtccgac atctctaagt ttttcaataa agtcgagcat ttcaggaggg 618001 tttgagaatt cataaaagcg gttcgggctg tcaatcgact ttccaggttc gacattccga 618061 atgtctgcca cttcctctga tactttggcg ccgtccacat ggccgccgcg ggttttcgct 618121 ccttgtgcca gctttagctc aaacgcttta atctggtcaa tcctgctttt tcttttaaat 618181 tcctcccacg aaaattcccc gtttcttttg cgcacgccga ataggcccgg tccgatttgg 618241 caaatgatat cggcgccgcc ctttaagtga tattcagaca atcccccttc acctgtattc 618301 atccaggtgc cgcctgccag atggagccct tttgagagcg ccgtaacagc ccgttctcca 618361 agagaaccgt agctcatggc agactggccg actaagccct tcacataaaa tggcttctcg 618421 catgtatgct cgccaatcac ctgtacatca tcaggatgga gaaaatacgg gtctgccttg 618481 atatgttcgg catgctcctt gcgtttgaac agattgtcag catccatttt atagatttgg 618541 gtttcaattt ttggcgtttg atttacatgc atttcttccc tttgttttgg aaacatagcg 618601 ttacggatat aatagccagg tttatcaaaa tctcttacag atccaaagcc catcattctg 618661 cttttgtatt tgccggagat gacggtttgc tcatattcct ttcgtgaaaa tggctgctct 618721 tcattgtcat tgctgtataa atactgtctg agctccggcc cgattttttc aaggatatac 618781 cgaaaccttc cgatgacggg atagttgcga agaattgagt gctcctgctg tttttcatcc 618841 tttatgtaga tccaggcaaa caagacgatc gggatagcga tgatcccaat gataaatgcg 618901 atgagtgcta ttatgatggt ttccatctct cagcctccct ttttatgtaa ccatttccac 618961 agtagaacac tttccaaaca atagcagaag gaatctggtg aaaaatgtgt gctcctgccg 619021 atacaggact caccatgcag gtactgccat atgctctctt tttttatgaa aaaagaatca 619081 aaacaccttt ttcagtgaat aacgagatta acggcttttt ccgtttttcc gcgctatgtg 619141 aatttgttat aatgtttaaa tggtaacaaa cgaatggagg aacgtatgac gtgtacgatg 619201 taacggagtg gaagcatgtc tttaaactcg atccaaataa agatttgcct gacgaacagc 619261 tggagattct ttgcgaatca ggaacggatg cggtcattat cggaggaagc gatggtgtga 619321 cagaggataa tgtcctgcgg atgatgtcta aggtaagacg gtttttggtg ccgtgtgtcc 619381 tagaggtatc agcgattgaa gcgattgttc ccggctttga cttatatttt attccgagtg 619441 tattaaacag caaaaacgcg gattggattg tcggaatgca ccagaaagcc atgaaggaat 619501 acggagaact gatgtctatg gaagaaatcg tggcggaggg ctactgcatc gcaaatccag 619561 attgcaaagc cgcggcactg actgaagcgg acgccgatct gaatatggat gatattgtcg 619621 cctatgcgcg tgtgtcggag ctgctgcaac tgccgatttt ttatttagaa tacagcggcg 619681 tgcttggaga catagaagct gtcaagaaaa cgaaggctgt attggaaacg tccaccttgt 619741 tttacggcgg cggcatcaag gatgcggaaa cggccaagca gtacgcagag catgcggacg 619801 tgatcgttgt aggcaatgcg gtgtatgaag attttgacag ggctttgaaa acagtagcgg 619861 ctgtgaaagg cgagtagtaa attgtacgga tttggtttat gatagaacgt atgttttgta 619921 taggcgggtg aacaaatttt gaattatatt agcaatcaat tactaagcgg tttaaacccc 619981 gttcagcagg aagcagtcaa aacaacggac gggcctcttt tgctgatggc gggagcgggt 620041 agcggaaaga cgcgtgtcct gacccataga attgcttatt taatggcaga aaagcatgtg 620101 gcgccgtgga acattctggc gatcacattt acaaataaag cggcacgcga aatgaaagaa 620161 cgtgtggaaa gcatcctcgg acccggcgcg gacgatatct ggatctccac attccacagc 620221 atgtgcgtgc ggatcttgcg cagagatatc gaccggattg ggatcaaccg aaatttctcc 620281 atccttgata cggctgacca gctttcagtg atcaagggga ttttgaagga gcgcaatctt 620341 gatccgaaga agtttgaccc gagaagcatc ctcggcacga tcagcagtgc aaaaaacgaa 620401 ttgaccgaac cggaggaatt ctctaaagtt gctggcggct actacgatca ggtggtcagc 620461 gatgtatatg ctgattatca gaagaagcta ttgaaaaacc agtcgctcga tttcgacgat 620521 ttaattatga cgacgattaa actgtttgac agagtgcctg aagtgcttga attttatcag 620581 cgcaaattcc agtacatcca cgttgatgag tatcaggata cgaacagggc acaatacatg 620641 ctcgttaagc agcttgccga gcgtttccag aacctttgcg ttgtggggga ttctgatcag 620701 tcaatctaca gatggcgcgg cgcggatatc accaacattc tttcatttga aaaagattat 620761 ccgaatgcaa gcgtgatttt gctagaacaa aactatcgtt caacgaaacg gattttgcgc 620821 gcggctaacg aggtcattaa aaacaactct aaccgcaaac cgaaaaattt gtggacggaa 620881 aatgatgaag gcatcaagat ttcctattat cgcggtgata atgagttcgg tgaaggacag 620941 tttgtggccg gcaaaattca tcagcttcac agcacaggca agcggaagct gtcggatatc 621001 gccatattat accggacaaa cgcgcagtcc cgtgtgattg aggaaacgct tctcaaagcg 621061 ggcttgaact ataacattgt cggcggcaca aagttctatg acagaaaaga aattaaagac 621121 attcttgcgt acctgcgcct cgtatccaat ccggatgacg atatcagttt cacgcgcatt 621181 gtcaatgtgc cgaagcgcgg agtcggcgcg acatcacttg aaaaaatcgc ttcgtatgcg 621241 gccataaacg gcttgtcctt tttccaagcg attcagcagg ttgattttat cggcgtcagt 621301 gccaaagcgg caaacgcgct tgacagcttt agacagatga ttgaaaacct gaccaatatg 621361 caggattact tatccattac agagctgaca gaagaaattc ttgataagac ggaatacaga 621421 gaaatgctga aggctgagaa atcgatcgaa gcccaaagcc gtttagaaaa tatcgacgag 621481 ttcctgtctg ttacgaaaaa ctttgaacag aaaagtgaag acaagacact cgttgcgttc 621541 ctgacagact tggcattgat cgcagatatt gatcagctcg atcagaagga ggaagagtca 621601 ggcggcaagg atgcgatcac cctgatgaca ctgcacgccg cgaaaggact ggagtttccg 621661 gttgttttct tgatggggct tgaagaaggc gtcttcccgc atagccgttc actcatggag 621721 gaagcggaaa tggaagaaga acgccgcctt gcgtacgttg ggattacaag ggcggaacag 621781 gagctttatc tgaccaatgc taaaatgcgc accttgtttg gccggacaaa tatgaacccg 621841 gaatctcgct tcattgctga aataccggat gatttattgg aaaacctaaa tgagaaaaaa 621901 gaaacaagag cgacgtctgc gagaaaaatg cagccgagac gcggccctgt ttcacgcccg 621961 gtatcctacg ccagcaaaac aggcggcgac accttgaact gggcagtcgg agataaggcg 622021 ggccataaaa aatggggaac aggaactgtc gtcagcgtga aaggcgaagg agaagggaca 622081 gagcttgata ttgccttccc gagccctgtc ggcgtgaaac gcctgttagc agcatttgct 622141 cctattgaaa agcagtaatt gaagaggaaa ggaagaagca gatggacaaa gaaacagcga 622201 agcagcgggc agaagaactg cgccgcacca tcaacaagta tagctatgaa tattacacct 622261 tagatgaacc gagcgtccca gatgccgaat acgacagatt gatgcaggag ctgatcgcga 622321 tcgaggagga gcacccagac ctcagaacgc ctgactctcc tacgcagcgc gtcggcggag 622381 ccgtgcttga agcgtttcag aaagtcaccc acggcacacc gatgctcagt ctgggcaacg 622441 cctttaatgc tgatgatctt cgtgatttcg accgccgtgt gcgccagtcc gtcggcgacg 622501 atgtggcgta taatgtggag ctgaaaatag acggtcttgc tgtttctctc cgttatgaag 622561 acggctattt tgtcagaggg gccacaagag gtgacgggac gacgggagag gatatcacgg 622621 agaatctgaa gacgatccgc aatatccccc ttaaaatgaa ccgtgagctg tcgatcgaag 622681 tgcgcggcga ggcgtatatg ccgaagcgtt cgtttgaagc actcaatgag gaacggatta 622741 aaaatgagga agaaccgttc gccaatccgc gaaatgccgc ggcgggatct ctcagacagc 622801 tcgatccgaa aattgcagcg aaacgaaacc tcgatatctt cgtctacagt atagcggagc 622861 ttgacgagat gggtgtagag acgcaaagcc aagggcttga ttttctcgac gaactcggat 622921 ttaaaacgaa tcaggaacga aaaaaatgcg gcagcataga agaagtcatt acgctgatcg 622981 atgagcttca ggcgaagcgc gcggacctgc cgtacgaaat agacggcatt gtcattaaag 623041 tcgattctct cgatcaacag gaggagctcg gttttacggc gaaaagcccg cgctgggcca 623101 tcgcgtataa gtttcctgct gaagaggtcg tgacgaagct tctcgatatc gaattaaatg 623161 tcggcagaac gggtgtgatt acgccgactg cgattcttga gccggtaaaa gttgccggca 623221 caacggtctc aagagcatcc cttcataacg aagatttaat taaagagaag gacattcgga 623281 ttttggataa ggttgtcgtc aaaaaagcgg gcgatatcat cccggaagtt gtgaatgtcc 623341 tcgttgacca gcgcacagga gaagaaaagg aattcagcat gccgacggaa tgtcctgaat 623401 gcggcagtga actcgtccgg atcgaaggag aagtggcgct tcgctgcatt aaccctgaat 623461 gtccggcgca aatccgggaa gggcttatcc atttcgtttc ccggaatgcc atgaacattg 623521 atgggctcgg cgaacgagtg atcacacagc tgtttgagga aaaccttgtc cgcaatgtgg 623581 cagatttata taagctgacg aaggaacgag tcatccagct cgagcgcatg ggcgaaaagt 623641 ccactgaaaa cctgatcagc tccatccaaa aatcaaaaga aaattcgtta gagcgcctgc 623701 tgtttgggct tggcatccgt tttatcggat caaaggccgc aaagacgctt gccatgcatt 623761 ttgaaagctt ggagaacctg aaaaaagcct ctaaagagga acttctcgcg gtagatgaaa 623821 tcggtgaaaa aatggctgat gctgtgatca cctattttca taaagaagaa atgcttgaac 623881 tcttgaatga acttcaggag ctgggcgtaa acacgctcta caaaggcccg aaaaaagtaa 623941 aagcagagga cagcgactct tactttgctg gtaaaacaat tgttctgaca ggaaagctgg 624001 aagagctgtc aagaaacgaa gccaaagcgc aaatcgaagc gctgggcgga aagctgactg 624061 gaagcgtcag caaaaacaca gacttagtca tcgccggaga agcggcggga agcaagctga 624121 caaaagcaca agagctgaac attgaagtgt ggaatgaaga acagttaatg ggagagctaa 624181 agaaataaga ggagtgtttt ctattgaaaa agacgttggc attggcggca acggcggcag 624241 tattaatgct gtctgcctgc tcgtcaggtt tcggggggga gaaggaggaa gagattacgc 624301 aaaagacggc gaaatcgtca gaaaaagcga ttgtcccgaa atataatatc tctgactcct 624361 attacaaaat ggtgctgccg tttaaggcag gcaaagcgcg cggcttaaca acggaacagc 624421 tgaatacaag gctggacatt gacgaatttg aaacagggct gatgcgcctt gcccaagatt 624481 ctttctcaac tgacgattat ctgttccaag aaggacaata tttagatgag gatacagtat 624541 taagctggct ggcacggaaa aaaacgggct ctgatttgaa aaaagccgaa aaagaagata 624601 agaacttcaa aaatgaaggc ttgaacccgg cgctcccgag ttctggttca acagaagaaa 624661 agaacgaaag cagcccaatt tatttagcat ccatgcttga gcacgattat ttagtcagaa 624721 aagacaagaa ttctatccag cttggcggcg tcatgatcgg actggcgtta aactcagtgt 624781 attactatcg tgaaaaaact ggcgacccgc aaaaagaagt ggagattaaa gacagcacgc 624841 ttcgccagca gggagaaaaa attgcacagg aggttattaa ccgcctccgc aaaaaagata 624901 acttgaagaa tgtgccgatt accgtggcgc tctacaagca ggcgtcaaaa acatcgattg 624961 tgccggggaa cttcatcgcc aaaacagagg tcaaagcagg ctctactgat atctcaaatt 625021 gggatgacat caatgaaaaa tatgtattct atccggcgga tacaaccaca gcagaaaagt 625081 acccggatga caccgaggtc tttaagcggt tcaaaaactc aattgaagaa tatttcccga 625141 actatacagg cgttgtcggt acagcgctgt atgaaaatga tgaaatgaag aaaatgaaga 625201 ttgacatacc aatgcaattc tacggaaaaa gtgaagttgt cgcgtttacc cagttcttaa 625261 cgggtgaagt gatggactac tactctaaga gctcagttga tgtcgaagtc aatatcacgt 625321 cctcagacgg acaggaagcg gtcattatcc gcaatgccgg agataaagag ccgactgttc 625381 acatttatga ctgatagaaa acccttgtgc catattggca caagggtttt tatgttacaa 625441 ttaacaggaa aagggaaaat attttcactt ctgccgaaac acaaatcaag gggaggtatg 625501 ttgatgctgg aaatcgtgtg aaaacaatca ttatcaaatc tatagcaatg aaaggatgtt 625561 agacgtgcat aaagatatca aaaaaatatt tcatgaagag caggttttgg cagaagctgc 625621 agcgagatac ggtttctcaa aagatcaggt gcgttttctg gctgatgcgg aaaactatgt 625681 atatgaatgt atgaaagaca atcaacctta tattttaaag attacccata cgattcggag 625741 atcttctgat tatatgatgg gagagatgga atggctccgt caccttgcaa tagggggaat 625801 ttcagtagcc aaaccgctcc cgtcgctgaa cggaaaagac gtagaagcag tgccggacgg 625861 aaacggcggg tcatttttat tgagagtgta tgagaaagcg ccggggcaaa aagtggatga 625921 atcggactgg aatgaaacgc tattttatga gcttggcaga tacacaggca gcatgcacag 625981 cctgacaaaa agctacaaat tgagcaatcc cgctttcaaa agacaggaat gggatgaaga 626041 ggagcaatta aagctgagaa aatatgtgcc tgaagatcag ataaaggtgt ttcagcaagc 626101 cgattctttg atgaatgaac tgcggaggct cccgaaaagc caggacaact acggcttggt 626161 gcatgcggat ctgcaccatg gcaattttaa ctgggatcat ggcaaaatca cggcatttga 626221 ttttgatgat atcggctaca actggtttgt taacgatatt agcattcttc tctacaatgt 626281 cctgtggtat cctgttgtgc catatgatga taaagctgcg tttacagaag aatttatgac 626341 gcattttatg aaagggtact gggaggaaaa tgagcttgac cctgcatggc tgatgataat 626401 acctgatttc ctccgccttc gccatatgct gatttacgga ttgctgcatc agatgtttga 626461 ccttaacaca ataggagaag aggaaaaaga aatgctggcc ggtttcagaa gagatataga 626521 gaatggcacg ccgattacag catttgattt ttcagcactg gtgtagatag aaaaagccaa 626581 tgggattcca gtcccattgg cttttataat gtatcacact tcacgccgac tacgccttca 626641 atggctttaa tgtcatagta gacatcggtc gtgtatctgt ttttatggac gcggaccttc 626701 acttccataa ttggaaaatc cttttcgcct aggtcgtcga tccgaacgga gtgtgctttg 626761 atatctcttc ttttcatttc ttttaaaatc tctgtcattt tgtctttatc agaaagtgac 626821 attctgatgc ggatgtcttt ttcctgcagg cggtcggggc cgatttttct gaccacccat 626881 gggagaaatt ccacactgat caggatgaac agaagactgg caaacgcttc tttataaaaa 626941 ccggctcccg tagcaagccc gagccccgct gccccccaga tcatggccga tgtcgtcagg 627001 ccggaaatga catcattgct ttttcgcagg atgacaccgg cgccgataaa cccgacgccg 627061 gagatgattt gtgccggcag acgaagcgga tccatcatga tgcggtagta tttagggaaa 627121 tgatatgccg cattaatact gacgatcgtc agcatgcatg agctgactgc gatgacaata 627181 caggttttta atccgagcgg cttatttttt aattcgcgtt caagcccgat gaccatgcca 627241 atcaatgtgg caatgcccaa tttcaataaa atatcaggat caatatacca gctcaacagc 627301 aaacttcccc cttctctatg gtgtttttaa ataaatatga ttttctcaca gtatttatag 627361 caaaacaaga gcacaaaagc caccaagctg cgcttgatgg cttattgctt actttttgcg 627421 ttttaacagc ttttccatga caccgaataa tcggtaagag gcttttgcag gacgttttgt 627481 gatcatgctg acaatgatgc cggcaatcat actgagaata aacccaggga tgatttcgta 627541 cacaccggtt gattttgcca ggccggttgt aatccagatc aacacggtcg cagccccgac 627601 aatcatggca gcaagcgcgc cccattcgtt cattcgtttc caatacagac tgagcagaat 627661 cgcaggcccg aaagctgaac cgaagccggc ccaagcgtat ccgaccaaat caagaatggt 627721 gctgttcggg ttcaatgaca agagtaccgc gataacggca atgactaaga cggacaatcg 627781 cccgatcatg accaattctt tatcagaagc ttttcgtctg aaaaatgacc ggtataaatc 627841 ctctgttaca gcacttgctg tgaccaagag ctgtgaggaa atcgaactca tgatggcagc 627901 caaaatagct gacaataaga accctgtaat taatgggtgg aacaagattt tagagaagat 627961 aatgaaaatc atctccggat cttttacagc aactccgaat ttatgggcgt atgcaacacc 628021 gattaaaccc gtcagcacgg aacctagaac tgtaatgatc atccagctca tgccgattcg 628081 gcgtgcaggt tttaaatctt taatgtcttt aatggccata aatcggacga tgatatgagg 628141 ctggccgtag tagcccaacc cccaggctaa ataggaaata atgctaatga cgctcgcgcc 628201 tttaaaaata tccaataaat gtggattaac agcgtcgatt tcatggaaag tcggagcaac 628261 gccgcccaca tgggtaaaag caacgatcgg cacaagcact agtgctgcaa acatgatcgc 628321 accctgcacg aagtcagtca gactgacagc aaggaaaccg ccaaacagtg tgtataacac 628381 gacaactgcg gtggtcagaa acaggcctaa tttgtaatcc gcaccaaaag cagattcaaa 628441 cagccgtccg ccagatacca taccggaaga ggtatacaat gtgaaaaaga tcatgatgat 628501 caatgcagat acgattttca gcagtgatga agaatgctgg aatcgtttat caaagaaatc 628561 aggaattgta atcgcatcat ctgccgcttc tgtataagca cgcagccttg gagccagcag 628621 caagtaattt gagtacgccc cgattgtaag acctaaagca agccataagg tggacagccc 628681 tgtcgcaaac atcgcgccgg gaacacccat cagcatccat ccgctcatat cggccgcgcc 628741 ggcagacaaa gcagtaacga atggtccgag gcctcttcct ccaagcatgt aatcattgat 628801 gtcagtggtt ttcttgaatg cataccagcc gattaacagc atggcaataa agtaaattcc 628861 taaagatata ataatttcaa tactcacgtt ttaccctctc ttcatttcta ataatgttgc 628921 atcacctctc aaattgatgg tgccagttaa gcagcctggc gtaagtgcaa aacaaaagaa 628981 attcttttgc gggtgcactt ggtaacttaa cctaacaaag tattcccggc cattcaagcg 629041 atgaaacatt gatcataagc tggaaatacc gttgcaaacc tagaagggaa taaagaataa 629101 aacgctttca aaaaataatt aaagtaaaaa tattcagaaa aatatttcgt ttctccttct 629161 cctcatttta gtataaaata tatagggtat tgtttcgaaa acacaggcct gtctcaaggc 629221 gttttgttgc tttaaagggc ttgtttttga tatgatcagt attatatgac ttaacggaga 629281 aatatgtgga ggtggatcat atgtcacgaa tttcaataga agaagtaaag cacgttgcgc 629341 accttgcaag acttgcgatt actgaagaag aagcaaaaat gttcactgaa cagctcgaca 629401 gtatcatttc atttgccgag gagcttaatg aggttaacac agacaatgtg gagcctacaa 629461 ctcacgtgct gaaaatgaaa aatgtcatga gagaagatga agcgggtaaa ggtcttccgg 629521 ttgaggatgt catgaaaaat gcgcctgacc ataaagacgg ctatattcgt gtgccatcaa 629581 ttctggacta aaggagggac acaagaatgt cattatttga tcataaaatc acagaattaa 629641 aacagctcat acataaaaaa gagattaaga tttctgatct ggttgatgaa tcttataaac 629701 gcatccaagc ggttgatgat aaggtacaag cctttttggc attagatgaa gaaagagcgc 629761 gcgcatacgc gaaggagctt gatgaggcgg ttgacggccg ttctgagcac ggtcttcttt 629821 tcggtatgcc gatcggcgta aaagataata tcgtaacaaa agggctgcgc acaacatgct 629881 ccagcaaaat tctcgaaaac tttgatccga tttacgatgc tactgtcgtt cagcgccttc 629941 aagacgctga agcggtcaca atcggaaaac tgaacatgga cgaattcgcc atggggtcat 630001 ctacagaaaa ctcagcttac aagctgacga aaaacccttg gaacctggat acagttcccg 630061 gcggttcaag cggcggatct gcagctgcgg ttgctgcggg agaagttccg ttttctcttg 630121 gatctgacac aggcggctcc atccgtcagc cggcatcttt ctgcggcgtt gtcggattaa 630181 aacctacata cggacgtgta tctcgttacg gcctggtcgc atttgcgtct tcattggacc 630241 aaatcggacc gattacacgt acggttgagg ataacgcgtt tttacttcaa gcgatttccg 630301 gcgtagacaa aatggactct acgagtgcaa atgtggacgt gcctgatttt ctttcttcat 630361 taactggcga catcaaagga ctgaaaatcg ccgttccgaa agaatacctt ggtgaaggtg 630421 tcggcaaaga agcgagagaa tctgtcttgg cagcgctgaa agtccttgaa ggtctcggcg 630481 ctacatggga agaagtgtct cttccgcaca gtaaatacgc gcttgcgaca tattacctgc 630541 tgtcatcttc tgaagcgtca gcgaaccttg cacgctttga cggcatccgc tacggctacc 630601 gcacagacaa cgcggataac ctgatcgacc tttacaagca aacgcgcgct gaaggtttcg 630661 gaaatgaagt caaacgccgc atcatgctcg gaacgtttgc tttaagctca ggctactacg 630721 atgcgtacta caaaaaagcg caaaaagtgc gtacgttgat taagaaggat ttcgaggacg 630781 tatttgaaaa atatgatgtt attgttggac cgactacacc gacacctgcg tttaaaatcg 630841 gtgaaaacac gaaggatccg ctcacaatgt acgcaaacga tatcttaacg attccggtca 630901 accttgccgg cgtaccggga atcagtgtgc catgcggatt agcagacgga cttccgctcg 630961 gcctgcaaat catcggaaaa cactttgatg aaagcactgt ataccgcgtt gctcatgcat 631021 ttgaacaagc aacagaccat cataaagcaa aacctgaact gtaaggggtg aaaagaattg 631081 aactttgaaa cggtaatcgg acttgaagtc cacgttgagt taaaaacaaa atcaaaaatt 631141 ttctcaagct ctccaacgcc attcggcgcg gaggcgaata cgcagacaag cgttattgac 631201 ctcggatatc cgggcgtcct gcctgttctg aacaaagaag ccgttgaatt cgcaatgaaa 631261 gccgctatgg cgctcaactg tgagatcgca acggatacga agtttgaccg caaaaactat 631321 ttctatcctg acaacccgaa agcgtatcag atttctcaat ttgataagcc aatcggcgaa 631381 aacggctgga tcgaaattga agtcggcggc aaaacaaaac gcatcggcat cacgcgcctt 631441 catcttgaag aggatgccgg aaaactgacg catacgggcg acggctattc tcttgttgac 631501 ttcaaccgtc aaggaacgcc gcttgttgag atcgtatcag agccggacat ccgcacgccg 631561 gaagaagcgt acgcatatct tgaaaagctg aaatccatca tccaatatac aggcgtttct 631621 gactgtaaaa tggaagaagg ctcacttcgc tgtgacgcca atatctctct tcgtccgatc 631681 ggccaagagg aattcggcac aaaaacagaa ttgaaaaact tgaactcctt tgcgtttgtt 631741 caaaaaggcc ttgagcatga agaaaaacgc caggagcagg ttcttctttc cggcggcgtc 631801 atccagcaag aaactcgccg ttatgatgaa gcaacgaaga aaaccattct tatgcgtgtc 631861 aaagagggat ctgacgacta ccgttacttc ccagagccag atctagtcga gctctacatt 631921 gatgatgaat ggaaggaacg cgtaaaagca agcattcctg agcttccgga tgagcgccgc 631981 aagcgttata tcgaagagct tggcttgcct gcatatgacg caatggttct gacgctgaca 632041 aaagaaatgg ctgatttctt cgaagaaacc gttcaaaaag gcgctgaagc taaacaagcg 632101 tctaactggc tgatgggtga agtgtcagct tacctaaacg cagaacaaaa agagcttgcc 632161 gatgttgccc tgacacctga aggccttgcc ggcatgatca aattgattga aaaaggaacc 632221 atttcttcta agatcgcgaa gaaagtgttt aaagaattga ttgaaaaagg cggcgacgct 632281 gagaagattg tgaaagagaa aggccttgtt cagatttctg acgaaggcgt gcttctgaag 632341 cttgtcactg aggcgcttga caacaatcct caatcaatcg aagactttaa aaacggaaaa 632401 gaccgcgcga tcggcttcct agtcggacag attatgaaag cgtccaaagg acaagccaac 632461 ccgccgatgg tcaacaaaat tctgcttgaa gaaattaaaa aacgctaata aaaaagcagc 632521 ccttagaggc tgcttttttt atggtcaaat tgagataaag acaagatgag ggcccgaagc 632581 ctttcaactt ctttgtcgtt ggttccggcc aaattggaca gcatgccttt aataatcggc 632641 ttgcgcggtt tatcctgagt caattcttcc tcgataacat caagtgacac ggtgatatcc 632701 tcgggcagcg tgctgttttc tttcactttc tgaatgtcct caagcagctg gtcttttccc 632761 gcaggcatcg ggttaaaaat gtcttttgat acaatcggat tgagtgcaga acggctcagc 632821 ccctgtacaa gatcatccag tctctcaata ataaaggctg agatttcttc tgcatcgata 632881 ttaagctcac cgttaaatac catcacgttc atataggaat gcacaatgcc tcttgccatg 632941 atggacagat ctgcgacata ccgctcgatt ccttcgccat aggataccag caaggcgttc 633001 cggtacagct tatccgtctc catggttact ttgtaaaagt attgcttgat ttcttgattt 633061 tccggaatga tattttcggt aagcaaaaga acgataaaat ctttatgatc gcgaaaatcc 633121 tcaaattgag cgccaatttg cttttttaac acttccttag gcggctttcc ggcgagatct 633181 tcttctatat ttttcatttt gttcatagac ataccgatat aatattcaca ggcagataac 633241 agcagcgctt ctttcgattt gaagtgcaaa taaaaagcgc ccttcgaaat gccgcattca 633301 ctggcgattt cttggatcgt cgtagctgcg aatccttttt tcgcaaataa acgaatgctg 633361 gtttttatga ttctctcttt tttttcattc atgacgtgct tccccttaat ccttgaaaaa 633421 tttagtaaaa ttttctggta tatgagttga cgttgttgcg ttataacgtt tagtattata 633481 tagaatgacc agtcagtcaa taaaaaatgt aatggaggat atgatgaacc acgttattaa 633541 tttcgttctg aaaaacaaat tcgccgtatg gctgatgacg attattgtaa cggcagccgg 633601 cttgtatgcg ggtatgaata tgaagcaaga gtctattcct gacgtgaaca tgccttactt 633661 gacgatcagc acgacatatc cgggtgcaac accaagccaa gtggctgatg aagtgaccaa 633721 accggttgaa caagccgtac agaacttgga cggtgtcagc gttgtgacgt cgacgtccta 633781 tgaaaacgca tcgtcggtca tgattgaata tgattatgag aaagatatgg acaaagcgaa 633841 aacagaagca gctgaagcgt tagaaaacgt caacctgcct gatgacgcga aggatccgga 633901 gatttcacgc tacagcttga actcattccc gattctgacg ctgagcgtgt ccagtgataa 633961 agataatctg caagagctga cgaaacaagt ggaggacagc ctcgtttcta agcttgaagg 634021 catagaaggc gttgcgtccg tccaagtatc aggccagcag gtggaagagg ttgaattctc 634081 tttcaaagaa gacaaactga aggaatacgg ccttgatgaa gatacagtca agcaagtgat 634141 tcaaggttca gatgtgacaa ctccgcttgg attgtacaca ttcggaaatg aagaaaaatc 634201 tgtcgtcgtc agcggcgata ttgaaacaat taaagatttg aagaatatga gaatcccgac 634261 ggcatctgct tcaagtgcag gcagcagcgc agcatctcaa gcaggtgcgc agagtgctca 634321 agcagcccaa agcgcgcaag cggcagcaca ggtgcagcaa agcgcaagca cagcagtgcc 634381 gacggtcaag ctttctgaca ttgctacaat taaagatgtg aaaaaagctg aatccgtttc 634441 acgcacaaat ggcaaagaca gcatcggcat caacatcgtc aaagcaaacg atgcgaatac 634501 ggtagaggtt gccgacgatg tcaaagctga gctgaaaaag ttcaaagaag accataaagg 634561 cttcaattac agcgcaactc tcgacatggc ggagccgatc acacagtcag ttgacacgat 634621 gttaagcaaa gccatcttcg gtgctatttt tgcgattgtg attattctct tattcttaag 634681 agatatcaaa tcaacattaa tttctgttgt ttcaattcca ttatcattgc tgatcgcact 634741 ccttgtgctg cagcagcttg atatcacatt gaatattatg acgctcggcg caatgaccgt 634801 tgccatcgga cgtgtagtcg atgactccat cgttgtgatc gagaacattt accgccgcat 634861 gagactcaaa gatgagccgc tccgcggaaa agccttggtt cgtgaagcga cgaaggaaat 634921 gtttaaaccg atcatgtcat caacgattgt gacaatcgcg gtattcctgc cgctcgcact 634981 tgtaggcgga caaatcggtg aattgtttat tccatttgcc ttaacgattg tttttgcgct 635041 tgccgcatcc ctagtgattt caatcacgct tgtgccgatg ctcgcacaca gcctgttcaa 635101 aaaatcatta accggtgcgc cgattaaagc gaaagaacac aaacctggca gacttgcaaa 635161 catctataaa aaagtattga actgggcgct gagccacaaa tggatcacgt ctatcatcgc 635221 ggttctgatg ctccttggaa gcttgttcct cgtaccgtta atcggtgcca gctacctgcc 635281 gtccgaggaa gaaaaaacga tgcagctcac atacagccca gaaccgggtg aaacgaaaaa 635341 agaagccgaa aatgaagctg aaaaagcgga aaaaatcctg cttgaccgca agcatgtcga 635401 tacggttcag tattcattag gctctggcag cccgcttgcc ggaggagatt ctaacggtgc 635461 gttattctat atcaaatatg aaagcgacac acctgacttt gataaagaaa aagataacgt 635521 tctgaaggaa atccaaaagc aatctgaccg cggagaatgg aagtcacagg acttcagctc 635581 ttcaggcaat aataacgaat taacatacta tgtgtatggc gattctgaaa acgatattaa 635641 agacacggtc aaagacattg aaaaaatcat gaaagatgaa aaggatctga aaaacgtaaa 635701 ttcaggcctt tccagcacat atgatgagta cacatttgtc gctgaccaag aaaaactaag 635761 caagctcggt ttaaccgcgt ctcaaatttc tcaggcctta atgtcacaaa catcgcaaga 635821 accgctcacc actgtgaaaa aagacggcaa agagcttgat gtgaacatta agacagaaaa 635881 agacgagtat aagagtgtga aagatttaga gaataaaaag atcacttccg cgactggcca 635941 ggaagtcaaa atcggcgatg tggcaaaagt gaaagaagga tcaacatcag ataccgtgtc 636001 aaaacgtgac ggaaaagtct atgcagatgt cacaggtgag gttacctctg acaacgtcac 636061 agccgtatca gctgctatcc agaagaaaat cgataagctt gaccaccctg ataacgtatc 636121 gattgacaca ggcggcgtat cagcggatat cgctgattcc ttcacgaagc tcggtttagc 636181 gatgctggca gcaatagcga tcgtttacct tgtgctcgtg attaccttcg gcggagcact 636241 agcgccattt gcgattctgt tctcattgcc gttcacagtc atcggtgccc tggtcggact 636301 ttacgtatca ggtgaaacga tcagtctgaa cgccatgatc ggtatgctca tgctgatcgg 636361 tatcgttgtc acgaatgcca ttgtcttaat tgaccgcgtg attcataagg aagcggaagg 636421 cctgtctacg agagaagcgc tcctggaagc cggctctaca cgactccgtc cgatcctgat 636481 gacagccatt gcgacaatcg gcgccttgat tccattagcc ctcggcttcg aaggcggaag 636541 ccaggtcatt tcaaaaggac tcggcgtaac ggttatcggc ggtttaatca gttcaacgct 636601 tctgacgctc ctgatcgtgc caatcgtata tgaagtattg gcgaagttcc gcaagaaaaa 636661 accgggaacg gaagaagagt aaaaaacaaa aagcctcagc tctgctgagg ctttcagctt 636721 gttgaaaaac cctcgcattc gttgtcaggt ctgcgcgtcg gtgctcacga attctacatt 636781 cgctccgctc caatgctccc ccttcctaga ctacaagggt tttcaatcaa gctgaaagaa 636841 tgttaaggat gacaaaagct caaaacaaga atcagttttg agcttttgtg cgttttcacc 636901 tgtaagatta tgtacatttt gttgcgattt ttttaactca tagtataatt aaaggttgtt 636961 agtgtaaaaa tggatcggat actcttaagt aggatgatga gataatgaaa cgtgcacgca 637021 taatatacaa tccgacttca ggacgggaga tctttaaaaa gcatcttgcc caggtcctgc 637081 aaaaatttga acaagccggc tatgaaacct ccacccatgc gacgacatgc gcaggagacg 637141 ctacacacgc tgccaaggaa gcggcattgc gtgagtttga cctgatcatt gcggcaggcg 637201 gagacggaac gatcaacgag gtcgtcaacg ggcttgcgcc tttagacaat cgtccgacac 637261 tcggtgtgat tcctgtcggc acaacgaacg acttcgccag agcgctcgga atcccacgcg 637321 aggatatttt aaaagcggca gatacggtca ttaacggcgt tgcccgcccg attgatatcg 637381 gacaggtcaa cggccagtat tttatcaata tcgccggcgg aggccgtctg acggagctga 637441 cgtacgacgt gccaagcaaa ctgaaaacaa tgctcggcca gcttgcttat tatttaaaag 637501 gaatggaaat gctgccttca cttcgtccga cagaagtcga gattgaatat gacggcaagc 637561 tgtttcaagg tgaaatcatg ctgtttttgg tcacgctgac aaactccgtc ggcgggttcg 637621 aaaagctcgc gccggattcc agcctgaatg acggcatgtt tgatttgatg atactaaaga 637681 aagcaaacct tgctgaattt atcagggtcg ccacgatggc gcttcgcgga gaacacatca 637741 acgaccagca cattatttat acaaaagcga accgcgtgaa agtcaatgta tcagaaaaga 637801 tgcagctgaa cctggacggc gagtacggcg gcatgctgcc gggcgaattc gtgaatctgt 637861 accggcacat tcacgtcgtc atgccgaagg agaaagcgga acagttggat gactaaaact 637921 tggcttggta agccaagctc agaatgttga caaaatccta aaacagtttt cgttttagga 637981 ttttgtcatc ttttcagcgt gattgaaaac ctttgaagtc taggaagggc gagcatcgga 638041 gcacagcgaa tgttgaattc gtgagcaccg aagcacaggc ctgacaacga atgcgaaggt 638101 ttgcctacac gctgaaactt ggcttgaata ggccaagttt ttctttcgct taaaactaga 638161 ggtgattata gatgaaaatg aaacccccag tagaaaaaaa tgaatactac gatgtgacat 638221 ttgaggattt gacacatgaa ggagcgggcg tcgcaaaggt ccaaggcttc ccgatctttg 638281 tgccgaatgc cctacccgag gaaaaagccc aaatcaaagt gacacgcgtc aaaaaagggt 638341 tcgccttcgg ccgcctgatt gagctgaagg aagaaagccc gcatagaacg gacgccccat 638401 gcccgattta caaacaatgc ggaggctgcc agcttcagca catgacctac gaaggccagc 638461 tcctgtttaa acagaaacaa gtcaaagacg tcttagaacg catcggcaag ctggaccttt 638521 caaaagtcac cgtgcacccg acactcggca tggaagaccc gtggaactac agaaacaaag 638581 cacaggtgcc ggtaggagaa cgggaaggcg gactcgtcgc gggattctat cagcaaagaa 638641 gccatgacat catcgacatg agcgcctgcc tgatccagca atccaaaaac gacgaagccg 638701 ttcaagctgt caaagacatt tgcgcaaact acggtgtcaa agcctacaac gaagaacgcc 638761 acaaaggctg gctccgccac atcatggtca gatacggcgt tgttacgggc gaaatgatga 638821 tcgtcttcat cacaagaaca agcgacttcc cgcacaaagc gaagatcatc gaagacatca 638881 cagcgcaatt cccgcacgtc aaatccatcg tgcaaaacat caacccaaac aaaacaaacg 638941 tcatttttgg caacgaaaca aacgtcatct ggggcgaaga atacatctac gacctcatcg 639001 gagacgtcaa attcgccatc tccgccagat cgttttatca ggtcaaccca gagcaaacaa 639061 aagtgctcta cgacaaagcg cttgagtacg ctgagcttca aggggaagaa accgtcatcg 639121 acgcttactg cggcatcgga acgatttctc tcttcctggc aaagcaggcg aaaaaagtgt 639181 acggtgtaga gattgtgccg gaagcaattg aggacgcgaa gcgaaacgcc gaattaaacg 639241 gcaacacaaa cgcagagttt gctgttggag aagcggaaac cgtgattcca aagtggtacg 639301 aagaaggcat tacagctgat acgctggtcg tcgacccgcc aagaaaaggc tgcgacgaag 639361 ccctcctgcg gacaattgtg gagatgaagc cgaagcgggt agtgtatgtg tcctgtaatc 639421 ctggcacgct tgcgagagat ttgcgggtgc ttgaggatgg cgggtacgtg acgcgcgaag 639481 tgcagcctgt ggatatgttt ccgcatacga atcatgtgga gtgctgtgtg ttgataaaat 639541 taaaagaata aatagtcaaa aatctatgct gatggaactg ttggttcgag ctcgcatgat 639601 cttctcagct acagcgtcga ggtgcaggaa gcagccacaa gagcgcaaat acgtgaactg 639661 gcgtcattta cagtgtgtcc gccgcatagg cgcgaattag aagaactgtc agcagagggt 639721 gtttatcagg agcaaatatt gaaaaaacga atttccatgc tggatctgct tgaaaagtat 639781 gaagcgtgtg acatgccgtt tgaacgattt ttagagcttt tacggccgtt aaaaccgaga 639841 tactattcga tttcaagctc tccaagagtg aatccgcggc aagcatcgat cacagtcggt 639901 gtcgtgcgcg gcccggcgtg gagcggccgt ggcgaataca ggggtgtggc atcaaatgat 639961 ttagctgagc gtcaagccgg tgatgatgtc gtgatgttta tccgcacacc ggaatcccgg 640021 tttcagcttc cgaaagaccc tgaaacgcca attattatgg tcgggccagg cacgggagtc 640081 gcgccatttc gcggtttcct tcaagcccgc gatgttttaa agcgggaggg caaaacgctc 640141 ggtgaggctc atctctattt tggatgcagg aacgatcggg attttattta ccgagatgag 640201 cttgagcggt ttgaaaaaga cggaatcgtc actgtccaca cagccttttc ccgaaaagag 640261 ggcatgccga aaacatatgt ccagcatctc atggctgacc aagcagatac attaatatca 640321 atccttgacc gcggtggcag gctttatgta tgcggtgatg gcagcaaaat ggccccggat 640381 gtggaggcgg cacttcaaaa agcgtatcag gctgtccatg gaaccgggga acaagaagcg 640441 caaaactggc tgagacatct gcaggatacc ggtatgtacg ctaaggatgt ctgggcaggg 640501 atatagataa agaagactgg agacatccag tctttttagt cctttcgaaa aaatggtgat 640561 cgcgctaaac attgatgcat acaataactt cagtccgccg gaagggcggg ctgtctgcaa 640621 aacctatttt tcgtttttgc tagtttatgt tattcttata ctcggtatct atttcttttt 640681 tcaaaggcac acatgacaaa agaaatcctt tttttatttc cgagaaaaaa atgtgaaacg 640741 aaatgaaggt ttctttcgtc cagtgattgg tttccaaatg gttgtaataa aaatgatatg 640801 gtgcgaaaca taaatattcc ggcttgccgc ggtgtattta ttgttgtgtg atgccttgat 640861 tttgtttgga aagaaggaat tggaaggcag gatataaaga gcaggtaaat atgaatgaag 640921 aacttaaagt gtttaagaaa gtagaggttg ccatgaagaa acttttttct tacaaactta 640981 gcttttttgt gctggctgtt atactgtttt gggcaaaaac gtatttatcc tacaagactg 641041 agtttaatct tggggtaaaa ggcacaactc aggagatcct cctgatattt aacccattct 641101 caagcgccgt cttcttttta ggactggctt tgctggcgaa agggcgtaaa tcagccatta 641161 ttatgctgat tatcgatttc ttgatgacat ttgtgttata tgcaaatatt ttattctatc 641221 gtttctttga cgatttcttg acgttcccga acattaaaca gtccggaaac gttggaaaca 641281 tgggagacgg gattttcagt atcatggccg gtcatgatat tttctatttc ttagatatta 641341 tcattttgat tgcggtattg atctggagac ctgaattaaa agaatacaaa atgaaaaaac 641401 gctttgcatc tttagtgatc ctttctggga tcgcactgtt tttcatcaac ctgcactatg 641461 cggaaaaaga ccgtccgcaa ctgctgacaa gaacgtttga ccgcaattat attgtgaaat 641521 atttaggttt atacaactac accatttatg acggtgtaca gacggctcaa acagagacgc 641581 aaagagccta tgcaagcagc gatgatttaa caagtgtcga gaattacacg acgtctcatt 641641 atgcgaaacc aaacgccgag tacttcggct ctgccaaagg caaaaatatc attaaaattc 641701 acctcgaaag cttccagtca ttcctgattg actacaagct aaacggtgaa gaggtgacgc 641761 ctttcttaaa taaacttgcg cacggcgggg aagatgtgac gtattttgat aacttcttcc 641821 atcagacagg ccagggaaaa acatctgatg ccgagctgac aatggataac tcgatcttcg 641881 gtcttcctga aggctccgcg tttgtgacga aaggcgaaaa cacctaccag tcgcttcctg 641941 cgattttaga ccagaaggaa ggctatacaa gcgccgtcct gcatggtgat tacaaatcgt 642001 tctggaaccg tgaccagatt tacaaacata tcggatatga caagttcttc gacgcaagca 642061 cgtatgatat gtcagatgaa aatgtgatta atatggggct taaggataag ccgttcttta 642121 cagaatcgat tccaaagctt gaatctctta aacagccatt ttatgcgcat ttgattacat 642181 tgacaaacca ttatccgttt aaccttgatg aaaaagacgc gtctcttaaa aaagcgacaa 642241 caggcgataa cacagttgac agctacttcc agacagcgcg ttaccttgac gaagcgcttg 642301 agcaattctt caaggagctg aaggaagccg gcctgtatga caactcagtc atcatgattt 642361 acggtgacca taacggtatt tctgaaaacc ataaccgagc gatgaaagag attcttggaa 642421 aagagatcac agattatcaa aacgcacaga accagcgtgt gccgctgatg atccgcgttc 642481 ctggcaaaaa aggcggagtg aaccatacgt atggcggcga aattgacgtc atgccgacac 642541 ttctgcactt agaaggaatt gattctcaga aatatatcaa ctttggtact gatttattct 642601 ctaaagacca cgacgatacg gtggcattca gaaacggaga cttcgtaacg ccgaagtaca 642661 catcagtcga caatatcatt tacgatacga agacaggtga aaaactgaaa gcgaatgaag 642721 aaacgaagaa tctgaaaaca agagtgaacc agcagctgag cctttcagac agtgtcctgt 642781 acaaagactt gctgaggttc cataaactaa atgatttcaa agccgttgat ccgtcagact 642841 atcattacgg caaggagaaa gaaatcaaat aagatgaaaa agagccttga gcgggcgcat 642901 tgccttcgct caaggctctt tttttggtta tacaaccaac ttgaaaaaat agattccatt 642961 tggtcaccaa ggctggcttt ctctcatatc attacagtag attttgaaac cggattgaaa 643021 tcggacaaat tatcggggaa atgccttgat agattgtgaa gatgtaccag gtttcgaact 643081 caatattcat agagatgagg ggtagagatg aaagcggtca ttctctgcgg cggaaaagga 643141 acgagaatga gtgaagtcac gaatgacatt cctaaaccgc tcgccatgat aggcggcaaa 643201 ccgattctat ggcatattat gaaaatttat cagtactacg gagtaaacga gtttattctg 643261 cttttgggct ataaaggaga aaaaatcaag gaatactttc tcgactatga atggaagcac 643321 aacagcctga cactcgacag ctctacggga gaggtacaga tgctggggca gcctgaaacg 643381 tggaaaatta cgtttttgga gactggggta gatacgctga cagccggaag aatcttgcag 643441 gcgaaagact atatcggtga tgaaacattt ctgctcacct atggagacgg gctggccaat 643501 atcaatcttt tccatctcat cagctatcat cagacaaaag gtgctgccgc gactgtcacc 643561 ggcattgaca aagtctcgca gtttggcacc ttgacagttg aggatggcat ggcgaaaaca 643621 ttttctgaga agacatcaag tgatggaatc atcaacggcg gattcttcgt tcttagtcca 643681 aaggttttcg attatttgcc gaaggacggg aacacgatgt tcgaagatga accgctgaag 643741 aaccttgcca aagatgggga gcttgctgtg taccgccatt acggattttg gacggccatc 643801 gatacgtata aaaatctctt agaagtcaac aaaatgtgga atcaaggaca acaagtatgg 643861 aaggtatggt gaattgattt gagtttctgg aaaaataaaa acgtatttgt cacgggatgc 643921 acaggtcttt taggaagcta tttggtgaaa gagctgatcg aacagggcgc aaacgttacg 643981 gggctagtca gggatcatgt gcctcaatcc aatctttatc agggagaaca tatcaagaaa 644041 atgaacatcg tgcggggctc tcttgaggac ttggctgtga ttgaacgcgc gcttggcgag 644101 tatgagatcg acacagtctt tcatcttgct gcacaagcga ttgtcggcgt ggcaaaccgc 644161 aacccgattt ctacctttga agcgaatatc ctcggcacct ggaatattct cgaagcctgc 644221 cgcaagcatc cgttaattaa gcgggtcatt gtcgcttcaa gtgataaagc ttacggcgat 644281 caagaaaacc ttccatacga tgaaaacatg ccgctgcaag gcaagcaccc gtacgacgtc 644341 tcaaaaagct gcgcagatct gatcagccac acctattttc acacgtacgg gcttccggtc 644401 tgcattacgc gctgcggaaa cttatacggc ggcggagatt tgaacttcaa ccgcatcatt 644461 cctcagacga ttcagcttgt gctgaacggg gaagcgccgg aaatccgaag cgacggcaca 644521 tttgtacggg actacttcta tattgaagac gccgttcagg cttatctgct tcttgcagaa 644581 aaaatggaag aaaacaatct tgccggagag gcctttaact tcagcaatga gatccagctg 644641 accgtacttg aactggtaga gaaaatatta aagaaaatga acagtaatct gaaacctaag 644701 gtgctgaatc agggaagcaa tgaaatcaaa catcaatatt tatccgcgga aaaagcaaga 644761 aagctgctga attggacacc ggcctacact attgatgagg gacttgaaaa aacgattgag 644821 tggtatacgg aattcttcaa aaagtaatgt gaaacgaggt gaacaagact gtgaccagcg 644881 cgtattgcac cgttttatca aaaggaagat tatatcaggc agtcgctttg tttaagtcgt 644941 tagagcaagt tgatcaagac agtcccattt ttatactttg catggatgaa gatacgcacc 645001 gcgtgttaca gaagctgaag atgaagcagc tgaaccttgt gccggtggcc gctcttgaaa 645061 atgaattgct gctgaagctg aaggaaacta gagatcaaag tgagtattgc tggacgatga 645121 agccgatctt tctgcaagct gtgctgaaca gcaatcctga gctggagcgt gtgacgtata 645181 ttgacgggga tctctttttc tatgcagatc catcgccgat ttttgaaaac cagccggact 645241 gctcggtgtt gctttcacga ggggatattg taatcccttc ttttgagaaa gagcagattg 645301 acatgctgca gcgtctttta ggcagatata attccgggtt tatcagcttc aagcatgatg 645361 atgcaggcac ggattgcttg gagtggtgga aggaacgctg tcttgaggaa tgcaaaaatg 645421 caccgggtga agggaaattc ggtgatcagg gctatttgga ttatatgtct gagctgtttc 645481 cgaatgtgtg tgacattaca acacccggcg tgaacatcgg ccattggaat tatggacagc 645541 atacgttttc ctggaaagat ggccggatcg tgctggagga tggcagtccg ctgatctttt 645601 atcatttcag cggataccga atcgtcagca tcaatgaaat caaacagatt catgaaacaa 645661 cccgcacaga tctgccgttt gtgcatgaac tgtatcaaga gacactgccg catatcattc 645721 agcacatgca aacgttagac cctgaattta acggttttgc ttcaaaagat gacaacaaat 645781 aaatgagtaa atacaggaag tgaaaatgaa gtgaaagcaa gcgttattat tcctgcatat 645841 aattcgaagg agcgtcttta caacagcctt ctgtcattaa accagcagga gtgcgatgaa 645901 gaatttgaag tcattgtagc ggacaatggc tctgaggacg ggacgctctc gatgcttgag 645961 tcatttcaag ctgattttcc gctgatcttt acacggatta aagaaaacag gggcattgcg 646021 tacggacgaa atcaggcgct tcgcaatgcc agaggagaca tcctgatttt ccatgacagc 646081 gatatgcttg cggcaaagga ccttgtggca aaacatatta aagcccatga gaacgaagag 646141 aatctcgtcg tgtgcgggtt gttttggaaa cggatctaca gtttttacta tgaacgattt 646201 gaagaagaac ataaggaaca gctcgcaaag ctcacaggtg aaatgccgaa gaaagacaaa 646261 caaaagctgc tggaggaagc ggacatcaaa aacggaagct ttcttgataa aagctttgac 646321 ctcgataccg actttataga cgtgctcaag aagattttag atgagtacgg cgatgacttg 646381 aaaggctatc atatgccatg gcgctttttt atcacgaata attcctctgt gaaacgcaag 646441 catgtggttg acctcggttt atttgacgaa ggcattgtgc ggtacgggtt tgaggattat 646501 gacctcggga tcaggcttca tcaggccgga ttgaccttca ggcttcgccg tgatattgtc 646561 agtgttcatc aggaacatcc aagcaattgt aagtctgtag acgatattcg ggcaaacatt 646621 gcctatatgt gcgataaata caataacatc cgctccttag acgttcatct cgcttttaat 646681 gggccgttcc cgcctgacat gacgaacaga atcatggctg atattcaaaa gctgctggaa 646741 tcacagaaat atgatatgct gctgaatctg tttcttgagc ttctgcatgt tgttaaagag 646801 cgcaacattg atccggattg gcgaaagaaa tccccaaggg tgacggcgaa aagctttgat 646861 ttgcaaactg tccgcaagct tctgcctaag gcgaagaaaa agctaggcgt gaacgatttt 646921 gccaacgcac tgtatgcgct tgtcaacgat ttgctgcacg tggatcttag atcattggat 646981 gtggtataag tgagtacatt tcatttttca acgatagtgt caaggacaca tatctttaag 647041 ctcatgccta tgattcattc tctccatgag cattgcgatg attttcattt atatgtgctg 647101 tgtgtcgacc agaaagcgta tgaattgctt cagcacgttc catgggagca tgtaaccttt 647161 gtgcagctgc atgaaatgga agacccggag ctgttgaaag cgaaaagcaa cagaacgttt 647221 catgaatatt gctggacgtt aaagcccgcc tttttgtttc atgtgatgag caagtgggat 647281 gacgctgaat actttgccca tatggatacg gatctatttt tcttttctga tccggcacgt 647341 atttttgcag aaaacccaac ggcgtctctg tatttgactg atcatcgtaa ttcgccgcgc 647401 ttcatgtcct actacgaccg aaccggacgc tttaatacag gctttgtcgg cgccggtaat 647461 acaaaggaag catatgaagc ggtgtggcag tggagacagg actgtattga attttgcacg 647521 gtcgaaatgg atacggaacg aaagacatat ggtgatcaaa gatatgtgga gaaatggccg 647581 gagcagttta aaggtgttca tgttgtcaaa tccataggag ccaatacagc gctttggaat 647641 atcgaaaact ataaggtcgg gcaaaaggac ggccgcgtgt atatagatga aacgccgctg 647701 attttctatc atttctctgg gtttacgctg gtgacagaaa aagagtttaa tctttgctgg 647761 tactaccgga ttgaagacga agcgacaatt aagatgattt atatgcccta tatattaaat 647821 ctgaaaagat ggattgatga aatacagtcg gcgtttccgg actttgcgga tggctttatc 647881 ccgaagcacg cagtgcctga cactcatttt atccagctgg attaaaaaac cccctgccgc 647941 ctggcagggg ttttttcagc tatgccattc tctcagcttc tggtcacttg gcaataggaa 648001 ggcaaggatg ccgaggacag ggagaaaggc aatggcgatc atcgtcgggg tcagtcccgc 648061 ggcatcaatc agagcgccca gcgccacagc gccgattgcg cccatcccga aggcaagccc 648121 gacggttaaa ccggacattg tgccgatttt tccaggaact agctcctgtg cgtagacgac 648181 cgttacagaa aagctcgaca tcagaaccaa gccaatcaat gcgagcacgc cgtaggcgag 648241 aaccgggccg gcaaatggca gcacaatcgc cagcggcgcc gagcataaca gcgaaccgag 648301 gataacgaag cgttttccaa aacggtctgc aagcgggccg ccgagaaacg tgccgatcgc 648361 gccgaacagc aagaagacaa aaatatagct ttgtgcctgc tgaatgctta cgtgataggt 648421 atccatcgcg taaaacgtgt aaaagttacc gatcgcactc gtataccaag aacgagcaaa 648481 aatgagaaat ataataataa taagagcaga tacaacagat ttggtgatgg ccgtgttttc 648541 agccgttttc ttttgcttgc ctgatttctg ggcaaggctg ccgagacgtg aggcgtacca 648601 tttcgcaata tacatgagaa acataacagc aagcgcggcg acaagcgtga accaaacagc 648661 gccgaattgc ccgagcggca caaggatcag cgcggtgatc agcggtgcca tcgcctggcc 648721 tgagtttccg cccacctgat aaatcgattg ggcgagcccg cgttttgtgc cggcggccat 648781 atacgccaca cgggagccct ccggatggaa aatggccgag cctaatccaa tgaaaaacac 648841 acagcataag atcgttatga atgacggggc aaatgcaagg cccaaaatgc caagcatgct 648901 ggcggtcaaa ccgactggca gcgcatacgg ccgcggccgt ttatcggtat accagccgac 648961 aacaggctgc atgacggatg acaccatgtt taatgtgaaa gcaatgatgc cgagctgtgt 649021 aaacgtcagg ctcatggagc gttccaaaat agggaacatg gccggaatca cagcctgaag 649081 cgaatcgttg agcatatggc aaattccgat aataatcaaa atcggataca ccgtggtgcc 649141 tggtttttga actgtttttt cttttaacgg ggcggcgata gccattgagt ctcctcctta 649201 catatataac caaagcatac caccatatta ttcataaggt gaagaattta tcaagaggaa 649261 aaaagattct tatgaaagaa ataccgtcag cctgattagc agctgacggt attttcgata 649321 ttcaaaatgt gatatagctc ttcaagctta cgaatctcat aggttggtat gatctctggc 649381 acattcggct tcatgtcagg gttcatccag caagtatcaa gcccggcgag ctgtccgcct 649441 ttgatatcag cagttagtga atccccgatg attaatgtgt gctctgctga aaattgagga 649501 atccgttcaa acacgtaatt gaaatattcc ttcatcggct tttggaagcc ggtgtcttca 649561 gaaacgaaaa tgtccttgaa gaatggaaat aatcctgaat cacggagacg cttatattgt 649621 gtgtgagaca cgccgtttgt cacgatgtac aaatcaaact gttgctgcag atttgagatg 649681 agatcaaatg caccgtcaat aagctgatgt ccttcttcaa gaaagcggcg gtatttttgc 649741 tcaagcaaag cgccgtccgc ttcgtaaccg tactccttga gcaaagcgga aaaacgtgtg 649801 tttacgactt catcccgtgt catcttacct tcttcaaagg ctctccagag accttgattg 649861 atggttttat actgcgcctt catgtcattt gttaaaggaa tgttctgatc ttcaaacagc 649921 aaacgcaggg ctaaagcttc tgccgcttga aaatcaagga tggtatcatc tacatcaaat 649981 aataaagtgc ggtatcgctt catctgtgtg tctccctttc tcatatgtat tcaaagtata 650041 gcacataaaa aaaggaaaaa gccggcgggt gaggcaccgc cggctgaaaa gagattattt 650101 gtttaataag ctgtgttttc tcgaatatag gaagtaaacc agcgttccga cagcgatcca 650161 gatgacaaat gaaagccatg tgacgccggg aaggctgtac atgaaccaaa ggcagatgcc 650221 tgcgctgata atcggcacaa ccggaacgaa tggcactctg aaggacgctt tgatttcagg 650281 atgtttcttt cttaacacaa tgacagcaat ggaaatgacc gtaaacgcgg caagtgttcc 650341 catgttcacc agatgggcca gcgttccgag gttaataaag ccggcgattc ccgctgcaac 650401 gatccctgtc agccatgtgt tgcggaacgg ggttttaaat gacggatgaa cctttgcgaa 650461 caatccaggc agaaggccgt ctctgctcat ggcaaatgtc aagcggacct gtgcgtacag 650521 caaagcgagc atcaccgtcg taatcccgat aatcgcaccg acagaaataa ttccggcaac 650581 agcgtcctgt ccgacgaatt tcagcgcaaa ggatacagga tctccgacat tcaatttggc 650641 ataaggcatc atgcctgtca gcacaagcga taccgcgatg tacagaaccg tacagacggc 650701 tagagctgaa ataatgccga cgggcatgtt tttttgcgga tttttcactt cctctgatgc 650761 gttagaaacc gcgtcaaacc caaggtacgc gaagaataca gtggcagcgc taagtatgac 650821 gcctttcatc ccgaatggca taaaaggaga ccagttatcc ggtttcacat agccgatgcc 650881 gacaataatg aacaataata tgatcgcgat tttcatcagt acgatgacgt tgttaaagcg 650941 tgtgctttcc ttgacgcctc tgctgacaat cgcagtgatg aggagaatga tcaccgcagc 651001 cggaaggtta aatacggcgc ccgccatgct tcccggcgct cctgtcagtg cagccggaat 651061 atgaagattg aagccggcaa gcagtgattg aaagtatgaa gaccagccgg tggcaaccgc 651121 cgacagtgca atgacatatt caagcatgag atcccatccg atcaaaaagg cgagcagctc 651181 tccaagtgtc acgtatgagt atgagtacac gcttcccgaa atcggaatgg aagacgaaaa 651241 ctcagcataa cagaaagcag ccagcgcaca ggcgagcccc gctaaaataa acgatatgat 651301 gagggcggga cctgcaccgg tcgctgccac tgttcctgta atgacaaaaa tccctgtacc 651361 gatgacacaa ccgataccga gcaaggttaa atcaaatgcg cttaacgtac gggcaaggct 651421 ttttgacttg ctctgcgcac tcaatgtttc aagcggtttt tttctaaata atgaactcat 651481 caaaagttcc tcctagaaat attcaaaata ttctaatcat tatatgcagt tcttgttgta 651541 ttatattgtc gaaatttgac gtagtcaata aaatattttt ctgctttaaa tgatagaagc 651601 gaaacagcgt tgtcgtatca taggatagta atttttacta atcgtatatt caattttatg 651661 caagatgaac cgatagaaaa aatagattcg cccatatttt gatttgcggt tataaaggag 651721 atgctgacca tgtttcaata tgaagagttg aataaacagt ttatcggcgg gaaatggcag 651781 gagggcagca gcccaaatgt attggaaaac aaaaatcctt atactcaaaa aacattcaca 651841 acattccgta aagcgactgc tgacgatgta gatgaagcgt atcgggcagc ggcgctggca 651901 aagaaaaaat gggatgcggt caacccgttc gagaaaagaa ccattttaga aaaagccgtc 651961 acgtatattg aagaaaatga agaagccatt atttatttga ttatggagga gctaggcggt 652021 acaaggctca aagcagcttt tgaaatcggt cttgtcaaaa acatcataaa agaagcggca 652081 acgttcccaa tccgcatgga ggggaaaatt cttccgtcaa caatagatgg caaggaaaac 652141 agattatatc gcgtgccggc aggcgttgtc ggtgtcatca gtccgtttaa cttcccattc 652201 tttttatcta tgaaatcagt ggcgcctgca ctcggagccg gcaatggcgt tgtgctaaag 652261 ccgcatgagg aaacgccgat ttgcggcgga acgctgattg cgaaaatttt tgagaacgcg 652321 ggaattccag cggggctgct gaatgttgtt gtcacagaca ttgctgaaat cggcgacagc 652381 ttcgttgagc atccagtgcc gcggatcatc tcatttaccg gttctacgaa agtcggcagc 652441 tacatcggac agcttgcgat gaagcatttt aaaaagccgc ttcttgagct tggcgggaac 652501 agcgccttca tcgtacttga ggatgcagat atagaatatg cggtcaatgc ggcggtgttc 652561 agccgattta cacatcaagg gcagatttgc atgtcagcca accgcgtgct tgttcattct 652621 tctatttatg acaagttcct tgagctgtac caggcaaaag tggaatcgct gaaagtcggc 652681 gacccaatgg accctgatac gattatcggg ccattaatca acagcagaca gacggacggg 652741 ctgatgaaga ctgtagagca agcaattgaa gaaggcgctg taccagtgaa gcttggcgga 652801 tttaacggga cgatcgtgga accgacgatc ttaaaagacg tcaaaccgtt catgagcatt 652861 gccaaggaag agctgttcgg accagtcgtc tcctttatga agtttgattc agaagacgaa 652921 gcggtggata tcgcaaacga aaccccgttt ggcttgagcg gtgccgtaca tacgtcaaat 652981 cttgagcgcg gcgtggcttt tgcgaaacgc attgaaacag gcatgattca cgtcaatgac 653041 acgaccatca atgatgaacc gaatgtagcc ttcggcggtg aaaagcaatc aggcctcggc 653101 cgtttaaacg gtgagtggag cctcgaagaa tttacaacgc tgaaatggat ctcggtccag 653161 cacgaaaaac gcagcttccc ttattaatga aaaggagtga atggaattga ccataaatac 653221 ggaaaaagaa accgcagata ttctggacgc atttatcaaa gtagcccctt atttaaacag 653281 cctggttcag gatgatatta caatcggcat ttatgatacg gaaaaactgc tcgtgaatat 653341 accggccaaa accttttcgc tgaacgtaaa agccggcgat ccgctgcagg aaggggatat 653401 catcacagat gccatccgca gcaatcagaa gaagacgagc atggttccga aagaattgtt 653461 cggcttccca ttgatcgcgc gtgccatccc gctgcacgac gagaatggaa gagtcattgg 653521 aggcgtcggc ctcggaacga gccttgagga gtcgtcaaag ctgcatgatg tcgcggaaag 653581 cttatcagct gttgttgaac aaacagccgc ggctatttcc gacatttctg aatcaattaa 653641 cgggttttca actcaaatgt cgggcatttc ctctcaggcg aaaaaagtaa gcgaaagcgc 653701 cggtgaaatc gccgatattt cagtaactgt taaaggcatc tcggaccaaa gcaatctgct 653761 cggcttgaac gccgcgatcg aagcggcaag agcaggggag tccggaaaag gattctctgt 653821 cgtcgcagat gagatcagaa agctagcgac gcattcaaaa gaaaatgtcg gccaaattga 653881 ccagattacg aaaaaaatcc acagcctgct gaaagggctg gaggaatcca ttgagtcgat 653941 taaccagcat acagacggac aagccgctgc tgttgaacaa atttccgcca cgatgcagga 654001 gatttcagga agcgcgcagc atcttgcgaa aatggccgaa aaagcgcttg aggaagagta 654061 agagaccggg gacaaacatc cccggtcttt ttcttatcct gcatttccat gaaattcgtc 654121 tgacgtttta ctagttttat tccagcggct gatttaaaat gtacacatga acttacgtga 654181 ggattgatag gaaccatgag catattaaaa gcggaaaatc tttataaaac atacggagat 654241 aaaacattat ttgaccatat ctcctttcat attgaagaga atgagagaat cggattaatc 654301 gggccgaacg gaacaggaaa atcaacgctg ttgaaagtga ttgccggctt ggaatctatc 654361 gaagaaggag aaatcacgaa atccggaagc gtgcaggtcg aatttcttca tcaagacccg 654421 gagctgcctg cggggcaaac agtgctggag catatctatt ccggtgaatc ggctgtgatg 654481 aaaaccttgc gtgaatatga aaaagcgctg tatgaactgg ggaaagatcc cgaaaatgaa 654541 cagcgccaga aacacctgct ggcagcacaa gcgaaaatgg acgcgaacaa tgcatgggat 654601 gcaaacacct tggcaaaaac cgtattgtct aagctgggcg tcaacgacgt aacaaaaccg 654661 gtcaatgagc tctcaggcgg ccagaaaaaa cgggtggcca ttgccaaaaa cttaattcag 654721 cccgctgatt tgctcatttt ggacgagccg acaaaccatt tggataatga aacgattgag 654781 tggcttgaag ggtatttaag ccaatatccc ggcgccgtca tgctggtgac gcacgataga 654841 tatttcttaa accgtgtcac caaccgcatt tatgagcttg aaagaggcag cctctacact 654901 tacaaaggca actatgaagt gtttttagaa aaacgcgcgg aacgggaagc gcaggctgag 654961 caaaaggaaa cgaagcggca aaacctgctg cgccgcgaac tggcttggct cagacgagga 655021 gcgaaagccc gctccacaaa acaaaaagcg agaattgacc gggtagagac gcttaaagag 655081 cagacaggcc ctcagtcatc aggttcactc gattttgcca ttggctcgca ccgtctcgga 655141 aaacaggtta ttgaagcgga gaacgtcatg atcgcttatg acggccgcat gctcgtcgac 655201 cgttttaatg aacttgtcat accaggtgaa cggatcggga tcatcgggcc gaacggcatc 655261 gggaaaacaa cgctgttaaa tgcccttgcc ggccgtcata cgccggacgg aggcgatatt 655321 acgatcggac agacggtcag aatcggctac tatactcagg atcatagtga aatgaacggt 655381 gagttaaaag tcattgacta tataaaagaa acggcggagg tcgtaaaaac ggcagatggc 655441 gatatgatta cagctgaaca aatgctcgag cgtttcctct tcccgcgttc gatgcagcag 655501 acgtatatcc gcaagctgtc cggcggggaa aaacgccgtt tatacttgct tcaggttctc 655561 atgcaggagc cgaatgtcct gtttctcgat gagccgacga acgatttgga tactgaaaca 655621 ttaagcgttc ttgaggatta tattgaccag ttcccaggcg tcgtcatcac cgtatcccat 655681 gaccgctatt tccttgaccg cgtcgtcgac cgtttgattg tatttgaagg aaatggtgtc 655741 atttcccgct ttcaaggctc ctatagcgac tatatggagg agtcaaaagc gaaaaaagcg 655801 gccccaaaac cggcagctga ggaaaaaacg gctgaagccg agccgaagaa aaaacggaaa 655861 aagctttctt acaaagacca gttggaatgg gacggcatcg aagataaaat tgcccagctg 655921 gaagaaaagc atgaacagct tgaagctgac atcgccgcag caggcagtga ttttggcaaa 655981 atccaagagc tgatggccga gcaggcgaaa acggcggaag agcttgaggc tgcgatggac 656041 cgctggacag aattgtccct catgatcgaa gaactggaaa gctaaaaagc gtggccgcag 656101 caggccgcgc tttttttcac ataatggaca aaaacgaacc ggcctgctta tgttaggata 656161 aagttgtgtg tcagcggcac atggaaaact aacggagatg atgaagtatg acatgggcga 656221 tcgtgatgtt aattctcatg agtctggtga aaatcgtatt aacctgtctt cctacaggcg 656281 tcatagaatg gctgctcggc aaatttgaag tgcacgccaa gctgagtgac gaaaatgcga 656341 gtctctctct agatggaaaa cgcctcgagg gtgcagagaa gcagaaagtg attgatcaat 656401 ttaacgaagc tatcttcctg gaaaaatatt atatctatcc aggtgatgaa gagcgttatt 656461 tacatccgga aaacggcggc acgcctctgg tgatagatac aaaaaaagga aaaaaagacg 656521 tgaagctgtt cgtgtaccgc tacgacgacc atatcgacgt cgtgaaacag tacaagaaga 656581 aagtgatcgc gtatcgagtg ctttctgaaa gccttcaaaa agagtctctg tcagtggcgg 656641 gaagtttagc ttaaacagga aagtgaaaga cgggtgctgt atgctgctcg tcttttttat 656701 tgttttttaa aacttaacgt ttacgttaag gttcaaaagg tgtataatgg taacagaaac 656761 ggcgaagggg gatttacctt ggaatggatg aagattgatc aagtggccaa aagaagcggg 656821 ctgacaaagc ggaccatccg gttttatgaa gaaatcggct tgattccggc gccgaaacgg 656881 acagacggcg gtgtaaggct ttattcagag gatgatatgg aggagcttga gaaagtcatc 656941 agcacaaaag aggtgctcgg tttttccctt caggagcttc agcatttcat ggaaaccagc 657001 cgccagctag agttaaacaa agaggggtat ttgttgtcac tggatcctaa ggaacggaaa 657061 gaaaaactgg aggaaattca ggaaaccctg aatcaccagc tggatttgat tgatgagaaa 657121 atccgcacat tccaaagctt taaagaacgc ctgcagggca tgaaaggcaa agcggaacgc 657181 gccattcaat caatcgaatg aaaagtttgt taaacgctat ttttgtagcg tttcttttaa 657241 tggaataaag atggaggtta ggtcaaatgg ataagacaac acaagtgaat cagaaaacgg 657301 gtttgctcag ccagccaaaa gcggtatggg ctgtcgcgtt tgcctgtgtg atttctttta 657361 tgggaatcgg gctggtcgat ccaattcttc cggccattgc cgcacaattg catgcttcac 657421 ctagtgaagt atcactcttg tttacaagtt atttgcttgt aaccggattt atgatgtttt 657481 tctcaggagc catttccagc cgcatcggcg cgaaatggac attaattctc ggacttattt 657541 ttattattgt gtttgcgggg cttggcggca gctcaagctc aatcgctcag ttagtcggct 657601 atcgcggcgg ctggggatta gggaatgctt tgtttatttc aacagcgctt gcggtcatcg 657661 ttggcgtgtc agtcggcggc agcgcccaag cgattatttt gtatgaggcc gcgctcggtc 657721 tcgggatttc tgtcgggccg cttgcaggcg gagagctcgg aagcatttca tggcgcgcac 657781 cgttttttgg agtatctgtc ctgatgttta ttgcgttaat cgcgatttct ttcatgcttc 657841 cgaagctgcc gaaaccggcg aaacgcgtcg gtgtgtttga tgcgatgaag gcactcaaat 657901 ataaaggcct gctgacaatg gcggtatcgg cattcctata caactttgga ttttttattt 657961 tgctagctta ttctccgttc gtactggatt tagatgaaca cggtcttgga tatgtcttct 658021 tcggctgggg ccttctgctg gcgattacgt cagtctttac ggcgccgctc gtgcacaaag 658081 cgctgggcac agtgcgttcg ctagtcgttc tctttatcgc ctttgcggcc attctcgtta 658141 ttatggggat ctggacagac catcagactt tgattattac atgtatcgtt gtcgctggtg 658201 ctgtcctcgg tatggtgaat acgatcatga caaccgctgt gatgggttct gcgccggttg 658261 aacgttcaat cgcgtcttca gcctacagct cagtccgctt catcggcggc gcgctcgccc 658321 cgtggattgc aggaatgctg tcagaacact ttactgcaag cacaccatat acagtaggcg 658381 gaatcgtcgt ttttgtcggc atgcttgtcc ttctcatggg acgtaaacat cttgctggaa 658441 ttaaggcggg gcattaataa cgaaagacac tgcgcatatg cagtgtcttt ttattcgtta 658501 taatgcatca taatcgaatt ggtgcaggaa aggacaacct ttatgacaca attttactat 658561 tttccggctg aaaactccct ttagaaaccg gttttttcgg tcagcaagaa cggcgttcgc 658621 ggaaagggca tccgcttcgg tcaggcattg atgcggctgg gatttatctt gcagaagctg 658681 agaatgtgtc cgttcattta cgattgccat ttcagtgatg gttcatgctg tagaggggac 658741 gtttgccatg gataaggcaa aacctgacga atatgatcag aaatgtttag aaacgctcta 658801 tcaatacata cacagcgtca tgaaaaacag cttttctcgg tcgagtggtt taccgcttgg 658861 gaagatgagg aggattttga gctgtctgcc aaaagagagc tgacacttga tgaattcaca 658921 tctccattgc agctcatttt aaaagacaga gagcttttga gaatcgttca gaaaaaatgg 658981 cagtaaaaaa cccgcccttt agcaggcggg tttttttata aattaaagca ctttcgtcgt 659041 ccaagactcg cagttccacg tttctgtcgc aatatccata taaaagtctg gctcgtggga 659101 aatgagcaga atggagcctt tatattcttt cagggcgcgc ttgagctctt ccttggcatc 659161 ggcatccaag tggtttgtcg gctcatcgag caccagcagg tttgtttctg agttgattag 659221 cttgcacaat ctgactttcg ctttttcgcc tccgcttaat acggagacgc ggctttcgat 659281 atgctttgtc gtcagcccgc attttgccag agcggcacgg atttcatact gcgtataaga 659341 agggaattcg ctccatactt cttcgatgca cgtattgttg tttgtttcct tgacctcttg 659401 ctcgaaatag ccggtataga tgtgctcacc gcgttcaaca gagccttcga gcggctggat 659461 ttcaccaagc aaacttttca gcaatgtcgt ttttccgatc ccattcgcgc cgtaaagggc 659521 gattttttgg ccgcgctcca tgcggaggtt gagcggacgg gacagcgggg aatcgtaacc 659581 gatcacgaga tccttcgttt caaaaatcag cttgcctgac gttctcgccg gcttaaagtg 659641 gaattccggc tttggctttt ctgccgcaag ctcgatcata tccatcttat cgagtttctt 659701 ttggcgggac atcgccatgt ttctcgtgct gacacgcgct ttgttgcggg cgacgaaatc 659761 cttcagctcc gcgacttcct gctgctgctt tttgtaggcc gcttcaagct gctgtttttt 659821 cacctcgtag acttccataa actgatggta gtcgccgaca taacgtgtca gctcttgatt 659881 ttcaacgtga taaatcaggt tgatgacact attcaagaac ggaatatcgt gggaaatcag 659941 gatgaacgcg ttctcgtatt cctgcaggta gcgtttcagc cattcaatat gctgttcatc 660001 aagatagttg gtcggctcat cgagaagcag aatttccggc ttttcaagga gaagcttagc 660061 gagaaggacc tttgtgcgct gtccgccgct caaatcggtg acatctcgct ctaaaccgat 660121 atcgctcaaa ccgagaccgc gggcgatttc ttccaccttg gaatcaatga cataaaaatc 660181 attgtttgtc agcgcgtctt gaatgacgcc gacttcttca agcagcttct cgagctcgtc 660241 gggatcagcc tcgcccattt tgttgtaaat ctcgttcatt tcctcttcca tcgcaaataa 660301 ataatggaat gcgtctttca ggacgtcgcg aatggatttt cctttttcca gcacggtatg 660361 ctgatcaagg tatccgacac ggacattttt tgaccattcg acttttccct catcaggttc 660421 aagctttccg gtaataatat tcatgaaggt tgattttcct tcaccgtttg cgccgatcaa 660481 gccgacgtgc tcgcctttta acaggcggaa ggaaacgtta ttaaaaatgg cccggtcccc 660541 gaaaccgtgg cttaaatcct ttacagataa aatactcatg tttacacctc tatcgttatc 660601 aaacacgcac aatcggcgtg taatattcac ccttttgatt ataaaggagg attcggaatg 660661 ttgaaaggta taggaaagaa aaagaaaaat tgcgttccgg gcgaggtttt gagatactat 660721 ggaatagatt tcaggaattg aggagaacaa aatgacgcaa acttggccat ttttacataa 660781 tgcacaatca tttatacaag agaattggaa tgcttccggc tttcaaaagc caacccctgt 660841 tcaggagcag gcagcccagc tgatcatgga cggaaaggat gtcattgcag aatcgccgac 660901 aggcacaggg aagacgctgg cgtatgcgct gccggtcttg gagcggatca aaccagagca 660961 aaagcatccg caggcggtga ttttagcgcc ttcccgtgag ctggtcatgc agatttttca 661021 ggtgattcag gattggaaag cgggctcaga gctgcgcgcg gcttccttaa tcggcggggc 661081 gaatgtgaag aaacaggtcg aaaagctgaa gaaacatccg catatcatcg tcggcacgcc 661141 aggcagggtg tttgaactga ttaaagcgaa gaaactcaaa atgcatgaag tgaaaacgat 661201 cgtgcttgat gaaacggatc agctcgtcct gccggagcat cgcgaaacga tgaagcaaat 661261 cattaaaaca acattaagag accgccagct tctatgtttt tctgccacgc tcaaaaagga 661321 aacagaggac gtgctccgcg aattggcgca agagcctgag gtgttgaagg tgcagcgaag 661381 caaggcggag gcagggaaag tgaagcatca atacctgatt tgcgaccagc gcgacaaagt 661441 gaagctgctg caaaagctgt caaggcttga aggcatgcag gcactcgtat ttgtgagaga 661501 cattggcaac ctgagtgtat atgcggaaaa actggcatat caccacgttg aactcggcgt 661561 tttgcacagt gaagcgaaaa aaatggagcg agcgaaaatc attgccacat tcgaagacgg 661621 agagtttcct cttttattgg cgactgacat tgccgcacgc ggtttagata ttgaaaacct 661681 gccatacgtg attcatgctg atattccaga tgaagatggc tatgtccaca gatcaggacg 661741 aacaggccgg gccggaaaag aaggcaacgt gctgagcctt gtgacaaaat tggaggaatc 661801 taagctgaaa aaaatggcga agaagcttgg tgttgagctg agtgaagctg tgtatgcagg 661861 cggaaaactg aagacgaaat aaaaagaagg gcgaagagcc ctttttttgt tgtaaaataa 661921 tagaaaagat tttgcgcgga ggtgggaaaa tggcttcaat agacaggttt caagtaatgc 661981 aggagccaga gctgaaaatc cttgaacact ggtttgagaa tgaggatacc agacggagaa 662041 tggatgggat gctgctatta gatgagtggt atgcacgagt aaataaagat aaacacgata 662101 ctgtcatcat ggcgtatgat ggacagctgc cggcagggat ggtcgttatt gagttcggag 662161 aggagcggac atatattgga ttgatcgtca atcctttgta ccggcttaaa gggtatggaa 662221 aacagatact gcaaaagctg atgaccgaac ctgattttac tagcgtgcga gaatgggtgg 662281 catgcattga agaagacaat cgaatcagtt tagcttgctt tcaagcagca ggattcactt 662341 tagaagacac ggaacctgat gaagatggtt ttcttacgct gattcttcgc aactgatctc 662401 atcgaaacac aaaaggaggg caaaaagccc tcccgttttc atcttcattc agctcggatc 662461 actgaccttg atcagctgtt tccctttatt ttctccctta aataaaccga gaaacgcgtc 662521 aggaatgttt tcgaagcctt ctgtgatggt ttcctcgtaa tggagtttac cagccttcag 662581 ccattctgcc agctgttttg ctccctcaga aaaacgatcg gagtagtcgc ttacgataaa 662641 gccttgcatc agcgacttcg ttttaatgag ttttgattgg acacgagggc ccatgtcatc 662701 tgcttcgctt tctgcgttat aggaagaaat ggcgccgcac accggaatgc gggcaaattc 662761 attgagcaga ttcatcaccg cgtctgaaat cggtccgccg acattgtcaa aatacacatc 662821 gacaccgtca ggacaagcgt tttgaagcgc tttttggata tcatccgctg ttttgtaatt 662881 gatggcttcg tcaaactgaa gctcctgttt taaatagtcg attttttcat cagagcccgc 662941 gatgccgacg actcgcgcgc ctttgatttt ggcaatttgc ccgactgttg aaccgacggc 663001 tccggcagct cctgagacaa ccacggtttc gccttccttc gggcgtccga tgtccagcaa 663061 tccgaagtat gctgttaagc cggtcattcc caaaatgccg agataggccg aagcgggagc 663121 aaggcttgta tcaatttttc gcaaggcaga ctcgctcaca gcggaaaatt cctgccagct 663181 gagatttccg atgacgatat cgcctttttt cagatgattc ccgtctgaca caacttcagc 663241 gataacccct ccagaaagcg ctttatccaa ggcgaacggc tcaacatatg acttcgtatc 663301 ctgcatacgg ccgcgcatat aagggtcaac cgatacataa agcgttttga caagcacttc 663361 cccttgcttg ggttcaggaa ccggaatggt ttcaaagcga aagtcttcat gaacaggaat 663421 accttgtgga cgtcttgcta attgaatttg ctgctgagat gctgtcattt tcatcctcct 663481 atcacttggt tgacaccact gtaacatgga caggagagga aatacaaaag gtaagctggc 663541 atacaaaaaa ggttatagat gagcttatgc tttctacaag ctcttttgtt ttaaaagttc 663601 tctttagtca tttatcatta ttagaaaaca gaacagaaaa agagctcctg tacacctagc 663661 taagattggc tagtgtgtat gtcgattctt tttcatattc ttgcaagcat ctgcgagggg 663721 gagcttagtc gttcacattt tgctttcgca tcaatctgca atagcaaagt ctatgcgatt 663781 tttttacatc agcaaagatt tgttcaattt tttcctttta tgccgagttt ttctgaaaca 663841 gataattgat ggtactcaac cattttcttt tggtcaataa agtaatgttt acttattaat 663901 taaacacgcg aaaaagcaaa cgaaaacata attaaatttt atatatttat taaaagctta 663961 tatgtttatt tacctttttt ttgaattgta attgagaaaa tccatatatt gcggacacta 664021 ataaaagaat acctgctgaa acataaacta aacgaactcc aaggaaatct gaaatagccc 664081 ctatagccag aattgaaaac ataaaaatga actgtactaa agaagacctt gcagacatta 664141 tattaattcg agtttgctcg gttgttatgt tctgaataag tgtttcttgt gtaagatctc 664201 ttaatatata agccggcccc ataaagagaa ccaaaattag agctaagtat gaattactta 664261 taaaaccata tattaaagtt aaacttccat atgagacagc gccaattaac ataaaattaa 664321 ttaacttatt ttgaaatctc tccgacagct tatatattat aaatccccct atcatcgaac 664381 ctaaataata tgctccatta ataaatcccc accatgattc tcctttatgc aagacttcgt 664441 taacgaaagc taaagagaca gatcctatcc aaatcattcc tgcccatgac tcaattaaat 664501 ccataataat aattgttcta agtttctttt ggctaaataa ataccgccaa ccacttacta 664561 tactcttatt gggagaattt ttttcacgta tgacagaatt agcgtggcca tgtggtagac 664621 aaaataaaag agaaagaaga gatgtaaaca acaaaaagat agtaagtata atggtatatc 664681 cctcacctaa aaatgcaatt atgagaccac ctaaagacca gcctacaaat tgaaaagttt 664741 ggtccactgt agataataat ccatttgctt ttactcttct atcaggagag attatttccc 664801 ctataattgc actttttaaa ggtgagaacc atccattaaa aaaggaaata cagctaataa 664861 taataaagac taaaatgaga gtttgattag agtaagttct taataaagca tagaacaaac 664921 atattaataa cagcatttgt atcaattgag aaataattat tgtaagaggc agttttaatc 664981 gaattgttat taacggtaat atagcacttc caaaaatacg aaaaataata cttattaatg 665041 tcaccataga ggcgatggtt gtcgaattgg tcattttaaa caaaaacgaa atcactacca 665101 tagtatatag agaaaaacct aaatttgtag tggtctggct aaataaaata gaataataac 665161 ctttactcat atgtatcctc ccttggaata atttttctcg gtaaagagct taaacatatt 665221 taaacacctt aaaacaacaa aagtaaagaa aaaatttcct tgtaaactat ttacttttat 665281 tctatttatt gttattgttt atttaagttc tctgactatt ctatcaatat tcagggaacc 665341 acatatctta ttaaaggggg gaaaaccatg agaaaattaa gaaaaaactg gagaaaatcg 665401 attgttagcc cggttcttta tactaatgaa aaatggtaaa cacttaggga atagcattta 665461 atgctattcc ttatttcaac aaacaaatcg ggaggttatc gtaatttgac tctattaatg 665521 caagatcata aatcaattta caataaagat atagaaatat taattgaagt tgaagaactt 665581 attacttctg ttccagaaaa taaaaaaaat gattttaaga gtttaatcga taatagaatt 665641 atgactctac taaataaaat tcaacaccct gtagcagcgg aaaatgtgtt tgggatgtgt 665701 attgcttatc cgaatactta cataaggtat agattaattg atttcgttga aaaatgggta 665761 ccttatttct ctgctgtaga aactataatc aatctaaccc aggatccgga tgatttagtt 665821 tcttttaaag ctatggatgt ctgtgcaaat cataaaattg aagaatctgt agcatatttg 665881 tcttcgatta ttgatgatgt ccgggagagt ataagctacc ctaaaaaacc tgtgggatta 665941 ggggcccaaa aagtattaag tacattatta gatatattcg gtgttgaaaa acatgaagag 666001 ctagtaatgc taaaaaatta ttttgatcaa aatggtatac ttcctaataa ctttgacttt 666061 gaagaaaaaa ttcctcaaag tctaatagag gaattcgaaa aaacagaaga agatgggatg 666121 attttaattc cgggtggctt ttttgaattc ggtttaaatg aaaatgaaat tcctgacaaa 666181 acatttaatt ggaaagatgc tgttcctaga caaaaagtat ggttacctcc attttttatc 666241 gataagtatc ctgttacaaa taaagattat gatatcttta ccgagttcat agaggaaaat 666301 gggcatatat tctgtcatcc taatgaaccg cagaataaac aacatagaag aaatacatat 666361 tgggatgata ggtatttaga taatcatccc gttacaggta tagattttta tgatgcattt 666421 gcttacgcaa gatataaggg gaaagaattg ccaaccgagt ttcaatggga aaaagctgct 666481 cgaggcgaaa agggtaatgt ctggccttgg ggagataaat ttgatcctgc aaaggttcaa 666541 tatgctggaa gtctttataa tgaacccatt acttctttaa agtcctggag agaaaattta 666601 ttaaaagctc atgctgataa agaattaaat catttaacaa gtgatatttt tgaacaaaat 666661 ggtgaaagtc cctatggagt atgcggtatg atcggcggaa catgggagtg gactagaagt 666721 gagcttaaaa caaagagagc tttccaccct atttttgaga atgtaccatt taatagtgtt 666781 aactcatttg ccgttcttaa aggaggatca ttcttctctc atccaggctt aatgttccct 666841 tcttttagag caaaagatat tcctttctgt cgacacaatg aaatggggat tagatgcgta 666901 aagaatattc cagtatataa aattagagaa tcaattaatg ggccaattac taataaagca 666961 atttattaat cattctaggt tagagacttg ataaaagtat actaacattg tgtagtaatg 667021 ttcagcttgt agaaaaaaca atgttttttc tacaagattt tattttaaat gcttttcaaa 667081 attatcaggg attgagaatc agaaaaagag ccattaagct cgatcttagc taggtattac 667141 gatcttctgt atattattgt gagaaatata gaagattcag ttagttagca tttcgatttt 667201 aagctgagcc tgcaatagca aagcatctgt tttgattatt ctttttctga tacataagct 667261 aattttgtcg cttttctttt ttgtcttttc acgcatttcg aggatgactt actataattc 667321 tttcagcttt tctatgtgtt aagattcgaa tagatgaaat aactttaaca agttggtcaa 667381 taagaacaga tttaacttta tgttaaaaga gtatctcgta tagaacataa gaagaatgac 667441 gagtttttta agattatcat caattatgtg agaataaaat attataaggg aaaatgaagg 667501 ctgtcacgtt tctcgacagc cctagggaat tcctctcctt ttcatttcgc ccgtaatttc 667561 gggcacagtc ccgtcggcag gcacattggc ttctggtcga tcgggcttct catgatgcag 667621 cattccaagc cgaagacttc acggaaaaat ggctgggtga acacatcttc cggtgttccg 667681 gcgttgtata tttttccgtc cagcacactg atcagatagt cagcatattg agcggcttgg 667741 tttaaatcat ggagcaccat gacaacggtg cggccatggt cgcggttcag ctttttcagc 667801 agttcaagca cttcaatctg atgtgagatg tctaaatacg tggtcggctc atcaagcaaa 667861 agcaaatcag tgccttgcgc aagtgccatg gaaatccagg ctctttgtct ttggccgcct 667921 gagagggcat caagtgtccg atccttcagt tcaatcatgc ccgttgcttc cagcgcccac 667981 tctaccatgt catgatcctc ttgggtatgc ttggataaca gctttttgtg aggatgtctg 668041 ccaaaatagc ataattcctc taccgtcaat ccttcaggag cctgaggaga ttgtggaaga 668101 atggccagtt tttttgcgac ttcttttgat ggctggcggt ggatgtcttt tccttctagt 668161 agcactgtac cgctttttgg ggccatcagc ctggcgagcg atttgaggat tgttgattta 668221 ccgcagccat tagcgccgat gagcgcagtg atttttcctt cttctatctt taagtcgact 668281 ccgtcaataa tcactgtact gtcatatgaa agagtgagct ggtctgcagc cagttttccc 668341 atggtatcct ctccctactg tttcctcgct tcgaatttca ataaatataa gaaataaggc 668401 gcgccgatca cggctgtcag tattccggca ggtatttcaa ccggaggcat gatgccgcgc 668461 cctaacgtat ctgcaattaa taatataata gcaccaatca atgccgatgc aggcagtaaa 668521 tatttagctt tttctccggt aagccgtctg gcgatatgcg gagcaagcaa gccgataaaa 668581 ccgattgagc cgacgacggc tacacagctt cccgccagcg ccaccgcggt gaaaatcagg 668641 atgaatctca gccggtttgc gttttctccg agaccctgtg caagctcatc cccgagtgac 668701 ataagatcca gcttcggtat gagtatgcag acgatcggaa aaagaatcaa aagccatggc 668761 gcaagcagct tgacttcttc ccagtttctt ccccagaggc ttcctgtcag ccaaatgagt 668821 gcagcattca cgtcgcctgg aaacttgacc atcatatatt gcattccggc gtggcagacc 668881 gcgcctaaag caatgcctga taaagccagt gaagagggct gaatgctctt ttttcgggct 668941 atcattaata atagtacagc aataatggcg gctccggcaa atgcggagaa cggaagcacg 669001 tataccggcg actcaggaaa gatgagaatc acagccatcg ccgcaagtcc ggagcctttt 669061 gaaatgccga caacgtccgg ggaagcgagc ggatttcgga tcacaccctg taaaatcgct 669121 ccggcagcgg caagtccagc acctgccaaa atcgctaata taatgcgggg aaggcgatat 669181 tgctggatga taaattcaaa ggaatgatcc agtcccagca gattcgtcac taccgcatca 669241 ggtgaaatgt ataatgcacc gattccaatg ctgatgacgg acagaacgat taaaatcacg 669301 gccaatatga gtatcgccag taaggggcgt ttttgttttc tggttgtttt cttcatttca 669361 ggtttcgccc tttccttgcc aaatataaga aaaacggcgt tccgataatc gcggtgacaa 669421 tgccgaccgg tgattcataa ggaaatgcaa tccatctggc cagaacatct gcgtacacca 669481 gcaaaatggc accgaacagt gccgaaaacg gaagcacgta ttgataatgt tctccgatca 669541 gcttgcggac aatatgcggg acgagcagcc cgacaaagcc aatcggcccg gcgacggcta 669601 cggaagcgcc ggaaagaatt aaaataatca aactgatcag aatcctgatg ccgttcatat 669661 tttgtccaag cccttttgct gtttcgtctc cgagaccgag aacagaaaca gaaccggaaa 669721 atacgagggc aagcccgatg ccaatgacag aaaaaggagc gatggttatg acgtcctgcc 669781 agttgctgcc gtcgattgcg cctgtcatcc agtacagaac atcctcacct gactcattta 669841 aaataatgat ggcctgtgtc atagaggaga ggaacaagtg cacggccatt cctgacagcg 669901 ccagcttgac aggcgtcatt ccgccggatg aggcaatcat atacacaatc gcgccgcctg 669961 ctgccgcacc cgcaaaagcg aatataacag atgaataggg cgatgccggc agaatgacga 670021 gagaagcaac aacaaaaagc gatgcacccg cattcacacc gaaaatttgg ggtgaagcca 670081 gaggatttct ggtcatagcc tgcatcagcg cccctgctac agctaggctg gcgccgacaa 670141 aaacgccgat taatgtgcgg ggaaggcgaa gagtagagat gatgagctgt tcctttgaac 670201 cgtcccatac aaaaagatat ttcaatgaat ctatgatgct gatgtctgag gctcctactg 670261 aaagattcag cccaagccca aatataaaaa taatcagtgc aatgataaac atcatcagtc 670321 ttgatgatga gcgccgtttg gctgaatgat acaacagtct cacttcctta ctgcgtctgg 670381 ttgcaaaaac gaagaagcaa ggattcccct cgcttctcat ttgtcctatt tattatacac 670441 ttttttaagc acatctttgg cgcttgtttc actagacttg atgcctctga atcttgtcca 670501 agtgtcacgg tccgcatcat agacttgtcc atttttcacc gctttgagat ttttccagag 670561 cgggttcgtt ttccactcat ctacaatggt tttgccttcg ttggctgaga tgaacaaaat 670621 atcaggatcg attttgctca attgctcaag gctgacctct tgataggcgt tatctgactt 670681 cacagcgtgt gtaaagccta gcattttaaa gatttctccg tcataggatg atgatgtatg 670741 aagctggaag gaatccgctc ttgcaacgcc gagaacgatg ttgcggtttt catctttcgg 670801 aagttcggct tttagatcgt tgatgacttt tttgtgctcg gcaagctttt cttttccttc 670861 atcttcttta tttaatgctt tagcaatggt cgtaaagctg tcgatcgttt cgtcatatgt 670921 cgcttcacgg ctttttaatt caatcgtcgg ggcgattttt ttcagctgtt tataaatgtt 670981 tttatggcgc tcagcgtcag cgatgattaa atcaggcttc aaggaactga tgacctcaag 671041 attgggttcg ctgcgtgtgc ctacagatgt gtaatcaatg gagctgccga caagcttttt 671101 aatcatatct tttttgttgt catctgcgat gcccaccggc gtaatgccga gattgtgaac 671161 ggcatccaag aatgaaagct caagcacaac cacccgctta ggtgtgccgc ttactgtcgt 671221 ttttccttct tcgtcatgga tcactctgga atccttagac tcgcttttgc cgcttccgtt 671281 gttattctgg cttgatgaac agccggatac aatgaggcag gcgagcaata aaacactcat 671341 gatggcaatc aacttgttag aataggtgcg catgtcattc ttcctttttt cagatttagt 671401 aatgagaatc attatcacat gtaacactat aatagcatgg cttatcatgt caatattttt 671461 ttagtaaaga aagctgcgtt tttactgctt tctcatgaaa gcatcatcag acacaaataa 671521 gtggtatgca gcgttaccgt gtcttcgaga caaaaacgca tgggcgttgg ctttagaggt 671581 ttcgaacata tcagcagtga cataaggaag gagagtgctg agataaccgg acaatttctt 671641 ttctatttca tctgttagtg caaattcaat gtcgccgata ttcatgataa tcgagaaaac 671701 aaagtcgata tcgatatgaa aatgttcctc ggcaaaaacc gcaagctcgt gaattcctgg 671761 tgaacatccg gcacgcttat ggaaaatctg tttgactaaa tcactcacaa tccaagcatt 671821 gtattgctgt tctggtgaaa agtattgcat tagacatacc tcctgctcgt acggataaag 671881 gcagcgtttc atggtcgtgt gctccgtgca gcggcttctc cttaattttg atttttctga 671941 aaataggtcc cgttcctatc actttaccat ggacggaaaa caaatagcta ctaccattcc 672001 tcctgttttt ctcttcaatg ttctggaatc tgtttcaggt acagacgatc gggtatgaaa 672061 gaaatataga aaacatgaag gaggaatatc gacatgaaac cagttgtaaa agagtataca 672121 aatgacgaac agctcatgaa agatgtagag gaattgcaga aaatgggtgt tgcgaaagag 672181 gatgtatacg tcttagctca cgacgatgac agaacggaac gcctggctga caacacgaac 672241 gccaacacga tcggagccaa agaaacaggt ttcaagcacg cggtgggaaa tatcttcaat 672301 aaaaaaggag acgagctccg caataaaatt cacgaaatcg gtttttctga agatgaagcc 672361 gctcaatttg aaaaacgctt agatgaagga aaagtgcttc tctttgtgac agataacgaa 672421 aaagtgaaag cttgggcata aagcaaggaa aaaaccaaaa ggccaatgtc ggccttttgg 672481 tttttttgcg gtctttgcgg tgggattttg cagaatgccg caataggata gcggaacatt 672541 ttcggttctg aatgtccctc aatttgctat tatatttttg tgataaattg gaataaaatc 672601 tcacaaaata gaaaatgggg gtacatagtg gatgaaaaaa gtgatgttag ctacggcttt 672661 gtttttagga ttgactccag ctggcgcgaa cgcagctgat ttaggccacc agacgttggg 672721 atccaatgat ggctggggcg cgtactcgac cggcacgaca ggcggatcaa aagcatcctc 672781 ctcaaatgtg tataccgtca gcaacagaaa ccagcttgtc tcggcattag ggaaggaaac 672841 gaacacaacg ccaaaaatca tttatatcaa gggaacgatt gacatgaacg tggatgacaa 672901 tctgaagccg cttggcctaa atgactataa agatccggag tatgatttgg acaaatattt 672961 gaaagcctat gatcctagca catggggcaa aaaagagccg tcgggaacac aagaagaagc 673021 gagagcacgc tctcagaaaa accaaaaagc acgggtcatg gtggatatcc ctgcaaacac 673081 gacgatcgtc ggttcaggga ctaacgctaa agtcgtggga ggaaacttcc aaatcaagag 673141 tgataacgtc attattcgca acattgaatt ccaggatgcc tatgactatt ttccgcaatg 673201 ggatccgact gacggaagct cagggaactg gaactcacaa tacgacaaca tcacgataaa 673261 cggcggcaca cacatctgga ttgatcactg tacatttaat gacggttcgc gtccggacag 673321 cacatcaccg aaatattatg gaagaaaata tcagcaccat gacggccaaa cggatgcttc 673381 caacggtgct aactatatca cgatgtccta caactattat cacgatcatg ataaaagctc 673441 cattttcgga tcaagtgaca gcaaaacctc cgatgacggc aaattaaaaa ttacgctgca 673501 tcataaccgc tataaaaata ttgtccagcg cgcgccgaga gtccgcttcg ggcaagtgca 673561 cgtatacaac aactattatg aaggaagcac aagctcttca agttatcctt ttagctatgc 673621 atggggaatc ggaaagtcat ctaaaatcta tgcccaaaac aatgtcattg acgtaccggg 673681 actgtcagct gctaaaacga tcagcgtatt cagcggggga acggctttat atgactccgg 673741 cacgttgctg aacggcacac agatcaacgc atcggctgca aacgggctga gctcttctgt 673801 cggctggacg ccgtctctgc atggatcgat tgatgcttct gctaatgtga aatcaaatgt 673861 tataaatcaa gcgggtgcgg gtaaattaaa ttaagaaagt gaaaaacaca aagggtgcta 673921 acctttgtgt tttttaatta attaaaatgt ttattaactt agttaaggag tagaatggaa 673981 aaggggatcg gaaaacaagt atataggagg agacctattt atggcttcag aaaaagacgc 674041 aggaaaacag tcagcagtaa agcttgttcc attgcttatt actgtcgctg tgggactaat 674101 catctggttt attcccgctc cgtccggact tgaacctaaa gcttggcatt tgtttgcgat 674161 ttttgtcgca acaattatcg gctttatctc caagcccttg ccaatgggtg caattgcaat 674221 ttttgcattg gcggttactg cactaactgg aacactatca attgaggata cattaagcgg 674281 attcgggaat aagaccattt ggcttatcgt tatcgcattc tttatttccc ggggatttat 674341 caaaaccggt ctcggtgcga gaatttcgta tgtattcgtt cagaaattcg gaaaaaaaac 674401 ccttggactt tcttattcac tgctattcag tgatttaata ctttcacctg ctattccaag 674461 taatacggcg cgtgcaggag gcattatatt tcctattatc agatcattat ccgaaacatt 674521 cggatcaagc ccggcaaatg gaacagagag aaaaatcggt gcattcttat taaaaaccgg 674581 ttttcagggg aatctgatca catctgctat gttcctgaca gcgatggcgg cgaacccgct 674641 gattgccaag ctggcccatg atgtcgcagg ggtggactta acatggacaa gctgggcaat 674701 tgccgcgatt gtaccgggac ttgtaagctt aatcatcacg ccgcttgtga tttacaaact 674761 gtatccgccg gaaatcaaag aaacaccgga tgcggcgaaa atcgcaacag aaaaactgaa 674821 agaaatggga ccgttcaaaa aatcggagct ttccatggtt atcgtgtttc ttttggtgct 674881 tgtgctgtgg atttttggcg gcagcttcaa catcgacgct accacaaccg cattgatcgg 674941 tttggccgtt ctcttattat cacaagttct gacttgggat gatatcaaga aagaacaggg 675001 cgcttgggat acgctcactt ggtttgcggc gcttgtcatg ctcgccaact tcttgaatga 675061 attaggcatg gtgtcttggt tcagtaatgc catgaaatca tccgtatcag ggttctcttg 675121 gattgtggca ttcatcattt taattgttgt gtattattac tctcactatt tctttgcaag 675181 tgcgacagcc cacatcagtg cgatgtattc agcatttttg gctgtcgtcg tggcagcggg 675241 cgcaccgccg cttttagcag cgctgagcct cgcgttcatc agcaacctgt tcgggtcaac 675301 gactcactac ggttctggag cggctccggt cttcttcgga gcaggctaca tcccgcaagg 675361 caaatggtgg tccatcggat ttatcctgtc gattgttcat atcatcgtat ggcttgtgat 675421 cggcggatta tggtggaaag tactaggaat atggtagaaa gaaaaaggca gacgcggtct 675481 gccttttttt attttcactc cttcgtaaga aaatggattt tgaaaaatga gaaaattccc 675541 tgtgaaaaat ggtatgatct aggtagaaag gacggctggt gctgtggtga aaaagcggtt 675601 ccatttttcc ctgcaaacaa aaataatggg gctgattgcg gctctgctgg tctttgtcat 675661 tggtgtgctg accattacgt tagccgttca gcatacacag ggagaacgga gacaggcaga 675721 gcagctggcg gttcaaacgg cgagaaccat ttcctatatg ccgccggtta aagagctcat 675781 tgagagaaaa gacggacatg cggctcagac gcaagaggtc attgaacaaa tgaaagaaca 675841 gactggtgcg tttgccattt atgttttgaa cgaaaaagga gacattcgca gcgcctctgg 675901 aaaaagcgga ttaaagaaac tggagcgcag cagagaaatt ttgtttggcg gttcgcatgt 675961 ttctgaaaca aaagcggatg gacgaagagt gatcagaggg agcgcgccga ttataaaaga 676021 acagaaggga tacagccaag tgatcggcag cgtgtctgtt gattttctgc aaacggagac 676081 agagcaaagc atcaaaaagc atttgagaaa tttgagtgtg attgctgtgc ttgtactgct 676141 gctcggattt attggcgccg ccgtgctggc gaaaagcatc agaaaggata cgctcgggct 676201 tgaaccgcat gagatcgcgg ctctatatcg tgagaggaac gcaatgcttt tcgcgattcg 676261 agaagggatt attgccacca atcgtgaagg cgtcgtcacc atgatgaacg tatcggcggc 676321 cgagatgctg aagctgcccg agcctgtgat ccatcttcct atagatgacg tcatgccggg 676381 agcagggctg atgtctgtgc ttgaaaaagg agaaatgctg ccgaaccagg aagtaagcgt 676441 caacgatcaa gtgtttatta tcaatacgaa agtgatgaat caaggcgggc aggcgtatgg 676501 gattgtcgtc agcttcaggg agaaaacaga gctgaagaag ctgatcgaca cattgacaga 676561 ggttcgcaaa tattcagagg atctcagggc gcagactcat gaattttcaa ataagcttta 676621 tgcgatttta gggctgcttg agcttgggga gtatgatgaa gccattgatc tgattaaaga 676681 ggaatatgcg atacaaaatg aacagcatga tcttttattc cataacatcc attcgcagca 676741 ggtgcaggcc attttgttag ggaaaataag caaggcatcg gaaaagaagg tcaagctggt 676801 gattgatgag aacagctcac tcgcgcctct tcctgcgcat atcggcttgt cccatcttat 676861 tacgattatt ggcaatttaa ttgataacgc tttcgaagct gtagcggagc aaagcgtgaa 676921 ggaagttttg ttttttatca cggatatggg ccatgacatt gtcattgaag tatcagacac 676981 agggcccggt gtgccgccag agaaaataga agctgtgttt gagagaggct attcttcaaa 677041 ggggatgagg agaggctacg gtctggccaa tgtgaaagac tcagtgcgtg aactgggcgg 677101 ctggatcgaa ctggcgaatc aaaaaactgg cggggcggta ttcactgtat ttataccgaa 677161 ggagaaacaa agggggaatc catttgattc acatcgcgat tgcggaggat gattttcgag 677221 ttgcgcaaat ccatgagaga ttgattaaac agcttgatgg attcaagatt atcggcaagg 677281 cggctaacgc aaaagagaca ttggcgcttt tgaaggaaca caaggctgat ttgcttctgc 677341 tggatattta tatgccggac gagcttggga ccgcgttgat tcctgatata cgaagccgat 677401 ttcctgaagt ggacattatg attatcacag cggcaacaga aacccgtcat ttgcaggaag 677461 cgctaagggc gggaattgcc cactatttga tcaaacccgt aacagctgac aagttcaggc 677521 aggtgctgct tcagtataaa gaaaaaagga agctgctcat gtctcagccg gaggtcagcc 677581 aatccatgat cgaccatatt tttgggaacg gtgtgaagac agctttgccg gcagaggatt 677641 tgccgactgg cattaattcg attacactgc gaaaaattaa ggaagcgctt cagactgcgt 677701 cagaaggatt gacagcggag gaacttgggg aaaaaatggg ggcgtcacga acaactgccc 677761 gccgttatgc cgagtacctt gtgtcaaagg aagaagcaag agccgagctt gaatacggga 677821 ttatcggcag gccggagaga aaatattatt tggcggcgga ttagatatga aaaaatctat 677881 aatcctattg aatattctat tgatctttat gcagggtgat atcaggcagg cggctgcgcc 677941 gcgcctgccg gacgggccga tagaaattgt cgtccctgcc gaaccttctg gcggctggga 678001 tgtcacagcg caggcgatcc aatcagtttt gaggcagaag cagatcgtga aggatgatgt 678061 tcatatcgtc tataaatccg gcggcggggg agagaaaggc tggaaatatg tcaacaaaag 678121 cagcaaacaa accatcagca tgacgtccag cctaatattg agcaatgatc ttctcgggca 678181 aagcaaatta aaaatgtccg attttacgcc gctcgccatt ctctccaagg aatggcagac 678241 ggttgcattg ccaaaaggat cagcgttaac aaatggcaag gatgtgctga atgagatcaa 678301 catgcatccc ggcaaggtga gaatcggctt tgccccgggg tttggcaatg atgatcagct 678361 ctcgttcgtc agagcggcag atatgtacgg cattgacccg tttgacattc aattctcaca 678421 gtatgacagc agcgaacagc tcattcaggc gctgatcaga catgagatag aagcggcttc 678481 catgacactt tctgaagcga aaccatatga acgaaacggc gatatcacgt tagccgctgt 678541 aacgtctgat aaaagacttc ccggttttcc aaatgtaccg acgtggaagg agcagggaat 678601 cccgtttgtt ttttctcatt ggagagggat tttgggcccg aaaaatatgt ctgaggaaga 678661 gatttcttac tgggatcaag cgctaaagaa ggtcacctcc tcacctgaat ggaagcggaa 678721 aataaacgaa caggactggg aaagctttta tttaaacagc agggaaacga aacggttttt 678781 agaagagcaa tctgcttttt atcaaagcat catgacagga aattaaaatc ccgacatccc 678841 gggatttttt tcatgccgaa aattgatcaa aaagaacaaa acggttttaa aaaattaaaa 678901 atacaaaaaa accaaattat ttacttgcgg ttggttttcc catacgatgg caaaaaggca 678961 agacaaaaag gggagtaagg gagaaaaaaa tgtaagcgga ttcatttaag ggggaatgga 679021 tgtgttagca atcttaggct ttctcatgat gcttgtgttt atggcattga tcatgacaaa 679081 acggctttct gttttaacag cattagtttt gacgccgatt gtgtttgcgc ttatcgccgg 679141 atttggattt actgaagttg gggacatgat gatttcgggg attcagcaag tcgcgccgac 679201 tgcggtcatg attatgtttg cgatcttata ttttggaatt atgattgata caggcctgtt 679261 tgatccaatg gttggcaaaa ttttaagcat ggtcaaagga gaccctttaa aaattgttgt 679321 cgggacagcg gttcttacaa tgctcgtcgc cttggacgga gatggctcga caacgtacat 679381 gattacgaca agcgccatgc ttccgctcta tttgctgcta ggcatccggc caattatctt 679441 ggcaggaatc gcgggagtcg gcatgggaat catgaacacg attccatggg gaggtgcgac 679501 gccgagggcg gcgagtgcgc tgggggttga tccagctgag cttacagggc cgatgattcc 679561 tgtcattgca agcgggatgc tttgtatggt ggcagttgcg tatgtgcttg gaaaagcgga 679621 acgaaagcgc cttggtgtga ttgaactgaa acagccagcc aatgccaatg aaccggctgc 679681 tgcggttgaa gatgagtgga agcggccgaa gctttggtgg ttcaatttat tgttaacgct 679741 ttctttaata ggatgtttag tatcgggtaa agtcagttta accgtactgt ttgtcattgc 679801 gttttgtatt gcgctgattg tgaattatcc caatctcgag catcagagac agcgcatcgc 679861 ggcgcattcc agcaacgtgc tggctatcgg ttcaatgatt tttgctgcgg gggtgttcac 679921 ggggattttg acaggcacga aaatggttga tgaaatggcg atctcgctcg tgtccatgat 679981 accggaacaa atgggcggat tgatcccggc gattgttgcc ttaacaagcg gcattttcac 680041 atttttgatg ccgaatgacg cgtatttcta cggggtgctg ccgattttat cagaaacagc 680101 tgtcgcatac ggtgtggata aagtggaaat tgccagagcc tctattatcg gccagccgat 680161 tcatatgctg agtccgcttg tgccatccac tcatttgctt gtcggactcg tcggagtttc 680221 tattgatgac catcaaaaat tcgcattgaa atgggcggtt ctcgcagtga tcgtcatgac 680281 ggctatcgct ctattgatcg gtgcgatctc tatttccgta tgataattca ggcgtaatga 680341 cacacactaa cggcatacaa cattccggag gtgtcattat gagtgatcct tatatgccgc 680401 tgacttcagt cagaagcgga gcggggttcg aagcggcaaa aggggtgcac ggcctgactg 680461 tgcaaattgc gaatgtctat tttattcagc tgccttctga acctcactca tttgttttaa 680521 ttgatgccgg catgccccaa tcagccggcg tgattgtcaa tgaagccaaa caaagattcg 680581 gtgaagggtt tcagctgaag gcgattatcc tcacacacgg gcactttgac catattgggg 680641 caatcgaaga gatccttgag cattgggatg tgcctgttta tatccattct cgggaaatgc 680701 cttatgtaac aggtaaagag gattatcctc cggctcgtcc tgacagcaag agcgggctgg 680761 tcgctaagct gtcgccgctg tttccgcggc actctatcga tatttcctca catgtccagg 680821 cactgccgga agacggttca gttccttttc ttgacgagtg gatgtggatc gcgacaccag 680881 gacacacgcc gggccatatt tcgttattcc gcgatgacgg ccgcgtgctt gtggcaggtg 680941 atgctgttat tacagtggaa caggagaaaa tggctgacgt cttgatacaa aaacaggagc 681001 ttcacgggcc gccggcttat ttcacgcctg acacagagac ggccgctgag tccattctaa 681061 agctggccgg tcttgaaccg gaagcgttat tgaccgggca cggcataccg atgaccggca 681121 aaaactttcg aagtgactta actgaattgg caaatcggtt atcgtctatt tgacacccgc 681181 accacgcggg tgttttttat tgttttccag gaagttgcag aaaaatcatt tgtcttgccg 681241 cttaaaaacg atacaatgaa aagcatgaag tgatgtgaag gggagagttt gttggaagaa 681301 aaagaaatac tctggaacga agcgaaagcg tttattgccg catgctatca ggaattggga 681361 aaggaggagg aagtgaaaga ccgtctcgcg gacattaaaa gtgaaattga cctgaccgga 681421 agctatgtac atacgaagga agagctggag cacggagcga aaatggcttg gagaaacagc 681481 aaccgctgca tcggcagatt gttctggaat tcgctgaatg ttatcgacag acgagacgtc 681541 cggacgaagg aggaagtgcg tgatgccctc tttcaccata ttgaaaccgc caccaataac 681601 gggaaaatca gaccgaccat tacgattttc cctccggaag agaagggtga aaagcaagtc 681661 gagatctgga atcatcagct gatccggtac gctggatatg agtcagacgg agaaagaatc 681721 ggcgacccgg cttcctgttc cctgacagca gcctgcgaag agctcggctg gcgcggagag 681781 cgaacggatt ttgacctgct gccgctcatt tttcgcatga aaggggacga gcagcctgtc 681841 tggtatgagc tgccgcgttc acttgtgatt gaggttccaa tcacacatcc ggacatcgag 681901 gcgttttctg atttggagct gaagtggtac ggcgtgccta ttatttctga tatgaagctt 681961 gaggtcgggg gcattcatta taatgccgcg ccatttaacg gctggtatat gggcacggag 682021 atcggagcga gaaacctcgc agatgaaaag cggtacgaca agctcaaaaa agtagcgtcc 682081 gtgatcggca tcgccgctga ttacaatacg gatttatgga aggatcaagc gctagttgaa 682141 ttgaataaag ctgtgctgca ctcgtataaa aagcagggtg tcagcatcgt tgaccatcat 682201 acagcggcaa gccagtttaa acggtttgaa gaacaggagg aagaagcggg cagaaagctg 682261 acgggggact ggacgtggct gattccgcca atttcacccg ctgccactca tatcttccac 682321 cgctcctatg ataactcaat cgttaagccg aactattttt atcaagataa gccttatgag 682381 taaacaatag aaaatcgatg atggccttca aggctgcggg attcagtcac agagatgtcg 682441 gtaacctttg agaaagggct tccgttcttt acagcctcaa caaacgattg cagggcgttt 682501 tccggaccct ctgccaaaat ctcgacacgc ccgtcatcac ggtttttgac ccagccggcc 682561 agttttcgct tatcagcttc catttgaaca aaatagcgaa agcccacacc ttgaacccgg 682621 ccgtctacaa tgattcggta ttgaagcatg taaaaaccac cttttctttt tatgataatc 682681 aatcatttta caacctgtaa aggggatgtg tttgtatgaa acaagagcgc tattcagttc 682741 tttctcttaa tctgggaaaa ccgcagacgc ttgaatatga cggaaagaaa atcgaaaccg 682801 gcatcatgaa gcggccggct aaatcagccg tcatgctgta tcgggagaat tttgaaggag 682861 acggacaggc ggacctcgtc aaccacggcg gacctgataa ggctgtctgt gtctacccgg 682921 cggagcatta tccgttttgg gaagagttcc tctcaagacc gctgtcaaat gccgcatttg 682981 gagaaaatct gacggtcgcg ggcctgactg aggagaatgt ttgcatcggg gatgtgttca 683041 gacttgatga agctgttgtt caggtcagcc agccgcgcca gccgtgtgta aagctggcga 683101 aaaagtttgg tgtaaaagaa atggtgctga aggtccagca aaccggctat acagggtttt 683161 attttcgcgt gctggaggag ggcagggtgt ctcccggcgc gaaccttgaa ttgctgtcca 683221 gaggagagaa aggcatatcc gtccagttcg cgaaccgcat caactaccat gatgcaaaaa 683281 atctcaccgc cattgaacgg attttaagtg aggctgcact atcggaaagc tggagagcgt 683341 cctttatgaa aaaaaaggac aggctgctgc cggttgaata gaaaaaagcc gcgcatatca 683401 acgtgcgcgg ctttgccata tttaagattg ttttttcttt gattcaagca ggttggcaag 683461 aaaataggtt ttatagcttt gaagctttct tccttcatgg tgcgtgatcc cctgcttttt 683521 tagttctgcc acataccagc ctttactgcc gtaatgcatg tcagaaaact cctttcccta 683581 tctgatttcg aaacgattgg cattgtaaca tctataaaaa gatgctgaaa agagatgcgg 683641 ggaaaactga gcctttcgca ctagatgtac gaatgttctt ctgaatgtat atgcggagca 683701 aaagccgaat atgatttaat ggccggttag tttgatcatg acaacgccaa atgtcataat 683761 ggcgaaaaca atgccgatat atgtgagcat cccgtttttt ttcttaacgc cgtaaacggt 683821 cataatgatg ccttcaatga aaaaaatgat gccgaaaata ataaaccaca tgcagataaa 683881 ggctcctttc acagacataa tagtagtgta gcatatctga aagagccggg ctgtgacaat 683941 atcaagaaag ccgggcgcat atcgcccggc tcatgtttta ttgtttatca accaatttga 684001 ccagaagctg tgccaaatgt tctttctcat cttcgtctgc aacgctccaa agctcttgca 684061 gcagcatttc ttcaccgttt tgcggctctt catgctttgc gaggtagtct cccaggatcg 684121 cagcgctttt tacaagcttg ccgtcatcca atcccagctt tttgcctcgg ttgacttgtt 684181 ttttcaggta gcctttaaat tcctcaaagt cttttaaaat gtcttctttt attgtgccat 684241 gcatcgcgtt catttcgttt tcaatttgga ttttttcttg atctctgttc attgcaagac 684301 ctcctcgtac agaataatga tgctttacct gcaattggag gaggttaaac ctgccggaag 684361 cccggaatgt gttttacagt ttcgtcagga taatcggttc atcttttgtg atgacgatcg 684421 tgtgttcaac ttgggcaacc atgcttttat ccggcgtctt gaacgtccag ccgtctccag 684481 cttcaacaat cgtttctgct ttcgttgaaa taaacggttc aagcgcgatg actgtgccat 684541 ttttgaacag cgcattatca aacggatcat aatagttcat gatgtggttc ggcgcttcat 684601 gcaggcttcg gccgattccg tggccggtca gggttttgat gacggtaaag ccttgagagc 684661 gtgcttcatg ataaacggct cttccgatct ggttttggcg cttgcccgct tttgcctgct 684721 gaagcccctt ttgaaaagcg ttttccgcgc attggcaaag cttatgaagg cgttcttctc 684781 cttcaccgag cacaaatgag atgcctgtgt cggaatagaa gccgccaaat tcagcggaga 684841 tgtcgatgtt gacaaggtcc cctgctttta aaattttgga tgtgcttggt atgccgtgag 684901 ccacttcatc atttacgctg atacatgtca cacctggaaa atcgtattcc ttctcaggag 684961 ctgaaacggc gccgtgctca tcaagcacag cttttccgat aaggtcaagg tcttttgtgc 685021 tcatgccggg ctctgccttc cgcttcattt cttcacgcgc aagcgcgacg attcttccga 685081 tttttttcag gccttctaat tcttgatcgt ttgttacaat catctgtcat tcccgctttc 685141 tttttaaata atctagatta agcttaccac aactgtctta aaaataggaa acacacggac 685201 ctgggaaaaa agaaataccc ccgggaaaat tggtatagat cactagatat cttatatggt 685261 atatttgaaa aaaaagggta tgagggggat gggtatgctt tcatttttac aaaaactcgg 685321 gaagtcattt atgctcccga ttgcggttct gcctgcggtt ggaattatcc ttgcgcttgg 685381 cagagaggat gtatttaata tcccgtttgt ctatcaggcg gggacggcgg tttttgatca 685441 tctgccgctt atttttgcga tcggtattgc catcggcatt tcaaaagaca gcaatggggc 685501 agcgggttta tcaggggcga tatcgtatct gatgcttgac gcggcaacaa agacaattga 685561 taaaacaaat aacatggcgg tgtttggggg aattattgcc ggtttaattg ccggttacac 685621 ctataaccgc ttcaaggata ccaagctgcc tgaatatctc gggttcttca gtggcagacg 685681 gcttgtgccg attttaacag ccattattac gatcatttta gcgggcatat tcggagtggt 685741 ctggccgccg attcaatcgt gtatcaactc gtttggagag tggatgctcg ggctcggcgg 685801 catcggggca ggcatattcg gcctattcaa caggctgtta attccgcttg gccttcacca 685861 tgtgctgaac aatattttct ggttccaatt cggagaatat aacggagtga caggggattt 685921 ggcgcgcttt ttcgcgaaag atccgactgc gggcacatat atgaccggat ttttcccaat 685981 catgatgttc ggtcttccgg cggcgtgtct ggctatggtt gtgactgcga agccgtctaa 686041 acggaaagcg acggctggaa tgatgattgg atttgcttta acggcgttta tcacagggat 686101 tacggagccg attgagtttg catttatgtt tttatctccg cttttatacg ctgttcacgc 686161 ggtcttaacc gggttatctt tatttatcgt caactggctc ggcatccgct caggcttctc 686221 tttttcagcc ggagctatcg attatgtgct cagctatgga atcgcggaaa aaccgctgct 686281 tctgcttttg gtaggtatat gctatgcggc agtatacttt atcgtgtttt atgtactgat 686341 taaggctttg aatttaaaaa cgcctggacg ggaagacgat gatgtggatg aagtgctgga 686401 tgaaaatact gttcaggatg taaatgaaaa catcatgctg aaagggctcg gcggaaaaga 686461 aaaccttcaa accattgatc attgcgccac aaggctgcga ctgactgtga aggataccgc 686521 tttggtggat gaagcactgc taaagaaagc aggcgcaaaa ggggttgtca aatcgggcgg 686581 gcaatcggtt caagtcatta ttggcccgaa tgtggaattt gcagctgagg aattgagggc 686641 tgctgtcaaa taaaaaagcg gagagggcaa cctctccgct ttttcttatt tatcttcgtt 686701 atcctttgac gtttcggaag aatcttcgtc atgttttgtg taatcataat cagaaggatt 686761 caccttctta aaacctttcg gctcgtagaa ccgcagcagg tctccgttta tgattttatc 686821 ggacatttca agttccttct tgacgagtga gtcttctgac ttgtcgactt cggattcatc 686881 gagttctttt ccggttttcg tgtcgtaata cttaccggat attttcgtgt acttcggtga 686941 aataaagtct ccgtttcgga acggaatcac ttcacggtgt tctttcgata aaatatcaga 687001 accggacatc agatagtcct tcgtatccac tccgagcaga tgcagaatgg taggagccac 687061 atcaacgtct ccggcatatt tatgaacttt ctcgcccttc acgccggcag cgtggataaa 687121 gagcggcacc cgttgaagct gggcgttgtc gtaatcagtg atttcatcct tgccaagcac 687181 tttcgccatc gctttattgt ggttttcaga gatgccgtag tggtctccgt acatcacaat 687241 aatcgattta tcatataacc cgtctttttt cagatcattg aagaattgtt caatggactg 687301 atcaaggtaa tgggctgact ggaaatagtt atcgacgaca gagtcaccaa agtctccagc 687361 cgggaagtct gtatccccct catccattcc gaatgggaag tggttggaaa gggtaatgaa 687421 cttcgtatag aacggctgcg gcaggctttc cagcagcggc attgattctt tgaagaacgg 687481 tttgtctttc atgccgtagt ttttcgtgtt ttcttcgttc atgtcatagt aagcagaatc 687541 aaagaattta tcaatgcctt ccgccttgta catttcgtta cggttccaga acgtctgcgt 687601 gttcccgtgg aaagtagcag atgtgtaatt cttagacttc agaatcgccg gaacggattg 687661 cagcgtgttt tgcgctttgt ttacgaaaac tgaaccttga gccagcgggt acagagagtt 687721 ttccatcata aattcagcat cagatgtttt accttgtccc gtttggtgga aaaagttatc 687781 aaagtagaac gtttcgttat catgtgccag tttatttaag aatggtgtca cttctttgcc 687841 gtcaatttta tagtcgatga taaatgactg caaagattca agtgaaacgt aaatgacgtt 687901 ttttccttcc gctttgccga aatacacgtt attcggcaca tcgtaattgg ctttcatgta 687961 gttttctact tccgttacgt cgctggaatc ggcaagcgcg cgctggctgt tggacttgat 688021 attctgtaca gcgtcataaa tcgtgaaatt gtatgttccc aagtatttca caagatagtt 688081 ccggtcgaat gatcttgtca gcaattcagg acggtctgat tccgcaactg ccaggttgat 688141 caagaacaca agaattgaag acgcaaaaat aattcggaac gattttttgc ttgacgtttc 688201 ggcaggcttg tttactttga tcgccaagat gatcaggatg atcgtatcga taaagtaaaa 688261 ggcgtcagtc ggtctcatca gcgaaaatgc gctgtcaccg agttggccgc cgtttgtttt 688321 agcctgcata atgaccggaa ttgtaataaa atcattgaaa aatctgtagt acacaatgtt 688381 ggcgtacagt aaaaaagaca ttaaaaaatg aatcactata atggctgtct gctgtaattt 688441 tttcttgaac aagagtccaa agccaagaaa gaacaagctt gagctaagag gattcacaaa 688501 aagcaatatt ttttgtatcg tgttgtctat tcctaagttg aaattcagga cataaccgac 688561 atacgttttg atccataaca ggacgaccgc aattaagaag aaggccagtc ctctttcttt 688621 tataaatgtt ttcattgtta cactcctttt ttccgatcca gttcgagcga aacgatagaa 688681 aaaacgaacg tatccaatat aacacgaatc agcagattag aaaagtgaaa atcgtatgag 688741 ggagaaagtg gcgaaaaacg ccgtcgaatc aacgtttcgc tttgatatta ccaaatgtaa 688801 aacaaggtat ctttctagaa ataaaggaat aaaatggtac attgagaatt gtatgataaa 688861 atataaggta tagataaaaa gaggtgaaat gatggatttt tcccatattg tgtctgaaga 688921 taaaattaag cgcgccatca aagacgggga ctttcaaaac ctcccgggaa tggggaagcc 688981 gctgccgaag gatgacgcgg cacacttgcc ggaatcgctg cgcatgggct atcgtatttt 689041 gaaaaacgcg ggaatggcag aggacgaggg cgcgctcaaa aaagagctta tgaccatcga 689101 ccatttaatc gaaaagtgct atgacgaaaa agaacgcgag caattaatca gaaaaaaatc 689161 tgaaaagcaa ttgctgcttg ataagcttgt cgacaaaaaa ggcatgtttt caaagccagc 689221 atccgctttt tataagaata aagtatatga ccggcttgga cgaaacagac cttcttccag 689281 ctgatttgtc ttgtctgcag gatggcgatt gataaaagcc atccttttta tgttccaagt 689341 tctatgtcaa aaggtttatg tttttccatc tatgggaaat gattcataaa cgaaaaaagg 689401 gtgatgggat ggaacgacta ttagtatgga tagagcatat atctgattgg ctgtggggtc 689461 cgccgctaat catcctgctg acggggacgg gcttgtattt cactattttg ctgaaaggtt 689521 ttcaatttcg ctatccttta tacattttca aacagacaat cggcagtgta ggaaaaaagc 689581 cgaagggaga aggcacagtc acaccgcttc aggcattgac ctcagccctc agttcaacga 689641 tcggtgcagc gaacattgtc ggtgtgcccg ccgctattat gtttggggga ccaggagcgg 689701 ttttttggat gtggcttatt gccttatttg ccatggcgat taagttttct gaaagtgttc 689761 ttgctgttca ttacagagaa aaaaatgagc agggtgaata cgtcggggga ccgatgtatt 689821 acataacaaa agggctgcgc atgaaatggc tcggcgtatt cttctctgtt gcgctgattg 689881 tggagctgat tcccagcatt atggttcagg gaaattcggt ttcagtctcg cttgccgaga 689941 cgttttcttt caataaaata tacgcaggaa tcggaattgc atttttgatt gggttagtgg 690001 tgataggagg ggtaaagcgg atcggaaaag taacagagtt tgtcgtgcct cttatggcag 690061 gggcatacgc aggtgccggt ctcctgattg ttctcatgaa tctatcatca gtgccggcgt 690121 ttttctctct cgttttttca aatgcgttta cctcttcttc agcagttgga gggttcgcag 690181 gtgctgcgtt ggcggaaacc gttcgctggg gatttgcccg cgggctgtat tctaatgaag 690241 ccgggatggg aacagccccg attgcacatg cggcagcaat gactgatcat cctgtgcggc 690301 aagggttttg gtctgtgatc ggcattgtca ttgacacctt aatcatctgt acgactaccg 690361 cttttatcgt ccttgcatcc ggtgtatgga cagggaagaa cgcctcaaat gacccggcag 690421 cactgacaac ggccgcattt cagcactatt tcggttctgg aggaggatac ttcgtttcgg 690481 tttccctggt cttctttgtc gtatcaacca ttatggttgt cattttttac ggcgtaaagc 690541 aagctgaatt tctgttcggg cggctggcag gacatgtgat taaattcgtt tatttagcgg 690601 ctattatcat aggtgccgca ggcggagcaa aagccatttg gggcgtattg gacttagcat 690661 tggtttttat tgttgtcccg aatgtgattg cgctcttgtt attgagcaga aaggtaaaag 690721 cgctgtacac cgaattcttt acatctgaac agtactacct gaaagatata agaaaaacga 690781 aacaaaagcc tgtttatcca acaaaagaag ctaaaaattc ctagtgtttt gcttttgcgc 690841 cgaacaatgc tttgcttttt atgatcaaat aaatgagtaa aggcagcaaa agagaaatca 690901 ctacattaat gattggtttg attctgttaa agtcgattag ctgatttgta tttaaaaaaa 690961 accaaaagcc gcatacgact gagaacatgc cggttggtgt atacatggct ttcgggtcga 691021 tttttgagtg taaaaacgaa aggccgtata ccacgatata tagggaacct gctatcttca 691081 ccataatgac cggaatccaa aaagccgcga tgatcaggtc tgagcgatcc agaaaatccg 691141 taatgcggat ctgcctgatg accatataag caggatcaaa gaaagtagat gtcaggttgg 691201 gaccaaagac agaaattgaa gaaaataaca tcacggccag caataaagcg cccagcagta 691261 tcgcgaaaat ggtgtatttt agcgggacgc tccggtttga gaagagaagc ggaaggataa 691321 tcaattcccc cattgtccca aacgcgtaat agcctgattg aaggtatggg attagacctt 691381 caaaaacagg tgtcaagttt tgaagctcaa tttgtgtggc cagcgtaaat ggaaggaaca 691441 agaccaggat gccgaatgga aataggaata tctgcgccat tctggtcaat gtttcttttc 691501 cctctctggc aatacagatc gccacaaaga taataacacc gccaagaaca gccattggtg 691561 ttctcgggag aaataaaatg ttaatcaaat tgatgaaaaa acgtatatca tgagcattga 691621 ttaacaggaa atacaaagaa aacagtaaaa tgataatccg gcctgcgatt ggtgaggaat 691681 cgctcagcag ctcatagata tttttatcct gatgcttttt catcagccta tgcatgagcc 691741 agagtgccgg aatcacgatg acaacgccga ggatgtagct gtgccaggca ttttgttttg 691801 ctgattcgat catgagaatc ggagcatgct ttaatccgac tgctaacgta tacagagctc 691861 cgaaaaataa tccttggtat gcagaggtct tgtccataaa gcacatcctt tctgtcatgt 691921 tcaaaacgga atatatttaa acaggtgccc cagccgcgga agcaggggat tcactctcat 691981 ataaatccat agaaaagcac ttcctgcaat tagcaggctg aaggcccatt ttgttagatt 692041 gttagcggaa cgaaaattct tccattcata tgcgtatatg gcaatgcaca caatcaatgt 692101 ctgtacgata tagctgatca tgctgacgca cctccattaa tggctgatcg ttttgtatag 692161 gacaccgccc tgctcaatcg tcacaattgg gacgacgtga acctccatat ccttatatac 692221 ctcttcccat tcctttttca gcagattctt cgtggttgcc gtgcttctga tggtcctgtc 692281 ttgaaagccg gccgggtccg cctttagctt ttgcaaacga tgaacggtgc tgatcacgtc 692341 cttctttatg gttctgttta atgctttttg aatgatgtaa tactggtcat tttctctcgt 692401 ctcataggtt gattggtttt ccataataat tcctttggct ctgatctcga ttgtcattga 692461 cagctttccg tttttttcag cggcatgaaa ggatgcattg gacttttgaa gctgaatgga 692521 tgcttgcccc atttgattcg gcaggtctac tatgaattct ggctggcggg cttgattcag 692581 caacatcagg gctgctgtca tgtgttcatc tttgaaaata tccatcaatc tgtccttttt 692641 aaagatcgca agcccgtcaa ttttcaaatt agatttgcct ttccctccag gttttgtttt 692701 agatgcagag atgaccggtg catacggatc actgcctatt tctactagat cagacatgaa 692761 tctgcttaag aaaacggggc ggctcgttgc gataatggcc agctcccgaa tcatttccgc 692821 cggaaactgt tcaagctgaa catcggtatt taaaatgtcc cgcgcttctc cccggctgac 692881 taaaatgagc gccgttaatc tgttctgcgg atttcgcgtt aaaatatcaa agactggggc 692941 aacgccgtct ctcgccatat cctctccaat aatgactgta cgtctgtggg acgtattgat 693001 tgtccgtgac aaggaggttt gcagcttgtt gttcgcttct ctgatcgtag tgccggaagc 693061 tgaatcaaca taccatgttt ttgaaccggc agttccgccg ccgccccctg tttgtccgcc 693121 taattggccg accaagggaa tctgcatggc cactcgatac tgatcttttt tcttatcaat 693181 ggctgagctg acaacaaatg caatgtcatt gatttctgtc cggtcccagc accccgttag 693241 aaggatacaa atgagaagcg gcaaaacaca cttatatatt gttttcttca tcttttgggt 693301 cctctctttt cgctcccttc tgtccgttgc cgcgcgaata cgtgcccggc cttctggtca 693361 tcgtccacca aggcgccctg acaaaaatat cttttacttc atctcgttta aacggagaaa 693421 tcccggataa ataaggaatg ccgaaagatt gcagcttgca taaatgaagc actaagataa 693481 tcgtgccgag cataatgccg aatatcccaa aaatactcgc caaaaacata agcgggaaac 693541 gaagcatcct gatggagata gctaagttaa accgcggaat tgtaaatgac gcgatccctg 693601 ttaacgatac gatgatcacc atgggggcag acacaattcc cgcttcaaca gcggctgtcc 693661 caatgactag ggccccgaga atactgacgg tctggccgat ggttttcggc aggcgcactc 693721 ccgcctcacg gagagcctca aaagaaattt ccataatcaa tgcttctatg atggcgggga 693781 aaggaatcgg ttcacgcgca gaggccacac tgaacattaa gtttgtcggc attaagtcct 693841 ggtggtatgt aataacggca acataaatag ccggcaaata taaagcaacg aataaaaaca 693901 tatagcgaag ccagcggatt aagttagaca tcaaataacg ctcatagtaa tcttcactgg 693961 cctgcataag ctgccaaaac gtaatcgggc ctgttaagac aaagggcgta ttatctgtga 694021 aaatggcaaa tcggccttcg agaagctggg cggcgacggt gtccggcctt tctgtgtatt 694081 gcagctgggg gaatggcgag tacgtgtcgt cttcgataaa ttcttcaata tatccgcttt 694141 ctaagacagc atcaatcttt atctttttga ttcttttttt tgctttgtca ataacctttg 694201 gatcggcaag cccgtcaata taggccaaga caacatcggt tttggttttc gtgccgattt 694261 taaaagagat cattttaagc tgaaacgttt tgacgcgaaa gcgcacaaga gcggtattga 694321 ccctgaggct ttcagtgaag ccctctcttg accctctgat ggtcgattct gttatcggct 694381 cttcaatgct tcttctttgt ccgcctttta tatttaagat caggcctttt gagtgcccgt 694441 cggcaaataa aaccgcgttc ccctcaatga tggatgcagc cactttgctc atactcgttt 694501 ctaatgcaac acttgaaatt gatagagtat tttgcagcgc ctcttcatgt tcatctattt 694561 gatccgtcaa atgcattaag aaagggcgga gggcgtgatc ctgaatatgt tcagatttta 694621 caattccttc gatataaaca ataaatccgc acagcccgtt tccaaagtca aattgtctaa 694681 atacgatgtc tgagcagcct tctgttaata aggtcagatt ttcgaggttt tccttcaaat 694741 tgggagagat cggtctgtcc tgattgtctt caagctcttt gatgagctga agcgctttgt 694801 cgcgtttatt catagaggct caccctgctt tttaatgtca tattcaataa gtgcttgtga 694861 cttttagggt aaccttgtct gtttcatata ttccagacta ggatgaaagc gctataaaaa 694921 agtgttgact acctgtatat acaggaatac aatatgatta taagttgtat atacaagtta 694981 taaaaacgga tacggagggg ttggcatggg ggaactgaac aaatcggcac gtcagattgt 695041 cgaagcagtc ggcggtgctg aaaatattgc agcggcaact cattgtgtta cacgtttgcg 695101 ttttgcttta atagatgaaa gcaaggttga ccaagagatg cttgatcaaa ttgatgtggt 695161 aaagggatca ttctcgacaa acggacagtt tcaggtcgta atcggccagg gaactgtcaa 695221 taaagtatat gctgaactgg ttaaggaaac ggggattggc gagtcaacaa aggatgaagt 695281 gaagaaggcc tcagaaaaaa atatgaatcc tttgcagcgt gctgtgaaaa cgcttgcaga 695341 tatttttatt ccaatattgc ctgcgattgt cacggcgggt cttttaatgg ggatcaataa 695401 cattttaacg gcggaaggca ttttcttcag cacaaaatcg attgtgcagg tttatccgca 695461 gtgggcggat cttgctaata tgattaacct gattgcaggc acggccttta cgtttttgcc 695521 tgcgttaatc ggatggtctg ccgtcaagcg gttcggcggc aatccgcttc tcggcattgt 695581 gctcggggtt atgctcgtgc atcctgattt gctgaatgcg tggggatatg gcgcggcaga 695641 acaaagcgga gagatcccgg tatggaatct attcggccta gaggtgcaga aagtcggcta 695701 tcagggccag gtgctcccaa ttttgcttgc ttcttatatg ctggcgaaga ttgaggtatt 695761 tttaacaaaa cgcacacctg agggcataca gctgctcgtt gtcgcaccaa ttacgcttct 695821 cttaacagga tttgcctctt ttatcattat cggcccgatt acatttgcga tcggtaatgt 695881 actgacttca gggcttatct cggtgtttgg ttcttttgcc gcactgggcg gtctgttata 695941 tggcggtttc tactcagcgc tcgtgattac cggtatgcat cacacgtttc ttgcagtcga 696001 cctgcagctc atcggttcaa agctcggcgg caccttttta tggccgatgc tggcgctttc 696061 taatatcgca caaggttcgg cggctctggc catgatgttt atcgtgaagg atgagaaaca 696121 aaaaggcctc tccctcacat cagggatttc tgcttatctt ggcattacag agcctgccat 696181 ctttggggtg aatctgcgat acagattccc gtttatcatt gcaatggtca gctctggcct 696241 ggccggaatg tatatttctt ctcaaggtgt gctggcaagc tccgtcggtg tcggcggcgt 696301 gccggggatt ttctcaatca tgagccagta ctggggcgcg tttgcaatcg ggatggctat 696361 tgtattgatc gtgccgtttg ccggaacata cgcgtatgcg agattcaaac ataaataaca 696421 agtggggagc gggacgtgtt gaacgttccc ttttcccgtt ttcaatttaa atatggtggt 696481 ggaaacagat gaaaacagaa caaacgccat ggtggaaaaa agctgtggtt tatcaaattt 696541 atccgaaaag ctttaacgat acgacaggaa atggtgttgg cgatctgaac ggcattattg 696601 aaaagctgga ttacttaaaa acgctacagg tggatgtgct ttggctgacg ccgatttatg 696661 attctcccca gcatgataat gggtacgata ttcgtgatta ttactcgatt tatcctgaat 696721 acggaacgat ggaggatttt gagcggctag tgtccgaagc acataaaaga gacctgaaag 696781 tcgtcatgga tcttgttgtc aatcatacgt caacagagca caaatggttt cgcgaggcga 696841 tctcttcaat agacagcccg taccgtgatt tttatatatg gaaaaaaccg caggaaaacg 696901 gttctgttcc gacgaactgg gaatcgaaat tcggcggctc ggcatgggag cttgacgaag 696961 catcgggcca atactatttg catctgtttg atgtgacgca ggctgatttg aattgggaaa 697021 atgaagaggt cagaaagcat gtctatgaca tgatgcattt ttggtttgaa aagggaatag 697081 acggctttag gcttgatgtc atcaacctga tttctaaaga tcagcgcttt ccgaatgcgg 697141 aggaaggcga cggccgctct ttttacactg acgggccgcg ggtgcacgaa tttctgcatg 697201 aaatgaacga aaaggtgttt tcacattacg acagcatgac ggtcggtgag atgtcttcaa 697261 caaccgtaga ccactgcatc cggtatacga atcctgacaa taaagaactt gatatgacat 697321 tcagcttcca tcatctcaag gttgactatc ctaacggcga aaaatgggcc ttggcgccgt 697381 ttgatttttt gaagctgaag gagatcctat ctgactggca aacggggatg cacgcaggag 697441 ggggatggaa cgctctgttc tggtgcaatc atgatcagcc gcgcgtcgta tcaagatatg 697501 gagatgatgg cgcatatagg gtgaaatcgg cgaaaatgct tgctacggcc attcatatga 697561 tgcagggcac gccttatatt tatcagggcg aggagctggg gatgacgaat ccgaagttca 697621 ctgacataag ctcctatcgg gatgtcgaat cgctgaacat gtatcacgcc tttaaggaaa 697681 aaggaatggc tgatcaagat attacagcca ttttacaggc gaaatcccgt gacaattcca 697741 gaacccccgt tcagtgggat gctacggaaa atggtggttt tacaacgggc acaccatgga 697801 taccggttgc aggaaattac cgggaaatca atgctgaagc ggcgctgagg gatcagaatt 697861 cggtgtttta ccattatcaa aaattgattc agattcgcaa aatgtatgac attgtgacag 697921 agggtacgta tgagataatt gcaaaggatg acccgaacat ttttgcgtat ctcagacacg 697981 gcagcaatga aaagctgctc gtgatcaata atttttacgg gacagaggcg gcctttacac 698041 tgccggactc tttagcgcct gacgaatgga aggcagaggt gctgttgacg aacgatgaag 698101 caagggaagg gcttcagaac atgacgcttc gcccatatga gtccattgtt tatcgtttaa 698161 cgaaaccgtg ttaaactaag ctgggtggtc cataatgaag gtgaataaat tcatcacaat 698221 ttataaagac atcgcacagc aaattgaagg cggccgatgg aaagcggagg agattcttcc 698281 gtctgaacat gagttgaccg cacagtacgg tacatcaaga gaaacggtcc gaaaggcgct 698341 tcatatgctc gcgcaaaacg gttatatcca gaaaatcagg ggaaaaggct ccgtcgtgct 698401 caatcgtgaa aaaatgcagt ttcccgtttc gggccttgtc agcttcaagg agctcgcgca 698461 aacgcttggc aaagaaacga aaacaactgt acacaaattc gggctggagc ctccgtcaga 698521 gctgatccaa aaacagctcc gggccaatct ggatgacgac atctgggaag tcatcaggtc 698581 tagaaagatt gacggggaac atgtgatttt ggacaaggat tactttttca gaaagcatgt 698641 ccctcacctg acgaaagaaa tttgtgaaaa ctccatatat gaatatatag aaggagagct 698701 cggtctttcg atcagttacg cccaaaaaga aattgtagcc gagccgtgta cggacgagga 698761 cagagagctg ctcgatttac gcggctatga ccatatggtc gtggtgagaa actacgtctt 698821 tttggaggat accagtttgt ttcaatatac ggaaagcaga caccgtctcg acaaattccg 698881 atttgttgat tttgcgcggc gggggaaatg agagaggcgc ctgcctgcgg cagcgcgctt 698941 ttttgtttgg tatcaaaatt gatactatcc aacaaaaatg tgcgtacttt tactttttat 699001 cataatggct acaatagaga tgagagtaat ctaaaggaga ggtgttttac atggcagatc 699061 taaagacaca aattctggat gcatacaatt tcaggcatgc gactaaggaa tttgacccga 699121 ataaaaaagt gtcagacagc gattttgaat ttattttaga aacaggaaga ctgtctccga 699181 gctcactcgg ccttgagcct tggaaatttg tcgtcgtcca aaatccggaa ttccgcgaga 699241 agcttcgtga atacacatgg ggcgcgcaaa agcagctgcc gaccgcaagc catttcgtcc 699301 tgattcttgc gcgtacagcg aaggatatca aatataatgc ggactacatc aaacgtcatt 699361 taaaagaagt aaaacaaatg cctcaagacg tgtacgaagg ctatttaagc aaaacagaag 699421 aattccagaa aaacgatttg catttgcttg aaagtgacag aacattgttt gactgggcat 699481 caaaacaaac ctatatcgcg cttggcaaca tgatgactgc cgctgcgcaa atcggtgttg 699541 attcctgccc gatcgaaggc ttccagtacg atcacattca ccgtattctt gaagaagaag 699601 gccttctgga aaacggaagc ttcgatattt ctgtgatggt ggcattcggc taccgagtga 699661 gagaccctcg tccgaaaaca agatctgctg ttgaagatgt tgtgaagtgg gtttaaaaga 699721 agaaagctgc tcgcatagcg agcagctctt ttttatgcct gattcgctct attctgtttt 699781 ctcctctgat gtaagtacat tgccgttccg agtgcgctga tcagaaatcc ggccaacagg 699841 atcgagtaca tggatgtggc tgtgtccgga agcaggccgc cagccggacc gtctgttcct 699901 gatccgcccg aaccgtttcc accagagccg ttagtcggtt gagtgccggg aggcgtatca 699961 tttcctccgt ttccgtcagt tggctgtttt ccgcctggtt tgtcggagcc tccgccatga 700021 ttgccgtcat caccgcctgt cggttgatct gacgggaatg ccggcggttt gttgtttgaa 700081 ccggaattta agatcgtgta ttcgctgaag tggtttgtat atcctgtcac catatcatca 700141 tcgactgatc cgtgacctgt ctttgtgaaa gctttctttt ttctatcgac gtgataaatg 700201 gcagggttat gggcttcttc aatatcaaac atgcgaagcg aaagctgtac gggctccttg 700261 aatgatttta tttcttttcc tttttgcttc actgtaaagt catatacatc tgacagtgac 700321 acatccaatt ctcccgtaga cttgattccg attgcagtgt ctgcggtttt aaggttcgcc 700381 attggcatct tcatgctgta ccagtagttg aacatcgtca atgaaggatc tgactctctt 700441 tctttcaaaa gtttgacctg atcttttttc actttaagat tgataggctt ctcttgagat 700501 ccttcatgta ttccataata gacaaatggc gtgttggcat ttttagcata aatcgcaaat 700561 ttgtcttcat caagtgtcca gctgccgtcc ttctgctttg tcggcaggaa tacttctttg 700621 attcgtcctt caactttagg agagaccttg tttcctagtt ttttcagctg ttcggtgaaa 700681 atctcataat caacgtagcc aaggtcttca ccatgggagg cttctgtaaa gacagaatat 700741 ccgtctcctc cggcaccgac aaaattattt gttgccacgc ggtaggtatc atccgtattt 700801 atagcaactt tgtctccgtt aggcgattca attttcactt ctaacacacg gtgtccaggt 700861 ttgttgttta atgtaaaggt atattcgatt ccggccacct gagggaaagc gccgccgcca 700921 ttttccacat tgcttaggcc ttgttcaagg gcttctttaa tttgttttcc ggttaaatcg 700981 gccacgtaaa gcgtattgcc gaacggcatc acgttgagca cctcgccgag tgtgatatca 701041 cctttgtcaa tgcctgctct gatgccgccg ccatttgtta tcgctattct ggcgccggct 701101 gcttctttcg cttttgccag cataccgtcc gcgatgaagt ttccgagatt cgtttctttc 701161 gtgcgcacat gctcacgctg gccgtcaagc gccacatccg tgtagccgac tttttcattt 701221 ttcacgtcct ctaattcatt tttgaactga tcgagctctt gttttgcttc tgggttttct 701281 tctgtatgtt catcaattgg cagcacgctc agatttgatt tatctgtttg cacaacgcct 701341 ttttcatcaa acgcgacatc aacgcgcccc aagaattggc cgtattcttt tgcctgcgcc 701401 acgatcgtcg gttcttcgtt gttcacgacc tccattttgt ctacgagggt gtgagtgtgt 701461 ccgccgatga tcaaatcaat gccttttact tttttggcta gctcaagatc ccggttatgt 701521 ccgatgtggg ttaaagcaat aattttattt accttttctt cttcttgaat cgctttgacg 701581 gtgttttgtg ctgtttcaaa ggcatcattg aatacgatgc ttttgcccgg gcttgatgtg 701641 gtggctgtat cttctgttgt caggccgaat acggcgactt tctccccgtc aacgtctaac 701701 agaatgtaag ggtgaatgcc ggcctctttc ttttcacctg ccgtaaaggt ttgcggcttt 701761 ttgacaaatg atttcagctt gggctcattt gacacatcta cgtttgcact gacaatcgga 701821 aattccggcg cttcaaagtg atagcggttc gccggatcaa cggttgcgct gtttccgctt 701881 agaaaatcag aaagcaccgt cgggcctttg tcaaattcat ggtttccgaa ggtcatggcg 701941 tcatagccca tcatgttcat cattttcaga tcggccaaac cgttccattt agtaaaatac 702001 agatcgccgg aaaacacatc tcccgcatca aggagaatat tgtgatttgt ttcgctgcgt 702061 acttcgttga ttttcgtcat tcgtctcgct gcatcatcga gatgggcgtg cgtatcattg 702121 gtgtgcatga cggtcagatc ccacagtccg tctttaggag gatctggatt tgaatcatca 702181 tcgaattgca gcttatacac accatagcct tcattcgcag acttgcctac ataagcgaca 702241 tcgtctgctt tatcggcaaa tggcttggcc aaaagcgagg attcaaacgt cagattcgtg 702301 ccggaaacag gcgcgattga ccagttgttg tctgcttttg gattgactgt tttttgttca 702361 ataatgtaat ccatcagcac ctgcctattt tcaactgcag agccgtggac aattttatcg 702421 ctcgtcagat gagggaaccc gccgcctccg gacgcacgat agttattggt gactacgaga 702481 aattcctggc ttgggctgat cggcttgcct tcataggaaa gattgatgat acgggatgaa 702541 tccgcattga tcacttttcc gttctcattg tatttagccg gttttgtcac atcgacctga 702601 tatgtgacac cgtcaatcac gtcaaaatta taggagcgga aattctcgtt cagcaaggcc 702661 tggtcgccgc ctttagctgg atcaatttga ttgaattggc ctgctgacat ctccagccag 702721 tccttgacct cgctgcctgt cagcttgacg atttgaacag tattatcgta aagatacaag 702781 tcaccgacat ttttaatcgc aagatctccg gctggaatgt ttgtatagta attggctccg 702841 tttctgccgc ctgctttaaa cggcgctcca gcggataaaa tcggcaggtt cttgtactcg 702901 gtatccttca tttctttttc agcgtaccac ttttgcgcgt cagtcacgat ctgaatggaa 702961 ggatcatctt tgacctgtgc aaagaagctg ttaatatctg cttcggtttt gccgactggc 703021 tttcggacat actccagtgt gttttggtgt gtttgctgaa tggtgtttgt aacggtttcg 703081 tttcttgatg tgacgttgcc agcaatagat tcaatacttc ctttggaatc tgctaccttc 703141 catgagccgt ccgccttttc aagcttgagg tcaatcacgc ctaaatattt gccccagctg 703201 cttggcatga cgacaggaat gccgttaatt gttccctttt ccacattgaa ctgagcaaca 703261 cccgcatact cggcggaagg aaagagtccg tgctgatggc ccgagataat cgcgtcaatg 703321 cctttcgttt tggtggcaag gtcaaacacg gcgttttctg cgcctgatga ttgcgcctgc 703381 ttttcaatgc cggtgtgggc gagggcaata atgacatctg cgccttccgc cttcattttc 703441 gggatcgttt cattggcgga ttctacgata tcctgcacct gaacttgccc ctcgagattc 703501 tttttgtccc atgtcatgat ttgcggcggg acaaagccta tgtagccgac ttttactttc 703561 tgctcattac cgttttcatc aatgagggtt ttttcattaa tcacatacgg cgtataacgg 703621 ttttcgccgc tagttgtttt gacgttggca tttacaatcg ggaaatcggc tcctttgatt 703681 gtgccgtcga gaaagtcgag cccgtagttg aattcatgat tgccaagcgt tccggcgtcg 703741 tatttcagcg cattcatgac gctgataatc ggatgggttt tcgtgccgga gataatgtcg 703801 tctttttgat atttcaccgc gtattcaccc agcggattcc cttgaatcaa gtcgccgtta 703861 tccacaagca gggtgttagg gttttgctcg cggtgctttt ggatcaattg cgctgttctc 703921 gccagaccga aatccgccgt ttctttgtcg ctgtagtaat cgtaatccat catgttggca 703981 tgaatatcag tcgtagccaa aatactcaga tgcacctgag gagccgcgct ttcttctgca 704041 tgaatgggtg gtgttgggag gattaggcta agtatcataa ttgggggcaa aagaatacgg 704101 agaatgtttt cgacgtgtgt tcgtcttttc tgtattctca ccagttctcc acctttcaac 704161 gaaatttgtg ttacagctcc tattgtaaga atattttgta actatttgta ggtgtttctt 704221 tatgattatt gtaaaaggga gaaaaatgag tattatgtag cagtatcaaa cgacaaatac 704281 tgggcattta tgcttatcgt ttgtcacaat cgcggaatgt ttattttagt gtggctgggg 704341 tagagtgttt tatgtagaca tataaagcgg gaggttatga atcatgggga aaaaaattgc 704401 agttgtttta acatattatt ttgaggacag cgagtacact gagcctgcga aagcctttaa 704461 agaagcggga catgaactga ctgtcatcga aaaagaaaaa ggaaaaacag taaaaggcaa 704521 gcagggaaca gcggaagtga cggttgacgc gtccattgac gacgtaaatt cttcagactt 704581 tgatgcgctt ttgattcctg gaggattttc accagaccag cttcgcgctg acgatcgttt 704641 cgtccaattt acaaaagcgt ttatgactga caaaaagccg gtatttgcca tttgccacgg 704701 cccgcagctt ttaatcaatg cgaaagcgct cgacggccga aaagcgacgg gctatacgtc 704761 cattcgtgtt gacatggaaa acgccggtgc cgacgttgtg gacaaggaag tggttgtttg 704821 ccaggatcaa ttggtcacta gccgcacacc ggacgatata ccggcattta accgcgagtc 704881 attggcattg cttgagaaat aagaaaaaac ggacgctctt gggcgtccgt ttttttgttg 704941 cttaggcttg agcacctgtc agtttcttgt acctgtaata caagaaagca gctgcagccg 705001 ttccgatgac cgcaatgccg aagtcgaata tgaaaatatg ggcgatgccc cccgcttttg 705061 cgataagccc tgttgcaatc ggcagcagaa tcgatgcaag acttgaagca gtcgctacaa 705121 ttccggtaac ggttcctttt cgcttccaga aaagctctgt cattaacgta atggtaattt 705181 gaaacacacc cgcagttgaa aagcctaaga aaaaggcagt gatgtccagc acaactggga 705241 tatgaacggt cagcatgact gcgagcgtac ataaagtaat aataggatat aagagcgtta 705301 tgaagacagg tttgacccat ctattcagca aaacggctaa taataaaaca gatgccagag 705361 atcctatact ataatagctc agcaattgta cagatgctga ttcagctaaa ccggctgcct 705421 tttgcgcgta gctcgggagc cagatttgag aaaccgtaaa taaagccgtg gatgtaaaac 705481 cgatgataat cagtgcggtg ccttccttct gaaaaacggg ttcagacaag aaaacgggag 705541 attcctgttg gccgctatta gttggtttct tatgtttttt aggaaacgaa agcgttgata 705601 aataaataat attcaggaga tagaccgctg ccggcagata aaaagcaaat ccgtaaaaca 705661 tgctgtggtc tgctaaaaat gtgatcaaaa gcggcaaaag tgcggccccc acagacataa 705721 aggctttaac caagacattt gccgaaccgg aagcagacgg aaagagctcg gttagggccg 705781 gatatgttcc ggcatccatg gctgaattag cgactccggc taataaagcg aacacaaacg 705841 ccagctcata gctcggtgat aaaggaatac cgactaaaaa gacggccata attcccgcag 705901 aagcgacaac aagcggcttt ctgccgattt tatctgatag aacgccggaa atgccgtatg 705961 tcagcagttt gccaaacccg atagcggcaa tgacataact gatgccggtc ggatcggtat 706021 tccactgttt tgttaatgaa gacatattgg atgcgagaat gatgttgacc atccccagaa 706081 agaagtagtt gatatacatt ccggatgctg ttttgataga tgtcgtttgc atgcttgtac 706141 tccttcaaat cttattcgaa cactttgctg ttttggtttg gggaaatgat aaaaaagact 706201 cgccgagttt ccggccagtc tccattattt acgaagcgag gctaattctt gagcaatcgc 706261 ctgcatttca cttgggctga atgattcttt tttcatcacc attctgtgaa ggtacgtgag 706321 gtcttcaatc ttctcatcac tgaaatcctc cgctttgatt acgccgacgt tcagcatgtt 706381 cagcttttgg gaaatctctt caatcatttg agttaatgtt tctgtatttg ggctggacaa 706441 agggttccat cctttctatg cgcaatatag gtatgtttta ttctaacaga attccatcag 706501 aaaaaaaccc tattctaaaa gcaggctgtt cattccaaaa aagtgaagac atcagttgaa 706561 aagaaaatga acatcctact aagatattca tgaaggtttc tttttagaga aataggggca 706621 aagaataggg aggttgcaca tcatgataag cgtgttattt gtttgtttag gtaacatttg 706681 ccggtctccg atggcggaag cgatttttag ggacctggca gccaaaaaag gattagaggg 706741 gaaaatcaag gcggactcag ccggtattgg cggctggcac atcggcaacc ccccgcatga 706801 gggaacgcag gagatattgc gcagagaagg aatcagcttt gatggcatgc tggcgcgtca 706861 agtcagcgaa caggatctgg acgattttga ttacatcatt gcaatggatg cagaaaatat 706921 cggaagtctc agaagcatgg cgggttttaa aaacacctcg catatcaaaa ggctcttgga 706981 ctatgttgaa gattcagatc tggctgacgt acccgatcct tactacacag ggaactttga 707041 agaggtctgc caattaatca aaacgggctg tgagcagttg cttgcatcca ttcaaaaaga 707101 aaaacaattg tgagtgaaag gagaatttgc atgaacaacg aacgtttaat gctgaaaggg 707161 atatttctcg gagctgcggc aggcgcggcg ttatcactgc tccataagcc gacaagacag 707221 gcgtgcggga tgagatggct gacatgcaag cataaacttt cactgtacaa aagcaaccca 707281 gagctgttaa aaaacactgt catcacaaaa gtggatgagg ccaaaaagct cgcccgaacg 707341 ctttcaaagg aagtcgactt tgtgaaccag caggtgaaag agctgaagaa aacaacgccg 707401 caagtgatgg aactcgtgca agaaacgaaa gagcattttt caaaaaaatg atcaaacatg 707461 cgaggtgaga cgacatgagt tttttgaaag agcttttcag cagatacacc cttcatgaag 707521 gacaaagtaa atcagcggag ctggcgtatt tttttctatt gtcactgttt ccgtttttga 707581 tttttatgct gacgctcacc gcgtatcttc cgctttctac cgatgatgtt ttaggagtca 707641 tagaacaata tgctcccgcc agtgcgatgt cactcgttga atccattacc catcaaacct 707701 taaataatcg aaatggcggt ttgctgtcat tcgggattat cgccgcatta tggtctgcgt 707761 ctaatggaat gaatgcgatc gtccggtcgc tgaaccacgc gtatgatgtg gaagaaaacc 707821 gctcttttat cattgttcgt ctaacctcga tttttttgac gattgccatg gtatttacga 707881 ttttagtggc tttgcttctg ccggtatttg gccgggagat tggaaggctc gcttctgact 707941 ttgtcggcgc gtcggatctg tttttatccg tctgggccgc cattcgctgg ggtgtcagcc 708001 cgcttgtgct tttgattgtt ttttccgcgc tgtatgtgat tgcgccgaac aaaaagctgt 708061 ctctccggtt tgtcatgccg ggtgcggtct ttgcgactat cggctggatc attgtcagca 708121 cattgttttc attttacgtc agcacgtttg cgaactatag cgccacttac gggagcatcg 708181 ggggaatcat cgttctgatg atttggtttt acttgagcgg cattttaatt atcctaggcg 708241 gagaaatcaa cgctctttta cataaacgta aaaagcttcc tgatgaaaat ccctaccatt 708301 agcgcaccct ataaacgaac ttcggttcaa aaagaagtcg gggggatatc gtgatgacca 708361 agcatacgaa aaaaggcgga agccataaca aacaaaactc gaaaagcaaa tcgagccata 708421 aaacaagcgg aagcgccaac ggacaaaacg gctaccatta gcataaaagc ctcctgacat 708481 gatgtcggga ggctttttga ttaagaagat gaagaatagg tttcagccgg tgaccagctt 708541 ttcggtttgc ccagcacaag ggccagccac acagagctaa gcgtgagagt aatgaagtag 708601 aacaagtttg cgctttcaaa tgtctgcata taccagccgc cggcaactgg gccgaggatg 708661 ctaccgagac tgaatgtaat gccgcaaagc aggtttcccg ccggcaggag gtgaggcgga 708721 agaaggtctg tcatatagct gatgccaagt gtaaaggttg atccgactgc cattcctgca 708781 ataaaaaagc agccgccgat cacgtagggc gaaggaaata caccggcgat gaaaaagcaa 708841 agagccccag tcagtaaaat caccagcagc acattccgcc tgccgtattt atcgctgagg 708901 atgccgagcg gaaactgaaa gataatgctt ccaatcgcaa atgcgggaag gatgatcgct 708961 actgcgtcta ctgatatccc caaacggagc gcgtacaccg gaaagcttcc gttcagcgcc 709021 gtttccagaa agccatagcc aaatgtaggc ataaaggcaa cccacccaaa cagcatggcc 709081 tgataaaatc gcctgaaact attgtctgat ttggtttcat gaggactggt ttccgggtat 709141 gcattttgta gaaagaaaac aaaaagccac gcaaacagac tgatgcagcc ggacacgata 709201 aaaggaagcg acggactcag cttgacaagc ggcaccatga acgggcctgc ggcaaagcca 709261 aggccaaagg aaagcccata aatagacagg tttcttccgc gattttgttt tgatgacatg 709321 gaggtcaccc acgtttgcgt agaaaagtga agcatgtggt cgccgattcc aatgaacagg 709381 cgaagcagga accagaccca aactgactga agccaaataa atccgaataa gcttaaaatg 709441 acaatgcttc cgcccatgac gatcagcggc ttgaacccga gctttctgag cggtgcttcc 709501 ataaacggcg aagccaaaag cacaccgata tacagcccgg tcgcgtgcag gccgttgata 709561 gcagcggatt ctccatttgt ttcaaaaatg attgaaatga caggcagcag catgccttgt 709621 gaaaacccgg aaatggaaac gagcaagaca aggataaaga aatgaaatcg tgacatcgtg 709681 tcagttctcc ttatatggaa tctatgttga tcgtacaacg ttttccaaaa gcaggcaacc 709741 tgaaaaaagc ctatatcacg ctatacattt gccctcgtgt aatcatgaag gtttttgtga 709801 agaataaaaa taaaacaagt cataaaaaag gagctatttc accatgaatc gtatcttttt 709861 tattttagtg gcggccggtg ttccgctttc tgtgattggc agtttgatgc attggccttc 709921 cgcggttcta tttgcagttt attgcgtgac gattatcgcg cttgcaagct atatggggag 709981 ggcgacagaa tcactgtcca tcattgcagg accgcgtatc ggcggtttgt tgaatgcaac 710041 cttcgggaat gcggtggagc tgattatttc cctttttgca ttaaaagaag gcctgacagg 710101 aatcgtgctt gcctctttaa ccggttcagt gctggggaac ctgttgctgg tagcgggcct 710161 atcgtttttt gtcggcggtt taaaatataa gcggcaggaa tttaatatcc atgatgcccg 710221 ccataactcc gggcttctga tttttgccat cattgtcgcc tttgtgattc cggaggtatt 710281 ctctgttggt atgggaaacg ccagcaagct caatttaagc atcggcatca gcatcattat 710341 gattctgtta tatgtggcgg cgctgtactt taaacttgtc acgcatcggg gcgtttatca 710401 gccgaataat gccgctcaga ctgaagaaga ggaagagcca gaatggtcag ggaaggttgc 710461 gacgattgtc ttgtttgcgg caacgattgt ggttgcatac atatccgaaa acctggtcca 710521 tacctttcac tcggtggctg aacagttcgg gtggagcgag ctgtttattg gggtcatcat 710581 cgtggcgatt gtaggaaatg cggcggagca tgcgtcagcg attattatgg ccttcaaaaa 710641 taaaatggac attgctgttg aaattgcagt aggctctacg ctgcagatcg ctatgtttgt 710701 cgcaccggtt ctcgtcatct gttctatctt ttttccgaca agcatgccgc ttgtatttac 710761 attgcctgag ctcgtcgcga tggtatcagc ggttctcttg atgatcgcga tttcgaatga 710821 cggggattcc aactggtttg aaggggcgac actgcttgct gcatatgtca ttatggcgat 710881 cggctttttc cttctttaac ctgaaaaaat gatggataac aacaaagcgg gatgaaaaga 710941 ctaagggaaa atgccataga aagagtgata tgatgaaaaa gctatttcat tccacactta 711001 ttgtgttgtt attctttagt tttttcggcg ttcagcccat ccacgcgaaa aagcagttta 711061 aggttcctaa ttctgtcgca agcatttcaa aggaaaacac gtatccgaat gcttcacagg 711121 atcagccaat gcttcagccg agcaagctgg caaaggaatt gctcgatcat tctgaggtaa 711181 agattgaaaa tccgcatctc atcaaaatgc tgaatgaatc caacatatcc ggcacaccgc 711241 ttgcagtagg gtaccgggcg acaatatttc tcgggaaatg ggcgctcggc tatgaatcaa 711301 atgaaacagt cgcaaactgg gaatataaaa aaatcaatac aaaccgtgcg gataaccgcg 711361 gcgggaaaga aacggctgaa atgcattatg cccaggaaca gcagtacaga gtgaagggcg 711421 gcttgacagc taaagttcca aatgctgaag atgtcaaaag catgatgatg caaaaagcaa 711481 tgaagaaaac gaacctcccg cttgcatttg agacggtcat cggggctggc acaaaacggg 711541 atcagattta taaagtcgct cctaaaaaaa tcggttatct acatgcatat gcaccggctg 711601 tgaatgaaaa aggaaaagtg acttacggag aagtgtactt agtgctgaaa ggaaataaac 711661 gaaaactcgt cgtgaaaaat gtcacgtcac agggaatcgg cgcgtggatt ccggttcaag 711721 atcatgtcac gtttggcttt cagctttcct cactgccaag ataaataaaa aactgattcc 711781 aactcggaat cagttttttt gtttattggg ttctctcgat tcggaccgct tcctcaagca 711841 tttgcacatt gttttggtag agctggcgaa cgagaacccg tcttactgca aggctggcac 711901 tgaaataatc atcatctttc accatgcctt taaccgtaaa ttcgacgccg cgattgattt 711961 tattcaatgc ggtgatgccg tggatttgaa acggttctgt cggattgccg aattcatccc 712021 gcttcaatga atcacgaagc tcttcattca gcatgtcaca tgcctcttcc aacacgctgt 712081 acacgcggtc cggatcttct ttaaagctga taagaaagga ttcggtaatc cgcataaaat 712141 caatattata gttctctatt tgtctgacct cgccgttgct gatggtgagc agcttcccgc 712201 tccattcccg gatttgcagc gagcggaggc cgatttcctc cactgtcccg ttgaacaagt 712261 tgttgacggt gacataatcg cctttgtgca gctggcgttc atatattaag aatacaccag 712321 ccagcacatc tttgatcagc gattgggcgc caaaaccgat cacgatacct gctacgcccg 712381 ccccggccaa tatcttgccg aaatcatgca caaataaaga aataacgtaa aagataaaac 712441 caattgttgc cgtatactgg gtgacagaac ggacaaggct ttcaatcgtt ttttcctttt 712501 tttcttcaat aaagtccgtc cgtttaaaaa atagctgtac cagccggttg atgataaaga 712561 caccgatcca aaggataacg gcaacgagga gaatatcgac gattttattt tgaaaaatct 712621 ccgtaagtgt ttctttcatc cgcatctaac tcctggcttg acgttttgtg aagtctgtat 712681 cctgataata actgtttttg acaagaacat tcggtccgag gcaccggaca ttcgggcagt 712741 ggcaactcag ttctttcgca agcttggtct ctctccactt ttcataggcg gaagggaggc 712801 tgtccgtctg aatgttgcca agcggcgggg tatcaccgaa atcggtcacg ataatgtttc 712861 cgtcgaaaat gttcacattc aggcgggatc ggccgtcagg gtcatttcgc actgtgacgt 712921 ttttcgccgc gcgaagccgg cgaagcagct tttggtcgtc ttcgtccgga ctgcaggcat 712981 aaaacggcag cgttccgaac agcatccacg tattttcatc acgaatatcc agcaagcggt 713041 gaatggcctg tctcatctct ttcaggctga gggattcaag agcgcttgcg aaatcgcttg 713101 gatacattgg gtggacctcg tgacgctgac atttcatatc ttctgtgatt tggcggtgaa 713161 tatgctcaat atgcggaagt gttcgtttgt tcagcatcgt ttccgcagat accattactc 713221 cggcatccac gagcgtgcgg ctgttttcga tcattttttc aaaatagcgc gcgcgctgtt 713281 cgaaggtcgg ttttctgtcc atcatggcaa agccgatttc agcaaaatct tcaactgttc 713341 cccagttatg tgaaatatgt agcacatcga gatacggaat gatccattcg taccgctcga 713401 tgtcgagggt cagatttgaa ttaatttgtg tccgcacacc ccgttcatgg gcatatttca 713461 ataaaggaac aacatattct tttactgatt tcaacgaaag catcggctct ccgcctgtga 713521 tgctgatgga tctgaggcgc gggatttcct ccagccgttt taacagaaga tctattggca 713581 gagcattcgg gtctttaggc tgcaatgtat agcctacagc acaatgctcg catctcatat 713641 tgcacagtgt cgttgttgtg aattcaacgt ttgtcagctg catgtctccg tattggtcaa 713701 catccatata ggcttcccaa gggtcaaact cgggcgtaat cggacgcagc ttcgtgtttt 713761 gtgtcatgac tatctaactc ctttataaat gggcatacta acgctgccaa cagttaattt 713821 tagacctgat ttgccaagat cgcaagtagc gcggcgattg aaaaacggca aaaaatgagc 713881 taccataata aaaaatgaat ggaggaacag aatggggaac gccgtaaaca ataaagatca 713941 gcagattgat tatttaaaga acagacttga catgtttatg aacgtcatcg attcattaga 714001 ccctgaagca accgacgttg aagatataga caggcttatc agcatgcttg atgacctgga 714061 agccaaatac gaacgtttta aaaaagattg ggaataaaac cgcgtgcccg ccgcggtttt 714121 tttattggca taaagcaaca gtataaaaca aagtctctat ctgtaaaata agaaaaaatg 714181 cagaaggagc gctggccatg aagtggatgt gttcaatatg ctgcgccgcc gtattgcttg 714241 ccggaggtgc agcacaggcg gaagcggtgc cgaatgagcc gattaattgg ggctttaaac 714301 gaagtgtcaa tcatcagccg ccagatgccg ggaagcagct gaacagttta attgaaaaat 714361 atgacgcgtt ttatttaggg aatacaaagg aaaaaacgat ttacttaacg tttgataacg 714421 gatatgaaaa tggctatacg ccaaaagtgc ttgatgtctt aaaaaaacat cgcgtaacag 714481 gaacgttttt tgtcaccggg catttcgtaa aggaccagcc tcagctgatc aaacgaatgt 714541 cagatgaggg ccatattatc ggcaatcatt cctttcacca tccggattta acgacaaaaa 714601 cagctgatca gattcaggat gaacttgatt cagtcaacga agaggtttat aaaattacgg 714661 gaaagcagga caacctgtat ttgcgtccgc cgcgcggcgt gttcagtgag tacgtactga 714721 aagaaacgaa acgcctcggc tatcaaaccg ttttctggtc ggtcgctttt gttgattgga 714781 aaatcaacaa ccaaaaggga aagaaatatg cctacgatca tatgatcaag caggcgcacc 714841 cgggagccat ttacctgctt cacaccgtat cgagggacaa tgcagaagcg ctggatgacg 714901 cgattacaga tctgaaaaaa cagggctaca cttttaaaag cattgatgat ctgatgtttg 714961 agaaagaaat gaggctgccg tctttgtaaa agagaaagac ctctccttaa acggagaggc 715021 ttttctttat tttatacatt taatcagtgc ggcccagtcc agatccccga agcctttctc 715081 aatcccgctt tcaaaatggc tcttggccag ctcggcaaga ggaagatttg cagaaacccg 715141 ttttgcggcg gcgagtgcca ggttggtatc cttcagccct aaagacattt tgaagccggc 715201 cggctcaaat ttctgctcgg ccataatggt tccgtaattt tgatagactg gagaaccaaa 715261 gagcgcgctg gcgatttcta aaaattgttt ttgttctaag ccgtatttct ccatcattaa 715321 aaaggattca gataacgcct ccagcatgga cacaagcaag aaattaatgc tgattttggc 715381 tgcatttgcc gtcttgcttt cttcgccgac gtcaaatatc tgctggctca ggctgtcgag 715441 cagaggcttg gcagcttgct ttgcttccgc cggtccggct gttatgatac ggagcgcggc 715501 tttggctgcg gcatccggtc tgccaaggac aggagcggcg agaaaaaatt gtcctttctc 715561 tgcatgagcc gctgcgagct tttctgagaa ctcaacactg attgtgctca tcgagatgtg 715621 tatgccgttc tctgctaatc cttcaagcag cccgtcttct ccgaatgtca cggtgctgac 715681 agaatcatca tctgcaagca ttgtgatgac aatatcagcg gactttgccg ccagccgcgg 715741 cgtatcagct gcctgtgcgc cttctgtgac aaggtcttct gtcttttgtt tcgtccggtt 715801 atagacagtc aattcgtagc ctgcttgaag aacatttcgg gcaatgggct gtcccatatt 715861 gccgagtccg atgacagcaa ttttcaatct aatcactccc tgaatatttt ttccattata 715921 aacaatatga acagaatatg catagcgatc ggcttacaac aaaaaagaac agctgctcgc 715981 tgtcctcatt taaaaatatt gaaccatcct ttatgtacaa accaaatcag cattccaatc 716041 acaagcgcgg ccatcaggcc aagtacagcg aaatatccgt atttccaatg cagctccggc 716101 ataaagtcga agttcatacc gtatacaccg gcaataaagg tgagcgggat gaaaatggtt 716161 gatacgatcg tcagtgtcat cataatcgca ttcatccggt ttgagtttag cgtcacgtag 716221 ctgtcacgca agtcggacgt catgtcacgg ttggattcca caatttcaga caactttaac 716281 aaatgatcat atatgtcgct gaaataggct ttcgtttccc gctgctcttt cacatggtca 716341 aggcttaaaa tccggtagag caaatcacgc atcgggataa tcgtccgtct caaatgcaat 716401 aggtctgttc tgagatcaaa cacctcgttc atcagcgttc catacgtttt gtggggacgg 716461 ctttcttcaa tttcattcag ccggtcttca attttataca cgagaggaaa atattcatca 716521 acaagctgat ccatgatcat ataagaaata tgcccgggcc cttttttcaa tatgtccggt 716581 gaagcataca aacgctcccg gactttagcg ataccgggcg tttcgtgtaa atgaaaggtg 716641 acgacaaatt tttcgccttg aaagatatcg acttcctccg tctcaagtgt ttccttattc 716701 agcgcatgaa tcacgtaaaa acgatagccg tcataatggt caagctttgg ccgctgcata 716761 tgctggaagc aatcctcaat ggcaagcggg tgaaaatgaa aaaaatctct caataacgcc 716821 gtttccgtat cctccgggcc gtaaaaatca acccagtacc atgcaatatc aggctgttcc 716881 actcgttcga tcggtatatt tttcagcagc tgatgctctg ttgtgattgc ggtaatgttg 716941 atcataaaca accctccacc tgccattata tcatgcggtc tttatgagaa aagtatacgg 717001 tactctctgc ctaattccag cggcatgtta tactgaacaa aaacggaaaa aagggtggat 717061 ctcatgtgga aggaaaaagt atctgtcacg cctccgtatc attttgaccg cgtgctggac 717121 aggctgtctt tagaccccct caatgctgtt gatcgagagg cgagggaagt ccgtgtgcca 717181 atcagaaatc aagcggggga cgtatgtatt gtaaaggtac aggcgttagg ccatgcgggc 717241 gagcctgagt tcctcgtcag cggggaaacg gatcagggag aaatgatgaa ggaaatcaag 717301 cggatttttc aatgggaaaa tcatttgcag cacgttctgg atcatttttc aaaaacgagc 717361 ctgtccgcca tttttgaaga gcatgccggg acgccgcttg ttctggacta cagcgtgtac 717421 aactgcatga tgaaatgcat tatccaccag cagcttaatc tttccttcgc ttacacgcta 717481 acagaacggt ttgttcatgc gtttggcgag cagaaggatg gcgtgtggtg ctatccaaag 717541 ccggaaacga ttgcggaact cgattatcag gatctgcgtg atctgcaatt cagcatgaga 717601 aaagcggaat acaccattga tacatcaagg atgatcgcag aaggcacact cagcttgtca 717661 gagctgccgc atatggcgga tgaagacatt atgaagaaac tgatcaaaat caggggtatc 717721 ggcccgtgga ccgtgcaaaa cgtcctcatg ttcggacttg gccgtcccaa tttattcccg 717781 cttgccgata tcggcctcca gaatgccatc aaacgccact ttcagctgga cgataagccg 717841 gcaaaggatg tcatgctggc gatgagcaag gagtgggagc cttatttaag ctatgcgtct 717901 ttgtatttgt ggaggagtat agaataattc gtctgacaat gaaggaaatc ctgcaaacgt 717961 gttatactag aaagatgtga aaaaaccatt tcactttctg ccatccgcag aaagcttcat 718021 atagaaacgg agagaacaac gtgaaccaac aaaagaaaca ggcgcccgtc gaactgaagg 718081 tcggacaaac ttttccgctg acgattaagc gtctcggcat taacggagaa ggtgttggct 718141 attttaagaa aaaagtcgtc ttcgtgcccg gcgcgcttcc tggcgaagaa gttgttgtgc 718201 aggccacaaa ggtccagccg aagttttcgg agggccgcat taagaaaatc cgcaaggcat 718261 ctgagcaccg ggtggcaccg ccttgccctg tttatgaaca atgcggcggc tgtcagcttc 718321 agcaccttgc atacagccag cagcttcggg aaaaacgtga tatcgtcatt cagtctcttg 718381 aacgccatac gaagtttaaa gttgaaaaca tggaaatcaa agaaacgatt ggcatggaca 718441 acccgtggaa ttaccgcaat aaaagccaat tccagatcgg gcgctcgcaa agcggcagca 718501 tcatcgccgg cttatacggc cttgattctc atgatatcgt gccgattaaa gactgtatcg 718561 ttcagcatcc ggcaacgaac aaaacaacag gcatcgtccg ccgcatttta gaggacttca 718621 atgtgtctgt ttataatgaa agaaaacgaa aaggcgacgt tcgcacgatc gtgacgagag 718681 tcggctttga aacaggcgaa gtgcaggtcg tgcttgtaac cgcaaaagaa acgcttccgc 718741 acaaggaaga aatcgtcaaa gcgattcaaa agcgattgcc agaggtcaaa tccattattc 718801 agaatgtaaa cggggcgaaa acctcagtga tttttggtga gaaaacaaaa cagctcgccg 718861 gaaaaacagt gattcaagaa gtgctcggcg acgtatcttt tgaattgagc gcccgcgctt 718921 tcttccagct caatccggaa cagaccgtca agctgtatga tgaagtgaaa aaagcggcgc 718981 agctgaccgg aaaagaaaaa gtcgttgatg cgtattgcgg cgtcggcact atcggcatgt 719041 gggttgcgga cggagcgaag gaagtccgcg gcatggacgt catcaaggaa tcaattgacg 719101 atgctaagaa aaacgccaaa aaacacggca tggcaaatgc cacatacgta acaggaacag 719161 ccgagcactg gctcccgaaa tggacgaaag aaggcttccg cccggacgtc gtcattgtag 719221 acccgccaag aacgggctgt gacagcacgt tcttggacac gatcaaaaaa gtcaaaccga 719281 aacgctttgt ctacgtttcc tgcaatccat ccacgcttgc gaaagatttg cagacgctgt 719341 cgaaggacta tcgcgtggac tatattcagc ctgtcgatat gtttccgcag acggcgcatg 719401 ttgaagcagt ggcgaggctt gtattaaaat cgtctaacta aaaagaacat ttcccagtca 719461 taaaatagtt ttcctaataa gacctggatt tcggtaaaat aaacaattcc gatttccggg 719521 tctttttcgt gcgcagctct tgtcctaacg gtctgttctc aattttatct tccttctttt 719581 cgcggagatc tttattttaa ctggcgaaaa gaattgaaaa aacgtgttga aaagcaggtg 719641 aaaaaaagcg ttatttaacc ggaaaaatat cctcccagta tgtttaaaat acatgagtag 719701 aatgatgtaa aatcatagat gtattttcat aatttgtaaa attatatatt gacttgcagt 719761 tattacgtgt gaaatattga tgataggaat ataaggaaag tatggcgtat atcatttcaa 719821 gagtcattcg atgtaaaaag ttgaaacatt gtaataaatg aaagaggtga aaatgatggc 719881 caaccccatt ttaaaatgca taacgtatga gcactacaac aattaaataa tagtgccgag 719941 acgataacaa ctattacagt aatacctaca atggttatat ccttgcgaca atcatgcttc 720001 ataatataat gattttagat tgacacttgg ctaaaaagta ttgcagagaa ggaaatggat 720061 aattaaatgg ataaagtata taaaagaagt tggtttcaaa catttttggc atttttagta 720121 tctcagcttt attttaattt tgtagaatta acgggatggg gtcctaagta tagagaaatg 720181 aatggattcc cagcaaacat agttgaacta gatttctttc aaacatatct ttcattctat 720241 gataatccat ggtttaatat tattactgtt ttcttgggag ttttcactat tatacaaata 720301 attacaggga taacaaagga tattcgaaat taaagcaata acttctgatg ccttatttaa 720361 tgatgaaaga aaatgtacac tttcttaatt atcttatgag tgaagactgc gacacttagt 720421 cagcagtcta ttttatggtt ctggatcagg attaccgaat tataacccta tacaaatata 720481 tagtaggttg ccacttgctg cgttggttat tttctaaatc atgagcaaat cccaaatgat 720541 tcagattgaa gttcttgaat tcttttaaat aagggtttat tttctcttct catcctcttt 720601 actccatgtg attcacaagt ggtagcagct taagtaggtt ttttcattct cttgagtact 720661 cagttatacc acccccaact caatttgctt tatctctatt agtttttccg caaatatgat 720721 atagagatac ggatatggtg tagtgttaaa tatcttatct tcaataacag ggcaattatt 720781 ttgcgttggt aatatggaga actcatatga tattctattt aggttggaat cctttttatc 720841 caaaaagttc aaaagcaagg ccactaagaa agacgaaggt cagcgccagt taaccagaat 720901 ataaaaaata gggtagataa tcatcccacg tgaaatcttc aaaatttact atagattgat 720961 aagaaatgct ttcgcatgcg ataagtgtaa aagaagcatg gtcagttttt aatttgggat 721021 aaaggttcag ccgtatccca taatgaaagg atttgatttt tgttatgaca gaaaatttct 721081 ggcgtgaatt accacggccg ttttttgtac tggcaccaat ggaagatgtg acagatgttg 721141 ttttccggca tgtagtaagt gaagcaggca gaccggatgt gttttttaca gagttcacaa 721201 actcagagag ctattgccac ccggatggga aggatagcgt gcgcggccgt ttgactttta 721261 cagaggatga acagccaatt gtggcccata tatggggaga taagcctgaa aacttccgta 721321 aaatgagtat tggcatggca gagttaggat ttaaaggact agatatcaat atgggctgcc 721381 ctgtgcctaa tgtggcgggg aatggaaagg gaagcggcct tatttgccgt cctgcagttg 721441 cggcagaatt aatacaagct gcaaaagcag ggggattgcc tgtaagcgtg aagacaagac 721501 ttggatacac ggatgtggat gaatggcgcg agtggctgac acacattttg aaacaggata 721561 ttgcgaatct ttctattcat ctgcgtacaa gggcagaaat gagcaaagta gatgcgcatt 721621 gggagctcat cccagagatt aagaaacttc gtgacgaggt ggcaccagat acattgctaa 721681 caataaacgg ggatattcct gaccgtcaaa ctggcttgaa acttgctgaa caatacggcg 721741 tcgatggaat tatgataggg cgcggtattt ttacaaatcc tttcgctttt gaaaaggagc 721801 cgaaagagca tagcagcaag gaattgcttg atctcttaag gctgcatctg gatctccatg 721861 atgaatattc aaaagaagaa gcccgtccat acaagcctct tcctcgcttt ttcaagattt 721921 atctccgcgg attccgaggg gcaagtgaat taagaaatca atgcatgaac acaaagtcaa 721981 cagatgaagt gcgtgcattg ctcgacgact ttgagagaaa gtatcttgat gggatagagt 722041 aacagcagtg cttgattcaa aaaaggctaa caaaataaag ggatttttac acaattcttg 722101 actaaaataa acctggattt tcggtaaatc cgggtctttt ttgtacgcag cttttactca 722161 gcctgtcttt tctctaattt attgtaagaa aataatggta tatttagtgg agatatcata 722221 taaaggggga gaggaaaatg aaacggctat gcatcatccc ctgcggcaag aaaaaaatct 722281 gggatgtcca gcctgatgcc gggccggtaa gagcagagga cgcttatctc agcccgtttc 722341 atcaggcgtg cgagcggtat gcaaaaacat ttttcgatga gtgggtgatt ttgtcggcga 722401 agcacgggtt cctccgccct gatgatctcg tttcgggaaa ttacgatgtc acttttggca 722461 ccggtcatcc ggaaatcatg acagcggacg agctgcgccg tcaatttcac gaaaaaggct 722521 tttctgatat cgaagagcta gtcatgcttg gcggaaaaaa atatcgaagc gttctaaacg 722581 ccgtcatcgg agaacaccag catatcagct ggccgctatc atcatacaaa ggcataggct 722641 atatgctcca agcgctgaac cgggctgttg aagaaaagca tgaactgtag cacgtacata 722701 tgaggaaaag agtgggaaca tgaaaaaact tgtgtttggc ttgcttgcca ttgtgttatt 722761 cggatgcgga ctatatatct atcatgtatg gttcggtgat ccattttcga aaaatgctgc 722821 agaacagaag ctagtgtctt atgtgaaaca aacctatcct aagaaagaaa tcaagatcac 722881 gaatggggta tataacgcta aaacgtctga atatgtattt gaagcaacct cccaatctca 722941 tcgctaccca atgtgtacga agggatttct gcatcctaaa gtaacgtgcg atggaattga 723001 agaagcgtat accgaatcag tagcaaaaca tgtaaatgaa gaagcaacga aggcaatcga 723061 agcagatctg aaaaaagcgg ttcctcgatt tataaaagct gatgctgctt tgagtatcga 723121 aaacggacag ttcacgttag atacaaaatg gaacaaaaag ctggctgaaa aagcgcctat 723181 gagcatgacg attcagttag acgccagcgg gttatcaaaa acagatgccg caaagatggc 723241 ggaaacggtc agaaaaacgc ttaatgaaaa gggatataca tactcaaacg gcacgataga 723301 ctgtatgcag aaggacgggg acggcggtat tggatatgtc aaatattcaa ttgattttct 723361 ttcaaaagca gctattcagt caaacgatgc agaggaacta ggaagttaaa aagatttcca 723421 aggaaataaa tacgtcgatc attgtcaaag gccgggtgat atccggtctt ttttttgcat 723481 gctgtaaaac gagacaaatg aatcagtttg agacaaaacg agacacacgt ctcaaactgt 723541 ctccaaagtg aagatgagaa gactgatttt acgggctcaa aagactggca cacttcttgc 723601 atttataatg gtgaacccta aatagaagga ggcgcacaaa atgaaattgt taaaacgaga 723661 aggcttgtca ttaactgagg aaaaagcgct gtggatgtac caaaagatgc tggagatcag 723721 gggctttgaa gacaaagtgc atgaactgtt cgcccaggga gtgcttcccg gattcgttca 723781 tttatatgcc ggtgaggaag ccgtggctgt aggggtgtgc gctcatttac atgatggcga 723841 cagcattaca agcacccaca ggggacatgg acattgtatc gccaaaggct gtgacctgga 723901 cggcatgatg gcggaaattt tcgggaaagc gaccggattg tgcaaaggca agggcggttc 723961 tatgcacatt gcggatcttg ataaaggcat gttaggcgca aatggaatcg tcgggggcgg 724021 ctttacgctc gcatgcggat cagcgctcac ggctaaatat aaacagacta aaaatgtaag 724081 cgtttgcttt ttcggggacg gggcaaataa ccaaggtacc ttccacgaag ggctgaattt 724141 agcggctgta tggaaccttc ctgtcgtatt tgttgctgaa aacaacggct atggcgaagc 724201 taccccattt gagtacgcat cagcctgtga ttcaatcgcc gatcgggcgg ctgcttataa 724261 catgccgggg gttacagttg acggcaaaga tattttagca gtttaccagg cagccgagga 724321 agcgatagaa agagcaagaa acggcggcgg cccgtctttg attgaatgta tgacctacag 724381 aaactacggc catttcgaag gagatgccca aacctataaa acgaaggatg aaagagttga 724441 gcaccttgaa gaaaaagatg ccattcaagg ttttaaaaac taccttttaa aagaaacaga 724501 tgctaataag ctgtcagaca ttgaacagcg tgtcagcgaa tcgattgaaa aagccgtctc 724561 gttcagcgaa gacagcccat atccaaaaga ttcggagctg ctgacagatg tgtatgtgtc 724621 atatgaaaaa ggaggaatgt aagagatggc gagagtcata agcatgtcag acgcgatcaa 724681 tgaagcaatg aagcttgcga tgagaaaaga cgaaaatgtg cttttgatcg gtgaggatgt 724741 cgccggggga gcggcggtcg atcatttgca ggatgatgaa gcatggggcg gtgtattagg 724801 ggtcacaaag ggactcgtac aggaattcgg gcgtacaaga gtgctggaca ctccgatttc 724861 tgaggcaggc tatatgggag cggctatggc tgcggcatca accggtttga gaccgattgc 724921 cgagctgatg tttaacgatt ttatcggcac gtgctttgat caggtgatca accaaggggc 724981 gaaattccgt tatatgttcg gcggaaaagc gcaagtgccg attaccgtcc gcaccacata 725041 cggagcaggg ttccgggccg ctgcccagca ttcacaatcg ctgtatggcc ttttcacgag 725101 catccctgga ctgaagacag ttgttccatc caatccgtat gatgccaaag gtcttttgct 725161 tgcagcaata gaagataatg atccggtgtt tttctttgaa gacaaaacgt cctacaacat 725221 gaagggcgag gtgccggaag attattatac aattcccctc ggaaaagcgg atatcaaacg 725281 cgaaggcaat gatgttacgc tctttgcagt cggcaagcag gtcaatactg cgcttgaagc 725341 ggctgcacag ctttcagaga ggggcatcga agccgaggtc cttgatcccc gcagtctgtc 725401 tcctctggat gaggatgcga ttttcacatc gttagaaaaa acaaaccggc tgatcatcat 725461 tgatgaagcc aatccgcgat gcagcattgc cacggatatt gctgcgcttg tcgctgacaa 725521 gggctttgat ttgcttgatg cgccgattaa acggattaca gcgccgcata caccggttcc 725581 gttttcacca gtgcttgaag atcaatattt gccgacacca gataaaattg tcagcgtcac 725641 gcttgaattg cttggcgagc cggcattgaa ttaaaggggg gacacaaatg gcggtaaaag 725701 tagtgatgcc aaaattggga atggccatga aacaagggga agtatcgata tggaataaaa 725761 aagtaggcga cccggttgaa aagggagaaa gcattgccag cattcaatcg gagaaaattg 725821 aaatggagat cgaagcgcct gaaaaaggaa cgctgatcga tatcaaagtg aaagagggag 725881 aagaggttcc gcccggcaca gctatctgct atatcgggga cgccaatgag tcggtgcagg 725941 aagaggcggg ggcgcctgtt gctgaagaca atatgccgca agccgtccag cccgtcaaac 726001 aagaaaacaa acccgcagcc tccaaaaaag atcgaatgaa aatatctcca gtcgccagga 726061 aaatagcaga aaaagcagga ttagacctaa aacaactgaa aggaactgga ccaggcggac 726121 gaatcgtgaa ggatgacgta acaaaggctc ttgctgaaca gaaaaaagat caagcaaagc 726181 ctgtttcgga gcagaaagcg caggaaatcc cggtgacagg catgagaaag gtcatcgctg 726241 cccgaatgca ggaaagcctg gcaaacagcg cgcagctgac gatcacgatg aaagctgata 726301 tcaccaagct tgccactctt caaaaacagc tttcaccaac tgcggaagag agatacggca 726361 caaaactgac gatcactcat tttgtctcaa gagccgccgt tctcgctctg caagctcacc 726421 ctgtgctgaa cagcttttat caaaatgagc gcatcatcac acatccccat gtgcaccttg 726481 gtatggctgt agccttggaa aatggcttag tggtgcctgt catccgccat gctgaaaagc 726541 tatcgctgat tgaactggct caatccatct cagaaaatgc caaaaaagca cgcgagggac 726601 gtgcgggaag cgaagaactg caaggatcta ctttctccat tacaaacctt ggcgcgtttg 726661 gagttgagca tttcacaccg atactaaatc cgccggaaac aggcattctc ggcatcggag 726721 caagctatga cacaccggtg tatcaagggg aggagatcgt cagaagcacg atcctgccac 726781 tcagcctgac atttgatcac agagcgtgtg acggcgcccc tgccgctgca ttcctgaagg 726841 cgatgaaaac atatttggaa gaacccgcag cattaatttt ataggaaaag caggtgaaaa 726901 cgacatgaca ttagccatta tcggcggcgg acctgcaggc tatgcggctg cggtttccgc 726961 ggcacagcag ggcagaaacg tgctgctcat tgacaaaggc aagcttgggg ggacctgcct 727021 gaatgaaggc tgcatcccga caaagtcttt gttagaaagc gcaaacgttc ttgataaaat 727081 caagcatgcc gacagctttg gaatcgaact tccggcaggt gcgatatcag tcgattggag 727141 taaaatgcaa agccgaaaac aacaggttgt cagtcagctt gtccaaggcg ttcagtacct 727201 aatgaagaaa aatcaaatac aggttgtaaa gggaacagcc tcctttcttt ctgaaagaaa 727261 gctcttgatc gaaggagaaa acggaaaaga aatcagagag gcggaccaag tattgattgc 727321 ctccgggtca gagccaatcg agctgccttt tgccccattt gacggcgaat ggatcctcga 727381 cagcaaagac gcgctttctc tttccgagat tccgtcttca ctagtcattg tcggcggcgg 727441 tgtcatcggg tgtgagtatg cagggctgtt cgccagattg ggatcgcagg tgaccatcat 727501 tgaaacagcg gaccggctga tcccggctga agatgaagat attgcccgtc tctttcagga 727561 gaaacttgag gaagacggtg tcgaagtgca tacttcatcc agattagggc gggtggatca 727621 aacggccaaa acggcaatat ggaaaagcgg tcagcgagag tttaaaacga aggccgatta 727681 tgtgctggtg gcgatcggca gaaaaccccg tcttgacgga ttgcagctgg aacaggccgg 727741 agttgatttt tctccaaagg gcattccggt gaatgggcac atgcagacga acgtgcctca 727801 tatttacgcg tgcggagatg ctataggggg cattcagctc gcgcatgccg ctttccatga 727861 gggcatcatc gctgcttctc atgcttccgg aagggatgtc aaaatcaatg agaaacatgt 727921 gccgcgctgc atctatacgt ccccggaaat cgcgtgtatc ggaatgacag aacgacaggc 727981 aagaagcata tacggggatg tgaagatcgg cgaattttca ttttccgcaa acggcaaggc 728041 gctcattaaa cagcaagcgg aaggaaaggt caaaatcatg gctgaaccgg aattcggcga 728101 aatcgtgggt gtctcgatga ttggcccgga tgtaaccgag ctcatcggcc aagcggcagc 728161 gatcatgaat ggtgagatga cggcagatat ggcggagcat tttatcgccg cccatccgac 728221 tttatcggaa acattgcatg aggcgctgtt aagcacgatc ggccttgcgg tacatgcata 728281 ataaaggaaa aagcaggcgc atggatataa ggcgcctgct tttttattgt tgaaagcgct 728341 ttatttttcc cctacaatag atgaaaacgg cgtgtaaggg aggagcgatc aaggaaatga 728401 attcggtccc aaacgatttg caaacctgga aacgttttgt gaaagacggt gtgcttgacg 728461 aagcccgatt aagaaaacgg attgcagagt catggcatcg ctgcaaaaaa gctgaggtca 728521 atccttattt agaaaaaggc ccgaaggttt tacagcaaac ggagctggat cagcagtcaa 728581 aaaaacattc attcttcttg acgaccgcaa agccttacct cgaaaaactg ctgcctgcca 728641 taaaagaaat ggaaatgatg gcgctgttaa ttgattcaga cggtgttgtt ctggcattgg 728701 acggccatcc gcgcgcgctc tatgaagcca aacgcatcaa tttcgtcgaa ggggcatgct 728761 ggacagaaac ggctgtcgga acaaatgcga ttggcacggc gctccacatc agcgagccgg 728821 ttgcaataca aggatcagag cattactcta tcgcttccca tctttggaac tgttcagctg 728881 ctccgattca ccatgaggat ggcagccttg cgggtgtaat tgacatatca tgcccggcgg 728941 caggcgcgca tcctcatatg cttggtattg ccacggcgat tgcctatgcc gctgaacggg 729001 aactcgcagc taaaagccgt gagaaagagc tggagctgat cagccgtttt ggggagagag 729061 ctgcatccag tgtgccgatg gtgctctgta ataccaagca gcacatcatc agtgcgagca 729121 tgccgattcg aacctcaatg ccggattggc agggccggca cctgtacgag ttgaaggaac 729181 ggggctattc aatcgaaaat gctgtcacca taggagatgg cggcacttgt ttttatcttt 729241 cggaacaaaa gaaaaagaag gcgtttcgat tcaatggagt gatcgggcaa agcggccgat 729301 cgcaagcgat gctgatgcac cttgaacgag cagctgcgac ggatgcatcg gtctgtttgt 729361 cgggtgaaac gggtacgggg aaggaggtcg cggctcgcgc gcttcatgag aacagtgaga 729421 gacggcacgg tccgtttgtt gctgtcaatt gcggagcgat tccgtctgat ttgattgaaa 729481 gcgaactgtt cggatatgca gagggcgctt ttacgggagc gaaacgaaat ggctataaag 729541 gcgcctttca aaaagcgaat caaggcacat tatttttaga tgaaatcgga gaaatttccc 729601 actcgatgca ggttgcactt ttacgggtgc ttcaggaacg caagataacg ccaatcggcg 729661 ggacgaaaga aattccggtt gatatcagag ttattgccgc cacacattgt gatttacgcg 729721 agcttgccga aaacggaaaa atcagagagg acttgtttta ccgtcttcat gtctatccaa 729781 ttgaactccc tccattacgc gatcgcaccg aggatatccc ggatctcttt gagtactaca 729841 aacagaagaa tcattggcca ggcgatcttc cttctgattt ttgtaatgtg ctgaagcaat 729901 ggaagtggcc ggggaatatc cgcgagctgt ttaatgtgtt tgaacgtctt tctatcagat 729961 ttccggacgg ccggctgaga gatgaatcgc ttcccgcttt actggaagcc gctggattgc 730021 cggccagctc tgcagaaaaa aagccggctg ctgccggcgt gcttactttt cgtgagcaaa 730081 tccaaaagga tatgatgatc aaagcgcttg aatctgcaaa aggaaacgtc tctcaagccg 730141 caaaaatcag cgggatcccc cgaagcactt tctacaaacg cctgaaaaaa ttcaacttgt 730201 ccgctgaatc ataaagcata cttccttcag gaaatggaaa cgttatgtat tgaaggaggg 730261 tgttacgatg aatattcaaa gggcgaaaga aattgtagaa tctcccgaca tgaagaaagt 730321 aacatataac ggcgttccta tttacattca gcacgtaaat gaagaaactg gaacagcaag 730381 aatttatccg cttgacgaac cgcaagagga gcatgaagtg cagctgaaca gcttaaaaga 730441 ggattaaaca aaaatggccc gcttcataag caggccattt tgttatccgc gcggcgcaaa 730501 taaaataaca cagacaccga tgagacaaat gaatgcgccg atccagtcat acagatcagg 730561 tgttttccgg tcaacaagcc atccccacag gaccgcaagc acgatgaata ctccgccata 730621 agcggcgtat acacggccga aagatgggaa ggactgaaac gtcggaagaa tgccgtatac 730681 aatgaggatc agcgccccgg cgattccgta gccagctggc tttgcctctc tcagccatag 730741 ccaaaccaga tatccgccgc caatttcagc aagccctgcc gcgagaaata aaagaatggt 730801 aatcagcatc atgagcactc ctcaatttgc atttatcttt cattatagag gaggagagct 730861 tttaaagctt cggatgattc tcaaattcct tcaaatacgc ttttcgctga acctctgtaa 730921 attggctgat ccaattgttt tgagcctctt cattcaaatg gggaaggata tagcgttcaa 730981 ccgcttcgaa aaacagcgga ttcgtgatga tgttccaggt cgggattcga acgattttgc 731041 cgtctgtttt ctcgatgata atatcctcaa aaaagatccc tttcaaactg tattgatggc 731101 gtcccatata aagccgcttc acctcggaaa acagcacgct gcgctttctc aagaagattt 731161 cgccactagg tccggtcttt atggtgaaaa tgacatttcc acggcttgtg aacgcaggaa 731221 aagccataaa gaatgtgatc aatccataaa tcatcgccag taatccgccg cccaaataaa 731281 gcagggcata tttagattca aacgtgaggg cttcagacac cagccagact cccacaataa 731341 aggcgccccc tgtagcgagg aacagccaag cccttagaaa catcatgctt tttacttcaa 731401 tcatgtgctg cccctaaagc ttcggatgat tctcaaattc cttcaaatac gcactgcgtt 731461 ggatgtctgt aaactgtccg atccaattgc ttttcgcctc ttcattcaga tgtggaagga 731521 tatagcgttc aaccgcttcg aaaaacaacg gattcggaat gatgttccaa gtgggaatgc 731581 gaatggtctt ctgatccacg gtttggatca atatatcttc ttggaagatt ccttttagac 731641 taaatttatg gcggctcatc tcaattttct tgatatcagt aaacgtaaca gacactttgt 731701 cagtgaacac ttctccattt tttcctgtct tgatgcggaa aatggtattt ccccgcgggg 731761 tgaaagccgg aaagaagatg ataaataaat ataaacaaaa caaggtgaac agaaagccag 731821 caggaatggc taataggtaa tatttcgttt gaaacgtaat acccatataa aagagccaca 731881 aacatgctaa tcccataccg gcagatccga caaaagccca tattctcagg aacattttgc 731941 ttttgacttc aatgatttct tggtttttca atgcttttct ccttttgtta attcaattct 732001 tatcattttg aaatgatttg atttacaaca tccttatgag cagggaggat agaaaattca 732061 ttctgggtga tgcctgtgac aagccaagta tggtgggccc ccggcaggac gaatgccatg 732121 tcagccactt caggagtgtt atcttttcca tatgccagac gcataagtgt atccattttc 732181 cctttccgca aagccagatc atttgcaaat cgggtaacgt cctcttggtg gtcatgtttt 732241 tcaaggaact cttttagata tgaagggttg tctgaagcgc cctccaagag tttttcaaat 732301 tcatttgatg tcaatgttac aatcgattct cttttatcct ctgtatctat tatatgtaaa 732361 aactcatctg tcttagcaag taacccttca cttgattcca tttttgtaat gcgatggact 732421 tgttcatcaa aaaggagttc gtgagagtag gtgccgaatt ttgatacatg gcatgacaca 732481 ttctgttcgg caccttgccc gttaaattta gaaagcttca ctgtatagtc agcgtcgttt 732541 aatacatgga taaacggaca gtactcgtcc tttaaccgat attgatggtt ccgatattcc 732601 gctgcatcct tggctaagag tgagcggcac gcggcttcaa ataaggcgcc gagctgttca 732661 tcttctattt ccggaaaata ggcctgcttc aaggccattc cctgttcaaa aaacccttcg 732721 ctgtaaaagc aaaacaagag ttcttctatg ctaattgtaa actgcttcat tgtttattct 732781 cctatccaaa tgaaaatttc cctttaagga aatgggttgc gccgtgtata agcgaatccg 732841 ctgttttctt tgctttttcc attccttttt tcgcgctgtc tatcccttta tgtatcgatt 732901 tattcgccgc atctatgccg tcattcactg atttgacgac tttgccggct gattccagcc 732961 cttttttggc tgtatcaaca acagcatgga tcggttcttt cagctttaag gctgcttttt 733021 cagcaaaacc ggctgtatat ttggcgattt gttctccgac gactccgcca atgtatgaac 733081 ctgctgcccc aagaaggaca gtacccacag gtcctgcaaa gcttccgatt gcaccgccga 733141 tgacagcacc agctgtggca ccgccggcaa caaaaatcgt attattcaca gcattcccga 733201 cggccttggc gttttcacgc ttgagaactt ccggtttatc ctggtatttt gcataatttt 733261 cagcaatttt cacgcctgct ccgaatgttt cggtcgctcc ggtaatcagt gtggcggtaa 733321 tggcatttcc tttcgcgaat ctcaagcccg tttttcccac atccttcaaa gtggagcgta 733381 cgccggcttc attaagaaat ccttttgtgt agcttctgac gctgtttgaa aaatccaccg 733441 tgtcctgagg aaagtatttt gtaaactttt tatgtaccaa atctgaaaat ggacggtttg 733501 tctttttcaa caaatattta ggattcaaaa gcactcttgc cgctttttga taacgtgagc 733561 tgtcaacggc cctggaaata tccaagagca gttttgagtg ctgggctgta tgcaagccgc 733621 ttggttgttt cacaaatttc gtaagcccta atccgtaata ttttccctgc gtcagcataa 733681 gagcggttaa gcttgtcatc gtaccgtatt tgtcgtaggc attgtagagc tttcgcaaaa 733741 tatcatcttg ttccacaaat ttatcgcctg tttttctgat gaaaatctca ttgtcactca 733801 gcttagtgac gagcgccttt cctgagctcc acgcatcgcc cactccagaa aaacagctgc 733861 tgtagcgggg atcgcattgc aaaatcatct gccccagctc cacatgcagg tccttatatt 733921 tgttttccat atcagttaat tcagtgacta catcatttgc aagctgttcg agcttatccg 733981 gatcaactgc aatgtttcct gacacaccgt tcacctcccg agtttatgtc tttcctctct 734041 tgctttacgc tccagttctt ccattctggc aatttcagct tttcgttctt ctattttgac 734101 agcggcagcc ttcagctctt ggcttgtttc aagcagctcc tgttcgaatt gatcgtaggc 734161 ggctttcgtt tcctcgaaat cctggtcaaa cgaatctctt gctttgccct gccaagcatc 734221 tcccaatgca gataaccggg attcaagcag cattttggag cttctgacct cttctgcggc 734281 cgcactatac ttgtttgcca gctcaatgac tttatatgag tccaactttt gtcccctgcc 734341 ttttctaaat tcacgcacaa ttggatgttt tatataaatg attataaata attcggcatg 734401 tatccgaatc gtacaaaaga accttttcat aagaattgga agggcgtata ttcacttaaa 734461 attcacagtt ggtgagactt taagattaca aaaaaggtaa aaaaaccaaa tctctcagac 734521 ataaggcaaa tgagaaattt cccgctctat gggaaaaaac actaaagttg atcaaatgac 734581 ctaagtgcgc caaacgtgtt acgggacgag ctatctcatg gtataaatgg aattgtaaac 734641 gttatcaagg aggtcgtcat atgaagaaaa aatcattctc aatcgtaata gcgggcggag 734701 ggagcacttt cactccaggg atcgtactca tgctcttgga ccatttggag gagtttccga 734761 tcagaaagct gaagctgtat gataatgata aggagagaca ggatcgaatt gcaggcgcct 734821 gtgacgtttt tatcagagaa aaagcgccgg atattgaatt tgcagcgacg actgacccgg 734881 aagaagcttt tacagatgtc gattttgtta tggcgcacat cagagtaggg aaatacgcga 734941 tgcgcgcgct tgatgagcaa attccgttaa agtacggagt tgtcggccag gagacgtgcg 735001 ggccgggcgg gatcgcatac ggtatgcgtt cgatcggcgg tgtgcttgaa atattagatt 735061 acatggaaaa atactcgcct gatgcgtgga tgctcaatta ttccaatccg gcggcaattg 735121 tggctgaagc tacgagacgc cttagaccga attctaaaat tctcaatatc tgtgatatgc 735181 cggttgggat cgaagaccgg atggcgcaaa ttcttggctt atcctcaaga aaagaaatga 735241 aggtccgcta ttacggattg aatcatttcg gctggtggac atcgattcag gatcaagagg 735301 gcaacgattt aatgccgaag ctgaaggaac atgtatccca atacggttat attccgaaaa 735361 cagaggctga agctgtggag gcaagctgga atgacacgtt cgccaaagcg cgtgacgtgc 735421 aggctgcaga tcctgacaca ctgccgaata cgtatttgca atattatttg ttcccagatg 735481 atatggtgaa aaaatcaaat ccgaatcata cgcgggcgaa tgaagtcatg gaagggcgcg 735541 aagcttttat tttcagccaa tgtgacatga tcacacgtga acagtcctcg gaaaacagcg 735601 aaattaaaat cgatgaccac gcatcgtata tcgttgatct tgcccgggcg attgcctaca 735661 acacaggtga aagaatgctg ttgattgttg aaaataacgg tgcaattgcg aactttgacc 735721 cgactgcgat ggttgaggtg ccatgcatcg tcggctcaaa tggacctgaa ccgattaccg 735781 ttggcaccat tccgcaattc cagaaagggc tcatggagca gcaggtatcc gttgagaagc 735841 tgactgttga agcgtgggca gagaaatcgt tccaaaagct gtggcaggcg ctgatcctgt 735901 caaaaacagt gccgaacgcg cgtgtggcaa gactcattct tgaggattta gtggaggcca 735961 acaaagactt ctggcctgag cttgatcaaa gcccaacccg catatcataa atgaaattcc 736021 cccattttcg aatctgtaat tgtatataat agaaagaaaa tggggggatc tgatatgcag 736081 ctcgaagaac tgatcaatca gcactacagc aaattgaatg acaacgattt tcatatttta 736141 aaatatatat tgaatcataa gcacacatgc tatcaccttg gaatcgacgc gctggccaaa 736201 gcttgcagtg tatcgcgttc ctcaatttta cggcttgccc aaaagctcgg tttcagcggt 736261 tacagtgaat ttcgcgtctt tttaaagtgg gaagatcagc cggaagaagg cgagagtatg 736321 agttttgaaa agctgcttga tgatattgaa gcaaatttga agtttttacg gacaaaggac 736381 atgacggaca tgtgccagct gattgatgca gctgaccgca ttttcgtcta cggttctgga 736441 aatgcgcaaa agatatgcgc ccgcgacctg caaagaatgt ttattccgcg ccatcgctat 736501 cttattttga ttgaagacac aaatgaattt aatttgatgc gcgatgattt taaagtgaac 736561 gatctgttta tcatcatttc tctttccgga gaaacaccgg agctgattcc tcaggcaaga 736621 atgctttctg caaagggtat tccctttatt tccattacga atttaaaaaa caatgtcctc 736681 gcccagctga ctccgcataa tctttatgcg acaagcaaac ctgtgacatt aagcgataga 736741 acggaaattg tcgcttttgc accgtttttt ctcgttggcg aagcattgtt ccgcgcatat 736801 gttgattaca aagaggcaga aaaaaatgac aatgagtagc agggggttct ggtatgatgc 736861 aaaaaattca gcgctttgga agcgcgatgt ttgtgcctgt tttattattc gcgttcgccg 736921 gcattatcgt cggtatcagc acgctcttta aaaataaaac cctcatggga ccgctcgccg 736981 atcctgacgg tttttggtat cagtgctggt atatcattga gcagggcggc tggactgttt 737041 ttaaccaaat gccgctctta ttcgccattg gcatcccggt tgctttggcg aagaaagctc 737101 aggcacgcgc ctgtttggaa gcgcttactg tctacctgac attcaactat tttgtcagcg 737161 cgatattgac ggtatgggga ggagcatttg gcgtcgacat gaatcaagag gtcggcggaa 737221 cgagcgggtt aacgatgatt gcgggcataa aaacgctcga taccaacatc atcggagcca 737281 tctttatttc ttcgattgtc gtctttttgc ataatcgcta ttttgataaa aaactgcccg 737341 attttctcgg catctttcaa ggctcaacat atatcgtgat gatttccttc tttattatga 737401 tcccaattgc gttggctgtg tcttatattt ggccgatggt tcaatcggga atcggctcgc 737461 ttcaaagctt cctggttgct tctggggcgg tgggcgtttg gatatacacg tttttggaac 737521 ggattttaat tccgaccggc cttcatcact ttatttacac gccgtttatt tatggcccgg 737581 ctgtagcgga aggcgggatc gtcacgtatt gggcacagca tctcggcgaa tattcgcaaa 737641 gcgccaaacc gctgaaggag ctctttccgc aaggcggatt cgcgcttcac ggcaactcga 737701 aaatcttcgg tattccgggt atcgccctgg ctttttatgt gacagccaaa aaggaaaaga 737761 aaaaactcgt cgcagggctg ctgattcctg tcacactgac agcgattgtc gccggtatta 737821 cagagccgat tgagtttacg ttcttattca tttcaccttt cttatttgcg gttcacgccg 737881 tgcttgccgc cacaatgtcg acagttatgt atatggccgg cgtcgtcgga aatatgggag 737941 gcggactgat tgaggcggta accttgaact ggattccgct ctttggcagc cacggtatga 738001 catatgtgta tcaaattttg atcgggctct cgtttacagc aatttatttt ttcgtcttca 738061 gatttttaat cctcaaattc aatatcgcta caccaggacg ggaaaaggat gaacagcagg 738121 aaacaaagct atattcgaaa aaggaataca gagaacgaaa aaacaaggat gaaacggcct 738181 ccgctgctga aacggctgat gacaccgctt ttctgtatat tgaagcgctg ggcggaaaag 738241 acaacatcac tgaagtcaca aactgcgcca cccgcctcag agtcagtgtc aaggatgaaa 738301 caaaggttga acccgacagc gtattccgcg cgcttggcgc acacggcgtt gtcaggaacg 738361 ggaaggcgtt tcaggtaatt atcggattaa gcgtgccgca gatgcgggag cgtgtggaaa 738421 aaatattgaa tcaataaaga ctgccctcct tttcgggagg gttttcgttt gccgtcaaaa 738481 agaccgccat agtaaagtaa agaaagagac aatcgagtaa aaaggggttt ggaggctttt 738541 acatgcaaaa ggctttgtcg tttttaaaac catattcatt gctggcggga attgctctga 738601 ttcttatgct gacggagctt gcagttgaac tgatgcagcc tttattgatt gcaaaaatca 738661 tcgacgatgg gatattgaag caagatctgc ggcatgtatg gatatggggc acggtcatga 738721 tcgggctgac cgtgttatcc tttgcggcgg ggatgctgaa ttccttttat gccgcccatg 738781 tcagccaaag cttttcctat gatacgagaa aagggctttt tcaaaaaatc cagtccttct 738841 cctattccac atttggacag ttttcgtcct cttcttatat tacaaggctg acaaacgacg 738901 tcacacaggt tcaaaatatg atttttatga gtttgcggtt tatgctgcgg gctcccttaa 738961 tgattgcagg cggcattgtg ctgtcgcttg ccgttaatgt gaaactcggg ttttttctgc 739021 ttgtgaccat tccgatcctg atcttgtttt tgctatgggt attaaggaaa ggcggggcac 739081 tgttccgctc agtgcagaaa aggctggatc aagtgaacac catcatgcag gaaaatttaa 739141 ttgcaatcaa gctgatcaaa gcgctgcttc gcggcagcca cgaagtcaaa cgatttatca 739201 aagccaacac aaggctgatg gaaaaaacgg tttcggcctt tcagcttgtg gaattcacga 739261 tgcctgtact gatgctgctg atgaatctct gcatcctttt gattttgtgg gcggggtcct 739321 acagtattac gagcggaagc actcaggttg gcgatgttgt tgcgataatt aactacgcaa 739381 cacgaattac aggcgcgctt tcgatgtttc cgtttttgat tatgattttc acccgggcga 739441 aggcttcagg ggatagaatc ggtgaggtgc ttgaaacaga aggcgacgag cgggaggaag 739501 gcaccatatc tgatcgtttg tcaggacgga ttgagtttca gcatgtatcc tttcgctatc 739561 ctgaaatgga cagagaagcg ctcaggaatg tctcattttc cgcaaagcca agagaaacga 739621 tcgcgattct cggtgcgacg ggctcgggca agtccacgct ttttcagctc attccgcggc 739681 tttatcagcc ggattcaggc cgcatttaca tagatgaaaa gccggttcaa gatattccgg 739741 ctgaagggct gcgcaggcaa attggatatg taccgcagga agtcctcttg ttttccggca 739801 caatcaaaga aaacatcgct tggggcaaag aaaatgcttc actagatgaa ataatggatg 739861 cggcaaaact tgcgcaaatt catgaaacga ttttaaagct cccaaatgga tatgacactg 739921 ttttggggca aagaggcgtc aacctgtccg gcggccaaaa gcagcggatt tccattgcgc 739981 gggcgctgat tcgaaaaccg gctatccttc tattagatga cagcacaagc gcgcttgatc 740041 tgcaaacgga ggcgaagctg cttgaagcaa tcagcacata ccattgcaca actttgatca 740101 ttacacaaaa aataaccacg gcgatgaaag ctgatcagat tttgctgctt gaggacggcg 740161 aactgattga aaaaggcact cacagtgagc tgctttctga atctcagtta tacaagcgca 740221 tttacgagtc acaattcgga agggagggga gcgagtcatg ctaaaagaca tccgcaagcc 740281 tttccaatat cccaaactgc caattgacaa aaaagaaggc gcgaaaaagc gggcgaaagc 740341 aaaggataca aagggcacac tgagacgaat ctggtcttac ttggctgaaa gaaaaggact 740401 gctcatactt gtcatgctaa tggttgtcat cagcgccata ttcggactcc ttggtccctt 740461 tgtgatcgga aaggccatcg accattttat cgtcgggaaa acggtcagcg gcttgattcc 740521 tgttttgctt cttctgctcg ctatctatat cattcagtcc ctgtcgcttt ggtttcaaaa 740581 ctattggatg attacgatct cgcagggcac ggttttcaga atgagaagcg aattgttcac 740641 ccatctgcat gagctgccga ttccattttt tgataaacag cggcacggcg agctgatgag 740701 ccgggtgacg aatgacatcg aaaatgtcag ttctacctta aacacgtcag tcattcaaat 740761 tttgtcaagt gtgatcacct ttgtcgggac gattgcggtg atgctgtaca tgagcccgct 740821 ccttactttg attacgctga ccattattcc ggtgatggca gcgagcctga aatggatcac 740881 caaccgaacg ggaaagctgt ttaaagaaca gcagaaaaac cttggtgatc tgaatgggta 740941 tattgaggaa tctgtttcag gcgcaaaggt catcaaagca tattcacgtg agaagcagat 741001 tactgctgaa ttcctcgaaa aaaacgctgc actcaagacg tcgggctttt gggcgcagac 741061 gatttccggg tttattccga aggtcatgaa ctctttgaat aacttaagct ttacaatgat 741121 tgcggcaatc ggcggtttgt ttgcgctgaa aggctggatc tcgatcggct ccatcgttgt 741181 ctttgccgag tattcaagac aatttacacg ccctttaaac gatctggcca accagtttaa 741241 tacgatgctg tccgcaatcg ccggcgctga acgggtgttt gacgtgcttg atgaaaaaga 741301 agagcgcgag gatgaaaaga acgccgtgca tcagcccatc caaacaggca gcattgaatt 741361 ccgggatgtg tccttcggtt acgataaagg gcagcagaca ctgaagcatt tacagtttac 741421 cgtgcctgcg gggcagtcca tcgcgtttgt aggaccgacg ggggcgggga agacaaccgt 741481 cactaacctt ctcgcccgtt tttacgagcc taacgatgga aaaattttaa tcgatggtac 741541 agatattaaa acccttacta gagcaagcct aagaaaaaac atggggtttg ttcttcagga 741601 ttctttctta tttcagggaa cgatcagaga aaacattcgc tacggcaggc ttgatgcttc 741661 tgatcaggaa gtcgaagccg ctgcaaaaac agcgaatgcc catagtttta ttgaaaggct 741721 gccaaaaggg tatgacaccg tactgacgca aaacggttcg ggcatcagtc aagggcagaa 741781 gcagttgatt tctatagcga gggcggtgct tgccgatccg gttcttctca ttttggatga 741841 agcgacaagc aacattgata ccgttacaga agtcaacatt caagaagcgc tcgcccgttt 741901 aatggaagga agaacaagcg tcatcattgc ccacaggctg aacaccattc aaagagcgga 741961 ccagattgtg gtgctaaaaa acggtgaaat gattgaaaaa ggcagccatg acgagctgat 742021 tcggcaaaaa ggattttaca gtgacttata tgaaagccaa tttgagaaat agacctttgt 742081 cctgcacaga ggtctttttt tgttacagtt ttatagtact tttatttcat tttcgtaaaa 742141 tgtaacaaaa ttacttgacg taaacaagtt atgtatatat actagcttac attaagtaag 742201 tgataacatt tatcaaggag gataaaatga ataaatcatt tgaaattggc acattacttt 742261 taagagttat tacaggtatt atcttttttg ttcacggttt atcaaagttt cagggaatgg 742321 agggcaccat ccaatttttc ggcagcatag gccttccaag ctttatggcg tatgtcatcg 742381 cagcgattga actgattggc ggagtgcttg tcttcttcgg attggctaca cgtattgtcg 742441 gtgtactgtt cgctcttaca ctgatcggcg ccatcatcac tgttaagctg aaagcgccat 742501 tcatgggcaa tgcagaattt gattaccttc tgcttttgac atccattcac ctggcgctta 742561 ctggaagtcg attcctggcg ctggacccat ttgtgtttaa aggaaaaaag aacggaaacg 742621 tttcagcata agaaaagagg catgcagcat gaccagcatt catgaggata cacacattgg 742681 ctatgccaaa ctcacaattc gcagtctgga gcgttcgctt cagttctact gtaacgtcat 742741 cggttttcaa gtcttaaaaa agacggaccg ccaagcggaa ttaacggctg acgggaaacg 742801 cgtactgctt attcttgaag aaaatccgag cgctgtcgtc ttgcctgaac ggtctgtgac 742861 aggcctttat cactttgcga ttcttcttcc ggacaggaaa gaacttggga tcgcgctcgc 742921 ccgcctgatt gaacacggca ttgctatcgg acatggagac catgctgtca gcgaagcgct 742981 ctacctgtct gatcctgacg gaaacggcat tgaaatgtac gctgaccgcc cccgcagcac 743041 gtggcagcgt gatcgggaag gaaactacgt catgacgaca accgctgttg acattgaggg 743101 ccttctggaa gaggcaggag atgagcggaa aacatcgctt ccgaacgata caatcatcgg 743161 acacattcat ctgcatgtca gtgatttgaa agaagcaaag gcgttttata cagatgtact 743221 gggctttgac attgtcggaa actatgcggg catgtccgcc ctcttcgttt cagccggggg 743281 gtaccaccat catatcggct taaacatttg ggcgggaaga aatgcgccgc ctaaaccgac 743341 aaatgccagc ggactagatt attatactgt tgtcctgccc caccaagagg agctggattt 743401 ggtggcaaac cgagtcaaac atgccgggta ttcgattgaa gagacggaaa acagctttcg 743461 tgtgaaagac cctgtttccg gcgcctatat tacatttgtg atttaactgc aatccccttg 743521 ccgaaataac ggcaggggga ttttttattt ttgtccgcct tgttatgatg agagaaccaa 743581 cttgttagga ggcgtttaca tggaactcaa ccaccttgtg acgggcaaaa tagcattaaa 743641 tcaatatgtg catcgcttag agcaaaagga tgtttcattt tacgtccact actggggagc 743701 gatgacgaac cactataaca cactgcttca taagcattcc ttttatgaaa tttgttacgt 743761 ggtaagaggt gaaggatatt accttgaagg cgatcgtaca tatccgcttc gtgaacagac 743821 gatttttttg tcaaagccgg agcatttgca ccaaatcaaa agtgaaacag ggctgttcct 743881 tttttacgtc gctttcgagc tgagcgagga tcagtcaagc gccgaatgga tcaaagtgat 743941 ggaagaagtg aaacaaagcc cctttatcac aatgcaattg aaagatggcg aaccgccggg 744001 cctgctttgg aaaacgttaa tgctgcaagc agcgcaacct gtcaatgctt ttgacaaaga 744061 gatcctatct catttgtcgc atgcattgat cctgtcatta atccaaacct ttctcccgta 744121 cgcccaacgc ccgaaacaaa agcagcccat tcacacatct tctgctttgc tgacagaggt 744181 gaaactgcac ataaaagaca atctgtcaca gccgttaaag ctgacggatg tcgctagcca 744241 ctttcatatc tcagggaggc atttatcacg tttatttgca gcagaactgg gcgtcagcta 744301 ctcagaattt gtccaaaatg aaaaaataaa caaagctgcc gaactgctga aatcaacgaa 744361 tttgtcgatt aaagaaatag cggaagaaat cggtttctca gtacattatt tcactcgcgt 744421 cttttccgct aaaatcggca gctctccagg gcttttccgc tccctttata aagactcaaa 744481 aatgaccgca tttcaaatca ataaaccttt tcaaaaaatc gaacaggcca agccgcacga 744541 ataagatgtc ctgaaatgac aaaacaatgt cttcatatga taaagacgcg agaaatctcg 744601 ttgtcttata atctttttag aaagcggtta caacaagggg tattgctgaa ggagggatgc 744661 attggcttat gcttggtgtc gggtgctctg ccattcttga aagaagggga agaaagccgt 744721 gagtacaaaa aagaaagagg ctgtaatagg aaaagaaagc ttagctcata aagggctttt 744781 acgaacgatt acattggtat ctacattcgg cggcctgttg ttcggttatg atacgggtgt 744841 cattaatggg gcacttcctt ttatggcaac tgcaggtcag ctgaatctta cacctgttac 744901 agaaggactg gttgcgagtt ccctgcttct cggggcagcc ttcggggcga tgtttggagg 744961 acgtctgtcc gatcggcacg gccgccgaaa aacgatcctt tatttagcct tactcttcat 745021 cgcagccaca cttggctgta ccttttcacc aaacgcgtcc gtgatgattg cctttcgttt 745081 tctgcttgga ctggcggttg gctgcgcttc tgtaacggtt ccaacctttt tagcggaaat 745141 ttcgccggca gaacgcaggg gacgaatcgt gacacaaaat gaactgatga tcgtaattgg 745201 ccagcttctg gcatacacct ttaacgccat tattggcagc acaatggggg agagcgcaaa 745261 tgtatggcgg tatatgctgg tcatcgcgac acttccggct gttgtgttat ggttcggaat 745321 gctcatcgtg cctgaaagcc cgcgctggct ggcagctaaa ggcagaatgg gtgacgccct 745381 gcgggtgctt cggcaaatcc gtgaagacag tcaggcacag caggaaataa aagaaatcaa 745441 acatgcgatt gagggcacag caaaaaaggc cggctttcat gattttcaag agccgtggat 745501 aaggcgcatt ctattcattg ggattggaat cgccatcgta cagcaaatta ccggtgtcaa 745561 ttcgattatg tactatggga cagaaattct gagagaagcc ggttttcaaa cagaagctgc 745621 attaatcggc aatattgcaa acggtgttat ttcagttatt gcggtcattt ttgggatatg 745681 gcttctcggc aaagtccgtc gccggcccat gctgatcatc ggacagattg gcacgatgac 745741 agcccttctg ctgatcggga ttttatccat tgtccttgaa ggaacacccg ccctgccgta 745801 tgttgtgctg agtttgacca ttttgtttct tgcgtttcag cagactgcca tttctacggt 745861 gacgtggctg atgctctcgg aaatctttcc tatgcatgtg cgggggcttg gcatggggat 745921 cagcaccttc tgcttgtgga cagctaactt tctcattgga ttcacctttc ccattttgct 745981 caatcatatt gggatgtcgg cgacattttt tatctttgtc gctatgaata tcctagcgat 746041 tctatttgtg aaaaaatatg tgcctgagac aaaagggcgg tcacttgaac agcttgagca 746101 ttcctttcgc cagtatggcc gccgcgctga tcaggaaatc caaaatcaaa caactcactt 746161 atcgtaacct gagataccag gaggaatcta tcaatgaaac tatcttatgt aacagacagc 746221 ctagggcatt tgccttttga agacatgctc aattttgccg caaagcttgg gatcgataca 746281 cttgaaatga caaccggggg ctggtcgccg gcacctcact tgaatcttga tgaattgctg 746341 caaagcagcg aaaaaagaaa agaattttca caagcgctgg aaaagcggaa catgacactt 746401 tgcgcattaa actgctcggg gaacccttta gatccgggtg aattgggcaa atcgcacaga 746461 gacataactg acaaaacgat ggagctggct ggattattag gcgtcaaaaa agtgatcatg 746521 atgagcggtt tgccagccgg cggcccggac gacaaagtgc cgaactggat cacatacaca 746581 gtaagctggc ctcccgtttt aaaagatatc ctcaactatc aatgggaaga cgttgcgatc 746641 ccatattgga agaagcttgt caaaaaagcg gaggcctgcg gcgtggggaa aatagcgctt 746701 gagaacttca gctctcaatt agtctataat cctgagactc tctttcggct cagaaatgca 746761 gtcggcccga tggtcggttt gaatcttgac ccgagccatt tgttatggat gggcgcagac 746821 ccgatcatcg cagcaaggga gctcggctca gccattcacc atgtccatgg gaaagatgtc 746881 agaattgaaa gatatttatc ggcggtcaac ggacttttag aaacaaaaga agtgacagat 746941 cctgcaaacc gggcgtggaa ttacgtagct gtcggctgtg gacaggattt acagtggtgg 747001 aaggaatttt tttcagttgt aaaaatgatg ggatatgaag gtgaggtttc tttagaaatg 747061 gaggatctga cgatgtcacc tgaagcgggc atccgtactt ctgtagaagc tttaaaacaa 747121 accatcagcc aataggaggt tttcatgatg ctaaatggag aaagaatcat ctctaagccg 747181 cttcgctggg caatggtagg cggcgggcgg ctcagccagg ttggatataa acatcgtatt 747241 ggagcgctga gagacaatac tgcttttcaa ttaactgctg gcgcttttga tatcgatgcc 747301 gaaagaggaa aagatttcgg ggtgaacctt ggagtggatg cggaacgctg ttatcccaac 747361 tatcaaacca tgtttgccga ggaagcgaaa agacaggatg gcatagaggt agtatcgatt 747421 gccactccga acggcactca ttatgagatt tgtaaggcgg cgcttgaagc aggagtgcat 747481 gtcatctgtg aaaaaccgct gttcttcact tcagcagagg ggcaggaaat caaagcgctc 747541 gcagagaaaa aagggaaaat tgtcggcgtg acgtacggtt tttcaggcaa tcaaatgctt 747601 cttcaaatgc gtgcgatgat tgaacaagga atgatcggcg atattcgcgt ggttgacttg 747661 cagtacacac acggtttttg tgcaacagat gaaggtgaaa agataagcgc tgcacagaaa 747721 tggcgtgtcg accctgcgat cgccgggcca agctttgtgc tgggcgattt atctacccac 747781 acgtattata tgtcacagct tattatgcca aagatgaaaa ttaaggagct gctgtgtgac 747841 cgacagagct tcgtcggcag ccgcgcaccg ctagaggata atgcccatgt gctgatgcat 747901 tatgaaaatg gagcggtcgg aacgatgtgg acatcgtcaa tcaatgccgg atgtatggat 747961 ggccatagaa tccggattgt cggctcaaag gcaagcattg agtggtggga cagcaagcca 748021 aatgaactga cgtatgaagt gcagggagag ccgggccaga cactcgttcg cggcatgccg 748081 tatttagatg atgtttgcaa cgccgatgaa cgactgggcg ccttacacag cgaagggctg 748141 tccgaagcat gggccaatat ttatcttaaa tttgccattg cgatagacgc caaaaaccgt 748201 gaagatgaag aaatcttgaa caacttggtt tatcctgaca ttgatgcagg gatcgagggc 748261 attcgctgga ttgagaactg cgtgcgctcg gcaaaccaag ggtcagtttg ggttgaattt 748321 aaataaatga gggaatgcgc cgcatatgac ataaagttca tatgcggttt ttattttcca 748381 gaaactcctg tcaaaaatgc cctgaggcag gtatgataag aagggaattg ggtatcggga 748441 gtgatgagcg tgaaagctct tttttttacg agaatgttca ccttgatggt gagctgttta 748501 atgtatctgt ccattgtgaa agaggataac tggtttggat atgtatttat agcagcaggt 748561 gctgccatgt atgcagccaa tcatgttttg ctgacaaaag agacaaatgc catctggttc 748621 tgcctgattg atattgcaat cggcttttcg ttcggattta tctttcccgg cacaggtttg 748681 ttcattatta tgctttgtcc ggttgcggtc gccttttttc tgcgggggtt tcctaaaaga 748741 acagcatggt ctgtcttatg tctttcctct attttatttt tgaccgtcct catccgtaca 748801 tatgcgatgt tcggcaatga atttgtcatt gatcatttga ctagcatgac attcgttgtc 748861 ttctgcggtg tcgtgggcaa attaatccgc aagctgttgg atgcgcagga tacggcaaaa 748921 cagcagtttc aggaactgac ggagtcccat ctggcgctgt ctgctgcaca tcaggagctc 748981 catttatatg cgaagcaggt tgaagagctg actgccattt acgagcggaa cagaatggcg 749041 cgtgaaatcc atgatacagt ggggcataaa atgacggccc ttctcgtcca gctgcagctt 749101 ttgcgtgaat ggcaaaaaag agacagccaa aaagcggatg agacagtagg tgtctgtgaa 749161 acacttgccc gtgaagcgct tgatgatgtc cgcttatcag tacgcactct gcaaactgaa 749221 aacgatcctt cgctaatcga atcgctgaaa cagctgacag aggacttttg caaaaatgca 749281 ggagtcacaa cagaatttgc ggtcagcggt gatcctgcaa tcatcccgct gtctctccat 749341 ccgaccctga tcagaacggt gcaggaagca ctgaccaatg ccaaacggca cggcggcgcc 749401 gcagcctgtt cgatacagct tgcctgcaca acggacagca tcagccttgt cattaaggat 749461 gacggcaaag gcaatcctga ggcagcactt ggttttggtc tcttgaatat gaaaaagcgg 749521 gcagcggagc atggcggaat gatccgcttt gaaagcgaac gggatcaagg atttactgta 749581 aatgcagaat tttcacttgc caataaaaaa tggagcttcg ggcccgtgca gcaaaaggag 749641 agtttatcat gattaagatc atcattaccg acgatcagga tatcgtcaga gaagggctgg 749701 catccctgct ccagctccga gaagagctcg atgtgatcgc aacggcgcga aacggacagg 749761 aagccttcga aaaggcgaaa gagctggagc cggatatcgt gttaatggac atccgcatgc 749821 cggtttccaa cggggtggag ggaacaaaat taatcacaag ctcgctgcca agcgtaaagg 749881 ttttgatgct gacaaccttt aaggattcag cgctgattgc tgaagcgctt gaagagggag 749941 caagcgggta tctgctgaag gatatgtctg cagatacgat tgtaaaagca gtgatgactg 750001 ttcattctgg cggaatggtg cttccgccgg aattgactgc ccaaatgctg aatgaatgga 750061 agcgtgaaaa acagctgaaa ggaataaatg agatagaaaa acctaacgag ctgctcgacc 750121 tgaccgagcg cgaaatcgaa gttctggctg agctgggata cgggctgaat aacaaagaaa 750181 ttgccgaaaa gctttacatt acagaaggca cagtcaaaaa ccacgtttca aatattatca 750241 gcaagctggc tgtcagggac agaacccaag ccgccattta ctcggtcaga tatggtgtat 750301 ctgtcttttg acatatgacg ttttgcatat acgcttctct gaaaaggcct tttacaggcc 750361 tttttttcat gccctatgtt ctatctgccg ctacatgccg cacgcctttc tttcttctac 750421 aatggcaatg gatcaaaaaa aggagtgaga cgacgtgctg caagcagaaa acatcaaaaa 750481 ggcatacgga aaaaaaacaa tcgtgaaagg catttctttt tccctcaaaa agggggagtc 750541 gttcggtctg ctcgggccta acggtgcggg gaaatccaca accatctcga tgatttccgg 750601 ccttgtgccg catgacagcg ggaacatcac ggtgggcggc tatgttatcg gaaaagaaac 750661 ggccaaagcg aaacaaaaaa tcggcattgt tccgcaggaa attgcattat atccgacgct 750721 gacggctcat gagaatctta tgttttgggg gaaaatgtac ggacttacgc acggtgaggc 750781 caaaaaaaga gcggctgagg tccttgaata tgtcggtctg actgagcggg ctaaagataa 750841 gattgaaaca ttttccgggg ggatgaaacg aagaatcaac atcggtgcgg ctttaatgca 750901 taagcccgag ctgctgatta tggatgaacc gactgtcggt attgaccctc aatcgagaaa 750961 tcacatttta gaaacggtca aacagctcaa cgaaacgggc atgacggtga tctatacgag 751021 tcattacatg gaagaagttg agtttttatg cgaccggatc gggataattg atcaggggga 751081 aatgattgcg attggcacaa aaactgattt gtgcagccgc cttgggggcg ataccatcat 751141 tcagctcacg gtcagcggga tcaatgaagc gtttcttgtg gcgatccgat ctctggccca 751201 tgtgaatgat gtaacagtac atgaattaga gctcaaaatt gacatttctg cggctcatca 751261 tgagaaagtc gtcacaagcc tgcttgctga agccactgct catcatataa acctgctgtc 751321 tcttcaggtg caggaaccga atctggagcg cctgtttctg aatctgaccg gccgcacgtt 751381 gcgggattga ggagggacgg caatgaaaaa aagcatatgg atcgcatgga aagatgtgaa 751441 aatcagaatc acggacagaa aagggtttat gatgcttatc ctaatgccgc tcatcctaac 751501 ctgtatttta ggcgcagcgc tcggatcagt tgttgacgga ggcagccgga ttgatgatat 751561 caaagtcggc tacattcaat cagaccagtc agatacagca aacatgttta caaaagatgt 751621 tctcaaaaaa atgaagtcga taaaggtcac aaaagtcggc agcaaagaca agatgaaaaa 751681 actgattgat gaaaagaaaa tcgatgtagg catcgttatc ccgaaccatt gggaagccgg 751741 caaaacctca gctgttgtta atgccgctcc tgatcaaaca ttgaaaagtt ccatcattga 751801 aacagctgca agctcattta tagagcaata taaagcggta aaggaagccg cgtcaggctc 751861 aatggactac atcagtaaaa cggaagctgt aaagcaagga aaacttgacc ctgcacagtt 751921 tgcagaaaag ctggcaaaga cgctagaaaa agaaacaggt gacaagctta ctattgcgga 751981 aaaatctgtc ggcagcaaag ccgttaccag ttttcaatac tattcggcgg caatgctttg 752041 catgtttatg ctgtttcata tcacagtcgg ggcgaaatca tttttacagg aaaaggatac 752101 ggagacgctt gccagaatgc tgatgacgcc tgcgcaaaaa tccgtcattc tcttcggaaa 752161 atggcttggg acgtatctgt ttgccatcat acaatttttc atatttctga tcgtcacaat 752221 caacgtattt ggtgtggact ggggcggtaa tctgctgtta gtgagtgtac tcgggctttc 752281 ttacgccgca gctgtatctg gtatttcaat gctgcttgcg tcgtgcatca gcgatatgaa 752341 aactgcagat gcgataggcg gcttcggcat tcaattgctt gcggttctcg gcgggtccat 752401 gctgccgctg taccaatttc cggacgtctt gcagtctgta tccaaagcgg tgccaaatcg 752461 ctgggcgctt gacggctttc tttctttaat ggaaggggga ggctgggctg accttcaaaa 752521 gcctgtgctt ctttttgcgg cgatcggctt ttgttcactt gtaattggta tcagacggct 752581 tcatacaaga taaggaggta caaaaggtga aaaaaattct agccatttgc ggcattgagc 752641 tttctctcat ttttaagaag ccacagaact atttgatcat gtttgctgcc ccgcttttgc 752701 ttacctttgt atttgggagt atgctcagcg gcaatgatga taaggtgcgg cttgcaatcg 752761 ttgatcagga cgatacgatt ctctcacagc attatattcg gcagctgaag gcacacgatg 752821 atatgtatgt attcgaaaac atgtctgaaa gcaaagcgtc agaaaagctg aaacaaaaga 752881 aaattgccgg gatcatcgtc atttcccgct cgttccagac acagctggaa aaaggcaaac 752941 atcctgagct gattttccgt cacggccctg agctgtcgga agcgccgatg gtcaaacaat 753001 atgcagaaag cgcattggca acgctcaata ttcaggtgac cgcggcaaaa acggcatctc 753061 agacagcggg agagaactgg aaggcggcgt ataaaacggt tttcgccaaa aaacatgaag 753121 atatagttcc ggctgtaaca cgacagacgc tcagtgataa aaaagagggt gcggaagcaa 753181 gtgacacagc ctccagagca gcagggtttt ccatcctgtt tgtcatgctg accatgatgg 753241 gagcggctgg aaccatttta gaagcaagaa aaaacggcgt atggtccaga ttgcttacag 753301 cctctgtcag ccgagccgaa atcggtgctg ggtatgtgct gtccttcttt gtcattggct 753361 ggattcaatt tggaatattg cttctttcca cccattggct gtttggcatc aactggggga 753421 atccggctgc agttattgta ttagtgtcac tttttctatt gaccgttgtc ggcattggat 753481 tgatgattgc ggccaacgtc agaacgccag aacagcagct tgcgttcggc aacttgtttg 753541 tcatcgcaac atgtatggtg agcgggatgt attggccgat cgacattgaa ccgaaattta 753601 tgcaatccat cgctgaattt cttccgcaaa agtgggcgat gagcgggttg acagagatta 753661 tcgctaacgg tgcccgcgtc acagatattc tcggaatctg cggcattttg cttgcatttg 753721 ctgcgatcac tttcgcagcg gggctgaaag cgctccgagc ctaaaaaaca tctgccgttt 753781 aggcagatgt ttttttgcat gtgggtacat tcgtatgggt gcagcctgaa ctgcggttaa 753841 tccttatcta tcatagctaa aattgattcc agccaagaaa cgtaattttt ctcccgctcc 753901 agcgctttcg ttagcacaag atagtggccg aagtccggtg aagaaaatga catcggctct 753961 gctgaagcca taagcttttc atagcttccc tgtaagtcag aaagcttggc ctggcgtttt 754021 tgcagctggt ctttgaacaa atcagaagcc tcctggcgcg atagacaaga aatgaaataa 754081 gccttcagca taaattcatc cttcaccgtc tcgggtatcg gctggtggcg gatcagccag 754141 tcatgcagct cctgctttcc gctgtctgtc agggtgtaca tctttttctc cagctttgtg 754201 ccctgaatcg ttgtccggaa cgtgataaat ccttcatccg tcagcttttt gagctcaggg 754261 taaatctggc tgtgcttggc gctccaaaac tggccgagct cctctttaaa ataactcgta 754321 atatcgtatc cactcaattc gccttttcgc aaaagcccta atatggcgta ttttaatact 754381 ctcatgctat cctccgtgtc tggctgtttc gcaaaacaga tgagccggtg ctcaactgtg 754441 attctaactg cctattcccc ttattataga aaagggagga agggaacaca accgggctct 754501 ttggaaatga agataaaagg tttgtcagaa ggtatccgat ttatctccgt caatataaaa 754561 gagatttaaa tttaattttc agaaaaaata gtaacgatat tgatttttta tatataatag 754621 gaaattggtg gtatgaaaat tttttggggg aataaacgtg aaaaaagtac ttatggcatt 754681 cattatttgt ttatcgctga ttctatctgt tttagccgct ccgccgtctg gcgcaaaagc 754741 tgagtcagta cataatcctg tcgttcttgt tcatggaata agtggtgcat catacaactt 754801 tttcgctatt aaaaactact taatttctca aggctggcaa agcaacaaac tgtacgcaat 754861 tgatttttat gataaaacag gaaacaacct aaataacggc ccgcagcttg cttcatatgt 754921 tgaccgtgtt ttaaaagaga ctggggcaaa aaaagtagat attgtggctc atagtatggg 754981 aggcgccaat acgctgtact atattaaata tttaggcggg ggcaataaga ttcaaaatgt 755041 cgtaacgctt ggaggggcta atggtttagt gtcatcaacc gcgctgccgg gcacagaccc 755101 taatcaaaag atcctctata catctattta cagtctcaat gatcaaattg tcatcaatag 755161 cttgtctcgg ttacaaggag cgcgaaacat ccagctttat ggcatcggtc atattggctt 755221 gctttctaat agccaagtga acggctatat caaagaaggg ctgaatggcg gaggcctcaa 755281 tacaaattaa tatcttcaaa aaacaacctg ctgtctccgt tacagtgggt tttttcgtct 755341 gagaaagcca tagggtctta tgaccttagt ctatcatgca tacgtcaatt tatgacatca 755401 ggcacttttt caaatagagc ggacatgtta aggtacaacc atcgatttct atcaatttga 755461 aataaaagga gcgctgttat gcaaattaaa gaaattttta tgatccgctg catttcgtgc 755521 ttaagtgtcg tcttgctcca tatcatttca atggtcctga tgcttcaggc agaagctctt 755581 gcagatattt ctcacactgt tgattctttc cgcacactcc tgatgttcag cacgcccgct 755641 tttattttca tctctgaatt tttactggcc cgttcttatc ctgatggggt gcctgacggt 755701 tttttaaaga agcggggaaa agtgattttt gttccttttt tatttatcgc agccatcgat 755761 gcgctgctga tgaccagtgc gatgggggga gaggtaacct ttctcgcgtt tgtgcaaaaa 755821 tatctggcga acgtattctt aggaaacttt atcggatact tcattctcgt catctttcaa 755881 ttttacatgc tgcatatgat gtttcatgag tatttgaaaa aagcatcgcc gaaatgggtg 755941 ctgtctatct catttgtggt gacagccgct tatttaggct atttctccgc agccagcccg 756001 gctcctgctt ctgaagaggg aggggcattt ccgttcttct gggttccgtt cgcaggctgg 756061 cttttctact tttgtctagc ctactattgc ggaaaagaat acaagcgttt tttagcgctg 756121 ctgaaccaat accgctgggt ggtgtacggc gccgcaattg cttctggggc gctggttgtc 756181 actgtttctt atgtcggtga aatcggcatg atcagctcga agcggcctga tatcatgctg 756241 tattcaacaa gcatgatttt cctgtgtttt catttgtttt ccaaaatgaa gcatgtgccg 756301 aaaatcatga tgtttatcag caactattcc ttttcgattt atctgcttca tgcctatttt 756361 atgattatag gctacgtgtt gcttttgaat atgcccgaaa ttcctgccgt accggctgtt 756421 ctcctgttgt ttgccgtgtg cacagccggc ccgattatga cctcatgggc gctgaataag 756481 ttcaaatacg ggtatttatt tgtggggaaa atttatcagc caaaacagaa gaaggtaaca 756541 gtcgaagtgc gtgatcacgc agggtgaaaa acaagcggca ggagggctcc tgccgcgttt 756601 ctttacttct catccgcttg cagaactgtt tttaaatata gttttgcaga ctcagcaagt 756661 ccagatacat cagccttttc ttcatcgaaa tacagggcgt tttgaatgat gccgtcattc 756721 atattgagga aaaacttggc gatagtcgca agaggctgaa ccggctgaaa ctctccctga 756781 tcgatccctt tttgcaatag ccttgaaaac ctttccacaa aaagatcata ccttttctcc 756841 aaatactgcc gccgttcttc attgcgccaa gctgtcacta aatattcaaa ttgcaccggc 756901 gccagcgtat ctgctacatc tcgcaggccc tcagtcagtt catccaaata gctggaaatg 756961 gaggcccaaa cactttggtg ttcagctgat ttatcaagct ttcggagtcc ttcatccagc 757021 cctgtttcaa taatgcggcg aaacatctcc tcagtgcttg aaaaataaag atagacaccg 757081 ccccggctga aacctgactc ttctacaaca tccttcatcg tcgttaattc gaatcctttt 757141 cgtttaaaaa ccgttttggc agcctctaaa atctctgcct gccgtttatc cttgtgctcc 757201 tttgttactt ttggtgacaa gatatcgcct gctttctgca attttcttac ctataagtgt 757261 aatcaaccca atcatgatca gcaagcagcc acagacaaga aaagcaagtg atacaccgat 757321 ccattccgcc agcacgcccc cgcccgccat gccgaggata gaggcgaggg ttgtcgcact 757381 ctgaatagcg ccgaacaccc taccgctgta atcgacaggc actgttgttt gcacgagaat 757441 ctgaaatgga atatggacga ggccgaaagc cgcccccatg atgaaaaaag caaatataaa 757501 gagagtgatg ccggcaattc ccataccgct taggaatggc gcacctccag ttgctagtcc 757561 aagaagaagg gttccagctg agaaataaag caaataagaa gtgattcgcc gtctgccggt 757621 aatggccgct gtaaggagca tcccggctcc gcttacggcc atgcaccagc ctgccagctc 757681 gggcggagct cctgaaaagg agcggataag aataatcgct tgggaatcac caatctgcaa 757741 aacaaagaga acgacacaag ctgttagtaa gcctgttaat agaagcggca tccgtttcaa 757801 aaactgaagg ccttccttga tagaagtaag tgctgctgtt ttttcttgag gtgtattggc 757861 tttttgtaaa aaagcatctc tgggaaggaa aaacaaaatg acagcggaaa gaaagaaggc 757921 gccggcgttt atataaaaaa cagagtgtat cgagaaagca gcgatcagcg tgccgccaag 757981 ggcagggccg aagatttttg agctgttatc aatgatgctg ctgacggaaa cggcctgctg 758041 aatgtgtgct tccggagcca attccttaag ctttccgttt ttagcaggta aaaaaagtga 758101 agaaaaacag ctctgaacgg atagcaatac gtaaagctgc caaagctcac tgacataaac 758161 gcagctgata acagtgaggg cacggccgat ttcagataga aacatgatcg tttttctgtc 758221 aaaacggtcg gcaagcagac ccgatacagg tccgagtaca atgacaggca aagcaaacga 758281 catcattaaa agcgacatat ctaatggaga agcatgaagc tgaaaagcgg ctaatgttag 758341 cacggccaaa atgtgaagcc agtctccaag tgaagaaatg gtttgcgagg ctaacagtgt 758401 catcagtcct ttttgattgc gaaacaacgg tttttccatg attcatcctc ctgattatta 758461 aaatgacact agtgtcgttt ttaattgtat gggaaaaaga cacaatatac aatctttttc 758521 ttgtaaaata aaggagaaga ttgaatagaa gggagaacat tcatgacatc agtcaatcta 758581 agctacccaa taggagaata caagccgagg gaatccatat cgaaggagca aaaagataaa 758641 tggattcaag tacttgaaga agtgccggca aaattgaagc aagctgtaga ggtcatgacg 758701 gacagccagc ttgacacacc gtaccgggac ggtggatgga ccgttcggca agttgttcat 758761 catctggctg acagtcatat gaacagctat attcgtttta aattgagctt gacggaagag 758821 acaccggcta tccgtccgta tgatgaaaaa gcatggtcgg agctaaaaga ctcgaaaacg 758881 gcagatccga gcggctcact cgcgcttttg caggagcttc acggaagatg gacggctctg 758941 ctccgcaccc tgacggatca gcaatttaag cgcggatttt atcaccctga tacaaaggag 759001 atcattaccc tggagaacgc gctcggcctg tatgtctggc actcacatca ccatatcgct 759061 catattacgg agctttccag acggatgggg tggtcttaac gcttttgccg gcggaaagcc 759121 ggaatactga tagcagcaat caccagaagt gagaccacag cagccgctgc atataaatga 759181 tcatagccgc tggcgacact cgcatgaatg gcgtcgctta tcgcggtttt gacttcagga 759241 acgggaatgc gttcgatttg ttcttgtaaa gaagaaactt cagaactgtc gatctccgga 759301 atcatctgca tcgccttttc tgaatatccg ctgtccgata agcggctgtt gatctcatca 759361 cctatttggt caaacccggc tgtgataaaa cctgcataaa gagtaggcgc caaggtcagt 759421 ccaatttgcc ttactaatga aagcgtgcca agagctgtac ccttatttgt ttttgccgct 759481 tctgatacaa ggacgttcag cggagcgcct aacagaaagc caaaaccgat cccagctgcc 759541 acacttgcga tcacaaactc ccatttttcc gtgacccaga gcggaaataa agcaaacccc 759601 gcacatgaga tgattcccga aagaataacg gtttttacag gacctttttt gtcggtaagt 759661 gctccgccaa gccaagcgcc gattccggaa gccaacgcaa gcggtgtcat ccaatagcct 759721 gcttttgcgg cagggacacc caaatactgt tcgacatatg acgggataaa aatgactgcc 759781 gccaagagcc ccccggataa caaaccgatg ataagcgtgc gctgaaacat atggtttcgc 759841 agcagagaat acgccaaaat gggatcgcct cctcgcattt caactctctt ttcatacgag 759901 ataagcgctg caaaacagag tatgccaaaa ataatacatc cataaacctc cggattcccc 759961 aagctgtgta agagatttgc cccgtcaaga ttggtcatgc cgtacatcac agctaaaatc 760021 gacagggaca aaaggaagat tccggccgca tcgaggcgct tagcctcagg tgcttttgtt 760081 tccgcgataa aacatgcgcc gaaaacaacc aatagcacgg caatcggcaa attaatcaaa 760141 aatagccaat gccaagaccc ggtccaatca agcagaaagc ttccgatatt tggcccgagc 760201 acagcggcca tcccgttcat tgcgccaagc agcccaagcg ccttcccctg tttttccttt 760261 ggaagggtcg cgagaatgtg agagctgccg atgatgaaaa tcccgccgcc tccaagcgcc 760321 tgaatcagcc gcgatatcag aaagagcggg aagctttggc tcaaagcaac aagcaaagaa 760381 ccaagtccga acaggcaaac ctcaatgaga aagagttttt ttctgccgta gcggtcggaa 760441 agttttccga cgattggcac actgacgcta agaccgagcg tataaagggt aatgccccat 760501 gatccccagg aaggggaaac ggaaaacgac tcgtttatcg ttgttaaagc agccgaaata 760561 attccgttat ctaaagcagc cataaacacg ccaatcgtaa acaggctgat tgcccacttt 760621 tggcttttct gctctgttaa tgcttcagac attttcgtca actcctttta gttcacttga 760681 aatatattat tcattttaaa tgaactaaat gtcaaataaa aaaagcctgc tcccgcagtt 760741 tgcggatgac agacttactg atttattctt ttttcgcatt ctctaatgct cttgaaagga 760801 tagacagccc ttcgtaaaca gcctgctttt cttcagggga cagcagctct aatgaacgct 760861 tcaatttcag gtggcccttt tcatacaaac cccggaaaat ctttttcgca ttctctgtca 760921 actgaacaac tacagagcgg cggtcctctt cagaatgtga gcgtttgaca aatcctgatt 760981 tttcaagccg gtcaagcagc ccagttgtat tggacaggga agcccccatt ttttcagcaa 761041 tgtcgctcac tttcaatgtt ccatggttgt ttaatagcat cagcaccttc atttgcggca 761101 tgctcatatc cagtttcatc cactcggaca catcaccgag cccggcggac gttaagactt 761161 tcatatagag cacccatatt tcccgttcct ccgatgaaag aatgttttcg tttaagactg 761221 ttgtatcgtg taaattatat tccatttcat cacttcctca tcattcactc ctcttaccat 761281 attactcgat tttcactcct gaaagaaagt gagcagaaac cgcatgcggg actttgtccg 761341 aaaaataacg gtagtgtata atgagttgga gattattggg ggagaggatc gaactagaat 761401 atgattggag agaccattgc tgattaaaaa gaatgcttta tcaatattaa aaatcgtttt 761461 tcctattgct gttttgctat ttgttattta tcaatcgaaa aaagaactga caaatctgtc 761521 attcaaacgt acgctcatgg tcatcaacgg actggaacga acggatttat tcatgcttgt 761581 gttgatcggc ttgctggctg ttgcggctat gtcgctgtat gattacgtcc tgaagtactc 761641 actgcgccta tcgatcacaa acggaaaagt tttcagggtt tcctggatcg ccaattcatt 761701 taataatgtg ttgggattcg gcggtttagc cggagtcggg ttaagaatga tgttctataa 761761 ggagcatacg aaagaccata aggcactcgt gaaaggaatc gcctggctca catcatctat 761821 gctgctcgga ttatctgttt tcagcatttt cgttgctgcg agagtgctgc cagttgatga 761881 agtgattcat gagaagcctt ggctgtgggc ggtcgttatc ggttttgcac tgatattgcc 761941 gttatcttta gcggtgtcca aaataaaaga ccgcaaagct ggggacgaag agaatgcgga 762001 taaagtgaaa aatccgattt tcgcatatat tggagcttca gttgttgaat ggctcatggc 762061 cgggaccgtc atctattttg ctttgttcgc tatgggcatt catgcagata tcaggtatgt 762121 gttcggggtg ttcgtcattg cggcgatcgg aggaatgatc agcctcgtgc cgggcggctt 762181 cggctcgttt gaccttttat ttttgctggg gatggagcag cttggctatc atcaagaggc 762241 catcgttact tctattgtgt tgtacaggct cgcctactca tttatcccat ttatcttggg 762301 actgttcttt gccgccggcg acctgacgga aaatacaatg aagcggctcg aaacgaaccc 762361 gcgcatcgca ccggcaattg agacgacaaa cgttctgctt gttgttcagc gtgcggtatt 762421 agtgagaatt ttgcaaggct cgctttccct tattgtgttc gtagcaggtc tgattgtctt 762481 ggcctcagtt tccttgccga ttgacaggct gacggttata ccgcacattc cgcgcccggc 762541 gcttttgctg ttcaacggcc tgtccttaag ctcagcgctc attctgctca ttttgccgat 762601 cgagctttat aaacggacaa aacgttccta cacgatggcc attacagcgc ttgtcggcgg 762661 ctttgtgttc agctttttaa aagggcttaa catcagcgcg atattcgtac tgccgatgat 762721 tatcgtattg cttgtgctat tgaaaaaaca atttgtccgc gaacaggcat cctatacact 762781 gggacaattg atattcgctg tggcgctgtt tactgtggcg ctctttaact acaatctgat 762841 cgcgggcttt atttgggacc ggatgaagaa ggtgctgcgt cacgaatatt tcgtccacag 762901 cacctcgcat attacacatg caaccatcat ggcgatcatc attgtgccgc tgttcttctt 762961 gatatttaca gtggtctatc ataagagaac gaaaccgatc ggagagaaag ctgaccctga 763021 gcgtcttgct gcgtttctca atgaaaaagg cggcaacgcg ctgagccatc ttggttttct 763081 tggagataag cggttttatt tttctagcga tggaaatgca ctgcttctgt ttgggaaaat 763141 cgccagaagg ctggtcgtgc tcggcgatcc atctggccaa agagaatcat tcccgctcgt 763201 gctggaagaa tttctgaacg aagcgcatca gaagggattc agtgttttgt tctatcaaat 763261 tgaacgagag gacatggcgc tgtatcacga ttttggctac aacttcttta aattgggtga 763321 ggaagcatat gtagatttaa atacatttac cttgactggg aagaaaaaag ccggccttcg 763381 ggcaatcaat aaccgctttg agcgggagga gtatactttc catgtggatc atcccccatt 763441 ttctgatgcg tttttggagg agctgaagca aatctcagac gaatggctcg gctcgaaaaa 763501 agagaaggga ttctcgctcg gattttttga tccttcctat ttacagaaag cgccgatcgc 763561 ctatatgaaa aatgcagaag gagagatcgt tgcattcgca aatgtcatgc cgatgtacca 763621 ggaaggagag atatcggtcg atctgatgcg ctatcgcggc gacgctccaa atggcattat 763681 ggacgcattg tttatccgta tgtttttatg ggcaaaggaa gagggctgta cgtcatttaa 763741 tatggggatg gcacccttgg ccaatgtcgg cactgccttt acatccttct ggtccgaaag 763801 gtttgccgct gtcattttta ataatgtcag atacatgtac agtttcagcg gcctaagagc 763861 ctttaaagaa aaatataaac cggagtggcg agggaaatac ttagcgtatc ggaaaaacag 763921 atctctttct gtcaccatgt tcctcgttac acgtctgatt ggcaaaagca aaaaagactc 763981 cgtctaataa gacggagtct ttttttattt cgtttttaag aagtaggttt caatatcatc 764041 aagcaggtag tttgcggctt taattccgcc tgcggttgtc catacgacgt catcgacttc 764101 atgtgcatta cctgacttca cggccttcag gtttttccat agtgaactgc ttgtccactg 764161 attggcccat ttttcatttt cttttgcatt atcggcttta taagtgaaat aaaacagcac 764221 atcagcatcc atatcaggaa tagattcttt actgtcggtt gagaacgtaa attggtcctt 764281 ttgtttctta aacagttcca cttgtttttc agggcgtttg aagccaagct ggtctaaaat 764341 aatcccagga aatgaatcgg tataatagat tcttgattca ccggataaaa agcgtacgac 764401 tgaaacggtt ttgtttgtct ggtcgcccag cttgtttttt aaatcagaaa cacgtttatc 764461 aaaatcggca atgacttcct tgcctttgtc cgccttattc accgcgttgg cgtatagagt 764521 caggttatcc ttccagttcc cggccaaaga ttcagcaaaa acagtcggcg caatcgcatt 764581 taactgatca taaatttttt cctggcgcac tttgtttcca ataatcaaat caggctttaa 764641 ttctgcgatg gcttccacat tcggttccgt ttcaagaccg acgtttttaa cacctttcat 764701 gtcatctttc agatagtcat accacgggtc gcccttccat gactttacgg ctccgaccgg 764761 cttaatgcca agcgctaaga gcgcctctgt tccttcatta gttaaaacaa caatccgttt 764821 tggattggcg gggatgttgt ctgatgtccc cattgcatgt ttgaccgttc ttgttttgct 764881 gcttgacacc tcgctgttgc ttgaactttc tgaactatta caggcagaaa gtaccataac 764941 ggccattaaa aatacgaata gcatgctgat atgctttttc atctttttcc tcccaatatt 765001 gaaattcatt atcatttaga tcataataag cagtgttaag agtgtcaatc cctaattgag 765061 gattattctc aaaaacaaac attacatagt aaataactag gagaattaga tcatgatctg 765121 caaaaaggca tcttcaaaat ggattgtgtt agtatgtctg attttcattt tactgacggc 765181 tgtctgcgca agcgtcgtgt atggctatac aggtacgtca tggagacagg tctatcaggc 765241 gtttacttcc ttcaatggaa caaatgagca tgtcatcatc aaggatgtca ggcttccgcg 765301 cgctttggtt gcgacagtcg tcggcgcctc gcttgcagcc gcgggcgctc tcatgcaggc 765361 gctcacaaaa aatccgcttg cgtcaccggg gattttcggg attaacgccg gtgcaggttt 765421 ttttattgtt gccggatcgt tttttctgca tattcagtca cctcaggcat tagtatggag 765481 ctcgtttctg ggggcagcat ttaccgctgc gatcgtctat gcagcaggct cgcttgggag 765541 ggaagggctg acgccaatca aactgacgct ggcgggagct gccatggcag ccatgttttc 765601 ttctctgaca cagggcttgc tgtctgtcaa cgaactcgag cttgcccagg tgcttttttg 765661 gctgactggc tctgtgcagg gccggagtct ggatctgttg atgacgatgt ttccatatgc 765721 agcggcagcg ctggtaatct gcttctttct cggccaaaaa attaatctcc tcgttatggg 765781 agaagatgtg gcaaaaggac tcggccaaaa aacaggcctg ctgaaatttg tgatggcgct 765841 ttgtgttgtc atgcttgcag ggtccgctgt cgccattgcc gggccgattt cttttatcgg 765901 catcattatt ccgcattttg cccgctttgt cgttggtaat gattatcgct gggttctgcc 765961 attttccgct gttttgggtg ccattttgct tgtttgcgcg gatatcggtg cgcgatatat 766021 cattatgcct caggaagttc ctgtcggggt catgaccgcc atcatcggaa tgcctgtgtt 766081 tgtgtacatc gcaagaaggg gggcgaagct atgaaacttc gttttggcgt tactgcggct 766141 gaaaagaaag catggatcgt ctttttggtt ttactggggt taacagctgc tgtactcatc 766201 ataagcgctg gtctcggaca aaggtttatt cctccctggg atgtagcaaa aacattcttt 766261 ggtgcaggtt ccaagctgga tgaactgatg atcatgtcgt tccgcatgcc aagaattttg 766321 acggctttat gcgccggtgt ctgcttggca gcggcaggcg cgatattgca ggggctcgtc 766381 agaaaccctc tcgcatctcc ggatattatc ggaataacag gaggagcggc ggtagcggtc 766441 gtgcttttaa tgatgttctt ctcagaccgc agcagttcac ttacgatcag tctgtcatgg 766501 cttccagcag ccgcatttat cggcgcatcg gctgtcgggc tcatcgtcta tttactggca 766561 tacaaaaatg gcgcctccac atttcggctg gtgcttatcg gaatcggatt ttcaatgtcg 766621 gcgcaggcga tgactaccct gttgatgatc aaaggcccga tttaccgagc atcacaagcc 766681 aatgtgtata tcactgggtc agtttatggg tcaaactggc agcatgtaaa aatagctatt 766741 atcttatctg tcattctctt attcatttgt tttgtcgcgc taaaaaatat gaatatacag 766801 gtgctgggtg aagatattgc ggcgggtgca ggaagcgctg tgcagcgaaa tcgttttttc 766861 ttgctccttt tgagtacggc tcttactggt tgtgcagttt cagttgccgg cacaatcggt 766921 tttgtcgggc tgatggcgcc ccatattgca agacggcttg tcggctcatc ttatggcgcg 766981 ctgctcccag cgtcggcact tattggagct ctgctcgttt taacagctga tatcgtcggc 767041 agaaccttat ttgctccggt ggaagtgccg gccggcgtct ttacagcggc tatcggcgca 767101 ccttatttta tttatttgct ctataaaaca agaaattctt aatcgttaca cccattttct 767161 taaaaaagaa aatgggtttt tttgataatg actgaagatt cgtaattatt tttgctatac 767221 tgacagagac attgataaag aaagggcggc agatgaatga aagaagcaga ggtattaaaa 767281 tatgaagcat ttacaagcag tcccggcaaa ggaaaccccg caggcgtcgt tttgcaggga 767341 gacgattata cggaagacga gatgcagatc atagctgaac gtgccgggta ttcagaaacc 767401 tcctttatcc gaaaaagcga gtcggccgat cttgaactcc gttactttac ccctggacac 767461 gaaatgaatt tgtgcggtca tgcgacagtt gcttctcttt acgcattatg tgagaaagga 767521 atgctggaga gcggtaaaac gtacagcatc caaacgaaag cgggtatcct gcctgtgaag 767581 atttctgaaa aagatggccg cattcatatc acgcttgaac aggcctctcc gcaattcaaa 767641 ccatttacag gcgatcggaa aaaacttgcg gacgcactgg gtatcaccga tgaagatttt 767701 catgaagacc ttccgattgt gtttggcagc actgggatat ggacagccat cgttccgctt 767761 aaatcattgg aggcttccaa aaaaatggtg ccagataaca aacaatttcc ggaagtgtta 767821 gttgatctgc caaaagcttc agtccatccg tttacctttg aaaccgtcca tcccgacagc 767881 gacctgcacg ggcgccactt ttcatccccg tattcgggaa cgattgaaga ccccgtgacc 767941 ggcacagcat ccggcgtgat gggggcttat atgaaacatt atggcaatgc cgagcagcat 768001 aaatttatca ttgaacaagg gcaggaaatt ggaaaagacg gaaaagtgga gatcgaaatg 768061 aacgaagccg gcggccatgt gaaagtgaac atgacaggaa cagccgttta ctcagaaacc 768121 cgtattctta aaatctaata cggatgatgg tttacaaaaa gatgcacttt ccgttatcat 768181 tatgaaatga taatcatttt caattgcata ggaaggtgag acggtatgcc tcaaaccgaa 768241 caaatacatc agcattcagt actgagggac atcatacgca gcagaagatc gattcgaaag 768301 tttaaacaag agccagtacc ttcagcagtc attcttgaca tgcttgaaac ggcaaaatat 768361 gcgccaaatc acagagtgac agagccatgg agatttattt acgtttccag tgagacaggt 768421 aaagcgaacc tcattaatac atttgcagcg ttctctaaga aatccaagcc ggatatgaca 768481 gaggaaaagc ttcaaaattt caaaaacaca cttgggcgcg ttccgggatt tctcctcgtc 768541 gtgtttcagg aagatgaaaa cgaaagagcg cgggacgacg attttgcggc aacaagctcg 768601 ttgattcaaa atcttcagct tctcgcttgg gaaaaaggaa tcggcatggt ttggaaaagc 768661 ggaaaaatcc tttatgacaa agaagtccat caggcctttg gtttacagga taatgagcgt 768721 ttcgccgcca tcatacaaac aggttatcct gacgaggcgc cggaagtgaa aaaacgcaca 768781 ccgatccgcg accgattcac tgaaatgtaa aaaacccctt gtctcaaacg gagacaaggg 768841 gtttttcatt aacgagattt ctttttcgct ctgttgtcgg ctgctttcgc acgctcttgc 768901 gcttcgcggt catctgcatc agcaagctcg gttgaatatt cttcgtaaac gccgtcagtt 768961 tcccttttta aggcatcggg aacttgtgga agcttttgtt tgtttttatc acggtttttg 769021 tggatatgat ttctgcccat atcaaattcc ccctaaaaag tgatatcaaa caaatatagt 769081 atttggtttt aaggggctat gtattcctac ttccgcttag cagctttttc cgctttttta 769141 aattcgcctg aataaagaac ttcctgcatt tttttcaggt tggcgccttg ctggtgcttc 769201 tccctctttt tttccataaa aaggacctcc ttcaaccatg ttattcttaa ggttgacgct 769261 tcctgctgtt tttatacagt ctttcggtcc gctatcagct gtgagagtgc aaattcaaga 769321 tccgaatatg taaaacgaaa tccagaggtt atcgcttttt tcggaagagc gcgctgtcct 769381 ttcacaatca aaagactcat ttcacccaat gcttttgata aaaagaattc cgggacgggg 769441 agccagtgcg ggcggtgctt cacccgtgca atcgtttttc cgaattgctt catgtccaca 769501 ggattgggcg cggtgacatt cattgggcct gagatgccgg cgttttccac cgcatatcgg 769561 atcatctggg ccgcatcctc gacatgaatc catgacagcc actgccttcc cgttccgatc 769621 gttccgccgg ccagaaactt ataggggaga atcatgagcg ggagagcgcc tttttctcca 769681 agcatcacgc caaatctcgc ataaactgtc cggatgccca tcgcttcaat atgctgtcct 769741 tccttttccc acaggtgtgc agtatggctg agaaaatcct catctgacgt tgcagaatcc 769801 tctgtgaaag ttttctcaag gcttgtgccg taaatgccca cggcactggc ttggatcaat 769861 gtcttcggct tctccttctg tttctgaata agccgctgca cttcacgcgt cgcattgata 769921 cggctggaga gaatgtgctg cttcgttttt tctgtccagc ggccaaaaat cgattttccc 769981 gcaagattta tccagacatc aatatgagga agttcctgct ccggtgcggc tccttccgac 770041 agccattgga catatgtcat atttttttgt tcagtttccc ttgcgtttct tgataaaata 770101 taaacatggt gtccctggcg ggtaagaacg cctgtcagat gctggccgag aaaaccggtt 770161 ccgcccgtca ttgcgatatt catgaacatc tctcctcatc gttctaataa atatacttta 770221 cctcattgta ataaaagaaa acgcgtttca ggcctgagaa gggagattaa gatgccgttt 770281 attacaaaaa tatcaacgca aaaaaagaat acggaacgct tcaatatttt tctggatgat 770341 aaatacgcct tcagcgtgga cgcggatgtg ctcgtgaaat ttgagctcaa gaagggaaaa 770401 gaactcgatg atcttgacat cattgagatt caatacggcg atgaagtgaa gaaaggcttc 770461 aaccgtgcgc ttgacttttt atcctatcga atgcggtcga cgaaagaggt cgaggatcac 770521 ttaaagaaaa aagaaacctc gccccccgtc attgcggaag tcatccatag gcttaacgat 770581 tacaagtact taaacgacca ggaatttgcc gcagcctatg tcagcactca caaaaaaaca 770641 aacggaaaag gccctgatgt tttgttcaga gagctaagag cgaagggaat tgatgacgat 770701 acaattaagg aggcgctaag ttccttttcc tttgaagatc agacaagaga agcggtcaag 770761 catgttgaaa agcttctcaa aaaagataaa aagctttcga cgaaagaact caaacagcgc 770821 gcccagctgc agcttcagcg caagggcttc tcatttgatg ttatcagcgc ggcgatggat 770881 cagattgaat atgaaaatga tgaagacaca gagaaagaag cgctgcgcct tcacgcggaa 770941 aaagcgttta gaaaataccg ctatgacggc tcatatgaaa gcgccatgaa ggtcaaacaa 771001 tttttattcc gcaaaggatt ctcactcgat ttaatcgagc aattactgca ggaagaggag 771061 tactgaaatg gagaaacgat acagtcaaat gacaccgcat gaactcaata ccgaaatcgc 771121 attactttct gaaaaagcaa gaaaagccga acagcatgga atcataaacg aactggcagt 771181 gctcgaacgg aaaattacga tggcaaaagc atatttgctg aacccggaag attactcacc 771241 gggagaaaca tatcgtgtgg aaaacactga ggacgagttt accatcagtt atttaaatgg 771301 cgttttcgca tggggataca ggacctcttc ccctcagcaa gaggaagcgc tgccaatctc 771361 agtattgcaa gaaaaagaat aaagcgtaac aggaggctga tgatcagcct ctttttgttt 771421 gcagcacatt tacacgaatt cttaaagaaa aaatcattga attcacttga aaaatctttt 771481 aagatgaaac tcgttgtttt ttaaaatcaa aggaggcgat gacgttgagt atcaaaaacc 771541 catctgtaaa atttattata tttgttctta tgatttgtac attttcaatc ggctatacag 771601 aatacgcggt gatgggtatt ttgacgtcga ttgccaatga ctttcatata caggtttcat 771661 ccgcagggct tcttgtcacg gcttatgcgg caagcgtttg tttgacaggg ccgctcgtca 771721 ccatcatttc cgtcaagctt ccgagaaagc ctgtgcttct tgggctgatg gcgatattta 771781 tcctttccaa cctgatgagc gcactggcgc cgaattttgc ggtattggcc atttcaagaa 771841 ttttatctgc gtccattcac ggcgctttct tcgcgattgc catggtattc gcaagtgaaa 771901 tggttccgcc ggaaaagcgt gctgcagctg ctgcttcaat gaacggcgga ctgacagtgg 771961 ctctaatgct tggtgttcca ttcggctctt atctcggaga tgtcctgaat tggagagcgg 772021 tgttttccat cattacggca cttggtgtca tcggattttt aggccttatg gctgccgtgc 772081 cgaacagaaa accaaaagtg atcccaatgc ttatgaatga gtggggtgtt tttaaacaca 772141 aacaagtgct gttttccttc gcgattacca ttttaggcta ttccggtgtc tttatcgcct 772201 acacctttat cgaacccatt ttgaggcatt cagccggatt cagcacggtt ggcattacag 772261 gtgctctctt tgcgtatgga ttgggaggcg ttgccgggaa tttctttgct ggaaaggtac 772321 cgctgccttt gctgactcgg acgatgatcg gcgtaatgat cggtttaatc ggtgttctgg 772381 ctgtatttcc ttacatcgcc atttacccgg ctgcagccat tgtggcaacg ttcctattcg 772441 gggcatgcgc attcggcacg ccgcctcttc tgcaaacaaa ggtcatttcc tcatctgagg 772501 gcggcacaac cattgccgca gctgtcagcg tatcagcatt taaccttgcc aatgcccttg 772561 gtgcatggat cggcggaatg attttaaacg gaacaggctc ttattcctgg ctgtttgcag 772621 gaggtgcgct tatgaccgca tgcggacttg tgctttctac cttcgcacac ttatcagaaa 772681 agaagagcgt ctacgaatat caagtcaata aagggtaaaa aacagctgca gtgtatgcag 772741 ctgttcttct ttaccgtttg cctgaggctc tcattctttc ttgaggatgc tgattgatag 772801 atccgtcagc acgctttgaa gcatagtcgt cctttgctct cggttcaccc tgaaatttgt 772861 tttcgttttc gtaaggaaat cctttttctt tatttcggac catgtcatat ccccctaggt 772921 tcgagatcaa aaagttgcgt cttttcagat gaagacgtaa ggttagtata tggagaacac 772981 cacgtaataa agcgttattt ttttcctgaa gaaaggagac tgcacacatg aatatgtaca 773041 ttgagaaact gactaatctg cttctggaaa agaacgagat gatcagctat atacaggcaa 773101 aaacgtgggt ggaattgtta tggagcgatt tcgaagcaac ctacgcaaaa gccggacacg 773161 cctatcaagg tgaaaaaatg actgaaaaaa tcgtcacaca atggattgaa aactatggcg 773221 gccagctcca cctttttcaa agctcccgta acgacgtgaa tgattactta aatcaaagca 773281 gaggcctttt gcattaaaaa cctgccgtta acgaccggca ggttttttca ttttcttaaa 773341 attaccttaa caggaagaaa tcataaacaa aacatgtttc accagcctgt caatcaggga 773401 ataccactta tatcttgtca aaatgcgagg aggagcttta tatgaaaaag aaacaagtaa 773461 tgctcgcttt aacagctgcc gcaggactgg gtttgacagc acttcattcc gctcccgcag 773521 caaaagctgc gccccttcac gacatatctg tcagcatgcc atcatccgat acttacatca 773581 taaaagcagg aaagctgaat gtccggactg agccaaatca tgaaggtgat attctcggca 773641 ctgtatcatc agaacaaaag gtaaaagtcg ataggttcgt aaatgccgat tgggctcaaa 773701 ttcatttcaa aggaaagaaa gcatatattt caactcactt tttaatgaaa accgcaagcc 773761 aagcgaaaac aacgaaacag acagccttct atacaccgac gcccgaaaac ggaaaagcta 773821 agcagctctc atctggaaca gaggtgacaa tacttgggtg gggattcagt gaaaacggcg 773881 gatttgactt cacttgggcg ttcgtggatt atggcggagt taaaggctat attcacacaa 773941 aggatttaca aatgcgataa aaaggcaggc cgaggcttgt ctttttgcct atgcatgaaa 774001 catttcttct ttctgcacgt aacaatgaga aaggagatga tgatatgacg ggtttagtcg 774061 gcggagggct tatgatcatt gcgggcatac tgatcaaact gtttcctccc aaatcgatca 774121 acagtgtgta cggatacaga acgagacgct caatgtcaga tcaaagatta tggaatgaag 774181 cgaaccgtta cagtgcatca ttaatgatcc tgtcaggctt ggtgattgcg ggaatgggtt 774241 tgctgctggg atcaaacttg tttattcttc agcttatcct gctgattgcc gcctgtgtca 774301 taacatttat gctaacggag aaaaggctga aaatcatgac gcacagtcaa ggaggagata 774361 gaagtggacg gagttaaatg ccagtttgtc aatacgaacg gaatcacgct tcacgttgca 774421 gccgcaggac gggaagatgg cccgttaatt gtcctgctcc atggatttcc tgagttttgg 774481 tacggctgga aaaatcaaat caaaccgctt gttgatgcgg gttaccgggt cattgctcct 774541 gatcagcggg gctacaatct cagtgacaaa ccggaaggaa ttgattcgta tcggattgat 774601 acattaagag atgatatcat cgggcttatt acgcaattca ctgatgaaaa agcaattgtc 774661 atcggtcatg actggggagg agctgtcgca tggcatttgg cttccacacg cccggaatat 774721 cttgaaaaac tgatcgcgat caatatcccg cacccgcacg tcatgaaaac cgtaacgccg 774781 ctttatccgc cgcaatggct gaaaagctcg tatatcgcat acttccagct gcccgatata 774841 ccggaggcat cactaaggga aaatgattat gatacattag acaaagcgat tggattatcc 774901 gaccgtcccg cgctttttac atccgaggat gtcagcaggt acaaagaagc gtggaagcag 774961 ccgggcgcgc tgacagctat gctgaactgg tacagagccc tcagaaaagg aagcttggca 775021 gagaaaccct cttacgaaac agtaccttac cgaatgatct ggggaatgga agaccgcttt 775081 ttgagcagaa agcttgcgaa agagacggaa aggcattgcc cgaatggaca tctcatcttt 775141 gttgatgaag cttcccattg gattaaccac gaaaagccag ccatcgtcaa tcagctgatt 775201 ttggaatatc ttaagaacca ataagctaaa atttctctcc atccgtctgt cataatggca 775261 gactttttct gtgcgttttt tttcatagtc tgttttaaac atgacaaaat aacattaaaa 775321 atcatgaatg tcaccataaa attgtaacaa aaaacaggtt taaacgactt taaaaaaagg 775381 aatagcctta ctgaagattt gtgtaaaact cccctaaggc aatacttaaa aagaataata 775441 aaaagaaggt gccttaatga agcaaggatt aatctcgatt attatcccgt cttacaatga 775501 agggtataat gttaaactca ttcatgaatc tttaaaaaag gaatttaaaa acattcatta 775561 tgactatgaa atattcttca taaacgacgg aagtgttgat gacacgcttc agcagatcaa 775621 agacttggca gcgacgtgca gccgggtaaa atatatatct ttttctcgaa actttggaaa 775681 agaagccgca attttggcgg gctttgagca tgttcagggc gaggcggtta ttgtcatgga 775741 tgccgatctg cagcatccga catatttgct gaaggaattt atcaaaggct acgaagaagg 775801 gtatgaccaa gtcattgccc aaaggaacag aaaaggggac agctttgtcc gctcactctt 775861 atcatctatg tattacaagt tcattaataa agcggtggaa gtcgatttgc gtgacggtgt 775921 cggtgacttc agattgttaa gccgccaagc tgtgaatgca cttttgaagc tgagcgaagg 775981 aaaccgcttc tcaaaaggcc ttttttgctg gattggcttt gatcagaaaa ttgtatttta 776041 tgaaaatgtc gaacgaaaaa acggcacctc caaatggtcg ttcagcagtc tgtttaacta 776101 cggaatggac ggcgtcgttt catttaatca taagccgctg agattatgtt tttatacagg 776161 cattttcatc ctgctgcttt ccatcattta tatcattgcc acattcgtta aaattctgac 776221 taacggtatt tctgtgcctg ggtatttcac cattatctca gcagtgttat ttctcggcgg 776281 agtacagctg ttaagtcttg gaataatagg tgaatatatc ggccgaatct attatgaaac 776341 aaaaaaacgc ccgcattatt tgatcaaaga ggcgaatatc ccgaacaaag acctgcctga 776401 aacgaacgaa ttaaaaagca tgcggcgtct gacaaaaatg cactgaaaat accaagcgcc 776461 attggcagtg ctttttttgc gtgtctatta tcttaaaagc aagactggag aattcatatg 776521 aaaagaaaac atatcatgat ctatgcggcc agtttgctgg tgtccgttct ggcacacgct 776581 ttttttgtga aagaatgggc ggaaggcagg tatatgacag gtccgggtga cgggcttgcg 776641 caaatgatcg tatttaaaaa attattattt gaccaatata cacacgggaa ttttttctac 776701 aattattcat tcggacttgg cggcggcaca ttcagtcagc tcggctatta tttttctgcg 776761 tcttttcttt ttcttgctgt gtctgccgct gtttggctgc ttcaagccgt ccagctgatc 776821 ggagaaacgg atacgctttt ttgggcagag tcagctgttt ttatcagtat tttcaaattg 776881 agcttgatca tctttacgtc cgcttctgtt tttcattatc ttcttaagca cagggcggca 776941 tcgttcacgg gagccgtgtt atacggcgtc tcaattattt atttccgtca cgaagcgtat 777001 tgggaatttt tcaccgatac aatggtttgg cttccgctgc ttgtgcttgg cgcagaaaaa 777061 attattagag agcggcgtcc ggcgtggttt atcgttgcgt gttcgctgac gttaatcaac 777121 aatttttact ttgcatacat aaaccttata ttcatcggaa tctatgtgct gttcagatgg 777181 ctgatccgtt tggaaccaca tgaagagaaa agatggattc aaatcagatt atttctcgtt 777241 tcaggcttca tttcttttgg catcagtgcg gcggcgtttg tgccggtagt atacggtttt 777301 ttaaacaacc tgcgccctcc atacagccag aaaatagagt ggctcaattt cgatgataat 777361 atcttatttt cgagccggat catcattgtg ccggccgctt ttctgctgtt tttgtttatt 777421 atttcttttt acaaaaaccg tgtgtttcgt ctctttgccg ggttgagcct gctgtttatt 777481 ctgtttcatt tcagtccgta tgcggcaagc gtctttaacg gtttttccgc cccgcaaaac 777541 cggtttgaat atgttctggc ctttaccatt gcgggagcag ctgcggctgg tttgtcacag 777601 ctgtctgaat tgaaacggaa agaactgctc ccggccgcag ctgtcgtcct gcttctttac 777661 ttgtatcata tccaaaggta taagctcgat atatggaagc ctgcgaatga aagtattcta 777721 ttgctcttac tcatgacaat cgcagccttg tttgctgcag cttttgcgaa aaaacgggca 777781 aaaatggctg tgtacggtat aatcattctt tcttcgctgt ttgtcgccaa ctcctatcaa 777841 aaatacgcgc tctcagaagg cggcgatttg gacagtgtga caaaagaata tcttacaagt 777901 gaggaataca gagggcggga atcatctgag ctcatcagac gtttacagaa ggaagacgat 777961 gacccgctca tgagaatcga ctggatgaac ggggtccgca ataatacgcc aatcatttac 778021 ggatttaatg gcttcagcgc gtattccagc attttaaaca aagatctgct ggccttctat 778081 tggaatgatt taagcatcga tatgggcagg gaaagcgtca gccgttacgc gtcattggga 778141 gacagggcga atttatacag cctgctttac ggcaaatatt atatgaccga aaaaacaaac 778201 gaagccagcg tcccgtacgg cttcaaaaag catttagaaa cagagcatta tgcagtttat 778261 gagaatcagt acatgcttcc attcgttaaa acagcggatg ccatatacag cgaaagtgag 778321 ctggaccgat tgcccgctct tgcgaaagaa caggcgatgc tgaaaggaat tatattaaaa 778381 gatccatcag gaaaaacgga gcagacacca aaaccgtcca atttgatcac caagtcggac 778441 atcaccgcaa aacaagccca gtatcaaaac gggctgctaa ccgtaactgg agaaaacgga 778501 ggagagctga tcatcacccc gaaacagcca tcatccgctc cgggagacta ctatgtcagc 778561 ttttatttga aaagcaaagc aaaagacaaa ggatttacat taaaggtaaa tgattatgtc 778621 acaacaagga aatcgaacaa atcgatctat aaaaccggag taaataatat aacggtaaga 778681 gtgcctaaat caggccatat ctcaatcaat cttccgaaag gaacctatga gctgagaaac 778741 atagcgctct atgaagaaaa ttaccaaacg ctgaaaaacg ctgtaatgca aaataaaaca 778801 gagaaagcag acaaactgaa ttggaacaaa aatcgactga ccttttccta tcatctgtca 778861 aaagaccagt acatcatgct tccgatccca tatgaaaaag gctgggagct gaagatcaac 778921 ggaaaaacac agaagatcga aaaagcggat tatgctttta taggcttcaa ggcgcaaaag 778981 ggagacaatc acattgagct gacttactat ccgccatact tcaaaatatc ggcgatcata 779041 tctctcgtca gtctgctgct tgctgttttt tatataagac gtaaaaagcc cggctctata 779101 tagagccgag ctttaatttt ttctgaagtt tttcttcgct gaatatccat cccgtatagg 779161 atgaacgaat cgtgagatca tggccgatat gaacaattgc gacaaacgga taatggcctt 779221 tgctccgata acgcaggtcg ataaatctca cctcataatg atctttaaac gtatccactt 779281 cccaccggta taccggagaa aaggacagaa acgccgcgat gttatcatcc tgctttgccg 779341 catgcattac atcggtttca ggaacaggca cccgattaaa tgtatccaga atcacgacat 779401 gtccttccat gcttcttcct acatagaaag catgtgctgt cgtcactgcg attcgccatt 779461 gcctgaattt catcgttgga gaaataataa tgctttcgat ctcatcatga atcatctcat 779521 gaagcttccg tttaattctc agctgcatga tcaggcgcac caagtagtag cctaccaata 779581 tgatatataa gctgagaaac gtgatgccgg gactcccgcc tgcataccaa atcgcgatag 779641 ctgccagatg gctgataaaa ataaacggat caaacgtatt aatcagcccg agcgcaaccc 779701 attttttcga aaacggacga atggcttgtg ttccataggc gttgaatata tcaacaaaga 779761 catgcagaac gactgccagc agtgtccaca gccacaggtg cagaaaatcg gcctgaggat 779821 aaaataaata cagaatcgcc gggatgatga cagaccaaaa caaaacggcg ggaattgaat 779881 gggtaaatcc tctgtgattc cttatataaa cagcattgtt tttaagcttt aacacagtat 779941 caatatccgg agcctgagag cccgcaagcg ttgcgatcat aacagcgtga gccattgccg 780001 gatctgatcc gacaacagga tcaagcgtcg caataccgcc cagtgcgatg cccataacga 780061 catgtgtgcc cgtatccata ggtgacctcc ttgcagggtg atcctgcaca ttcactttgt 780121 aagaaattcc ccattttcat atacccaatt tttaaactga ttcaatcgtt ctcatatgtt 780181 tccgcttttt ctttattact atttaatgta acatattatc gtactgtgcc cttagtgtac 780241 aacaaaaaac agtctaaaga aaagcggggc gcgaaagact ggggagaaac acatatgaac 780301 gtacttgaag acaaattaaa acaaaaagac atacagcaat ttcgcgatga tttaatctca 780361 tggtttgaac gagagcagcg cgttttgccg tggagagagg accaagatcc atataaggtg 780421 tgggtatctg aagtgatgct gcagcaaacg agagtagaga cagtgattcc ttactttctc 780481 cggtttgtag aacaattccc gacagtggaa gcgctcgctg atgctgatga agaaaaggtg 780541 ctgaaagcat gggaagggct cggctattat tcgcgagtca gaaacctgca aagcgcggta 780601 aaagaagtga aacaggaata cggcggcatt gttcctccag acgagaaaga ttttggcggg 780661 ttaaaaggcg tcggccctta tacaaaggga gcggtgctca gcattgccta caataaaccc 780721 attcccgcgg ttgacggaaa tgtgatgcgt gtcatgtcca ggattctatc tatttgggat 780781 gatattgcca aaccaaaaac aagaacgatc tttgaagacg ccatacgagc ttttatttcc 780841 aaagaaaaac catctgaatt taatcagggc ttgatggagc ttggagcctt gatctgtacg 780901 ccaaaatcac cctcatgcct gctttgcccg gttcagcagc attgctcagc atttgaagaa 780961 ggcactgaac gggagcttcc ggtaaaaagc aaaaagaaaa agcccgggat caaaaccatg 781021 gccgcgatcg tactgactga tgaagacgga caagtgtata tccacaaacg gccgtctaaa 781081 ggtttgctcg ccaacctgtg ggaattcccg aatcttgaaa cacaaaaagg gatcaaaact 781141 gagcgtgaac agctcattgc tttcttagaa aacgaatatg gcatacaagc tgatatcagt 781201 gatctgcaag gtgtagtcga gcatgttttc acccacctgg tatggaatat ttcagtgttt 781261 ttcggtaaag taaaacaagt gtcggatacc agcaagctga aaaaagtaac gaaagaagag 781321 ctcgaacaat ttgcgttccc ggtgtcacat caaaaaatct ggaagatggc aggagaagca 781381 gccgccatct cggctgctcc gtaaaccatt cttaatcgta agagacgcgc gtgccgtggc 781441 tgtagtccgc ttcattgcgc ttcattccgc cgcgcgcttc aatttcttgc gttaattccc 781501 ggtattttga ttggccttct tcgttcaaat aaggcataat ttgctgaaag gcatgatgaa 781561 aataagcgag ttcactgttc ttccaatctt ttttggaaac catgttcaat tcgctcatat 781621 cacgtccgac atacataaca gaagaccccc tttaaagttc ttgccattat tgtttgtgga 781681 aataaaagaa ctatacgcta caaggagatg aggaaaaatg gaacaaaata aatgtgcact 781741 cgtaacagga agcagccgcg gtgtcggaaa agcggccgcg atcagacttg ctgagaacgg 781801 ctataacatc gtcattaact atgcacgcag caaaaaagca gcattagaaa cagcggaaga 781861 aatcgaaaag cttggcgtta aagtgcttgt cgtaaaagca aacgtaggac agcctgcaaa 781921 aatcaaagaa atgtttcagc aaattgatga aacgttcggc agacttgatg tttttgtcaa 781981 taatgccgct tcaggagtac taagacctgt catggaatta gaagaaacac actgggactg 782041 gacgatgaac attaatgcga aagcattgct tttctgcgct caggaagctg ccaagctaat 782101 ggagaagaac ggtggcgggc atattgtcag cattagttca ttaggctcta tccgctatct 782161 tgaaaactac accacggtcg gtgtatcaaa agcagcgtta gaggctttaa cccgttatct 782221 tgccgttgag ctttcaccaa aacaaattat cgtcaatgct gtttcaggcg gagcgatcga 782281 cacagatgcg ctgaagcact tcccgaatag agaagatctg cttgaggatg cgcgccaaaa 782341 tacgccggcg ggacgcatgg tcgaaattaa agacatggtt gatactgtgg agtttctagt 782401 gtcttccaag gctgacatga tccgcggaca gacaattatc gttgacggcg gacgctcact 782461 gctcgtttaa aaatttttaa aaaagaggaa tagctatacg atcacctgca cattctaatg 782521 accgtggagg tgataacaat ggctaactca aataacttca gcaaaacaaa cgctcaacaa 782581 gttagaaaac aaaaccaaca atcagctgct ggtcaaggtc aatttggcac tgaatttgct 782641 agcgaaacaa acgctcagca agtcagaaaa caaaaccagc aatcagctgg acaacaaggt 782701 caattcggca ctgaattcgc tagtgaaact gacgcacagc aggtaagaca gcaaaaccaa 782761 tctgctgaac aaaacaaaca acaaaacagc taatcactga aacagaaaaa agcacttcat 782821 cttcgggtgg aagtgctttt ttctgtttga aaaacgacaa aacttgtgga aggtctacag 782881 aatgagtcaa agggtttgct ttatggagat cgaaatgatt aaaggaggaa atgtttatac 782941 tttcatcagg ctgaaggagg aaccgatgac cgaatttgaa aagctggtaa gtgaacagat 783001 gaaaacgatg gataagcttc tcgatctcca atcagagctc gaccgctgca aacaaattga 783061 ggcggaactc cggcatttgg aaagggatgc aaggctgcgt gggattcagg ctgaaattgc 783121 ggtaaaacgg aaacaccttg ccgatataca ggatatgttt caaaagcaga cagagcaggt 783181 cattcgttca tatcgcagct cagaaaagcc gtcttccttt gtgtagtgca ggaatgtgcc 783241 attccccggc cggaatggct cttttatttt catttttcaa tttgtaacgt tataataggt 783301 aaaagacgtt gtcggtaagc aaatttggac atactaactg tagggcttta tagaaagtag 783361 gggagaaata tgggctatcc caaggaagga gaaaccattc aaattcacag ctataagcac 783421 aacgggctga ttcatagaat ttggaatgag acaacaatct taaaaagtac agaaatgtgt 783481 gtcatcggag ccaatgaccg gacgatggta accgaatcag acggccggac atggataacc 783541 agagagcccg caatctgtta ttttcacgca agacaatggt ttaatgtcat cgggatgctg 783601 agggaagacg gggttcatta ttattgcaac atcagttctc cgtttgccta tgatggcgaa 783661 gcaattaaat atattgatta tgacttagat gttaaggttt ttcctgacat gacctacaat 783721 attctcgatg aagacgaata tgatgatcat cggaaagcca tgaattatcc aaaagaaatc 783781 gacagtattt taagagacta cttaaatacg ctgctccatt ggattcacca gcgtcaggga 783841 ccgtttgcgc ccgagtttgt cgatatgtgg tatgaacggt atttgcgcta tacaaaataa 783901 tggttacgta aaaacctgtt gcggggtaca acaggttttt cacatgggct cacacacatc 783961 atgataaaga gagaggggga atcaaccgtg ggggttatga aacgctacat gcaattcgtc 784021 aaaccttata agaagcaaat tttcgttaca gtgttaatcg ggatcgtaaa attctccatt 784081 ccgcttgctc tcccattgct tctgaagtac gtagttgacg acattattca aggaggcggc 784141 acggccagtg acaaaaccac gtcattgttc acgattatgg cgatcatgtt cgccttattt 784201 ttaattttgc gcccgcctgt tgaatattac cggcaatatt ttgcccagtg gactgccagc 784261 aaggtgcttt atgatataag agctaagctg tttgaccata tacaaaaact gagccttcgt 784321 ttttacgcga atacaagaac aggggaagtc atttcccgag tgattaatga tgtagaacaa 784381 acaaaggatt tcgtcatcac agggctgatg aatatatggc tcgatatgct gacgattttg 784441 attgtaatct ctatcatgct cacactggac gttaaattaa cgctgatctc tatcgtttta 784501 ttcccattat acggaatatc agtgaagtat ttttacggcc gtttacgaaa gctgacaagg 784561 gagcgctcac aggctcttgc tcaagtgcag gggcatttgc atgaacgcat tcaaggcatg 784621 cctgtcatca gaagctttgc gatagaagat catgaacagg ctcaatttaa tgagaaaaac 784681 ggtcatttct tagataaagc catccgccac acgaattgga acgcgaaaac ctttgcggtc 784741 gttaatacca ttacagattt ggcgccgctc atcgtcatag cgtgcgccgg gtattttgtc 784801 attaatggac cgctgacagt cggaacaatg gtcgcgtttg tcggatatat tgacagaatg 784861 tacaaccctg ttagaaggct gatcaattcc tctacaactt tgacacagtc aatcgcatca 784921 atggacaggg tgtttgaatt tattgacgag ccctatgaac tcactgacaa accaaatgcg 784981 ataaaggccg atcagattcg cggaggagtg gagtttcaaa acgtttcgtt tcaatatgag 785041 aaggacaaag aaaatattct tcatgatgta tccttaaaag taaatagagg agaaactgta 785101 gctctcgtcg gcatgagcgg aggaggaaaa tcaacgctcg tcagcctgat cccaagattt 785161 tatgatgtaa caagcggcag actgctgatt gatgggacgg atattcgcga ttatgaagca 785221 agaagccttc gcaaccaggt tggtatggtg cttcaagata cctttttatt tagtgaaacg 785281 attcgggaaa atatcgcgat cggcaagcct gatgccacac ttgaagagat aatcgaagcc 785341 gccaaagctg caaatgccca tgaatttatc atgagttttc cagaaggata tgagacccgg 785401 gtgggggaac gaggcgttaa gctttcaggc ggacaaaagc agcggatctc aattgcgcgg 785461 gtattcctga aaaatccgcc gctcctcatt ttagatgaag ctacatcagc tctggatttg 785521 gaaagtgagc attacattca agaagcgatg gacaaactgg cgaaggatag aacaactttt 785581 gttgtcgccc accgtttatc gacaatcacc catgcggata agattgttgt catggaaaac 785641 gggacaatca ttgaaatcgg aacccatgat gaactcatgg actatgagag ccaatacaag 785701 cacttattta ccattcaaaa tttgaactaa aacatcaatc ttatatcctt ttaacgaagg 785761 atataagatt tttttgtata taaaaaaacc cggctgttta accgggttac tcttctgttt 785821 ctatttcgca gtctttcgga tgatacgttt gaaaacttgt gataagtgtt tctaaatgtt 785881 caagctgctc gcgatattcc acggcgcttg ccataatatt gagcatgttg taatcaataa 785941 gctcctcatc cgtattctgc tgatttttta aaaatgactt tgttaaaagc tgcttatacc 786001 ggatgccttc ttcaaccgcg tcatcatgcg gcttgatttt tccgacaaac ctcatcaaaa 786061 tccgctcgtg ccagtaaagc aggtaatcaa gttcttcagt caatgtttcc tgaaactctt 786121 ccggcatatg atagatctcg ttttccagac gatgcagctt cttcaatgta tcaagcgccc 786181 gatttgcagt aataatggcc tgtctgaaca ggacaagctt tcttgatttc acataagtcg 786241 ttttcttaaa gtaacttctt tcttctttat atagaagata tgtctgatca agcttgatca 786301 ttttttcttt cagtttttca atatcctctt tcaaaatcga atgctctgtc gactgccgca 786361 tggacaatct gatccacttc ataatttctt cggtgttttc gacggtatta tgaatcagct 786421 ttgtttcgta cttaggaggc aaaaacacaa ggttgacgat aaaggaagaa agcaccccta 786481 agatgactgt gcttgttctg atcagcgcga acattaaaaa gtcgtcaccg gcagattcta 786541 atatcgcaat gactgttaca agagcaattg aaattgtatg ttcaatttta agtttcagca 786601 tgattgtaat gacaataact gctgttaacc cgatcataat cgggctgggt ccgaaaataa 786661 ggccgaacac tgtggcaatc acagctccga tgatatttgc ttgaacctgg tcaataataa 786721 tgagaaaaga gcggtaaatc gacggctgga tcgcaaatat cgctgcaatt ccagcgaaaa 786781 tcggcgcggg aagcccgatc cacgaagcca aataaagggc aagtgtaatc gcaatcccgg 786841 ttttgaaaat gcgggcacca agtttcattg gtttgtgcgt gcattccttt ctatagtaaa 786901 ttgtgtgaca tagcaaatgg gctaatcctt aaaattcccg gttagtttat ttgctaaaca 786961 attaagtaat atacagggat cgatacaaat attcaagcta tttttctaga aaaagaccaa 787021 aatcttacac gctgtttgat tccataaaaa aacaggagct caaagctcct gttcaaggta 787081 tttgattcta gttttttaga tgtttaaatg catcctcgac cgctgtaagc gtgtctttaa 787141 tatcctgctc tgtatgtgct gtggtaataa accaagcttc atacttagaa ggtgctaaat 787201 taattccgcg ttccagcatc agcttgaaaa acgtagagaa tgtttctccg tcactccgtt 787261 cagcctgctc gtaattttcc actttctcat cagagaagta taccgtgagc gcacctttta 787321 accggttgac cgtaatggtg atgccgtgtg tttctgcgtg cttcaaaatg ccttcctcaa 787381 gcatagcgcc aaggtgatca agcttttcat acacgccttt ttctttgagc acttccagac 787441 aagcgatgcc tgataggatg gaagcggggt tccctgccat tgttcctgcc tgataagcag 787501 gccctagcgg agctacctgc tccatgattt cttgtttgcc gccataggcc ccaatcggaa 787561 gtccgccgcc gataattttc ccgagtgctg ttaaatctgg tttcacctgt aagagatcct 787621 gcgcgccgcc atacataaag cggaaagccg taatgacttc atcgtaaata acgagagccc 787681 ctgcattatg tgttaattca tttacttgtt ctaagaagcc ctctttcggc tccacgatac 787741 cgaagttgcc gacaatcggt tcaacgagaa ccgccgcgat ttcactgccc catttttcaa 787801 gagctgcttt atagctatcg atatcattaa atggtactgt gatcacttcg tttgcaatgc 787861 ttttcggtac accggctgag tctggtgtgc cgagagtaga cgggccggag cctgcggcga 787921 caagcacaag gtccgaatgc ccgtgatagc agcccgcaaa tttaatgatt tttgtccggc 787981 ctgtatatgc gcgagccacg cggatggtcg tcataacggc ttctgtaccc gaattgacga 788041 atcttacttt gtccatagcg ggaatggctt ctttgagcat ttttgcaaat gtaacctcgt 788101 gtttcgttgg tgttccatac aatacaccgt tctctgctgc ttttttaatc gcttctgtaa 788161 tatgcggatg ggcatgtcct gtaataatcg gaccgtacgc cgctaaataa tcgatgtatt 788221 tgttgccgtc cacatcccaa aaataagcgc cgcttgcttt ctccattgca acaggagaac 788281 cgccgccgac tgctttatat gatctagacg ggctgtttac accgccgaca atgtgctgta 788341 atgcctcatt gtgaagttca attgattttg tatgcaagaa taaaaacctc ctatatctcc 788401 atgcgtcctt tctattgtag catgcttccg aacaagaaca atggcttcgg gcttcagatt 788461 cagctgagat ggttgtaatc tggacaagaa ttggatacgc ttaataaaaa aacatccgga 788521 ggtaacgtaa tgactataga aatcggacaa aaagcgcctg atcttgagtt aaaaggtgat 788581 catggggaaa cagtaaaatt atcggattat aaaggaaagt acatcgtgct ttatttttat 788641 ccaaaggaca tgacaccggg atgtacaact gaagcatgcg attttcggga cagtcacgaa 788701 agcttcgccg aactggatgc cgtcattatc ggcgtcagcc cggacagcca ggaaaaacac 788761 ggaaaattta aagagaagca taaccttcca tttctgcttc ttgttgatga cgagcataag 788821 ctggcggaag catttgatgt gtggaagctg aagaaaaact tcggaaaaga gtatatggga 788881 atcgagcgtt ccactttttt aattgataaa gaaggccggc tcattaaaga atggagaaaa 788941 gtaaaagtaa aggaccatgt agccgaagcg cttcaaaccc tcaaagatat gtctgaaaag 789001 taaatctcta tgagcctatg cttactttta ccctgatatc aattgacaaa ttatcgtaga 789061 aagagttaca ctaattataa acattacaat gtaagaattt tttttagaag agaggtgcat 789121 gacggatggc tgcacatgaa ctaaaagaag ccttagaaac gttgaaggaa accggagttc 789181 gcattactcc tcaacgtcat gcgattctgg aatatctcgt taactctatg gctcatccaa 789241 cagcggacga tatatataaa gctctggaag ggaaatttcc taacatgagc gtagcgacgg 789301 tatataacaa tttgcgtgtg ttccgggaat caggtttggt aaaagagctc acatacggtg 789361 atgcttccag cagattcgat tttgtcacat ccgatcacta tcacgcgatt tgcgaaaact 789421 gcggtaaaat tgtggacttc cactacccgg gccttgatga agtggagcag ctcgctgccc 789481 acgtcacggg cttcaaggta agccaccacc gtttagaaat ttacggcgtc tgccaagagt 789541 gttcgaaaaa agaaaatcat taaaaataag ctgaccgcac gaaacggtca gcttatttta 789601 tttcgacatt ttctttttat tataagactc atcaaattct tttccttcta atcccttatc 789661 taaagtcagc ggctctcggc aatgcatgca catatcgact actcctaaaa cctttgtctc 789721 tttatcacag cctggacaaa tgacgcgaac cgctttagtc gaaagcattc cgatccaaaa 789781 gtaaactacc gtgctgagac cgatggataa aagcccaagt atcataaaca aactagaaag 789841 caaaactgac tctttgaaaa agatcccgat gtacataatg ataaacccaa cgaaaaccaa 789901 acttaacgca aatgttctga ttttattaat tttgctggag tatttcgcca tgtccatccc 789961 cctctgtttt aactatagca caaacccgat gggattttct tcatgttttc ggttgaactg 790021 gaatttacat atggagagtt actgtgaaat tgtttataat agttcaatgt gtttagaaaa 790081 aaggaatttc gttttaacca tagaattgaa tcaaatagag aataaaaaaa tttgaacaat 790141 tgcattggag gaatagtgat ggaaaatctt ctccgtccaa tttaccaaga aagagcaagt 790201 caccccaata cattggctgt cattatgatt gagagaagaa acaaaacatc ttccttaaca 790261 gataactttg atgcagcttt gctggtgatt gtaaaggatg ctgatgagcc agtttttata 790321 aagcattatg aatttgatca tcaaacagct tctttgcatg tggtaacaga ttctcagatt 790381 caagaatgga ttttgcttgg aacaaataga agaatcatag attggattgt aaatggcaga 790441 gtcttgtttg accgtaatga atacgtagtt gaactgattg acaggctgaa tacatttccg 790501 tttgccgaac gtaaactgaa gatcggactc gaatacggca aattaatcag aaggtatgtt 790561 gaagggaaag ctttttttga agccaatcaa tttttagatg cctacaatgc cgttgttcat 790621 gcgctgcatc atttagcacg tattgaagta atcgacagag gattccatcc cgaaaccacg 790681 gtgtggagcc aagtgcgcca gatggagccc caagtgtaca aattatattc cgagctgatt 790741 gaaagtcatg agagcctgga aaaaagactt gaattattat tcttagcaaa tgattttctc 790801 atccattcca aagccgagat cggttcggcg catcttttcg aagtaatgaa agaaaaagac 790861 atttggcaat tcggtgagct tcttcaacat catgacctaa agcactttac ccaagatctt 790921 ggcgttatgc ttgattactt gacggaaaag ggacttatca acgtctgcca gatagaaacg 790981 aaaggacagg ctgtctatca ccgaggatat tcttttaaaa aaggtgttga ctctgattct 791041 tgaccgtgtt atattattaa acgtcgctga tgcgcttctg agaaaacaag ctcacagcgg 791101 cgggaaaata aatcaaaaaa acatttgaca aaagaaagtc aaaatgttat attaataaag 791161 tcgcttcaac aagaagtgaa aatgatcttt gaaaactaaa caagacaaaa cgtacctgtt 791221 aattcagttt ttaaaaaatc gcacagcgat gtgcgtagtc agtcaaacta gggcctgcac 791281 gacgcaggtc acacaggtgt cgccgcagga tgcggtgaac ttaacctgtg atccatttat 791341 cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 791401 agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt aacacgtggg 791461 taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg gatggttgtt 791521 tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttacaga tggacccgcg 791581 gcgcattagc tagttggtga ggtaacggct caccaaggca acgatgcgta gccgacctga 791641 gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg aggcagcagt 791701 agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag tgatgaaggt 791761 tttcggatcg taaagctctg ttgttaggga agaacaagta ccgttcgaat agggcggtac 791821 cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg cggtaatacg 791881 taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg gtttcttaag 791941 tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg gaacttgagt 792001 gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat gtggaggaac 792061 accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa agcgtgggga 792121 gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aagtgttagg 792181 gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg ggagtacggt 792241 cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga gcatgtggtt 792301 taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca atcctagaga 792361 taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 792421 gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt gccagcattc 792481 agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg atgacgtcaa 792541 atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga acaaagggca 792601 gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat cgcagtctgc 792661 aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc gcggtgaata 792721 cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac acccgaagtc 792781 ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg gggtgaagtc 792841 gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa ggatattata 792901 cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt agttttgaag 792961 gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc acattcaatt 793021 agtaatacaa gatatcacat agtgattctt tttaacggtt aagttagaaa gggcgcacgg 793081 tggatgcctt ggcactagga gccgatgaag gacgggacga acaccgatat gcttcgggga 793141 gctgtaagca agctttgatc cggagatttc cgaatgggga aacccaccac tcgtaatgga 793201 gtggtatcca tatctgaatt cataggatat gagaaggcag acccggggaa ctgaaacatc 793261 taagtacccg gaggaagaga aagcaaatgc gattccctga gtagcggcga gcgaaacggg 793321 attagcccaa accaagaggc ttgcctcttg gggttgtagg acactctgta cggagttaca 793381 aaagaacgag gtagatgaag aggtctggaa aggcccgcca taggaggtaa cagccctgta 793441 gtcaaaactt cgttctctcc tgagtggatc ctgagtacgg cggaacacgt gaaattccgt 793501 cggaatccgg gaggaccatc tcccaaggct aaatactccc tagtgaccga tagtgaacca 793561 gtaccgtgag ggaaaggtga aaagcacccc ggaaggggag tgaaagagat cctgaaaccg 793621 tgtgcctaca agtagtcaga gcccgttaac gggtgatggc gtgccttttg tagaatgaac 793681 cggcgagtta cgatcccgtg caaggttaag cagaagatgc ggagccgcag cgaaagcgag 793741 tctgaatagg gcgcatgagt acgtggtcgt agacccgaaa ccaggtgatc tacccatgtc 793801 cagggtgaag ttcaggtaac actgaatgga ggcccgaacc cacgcacgtt gaaaagtgcg 793861 gggatgaggt gtgggtaggg gtgaaatgcc aatcgaacct ggagatagct ggttctctcc 793921 gaaatagctt tagggctagc ctcaaggtaa gagtcttgga ggtagagcac tgattggact 793981 aggggcccct accgggttac cgaattcagt caaactccga atgccaatga cttatccttg 794041 ggagtcagac tgcgagtgat aagatccgta gtcgaaaggg aaacagccca gaccgccagc 794101 taaggtccca aagtatacgt taagtggaaa aggatgtgga gttgcttaga caaccaggat 794161 gttggcttag aagcagccac catttaaaga gtgcgtaata gctcactggt cgagtgactc 794221 tgcgccgaaa atgtaccggg gctaaacgta tcaccgaagc tgcggactgt tcttcgaaca 794281 gtggtaggag agcgttctaa gggctgtgaa gccagaccgg aaggactggt ggagcgctta 794341 gaagtgagaa tgccggtatg agtagcgaaa gaggggtgag aatcccctcc accgaatgcc 794401 taaggtttcc tgaggaaggc tcgtccgctc agggttagtc gggacctaag ccgaggccga 794461 aaggcgtagg cgatggacaa caggttgata ttcctgtacc acctcctcac catttgagca 794521 atggggggac gcaggaggat agggtaagcg cggtattgga tatccgcgtc caagcagtta 794581 ggctgggaaa taggcaaatc cgtttcccat aaggctgagc tgtgatggcg agcgaaatat 794641 agtagcgaag ttcctgattc cacactgcca agaaaagcct ctagcgaggt gagaggtgcc 794701 cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg agagaactct 794761 cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgct ctgttagggt 794821 gcaagcccga gagagccgca gtgaataggc ccaggcgact gtttagcaaa aacacaggtc 794881 tctgcgaagc cgtaaggcga agtatagggg ctgacgcctg cccggtgctg gaaggttaag 794941 aggagcgctt agcgtaagcg aaggtgcgaa ttgaagcccc agtaaacggc ggccgtaact 795001 ataacggtcc taaggtagcg aaattccttg tcgggtaagt tccgacccgc acgaaaggcg 795061 caacgatctg ggcactgtct caacgagaga ctcggtgaaa ttatagtacc tgtgaagatg 795121 caggttaccc gcgacaggac ggaaagaccc cgtggagctt tactgcagcc tgatattgaa 795181 tgttggtaca gcttgtacag gataggtagg agccttggaa accggagcgc cagcttcggt 795241 ggaggcatcg gtgggatact accctggctg tattgacctt ctaacccgcc gcccttatcg 795301 ggcggggaga cagtgtcagg tgggcagttt gactggggcg gtcgcctcct aaaaggtaac 795361 ggaggcgccc aaaggttccc tcagaatggt tggaaatcat tcgcagagtg taaaggcaca 795421 agggagcttg actgcgagac ctacaagtcg agcagggacg aaagtcgggc ttagtgatcc 795481 ggtggttccg catggaaggg ccatcgctca acggataaaa gctaccccgg ggataacagg 795541 cttatctccc ccaagagtcc acatcgacgg ggaggtttgg cacctcgatg tcggctcatc 795601 gcatcctggg gctgtagtcg gtcccaaggg ttgggctgtt cgcccattaa agcggtacgc 795661 gagctgggtt cagaacgtcg tgagacagtt cggtccctat ccgtcgcggg cgcaggaaat 795721 ttgagaggag ctgtccttag tacgagagga ccgggatgga cgcaccgctg gtgtaccagt 795781 tgttctgcca agggcatcgc tgggtagcta tgtgcggacg ggataagtgc tgaaagcatc 795841 taagcatgaa gcccccctca agatgagatt tcccattccg caaggaagta agatccctga 795901 aagatgatca ggttgatagg tctgaggtgg aagtgtggcg acacatggag ctgacagata 795961 ctaatcgatc gagggcttaa ccatattttt gaatgatgtc acacctgtta tctagttttg 796021 agagaataag tttttcaaaa aaacacttga ttttctcaag aatacatagt ataatgttaa 796081 atgtcactga aattgtctgg tgatgatggc gaagaggtca cacccgttcc catgccgaac 796141 acggaagtta agctcttcag cgccgatggt agtcgggggt ttccccctgt gagagtagga 796201 catcgccagg cagacttcat tccgcagtag ctcagtggta gagctatcgg ctgttaaccg 796261 atcggtcgta ggttcgaatc ctacctgcgg agccattatt ggagagctgt ccgagtggtc 796321 gaaggagcac gattggaaat cgtgtaggcg gtcaactccg tctcaagggt tcgaatccct 796381 tgctctccgc cactgatact tatacataat tacaattgaa agtctgggcc cgttggtcaa 796441 gcggttaaga caccgccctt tcacggcggt aacacgggtt cgaatcccgt acgggtcatt 796501 atatgatgga ggattagctc agctgggaga gcatctgcct tacaagcaga gggtcggcgg 796561 ttcgagcccg tcatcctcca ccattatatc atcgcggggt ggagcagttc ggtagctcgt 796621 cgggctcata acccgaaggt cgcaggttca aatcctgccc ccgcaaccaa attttaaaat 796681 ggtccggtag ttcagttggt tagaatgcct gcctgtcacg caggaggtcg cgggttcgag 796741 tcccgtccgg accgccattt gaatacttag gctcggtagc tcagttggta gagcaacgga 796801 ctgaaaatcc gtgtgtcggc ggttcgattc cgtcccgagc caccacctat gccggtgtag 796861 ctcaattggt agagcaactg acttgtaatc agtaggttgg gggttcaagt cctcttgccg 796921 gcactgtttt ttcaaaattt aatgtggagg ggtagcgaag tggctaaacg cggcggactg 796981 taaatccgct ccctcagggt tcggcagttc gaatctgccc ccctccacca tttatagggg 797041 catagtttaa cggtagaaca gaggtctcca aaacctccgg tgtgggttcg attcctactg 797101 cccctgccaa atttatgaca tcttgagatt atggcggttg tggcgaagtg gttaacgcac 797161 cagattgtgg ctctggcact cgtgggttcg attcccatca atcgccccat attatcattg 797221 ggctatagcc aagcggtaag gcaacggact ttgactccgt catgcgttgg ttcgaatcca 797281 gctagcccag tctcactttt tatatcaact gcatataatg tattaagtcc attaaaaatg 797341 cggaagtagt tcagtggtag aacaccacct tgccaaggtg ggggtcgcgg gttcgaatcc 797401 cgtcttccgc tccaattacg gcggcatagc caagtggtaa ggcagaggtc tgcaaaacct 797461 ttatccccgg ttcgaatccg ggtgtcgcct tcttattgcc ggggtggtgg aattggcaga 797521 cacacaggac ttaaaatcct gcggtaggtg actaccgtgc cggttcaagt ccggccctcg 797581 gcaccaattt tacttacatg gtaagttgaa ttggtgtttg tgttttatca ttataactaa 797641 tcatattaat gatctacata agtagatcat ttttttaatg ctttgattta tcataacaag 797701 ttaagttccg aggcctatta taaagcggct gtatagctag tctttcaaca cttttatttt 797761 atatttccat aaaaactttt ttgaaatacg ttgacacttt atgagatcca tgatatattt 797821 atattcgtcg gttagatacg acgtaaaact tgccggtgtg gcggaattgg cagacgcgca 797881 cgactcaaaa tcgtgttcct tctggagtgt cggttcgacc ccgaccaccg gtatactgaa 797941 aaacccgttt cttaacagaa acgggttttt attttttatt aaagaaaagg agcctcggct 798001 cctttttata cttactcagc gtattggtct aggatctctt ctagcacctc ttctagctct 798061 tctgtatctt caagctctga ttggctgaaa cggacgcgta caagctgttc tccgtcatta 798121 tacatctctt ccaaccaccc tcggagtcct cttgctctgc ggtcgacttc gaaaatgatt 798181 tccaaaccgt cttcgtctaa aaggaaaatg agctctaatt catcaagcat ctgacgataa 798241 tatccggaag tcggaacgaa ttcgaattct tgaacgaacg gaagacgacg ctggaagtag 798301 ggcgcttgtt cgcagtctgc ttcgttaaga cggaagccca ggttttcgat tgcttcaagc 798361 acattttcaa tccaagggtg cgcttcaacg aaaatgcggt catgatcgga tttatcgata 798421 ccgccttgaa tgtcaaggtc tgtcaccacg gcaacctcta ctttccctac agtgatcggc 798481 gtatctagag gcagagtgaa tgtgaacgga aattgatgct cttcaccagg ctgtatggta 798541 aatgaaccag tgacccggaa agaatgaatt gtagcgtatt tccggtgctc ttcatcgtct 798601 tttacaatga cataccgtgt gctaagctgt aaatcgatat aacggatgtc ctgagcgatt 798661 tttccgcctt tgacatgtac cgttccctgt acttcttctc ctggaaaata tgcgtctttt 798721 tctaaaattg tatctacttt tgcagctcca attccggcac ttgccgcaag cttcttaaaa 798781 aatgacatgt tagatcttcc cctttttctt ttttctcaac agatatacgt aagaaggagg 798841 aaaaaagatt cgtttgattc atactttttt cctattattc gtctcggcct agggacagac 798901 taagaataat attgaaaata aaggagtcga tggaagtgaa taaagaaagt ttggttgcag 798961 atgaattaca cagaatgttt ttggctggtg agctgcaaat cacagtagag gaggatataa 799021 acaatatttc cgaaaggctg agaaacggcg atctcagttt agaccgatta agcggtgaag 799081 acgtgtttat aaaagaaacg gtaaatgagg ctttaagaag agtggagcaa taaaaaagag 799141 acggcatctc atctttgaga tcccgtctct ttttgtggtc tttgctgtaa gataaaagcg 799201 aatcgatttg gaattgctca cccgagccac cccttttcta acagaagatc tgacagttca 799261 tcatggagat aaacagctgt atctaattga tcatgcaatg ctcttctgat gtggggattt 799321 tcggttgctg ttgttgcgac agtgtatttg ttaatgctgg tttttattgt tgttaacaaa 799381 tcaagaatat ctttgggaca aagactttgt tcaatgggaa accacctcct ttgttttttt 799441 agcagctcct gataagaaag tatttgactt tgtttcttgc ttctatacaa aatgctataa 799501 taagcaacaa attttgttgg ggggtgtgat gatgaagcag attattgcga tggggggcgg 799561 gggtttttcg atggagccgg ataatttgtc cctcgatcaa tatatcctca atcaatcaaa 799621 acgagagcag cctcgtattt gttttttgcc gacggcgagc ggagattccc aaaactatat 799681 tcagcggttt tatcatgcat ttcaaacatt ggattgcgtg ccgtctcatt tatctttgtt 799741 taagccacca tcatcagatt tagtttcttt tgttatggaa atggacgtga tttatgttgg 799801 cgggggaaat acgcggaatt tacttgtgtt atggaaagag tgggggctgg accatattct 799861 cagggaagca tggaagaacg gtgtggttgt agctggaata agtgccggtg cgatctgctg 799921 gtttgaagaa ggggtgacag attcagccgg accgctgaca agtttgaaaa gtttaggttt 799981 tttgcaaggg agcttttgtc cccattatga cggggaaaag gatcggagac cggcatacca 800041 ccagctgata tctaacaagt tcttatgcag tggctatgca gcggatgatg gggctgctct 800101 ccatttcata aatgatcagc tgtttcagac tgtgagttca aggtcgggtg caaaggcata 800161 tcgggtgatg atggctgaac atgaaatagc tgaaatcccg ttgccggtca aatatttagg 800221 gtgaaattgg ctgaatatta tctatattcc tctttttttc agattgattt tatgataaga 800281 tgagtgcgaa atcaatagtt actgggggtg cccgctttcg ggctgagaga gaaggcaagc 800341 ttcttaaccc tttggacctg atctggttcg taccagcgtg gggaagtaga ggaattgttt 800401 ttgttattgt cttgctgggc aataatatgt ttctttctga ctgtaaccgg gttcatttat 800461 atgaatccgg ttttttgtgc tggttatggg cttgattttg tcctttcaaa cgtagaaagg 800521 ggaaggaaaa gtaatgcaaa acaattcagt gcagcaagcc aacatttcca ttatgtcaag 800581 tttttcaggc agcaagaagg tatacgtgga gggttcttct tcggacatcc aagtgccgat 800641 gagggagatt gcattgagtc cgacgacggg atcgttcggc gaagaggaaa acgcgcctgt 800701 gcgtgtctat gatacaagcg gaccgtatac ggaccctgaa gtaaccatta atattcaaga 800761 aggattaaag ccgctccgcc aaaaatggat cacagagcgc ggtgacgtgg aagagtatga 800821 aggtcgggct ataaaaccag aagataacgg ttataaaaaa gcaaaaccaa acgtaagcta 800881 tccaggatta aagcggaaac cgctgagggc gaaggcaggt caaaatgtca cacaaatgca 800941 ctatgcaaaa aaggggatca ttacacctga gatggaattt atcgccattc gtgagcatgt 801001 gtctcctgaa ttcgtcagag acgaggtagc cagcggccgg gcgattattc cttcaaacat 801061 taatcaccct gaaagtgagc caatgattat cggccggaat tttcatgtga agattaatgc 801121 aaatatcggg aattcagcgg ttacgtcatc cattgaagaa gaagtggaaa aaatgacgtg 801181 ggccatccgc tggggagcgg atacgatgat ggatctctct accggaaaag atattcatac 801241 gacgcgtgaa tggattatcc gcaattgccc cgtgcctgtg ggaactgttc cgatttatca 801301 ggcgcttgaa aaagtaaacg gcgtagctga ggatttaacg tgggagattt atcgtgatac 801361 gctaatcgag caggcagagc agggagtgga ttattttacg attcacgcgg gtgttttgct 801421 taggtatgta ccgctgactg ccaaacggac aactggtatc gtgtcacgcg ggggagcgat 801481 tatggcgcag tggtgtctgg ctcatcatca agaaagcttt ttatacacac attttgaaga 801541 aatatgtgag attatgaaaa tgtatgatat tgctttctct cttggggatg gtttgcgtcc 801601 cggatcaatt gctgatgcca atgacgaagc gcagtttgct gaattagaga cgcttggaga 801661 gctgacgcaa attgcctgga agcatgatgt tcaggtgatg attgagggtc ctggacatgt 801721 tccgatgcat aaaatcaaag agaacgtcga taaacaaatg gacatttgta aagaagcgcc 801781 tttttacaca ttggggccgt tgacaacgga tattgctccg ggatatgacc atattacttc 801841 agcgatcgga gcggcgatga tcggttggta cgggacagca atgctttgtt atgtaacgcc 801901 gaaggagcat ttggggctgc caaaccgtga tgatgttcgt gaaggagtca ttacatataa 801961 gatcgctgcg cacgctgcgg accttgcaaa agggcatccc ggagcgcaaa tccgggatga 802021 tgcgttatcg aaagcccgtt ttgaattccg ctggcgggat cagtttaatt tatctcttga 802081 tccggagaga gcccttgaat accatgatga aaccctgcct gctgaaggag caaaaaccgc 802141 tcacttttgt tccatgtgcg gtccgaaatt ttgcagcatg agaatttcac aggatattcg 802201 ggattatgcg aagaaaaacg atctcagtga agcagaagcc ataaataaag gattaaaaga 802261 aaaagcaaaa gagtttgtcg atacgggaag caatttatat caataaaaaa aatgaagatg 802321 gagaatgctc catcttcatt tttttagaaa aacagagagc gtcgaagcgg aggaatactc 802381 tgttcaaagc ggaaaacatt ttctggatca tatgtcgttt tgacacggcg gagtcgttca 802441 acgttttcgc cgtaatatgt tcttggccag tttctgattt cgatatctgg ccaatttacg 802501 tagtctccca tcgtttcttt cgaaagggac gttctcagcc cctcaatcca gcggacattt 802561 tgtctttttt ctccagggga tgtccagttt gttaagtatt cctgggcgat gattgcgtca 802621 cgataataaa atgccgtttg gtcgggagcg acccgtccgg ctgccccgcc gagtgcttgc 802681 tgccagacac tggcgttttg attcggagcg tgctctaaaa agtgttttat tgttgagatc 802741 gcacgttctg ataatggctt ttcaatgaaa gagccggagc gtttcatttt ttgaggctga 802801 ttgcctcccg ggctgttaaa aaaggttacc gcttcaatga atggcgttgt ttttaccatt 802861 ccgcttgtcg gacttcctgc tttcaataaa ggctttaaca gtttttttaa ctctgttttt 802921 ggcccgacaa attggccgag ggcttctatg cggtttactt ctttaggcca aaactctatt 802981 gatgatgtaa gccggtcatc tgtatacggg gcccagttct gccacgtgtt atatacttcc 803041 tcaaaatcat cccatcccca tgtaatagaa aaaatcgaca cttgagagat gggcactgct 803101 ttaaatgtca tggaggtgac tatgccgaaa ttgcctcctc cgcctccctg agacgcccaa 803161 aataagtctg gatgatttga acagctgact gtaatcagat cagcgccctc tttttcgtct 803221 gctacgatca tctcaagctg cacgaggctg tcgcaagtaa gaccggcagc ccttgttaaa 803281 agtccaattc cccctccgag agttaaacct gtgagcccta cattagcaat ggtgcctgcg 803341 ggaagcgtca ggccgtattg ccagagtgtc cgatagactt ctcccaattc agcccccgct 803401 tcaatatagg ccagcttttt atcctgattc acagttattt ttttcatctc gcttaaatca 803461 ataacaagac cgttatttaa aagggaaaag ttctcatagc tgtgtctgcc gcctctaata 803521 cggaaaggca cacggttttc acgcgcccat ttcagcgcat tgagtgcatc ctgtttgttt 803581 tggcaaaaca caatgatgtc aggatacctt tctaagctta ggttaatatt ggttcttgct 803641 tcgttatagt ccggatcatc ccgtgtcacg atacgtccgg tcaattttgt cttttccaca 803701 ctcccacatc tctttctctc gtattctagt ttctctagct tatgcgtcag gggaaaagag 803761 tgtataagga aaaagcgggg atgcaatctg atacagtgtc aacaccctca aaaaatagtt 803821 gacaggtcgg tattgtatga attaacatgg tcagtacaaa tttttcaaat ttatcgcgct 803881 gatcggaaca ccgaaggctc ttatcgttta gataagggcc ttttttgtat gaaaaagggg 803941 ggattattga tgggagtcaa aaaagaaaag gggagaaaac gattcaggaa gcgaaaaacc 804001 tacgggaatc agattttgcc gcttgagctg ctgattgaaa aaaacaaacg agagattata 804061 aacagcgcgg aactcatgga agaaatttat atgaagattg atgagaagca tacgcaatgt 804121 gtaactaaat ataaaaaaac ccgctgacta caacgggttt ttgcatttct ccattaagaa 804181 tcttttttaa tcggcaatcc aaggccttct gccacgcgtt ttccgtattc aggatccgct 804241 ttgtagaagt gctcgatttg gcgcagcttg atttcttctt tttctaccgg cttcatggca 804301 ttaacgatat tttcaacaag gcgggtacgt tcatcttcac tcattaaacg atacagatcg 804361 ccggcttgag tgtagtgatc gtagtgatcg tagcttacgc tgtcagcgat accttgtacc 804421 ggatatgctg cttgcttatc ctcaggtgac tcttttggac cgccgaagct gttaggctcg 804481 taatacacag atccgccgcc gttatcatca aaacgcattt gcccatcacg ctgataattg 804541 tttactttgt tgcgtgcgcg gttgattggc agcgcttgat ggtttgcacc gacacggtag 804601 cggtgtgcat catgataagc aaaaagtcga ccttgaagca ttttatccgg tgaaacatca 804661 ataccaggca cgagggttcc aggtgaaaat gtcgcttgtt ctacctctgc aaagtagttt 804721 tccggatttc tgtctagaac catgcgtccg acctcgatta acgggtagtc tttttgagac 804781 caaacttttg tgacatcaaa cggatcgaaa cggtacgtat ttgcatcttc taaaggcatg 804841 atttgcacat atagtttcca tgcaggataa tcaccgtttt cgattgcgtt gaaaaggtct 804901 tctgtatggt aatcagggtt ttcaccggca atttttgctg ccgtattgac atcaaggttt 804961 ttcacgcctt gttctgtttt aaagtgatat ttaatccata cgccttcgcc ttcggcattt 805021 gtccatttga atgtatggct tccgaagccg tgcatgtggc gaagtgtcgc aggaattccg 805081 cggtcagaca tcaggattgt cacttggtgc agtgactctg gtgaaagtga ccagaaatcc 805141 catacagccg tagggttttt caggtgtgtt tttggatctc ttttttgtgt atggatgaaa 805201 tcagggaact taatcgcatc gcggataaag aatacaggcg tattgttgcc gacgatgtcg 805261 tagtttcctt cttcagtata aaatttaaca gcaaatccgc gcgggtcgcg aactgtgtca 805321 gcagagccaa gttcaccggc aactgttgag aaacggatga acaacggtgt gcgtttgccg 805381 acttcagaaa ggaaagcggc tttcgtgtat tttgttacgt cgtttgtcac ttcaaaatat 805441 ccgtgtgcgc ctgctccttt ggcgtgaaca acacgttcag gaacacgttc tcggttgaaa 805501 tgggccaatt tttcgagtaa atgtacatct tgaattaaag ttggtccgcg agaaccggca 805561 gtcattgagt tttgattatc tccaaccgga gcgccccagc tagttgtcag tttatttgaa 805621 ctcatgttat cacctcttgg aatttataag aacataatat catctctaag taaaaagtca 805681 atattatttt ataattatta taaaatagtt atctctatta atcgatatat agtatcgaaa 805741 ttgttgaaaa accttgttgt aacagctttt tatgacactt aataattttt ggagaaataa 805801 tttttccttc tctatttgcg aaacaagcag agtaagtgat aaacaaggat atcaaaaatc 805861 gtatttaaaa aagagttgac atatcggaat aatttgaatt aacatgttat tcaaacaaaa 805921 aaacaattgg gcagctgatc ggaccgccga aggctctcat ctctacaaga acagagatgg 805981 gggccttttt gttttttttg aaggcggggt tggcagaaag agagggataa aagtggctgt 806041 gaccatcagc atcaaagaaa aggcatttgt tcaagaaggc cgcaaaaaca cggtcttaga 806101 aaacatagaa ttatcaatcg caccaggcga atttctaacg cttatcggac cgagcgggtg 806161 cggaaaaagc accctgttaa agattattgc agggcttgat tctgaatatg acgggagtgt 806221 ggaaattaac ggccgcagcg taacagctcc gggtattcag caaggattta tttttcagga 806281 acaccgcctc tttccttggc tgactgttga gcagaatatt gcagccgact tgaatttgaa 806341 ggacccaaaa gtcaaacaaa aggtggatga actgatcgag attgtcagat tgaaaggatc 806401 ggaaaaagca tatccgcgcg agctgtcagg cggcatgtca caaagagtag ccatcgcccg 806461 ggccctgctg cgggagcctg aggtgctgct tttagatgaa ccgtttggtg cactcgacgc 806521 ttttacaaga aaacacctgc aggacgtgct gctggatata tggaggaaga aaaaaacaac 806581 gatgattctc gtgactcatg atatagatga atctgtttat ttaggaaatg agcttgcgat 806641 ccttaaggcc aaaccgggga aaatccataa gctgatgccc attcacctgg cgtatccgcg 806701 aaaccggacg actccggatt tccaagcgat cagacagaga gtgctgtcgg aattcgagaa 806761 aacagaagat ttggagtacg cagaaggatc agggatatag aaagggcgga agcggaaatg 806821 aaaaaaggac tcattgtatt ggttgccgtt atttttctgc tcgcaggctg tggagcaaat 806881 ggagccagcg gtgaccacaa acaattgaag gaaattcgta ttggtattca gcaaagctta 806941 agcccccttt tgattgcaaa agaaaaaggc tggttcgaag atgcatttga aaaagaaggc 807001 atcaaagtga aatgggtgga gtttcaaagc ggtccgcccc aatttgaagg ccttgcggca 807061 gacaaacttg atttttctca agtcggtaat tcgcctgtga tcgctggaca ggcggcaggc 807121 attgacttta aagaaatcgg tttgtctcag gacggcttga aagcaaacgg catccttgtc 807181 aatcaaaaca gcggcattca agacgttaag ggcttaaagg ggaagaaaat tgcagtcgcc 807241 aaaggcagca gcgggtttga ttttttgtat aaagcgcttg atcaagtggg gttgtcagct 807301 aacgatgtga caattattca gcttcagcct gatgaagcag cttccgcatt tgaaaacgga 807361 tctgttgatg cctggtccat ttgggagccg tacttgtcct tagaaacaat gaaacacgga 807421 gcaaaaatcc ttgtgaacgg agaaagcaca gatttatatt caccgggttt tactttagta 807481 agaacaaagt tttcagaaga gcatccagac gaagtggtcc gttttctgaa ggtgtttaat 807541 aaagccgttg tatggcaaaa ggaacatctg gatgaagcag cggacttata ttctgacatt 807601 aaagatctcg ataaaaaggt cgtcgaaaat gtgctgaaaa atactgagcc acttaatgag 807661 atcatcagtg acgacattgt gaaagcacag caggaaacag cagattttca atttcgaaca 807721 aaggcgatag ataagaagat tgatgtgaag gatgttgtcg ataacacttt tatcaaaaaa 807781 gcattagagg agcattcctc aggaggtgat caatgatgaa agcagaggct gcgggctcgc 807841 tgcccaaaac gaatgcggaa gcggtgcgaa aaaagcccgg aaggaagaga tacggctgga 807901 tgaaggggct tttactgccc gctgtcatca ttgccatctg gcaggtcatc ggcgggctgg 807961 gggttgtgtc cgctacagtg ctgcctacac ctgttacgat tgttctgacc tttaaggagc 808021 ttattttgtc cggcgaactg ttcggccatc tgcaaatcag catttatcgg gcggcacttg 808081 gttttttgct tggcgcgggg cttggattga tgatcgggat tttggccgga ttttccaaac 808141 ggacggagct gtatcttgat ccgtcgttgc aaatgcttag aaccgtacct catctggccg 808201 tcacgccgct gtttatttta tggttcggat ttgacgaagt atctaaaatt ttgctgattg 808261 cgctcggtgc cttctttcct gtctatatca atacgtttaa cggcatccgc ggggttgacg 808321 cgaagctgtt tgaagtcgcc cgggtgcttg aatttaaatg gcatcagcag atatccaaag 808381 tgatattgcc ggcagccctg cccaatatat tgctaggcat tcgcttatcg ctcggcattg 808441 catggctcgg gctcgttgtg gcagagctga tgggctcaag ctcgggagtc ggctatatga 808501 tcatggatgc gagacagttt tcacaaacga ataaagtctt tgcagggatt atcatttttg 808561 cagtggttgg aaagctgacg gattccttcg tcaggctgct tgaacgaaag ctgttaaagt 808621 ggagaaacag ctacgaagga taaaagatat aaaggggaga tgaatatgga aattctttgg 808681 tttataccga ctcatggaga cgcgagatat ttaggatctg aaagtgatgg acggactgcg 808741 gatcatcttt actttaaaca agtcgcgcag gcggcagaca ggctgggata tacaggagtt 808801 cttctgccaa cgggaagatc gtgcgaggac ccgtggctta cagcgtcggc actggcagga 808861 gaaacaaagg acttaaagtt tttagtcgcg gtaagacctg gtttaatgca gccttctctg 808921 gcagccagaa tgacatccac cctagaccgc atttcagacg gccggctgct gatcaacgtt 808981 gtggcagggg gcgatccgta tgagctggca ggcgatggcc tgtttatcag ccatgatgag 809041 cgctacgagg caacagacga atttttaacc gtttggcgga gacttttgca gggagaaacg 809101 gtttcctatg aaggaaagca tataaaagtg gaaaacagca atctgctttt cccgccgcag 809161 caagagccgc atccgcccat ctatttcggt ggttcgtcac aggctggaat tgaagctgcc 809221 gcaaagcata cagacgtgta cttgacatgg ggtgagccgc ctgaacaagt aaaagaaaag 809281 atagaaagag tcaaaaagca agcggcaaaa gaagggagat ccgttcgatt tggcattagg 809341 ctgcatgtca ttgcccgtga aactgaacaa gaggcatggg aagcggcaga gcgcttgatc 809401 agccacttgg atgatgacac cattgccaaa gcgcaggcag ctttgagccg ttacgactct 809461 tcaggccagc agcggatggc cgtccttcat caaggcgatc ggacgaagct tgaaatcagc 809521 ccgaatctgt gggcggggat cggcctggtc agaggagggg caggaacagc tcttgtcggt 809581 gatccgcaga cgattgccga ccggatagcg gagtaccagg cactcggcat agaatcgttt 809641 atattctccg gctatccgca tttagaagaa gcgtattatt ttgcagagct tgtatttccg 809701 cttttgccgt ttgaaaatga tcggacgaga aagcttcaga acaaaagggg agaagcggta 809761 ggaaacactt attttgtcaa agagaaaaat gcatgagttt aactaaaata cagccccccg 809821 aacatggtat gatattcaaa aaaagggggc tttttttctg aaaacattga gaagcgcggc 809881 agtcatttgc ctcatagcta tgctgtcagc atgcggacat tcaaaacaga tggaaatcaa 809941 agcggcggac atatcagatc ttgaaaaaaa cagaatggat gtcgcagctt cacaggcatt 810001 cactgccgaa gccgtcaata tcggtgaagg tatttcttca gctgacatgt acatcgaaca 810061 ttatcaaaag ggaaagcttg ttgagaggtt tggaccggtt cgtgcagatt attcagagga 810121 aaaaactgat accatacaat ttgtttattt tgagaatgaa gagggggaag gaaagaataa 810181 acataccacc attcattttg gcattgtgga taaacaggga actatagcgg ctgattcatc 810241 ggtgaaacgc gacgatagca caacacagga aatgactcag aatatttcat cgccggaacc 810301 gattactttc gagaagcctg ctttgatcgg cagcagtatt agagggactg acgagacaat 810361 gcacacctct gaacataaaa aagagctcat taagcatcaa gatgcgttac tgtattatgt 810421 ggaattgcat cattagaatg ggcggcttca ggccgtctgt tttacaaagc ggtatgcttg 810481 cttttttgaa tggtgaatga tacattttaa atcgtaacaa tttcgattta aagggaggct 810541 atgtgacttg gctaaaaaat caaaagtggc aaaagagtta aaacgccaac agcttgttga 810601 gcaatacgct ggtattagac gcgagttgaa ggaaaaagga gattacgagg cactcagcaa 810661 gctgccaaga gattcagcac cgggaaggct tcacaaccgc tgcatggtaa cggggcgccc 810721 gagagcatat atgaggaagt ttaaaatgtc cagaatcgct ttcagggagc tggcccataa 810781 aggccagatt cccggtgtga aaaaagcaag ctggtaagaa aaaactccgg ccgattacag 810841 cgcgccggag tttttttcgt ttttcttgaa agagatgacg taggaaaggt gctggatgat 810901 catgatgata aacacaataa taatagggaa aaacggaatg cgcgattgaa atagcggata 810961 aaaaatgaga agaaccgctg cggcaggcag cgagaagtag acagcgatat atgacgcgcg 811021 acatgctttt gccgtcatca tctgctctct ttcatcctgc tcttcaaact catcaggcag 811081 aagtagctgc tttctggcag ggcggctttt tttctgtaag tacaaataaa ccgcagacgc 811141 cgcaacaaac agaataaagg gagtgaggtt taaatcaaat accatcccgc cgctctttgt 811201 gccgaaaaaa gatgctatgc cttctgaggc ttcaaagtat gaaatcagcg cccagcatgc 811261 aaggccaaat aaaacaaggt gaaaagctgc ttttgttttc atgctcatct tagttttcct 811321 cctctaacca aaagacatcc tccattttca tggagaaggc tttgcagatt ttcagtgcta 811381 acagcagtga gggaacataa tcgccttttt caatcgctgc cacagtctgt cttgtgacgc 811441 cgaccgtttc tccgagtttt tcctgagaat agccgaagcg tgccctcagc tcttttactt 811501 tatttttcat catgacgtct gtccccttca caatctcgat tgattatatt gtatagtata 811561 cttaacatta tgtaaatgga acttaacaac tttacaaaaa gataactttt tttcgacaaa 811621 atttttatat tcccttgacg aaaaataaat aaacatgtaa tataaaaaaa gtcagagcgg 811681 tactgttgct gacaatcaca aatgcgggtg tagtttagtg gtaaaacctc agccttccaa 811741 gctgatgtcg tgagttcgat tctcatcacc cgctccatac atacgttatt aacgcagtgt 811801 ttcgtttctc agataaacga agtattgcgt ttttttatgt gaaaaagaac acggtattcg 811861 tgttctttta cgtaagccaa tgtactgtat gggtgccgcc gtgaatttgt tcaaacattt 811921 tcgttaatga tgataagagg ttaacagcgc tgcttttctc aatcgatggc gggaaaaaaa 811981 tgatttgcag catattctta gtctcgtttg aaacgggata gtggttgacg ctgtttttga 812041 aatcgccaaa aatgccgttt tcatcagaga aaagcagtat gttttctttt tctcccaatg 812101 agatccggac cggctcatga agctttccgg catcataaat cataataggc agagaatatt 812161 ttaatgcgaa aaaatcgatt gtgtcatggg ccgagtcttt actttccatg aattgttcct 812221 tggatatcgg gaccagcatg tcctccattg gggttgtttc tccctcaaat gaagggttaa 812281 gctgtttaaa gagtttctgc cattccttga cgaaggattc atcggatata ccgccgtccg 812341 catagtcgaa aaacaaggat tcttgaaaca ggcggagtct gcctttcagc atttgcggtg 812401 aggagccgac ttcgatattc tcataaatga cagcagctgc atgtaagccg gccgcacgtt 812461 cagtaataac agaatcaagt ttgatattca ctagcattca ctccagttac gtgatatcaa 812521 cctattataa acgctgtgtc gttttatcac aaagaaagga ggctgtgcaa aacatgaacg 812581 tttatcagct caaagaagaa ttaattgaat acgcgaaaag cattggcgta gacaagattg 812641 gttttacgac cgctgatact tttgacagtt taaaagaccg tttgattctt caagaatcac 812701 tcggctatct ctccggcttt gaagagccag atatcgaaaa aagggtgacg ccgaagcttc 812761 ttttgccgaa agcgaaatca atagtggcaa ttgctctcgc atatccttcc agaatgaagg 812821 atgcgccgag aagcacgaga actgagcgca ggggcatttt ttgcagagct tcctggggaa 812881 aagactatca tgatgtgctg agggaaaagc ttgatctgct ggaggatttt ctaaaaagca 812941 agcatgagga tatcagaacg aagtcaatgg ttgatacagg tgaattgtct gatcgcgccg 813001 ttgcggaacg tgccggaatc ggattcagtg cgaaaaactg tatgatcaca acacccgagt 813061 atggctctta tgtgtatttg gcggaaatga tcacaaatat cccttttgag cctgatgtgc 813121 cgattgaaga tatgtgcggg tcctgcacga aatgcttgga cgcctgccca acgggagcac 813181 tggttaatcc cgggcagctt aatgcgcagc gctgcatctc ttttctgacc cagacaaaag 813241 gatttttgcc tgatgaattc cggacaaaaa tcggaaaccg cctgtacggg tgcgatacgt 813301 gccaaacggt atgccctctc aataaaggga aggattttca tcttcatccg gaaatggagc 813361 ctgatcctga gattgccaaa ccgttattga agccgctttt ggccatcagc aatcgggaat 813421 ttaaggagaa attcgggcat gtctcaggtt cttggcgcgg aaaaaaaccg attcagcgaa 813481 acgccattct cgcgcttgcc cattttaagg atgcttccgc actgcctgaa ttgacggaac 813541 tgatgcacaa ggatccgcgt cctgtcatca gggggacagc cgcatgggca atcggaaaaa 813601 tcggagaccc cgcctacgcg gaagagcttg aaaaagcgct ggaaaaagag aaggatgaag 813661 aggcaaagct ggaaattgaa aaaggaattg agttgctaaa agcttcaggc atgactaaac 813721 aaggcctgtc ctgacatacg tatagagcag aaggaaaaaa cacttgagat catccaagtg 813781 ttttttctct ataaaaaagt atggcgggtg gggtgagctt gaagtacatt ttagaacaat 813841 tagcggagga gcggctgggc tttctggtta acgggcatgc tatgagacag gagtctcaag 813901 tcggagacct taaagtcatg gagcgtaaga aaaagcttct ggaaaaacgt aaagttgaca 813961 tcataaaagc gaaagcaaag gccgtgatta atcatgtgcg ggttgaggat gacggaacga 814021 cctgcctttc gtataccatc cattacgaat acgtgtgtaa ggaacaagat gacagcttgt 814081 atatagaaga gcacatagag gagcgaatgg ctttcctgta tgatcacatt ttgattagtg 814141 atcaggaaat tgcgaaaaag ccggctggat ttcatgaagg gaccagtatt attgactatt 814201 ctgaagctga agaggaaaga gaagcgtttg gcagggcttt tcaatacgat cgtctcggcg 814261 ctgtccaata tgccgagaaa ttttggaaca agcgcaatcc tgcttataaa aatttcagcg 814321 ataactgtac aaattttatt tctcagtgtc ttcatgcagg aggcgcgccg atgcgcggtc 814381 atccgaacag gggatcaggc tggtggatga aacaaagctc atggagctac agctggacgg 814441 tggctcactc tatgaaaatg tatttgtcga attcaaaggc cggactgcgt gcggtgcggg 814501 tgaaatcagc ggaagaactg atgccgggcg atgtgatttg ctatgacttc gaaggagacg 814561 gccggtttaa tcatacaacg attgtcgtgg caaaggacaa aggcaatatg ccgcttgtca 814621 acgcccagac ttatgacagc aggatgaggt attggtcata tgaggattct acggcataca 814681 cgccgtcaat acgatatgcc ttttttcata tcgttgatga tacgacaaaa gagtaattaa 814741 tgttataatg atgggcggat aagaaaaaca gaggtgaaca ttgtggcatt acatgtcgtt 814801 ttatatcaac cagaaattcc cgctaacaca gggaatattg cacgtacttg tgcagcaacc 814861 aatacaacgc tacacctgat tcgtccgctc ggcttttcaa cggatgataa aatgctgaag 814921 cgtgccggac tcgattattg ggagtttgtt aacgttgtgt atcatgattc gttagaagaa 814981 ttgtttgagg catataaaaa aggcaagttt ttctttatta caaaatttgg ccagcagcct 815041 catacatcat ttgattacac tgatcttgac gaggattatt tcttcgtgtt cggaagagaa 815101 acaagcggtt tgccaaagga tttaattcaa aataatatgg accgctgcct gcgtcttccg 815161 atgacagagc atgtcagatc gttaaatctg tccaatactg ccgcgattct tgtttatgaa 815221 gcgctgcgcc agcaaaatta ccgtgattta aaatagtgaa aaacccgctc atcgatgatg 815281 ggcgggtttt tttgcggatg ttgaaatgct ttgtttcgtt tttgggctta acaacgtaac 815341 agtgttatgt tacaatgtac ccatcaaagg agctggactt atggaagaac aattaatctc 815401 taaaaaagaa ttacttgaaa gaacatcgat ttcatacggt cagctgtatc gatggaagcg 815461 gaaaaactta atacctgagg aatggtttat tcgtaaatcc acatttacag ggcaagagac 815521 gttttttccg agagaggaga ttttaaaacg tatatcaatg attcaaaaga tgaaagaaaa 815581 tttgtctttg gatgaaatga gggaaatgct gtcgccgaaa atgaaggatg tcagcatgac 815641 cgctgatgaa ttgcttcata aaggtttggt ttcaaggcct gctcttgaag cctattcaga 815701 agacggagga agtccggttt tttcatccag cgatttgctt tcgctgtttg tgcttgaggg 815761 cctgctgcag tctggaaatg tcagccttgc agaagcaaaa atggctgcag aggtattaaa 815821 gaagcatgat actgaagaga ttgaaaaaca gacggagctg attgtgctcc gcaagctcgg 815881 tgtcacaact tgttttatag cggctgcggc ggacagcatt ttgtttgaat catccgtaaa 815941 ggttgtggaa cgggtagatt tattaaaagc ttcagaggaa ttaaaaacaa catttatgca 816001 ggagggccat caatggatgt agtggaaaag ctggtgataa atggatcagg aagttctaag 816061 ggaggaacat ttcaatcagt tgagattaat ggcagcggga cagtggccgg ggacgtggag 816121 tgtgacactt tttcttttaa tggaaacgga aaagcggacg gcagcgtcaa agcgaaagcg 816181 gtaactatca gcggttcagg aaagatacat ggagacgttg aagcagaatc tatccggatg 816241 aatggcactg gttttattca aggagaggta tctgcaaaac aattgaaaat cgctggatca 816301 tcaacatttg gcggcactgt caaggctgat ggaattgaca ttagcggaaa agctgtcatg 816361 gaagcagatt gtgaaacaga aacctttcaa tcagaaggga aatgcaaaat cagcgggctt 816421 ttaaatgcag accaggtgat cattaagctt tctgcagggg aaagctatgc gcgggagatc 816481 ggctgccgcc atcttcaagt gacctgcaga aaaggaatgc tgacattgct cagattgatg 816541 ccgcagcctg ttctaacagc agagctgatc gaaggtgacg tgattgaatt gacaaataca 816601 aaggcgaaaa ccgtgcgcgg taataaagtg atcatcggcc cggattgcca gattgaaacc 816661 gtcgaataca gcggggacta tacctgtgat ccaagcgcgt cggttgaaac atccacaaag 816721 ttgtaaggag gatcgtaatg gagacaacaa aactgggaaa tttaaaatta tatggcgctg 816781 ggcatgccgc aggaggcgcg tatcacaatg tcagcatcaa aggagaaggt atagttggag 816841 aagggctgtc tgctgtaggc tgccgcatat acggaacggg cctttttctc ggaaaagcag 816901 agactgagcg gctgcgtgtg ctcggagaaa gtgaatgtaa aggcgatctg acagccggca 816961 aaatcaatat atatgggaca atgaaagtca gcggctcact tcaatttgat cgattcaatc 817021 tgaaaggcca gactgaaatt ggcgggaata tgactggaga atcctgcgat gtgaaaggga 817081 agcttagcgt aataggtgat tgtgaaacag aaatgttcca tgtcacaggc tgtgttgatg 817141 tatcggggtt attaaattcg ggtgagatca agctgggatt gagccatgat ataagccatg 817201 tgcaggaaat cggcggaaca acaattacag tgaaaagacg cgcgagtttt tttagccgga 817261 agaaagggaa gctgatcgcc gatgtcatag aaggagatcg ggtttatttg gagaataccg 817321 aagcggcagt tgtcagggga aaagaagtga tcatcgggcc gggatgcagc atcggaacga 817381 ttgagtacga atacaaatgt gaatgcgatc cgcattcaca gattaaagaa aaaacaaaac 817441 tgtaaaacat tgttctgtta tacaaaaagg gtgctctttc aggagcaccc ttttttattc 817501 ttttccaggc ttgctttcgt atcctgcggt aaaaattgat actaaaaaag tgacaatgac 817561 acccatcatg atgattgttt tcaccgtctc tccccctctt caatttttcc gtgctgtccg 817621 agtctggatg attctgtatt tttctttatt atgaacggtc gcagtctgcc ttgtcaacga 817681 tgtatgagta tctttatttt taagaaacca aagcatgtat cacgagatgg cggcatagat 817741 tgtatcaaag taccttattt gcatagtgta tcaaacatga tagaggaggt ccttatggat 817801 atattaaaga aaattgaaaa gtacagagag gaagagcagc ggctgaaatg ggaaggaact 817861 ttcgccgatt atttggagat tattaaagaa aatccgatgg tcgcgcaatc tgctcattct 817921 cgagttttta atatgataaa agacagcggg atagaggaga ttgacggacg caagaagtac 817981 agtttttttg accgcgagct gttcgggctt gaagaatctc tggagcgtct tgtggaagag 818041 tattttcatc cggctgccaa acgtctagat gtcagaaagc ggattctatt gctgatgggg 818101 cctgtgagcg gcggtaaatc cacgctggtc acaatgctta aaaaaggtct cgaagcgtac 818161 acgctgacag ataatggcgc tgtatatgcg attaaaggct gcccgatgca cgaggaccct 818221 ctacatttaa tcccccatca tttacgcgat gacttttaca gagaatacgg cattagaata 818281 gaaggaagtc tttctccttt aaatgtcatg aggctggagg aagagtacgg aggaagaatt 818341 gaggatgtga aggtggagcg catcttcttt tcagaagata agcgtacggg aattggaaca 818401 ttcagtccct ctgatccgaa atctcaggat attgccgatt tgacggggag tattgatttc 818461 tcaacaatcg ccgagtacgg ttcagaatca gatccgcgcg cttatcgatt tgacggagag 818521 ctgaataaag cgaaccgcgg gatgatggag tttcaggaga tgctgaaatg tgatgagaaa 818581 tttctctggc atttgctttc cttgacacag gaagggaatt ttaaagctgg gcggtttgcg 818641 ttaatttctg ctgatgagct gatcgtggct cacacgaatg aaacggagta tcgctcattt 818701 atttctaata agaagaatga agccctgcac tcaagaatca tcgtgatgcc ggttccttat 818761 aatttaaaag tgtctgagga agagagaatt tatgaaaaaa tgattgcaga aagcgatgtg 818821 gcggatgttc atattgcccc gcatacgttg aaggtcgccg cgatgttctc aatccttacc 818881 cggttaaaag agccgaagcg gtcggatatt gatctggtca agaaaatgag actgtatgat 818941 ggggaaagtg tggaaggata taactctgtc gacgttgagg atatgaaaaa agaatataat 819001 gatgaaggca tgagcggaat tgatccgcgg tacgtgatca accggatttc ttcaacgatt 819061 atcagaaaaa atatggaatc gattaattct ctcgatgtcc ttcgctcctt aaaagaaggt 819121 cttgatcagc acccatcaat ttcaagcgag gacagggagc ggtatttgaa ttttatctct 819181 gccgcccgca aggaatatga cgatattgcg aaaaaggaag ttcaaaaagc gtttgtttat 819241 tcatatgaag aatcagcaaa aacacttatg gacaattacc tcgataacgt agaggcctat 819301 tgcaataaaa acaagcttcg tgatcctttg acaggagagg aaatgaaccc tgacgaaaag 819361 ctgatgagat ccatcgaaga gcagatcggc atttcggaaa acgccaaaaa agcgttccgc 819421 gaagaaattt taatccgcat ctcggcctat gcgagaaaag gcaagcggtt tgattacaat 819481 tcccatgaaa gactgcgtga agctattcag aaaaagctgt ttgctgatct gaaggatgtc 819541 gttaaaatta cgacctcaac aaaaacgccg gatgagcagc agctgaaaaa ggtaaatgaa 819601 gtcgtggccc gtttaattga tgagcacggc tacaactcga cgagcgccaa tgagctgctg 819661 aaatatgtcg gcagcctgct gaaccgataa gcaacgtgac ccgtccgaat agggcgggtt 819721 attttgtccc attttctaaa tagtttgtca attaaacgtg catatgtgca tatgatgaat 819781 ataaatcttt tcaaaagact tgtttcataa tctggcacaa gccggaatac gtatgtatca 819841 cgaccacaaa tggttaagga ggggaattca tgtcccaaaa tgacagcggc cattttttga 819901 tttctgagga aaactggtcc ctccatcgca aaggcttcga tgaccagcag cgccaccaga 819961 aaaaagtgca ggaagcgatc aaaaacaatc ttccggacct cgtaactgag gaaagcatta 820021 ttatgtctaa tggaaaagat gtagtgaaga tcccaatccg ttcacttgat gagtataaaa 820081 tccgttataa ctatgataaa aataaacatg tagggcaagg agacggcgag agccaggttg 820141 gagatgttgt ggcccgggat ggatcagaca aaaaacaagg gcctggaaaa gggcagggtg 820201 ccggtgatca ggcaggcgag gattattatg aagcggaagt ttcattaatg gatttagaag 820261 aagcgctttt taaagaatta gagcttccga atctccagca aaaagagcgg gacaatatca 820321 ttcatacaga tatcgagttt aatgatatcc gtaaaacagg gttaaccggt aatattgata 820381 agaaaagaac gatgatgtca gcctttaaac gaaacgcaat gtcaggaaaa ccgtcgttct 820441 acccaattta tccggaggac ctgaaatata agacgtggaa tgacatcaca aagcccgaat 820501 caaaagccgt cgttttagcc atgatggata caagcggcag tatgggggtt tgggaaaaat 820561 acatggccag aagcttcttt ttctggatga cccgtttttt gcggacaaaa tacgagactg 820621 tggaaattga atttattgcc catcatacag aagcaagagt ggtctcggag gaggattttt 820681 tctcaaaggg agaaagcggc ggaacaattt gttcttccgt atatcggaag tcgcttgagc 820741 ttattgatga aaagtacaat cccgcccgct ataacattta cccgtttcat ttttctgacg 820801 gtgacaacct gacatctgat aacgcgcgct gtgtgaagct ggtcaatgat attatgaaga 820861 aggccaatct gttttgctac ggcgaggtca atcagtacaa caggcattca acgttaatgt 820921 ctgcatataa aaatgtaaaa gatgagaaat ttaagtacta tattttaaaa cagaaatctg 820981 atgtttttca ggctctaaag aactttttca gaaatgaaga gtctggtgta agccatcaat 821041 tttcgtaatg aaaagcccat ttcagggctt ttttttattt aataaaagca agaaaacgct 821101 tgcgaaaaaa atacgggaga aaaagaaatt tttcctttga caaatcttct ttcatttatt 821161 aatattttat cttgtgaact attattgagg aatgaggtga aaaggagttg actgaatcag 821221 aacgtgcttt gctcactttt gaacagctct tcgatacgtc tcgggcgata tataaaaaac 821281 agaagaagat attggagatt gtgcttgagc cttttgatat tacagtcctt caatatttgc 821341 tgatgtttaa aattcatcaa agcggaagca ccccgctaag caagctggca atgtcgcttg 821401 atcttaagcc tgcttctgtg acgcggatga cagatattct gtataagcgc caattgatga 821461 atcgatatga cagtccggat gaccgccgta tcgtcatgat tcagttaacc gaagaggggg 821521 aagaactgat agaaaaagcc gctgtgcaat atgcaaaaat gggtgctggc ttgtaccaaa 821581 agcttgatac ctcccagctg cagtatttgc gcaaactagc cggaagttta acgaagcttg 821641 ctgaaggctg ttcagaaaaa agcggtaatt aaaaacttct cacatatttt caccagcttt 821701 ccgcaaaatg atagaggatg aaacgaaagg agaaaacaaa atgaacagag gacgtttaat 821761 tctgaccaac attatcggtt tgattgttgt tcttgcaatt atagctggag gtgcttacta 821821 ctattatcaa agcacaaact acgtaaaaac agatgaagca aaagtagcgg gcgatatggc 821881 tgctattact gctccagcag caggtaaagt atctgactgg gatctggacg aaggaaaaac 821941 agtgaaaaaa ggcgacacag ttgcaaaaat caaaggtgaa caaactgttg acgtaaaatc 822001 cattatggat ggcacaattg tgaaaaacga agtgaaaaac ggacaaaccg tacaagctgg 822061 tacaacaatt gcacaaacga ttgacatgga caacctatac atcacagcaa atattaaaga 822121 aacagatatt gcggatattg aagtaggaaa tagtgtagac gtagtagttg acggagaccc 822181 tgatactaca tttgacggta ctgtagaaga aattggttat gcgactaact caacttttga 822241 tatgcttcct tctacaaatt caagcggaaa ctacacaaaa gtaacacaaa aagttcctgt 822301 gaaaatttca atcaaaaacc catctgataa ggtgcttcct ggaatgaatg catctgttaa 822361 aatttctgag taaaacagat cagtcatcaa accatgaaag gaggttgtct tagatggcta 822421 caggcaaaga aaaaaatgca aaaaacccta tgtcattgct gattgtgcta atggcgggtt 822481 tatttttggc aattctaaac caaacactgc ttaatgttgc aatgccgcac ttaatgactg 822541 aatttggcgt aagtgcaacg acgattcagt ggctgacaac aggttacatg cttgttaacg 822601 gtgtattgat tccgttatct gctttcctga ttacacgatt tggccagcgg agtctctttc 822661 tcgtcgcgat gttttgtttt acgctcggta cgttagtctg cggtatcgca cctaacttct 822721 ctacaatgct gatcggccgt ttgattcagg ccgtgggcgg aggtatcttg cagccgctcg 822781 ttatgacaac cattctgtta attttcccgc ctgaaagcag ggggaaagga atggggattt 822841 tcgggctagc gatgatgttt gctccagcgg tcggcccgac tctttccggg tggattattg 822901 agcattatac atggcgcatt atgttttacg gacttgtgcc gatcggcgca attgttatca 822961 ttgtggcttt cttcatcttt aaaaatatgg tggagccgca aaaaatcaaa ctcgatactc 823021 ttggcgcaat cctctcgatt gtcggattcg cctccttatt atacggagtc agtgaagccg 823081 gatctgacgg ctggaccgac ccgattgtat tgtctacagt tattatcgga gccattgcaa 823141 ttgttgcttt tgttgttcag caattgcgtc atgatgatcc gatgcttgat ttcagagtgt 823201 ttaaatatga cattttctca ctctcgagtg tcattaatat cattattaca gtggcacttt 823261 acactggtat gttcctttta ccgatttatc tgcaaaacct ggtcggcttt acggcgcttc 823321 aatccggtct gcttctgctt ccgggtgcga tcgttatgct gattatgtca ccgatctcag 823381 gtattttgtt cgataaattc ggaccgagac cgcttgcgat tatcgggctt ctcgtgacag 823441 tggtaacaac gtatcaatac acgcaattga caattgatac accatataca cacatcatgc 823501 tgatctattc aattcgtgca tttggtatgt ctctcttaat gatgccagtc atgacagccg 823561 ggatgaacca gcttcctgcc cgtctgaaca gccacggaac ggcgatgagt aacacgcttc 823621 gccaaatcag cggatcaatc ggaacaagtt taattacgac gatttataca aaccggacga 823681 cattccatta ttcacaaatt gcagataaaa caagcacggc ggacccgaac ttcctccatg 823741 cgttccaaaa tgcagtttcg aatttaatgg tgaatatgaa tgtgtcttat gatacggcga 823801 aaacatatgt gtactcacat atttataaac acgcatcact cgattccaat gtcatgggga 823861 taaatgatgc ctttatgtgg gcaaccttat tctgtgtagc aggtttgatt ttaagtatct 823921 tcctgcgtga cgtcagaaaa gataaattgc gtaagaagaa aaaagaggag ctttcattac 823981 ttcctgctcc aaaagaagct aaggaatctt aatctgtaca gggaggtttc ctgaatgaaa 824041 atttatgtag tgtatgatag tgaaggcgaa catactaaag tgcttgcaga agcgattgct 824101 gaaggcgcga gagaaaacga cgcggctgaa gtgttcatcg accatgtaga tcaggctgat 824161 atccgcaagc ttaaagatat ggatgcgatt atttggggat gcccagggca tttcggaaca 824221 atcagctccg gtcttaaaac ttggatcgac agacttggct acttgtgggc tgaaggcgag 824281 ctgatcaaca aagtcggtgc tgtcttctgc acaacggcaa caacacacgg cggcttggaa 824341 atgacaatgc acaatttaat cacgccgatg ttccaccaag gcatgattgt tgtcggactg 824401 cctggcaacg tgcctgaaaa cgcactttat ggctcttatt acggagcagg tgtcacttgt 824461 ccggtagaca gtgatgagtt aatgtctgag gaaggtattc agcttggacg cgcgttggga 824521 agacgtgtca gccaagtcac aggaaaccta acagcaggac agtaaggaga ggttgaaatg 824581 gccattatta tagcaataat tgctgctgtc attgtcattg cggcccttat tacatttaac 824641 gtccgcaacg cctcacctgg acctgagaag caagaagcaa ccgatagaat cgcacctcca 824701 gaagaggaaa aaaacgaagc gcattaccct gctgaagcaa gggctgccga gcatacgcca 824761 tccgttgtca aaaacgattc tccaaaagag aagcgtgaca caatgggtga tgatatttac 824821 aggcaggcgc tgcaaaagtt taagcattct gatgaagttc atgcagaaga agaggtcact 824881 gaggaaagtg acaaaatgca ggaccgcagc tatcgtgatg cgctgctctc tatgaaaaat 824941 aagaaaaagt aatgaaaaag gcaaatccgt ttactcatgc gggtttgcct tttttgctgt 825001 ttccatcaat tatgttttta tcaaataaat ccatggaata tgttgtattc caccttgatc 825061 tagtgtacta tgttactcat acaccgagga ttttttccgg gaggtaaaga catgaattct 825121 tttttaggtt tattaaagaa agatatcaag ctttcaagaa tgtggctgct agtatggata 825181 tgcggaatca ttttcttatt gggaacaggc catattatag cttctcgcac gaaagaacct 825241 ctagtcattt ttggtttttt tgttgcagtt gctttttttc tgcttttctt atctcctgtt 825301 tttgtttttt atcaccttcg caaggaaggg aaatcacagc tttggctgta caatccaaat 825361 ggcggcttat ggctgttttc ttctaaattg gcagcatctt tgctctatca atttgtgatt 825421 cagttggcat taacagccta tggcatatgg atgtatcata tgctctctgt aaaaaatctg 825481 ctggagcatc aagttgatat aacgagtaca gtggctttgc tgaatatgta tgggcttatt 825541 tcttcgttag atatgtcagt aacagtcatt gtgttttgga ctgtttttca ctctctcaga 825601 aattggcgcg gaatgcggtg ggctgcgatg gttctgttgg tcgcaatgtg gttattcttc 825661 gatgaataca tcataagccc tttggttgaa tctcaaaagc atttctggcc tgtaacagtc 825721 tattgcaatt ttgatttcca cttccacaat gtttggagat tggaactaaa acctatccat 825781 ctgtctgtgc tagggtttcc tattgctata gtcatcacat tcttgctgct catcatggct 825841 tcaaaactgc ttgatcgtaa agtagaggtg taaatatgga caatcaattc caatcctcga 825901 aaccgattta tctgcagatc gctgatcaga tcttttatag gctggtcagg aaggagctgc 825961 tcccaggaga caagcttcct tcagtaagag aaatggcgat tcaaactaaa gtaaatccca 826021 atacaattca aagaacttac agtgagatgg aaaggctggg tattgtggag acaagaagag 826081 gtcaagggac gtttattgcg gaaaaagcag aaatcgtaga cgagctgaaa gacaagctga 826141 cacgagaggt gctggaaggc tttgtcaagc aaatgaaaga gctggggcta acgaaagaag 826201 aaatgttaga agggattaaa acattcacag agggaggcta aaatggaaat caagctagaa 826261 catgtatcaa aaaaatacgg ccgccatacg gccgtcaatg atgtgtcaat caccctatca 826321 tccggacgga tttatggcct gattggaccg aacggcagcg gcaagtcaac gaccctgaaa 826381 atgatggctg gccttctgtt tccgacttca ggatttgtaa aagttgatga agagcaggtt 826441 acgagagaaa tggtgcgtca aacggcttat cttactgagc ttgatatgtt ttatccgcat 826501 ttcactgtta aagatatggt gaatttttat cagtcgcagt ttcctgattt tcatacagaa 826561 caggtttata agctattgaa tgagatgcag ctgaatccgg aaaaaaagat caaaaagcta 826621 tcaaaaggaa atcggggcag gctgaaaatc gttcttgctt tagcgagacg ggcagacgtc 826681 atcttgcttg atgaaccttt ttccgggctt gatccgatgg tcagggattc catcgtaaac 826741 agccttgtgt cgtacattga ttttgagcag cagattgtcg tgatcgcgac acatgaaatt 826801 gatgaaattg agactttgtt agatgaagta atcatcctcg ccaatggaga aaaagttgcg 826861 cagcgtgaag tagaagatat tcgtgaacag gaaggcatgt ctgttttgca atggtttaaa 826921 tcaaaaatgg aagtttgcta gaaagaggag gaatatgatg aaaacagtgt tggaattgaa 826981 aaacgtgact aaaaacatca gaggccgaac gatcattgat gatctcagtt ttacgattcg 827041 tgaaggcgag gtattcggtt ttttaggacc aaacggagcg gggaaaacga caaccatccg 827101 gatgatggtg gggttaatga agctgtcgaa aggtgatgtc ctcatttgcg gccaatcaat 827161 tacgaaagaa tatgccaagg cgattaagca tatcggagcg atcgttgaga atcccgagct 827221 gtataaattt ttgagcggat ataaaaatct ccagcaattc gcaaggatgg tcaagggtgt 827281 cacgaaggaa aaaattgatg aagttgttga actggtcggt ttaacagaca gaatccacga 827341 caaggtgaaa acatattctc tggggatgag acagcgtctt ggcttggcac aatgccttct 827401 gcacgatccg aaagtgctga ttttggatga accgacaaac ggccttgatc cggcggggat 827461 cagagaaatc agagatcatt taaagaagct gacccgagaa agaggaatgg ctgtcatcgt 827521 ttcaagccac ctgctgtcag aaatggaact gatgtgtgat cgaattgcga ttctgcaaaa 827581 aggaaagctg atcgatattc aaaatgtaaa agatgaaaac attgatgaga atgatacata 827641 tttcttccag gttgagcagc cgagtgaagc cgctactgtt ttaaatcagt acgatttgct 827701 gagtaagaca aatggtgtag aaatcaaact ggctaaagag gaagtccctg cggttattga 827761 attgctggtg atgcagcaaa tccgtattta tgaggtcaag gtcataacaa aatcattaga 827821 ggaccgtttc ttagaaatga caggtgaaac aaaagaggag gttcagcatg cttaatttga 827881 tttataatga gtggctcaaa attttcagcc gtgccggaac atgggtgatg atcggaattc 827941 tggggctgac aatggttgga tttgcatttt tggcgaatca tttttctgcc ggtgaatcaa 828001 attcccattg gaaacaagag cttcaagcac aaaacgccga attaaagaaa gaaatcaaag 828061 aagatccttc actgaaagat gggtataaag aaacaatcac actcaatgac tatcgcatcg 828121 agcataatat ccctagtgac acgggctata cggtatggtc ttatgtaacg gattcagcaa 828181 actttaccat ccttaccggt ctgtttacta ttatcatcgc ggccggaatt gtcgcgaacg 828241 aatttaattg gggaacgatt aagctattaa tgattcggcc gctcagtcgt tttcaaattt 828301 tgatgtccaa atatattaca gttctcctgt ttgggctcct gttgctgttg attttattta 828361 tcggttctac tttattaggg ttgatcttct tcggaacggg tggtgaaacc gccgcgaata 828421 ttcatttaat ctataaggat ggccatgtca ttgagcaaaa catgatgggg catttggcta 828481 caacgtatct ttctgaatcc gtctcggctt taatggtggc gacgatggcg tttatgctgt 828541 ctgcggtatt cagaaacagc tctcttgcgg ttggtttttc catcttcttg ttggttgccg 828601 gtacgactgc aactgcattt attgcagcga aatttgactg ggcaaagtat atattgtttg 828661 ctaatgtcga cttgactcag tatgtggatg gcacaccgtt aataaaaggg atgactatga 828721 cgttttctct cgtcatgctg gcgatctact ttatcatctt cctgttgctt gctttcggaa 828781 tcttcatgaa gcgggatatt gcaaactaat aaaaaaagct gttttgctta tgcaaaacag 828841 cttttttgtc aaaataaaaa ctgcaggttt gcacctgcag tttttcatat caatttatgc 828901 ttacgcttct ttagtaacgt tagcagcttg tggtccgcgg tttccttcaa cgatttcaaa 828961 agaaacagct tggccttctt ctaaagtttt gaagccttcg ccttgaatag cagagaaatg 829021 aacgaataca tcgtcttgac cttctacttc gatgaatccg aaaccttttt cagagttgaa 829081 ccattttact ttaccttcta acatgaaatt tcctcctaaa gcgatcataa cgcttaaatt 829141 cactattctt gctcttaaca aactttcaag acgaaaactc ttacaaaact ttcttcttaa 829201 agatagttcg aacaaaaata attaccttta ctctaccagt aatcttcaga aaaaacaact 829261 gcttattgaa atttttttcg gaaaatacca tatttatttt tcaatttgat atttatttac 829321 ggaaattcat ctgttttctc gatatgtgat catacgtttg ccttagtatt ccttcatttt 829381 gggaagataa gtaataggaa ttgacaacct tattggatat gagtaaggta aaagttaatc 829441 aatattacaa atgacaacgt ttatcaacta agagagcgta tgatttttat gtctgatatt 829501 gcttgcatgc tctaatacat agataggagt atggtcacaa tgaaaaagtg gcttatatgc 829561 agtttcgtcc ttgttcttct cgtttcattt actgcatgtt caccgtctgc agaacatgaa 829621 tcgataaaaa tcgggattgc tgagtctgac ggggcaatat ggaactatat tgctcaaaag 829681 gctgaagagg cagggctgga tattcagctg atcccttttt ctgattatgc ggagtctgat 829741 atcgcacttg ctaacaaaga aattgatgcc aacgcctttc aaaccatttc atattttcag 829801 tcgttcactg aaaaatacaa acttaatttg gcaccgctcg ggacgacata cataacgccc 829861 atgggcattt attcaaaacg atatgaacga atccgagata tatcgcgggg agctgtcgtt 829921 tctgttccgg ataaagcgtt cgattttggc agggcgctta cggtgctcca ggaagcgggt 829981 ttgctaacgc tgaaaaacgg atttaacgga acaggttcag ttgatatgat taaagataat 830041 ccgagacacc tgaaattaaa agctgtccgg caacaggatg cagtgagcgg tgccgacgtg 830101 tttgtcatga aaccatcaga agcaaaaaaa gcgggcttga acccgaaaaa gcatacgcta 830161 aagagcggcg gactcatgtc tgaggaagag atgaatttga ttgttgtcag agcggaggat 830221 caagatcggg aagcgctgca aaccattctt gagctttatc aagctgatga tacagcggca 830281 tttatagaaa aagaatatca gggagatctt gtcccggctt ttctgccttt gaaacgtctt 830341 tcagattgga agaatgaatt cgaacattga attcattctt ttttttctga aaaacacact 830401 ctgttccgtc ccgtttcttt cgctttgtaa agcatttgat cggcaagaat gggcaaggat 830461 cctggctgtt ccgtattatt ggggtaatga gcggccccta gtgatatcgt aactgaaagc 830521 tcgtcgccgt ttgttaatac aatcggtgca tcacttacag tgctcctgat ccgttcagcg 830581 atccgggctg ctttatcaag agaacagttc ggcaggagca cggcaaattc ttcaccgccg 830641 atccgagcgg caggatcagt atttcggatg gtctgcttca gacgtaaccc tagctctttg 830701 agcacctgat ctccttcatg atggccatat tggtcattga tggtcttaaa atgatcgata 830761 tccatataaa tcagtgcaaa ttgaaaatgc ggggtatcgg ccgcctgctg atacagagct 830821 tttgtggttt cttcaaattt tcttcggtta tacacgcctg ttaaaaagtc aaagtgcgcc 830881 tgaaacttat attgtttaaa aagaagatgt gcatttgttt catgatcaat aatatataaa 830941 ctgagcatgc cgcccgctat tgatatgatc caaaaataca aatgaagttc gtatgaatgt 831001 aaatctataa gaaaataaaa ggaaaaggag atcaagctat ttgtgattat taaaagatag 831061 aaagcatgtt ttagttgaac tttttttctt ctagaaacaa tgagtgacgg aatggcagcg 831121 atacaaatga taataaccga gtatagtgca gatgtgttca tcgtaatcag caagcggcct 831181 gcagtgatca tggccagggc cgttgccgtt gaaacccagc ctccataaag agcggcaatc 831241 ataataggga tatttcgaag atcaataatt gaatgctgat aggtaaatcc aaaaaccatc 831301 agaataaccc cgagcaaacc gcaggccagt cctttaacag cttgaaagga tatgctgtct 831361 tttttatgta ctagcctttc tttaaacagg tgggtgaaga gataattaaa tgtgattaaa 831421 atggtcaaat ttacaaacag ttctttcagc aaatattatc acccttatat aaggtactaa 831481 agatggaagg gaaagaaaag aacaaaaaag gcattatata aggttttttt acttgaattg 831541 ataagttaaa ataattcgca cttgacccat cggaattagt gtaatatagt aaatgagaaa 831601 atttgaaggg agagtttacc tgctttggag actttactgg ttgtattaca tgtatttatt 831661 ttatttttac ttatcttagg gctctttgtt atgcagaaaa aacatgtttc cttctctaaa 831721 cgtgtattta ctgcgctggg gctggggatt gtattcggat ttgcgcttca gctgatttac 831781 ggcccgactt caaatatagt cattcaaaca gccgactggt ttaatattgc cgggggcgga 831841 tatgtcaaat tgcttcagat ggttgtcatg ccgctcgtct ttatttcgat tctcggcgcc 831901 tttacaaagc tgaagctgac aaaaaatctt gggaaaatca gcggtttgat tatcgggatt 831961 ttagtagcaa caacagcagt tgctgcagct gtcggtatcg cgtccgcgct ttcatttgat 832021 ctgcaggcga ttcaggttga ccaaggaagt acagagcttt cacggggaca ggagcttcag 832081 cagaaatcag aggatatgac agcgaaaacg ctgccgcagc agattgttga actgctgcct 832141 ggaaacccgt ttttagattt tacgggagct agaccgactt caacgatcgc tgtcgttatt 832201 tttgccgctt tccttggagt ggcattcctc ggcgtaaaac acaaacagcc ggaacaggca 832261 gaaacattta aaaaactggt tgatgccgtt tatgccattg tcatgcgtgt tgtcacactc 832321 attttgagac tgacgcctta tggggtgctg gccatcatga caaaaacaat tgcaacgagt 832381 gatcttgaca gcattctaaa actgggcatg ttcgtgattg catcatatgc cgcgttaatc 832441 actatgttta tcattcattt gctgctgctg acgttcagcg gcttgaatcc ggtgatttat 832501 ttgaaaaaag cggtgcctgt acttgtattt gcatttacgt caaggtctag cgcaggtgct 832561 ttaccgctga atattaaaac acagagaagc atgggtgtac cggagggaat cgcaaacttt 832621 gccggttcgt tcggtctttc gatcggccaa aatggatgtg ccggcattta tcctgcgatg 832681 ctggcgatga tgattgctcc gactgtcggc caaaatccat ttgacccggt gtttattatc 832741 actgttatcg cagtcgttgc catcagctcc ttcggggttg ccggagtcgg cggcggagcg 832801 acattcgcgg cgcttcttgt tttatcatca ttaaacatgc ctgtcgcgct cgccggtttg 832861 ttaatctcaa ttgaaccgtt aatcgacatg gggcgtactg ctttgaatgt cagcggaagc 832921 atgacatccg gtcttattac aagtaaggtc acaaaagaaa ttgatcaagg ggcatttcat 832981 gatcaatcca gagtgattga agctgaagaa gcgtaacata tgaaaacgtg taatccaaga 833041 ggattacacg tttttttaac ggccaggctc taagtcctcc agcatttcca tcatcgtgtt 833101 gtcgtccatg acattcattg cgttttgttc aaaatgaatg ggttcagcat aatgcggctg 833161 tctttttttc gcggctgtct cagtttgcct agtttgagac tgtgtatgct gatgctgtgg 833221 ttgctgctgt ccagcgtgct ggtgctgacg gccattttgc cgctggcttt gatgctgcga 833281 acggtcctgg ttatcaccgc tgcttccgct gcttccgcta aatgcttgtt tgaccatgtt 833341 tcctacatta gaagcatcaa acgtgttatt ttctgaattt cgtctgttca tttgtcctgt 833401 gataaacccg ctgattcttt ggcggatctg aggtgataat gcagtaataa gcatagttga 833461 tcctatgatc aatgctgcgg ggctgattcc tcttcgctgg ttgaacaaca tgatccctcc 833521 tttgcagtgt attcatattt tccccctcgt tagacaaatt aaccgttata tttcccggga 833581 aagcatttcc tccagatttg catgcataat taaagccagt tagaaaaacc tataagtaaa 833641 gtgataaagg aggaattcac atgtttggaa aaaaacaagt ccttgcgtct gtgcttctta 833701 tccctttgct tatgactggc tgcggtgtag ccgaccaagg tgagggcaga cgtgataata 833761 atgatgtaag aaacgtaaat tatcgaaatc cggccaatga cgatatgcgg aatgtaaaca 833821 atcgggataa cgttgacaac aatgttaatg ataatgtcaa taacaatcgt gtaaatgacg 833881 ataataacaa cgaccgaaaa cttgaggttg ctgatgaagc agctgataaa gtaacagacc 833941 taaaagaagt aaagcatgcc gatatcattg tggctggaaa tcaagcctac gttgcagtcg 834001 ttttaaccaa tggaaataaa ggtgcagtag aaaacaatct gaagaaaaaa atagccaaaa 834061 aggtaagatc tactgacaaa aacattgata atgtttacgt ttcagctaac cctgattttg 834121 tagagcgtat gcaaggatat ggaaagcgta ttcaaaatgg tgacccaatc gccggattat 834181 ttgatgaatt tacacaaact gtacagcgtg tattccctaa cgctgaataa atgaaagaag 834241 ccgcacaatt tgtgcggctt tttctttgcg ttaatgacac actgcgaact caggctgcat 834301 agagtaaaaa taaaaaggta caagacggac cggctcaggg agggagacgt ttgcgggatg 834361 gcataggaaa gcgtgcggca tccgctctat tcctgtgcgg agtccttgtg atgctggctg 834421 taagctcagc catcgtatca agcgcgatgt atatcctgtc ttttccaggt caggcatctg 834481 gaataacaaa agaacaagtg acgaagcaca tgaagaaaga gtcattcaaa caggccgata 834541 tttattacac ttctaaggaa aagtccttac tgccattgac gaaagaaacg cttgaatatg 834601 cggtcagtat taatcagatt atgattggat attcgaatca aaagcctatt gacattattt 834661 tttttcctaa tgaaaaacag atggaggctt actccggttt attggatgta gttggttttt 834721 attctgaacg ggagcagctg atcggattgt tgcctgaaga gaaaaagaaa ctgttagaag 834781 gggacgaggt agcggtttat ttgtaccaga gattgttgat tcatgaatac tcgcaccatg 834841 cgtttcacca gaaattgaag gagcttgaga cggatcccga tgagtttccg ttatggtttc 834901 atgaagggtt aagcgagtgg attgcgaact atgaattgct catagatccg atcacgtttt 834961 ctgtcgtgcc ctttgaccgt ttgcagactg atcgagactg gcaggaagct agagccgaat 835021 atgacactga tgtctatttg caaagctttt atatgatcga tgagctgacg gacaaatacg 835081 ggaaagacat tatttcagaa atgattaagg aaacggcaaa aaaaggggac tttgaaaaag 835141 ggtttaaatc agcaacaaag gaaagtcttg atcaatttga aaaagatttt aagaaaaaat 835201 ttgaaaaaaa cagtgcggca ttggatagta tctatccaat gcctttgtta ttagtgaagt 835261 ccttgctgac ccattccgcc ttgtgtcgga ggcatttgtc cttgggcagg ggcgaatgaa 835321 tttcgcagct gttccatatc ctgcgcatca agctgaggaa cctggtaata gccgtgtttg 835381 ttttggtata ggaaaatttc aaatgccatt tcaacatact cctgaatttg cgcagacagt 835441 acgcgtctta cggccggatt tgtcatttcc agagaagcca tcgtcagcat agaagcttgt 835501 gctttaatcg cgcaaagcat ttgtcggctg atgatgctgt catcaatatc attcatggat 835561 tgaacaggtt ttttaggctg tgacggctgc atgccgtaaa cagtctggtt gtcttccttc 835621 atcatataag ttgctgtttt ttgtgaaggt tcgcttcctg ttttgaagca ttctgcagtt 835681 atattgtatt gagatgtgat gaattgatgt tgacgatcaa ggatgtttag taattcttga 835741 tccttacaga attgtctcag catcataaac tgatcaagca cagtaagtgt tccggaaagc 835801 acctcatgca tatcaaacat ttcatgtccg ccgtggtttt tatgcggttt gccaggaata 835861 cctttgttca tttgggattg ctgctgctga ttgaactgat ccaaaccgaa ttcctccttt 835921 tttttcagat cagctgtatt ttgtgtcagt ctgccgtgta ttatgcagaa gcctgaaagg 835981 aattatatgc tgtctgtcga aatgataagc agacaaaatc gttgtcatta tgtgtataag 836041 ggaggaaata tgatgaggcg tattctgcat attgtgttga tcacggcatt aatgttctta 836101 aatgtaatgt acacgttcga agctgtaaag gcagctgaac cgcaacagcc tatatcgatt 836161 gagaaggcaa tacagcaaaa agaaggacag gcacttgtcg aaggatatgc agtcggccag 836221 gctgtttccc cgcagcatta taaactgaca agcccttttt caaatgatta taatgttgcg 836281 ctggcagacc gtaaaaacaa aacatcgccc gaacacatcc ttcctgtgca aatcccctcc 836341 gccttcagaa gccaatttgg gctgcaaacc aatccgcttc ttcttgggaa aaagataacg 836401 gttcaaggaa agcttgaaaa ttactttaac acgacaggac ttaaaaacgt tcagtcgatg 836461 aacgtaaccg atgacacaaa aactccgccg gctgaacagc aagtgaccat aaatgaagca 836521 cggggaaggc tgaatgaaga agtaacgata aaagggatca ttacagctga tcaaaacgca 836581 atcggaggcg ggaagctgtc gacctttttg caagatgaaa ccggaggcat taacatttat 836641 tcgccatccc ctgaacaatt tcccgaatta aaagagggta tggatgtcac ggtgacaggg 836701 aaaatcacgt cttaccaggg gctgaaagaa atcgttccaa actcatcagg catcaaaatc 836761 aaccagtcaa atcaatccct ccccgccccc aaacacttaa caatcaatga acttattaac 836821 ggcagcctag gtgatcagta tgaaggacgc cttgtgaaac taaccgcttt tgtttcctca 836881 attccaagtt ctcctgccgg cggcggttac aatgtaacaa tgattgatga cgaccatcat 836941 gcaatgacgc tccgggttat gaatgaaaca ggggtgataa acgagcttga tgagggcaaa 837001 tggtatgaat ttaccggtgt gttaagcaga taccaaacct ttcagctgct tccgcgaaaa 837061 tcggctgacc tgaagctgct tgaagagcag cccgcacctc cgtctgcaga gggagaatat 837121 gaagggattg ttgaccgggt agttgacggc gataccattc atcttaaatc tccggtgctt 837181 ggaacgacaa aaatccggtt tgtaaatgta gatgcacccg aaacatatca cacaccaaaa 837241 aatgacgcag atgaaaatca attaagattt ggcaaaaaag catctgacta tctaaaaacg 837301 gttctgtccc cgggtgataa aattactgtc aaggtcggga gtgaagccaa ggacagctat 837361 ggcagattgc tcggacaagt cataaccgaa tcaggttcaa acgtgaactt agagcttgta 837421 aaaaacggct atgctccgac gtattttatt tggccggttg acaatgaaga ggattatcag 837481 caatttcagg ccgcagtagc cgctgcaaaa aaagatcaaa aaggaatttg gaatgaaaac 837541 gatcccctca tggaaatgcc gtttgaattc agagccagag agcaagggaa aggcctgaca 837601 agatatgtgg gggactcgtc gaataaaaca tatgtgcagc cagctgactg gaagaagata 837661 gctgtggaaa acagaatttt cttcgcctca gcaagtgaag cggagagcgc gggatataaa 837721 aaaaggcaaa cggcacctca agaacatgtg ccgcttagaa ttctcagcat gaatgatttg 837781 catggcaaaa tcgatcagca atatgagctt gatcttgatg gaaatggaac tgtagacggc 837841 acgtttggac gcatggatta tgccgccgca tatttaaaag aaaaaaaggc tgaaaagaaa 837901 aactcgctga ttgtgcacgc gggagatatg atcggcggaa gctctccagt ttcctctctt 837961 cttcaggatg aaccgactgt agaactgatg gaggacatcg gatttgatgt cggaaccgtg 838021 ggaaaccacg aatttgatga aggcacggat gaacttctga ggatcttaaa tggcggtgat 838081 catccgaaag gcacaagcgg atatgatgga cagaactttc cccttgtatg tgccaattgt 838141 aaaatgaaat caactggaga gccctttttg ccggcttacg acatcattaa tgtggagggc 838201 gtacccgttg cttttatcgg agttgtcaca cagtcggcag ctggcatggt tatgcctgaa 838261 ggaataaaaa atatcgagtt tacagatgaa gcaacagcgg tgaataaggc ggccgaagag 838321 ctcaagaaaa aaggcgtgaa ggccatcgcg gttctcgcac atatgtcagc tgaacaaaac 838381 ggcaacgcca ttaccggtga gtctgctgat cttgcaaaca aaacagattc tgaaattgac 838441 gtgatttttg ccgcgcataa tcatcaggtt gttaacggtg aagtgaatgg aaaactgatt 838501 gttcaagcgt ttgaatatgg aaaagcgata ggtgtcgttg atgtagagat cgataaaacg 838561 acaaaagaca ttgtcaaaaa gtccgcggaa atcgtatatg ttgatcaaag taaaatcgaa 838621 ccggatgtca gcgcgtcagc cattttaaag aaatacgaaa caattgcgga accgattatc 838681 agcgaggtag tcggcgaagc cgctgttgat atggaagggg ggtattcaaa tgacggcgat 838741 acacctcttg gaaacctgat tgcggatggt atgagagctg ccatgaaaac ggattttgcc 838801 cttatgaatg gcggcggcat acgtgaagcg ctgaagaagg gtccaattac gtggggagat 838861 ctttacaata ttcagccgtt tggaaatgtg ttaacgaagc ttgagattaa aggaaaagat 838921 ttaagagaga ttatcaatgc gcaaatctcg ccggtttttg ggcctgacta cagcatcagc 838981 gggtttacgt atacgtggga taaagaaacc ggaaaagcag ttgatatgaa aatggcagat 839041 ggcaccgaga tccagcccga tgccacatat acattgaccg tcaacaactt tatggcgacg 839101 gcgacaggag ccaaatatca gccaatcgga ctgctgggaa aaaatccggt gacagggcct 839161 gaggatttgg aagcgacagt tgagtacgtg aagagttttg atgagccaat tgcgtataca 839221 aaagagggaa gaattaagct tgctgaagcc agtgatattg aagaccctgt aacagaagac 839281 ccgataacgg aagagcctgg agatgatccg gggacggagg atccgattaa agaggatcca 839341 aggccaggtg aagatttgcc tgatataaaa gaaactccgg gaacagcacc ggttcatcag 839401 cttccgcctt cagccatttc gagattcaat gaaataccaa tcaacaacac aaaaaccgct 839461 gatactgcta atagcatcag cacattgccg ttacaaaccg agactgcgga aagcgggtct 839521 gatcatcagc ttccggatac gtcagcgggc tactataact ttatggtaat cggtgcggcg 839581 gtgacattgt caggaactta tctatatgtc agaagaaaaa ggagcgcctc cagaacgtga 839641 aaaaagttat tccactattc atcattgctg ccggcctagt gatcgcaggc tatggaggct 839701 ttaaattgat cgatacgaat acgaaaacgg aacagacatt aaaagaagca aagctggcgg 839761 ctaaaaagcc gcaggaagct tcggggacga aaaatagcac agatcaagca aagaacaaag 839821 catcatttaa gcctgagacc ggccaagcga gcggcatttt agaaataccg aaaatcaatg 839881 cagagcttcc gatcgtggag ggcaccgatg ctgatgattt agaaaaaggt gtcgggcatt 839941 acaaggacag ctattatcct gatgaaaacg gacaaattgt gctgtcaggg catcgggata 840001 ccgtgtttcg ccggacggga gagctggaaa agggggatca gctccgtctt ctcctgtcat 840061 atggagaatt cacatatgaa attgtaaaaa caaaaattgt cgataaggat gacacatcta 840121 ttatcacgct ccagcatgaa aaggaagagc tgattctgac gacctgctat ccgttttcat 840181 acgtcggaaa tgccccgaag cgctatatta tatatggaaa acgagtgact taaaaagccg 840241 aggcagtgcc tgcggctttt cttcatgaaa aatatgtgcg gcaaaggttt ttcatatcag 840301 cagggaaagg ggcttcagca actatgagct cgtctgttat cgggtgaacc gcttgtactt 840361 tattggcgtg cagtgcctgc ctgtttagca gcttgctccc gcctccgtaa agcgagtctc 840421 ctgtcaacgg atggccgagg ctcgccagat gaacacggat ttggtgtgtt ctgcctgttt 840481 ccagctctaa ttcaacgagc gacagccgtt ctttcgcatt gctggccatt accttgaaat 840541 gagtgacggc tgtttgcccg cctggtgaaa cccggcgtct tgtcgggtgt gagcggtctc 840601 tgccgatcgg tgaattaatt gtcccttttt tcgtccgtag cttaccttca gcgatagcgg 840661 tatacgtacg cttcagcgtc tttttctcta actgctggtc taagatggcg tgtgccaaac 840721 gatgcttggc aaaaacgata gcgccagatg tatcctgatc aagacgatgg acgtggcgca 840781 ccttacatgt ttcgccattt atctgataat gatacgcgat caaattagcc agtgtgccgg 840841 tttgcccatc ctcattcgga tgcgtcgcga tgccagcggg tttattgatg atgagcatat 840901 gattgtcctc aaataaaata tcaagctcgc catactccgg aatgaccgaa gatgcttcac 840961 tttcctgaag atcaatgaac acgcggtctc ccttttttac aatcatattg tttaagacgg 841021 attcgtgatt gacctttatc tgttgatggg acatccagtc ttgtatcact ggtttagaag 841081 ctttgagcgc tgttttgagt acggaaaaca gccattggcc gtcctgtttt tcattgatga 841141 ggatctcaag ccctctgcct ttttggttca tgttaaatgg ctccttttcg aagcggaagg 841201 ctgctgtttc tcataggaaa cacttacctt agctttcgcg tttttttctg tgctattctt 841261 gagtaagact taggatattc gatggcaaga aaggtgattg acgtgagaat tgtgaacgca 841321 gcaactgcag aacaggagag ctttatcaag gagctgtcta tggagctgat ccatgatgta 841381 tttcctcttt atttctccga actggacatt cagcgcttta aaaagaaagg cgttctgtct 841441 ttaaataacc attattacca aggaacatta aaagaagcat ttcaaattat ggcttgtctg 841501 caaatgatac atattatcct gaccaagcct tcgccgcact ctgatttgag tgatcaggcg 841561 atttttgaaa aaaacagcaa gatgctgaat gattttggga tttattttcc gtttgctttt 841621 tctgactttc aaaagaagac taacaaagcc tttttcggtc aaagaaggct gatataatca 841681 tgcggcaagg gcttttctat ttttagaaaa gctctttttg tatcagagaa atcatatcat 841741 aaaacctttc ctctaactcc ctttttaaac ggctcgtgtc tgaacatact aatgattgaa 841801 aggggtgctg acaatgagtt cagttaaaga tacaatgaca acgcaggtgg caaccgtttc 841861 tccgaatcaa acgattcagg aagcggcttc tctaatgaaa cagcataacg tcggggcgat 841921 ccccgttgta gagcaaggtg ttttaaaagg aatgctgact gaccgtgaca ttgcattaag 841981 aactacagct cagggccgtg atggccagac acccgtttca gaagtgatgt caacagaact 842041 cgtatcagga aaccctaata tgagtctgga agacgcgtcg cagctgatgg cccagcacca 842101 aatccgccgc cttcctattg tagatcaaaa caatctagtc gggatcgttg cgcttggaga 842161 cctggcagtc aatcagatgt cgaacgagtc tgcgggatca gcgctgacaa acatttctca 842221 ccaaaacatt cattaataag aaagagcttg cagtgtgcag gctctttctt cacataaaac 842281 cttacttttt gaaagcagac ttgtttcggg gtatagtgag tgtatacata tgtctcaatt 842341 cgtactaaag gagttgtacc cagtgattaa agcgttaatt tttgattttg acgggcttat 842401 tctagataca gaaacacacg aatatgaggt tcttcaggaa atatttgaag agcacggctc 842461 agtgctgccg ctatctgtct ggggaaaggt catcggaact gctgcgggtt tccggccttt 842521 tgaatattta gaagagcaga tcgggaaaaa gctgaaccat gaagagctca cacaattgag 842581 aagagagcgg tttgccaaac gcatggaatc agaaaaagcg agacctggtg tcgaagcgta 842641 tttgaatgcg gcaaaggatt taggcttaaa aataggcctt gcctccagct ctgattataa 842701 atgggtgtcc ggccatttga agcaaatcgg cctgtttgat gattttgaag ttattcaaac 842761 ggcggatgat gtggaagagg tgaagccgaa tcctgaactc tatttattgg cggcaaagaa 842821 cctgggggta tcgccagcgg aatgtctcgc gtttgaggat tctgtcaatg gttcgattgc 842881 tgcgaaacgt gcaggcatga agtgtgtcat tgtcccgaat aaagtaacgg gtaccttgat 842941 gtttgaagac tatgatcaca ggcttgaatc aatggcggag atggagctcg ccctattgct 843001 tgatcatctg aactcacaaa actagaaagg agcgagtagg ttgtctgaga aattagattt 843061 gacccggttt gaaaagaaaa tggttatccg caatatcgaa gagaaagaca tcgacaagat 843121 tatcgatctt caaaaggact gctttccagg aatggagcct tggaagcggg agcatttaat 843181 cagccatttg gagcattttc cggaaggaca gttttgtgca gaattcgaag gtgaaattat 843241 cggttcgtgc tcaagtctcc tgattaactt tgatgaatat gatgaccgcc atacgtggca 843301 ggacattaca gatgacggtt atatcaccaa ccataatcct gacggcttga atatgtacgg 843361 aattgaagtc atggtgcacc cgaaatacag acgaatgaag atcggccacc gtttgtacga 843421 ggcgagaaag gacttagcca gacgcttaaa cctgaaaagc atcatcatag gcggacggat 843481 tccaaactat cacaaatatg cagaggaaat gacagcgaga gagtatgttg aacaggtgac 843541 acgccaccaa atttacgatc cggttctttc ttttcagctg atgaacggct ttacccttat 843601 gcgaattaac ccgaactatc tcccggatga tacagcttcg atcaagtatg cgacgctgat 843661 ggaatggaat aatgtcgatt atctaccgca gcagacaaaa cgctattata aatcggcgtt 843721 ccctgttaga atttgtgtga tccaatacga aatgaagaaa atttattcct ttgaggaatt 843781 tgcgaatcaa gtagaatact atgtcgatgt tgcttccgac gcaagatctg attttgcggt 843841 gttcccggaa attttcacaa cccagctgat gtccttcctt gaggaacggt caccgagctt 843901 ggcggtgcag agaattaccg agtatacaga agattacatc agcctgttta ctgacttggc 843961 tgtgaagtat aacgtcaaca ttatcggcgg atctcatttc gtcgaagagg aaggcaagat 844021 ctataatatc gcttacctgt tcagacggga cggaacgatc gagaagcaat acaaactcca 844081 tattacgccg aatgaacgca aatggtgggg gatcagcgca ggagaccaag ttcgcgtgtt 844141 tgatacggac tgcgggaaaa tcgcgatcca gatctgttat gacattgaat ttcctgagct 844201 tgcccggatt gcggctgata aaggagccaa aatcatcttt acgccatttt gtacagaaga 844261 ccgtcaaggc tatctgcgtg tcagatactg ttcgcaggct agagcggttg aaaatcaaat 844321 ttatacggtt atctctggaa cggtcggaaa ccttccgcaa acggaaaaca tggatatcca 844381 atacgcccag tcaggcatct ttgccccgtc tgattttgaa ttcgcccgag acggcattgt 844441 cggcgaaaca aacccgaata ttgaaatggt cgtcatcggc gatgttgacc tggaaattct 844501 cagaagacag cgccaaaacg gtacagtgcg ccagctaaaa gacagacgac gtgatattta 844561 tcatattcaa tataaaaaat aattcccaaa aaacccgcct gaattggcgg gtttttttaa 844621 acaaaagcgg aattgtttag gtgctttctt taaaataaaa gtaaattgta tagtggatgt 844681 gccttatgga gtttctgtat tttcgccatt tcctatatca tacagaaaac ggctaggctt 844741 cacattgcta ttgcaatggc tgtccaagtt gtttcgagtg cgacctttat cagtacgatg 844801 ctgagcattg tcactttgcc tgttttgctt tggaagctgc atcctctttc ttcttgagaa 844861 aggggatgtt ttattattta cgcggtttat tgactctgac ccggtctggc tttatattga 844921 aggcagggaa atcatcacca agacatcaca taaagagaag gtctgtttca attgaattgg 844981 cattataggg aacgctaatg aaatggagat gatggggatg gaaaacattc agcaaaatca 845041 gggattaaag caaaaagatg agcaatttgt gtggcatgcc atgaagggag cgcatcaagc 845101 ggacagcctg atagcccaga aggccgaagg ggcctgggta accgacacag acggacgccg 845161 ctatttggat gcgatgtccg gtttgtggtg cgtcaacatt ggttacggca gaaaggagct 845221 tgcggaggct gcctatgagc aactaaagga gctgccttac tacccgttaa cgcaaagtca 845281 cgcacccgca attcaactgg cggaaaagct gaatgaatgg cttggcggcg attatgttat 845341 ttttttttcc aacagcggat cggaagcaaa cgaaactgct tttaaaattg cccgccagta 845401 ccatctgcaa aacggcgacc acagccgtta taaattcatc tcaagatatc gggcatacca 845461 cggcaataca ttgggagcgc tctcagctac cggacaggcg cagcggaaat ataaatacga 845521 gcctttgagc caagggttcc tgcatgcagc tccgccagat atataccgga atcctgatga 845581 tgcagacacg cttgaaagcg caaatgaaat cgaccgcatc atgacatggg aattaagcga 845641 aacgattgcc ggggtcatta tggagcccat cattacaggc ggaggcatcc taatgccgcc 845701 ggacggatat atgaagaagg tggaggacat ttgccggcgc cacggagccc ttttgatttg 845761 cgatgaagtg atctgcgggt ttggacggac aggtgagccg ttcgggttta tgcactacgg 845821 tgtgaagcct gatatcatta cgatggcaaa gggaatcaca agcgcgtatc tgccattgtc 845881 agcgactgct gtgaaacggg acattttcga agcgtatcag ggggaagctc cttatgaccg 845941 tttccgccac gtgaacacgt tcggcggaag cccggctgcc tgtgctttgg cgttgaaaaa 846001 cctgcaaatt atggaggacg aacagctgat tcagcgatcc cgtgatcttg gagcaaagct 846061 tttaggtgag cttcaagctc tgagagaaca cccggcagtc ggggatgtta gaggaaaagg 846121 gctgctgatc ggaatcgaac tcgtcaaaga caaattgact aaagagccgg ctgatgccgc 846181 caaagtaaac caagtggttg cggcgtgcaa agaaaaaggg ctgatcatcg gcaaaaacgg 846241 cgatacagtc gccggctaca acaatgtcat ccagcttgcg ccgccatttt gcctgacaga 846301 agaggacctt tcctttatcg tgaaaacggt gaaagaaagc tttcaaacga tataatataa 846361 aagtgaatta ttaaaggagc acatgatgag ttttcacaac cagccgatct taccggctat 846421 tcgcaatatg aagcaatttg atgagttttt gaacagttca ttctcttacg gtgttattct 846481 tgatattcat ctcggccagc tgaagggcgt gatcaaagaa gcgcaaaagc acggaaagaa 846541 catgatggtg cacgtcgatc tcattcaagg gattaagcat gacgaatacg gtgcggaatt 846601 tatatgtcag gatatcaagc ccgctgggat tatttccaca agatcgaatg tgattgccaa 846661 agcgaagcag aagaaaattt atgccattca gcgcctgttt ttgcttgata caagcgcgat 846721 ggagaaaagc atggagttta tcggcaagca taagcctgac ttcatcgaag tgcttcccgg 846781 catcgttccg tcactcattc aggaaataaa agagaaaaca gggattccca tctttgccgg 846841 gggtttcatc cgtacggaag aggatgtaga gcaggcattg aaagcggggg ctgtagctgt 846901 cacaacatct aataccaaat tgtggaaaaa atatgaaaac tttttgacgg aaagtgattg 846961 acaccgcttt catgcactga tacaattgca ctaggttaat acattgtgat ggagaactcg 847021 gagaccacag cagctcttta cggcaaatgt ttatgcaccc gtaaagcggt ttgttgtggt 847081 ttttttattc tcttcttctc tatcatgctt tttaatcgtg actttaggag gaatgtgcta 847141 tgacagcatt ttggggagaa gtcatcggta cgatgctgct tatcattttt ggtgcaggtg 847201 tttgtgcagg tgtcaattta aagaaatcgc tttcattcca gtctggctgg attgttgttg 847261 tatttggatg gggattgggt gttgccatgg cggcatacgc ggttggcggc atcagcggtg 847321 cccatttgaa tccggcgcta acgatagcgc ttgcatttgt aggagatttt ccttggaaag 847381 aggttccggt ttatattgcg gcgcaaatga tcggagcgat catcggtgcg gtgattattt 847441 atctgcatta cctcccgcac tggaagtcaa cggatgatcc cgctgccaag ctgggtgttt 847501 tctcaacagg gcccagcatt ccgcatacat ttgcaaacgt tttaagcgaa gtgattggga 847561 catttgtcct tgtacttgga atcttggcca taggtgcaaa tcaatttaca gaaggactta 847621 atcctttaat cgtcggtttc ctcattgtag caatcggtat ttctctggga ggcaccaccg 847681 gctatgctat caatcctgca cgtgacttag gtccgcggat cgcccacgct tttcttccga 847741 ttccggggaa gggctcatca aactggaaat acgcatgggt tccggtagtc ggcccgattt 847801 taggcggatc attcggcggt gtattttaca acgctgcatt taaagggcac atcacaagca 847861 gcttctggat tgtaagcgtt atattggttg tggtattgtt aggactctat gtttatacga 847921 aatcacattc tgctaaaaca ttatcaaatt ctaaatatat ttaatcaaag gggagacatc 847981 ttatggaaac gtacatttta tccttagatc aggggacgac aagttcaaga gcgattctgt 848041 ttaataaaga aggcaaaatt gtccactctg ctcaaaagga atttacacaa tacttcccgc 848101 atcctggctg ggttgagcat aatgccaatg aaatttgggg ctctgtcctc gcggttatcg 848161 cctcagtcat ctctgaatca ggaatcagcg cttctcaaat tgccggcatc ggcatcacga 848221 accagcgcga gacgacggtt gtgtgggata aagatacagg aagtcctgtc tataatgcaa 848281 tcgtttggca gtccagacag acgtccggca tttgtgagga acttcgtgaa aaaggatata 848341 atgataaatt cagagaaaaa acagggcttt taatcgatcc ttacttctcc ggcacgaagg 848401 tgaagtggat tttagacaat gtggaaggcg caagagaaaa agcggaaaaa ggcgagctgc 848461 tgtttggaac gattgatacg tggctcattt ggaaaatgtc aggcggaaaa gcgcatgtga 848521 ccgattactc caatgcctca agaacactga tgtttaatat ttacgattta aaatgggacg 848581 atgaactgct cgacattcta ggcgtaccga aatccatgct ccctgaagtg aagccgtcct 848641 ctcatgtgta tgcggagact gttgattatc acttcttcgg aaaaaatatc ccgattgctg 848701 gagcggcagg cgaccagcag tccgcattgt tcggccaggc atgctttgaa gaaggcatgg 848761 ggaaaaacac ttacggcaca ggatgtttca tgctgatgaa taccggggaa aaagcaatta 848821 agtccgaaca tgggcttttg acaacaatcg cttggggcat tgacggaaaa gtgaactatg 848881 cgttagaagg gagcattttt gtcgcaggct ctgccatcca gtggcttaga gacggtttga 848941 gaatgttcca ggattcatcg ctaagcgaat cttatgcaga aaaagtggat tcaactgacg 849001 gcgtgtatgt tgttccagca tttgtcggac tgggaacgcc ttactgggac agcgatgtgc 849061 gcggttcggt tttcggcctg acaagaggga caacaaaaga gcactttatc cgtgcgacac 849121 tggagtcatt ggcttatcag accaaagatg tgcttgacgc aatggaagca gattcaaaca 849181 tttcattaaa gacgctccgt gtagacggag gagctgtaaa aaacaatttc ctaatgcagt 849241 tccaaggaga cctgttgaat gttcctgtgg agcgcccgga aattaatgaa acgactgcac 849301 ttggcgcggc ttatttggcg ggtatcgctg tgggattctg gaaggaccgt tctgaaatcg 849361 cgaaccagtg gaatctggat aaacggtttg agcctgaatt ggaagaagaa aaacgaaatg 849421 agctgtataa aggctggcaa aaagccgtga aagcagctat ggcttttaaa taaagtaata 849481 ctatggtata atggttacaa gttaataaga acggtcctga gatgaggaga gaccacagca 849541 ccaaagtgta agcatgcact ttggctgttg tggtctcttt ttctatttac cgtgacaaca 849601 aggaggaaac gtaatgatga atcatcaatt ttcaagtctt gaaagagatc gcatgctgac 849661 agacatgacg aaaaaaacat atgacctatt tattatcgga ggaggaatta caggagccgg 849721 aacagctctt gacgcggcat caaggggaat gaaggtcgca ctaagcgaaa tgcaggactt 849781 tgcggcggga acatcaagcc gatcaacgaa gctggtacat ggcggcttgc gctatttaaa 849841 acaatttgaa gtgaaaatgg tcgctgaggt aggaaaagag cgggcgattg tgtatgaaaa 849901 cggcccgcat gtcactacac cggaatggat gctgcttccg tttcataaag gcggcacatt 849961 cggttcattt acaacatcta ttgggttaag ggtttatgac ttccttgcag gtgtgaaaaa 850021 gtcagaacga agaagcatgc tttcagcaaa agaaacgctg caaaaagagc ctttggtgaa 850081 aaaagacggc ttaaaaggcg gcgggtacta tgtggaatac cgcactgacg atgcgagact 850141 gaccatcgaa gtcatgaagg aagcggttaa attcggggca gagcctgtga attactccaa 850201 agtgaaggag cttctttacg aaaaaggcaa agccgtcggc gtattaattg aagatgtgct 850261 gacaaagaaa gaatataaag tgtatgcgaa aaaaattgtc aatgctacag gcccttgggt 850321 cgatcagctc agagaaaaag accattcgaa aaacggaaag catttgcagc atacaaaagg 850381 cattcacctt gtatttgacc agtctgtctt tccgctgaaa caggctgtat atttcgatac 850441 acctgatggc cggatggtat ttgcgattcc tcgtgaaggc aaaacatacg tgggaacaac 850501 agacactgtt tacaaagagg cgctggagca tccgcggatg acaacggagg atcgtgatta 850561 tgtcatcaaa tcaatcaatt acatgttccc ggaactgaat atcactgcga atgacatcga 850621 atccagctgg gcggggctgc gtccgctgat tcatgaagaa ggcaaagatc cttctgaaat 850681 ttcacggaaa gacgagattt ggacatctga ctcaggcctg atcaccattg ccggcggaaa 850741 actgactgga tacagaaaaa tggcggagca catcgttgat cttgtccgtg atcgcttaaa 850801 agaagagggc gaaaaggatt ttggaccatg taaaacgaaa aacatgccaa tctctggcgg 850861 gcacgtcggc ggttcgaaaa atcttatgtc cttcgttacc gcgaaaacaa aagaaggaat 850921 tgcagccggt ttatcagaaa aagacgcaaa acagcttgcg atcagatacg gctctaacgt 850981 agatcgcgtc tttgaccggg tagaagcgct gaaagatgag gccgcgaaac gcaacattcc 851041 ggttcatatt cttgctgagg cagaatacag tatagaagaa gagatgactg caacccctgc 851101 tgacttcttt gtccgcagaa cgggacgttt attttttgat atcaattggg taagaacata 851161 taaagatgcc gttattgatt ttatgagcga gcgattccaa tgggatgagc aggcgaaaaa 851221 caaacataca gaaaacctca acaagctttt acacgatgcg gtcgtaccgc ttgagcaata 851281 aatcataacg ggctgtctgc agcccgttat ttctttttac gtgccgaaag ggggagatct 851341 caggttatca agtgacagag gcacccgctt catataaaat aatggcataa gctgatacat 851401 aggaggacga atatgacttg gagaaagagc tatgaacgct ggaaacagac agaacattta 851461 gatctggaat taaaagagcg ccttattgaa ttagagggag atgaacaggc ccttgaggac 851521 tgtttctata aagaccttga attcggtacc ggcggaatgc gcggggaaat cggcgccggg 851581 acaaatcgga tgaatattta cactgtgcgc aaagcatcgg ccgggtttgc ggcatacatc 851641 tcgaagcaag gtgaggaagc gaaaaaacgg ggcgttgtca ttgcttatga ttcccgccat 851701 aagtctccgg agttcgcgat ggaagcggca aaaacacttg cgacacaagg catccaaaca 851761 tacgtgtttg atgagcttcg cccgacgcca gagctgtcat tcgctgttag acagctgaac 851821 gcttatggtg gaattgtggt aacggcaagc cataacccgc ctgaatataa cggctacaaa 851881 gtatacgggg atgatggcgg ccagctgcct ccaaaggaag cggacatcgt cattgagcag 851941 gtaaacgcga ttgaaaatga gctgacgatc acagtggacg aagaaaataa gttaaaagaa 852001 aaaggcttaa tcaaaatcat cggtgaagat attgataaag tttatacaga aaaactgacg 852061 tccatttctg tacatcctga attatcggaa gaagtagatg taaaggttgt tttcacaccg 852121 ctgcatggaa ctgcaaataa accggtcaga cgcggtcttg aagcactcgg ctacaaaaat 852181 gtaacggttg tcaaagaaca ggaactgccg gattcaaact tctccactgt tacatcgccg 852241 aacccggaag agcatgcggc attcgaatat gccattaagc ttggggagga gcagaatgca 852301 gatattctca tcgcgacaga tcctgatgct gaccgcctcg gcatcgcggt gaaaaacgat 852361 caaggcaaat atacagtgct gacaggaaac caaaccggag cgttgctgct tcattacctg 852421 ctttctgaaa agaaaaaaca aggcatcctg cctgataacg gtgttgttct caaaacgatc 852481 gtcacaagcg aaatcggccg tgctgtagct tcttcattcg gccttgatac gattgatacg 852541 ctgacaggct ttaagtttat cggtgaaaag attaaggaat acgaagcatc aggccagtat 852601 accttccaat tcggttatga agagagctac ggttatttaa tcggggattt tgcccgcgat 852661 aaggacgcca ttcaggctgc gcttttggca gttgaagttt gcgcgttcta taaaaaacag 852721 ggaatgtcat tgtatgaggc gctcatcaat ctctttaacg aatatggttt ttatcgtgaa 852781 gggctgaaat ccctgacgct gaaaggcaaa caaggagcag agcaaattga agcgattctt 852841 gcttccttca gacaaaatcc gccgcagaaa atggcgggca aacaggttgt cacagcagaa 852901 gattacgctg taagcaaacg gacgcttctg actgaaagca aagaagaagc catcgacttg 852961 ccaaaatcaa atgtattgaa atacttcctg gaagacgggt cttggttctg tctccgtcct 853021 tctggaactg agccgaaggt taaattttat ttcgccgtaa aagggtcatc tttggaagac 853081 agtgaaaagc gacttgccgt cctttctgaa gatgtaatga agacggtgga tgaaattgtt 853141 gagtcaacag caaaataatt caagtatgag ctgggtcatt gtaaatgatc cggctttttc 853201 tttttctcat ccaaaagtct gaaagaaaat catcctacaa gtgaagcaat gaaatacaaa 853261 aaactggtat aatcttaaat acaagatcaa tgccggagtg agaaacgtga gcaaaacgag 853321 gatggaaaaa ttaaaaacgc tgaaaacgat tgcggaaacc ttaaatcaag ggcacgatat 853381 caaagcaaca ctggatgagg ttttaaaaga gttgctgagt ctgacaaacc ttcaatccgg 853441 atggattttt ctgatcgaag aagatgggtc ttatacgtta gcggccgacg cttatctgcc 853501 cccggcttta agccgcaagg aaaaagtgct gatgtgcgaa ggggagtgtt actgcctgac 853561 gaaattcaat aacggagggc ttagaaaagc tgcaaatatc atgaactgca aacgcatcga 853621 atcagcagaa aacctgcatt gttttgacac agaagggatt acgcatcatg caactgtgcc 853681 tttagaagac ggggacagaa gattcggatt gttaaatgta gcggcggccg gaaaaaccat 853741 gtttgatgag gaagagctgc atttactcga gtctgtcgcc tttcagatcg gaacggcaat 853801 ccagcgtatg aggctttctg aatatcaaca aaaaaatgct cttttaatgg agcgtaaccg 853861 cctcgctcag gagcttcacg attcagtcaa tcaaatgctg ttttccgtca gtttaactgc 853921 caaagctgcg aagacactaa caaaagatga aaatttacag cagatgattg atttcatcca 853981 aaacctatca caggacgcgc tcgcagaaat gaaagcgtta atttggcagc ttcgccccgg 854041 aggattggaa aaagggctgg ctgaagccat taaaagctat ggtgcgctca ttggattgaa 854101 gatcattttt acacaaaaag gctgtcctgt tctgactgat gagcaggagc atatgctatg 854161 gcgtgtcgta caggaagctt taaataactg caaaaagcat gccggaacgg atacggcgta 854221 tgttagtctg actgcttctt tgtgccatgc ggagctggat atcatcgatc atggggcagg 854281 atttcgctat gaagcgcatg ccggtctgcc ttcacttggc ataaaaggta tgaaagagcg 854341 agcggaaaaa gccggagcta agttttggat tgagtcagcg cttggaactg gaacaaagct 854401 gtccatcagg cttccgctaa aaagccgaaa aggaggggcg gtatgaaaat tgtcattgct 854461 gatgatcatc atgttgtcag aaagggtctg cgttttttct ttgccaccca ggatgatatt 854521 gaagtcgtcg gagaagctgc aactggatta gaagccctcc gtgtcatcga agagacaaag 854581 ccggatcttg tgctaatgga tttgtctatg cccgagatgg acggcattca agccattaaa 854641 aaagcaatac agcaatttcc ggatacgaat atcattgtgc tgacgagcta ctctgatcag 854701 gagcacgtca tccccgcgct tcaggcaggc gcgaaggcgt atcaattaaa ggatacggag 854761 cccgaggaat tggtgaaaac acgacaagtg catggtggcg aatacaagct ttctacagct 854821 attatgcccc atgtgctgac acatatgaaa aatcagcacg acccggaaaa agaaaaatac 854881 tatcaattaa ctagaaggga aaaagacgtt ctgactgaaa tagcgaacgg gaaaagcaat 854941 aaagaaatcg cagcagcctt gtttatttca gaaaaaacag taaaaaccca tgtatcgaat 855001 cttttagcaa aacttgaagt ggccgatcgc acgcaagcag cgcttttcgc agtgaaatat 855061 aacctgaatg gagagatctc aaaatgaaca tgttagtcat aaatggcacg ccaagaaaac 855121 atggcagaac aagaattgca gcatcctata ttgcagctct gtatcacacg gatttgattg 855181 atctaagcga gtttgtattg cccgttttta acggtgaagc ggaacaatct gaactgttga 855241 aagtacagga gcttaagcaa cgcgttacga aagcggatgc gattgtatta ttatcgcctg 855301 aatatcacag cggcatgagc ggcgctttaa aaaatgcctt ggattttcta agcagcgaac 855361 aattcaaata taagcccgtt gcattattgg cagtagcggg aggcggaaaa ggcggcatca 855421 atgcgctgaa caatatgaga actgtgatgc ggggtgtcta cgccaatgtc attccgaagc 855481 agctggtgct tgatccggtg catattgatg ttgaaaatgc tacagtggct gaaaacatta 855541 aggaaagcat aaaagagctt gtcgaagaac tcagcatgtt cgcaaaagca ggaaatcccg 855601 gcgtctaaac gccgggattt gtttatgtga gaagggctat ttgatcttca taagtcagct 855661 ctgtggcatg atcaatatat cggagaaggg aatacagcat cttttctaaa acggcgtaat 855721 cctgttcaaa atgatacgca tgcagaaaat gctcaattcg ttttgataac aaatcgtcct 855781 ctgtacgcac cattaaaatt aataaattat cccattgaga acgatgggtg taataaagcg 855841 ctttatcgta atcggcataa tccatgaatc gcttctcctt tcttgggtga gaagttcatg 855901 attagtttat gccgcatcct ctgttattga cggggcaaaa cttgccgtct gcgtcagtaa 855961 aggggtagca atatgaggga gacataaaat caaaatgcct gaatgaagat atcgcttttg 856021 gtaaacctat gagggaatat attctgggta caggagactg aaaaaatgaa atccctgccg 856081 tataccatcg cacttctttt ttgcggattg attatcgtgt caatggctgc aaaaggtcat 856141 tcaacggaca cagacgagtc cgttcaaaag tgggaacagc ttgcctggag caaaattcag 856201 gatgaatata agggcgcttc attttctgat tatgcttata tggggcgtac agaggtgaat 856261 gatcagcaga ctaaagatgt ctttcgggtg acagtcagac agaaagatga cactttttct 856321 gttcgggccg aagtctattt tcatccggtg acaaatcata tgatcagcat caacgtcttt 856381 aggctctaat aaaaaactgt acagccgtta aggccgcaca gtttctgttt ttagaaatat 856441 cgttttgcac cgagatagcg ctgtttccag taagagttgt tcatattgga aatgacaact 856501 ccggaatcgt tggcatttat gaattccccg ttgcctaggt aaattccgac gtgggaaggg 856561 ccggctttat atgttgaaaa gaaaacgaaa tctccgacag caggctggct aactgatttc 856621 attgtgttcc aatatcccgc tgccgttaat ctagatacgg atgtgacttt gttcagtaca 856681 tagtaaatga atccgctgca gtcaaacccg gacggtgtcg tgcctcccca gcgatacgga 856741 accccaagct gcgctttagc ggccgaaatc attgtgttaa tcttcgcact cgttgagctg 856801 gtggtgtttg aagaaccgga tgaagacgat gatgaagctt ttccggaaat gaccagcttt 856861 tggccaacct gcaagacatc cgtttttaaa ttgtttttct cacgaatctg ctgagctgtt 856921 acattaaatt tttgagcaat cacccataag gaatcaccgc ttttcaccgt gtatgtagtc 856981 gtcgtgccgg agcttgcatt tgacgaagaa gacgacgatg atgaagagcc tgaagatgct 857041 ttacctgtca gcttcaatac ttgtccaacg taaagcacat ctgatttcag attgttgata 857101 tttcggattt gctgtacagt caggttatag ttgtttgcga ttttccaaag tgaatcaccg 857161 cttttaacgg tatatttagt tgttgctgaa gtttggttcg atttggatga attgtcttta 857221 gaagacgtat cagagccgct tgattttgtt ttcaacacct gattcacgta aatggtgtct 857281 gattttaagt tgttcaagac cttcaattca gcgatggaca tattgacttt gtttgcaatt 857341 ttccaaagtg aatctccaag ctgcacctta tatgttcccg tagaagatga agaacttgaa 857401 ctcttattag aactgctttt tgaactggag cttgaactct tattagagtt gcttttttta 857461 ctggaactag agcttgaaga aacagtaccg gacaccttta atttctgccc agcacgaatt 857521 aaatcgctgc ttagtccgtt taattttttc agttcctgca ccgtcatttt aaactcattt 857581 gcgatcagcc aaagtgaatc tccgcttttc actgtgtaaa cagaacttcc gctcttcttg 857641 gttgttgagc ttgaagtaga tgaagaagtg ctggatttgc tgcctggaat agtaagcgtc 857701 tggccgatcg acagaacagt agtcgaaaga tgattggcgg atgtgagggc cgccacactt 857761 gtgttatagg tttgggccag tttccataaa gaatctccgc ttttgacctt aatcgttgct 857821 gcttcagctg gtgtcactac taaagttgtg ccgacaatcg cagatgctgt cagccctgct 857881 gctaatttct ttttcatctt agctctcctt tttcccccaa tgattttgca tttgctgttt 857941 cttttttata tcggcacatt tgtctcatcg ttttgccttt ttataaaaat agccaaatta 858001 tcttaacaat aagggggaaa aagggcataa aaaaagaagg aatcttaatc tattccttca 858061 tttttaaaag cttcatgata tcttctttgt ttttgacgag gtcgcgcagt gtgtatttgt 858121 ctaaaactgc gaggtaggct aaaagcgctt cattcagcac atgttttaag ccgcaaaccg 858181 gggaaataac acagagattc ttgttcgcat caaaacattc aacaatatta aaatcgtcct 858241 ccgtttttct gacaacctca ccgatgttga tgtcttcagg gtccatgcct aatcgtatgc 858301 cgccgccccg tccgcgtatc gtttctacgt agccgagctg gccgagcctg tatatgactt 858361 tcatgagatg attttttgaa atagaatacg tttcggcaat ctgttttata tttgaaagtt 858421 ctccgggacg ctctgcagcc agaaaaatca acactcttaa tgaataatct gtataattgg 858481 ttaacttcat aataagacct cagaataaga cattttctat atcttatcat aatcgattga 858541 aaaatgaaaa aaaaggaatt aaaaaacatg cacccagctg ggtgcatgtt ttttgcttac 858601 atgtcattcg gcggattttg gtttttacgg tttttttcga tttctgtgtt ttgcattttg 858661 cgttcaaatg tagacagata acgtgatgca aaatccttac cgccaaggcc gaaggataaa 858721 ccaaaagcaa gtgcgaagcc gctaagaacg atgatgaacg cggaattgac gattgtcgca 858781 gcgacaccca gctgatccag ggccataaag aaagcaagtg cgataatcgt atatttagca 858841 ataggcgcta aagacttgaa ttcctgacct tttatcatgc ttgcgagcac ttttctcacc 858901 aattctcctg cgtaaaggcc gagtccgaga atgaatactg cgacaaggac attcggcaga 858961 tacgcgatga tgccggtggc aatttctacg aggaagtgca gccgaacaat ttgaagcgcc 859021 tcagctgtaa agagcagaat gacaatgatt tgcgcaatca taccgacaac ttgagacaag 859081 gacagctttg caggcgttcc ggcttccatg cccattttcc ctaagacaga atcaaagcct 859141 gcgcgatgga gcagtccgga caccatggat ttcacccatt ttcctgccca gatacccgct 859201 aatacaagca cgatggcaat catgatgttc ggaagcatgt ttaaaatcgt attcagcata 859261 gagacagctg gttttgaaat gccggcgaca tccagctgat caagcgctga aatgaccacc 859321 ggaatcataa tgagcacata agcgattgtt ccgatgactg ctgaaaggct tgtgtctttt 859381 aagtaaattg ataaacccat acgtgccgcg aatctttcgg tgccgatgct tgcaaggaaa 859441 ttcgtaatga tatcacggac aaggcgggca acaagccatc cgattaatac gataagcgcc 859501 gctgcaaata atttcggcag aaaagcgagc acgctttcca tcatatttgt aaaaggacct 859561 gaaatgccgc tgattttcaa agaagataag acccctggca gaaaaacaag cagcacgaga 859621 taaaagacaa tttgtgaagc ggtattgaca gcctggtgaa tatcttttcc ttcagacacc 859681 aaattccact tgcgcagttt gtcactcgtg ttcagcttca tcccgatttt tttgacaagg 859741 aagctcaaaa cagaagctgc agcccatcct aacagcagaa tgagtccggc tttcagcacg 859801 cttgggatcg cagctgcaat cgccgaaagc atactgacaa acggcgatgc cactgttgtc 859861 aggtgcaaaa tgttaaagaa taaaataaag acgatgatca gtgcgataaa ataaacgacc 859921 ttgcttatga ctttttccga ggaatagcgt gaaggctttt tcccagcaaa gagcttgtcg 859981 tcgatttttg ttttgctgag tcctttgtat accgcttttt caatgatttt agcaatagcc 860041 cagccgatta ataagacgag taaagcaatg attacgtttg gcagcttact gagataagaa 860101 gaaaacacgt ctgctacatt caattggtat cgctcctttt tcgtagtatg gtgtgtgttt 860161 acccacttat ccaataagca aacagatgaa tgtgccgggg gaattttttc ttgcccgagt 860221 gagactatca tcttttgtct ggcgggctca tacattatag ataagtccaa gtagggggga 860281 ttcggttgaa cgcggaggag aagaagggat tacagcgggc aattgaggaa attaccgaaa 860341 ttgcaaaagg attcggcctt gatttctacc cgatgagata tgaaatctgc ccggctgaaa 860401 ttatttatac atttggcgcg tacgggatgc cgacaagatt cagccactgg agcttcggca 860461 agcagtttca caagatgaag ctgcactatg atctagggtt aagtaagatc tatgagctgg 860521 tcattaactc agatccatgc tacgcttttt tgctggacag caactcactg atccaaaata 860581 aattgattgt cgcacacgtt cttgctcatt gcgatttctt caaaaacaac tgccgtttcc 860641 aaaacacgaa gcgcgatatg gtggaaagca tggcggcaac agctgaacgg ataaaacact 860701 atgaacaggt tcacgggata aaagaagtcg aatctttttt agatgcaatc ctttcgattc 860761 aggagcatat cgatccgtcg ttggtccgac caaagctcca atggagtgtg gatgatgagg 860821 aagaggagat tgaagaggca gccacgcctt acgatgatct atggtcttta gatgaaaaga 860881 aaccgaaaaa acaagtgaaa aaatcgaaaa aaccgttccc gccgcggcct gaaaaagata 860941 tcctgctttt tatcgaggag cattcccggg agctggagcc atggcagcgt gatatattaa 861001 cgatgatgag agaggaaatg ctttatttct ggcctcagct ggaaaccaag attatgaatg 861061 agggctgggc ttcctattgg caccagagaa ttatacgtga gcttgattta acctctgatg 861121 aagcgatcga gttcgccaag ctgaatgcag gtgtcgttca gccgtccaaa acaggcatta 861181 atccttatta tttagggctg aaaatatttg aagacattga aaagaggtac aacaacccga 861241 cggaggaaat gaagaaaatg ggcgtgcagc ctgactccgg ccgggagaaa atgtttgagg 861301 tcagggagat tgaatccgat atctctttca tccgcaatta tttaaccaaa gaattagtca 861361 tgcgcgagga tctttatttg tttcaaaaac agggccgaga ttataaaatc atcgataaac 861421 agtggaagtc ggtgcgcgac cagctcgtaa gcatgcgggt aaatggcggt tttccatatt 861481 tgacagtaaa cgacggcgat tatatgaaaa ataacgaact ctatattaag cattggtatg 861541 agggcataga gttggatttg aaatatttgg agaaagtgct tccttattta ttccagcttt 861601 ggggaagaag cgtgcacatt gagtctgtgc ttgaggataa ggaagtcatg ttttcgtacg 861661 acggaaaagg tgttcaccgc agatatttat aaaaaagagg atgcagcgtt ctgcatcctt 861721 tttattttcc agtttttaaa atcttaaata tgatgtttgc ctggtccgta ttgttaatca 861781 atccgcggaa tttttctttt ccggggccgt acgcgtatac cggtacttct tcgccggtat 861841 gatcggtact cgtccatccg ctgttggagc gggtattaaa aatcttgatg atggctttgg 861901 aggccccttt gcttttgtca gcctgtgcag ctgcttcaac gcttttgatt tcttcagatg 861961 tgactttcag attggcatag cgggcgagca catctttaac cggcttgcct tcactgattt 862021 ttttggccat gaattcaggt gttttcttag cggagagaat cggttctgcg tgccaattct 862081 tttccccgtt tgcgccaatg gtaaagccgc cggttgtatg gtcagcagtt gcaatcacaa 862141 gtgtatgttt gtcttttttc gcaaattcaa tcgcggcttt ataggcctgt tcaaaatctt 862201 taacctcgct catggctcct actgtatcat tgtcatgggc cgcccagtca atctggctcc 862261 cttcgaccat caagaaaaat ccttttttat tttggttcag gcgatcaatt gctgaaaccg 862321 tcatgtcttt gagagacggt gttttactgt cacggtcgag cgctttagca agccctccat 862381 ctgcgaaaag cccgagcacc tgctgatctt tatttttttt caatgcttgt ttagttgtca 862441 catagctgta gccggcttgt ttgaattcct ttgtcaagtt tctgtccttg cggttaaaat 862501 aagattttcc gccgccgagc agcacgtcta ttttatgttt gccttttatc ttgtcatcca 862561 tatagctgtt ggcgatttgg tccatgtttt tccgtgattc attgtgggcg ccatatgcgg 862621 ctggagtggc gtggttaatt tcagacgtgg cgacaagccc tgttgacttg ccttgctgtt 862681 tggcctcttc aagtacagat ttcacttttt ttccgttttt atcgacgcca attgcattgt 862741 tatatgtctt aacgcctgtc gctaatgctg ttccggctgc tgctgaatct gtaatattat 862801 agtcagggtc atccggatgc gtcatcatca tgcctgtcag gttccggtca aattctgtta 862861 acttcgggtt attcggtgtg tcaccgttat ttttcatgga acggtaggct cttatgtaag 862921 gcgtccccat gccgtcgcct atcatcacaa tgacatttct gatctcagct ttgtcttgtt 862981 ttttggcgct ggccttttct gtttgctgaa gctcagctcc ggcaaagatt ccagctgtaa 863041 ggacagaaac agcggcgatt ggcagaagtt ttgatttcat attttgaaac aaactcattt 863101 ttttcatgcc tcctttaatg tattccgttt atcatgttag ggaaactttg ttaaatgcgg 863161 ctgttgatca tgtaaacaat aagtaaagcc ttgtaaggaa atgaaaaaac gcttttcgtt 863221 atcttgcctt atttgatgta aagcattcat ttttcagaaa aatctttacc tctctgtctt 863281 tgcatgatat gtttgtttaa ataaaaaaac tgcggataac cacagctctc ctcgaatata 863341 ctttatcact catttttccg atatatgagc cgaccccgaa agtttttcat ttatttcctt 863401 tatgttgaaa aacatcccat aaaacatgac aaaagcactc gttttttgtc acctttgcaa 863461 tgaaaatgaa atatttaata cccttaaaaa ctttttttta gaacgaataa ttaagaaatt 863521 tgtcacatga agtcaagact atttctgatg ggaatctatc cttataatag aaatcaataa 863581 gattaattta aaaaaagaga tacatatata tagagttaac atttggggag gaaaatatga 863641 aaaagcaaat cattacagct acgacagcag ttgttttagg atcgacgtta tttgcaggag 863701 cggcatctgc acaaagcatt aaggtgaaaa aaggcgacac gttatgggat ctttcaagaa 863761 aatacgacac aacgatcagt aaaattaaat cagagaacca ccttcgttca gacattattt 863821 atgtgggaca aactttatcg attaacggca aatctacaag ttcaaaaagc agcagttctt 863881 cttcctcttc ttctacatac aaagtaaaga gcggggacag cctttggaaa atttcaaaaa 863941 aatacggcat gacaatcaat gaactgaaga agctgaatgg cttaaaatca gatttgcttc 864001 gtgttggaca agtcctgaaa ctgaaaggtt caactagttc aagcagctcc agctcatcaa 864061 aagtgtcatc gtcttcaact tctacttata aagtgaagag cggagacagc ctttctaaaa 864121 ttgcgagcaa atacggcact acggttagca aattaaaaag cttaaacggc ttaaaatcag 864181 atgtaatcta tgtcaaccaa gtattgaagg tgaaaggaac aagcacaagc agctcaaaac 864241 ctgcttcatc ttcatcgtct tcaagcagca aaacgtcatc tacatcactt aatgtgagca 864301 agctggtttc tgatgcaaaa gcgttagtcg gaacgccata taaatggggc ggaacgacaa 864361 cttcaggctt tgactgcagc ggattcattt ggtacgtact gaataaacaa acaagtgtgg 864421 gcagaacaag cactgcagga tactggagtt ctatgaagag cattgccagc ccgtctgttg 864481 gtgatttcgt cttcttcaca acatataaat ccggcccttc tcacatgggg atttacattg 864541 gaaacaacag tttcattcat gcaggatctg acggcgtaca aatcagcagc ctgaacaaca 864601 gctactggaa gcctcgttac ctcggtgcga aaagattcta atttttagag aaaacccgtt 864661 cattggaacg ggtttttttc attagacgga gcacaggcgt tttggttgct cctaaaaatg 864721 aaaatgtgat aaaaaatcca agaacttttt ttctttctta ttttcataaa gggcaatcgc 864781 gtaagcgccg gcatagggca gctgtacaga ctgataagga attctgatca tctgtttctc 864841 tgctaactca cgctttactg tagataaagg cagaaatgaa actccgagtc cttccttgat 864901 aaaccgtttc gttatatgtg tttgagtgac cttcattgtt ctcacaaatg gaaatgtcat 864961 tctgacttga cggagcaagt cgtcccagta atcaggatga ttgtgggtca aaagcaggta 865021 ttgttcgagc acctctttgg catcaatttc gttgtcttct atgaaacgct tatcgggcgg 865081 ggcaacaagg acgacagggt ctttgtataa gcagtggcag cttaaagaag aagactgtac 865141 ctttaaacag cttagtccga tatctgcttc cccggcttta atcagtgacg cgatttccgc 865201 tgattcgaaa atcgtaaccg ccatttctgt ttccgtattc attgctgtgt accgcttcat 865261 gacagaagga agcactgtat ctgcaataag cggagaaacc gcgagctgta aggtttgaga 865321 gtagccttgt ctcactctgt gaagctctgc catgctgttt tcataatcat caagaagcct 865381 gagcgcatac ggcaaatacg ccctgccttc atcagtcagc tggatttgcc tgcctttacg 865441 ctcgaacagc ttgcagctga tttctttttc taattgcttg atatgtacgg tcacagtagg 865501 ctgagataag aaaagcgttt ccgccgtttt tcggaagttc tcatattttg cagcggtcac 865561 aaaggtgtga agccatttga aatccatttc tattctccct ctgattaata tttttaatta 865621 attcccttta aaatattgat tattttttaa atattatatt tactataata acagaaaagg 865681 atagggggaa tacaaatggt acattacgga ttaaagggaa ttacatgtgt agaaacatcc 865741 atcagccata ttgatggtga aaaagggcgt ctgatttaca gaggacatca tgcaaaagac 865801 atcgcactga atcacagctt tgaagaagcg gcttatttga ttttatttgg aaaactgcct 865861 tcaactgaag aattgcaggt atttaaagat aagctggctg cggaacggaa tcttccggaa 865921 catattgagc gcttgattca atcactgcca aacaacatgg acgatatgtc ggtgctgaga 865981 acggttgttt cagcattggg ggaaaatacg tacacattcc atccgaaaac agaggaagca 866041 atccggctga ttgcaatcac gccttctatc attgcataca gaaaaagatg gacgcgcggt 866101 gaacaagcaa ttgcaccttc ttcccagtac ggacatgtcg aaaactacta ttatatgctc 866161 acaggtgaac agccttcaga ggcaaaaaag aaagcgcttg aaacctatat gattctggcc 866221 acggagcacg gcatgaacgc atcgactttt tcggcacgag tcacgttatc tacagagagt 866281 gatttagtgt cagccgtcac ggctgctctc ggtacgatga aaggtccgct gcacggaggt 866341 gctccttctg cggtgacaaa aatgcttgaa gacattggag aaaaggaaca tgctgaagca 866401 tatctgaaag aaaaactcga aaaaggagag cgcttgatgg gattcggcca cagggtgtac 866461 aaaacaaaag acccgcgggc agaagctttg agacagaaag cagaagaggt ggccggcaat 866521 gaccgtgatc ttgatcttgc gctgcatgta gaagcagaag cgattcgttt gctagaaatc 866581 tacaaaccgg gacgaaagct gtacacaaat gttgaatttt acgcagctgc agtgatgagg 866641 gccatcgatt ttgacgatga attgtttact ccgacctttt cagcaagccg aatggtaggg 866701 tggtgcgccc atgtactgga acaggcagaa aacaacatga ttttccgccc gtcagcgcaa 866761 tataccggtg ccattcccga ggaagttctt tcataacata ttttggcgtt tattcatttc 866821 tgtcgtgtgg taacgttcag tatcaaccac atgtctagga gtgatgaatg tgaacccaat 866881 ggacagacaa acagaaggac aagaaccgca gcatcaggac agacagccgg gcattgagtc 866941 aaaaatgaat ccgctgccgc tgtcagagga cgaggattat cgaggaagcg gaaaactgaa 867001 aggaaaagtt gcgatcatta ctggaggcga cagcggaata gggagagcag cagctattgc 867061 ctttgctaaa gagggggctg atatctccat tctatactta gacgagcatt cggacgcaga 867121 ggaaacacgc aaacggatcg aaaaggagaa tgtccgctgc ctgcttatcc cgggagatgt 867181 tggggacgag aaccattgtg aacaagctgt gcagcaaaca gtggaccatt ttggtaaact 867241 cgatatctta gtgaacaacg ccgctgaaca gcatccccag gacagcattc tcaatatttc 867301 aacagaacag ctggaaaaaa cctttcgcac aaatattttt tccatgtttc atatgacgaa 867361 gaaagctttg cctcacctgc aagaggggtg tgccattatt aatacgacat cgattaccgc 867421 ttatgaaggg gatacggcgt taattgatta ttccagcaca aagggtgcga ttgtttcctt 867481 tacgcgttcc atggcgaagt cgcttgcaga taaaggcatc agagtgaatg cggtggcgcc 867541 cggtccgatt tggacaccgc ttattccggc gacattccct gaggaaaaag tgaaacagca 867601 cggcttggat accccaatgg gaagaccggg acagccggtt gagcatgcag gcgcctatgt 867661 tctgctggcg tctgacgaat cttcctatat gacagggcag accattcatg tgaatggcgg 867721 ccgttttatt tcaacgtaat caacgaaaaa ccagctcaag agctggtttt ttgtgtggtg 867781 aaaaatttca aaataaaaaa tttgtcgatt tttctaacaa ttttgttttc atttttgcaa 867841 ttttatatat aatattgagt aggagaaagg aatgattcgc gaccagtaca aatatagtag 867901 aaaaaaaaga ataatgacca ttgttactca tgaattcaga aaattcaaat aaaatatata 867961 aaaatagatg atcgggagtt gaaggggaat gaaagggagc gtttttagga agaaaagcat 868021 tcaggattta atcgctgcga cgagcgggga aaagtcttta aaaagagaat taggggcatt 868081 tgatttaacg ttgcttggaa tcggcgccat tattggcaca gggatttttg ttctgacggg 868141 aacaggcgca gtcacggccg gtcccgggct gacgatttca tttgttgtgg cggcgttggc 868201 ttgtttattc gccgccctgt cttacgcgga atttgcgtca agtgtgcctg tttcaggttc 868261 ggtgtataca ttcacttatg cgacattggg agagcttatg gcctttatta tcgggtggga 868321 tttaatttta gaatacatgc tggcggtaag tgcagtgtcg gtcggctggt ctggttattt 868381 ccaatcgttt ttatcagggc ttggcattca tcttccggtt gctttaacag cggcaccggg 868441 cgcagtgaaa ggcaccttta ccctgtttaa tcttcctgca ttcgtcattg taatggcgat 868501 cacatatttg ctttatttag gcatcaaaga atcaaaaaga gtcaacaata tcatggttat 868561 cttgaagata ctggttgttc tgctgtttat cgcggtggca gccgtttacg tgaagccgca 868621 caactggcag ccgtttatgc caatgggctt tggcggcgtg ttcagtgcag cggcgctcgt 868681 attctttgct tttatcggat ttgacgctgt atcctctgct gcggaagaaa cgaaaaatcc 868741 cgcgaaggat ctgcctaaag gcattatttt ctctttactg gtctgcacga ttttatatgt 868801 caccgtatca gccatcatga ctggggttat cccgtttgct caatttgcgg gtgtggatca 868861 tccggtttct cttgttcttc aaagcgcagg gcaaaattgg gtggcaggca tcattgatat 868921 tggcgccgtg ttgggaatga caacagttat gctcgtgatg ctttacgggc agacccgcgt 868981 catgtttgcc atgtcgcgtg acggacttgt gccgggttca ctttctaaag tgcatccaaa 869041 gcacaaaaca ccttatgtag ccacttggtt tttcggaacg atgtcggcgc ttctcggctc 869101 acttgttccg ctggatgaac ttgcaaagct ggtgaacatc gggacgttgt cggcatttgt 869161 cctgatttct gtggcagtta tcgttttgag aaagaaacag cctgatcttc cgagagcttt 869221 taaatgcccg ggagttcccg tgatcccagg cctggcgatt ctgttctgcc tgttcttgat 869281 tttaaatctg ggatgggtga cgattgtccg cttcctagtg tggctgttaa tcggcttggt 869341 aatctatttc ctgtattcaa gaaagcattc aaaattaaat caataacctt ttgataaaga 869401 gagcggccat acaggccgcc tcttttctgt tcttggcaaa tgaatctata gaaatgaaga 869461 caaaaataag agataatata ggctggaaag gaagtgacgt ttattgtctg agcaaaaacc 869521 agtccaatgg gcttcgaaaa ttggtttcgt catggcagcg gccggctcgg ctatcggctt 869581 gggcgcgatt tggaagttcc cttacgtagc ggggaccaat gggggaggag ccttttttct 869641 tatcttcgtg ttatttacca tcctcttagg ctatccgctt ttggtggggg aatttatttt 869701 tggaagacgg aaccagacga atgccattga tgcatataaa aaagaagcgc cgcgatcagc 869761 ttggtttctt acggggtgga tcggcgtagc ggcgtgtttc ttagtgctgt cgttttacag 869821 tgtaatcggg ggatggattt tgctgtatat cgtgaaaaca gcgtcaggat cactgtccgg 869881 gctttctcaa gcacagtatg gcgctctttt tgcttctatt atccaaaatc cggtgcagac 869941 gctcgcggct cagcttgtct ttatggcact gactgtactc gttgtcgcaa gaggggttca 870001 aaaagggatt gaacgggtaa gcgcggtgat gatgccgatt ttgtttttat tgtttattct 870061 gctcgttctt cggtctctta cgcttaatgg tgcaatggaa ggcgtaaagt ttctgcttgt 870121 gcctcatttc ggcgatctga ctccggaatc catattattc gcgctgggac aggccttctt 870181 tacgttaaca ctgggggttt cggtgatggt gacctacagc tcctatttgc cgaaaacaca 870241 aaatatccct cgttcggcag cctccattgt cttgatgaat atcattgtga cactcttggc 870301 aggtttggct atttttccgg cggttttctc attcggtttt cagccaaatg aaggaccgac 870361 attgctgttt acagtgcttc cggccgtttt tgaacagctt ccgttcggca cattgttttt 870421 tatcggcttt ctcgttgcat ttttatttgc agccttaacc tcagcatttt cgatggttga 870481 aattatcgtt gccacaatcg gaaaagggga cgaaaagaag agaaaaaaac tgtcatggac 870541 gagcgggctt ttgatctttt tggtcggaat cccatgctgc ttgtcttatg gcgttttgag 870601 tgatgtgcac ctatttggca aaacgttttt tgatattgcc gattttaccg tcagcaatgt 870661 tttgatgcct tcaggcgctc tgttaatttc tctatttatc ccgctgaaaa tttcgaaaag 870721 cgaactcttg gctgaaatgc gaaatggatc aaatgcaggt aaagcattct tttacacatg 870781 gttttatttg cttcgtttta tcgtgccgct tgccattatt atcgtgttct taaatttaat 870841 cggaatttta tcattttaaa aaacaggctc cgtttccggg gcctgttttt tatttaataa 870901 gatgatatca acggtgccca tgccgttttc agtttttgga tgccgagcct gatgtcctct 870961 tctgacaaac cgccataacc gattaagaca gaagtaaaag gcgtctgttc tatatatgag 871021 ggagacacgg gatagagggt tacaccgtgg tcagcggctg cttgtattgc ttcttcctca 871081 cttgctggaa acaaaaggcg cagcagaatg tgaagccccg agttcttacc gagaatctca 871141 acggtgtttc ccagttcaga gcgaatggct tctaacagga cagcgtgttt ttttcggtat 871201 aagcttctca ttctatttat gtgtttttgc cactctccgg tttcgatgaa gtctgccagt 871261 gccaattgcg agtgggcaga aacggtctgc ttcattaact gaacattgtt ttggatcggt 871321 tccatgagtt cagggggcac aatcatgaag ctgagccgca aggaaggcag aagtgacttt 871381 gaaaaagtgc ccagatatat gactctgcca ttcggatcaa gaccctgtaa agacggaatg 871441 ggatggccgc tgtagcgaaa ttctccatcg taatcatctt ctataatgaa tgaatttgtt 871501 tctgccgccc atgccagcag ctcctgtctg cgggtaatcg tcataatggt cccaatcgga 871561 aactgatgcg aaggagtcgt atacatgaga taaggattct gacggtagag ctcatccggc 871621 aggacgcctt ctgcatcaga acaaatcgga gtgacatcca tgtgatttgc ttcaaacatc 871681 cttcttgaac ggtgaaagcc cggttcttca aagccgattt ttgtacctgg ctttagcgaa 871741 aggcaaagat tttgcagaag cacggtggtt cctgcgccga tgataatctg gccgggttca 871801 caatttactc cccgagacag cctgacgaat cgggcaatca tgtgcctgag ttcgtattct 871861 ccttgagggt cgccagaggt gtgaaacgat ccggaatagc gatcaagact ttttactatg 871921 ctttttctcc atgcgttaaa gggaaagagg gtcggatcaa cgctgccctg atggaagtca 871981 atagcaggtg cgtttttttg atgtaatccc ggctgtacag actgctgaaa atggtcagga 872041 gctgtcggga atcctggttc tacttccgcc gcgaaccagc cgattttcgg cttgcttttg 872101 acatagccct cagcagttaa ttgctcataa gctcgttcta tagttgccgt gctgacatcg 872161 agcaagctgg agagcctgcg ttttgacgga agtcttgttc cctttgtgat tcgcgcatgt 872221 gaaatttctt gtttaaaaaa ggtataaagc tgttcataca gcggtgtttt gctcttttta 872281 tcaagaaacg gcgtaatatc catctcatgt ctcctttgta gctggcatgg tcattttttc 872341 tgatattggc tatttggcaa atgccattta ttagctatga tcattgtaac gaaaggaaag 872401 gggattgaga agatgatcca tatgaaacaa ttaacctcga aagaagaatg ggctgagtcg 872461 tatccgatta tgagtgaatt gagaacagaa ctggatatag agacgtattt acaaaggctt 872521 gaagcctgtg tgcagaaaga atcgtatatg ctgtttgcct tatatgaaaa tacagcaatc 872581 agagcgctgt gcggggctct gccgagagtt tccattcata aaggagagca cttgtggatt 872641 gcggatcttg ttacaacggc accttgccga tcaaagggat acggcaaaat gcttttggat 872701 tatgcctcag actgggcgag aaaagccgga ctcggttttg tcagtctttc atctggcctt 872761 cagcgtaaag acgcacatcg attttataca gataaaatgg gttttactat agaaagttat 872821 ttgttccgaa aaccggtata acgaaaaaag acgcctgaaa aggcgtcttt tttaaaagcc 872881 aaactgtaaa ttcgtatcta cagatacaat ggtatacaca caaataatca caaagagatt 872941 aaggatgacg ccgagcaggc ctggacctgt gcgccctctc ttgatgaaga gttcaacaac 873001 gccgaacgga acggcagcca tggcgaacgg aagcatttga taggaataaa acgtgacgtt 873061 gctgataatg gccaaattca gcaacagcag ggacagaacc gctgtcccga cagagatcca 873121 gccgaataca ttgtgttctt taaaaattct taccagttcc ataattccac ctcgccgaca 873181 ttcgctgatt ttacagattt atttttcagc atgcgctgga tttccttggt tggccctgta 873241 acgaccgaac cgtatacatt gacaccgttt ttctctacat aatctaatcg gttatctaca 873301 ttcaggtctt tccgttttga aatgacctga gcccattttt cgtgtttgga catgaatttc 873361 agggcgttga taaactgatc gccattcgac ttgccttttg tattaagggc ggccaagaac 873421 tttgaatcct ttccaggata gccaagaggt tctgtggaag ctgtcttatt tgtgtttttc 873481 tctgtttcga ttgcgttcca caaaaagctc acatcatagc ctttgaattt gttatacacg 873541 tcttttgtcg gatatgcacg gtcatatgaa aggtagacct ctgataccgt tccttcaggc 873601 aatgtgctta acgttttttc tgcttttgcg gtcgtttgtt cagacttgtt tgaaggatgt 873661 gtaaagtaat ggccggtttt attcacttct aagtcatagt agtttactgc cggcgctttt 873721 actttgttat aaaacatttc aacccgttca ttccctacgg cagccgtctt cgtgccaatc 873781 tgcttttgca gcgggaattc cgtattcatt ccaaatagct tcacttggct tttcagtccg 873841 gaagtatcaa caagaacatt cggcatggtc agggctacag tgactgcggc agtttccata 873901 aactcattgc cggtgctgtg ttttccaccc attccgtaat agaggtagct tcccagcgta 873961 caaagcggca aaatcatcaa tgtcgaaatg acggcaagca cagaaattcg caaataagac 874021 ttgcgtttgc cgtaggctaa aatcgctttt tgtttttcag gactgatgct gagatcccaa 874081 tcgttatcgt cctctagttc gctgtcaatc agttcctgat atacttcaag cttctcgagt 874141 tcttcctcaa atgcagtcat ttcctggtcg ctcatttccc catttttata ttgatcaaaa 874201 cgctttttaa attcttcatt catcattaac acctctatta taaagtgctt tcagccgctg 874261 tctggcacga aataaaacac ttttaaaatt cgcctctgaa atattcataa tatgggatgc 874321 ttctttgtag tttaactctt ttaaataata tagcgttaag gcctcccgat aattatcggg 874381 gagctcggac atataaccag tcagcacttc ctttatctct acctgatggg caggactttg 874441 aacagcattt tgaaagaggc ttccgattaa gtcatcagaa atggttactt ctttcttatg 874501 ctttctgacg taatcaatga aggcgtttcg cgccacttga aaaagccagg gctttacttt 874561 gctgtgatca taggagtgaa tgtgtatgta tgcccgcata aaggtttcct gcagtaagtc 874621 ttcagcaaga tgcttgtctt ttgtcatgga gagcaggaac ctgtaaacat cattcatgta 874681 catttggtaa atttcatcga tcgtcactgc cttttctccc ctctatgtta tacacgcata 874741 agaaaggttt aaagttgcac attacatgca aacggctttt ttatacctaa tcaaacacca 874801 ttactatata gtacccaaaa atggccgcaa aagatagtgc ggagaaaggt ttaacatttt 874861 ttccagaggg gaaaagatag tgaaaaagtg aaggagtggc acaatggaat ataccagtat 874921 agcagataca ggaatagaag cctccagaat cggcctcggc acatgggcca ttggcggaac 874981 gatgtgggga ggcactgacg aaaaaacatc gattgaaaca atccgcgccg ctcttgatca 875041 ggggattaca ctgattgaca ccgcaccggc ttacggcttc gggcagtccg aggaaattgt 875101 cggaaaggca atcaaagagt acggcaaaag agaccaggtg attctcgcaa cgaaaacggc 875161 tctggactgg aagaacaacc agctgttccg ccatgcgaac agagcgagaa ttgtagagga 875221 agttgagaat tctttgaagc ggcttcaaac agactatatt gatctttatc aggtgcattg 875281 gcccgatccg cttgtgccaa ttgaagaaac ggctgaagtc atgaaggaat tatatgatgc 875341 gggaaaaatc cgggcgattg gcgtcagcaa tttttcaatt gagcaaatgg atacatttcg 875401 cgccgtcgca cctctccata cgattcagcc tccatataat ctgtttgaaa gagagatgga 875461 agagagtgtc cttccttatg cgaaagataa caagataaca acattattat acggcagttt 875521 atgcagaggg ctgttaacag gcaaaatgac tgaagaatat acatttgagg gcgatgatct 875581 gcgtaatcac gatccaaaat tccagaagcc ccgctttaaa gagtatcttt ctgctgtgaa 875641 tcaattggat aagctggcga agacacgtta tggaaaatca gtgattcact tggctgtcag 875701 atggatctta gatcagccgg gagcggatat cgctctttgg ggagcaagaa agcctgggca 875761 gcttgaggcc ctatctgaga ttacaggctg gacgctgaac agtgaagatc agaaagatat 875821 caatactata ttggaaaata cgatatcaga ccctgtcgga ccggagttta tggccccgcc 875881 gaccagagag gaaatataac aaaagctgag ggcgaatcct cagctttttg gcgtttaaac 875941 gagagaaatc ttaaaaatta gtaccaggta ataaaaaata ttgttataat agatgacaga 876001 aagaatcatt gattacgaca aaggaagtgc gatatgtata agttttgtgc aaatgcttta 876061 aaagttattc tttctcttcg cggaggagtg aaggtgtata acaaagaaaa ccttccggcc 876121 gattcaggtt ttgtcatcgc gtgtacacat tccggctggg ttgatgtgat tacactcgga 876181 gtcgggattc ttccttatca aatacactac atggcgaaaa aagagctttt tcaaaataaa 876241 tggatcggtt cgtttctgaa gaaaattcat gcctttccgg tagatcggga aaatcccggg 876301 ccaagcagta ttaaaacgcc gattaagctg ctgaaagaag gagagatcgt cggtatcttc 876361 ccaagcggaa caagaacctc tgaggatgtg cctttgaaaa gaggtgcggt gacgattgcg 876421 caaatgggga aagcgccgct tgtccccgct gcatatcagg gcccttcaag cggaaaagaa 876481 ttattcaaaa aaggaaaaat gaagctgatt atcggtgagc ctcttcacca ggctgatttt 876541 gcccacctgc cttcaaagga aagacttgca gcaatgacag aggctttgaa tcagcggatt 876601 aaagaactag agaataaact tgatcagcta taaggcgttc tgagagattg tcctgaaact 876661 gtgaaaataa gaaaagcacc ctatacaagg tgcttttctt attatgcttc ctgctggtta 876721 gctgtctcca gaagttcttc ttcttgaagc tttttcactt caatatatgc gacgtggtgg 876781 ccgtcaattt cattaatgat gaattcgcag ccctcttcga tgatggaatc atctttttca 876841 acatcgtatt tttgagtaag gaaccagccg ccgattgtat cgacttcttc gttctctaaa 876901 tggatgccta gcaggtcgtt tacttggtca attaacactt ttccgtcaag aatataatgg 876961 ccttcgccga ttttgcggat ttcgctaatt tcatcaatat caaattcgtc gcggatttca 877021 ccgacaattt cctcaatgat gtcctcaacc gtcacaagcc cggcagtacc gccgtattca 877081 tcagacaaaa tggccatgtg gaccctctct ttttgcattt tgacaagcag gtcttggatc 877141 ggcgcagatt caatgacatg aatgataggg ttgacgaatt gagaaatggt ggaatcaaca 877201 gatacctcac cgctgatgca ggcggtcagc acttctttaa tgttaataac cccgataatg 877261 ttatctttat cgccctcttc cacagggtag cgggtatatt tttcaatctg aatgatgtcc 877321 atcatttcag aaatcttgat atcatgcgga aggctgacaa tttcggtccg cggaatcata 877381 atttctttcg cgagcctgtc gtcaaattca aagattttat tcacatattt aaactctgat 877441 tggttgattt caccgctttt atagctttca gacaaaatga ttcgcagctc ttcttctgag 877501 tgagccagtt cgttttctga aacggtctcc aggccaaatg ctttggtcaa taaccgtgcg 877561 gaattgttca aaagccaaat gaatgggaac gcgatgcggt aaaaccaaat cagcggtttc 877621 gcaaacagca tagacactgc ttccgccttt tggatagcga ctgttttagg tgcaagttct 877681 ccgacaacaa cgtgtaagaa cgtgataatg gcatacgcaa aaataaacga tatgacatgt 877741 gaaagggaac ctggaacgtt catttggacg aaaagcgggt gaagcagcct ttcgatcgtt 877801 gattcaccta aaacccctaa tccgatggaa gtcaatgtaa ttccgagctg acacgcagat 877861 aaatattcat caagatgcgt ggtcactttt tttacggcta ttgctgcttt atttccttcc 877921 gcgatcagct gatcgatccg tgagcctctg attctgataa tggcaaactc agatgccacg 877981 aaaaatgccg tcagggcgat taaaacagca actaaaatca aattcactat gtccaattag 878041 aaccttcact ctagcaatga gaatgaaggt aacacctcct gttagataaa atggttttaa 878101 cttaacagca gcataaatga ttggaacacg gcgagctttt caggcgggag tttgcttttc 878161 agcttgtcac gatcctcggg cttcagccgt tcaaaccgat gcaagattcc ggagatgttt 878221 tgattcatat gatcaatttc taatgccaga tttccaattt catcatcaag tttagctgaa 878281 gagggaaact ggttctccag tcgatcttta atatcggaca gggccaatcg ctgcttcttg 878341 caatctacaa taaatataag tcgtttgagt gcattttcgt cgtagtaacg gtaatttgaa 878401 caggatctgg ccggcgtaag cagaccgaga ttcgtataat aatcaactgt ccgtttcgtt 878461 actccggcga gtgccgctag ttcactgatg cgataagtct cagccccatc tatatccctc 878521 ccaaccatca cgttatagtt atgagaatag tttaatatat gaacggtgtc ttgcacaagt 878581 ttattgtttt ttttagaccg gaattggaag ttgtggaatt catcatctga ttgaagtaac 878641 ataggaagat agaattttca aatttttata tgcggaaggg acagatgaaa ttggctgggt 878701 tatcccggga agttgaagaa aacttaaata aaggatcatg gattcgcaag ctgtttgatg 878761 aaggtgcaag gctgaagaag gagttcgggg aagaccaggt atttgatttt tcactcggca 878821 acccgattgt tgaaccgcct gaagctttta agagagcgtt aatagaggaa gctgaaaaag 878881 gcagccacgg atacatacaa aaccaagggc ttcttgcagc gagagaaaaa gtcgcgcaat 878941 ttctgggctc gcgttttgaa gctgatttct cagcggagcg catcgtcatg acggtgggcg 879001 cgggaggcgc tttgaatgtt gcgttaaaaa gcatcgtaaa ccctggggaa gaggtcatta 879061 ttcttgcacc ttattttgcc gaatataagt tgtatattga gaactacggg ggaaaagccg 879121 tcagctgccc gttgacaagc cggtttgaga tcgacattga agcggtaagg caatcgatca 879181 ctccacagac gaaagggctg attctcaata caccgcataa ccccacaggc actgttctca 879241 gccagaaaaa tatagacgat ttaggcgctt tattaaaaga aatagaagag aagagcggcc 879301 agacgattta tgtgctgttt gatgaaccgt acagtcaatt aatctatgat gaagagctgg 879361 caaatccgtt tcaatcgtac catcgtgtga tattggccag ctcattcagt aaagatctcg 879421 gcatagccgg agagcggctc gggtatatcg gattggacag ccgaatgccg gatgcggacc 879481 ttttgatcaa cgcttttgtg tattgtaatc gaacgcttgg atttgtgaat gcccctgtca 879541 tgatgcagcg ggctgtggca cgaatggatg atttaagagt agacgcgagc gcttataaag 879601 agcgccggga tttaatggta gacattttaa aagaagccgg ttttgaattt gaaatgccaa 879661 agggaggttt ctttgttttt ccgaaatcgc cgattgaaga tgaagttgca ttttgcgtgc 879721 atgccgccca aaaatacaaa ttattaattg tgccgagcag cggttttgga atgagcgggc 879781 atttccgatt atccttcagt gtgccgatcg agcagattaa aaactcacgg gacattttca 879841 tttctttata taaagatttt gcttaagaag gcaaagaaaa gaaaacagtt ttcaaggctg 879901 ttttcttttt atatccgcaa aatccttcct cttccaatcc agacaggcgc agaattgaca 879961 agcaggcatg cagttaaggc tttcttcatg ataaaagtct aaaaattaaa aatcattttt 880021 ggaatgagtt gtgttacaat aaaatataca atttataatc aaactttgac ttttggaggt 880081 ggtatgatgg ggccctctgc ttaggcaaca atacaccgcg tacctcaatg ttaaggaaaa 880141 atgattatat caggaggtga ctccttatcc tttgttgaga ggatagggtt aaatggacga 880201 tattgacagt ctgattttaa ttggcgtgct cattgcttta accgcgtttt tcgttgcaag 880261 cgagtttgcg attgttagag tgaggagatc cagaatagat cagcttatca cagaaggaaa 880321 caaacgggcg atactcgcaa ggcgtgtcat tacagatttg gatgaatatt tatccgcatc 880381 ccagctaggc attacattga catcaatcgg gcttggcgta ctgggtgagc cggcctttga 880441 acggctgctg catccactgt ttgaaccgct cggcttgccg gactcggttt cacatgcagt 880501 ctcttttgca gtcgcgtacg gcttgatcac gttcctgcac gttgttgtag gtgaactggc 880561 cccgaaaacg gtcgcgattc aaaaggcaga acagctgact ttactgatag cgggcccttt 880621 gcgtttattc tatttgctcc tgtttccgtt tatttggatc ctcaatggat cggcgcggct 880681 tttatgcggg atgttcggtt tgaagcctgc gtcagaacat gatggttccc attctgagga 880741 agaactcagg atgctgttat ctgagagttt aaaaaacgga gagattaatc cgtctgaata 880801 taaatatgtg aataagattt ttgaatttga taatcggatc gccaaagaaa ttatgatacc 880861 gcggaaggaa atggctgctg tgtcaactga gatgacgatg gccgagatgc ttgaagtcat 880921 gctgaaggaa aaatacacgc gctggccagt cacagatgga gacaaagaca gtgtgctcgg 880981 tttggtcaat acgaagcatt tgttttctga tttgctgttt atgacagaag aagaacgaat 881041 gaagatgacg atccatccgt atgtgaggcc ggtcatcgaa gtgattgaaa cgatcccggt 881101 tcatgacttg ctgattaaaa tgcagcgcga gcgcattcat atggctatat tgtcggatga 881161 atacggagga acctcgggac ttgtgacgac agaggatatt cttgaggaaa ttgtcggaga 881221 gatccgagat gaatttgatg aagatgaaca gccgctgatc caaaagcttg gcgacggcca 881281 ttatgtgatg gatggaaagg ttcggatcga tcaggtgaac agccttcttg gcgcatcgat 881341 tcaagaagac gtcgatacga tcggcgggct gatattaaaa gaaaacatcg atattgaggc 881401 tggtgaatcc attcgcatcg gttcatatac gataaaggtg ctgaagatgg acggccgatt 881461 aatcaagcaa atcgatataa aagaagaagc cggcaacaca accgggatta cggcgcacca 881521 caagctgccg ctgcccgagc ctgtgatgct gaacagtgca accttgagcg agaaataagc 881581 tcaaggtttt tttatattgt gattgtccag ccgcaccaaa atgcaaaaag cgacccgcaa 881641 agtgtcagga cgatgtacaa gatgctttct tttacacgtt tggccataag gagttgaata 881701 gtttcaacgc tgaatgtgga aaaggtcgta aaggcgccaa aaaaccccgt gccaatgata 881761 agcgagaccg aagcatttgc aacgtgaagt cctgtaaata ttccgagccc gagagctccg 881821 agaatattga ctgtcagtat gccaatgggc aggctgagac ctttggtttt ggcggttatg 881881 acattgccaa gccagaagcg aagcattgcg ccaagtccgc cccctatgaa aatacccgct 881941 agtgtcattt ttcctgcagc ccctttcttt gctgaatgcc tgctatgcgc cgtcccacaa 882001 aaacaccaat cagtgcaaat atgatccctg atatcaatga ggctgccaca tataaaagag 882061 ccaatgaggg ttgtccttgc aaaagcatca ctgtttcctt agaaaacgtg gacattgttg 882121 tgaagcctcc gcaaaagccg gtgcctaaaa aagccgacag cagaggccgt tttgccccga 882181 tcataaaaaa tccggtcaaa atgcctaata gaaggctgcc tgccgcattt tccagccagg 882241 ttgccgccgg gaactgaccg gtgtgtatcc ataagtttaa tccgtatcgg aggcaggcgc 882301 caagcgcgcc tccgataaaa accgcgctat atattttcat gtttgccatc ctttatgatg 882361 aaatccgggt aatctgtaac gatgccgtcc acgcccatgg cttgtaattt tgccgctgtc 882421 ttttgattgt tgacagtcca tgcaaatatg tttaagccat ttttattgat ggagccgatc 882481 atcagacggt taagccgtgt gtgttttata ttgacatagt ttgcaaaaga gcggaaggcc 882541 ttcatctgat ttctggacag catgccaaag ttgggccttg taatgaccgc tgtcggaatc 882601 gaaggataaa gctcgcggaa cctttggacg gagcggaact gaaaggattg aacaatatta 882661 ttgatagaaa aagaaaattg ccctaatagc tgtcccacct cttcttcaat tccgacttga 882721 gacggatggc cttttagttc aattaaaagg ccgatttttt tgtggtagcg cttgagcacc 882781 gcttccaggg ttggaatacg ctctccttga aaagcgggac cgtaccagct tcctgcatcg 882841 agtttttgca attcctccaa ggtaaaatcc ttaacaaagc ccgatccgtt tgttgttcgg 882901 tcaaccctgt catcgtgtat cacaacaatc tgcctgtctt ttgtaagctg gacatccagt 882961 tcgatcatat ctgcattcat tttcaccgca aggtcaaatg cggcaatcgt attttccgga 883021 gcgtagccgg atgctccgcg atgggcaatg atgtacaagc taagtcagct cctcgtatgg 883081 gcatttctgt tattgtatca aatccatata tgcaccgcga tacaaactgg tgaatttttt 883141 ctgccatatc ggaatggtcc gggctgagga atgcgtataa ctaaaaaaag acactcagcg 883201 tatcagaaca catttcgtca gaaaattagg tctttcgaca tgttcacaac aaaatatgat 883261 cctttataat agcaaaaaag gaggcgagat catgggaaaa gggagaatca gagtggagga 883321 aagaattaaa gccgaaacgg atgctgaaat gcaaaaagca actctccttg atcagacaca 883381 aacgaaaaaa ggtaagtgac tgtccctatt gaatctggct gatagatgaa ttgagaaatg 883441 accccggcgt ttcgccgggg ttttgtgctg cataagacat ttaaatgaac atccttacga 883501 atattttagt ataataaaca attgattggg atagagggga gacagtcatg ccggattatc 883561 tgcagcagta ttttacgctt gataacatca tacaaatcgg catcagcttg gcgattttgc 883621 tggtgtttct tatacttaga aaattattca caagatattt ttttaacctg ctttttaatt 883681 tgacaaaccg gccgaaaaca gaaattttta aacaggtggt tctggcgttt gataagccgg 883741 ccagatggtt ttttgttgcc cttgggctgt ttttagcgat ccggtattca ccgtttttag 883801 atgagcaaat gccggtcatc agcaaaatat accgctcact gattgtggcg ctcttgtgtt 883861 ggggtctttg taatttgacc gcaacatcgt cgtttatctt ccataaggtg aaccagcgct 883921 tcgagcttga catggatgac attctggccc cgtttttatc caaattgctc cgttttgtga 883981 tcattgcgct cagtgtcagt gtgatcgctc aggaattcaa ttatgatgtc aacggatttg 884041 tagcgggcct tggtcttggc ggactggctt ttgcgcttgc cgcgaaggat accatcagca 884101 acttcttcgg cggtattatc attattactg aaaagccgtt tacaattggt gactgggtgg 884161 agacgtcgac agtaacagga tcagtcgagg atattacctt taggagcacg agattcagaa 884221 cagcacaggg ggcgcttgta acggtgccga actctacgct gtcgatggaa gcgatcacga 884281 actggacaag aatgaccaaa cgccagatta cgttttccat ccatgtgtcc tacgctacgc 884341 cgattgagaa ccttgaacgc tccattcatt ctctcagaac aatgctctta gagcatgagg 884401 gcgttgataa tgaaataatc atggtcaact ttgatacgtt tgccgacagc tactacaatt 884461 tattttttaa cttctataca aaaacgacgg tttgggctga aaaccttaat attagagagg 884521 atatcaacta taaaattatt gagattttag gtgcagaagg cgttcagttt gcatatcccg 884581 gccaaatggt tgttgtcaag caaaagcacg aaagcgacca attccaggtg aatctaaata 884641 aagaggaaaa ggaacgggct taaaagagag acttcgtctg acagaggcgg agtctttttc 884701 atggtaaaat aagagaaaaa ggcggtgttg agttggaaac attcaaaagt attctacatg 884761 aagcacagag aattgttgtg ctgaccggag cgggaatgag cacagaatca gggatccccg 884821 actttcgttc agcagggggc atttggacgg aggatgcctc aagaatggaa gcgatgagcc 884881 ttgattattt tttaagttat ccgcgtctgt tttggcccaa attcaaagaa ttgttccaga 884941 tgaaaatgag cggcagcttt gaaccgaatg aaggccattt gcttttagct gagctggaga 885001 agcaagggaa gcaggtcgat attttcacgc aaaacattga cggtcttcat aaaaaagcgg 885061 ggagcaggca tgtgtacgaa ctgcatggtt ctatccagac agcagcttgt ccggcatgcg 885121 gcgcccgata tgatcttccc catttgctgg agcgggaggt gccggagtgc acggcggccg 885181 gaaacaatgg ggacatttgc ggaacggtat taaaaaccga tgttgttctc tttggcgatg 885241 ccgtcatgca ctttgacacc ctttatgaaa agctggatca agcagatctt ttattggtta 885301 tcggcacgtc tctcgaagtg gctccggcta gatttgtgcc tgaggatgca agcctgattc 885361 ccggcatgaa gaaagtcatc ataaaccttg aaccaacgta ttgcgacagc ttgtttgaca 885421 tggtcatcca tcaaaaaatc ggcgagtttg cccgaagttt gggcatgaaa aagtgagccg 885481 ctttatgcgc ctcacttttt tattcatgaa caggaaccat tgtgtcctct aacactccga 885541 aggaatagcc tttttctttt aatttattga ttagtaccgg cagcgcattt acagtagcag 885601 gaagatcatg catgagaatt acatttgggc ggcttgaaga gctgtgttcc atattctcaa 885661 gctgctgtaa tacggcggtc acatactgtg aattccggta tttccagtcc atgctgtcga 885721 tcgtccaatc ccagtacaca aacccatctt tctccagatt gcgaatttgt gaggcggtta 885781 gtgacggctt gcttccgtat ggcgttctga caagatcggt tttatatcct gtaatgtcct 885841 gcagcgtgtc acgcgcctcc tgcatttctt ttagcggaga tgtcggtgtt tgatagaaca 885901 atctgttatt gtgggtaacg ccatgtaaac cgagtgcgtg gccttccttt tctgctcttt 885961 tcacagcctg cttgaattcg ttcatccgcg gtgacagcat aaaaaacgtc gcttttacat 886021 cagcgctttt cagtacgtcg agcaagcggg ttgtaacggc tgaagggccg tcgtcgaagg 886081 ttaagtaaac cgttttatct cccatgttct gctttgtctg cagatgtttt atcaggagat 886141 cgggggagtc gtttttcagc ttaaggcttt ccttctcatc tcgaagctgg ccgtttgttg 886201 tgacagtgac ttcctttgct ttcgttgaac tgttggaata acccaaaatc accataagca 886261 aaagcagcac acataaaact gctaaacttg caaatttaaa agcaagcgaa actgcagaag 886321 gagaagcctc tcctctcgtt tgtcgcataa caatctctcc attggcataa aatctctaca 886381 taatgctgta cagcaggcag cttatgaaga tgccttatgt ttacaaccta tgtattacca 886441 gtcaagtata caggaataaa actggaaagc acatagaaaa tttgtcgaaa tgtcagattt 886501 taaggaaaaa ataaactcct ttccgctata gatctcttga tctttctgtt tttcagcttg 886561 tccaatatgg tagaattagt gataatgaca gcttgaatga catcagggac atctcgaaaa 886621 gggagggctt ttatgaaggt tttagtcaat ggccggctga ttgggcgcag tgaagcatca 886681 atcgatttgg aagatcgcgg ttatcagttt ggtgacggca tctatgaagt gatcagggtg 886741 tacaaaggag tattgttcgg cttacgtgag catgcagagc gttttttcag aagtgctgct 886801 gaaatcggaa tttcactgcc attcagtata gaagatctcg agtgggacct gcaaaagctt 886861 gtacaggaaa atgcggtcag tgagggagcg gtatacattc agacaacaag aggtgtggcc 886921 ccgcgaaaac accagtatga agccggcctc gagccgcaga ctactgccta tacgtttacg 886981 gtgaaaaaac cggagcaaga gcaggcatac ggagtggcgg ccattacaga tgaggatctt 887041 cgctggttaa gatgtgatat caaaagtctg aatttactgt ataatgtcat gacgaagcaa 887101 agggcctatg aagccggagc atttgaagcc attttactta gggacggcgt tgttacggag 887161 ggtacatcct ctaacgttta tgccgttatc aacggcacag tgcgaacaca tccggctaat 887221 cggctcattc tcaatggaat tacacggatg aatattttag gactgattga gaagaatggg 887281 atcaaactgg atgagactcc tgtcagtgaa gaagagttga aacaggcgga agagatcttt 887341 atttcgtcaa cgacggcaga aattattccg gtcgtgacgc tcgatggaca atcgatcgga 887401 agcgggaaac ccggaccggt gaccaaacag cttcaggctg cttttcaaga aagcattcaa 887461 caggctgcta gcatttcata aatgaacgaa gaaaagagcc cgctttttac agcggggctc 887521 tttttatttt ttaacaaatc caatcaaaat ggagatcatt ggcgatatat agaggaagaa 887581 cgtaaatggg atgtagtcta tgactggaac accaagtgcg ctcgccataa atgcgccgct 887641 gacgccccaa ggaatcaatg ggttaattaa tgttccgccg tcctctaatg atcttgtcag 887701 aaattttcgc tggatgtttc gtttgtcata taaagattta aatgattgtc ccggtattaa 887761 tatcgataaa tactgttcgc ccgttgccaa gttgacgccg atgcttgagc agacagttgc 887821 tgcaacaaga cggccttttg agcggatgcc tttcatgacg ccttccaata gtgcagaaat 887881 caatccgatt ttctccatca atccgccgag tgcaaaagca atcataatga gagagacaga 887941 gcccatcatg gattgcagtc cgcctctgtt aataatttta gcggctgcct cattgtcagt 888001 ttcgaaagtt gtgccatttt gtaaagctgt cataaacgcc tgcaggctgc tgtagggtac 888061 aaaaatagca gtcaaaattc ccgaggaaat aattccggca gtcagaacgg ggattactga 888121 tacccgtttc attgccagca aaacgactaa gagcggagaa agaagggccc acggtgtcac 888181 gtttgcagca tcttttattc cggttatgac ctgctgaata ttatcggttg aagcagcgtc 888241 cgctgacact gatgaaccga gaaagtaaaa cagaacgaca gtgatgagca aagctggaat 888301 ggttgtgccc atcatatggc gaatgtgttc aaagattggt atttcgccta ttccggctgc 888361 aaagttggtt gtgtccgaca tcggcgacat tttatcccca aaacaagcgc cgcatatgac 888421 tgcgcctgct gtccattcaa gcggaacgcc agccgcgctc gccacgccga tcagcgctac 888481 tccgattgtg cttacagttg tcagacttga gccaacaagt gtgctgatga tcatacatga 888541 aaacaaagca gtcaacagaa ggtggcttgg ttcaataaag gatagggcat aaactgtcat 888601 agtcggtatt gcgccgctgt acatccaggc gccgattaag atgccgatca gcgctagaac 888661 aataatcggc tgtacgccgt ttttgatccc gtctacaatc cctttttcaa tgctcttcca 888721 gggaaatcca aaccataaag ctgctgctga aagcatgaca acacttaaaa acagcgggat 888781 atgaggttct acatgaagca agaataagca agaaataata atgcacaaca tgaatataaa 888841 taaaccgacg gctaacggaa acgtcagctt tttttgagaa tccaaaataa caccccatat 888901 ttatctttaa tgcttttgtg cttttgggca cgaaagcatt ataacagaaa aaaacgaaaa 888961 tctatgtttt ttcacaatta tgaatataaa agaagtgagc acagggcgtg ctcactttac 889021 aatcaggacg ggtatatccg atttcgctga aagcttttca cttacacttc cgaatattag 889081 ctttttcagc ctgttttggt ctctgcttcc ggttacgatc atatcggcag aaatgcggtt 889141 tgcatgctcg ataattgatt cagccggatc gccttctaat atatcgatat ctccatctgc 889201 ctgctgttca ttcagcatca ttctggcttc ggcgatgact tcttccgtac ggtcttcata 889261 gatcattggc tcaggtgatg ttacatccga tatcagcgga tcaggaacac ttgtcatgcc 889321 tccgctgata tagcttgcct cagctgcggg tctgggcggg tcgatgacgg tctgattgtc 889381 tttcatatca tgtgaatggg cgacggtaat agcggcattt acggttttag caagatcaat 889441 ggctgtcaga agcgctttct tactattttc acttccgtca aacgcaacaa tgatacggtc 889501 agcatggaac atccttctca ccctttcaaa gcgtcttaca acactactac ccgaatttga 889561 gcacaattaa ccttttccta ttcaagtaat gattgacaat aaaaggtttt gtttatatga 889621 tgataaaaag atgaaatcag aatggaagga gggtttgcta tgccaaggaa tttgcgtgtt 889681 tatcaaacag tttcatattg gcgcggcaaa ccttttgttc tgttttcgtg aacggttttt 889741 taggtcggac cgcgcgctga aaagcgctgt gcgtaacata tcggttaaaa aaggcatgga 889801 gctgacgctt catgcctttt ttatatacaa aatctaagga aagacaggtg tatgggatgt 889861 gaagacaaat acagaggcga gggcagttcg tgccaaactg gatgaaaaaa gctgcaagga 889921 aaaaatagaa ggcggctgat gaggagatgg ggatagatgt tttcagtttt gaaaaagctt 889981 ggctggtttt ttaaggcgta ctggctgcgc tatacgattg cgattgtcct tttattagca 890041 gtcaatgtca ttgaaatgtt tccgcctaag ctcttgggga acgccataga tgatatgaaa 890101 gcaggggcat ttactgcgga agggctgctg ttttatatcg gtatcttttt tgtgctgacg 890161 gcggccgtgt atatcatgtc ttatttttgg atgcatcagc tgtttggcgg agcgaatctg 890221 atggagaaaa ttcttcgtac gaagctgatg gggcatttgc tgactatgtc gccgccgttt 890281 tatgaaaaaa accgaacagg cgatttaatg gcacgaggga caaatgatct tcaggccgtc 890341 agtttaacca cagggtttgg catcttgacg ttagttgatt ctacgatgtt tatgatgacg 890401 atctttttga caatggggtt tttgatcagc tggaagctga cctttgccgc cattatcccg 890461 cttccagtca tggcgattgc aatcagtcta tatggaagta aaattcatga gcggtttact 890521 gaggcccaaa acgcgttcgg ggcgctgaat gacagagtgc tggaatctgt ttcaggcgtg 890581 cgggtgattc gcgcgtatgt tcaggaaaca aacgatgttc gccggtttaa tgaaatgacc 890641 gctgatgttt atcagaaaaa tatgaaagtg gcttttattg attcactgtt tgagccgacg 890701 gtaaaactgc ttgtcggcgc aagctatctg attgggctcg gctacggagc gtttcttgta 890761 ttccggaacg agctgacgct tggagagtta gtgtccttta acgtttatct cggcatgatg 890821 atttggccga tgtttgcaat cggtgaactc attaatgtga tgcagcgcgg caatgcgtca 890881 ttagatcggg taaatgaaac tctttcttat gaaacggatg tgacagatcc aaaacagccc 890941 gctgatctta aagagcctgg agatatcgtt ttcagtcatg tcagctttac atatccaagc 891001 tcaacaagtg acaatcttca ggatatttca tttacggtgc gaaaagggca gactgtcggg 891061 attgcaggta aaaccgggag cggaaaaacg acaattatta agcagctttt gcgccagtat 891121 cctccaggtg aagggagcat tacattttca ggtgtaccga ttcagcaaat ccctcttgac 891181 cgtctccgcg gatggatcgg atatgtgcct caggatcatt tactgttttc acggactgta 891241 aaagaaaata ttttatacgg aaaacaggat gcaactgata aagaggttca gcaagccatt 891301 gccgaagcac attttgaaaa agatttgcac atgcttccgt ccggtctgga gacaatggtc 891361 ggtgaaaaag gcgtggcact gtcaggcggg cagaaacaaa gaatttcgat cgcgagagca 891421 ctcatggcga atccggaaat cttgattctg gatgattcac tttccgctgt agatgccaaa 891481 acagaggctg caattatcaa gaacatcaga gaaaaccgca aaggaaaaac gacatttatt 891541 ttgacacacc gattatccgc ggtagagcac gctgacctga tccttgtgat ggacggcggc 891601 gtcattgctg agagaggcac gcatcaagaa ctgctggcca ataatgggtg gtaccgggaa 891661 caatatgaaa gacagcagct gttcactgcg gaagaagggg gagcaggggc atgaaaatag 891721 gaaaaacgtt atggagatac gcacttcttt atcgaaaatt gctgatcaca gccgtccttt 891781 tgctaactgt tgccgtcggt gcagaactga ctgggccctt tattggcaaa aaaatgatag 891841 acgaccatat cctcggcatt gagaaaacat ggtatgaagc tgcggaaaaa gataaaaatg 891901 ccgttcagtt tcacggcgtc tcatatgtca gagaggaccg attgcaggag cctgtttcaa 891961 aagcaaaaga agcgcatatt tatcaagtgg gaatggcgtt ctattttgtt gatcaggctg 892021 tcagcttcga cgggaataga acggtttctg acgggaagct gacgatcaca aacggagaca 892081 agagccgggc atatgctgcc gaaaagctga ctaagcagga acttttccag ttctatcagc 892141 cggaaataaa gggaatggtg ttactgatct gcctgtatgg gggcttgctt gtgttttcgg 892201 tattctttca atacggacag cattatctgc tgcagatgag cgccaatcgg attattcaaa 892261 agatgaggca ggacgtgttt tcgcacatac agaaaatgcc gattcgctat tttgacaacc 892321 ttccggccgg aaaagtcgtt gcgcggatta ccaatgatac ggaggctatt agggatttat 892381 atgtcacagt gctttcaaca tttgtgacaa gcggaatcta tatgttcggg atattcacgg 892441 ctttgtttct gcttgatgtg aagcttgcgt ttgtatgtct ggcaattgtg ccgattatct 892501 ggctgtggtc ggtcatatac cggagatatg cgtcatatta caaccaaaaa atccgctcga 892561 tcaacagtga cattaacgca aaaatgaatg agtcaattca aggcatgacc attattcagg 892621 ctttccgcca tcaaaaggaa acaatgagag aatttgagga attaaatgaa tcacattttt 892681 atttccaaaa caggatgctg aatttaaact ccttaatgtc ccataatctg gtcaatgtca 892741 tccgcaatct tgcgttcgtc tgtctgatct ggcattttgg cggtgcgagc ctgaatgcgg 892801 cggggattgt ttctatcggt gtgctgtacg cgtttgtcga ttatttgaac cggttatttc 892861 agccgatcac aggcatcgtc aatcagtttt caaagctgga gcttgcaagg gtctccgccg 892921 ggcgtgtttt tgaactgctt gaagaaaaga atacggaaga agcgggtgaa ccggcgaagg 892981 agcgcgcgct ggggcgggtt gaatttcgtg atgtgtcatt tgcgtatcaa gaaggtgaag 893041 aggtattaaa gcatatttcc tttactgcgc aaaaaggcga aaccgtagcg ctcgtcggcc 893101 ataccggatc aggaaaaagc tcgattttga atcttctgtt tcgtttttat gatgcgcaaa 893161 aaggtgatgt cttaattgat ggaaaaagca tttacaacat gtcaagacag gaactcagat 893221 cccatatggg tattgtgctt caggacccgt acttattctc gggcacaatc ggatctaacg 893281 taagtctgga tgacgaaaga atgactgaag aagaaataaa aaatgcactg cggcaagtcg 893341 gtgctgagcc tcttcttaag aagcttccga agggcattaa tgagcccgtg attgaaaaag 893401 gcagcacgct atcctctgga gagcggcagt taatttcttt cgctagagct ttggcgtttg 893461 atcccgcgat cttgatttta gatgaggcaa cggcgcatat tgatacagag acagaggccg 893521 tgatccagaa ggcgcttgat gtcgtcaaac aaggacgcac caccttcgtc atcgctcacc 893581 ggctttcaac aatcagaaat gctgatcaga ttttggttct tgataaagga gaaattgttg 893641 agagagggaa ccacgaggaa ctgatggcat tagaaggcca atattatcaa atgtatgaac 893701 tgcaaaaggg acagaaacat tccattgcat aacgctcaaa aacccaaaac aatcgtgttt 893761 tgggtttttg gtttatgtag tcaataagcc agtccgacac ggtttccgac atactcacct 893821 gtaacgagct cacgatataa aaagtccgca gtatcgccga ccgaaatgct tgtgccgccc 893881 tcaggcaaaa cgttacgctc cgtacgataa acgccggttg ctgttccgtc cgggaggtaa 893941 gtggggcaga tgattgtcca gtctaatgat gattctttaa gcatttcgta tacttttgca 894001 tgctccttgg ctgcgcgggt ctgctttcgt ttcgattcat ttgtttcaaa ccggtatttt 894061 cccggttcat atcgggaatc taggatccct gcggtgccga tcgtaataag ccgtttgata 894121 tgctgttcct ccataacgga gagaatgtgt gccatagcag ttgacaaggt atcatcacca 894181 tctgtgccta gacagctgat cacgatttca gcattctcca ttattttttt cacatcttct 894241 aagcggcggg cgttccccat gacagttctg tcttttgaaa ggggaagatc agcatgttga 894301 gatctgatca gagcgaaaat atcaaatctt tcatctgctg cagcttgtgt taaaaaggct 894361 tgtccgacgc ggccgctggc tcctaataaa gcgattttca ttaaaaaacc tcctcgcctt 894421 tcattataaa aggatgttct cagtttgaac agcgcgggaa agaatacctg tacaaataaa 894481 cagaacgatg ggaaacatat tcatgaatca tggatacact tacgaattga accagctccc 894541 aattcacaat ggtgatgaat gacaccccga ttccctccct ttttttctag gatatgtgga 894601 gcaggaaaaa agggtgacaa aataaagaga gcgcggaaac cgcgccctct atagccatat 894661 attgaattgt tattgaactc tgccgcccat ttgctgctga gcgaaagata ctaaacgttt 894721 tgtgatttct cctccgacag aaccgttagc gcgagaagtt gtgtccgctc caaggttaac 894781 gccgaattca gaagcgattt caagtttcat ttgatcgata gcctgagctg cgccaggaac 894841 tagtaagtca tttgaagagt tttggttagc catgtgtaaa atctcctttt tatttagtat 894901 ggttgggtta actggagttg caccaatctg tgaacccttc tcgggtgtca ctgccgcctc 894961 ggcgtaaccc aatgctttgc cggcttgtta ctacgtatta tgttaaaatg gccggaaaat 895021 catgcggaga attgtgtggt aaatcttgag aaataaaaaa agcttagccg tttaggctaa 895081 gctagtcata aatatgaaaa agcatcagtt catgtatctc gtttgtaaga gcaggctcgt 895141 cagcgcgggc gggaaacaag tctccccatt caatctcacc gctcttatga tagatgcctt 895201 cataatgggt ccctttataa taaaatgaaa ttttccatcc gggcagcttt tcttttggga 895261 acaaaggttt ccagctgaaa tgagaaatca ttacggccac gctccttaca tttggtatca 895321 attgacctaa ataaaaacgg cttatgttca ttgtatcatt gtttcagaac atcattgaag 895381 aggcctaaat atgcagtttg tcccagcttt ggataaagat aagcccgctt tattaaaaaa 895441 gcggacaggt tacgaaggcc acaatgcttc cggagatgtg attgccttct cagataaata 895501 tgacgcgtat tcaaaacttc ttcgttttgt aagagaatca acatgatgca aatttggatg 895561 agaaaaaatg cttcggcccg ggcgcgaatt cgcttcaaac atccatactt taccgttctg 895621 atcaatgcca aaatcgaaac caatctcccc gataaatccc tcgatatgat catgaaggac 895681 atggcttgca gtcagtgccg ctgcagaaag ctttttaatg acctcaactc tttcagcggg 895741 atcatcgtat acttccgcaa gtgtctttac agtgccgccg ttagaaagat gtgttgtaat 895801 gctgttcttt ccggaaattt ttacggcgat tgctgtcact gtccattttc cttttctgtt 895861 tttattggta tggacacgga aatccgctgg tttgccttga aattcgatga gatcaacacc 895921 ttgctgaatg agaaagtcgg acgggttgtg atgtttttga aattctgcaa ggaatgaggc 895981 ggcatcggaa taatcaattg atgtaaaagt tttggcgtca ttcgtatgct ttaccgtcag 896041 gccgccatct gttcttgtca gctgataaat gccggtgccg agtgctccat ttgccggttt 896101 gatatagact tttttgtatg cgccacagag ctcatctatc agctccacag acggtgtcag 896161 ctcggatcta ggcaaaaagg gtgccgttct tggatctttt tcgagcaatt gatgaacgtt 896221 ccatttattg aaaaacgttt tattaaacca tgggatctga tattcatcga tcagcctctt 896281 ttttgtatgt tgcaagagaa gtgaatcttc aatttttcgg ttcggcaaac ggtcataaac 896341 gacgttcggc aatggaacga tttttttctc ccagccgttt tccctgtaaa ggaggccttc 896401 aatcgtgcct tcctcccaat tgatttggtg cgcgccaaaa acgaagcagt agcccccggc 896461 ttgctcgtgt aacgtgacaa gtttagaaaa aaagagggaa cgatccttaa atgggcgttc 896521 aagagataca gtaaaccctg ccgtaaagat gccgactaac ggcccgatat gcactgtatg 896581 atcatgaatc agtatatctg ccctgcttcg gtggggaagc aaaagctcat gaaacagatt 896641 ttcagagaga agcacggttt gttccagatg ccgtctgtaa gcaacgtggc atctgacaac 896701 cttcgttccg aatgcggcat gcaaaagtcc gtcttgcttc agcgaagagg gcagaaacag 896761 ggtgttttca ctggttttgt ctatgccgat caaaaaccgt ttaggattca cgcggaagaa 896821 ctcctttctg gctttgctca gaaaacagat attggcagcg ttttagggga caagtgtaca 896881 gctgttcttt ttgctcggga gagacacgca ggattgactt cctgcctggt ttggaattga 896941 tatctaaaat ccaaattctc ccgtcctttg caagacatat atcaagaccg agttcaaaca 897001 acggcccata gcgctcgtca agataatacg gaaccgattg ggtaattgaa aacacatcat 897061 ctagtaaaac cacttgctgt tttttcggta tatcttcaaa ccaggagtca aatgtcagcg 897121 catcagatcc gcctgacaaa ttggccagca gcccgtgttt gtatccgcgt cttactgcct 897181 ttccgactgt attccattca cctgcttcgt ttttttccat aaacagacga atatcacaag 897241 ggtattgttc cttatcttga atgtttaagt aaggctgaag caaatattga tgctgaagca 897301 cttttttgca ccatgtttta aaagaagtct ggttggaaaa cgtttttgtc tgcttatcct 897361 ttccgatgtg ataagtagca gtgatgtttt tcttgcccag cttcaaaaga atcacgcctc 897421 tgcctcccgc gccgaatgcc ggtttaagga tgcaggcttt ttctttggat aaaaaggagt 897481 gaatttgttc gtagcggctc acctttatcg tttcgggaat atagggattg attacagagt 897541 gctgctgcaa atcgtgaagg acggtccact tatcgggaag accccgcccg ataaattccg 897601 ttttcggata ttttttgagc cactcaacga ttggttttgc tttttgggaa tgtgaatcct 897661 tgccgtaaaa acagcgatca taaatataat ctggaatcgc catttcagtt tcgttccatg 897721 tgctgctggc cgaatgatag accgatgctt tgacacgcaa agtgtcaggt gaaatatcaa 897781 atggtgtaaa ccggatgaaa cgtatgccga attcgggtgc tcttttggcc agttctgcgg 897841 aataatccgc ttcatgctgg cgggataagg acataaaacc gagtgttatc atggtgagac 897901 tccccctttt attcaaaagc tgccggcggg tgtccgcagc tttacactaa atacatgtaa 897961 gacgaacgca gctgacggta ttctacttta cagaatacga ttctccacct tgccctattc 898021 caaaagaaca agctgatttt ctaagaacag gaatttgtct cctcgtttgc taagtgattg 898081 catgagcctc tataatacgt ataggtacat aatctatatg aaaaaagctg aagcacagat 898141 ggaggaagat gaataggaat gggtattgca ggaaccttta tttttatgat cgtgatcggc 898201 gctgccattg gagcggtgac caatcattta gcaattcaaa tgctgtttag gccgtataaa 898261 gcgtactatt tgtttgggaa acgagttcct tttacgcccg ggctgattcc aagacggcga 898321 gatgaacttg caaaacaaat gggactgatg gtagtcaatc atctcttaac ccctgaaggc 898381 attaaaaagc ggctcgtctc tgatgcagcc aaaacgcagg ctcttcgagt gggggaacag 898441 ctgattcaaa agctgtcact ttctgaagtg acagtaaaag aagcgcttga aaaagccggg 898501 atgaagcgcc ccgaaaaagc tgctgatgca tggatcagca gctggaccga tgataagctg 898561 catgagcttt tccgccaata cggggaccaa tcgttaaaag agctggtgcc tatagaggtg 898621 caggaaaagc ttgaggaaaa aattccgatg atttcaggat atatattgtc acggagtgtc 898681 cgttattttg aaagtgatga aggaaaaatc cgtcttggca atatgattga tgacttttta 898741 aaagagcgcg gcatgcttgg aagcatggtg caattgtttc ttggcaattc aagccttgcg 898801 gatcgcgtgc tgccggagct gctgaaattc ttgcgcaatg aggaaacaaa taaattgctt 898861 tctgatctct taaaaaacga atggggcaag ctgagggagt atacgtttaa tgaagcagat 898921 gaaaaatgga atgcaaaggc gctcattttc agtttgaaac gaagagtgct gcaagcattt 898981 tcgactgccc ctttcttcaa caatacgatt ggcacgctta ccgtccgcta tgaatctgag 899041 ctgacccagc aaatgctgcc ggcactatta gacaaattgc ttgaaggtat ttcgtccaac 899101 cttgaaagtg tcttaaaacg gttgcgtctt gaggaaatcg tcaaggagca ggtggatcag 899161 ttcccggtgg agcgtcttga agaaatggtg ctgtccattt caaaaaaaga atttaaaatg 899221 attacctatt tggggggcct tctcggcgga attataggcg cgattcaagc attgtttgtc 899281 atcctttttt aagaagaaat ggtttttgat taatgaaagg agctccatag tctgttatag 899341 tggagtggta tgtcaaacgg caatgatgaa aggagctatt tacaatggct gttaattttt 899401 atgatgtagc gtatgatctg gaaaatgcat tacgcgggag cgaagaattc acccgtttaa 899461 aaaaccttta cgacgaagtt aacgcagatg aatcagcgaa gcgcatgttc gaaaacttcc 899521 gtgatgtaca gcttagactc cagcaaaaac aaatggcagg agaagagatt acacaagaag 899581 aagtgacgca ggctcaaaaa acagttgcgc ttgtacagca gcacgaaaaa atttctcagc 899641 tgatggaagc ggagcagcgc atgagcatgc tgattggtga attgaacaaa atcattatga 899701 agcctttaga agagctttac ggcagtgttg aaggctaata agcaaaatcc cttcttggat 899761 aagaagggat tttttattca ctcagcaaac ttggaaatcc aatgaatctt ttacctctcc 899821 attgatgatg actgataatg tatgaattcc tttgtaatgc tttctggtgg ttaaatcctt 899881 aaaggattgg attcttgtgt atgacttcgt ttcgtttttt cgtatatttg tttctgttat 899941 tttaaatact ttctgatgac gctggcctct tgcttttaca aaatcaattg cgtactcaat 900001 tcttactttt tgatccctgt ctgaatgaat atagaaagaa aattcaaggc tttcgccaat 900061 aactatacgt ttgggctggc atgttaaatc atgtagttgt atcgaatcag cattttcata 900121 accaaaaagc gctaaggcct gtttatcacc cttttttaat aaggtccgat aggcgtgttt 900181 gataatccag tctgtatggg gatgtgttcc gtaccattga tctgcgactt ttctcagtaa 900241 atgaggatgc gtttttgata tatcattaag gttgttggcc acgctttttc ttacatataa 900301 agactcgtcc tgcatcagct tctcaaggat cggcaatacg ggggaagggt ccgatttcaa 900361 agccggtatc gattttcccc atggcaggcg gggcctgctg ccttcgctcg caagtcttct 900421 cacgtgttca tttttatgct cagaccatgc aagcaattgt gcaatcatct tttcttgatc 900481 taacagcaaa aaaggcctta cagcaaattc tgaggtcgaa tattgcgtaa aggattccaa 900541 tgcctttatt gattcttccc aatgcgctaa cccgtactgt tccacataat ctggaaataa 900601 aattccgctg agtcctttaa aatgaggggc tgtatcccgt aaaattgtga gcgcttcaac 900661 gtattgtttt ggcaaagttt cgtataaaga aactgtcacg cggcgcatcc gctcttttaa 900721 agtgagttca ggccagtcct ccagccgtaa tgtatccaag aatctgtttt tgttaaaatc 900781 aggataggat gaccttacat gatggatcaa ctgagatatc agttcttcat tatatatttc 900841 ttttaaatca gccatataaa caccgctttt tcgtttatta tttatattgt atgggaatgt 900901 acgttctgga tcaagtgtat agtcctaaaa attaacaact gatcctacca cggatataca 900961 aaagttggtt acttttttta gttaaaaaaa cccttgtcat cggaaaggaa aactgagata 901021 ataacattga aagcgcctac acttacctat ttcaaatgga tacggtcgca tatcatgccg 901081 ttatatagag gggataagca acagagagta agtgttcgga gcgcatcatt ggtcaaacaa 901141 ggggttcctg atacatgatt tttcgtaaat cgaaataacg atattaggga gaatggctgc 901201 ttcgatcgta tcctatcaac aagccataca taaagtctgc tgagccaggc tttttttgct 901261 ttaagaaaag gttgttctaa acacagagac agggtcatat cctatacaca agtacagtca 901321 tcaaggaggg ggacatctct gtgtcaaaac aattgcttgc cttaaatata gatggagcgc 901381 tgcttcggtc gaacgggaag attcatcagg caacgaaaga cgcgattgaa tatgtaaaga 901441 aaaaagggat ttacgtcaca cttgtgacca accgtcattt tcgctcagca cagaaaatag 901501 cgaaatcgct aaagcttgat gccaagctga tcacccatag cggggcatat atcgctgaga 901561 aaattgacgc cccgtttttt gaaaaaagaa tttctgatga tcataccttt aacattgttc 901621 aagtgctgga gagctatcaa tgcaatattc ggcttcttca cgaaaagtat tccatcggaa 901681 acaagaaaaa ggtgaattcg aatttattag ggaaagcact cattcatccg tctgacccga 901741 tcttttatcc agtccagttc gttgaatcat taagcgatct cctcatggat gagccggtga 901801 gtgcacccgt catcgaggtg tacacggagc acgacattca gcatgacatt acagaaacga 901861 ttacaaaagc cttccctgcg gtggacgtga ttcgcgtaaa cgatgagaaa ctgaatatcg 901921 tcccgaaggg tgtctcgaag gaagcgggtt tggccctcgt cgcttcagag ctgggcctga 901981 gtatggatga tgtcgtggcc attgggcatc agtatgacga tctgccgatg atcgaacttg 902041 ccggtcttgg ggtagcgatg gggaatgccg ttccggaaat taagagaaag gcagattggg 902101 ttacaaggtc caatgacgag caaggtgtcg cttatatgat gaaggaatat ttccgaatgc 902161 agcagcgaaa aggatttctt gataagttcc acatgaaacg tgtgtaaaaa agccgctcgc 902221 gccctgacag gtgcggcggc ttttttgccg gattgatttt agcagtttat ttctgtacac 902281 taaagaaagt tttgaatctg ataaattagg tgatgaagtt gcaaattaaa atagaaggca 902341 tacatgatga ccgcctgcat cggcctctgc aaaatattgc aaatttgttt tatgaagagt 902401 gcgagcttgc gtatggcgga gaggagcccg cagattttgt catttcttta gcgttgtcac 902461 aaacggatga gcatgtgacg gtttctggag aagtgaaggg tactggcata aaggaacagc 902521 atacaaaatt cttttctcca gacatgactg aaaaagaagc ttttaagcaa gtgaaaaaca 902581 caatttctta tgtgtatctc aatcttcttc aggcgcatac gggcattacg cagaagtggg 902641 gaatcctcac aggaatccgg cccacaaagc tgcttcataa aaaactgcaa agcggaatgt 902701 ccaaggagca agcgcatgct gagttgaaaa aagactattt aattcatgat gaaaaaatca 902761 tgctaatgca ggaaattgtt gaccgtcagc tggcggcagt gccggatttg taccgagtaa 902821 aggatgaagt cagcatttat atcggcattc cgttctgccc gacaaaatgc gcgtattgca 902881 cattccctgc gtacgctatc caaggacagg cgggcagagt cggctcattc ctatggggac 902941 tgcattacga aatgcagaaa atcggtgaat ggctgaagga gcatgatgtt aaggttacaa 903001 ccatttactt tggcggcggg acgccgacaa gcattacagc ggaggagatg gatctgctgt 903061 atgaagaaat ggtccgctcc ttcccggatg tgaaaaacat tcgtgagatt acggtggagg 903121 ccggtcgtcc tgacacgatt acagaagaaa aactcgccgt tttaaacaaa tatgacattg 903181 atcggatcag catcaatccg caatcctacg aaaacgaaac gctaaaggcg atcgggcggc 903241 accatacggt tgaagagacc attgagaaat atcatctgtc acgccagcac ggcatgaata 903301 atattaacat ggacttgatt attggtttgc ctggggaagg cgtgaaggag ttcaggcaca 903361 gtctttcaga aacagaaaaa ctgatgccgg aatcccttac cgttcatact ctttcattta 903421 aacgggcgtc agaaatgacg agaaacaagc ataagtacaa agttgccggc agggaagagg 903481 tttctcaaat gatggaagac gcggtagcct ggacgaaaga gcatgggtac gtgccttatt 903541 atttataccg ccagaaaaac attcttggaa accttgaaaa cgtcggatac tctttgccgg 903601 gacaagaaag catctacaac attatgatta tggaagaggt gcagacgatt attggcatcg 903661 gctgcggcgc tgctagtaaa tttattgatc gggatacagg gaaaattacg cattttgcga 903721 atccgaaaga tccgaaatcg tacaatgagc gcttcgagca ctacacggac gaaaaaatca 903781 aatatttaga gcagattttt gaaaaaacga caaagcagca ctgattacag tgctgctttt 903841 tttatccctg tttttttgcg ggctgaacct caggcttcca tttaaatacc ttgttcagca 903901 agcggtaaat tcgttttgat tcctttgtga caagcggtcc caaaatcgcc agaatgagga 903961 catataatgc ggcaaacggc tttaatgtgg ccgacagtcc gccggctatc ccgagattcg 904021 caacgataat cgaaaattct ccccgcgata cgatcgtcag cccgatattc gatgaagcct 904081 tatgagaaag ccctgcgcgt cgtcctgcca ccattccggc gataaaattt cccagaatgg 904141 tcaaaatcac tgcacccaac gcaagccaaa ccgcttcacc aagcgaaaac ggatcgatgc 904201 tgaggccgaa gctgaaaaag aacatcgcac cgaagaagtc gcgaaacgga acaacgaggt 904261 gttcaatcct atcggaatgc tctgtttctg aaaagaccaa accgagcagc agcgcgccga 904321 ttgcttctgc tacatgaatc gtctctgaaa aaccggcgat aaaaaagagt gctgcgaaaa 904381 tgacgataat aaacacttcg tttgagcgaa tgtccaacag tttgttcaac agcggcggga 904441 gttttcttgc tgcgataaaa aacagcagca tataaccgaa ggcgatcaaa atggacaaga 904501 gtgcactccc tacggatgtc gcatcaccta gtataaggcc ggaaacaacg gacagatata 904561 cggcaaggaa aatatcttca aacatgatga tgccgagaat caattcggtt tccgggttgg 904621 cggttctttt taaatcaacg agcacttttg cgacaatcgc acttgacgag attgtgatga 904681 cgcctgcgag gatgaggact tccagaaagg aaaatccggt gataaacccg taaagcagtc 904741 cgaggctgaa gttaatcaaa atataaatcg tcccgccgac cgcgattgat tttcctgatt 904801 tgattaactt cccgacagag aattcgagtc cgagatagaa gaggaggaac agtacgccca 904861 ttcgcccgaa aaactcgatg atttcactgc tttgaataaa tgttagatca ataatcccca 904921 ttttcggcgc gtgcggtcca acaagcattc ccagcacaat cagaaacgga ataatcgaaa 904981 atttaatttt attggcgatc acactggcga ttgccacaag cacaagtgca gttccgactt 905041 caaatacaag atggtccatc ggggctcaca cgccctctcc agaaagaaaa tcgtgaatca 905101 gtttcttcag atgctttctc tcacctgaga ggacaagggt gtcattttct tcaataatcg 905161 aatccgctcc gggatttagg agcttttcct ggttgtgttt gataatcgca ataacagtga 905221 catcgtaatt ctggcgaaca tcaagctcac cgagtgtgcg tccgatcgat ttggcgcctt 905281 tttcgacctt aaaccattca ataataagat cgctgaaggc catttcgatg gactccagag 905341 cttgcggttt atagaccatg cccccgagaa tagctgcaat ttgccttgct tcagaatcat 905401 ccaatgaaat atttgaaaga agctcatccg ggtcccggtc attaaaccgg taaatttccc 905461 ttcttccgtc atcatgaatg ataatcgtca ttttttcgtg gcttcttgtt tcgatttcaa 905521 actttttgcc gatgcccggc agatcgtttt ctttaatatt caatgaaaat ccctccgaat 905581 gtagtgttgg cagtatgggg tgagttacaa ataaaacttg agcaaattat attcggaggt 905641 aattagactg gtatttgaca gggacggcca aagccttttc cagcctgttt atcagcggtt 905701 cgtcaagtgg tttgacagag agctgcctga cagactgcgc cagcgggctg tactctttga 905761 tcagctcagc cgggtgcatg ctgcccggcg atggcgtttt tgccgattgt gtttcctgcg 905821 gatatgaaga cataggcaca tagctgtcag tgcttgcttc aaactgggaa ggcagaacca 905881 cgtccgaagg gggaaagtac accataaata aacttaacag aaaactgatc agcaatttat 905941 ccatgttcct ttcctccctt ctcatcaaga tatcccttct ttttcactat ataaaacttt 906001 atgtttccat tcaaacaata tgcatttttc agtatctatt gaccttgaaa aataaaaagg 906061 tttatttggg gatggcgggg aatgtatagg agaaagaaaa aagtaagcgc atacatggag 906121 gtgcttttaa tggagtttgt tcaatatgca tgtaatgggg ccgttgcaga gattatcctg 906181 aatcggcctg atgcccatca cgccctgaat gaacagatgc tgtctgaatt gaaggaggca 906241 gtcgaaatgg cggctgcaag cgaggcgctc atcgttctcc tgagaggaag cgggaaaggc 906301 ttttcggccg gcggtgatat caggatgatg acgtcagagc atgaccctga ccaatttaaa 906361 cggctgatgg atacgattga ggctgtcacc ctgaatttat atcagatgaa gaaagtgaca 906421 attgcagcca ttcatggtgc tgctgcggga ctgggcctga gtttggcgct ttgtgcggac 906481 attgtgctcg ctgaaaaaaa cgccgttctc gcgatgaatt ttatcggcat tgggcttgtt 906541 ccggacggcg gaggacatta tttgctgaag aaaagaatcg gtgaagcaaa agcgaaaaaa 906601 ctgatttgga gcggaaaaaa actatctgcc tcggaagctg ccgatatggg gcttcttgat 906661 gggacatttg ccggagaccc tgccgaaggc gcaagaccca ttatcgaaac cctgttggcc 906721 tcccctcttt tggcgatgat cgaaacgaaa ggtatttttc aaagcctcca aattgaagaa 906781 ctgaaaaaag tgctatccct tgagcgcagc gcccaagaga gaatgagaag gaccaaggat 906841 caccaagaag gaatccgtgc ctttttagaa aaacgggagc cgaagtttca agcgtaacag 906901 atcagccgga aagctgatca tctgtgaaac aaaatcagct ttccggctgc attgactaaa 906961 cgatgagtat gactatgaag ctctttttct tttaagaggg cttcaccatg cgtttttgcc 907021 gcttcttcat gttctgcctc gaattgctcg tttaccagcg tgttccccga aggatcaaat 907081 acggtaagga aataatcagc catcaggttt ctcctccatt ttaaggttta tcagtctttc 907141 ttcatttata ttctaaaaag gaaatcaaaa tcctttatta tgctttatcc aaaattagta 907201 tataatgggt cagggaagga ggagattcag tgcttacaat tgatcacgta acgaagacat 907261 ttggagatta taaagccgtt gacggattgg acttagatat tccggaacag caaatgttcg 907321 gtctattagg cgcaaacgga gcgggaaaaa caacaacgtt tcgcatgatc ctaggattat 907381 taagcattac ggagggctca atcagctgga agggccgtcc tgtgaattat catatcagca 907441 acaaaatcgg ttatttgccg gaagagcggg gcctttatcc gaaaatgaag gtaagggatc 907501 agctcgtcta tcttgccaga ttaaaaggga tggagaagcg agaggctgta aaagagctcg 907561 ggacatggct tgaacgcttc aatattacag attacgagaa taagaaggtg gaagagcttt 907621 cgaaggggaa tcagcagaaa atccaattca tttcggcagt tttgcataag ccggagctcc 907681 tgattcttga tgaaccattc agcggcttgg accctgtcaa tgttgagctg ctaaaagagg 907741 ccgtgatctc gctgaaaaac agcggtgttt ctattttatt ttcaagccat cggatggaac 907801 atgtggagga gctttgtgag aacctttgca tattgcagaa aggaaaaccg gttgtacaag 907861 gcaagctgaa ggagatcaag cgttctttcg gtaaaaagaa tgttaccatt cactccgatg 907921 acgatctgcg ctttttgcag tcccatgaag gcattcttca atggaaggaa acggcagacg 907981 gcgtcaagct gcagattgcc aatgaagaca tttctcaaga gatttttgcg atgctccaag 908041 gaaaagggtt tatcagaaag tttgagcttg aagagccgtc actgcatgat atttttatag 908101 aaaaggtggg ggccgtctat gaataaattt tggatcatgc tttctcatac atacaaaaat 908161 aagattatgg caaaatcctt tattatttcg actgtcatca cggtgctgct tgttttagtt 908221 gtaacgaatc tggagtcgat catttctttg tttcaaggtg acgatgcgaa agaaaaaatc 908281 gccgttgttg atgaaacaaa cgaattatat ccggtttttt ctaagcagct gaaagcggtg 908341 gatacagacg gcgatcttga tgtgaagctg tcgaagcaat cggaggatga ggtcacaaag 908401 caagtcaaag atgaatcact cgatggcatg ctcatcatca aacgagatga aaaagggacc 908461 atttcaggaa catataaagc gttaacgatt tctgatgaaa gcacgtatca aacactgcag 908521 caggcgctga cgcaaaccaa aacagctgtc ggaacagcgg agctcggcgt gtcgcaggaa 908581 acgattagca gcctttatgc gcctgttact gtggggcaga aggcgctgaa agaaggggca 908641 aagtctgagg aagagcttgg ccagacggta gggcttgttt acattatgct gttcgtcatt 908701 tatttctcgg tgattatgta tgccagcatg atagcgatgg aggtcgcaac cgaaaaatct 908761 tcgcgagtta tggaaatcct gatctcaagt atgccgccga tccagcaaat gtttgcaaag 908821 ctgcttggta tcgggcttgt cgggatcaca cagcttgcta ttattatagg agccggctct 908881 ctgtcgctta agctgaacca aaagagcgaa acggcttcat ctgtcggcgg attccttaat 908941 ttgaccgacg tatctgcaac cactgtcatc tatgctgtca ttttcttttt gctcggatac 909001 tttttgtacg cgacacttgc cgcgtttctc ggcagtgtcg tcagcagaat agaggacgtg 909061 cagcaaacga tcacgccgat gacgcttttg gttgtcgccg gttttatgat cgcgatgttc 909121 ggtttgaatg cgcctgacgc aggatttatt acggtaactt cgtttattcc gttctttacg 909181 ccaatgatta tgttcctgcg cgtcggcatg cttgatattc cgttctggca ggcggctgtc 909241 ggaatcggaa tcacactgct caccattgtc atactggccg ttatcggcgc cagaatttat 909301 aaaggcggtg tattaattta cggcaattca agcgcgttca aagcgatcaa acaagcgcta 909361 cgtttagcga aaaactgatt ggaaaacagc ctggggattc tcaggctgtt tctttattga 909421 cagaacgtgc attcgcaaga attcggtgct aaaataaggg tacttcatcc tggaaaggag 909481 cagaatgttg actgatctaa cctttattca tgcggcagat cttcatcttg acagcccgtt 909541 ttacgggata tcgcatctgc cggagccgat ttttgcccgg attaaagaaa gcacgtttgc 909601 aagcgtgaga catatgatag acgccgcagt gagagagcac gttgatttca ttttgcttgc 909661 gggagatctg tttgatgaag ccaatcgaag cttaaaggct cagctctttt tgaaaaaaca 909721 gtttgaaaga ctcagagagt gcggaatttc ggtatacgtc atctttggga atcacgatca 909781 tcttggcggg gagtggacgc cgattgaatg gcctgagaat gtccatattt tttcgtccgc 909841 tgttccagaa gaaaaatcgt tttttaaaga aggcaggcgc atagcaagca tttacggctt 909901 cagctatcaa gccagagcat tgatggaaaa ccaagccgcc cgctatcgga gatcaactga 909961 cgcaccgttt catatcggca tgctccacgg cacgctgtca ggatctgaag gacacgatcc 910021 gtattgcccg tttacacatg acgacctcgt gaaaagcggg atggattatt gggcgcttgg 910081 ccatatacat aaacgccagg ttctatctgc cgagcatccg gcagtcattt acccgggaaa 910141 cacgcaagca cgccatataa aggagacggg agataaaggc tattatctcg ttcatgtgac 910201 aaacggagat atatcttatg aatttcagag agcgcatgat gtcctgtggg aaaaagcggc 910261 ggttgatgtg acggaggcaa agaatatgac agccctcttc caaatggtgg aggacacgtt 910321 ttcgaagctg cggaaaaagg ggagccctgt ttgtgtaagg cttgttttac aagggacggc 910381 gccggaatgg ctgctggagg cgccaaaagg caccttggat gagtttcttg aagctcttca 910441 ggaacaagaa gcggaagagg aacgtttcgt ttggcctctt agattggacg atgagacaga 910501 aaacgaagca aacctaacaa accttgatcc tttttttggc ggtttatttg aagacattga 910561 tcgcagcgat ctgtcagacg tgctggaagg gcttgagcgg catccagtgt atagaaggca 910621 cgcggaccgg tttagccaag aggaggtaaa ggaaataaaa gagcaggcac agataatatt 910681 gaaaagacag cttaaggtgc ttgatacatg aggcggtgac agctttgcga attatatctt 910741 tacatatcta ccaatacgga aaattttcca atcggacctt tgacttttcc gcctctcctg 910801 tccaagtcat ctacggatta aatgaggcag gaaaaacgac gatgatgtca ttcattgaaa 910861 gcatgctgtt cggttttccg aaaacgaaaa agtatgaacc gaaaacaggc ggtgtctacg 910921 gcggtgttct tgaagctgaa catcctgagt atggggtgct gaagatcgaa cggacgaaag 910981 ggactgccga aaaactaagc gtgtacacag aaaagggcga agtaaagcag ggagatgttt 911041 taaagcagct gttccagggc acagacaggt cgttgtacaa agccatatat tcgttcgacg 911101 tattcgggct gcaggaaatt cacgccttta atcgggacaa gataggggaa tttttgctct 911161 tttccagctt gtttggtgct gaagccgtat caaagcttga ttcaaggctg acgaaggaaa 911221 gcgaaaggct ctataaacca aatgggcgaa accctcaatt gaatcaggag ctggaaacgc 911281 ttaagcagct ggcagttaag ctaaaacagg ctgaagcaga ggaagcgggc tatcatcagc 911341 ttctcgagga aaaacgaacg cttgaagccc gccttgcagc cgcggaaacc gaattgaaag 911401 agacggcggg acatatccga atgattgagg gagcgattga gcgaaagccg ctgctaaatg 911461 aaaaagcgac actcgaacag gtgattgcag aatttccgga acacgcagga caatttcctg 911521 ctgacggact gcatcagctg gaaaaatatg aatcccatct tcacccgaaa tcagcacagc 911581 ttgaggcgct tcgggtgaag atggcggagt tggacaaaca gaggcaaaag cttatccccg 911641 ataaagaact attggcgaaa gaaacgctga tacaagagct ttcggcagcg tttcatatgt 911701 accaatcctg gggagaacag ctggcagcca ttcaggcaca gctgcgccag acgtctgcgc 911761 agacagcggc agggctggaa cagctcaata aaacggatga aaatgagctc ctgaatatga 911821 acacctcata tgattatgaa tggcagcttc agcaagcggt gcagcaatat gtacaggcaa 911881 gagacagaaa acggcagctt gacgagacgt ttgaacttgc ccggcaagag ctggaagacg 911941 cggaaaaggc cgttcgtgcc gcttcgtccg cgattcttga aaacagccaa agaaaagata 912001 aagaagcagc tcttagagca tatgatgaaa cacaggggca gcaccaagag caagcgaagc 912061 tcagagaaca gctaacgttt tttgaaagac agcaggctaa acagaaaaag actgtcattg 912121 cagctggtat gttgttcatc gttctctttt ctctgctgca gcaatggatt cccgccataa 912181 gtttcggcgc tgcacttatt gtgtattggc ttgtttcagg aaagtcgtct tctcgaaaca 912241 gccgagagac aagacagccc atgacggata tttcaccagc agaagctgaa atgcttagag 912301 aagcgttatg ggaggatgac cgcaataagc agcaccttct cacacagcgt gcagcgctcc 912361 agcaaaaaga ggcggcgtat gaaagggtca tccagcagtt tgaacagtgg gaagccgaaa 912421 tggcgccgtc ctttacacag gttgagcgtt ttatgaatga gctcggattt aaggaagatc 912481 catcattttt gcttgatgca tacagcttaa tgaaggatgt taaaaaagaa gtgaagaaaa 912541 agcatgagct gaccatagaa gcaggcaggc tgaaaaagca ccggagaaca ttcgaagaac 912601 gcgtcagtat gcttcttccc gtgaatcaga gtcaggatat ctccatttcg gacgcccttc 912661 acacattgcg gaaaaacatt gaacgtgaaa aagaaattga gaagcaaaaa aaggaaattg 912721 aaacagatat tcattataca aaggaacaga tgcttgaact tgagcaagaa atacagtatt 912781 tccacgcaca gattgaacag ttatttgccg cggctgctgc aaaagacaga gatgcgtttt 912841 ttgccatagc cgccatcagc aggcaattga aggatacgga gaacaagctt catcacgtaa 912901 acgcacagct tcaaggcggg tacccggagg aacttgaact ggcggattcc aatacgcttt 912961 ctgaattgaa agataagcaa tttgttgaga atgaaagaaa agagcggctg actgaggaga 913021 tcgagcagct ccgcagccaa atcgcactgc tctcagtcaa acaggaacaa ttagaggctt 913081 cgggaatggt ctcagacctc aagcttcaaa ccgaaatgca aaaagaacgt gtgaaagaaa 913141 cggctaaaaa atgggcctcc atacaaatgg tcaaacaggt gatcagaaac aaattggagc 913201 ggcataaaaa aatcgagctt ccgcgccttc tggagacggc aggagaattt ttccgtcctc 913261 tgactgacgg aaactaccaa accatttatt tttccgaaac ggatgattcg atcatggtta 913321 tgcatcgcga tggcactgtc tatcatgcgg aagagctgtc acaagggacg tgtgaacagc 913381 tgtatacagc gatccgcttt gctttggccg ttacgcgcca gggtgagtca aagcttccgt 913441 tccagcttga cgacagtttt gttcattttg atcaggaaag gctgaaacgt gtattacatg 913501 ttctgtatga tttatctgaa ggcggtaggc agattttgta ttttacatgc catgagcacg 913561 taaaagatgc atttcatagc agccaaatca tccatttggt gtcataaaag aggttctata 913621 gctgaaaatc ggtatgtgat atactggtat tatgtaagat acggagggag ctttaataga 913681 atggctaaag ggattatgct acatgaggtt ggcgaacagg tggaccagta tctattgatt 913741 aaatcctcga cgaaagggat tgcaagcaat ggaaaaccgt ttctgacgct gatgctgcaa 913801 gaccagtcag gcgatattga agcgaagctg tgggatgcca agcaaagtga tgaagtgacc 913861 tatgcgccgc agacgattgt caaggtcgtc ggcgatgttc accattatcg cggacgcacc 913921 cagctgaagc taagaaatat cagaccggta agcgagcaag aaaacgtcaa tattgatgat 913981 tttttagaaa ccgcgccgat tccgaaaaat gaaatgatgg ataccatcac tcaatatata 914041 tttgaaatga aaaatccgaa tatccagcga atcacaaggt ttttggttaa aaaacacgaa 914101 gctgagttta tggattatcc ggcggctacg aaaaaccacc atgagtttgt ctcaggtttg 914161 gcgtatcatg ttgtctctat gctgaacctg gcgaaagcaa tagcagattt atatccttct 914221 cttgatcgtg atctgcttta cgccggtgtt atcctgcatg atcttggaaa agtgaaggag 914281 ctgtccggcc ctgtttccac ttcatatacg gttgaaggca atttgctcgg ccatatttcc 914341 atcatggtga cagagctttc aaaagcggct gaggagcttc aaatcgattc tgaagaggtg 914401 ttaattcttc agcatttgat tttgagtcac cacggcaaag cagaatgggg cagcccgaaa 914461 ccgcctatgg tgaaagaagc ggaaattctt cactatatag acaatctgga tgcaaaaatg 914521 aatatgatgg acagagcgct tgagcgcgtg aagccgggcg agtatactga acgtgtattt 914581 gcactggaaa accgttcctt ttataaaccg acatttcata aataacttaa aaaggactga 914641 tgctgacata ttcagctcag tcctttttga tgcgtctttc ccgcacataa ctcgtctcat 914701 tcccgcatat ggttaagaat aaagaatcta tgcaaagggg gaggagcccg tgttattttt 914761 tccgtggtgg gtgtatcttt gtattgtagg catcattttc agcgcatata aacttgtggc 914821 ggcagccaaa gaggaagaaa aagtagacca ggcttttatt gaaaaagaag gacagattta 914881 tatggagagg atggaaaagg agcgagaacg ccgcagttct cagcagcatg aagaagaaaa 914941 tcaaaaccat tccatcgcat aaaaaaagct gtgcggctca atgagccgca cagctttttt 915001 tattatttag aattgcttga agatgaagaa gtgctgttgc ttgttgaaga tgtattaaat 915061 gtgtctttca gatctttatc ttttacttcg atgtcagcct tcttcatgac tttttgaaca 915121 gcttcctgaa cagctgcgtt gtcatttaat ttttgttcaa gcacttcaga tttcagttct 915181 tttttcatat catcatattt gccgcgttct tctgtctttt taatgatatg gtagccgtat 915241 tgcgttttga caggatcact gacttcacct gtttttaatt tgaatgcagc tttgctgaat 915301 gtttcgtcca tttggccttc ttttgcgaac cagccaagat ccccgccttt tgaagcagag 915361 ctgtctgttg agtattcttt cgcaaggtct tcaaacttct cgcctttttt cagctttttc 915421 tctacttctt cagctgtctt tttatcagca acaaggatgt ggcttgcacg gattttgcct 915481 tttaagcctt cccagtactc tttgatatcg gcgtctgtta ctttgatgtt atctttagcc 915541 gctttttgtg tcagcaattc atattttact tgttctttca ggtaatcttt gccatattgc 915601 ttttcgaggg cagtatattg atcgccaagc tgcgttttgt attctttcag cttgttgtca 915661 atttctttat ccgaaacttt atacttcttg tccaatactt tttcttgcac tagctgtgtc 915721 agtacgcttg cgccagctgt tttcttcatg tttgtgtaaa gctcgccttt tgtgacatcg 915781 cctgcgtctg tttttgcgat aacttctttg tcgccgctgc tgcaagcact gagagcgagg 915841 atgcttgtag cagtgatagc tgctattgcg attttcttca ttgttttcaa acactcctaa 915901 tcattccaaa ttaaattacc tatgcgtatc ataacatatt gtggctttct gtaaaaagat 915961 tttaaataaa gggcattcgt ctagtcaaac ttttgctgat gacatactta tatattgatc 916021 aagaaaagga ggtatgtaac atgagcggag gatactctaa cggattcgcg ttgctcgtag 916081 tactgttcat tttgcttatc atcgtaggtg cagcttacat ctactaagca gcccgaggat 916141 cgcttgcaac ataagcgatc ctttattttc actagcgcct aatcgtttca aacatgaatt 916201 gcataacatg taattggtaa ataaagctta ttacaggagg tgctatttaa gatgggtgaa 916261 gtatttgcag gcggattcgc tttattggtt gtgttattta ttttattgat tatcatcggc 916321 gcttcttggc tgtactaatc aacataaaaa agcatagctg cttaatcagc agctatgctt 916381 tctttcgtat ttacactgta aaggagatct ccacaaacga agagatcagt aaaattaata 916441 tagatacatt aataaatcgg aataccttat cttgccgctc ttcaggaatc tctctgacaa 916501 ggcataatgt attggtgagc ctgtttatga aatataaaat aaacacggca gccacgataa 916561 aatagaataa aatgatggga gattccccct ctctctgaac tgtcccatat tacattacca 916621 aatatttatt aaaaaagata gaatgcaaat tgaaaaatcg ccaccagcac cagggtttga 916681 ctacttttca acaagaatat ccaagccgtc agcttcctga tcaataaaag cggttttcgg 916741 tgcttttatc agcttgagag ccagcaggaa atcaggcaga cagtagccgg cgtgaatgcc 916801 cgagatcatg caaaaataat gagcgtgatt cggaaatgcc agtgctgcgt aaaacaatac 916861 cggtgtaatc agcaagaacg ggctgacgag tgaaatcagc attgttgttt ttggtatacg 916921 tttccatgtg cgcatgcgca atatgtaaaa ctttttttct atttttcttt ttttgcagat 916981 gattggcagg acatggatga ctttatgtac aaataaaata acgacgagca aaccgccgaa 917041 taaagataca tattcatcgc ttaagcttgt gccaggccgc agcagctcaa aagctaaaaa 917101 ggtagatata aaaaccaaaa tcataaaaca tacagcagtt aatattatgc gaacggcgcc 917161 ataatccttc atgagattta tggtcttcca gcaattcatc aaagtcatcc ttccatacat 917221 cttgaataga atctcaaaat aatttactcc tcccaagaga aaaaatcaat gcttttttaa 917281 gaaaaaatat catccggcag gtattttttt gaaacaagca aacaaactgc gaaatatggg 917341 gttagaactt tcttctcagt gaattatcag ctaaaataag attaaagata gaaagaagtg 917401 gtgtggatgg attcgatgga tcatcgcatt gagcgattag aatattacat acaattatta 917461 gtgaaaacag tagatatgga caggtacccc ttctatgcgc ttctcattga taaagggctg 917521 agcaaggaag aaggggaagc ggttatgagg atatgcgacg aattgtcgga agagctggca 917581 acacaaaaag cgcaaggatt tgtaaccttt gataagctcc ttgcgctttt tgccggacag 917641 ctgaatgaaa aattagatgt tcatgaaaca atttttgccc tgtatgagca ggggctttat 917701 caagagctga tggaagtctt tatcgacatc atgaagcatt ttgattaact gtttacaggt 917761 tcgagctctt cagccggttc atccgccgca ctgtcctttg cttttttctt caattttccg 917821 tttacgcttt caaagtcatt gtcaatattg gtgagtgacg tttcgaaaat ttccataaaa 917881 tcatcgccgt agatatggcg tatcatacac atcatttctg ccacttcagg aaattttccg 917941 aataaatgat ataaaggctg tgacccttta aaaacagcgt tgcgtgtcgg atcaaattcc 918001 tcaagcaagc tccagaatac ctcggtacct tcctcagtca attggacata tgtgttccgt 918061 ttatcattca gccgtttgga gaaccttaaa tatccccgtt cttccagctt ttttgaaaag 918121 ttgaatgcgg ttgatacgtg catgaccccg aatttcgcga tttcagaaat ggaagctcca 918181 ttcaattgat acgcaatcca taaaatatga tgctcattaa tattcaggtc atacggtttg 918241 agccattgct gccaatcctt ctcgatcgat ttccaaagag ccttgctaag ctgagccatt 918301 ttctgggtga aaaccagagc ttctttcaca tcatagggcg gttccactcg attcattacg 918361 tcacctgctt ctctttttct ttttctctat tatgccaata aaataaagat taataaagat 918421 gaaaatgtaa gaatttttta ataaattcac aaaccattgc gacgaaaggg tttttcggcc 918481 aaaaaaaata cgggtccaat tttggcccgc atttttttct tttgaatagg atattagttt 918541 tgtaaggttt tctccagctg tctgattttc tcttcgatat cggcaatttc tttttgcaga 918601 tcctgctggt gaggcttgat ctcttcctgc cattttttaa ttgatgtttg gagctcgccg 918661 cccacgtctt taataacatc cgtgctttct tttgccgctt tgatcagctg gtcttttaat 918721 gcaagcccgt ctgactttaa gcgtttgatt gtttcttcaa aagaatcata attggttttc 918781 attttttcac gcagctgctt tcctgaggaa ggtgcagtaa gaagaaccgc tgctcctccg 918841 atgatgccgc ctacgaatag tcctgttaat agagaacgtc cgctcgccat tacaatcacc 918901 ccgtcttttt cttcaaaata ggattcattc agcatttttc atttttgttg aaagcctgaa 918961 cttctataca tagcttgctt tattttagca tattttttaa gtgaaaagga gggagaaggt 919021 tgtctgtctt tttgattgta ttatcctgca tcacccttgc cttcgcttca ggcgctgttt 919081 actatatcaa acttctcagc caggctgctt cttatccgcc caagagggtt atccggcaga 919141 aagcgcttgt ttgttcaacc ggaaccgcct ttacactatg tcttatcttt ttcacaaaac 919201 tcctcgctta aaacatgctg acatgctgcg ggcgctctgt tcaaaaaaac ctctcccgga 919261 agcggaagag gttttgtgtg acaattattt agcagcttcc ataaagcttg aacgccttaa 919321 aatggtttgc acaatcggat aaataatgat cattgagatt gtattcagca cagcggccgg 919381 cagaacaaca gccgcgaaca atgcggcgaa accgcccggt aaaccgacga tcaataaagc 919441 tgacgataga aacacaattc ctgataagat ggtcccgatc actgtcagca cagcggctgc 919501 acctgttttc cggctctttc tgaacaagag aaacagggag aagaacagaa acgctgatac 919561 gggtttatca atgatgttag ggatctgtcc ggctggaaac gcggttgtaa gcgcggaaat 919621 gattccggtc acgatcccga tgacgagtac attttgcacc cgcgggaaca gcagaatgcc 919681 catgaacatc atgatcagca tcatatctgg tttcatgccg cctaaaaagg gcggaataat 919741 ggaatgaagc gctgcgccga ttgcggcaaa cagagccata atgactaact cttttgtttt 919801 cataactatg ctctcctctg ctaagctttt tgccctccaa taatatgctc atcatttatt 919861 gcgaaggctt tacagaatgt gttatgcaaa cagtatacca aacggacggt ttgcatagcc 919921 agacttttta ctcattttcc tgctggaatt tcttcatgaa cgcagctaat ttttcacagt 919981 cttcgagaga gaccgcgtta taaatagaag cgcggcagcc tcccaccgaa cggtgtccgc 920041 caaggccgat catcttcgca tcttttgctt tctgaacgaa tgttttcgtt aattcgtcat 920101 cccgaagcgt gaatgtgaca ttcatgcgtg agcggctgtc ttttctggca tgtcctttat 920161 agaagccgtt gctttcatca atacagctgt agagaacctg cgctttttgt tcattgcgct 920221 gttcaacagc ttccacaccg ccgttttcct tgagccattc cagaacgagg ctcagcatat 920281 aaatcgcaaa tgtcggcgga gtgttgtaga gtgaatccgc tttgacatgc gtggaatatt 920341 tcaagatttt tgggacgttc gcattttcat tttgcagcca gctttttttc atgatgacta 920401 cagtcacgcc ggaagggccg aggttctttt gggcgcctcc gtagatcaca tcaaatttgg 920461 acacatcgat ttttctgctt aaaatatcgc tggacatgtc ggctacgagc ggaattggag 920521 aattcggaaa ctcctgccac tgagtgccga aaattgtatt gttggatgtg atatgtaaat 920581 atgcgccgtc ttttacatcc gtaaggtcaa cctctggaat ataactgtaa ttgtctgttt 920641 cacttgtagc ggtgatagac gtgttcccga acagtttcgt ttctgccagt gctttttcag 920701 accaagcgcc ggtcatcaca aaatgtgcgg ttttttcagg tgttaaaaag ttcatcggaa 920761 gcattgagaa ttgaaggctt gccccgcctt gaagaaacaa gatatcgtaa tcttccggaa 920821 tgcccatcag ttcgattaag aggcttttcg ctttttggtg caccgcttca tactctttgc 920881 tgcggtggga aagctccata acagacatgc cggattcgtt aaaatcaata aattctttct 920941 gtgctttttg cagaacttcc agtggcagcg ctgcaggacc tgcgttaaaa ttcgttgtac 921001 gttccattat gatctctccc tgttttccac gttaatgtat aaaataatac aattatccta 921061 tcacaaaaat tcagtttttt gataaaaaat tagaattatc aaaagaaatt gacggatgtt 921121 tgcgaaatgt tcacaaaata aaataacctc atcttatgat gaggccaggc gttttgcgat 921181 agaggaagag atgttctgca gatcctccgg tttataatca tcagcatgcg ttttccaaac 921241 cgctccgaat ccatctcctt ttccgtagcg agggataata tgcatatggt agtggaacac 921301 agattgtcca gctttttcgc cgttattgtt cagcgtattt aagccgatcg gttcaaattc 921361 atcccggata gcgcgggcga tttttggaac agcatggaaa tattgttttg ctaattcatc 921421 tgtaaattca tatacattct caatatgtgt tttcggaatg acaagcgtat ggccttttgt 921481 cacttggctg atatcaagaa aggcaagtac atgttcatct tcatacacct tcgctgatgg 921541 aatgtcgccg gcaataattt tacaaaagat acaattctct gcacaatgca tgagggttcc 921601 tccttatgaa attgtttagt atgtatacat tcatcgtacc acagaaatgc agaaaataga 921661 aaacaggatg aacggcgagc gttcaccctg aatgcagagg aagagcttat atgaagaaaa 921721 tgtgttatgc ctttggtaag cacctcattt gtcaataaaa tgaagacttg tttaatgcct 921781 aacgattcct gcgataaaca cctcatttga caatttgctt catacatgaa gaattcatca 921841 attcagtgaa gagaaatggt ttgagcattg gacatgttta ttttctatcc aactgtttct 921901 aagacgtctt tgacaaacac ctcatttttc agttgatatg cttttcctct acaactttta 921961 tgatgtccag aaccctgtct ctttatgaca gcaaattcat catttgttaa aagggaattg 922021 tttcaaatca ggccttgttt ttggtactat gaagaaaaac actataaggg gagaaactat 922081 gtctctgcta tcggtaaaag acttgaccgg cggatataca aggaatccgg ttttaaaaaa 922141 cgtatcattc acccttgaac cgaatcaaat tgtcggctta atcgggctga atggtgctgg 922201 taaaagtaca acaatcagac acatcatcgg gctgatggac ccgcataaag gttcaatcga 922261 attaaacggt aaaacgtttg ctgaggatcc ggaaggctac cgttcacaat ttacctatat 922321 acctgaaaca cctgttttat acgaagaatt gacgctgatg gagcatcttg aactaacagc 922381 catggcatat ggactgtcaa aagaaacgat ggagaaaagg ctgcctccgc tactaaagga 922441 attccgaatg gaaaagaggc tgaagtggtt cccggcccat ttttctaaag gaatgaagca 922501 gaaggttatg attatgtgcg catttttggc agagcctgcg ctctacatta ttgatgagcc 922561 ttttctaggg cttgatccgc ttgccattaa cgcgctgctt gaacggatga atgaagcgaa 922621 aaaaggcggg gcgagcgtgc tgatgtcaac acacattttg gcaacggcag aacgctattg 922681 cgattcgttt attattttac ataacggcga ggtgcgggcg cgcggcacgc tgtcagagct 922741 cagagagcag tttggaatga aggacgcggc gctggacgat ttgtatcttg agcttacaaa 922801 ggaagacgct ggccatgaat aatatgcttg atatttggca gtcgcggctg caggagcata 922861 tcaaagaaac aagaacatac atgaaatata tgctcaacga tcacctcgtc attgttttga 922921 ttttttttct agcgggcgct gcaagctggt acagcaaatg gatacgggac attcccgctc 922981 actttccgtc cttttgggtg atggccgtgc tgttttcgct cgtattgaca agctcttatg 923041 tgcgaacgct tttgaaggag gctgaccttg ttttcttatt gcctcttgaa gcaaaaatgg 923101 agccttactt gaagcaggcg tttgtctaca gctatgtgtc tcagctgttt ccgctgattg 923161 cgctgagcat cgttgcgatg ccgctttatt tcgcagtcac tccgggagct tcgctcgtat 923221 cgtatgccgc ggtctttgtc caactgttgc tgctgaaagc gtggaatcag gtaatggaat 923281 ggcgaacgac tttccaaaac gaccgcagca tgaaacggat ggacgtcatc attcgctttg 923341 cggcgaatac actcgttctt tattttgttt tccaatctgt ttatatgtat gcgcttctcg 923401 tctatgtcat tatggctgtt ctttatctgt atatgtcttc cgcagcaaaa cggaaaacat 923461 ttaaatggga gagccatatt gagtccgaat tgagacgaaa gcagcgtttc tatcggattg 923521 ccaacctgtt tactgatgtg ccgcatttgc gaaagcaagc caaacgcaga gcttatctcg 923581 actttttgct gcggcttgtg ccgtttgaac agcgcaaaac atttgcctat atgttcaccc 923641 gcgccttttt gcgttcgagc gattatttgg gcattcttgt cagattaacg atcgttttcg 923701 cgctgatcat tatgtatgtc tcagccagcc cgctgattgc cgcggttttg actgtgtttg 923761 ccattttcat tacgggcatt cagcttctgc cgctcttcgg tcactttgac catctggcgc 923821 ttcaagagct gtaccctgtg caaaaagaaa caaagctgaa aagctatttc tctctattaa 923881 aaactgcact tagtattcaa gcgctgctga tgtctgttgc atctgcctat gcagccggct 923941 tgaccggttt tctgtacgcg ctgatcggtt ctgccgttct gatttttgtt gttttgcctg 924001 cttatatgac gaccaggctg aaaaagcacg gaaagctgtg aactgaaaag aggtaatcaa 924061 atgacagata atcagctgct gatgcaggaa gctttggaat ggaaaatgca ttttttgcga 924121 aaggattcca tgtttgaacg cttttcgaag cgtgtccaga cgaaggtgaa tgaacggatt 924181 cctgaaaaaa tccatacggt cgtcaccgag agtgtgaaaa aaatggtaga agcgacaatg 924241 gccggctcta atatcatcac ctataaaaag gatacaagtg cactgtcgct cagtgaaaaa 924301 aacgaattgg cgaaaaaaac gattgtttct tatcaaaaag tggcagctgc tgagggagtc 924361 ggcaccggag cgggcggcat ttttttaagc attgctgatt ttccgctgct gctttcaatt 924421 aagatgaagt gtttatttac cttgtcttcc atttacggct ttgatgtcaa ggatgcacaa 924481 gaaaggatat ttttgctgct cgtgtttcag cttgcgtttt cgagtgatga tggccgtaag 924541 tcgctttttt ctgtcatcga aaattgggag acggagaaaa agagcatcga ctggagagtg 924601 ttccagcagg aatatcgcga ttatatcgac gtcgtgaagc tttttcagct tttgccgggc 924661 gtaggagcgg cagtcggcgg aattgccaat tataagctgc ttgctcagct tggagaaacg 924721 gcaagacatg tttttcatct gaggatatta aaggaaacag ccggagaata aacactccgg 924781 ctgttttttt atagctgatg ataggtgatc gcagcgccgg caaggacctt ggccgctgtc 924841 agcatggctt tttcgttgat atcaaatttc ggatggtggt gggaatagac tcgctctggc 924901 tgttcgggag cggcgcctgt aaagaaaaaa gtgcccttca cgttttgtaa gtaataagca 924961 aaatcctcgc cgcccatttg tggttcaccg tcaatgacct gctgaacgcc ctcggtattc 925021 tttgcggtgc tcaccaagtg gttcgtttct gcaggatggt tcacaaccgc tggataaccc 925081 tgttcatagg tgtactcata ggacgcgccg tgcatgctgc atattccttt tacaaccgct 925141 tcaatttctt tctccagaat gtcccggaca ttttcatcaa aagaacgcgc tgtgccgatg 925201 agtactgctt ggtctgcgat gacattaaac ggattgtcgg cgatgaagga gcctgtcgaa 925261 atgacggcgg attgaatcgg attgactttg cggctgacaa tgtgctgcaa agaggaaacg 925321 atttgcgaac cgattaggac ggcgtcttta gtatcatgcg gatgagcgcc gtggccgccc 925381 tttccgaaga ctttaatcgt aaatcggtct gccgccgcca ttacggcgcc ggggcggcag 925441 agaatagttc cgagcggctc agttgcccaa agatgagtgc cgaatatcac atccgtgttt 925501 tcgagacatc cgtcatcaat cattggcttt gcgcctccag gataatattc ttctgcatgc 925561 tggtggatca tcacaaatgt tcccttcagt tcatgtctgt tttggtgaag gaccttggcc 925621 actgcgagaa gagctgcggt gtggccgtcg tggccgcatg catgcatgac accaggcact 925681 ttggaggcgt aagggacatc tttttcatct tgaatgggga gagcgtcaaa gtcggccctc 925741 aaagcgactg tagggccggg ttcgcttcct tctatatttg ctaaaacccc tctaccgcca 925801 acgtttgtgc ggattgggac tcctaacgat tcataatagg aagcaataaa tgcggcggtt 925861 ttttcttctt gaaatgagag ctcaggatac atatgaaaat ggcgcctgat ctcaaccatt 925921 tcttcaaaac agccgtcgag ctgtttgttt atctctttct gcagtgtgga tatggacaaa 925981 gccgcttccc ccttttctat gcttttccat gattgtatag aaaaagtctg aatatttcaa 926041 ctcatgctgt tttaaagcat catcacagct gcgagggttg tcaccaaaag gccaatcgcg 926101 acgggaatga agttttttct ggcaagctca aaaggatcaa ctttgcaaat ggccgcggcg 926161 ggaatcaaag cccatgggac cagtgttcct ccgcccaccc agatggcaga gatttgtccg 926221 agcgcggtca gaatagcggg atcggcatgg agagcggacg aaaagagctt tgcgatggag 926281 ccggcgagag aaatgccaga aaatcctgag ccgtcaaggc ctgttatggc tccagcggca 926341 gttaatgcag tggcggcaag ctcctttgac ataggcatca tatgggataa agcaatgcca 926401 agatcgttga caatgccgtg ggaaccttta gggagtgaag tgcccagtat gctttcatag 926461 cctgagtcgc caagataaaa gaaagcggca atcgggatga cggggccgaa aaccttaaaa 926521 ccgaacttaa atccgtcaat aaaatagccg gtgatttttt caagcccttt atgcttatac 926581 acgaaaaaat gaacggtaaa gaggatacaa attgcagacc cgccaattaa cgcggttgca 926641 tcatttcctt gtaggttaaa caagagcatg caggcgatat ctgcaagaaa ggcaagcgga 926701 atcaaaaaag ccagtatgga ccgcaggcgt tttggcaagt acagcgagtt gtcttgttcg 926761 ccggaaagaa cgggggaaaa agaagtggga tgctcctgtt ttttgcgttc gcgctgaatc 926821 atgataaagg cagcagttgt tgttgtcaca cccataatca gcacaagcgg aatactggcc 926881 gagacgacat caccgactgg aatgcctgct gcatccgcag tcagctttgg cgccgcctga 926941 atgacaaagt ctcctgacag ggcaaaaccg tgtccgaata agttcatggc catggccgcg 927001 gcaagaggcg tcaaaccggc acgtgcggct gcggggagca ggacggcgcc gatcaaagcg 927061 acacccggag aaggccagaa gaatagagaa atggcgaaca tcaggcctcc aatcagccaa 927121 taggcagtca caggccctct cacaaggctt gcaaagggag aaatcatcgc ttcatttatc 927181 cctgtttttg ttaacaaatc actcattgaa acgataaagc aaatgatgaa aatcgtgggc 927241 agcagttcgc cggccgcata gataaagctg tggaataaac tgctgacaga agctgaaagt 927301 gaatggctgg cccatagcga tatgataaaa atgccgaata gagaaataaa tgtcgtgtct 927361 tttctcagca gcataaatag gataattgca ccgataaaaa acacatacag aacatggaca 927421 ggcaaaatcc cgacttccat catcgatcac tccttccgct tacagattat tcataggcgg 927481 gcggaaggtg ccgggacaga ggggagggtt atgatggaag atgaacattg atctgtttca 927541 gctgctcaat cagatgatgc cttaatcctc tattcgcttt ttgcagatgt tttgggaagc 927601 attcaggaga aaaaatgacg cacccttcag caagccagtt ttttctatag gcgatgatgc 927661 tttccgatgg ctctatatga gttatcctcg tgctgcatct cgtactcatc aaatccgaac 927721 tgaaaaccgc agcacgggca gatttcatga gaatgattgc cttcatgatc atatggcggt 927781 tcagccaatc cttaaacccg cagactgggc aagtatgctt cattttgctt tcctcccaat 927841 aaaataagct gccggacatg ccggcagcta ttcgacagcg aaatatgtgg tgacatagga 927901 aggccgggag aagatcgacg ttgtgtcaat tccggcagat gtatcgcgtt ttttgtgggc 927961 ttctttgtaa gaaccggact gctgccagtc ttgaaaggcg ctttccgttt cccacaaggt 928021 cagaatgaca taggtgtcac tgtcaagcgg acggagcact cgaattgctt caaagccagg 928081 ctcgttttcg acttttcccg ctctgttttt aaatctgttt tcaaacagcg gacgcccttc 928141 ctgagtaacg gcaatattgt tcaatactgc aaaaccggga tgtttgatct ctccgacttg 928201 gtcaatgact tcataagcgt gtggtgcctg gaaaacggta tctccgtttg tttcatgaat 928261 taaaatggcg ttttcctgcc cctgcatcaa aaggatattt tctgagggat gcttctgtac 928321 gatcgttttt aaaaaatcgg ctgtcccata tgtaatataa accttcatat cagccacctc 928381 ctgcttgcta gtatatcaaa acaatggtat aagtttctat tggcgagtgc ttcgaacata 928441 attccaaaca atttttccca tactaccttt agaaaggcga ggtgagttca tgtttaagat 928501 aaagaaaaag aaacttttta tacctatcat tattttagtg ttaactgctt ttctcgcttt 928561 aataggatat atttcaatta tttttctcgg ccattatgtc atagatgaaa aaaagcttat 928621 tcttcatgct tcttcaaaaa ttgttgatca aaacggagat gaggttgcaa gcctgtatac 928681 agaaaatcgc gagccggtct cgatcaatga gattcctaag caggtcagag aagcgtttat 928741 cgctgttgag gataaaaggt tctatgagca tcacggcatt gatgcaaaat ccgtcggaag 928801 ggcagtgtac cgcgatatat tagcaggcgg aaaggtggaa ggcggaagca cgatcaccca 928861 gcagcttgcc aaaaatattt ttctgacaca tgacaaaaca tttctaagaa aaacaaaaga 928921 agtgatcatt gcgattaatc ttgaacggga ttacagcaag gacaagctgc ttgaaatgta 928981 tttaaaccag ctttacttcg gacacggggt ttacggcata caagcggcgt cccactatta 929041 ttttaataaa gaagtaaaag atttgactgt atctgaaggc gctgttttgg ccgctattcc 929101 gaaggcgcct tctacgtact ctccaatttt gcaccctgat aaaaataagg agcggcgtga 929161 tacaattcta ggtatgatga atgaccaagg ctatatcagt gcgaaagagg ctgtcaccgc 929221 acagggccgg acgcttggac tgcatgtgaa gaaacagtcg gaaacacctt ggtttgacag 929281 ctacattgac cttgtgatca aagaggcgga agacaagtat tccatttccg gagagcagct 929341 tcttcaaggc ggatacacga tcaaggtgcc gctcgattcg aagctgcaga agacggctta 929401 ccaggtgatg aaagagggaa gctattatcc cggaacagat cagaatgccg agggaagcgc 929461 ggtctttatt aataacaaga caggcggtgt agaagcggcc atcggcggaa gggattacac 929521 atccaaagga tataaccgtg tcacagctgt ccgccagccg ggttccacat ttaagccgct 929581 tgctgtatac ggaccggcga tgcaggaaaa gaaatttaag ccatattctc tattgaagga 929641 tgagttgcag tcctacggag attatacgcc gaaaaactac gacagccggt atgagggcga 929701 agtcactatg tctgacgcca ttacgtacag caaaaacgcg ccggctgtct ggacgctgaa 929761 tgagatcggc gtcgaaacag ggaaatctta tttgaaagca aacggcattg atatccctga 929821 tgaaggcctt gctcttgctc taggcggctt ggaaaaaggc gtttcaccgc tccagcttgc 929881 cggcgcgttt catacatttg ccgcgaatgg aacgtatact gaacccttct ttatctcgag 929941 cataatagat gaagacggag aaacaatagc cgatcataaa gaagaaggaa agcgggtatt 930001 cagcaagcag acgtcttgga atatgacgag aatgctgcag caggtagtca aaaagggaac 930061 ggccacgtcc ggcacctatc acggcgacct ggcgggaaaa acaggttcaa catcttatac 930121 aggcgtctcc ggcgcgacaa aggacgcctg gtttgcaggc tatacgccga aaataaccgg 930181 ggcagtctgg atgggctatg acaaaacgga tcaaaaccat tatttgaaag ccgggagctc 930241 atacccgacg cggctgttta aggatatttt gacacaggca ggagaaaccg gtcatgtgtt 930301 cacaaagcct aaaaacgtta aagaactgga aagcccgatt gagctgaagc cggtcaaaac 930361 actcacagcc gattacacat ttaaagcagc ggggctcttt actattgaat taaagtggga 930421 cgctcaagag gatgatcggg ccgtatacag aatttatgta aacaaggacg gcgaggagac 930481 gcttcttgat tcggttgaag ggaagggaag ctatgaaatt ccttatgcca acttattttc 930541 gggcgcgtct tataaaattg tgccttataa tacacagaca aaaagagaag gggaaggaac 930601 cgattacgtt cagccaaaat tgttttcctc ttaatggaat tcggcgattt tttgaacttt 930661 gagctacatt tctataccat ttgcctaaaa caaggtatag tgtaataagt caagaaatac 930721 gaacgtatgg ttgccgtatg aaaggtggaa atcagatgag taaacgagaa acgtttaacg 930781 agacgttttt aaaagctgcg cggggagaaa aagcggatca cacgcctgtg tggtatatga 930841 ggcaagcagg gcgctcacag ccggaatacc gcaagctgaa ggaaaagtac ggattgtttg 930901 agatcacaca tcagcccgaa ctttgtgcgt atgtcacaag actgccggtt gagcaatacg 930961 gagtcgatgc tgcaatcctt tataaagata tcatgacgcc gctgccgtca atcggtgtgg 931021 atgttgaaat caaaaacggg atcggtcctg tgattgatca gccaatccgg tctctggcgg 931081 acattgaaaa actcggccag attgatccgg aacaggacgt gccgtacgtg cttgagacga 931141 ttaaactgct tgtcaatgag cagctgaacg tcccgctcat cggtttctca ggtgcgcctt 931201 ttacgcttgc aagctatatg atcgaaggcg gcccgtcgaa aaactacaat aaaacaaaag 931261 ccttcatgta cagcatgcca gatgcatgga atctgctgat gtccaagctt gccgacatga 931321 tcatcgtgta cgtgaaagcg cagattgagg caggcgcaaa agcgattcaa atctttgatt 931381 cgtgggtcgg cgcattgaat caggcagatt acagaacata catcaaaccc gtgatgaacc 931441 ggatcttttc agagctcgca aaggagaatg tgccgctgat catgtttggc gttggcgcaa 931501 gccatcttgc aggtgattgg catgaccttc ctctcgatgt tgtcgggctt gactggagac 931561 tcggcattga tgaagccaga tcaaaaggaa ttactaaaac agtgcagggc aacctggacc 931621 cgtccatttt gcttgcgcca tgggaagtca ttgagcagaa aacgaaggaa atacttgatc 931681 agggtatgga gtcagacggc ttcattttca atcttggcca tggggtattt cctgatgtca 931741 gtcccgaggt tttgaaaaaa ctgacagcat ttgtccatga atattcacaa aacaaaaaaa 931801 tgggtcaata ttcctaagca tatcttttgg tatcttaatg atatcctgtc aaaatgtttg 931861 tatcagatca ttaaagaggg tgtaaacagt gagtagaaag aaaatggggc ttctcgtgat 931921 ggcgtacggc acgccttata aggaagaaga tattgaacgt tattatacac atatcagaag 931981 aggcagaaag cctgaacctg aaatgcttca agatttgaaa gacagatacg aagcgattgg 932041 cggcatttca ccgcttgccc aaatcacaga acagcaggcg cataatctgg aacagcactt 932101 gaatgaaatt caggatgaga ttacgtttaa agcgtatatc ggactgaagc atatcgagcc 932161 gtttattgaa gacgccgtag cagagatgca taaggatggc attacagaag cagtcagcat 932221 cgtgctggcg ccgcatttct ccacgttcag cgttcagtcc tacaacaaac gcgccaaaga 932281 agaggctgaa aaactcggcg gcttaacgat tacgtcagtt gaaagctggt acgatgaacc 932341 gaagttcgtg acatattggg ttgaccgagt gaaggaaaca tatgcgtcaa tgcctgagga 932401 tgaaagagaa aacgcaatgc tcatcgtatc cgcacacagc ctgccggaaa aaatcaaaga 932461 atttggagac ccgtacccgg accagcttca tgaatcggcg aaattaattg ctgaaggcgc 932521 aggcgtttcc gaatatgctg tcggctggca aagtgaaggg aacacgcctg atccttggct 932581 cggacccgat gttcaggatt taacacgtga tttattcgaa caaaaaggct atcaagcatt 932641 tgtatatgtt cctgttgggt ttgtcgcgga tcacttagaa gtgctttatg ataatgatta 932701 tgaatgcaaa gtggttactg acgatatcgg cgcaagctat taccggccgg aaatgccaaa 932761 tgccaagcct gaatttattg atgctttggc aacagtcgta ttaaaaaaat taggacgtta 932821 aagaaggcga tgaacatgag tgacggcaaa aaacatgtag tcatcatcgg cggcggcatt 932881 accggtttag ccgccgcctt ctatatggaa aaagaaatca aagaaaagaa tctgccgctt 932941 gagctgacac ttgttgaggc aagtccgaga gtcggcggga aaatccagac tgtcaagaaa 933001 gacggctata tcatcgaaag agggccagac tcatttctgg aacgaaagaa aagcgccccg 933061 cagcttgtta aagacttagg tcttgagcat ttgcttgtca acaatgcgac cgggcaatcc 933121 tatgtgcttg taaaccgcac cctgcatcca atgccgaagg gcgctgtaat ggggataccg 933181 acaaaaattg cgccgtttgt ttctacgggt ctgttttcct tgtccgggaa ggcgagagct 933241 gctatggatt tcatcctgcc tgcaagcaaa acaaaggatg atcagtcatt gggagaattc 933301 ttccgcagac gtgtcggaga tgaagtggtc gagaacttaa tcgagccgct actatcaggg 933361 atctacgcag gcgacattga caagctcagc ctgatgtcga catttccgca attttatcag 933421 acggaacaaa agcatagaag cctgattctc ggcatgaaaa aaacaaggcc tcaaggctca 933481 ggccagcagc tgacggcaaa aaaacaaggg cagttccaaa ctctgtcaac cggtttgcag 933541 acccttgtag aagagatcga aaagcagtta aagctgacga aggtgtataa aggcacaaaa 933601 gtgaccaaac ttagccatag cggctcttgc tattcgctcg aactggataa cggcgtcaca 933661 cttgatgctg attcagtaat tgtgactgct ccgcataaag cggctgcggg aatgctttct 933721 gagcttcctg ccatttctca tttgaaaaat atgcactcca catccgtggc aaacgtcgct 933781 ttaggtttcc ctgaaggctc cgtccaaatg gagcatgagg gcacgggttt tgtcatttca 933841 agaaacagtg actttgcgat cacagcctgt acgtggacga ataaaaaatg gccgcacgca 933901 gcgccggaag gcaaaacgct gcttcgggca tatgtcggaa aagccggaga cgaatccatt 933961 gtcgatctat cagataatga cattatcaac attgtgttag aagacttaaa gaaagtcatg 934021 aacataaacg gcgagccgga aatgacatgt gtaacccgat ggcatgaaag catgccgcag 934081 taccatgtcg gccataagca gcgtatcaag gagctgcgtg aagcacttgc atctgcgtat 934141 ccgggtgttt atatgacagg cgcttctttc gaaggtgtcg gcattcccga ctgcattgat 934201 caaggaaaag ctgccgtgtc tgacgcgctt acctatttat tcagctaaaa cctccgcttt 934261 atcgcggagg tttttttgat gtgcaatggc aatattgtgt aaaaaatgat tgaattgaac 934321 agcaggttat gatacatttg catatgtact taatgactaa aatgttcaaa cggtcagttt 934381 cgaggtgaat acaatgtcaa tagatcgaaa aaagctcatt ttggaggcgg ctacaaagtc 934441 tttcacgcag ttcgggtata aagcgacgac aatggatctt gtcgcaaaac ttgcgaacgt 934501 ggggaaggga accatttata cttttttcaa aaacaaagaa gagctgtttg acgagatttt 934561 cactacttta ttaaaggaaa tgaagcaaaa agcggatgaa gcgatggagc cgagccttcc 934621 gttccatgaa aatgtgcaca gagcgctgtt tgccattctg gagttcagga aaacacatca 934681 gctgacgatt aaaattttcc aagagaatgc cgagattggt acaatggcag ttcaggaagt 934741 gatccagaaa atggagcgat ccatcctgtc ttatatcaaa agcaagattg aagacgggat 934801 caaaagcggc gcaatcaagc cgtgcgaccc tgagctgaca gcctttgtga tgctgaagct 934861 ttatatcgcg ctcatttttg actgggaaaa acaacacccc ccgcttgata aagagacaat 934921 tgcgggactg cttgaattgt atgttgtcaa aggattgtca gcgaactaga taatcctttc 934981 tctttgcaag aaaatgacca ttttttatga tgagtcagtt ttagaatgga ggcatcagga 935041 tgaacacaat acgaagtcag tggaaagaca tcgtaacaag taaaaaatta ttgattccca 935101 tcatcgccat tttgtttgtc ccgcttattt acagcggcgt attcttaaag gcttattggg 935161 acccgtacgg cacagttgac cagctgcctg tcgttgtcgt caaccaagac aagggagcaa 935221 cgtatgaagg agaaaaactt caaatcggtg atgatctggt caaagaatta aaggataata 935281 acaactttga ttggcatttt tccaatgatc tcgaccaatc gttaaaggac ttattgaatc 935341 aaaaatatta tttagttgtc gagattcctg aggatttttc taagaatgcc agcactgtat 935401 tagacaaaaa tccgaaaaaa ttggatctga aataccatac aaatgcaggt tctaactatg 935461 taggggcaac gatcggcgaa aaagcgattg ataaactgaa agcctctgtt tcaaaagaag 935521 tgaccgagca atatacgaaa gttatttttg ataactttaa agatatcgca aaaggtttga 935581 gcgacgcgag cagcggcgcg aaaaaaattg atgacggcac aaaggatgcg aaaaacggaa 935641 gcgcccagct gaaagaaaat ctggcgaagc tgaaggaaag caccgctacc atcagtgaca 935701 aaacagcgca gcttgcagat ggagcggctc aggtgacgag cggcatccaa tcacttgaca 935761 gctcgctcgg taaattccag gacagcagca accagattta tgataaatct agtcagcttg 935821 cagcaggatc aggcgagctg acaagcaaga tgaatgaact tcttgccgga cttcaaaatg 935881 tgcagaaggg tacgcctaat cttactaacg ggttggatca gctcaacagt aaagtccaag 935941 aaggttctga gaaagcggca aaagcggaaa agatcattaa tgcgctcgat ttaacgaagc 936001 ttgaaactgc tgtaaacaat ctggaaaagt cagaaactgc gatgaaggaa ttcaaaaaac 936061 agctgactga ctttgaaaac agtttgaaaa accgtgatca ggcatttaaa aatgtcatca 936121 attcgagtga cttcttaaca gcggagcaaa aaagccagct gattaattct gttgagaaaa 936181 agcttccgca agttgatgcg cctgattttg atcaaatatt aagccagcta cctacagctg 936241 atcagctgcc tgacatcgca acgataaaaa gctctcttga agacgtgaaa gcgcaggtgg 936301 cgcaggtgaa agccatgccg gaagctacat ctaagcttta taacggcgca aaaacaatcc 936361 aagatgcgat tgacagatta actgagggag ctgataagat atacaacggt tctcagaagc 936421 tgacagatgg ccaaactaaa ctgacagcgg gcatcggtga atataataag cagttcgcaa 936481 aagcaaaagc gggctcagag caattggtga caggaagcag ccaagtatcc ggcggattgt 936541 ttaagctgtt agacgggtct aaacaggtcc aaagcggatc atcaaaactt gcagacggat 936601 ctgcatcact tgatacaggt ttaggcaagc tattggacgg cacaggagag ctgtctagta 936661 agctgaagga tgcggctgac caaacaggag atatcgatgc tgatgatcaa acatacggca 936721 tgtttgcgga tccggttaaa accaaagatg atgccattca ttccgttcct aactatggaa 936781 cagggctgac accttatatc ctgtcaatgg gcttgtatgt cggcggcatc atgctgacgg 936841 ttgtcttccc gctgaaggaa gcgtcaggac gtccgagaaa cggttttgag tggttcttca 936901 gcaaattcaa tgtcatgatg cttgtaggaa tcattcaatc attgattgtg gcgacggttc 936961 ttctattggg aattggtctt gaggtagaga gcacgtggag attttacgtg tttacgatca 937021 ttacgagtct cgctttcctg gcgataattc aatttttggc tacaacgatg ggcaacccgg 937081 ggcgatttat cgcagtcatt attttagtgc tgcagctggg agcgagcgga ggaaccttcc 937141 cgctggaatt gcttccgaat ttctatcagg tcatccacgg cgcattgccg atgacctaca 937201 gcattaacgg attcagagca gtcatttcaa acggtgactt tggctacatg tggcagatgg 937261 ccggcgtctt aatcggcatt gccctcgtca tgattgcact aagcattact tactttacaa 937321 tgttaagccg gaaggaagaa acatcagaag aacagccggc ttcataaaga aaaagaactt 937381 gtttccttgg aaacaagttc tttttttgtt acatccccca tttaataagc aatcctgtat 937441 aggttaatcc gccgccaaac ccgaaaagca aaacgatttg atcttttttc agcttcccgg 937501 ctttcactgc gagatcgagc gccaaaacaa ttgaaaccga agacgtgttt ccgtagtgct 937561 caacactagt gagcgttttt tcaatcggga acggtgtttt ttcacaaatt gactcgatca 937621 tgcgcaagtt ggcgctgtga ggaacaaacc aatcgagatc atcggagctg agtcctgctt 937681 tatgtaaaag ccgttcaaat tcgccaggga cggttcttgc ggcccattta tatacctcgc 937741 gtccgttttg caccattttt ccggaaccga caagctgcac accgtttatt tcatttcgca 937801 gtccggcacg atacaaaata tcgccgccgt tcccgcttgt tccttgtaca gacgcaagaa 937861 atcccggcgt ctcttcatct cgttctacta acagcgcacc cgcggcatcg ccgaacagta 937921 cgcatgtcgt tcgatcggta taatcggtta cctttgataa cgtctctccg gcgatgacga 937981 gaattttttg atgaaggcca gatgtgatca atccatttgc caaatggagg ccgtatgtca 938041 gcccggcgca tgtcgcatta atatccagcg cgccggtgct ttcccagccg aaatattcct 938101 gtacgcggca tgccgtactc ggaaaggcgt aatcggatgt ggttgtggca acgaggatca 938161 tatcgacatc atcaagcgtt cctttataac ggctcttgag attcttcacc gcttctatgc 938221 ataaatcaga ggtaaattga tgttcatccg caatccggcg ttctctcatt cctgtgcgct 938281 gaacgatcca ttcatcagag gtatcaacga tcttttctaa atctgcattg gttaaacgtc 938341 tgctcggcgc ataggtgccg atagctgtaa tttttgcttt tgacatatga atcactcctt 938401 atggtcagat tataacacta gatattagta tctggtacta aaaagaaggt ttttttacaa 938461 aaaaagagaa gtgtagatag gaatctatga aaaagaaaaa ggaggctgaa aaatggtcag 938521 tcaagaagca gtagtctttt tggcattatc cggggctatt gcgtttctgt tgccaatcgg 938581 gctgattgta tggtttaagc gaaagtatgg tgcctcgctt aaagtgtttt ttattggcgc 938641 tctcacgttt tttgtcttcg ctcagctgct ggaaggcggc gttcatgttt atgtactgca 938701 agtgaatgaa atgacgaaag aagcgatgca gcatccatta tggtatggca tttacggctg 938761 cttgatggcc ggcatttttg aggagtgcgg aaggtatttg atgatgcgat tttttatgaa 938821 gcgccatcat acttgggcag atggtctggc tttcggggca ggccatggcg ggcttgaagc 938881 catcctgatt acaggcttgt cctctatctc acttattgta tacgcatttg caatcaatag 938941 cgggacgttt gaacagcttt tggtcaatgg cgacgtcaaa caggcgcttt tgccgataca 939001 ggagcagctg ctgcatactc cttcgtatga atggatgctg ggcggaatag aaagaatcag 939061 tgccattgcc gtccagattg gtctgtctct gcttgttttg tacgcggtta aaaaccgccg 939121 gccgctgttt ttgctgtatt ctattctttt acatgcactg tttaatgtcc cggcggtttt 939181 atatcaaaga ggaatcatag agcatgctgc agctgttgaa atcattgttg ctcttatagc 939241 ggctttatca gtttattgga ttgtaaaagc aaaaagggtg tttcaataaa aggtccaagc 939301 agcagcaatg cccgcttgga aaaatgtgaa tggaaatatt cattaagcat gggtcatcag 939361 aatatttctg attcagtctt tagcaatgac agcaagaatg tctgtgtttt ttacaagaga 939421 aacaatggtg tttctttttc ttcttctcgc aagggtcatg gcattctttc tttttcttgc 939481 aatggtcgtg gaaatcttta tcgaaccact cgtcaaagaa ccaaaaatca tcgaaccaat 939541 cgtgacaacg acatttctgt tcatgtgaat gacgacagca catagaaatc cctcctcttc 939601 ccatgctctc tacagcatat gagagattga taggaaaaga ttggacgggt ccctcgggaa 939661 aagagtatat tttaagtaga aaataaaagg aggaatgccc tatgacgtcc gtacgtaaaa 939721 cgatggagct cattaaagaa cttgtatcga tcccaagccc gacaggaaat acatatgagg 939781 tgatcaatta tattgaaagc cttttaaaag aatggaaggt agaaacggtt cggaaccaca 939841 agggcggctt aattgcaacg cttccaggac gcgacacatc ccggcatcgc atgctgacag 939901 cgcacgttga caccctcggc gctatggtga aggaaattaa agcggacggc cggctgaaaa 939961 tcgacttaat cggcgggttc cgctacaact cgattgaggg ggagtattgc caaattgaaa 940021 ccgcctcggg aaaaatgtac acaggcacaa tcttaatgca tcaaacgtct gtgcacgtat 940081 acaaagacgc gggaaaggct gagcggaatc aagagaatat ggagatccgc ctagatgaac 940141 ctgttcactg ccggaaagat acggaggagc ttggcattgg cgtcggagac tttgtgtcgt 940201 ttgatccacg tgtcgagatc acatcaagcg gatttattaa atcgcgccat ttggatgaca 940261 aagcaagcgt cgccttattg ctccgcttaa ttcatgaaat tcaaacagaa gacattgagc 940321 tgccgtatac aacccatttt cttatttcca ataatgaaga aatcggttac ggcgggaatt 940381 cgaatattcc tcctgaaaca gttgaatatt tggcggttga tatgggcgct atcggtgacg 940441 ggcaggcgac ggatgaatat tcagtatcaa tctgtgtgaa ggatgcgagc gggccgtatc 940501 attatcagct cagaaagcat ttagttcaat tagccgagaa gcatcatatt gactataagc 940561 ttgatatata tccgtactac gggtctgatg cgtcagcagc gatcaaatcc gggcatgata 940621 ttgtgcatgg cctcataggg ccgggaattg acgcttccca tgcatttgaa cgcacccata 940681 aatcatctct tcgccatacc gctaagcttc tgtattacta tgtacagtca ccaatggtat 940741 aagggggagg accaatgaag atttataagc tgaaaagcac attcggttgg gaaggtgatg 940801 acgggttggg agaacagctg attcagcaga tccttgccgg agaaaaaagc gccacgtgcg 940861 cgccgaaatc attgtattca aaagatgaat tgagggacgt ttatcaaaca gcgggtcagc 940921 ttgttaccgt ttatgataaa catgacaatc caagatgcaa tataaaagta acagatgtct 940981 ttgaaaccac ctttggtgcg cctgatatga ggttagtcaa aggagagggc aatggagacc 941041 gaattgagga gtttcaagag gatcatcgga tggcatgggc ggaactgatc aaaagcggtg 941101 aactggagct gaatgaggat actgttttga ttacagagtt gtttgtgctt gttaaagatt 941161 aaaaaagcct gcggggcaag aaccccgcag gcttttcatt aaccagaaat ggttgcgttt 941221 tgttctgttt tcgattggga cataacagtt tctgctttcg caggattaaa catgccttcc 941281 catttagaca tcacaacggc agcaagcgcg ttaccagtca ggttgacaac tgtacgtgcc 941341 atatccatga tgcggtctac gccggcaata aaggcaagtc cttcagccgg aacgccgatg 941401 gtgccaagcg ttgcaagcaa gacaacaaaa gaagtaccag gtacggcagc catccctttg 941461 gatgtcacca ttaagacgag cacaagcgta atttggtgcc aaatcgtcaa atcaatgcca 941521 tatacctgtg ctaaaaagag tgcggcaata gattgataga gaacggaacc gtctaagtta 941581 aacgtgtaac cgatcggaat gacaaatgaa acaatgcctt ttggacatcc gattttctcc 941641 attttttcca tgatacgcgg aagaaccgtt tcagagctgg acgtactgaa cgccagtaag 941701 atttcgtcct tcatgtaagc aaggaacttg aagatgctga tgccggcaat ttttgcgaca 941761 atcccgaaaa taacaattaa gaagaaagca agcgcgacat aaaccaatcc gacgagcttt 941821 ccgagagaga taagagaacc gagtccgaat ttagacacag tcactccgat aagagcgaaa 941881 acgccgaatg gcgccacttt catcacaagg tttacaacgt ggaacatggc atgggataca 941941 ccttcaaaaa aggctaatac aggcttgcct ctttcaccga tcgcggaaat acccaatgca 942001 aatagtactg taaagcagat gatggctaga agatcccctt cgaccaatga ctggaagaag 942061 tttgtcggca caatatggag gaacgtttcc gccactgatt tattactttg ttctttttca 942121 gtttcaacat attgactgat gtccgatttt tgagcttcgt gtatattaac tcctgtaccc 942181 ggatggaaga tgtttgcaag ggctagtccg agaataatgg caaaagtcgt gatgatctcg 942241 aagtacagaa tcgttctgaa gcctaattta ccgacttgct ttccatttcc tgcaccggct 942301 acaccgatga ttaagctgga gacaacaata ggaatcacta tcattttgat taagcgtaaa 942361 aagagatccc cgattggctg caggtaagta ggcaatgctg ggttgccata ccaaatgacg 942421 ccaacaatga cacctagaat aagtccaacg aatatttgtg tggctaatcc aaacttaatt 942481 cttttcatag attacctccc aaaaaacaaa gtatcaacat atatcatgaa tagacatata 942541 tttaatctca ctattagatc aaattataat agataagaaa tcaattcgtc tatagtaaat 942601 tatatttcga aaataaagaa tattcaatga cattatgata atcaccagaa ttatctaaaa 942661 acaggtgagc tttgacctaa cctgactatt atttcaaaat taagagatat gtgaaaaaat 942721 aagaaaatcc cacgcgtaag gcgcgggatt ttcgctcatt acaaatcgtt tacttttata 942781 cagtcattgc agatattacc ataacactca tgctgctctt ctatcttttt tccgcattcc 942841 gcacactttt tcgaaggcag gtttctaaaa aattctgtga ttttccccag cataaccaat 942901 ccctctttcc cctttgtagt gatttcattg taatataaca gattacaaaa atcaataact 942961 gttttgatac aatgtttaaa acatgctttt ttcaagaaaa atgggtatat tgaaggagga 943021 ccaatttttt tgaaaagata ggaggacatt atgaaagtta cagttatcgg atgctatggc 943081 ggttttccgg ccgcaaatga agcgacgtca ggctatttgt ttcagtcagg tgattactct 943141 ctgcttgttg attgcggcag tgccgtattg tctaagctgt tcggatatgt gccggcggaa 943201 aagctggatg cggtcgttct gtctcattat caccatgacc atatcgctga tatcggaccg 943261 ctgcaatttg ccaagcaagt cggttcgttt ctcggcaaag gagagcatac gcttccgatt 943321 tacggacatg atgctgatat agaacagttt caaaagctta catataaaac acatacaaaa 943381 gggatcgcct atcagccgga tcagccgctg actgccggtc cgtttacgat caccttttta 943441 aaaacgattc acccggtgac gtgctatgcc atgcggatta ctgacggcag ccacactgtc 943501 gtttatactg ctgattccag ctatcaggat tcatttatac cgttttcgaa agatgctgat 943561 ttattgatct cagaatgcaa tttttatgcc gatcaagacg gaacaagtgc aggccatatg 943621 aacagcctgg aagctgggcg cattgcaaaa gaagccggag cgggagaact gctgctgaca 943681 catttgccgc attttggcgt gcatgacaac cttcgcaaag aagcgaaaac cgtttttaac 943741 ggagaagtga atattgcgaa atcaggtttt gtgtgggaag gataaaggag gagcaccatg 943801 ttatttatag acaatcaaaa tatcaatgat ccgcggatca atcttgctat cgaggagtac 943861 tgtgtaaagc atttagaccc tgaacagcaa tatttgctct tttatgtgaa tcaaccgtct 943921 attatcattg ggaaaaacca aaatacaata gaagaaatca atacaaaata tgttgaggaa 943981 aacgggatta tcgtcgtccg ccgtttatca ggcgggggcg ctgtgtacca tgatctgggg 944041 aacttgaact tcagctttat taccaaggat gacggggaca gctttcataa ctttaaaaaa 944101 ttcactgagc cagtgattca ggcgttacat cagcttgggg ttgaagccga attaagcggc 944161 cggaacgaca ttgtagtaga tggccggaaa atatccggaa acgctcagtt tgcaacgaaa 944221 ggccgtattt tcagccacgg caccctcatg tttgattcag ccattgatca tgttgtatca 944281 gcattaaagg tgaaaaagga taaaattgaa tcaaaaggca tcaaatcgat cagaagccga 944341 gtggcaaaca tcagtgagtt tctcgatgat aaaatgacca ccgaagaatt ccgcagccat 944401 ttgcttcgcc atatttttaa cacaaacgac gttggaaacg tgccggagta taagctgacg 944461 gaaaaagatt gggagaccat tcatcaaatt tcgaaagagc gctatcagaa ttgggattgg 944521 aactacggcc gctcaccaaa atttaacctt aatcattcga agcgttatcc ggttggatcg 944581 atcgatttgc acctggaagt caagaaaggc aaaatcgagg actgcaaaat cttcggagat 944641 ttcttcggtg tcggtgatgt atctgaaatt gaaaacctgc tggtcggaaa acaatacgaa 944701 cgcagcgtca tcgctgatgt gctcgaaggt gtgaatctca agcattactt tgggaacatt 944761 acgaaagagg atttccttga tctgatttac taaggcaaaa cacatcgttt gaaagagcgg 944821 ttgtgttttt gaaataatgg aggcaggagg gattcacatg aaagtgtttt taatcggagc 944881 gaacggacaa atcgggcaaa gactcgtctc tttattccaa gataatcctg atcattccat 944941 cagagcgatg gtcagaaaag aagaacagaa agcgtctctt gaagctgccg gtgcagaagc 945001 tgtgcttgcg aatctggagg gcagcccgga agaaatcgcc gctgcggcaa aaggttgtga 945061 cgcgatcatt ttcacagccg gttccggcgg cagcacaggc tatgataaaa cgctgctggt 945121 ggatcttgat ggagcggcaa aagccattga agctgcggcc attgccggaa tcaaacggtt 945181 tattatggtc agcgccctgc aagcccataa ccgtgaaaat tggaatgagg cactcaagcc 945241 ttattatgtg gccaagcatt atgctgataa aattctggaa gcgagcggtt taacctatac 945301 gattatccgt ccgggaggcc ttcgcaatga gcctggaacg ggaactgttt cagcagcgaa 945361 ggatctggag cggggattta tttcccgtga tgacgttgca aaaacggtca ttgcctcttt 945421 agatgagaag aatacggaaa atcgggcctt tgatctgaca gaaggagata cgccgattgc 945481 cgaagcattg aagaaactat gacagtactg acactcaggg ctttttgctc ttgagtgttt 945541 ttttctgttt ctctataatg gagaagaaag cttggcttca ataatgaatg actattcatt 945601 cacttaaggg gtgggagaat gaatcttgtt tcaaaattgg aagaaacagc atctgagaag 945661 cccgacagca tcgcatgcag gtttaaagat cacatgatga cgtatcaaga gctgaatgaa 945721 tatattcagc gatttgcgga cggccttcag gaagccggta tggagaaagg ggaccattta 945781 gctttgctgc ttggcaattc gcctgatttt atcatcgcgt tttttggcgc tttaaaagct 945841 gggatcgtag ttgttcccat caatccgttg tacacgccga cagaaattgg ttatatgctg 945901 acaaatggcg atgtaaaggc aatcgtgggc gttagccagc ttttgccgct ttatgagagc 945961 atgcatgaat cgctgccaaa ggttgagctc gtcattttat gccagacggg ggaggccgag 946021 ccggaagctg cggacccaga ggtcaggatg aaaatgacaa cgtttgcaaa aatattgcgg 946081 ccgacatctg ccgctaaaca aaaccaagaa cctgtacctg atgataccgc ggttatttta 946141 tatacgtcag gaacgactgg aaaaccgaaa ggcgcgatgc tgacacatca gaatttgtac 946201 agcaatgcca acgatgtcgc aggctatttg ggaatggatg agagggacaa tgtggtctgc 946261 gctcttccca tgtttcacgt gttttgttta accgtctgta tgaatgcacc gctgatgagc 946321 ggcgcaactg tattgattga gcctcaattc agtccggcat ctgtttttaa gcttgttaag 946381 cagcagcagg cgaccatttt tgccggtgtg cctacaatgt ataactactt gtttcagcat 946441 gaaaacggaa agaaagatga tttttcttcg atccggctgt gcatttcggg aggcgcgtcc 946501 atgccagtcg cgttgctgac ggcgtttgaa gaaaaattcg gtgttaccat tttggaaggc 946561 tacgggctct cggaagcatc acccgtcacg tgctttaacc cgtttgacag gggcagaaag 946621 ccgggctcca tcgggacaag tatcttacat gtcgaaaaca aggtcgtaga tccgctcgga 946681 cgcgagctgc ccgctcacca ggtcggcgaa ttgatcgtga aaggccccaa tgtgatgaag 946741 ggctattata aaatgccgat ggaaacagag catgcattaa aagacgggtg gctttatacg 946801 ggggacttgg caagacggga tgaggacggc tatttttaca ttgttgaccg gaaaaaagac 946861 atgatcattg taggaggata caatgtgtat ccgcgggagg tggaggaggt gctgtacagc 946921 catccggacg tcaaggaggc ggttgtcatc ggcgtgccgg acccccaaag cggggaagcg 946981 gtaaagggat atgtggtgcc gaaacgctct ggggtaacag aggaggacat catgcagcac 947041 tgcgaaaagc atctggcaaa atacaagcgg cctgccgcca ttacgtttct tgacgatatt 947101 ccgaaaaatg cgacggggaa aatgctcaga cgggcactga gagatatttt gccccaataa 947161 aatgaaaaag cgaagcggtt agcttcgctt tttcattttc aatcctttgc ttctttttta 947221 ataatattta gcagcgcctt tgtatcattt ttgcttaatt tgtagtatgt gccatccttc 947281 aaaaaaacgg cttgctggct gccgtcaatc catagtctga atgagtcata ccggtcttta 947341 tgaaacttga ttgtcccttc gtaatcaggg gctgatgttt tttctgtctt cacctgtttt 947401 ccctgattca taatatccag catatctttg acgtgctgtc ttttttcaat ctcgatatct 947461 tcctggccgc ttgaagacag tgtgatcaaa tccgcgtcta ccgattgata cacatcgcct 947521 gatcggctgt aaagataaaa aaatgcgata aacacaagac cgattaccac gatggctgcc 947581 actatttttt tcatttgcat cactccaaac attgttagtt ttcccagcga tcggggtttc 947641 catgcttaaa agggtggaaa agtgcggaac acagcttggt tctaagaatt tgaatttatg 947701 attacaatag aagtaacggg ttgatgtgag gagtgaggcg ttatgcgcaa gtggattgcg 947761 gcagcaggac ttgcttacgt gctgtacggg ctgttttttt attggtattt tttcctgtcg 947821 ggtgattccg caataccgga agccgtgaaa gggacgcagg ctgatccggc ttctttcatg 947881 aagccgtctg agttggcagt ggccgagcag tattcgaatg tcaagaattt tttatttttt 947941 atcggggtac cacttgattg gtttctgttt tttgttctgc ttgtcagcgg tgtttcaaag 948001 aaaatcaaga aatggatcga agcggccgtg ccttttcggt ttttgcagac cgttggtttt 948061 gtgtttgtgc tttcgctgat tacaacattg gtgacgctgc ctttagattg gataggctat 948121 caagtatcgc ttgactataa catttccaca cagacaacgg ccagctgggc taaggatcag 948181 gttatcagct tttggatcag ctttccaatc tttacgcttt gcgttctcgt tttttattgg 948241 ctgatcaaaa ggcatgaaaa aaaatggtgg ttatacgcct ggctgttaac agtgccgttt 948301 tcgctgtttc tgttttttat tcagccggtc attatcgatc ctttatacaa tgatttttat 948361 ccgctgaaaa acaaagagct tgaaagcaaa attttagagc tggcagatga agccaatatt 948421 ccggctgacc atgtatatga agtgaacatg tcagaaaaaa caaatgcgct gaatgcctat 948481 gttacaggaa ttggggccaa taaacggatt gtattgtggg atacgacgct gaacaaactt 948541 gacgattcag aaattctgtt tattatgggc cacgaaatgg gccattatgt catgaagcac 948601 gtttacatcg gtctggctgg ctatttgctc gtgtcgctcg ccggatttta tgtcattgat 948661 aagctttaca agcggacggt tcgcctaacc cgcagcatgt ttcatttaga agggcggcat 948721 gatcttgcgg cacttccgct gttattgctt ttgttttctg ttttgagctt tgcggttacg 948781 cctttttcta atgctgtctc gcgttatcag gagaataagg ctgaccagta tgggatcgag 948841 ttgacagaga acagagaagc cgctgttaaa acgtttcagg atttggccgt gacggggctg 948901 agccaggttg atcctccggt gcttgtgaag attttcagag gcagccatcc gtcgatcatg 948961 gaacggattc aacatgcgga gaaagaagag aatgcgccgg aacatcagga tgctgacaaa 949021 taaaaagaag caggtatgga ggaacctgct tctttttact attattgtgc agctgcttgt 949081 acgttgatta acccttttcc atagtagaaa gagtttccaa gatatgttgc agtgctttct 949141 aaacgatcac ggacttgcgc gtttgtccaa gtcgggtgct tagaaagaat taacgctgct 949201 gctccggcaa cgtgaggagt cgccatggac gttccgttat aagcgccgta agtgcctcca 949261 ggaagtgtgc tttggatgga cacgccagga gccatcacat caagctcaga acctgcgctg 949321 gagaatgaag ctctttggtt gctgctgttt accgcaccta ctgcaatagt agaaggatat 949381 tttgcagggt agccgactgt gcttgtgctt ccggatgaac cttcgtttcc ggctgcggca 949441 gcaacgacga taccgctgga aacggctttg tcaacgactg ttttcagcgc tgtagaacca 949501 gtaggtccgc caaggctcat gttgataaca tccatattgt tggaaatggc ccactcaatg 949561 ccgttaataa tccagctata ttggccgctt cctgttgaat caagcacttt tactgcatat 949621 aatgatgcgc ttggcgctac gcccagaaca ccgattgagt tattaagagc ggcaatcgta 949681 ccggctacat gcgtaccgtg agaactgccg tcctggtatg ggtttgtttc agaaggtacg 949741 aagcttgctc cgcctctgac gtttaagtca ggatgagaag agtcaattcc gctgtcgata 949801 acagctactt ttacgttaga gcctgtgtag ccttgagagt gaagagccgg cgctttaatt 949861 tgagaaatgc cataaggaac agattgcgca tattcatgtg caatatgatc ttcttccaca 949921 tatgcaacgc tcggatcttt tttcaattct tttacagctt tttcatccaa tgttgctgcg 949981 gccgcgttaa catacttaaa ttgcttttga acctttccgc ctttttcaga aataacatcc 950041 tttttcttgg cggaactcat ggcactcatt gtctgtttaa atccgacaat gtatttcttt 950101 tctgtactgc tttttccggc agcctgcgca gacatgttgc tgaacgccat cgtaaagatt 950161 aacgttaacg caaacaacaa gctgatccac aattttttgc ttctcactct ttaccctctc 950221 cttttaaaaa aattcagagt agacttactt aaaagactat tctgtgaatt tattgtaata 950281 gatggaataa tattttagta gacccatttt tttgagatga ttttatctct atttaggtat 950341 atcatctctc gctatttccg tagagactcg aaataactat tttcatacag aaaagaacga 950401 aaatagacat gagtaaatgt tcattatgct gaaatgtcat gcttttttag gttaaatgct 950461 cctgagtccc ggcaaattcc tgtcgaaaaa attcgttcaa atgacctgcg tgtgcttccg 950521 tgagaacaat ggatattatc gtgatatttt ttcaaagcat gatgataaaa gtattctgaa 950581 aaataaactt tacagaaaag ggatagaatg aaaaaattat tgagagggag gaagaaataa 950641 gatgaacatt cgccaagcaa agacatcaga tgcggccgcc attgcgccgc tgtttaacca 950701 atatcgggaa ttttatagac aggcatccga tttgcaaggg gcagaggctt ttttgaaagc 950761 tcgtttggaa aatcacgagt ctgttatttt gatagcagaa gaaaatggag aattcatagg 950821 ctttacccag ctctatccaa cgttttcttc tgtgtcaatg aaaaggatat acatattaaa 950881 tgacttattt gtcgttcctc atgcgcgtac aaagggagcc ggcggccggc tgctttctgc 950941 cgcaaaggat tatgcagggc aaaacggggc aaaatgttta acacttcaga ctgagcacca 951001 caaccggaag gcaagaagct tgtatgagca aaacggctat gaagaggata ccggatttgt 951061 ccattattgt ctcaatgtgc cggcgaagtg aaaatggcgg cttgatgatt tggttttttg 951121 aacgttcttc ggttacgata taaatgaaaa ggagtgtgcc gaatgtcaac gttatttcaa 951181 gccttgcagg cagaaaaaaa tgccgatgat gtttcagtcc atgtgaaaac catatcaaca 951241 gaggatttgc cgaaggatgg tgtcctgatt aaagttgctt attccggcat taattacaaa 951301 gatggtctgg ccggaaaagc aggaggcaat atcgtcagag agtatccgct tattttaggc 951361 attgatgctg cgggtacggt cgtctcttcc aatgatccgc gttttgcgga gggggatgag 951421 gtgatcgcga caagctatga gctcggtgtc tcacgtgatg gcggattaag tgaatacgct 951481 tcggtgcctg gtgactggct ggtgcctttg ccacagaatc tttcgttaaa agaagcgatg 951541 gtgtacggaa cggcgggatt tactgcggcg ttatcagtgc atcggcttga acagaacggt 951601 ctgtctccgg aaaaaggcag cgtgctagtc acaggagcaa ccggcggtgt cggcggaatt 951661 gcggtatcga tgctgaacaa gcggggttat gatgtggtgg caagtaccgg aaaccgggag 951721 gcggctgatt atttgaaaca gcttggtgca agcgaagtaa tcagcaggga agatgtctat 951781 gacggaacgc ttaaggcgct gtccaagcag caatggcagg gagcggttga tccagtcggc 951841 ggaaaacagc ttgcctcgct tttaagcaaa attcaatacg gcggatctgt cgcagtgagc 951901 ggcttaaccg gcggaggaga agttccggca accgtgtatc cttttattct tcgcggagta 951961 agcctgctcg gaatcgattc agtatattgt ccgatggacg tcagagccgc tgtttgggag 952021 cgcatgtctt ctgatctcaa gcctgatcag ctgctgacca tcgtggacag ggaagtatca 952081 ttggaagaaa cgccgggtgc gttaaaagat attttgcaaa atcgcattca aggaagagtg 952141 attgtgaagc tttaacagga tcagcttgca gagaatgtta tttttctgca agcttttttg 952201 tggacaggat gatcagctgc tgaactgctg tgtcgcgaaa caagattttc ctgtaagccg 952261 aactttctct tctcatttta aaaataattg gtgataatga ttctcattcc gtgttatact 952321 actcttggac atcttaacca tagaaactac caacaggaga gactggaaca tatgaaaaaa 952381 acactgatta ttcttacagt tttacttctt tctgtcttaa cggctgcttg ctcgtcttca 952441 agcggcaatc aaaacagtaa agaacataaa gtggcggtaa cacatgattt agggaagaca 952501 aatgtgcctg agcatccgaa gcgggttgtt gttcttgagc taggttttat tgatacactg 952561 cttgatctcg gcattacgcc tgtcggggtt gccgatgaca acaaagcgaa gcagctgatc 952621 aacaaggatg tgctgaagaa aattgacggc tacacatctg tcggcactcg ctcacagcca 952681 agcatggaaa aaatcgcttc attaaaaccc gatttaatta ttgctgacac gacccggcat 952741 aagaaggtgt acgatcagct gaaaaaaata gcgccgacga ttgcacttaa taatttaaat 952801 gctgattatc aggatacaat tgacgcttcg cttacgattg caaaagcagt cggcaaggag 952861 aaggaaatgg agaaaaagct gacggcgcat gaagaaaagc ttagcgagac aaagcagaaa 952921 atcagcgcga acagccagtc cgtgcttttg atcggaaata caaatgatac cattatggcc 952981 agggatgaaa acttctttac atcgagactt ttaacacagg tcggctaccg atatgcaatc 953041 agtacgtcag gcaatagcga ttcaagcaat ggcggcgact ctgtgaatat gaaaatgaca 953101 ctggagcagc tgctgaaaac agatccggat gtgatcatcc tgatgacagg aaaaacagat 953161 gacctcgacg ccgacggtaa acgcccgatc gaaaagaatg tcctttggaa aaaactgaag 953221 gcagtgaaaa acgggcatgt ataccacgtg gatcgtgcgg tgtggtctct gcgccgcagt 953281 gtagacgggg cgaatgccat tttggacgag cttcaaaaag agatgccggc tgctaagaaa 953341 taaaagaaaa gacaggcaaa cgcctgtctt tttcttattt gataaagccg gataagtggc 953401 tgttgatatt atagtctttt atccgccatt tttcttctgc aaattcaatg ttgctgaggc 953461 aggcgttgac gagacgggtg ctttgaagct ccgggtcacc gccggatatt tctgtcagca 953521 gggcgtgaat tgccgcaccg tgcgccacga tcagcacctt cttgtttgga tacgcctgat 953581 tcacttttgc caaaccgccc atcagcctgt cagtgagttc ttctaaggtt tccatattcg 953641 gatagatgtt atctggatag cgctttgtcc gttcctccag cggcatgccc tccgcgtcgc 953701 cgtaatcgcg ttccttaaaa tcatccatct cgactatcgg aagatgcaga tattcattaa 953761 taatttccgc ggttcttttc gctcttttca gcgggctcgt cacaataata tcccaagaaa 953821 agtcctttac atattctccg gtttctcttg cttggcgttc acctgttgcg tttagcggga 953881 tatcggtttt gccttggcat ttttgctgca ggttccaatc ggtttctcca tgtcttacta 953941 aacaaacggc tgtcataaaa tccccttcct gactttattc atatcgctat tatactaaat 954001 cgaaagcgtg tgtcctatga aaaagcctat gcaagaactt caaataataa agccagtccg 954061 attccgccgc cgcttccgat ggctgcaaca gcatattgac agtctggccg tcttttcgct 954121 tcataaaaca atctggttac cagagctgca cctgatgcac cgtacggatg gccaagagct 954181 aaggcgccgc cgcgcacatt gatttttgaa aagggaatgc cgagttcttg cgagcagaca 954241 caaattttga cggcaaaggc ttcattgatt tcaaataaat cgatatcatc aggtgttaca 954301 tcgtgtgtat gtaagagctg acgaatcgcg acaaccggtg ccgcgggcgg aaagttgggg 954361 tgaatgccgc tgacagcgct gccgataaac cgaagcacag gcttaagtcc cagggctgct 954421 gctttttctt cttccattac caaaagagcg gctgctccgt ctgctatgcc actgctgttg 954481 gctgctgtga ctgttccgga gctggtgtcg aaaaccggct ttgcacgggg aataatcgct 954541 tctattggcc gcgttttcaa aaatgcttcg tccgtctcca attccccgag agcaacaact 954601 tcttcacggt aaaatccttc atcatgcgcg ttcctgctgc gttgatggct gagaagcgcg 954661 tactcatcct gcatgcttct gctgatggaa tagcgtgcag ccgtatattc tgccgcaatg 954721 cccatgtctg gatcgccgat cgcatctgga gaaaagcgag cccgttctga aaaaggggat 954781 tggctgctgc tttctgagcc gcccgcgata tacatcgtgc cggctcccgc ttgaataagg 954841 ctgcaggcat agcgcacagc ttcaaggccg gagccgcact gtctgtcaat tgtcattccg 954901 ggaaccgata aaggcagtcc ggcttgaagg gctgacagtc tggccaggtt gccgcctctg 954961 ccagtagcgt ttccgagaat gacctcgtca acttgatcct ctagctttcg gctgagacag 955021 cggatgatgg gagccgccaa atcctccggc aggaagggct tcagcagtcc gttttgattt 955081 ccaaagatcg ttcgttttgc atcaacaata accgcattca tttatactgt acactctctt 955141 ccagccattt tttcactctg gaacgggcaa tttttccgct gctcgtttcc ggcaagctgt 955201 ctgcaaacac ccattttttc ggaattttat aggaggctaa tttctgttta caccaggctt 955261 tcagtgttct ggcattagcg tttccaagaa tgacagctac agcgatttct ccccaatact 955321 cgtcgggaat gccaacgaca gccgcgcttt caacctctgg gcaggcgaga agcacacgtt 955381 caatttcttc tgggaaaata tttaatcctc cgtacacgat catcccgttt tctcttcctg 955441 atatgtatag aaagccctct tcatcaacgt agcccatatc atctactgtc atccattcat 955501 ctggtgtgct gccgttcaca tagccggaaa acctcatcgg gcttttgaca aatatttttc 955561 cgatttctcc tggctggcag cgttctcctc cagcgttgcg gatttcgatc cggacattat 955621 gaaaagggcg gcccgctgaa tgcggcttcc gtttgctgtc ttccggtgaa gaaaacgtca 955681 caaaactaag ctctgatgtg ccgtaaaaat cgtacagctt gagatgaggc catgcagcgg 955741 caagcttctt cttggattct gccggccagt ctgcgccgga tgaaatgatt ttgacgggac 955801 tgtcgggaaa accctcaatc cttgcgaggg cgtctgtcat cgtcggtacg gtatagagaa 955861 cactgatgga ttcacggcac agccattcct tcgctttggc aggagaaaac tttttcagca 955921 aacaaacggt tcctccgaga aacaaagtgc tgacagcccc atataggaag tgagaggaca 955981 ttaacgctcc gggaatcaga accttatcat ctgatgaaat cgaaaaatct gtttctgtac 956041 aggtaaagct ctccatccat gagcggtgag atcgcgtaaa ggccttcggt tttcctgtcg 956101 agcccgacgt aaatcccata taaaaagggt gctccggatc aatggtaggc aagggatcag 956161 cggctgcctc agaaatatct gccatacagt tatccagcaa tacaacaggt gtctggctat 956221 ctgtcagttt gtttttgaaa aaggctaaag taaccacaag atccgcattg cttatggaca 956281 gccgctcctt acattcagcc gggctccagc gtgtgtcgat gggaatggcc gtacatccag 956341 ccgctgcggc tccggcaaac agctgtaaaa acgcgagact atttgggagc aggatcgcca 956401 cacgattcgg catgctcggc tgtgaccgca gccaatttgc ggtttgagag acaagccgat 956461 cccaatcatg gtacgtgatt tgctccgatt cagtctggat cgctacacgg ccgggcgatg 956521 tttcggcagt agatgaatag gtatgagtaa ttgtcatgta ttgtcatcct ccttttgtaa 956581 acatcgtatc agaaagagac aaggcttgag tgatttttat cgccagaaat gcagatacag 956641 ccgcttttat caaatcacca ggcacatatg caaggctcat gaaggcggcc tgtgacaaat 956701 caatatgcat gataaaagct tgtaccggta taccaagcag ataaataaag atgatgccga 956761 atacgatatg agtgaaaaag agacgcaata ctgtcacctt ccgcagcctg ttagcggcta 956821 aactgatcag ccatgaagcg aggggataag caatcaaaaa gcctgcgctc ggtccgaaaa 956881 acacaccaaa accgcctcgt ccgccgggca acagcggcgc tccgaaggcg acgagcagca 956941 aaaagacaag ctggcttaag aaagcagact ttggcctgag aatgctgcct gccaacatga 957001 caccaagcgt ttgcaatgta atcggaacgg gtgtaaagga taagaagaga gggggcataa 957061 agccgagcac tgccatcagc gcggtgaaaa tcgcaatatg catcatgtcg attaatttca 957121 gcatgtgaaa tcctccaaaa agtaatcaaa tatggttata caataaatgc aggtaattat 957181 tatgtcaact gatttttaat ttaagtttac ataatgaacg caaaaaaacc ggccgtatgg 957241 cagaccggtt tttgatggtt attcttctgt caggatgaca agcgaatcaa cggaagcggc 957301 cacatgggaa acggcgcggc tgacttcctg aagccctcca agaaaggctt gcagatcgac 957361 gtcgattttg cctgattgct ctttgctgat tttcatgctg tggacgattt catcgaataa 957421 gcggttaatt tgcgtcattt tttctttact ttcgctgact agctcattca cgtctttgat 957481 atgcttggat acaatgttga tttgtgtatt cgtattgttc acaagctcag aaacagtaga 957541 gacggttttt ttcgtatcct cagaaagctt ccgcacttca tttgccacga cagcaaagcc 957601 tttgccgtgt tctccggcgc gggcggattc aatagatgca ttgagcgaga gaaggtttgt 957661 ttgttcagct atgcctgtga cgatgccgaa gattttttca atttgctgcg cgatttcatc 957721 cagcttgacc atttcttttt cgatttggac aaggcttgtg tcaattttgt tcatctgttt 957781 ttgctggact tctagctctt tttttccgcc gatcgacttt tcttcaacag tgctggatgt 957841 tacagtgccg gctttggatg cttgagaaat gccttcagat ttgtccacaa gctcttgaac 957901 tgatctgctt gtttctgaaa acagattggc aatcgatcca gaggtttctt gaattttctg 957961 atgaagaagg tttttctttt cttcttgttc atcacgggtc tggttgtact cgctttgaaa 958021 cgcttcaagg acaagctgct gttctaagtt caagattttt gttgttgctt taatggcttt 958081 tagcagttct tgctgatttg taatggacgc ttcataaatg tcaatcattg acaaaaggag 958141 ctcttgaaac gcacccatat accattttgg caaaaggccg attcttaaat ggatggaggc 958201 gattcggtta cgcttttcaa taaattcatc atcgataacg cctgcaaaca tttcctgaat 958261 atgccgtttt aacgtttgtt ttaagcggtc aactgagctg tgatcattaa tgatatccat 958321 caatgagctt tcatggtcaa ggtttttata aaacgcatcg acgatattta cgatattttc 958381 ttgaatgagt ggctgaagct gctctaacac ataaagctca gcatctccca acctgaccat 958441 tttgagctgt tttttgacat ctgcatgttt gtttgtgagc tgaatgcggt ttttttgttg 958501 tccgtttgaa tctgaaaagt aagctgtttc ttgttttctg tcttttttaa ataacaatac 958561 aatgatcccc cttgggaaaa atataatttt tactttttgg ctttttaagc ctttttcttt 958621 tttatcggcc aagggaaaca tgaatgaagc tgcagatgaa aaatatttga aaaaacgttc 958681 attaaaatga acggtttaat cgagatctat ttgttttaat ggtttaatgg ccggaccctc 958741 tacaacttcg ccagatggct taaagcgtga tccgtggcac ggacaatccc acgtatgctc 958801 actgtcgttc cactcgacct cgcagcctaa atgggtacaa gtcgtatcaa cgagatggag 958861 gcagcctgtc tcatcacgaa atgctcccgc tcgcctgccg tttatggtga cggctttccc 958921 ttctcctggc gaaatgtctt caaattggac atcaggcttt tcaagctttc cttttatcaa 958981 atgcttggcg acatctgcat tgtaggaaat cactttctgc aacccgggat tcagatggaa 959041 acgggacggc gtgaaaatgc tttcgtatgg gttttctttt ttctccacaa ggtctgacaa 959101 taaagtggct gcgactgctg aggacgtcat gccccatttt ttgaacccgg tcgctactag 959161 aatattgtcc tcattttccg acatcggccc gataaacggg attttgtcga tcgtcactag 959221 atcttgggtg gaccaataat atggaatgct ttcgatgccg atggtgcttt cggccagttg 959281 tctcagtgtt tcataatgtg tagacatggc ttttccctgg cctgttttat ggcttactcc 959341 gctgaagaga atcagctttt caccgtttac aaccgtatag cggagcgcca ctgacggctg 959401 atcgatactc aaatacatgc cctcgggata ctcgatcttc ggcttgatgg caaggacata 959461 agatctgtcg gagtacattc tcgcagcata taatccgcct ccgtcataaa aagggaagtg 959521 ggaacagcat atgataaagc ggctcttaat ggcgtgccgg ctttttgtta ccacttcggg 959581 cctttcgcct tttttgatat caagcgcaac ggtctcttca taaattcggc cgcctttttg 959641 aacaatttgc tccagaagcg cttttaagta ttgaagcgga tgaaattgag cttgattctt 959701 catgacaagc gccagcttag aacctaaggg aattggaaga tccttgataa ggtctctttc 959761 aattccgagc tttgtgtatg cctcatgctc ggtgtggatt ttttgaacag cgttttcatt 959821 tgccgtataa agatatgcgt cttgctcgat ccattcacaa tcaatttgat gttcatccac 959881 aatgcctttt atgtaatcaa ttgcgttttg gtttgcttca taataaagcc tcgcatggtt 959941 taatccgaaa tggcggataa attcgtcgta tatcatgtca tgctgtgcgg taactttagc 960001 agttgtatgc gcagtggttc cgttaagaac ctgatttgct tcaatcaaaa cgacacggaa 960061 gcctctcttc gtaagttcat atgccgttgt gattcccgta atcccgcctc cgataatggt 960121 gacgtcacat tcagtgtcct cttgaagcgc aggaaaagaa ggcaggtcag ttgatgtttt 960181 ccagtatgtt tcaggtgctt cctttgcaaa atgttgatta gccaagccgt tatacctcca 960241 atcagattta ttcttaattt ttccatattc tatcttttca tacataggaa gcaggcattg 960301 ttcataacat aataaggttg aaaaggagtg atttcattgg cgaatcaaaa aaagaaaaca 960361 ttaccgcctc agcaccagaa ccagcagcct ggttttgaat atctgatgga cccgcgtccg 960421 gtttttgata agccgaagaa agcgaaaaaa ttagagggca aaaccgctat tattactgga 960481 ggagacagcg ggattggacg cgctgtctcg gtgttattcg caaaagaagg ggctaatgtg 960541 gtcattgtgt atttgaatga acatcaggac gccgaggaaa caaagcagta tgtagaaaag 960601 gaaggggtaa aatgcctgct gattgcagga gatgtcgggg atgaagcgtt ttgcaatgat 960661 gtggtcgggc aggcaagcca agtgtttcca tccattgata tattggttaa caatgcagct 960721 gagcagcatg tccagcccag cattgaaaaa atcaccagcc accagctgat cagaaccttc 960781 caaacaaaca ttttttccat gttttactta acaaaggcag tgctgcctca tttaaaaaaa 960841 gggagctcta ttattaatac cgcttcaatt accgcctata aaggcaataa aacgctgatc 960901 gattattcag cgacaaaagg cgcgatcgtt acgtttacaa ggtccctttc ccagtcgctt 960961 gttcagcagg gcatacgggt caatgcagtg gcaccgggtc ccatttggac accgcttatc 961021 ccggccagct ttgccgcaaa agacgtggaa gtgtttggtt cagacgtgcc gatggaacgc 961081 ccggggcagc cggtcgaagt ggcgccaagc tatctatacc ttgccagcga cgattccaca 961141 tacgtcacag ggcagacgat tcacgtcaat ggcggaacaa ttgtgaacgg ataataaaaa 961201 gccaatcctt gaaggattgg cttattcgct ctgcttgagc gctgcatatt ctttagagag 961261 cgtaagaaac gcatctttat ctttttcgtc caaggctttg ttaatttggt ccgtcagcat 961321 ggcaagccga cggttataca aggattcatc gagcaccatt tgaatgtaaa tatccgtcat 961381 tgtgacatcg aattcttttg ttttttgcgt gttgcgggac ttcatgagct cagtgtacga 961441 ttttttctct ttcataaaga atccccccaa tgcctttttt atagtatatg gataacggtc 961501 gaaaaaatca ataaattttt ataattttta gacaactaat acttggcaat ctatcgacat 961561 atcctgcaaa atgccgtaaa ccggcaagtc ttatgaaagt aaaatcggtt tattactagt 961621 catttagtac cattaaatat cattaaaaga tgattttatc ttaaatgtta aaaaaacctg 961681 tcgttttaca aaaacagatg atagattatt agtataaatt ttgcagaaaa aggatggagg 961741 ccataatatg agtcagaaaa cagacgcacc tttagaatcg tatgaagtga acggcgcaac 961801 aattgccgtg ctgccagaag aaatagacgg caaaatctgt tccaaaatta ttgaaaaaga 961861 ttgcgtgttt tatgtaaaca tgaagccgct gcaaattgtc gacagaagct gccgattttt 961921 tggatcaagc tatgcgggaa gaaaagcagg aacttatgaa gtgacaaaaa tttcacacaa 961981 gccgccgatc atggtggacc cttcgaacca aatcttttta ttccctacac tttcttcgac 962041 aagaccccaa tgcggctgga tttcccatgt gcatgtaaaa gaattcaaag cgactgaatt 962101 cgacgatacg gaagtgacgt tttccaatgg gaaaacgatg gagctgccga tctcttataa 962161 ttcgttcgag aaccaggtat accgaacagc gtggctcaga accaaattcc aagacagaat 962221 cgaccaccgc gtgccgaaaa gacaggaatt tatgctgtac ccgaaagaag agcggacgaa 962281 gatgatttat gattttattt tgcgtgagct cggggaacgg tattagaaaa ataggaagga 962341 gctgaccgaa cagggcagct cctttcataa agctatgccg tcggaattcc tccggtgatg 962401 ccatatacct gagatgtcac atagcttgaa ttctctgaag ctagaaatac ataaacatcg 962461 gccaattcca ctggctgccc agcgcgattt aatggagctg gcggcgtgcc ttgtccgaat 962521 ttcgggatgt tttccgtcgg ctgtccgccg gaaatttgca gcggtgtcca aattggtccg 962581 ggcgcaactg aatttactct gatgcctttg gaagcaagct gttttcccag tccgacggta 962641 aagccgataa tggcgttttt cgttgctgcg taatctaaca gcatcgggct tggattatag 962701 ccttcaactg aggtagttgt gataattgaa gctccctccg gcaaatacgg aagcgccgct 962761 tttacaaccc agtaaaggga aaagacgttc acttcaaatg ttttatagat ttgttcagta 962821 ggcagatctt cgatgttttc gaccgcttgc tgtttgcctg caacgagcgc tagcacatca 962881 agtccgccga gttcgtgatg cgactgtttg actagatctt ggcaaaagga ttcgtcgctc 962941 aagtctccgg ggatcagcac tgcttttcgg ccttctgctt caatcagctc ttttacctct 963001 tcagcatctg gctgttcctc gggcaagtag ttaatagcca catcggcacc ttctctggcg 963061 taagcaattg cggcagcgcg gccgataccg gaatcgccgc ccgtgacaag cgcttttcga 963121 cccgttagtt tacctgatcc tttgtagctt ttttctccgc aatcagggac aggcttcatg 963181 ttcttttgca ggcctggcgg ttcttgatat tgttcgggaa attcatcatg aaaaaatgct 963241 tttataggat tcgtaagatt tgaatcagac atcagcaacg ctccttttct gtttggtgta 963301 cattcgtatg tgtacccctg agcataagca gaaaaacatg ttttggcagt ttgaatagtg 963361 aaggaaaaag aaaacaagaa aaaacaaagc cttcttccat atttatcttg tcaaataaga 963421 ctatatgaat tatgataaat tcgagctata aatcaactaa atattgggtg ttgggagagt 963481 gaatcgtcat gaaaaaagcg gcggcggttt tgctgtcact cggtctcgtt ttcggttttt 963541 catacggagc tggccatgtg gcggaagcca aaacaaaggt gaaggtctat aagaactgca 963601 aggagctaaa caaagtatac aaaggcggag tggcccgcac atcgaaggtg aaaaacaaag 963661 gcggaaaaac gaagtacaag ccttacgttt ctaaggcact ttacgatgcc aataaaaaca 963721 aagaccgcga taaagatctt atcgcctgtg aacggtaaat aagaaaaagc aatctggtgt 963781 ccagattgct ttttttatgc ttaggccgcc tgatcggccg cagcgctttt cgccttcctt 963841 gtcataaggc tgactgccat catgaccgtg atattcaaaa gcagggcgac gatgccgaca 963901 ttcaagtctt ttgcggcttg cggcagagcc ggaaataaag tgccgatcgt cgtttccgtc 963961 attgtaatat aagtaactgc tccgacacct gcaataatgc cggcgaaagc tccttgcttt 964021 gtcaccatat tatgcttgag caggctgaac aaaagggcgg ggaatagctg tgtgacaagg 964081 ctgtagccca tcaaaagcag cgtaacgatg gtattcccgc ctttgaaggt aaaatacacc 964141 gaaatcagcg caatcaccgg cactaaaaac ttagcaagcg ccgatacttg ctgttctgtc 964201 gtgcggggcg cgattacctt gtacacattt tttgcaaaca gtgtggaggc ggacattaag 964261 atcatagacc ctggcacaag tgctgtcagc agtccggcag caccgataat tccgacaaac 964321 caagggtcaa atgcttgcag agacagtctc aaaagcgaca aatccccgtc tgcgccattc 964381 agatctggaa cttgcaggat agccgcaaag ccgacgaaaa ggacgaagag caggaccagc 964441 tggtacaaag gcatgatgat ggcgttttta cgaaacactt ttgggttttc ggctgaatac 964501 gaagcggaaa acgtgtgagg ccacatgtaa aaaccaagcg ctgtcaagag tacggttgaa 964561 ctgaaccagg ccacactttg tcccgattcg gggagcgtaa gaaagccagg ctttgccgtt 964621 tcaatctgct gaaacatgtc ttgaaatccg ccgtagtaat gaattggcaa atacacacct 964681 aaaaacagaa cgacaaccag aatcatgatg tccttcacaa ccgatatcca ggcagacccg 964741 tgaatgcctg aaaccataac ataaaccgtg atggaaacag cgccgatcca gatggcagcg 964801 gtcggggtga ttttgccgta cgaggtttcc gatacaatca gcccgaggcc tttcagctgc 964861 agtacaagat agggaatgag tgcggcgatg ccgaccagtg aaacgagaat gccaagcagc 964921 ggactgttgt atttttttgt gaaaaaatca gactgcgaca tcagtttatg ctgtttcgcg 964981 tacgtccaaa ctgctggaag aagccagtaa gaaaggatgt aggccagaca tccgtaggcg 965041 atgatataaa aggctggacc gccttttccg taggcccagc cgctgccgcc gagaaacgta 965101 aaagtagtat aaatttcgcc tgccatcaaa aggaagacga aaacagttcc gaagccgcgc 965161 cctccgaccg tccactgctc caggttcatg tcttttcctt tttgggcgcg tataccgaga 965221 aaaatactca agagcaggac accgaagatg atgatgagag ctgcattcat tctgcttcct 965281 cctttttatt ttccttgtcg aggacataca caatcgccat cagcgcagag gtcaaaagag 965341 cccacatcac aatataggca agaataaacg gcatgccgaa cacatagggg gtcaccttat 965401 ttgcaaaagg gatgccgagt aagattccga taaagggtaa agcggcaaga acgtgaatca 965461 gtttcataga atcctccttc tatttaggat tgaggtgtac aagcctaagc gtactgaaaa 965521 tgatgtcgca gatatcgcag cacatgtcat tttttggagt gaaaggctgt ggttcgaatt 965581 ataaataaat ttattttgtt tgtatagtgt gaattgtctg aaattaatgc tctgaatcgc 965641 ccgaagaggg aacgggcagt atgattcaaa aggctcagag tctgtctggg gcaaatagat 965701 agtatgttaa taattcgctg acctgctcac ggattcgcgg attaaaatag cgatggtttt 965761 cttcataacc gtcgatgaca aatgtataga gtgtaaaggc ctcatcgcgt tccgtctcgc 965821 ggattgcaat ttttcttttc ctcagttctt ttctgacctc catcaaatcc ttttgtgcta 965881 tttttaatga ttcgctgata agctgtttat aaggatgctt caattttaat gtgctttctt 965941 caattccggc gagatcacgg ttaaaaatcg taatggccat gggcaaaaag agagcccgtt 966001 caattaaatc gtatatttcc tcctgcagat ttggcatatt gactccttct ttctaaggga 966061 acgtttgttc tatttgtatt ctatatcggc tggtgaaatg tttcaagaca gaaaaaatca 966121 ccaaaacttt ttagttttct gctgataatg tgtagaataa ggatagacaa acccggtaag 966181 gagtataaat gttggagcat tttttatcct atttgacaca agaacattta actgaattat 966241 ttcaaagcta tagggctttc ggtccgctca ttgctgtgct gctgccttta attgaagcat 966301 ttctcccgtt tttgccgctg atcgtgtttg tggtggcgaa tacgaactcg tttggcttgt 966361 gggaaggatt catcctatcc tgggcgggat caactgctgg ttccattctc gtctttttga 966421 ttgtccgtca atacggacag agaaaattgc ttggatttat ccgcagtcat ccgtctgtca 966481 gaaagctgat gttatgggtg gaaagacacg gcttcggtcc catgtttctt ctgctttgtt 966541 ttccatttac accgtcagcc gcggtgaatg ttgttgccgg tttgtcaagg atcggaacgc 966601 ggccgtttat tttggcggca gcctcgggga agcttgtcat gatttttatg atcagcttca 966661 tcggatatga tctgcacgcg ctgattacac agccgattcg aacggtcatc gccgtattgg 966721 tgatcactgt cttatggtat gtcggcaaaa aggtggagcg gtatctgcat gtaagagcca 966781 gtcagcgtga gcatgatgga gggagacagt aacatgaaaa aacggttttg gtttcttgcc 966841 ggtgtagtgt ccgttgttct cgccattcag gttaaaaatg ctgtctttat tgattacaag 966901 gtagaaggcg tcagtatgaa cccgaccttc caggaaggaa acgaattgtt ggtcaataaa 966961 ttttcgcatc gatttaaaac catccatcgt tttgacatcg tcctttttaa aggccctgat 967021 cataaagtgc tgattaaacg ggtaatcggc ttgcccggtg aaacgatcaa atataaagat 967081 gatcagctgt atgtgaacgg aaagcaggtt gctgagccat ttttgaagca tttgaaatct 967141 gtttctgccg gcagccatgt aacgggtgat ttttctttga aagatgtgac gggaacaagc 967201 aaggtgccga aaggaaaata ttttgtcgtt ggagataatc gcatatacag cttcgacagc 967261 cggcattttg gtccgataag agaaaaaaat attgtcggtg tgatttctga tgccgaataa 967321 aaagacgcta attgaagagg cgtctttttg tatgccgttt ggaaaaatgt gttgaagaaa 967381 aatttgtaag gagctataat caaaattgtt acctgtgtaa caaaatttat atattttttt 967441 gactggaggg ccgtttttat tggtttttgt tcgtttttca tgaaacaaaa ggagtggtga 967501 atgatgatga aatatgaagc agtgattata ggaggagggc cggttggatt tatgctggct 967561 tctgagcttg caatagccgg agtgggaaca tgtgtgattg aacggcttga aaaacctgtt 967621 ccgcattcca aggcgttgac gctgcacccc cgaacgctgg agcttcttga gatgagaggg 967681 attttagagc ggttcgtatc caagggaagc aagataccta ccggacattt ttcaatgctg 967741 gatacccgtc tggatttttc aggcttggat acgagctgtc cttacacgct tttgctcccg 967801 cagtccaaaa cagaaaagct tcttgaagat catgcacgaa gcctgggaac agaggtgttt 967861 cggggtgccg aggcgctggc ggttacgcaa aacggggaag cggtccaaac aatttttaag 967921 gatcgggacg gcagtgtacg gacgatcaca agcaagtttg ccgttggggc agatggcgcc 967981 gggagtaccg tccggaaaca ggcgaaaatt gagtttccgg gaacagacag cactgtcacc 968041 gctgcgcttg gggatgtggt gctcctttct ccgccgccgt caggtgtgct gtccctttgc 968101 acaaaagagg gcggtgttat gattgttccg ttatctccag accgataccg tgtcgttgtg 968161 atcagccctt atcgcacaca aacgccgaaa gatgtgcctg tgactgagga agagctgaaa 968221 gctgacctcc tgcgaatttg cggaactgac ttcggtttaa ccgacccttc gtggatgtcg 968281 cggtttggga acgccgcgcg ccaagcgaaa cggtatcggg acggcagaat ctttcttgcg 968341 ggtgatgccg cgcatattca ttttccggcg ggcgggcaag gactgaatgt cggccttcag 968401 gatgcaatga acctcgggtg gaaactggcg gcggccatca aaggctctgc gccttcttgg 968461 cttttggaca gctaccatga tgagcggcat ccggcagcgg aagggctcct cagaaacacg 968521 gaggcacaga caaagctgat cgatttcact caagcaggcc tccatttgcg aagcatgatg 968581 tcggagctgc tggccttccc tgatgtgaat cgatatgtag cggggcaaat ttctgcgctc 968641 gatgtcagat atgaagctga tcgtaccatg ccgccgaatc gtttgaacgg ggcaaggctc 968701 cctgacatga agctgattct ttccgacggc aattcggaac ggctgtacag ctttctccaa 968761 aacgggacat tcgttttgct gtcattgagg caggaagctg atgatcatat cgaagtaaaa 968821 ggcttacgta cggtaaccgc ctcgcttgca gaaccgaatg aaaagttgcg gaatgtgcat 968881 accatattga ttcgtcccga tggacatgta gcctgggcgg tggatgcatc agcgcccgat 968941 tgttccgagg tgattcaaaa agggatcagc cgctggtttt ccgtcaccag ccgagtataa 969001 ttcaattcga ttgtttcatc tgtaacaaaa cggtatgata gaagaaacaa tcgaatgaaa 969061 aaggatggaa aacccgatga acacagatca tacgaaacgc aatctttttg aattgtatgc 969121 ggagctcatt catcagcagg agaaatggga ggggcttatt aaagcctttt tatctgacga 969181 attgaggaag ctggatgtag agcacgggag taaatctcaa ttgacgatga cagaaattca 969241 tgttctatcc tgtgtcgggg acaatgaacc aattaatgtc acgtcgatag cagaaaaaat 969301 gaatacgaca aaagcgactg tatcacgcat cagcacaaaa ttgctcggcg caggcttcct 969361 tcacagaaca cagctcagcg ataataaaaa ggaggtctac ttccgattga cgcctgctgg 969421 aaaaaagctg cacagtttgc acaaatatta tcatcagaag gctgaacagc gttttctgtc 969481 attttttgac cgctataccg aggaagagat tctttttgcg gaacggctgt ttcgggatct 969541 ggtgacaaaa tggtatccgt cgtcagaaga aattgaaggg gggcttccta gcatttttaa 969601 ataaaaaaca cgcactgcgg tgcgtgtttt tcgctttgcg gccgcctcga gaattctttc 969661 atttcaccct ctggcagcac tcacttcaaa tctgatccat taacaacgaa atatccgctt 969721 atatttcctc atctcgatgg tttgcgaatt aaaagttctt gaaccctttt ttcaactagg 969781 cactactgcc gctgattgag ctctttttgt cttttttttc accatgaaga tggtgaagca 969841 ggcgataaaa cggcggcagc agggcaataa ccagaatgac gcgaatgacc tgaaccgcaa 969901 cgacaaaggt ggaatcagca tgtaaggtaa ctgacgtcgt cgccatctct gcaatcccgc 969961 cgggcgcaaa tgccagaaca gaagtgatga gcgaaattcc tgtcagctcg gaaacgatca 970021 cggcgctcaa aaacattgct gcgattaaac cgacggacga gacaaacccg acgatgataa 970081 tacgggtgac gccggcaaac atgcttttgt acatcttaga gccgatcgtt gccccgagaa 970141 atacttgtga tacatggtta gcttgtgaca accaccatgc cgtcatgtcg tgccctgtca 970201 ccgcagctcc gccaacatgt acaattgcta caccgagcat gctgccgagc agccatggag 970261 ctggaaattt taaaaatttc gcagctttgc aagctcccca ggcagcgaga ataagaatga 970321 cggtccacaa aacgggagcg agcctaaaat ctgtcgttgc agaagaaatc gtctctgctg 970381 cggcacttgc ggtacgatct tgttttgtat agatcagaat gactaaaaac ggaatggaaa 970441 gcaccacgag cagcacacgc atcatttgaa cgaggctgac tatagcggta ttggcgccta 970501 cttcctgtgc gatgctcggc atggcggaaa gtccgccggg agcggtgccg acaaagctag 970561 tcatcatatc cgttttgctg aaacgccaaa gcacatatcc tgacagcatg gccagcagga 970621 tagacaatat cagcataacg ccgactgaaa accaatggtc tttgagaaca gagagaacgg 970681 ataaattcag cttttggccc aattcgatgc cgaggatcat ctgcccgagg gcgagccatc 970741 gtcggttaat tcctttttgg tctggtgcca tcatcagcca tgccggccgt atcatggcga 970801 ggcagcaggc gacaatcagt gttccgatca tccatccaat tgatattccg gttaatgaaa 970861 gaataaaccc cccggctgca ctgattgcga taaaccatag atctttgagg agattttcgt 970921 ctttcttcaa tgtaaaaccc ttcttccttt ttcacgtaac actccaattg ttcacgtagt 970981 gaatgtattt attactatag tatatttttg ttgataaaga aattatgaat tattttctat 971041 aagcgattca cttttcttat gaccttgtgt tcgagctttt ctattgtgta agtcagagat 971101 aaacccgctg tcagcagaca cacggcaaga gcgtaaaaaa tcacttctcc gccaaatgat 971161 gtcaggatca gcccgcctgc cagcggtccg attgagcggg atatatccca atgcagacca 971221 tagacagcat aaaaccggcc cagcaaatga ggcggcgcca atttcgatat gaaggtctgg 971281 atgtgggtta gcccgatgct ttcaccaacc gtcatcaccg ctgccgtcac taaaagcatt 971341 gtcagagagg ttgagcatgc aaagccggct gccgcaaggg agtagcaaat ataagtaatg 971401 aagaggatcg ttttcattga aagcttttcg gtccctttga caagaggtac ttggagaaca 971461 cagctgaata aagcttttgc tgctgaatag atggtcagca tggacagata atcagaaaac 971521 atgtttttgc tgaacagcct gtatgttgtt tctgtttgtg catataacat gctgatgggg 971581 agagaaagca gcaaaagaag caggacaggc ctgtatattg taaagctcgc ggacattttc 971641 ggggtaacag ctgggtgtag cggctttgtc tcaggcagtt tcagtgcagc gatcagaaag 971701 tagataaaca atgctgcagc atctaatgcg aatatccaca cggggttatg attgtacagc 971761 agcatcccca ctagcggtcc tgccgtcaga cccgtcgaat agatcgcatt gatgaccgca 971821 aacacttccg aacgtctgct ttccggcgtg ctttcagcga tttgggcgcg ggaagcggga 971881 atgtacaacg atcttccgat gccattcatg acatagagaa tagcgaaaac atacgcatgc 971941 tcagcaaata caaaccctgt cattgccgct gattgaagaa gcaatgcggt caaaatcgct 972001 gtgcgccgcc caagccgatc cgtcacccgt cctgcagcga gcgtcaggaa aatatcagca 972061 aatggctgaa ggctgatgat cagcattggc atcatgatac tgccgtttaa ttgttcatgc 972121 agatacagca ccataaaagg tcccatcatt gcacctgtca ggcttgtcag caattcgccg 972181 aaaaagcgga gccgaacggg agcggtatat ctcgatttta tagagtgaaa actggtcaac 972241 atgtgatcgc cgcctttcgc tgtttgatat agtagtagtg tatagaaggg gcggcggccc 972301 aaaaagtgaa gaaaagaaga gataaaagtt ccccttttgt cgggaggtgc ggggattgaa 972361 gctgatagag cactacgtgg cgcttgtaaa aacaggctgc gccgagtatg ggcaaatgaa 972421 cgaaatgacg ctcactgaga ttgccgactg tttattttgt acagaaagaa atgcaaagct 972481 cattttacat aagctggaga acagcaattg gattatccgg gaaagcgggg cggggcgcgg 972541 ccgcaaatct aaaatcgcgt ttcttcggag gcctgaggaa ctgcttcttc aaactgcaaa 972601 ggaatatacc atgtcaggaa agcttaaaaa ggcaaaggag ctgcttcagc agtatcagtc 972661 cgcgtttcca gggcttcaaa acgaatataa catgtggcta tcagaggtat tcggatttgt 972721 gacggagaca ggcgagaatg gggcgaagga tgtcctgcgg ctgttcatca cgcctgaatc 972781 tgtcagcagt ttggatccat gccaaatatt tttgcggtct gagggccatt tcgtcaaaca 972841 gatatttgat acactcttca cgtttgattc ggatatgcag gagccgaagc ctcatttggt 972901 tcatggatgg gaagaggtcg gaaaaaaaca atggagattt tttcttcgaa aaggtgtgtt 972961 atttcataat ggacagccgc tgacatcgcg ggacgttgcg tttacatttc agcgcttttt 973021 ggaactggct gacaacccgt ataaatggct tctgcacgga gtgaaacaag tcttagaaaa 973081 gggcccttat tgtgtggagc tcatactcga taagccgaat gcgcttttgc cgtatgctct 973141 ttgtgatgaa cggctgtcca tactgccggc agaacagggc ggcgggaaaa atggaacagg 973201 gccttttcag atgaatcagc aacatagcgg gatgcttgtg cttgaagcca atgagcgcta 973261 cttcaaggga cgcccctatt tggatcgcgt tgagtttgtg ttttctgagc aagccggaga 973321 gatgaacggt tttaccattc aagaaaaaca aacatgtcct gagcagcaaa ctgtctttga 973381 tgagcggcat gttcagtatt tgtcgcttaa tctgaaaaag aaggggcctc ttcagcaccg 973441 aagctttaga aaagcgctcc ggctgctgat ttcctctgaa cggctcgttc gtgaagcggg 973501 agggcaccga agaattccgg ttacgtcctt tttgcatccg agtccttttg agtgggaggg 973561 cgtttcgcca tctgaattgt tgaaaaaaag cggatacgag ggcgaaacaa tcgtgcttta 973621 taccttttcg gaaacggatc atcgtgagga cgccgaatgg attcaaaata tttgcgccca 973681 gcacggtatc aggcttacac ttcaattctg tgatgctgct gatctgcgac ggccggaaat 973741 cgtgcagatg gcggatatca ttcatgacag tgcgacgttt tatcaagaca gcgagtttgg 973801 ttttctgcat ttgctgctgt cggagaacag tttcttgtat cagcatctat ctgaaaagct 973861 gacacagatt tgctcaggaa tgacagagcg gatgttttcc atgcctgacc gctgttcgag 973921 aatcaacatc ctgcgtgaca ttgaccggca gatgatacag gagctgaacg cgatcccgct 973981 gtatcaaaat gtgctccagg tgacatcaag taaaaatgta aaaggcctgg tgcttgatga 974041 agagggatgg attgatttgt actccgtatg gctgtccaaa taaaaagagg gttctttttt 974101 gaaccctctt ttttacgctg ccatgctgcg gcattgttca gcacaggtga agcaggcttt 974161 cgcacatgct tggcaatgat catgatcgtg ctttccgcat tcagtgccgc atgcttcaca 974221 aatatcggcg caaagtgcac aaatttcttt cataaacggg ctgtccgttt gcatggcttt 974281 gaccgccagc gcgcaaatat ccgcgcattc cctgtcaagc cggatgcatc cgctgagatg 974341 atgctgcacg ctttcttcca agcatttagt gaaacaatga ttgcaagcct tcatgcaatc 974401 gatgcaagcc tcaatacaag cctcagaata ttgctccatg gttgattccc cctgtatgac 974461 agtatatggt tttatgtttc acggctgcat ttgaaaaaaa caggggagtg tgtttttagc 974521 taaggggata tgtacatata ccctgaatgg gtatatctaa cgttccatca gatagtatag 974581 gaaccagaca gcgtgatttt gttcatcacg tgctgcgcgc gtaaagacgc ctttcgcttt 974641 taagtttgac gtttcctcgg ccgcacgcaa gtaaaagtcg acggtttctt gttcatcttt 974701 aaaagcggcg tccagtcctc ttgtgaaatt gtccgggcat tcttccgttt gtttcggcat 974761 gatgtgtttg ccggtaattg aaccatacag tgtggaaaat tcacggaggt ggcgaatctc 974821 gtcacgcctg atttcttcaa tctgttttct gacctcatcg ctgtgggcga gttcggcaag 974881 cttgcggtag cattgaatag cactgaattc tccgttgatg gccttctgca aattccgaat 974941 caaaacagga tcttcccggt atggcaccgg atagggatag tagctgtaat gcaaggggat 975001 tcaactccat tcttaggaat tgggcttctg taaaagtata tgttgggcag ggagagatgt 975061 gcggagataa tcagcttttt atatgtgaaa aggccgtttt taccaataga tcagattggt 975121 cattttcgtc aacattcgat aaaatataga gagataaaaa gagaggggtc ttctaatttg 975181 ggagcagagt ttttagtagg caggtccggg agtggaaaaa cgaagctgat catcaacagc 975241 attcaggatg aattgcgccg ggctccattc gggaagccga tcatttttct agtcccggat 975301 caaatgacgt ttttaatgga atacgagctt gctaaaacgc cagatatggg cgggatgata 975361 cgcgctcaag tgttcagttt ttcacgattg gcctggcgcg tcctccagca tacgggagga 975421 atgagcaggc cgtttctgac gagcaccggc gtacaaatgc tcctgcggaa gctcattgag 975481 gagcataaac aggagttcaa agtctatcaa aaagcgagtg acaaaagcgg gtttaccgca 975541 caggttgagc ggatgctgac agagtttaag cgctattgtc tggaaccgga ggatatccgc 975601 cggatggcgg aaagcggaac ggcttccgag tatcgcggag aacgtgtttt atctgaaaag 975661 ctccatgact tatcaattct gtatcagcaa atggaaaaaa gcctcgcaga tcaatatctt 975721 cactctgagg attatttgac attgctggca gagcatatcc cgcttgcgga agatataaaa 975781 ggcgcccata tctatgtgga tggcttttat cagtttaccc cgcaggaatt cagggtgttg 975841 gagcagctta tggttcatgc ggagcatatc acgttttcgc tcacagcgga caagccgtca 975901 tatgagcggg agccgcatga actggaattg ttcagaatga cggggaaaac ctattaccgc 975961 ctgcatcaga aggcgaagga actgaatttg gacattacgt ataaagagct gagcgggact 976021 gagcggcata caaagacgcc ggaattggcg catctagagg cacagtatga agcgcgtccg 976081 gccattccat acgcagaaaa acaagaagcc cttactgtga tgcaggccgc aaacagacga 976141 gctgagctgg aaggcattgc tcgggaaatt cacgccctag tcagagagaa gggatatcgc 976201 tataaggatg tagcaattct tgcgcgccag ccggaagact acaaggatat ggtgaaggaa 976261 gttttcgcag attacgagat tccttatttc attgacggaa aagcatctat gctgaaccat 976321 ccgttaattg aatttatccg gtcgagcctt gatgttctga aagggaattg gcgttatgaa 976381 gcggtgtttc gctgcgtgaa aaccgaactg ctattcccgc tcaatgaacc gaaggccaaa 976441 gtgagagaac aggtcgatca gctcgaaaat tactgtatcg cctatggtat taaaggcgac 976501 cgctggacaa agggcgatcg gttccaatac aggcgttttg tgtcattgga tgatgatttt 976561 gcgcagactg atcaggaaat cgaaatggaa aacatgttga atgacacccg cgattggatt 976621 gttccgccgc tttttcagct tcaaaaacgc atgaaaaaag cgaagacggt tcaagagaag 976681 gcggaggcgc tctatcgtta tttagaagag acggatgtgc cgctgaagct ggatcaggaa 976741 aggcagcgtg ctgaggatga cggcagaatc attgaagcgc agcagcatca gcaggcgtgg 976801 gacgcagtca ttcagctgct tgaggagttt gttgaaatga tgggagatga tgagatttct 976861 cttgatttgt ttcagcaaat gatagaagcc ggcgcggagt cgcttacatt ttctctaatt 976921 ccgcctgcgc ttgaccaggt gtttgtcggc aatatggatt tgtccagaat gtatggcacc 976981 tcctgcacct ttgtgctcgg ggcaaacgac ggcgttctgc cggcacgccc tgatgaaaac 977041 ggggtcctgt cggatgatga ccgggaatgg ctgaaaacga ttggggttga gctatcctca 977101 ggcggacgag agcgtttgct tgatgagcac ttcctcatct acatggcgtt ttcaagtccg 977161 tctgaccggc tttacgtatc gtatccgatt gctgatgcgg aaggaaaaac gcttttgccg 977221 tcgatgatcg ttaagcggct ggaagaactg tttccgcatc ataaggagcg cctgttaaca 977281 aatgaacctg aacaggtcag cgatgaggaa cagctgatgt atgttgtgaa taaaagcgtg 977341 gcacagtcct ttaccgcgag ccagctcagg ttatggactc gggaatacga catcagcgac 977401 gtctggtgga gcacgtacaa tgtgctgatg agtgagcagg acaggctgca atcgaaaaag 977461 ctgttctcaa gcctgttttt ccggaatgaa gtgaagcagc ttgaacgcag cgtgtcgaga 977521 cagctctatg gtgaacgtat tcagggcagt gtatcgagaa tggaaacctt taacgcatgc 977581 ccgttttccc attttgcgtc acacgggctg catttgaagg aacggcaatt cttcaagctt 977641 gaagcaccgg atatcggcca gctgtttcat tccagcttaa agctgatttc ggacaggctg 977701 cgtgagcaaa agctggattg gcgcgattta acgaaggagc agtgcgagct gttttcctat 977761 gatgcggtag agcggctggc accgaaactg caaaaggaaa ttctgctcag ctcaaaccgg 977821 cattattatg tgaaggaaaa actgcaaaaa attgtgacac gtgtgtccgg cattttaagc 977881 gagcatgcga aagcgagcgg attcgtaccg atcgggcttg aactgggctt tggaggaaaa 977941 gggccgcttc cgccgctgac ctttcaactg aaaaacggct gtacgatgga actcgtcggg 978001 cgaattgacc gtgttgataa ggctgaaagc tcaaaaggcc tgctcctcag gattgtcgat 978061 tataaatcaa gcgacaaagg ccttgactta gcggaagtat attacggatt ggcactgcaa 978121 atgctgacgt accttgattt atcgattaca cattcagctg actggctcgg gatgagggcg 978181 acgcctgccg gagtgctgta tttccatatt catgacccga tgattcaatc taatctcccg 978241 cttgggcttg acgagattga acaggagatc tttaagaaat ttaaaatgaa gggcttgctc 978301 ctcggtgatc aggaagtggt tcgcctcatg gatacaaccc ttcaagaggg acgttcaaat 978361 atcataaacg ccggcttgaa aaaagacggc tctctcagat cagactcagc agcagtcggt 978421 gaaaaggaat ttgatctttt gacaaagcat gtgcgccgca ccttccaaga agcgggcgaa 978481 caaatcaccg acgggcgcgt atccattgag ccgtacaaaa tgaagaacaa gacgccgtgc 978541 acatactgtg cgttcaaatc agtatgccaa tttgatgaat cactggaaga aaacgagtat 978601 cgcccattaa aggctgaaaa ggacaagaca atacttgagt ggataaaaaa ggaggcggat 978661 ggcaatgaac attcctaaac cggcagacag cacatggaca gatgaccaat ggaatgccat 978721 tgtttcaacc ggccaggata ttcttgtggc agcggctgcg ggctctggta aaaccgctgt 978781 gctcgttgaa cgaatgattc ggaaaatcac cgcggaggaa aacccaatag atgtagaccg 978841 tcttctcgtt gtgacattta caaacgcctc agcggcagag atgaagcacc gaatcgcaga 978901 agccttggaa aaagagcttg tacagcgccc cggctcgctg catattagac gccagctgtc 978961 tcttttaaac cgggccagca tttcgacgct ccattccttt tgcctgcaag tgctgaagaa 979021 atattactac ttgatcgatc ttgatccggg ctttcggata gctgatcaga cggaaggcga 979081 gctgatcggg gatgaagtgc ttgacgagct gtttgaagac gaatacgcaa agggcgaaaa 979141 ggcgtttttt gagcttgttg accgctatac gacagaccgg catgatctgg atctgcaatt 979201 tctcgttaaa caggtgtacg agtattcccg atcccatccc aacccggagg cgtggctgga 979261 aagctttgtt catttgtatg atgtatcaga aaagagcgcc atcgaggagc tgccgtttta 979321 tcaatatgtc aaagaagata ttgcaatggt gcttaacggg gcgaaggaaa agctcttgcg 979381 cgcgcttgag ctgacgaaag cgccgggcgg cccggcgccg cgtgctgaca attttcttga 979441 tgatcttgct cagattgatg aactgattca gcatcaggac gatttcagtg aactatataa 979501 gcgggtgccc gccgtctctt ttaagcgtgc caaagcagta aaaggggatg agttcgatcc 979561 agcgctcctt gatgaggcga cagatttgag gaacggcgca aaaaaactgc ttgaaaagct 979621 caaaaccgac tacttcacgc gaagtcctga acagcacttg aaaagcctag ccgagatgaa 979681 gcctgtcatt gaaacgctcg tacagcttgt catcagctat ggaaaacgat tcgaagctgc 979741 gaaacaggaa aaatcaatca tcgatttttc ggatttggag cattactgtt tagcgatttt 979801 gacagctgag aatgacaaag gtgaacgtga gccgagcgag gctgcaaggt tttatcagga 979861 acagtttcat gaggtgctcg ttgacgaata tcaggatacc aacctcgtgc aggaatcgat 979921 tctgcagctc gtcacaagcg gtccggagga gactggtaac ctgtttatgg taggagatgt 979981 caaacagtcg atttatcgat tcaggcttgc ggagccgctt cttttcctct ctaaatacaa 980041 acggtttaca gagagcggag aaggcacggg gcggaaaatc gatttaaata aaaatttccg 980101 aagccgggct gatattttag acagcacaaa ctttttattt aaacagctga tgggcggcaa 980161 aatcggtgag gtcgattatg acgagcaggc tgagctgaag cttggtgcag cgtatccgga 980221 caatgacgag acggaaacag agctgctgct gatcgacaac gcagaagata cggatgcaag 980281 cgaggaagca gaagagcttg aaacggtgca gtttgaggca aaagccatcg ctaaggaaat 980341 tcgtaagctg atttcatcgc cgtttaaggt gtatgacgga aaaaagaaaa cacatcgcaa 980401 tattcaatac cgagatatcg tgattttgct ccgttcgatg ccgtgggctc cgcaaatcat 980461 ggaggagctg agagcacagg gcataccggt ttacgccaat ttaacgtcag gctattttga 980521 agcggtcgaa gtcgccgtcg cgctttctgt gctgaaggtg attgataatc cgtatcagga 980581 tataccgctt gcctctgtgc tgcgctcacc gattgtcgga gcagatgaaa acgagctgtc 980641 tttgatccgg cttgaaaata aaaaagcgcc gtactatgag gcgatgaaag actacctggc 980701 tgctggtgac cggagcgatg agctttatca aaagttaaat acgttttacg gacatctgca 980761 aaaatggcgc gcgttttcga aaaaccactc agtatctgag ctgatttggg aagtgtaccg 980821 cgacaccaaa tatatggatt atgtcggcgg catgccgggc ggaaaacagc gccaggccaa 980881 tttgcgtgtt ctttatgaca gggcgcgtca atatgaatca acggcatttc gcggcttgtt 980941 ccgtttcctg cggtttatcg aacgcatgca ggagcggggc gatgatcttg gtacggcgag 981001 agcgctcagc gagcaggagg atgttgtccg cttaatgacg atccacagca gcaaagggct 981061 cgaatttcca gtcgtgtttg tagcaggtct cggccggaat ttcaacatga tggatttgaa 981121 caaatcgtac ctgctggata aggagctcgg atttggcacg aagtatattc atccgcaatt 981181 acgcatcagc tatccgacac ttccgctcat tgcgatgaag aaaaaaatgc gcagggagct 981241 gctgtcagag gaattgcgtg tgctctatgt tgcattaacg agagcgaagg aaaagctgtt 981301 tctgattggc tcatgtaagg atcatcagaa acagcttgca aaatggcagg catccgcgtc 981361 ccaaactgat tggcttctgc cggaatttga ccgctatcag gcgagaacgt atctagattt 981421 cattgggccg gctcttgcca ggcacagaga cttgggggat ttggctggtg tgccagcaca 981481 cgctgacatc tcaggtcacc cggctcgttt tgccgttcaa atgatccatt cctatgattt 981541 gcttgatgat gatctggaag aaagaatgga agaaaaaagc gagcgcctag aagcgatccg 981601 ccgaggtgaa ccagttcccg gctcgtttgc gtttgatgaa aaagcccgcg agcagctgag 981661 ctggacctac ccgcatcaag aagtgacgca aattcggaca aagcaatcag tttctgagat 981721 caagagaaaa agagagtacg aggatgaata cagcggcagg gcccctgtaa aaccggctga 981781 tggaagcatt ctgtacagac gtcccgcttt tatgatgaaa aaaggcctga cagcggcaga 981841 gaaagggact gccatgcata cggttatgca gcatatcccg ctgtcacatg tgccgtcgat 981901 agaagaagct gagcagacgg ttcacaggct ttatgaaaaa gagcttctca ctgaagaaca 981961 aaaagacgct attgatatag aagaaatcgt gcaatttttc catacagaaa tcggcggaca 982021 gctgatcggt gctaagtgga aggaccggga aataccattc agcttagcgc ttccggccaa 982081 ggagatctat cctgatgcac acgaggcaga tgagccgctt ttagtgcagg gtattattga 982141 ctgtctctat gaaactgagg acggattata tctattggat tataagtcgg accggattga 982201 gggcaaattc cagcatggat ttgaaggagc ggccccgatc ttgaagaaac gatatgaaac 982261 gcaaattcag ctgtacacga aggcagtgga gcaaattgca aaaacaaagg taaagggatg 982321 tgcgctttat ttctttgacg gagggcacat tctgacatta tagcgagatc cataagctcc 982381 ggaatttcag gcggagcggg tctcgttttc tatataaaag agaggtgaaa gcatttgcgg 982441 attttacata cggctgactg gcatcttgga aaaacgcttg aaggaagaag caggctgagt 982501 gaacaggccg atgtgctgga tgaactgaat acgattgtaa aggatgagca gatcgatgcc 982561 attgtaatgg cgggggatgc atttgacacc gtaaacccgc cagctttagc cgagcagctg 982621 ttttatgaaa gcctgtctgc gcttagcgac agaggaaagc gcccgatcgt cgtcattgcc 982681 ggaaatcacg ataatcctga ccgtttgtcc gccgcttcac cgctgacaca tgaaaacggc 982741 attcatttaa tcggttatcc gacaacagag ccgattcata ttgaagtgcc ttcagcagga 982801 gagcttttgg cggttggagc gctggcgtac ccatctgaag cgcggttaaa tgaagtgcta 982861 tccgatacgt ttgatgaaaa gctgctccgt gatcactatg atgtgaaaat caggcaggcg 982921 tttgagcata tgacaagccg gttccggacc gatgcagtga agattgccgc cagccatatt 982981 tatgtggcag gcggaaacca aaccgattca gagcggccga ttgaagtcgg cggtgcatac 983041 acggtggctg ctgaaagcct gccggcagat gccgcttacg ttgcgctcgg ccatttgcat 983101 cgcccgcaaa cgatcaagcg ggcgcggacg cttgcgcgtt attcaggatc tccgctcgcc 983161 tacagctttt ctgaagcggg ctacgctaaa tcagtgacga ttgtggacgc aaagcctggg 983221 gaagaggcca cttggcaaga ggtgttatta tcaagcggca agccacttgt gaagtggaaa 983281 gcggcaaatg gattaagtga ggtgtacagc tggctggatg aaggcagaga tcagaatgct 983341 tggattgact tggaaatccg tgtcgcggac cagctgtcac ttgaagagat tcacaggctg 983401 cggaaggcgc acccgggctt tatccatatc aggccggttt ttgaagaaca gaacaaagac 983461 cgggaacgga tcgaggttaa acatgtctca atcgaggacc gctttaagaa attttatgaa 983521 aaacaaactg gcggtgcggt gccggatgaa gaaatggtga agctgttttt agagcttgca 983581 tcaggcgttg aagaggagga tgcgaaatga agccgatcgc cttaagcatt aaggggctcc 983641 acagctttag agaggagcag acgatagatt ttgaaggcct ttccggtgcc ggtgttttcg 983701 gcattttcgg cccgacagga agcggtaaat cctctatact cgacgcaatg acgcttgctt 983761 tatacggaaa ggtggaacgg gcggcgaata atacgcacgg aatcttaaat cacgccgaag 983821 atacgctgtc tgtgtccttt acctttgcgc ttcagacgaa tcaccaaatc tcatacaaag 983881 tcgagcgtgt gtttaagaga acggatgaaa tgaaggtaaa aacggcactt tgccgcttca 983941 tcgaaatcaa ggacgagcat acggtgctgg ctgataaagc cagcgaagtg aataaaagag 984001 tggaggagct cttagggctg acgatcgacg attttacgag agcggtggtg ctgccccaag 984061 ggaaatttgc tgaatttctg tctttaaaag gggcagagcg caggcatatg cttcagcgtt 984121 tatttaattt ggagcaatat ggagacaggc ttgtgaaaaa gctgagacgg caggcgcagg 984181 aagccaatgc gagaaaaaat gaaatgcttg ctgaacagtc cggtctcggt gaggcgagct 984241 cagaggcagt ggagcaggct gaaaaggttc tcgaacaagc tgaagcccgg ctggaagcga 984301 tgaggaagaa ccgtgatcag gcgaaggagc ggtttacaga gcatcaggag atatggaatg 984361 tccaaaagga aaaatccact tatgaagaag aggaaaaacg tctcgcagaa gaacagccgc 984421 atatagacag catgcaaaaa cgcctgctgg aagcagaaac agcagcagcc cttaagccct 984481 atgcggaccg gtacgcagaa gcgatccagc atgaggagca agctgaaaag gaacaaacgc 984541 tagcccaaaa ggatttagca gaccggacag ctttctttca gcaaaaacat gaagagtatg 984601 aagcgtggcg ccagcataaa agcgagaaag agcctgagct tttagccaaa caggaacagc 984661 tttcacgctt gcaggaaatc gaaatcaaac tgagtgaggc caagcaagag gaagagcgca 984721 aaaaggctga cctccggcag aaagaagagg ctcttcaatc tgtcatgaat gaattagaga 984781 ccgtaacaga ccgcctgaca cgagggcaaa acagacagac agaattgaag cagcagctca 984841 aatccctgca ggtgacatcc gatgagcgaa aaagctgcca gcaggccgca gagatggcat 984901 tgcgcatcag acaaaccgag gaacaaatca aaaaagagaa aaaacgaagt gaagaattga 984961 acctcgtgct gcagaagatg aatgaagaga agaatacact cgttcaaaag acggaagcgg 985021 aagaaaacaa catcattcag gcatatgagg cagttcaaac tgtgtaccat ttggtgtgcg 985081 aaacggaacg ctcattaaca cgtatgacgg aagaggctag aaagagtcaa cacacgcttc 985141 acttacagcg tgaaaaagca agggtggcac tgctgacaaa agagttagcc caaaagctga 985201 ctgccggaaa gccttgcccg gtatgcggtt caaccgatca tgatccatct gcctcggtac 985261 atgaaacgta tgaagccgac agccatcttg aagaggacat caaacggaca gatgtgttat 985321 tgacggaagc tgcagctctc agccaggaga ttctttcagc caaaattatg cttgaagaac 985381 agtccgcgcg ctttattgaa cagtgtccgt ttttgcagac aattcaagca cagaaccttg 985441 aagcggcagc ttccttcgaa catcagccgg tgtatgaagc atttgaaact gccaaatttg 985501 aatggaaacg aatcaagcag gacattcttt ctgttaagac acgaatggca caaatgattg 985561 gcgcctatca ggagtcttta aaaaaggccg agcagcttaa tgaaaaaatc ggttttgaaa 985621 aaagagaagc cgaccgtatt gaaagcatca tcagtgagct tcaatcctca atggacagca 985681 gtctgaacat gtttaaagaa gcatttcaga atcaatctgt ggacgaagca gaaaaatggc 985741 agcaagccat tgaagaaaag gaccgggctg cagaagaatg tgaaaaacga attgagaaga 985801 gtatcgcgtt tcttgctgag catgaagcac aaaaggaaaa actgcgggaa tcgggacacc 985861 ggcttgagcg ggaaaagctg gagcttcatt atgcggctga acgcatcaag agcgtgatag 985921 ctgattatga gcacgaactc ggagattatg caaaaggaga ttcgattcaa atcaaactcc 985981 gctctgtcca gcaggatcta aagctgttaa aggaaaaaga acaatcttta tatgaagaac 986041 tgcaaagcgc ccaaatgaag ctcaaccaag cgaaaagccg cgcttctgca agcgagctca 986101 ctcttcaaga ggcgaagggc agattggaaa aagcaaaagc tgcttggctt gagcatacaa 986161 aaaacacctc cattacccgg actgaggagg ttgaacaaag tctcatccca gctgatgaac 986221 ttgaaaagat gaaaaccggc atagaccagt ttatggataa actgaagcaa aatgctgcaa 986281 acttaaaacg agtagcagag atacttgccg gcagagcatt atcagagagc gaatggaacg 986341 aaaccgttgc agcattacaa gaagctgagg acgcatttgg cgctgctata gaggaaaaag 986401 gcgcggccgc aaaagcactg gctgtcattc gcgaccatca taaacggttt aatgaaattg 986461 aagctgaact gaaaaaatgg cagatgcata tcgacaggct ggacaagctg caagctgtgt 986521 ttaaaggcaa taccttcgtc gaatttttag ctgaggagca gcttgaaagc gttgcgaggg 986581 acgcctcagc aagactcagt atgctgacaa gacagcgcta tgccatcgaa gtagattctg 986641 agggcggctt cgtgatgcgg gatgacgcga atggaggcgt acgacgcccg gtttccagtt 986701 tgtctggagg agagaccttc ctcacctcgc tttcacttgc tcttgcgctg tctgcgcaga 986761 ttcagcttcg gggggaatac ccgctgcagt tctttttctt agatgaaggc ttcggcacac 986821 tggatcaaga tctgcttgat acggttgtaa cggccttgga aaaacttcag tcagacaacc 986881 tggctgtcgg tgtcatcagc catgtgcagg aactgcgtgc acggcttccg aaaaagctga 986941 tcgtccatcc ggctgaaccg agcggccgcg gtacgcgggt atcacttgag ttgatgtaag 987001 ggaggagcgg atatggcaaa gcagattgcc ggaatatgtg agctgtgcgg ccggagcgat 987061 gtccagctga cagagcatca tcttacaccg aaagaggaag gcggaacgtt tttgccgaca 987121 gcgatgctct gtattccttg tcataaacag attcatgcct tatataccaa tcaagagctc 987181 gctgtacgtt taaatggaat ggctgaactc agaagcgatc cagagcttgc ccggtttgtc 987241 aaatggatca gaaaacagcc gcctgagaag ctgatcaaaa ctaagaaatc aaatgaacga 987301 aaaaagaaaa aatgactaaa aagcagccct ctctttgcag agcggctgct tttatccgtt 987361 tccaaccata tccggaagca aaagttgttg ttgaaaagta accaaaaagc ggtgctcgat 987421 gcaccgcttt tttatttgcg cccccgttgg actgctgtgt acataatgga tcgctttccg 987481 tttgaagccg tccattcaaa acggtctcct gtcccttcgc tgctgtagtt gtagtgatgc 987541 tgcatcgcgc attgtgcggt gtcatttgaa aagtgataaa aggacacacc ctgccccgcc 987601 gaagtattcg aaaagactcc tttattataa gaaaagacgc aatcgaatac cgataagccg 987661 aagctgtgca agtgctgcag aaatgcgaga aaggtttcgt cgtcaagcga atccaaaagc 987721 gccatgagcg gccgcttgac tgatttctca tagcggatgc gttctccgcc ggaaagggag 987781 atgttttctg caccgcatgc caaaaccaac ttgtcctgaa agccggcttg ctcccacttt 987841 cctttatgat ggatccagat tgggctgtgt tggagactgt ccgccagcag tatatcgcct 987901 tcaccgtttt cgattaagca gatgccgtct tcaatgagga tggtgccgta ttcccacttt 987961 cgttcctctg tatataacaa ttgtttccgt ttcatccatg ctgtctcctt tttcttcatt 988021 cctctctttt ctttccaatt caagcctgtc ccatacaact cttttatgga caaatcaact 988081 atctgcctat agatgcataa acttactaag gtgctgaaag aaacgaaatt gttacgaaag 988141 aaacgggatt ggagctgatg tcacatgtgt ggaattacgg gttgggtcga ttttaaaaag 988201 cagctcgtcc aggaaaaaca aacgatggac agaatgacag acactctttc caaacgaggg 988261 cctgatgatt caaacgtttg gggggagcac catgttttat tcggacataa aagacttgcg 988321 gttgttgata ttgaaggcgg acgccagccg atggcgtgta cctataaagg cgatacgtac 988381 accattattt acaatggcga gctttataac acggaagatt tgcgcaaaga attgcgggcg 988441 cggggccatc aattcgagcg tacgtcagat accgaggtgc ttctgcacag ctacatcgag 988501 tggcaggaag actgtgtcga ccatctcaat ggcatattcg ctttcgctgt gtgggatgaa 988561 aagcgtaatc tgttgtttgc cgcgagagac cgtctcggtg taaagccgtt tttttacacg 988621 aaggaaggct cttcatttct cttcgggtcg gaaatcaaag caatcctcgc gcaccctgat 988681 ataaaagcgc gagtggacag aacgggactt tctgaaattt tcggtcttgg accgtccaga 988741 accccgggca ctggcatatt taaaggcata aaagaaatcc gcccggctca cgcgctgaca 988801 ttttccaaag acggacttaa tatttggcgt tattggaatg ttgaaagcga aaaacatacg 988861 gacagttttg atgacacggt tgccaatgtc agatcgttat ttcaggacgc ggtgacgcgg 988921 cagcttgtgt cggatgtgcc tgtttgcaca ttcctatcag gcggtctgga ctcaagcgcg 988981 attacagcga ttgcggcggg ccattttgaa aaggaaggaa aagcaccgct tcatacttat 989041 tcgattgatt acgaagagaa cgataaatat tttcaagcaa gcgcttttca gccgaatgat 989101 gacggaccat ggattgaaaa aatgacagag gctttcggca caacgcacca caaatgcgtc 989161 atcagccaaa aagacctcgt tgatcatttg gaggaagctg tactggtcaa agacttgccg 989221 ggaatggcag atgtcgactc atccctgctg tggttttgcc gggaaatcaa aaaggacttt 989281 gtcgtcagcc tatcgggaga atgcgcggat gagattttcg gcgggtaccc gtggttccat 989341 acggcagatg ttgagtctgg ctttccatgg atgagatcaa cggaggagcg gatcaagctg 989401 ctttctgact catggcagaa aaaattgaat ctgaaagaat acgtaaatgc caaatatgaa 989461 gaaaccttgg cagaaacgcc attattagac ggagaaacgg gtgtggataa agcaagaaga 989521 cagctgttct atttaaatat gctttggttt atgacgaacc ttttggatcg gaaggatcgc 989581 atgagcatgg gggcgagcct ggaagtgcgg gtgccgttcg ccgatcaccg gcttgtggaa 989641 tatgtttgga atattccgtg ggaaatgaaa atgcatgata atcgggaaaa aggcattttg 989701 cgcaaagcgc ttgagggcat tttgcctgat gacattttgt atcgcaaaaa aagcccatat 989761 ccgaaaacac atcatccgga atatacaaaa ggcgtcagcg agtggctgaa aacgatcaga 989821 agccaaaagg actccgtgct ccatacctta ctggacagaa aacaattaga tcagctttta 989881 gaaacggaag gctcctcctt caaggtcccg tggttcgggc agctcatgaa ggggcctcag 989941 ctgatcgccc atcttgctca aattcataca tggtttgaag cgtatcgcat tgatattgac 990001 gagaggtagg ttcaatacaa atgtgattaa aagccagaga tgtatagatt taaataagaa 990061 ggatagatga gcagggaaat atatgctcta tctatccttt tttgtacaac agcactatcg 990121 aattgccccc gcattccttc aataagaatg aataggtttt aatgttctgc cgataaaact 990181 agctgatacc gggcttaact ttaattccct agcccataca gaaagttgac caatatggtg 990241 aatttcgtga gcgatgatat ggtgtaatat ttcatctcgc gtatataaaa cacctgtctc 990301 ccaaggaacg cttacaagtt catcttttat ttgatctgaa tgtgtttgta aaacatcaat 990361 tatttcagtt cggaatgtat ttgagagaga tttcacttta ttgagtgttt gataatcagc 990421 gaactgaaca gcgatatctt cttttccttg gatagcacga atccaactat attccacatc 990481 aataatatga aaaagggtat ataaaatatt ctctactccg ccaagacgat ttttaagtaa 990541 ttcttcagtg gttagttgat gacaccaagt aaaccattga tctctaacct gccagttata 990601 ttcaaaaaat ttcatcacta aactcactcc aatactatca tgtatcataa caattagccc 990661 ttttttccgt gattcctcta ttaatgaagt gatgattgag aaatgtttac attctacctg 990721 ttgtatggca ttaaaaataa taatgcatat ctcgtcgatg atgctgtgcg tcttgttact 990781 tttacaaagt aagaatcggc attttcttca tatacaatta ggaaaaaaca tactagactt 990841 gaagaagcag tgatacatag gagtgagaaa atgaaagaga taaaagaagc ttaccagcaa 990901 tgcggacaga ttgttggcga atacgcgcca gcctgtttca aagcattatc atatctcccg 990961 ctaaagcaaa gacaagcctc ttgggcagta ttgtcgtttt gccacacggc ggccagtgca 991021 gacgaaaagg tattgcccgc atttgaagct aaagctgatc atgtttacca aaggacaaat 991081 aacggtaaac aacatctatg gaaggctttt gatcatgcgt atcggacctt tacattggaa 991141 agcgaacctt ttcgggagtt tattgccgca caaaaagaag acgccaagcc gtatgatgac 991201 cttgatgaac tgctcatgta cgcatatcgg acgggcggtg ctgccggatt gatgctgctg 991261 ccgatactga cacgccgaaa acaagatcag ctcaaacaag cagccgtctc tctcggcttg 991321 gccatacagc tggttcgctt cttaagtgat cttggcacag atcagcaaaa aaaccgcatt 991381 ccccgtcagg taatgcagca attcggctat acagaggctg atctccaaaa aggcaccgta 991441 aataaagcgt tcacaatgac gtgggagtat atcgcttttg aagcagaagc ctaccttgaa 991501 gagtgtcagg atgccttgcc gctatttccg cagtattctc aaaaaacggt gaaagccgct 991561 cttcatttgc accgggctgt tttagaaaaa atccgggcga agcagcacga tgtatttcaa 991621 tatcacttcg ctctcacaga gaccgaagtg aagcagattc tgtctgatat ctaaaaaaca 991681 cccggccttg attgagccgg gtgttacgcc ataccttttt gaatccagat acgtgagcgc 991741 catcttctgt acattaagat tccccggacc cattcatccg cgataaaaga aatccaaatg 991801 ccggcaagac cgaaaccgag gtggatgccg aaaagataag caagcgggag gccaatgccc 991861 cacattgaaa tcattgccat gtaaaccggg aatttcgcat cccccgcggc ccgcagagag 991921 ttaatgataa tgacattaaa cgagcggcct ggttcaagga taatggtcat ggcaatcaat 991981 aggcttgcag ttgctataat gtcagggctt tgtgtgaaga gtccgatcag gtcttttgaa 992041 aagatcgtca tcaaaacaga ggtagccgca gcaattccga gtgcccaata taagctcttc 992101 atgcagcgct cataagcggc atcaaattgt ttgccgccga tataacggcc gattaagatt 992161 tgtgtaccct ggctgatcgc agtgccgaac agcaaaataa acatcgtaat attttgcgta 992221 tacacttttg ttgtcaacgc ctgcgcgccc atgatggcga taaaatacgt gactatcatt 992281 tgcgacaggt tgtatgaaag ctgctctccc gcagaaggaa tgccgatttt cagcagcttg 992341 cgcaaatgct ctttatgcat atgaaagact tttttcagcg acatcttcag ctggatgcgt 992401 ttgttgacaa tcacaatcat cgcgattaat ccgatgacgc gggcgataga tgtggacatg 992461 gccacaccgg caacaccgag aacaggaaag ccgaacaaac cgaaaatcac aacaaagttt 992521 ccggcaatgt ttaaaatgtt catgccgata gtgacaaaca ttgtatcttt tgtgtagccg 992581 tagcttttta agatcgcgct gaatgtcatg attaaagcct gaataaagga cagacctccg 992641 acaacttgta aaaagacttt cgcatcaggc atcagtgcgt ctgataatcc catcatatga 992701 agcagaggga cagccgcgaa aaagacgacg gcgctgatgg ccaggctgat gaagaagttg 992761 gcgccgattg acacataagc gacttccatg gcttctttct tttgccgtga gcctagaaat 992821 tgtgaaatga taacggtcgt tcctgttgcg ataaagctga acatcacgat aattaaattt 992881 aaaatctggt tgctgacgcc gactgctgcc acgctgttat ccgagtattg gctgagcatc 992941 agtgtatcgg cattacccat aaacatatat aatgagacct caataaagat cggccaagta 993001 agcgaaaata atgagaacgt tttgtcagcg ggttttttca aagcagttga tttgaagaca 993061 gcttgtttca tcgtgtctaa cccctttcgt aaataaaatc aacgttttaa agtgtacctc 993121 catttcctta taataaaaag ggatagaaac gatacttctt gtaaaaatcc gacttaaaaa 993181 ggaggatgat tcaaatgcct cgcatcctgt ttacagtccc gccttttccg gtatttatcg 993241 cagctgggga aggggttttt aaaaaaggag aaacccatgt gaaacgtgta ttctccgtgt 993301 ttgatctgat atatgtcaaa cagggaacgt tatatataac ggaaaatgaa acatcgtttt 993361 ctgttgaagg cggcgagtac atcttgcttt ctcccggtct tgaacactac gggacgaagg 993421 gcagtgatga agcaacctcc tactattggc ttcacttcga tgaacatcga tatgaattta 993481 cggcaaaggg aggcagcaac tggtctgagc ttcagcagga aaaagggagc ttcgaagagc 993541 tggcccgcta cggattggcc ttgccgagaa aaggcaaggt gcagcgcccg cagtttatgg 993601 cgcagcagtt tgaaaagctg atcgattact ccgcggaaaa ctctgatttg ccgctcagaa 993661 agcaaatttt atttgaggag ctgatgctgc atcttcaaaa agaagcgttc caaataccgt 993721 ctgcgaaaga gcgggtagcc tgggaggcgg cccggtattt acaggagcac tataaggaaa 993781 agacgacaat caaggatctg tcgctcgccc ttcactatca tcaggattat gtgagccgct 993841 gcatgcagca ggtgctcggc gtaactccgg cacaatacac gaaccgggtg agaatgacgg 993901 aagcgaagcg tcttttatcc tctacaaatg ataaaatggg cgttattgcg gaaacggtcg 993961 gaatggaaga tccgacatac ttttcaaaac tctttaagca gatagaaggc atttcaccaa 994021 ttgaataccg gaaaattgtc agccggaaag ttcaataacc agacgaggga tgaacatgaa 994081 aacaacaatt tacgatgtgg caaaggcggc gggtgtttcg atcacaactg tgtcccgtgt 994141 gataaacaat acggggagaa tcagcgataa aacacggcag aaggtcatga atgtcatgaa 994201 tgaaatggca tacacgccca atgtccacgc cgcggcgtta acgggaaaac gaacgaatat 994261 gatcgctctc gtggcgcctg atatttcaaa tccgttttac ggcgaactgg ccaaaagcat 994321 tgaggaaaga gcggatgagc tcggttttca aatgttgatt tgcagcaccg attacgatcc 994381 gaaaaaagaa acaaagtatt tttctgtgct gaaacagaaa aaggtggatg gcattatttt 994441 tgcaacaggg attgaaagcc atgacagtat gtctgctttg gaggaaatcg ccagtgaaca 994501 aattccgatt gccatgattt ctcaggataa gccgcttctt ccgatggata ttgttgtgat 994561 agacgacgtt cgtggcggat atgaggctgc caagcatctt ctgtcactcg gccacacgaa 994621 catcgcctgc attatcggag acgggtcaac gacaggcgaa aaaaatagaa tcaaaggctt 994681 ccgtcaggcg atggaggaag cgggcgtgcc cattgatgaa tcacttatca tccagacgcg 994741 gttttccttg gaaagcggca aggaagaagc gggaaaattg ctcgacagaa atgctccgac 994801 tgctattttt gccttcaacg acgtattggc ttgtgccgcc atacaagctg cgagaataag 994861 aggcataaaa gtgccggatg atctttctat cattggtttt gataatacga tactcgcaga 994921 aatggcggct ccgcccctga caaccgtagc ccagccgata aaagagatgg ggcggagcgt 994981 catcgaactg ctggcagaag caatagaggg aaaacgaaag gcgaaacaaa aaatagtgct 995041 cccgcctgag cttgtagtca gacattctac atcaccgctc aacacatgag cccgctaatg 995101 agcgggtttt ttcattatga cagttgaagc caaaaaaaca tattgcgtgt aaaccaaagg 995161 cggtgtaaaa tataaccatc ttttgagaaa gcgcttgcgc aaaatggcag agcggataga 995221 accgctgttt ttttagctgt taagagaaaa cgctttctca aagcgagccc gaaatgagat 995281 aaaggagagg atgggacgtg gaacatcaag taagatgtgc agtattggga ttaggaaggc 995341 tcggttatta tcatgcgaaa aatctcgtca ccagtgtgcc gggggcaaag ctggtttgtg 995401 tcggtgatcc gttaaaaggg agagcggagc aggttgccag agaactcggt atcgaaaaat 995461 ggtcagagga cccgtatgaa gtgttagaag atcccggcat tgatgctgtc attatcgtaa 995521 cgccgacaag cacacatggt gatatgatca tcaaagcagc cgagaacggc aaacagatct 995581 ttgttgaaaa accgctgaca ttaagccttg aggaatcaaa agcagcttct gaaaaagtta 995641 aggagacagg tgtcatctgc caagtcggct ttatgagacg gttcgatccc gcatacgcag 995701 atgccaaacg gcggatcgac gctggagaaa tcggcaaacc tatctattat aaaggcttta 995761 cgcgcgacca aggcgcgcct cccgcagaat ttatcaaaca cagcggtgga atttttatcg 995821 actgttccat ccatgactat gatattgccc gttatttgct aggggcggaa atcacttctg 995881 tttcaggaca cggcaggatt ctgaacaatc cgtttatgga gcagtatggc gatgtggatc 995941 aggcgctgac gtatattgaa tttgactcgg gcgcagcggg ggacgtcgag gcaagcagaa 996001 cctctccata cggacatgac atccgggcgg aggtgatcgg gacagagggc agtattttca 996061 tagggacatt gagacatcaa catgtgacca tcctatcggc taaagggagc agttttgata 996121 tcattccaga ctttcaaact cgttttcatg aagcctactg cttggagctt cagcatttcg 996181 ccgagtgtgt ccggaatgga aaaacaccga ttgtgactga tattgatgcg acgatcaatt 996241 tagaagtggg tatcgccgca accaattcct ttcgaaacgg catgccggta cagctagatg 996301 tgaagcgcgc ttatacaggt atgtaaaagc taagtatgtt gcatttgagg ctttccgcaa 996361 aaaaagcaag ggcattttag cccttgcttt ctcttttctc atataaatag tacatataat 996421 cagtaggtac gcctgaatgg tccagctgtc tcagcatggc ggttacgttc cctctgtggt 996481 aagtgccgtg attgacgaca tgcaggatgg tgtctgcata ggttgattcc agtgtaccta 996541 gtttcggatg ctgcattgtg aaggtctgtt ctaagtccgt ctggcggctg aagaaatcat 996601 gatactgtga ctccagctcg gcagcgtgct gtttaatcgc tgccatatta ccttgcgcgg 996661 actgtaattt gcctgcgctg tctataatct cttggtaggc cactcccgaa agaacattca 996721 gccaaatgta gtcagccctg cacatatgaa gcagcacgtc gctgacagaa ggaaatacgc 996781 tctttacttc ttgataggca gtttcctccg gcaggttttc gatatgggta aatattttct 996841 tgtttgccca agaatgatag tcataaaact gttttgcatc agtcatcagc atgccccctt 996901 ttctaagaaa ttcgtttttt tcatctgttt ctccttcaat tgcaaaagag tgacacccca 996961 aaatatcctg ccgctgccca cattaccgct gcagagcatt tgtttacgat cagcataagc 997021 ctgccgctcg tatctatcgt ctgaaacaac cggcccgcta ttgcaaggct gatgaaccaa 997081 atccaagaca cagcgatgca ggcggccata aagagccatt tctcaagccc cgaatattga 997141 agagagctcg tgccgatgac gccgatcgtg tccagaatgg catgcgggtt taaaagagaa 997201 acagcggccg caaacgcagc ttgctttttt ggtgtgaacg tatgtttctc attttggctt 997261 gtgttcggac ggatgttcca agtcacccag cccatataaa gcaaaaataa aaatccgccg 997321 gccatcatga ctgtctcaaa cacaggcagc tcctgcacaa tgacagacac gcccgcaacg 997381 gctaatacaa ttaacaaggt atcgcagact gaagcactga tgacagctgg gagagcccgc 997441 caaatatgct tttgcaacgc gccttgctga aaaataaaca cattctgcac tcccagcggc 997501 aaaattaagc caaacgcgag cacaattccg tgaatgattg cattcatgct gaaaaagctc 997561 ctttcacatt ttttttcaat cataagagag attgtcacta aagtctccag ccatttggtt 997621 gggttaggaa ccagccaaat gtataatgtg taaaaaaggg gggcatgacc ttgtcgcaat 997681 ggcagccaag ccgaaagtcg gatgttccgc tgcatcggca gatcgaacaa tatatgaaag 997741 acaagattct tcacggagag tgggctgtag ggacgaaaat cccctcacag agaacgctgg 997801 ccgacatgtt tcaagtcaac cgcagcacag tcacagcagc catagatgaa ctcacgtctc 997861 aaggcttgtt agagggaaga aaaggcggcg gtacgaaggt tgtaaacagt acttggagcg 997921 tgctgacggc tgagcctccg cttgattgga gcgattacgt ccgttcgggc attcatcgcg 997981 ccaattcttc catcattcaa gctattaatc agaacgaacc aagagcggat atcatcagat 998041 taggaactgg agaactttca ccggatcttg tgcctgctga cacaattgga cggatgtttc 998101 agcaaatcaa tccgggcgtc ctgtctttag gatatgagca gccgaaagga aaccgtcagc 998161 tgcgggaggc agtggccgac catttaaaag gaaagaagat ccatgtgtca ccgtctgcaa 998221 ttttaattgt gtccggtgca cttcaggcac ttcagctcat ctcaattgga cttttaaaac 998281 gagattctgt cattttgacg gagaagccgt cctaccttca atccttgcat gtatttcaat 998341 cagctgggat gcggcttcgc ggcttgccga tggatgatga aggggtcaaa gcggggcttg 998401 tttcttctaa tcgaaaacaa tatggaggac agctgcttta cacgattccg tcgtttcata 998461 atccgacagg cacagtcatg tcagagcagc gaaggaaaga gatcatcagc ctgtcaaaaa 998521 aagagcagat gcccatcatt gaggatgatg cgtacggtga tttatggttt gaagaaaaac 998581 cgccgcagcc gttgaaagca atggatcatg agggcaatat tctgtatctg ggcgcgtttt 998641 caaaaacggt tagccccggt ctgcgaatcg gctggcttgc cggtccggag ccggttattg 998701 aaaggctggc ggacattaaa atgcagacag actacggatc aagcggcctg tcccagtggg 998761 cggctgccga gtggctgtca cagggatatt atgaagagca tctgacttgg gtacgcagga 998821 agcttaaaga aaggagagac gccgccgttc attttctcga gcggtatgcc ggggacattg 998881 ccacgtggcg gattcccgca ggcggctttt atatttgggt gacatttcac aaaaacctgc 998941 ctgtcagccg tttcttttat gaattgctga aacggcaggt gcttgtgaat cccggctata 999001 tttatgacgg tgaagaccga aacagcatca ggctgtcata ttcctatgca tctcttggag 999061 atttggaaac tggcattaaa gcggcagctg aaacagcacg ccgcctgatg atgtcctagg 999121 ctttggttat acgatgacag ctcccagtgc cctggcgaag gcaatcgcgt gctcaggtgc 999181 gattttgcag cctttcaatt tgtcgaggga gacatgaagc tgttcaaaac ggcacgtgct 999241 gatgtccatg ttttgaaggg acgtgccggt aaagctggcg ccttccaatt cgcatccgtc 999301 aaagtgtgtc tgctggagca ccgtatcgct gcattcactt tgcataagag cacagtgatc 999361 aaatcgaact tgtttcatat ttgagtacga aaatgagctg aaatgtccgt ggcattcctc 999421 gaatgaaaca ttccgcagcg ttgcttccgc cacattcatt ccaaccattt ttgactgctt 999481 aactgaagtt ctgtgaatga cagccccgct gaaatcggcg tttgataaat cgcatttttc 999541 aaagatcaca tcggtcagtt caatatgccg aaaagacaca tcgataaaga cgacatttct 999601 gaataccgtt ttttcaacac atagtctttc gatatcttcg ccgcagatgg tgcaatcttc 999661 aaacaaatgc atgctgatta catcatcctg tgtcacggca tcatgaaaat ctgcggtttg 999721 caggttttcc ggtatgttcg gtttttgaat tgcgatttta ttcatgtgat gacatccttt 999781 gctgcccgaa aaacagaggc ttccgggttc aatttaatag atcgttaagg aaattgatac 999841 atatagtaaa tcgtgaagag ccttttcttg gtacagcagc ccgcttgttt tgtaagcata 999901 aatggaaagc ttcctatacg tcaaggcgtt tacaggccga aaaagccaaa gggaacagga 999961 ggaatgcgga atggggcatt acatcaaaac cgaggagcat gtgacactgt ttgtagagga 1000021 tatcggacat ggaaggccga tcatcttttt gcacgggtgg ccgttgaatc ataagatgtt 1000081 tgaatatcaa atgaatgagc ttccgaaaag gggatttcgt tttatcggcg ttgatttgcg 1000141 gggatatggg caatctgacc gcccttggga aggctacgat tatgacacga tggccgatga 1000201 tgtgaaagca gtcatttata cgctgcagct tgagaatgcg attcttgccg gtttttcaat 1000261 gggcggcgca attgcaatcc gttatatggc aaggcatgaa ggagccgatg ttgataagct 1000321 gattttactg tctgcggcgg cccccgcgtt tacaaaacgc ccgggttatc cgtacgggat 1000381 gaggaagcag gatattgacg atatgattga attgttcaaa gctgatcggc ccaaaacact 1000441 ggctgattta gggaaacagt tttttgagaa aaaagtgtct ccagagctta ggcagtggtt 1000501 tctcaatctg atgctggagg cttcctccta cgggacgatc cactcgggca tcgcattaag 1000561 agacgaagat ctcagaaagg aacttgctgc aatcaaggtg ccgacgctga tcctgcacgg 1000621 gagaaaggat agaattgcgc cgtttgattt tgcgaaagaa ttgaagcgcg gcatcaaaca 1000681 gtcggaattg gttccgtttg caaacagcgg gcacggagca ttttatgagg aaaaagagaa 1000741 gatcaacagt ttgattgcgc agttctccaa ctcataagaa aaaacccgac attgatcggg 1000801 ttttttatat aattcctctg ttttgcagtg cgttaatgat gagatcagct ccatcggaaa 1000861 tagaggtctg gtcagactca atgatgaaat cgggtgaaag cggcgcttca tacggagaat 1000921 cgatcccggt gaaatgtttg atctctccgt ttcgcgcttt tttataaagc ccttttggat 1000981 cgcgctgttc acaaacatgc agcgggcact tcacataaat ttcgaagaac tcacctttag 1001041 gaaagagcgc tctaaccatg tcccgatcct ctctgaatgg agaaataaaa gccgttaaaa 1001101 tcatttgccc gctgtcgaca aacagcttcg ccacttctcc gatccggcgg atgttttcaa 1001161 tcctgtcacc agtctgaaat ccaagatctt tgtttaagcc gtggcggata ttatcaccgt 1001221 caagcacgta gctctgaatg cccttgcggt aaagcttttc atcgacagca ttggccagca 1001281 ccgattttcc ggagccggac aaacctgtaa accaaaggac gcagcttttg tgtccgttta 1001341 aggactgtct gtcagacttt gagatggcag cgggatgcca aatgatgttc ggattgtgtg 1001401 tcattgcaat tccccgctgt tttgcttgat ggcaacaggc tgttggtgaa gtcccttgat 1001461 cagcacggct gcgacctcag gccggctgaa ttctttaggc ggctttttgc cttggcggag 1001521 aagctctctc acttttgtgc ctgataagtg gatgtggtct ctcgggctgt gcggacatgt 1001581 tttggaggtg cccatgtttc cgcattttcg gcaataaaag ctgtgctcaa aaaacagcgg 1001641 cttgatgccc agctcttcct ctgtgaatga ttgaaaaata ttttgggcgt cgtatgttcc 1001701 atagtagctg ccgacacccg cgtgatcacg gcctacaata aaatgggtac agccgtaatt 1001761 ttttcggacg agcgcatgga aaatcgcttc ccgcggacct gcataacgca tggcggcagg 1001821 gaaaaccgat aacatgacac gatcctttgg ataatagtga ttaagcaaag cctggtagct 1001881 ctccattctg atatcgctgg ggatatcgtc tgactttgtt tctccgacaa gtgggtgaag 1001941 cagcagaccg tcgaccgttt ctaacgctgt tttttgaatg tattcatgcg ctctgtgaac 1002001 agggttcctg gtttgaaagc cgacaatcgt cttccagccg agtttttgaa aggccgctct 1002061 tgtttcagcg ggcgttgcat aaaactgttc gaaagatttg tcaggcaggc tgctgaccgt 1002121 gataggccct ccgatatagt aatccgggcg cgccagcaat ttttttacgc ctgggtgggc 1002181 aggatcgttt gttttaaaaa cagacagtgc ttcttgtgtt ttatcaggct ggtatatatc 1002241 ggtgactgtg atcatgccgt aggtaacacc gtctttcaca agcttgacgt gatctccggc 1002301 agacagctgt cttgctgttt tttctccgac aggcagcgta atcggcaggc tccacggcaa 1002361 gccgtttgcc agcctcatct ctttcacaac ggaatgataa tctttttctc ccaaaaaacc 1002421 tgttaacggg ctgtagccgc cgatcgcaat aagctccaga tcactcagtg caagctgatc 1002481 cagctctgct tggcacgcgc acccttcaaa atggcatgcg ggatcacagc ggttgattaa 1002541 tacccctccg tggggttcgt ttccattcaa cgtgttcaac ctccatttat acgtttcctt 1002601 gttttctttt ctgcacttaa tgaaagtttg acatcagcgc cttaacatca tttcgattct 1002661 cacatcaaga acctgccatc cgctattctt gatgcaggcc gcattctgtt ttctcccgtc 1002721 cggcccatct tccagccctc tcatcgttcg ggtccgggga aggcagtgta cacatttcac 1002781 agcctatgct cggataatgt tgatcgtgca gtttgttata aggcaaattg tgcaggcgga 1002841 tgtacgtcca aacgtcatcc catgtccagt ggataagcgg gcaaattttg atgagctcaa 1002901 acttctggtc caggtttacg tattgaatat gctttctcgt tggtgactga tcccggcgca 1002961 gtcctgaaat ccaagctgtc atgccggaca ggtgcttttt gagcggttcg attttccgca 1003021 attggcagca gaggttcggg ttatgcttcc acagctctcc gccgtacttc gtcccctgtt 1003081 ctgttaagct cagctcgggt tcgagcatct ggattgcaaa tcccggatat cgttctttga 1003141 cggtctcgat cagctcatat gtttcctgaa aatgaagccc ggtatccaaa aagatgatgt 1003201 gtgcgttttt gttgattttt gatattaagt cgagaagcac cattccttct gcgccaaagc 1003261 tgcaggcgta cacaatcttt tctccgtacg ttcggtaagc ccatttcaac acatcgagct 1003321 catcgatcaa ttgatccgtt atctgtttgg acagcatgtc gttccaagtg tcatatgtga 1003381 tggtttcgtt caatgttttc cccccgtttg catctgcttt ttttatctat tgatcgagtt 1003441 ataggcagac tattcatttt ttgcataaag gttcaggttt taggtgccgc gcccgcctaa 1003501 aatgaggtgc ggaaccatta agagcccggc tgaatatgct ttttagcaaa atggttttat 1003561 gcccaaggag aggtagtatg ccgattgcca tttatcaggg gcatcatcat tcgcttgccc 1003621 cggcggacat taacatcgtc attgatgtca tcagagcctt tacggtcgcc cattatgcgt 1003681 ttatcggcgg ggcgaaagag attttgttgg tccggacagc tgatgaagcc tttgcgctga 1003741 aagacaccta tccggattat gttttgacgg gagaggaaaa gggggtcggt atcagcggat 1003801 ttgatttaga taattctcca aaacgtatgg ctgggcagaa tatgacggat aaaagcctga 1003861 tccagaaaac aacaaacggc gtcacagcag cattgggggc gctgaacgca aagcatctgt 1003921 tcgtaactgg attttccaat gccaaaacaa cggcacagca tgtgaaaaag ctcgtcgcaa 1003981 acgattgtgt cataaacata gtggcttccc atccatccgg tgatgacgat atggcatgtg 1004041 cggagtatat caaaggcatc attgaaggga caaatgtggt aacggctgcg gaggcgattg 1004101 aaagaataaa aggctcttct gttgcggaga agttttttga ctgccgccag ccattgtttg 1004161 attcggaaga catcgtttac tgtacaaaag aactgacggg cgatttcgtg atgaaagtga 1004221 aacaagatgg agaagttcca acgatagaga gggtcataat atgaatgatt tttcactaga 1004281 attgccagtg agaacaaaca agccgagaga aaccgggcag tccattttaa ttgataacgg 1004341 ctatcccttg caatttttca aagatgcgat agccggagcg tccgactata ttgattttgt 1004401 gaaattcggc tggggcacat cattacttac gaaagatctt gaagaaaaaa tcagcacact 1004461 gaaagaacat gacattacat ttttctttgg cggcacactg tttgaaaagt acgtaagcca 1004521 gaaaaaagtg aatgaatttc atcggtactg cacctatttc ggctgtgaat atattgagat 1004581 ttcaaacggt acgctcccga tgacaaataa agagaaagcg gcttacattg ccgatttttc 1004641 tgatgaattt cttgtgctca gtgaggtggg cagcaaggat gcggaattag caagccggca 1004701 aagctctgag gaatggcttg aatatatcgt tgaggatatg gaagcgggcg cggaaaaagt 1004761 gattacagaa gccagagaaa gcggaacggg agggatctgt tccagcagcg gcgatgtcag 1004821 gtttcaaatt gttgacgaca tcatttcctc ggatattgat atcaacaggc tgatttttga 1004881 agcgcctaac aaaacgcttc agcaagggtt tattcaaaaa atcgggccga atgtgaatct 1004941 tgccaatatt ccatttcatg atgccatcgc gttggaaacg ctgcgtttag ggctaagatc 1005001 cgataccttt tttctgtaaa atagcggctg cggggctctc gtcgtgaaga gagcctctgc 1005061 ctattatttt ttatggcggt acataggcgt gagataggga agtgaggtca ggcggatgtt 1005121 gtagatgaag tcgatgactc ttgtcgatat cacctggcat atgagggctt gaatgacgat 1005181 gccccagtca ataatagacg cggtgaccat aaaaatgatg caattcatga tgagcaggat 1005241 cgttccagga ttcccgccgc ggtagataga aatcatcaga gcaagggctc cgaatcctcc 1005301 gttcgaaatt ttatatttgt ataaaagtcc gattccgagt cccaataaca ctgcgccgct 1005361 tgccagatca agccacaggt tagatgtgat atcaggaaaa actgcatcaa agatcaatac 1005421 cgagacagag gtgacggtga tagaagcgag ggtgccggtg aatgttctca tctccagcca 1005481 ttttaaagcg gtaaaaagca ttgatacatt cacagcccac actgaaaatc cgtgggggat 1005541 ttgaaacaga taatgcaata gcaccgcaat acctgctgca ccgcctgtcg gaatatcatg 1005601 cggaaataaa aacaaggaca tgccgagtcc ttgtagtacg ccgcctacga caatcataaa 1005661 cgtaagtttt gctttcatca gcagttcagc cattaagtca tttgctcctt tatgaaaaga 1005721 cttgtccgct gttttcattt tatgaggctg tccattattt atgtctcaaa ataaagaaat 1005781 ggcccagctt aataggctga gccatcccac ttgtagcgat tgacgatctc catattgatc 1005841 tctgtgccaa tgccttttcc tttcgggatg tggaccattc cttttgaagg ctgcaggctg 1005901 acgagatctg taaaaggatt ctccatgacg tcccactcga tcggttcaat gtgatcgttc 1005961 ttcattttag accatggggg cagacaggct tgtgcaaata aagcatagag ccgtgagagc 1006021 gatccgtcat atgcatgggc ggatgctctg acgccgaaat aacgcgcgag ctggaggcag 1006081 tcccgaaact catcaattcc gttgacatgc atgacatcgg gctgaatgat atccaaacag 1006141 cgctgtgaaa ggagaggcac atattgcgcc gggcctttca tgttttctcc gccggcaaca 1006201 ggaacagaca aacggcttcg aagcatagcg taatcctgcg gctgatcaaa gggcaaaggc 1006261 tcctcaagcc agccaatgtt cgtccattcg gagaaatagc gctcccattt aaaagccgca 1006321 gcggcatcgt agctttggtt tgcgtccaga atcatcgtaa tggagctgcc tgctgtatgc 1006381 tgcagcgcat tgatgtgccg gacatcctcc ttgaatgaag tcccgccaat tttgactttg 1006441 atttgctcaa aacctttttt caactgggct tcaacattgg agactgagcg gctgatccat 1006501 tgcggggagt ctgagtacga ttgaaaagac gcgtacacag gaatctcctc tctgtatcgc 1006561 ccgccccata attcgcaaac cgaacaatcc gcagctttgg ctgcaatctc tgtcagcgcc 1006621 atgcttacag cggaggccgc ccgctggtgc catttttgaa tcgtgcgcac taatgacagg 1006681 cggctgccag cctgttttcc taatagaaat gggatgatcc gcttcgtaaa accgacatgg 1006741 agagcaggga gccaatcaac gcattctccc cagccgtcta tcccgctttc ggtgataatc 1006801 ctgatgagat aacaagtccg atatcgttta aacccattgg catctccgta tggcttttct 1006861 aatcgatgaa atagcggaaa ggtttcaatc cgtacaattt tcacactggg tgctaccttt 1006921 cctcagcggg ctggagccga ttgccagcca ttttagggtc ttctttttct tttgtttctt 1006981 cattgttttg cttcacatgg atgagcatca tcacaagaat cccgacaacg agagtcaatc 1007041 ccgcgatgct taaaaacatg ccgggtctgg accattgcat caggcggccg aaaatcggag 1007101 gaccgatcgc tacccctaag aaacgtacag agccgtacag cgaggtgaca aatccccgtc 1007161 tttctttgcc gacagccccg gtaatgaaac tgttcacaca aggaaggaca agacctgagc 1007221 ctatactgct cagtacaaga acactgataa aaaggacaag attttcaatg aatgacagtg 1007281 ccgcgtagga tacggtcatg aacgccaatc caagtacgat cagctttttc attaacgatt 1007341 gcttttgccc gattttgctt cctgttgtat aggacgtcac acacataacc aaaagcggga 1007401 tcgctaaaat taagcctttt ttcacgccgt cggtgtcgta tgttttttca agaacatctg 1007461 agagataaaa caggatgccg aataaagtaa acaaacaggt cgcaccggct aaataagcgg 1007521 taaacagcca tctgccttca tgtttaaaga cacttaacag cccttttgca tattgtccga 1007581 ttggtggcgg ttctttttcc tttttctttt ctttaataaa aatccaagtc agtacgatcg 1007641 aaatgataca aaacacagga aaggcaaaaa acgcgccata ccagacaagc agggcgatca 1007701 gcgagccaat gatcggcgat agcactttcc ccatgccgtt tgaagcttca acaaggccga 1007761 gcaccttgct ctcctgggcg cctttaaaca gatctcccgt cagtgccatg gcaattgggc 1007821 cggttccggc tgccccgatt ccctgtaacg ctcgtcctgc catgacccaa ggataggcat 1007881 tgtcaaaaaa acctgccgca aacccggcta acaaaccgcc ggcaccatac aaaattaagc 1007941 agggaataat gatgactttc cttgagaatc ggtctgcgag ataaccgaca atcggaatcg 1008001 caaatgctgc aatcaaggaa aatactgtga tcacgagact gacttgaaat tgtgataaat 1008061 gaagttcaga tttcattttt ggcaaaatcg gaataagcat cgagtttcct agggttaata 1008121 ttaaagggat tgaaccgatt gccacaatcg tcattccgtt attttgtttt gatgattcca 1008181 tctcagagca cactcctttt cttctgctta gaatgtccct gatggcttcg tttattcagc 1008241 gatcagacag caaaaaaccg aacagaagat acctgttcgg gaaaaaagag ggttaaccga 1008301 gagcctgtga aatcaaagca tataagtgtc cattttgaat aggcgctttt ttctgataga 1008361 acaaaatcgg aggttcatca tctttatgaa atcccatttc tatcaggctg tcatgcagag 1008421 acgtgtgttc actcggtata tcgattcgca tcggcccttg tttgccggcc gccagccttg 1008481 taattatctg tgctgcaaca tctgatgatg gagcgatgat agggccgaat ttcaaattgg 1008541 ccggtgtctg tacagaaagt ccgtagccaa tgagctgtcc gtcctgattt ctggcgatga 1008601 tacattcgca tgaagcagaa ataagctgct gcaaaaggtt tgatcgatct ccgccaaagg 1008661 cagccagatc cgccgcggtt aagtcgtgaa agtcttgttc tctaaaggat gtcagttcag 1008721 catcaagctt ttttgtataa ggttgaaaac tgtgacagct gtactttcgc actgaacctg 1008781 ccgtatgaaa acctgctttt tcataaagcg gcaaaccttc ttttgtggcg caaagcctga 1008841 tggcggtgtt ttcatccgtt tgggtaatac aggcgtttac catacgccgg ccaagaccga 1008901 gccgttgata ttccttgtca acgataacaa ggccgataga agtaagacgg ccaaacaaaa 1008961 acaagccgat gcaggaaata atatcaccgc tgacattttg ataaccgaaa aagcgtccct 1009021 gctgaacaag cagtttcagc tcttgttcgc cataatccgg ccacccggct tgcccgcaaa 1009081 gccgcaataa gccggaaacg tgttcttcat gaagcttaat cagttcatct actacgtcca 1009141 taagatcacc tgcttgttct aagtgttttg tacatgacaa tatgattgcc aatgccggga 1009201 atgtcaaatg gttcgccaag ttccttccag ccaagcttgg catagtagcc cttgacatgg 1009261 tgtcttgcgt tgcaccatac cgcctgaacg ccgctctccg ccagtttgtg ctccgcgtgt 1009321 ttgatcagcg tgcttccagc tttttgatcg cgatatccct cgagcgttgc catgcctctc 1009381 agccgatacg cagaggcttc cgttaataaa ggctgacttt gcggggaaaa agaagcgatg 1009441 ctgatcagcg ttccatcata aaacacgccg agatgaaagg agccttctgc gtgatcctct 1009501 ttatatttgc attgttcgat ggattgatgg ggacgcagaa tgcgatgccg gatttcatat 1009561 gtatcttcca cggaaatggt tttgacttcg agcataatgt tcctcctcat gattgttttt 1009621 ctatatcgta acacgaatct cgttgaaaaa gactgcccga ttcgatcagg cagtcttttg 1009681 gaaattaatg caaaaagata ttttggcgct gctcatcttt ttgctgaata tatgatgtga 1009741 gctcagcggt taagtcagat ctgaggaaag gcgttatcaa gtagatgccg ttaaacagct 1009801 cgcatgccgt atccagcagg gagcgtgcaa ttgcaaggcc ttccgccttt tgcttttctt 1009861 tatcttcacc ggcatgggcc attttttcgc gaatcgtatc agacagctta atgccgggaa 1009921 tttcattatg gatgaattcg gcattccggc tgcttgtcag cggcatgatg ccgatataga 1009981 tcggcgtctt cagatgtttt gtttcgttat ggatatcgac aagctgctgc tcggaataga 1010041 caggctgaga aacaaaataa tctgcgccgc aatctatttt tttctcaagc cgttttaccg 1010101 ctttatccag atggcggacg ttaggattaa atgcggcggc aactgagaaa ttcgttttct 1010161 tgccgagcgg ttttccagac agagacagac cttcattgaa ttgtttgatc agcctgatta 1010221 aatcaaaaga tgttaaatca tatacagacg tcgccccagg aaaatccccg attttagaag 1010281 ggtcacctgt aatagcaagc acgtcattca gccctaacgt atcaaggccc attaaatgtg 1010341 actgtaagcc gataatgtta cggtcacggc acgtaatatg gacaagggaa cgcatatcga 1010401 gctgctgctt gacaagggcg ccgcaggcaa cattgctgat ccgcggggtc gccaaagaat 1010461 tgtcggcgag tgtcagggca tcgattcccg cttcttttaa ttcagcagca gcggacagaa 1010521 atttgtcaaa gcttagtttt ttcggcgggt ccagctctac gataatagag cgttttttcg 1010581 ctgcgatctc atccaggccg ggctcggttc gctcgtgatg aacagaaatg aattctttcg 1010641 cccgggtttt gacttctttt tccgtaatcg gagccagccc gccaaccgct tccgccatcg 1010701 ccctgatgtg attcggcgtt gtgccgcagc agccgccgat aatccgcgca ccttgcttac 1010761 ggaattctga cgcgctgttt tgaaaatacg tgtcgtctgt ttcatagacg agccgtccct 1010821 cttcaagcga aggaagactg ctgttcggat aaacggataa gaatacgtca tcaaaaatcg 1010881 gcacttcgct tagcgcttca atcatgtgat aagggccgag gcggcagtta atgccgacaa 1010941 tatcagctcc gagatccgca atcgagcgca atgcgtcaga aagcggcgtt ccgtcctgca 1011001 atacgccttg ctcgtgcatg gagacattga gcataatcgg aagatcagtc tctttgcgcg 1011061 cgattttcag cacttcacgg gcttcttcca aatcataata tgtttctaac agcaagccat 1011121 ccggctcttc atgcagcagc agatacagct gctcgcggaa gctgcgctta atttcgtcaa 1011181 gactgtatgc gtttttatta aatgtgcgta tgccgcccat cgttccaagc acgtatgcat 1011241 cgcctgctga agcccgcgcg atctttacgg cctcctgatt catttttttg atgtcatcct 1011301 caagcccgtg tctggataat ttaatatagt tggctccgta cgtattcgtt tgaataatgt 1011361 tggctcccgc ttcaacgtac gctttatgta tgcgctgaat ttcctccggc tttgaaatat 1011421 tgagctcctc aaaacacctg tcaatgccat aggagtagag gagcgtcccc atggcgccgt 1011481 caccgattaa cacctgtctt tgcaaatctt ctaaaagtcc cattgtctgc ctcctttatt 1011541 cacatcagca aggaaaaaag agaaataaaa aaagtcctct taagaagaag actttgtcag 1011601 tgattttgtc tcttcttatc ttccaagctg ttcgagcttg ctggatttag caccttggtc 1011661 atggctgatc gccattacac cggttgctga agcttcgtcg ggccagtccc tctgcttctc 1011721 ttgataagaa cggatatgaa attttcgtgt caggaagtgc caaaagatat ctggcgtttt 1011781 tccctttctc caaatttacc gaaaataaag acaataatca ataggaatca gaaaatttat 1011841 ctgaaattta taaattgaac gtcaattggc agatctgctc cccgtacagc tgagataatc 1011901 tgctgcaggt catctttgtt ttttccggtg acacgcactt gatcatcctg cacctgagac 1011961 tttactttca gtccggagtt tttgatgatc gtattgattt tttttgcgtt gtccttgtca 1012021 atgccttgaa caagctttgc acgctggcgc accgttccgc ctgacgcgtt ttcaaccttg 1012081 ccgtaatcaa tgttttttgt cggtacgttt cgtttaatca atttgctgac cagcacatct 1012141 ttcagctggc ttaatttgaa ttcgtcatcg gaaacgagga ccagctcctc tttatctaaa 1012201 gaaatgtcgc ttttgctgcc tttaaagtca tatcgggtac tgatttcctt cagtgcgatt 1012261 tggattgcgt tttgcacttc aggcaattcc accttggata caatatcaaa tgaactttct 1012321 tttgccatat gaaaacctcc ataacattta acttatgtgt tgattatagt agaataaaga 1012381 gaaacttcca acagaacaaa gaatcaattt gtgatgattg gaaaaaatgt taacaaaatc 1012441 cgcagagaat aagcggaaca ggaaggacga tagcatgaga ccagggcagc aattaacctt 1012501 gagtatagat caccaaaccg acttcggtta ctttttaacc gatggggaag atacgattct 1012561 cttacataac agtgaaatga ctgaggatat cgaggacaga gacgaagtag aagtctttat 1012621 atacgtagac cagcaggaaa ggcttgcggc cacgatgaaa attccgatca tcagcgcgga 1012681 tgaatatggc tgggttgaag tggtggataa agtggaagat atgggcgttt tcgttgatgt 1012741 cggtttatcg aaggacgcac tagtcgcaac tgagcatttg ccgccgtacg aagatgtctg 1012801 gccgcaaaaa ggggacaaac tttactgtat gctgaaggtg acgaaccggg ggcgcatgtt 1012861 tgcgaaacca gcgccggaag atatcatcag cgaactgttt accgacgctt cagaagatct 1012921 gatgaataaa gagctgacag gtacggtgta caggctgatc gcatcgggtt cattcgtgat 1012981 cacggatgac ggtatccgct gttttattca cccgtcagaa agaaaagagg agccaagact 1013041 gggttcaaga gtcacaggcc gggtgattca agtgaaagaa gacggttcag tcaacttgtc 1013101 gctgcttccg agaaaacagg atgcaatgtc agttgatgct gagtgcattc taacgtatat 1013161 gagaatgaga aacggtgcca tgccgtacag tgacaaaagc cagcctgacg atatcagaga 1013221 acgttttaat atgagcaaag ccgcctttaa acgcgcgctg ggccatttga tgaaaaacgg 1013281 aaaagtgtat caggaaaatg gatggacata cgagaaaaaa tagcatgaaa acggctcgcc 1013341 tgcagcagac tgcggagcga gccgtttttt tatgtctagt ttaattcatc aaccagcggc 1013401 caactatatc atattaattt gccaaaatcg tgttcaaata tttgttttaa gggaaaacat 1013461 aataaagaag aaagagcgga ggaacatgcc atggtactag atcaaacaaa aaaattactc 1013521 atcgtcatca tcggcgcttt actcaatgct gccgggctga acttattttt gatacctgca 1013581 gatgtatatg ccagcggatt tacaggtgtt gcccagcttt tatcaagcgt cgttgatcaa 1013641 tatgccccct tttacatatc gacgggaacg ctcttgttcc tcttaaacat tccggtcggt 1013701 attttaggat ggctgaaggt cggcaaatcg tttacagtgt acagcatttt aagtgtcgca 1013761 ctcactactc tgtttatggg gatcctgccg gaaacaagcc tgtcacatga cattttgctg 1013821 aacgcggtgt tcggcggcgt catttccgca gtcggtatcg gcttaacatt aaaatacgga 1013881 gcttcgacag gcgggcttga tatcgtcgcc atggtacttg caaagtggaa ggataaaccc 1013941 gtcggcacgt atttcttcat tctgaacggg attatcatct tgacggcagg attattgcaa 1014001 ggttgggaga aagcattata taccctggtt acactatatg tgacaacgag ggtgatcgac 1014061 gccattcaca ctcgccacat gaagcttacg gcaatgattg tgacgaaaaa agcggacgaa 1014121 atcaaggaag ccatttacgg aaaaatggtg cgcggcatca caactgttcc ggcaaaagga 1014181 gcatttacga acgaacagaa agaaatgatg attatcgtca tcacgaggta tgaactgtac 1014241 gatttagaaa agatcgtcaa agaagttgat ccaaaagcat ttacgaacat cgttcaaacg 1014301 acagggattt ttggtttctt tagaaaagac tgacgaaagc aggtggaagt cgtgaaacgg 1014361 ctgcttgtga tgctcctccc cgtgctgctt ttgataggct gcgggaaaga tgagcagaca 1014421 gaacccgata aggaggtatc aggcggaatg gagaatcaag aggttgtttt atctattgac 1014481 gcaattcagg agcctgaaca aatcaagttt aacatgtcgc tgaagaacca aagcgaacgt 1014541 gctattgagt ttcaattcag cacagggcaa aaatttgaac ttgtcgtgta tgattctgag 1014601 cacaaagaaa gataccgtta ttcgaaagaa aaaatgttta cgcaggcttt tcaaaacctg 1014661 acgcttgaat ctggagaaac atatgatttc tctgatgtgt ggaaggaagt ccctgagccc 1014721 ggaacctatg aggtaaaggt gacatttaag ggcagggcgg aaaatctcaa gcaggttcag 1014781 gctgttcagc agtttgaagt caaataagag gctatggcga gtcgccatag ccttttttta 1014841 ttgcagtttg tccagctgat tttgaaattg atgcaactgt tgacgttccg catctgtcga 1014901 attggcatac gcagaagata cagcattttt ggctctcaga atcgcttgct cctgatcgcc 1014961 ttcctcaaag ccgtttgtca ccatgaccgc ctgttgaaca aatgattttg cctgctgaaa 1015021 cagttcattt ctcatttaat attcatactg cctttcagcc gagtctcgtg ccgcggcatg 1015081 ctggtgagct tcttctaaag tagaccgata tggaaatctt gcggcgtgta gcccgatgga 1015141 gtctttaccc tgctgaataa accttctgga tttgcttcgt ttacccattt tgagactgcc 1015201 cccttccata ctttgacgag atgagtcgtc ttcaatagta tggtggggta aagtaaggtt 1015261 tatgagtggg aaaaattaat acggaccttc tttaaagtga gaaatattct ttcaaaaacc 1015321 ttgccacgcc gtcctcttca tttgtggccg tagttcggtt ggcaatctgc ttgaccgcgt 1015381 caattccatt tcccattgca acgccgcagc ctgcaaattc aagcatttcc aaatcgttat 1015441 cctcatctcc aaaagcaatg atccgctccc tcggcacgcc gtaataatcg ctgattttct 1015501 gcaggccgac cgctttattc atgccgcttt tgataatttc aatgacatgc caaggagcgg 1015561 cccatcttct atggtcgatc acctcggcat gcacatccga taaatatgag cgtattgccg 1015621 gcacatcctc ttcctttgca tgtatgagta cggacgtcac atcttcaccg agattttccc 1015681 gcaagtctcc gaccgttaca tttgttgtgt tcatgttaaa ggcatctatc aggtgctcat 1015741 catggtaatg aaagtatacg tcgtcaatca cttcagcaag cacgttatgt acgttgtagc 1015801 tctcgctgat atccacgagc tgtttgacaa catcaagcgg cagtgacgta tgataccgtc 1015861 cccagctgtc gtcttgcgga tgatggacaa atgctccgtt aaaattgaca attggcgttg 1015921 tcagctccat ctgctggtag tacatggaac ttgaacgata cggacggcct gttgagatgc 1015981 agacataatg cccgtcatct tttaggcgct gtatcgtatg aagggtgttt tcagatatgg 1016041 ttttatcatc ctttaataat gttccatcta aatctaatgc gattaaatag ggttttgtct 1016101 ccatgaaaag ctcctttaac cttagatttt gcttgttttg ccttacttac agtgtagctt 1016161 tttaccatct ttattgtcta catgttacac ttatgattat ggttatccta aggaggggca 1016221 cattgtgata caaattgaga atcaaaccgt ttccggtatt ccgtttttac atattgtaaa 1016281 ggaagagaac aggcaccgcg ctgttcctct cgtgatcttt atacatggtt ttacaagcgc 1016341 gaaggaacac aaccttcata ttgcttatct gcttgcggag aagggtttta gagccgttct 1016401 gccggaggct ttgcaccatg gggaacgggg agaagaaatg gctgttgaag agctggcggg 1016461 gcatttttgg gatatcgtcc tcaacgagat tgaagagatc ggcgtactta aaaaccattt 1016521 tgaaaaagag ggcctgatag acggcggccg catcggtctc gcaggcacgt caatgggcgg 1016581 catcacaacg cttggcgctt tgactgcata tgattggata aaagccggcg tcagcctgat 1016641 gggaagcccg aattacgtgg agctgtttca gcagcagatt gaccatattc aatctcaggg 1016701 cattgaaatc gatgtgccgg aagagaaggt acagcagctg atgaaacgtc tcgagttgcg 1016761 ggatctcagc cttcagccgg agaaactgca acagcgcccg cttttatttt ggcacggcgc 1016821 aaaagataaa gttgtgcctt acgcgccgac ccggaaattt tatgacacga ttaaatccca 1016881 ttacagcgag cagccggaac gcctgcaatt tatcggagat gaaaacgctg accataaagt 1016941 cccgcgggca gctgtgttaa aaacgattga atggtttgaa acgtacttat aaagcactaa 1017001 gttattaaca agagctgaat ttacgttata ctgtagaaaa aaggagtgag ggaacgtgga 1017061 agaagcatta aaagaaaaca tcatgggcgc cctggaacag gttgtcgatc ctgagcttgg 1017121 cgttgatatc gtgaacctcg gcttggtata tgacgttgat atggatgaag atggcttgac 1017181 gcacatcacc atgacgctaa catcaatggg atgcccttta gcgccgatta tcgtggatga 1017241 ggtgaaaaaa gcattagcgg accttcctga agtgaaagac acagaggttc acattgtatg 1017301 gaatccgcct tggactaggg ataaaatgtc cagatacgca aaaattgcgc ttggcattca 1017361 ataaaacaaa aaaggacagc ctgacatgtg aggctgtcct tttttacagc tgaaaggagt 1017421 gaaaggaaat gatgtacctg ctggcagttt tatgcccgcc gcttgctgtt ttgttttcgg 1017481 gaaaaccgtt tcaggccttg ctgaatctca tattgacctg tatcttttgg ctgccgggcg 1017541 cgattcacgc ctgctttatc gtcgccgacc gccgtgccga aaaacgggca agaagataat 1017601 ttggaaaaat gaggacgcag tcatggtata atggtcataa aaacagcagg gagagcacta 1017661 tgaaaaagaa attgcttgca ttcgcgcttt gtactggcgc gtatgcggcc ctgtttgcgt 1017721 actctgtgaa ctcagagcaa aaaacagcca caagcgagat gacggatgtc agccgcctga 1017781 tgcctgtaaa aataaagcag acagtgaaag ggcaggaaga ggaaatgctc attgacacag 1017841 tcaaagaggc aaatcgaaaa aacataaaaa tttcaatcgc cggggcccag cactccatgg 1017901 gcggccatac atattatgag gacggcatcg ttctcgacat gacgggctac aacaaaatcc 1017961 tgtcactcga tcaagagaag aaaaccatca gggtgcaaag cggtgcaacg tggaatgata 1018021 tccagaaata cgtgaatcca tacggactcg cggtaaaagt catgcagtca caaaacattt 1018081 ttacaatcgg cggatctctc agcgcaaatg cacacggacg tgatattcgc tacggctcgc 1018141 taattgatac agtcaaatca ttccggcttt taaaagctga cgggatgatt atcactgtca 1018201 ctccaaaaga tgatttgttt acggcggtca tcggagggta cggccttttt ggcgtgattc 1018261 ttgatgtaac gcttgagctg acagatgatg agctgtatgt catgaagaca gaaaaaatga 1018321 attacagcac atactcagac tatttttcaa agcatgtaaa aggaaatcca gatgtccgaa 1018381 tgcatctggc gcgaatttca acagcgaaaa aaggatttct gaaagacatg tatgtcacga 1018441 attacgtatt ggctaatcat caggatcagc tgtcctcata cagcgaactt aaagaagacg 1018501 agtatacggg agccacaaag tttgcactcg gcttgtcaag acggtatgaa tgggggagga 1018561 attggctgtg ggacacacag caatcctatt tcctgagcca gaacggcaca gagatttcac 1018621 gcaataacgt catgcggtcc gaatcaaagt ttcttgagta tgaaaacaat gacaacacag 1018681 atgttttgca agaatacttt gtgcccgtga aggagtatgg gtcctatatt gatgacctga 1018741 gacaaacgct gtcggacgaa gatctgaacc tgctgaacat tacgatccgc tacgtgcaga 1018801 aaaatgaaaa ggccgacctt tcctatgcga aggacgatat gttttcgctc gtactattaa 1018861 taaacgaggg cttttcaaaa gaagaccagg cagataccgc ccgaatcatc aggcgcatga 1018921 cagacgttgc catcaagcac ggcggcagct attatctgcc ttatatgacc taccagacaa 1018981 aagcgcaaat gagacaggca tatccgaaaa gtgaagcgtt ttttcagaaa aaacgaacct 1019041 atgacccgga tgagcgcttt atgaattact tttatcagag gtataaataa tggggaaaaa 1019101 caaattaaaa tggctgacat tatcacaaag cagcgtgttt ttcgcaagca gcttaatctt 1019161 tccgttttat attctgtttg tgaaaaatat cggctcaagc tacacacagt tcggtttttc 1019221 ctacggattg ttcgggttga gcggagcgct tatttacccg ctcctcggac ggctgtctga 1019281 aaggtttgac agccgttatt ttctgcttct gaactcgtgg gggatggctg ttctgctttt 1019341 atatgtcccg catatcggaa gcgtcgttca agtgtatatc gtccaagtgc tgttagggct 1019401 ctttggagcg atgcaaaagc atggagaaaa agtgctgatc gctaatttta cagacagtgg 1019461 agagcgtgga aagaagatcg ggaattacca tttttggaca gctgtctttt cagcagcagc 1019521 cattatgctc gggggctttc tcgctgactt tttcacagtg caaatgattt tttatgcaag 1019581 ctctattcta tattttttga gtggattgat gatgatgaaa acaggctgac gcggtcagcc 1019641 tgttttttta tgcggctgaa atgcggcacc gcatcaacgt ttttgtgctg gagtcgtgct 1019701 gatttttttt gagcggaatt cccattgaac agaaaattta taaatgaata aaaatattaa 1019761 atatacgatt gaattaattt ttattcatgt tataatgtta aataatttca caaagaccaa 1019821 gagggtgaac ttgttttgaa aataggaatt gtaggtgcta caggatatgg aggcaccgaa 1019881 cttgtcagga ttctttcgca tcatcctcat gcagaggaat gcatacttta ttcatccagc 1019941 ggagaaggga atgtctatag cgagggttat cctcatctta ccggcttagc ggatcagcag 1020001 ctgaagccga ttgatatgaa tacgatcaaa cacgaaatag atatcatgtt tctcgctgcg 1020061 ccgcccggag tatcaagtga attgactcca aagctggcag acgcgggaat tacggttatt 1020121 gatctgtcag gtgatctgag gataaaagaa ccggctgaat atgaaaaatg gtataaacgg 1020181 acagcggcac cgaaggcggt gattcaagag gcggtatacg gtctggcaga actgaatcaa 1020241 ctgcaaattc aacaggcgaa actcattgcc aatccaggct gttttccaac agctgttttg 1020301 cttggcctcg cgccattggc tcaaaagaaa ctgctcgatg aatctttcgt tatcgttgac 1020361 gcgaagaccg gtgtttccgg agcgggaaga aaagcatcca tgggaactca tttttctgag 1020421 ctgaacgaca attttaaaat ttataaagtc aatgaacatc agcacacgcc ggaaattgag 1020481 caggcgctga atgaatggca gccaggtctc gggcccatta cattttcggc tcacttggtt 1020541 ccgatgacaa ggggcatcat ggcgacgatg tataccagat taacctgtga cctaaccgca 1020601 gatgacctgc atgatttata ttcggaattt taccaagatt catattttgt gagagtgagg 1020661 ccaaaaggtc agtacccgca aacgaaagaa gtgtacggca gcaatttctg tgatatcgcc 1020721 gtgaccctcg atgagagaac gaacagagtc acgatcgtct cggtaatcga taatttaatg 1020781 aagggtgccg ccggtcaggc agtgcaaaac tttaatttga tgaatggctg gaatgaagaa 1020841 actggactca ccatcacgcc aatttatcca tagaacggga gagaatcgaa ccatgattca 1020901 gttaagtgaa gatcaaattg taaaagtaac aggtgatgta tcctcgccaa aagggtttca 1020961 ggcaaagggt gtgcattgcg gactgcgcta ctcgaaaaaa gacctcggcg tcattatcag 1021021 cgagacaccg gccgtgagtg cagcagttta tacccaaagc cactttcagg ctgctccgat 1021081 caaagtgaca caagacagct taaagcacgg accgacactg aaagccgtca tcgtcaacag 1021141 cgccattgcc aacgcctgca cgggagaaca gggcttaaag gacgcataca caatgcggga 1021201 gagctttgct tcacagcttg gcattgagcc ggagcttgtc gctgtttcat caacgggtgt 1021261 catcggcgag catttagaca tggaaaaaat ccacgcgggg atcgaactgc tgaaagaaac 1021321 acctgcggga tcaggcgatt ttgaggaagc gattttaaca actgatacgg tgatcaagca 1021381 gacgtgctat gaactggcaa tcggcggcaa aacagtcacg atcggcggag cggccaaagg 1021441 ctctgggatg atacacccga acatggccac gatgctggga tttgtgacaa ctgacgcggc 1021501 aatcgaagaa aaagcgctgc aaaaggcgct tcgggaaatc actgacgttt catttaacca 1021561 aatcacagtt gacggagaaa catccacgaa cgacatggta ttagttatgg cgaatggctg 1021621 cgccgaaaac gagtgcctga cagaagacca tccagactgg ccggtcttta aaaaagcgct 1021681 cttgctcact tgtgaggatc tagctaaaga gattgccaga gacggagaag gcgcgacaaa 1021741 actaattgaa gcccaagtac agggagcgaa aaacaatctt gatgcaaacg tcattgccaa 1021801 aaagattgtc ggctcaaatc ttgtaaaaac ggcagtatac ggaacagatg ccaactgggg 1021861 gcggatcatc ggagccatcg gacactccgc agcacaggtg acggcagaag aagtagaggt 1021921 ttatcttggc ggccaatgcc tgtttaagaa taacgaacct cagccattct ctgaatctat 1021981 cgccaaggaa taccttgaag gagatgaaat caccattgtc atcaagatgg ctgaagggga 1022041 cggaaacggg agagcgtggg gctgtgacct gacctatgac tatatcaaaa ttaacgcgag 1022101 ctatcgcacg taataaaggg gagcgaaatg aagaaaacaa tcgtttttaa atgcggggga 1022161 agcgtcatcc gtgagctgtc ggaggaattt tatcaaaatc tgaaagagct gagggcgtca 1022221 ggctggaagc tggcaatcgt acatggcggg ggaccggaaa tcacaaatat gctgaaacgg 1022281 ttaaatatca agacagagtt ttcgggcgga cagaggaaaa caacgaagcc ggtgctggaa 1022341 gtggcggaaa tggttttatc cggttctgtc aataaatttt tcgttgctga gcttgccaaa 1022401 cacggactgc gagccgcggg catttctggt aaggatggcg gtcttttgga ggctgattat 1022461 ctagatccgg aaacatacgg agaagtggga gaaatcaaaa aagtcgatgc gtccatggtg 1022521 aacgcgctga tggaaaatgg catcatcccc gttattgcgc cgctgtctat gacaagcgac 1022581 tgcaaaacgc tgaatgtaaa tgctgatctg gctgcttcag cagtcgccgg agcgcttgaa 1022641 gccgataagc tgatgttcgt cacggatgtc gatggaatca tgaaggaaaa gcagcgtctg 1022701 gacgtcctga cccctaagga gattcagatg ctgatcaagc aggaagtgat cacaggaggg 1022761 atgatcccga aggtcaattc agccttgtca gctttatcag atcaggtgtc tgaagtcatg 1022821 atcgtaaacg gtaaaggatc attcttcgca gaacaaacct ttcaagggac aaaaattgtc 1022881 aaagcaaagg aggctgtttc atgagcagct tgtttcaaac ctacggccgt tgggatattg 1022941 acatcaaaaa agcaaaggga acgtacgttg aggatcaaaa cggcaaaacg taccttgatt 1023001 tcattcaggg gattgcggta tcaaatctag gacactgcca tgaagcggtg acagaggcag 1023061 tcaaaaaaca gcttgacagc gtatggcacg tatccaacct gtttcaaaac agtctccaag 1023121 agcaagcggc gcagaagctg gcagcgcata gtgcgggaga tcttgtcttt ttctgcaaca 1023181 gcggcgcgga ggcgaatgaa ggtgcgataa agcttgccag aaaagcaact ggaaaaacaa 1023241 aaatcatcac ttttcttcag tcgttccatg gccgcacgta tgcagggatg gctgcgaccg 1023301 gacaggataa aatcaaaaca ggcttcggcc cgatgcttgg aggctttcac tacctgccat 1023361 acaatgatcc ttctgctttt aaagctcttg gggaggaagg cgatattgcc gcggtgatgc 1023421 ttgaaacagt gcagggagaa ggaggagtca atccggcgag tgctgaattt ttatcagccg 1023481 tacagtcgtt ttgcaaggaa aagcaagccc ttctcattat tgatgaaatc cagaccggca 1023541 tcggacggac gggaaaaggc ttcgcatatg agcacttcgg actctcaccg gatatcatca 1023601 cagtcgccaa aggattggga aacggctttc cggtcggcgc tgtcatcgga aagaaacagc 1023661 ttggagaagc gtttacccct ggttctcacg gaacgacttt cggaggaaac atgctggcga 1023721 tggctgctgt gaatgccaca ttgcaaattg tattccagcc tgactttttg caagaggctg 1023781 ctgacaaagg ggcgttttta aaagaacagc ttgaggcaga gctaaagagc ccttttgtta 1023841 aacaaatccg aggtaaagga ttaatgcttg gaattgagtg tgatggcccg gttgctgaca 1023901 ttattgctga attgcagaca ttaggcttgc ttgtattgcc ggccggcccg aacgtgattc 1023961 ggctgctgcc gccgctcacc gtgactaagg atgaaatagc agaagccgtc agcaagctga 1024021 aacaggcaat cgctcatcat tccgctgtaa accagtgatt ttttttcgat ataaaggcat 1024081 aaaaattcat ttttataatt aattattcat caagaggtgg gctgttagat ggaaggttat 1024141 ttagtgttag aagatgggac atcgttcagc ggcgagctgg acggtcatga aaactgcacg 1024201 ggagaagctg tttttttcac aggaatgaca ggctaccagg aagtgctgac agatccatca 1024261 tataagggac agattattgt atttacctac ccgctgattg gcaactacgg cataaatgaa 1024321 aaggattttg aaagcaagaa accgcaagta aaagccgcgg ttgtctatga ggcgtgtgat 1024381 cacttttctc attatgaagc ggtatacagc ctcaaggagt atctacagaa atggaatatt 1024441 ccgctgttaa cccatgttga tacgagggct gtcgtgaaga aaatccgggc aaacgggacg 1024501 atgggtgcga cagtcacagc ctctaaagaa ggagctgaga ttgcccttca accagagaat 1024561 gtggcagagc aggcttccgc ccaggaaatc agcacattcg gcgacgggaa taaacatatc 1024621 gctctcattg attttggcta taaaaagtca atcgcatcat cacttgtcaa acgaggctgc 1024681 aaggttaccg tggtgccata ccagcaaatg gaggccgtat acaacatcaa acccgatggg 1024741 ctatcgaacg gacctggaga tccgaaagcc attcagccat atttaggaaa gatcaaaagc 1024801 atcatcagcc gctttccgac tctaggcatt tgtctcggac atcagctgat cgcgctcgcg 1024861 tttggaggga atacttttaa gctgccattc gggcacaggg gagctaatca tccggtcatc 1024921 gaccgtaaga cgaaacgggt ctttatgaca agccaaaacc acagctatgt ggttgatgaa 1024981 cagtcgatta atgaagaaga gctcaccatc aggtttcatc atgtcaatga tacgtcagtt 1025041 gaagggcttg cccataaaaa actgcctgtc atgagtgttc aattccaccc ggaagcccat 1025101 cccggacctg cggaaagcga atggattttt gatgattatc taaagaatgt gataccagca 1025161 aggagagaaa tcgcgcatgc ctaaagacac cagtatttca agcatattag taattggctc 1025221 aggcccgatc atcatcgggc aggcggcaga atttgattat tcaggcactc aagggtgcat 1025281 cgcgctgaag gaggagggct accgggtaat tctcgtcaac agcaatccgg cgacaattat 1025341 gactgatgaa gccttcgctg atgaaattta ttttgagcct ctgacagcag aaagcctgac 1025401 agccatcatt aagaaagaac ggcctgatgg gcttcttgcc aatttaggcg gtcagaccgc 1025461 gttgaattta gcggtggagc ttgaagaaac gggtgtttta aaagagcacg gcgtcaaact 1025521 cctcggcaca tccgttgaaa cgatacaaaa aggagaggac cgggaaaaat tccgttcgtt 1025581 aatgaatgaa ttaaaacagc ctgtgccgga gagtgaaatt gttgataacg aggccgatgc 1025641 cctccatttt gcggaatcca tcggttttcc tgttattatc agaccagctt acacattagg 1025701 cggaaagggc ggaggaatcg cccctgataa agaagccttt acagctatga ttaagcaggc 1025761 gctattagca agcccgatca atcaatgcct tgtcgaaaaa agcattgccg gctttaaaga 1025821 aattgaatat gaagtcatgc gtgacagcaa taacacatgc attaccgtct gcaatatgga 1025881 aaatatcgat ccggtcggcg tgcatacagg tgactctatc gttgtggcgc cgtcacaaac 1025941 attgacagac gaagactatc aaatgctgcg gacagcaagt ctgacgatca tctcagcact 1026001 tgatgttgta ggcggctgca acattcaatt cgcgcttgat ccattcagca agcaatatta 1026061 cgtcattgaa gtgaatccgc gtgtaagccg gtcatcggct ctcgcatcta aagcgaccgg 1026121 ttatccgatt gcgaagatgg ccgcgaaact ggcagtcgga tacactcttg acgagctgaa 1026181 aaatccgctc acaggctcga cttacgcaag ctttgaaccg gcactggatt atgtgatcgt 1026241 caaatttccg cgctggccgt ttgataaatt caaaaacgca gaccgcaagc ttggcacaaa 1026301 aatgaaagcc accggtgaag tgatggcgat tgaacggaat ttagaagcgg cgatacaaaa 1026361 ggcagccgcg tcgcttgaat taaaaaatat cgggacacac cttccagagc tcagcgggtt 1026421 gtcaattgat acgctatggg atttggcaat cactccggat gaccgcagat ttttcgttgt 1026481 catggagctg ttgagccgca gcgtctcgat tgatgacatc catgaaaaaa caaaaattga 1026541 tccgtttttc cttcatacct ttgacaacat catcaaattg gaaaaccgcc tgatggaagc 1026601 agggagcgat ctctcttttg aattattgaa gaaagcaaag gaaaagggat tctcagacgc 1026661 aacgattgcc tcgctgatca gcaaaacaga agaagaggtg cgcgcgcttc gcaaggagat 1026721 gggcattacg ccttccttta aaatcgtaga tacatgcgcg gcagagtttg atgcgaaaac 1026781 aaactatttt tactccacat atttcggaga gaccgatgga gacatcagcc gcaaagagaa 1026841 aaaacgcgcg ctcattatcg gatcaggccc gattcggatc ggccaaggcg ttgaatttga 1026901 ttacagtgct gttcacggtg tgctgacact gcaagagctt gggttcgaaa ccatcatgat 1026961 taacaataac ccggaaactg tcagcaccga ttatgaaatt gcggaccgcc tgtattttga 1027021 accgatgaca acggagcata ttgtaaacgt ggcggagcag gaaaatattg attttgcaat 1027081 tgtgcaattt ggcggtcaaa ctgcaatcaa tgctgctgaa gcgctcgaaa aagccggcat 1027141 tactcttctt ggcacatcat ttcaaacgct cgacgtgtta gaggatcggg atcaatttta 1027201 tcagcttctt gacgagctgg gattgaagca cgcaaaagga gaaattgctt atacaaaaga 1027261 agaagccgct tcaaaagcga gtgagatcgg ctatccggtg ttaatccgcc catcttacgt 1027321 tatcggcgga atgggcatga tcattgttga ctcgcaagcc cagctttctc agctgctgaa 1027381 tgatgaggac agcatgccat acccgatttt aattgatcag tatgtgtctg gaaaggaagt 1027441 cgaaattgat ttgatttccg acggcgagga agtctttatc ccgacatata ccgagcatat 1027501 tgaacgggca ggtgtccatt caggggacag ttttgccatt cttcccggac cgtccatcac 1027561 gagcgggctg cagcagggca tgaaagatgc ggcacaaaaa attgcccgaa aactttcatt 1027621 taaaggcatc atgaacattc aatttgtgat cgacaatgga aacatactcg ttcttgaagt 1027681 gaatccgaga gcgagccgca cggttcctgt cgtcagcaaa gtaatgggcg ttccgatgat 1027741 tccgctcgcc acacgtctgc tggcgggagc gtccttaaaa gatctaaatc cggcagttca 1027801 aaatcatcat ggagttgccg tgaagttccc tgttttttct tctcatgcga tccaggatgt 1027861 ggatgtcaag cttggaccgg aaatgaaatc aacgggagaa ggcatgtgtg tcgcatatga 1027921 ttctaacagc gccttgaaaa aaatctatac aagagtctgg agtcaaaaag gaagcattta 1027981 tttgcaaaac gttccggaag atgtgaagga gttagcagaa aacgcaggtt ttacaataca 1028041 tgaaggaaca tttgcctcat ggatggaaca ggaaggaaac tcgctccaca ttaatctgag 1028101 cggttctgaa gaagcacgca aagaacgttt ggaagccatg acgcacggca tccccgtctt 1028161 tacagaagaa gaaactgtgc gggcgttttt acaaagcggt tcaggccatc cgcagcctgt 1028221 atctctcaaa gacctctata aaaaggaagt ggcatcatgc acacagtgac gcaaaccagt 1028281 ttatacggaa aagatttatt aacgttaaag gaccttagtg aagaagatat aaacgccttg 1028341 ctcgcagaag ccggtgagct gaaacaaaac aaaattcagc ctatattcca tggcaaaacc 1028401 ttggcgatga tttttgaaaa atcatcaacg cggacccgtg tttcatttga agcgggcatg 1028461 gcgcagctgg gcgggagcgc cctctttcta agccagaaag atctgcagct ggggcgcggt 1028521 gagactgtcg ctgatacggc aaaagtgctg tcaggctatg tggatgccat catgatccgg 1028581 acctttgaac atgaaaaggt ggaggaactt gccaaagaag ctgacattcc ggtgatcaat 1028641 ggacttaccg ataaatacca cccatgccag gcgctggcgg atctcttgac gattaaggag 1028701 ataaaaggga agcttaaagg cgtaaaagtc gcgtacatcg gtgacggaaa taacgtggcg 1028761 cactccttga tgatcggctg cgcgaaaatg ggctgtgata tctcgatcgc ttcaccaaag 1028821 ggatatgaag tgttagatga agcagctgaa gcggcaaaga catatgcact tcaatccggc 1028881 tcttctgtca cgctgacaga tgatccgatt gaagctgtaa aagacgcgga cgtgatttat 1028941 tctgatgtgt ttacaagcat ggggcaggaa gcggaagagc aagaacgtct tgctgtcttt 1029001 gcgccttatc aggtgaatgc ggcgctggtc agccatgcca agcctgacta tacattttta 1029061 cattgtctcc ctgcgcatcg cgaggaagaa gtgactgcgg agattattga cgggccgaac 1029121 tctgcagtgt tccagcaggc ggaaaaccgt cttcatgtgc aaaaagcact gctgaaggcc 1029181 attttatata aaggggaatc atcaaaaaac tgctgagcca aactcagcag tttttttgat 1029241 ggcaacatat tcacagccgc ttaggcgcat actacagcaa aaaggaaaag gaggaaaaac 1029301 agtgggacag cagcaccaat tccggcccgg acagaaagcg cctaataacg gtgtctacgt 1029361 agaaatcggc gagacaggga gcatggttaa aaaccctcaa aaggtccatc tgtcagcagg 1029421 ggaaatgttc cccgaaacat caaaccacaa ccggctgtgg acctacaaaa gaaagccgtg 1029481 accactaaaa aacccaaaac aataaatgtt ttgggttttt ggctttttaa tgctggcttg 1029541 catttttgtt cataggcatg atttctgcta aaaccatgat taagacatac agtacaacag 1029601 caatgacaga tgatgttttg aaattatacg taacgctgtt catgcttgca accaagtagc 1029661 atgccatatg tgataaaagg aacgtccaaa taaaggcaat aatatatcgc acgtttccac 1029721 ctcgtccttc tcattctatt ctaaaagtta tcataccata caaaaagcga agggggaatc 1029781 caattttagc agaaagtgag gtgacaaaag agtctgattc gtcacacttt aatggtaaaa 1029841 tataaaacgt caatcagtat aatagccaaa aatgtaaaag gctaggactt taccttattc 1029901 gtttcttttc tatttacata agatagcgtg agatgaagtg tgaaaggagg cgggcaagcg 1029961 atgggaataa cggaaagata ctttcaactg ggaacggagc ataatgtcat tcatctgccc 1030021 tatcgcccga acggcttcgg catctttatc ttgggggaca gaacccactt tgtcggacat 1030081 gattcaagct tttggcagca gcattatggc agaaatcagc ttctgagcat gttgatgaat 1030141 gaaggataca ctctttttaa cagcaatctg ttcggaaggc attggggggc ggaaaaagca 1030201 gtcacctatg ccaaacagct gatacattct gtgctgaagc aggaaatcct caatccgaag 1030261 attcatattt tagcagaagg catgggtgct ctcgtggccg atgaactgct tcgtttttcc 1030321 ccggatcata tccgctcagc cgcaatgttg aatccttgtc tcgatcttca ggcacattat 1030381 gaatcggaaa aagaaaataa atttttctat aagcaatttt tgaaagaagt atcgaaaagc 1030441 tacggaattt ctgaaaaaga agcggaagcg attcgttata aaacaattca aagctacccg 1030501 agcggcgtac cggttcatat atggcagcgt atgaccggag ctccatatcc ctacagcgta 1030561 catgcggaag ttttcaagga aaaacagcaa aagcaaggct caccggtcga catgacattt 1030621 catttatttg agcatccaag cagaatttat gcatcaattt gcaaattctt tcatagtcat 1030681 gaaaaagaat tatagagaat ataatgacaa cagccttctc ttttgcggag gctgttttgt 1030741 tttgggaaat gaaaaaccgg aagggcggca gatgcaatgg aatcaacgct gattgtaggt 1030801 gcggacgaat ttttcggcct ttcattatgt gagcgaatga tggatgaagg catacatgtt 1030861 gacgttgttc tggcggaaac agaagataaa atgagacaaa tgtacttaga agaaagactc 1030921 atgtggcttg ggagaaatga actctttcgc cagcttgaac acattggaga ccaaaattat 1030981 gatacaattt gtatccagtt cggaagtttt ttgcctttag accaatatga ttctccttat 1031041 attttagtat atgaagaaga ccgaaaagaa tgggataaac gtgaaaaaac aggctcggaa 1031101 aaaaccgtga tcctgccgaa aatgtacggg ccatggaaag aagaaacaga ggaagacggc 1031161 tattacacaa acgacgtggc tgacgagttg ctgagattcc tgttagaacc aagccgtcat 1031221 agcaaagatc agctttttga attgcaagtc acagagaaaa cctcaaaaga agaagcaaaa 1031281 acaaaaatta tcgagtggaa aagacaattt tcatcaattt tcgacaaata ttaagaaaaa 1031341 ccttccatgt ttcgagtttt ctagatacaa taaacgtata aaaataatac atgttatagc 1031401 ttgtcaaaag gagttgaaca tgacttgatc acaaggcttg tcatgatctt ttctgtcctc 1031461 cttttattga gtggatgtgg acaaactccg ttcaaaggaa aaattgagaa ggtcggcatg 1031521 ctctttcctg atacgattaa tgacctcgta tggggcacaa aagggtataa aggattactg 1031581 aatatacaat ccaaatacaa tgtggacgtc tattataaag aaggcgttaa aacagaagaa 1031641 gatatcataa atgcgattga ggattttcat aagaggggcg tcaatctgct ctacggccat 1031701 gggagtgaat atgctgaggt gtttaacttg gtcggcgaag attatccaga tatggaattc 1031761 gtcatttcca atgcgaaagc gaaagctgat aatgtaacaa gtgtccattt tagcggggaa 1031821 gcaatgggct tttttggagg aatgactgct gcccatatgt cgaaaacgaa tcaggtcggt 1031881 gtaattgctt cctttacgtg gcagcctgag gttgacggtt ttatcaaagg ggccaagtat 1031941 gaaaatccgg atatagaggt aaatacgaaa tatacggatc attgggatga tgatacaaca 1032001 gcagtaaagc tttatcagaa aatgaagaac gaaggcgcgg atgttgtgta tcccgccgga 1032061 gacgggtata atgttcctgt tattcagcaa atcaaaaaag acggtcttta tgccataggc 1032121 tacgtcacag atcaatcgga tctgggcgag aataccgtat taaccagcac ggtgcaaaat 1032181 gtggacaagg cctatgaaat cattgctgaa caatttaata aaggcaccct tgagggcggc 1032241 gatcattact acgacctgaa cacgggagtc gttgagatgg gaacattcag cccgctcgtc 1032301 gatcaagact ttcagcaaag aatcgccaag ctgatcaaaa catacaacaa aacaggcgag 1032361 ctgccaaaaa acgagtaatg gagtgacgtc acatgcagca cgaaaaatca cttgaattct 1032421 tgcaaattgc catgaaatat ctccctgaag cgaaagaaca gcttgagaaa tcaggcattg 1032481 agctctcaat ggaggccatc cagccgttta tgaatctatt tacaacggta atggcggaag 1032541 cttatgagct tggcaagtct gacgctaaat ctgaaacaga ataagaagaa gccacttttt 1032601 tgaaagtggc ttttcacatg attttctttt taatagcgga gagcatgggc gcaagctcct 1032661 ttaaagcggg cttgatttga tcaagagagt tcataattga accgatttgg tccataatat 1032721 gcatgtaatt aatcgtctct tcgtcgtttg tctgagaaac ctgagaaact tcctcttgct 1032781 gttcctcctc cttctcttct gttggttttg ctgcatcgcc gaacatcatt cttgaaaaca 1032841 catccaactg catacgcctc ctttccatat accatactct atgagtaaga tgaactgata 1032901 gtttagacga atatattgcc atgtgaaaaa aaataggata gaattagtac ctgatactaa 1032961 taattgatca caacctgatt gatcttctaa atttaagata taaaggagtc ttccctaatg 1033021 aaagctggaa tacttggtgt tggacgttac attcctgaga aggttttaac aaatcatgat 1033081 cttgaaaaaa tggttgaaac ttctgacgag tggattcgta caagaacagg aatagaagaa 1033141 agaagaatcg cagcagatga tgtgttttca tcacatatgg ctgttgcagc agcgaaaaat 1033201 gcgctggaac aagctgaagt ggctgctgag gatctggata tgatcttggt tgcaactgtt 1033261 acacctgatc agtcattccc tacggtctct tgtatgattc aagaacaact cggcgcgaag 1033321 aaagcgtgtg ctatggatat cagcgcggct tgtgcgggct tcatgtacgg ggttgtaacc 1033381 ggtaaacaat ttattgaatc cggaacctac aagcatgttc tagttgttgg tgtagagaag 1033441 ctctcaagca ttaccgactg ggaagaccgc aatacagccg ttctgtttgg agacggagca 1033501 ggcgctgcgg tagtcgggcc agtcagtgat gacagaggaa tcctttcatt tgaactagga 1033561 gccgacggca caggcggtca gcacttgtat ctgaatgaaa aacgacatac aatcatgaat 1033621 ggacgagaag ttttcaaatt tgcagtccgc caaatgggag aatcatgcgt aaatgtcatt 1033681 gaaaaagccg gactttcaaa agaggatgtc gactttttga ttccgcatca ggcgaacatc 1033741 cgtatcatgg aagctgctcg cgagcgttta gagcttcctg tcgaaaagat gtctaaaact 1033801 gttcataaat atggaaatac ttctgccgca tccattccga tctctcttgt agaagaattg 1033861 gaagccggta aaatcaaaga cggcgatgtg gtcgttatgg tagggttcgg cggaggacta 1033921 acatggggcg ccattgcaat ccgctggggc cgataaaaaa aggtgaggtg cacacaagat 1033981 gactaaaaaa agagtagttg ttacaggact tggagcatta tctccacttg gcaacgacgt 1034041 cgatacaagt tggaataacg caatcaacgg tgtgtccgga atcggtccga tcactcgtgt 1034101 tgacgctgaa gaatatccgg caaaagttgc cgctgaatta aaagatttta atgttgaaga 1034161 ttatatggat aaaaaagaag ccagaaaaat ggaccgcttt acacaatatg cggttgtggc 1034221 tgcgaaaatg gcggttgaag atgcagatct taacattacc gatgagatcg cgccgagagt 1034281 cggtgtttgg gtaggctccg gtatcggagg acttgaaaca ctagagtctc aatttgaaat 1034341 cttcttaaca aaaggcccaa gacgggtaag cccgtttttc gtgccaatga tgattcctga 1034401 catggcgaca ggccagattt ctattgcatt aggagcaaaa ggggtgaact cttgtacggt 1034461 tacagcatgt gctacaggaa cgaactccat cggtgacgcg tttaaggtta ttcagcgcgg 1034521 tgatgcagac gtgatggtca caggcggaac agaagcgccg ctgacaagaa tgtcattcgc 1034581 cggctttagt gccaacaaag cgctgtctac taatccagat ccgaaaacag cgagccgccc 1034641 gtttgataaa aaccgtgatg gctttgtcat gggggaaggt gcagggatta tcgttcttga 1034701 agaacttgag catgccctgg cccgcggcgc taaaatttac ggagaaattg tcggctacgg 1034761 ctcaaccgga gacgcttatc atatcacagc gccggcccaa gacggtgaag gcggagcgag 1034821 agcgatgcaa gaagccatta aagatgcagg cattgcacct gaagaaattg attacatcaa 1034881 tgctcacggg acaagcacgt attacaacga caaatacgaa acaatggcga ttaagaccgt 1034941 ttttggcgag catgcgcata aacttgcggt aagctctaca aaatcgatga caggccacct 1035001 cttaggagca gccggcggta ttgaagccat tttctctatc ctggccatta aagaaggcgt 1035061 gattccgccg acaatcaata ttcaaacacc tgacgaagaa tgtgatttgg attatgtgcc 1035121 tgatgaagcc cgcagacagg aacttaatta tgttctcagc aactcattag gattcggcgg 1035181 acacaacgca acattaatct ttaaaaaata tcaatcataa tcaagccaaa ccggctgccc 1035241 ttaaagggta gccggttttt tttgtgtgca taggattaaa agaggaggcg atcacatgag 1035301 tgtagaacaa acatatagct ggctcaggaa ggccggttca atagatgatt tggcgcatta 1035361 cattatcccg cttttttcag gtgcggagaa aaagaactgg aagggcattc tggggcatct 1035421 tcagcatcat gggatgttta aaaacataaa agagggtatt cagacggttt ccaagctgaa 1035481 ggaaaaaggt ttttacggac atatccaaaa ggaagaacag tacctcaaaa acaaatggca 1035541 aggtcctgat gtaccaattg ttacgctgcc ggttgatgaa cgaaacagga gaatccgttt 1035601 agaattcgga tcaaaatcag gactcgcctt tcaagacaaa atgttccttt ttctttcgtc 1035661 agatttagat tttgggtcgg tatctgccct tatgacgcat gagtatcatc acgtttgccg 1035721 gttaggtcat ctgacaaaag aggaaaagga tgtcacatta cttgatacaa tcatcatgga 1035781 agggctggcg gaatatgctg tttatgagag gttcggccga agtcaaacgg ctgaatggac 1035841 gacttggtat acaccggaac agcttcaggc tttatatgaa aaaaagattg cgccccatcg 1035901 ggatatcaaa cgggataatc gattatttcc ccagctgtta ttcggcaaag gatatcagcc 1035961 aaaaatgctt ggatacgcag ttggattcaa tattgtaaaa aaatatttaa ccgccagcaa 1036021 ggcaagcacc gcagacgggc tgtccattcc tgctgagacc tttttggatg caatgcttta 1036081 aaaggataaa ataatggaat ttcattaata atattacatt tatcctaaaa aattcttgat 1036141 tttgcaaaat gattgtaata atatacaact ataaaatttt tcgataattc aatattattt 1036201 attatttctg aataaaggga ttgctttctc ttgaaaacgt ttgacaacaa gaggggggaa 1036261 aggggagcta gcatgagcac acttttagaa gtgaataatt taaagactta ttttttcagg 1036321 aaaaaggagc cgatccctgc ggttgacgga gtcgattttc acatcagcaa aggcgaaacc 1036381 gtcgcgcttg taggtgaatc gggctccgga aaaagcatta cttctttatc aattatgggc 1036441 ctcgtccaaa gctcaggcgg aaaaatcatg gacggctcta ttaaactcga agacaaagac 1036501 ctcacctcat tcactgaaaa cgattattgc aaaatccgcg gtaacgaagt atccatgatc 1036561 tttcaggaac caatgacctc ccttaatccg gtgttaacaa tcggagaaca aattaccgaa 1036621 gtgctgattt accataaaaa catgaagaaa aaagaagccc gtcaacgagc tgttgaactc 1036681 ttgcagatgg tcggtttctc ccgggcggag caaattatga aggagtaccc gcatcggctg 1036741 tccggcggta tgagacagag ggtgatgatt gccatcgcac tgagctgtaa tcctaaactg 1036801 ctcattgctg atgaaccaac gacagcgctg gacgtgacaa tacaagccca ggtgctggag 1036861 ctcatgaaag atctctgtca gaagttcaat acatcgattc ttctcatcac acacgactta 1036921 ggtgtcgtgt ctgaagctgc cgatagagtg attgtcatgt actgcggaca agtcgtagaa 1036981 aacgccactg ttgatgactt atttttagaa ccgcttcatc cgtatacaga aggcctgctt 1037041 acgtcaattc ctgttataga tggagagatt gataaattaa atgcgattaa aggcagtgtg 1037101 cctacaccgg ataatctgcc gccggggtgc cgttttgccc caaggtgccc gaaagctatg 1037161 gataagtgct ggacaaatca gccttcgctt ttgacacaca aaagcggaag aacggtgaga 1037221 tgctttttat atgaggaaga gggtgccgaa caatcatgac agcagctaat caagaaacaa 1037281 tcttagagct tcgtgacgta aaaaaatact ttccgatccg gtcaggcctt tttcaaagaa 1037341 aagtcggtga tgtaaaagcg gtggatggtg tttcattttc gttaaaaaaa ggagaaacac 1037401 tcggaatcgt tggagagtcg ggctgcggaa aatcgactgc cggcagaacg atgatcagac 1037461 tgtacaaacc gacagagggc caaattcttt ttaaagggca ggatatttcc aatctgtcag 1037521 aggagaagct gcggaagagt gtccgcaaaa atattcaaat ggttttccaa gatccatttg 1037581 cttcgttaaa cccgagaaag accctgcgtt ccatcataaa ggagccgttt aatacgcaca 1037641 acatgtatac catgcgtgaa cgaaacgaaa aagttgaaga gctgcttgca agagtagggc 1037701 ttcacccgtc gtttgccggc cgttatcccc atgagttttc aggcggccag cgtcagcgga 1037761 tcggcattgc cagagcactc actttgaatc cagagctgat cattgcagat gagccggttt 1037821 ccgcacttga tgtatccatt caggcccaag tgattaactt gatggaggaa ttacaggaag 1037881 aatttaatct tacgtatcta tttatctctc atgatctgag tgtcgtccgc catatcagcg 1037941 acagagtcgg agtaatgtat cttggcaaaa tgatggaact gaccggcaag catgagcttt 1038001 atgacaaccc gcttcaccca tatacccaag cgcttttatc ctccgttccg gttacaagaa 1038061 aaagaggttc tgtcaaacgt gaacgcattg tcctgaaggg agaactgcct agtccggcca 1038121 acccgccaaa aggctgcgta ttccacacaa gatgtcctgt tgcaaaaccg atatgcaagg 1038181 aacaaatacc agaatttaaa gaagctgctc ccagccactt tgtggcttgt cacctttata 1038241 gctaatgttg cccgcacagc tttgagaggg ggtatgcaca ctacataaac aacagcctag 1038301 aagaacgaac atttcaagag ggggaatatc taatgaaaag acggaaaacc gcactgatga 1038361 tgctaagtgt attgatggtt ctggccatct ttttatcagc ctgctcggga tcaaaatcaa 1038421 gcaacagcag cgcgaaaaaa tcagcaggca aaccgcagca aggcggggat ttggttgttg 1038481 gttcaatcgg agaacccaca ctttttaact ctctgtattc taccgatgac gcaagtacgg 1038541 atattgaaaa tatgctgtac agctttttaa cgaaaacgga tgaaaaacta aatgtgaaat 1038601 tgtcactcgc tgaaagcatt aaagaattag acggcggcct tgcatatgat gtgaaaatta 1038661 aaaaaggcgt taagtttcat gacggaaaag aactgactgc agacgacgtc gtatttacgt 1038721 acagtgtccc tttaagcaaa gattacaagg gagaacgcgg ttcaacatat gaaatgctga 1038781 aatccgtaga aaaaaaggcg attacgaagt cttgtttaag ctgaaatata aagacggtaa 1038841 tttctacaac aatgcgttag acagcacagc tattctgccg aaacatattc tcggtaatgt 1038901 tccgattgct gatttagaag aaaatgagtt taacagaaag aaaccaatcg gttcaggacc 1038961 atttaagttt aaggaatgga agcagggcca atatattaag ctcgaagcga atgatgatta 1039021 ctttgaagga agaccgtatt tagatactgt gacgtataaa gtcattcctg acgcaaatgc 1039081 tgccgttgct cagctgcagg caggcgatat taatttcttt aatgtgcccg ccactgacta 1039141 caaaacggct gaaaaattca acaacctaaa aatcgttact gatttggcat taagttatgt 1039201 gtacatcggg tggaatgaaa aaaatgaatt attcaaggat aaaaaggttc gtcaagcgct 1039261 aacaaccgct cttgaccgcg agtcaatcgt cagccaagta ttagatggag acggcgaggt 1039321 agcttacatt ccggaaagcc ctttatcttg gaactatcct aaagatatag atgttccgaa 1039381 atttgagtac aacgagaaaa aagcgaaaca gatgcttgca gaagccggct ggaaagatac 1039441 gaacggtgac ggcattctgg ataaagacgg aaagaaattc tcgtttaccc ttaaaacgaa 1039501 ccaaggaaac aaagtccgtg aagacatcgc tgtcgtcgtt caggaacagc tgaaaaaaat 1039561 cggcattgaa gtgaaaaccc agatcgttga atggagcgct ctcgttgaac aaatgaatcc 1039621 tccgaattgg gattttgatg caatggtcat gggatggagt ttatccacat tcccggatca 1039681 atatgatatt ttccattcaa gccagattaa aaagggtttg aactacgttt ggtataaaaa 1039741 tgccgaagcg gataaactca tgaaagatgc aaaatcaatc agtgacagaa agcagtattc 1039801 aaaagaatat gagcaaatct atcaaaaaat tgcggaagat cagccgtata cgttcttgta 1039861 ttatcctaac aaccatatgg caatgccgga aaatcttgaa ggatacaaat atcatccgaa 1039921 acgtgatttg tataatattg aaaaatggtg gcttgcaaaa taaatttccc ttaaagggga 1039981 gggagagcgt tttctccctc ttctgttttt aataaggaaa gtaaaggggg acaagtatat 1040041 ggctgcatat attatcagaa gaaccttaat gtctatcccg attttattgg gaattacgat 1040101 tttatcattt gttatcatga aagccgcgcc cggagatccg atgacattaa tgatggaccc 1040161 gaaaatcagc caggctgaca gagagcagtt tattgaaaaa tacggtctga atgatcctca 1040221 gtacgttcaa tatttaaagt ggctaggcaa catggtgcag ggtgatttcg gaacgtctat 1040281 tgtcagaaaa ggaacgcctg tttcagaatt gattatggca agactaccca atacgctcct 1040341 gctgatgctg gtttcaacga ttttggctct tatgatttct attccgttcg gtgtcctgtc 1040401 ggcaaagcgg ccgtattcaa aaatcgacta tggcattaca tttacctcgt ttataggcct 1040461 ggctattcca aacttttggt ttggattaat tttgattatg gtgttatcgg taaatctcgg 1040521 ctggtttcca actgggggtg tcgagacact gaataccgaa ttcaatatat ttgaccggat 1040581 tcatcattta attctgcctg cattcgttct agctacagct gacatggccg gactgacgag 1040641 atacacgaga tccaatatgc ttgatgtatt aaatcaagat tatattcgca cagcgagagc 1040701 aaaaggattt aaagagaaca gagtgctatt taaacatgga ttgaggaatg cattattacc 1040761 cgtcattaca attttcggtt tgatgattcc ttcatttatc ggcggatctg tcgttgtcga 1040821 acaaattttc acttggccgg gattaggaaa gctgtttgtc gattcagcat tccagcgcga 1040881 ttatccggtt atcatggcaa tgactgtgat ctcggcggtt cttgtcgttg tcggaaacct 1040941 cattgcagac atcctttacg cgattgttga tccgcggatc gaatattaaa aggagggaaa 1041001 cagagatgtc agagctgcaa acaactccct cgccggagat caggctgaaa gaaaatattt 1041061 cgaaaaagcc agaaacaatg acaaagattt tctgggaaaa attctcgaaa aacaaactgg 1041121 ccattttagg tgccgttatt ctttttatca ttattatgtc tgctgttttc gcccctttaa 1041181 ttgcacctta tccccaagag cagcaaagcc tgcttgataa atataaggcg ccgggccttg 1041241 aacatctgat gggaacggat aaatttggac gtgatatttt cagccggatc ctatatggag 1041301 cgcgtgtctc tttattggtt ggatttgcgt ccgtagtcgg ttcgattttg atcggaacgg 1041361 ttttaggagc attagccgga tatttcagag gaatagtgga tgctgtcatt atgcgtgtag 1041421 ttgacattgt gttatccatt cctgatattt tcttgttgat cacgctggtc accatcttca 1041481 agccgggtgt ggacaaattg attttaattt tctgtctcac aggatggacc acaacagcac 1041541 gattagtaag gggagaattc ttgtcgctcc gttcaaggga atatgttctt gctgctaaaa 1041601 caattggaac aaaaacgcac aaaattattt tttctcatat cctgcccaat gcgttagggc 1041661 cgattatcgt gtcagctacg ctgaaagttg ggtctgttat tctagctgaa tcggcgctaa 1041721 gctacttggg ctttggaatc cagccgccaa tcgctagctg ggggaacatg cttcaagacg 1041781 cacagaattt cacagtaatg attcaagcat ggtggtaccc gttatttccc gggctattta 1041841 ttttaatgac cgttttatgc ttcaactttg tcggtgatgg cctgcgggat gcgcttgacc 1041901 cgaaaaatat taaataaaaa tgaatatcat atctgttata aaatatcacc aaatcagaaa 1041961 aaagcaggtc tcctttagtc agaaaatata caaagagatc tgctttttat gattcttaca 1042021 taaacccagt gattccagat ttcctcaatc tctttggaat aatttctcta tcccttgcct 1042081 atactgtgga caacagtttt tataaaagtg aggggttaga gatgttattt cttcatgatg 1042141 tgtgggtcaa ttggtttgaa ggggaagaaa atggctacaa tgtatgccac tttcacgaat 1042201 ggcgcaagga agatacggtt gagcttttgg atcaggtgcc gctgttaagg gtgccgtcag 1042261 tactgtttca ttacatagaa aacgatttgt cagagcttcc gaaaggtttg cttgaagacg 1042321 tacatcagaa atcgtacatt cgaaaaaatc atgagcggac aaagcttgag tattgttttg 1042381 tcgtaacaga cggaatcggc attttagctg ttgacacgat cggctacacg atccctgtca 1042441 gaaaaagccg tctaatccca agacaggagc agctcgttta tgaaatggta aaagatgtag 1042501 agcctgaaac atatgaattt gagccaaaga agctggaatc ctccaaggaa tatcacatct 1042561 tatcattagc accagaacat gtcagaggac tgacaagaaa agaacggcaa attaagcagc 1042621 tgatgtttat ggcgcttgac caattaaaag ggctgaaaaa ccgagcggaa attggctact 1042681 ggtacacaga gtggaatccg catatgtatg aacaaatcaa aaggatgagc tttgaagaga 1042741 tttgggacat gctgtataac gaaacaattg aaggctggtc ggacaaacac ctagcttttt 1042801 gcgaaaacct aataaaagga cagccttttt tcgaaaagct ttgggaaatg gaaaacgaat 1042861 caaaggtcaa ctgaaaaaaa ccgctctttg caaagagcgg ttttttgatt agcgtctttt 1042921 tcttccaaga cccatggcat tctccatttt tttcagcatt ttgtttgctg tccgattcgc 1042981 tcgttccgcg ccttcatcaa gaatccggtc taattcttca gattctatca gctcgtaata 1043041 gcggtcctgg atcggtttta atgcgttcac tacgacttct gccaaatcac ctttaaactc 1043101 gccgtagcct tttccttcgt actttgcttc aagctcttca attgtcgtat tgccgaggat 1043161 tgaataaatt gtaagaaggt tggaaacgcc cggtttgttt tccttatcaa atttgacaat 1043221 gccttcagaa tccgttactg cgcttttgat tttcttttca agctgcttcg gctcatccag 1043281 caatgtaata taagctttct gattcggatc agatttgctc attttcttca gcggatcatt 1043341 cagagacatg atacgtgcac cgacttttgg aattttcact tccggaatcg taaagatgtc 1043401 gttgtatttt ttgttgaagc gttctgcaag attccgcgtc agctcaaggt gctgcttttg 1043461 atcctcgccg acaggtacaa gatccgttcc gtacagcaga atatcagcgg ccatcagcgg 1043521 cggatatgtt aacaggccgg agacgacagc ttcattgcct ttggatttgt ccttaaattg 1043581 agtcatccgc tcaagctcgc cgatataggc gacacactgc atcatccatc cggcctgcgc 1043641 atgtgcgggg acctctgact gaataaacaa tgttgctttt tctggatcaa gtccgacagc 1043701 taagtaaagc gccgcgagat tgcggatatt ctttctaagc tcaagccggt cttgaggaac 1043761 agttatcgca tgctgatcga cgatgcaaaa atagctgtta taatcatgct gcagttcgac 1043821 aaactgcttc attgcaccga tatagttgcc gagcgtcact gagccgcttg gctgaatgcc 1043881 tgaaaaaatc gtttgtttca tgaaaacatc aacctcattt cttaaaacat aataaaaaag 1043941 gctcattctt cccctgtaaa aaagggacga atgaaccgtg gtaccaccct gattattcca 1044001 ttaaaatgga atcactctga cgtttgtaac ggagactgct ccggctgagc ctactttttt 1044061 ccagttcggt cagctgctcc aaagtccatt ccacattgcc cgttatctgc tcccagcacc 1044121 gcagactctc ttcaaacagg tgaaacgtgt actactcttt ttcatagcaa gcttttcttt 1044181 tgattgcttc attataaatc aattataacc aattgtcatc atgaaaaaac attctttttt 1044241 ccagtaaaat tgtaataata taaataacac gagtgctgta aaatccttaa atgataactg 1044301 ctatcagcgt aaaaacaggc agatattata tgtaaaaagc aatatgggca gaaaacacat 1044361 gaaaaagttt ttaatcaatt tatgctttaa atggtagaag gatattatgt tcatggaaga 1044421 aaaactaacg aagtttaaat attttaaatt gataaaataa tattgcaata aattatttgt 1044481 ttcattataa tgaacttgtt cactctattg ttacagcttt tttacaaaaa taatcagaaa 1044541 agacggaaca gaataaaagt tgtggaaact caggttcatt tgtctgatat ttctgaggat 1044601 ttagccgtaa ggagctgaaa attattatta gggggtttgc gaatatgaaa aaacgttggt 1044661 cgattgtcac gttgatgctc attttcactc tcgtgctgag cgcgtgcggc tttggcggca 1044721 gcggatcaaa cggtgaaggg aaaaaggaca gtaaaggaaa gacgacactt aacattaata 1044781 ttaaaactga gccgttctcc ttacatccgg gattggcaaa tgattcagta tcaggcggtg 1044841 ttatccgtca gacttttgaa ggattgacac gtatcaatgc agatggtgag cctgaagaag 1044901 gcatggcttc taaaattgaa acgagcaagg acggaaagac atatacattt accattcgtg 1044961 atggtgtgaa atggtctaat ggagaccctg taactgcaca agattttgaa tatgcttgga 1045021 aatgggcgct tgaccctaat aatgaatcac aatacgctta ccagctctac tacataaaag 1045081 gtgctgaagc ggcgaatacc ggaaaaggca gcctagacga tgtggcagta aaagctgtga 1045141 atgacaaaac gctgaaggtt gaattaaata acccgactcc atatttcact gaattaactg 1045201 cgttctatac gtatatgccg atcaataaga aaattgcaga gaaaaataaa aagtggaata 1045261 caaatgccgg agatgattat gtatcaaacg ggccgttcaa aatgacggca tggaaacaca 1045321 gcggctctat tactctcgaa aaaaatgacc agtattggga taaagacaaa gtcaaactga 1045381 agaaaatcga tatggttatg atcaacaata acaatacgga actaaaaaaa ttccaagctg 1045441 gcgaacttga ttgggccggt atgccgctcg gacagcttcc gacagaatcc ctgccgaccc 1045501 tgaaaaaaga cggttcttta catgttgagc cgattgcagg agtgtattgg tacaaattca 1045561 acactgaagc taagccatta gacaacgtca atatccgtaa agctttaaca tattcgcttg 1045621 accgtcagtc gattgttaaa aacgttacgc aaggagagca aatcccggca atggctgcag 1045681 tgccgcctac aatgaaggga tttgaggata acaaagaagg atacttcaaa gacaatgatg 1045741 tcaaaacagc aaaagaatac cttgaaaaag gcctaaaaga aatgggctta agcaaggcat 1045801 ctgatttgcc aaaaatcaaa ttgtcttaca acactgatga cgcacacgcg aaaatcgctc 1045861 aagcagtaca agaaatgtgg aagaaaaatt taggcgttga tgttgagctt gataactcag 1045921 agtggaatgt ctatattgat aagctccaca gccaagatta tcaaatcggc cgtatgggct 1045981 ggctcggcga cttcaatgat cctatcaact tccttgaatt gttccgcgac aaaaacggag 1046041 gaaataacga tacaggctgg gaaaatccag aattcaaaaa gcttctgaat cagtcacaaa 1046101 ctgaaacaga taaaacaaaa cgtgcagagc tgctgaaaaa agcagaaggt attttcattg 1046161 atgaaatgcc ggttgcccca atctatttct atactgatac ttgggtacag gatgaaaacc 1046221 taaaaggtgt tatcatgcca ggtactggtg aggtttattt cagaaacgca tattttaaat 1046281 aaggctacgt ctgaaaataa aagacctcaa ggtatatggg gagaaaagcc ccatatacct 1046341 ttcttactga tggagtataa aaatgtaaaa accatggagg tgttccccct tgctaaaata 1046401 tatcggaaga cgcttagtct atatgattat cacactattt gtgattgtaa ctgtgacatt 1046461 cttcttaatg caagcagcac cgggcgggcc attttcaggt gagaaaaagc ttccgcctga 1046521 aattgaagca aatttaaatg cgcattatgg cttggacaag ccgctgtttg tacaatatgt 1046581 cagttatttg aaatcagttg caatgtggga tttcggaccg tcatttaaat ataaaggtca 1046641 gagtgttaac gacctgatca gttcaggttt ccccgtttca tttactcttg gagcagaagc 1046701 tattctcctc gctttagcgt taggtgtatt gtttggggtc attgcagccc tttaccataa 1046761 taagtggcag gattataccg tcgcgatttt aacgatattt ggtatttcgg ttccgagctt 1046821 tatcatggcg gctgttctgc aatatgtgtt ctccatgaag cttgggctgt ttccggtcgc 1046881 ggggtgggat tcctgggcat acaccttttt gccttccatc gcacttgctt ccatgccgat 1046941 ggcgtttatt gccagacttt cccgttcaag catgatcgaa gtgttaaaca gtgattatat 1047001 ccgcacagcg aaagcgaaag ggctttcccg cccagcggtt acagtgcggc acgccattcg 1047061 aaacgcactt ttgccggttg ttacatatat gggcccgatg gccgcacagg tcttaacggg 1047121 gagcttcatt attgaaacca tttttgggat tccggggctt ggtgcacact tcgtcaacag 1047181 tattacaaac cgtgattata cggtcattat gggtgtaacg gtgttcttca gtgtcatctt 1047241 gctattgtgt gtattaatcg tagatgtgtt atacggcatt attgatccaa gaatcaagct 1047301 ttccaaagca aagaaaggag cctaggccat gcagaacatt ccaaaaaaca tgtttgaacc 1047361 agccgcagcg aatgccggcg atgcagaaaa aataagtaaa aagagccttt ccctctggaa 1047421 agatgcgatg cttcgcttcc gcagcaataa gcttgcaatg gtcgggctta tcattatcgt 1047481 acttattatc cttatggcaa tttttgcgcc gatgttctca aggtatgatt attcaactac 1047541 taatctctta aatgcggata agccgccttc aaaagatcac tggttcggaa cagatgatct 1047601 tggacgggac attttcgtcc gtacatgggt aggggcgcga atctcaatct ttatcggtgt 1047661 tgcagctgct gttctcgatt tgctgatcgg cgtcatttgg gggagcattt caggcttccg 1047721 cggaggaaga acagatgaaa tcatgatgcg tatcgctgat atcctttggg cagttccttc 1047781 attattaatg gttatcttac tgatggttgt tcttccgaaa ggtctattta cgattattat 1047841 tgccatgacg attacaggct ggattaatat ggccagaatc gtgcgcggac aagtgctgca 1047901 gctgaagaat caggagtatg tgcttgcttc acagacactg ggtgcaaaaa catcccgtct 1047961 tctatttaaa catatcgtgc caaacgcaat gggttctatt ttggtcacga tgacactgac 1048021 agttcctact gcgattttta cagaagcctt tttaagctat ttgggacttg gtgttccggc 1048081 tccgctggca agctggggaa cgatggcttc tgacggattg cctgcattga cctattatcc 1048141 gtggcgttta ttcttccctg ccggatttat ctgcattaca atgtttggtt ttaacgttgt 1048201 cggcgacgga ttaagagacg cattggatcc taagttacgt aaataaggga gtgatacggg 1048261 tgacacgcct attagaagta aaagatttag caatttcatt taaaacatat ggcggagagg 1048321 tccaggcgat ccgcggagtg aatttccatc tggataaagg ggagacgctg gccattgttg 1048381 gagaatcagg ttccggaaaa agtgtaacct ctcaagcgat tatgaagctg attccaatgc 1048441 ctccgggtta tttcaaacgc ggtgagatcc tgtttgaagg aaaggatctg gtgccgctgt 1048501 ccgaaaaaga aatgcaaaat gtccggggaa aagagatcgg catgatattc caagatccga 1048561 tgacctcttt aaatccaacg atgaaggtcg gtaaacaaat tacggaagtg ctttttaaac 1048621 acgaaaagat ctcgaaggaa gcggctaaaa aacgcgcggt tgaactgctg gaattagtcg 1048681 gtatcccaat gccggaaaag cgggtgaacc aatttccgca tgaattttca ggcgggatga 1048741 gacagagggt tgtcattgcc atggcgcttg cagcgaatcc gaaacttctg atcgccgatg 1048801 agccgacaac tgctcttgat gtaacgattc aagcgcaaat tttggaatta atgaaggatt 1048861 tgcaaaagaa aattgacacg tccatcatct ttatcacaca cgatcttggt gttgtggcta 1048921 acgttgctga ccgggtcgct gtcatgtacg cgggacagat tgtagaaact ggtacggtag 1048981 acgaaatctt ctacgacccg agacatccgt acacttgggg gcttcttgca tccatgccga 1049041 cactggaaag ttcaggagag gaagagctga ctgcaattcc gggcacgccg cctgatttga 1049101 caaacccgcc aaaaggagat gcttttgccc tgcggagctc ttacgcgatg aaaatcgatt 1049161 ttgaacagga gccgccaatg tttaaggtat ccgatactca ttatgtaaaa tcgtggctgc 1049221 ttcatcctga cgcgccaaag gtagagccgc ctgaagcggt aaaagcgaaa atgcgtaaac 1049281 tggcaaacac gtttgaaaaa cctgtcttag tgagagaagt tgaatgaatt gactgaaaaa 1049341 ctattagaaa tcaaacattt aaaacagcac tttgtcacgc cgaggggaac ggttaaggct 1049401 gtagatgatt tatcatttga tatctataaa ggtgaaacat tagggctggt tggtgaatct 1049461 ggctgcggta aatcgacaac aggccgaagc attatcaggc tgtacgaagc aaccgatggt 1049521 gaggtgctgt tcaacggcga aaatgtgcac gggagaaaat cgcggaaaaa gctgctggaa 1049581 ttcaaccgca aaatgcagat gattttccaa gacccctatg catccctgaa tccgagaatg 1049641 acagttgctg atattattgc tgaaggcctt gatattcata agctggcaaa aacgaaaaaa 1049701 gagcggatgc agcgagttca tgaactattg gaaacagtgg gattgaacaa ggaacacgcg 1049761 aaccgctatc ctcatgaatt ttccggcggc cagcgccaaa gaatcgggat tgccagagcg 1049821 cttgctgttg atccggaatt cattatcgcg gatgagccga tttccgcttt ggatgtatcc 1049881 attcaagcgc aggtcgtgaa tttaatgaaa gaactgcaaa aagaaaaagg gctcacatac 1049941 ctgtttattg cccacgattt atcgatggtc aaatacatca gtgaccgcat tggcgtcatg 1050001 tatttcggga aactggttga gcttgcgccg gcagatgagc tttatgaaaa tccgcttcac 1050061 ccatatacaa aatcattgct ttctgcgatt ccgcttcctg atccggacta tgagagaaat 1050121 cgcgttcgcc agaaatatga tccgtctgtc catcaattaa aggatgggga aacgatggaa 1050181 ttccgtgaag tcaaaccggg acattttgtg atgtgcacgg aagccgaatt taaagctttt 1050241 tcatgattca tcaatccttc aagagatttc tcttgaagga tttttttgcg tcttcataga 1050301 aagtgagaat gataacattt acaattagag gaaaaagcgg aggcgaaata cgattcaatt 1050361 tctgcataac aaaaatgttt ttgcgctatt gctgtctcaa tcttttcaat ctttagcagg 1050421 agtcctcgtc acaatcgttt taatggtccg gatctatcaa atgactgact ccgttttttt 1050481 ggcgggcctt attttatcgt tcatgtcgtt tgcgagtata gcagcaagct tttgcgtctc 1050541 tccggtgctt cgcattctcg gttttaaaaa ggtgcttgcg ggagcgaatc tgctgagagc 1050601 ggtctttatt atactgatgg catacagcgt cactcatcac ggacaggcat tcttttggat 1050661 tacgctgctg tttgtgtttt gtttttcctt cgcgggcgct ttttttcagc cggcaagatt 1050721 tgcgctgctg ccgattattg ttccaaagaa gcaatatgta aaagcgaatg gtgtgatctc 1050781 cctctcgaat caattgttct taacagcagg ctggggcctt ggaggccttc tgacgtacgc 1050841 cgtccctttt gaactcgttg tcggcgctgc catttgcctg tttgttctat cgggagcttc 1050901 catcagtgtg ctgcatgtaa atgaagaaga ggctgcagga actgctgaaa cagcatctgt 1050961 cagaagtata tggaaggatt taatgatcat ccctattgta agagacatta ctgtaatgga 1051021 catgttagaa gctttggcgg gttccgtatg gtcatctgct attctcctcg catttactgc 1051081 ggctgttttg catgaaacag aggtgtggtg ggggatgttt aacgcttcct attttatagg 1051141 cgcaattgtc ggcagtgtga ttgctattcg tttttcttct ttttttgagc ggaatatggg 1051201 ctatgccatt atgttcagct cgcttgtaat gtcggcgctg acccttttgt tttcattttc 1051261 tccagtccca tttttatgcg ctctggcttg tgctgcaatg gggccttttt atcaggtgcg 1051321 tgatatttgc caggaaacca tgctgcagga agttattccc gagcagaaac gaatcggaat 1051381 catggctgca aaaaatgcga ttttgactcc ttggtcaggc gtcacctact ccattatggg 1051441 gctagtggct gatgctgctg gtgcgaaaat agcttttatc gcggctgctg cattatatat 1051501 catgacattt ctgattgcac tggcgcagcc ccgtctggtt cattacaggc gagaaaatcg 1051561 agttcaatga gaaacacttc aaaatgaacg gagcagctgg ctccgttttg ctgaaaaaaa 1051621 aatgaaacca tggcggaagt tcgcacgtct ttatagatgt aaggctgttt aaacaagaag 1051681 aaatggggta tatctaaaag tatgaagaca acgaactcat aaggagcaaa tcaatgaact 1051741 ggtatgaaaa gcttagcgag tactttccaa ttgaagaaat gaaatcaaaa gcgcatatgg 1051801 aagctcttct gaaagagcga agcgatattt atcataaaga tgaaggcaaa catcatattt 1051861 taatgtttgc ggaattcgat tcttttatct tcgttgatta tctgtatgtg tctaaggatg 1051921 caagagggca ggggcttggc ggcaaattga tcgcgaagct gaaaaagaaa aataagccca 1051981 tattgctcga ggtggaacct gtggatgaag atgatactga tacagaaaaa cgcctgaggt 1052041 tttatcaaag agagcatttc aagcatgctc agtcaattgg gtaccggcgc cggtcattgg 1052101 ctacgaatga agtaaacaag atggagattc tgtactggtc accaaaaaca gaatcagaag 1052161 aagaaattct tgaagccatg aaacagacat atgaaaacat tcatacttat aaagatgaga 1052221 aatggtacgg agaatcgtac gaaaaaacgg atgaggtctt ggaaatcatc gatgaagaaa 1052281 aacaaaaaaa tattttcgat cagttaagct aattgagaat aagaacatat catgaacatt 1052341 aaaaatttgc tggattgaca catttttttc ttaggatact gttcacactt acttttttat 1052401 agtataatac ctgtaaagat tcctttttta gagtaatttc aatttaagaa taaaatagat 1052461 gttcatccta ctaattagag gagtgaagat gaatggttac actatacaca tcaccaagct 1052521 gtacttcatg cagaaaggcg agagcgtggc tcgaggagca cgagattcca tttgtagaaa 1052581 gaaacatttt ctctgaacct ttatcaattg atgaaataaa acaaattctt cgaatgactg 1052641 aggacggaac agatgaaatc atctcaaccc gttcaaaagt attccaaaaa ctgaatgtga 1052701 acgttgaatc tatgccgctg caagatttgt accgcttgat caacgagcat ccaggtttgc 1052761 ttcgccgtcc gatcatcatt gacgaaaaac gtttgcaggt cggatataac gaagacgaaa 1052821 tcagacgttt cctgccaaga aaagttcgct ctttccaatt aagagaagca cagcgtttgg 1052881 caaactaata gatcgtatca tcaaaagaag gctgagtcat cagccttctt ttatttttca 1052941 acctgctggt aataaatgct cgcaaggatg acaaacgcaa ccgtcaaaat ggggaggagc 1053001 gtttcgactg tgccgtgctg cgccataaaa agcgacagct ttttgtctct gacaatcatt 1053061 tctccgccag tataagcaag cagcccgctt cccgcgtaaa tcagaagcgg tattttctct 1053121 agtgcaatat ggatgagttt gctgccccaa ataataaccg gaaccgatac acacaatcct 1053181 ataacaacga gagaaaactc accgtgtgaa gctcccgcaa ctgcgatgac gttgtccagc 1053241 gacataaaga gatctgcaag cacaatcgtt cgtatcgctc tccacaggga ggtgctgctt 1053301 ttaatgtgtt tcgtgtcttt tttttcaatc agcagctgat atcctaaata cagcaggaaa 1053361 attccgccgg cgcactgcaa gaacggaatg ttcaaaagat atactgctgc acttgttaat 1053421 ccgattctca tggcaacggc aataaatgtt ccgagaataa tggcttgctg tctttgcttg 1053481 tccggcaaat gtctgctggc catggcaata acaaccgcgt tatctccgcc gaggatcagg 1053541 tcaatcccaa caatgacgag cagagaaatc agatagtcat gctccatgaa gcggcacctc 1053601 gctttcagtc cttcgcttgt actactacta tatgagacag gtcatatttt atgatatcag 1053661 ccgcctgatc tgccgttttt taggcaaagg tgcattttta tttcttttgt gactgtttta 1053721 tcataaaata gaaatacaaa ggaattcaca ctggccttgg ttaaggttaa gatgtggacg 1053781 gaatgggtaa agtgtagtaa agtacaatta atcgggagct tagatgtccc ttcaacatct 1053841 tatatagaag ggaaggttgg caaatggaaa ttgaaagaat taacgagcat acagtaaaat 1053901 tttatatgtc ttacggagat attgaagatc gcggttttga cagagaagaa atttggtata 1053961 accgtgagcg cagtgaagaa cttttctggg aagtcatgga tgaagttcat gaagaagagg 1054021 aattcgctgt ggaaggccca ctttggattc aagttcaggc actggacaaa ggattagaaa 1054081 tcatcgtcac aaaagcccag ctttccaaag acggacaaaa gctcgaactg ccgattcctg 1054141 aggataaaaa gcaagaacca gcatctgagg atcttgacgc cttgctggat gatttccaga 1054201 aagaagagca agccgtcaat caggaagaga aggagcaaaa gcttcaattt gtcttgcgat 1054261 ttggcgattt tgaggatgtt atttctctat ctaaattgaa cgttaacgga agcaaaacga 1054321 ctttatattc gtttgagaac cgatattatt tatatgtaga tttttgcaat atgactgatg 1054381 aagaggttga aaatcagcta agcatcctgc tggagtacgc aactgaatcc tcaatcagca 1054441 tacaccgtct tgaagagtac ggcaagctga ttatttcaga gcatgctcta gaaacgataa 1054501 aaaaacactt tgcatcatag caaaccgatt tccttccgga aatcggtttt ttttatgcac 1054561 gaaaatgcca ttttagagat gtgaaaaatc aaaaacatat agacaagcag aaaatacagc 1054621 gaacaggagt tgatcatctt ttccagaaag tatacttcat ctggaaagga gagatgacaa 1054681 ttgtttagtg ctgtgactga agacggccaa atgtttcacc ttctaggcgc tcagcaaaac 1054741 cagaaattaa agcggagacg gttcttctgt ccggtatgcg ggggagagct agctgtgaag 1054801 ctcggacttc aaaaagcgcc gcattttgcc cataaacaga acaagtcctg cgccatagac 1054861 atcgagccgg aaagcgccta ccacttagaa ggaaaaagac agctgtatgt atggctgaaa 1054921 acgcaacggg cttcaccaat attggagccg tatataagga caatcaacca aagaccggac 1054981 gtcatggcaa gaatcaagga gcatatgctt gctgttgaat atcaatgcgc cactatcgct 1055041 ccagatgtct ttcaaaagcg gacagagggc ttcaaacaag aaggaatcat cccgcagtgg 1055101 attatgggat acagccgctt aaaacggact gcttcgtcct tttatcagct ttcaactttt 1055161 cattggcagt ttatcaatgc aagtccatac agagaactga tatgttattg tcctgaaagg 1055221 cgttcttttc tccggctcag ccacatcatt ccattctaca caaaccattc ttattcctca 1055281 gtccaaacga tccctatcca tcgggcaggt gcaggcgatc tttttttcac tgaaccgaaa 1055341 ccctcaattc aatattcagg ctggacgaaa gcgattcacc gttttcgcca taaaccccat 1055401 cggtttaact caaaggaaac aaatcgcctt aggctgctgt tttatgagaa acgacagacg 1055461 cctttttctt ttctgccgac tgaagtgttt gttcctgtta gaaaaggggc agtttttaag 1055521 agtccggttt ttgtgtggca ggggtttctt tatttgttta tgacggatct tggaggtaaa 1055581 cgtgcgccaa ttcgtttttc agccgttttg cagcagtgca aactgcacat tcataataag 1055641 aacattgcac tcaggtccga atgcagcgaa gagtgtcttt cagaagcggt taaacagtat 1055701 attgattttt tgtgcaagaa gggattttta agggagactc agaaagaagt atatgtgctg 1055761 aatcagcctg caggaggcat acactccatg caggatctca tagaaagaga ccgcagctgt 1055821 tttatagaat gagtttgtct tatttggctc accctaagac aaaggtggtg ggcaggctgt 1055881 gaaaggcaca aaaggaaagg tttttcgtgt ttttactgct tttttggcat tcgttctctt 1055941 cattactgca tatgatttga caaaaggcag tgaaaaaccg gaagatattc acaacacaag 1056001 tttattgaga aacagctgtt ttttcaattg gcttgaatca aagaagacga gggggatcac 1056061 catggctgag gaaaaaaaag caaaccaact gcctgacaga agtgaggtaa aggcagaaga 1056121 cacatggaga cttgaggata tttttcctag tgatgaggcc tggaataaag aatttcaagc 1056181 tgtaaaagaa ttaattccga atttatctaa gtataaagga aagctggcag attcagctga 1056241 tcatttatac gaggctctta cgtatcaaga taaagtgatg gagcggctag gtaggctgta 1056301 cacatatgcg catatgcgct ctgaccagga tactgggaac tccttttacc aggggctgaa 1056361 tgacaaggcg ggaaacctgt atacacaggc cgcaagcgcg acagcttatt tggttccgga 1056421 gattttatcc atagaagaag acaaactgca gcagttcatt cttgaaaaag aagaattgaa 1056481 gctgtactct catgcgattg aggagattac aaaggaacgt ccgcatgtgc tgagcgagaa 1056541 ggaagaggcg ctgcttgctg aagcctccga ggtactgggg tcatcttcaa atacattcag 1056601 cgtgttaaat aacgcagata taacgtttcc atccattaaa gacgaagatg ggaatgaaaa 1056661 acagatcact cacggcaact ttattaattt cttggaaagt gaaaaccgtg aagtccgcaa 1056721 aaatgcgttt gacgcagtgt ataaaacgta cggacaatat aaaaacacaa tggccacgac 1056781 gctaagcggc actgtgaaaa aggacaactt ctacgcgaga gtgaaaaagt acaagtccgc 1056841 gcgtgaggct gcgctttcta acaacagtat tcctgaggaa gtatacgata accttgttaa 1056901 gacgattaat aagcatttgc cgctcctgca ccgctatatt gcgctaagaa agaaagtgct 1056961 tgagcttgat gaagtgcata tctatgacct gtatacaccg cttgtgaaag atgctgggat 1057021 gaaggtgaca tacgaggaag ccaaagatta catgctgaaa ggcctcgcac ctttagggga 1057081 agaatatgcc tctatcctaa aagaaggact ggaaaaccgc tgggtggacg tttacgaaaa 1057141 taaaggcaaa cgcaatgggg cttattcatc aggagcttac ggcacgaatc cgtatatttt 1057201 gatgaactgg cataataacg tcaataatct ctttacgctc gtgcacgagt ttggacattc 1057261 cgtacacagc tactatacga gaaagcacca gccttatcca tacggcaatt acagcatctt 1057321 tgtcgcggaa gttgcctcta cgacaaatga agcgctcctt ggcgaatatt tgctgaacaa 1057381 tttagaggat gaaaaacagc gcttatatat tctcaaccat atgcttgagg gcttcagggg 1057441 aacggtcttc agacaaacga tgttcgctga atttgaacat ctgattcata caaaggcgca 1057501 agaaggcgag ccgcttacac ctgagcttct gacaaatgtc tattacgacc tgaataaaaa 1057561 gtattttgga gacggcatgg tgattgataa ggaaatcggc cttgaatggt cgcgtattcc 1057621 gcacttctat tacaattact atgtgtatca gtatgcgaca ggttacagcg ctgcccaagc 1057681 attaagcagc cagattttga aggaaggaaa gccggcggtt gaccgttata ttgacttcct 1057741 gaaagcggga agctcacaat acccgattga tgtcctgaaa aaagcgggtg ttgatatgac 1057801 gtctccagag ccaatcgaag ccgcgtgcaa aatgtttgaa gaaaaacttg atgaaatgga 1057861 agagctgctg atgaaagtca agcagtctta aaaaagtaag cctgtgcgga aatgacgcac 1057921 aggctttttt aaaacccttt aaaggttttc cggtgattca agcggtagag ggtaaacaaa 1057981 atagacagaa acagcagagg agaggtaata taaagcggca gcatatgcat catgcctaag 1058041 atattcaagc agaaaaaaac agcaatgcac acaattgaga tcaaagtaga catcatggcg 1058101 gtcctcctcg tcctttttcc ttataaggat atgagtgaat gcacttcgtt atgttttgtg 1058161 acaaaaatat gaacattaag catagaggtt gtcaaaagtc gacatctttt gttatcataa 1058221 ggatgtgaaa ttgatcacaa acaaacatta cccctttgtt tgaccgtgaa aaatttctcc 1058281 catccccttt gttgtcgtta agacatatga aaccgcgctt atcccggcgc ggtttcttta 1058341 gtgctaaaaa tggaacgtac gtttggttat ggcataaaaa aacagcctca agcatatgca 1058401 cgcctgcggc tatttttcac atgattgata ttcatcagaa taagtgctga gagacttcca 1058461 aaacattccg tgtttggctt ccactttggc aaccttttta gcaaacgcca gttttttcat 1058521 ttctttttct acctcttcaa ggctcaggtc atatacaaga gcaatttcct tcgaggcaac 1058581 gaagcggaaa tattcaataa aacattctaa aggcggtgtt tccgacggct tcggctcgtc 1058641 gccaagcatc tcaaataaaa tttcttcata tacatcatat gagtagctgc caggaacttt 1058701 aagcccttca tcctcatgct gcgtattaaa aaacgtcagt gtcggattaa cagaaacatc 1058761 catctcggca gcaattttca tgtcacattg aagcgccttg accgcgcttt gagaatgcag 1058821 atcttttttg aattcttcaa gatcgagact tgtattttca gcaatctcca aaagcacgtt 1058881 ttcatccgta atatttttct ttgaaacaaa taggctctcc tgcatatttc tgagaaattg 1058941 catgccggct tttcgtcctt gcagttcggc tgctttaaaa gcgagagcag ccatataagg 1059001 cgatgaaagc ggctgatcct gttcgaacca gacattgccg tcacatgaca tgccagagcg 1059061 gctcgcgatc ttttcccatg cttctgcgag aagatgcttt tttcgctttt tatttaaagc 1059121 ggtaaggctt gcggaagcga taatgcgtaa ggtgaaaaaa cgtccgtatc tgattttcag 1059181 ctttttgatg acgggctcta aggaccagca ttcaggacat aaagggtcta caaacatata 1059241 aatttcaagc ggtttttttg gatgaccgtg gcaatgggcg aagtatagct catgctgata 1059301 gtttgtcaag atgatcgatc ctccgcttcc gtttgattca ccatatgcct tgctgtcaac 1059361 tccagccggc caaacaaaaa ctcacgaatt tcgccctcca gccctacatg gtccattgcg 1059421 tccttcatac agctgagcca cgcatcagct ctctcgtttg taattggaaa gggaagatgc 1059481 cttgctctga gcataggatg gccgtgttcc tcagtataaa gaggaggccc gcctaaatac 1059541 tgagttaaga attgcttctg tttcctggcg gtttctgtca aatcgcttgg aaaaatcggc 1059601 ttcagcaaag gatgagacgc gacacgctca taaaaagtat caacaagttg cgatagaagt 1059661 tcctctccaa tcgcttcata aggtgcgtta aacgattgtc ccatgttgac tactccttta 1059721 aatatggcta ataggaatca taaatcctat tgcaaaaagt aattttctgt atttcattgt 1059781 ttcatctaga tttattttag caacaaggca tcatttctac aaacaaactg ccttttatgc 1059841 gtttgatgac tcatttcggc tgacagccgg ggtttgtatt tcatatcata tcacataaaa 1059901 atcaggaatg cgtaagattt cacttcgcaa aaaaaccaga gggaaagagc acctctggtt 1059961 acgcgtaata aactgaagtt atttttttta catagttttg cgtttcttgg aaaggaggaa 1060021 tgcctccgta tcggtcaaca ttccccggtc cggcgttgta agccgctaat gccatagaca 1060081 cattgccgtc gtatttatcc agcatttgtt ttaaatattt cgttccgccc tccacatttt 1060141 gctgcggatc aagcggattg gaaacgccaa gtgagcttgc tgttgacggc atcagctgca 1060201 tgaggcccat cgcacctgct ccgctgaccg cttttgcatt aaagcctgat tcctgtttga 1060261 tgacggcgcg gatcagtttt tcatcaacgc catatttatc agcggctttt ttaatcgcac 1060321 tgtcaataga gaagtctccc gaacggatct gatttgcttc atgtttgttt gaagctgaat 1060381 ctgcaacagc tgtttcagtg ctttctgccg cttttgtgac tgaacctgaa ttgctgctcg 1060441 tatatgagtt aagcccatac gctgaaagca gtgacggcgc tgttgtattc gcgctgttca 1060501 gcatgctgag cgggcttggc gatgaagaag gtgctgattg ctgagatgtc agaccgtttg 1060561 tatattggct gagcaaagaa ctgaaacttg aaagcgggct ttccgtattc tgagtgtccg 1060621 agctgctgcg tgcattagat atggactgta atgcctgaag ctgaagtaat gctgcccaat 1060681 tcgttacatt cacgatgtca ttccacctta tatagacttt cgtttttctt cataaaaacg 1060741 cagaatttta tttttggttt cgcgctgagg aatgctgaat tgctgaagca gcttttcgaa 1060801 ggcttgtctg ccctcatgcc aatccgccgc ctcaaattca atttcatagt cctctttatt 1060861 taaatatcgg ctgtggtcta aaactattaa gcctttttct gtttcttttt ccgcacggtt 1060921 tgttgctaaa gatccaaagt attgtatggc atccgtatcg atctgaagct tgtgcagctg 1060981 gtccttcaca gggccctcgg gaactgaaaa tccagcgaga tctgatacct ctgaaagctg 1061041 ctggtgcgtt tccagaagcc ccacatcagc cggctccttt aatgtaagga catactttcc 1061101 gttttttctg cggatacgaa gcgcagcatg tttttgtttc agcgcgaagc tgtctgtatc 1061161 aaaataatga ttcttttgat ctgtaaaatc tttttctgtc agctggagtg ccgatgctat 1061221 gtttttgaat tcttgtttgg tcagcatgtt tttaaattcg atttcaatct cttggctcat 1061281 gatgctcttc ctttccgccc tgtaaatctt atttttacta ttatctcttt agatgttagg 1061341 tttatcaata tcgagctcga tatgataaaa tgaatctgta ctttgtttaa aaaaggagag 1061401 cattatgcaa aacagaatcg aaattttgaa tgcaacatta tcggatgatc agcttcgcct 1061461 tgcctgtcag acagaaggaa acgaagcgga acgcaagccg tcaggtcaaa tgcttgttga 1061521 ttctgaccac tttgcttttg tatacatact tgaattagct gattcttttg aatatgtcat 1061581 tataaaggaa catgtatggc cggaactgaa gcaggcccat gcacaaaaaa taccggttgt 1061641 tttagaggca ggagaccaaa caattgaact ggcaggcctg catgaggagc tggaatatct 1061701 tttagaaaat ataaaagata atgcaaacta tggagaagaa atggaagaaa aagtgaaacg 1061761 cgtgttttta tagaaactgg ttcggaattg ggggatgtat gatggatgac aaacaatggg 1061821 agcgtttttt agtgccgtac cgccaggctg tcgaagagtt gaaagtgaag ctcaagggga 1061881 tccgcacact atatgaatac gaggacgacc attcaccgat cgaatttgtg accggacgcg 1061941 tcaagcctgt ggcgagcata cttgaaaaag cgagacggaa aagcataccg ctgcatgaaa 1062001 ttgaaaccat gcaggacatt gctggcctta gaatcatgtg ccaatttgtc gatgacatcc 1062061 aaatcgtaaa agagatgctt tttgccagaa aagatttcac cgttgtggat cagagggatt 1062121 atattgcgga acataaagag agcggatacc gatcatacca tcttgttgtg ctgtaccctt 1062181 tgcagacggt atccggagaa aagcatgttc tcgtagaaat acagatccgt acactggcga 1062241 tgaatttttg ggcgaccatt gaacattcat tgaattataa atacagcgga aacattcctg 1062301 aaaaagtaaa actaaggctt cagcgcgctt ctgaagcggc ttcccggctt gatgaagaga 1062361 tgtcggagat caggggtgaa gtacaggaag ctcaagctgc cttttcaaga aagaaaaaag 1062421 gaagcgagca acaataggta aaggggaaga agagcatgaa atttgccgta tcatcaaaag 1062481 gagatcaagt ttctgatacg ctgaaaagca aaatacaggc gtatttattg gattttgata 1062541 tggaactgga tgaaaatgaa ccggaaatcg ttatttcagt cggaggcgac ggaacgcttt 1062601 tgtatgcttt tcacagatac agcgaccgtt tggacaaaac agcatttgtc ggcgttcaca 1062661 caggtcatct gggtttttat gccgactggg ttcctcatga aattgaaaaa cttgttcttg 1062721 ccatcgcgaa aacgccgtat catacagtcg aatatccgct tctcgaagtc attgtgacct 1062781 atcacgaaaa cgagcgggaa gaaagatact tagctttgaa tgaatgtacg attaaaagca 1062841 tcgaaggaag ccttgttgct gatgtggaaa tcaaagggca gctctttgaa accttccggg 1062901 gcgacggcct ctgcctgtca actccatcag gcagcacagc ctacaataag gcgctgggcg 1062961 gagcgattat ccatccgtct atcagggcga tccagcttgc ggaaatggct tcaattaata 1063021 accgcgtgtt ccgtacggtc gggtcacctc tgcttctccc atcccatcat gattgcatga 1063081 ttaagccgag aaacgaagtt gactttcaag tgacgattga ccatttaacc cttctccata 1063141 aggatgtaaa gtcgatccgc tgccaagttg catccgaaaa agtgcggttt gcgagattcc 1063201 gtccgtttcc attttggaaa agagtccagg attcgtttat tggaaaaggt gaatagaaag 1063261 aggacatatc gtggagcatt tttttatcag aaagaacatt acttccgctg aggacgggat 1063321 gactgtaaaa gaatatgccg gtgaactggg aatttcgaaa cgtctgctga ccgatattaa 1063381 gtttggcggg ggagacctgc agattaacgg tgagcatgtg acggtcaaat acgttttgaa 1063441 agagggagat cttcttatcg tgaagtttcc tgaggagcag gtgagcgaga cgctgttggc 1063501 agagcctgtt ccgctcgata tcctttatga ggatgaacat gtgcttgtga taaacaagca 1063561 gccgtatgtg tcatcaatcc cttcgagaga gcacccctcc ggcagcattg ccaatggaat 1063621 tattgatcat tatcaaacaa ccggagtgag ggcgacagtt catcttgtca cccggttaga 1063681 ccgggataca tcaggtatca tgcttgttgc caagcatcga tttgcccact ccattttatc 1063741 gtctgcgcaa aaaaacggcc ttgtgaaacg ccggtatgcg gcagtggttc acgggcggat 1063801 ggcacagatg gagggaacag tcgatgctcc gattggcaga catcctgaca gtattattga 1063861 acggacggta acgccagacg gccagaaggc tgttactcat ttttacgtca catgtgcaaa 1063921 tgatgacatg acctcggtgg cattgcagct tgagactgga cgaacccatc aaattcgtgt 1063981 tcatatgagc tatctcgggc acccgttgtg cggcgataca ctgtacggcg gaacgagaca 1064041 ggaaattggc cggcaggctc tgcacagcga gcatctttcg tttatccatc cgctgacaca 1064101 ggagaacatg aggtttcatg ctccactgcc tcaggacatg agcaaactga taaaaggaga 1064161 gaatcattga ttctctcctt ttttatatgg ggcgaaatct tgattcgtcg taaggcaggg 1064221 agcttggaac agagacggtt tctatttctg gaaagcgaaa gcctgtcagt tgatttccga 1064281 acacgcagcc tgtatcaatg ttgatggtgc gattgacctt ccgaggctct ttcacaggtg 1064341 tatgaccgta taccacccaa gcctttccgt tataggctgc cgcccaatca cgcctgatgg 1064401 gtctgccgtc cggatatgtt tcacccgtca cgtcaccgta aagcacaaag tccttcactc 1064461 tgcgggtata tttgccgata tcgtcagctc ttatgccagc atgggcgaca actaattctc 1064521 cattatgtaa gatgtcgtaa agcggcgctg tttcgtacag cttcataaac tgttcgctga 1064581 ctgatttttt ctcatctttg gaaagttcct caagctctgc cgctgttgtt tcgagaccat 1064641 gcatcacttt taccggattt ccttttaagt aacgatataa tttattgcaa tggtttcccg 1064701 ggacataacg cacagcgcct ttttcgtaag cgccggctac aaatcggatg acctctatcg 1064761 atttgggccc tctgtcagtt aaatctccgg caaaaacaag caccctgcct tcttcatgga 1064821 caggtactcc atttttgatt gtatagccaa gcttttggat taatgcagtc atttcgtcat 1064881 agcagccatg aatatcgctg atgatatcgt aagccatgcg gtctcctcct taccgattgt 1064941 tttatttatt atgaagcaaa gtgttgtgag tcatcacaag cttttatgtg caaattatag 1065001 aagaagaatc attttctaaa caggattaag accttatcac tttatttttc atcatcaccc 1065061 ttgttaaaat cgcgttatgt tttttaaaaa tgaggttttg ttctctgagt gagaactagc 1065121 ataaccctga cttaaaaagg aggttctgat tatggcgcat acatctgtcg catctttagt 1065181 tgttgtactt atcgttgcat ttttgacacc catccttttg catcggttta aactcagcat 1065241 cccggttgtt gttgctgaaa tcattatggg gctgataatt gggaaaagcg gccttaattt 1065301 agttgtggag ggtgacacct ggctccagac actctctatg ctcggattta tctttttaat 1065361 gtttttaagc gggcttgaaa ttgatttttc gtcgtttgag aaaggaaaga aaaagcagtt 1065421 cctgccgaat ggcaaggaag cgccgaatac gtttgctgcg gcatctgtta ttttcgtcgg 1065481 tatttttatt ttatcattgc tcttgtccta tgggttcgtc ttggccggat ttatccaaaa 1065541 tgcatttttg atgaccctga ttatttcaac gatttcatta ggcgttgtcg ttccaacatt 1065601 aaaagaagaa cggatcatga attcgaatat cgggcagatt attttgcttg ttgctgttat 1065661 tgctgatttg gccacgatga ttcttcttgc tgttttttct tctttatacg gagaggacag 1065721 cggaaacatg tggctcctga tgattctgtt tgcggccgga gtggtgcttt actttttcgg 1065781 ccgggtcttc aaacatcgct cttttgttca atccatgtca aaagggacga tccagatcgg 1065841 gacgcgtgcc atttttacgt taatcattgt actcgttgcc ctgtctgaat cacttggggc 1065901 ggaaaatatt ctcggcgctt tcttagcggg ggttcttgtt tccctgcttt cgccaaacaa 1065961 agaacttgtt cagcagctgg actcattcgg ttatgggttc ttaataccga ttttcttcgt 1066021 gatggtcggt gtgaagcttg atatttggac tcttttccag gataaaacaa ttttaatcat 1066081 gattccgctc ctgctgcttg cgctgttagt cagcaaaatc attcctgtca tgtacttaaa 1066141 gaagtggtat gataaccgaa ccattttcgc gtctggtttc ctgctgacat caacgctttc 1066201 gctcgtgatt gctgctgcaa caatcggcca gcagcttcac gtgatcagta caaatatgtc 1066261 aggagcgcta attttagtag ccgtcattgc aagtattttt acgccgatct gttttaaaaa 1066321 attatacaaa cgggaagagc agccggagga gaaaaagacg attacgttca ttggcgccaa 1066381 tcaaatgact ttgcctgtca cactcgaatt gccagaggaa gagtatgacg tgcgtgttgt 1066441 acacgtctac caagagaatg cggaggaaaa gctgtcagaa tcagtgtttg ctgttgaaac 1066501 aatttctgac tatgaacacg agacgcttga atcactcggc atttttgaaa cggatatcct 1066561 cgttgtggcg acaggaaatg aagatatgaa tgcagacatt gcattacttg caaaagataa 1066621 aggcacagaa agagtcattg caagcgtagg atcaccggag catgaagcag ctctgaagga 1066681 gcagggaatc agcatctttt ctattctgct gtcgacaaaa acgctgcttc gcgcactgat 1066741 tgaagcgcct ggcgtcatga agctgctcac gaaccaagag tcttcgctgt atcaaattaa 1066801 tatggagaac agtaaatatg atggtgtcat tttacgggaa ttccctttaa caggtgacgt 1066861 catctttgtc aggatcttca gaggtgtgga cagcatcgtt cctcatgggg atacgaggct 1066921 gaaacttgga gaccgtttaa ttgtcaccgg atctcggggg tacgtaacgg atcttaagaa 1066981 aacattggaa ggataaatct tgaccaaata aggattcgtg ttaatataga ggtgcagaac 1067041 aattcaatat gtattcgttt aaccactagg ggtgtccttc ataagggctg agataaaagt 1067101 gtgactttta gaccctcata acttgaacag gttcagacct gcgtagggaa gtggagcggt 1067161 atttgtgtta ttttactatg ccaattccaa accacttttc cttgcgggaa agtggttttt 1067221 ttattttcag agggggaatg atttgtgaag ttttcagaag aatgccgcag tgcagccgca 1067281 gaatggtggg aggggagctt tgtccatccg ttcgttcaag gaatcggtga cggaacgctt 1067341 ccgattgacc gttttaaata ctacgtactt caggattcct attatttaac gcattttgca 1067401 aaggtgcagt catttggtgc cgcttatgcg aaggatcttt atacaacggg gcggatggca 1067461 agccatgccc aaggtacata tgaggcggaa atggcgcttc atcgcgagtt tgccgagctg 1067521 ttggaaatca gcgaggaaga gcgtaaggcg tttaagccgt ctcctacggc gtactcttat 1067581 acatcccata tgtaccgttc ggttttgagc gggaatttcg cagaaatctt agcggccctg 1067641 ctgccatgct attggctcta ttacgaggtt ggtgagaaat tgctgcattg tgatccgggg 1067701 catccaattt atcagaagtg gattggcaca tatggcggtg attggtttag acaacaggtc 1067761 gaggagcaaa tcaaccgctt tgatgagctg gcggaaaaca gcacggagga agtgcgtgcc 1067821 aagatgaaag agaattttgt catctccagc tactatgaat atcaattttg gggaatggcc 1067881 tatcgaaaag aaggctggtc tgacagcgcc ataaaagagg tggaggaatg tggagcttca 1067941 cgccataacg gatgacagca agccggtaga agagctagcg agaatcatca ttacgattca 1068001 gaatgaagtt gattttattc acattcggga acgctcaaaa tcggcggcgg atattttgaa 1068061 actgctcgat cttatttttg aaggcggtat agataaacga aaattggtga tgaacgggcg 1068121 cgtggatatt gcacttttct ctactattca ccgcgtgcag ctgccaagcg gcagcttttc 1068181 accgaagcag atcagagcca gatttccaca ccttcatatc gggaggtcgg tgcattcact 1068241 ggaggaagcg gttcaagcag aaaaggaaga cgcggactac gtgctgttcg gccatgtgtt 1068301 tgaaacggat tgcaaaaagg gtcttgaagg cagaggagta tctttgctgt cagatatcaa 1068361 acagcggatt tccatcccgg ttatagccat cggggggatg acgccggaca ggttaagaga 1068421 cgtaaaacaa gcaggggcag acggcattgc tgttatgtca ggaattttct cttccgctga 1068481 acctttggaa gcagccagac gatattcccg caagctaaag gagatgcgct atgaaaaggc 1068541 attatgaagc agtggtgatt ggaggcggaa ttatcggttc cgcaattgct tattatttgg 1068601 caaaggaaaa caaaaacacc gcattgtttg aaagcggaac aatgggcggc agaacgacaa 1068661 gtgccgctgc cggaatgctg ggcgcccatg ccgaatgcga ggaacgtgac gcgttttttg 1068721 atttcgctat gcacagtcag cgtctgtaca aaggtcttgg agaagagctt tatgcattat 1068781 ccggtgtgga tatcaggcag cataacggcg gtatgtttaa gcttgcattt tctgaagaag 1068841 atgtgctgca gctgagacag atggacgatt tggactctgt cagctggtat tcaaaagaag 1068901 aggtgttaga aaaagagccg tatgcgtctg gtgacatctt tggtgcatct tttattcagg 1068961 atgatgtgca tgtggagcct tattttgttt gcaaggcata tgtgaaagca gcaaaaatgc 1069021 ttggggcgga gatttttgag catacgcccg tcctgcatgt cgaacgtgac ggtgaagccc 1069081 tgttcatcaa gacccctagc ggagacgtat gggctaatca tgttgtcgtt gccagcgggg 1069141 tgtggagcgg aatgtttttt aaacagcttg gactgaacaa tgcttttctc cctgtaaaag 1069201 gggagtgcct gtccgtttgg aatgatgata tcccgctgac aaaaacgctt taccatgatc 1069261 actgctatat cgtaccgaga aaaagcggaa gactggttgt cggcgcgaca atgaagccgg 1069321 gggactggag tgaaacaccg gatcttggcg gattggaatc tgttatgaaa aaagcaaaaa 1069381 cgatgctgcc ggctatacag aatatgaagg tggatcgttt ttgggcggga ctccgtccgg 1069441 gaacaaagga tggaaaaccg tacatcggca gacatcctga ggacagccgt attttatttg 1069501 cggctggcca tttcagaaac gggatcctgc ttgctcccgc aacgggcgct ttgatcagtg 1069561 atctcatcat gaataaagag gtcaaccaag actggctgca cgcattccga attgatcgca 1069621 aggaggcggt tcagatatga tgctacagct gaacggtaaa gacgtgaagt ggaaaaaaga 1069681 cacaggtaca attcaagacc tgctggcgtc gtatcagctt gaaaataaaa tcgttatcgt 1069741 ggaaagaaat aaagaaataa tcgggaaaga acgctatcac gaggttgagc tttgtgatcg 1069801 tgatgtcatt gaaattgtcc attttgtagg aggcggatga gcatgttaac aattggcgga 1069861 aaatcatttc aatcaagatt gctgctgggc acggggaaat acccatcgtt tgacattcaa 1069921 aaggaagcag tagctgtttc tgagtctgat attttaacat ttgctgtaag gagaatgaac 1069981 atttttgaag catctcagcc gaattttctg gaacagcttg atttatccaa atatacgctt 1070041 ttgccgaata cagcgggcgc cagtactgct gaagaagcgg ttcggattgc aaggctggcg 1070101 aaagcttcag gcctttgtga catgattaaa gttgaagtca tcggatgcag ccgttccttg 1070161 ctgcctgacc ctgttgagac attaaaagcg tctgaacagc ttcttgaaga aggctttatt 1070221 gtgctcccgt acacgtcgga tgacgttgtg ctggcgagaa agctggaaga gctcggcgtt 1070281 catgccatca tgccgggtgc atctccgatt ggatcaggac aaggaatctt aaatcctttg 1070341 aatctgtcgt ttattattga acaggcgaaa gtaccggtca tcgtggatgc gggaatcggc 1070401 tcgcctaaag atgcggcata cgcaatggag cttggagcgg atggcgtact gctcaatacg 1070461 gctgtatctg gcgctgacga tcccgtgaaa atggctcgtg ccatgaagct cgcagtggaa 1070521 gcagggcgcc tttcttatga ggcgggccga atcccgctta agcaatacgg aacggcaagc 1070581 agtccgggag aaggtcttcc tgtatgacag gcaggtattc aaggcaggag ctgtttgctc 1070641 cgatcggccc atccggccag aaaaaattga aagaagcgcg cgccgtgatt atcggcgccg 1070701 gcgcgctcgg aacagccagt gcagaaatgc tggtgagagc gggagtcggc tctgtgaaaa 1070761 ttgccgacag agattatgtt gaatggagca acctccagcg ccagcagctt tatacagaag 1070821 atgatgtcaa aaaagaaatg ccgaaagcag ccgctgcgga gcgccgtctc cgttcgatta 1070881 acagcgatgt tgatgtgacc ggccttgtca tggatgtgac agcagaaaat atcttcgagc 1070941 tgattaggga tgcatcgatt attgtggatg cggctgataa ttttgaaacc cgcctgatcg 1071001 taaatgatgc tgcggtaaag gaagggattc cttttcttta cggtgcctgt gtagggagct 1071061 acggtcttac ctttaccgtg gtgccgggtt ctactccttg cctgcattgc ttgctcgatg 1071121 cacttccgat tggcggagca acatgtgaca cagctggcat catcagtccg gctgttttgc 1071181 aggtagcagt ctttcaggta acagatgcac tgaaactgct gacgggagag gagtgcgagc 1071241 cggtgctgcg ctcctttgat ttgtggaaaa acgagcggtc agaagtgaga gcggccagtc 1071301 tcaaacatga cgcatgccca agctgcggca caaaggattt tccgtttttg tcttatgaaa 1071361 atcaaacaaa agcggctgta ttgtgcggca ggaacacggt gcagatcaga tcatctatta 1071421 cgaaagaagc ggatcttgaa gcgcttgccg gtcagctgag gcaggccggg cttgaagtag 1071481 ctgcgaaccc gtatttaatt tcctgccgct cggatgatat gaaaatggtg ctgttccggg 1071541 acggcagagc tttgatccat ggaacaaatg atattgcccg ggcaaaatcc atttatcata 1071601 aatggattgg gtaataaaag gagtgtagtg taatgagtat atataaagca ttgacaatcg 1071661 ccggatcaga ttcaggcggc ggcgcaggga tacaggctga tattaaaacc tttcaagagc 1071721 ttgatgtatt cggaatgtct gcgattacgg cggtaaccgc tcaaaatacg cttggcgttc 1071781 acggggtgca tccgctgact gtagagacgt tgagacagca aattgacgct gttgctgagg 1071841 atttgagacc ggatgcagtt aagacgggaa tgctctggaa tgccgacatg attgaagaag 1071901 tggcaagaaa aattgacgag tacggattca atcgtgtaat tgttgatccg gttatgatcg 1071961 caaagggcgg ggcatccttg ctgcgtgatg agtcagttgc caccttaaag gagttgctca 1072021 ttccaagaag ctacgcgatt acgccgaatg tcccggaagc agaaacgctg acaggaatga 1072081 caatcagctc gctggatgac cggaaaaaag cagcggagca gctcgtcaag atgggtgcgc 1072141 agcatgtcat tatcaaaggc gggcaccagc ctgaggacaa tcacattact gaccttcttt 1072201 ttgatggcag catgtttatg caaatcaccc atccttatat caatacgaag catacgcatg 1072261 gcacaggctg cacctttgct gcggctttaa cggcccaaac ggctaaagga gacagcatcc 1072321 atcaggcatt tgaggttgcg gccaactttg tccgtgaagc ggtggaaaat acgctcggca 1072381 tcggatcggg acacgggccg acaaaccatt tcgcttttaa acgaaacagc ttaaatacaa 1072441 gccgatgaga tcaccagctg atggtgatct cttttgcgtt tgctacggta tgcgcttttc 1072501 atctggacaa ggttatgata tgataggaat taagatcagg tactaatact atgtctttat 1072561 taaatatagg aggctttata catatgaatt tttcacttga aggccgtaac attgttgtga 1072621 tgggggtagc caacaaacgc agcatcgcct ggggcattgc gcgttcttta catgaagcgg 1072681 gtgcacgttt gattttcaca tacgctggtg aacgcctgga gaaatccgtt cacgagcttg 1072741 ccggaacatt agaccgcaac gattccatca tcctcccttg cgatgttaca aacgacgcag 1072801 aaatcgaaac ttgcttcgca agcattaagg agcaggtcgg tgtaatccac ggtatcgcgc 1072861 attgtatcgc gtttgccaac aaagaagagc ttgtcggcga gtacttaaac acaaatcgtg 1072921 acggcttcct tttggctcat aacatcagct catattctct gactgctgtt gtcaaagcgg 1072981 cacgtccgat gatgactgaa ggcggaagca ttgtcacttt gacgtacctt ggcggagagc 1073041 ttgtgatgcc aaactacaac gtcatgggtg tagcaaaagc ttctcttgat gcaagtgtga 1073101 aatatttagc tgctgactta ggaaaagaaa atatccgcgt caacagcatt tctgccggcc 1073161 cgatcagaac attatctgct aaaggcatca gcgatttcaa ctctatctta aaagacatcg 1073221 aagagcgtgc accgcttcgc cgcacgacaa cacctgaaga agtgggcgat acagctgcgt 1073281 tcttgttcag cgatatgtcc cgcgggatta caggtgaaaa tcttcacgtt gattctggtt 1073341 tccatatcac tgcccgctaa gcaggctgtt aatgatgcaa gggctgtctt gctttctgta 1073401 gcaggggata caaaaatctt gagcggttgg ctgttttgcc gcgcctgtta gcagggcaag 1073461 acaaatataa atgctgtttc gcccgggtca tggctacata taaaaggcgt ctttcctcct 1073521 caagagcggc ctcgtctcct tttcttgccg tttctaatga gaaatcgtgc ggaatcgagc 1073581 catctacagt gcctaacacg tagactgttt tgaattcaag gccttttgac cggtgaatgg 1073641 tcatcagctg aacgccatgt tcatccgttc tgtttttctc agcggccctc atatggtcta 1073701 cgtgggcaag aaagtcagga atcgttttga acttcttggc gacaaccttg atgtcgcgca 1073761 ggtcatcaga gcctttttcc agcttgttgc cctcattgcc ccgctttttt aaatactcgg 1073821 agaagcccat ttttccttct gcaaaggtga tggcttctac gggtttcatt gtgcggaggc 1073881 ttgcaaaaaa cggtacgatt ttcttgattt tgtccagctg gaatggcttc agatcaggca 1073941 atttggccag cgctttgatc atggtacagt cctctgtaat cgagagcgcc ttcagcgtat 1074001 tcaaagcgga ctgttttaaa aacaaggcgg gaagcaagtg tttaatcgcc tcggtgtcat 1074061 cctcattttg gctggcgtac aagtaggcga gaatctggcg gacgatccgt ctgctgtaaa 1074121 acgattggac gccgcggtca gctgtatacg gaattgacga ttgatgaagc ctttcatata 1074181 tagcacggcc tccgctgttt gtgcggtaaa gaaccgcaaa gtcttctgga ctggctccat 1074241 tttgaatttt ttctttgata tcggaaacga ccattgtggc ttcttcctct tcatcataag 1074301 gataaaacag cacagggacc tgaatgtcat cgcgggccgc ttcaagcgtt ttggcatatc 1074361 tgtttttgtt ctttttcaca acgatatcag cactagagac gatcgggtgc gtagacctgt 1074421 agttcgcagt taaatagatc gtcttcgctc ccggataatc cttttgaaaa tcaagaatga 1074481 aagacggatt gcttccgcga aacgcgtaga tggactggtc atcgtctccg acacagcaca 1074541 ggttttgctc cgggctggcg agcatttgca tgattttgta ttgaaccgga ttaatgtcct 1074601 gaaactcatc aattaagata tacgtaaacc gagattgata ttgttccaga aggtcaggcc 1074661 gctcgataaa caattcatag caggctgaag ccatgtcatc aaaatcaaat tggctgtgtt 1074721 cttttttctg gcgttcataa tgttcatata aacgataaac ttgtttttcc cactcatctt 1074781 ttagagggat gcgttcattt gggacataag tgtttttcca aaaaccgatc tgctgcaggg 1074841 cttggtcaac tggggattct ttctcatcga tgccttcttc atagagtgct tttttgatat 1074901 attgttcccg ctgccactcc attttcagca gatgctcacc gttccattta gcagaattag 1074961 agtgatacaa gatcttataa aacagactgt ggaatgttcc tgtcacaatt cttctgactt 1075021 ttgccggctg taatccgtac tggttcgcca tacgctcttt catttcagcg acagcttttg 1075081 ttgtaaaggt gacaagcagc atattttcag gcggtatgcc taagtgttcg atcatgtggg 1075141 cggcacgggc tgtcagtacc cgtgtttttc cgctccccgc acctgcaagc acgaggagcg 1075201 ggccctctgt ttccgtgaca gctttcagct gatccgtgtt taaaccgaca gacggaaaaa 1075261 ggctcgtatc gggttctatt gtttttggca caaatggtgt tcctggttta atgcttctag 1075321 gacggtgcca ttctgtaaca gctggggacg ggtcagcggc gatcgctttt cccttgggta 1075381 aacgaatgac accagattcc tgatcatctt cttttttccc ctctttagag ggcttcggtt 1075441 cgcacgcctc ctcacatgcc ggaaaatcgc ctggctggcg atggataaac tctggcggat 1075501 cggcgatgtt aagccgtaac aaaacgggct ttccgcaatg agaacaaaat aaatgtcctt 1075561 ttattccctc ttcaaagagg aattgataat gttctctcga atatgtatgt aaatgtatga 1075621 ttctatcatt cagtcgggcg catttcaaaa aggggtcctc ccaatcaaaa ggtgttcatt 1075681 acagacaatg actatcatat caaaagaaat gtgtttcaaa aagtaagttt aagggaaaag 1075741 agacagcaga ggggtgggta ttgtatgata tatgcaggtc aaattcagaa ccagcaatac 1075801 gctcaatatg ctaatagaac gattggacat aagcaggatt atgccggaac cgaaaaaatc 1075861 agctatgtcc cgtttcagcg ggtatacaaa gaactggaaa agcagcagga gaatcaaacg 1075921 gcagctgaaa gaaaagtaaa cgagatgaaa cgtaagcgct ctctttataa gagattgcga 1075981 gaaaaaggaa tggggacata tattaatcga tatgtataaa aaaccgttca taccagagaa 1076041 cggttttttt atatgcagta aaaatccgga tctcaaaaga tccggatgcg ttcagtcctt 1076101 catcatttgt aagtgcggaa tgccggcatc gaggaattct ttttcagaaa gcacgcgata 1076161 cccgtgtttc ttgtaaaacg gcacagcctg tgtttgcgcg tttaaaatga aaccggaagc 1076221 gcctccgtct gccgcggctt tttcgagcgc tttcataatg atgccgccga caccggctga 1076281 gcggtggctt ttcagtacgc aaatccgctc taacttgccg tagccgtcct tcatgcgcca 1076341 tcttccggca ccgacaggct tttcaccgtc atacacgacg atatgctctg actcattttc 1076401 aagttcgtca atttcttctt cagcaggcac gttttgttct ttgacaaaga cttcttctct 1076461 tacatagaat gcatctttca gttgttcttc attttttgcg ataactgctt tcaaacatta 1076521 ttctcctctg cctagcaaga aggtttcata tactgtccac gatccgtttt ccaactggta 1076581 gagcaagtgg aaacggtcaa cgatttcttc atgcgacact tcctgcattt ttaattgtcc 1076641 cagcacatct gaatgctcat cgtcggaaag attttggccg accgtcacat gcggaacgaa 1076701 attatattcc tgttctcctg ccaacacacc ggtgtatagc ttttcattga gtgtttttaa 1076761 ctcttccgtc ggttctgctt tgatgtaaat gacattattg acaggcgcaa atgagctgta 1076821 ttttgtcatt ttgagaacga gtgggtggga ctcttttgcg atgtttctta aatgtgatac 1076881 gagctgatcc gctttctcct ccgcgcattc aaaggatgct ctcagcgtca aatgaggcgg 1076941 gattagagag tagcttgggt catagcgctt tctgtaagag tttgcaaggt cttggagctt 1077001 ttttgatgga aataaaacga ttccgtattt catattatgt ccctcctgga aataaagtat 1077061 gatagagtgt taaagcattt ttttcagcgc cggggtgatg agcggctgcc agtatgtcca 1077121 tttgtggtct ccgtcaaatg gctcgaaatc ataatcggaa agctttttct ccagcagctg 1077181 tttcagctcc cggttcggtt ctgtaaagtc cagaatgttc ccgtctgtcg tgtggacgtc 1077241 agtttctttt gttccgattt ggtgataaat agagaggtgt ttgatatcgt ctgactgttt 1077301 tacggcttct agtacgtgtt tgtcaacata gggagactgc atgatgatgt tgccaaacat 1077361 attcggataa tcaagcgctg tcataagtga cacggttgct ccgagcgaat caccgatcag 1077421 cgttcggccg taaccgatct gataggttgg atactcatca tctgcaaaag gaacgagctc 1077481 atgggcgatg aaccgtttat aagccgaaaa ttttgaaccc tccggatgat aagtgtttct 1077541 gcgctctttt acatccttat agggaacacc gataataatg ctccggtcta tttcgcgttt 1077601 cgacagcaat tcctcaacct gtctgccgat tctccccagc ctgaaataat cgtggccgtc 1077661 ctgcgcgata atgacatggt atttataaag cggggagtag ttggacggca gataaacaag 1077721 caaggtcatt tcctcgttaa gctcttttga aaagaatttc ttttcttgca ctgtgccgtt 1077781 tttcggtgcc ataaaaacat tcctccagga catcactata ctttcttgca ttttcaatta 1077841 ttgtaccatg aattattaga aatttctctc tttaaacggt tcggcacacg aagaaaaaag 1077901 tgttgaaata aactgtgaat tgcgctaata taaaacaatc agaaaattga aatcgatatt 1077961 tcttatcgtg agaggtggag ggactggccc ttagaaacct cagcaaccgg cttgttttgc 1078021 atttgcaaag cgccaaggtg ctaaatccag caagcgtttt ttatgcttgg aagataagaa 1078081 gaagcgttaa accccttctt cttatgaaga aggggttttt attttgaaaa gggaaggtgt 1078141 cagctatatg tcacagcacg ttgaaacgaa attagctcaa attgggaacc gtagcgatga 1078201 agtcacggga acagtgagtg ctcctatcta tttatcaaca gcataccgcc acagagggat 1078261 cggagaatct accggatttg attatgtccg cacaaaaaat ccgacacgcc agcttgttga 1078321 ggacgcgatc gctaacttag aaaacggcgc gagagggctt gcctttagtt cgggaatggc 1078381 tgctatccaa acgattatgg cgctgtttaa aagcggagat gaactgatcg tttcatcgga 1078441 cctatatggc ggcacgtacc gtttatttga aaatgaatgg aaaaaatacg gattgacttt 1078501 tcattatgat gatttcagcg atgaggactg tttacgctct aagattacgc cgaatacaaa 1078561 agcggtgttt gtggaaacgc cgacaaaccc cctcatgcag gaggcggaca ttgaacatat 1078621 tgcccggatt acaaaggagc acggtcttct gctgatcgta gataatacat tttatacacc 1078681 ggtcttgcag cggccgcttg agctgggagc tgacattgtc attcacagcg caaccaagta 1078741 tttaggcggg cataacgatc tgcttgctgg acttgtcgtg gtgaaggatg agcggctcgg 1078801 agaggaaatg tttcagcatc aaaatgcaat cggcgccgtc ctgccgccat ttgattcgtg 1078861 gcttctgatg agaggaatga agacgctgag cctcagaatg cgccagcatc aggcaaacgc 1078921 gcaggagctt gcggcgtttt tagaagagca ggaagaaatt tcggatgtgc tgtatcccgg 1078981 aaaaggcggc atgctgtcct tccgtctgca aaaagaagaa tgggtcaatc cgtttttaaa 1079041 agcactgaag accatttgtt ttgcagaaag cctcggcggg gtggaaagct ttattacata 1079101 ccctgcgacc cagacgcaca tggatattcc tgaagagatc cgcatcgcaa acggggtgtg 1079161 caatcggttg ctgcgctttt ctgtcggtat tgaacatgcg gaagatttaa aagaggatct 1079221 aaaacaggca ttatgtcagg tcaaagaggg agctgtttca tttgagtaaa cacaattgga 1079281 cgctggaaac ccagctcgtg cacaatccat ttaaaacaga cggcggaacc ggggcagtca 1079341 gtgtaccgat tcagcacgcc tcgacttttc accaatcttc atttgaagag ttcggggcat 1079401 atgattacag ccgctctggc acgccgacaa gaacagctct cgaagaaaca attgccgcac 1079461 tggaaggcgg aacaagagga tttgctttca gttcaggcat ggctgccatc tcaacagcat 1079521 ttttactgct gtcacagggt gatcacgttc ttgtgacaga agatgtatac ggcggaacct 1079581 tccgtatggt gacagaggtg ctgacccggt ttggcattga gcatacgttt gtcgacatga 1079641 cggatcgtaa tgaagtggcg cggagcatca agccgaacac aaaggtcatt tatatggaga 1079701 cgccatcaaa tccgacactt gggattacgg atattaaagc agttgttcag cttgcaaaag 1079761 aaaacggctg cctgaccttt ctggacaata cattcatgac gccggcactg cagcgtccgc 1079821 ttgatctcgg cgtggatatt gtacttcaca gcgcgacaaa attcttaagc ggacacagcg 1079881 atgtgctctc aggtttggct gctgtcaaag atgaagagct tgggaagcag ctgtataagc 1079941 tacaaaacgc gttcggcgcc gtccttggcg tgcaagattg ctggcttgtc ctgcgcggat 1080001 taaaaacatt gcaggtccgt ttagagaaag cgagtcaaac agctcagcgg cttgcggaat 1080061 ttttccagaa gcacccggcg gtcaagcgcg tgtattatcc gggactggct gatcatcccg 1080121 gcgctgaaac ccataaaagc cagtcaacgg gagcgggcgc cgtgctatct tttgagcttg 1080181 aaagcaaaga ggccgttaag aagttagtcg agaatgtgtc actcccagtc ttcgctgtca 1080241 gccttggcgc cgtggaatcg attttgtcct atccggcaac gatgtctcat gcggcaatgc 1080301 ctaaggaaga gcgtgaaaaa cgcggtatca ctgatggcct gctccgtctg agtgtcggcg 1080361 tcgaacatgc agacgattta gaacacgatt tcgaacaagc gctgaaagaa attgctccag 1080421 tttcggttcg ttaaaaaaga agccggggat agtccggctt cttttattat tgttcgtcat 1080481 caggattcag aatcgcgagg acttgatgat cctcccaaac gccattaatt tttacatttt 1080541 ttcgggcgat gccttcttta tgaaatcccg ctttttctaa aacacgcatg gacccgagat 1080601 tacggggcat cacaccggct tcaatccgat gcagtttcaa ttcgtggaac gcataatcaa 1080661 caaccaatct gactgcctct gtcataatgc cctttccatt atgggctttg tctaaaaaat 1080721 acccgatgaa cgcagtttgc agcgcgccac ggatgatttg aaagagcgaa accgtcccga 1080781 ttaatctatc gtctgacgct gtaaagatgc caaaatgata ttcttcatct ttctcaagtc 1080841 tttcctgata ctcggttatt cgttttcttt gcccctcaac cgtatagtaa tcgtctgcgc 1080901 gtatcataga aaactgttcg aaaaaatctc gattttcgct ttgcagcccc agattttctt 1080961 cggcatccgt tacttctaaa ggtctaacat aaatggtttt tccttttaac atatagtgat 1081021 ctctccgttc tcatgtcagc attcctctta cattattctc agggaaatgc aaatatcctt 1081081 tttataagaa ggaagaaaac caatttccca taaaagtgcc aacatagttg ccgattaagt 1081141 agccgagcgt accgacaagc atgatcgggg cgacaagctc ccgccatccc ttggcaattg 1081201 ccatcgcagc cgcagtcgtc ggtcccccga cagtagcgtt gacggcgagc agaatttctt 1081261 caagccgcac acggaacaat tttccggcag ctaaggaaac cgctaaattg ctaatcgcaa 1081321 tgataaacac gaataataga ataagaggcg cattcgtgac gattaagcgg agatctgcag 1081381 gaatgccgat caccacaaaa aacaaataaa tcaaaaaggt tccaagctcc tgagatccat 1081441 tgagcctttc aaaaaaacgc gggaaaagaa aaatgataag aacagttaaa gacgtaagaa 1081501 ccaggtactg atcgccaagc gtaccggtca gcaggggatg agaaaaaatg cttttaaaat 1081561 aaccggaaac cttcatacta accgcaacaa gcgcgaaagc ggcaccggca ttaaaagcga 1081621 tatcctttaa ggaaatatcc ttccgtttcc aatagctttc agcactgttt ccgctgtttc 1081681 catcggcttt taccttctct tcaaacggca tggcataatg ccgctgaaac catttgagtg 1081741 caggaatgct gattaaaata aaaaacaaaa gcgccatcat aaaattatca gccacaacgg 1081801 tagccgacac atattcacca ggcgtctcaa attttgccgc catcgccgca aagttgaccc 1081861 cgccgccgat ataagaggcg ctgatcatcc caccgatttt atctaagtaa ggaatatgct 1081921 gtttgagtag aaaaaaagcc aggatactgc caagcactgt tccaacggag ctaatcagaa 1081981 aaataaacag caaacgcctg ctttccttaa aaatttgcct aacattgatc tgaaacaata 1082041 aaagtggtat cgccagcggt accacataag accacacagt gtcatacacg ggcgactcaa 1082101 caggaagcac tcctacattt gtaaacacca tagcacctgc aagggcgata atagcgcccg 1082161 acacagcaga cgcccactta aagcgctgct ccagcccgat gctcactgcc gcccacaccg 1082221 caataaaccc ccataatacc catacatcat cagaagaaat caaagaatgc aaaaccccat 1082281 cacctctatt gttagaaaat taagacatat tataatagcc ggggaacgga acagcaagtc 1082341 caaaaaaagt ttttctaaaa aagcagttga cgaatagaag gtaaggttat ataatagaac 1082401 ttgtcagaaa gataacaaca tacccagcaa cacatacata tcatgattcc gtagctcagc 1082461 tgggagagcg ctaccttgac agggtagagg tcgctggttc gagcccagtc ggaatcatag 1082521 cttaaaccct tgcgcagcaa gggtttttta ctttgcgtta ataaagccgg ttcgtcaaat 1082581 tcgtgagttg ttggcgaact gttggcgaaa ttcattgacc gcagtccaaa aactacctcc 1082641 aaacttactt gattagttca atagtaacaa acggaagatc ggatttctgt taaatcttca 1082701 ttgagaatag ccagtccaag accgtcactt cagccatgca tcttttaaat gaaattttgt 1082761 actgaaaaca tcaattgtat ttttaaattc tgctctagaa tcagcccctt tataataatc 1082821 ttgataaatt gcttggggtg atactgattc gtgatttgtg ctatggtttg caaggcttgt 1082881 agcaaaagca ggagcaacag taacgagtaa agcaagggat aatgcaaaac cagttaaagc 1082941 tttttcaatt tcattttaag cacttctttt tttaaaatac aactttatta ttaaatggaa 1083001 tacaaaaaca tccaaggtgt ttttttgtta gtaagttgag ttagggggat tggatggcac 1083061 ttagaatatt gtttctgctg atgggatgtt gattctggat atatttccaa cacgattaca 1083121 ggccggacat gaaagcgaac cttgctttga tcggggcaat catttcattt acggctgcgg 1083181 tttactttaa agatattgat gtattgagag aagagggaaa acaaatgaac ggaatttctg 1083241 agcgttggaa cacgtttaaa ttacaaaaat cccctgaacc actctagatc aggggattgc 1083301 tttcccaaca gcttattaag tagcggaagg catgatcaac gatttagtat caatttatta 1083361 attgcgaata ctagaaacat accgttttcc gccttcctta gaagtaacat attctcgagg 1083421 aacattaagt ctattggtag aatgataact tacataaagt ttcatatttg ctcggctcgt 1083481 tacgatagcc gtatgatcca tccaaccatc agcatagcga agacctattt tattatggta 1083541 atcatagtga tatacatctc caagctttac atttgaatat gtatcagaaa cagtcttcat 1083601 ttttattccg ccagctttta aaatgtatga tctaaaggct cctgcattaa cccaagcatc 1083661 tgtatagggt ttccattctt taaagtacgg cattcttcca gctcttaatg cttgggaaac 1083721 aaagttagta caatctttgt ctttataata tttatagttt ttatttggtt ttaaggcata 1083781 tttttctgca tatttcattg cagcgtaacc actatatcct ttaacagatg ttgcagtcac 1083841 agttagttga ttagagttag cagcattgaa gttcatactt actggtttat cttcactttt 1083901 cacttcttct ttatcatcat ttttcacttc ttgcttatat ttttttaaaa attcatctaa 1083961 tttaacatcc gaagaatatt cttcatcatt ttcatattgt agagttgaag aagaattatt 1084021 taattgtgtt acatttagtt gcttagaaga attactcaat ggtattacat ttagttgatt 1084081 agaagaattt ttaacttgag agaaacttag attagaagta tttgttgatt gagaactttg 1084141 tttattagaa gttgttttgg gaatttcaag tttaatatta tcgcccagag atgttgttac 1084201 tttttcaaca ccaaaaacaa agtttcgagt aatataagct tcaacaatta gcttattgtt 1084261 tttttcagaa gtcttaacat cgtctatatc gtatgtaaac tcgtggaatt tttgtttgtc 1084321 cactttactt aacgcagaat acagtaagac tccttcgtcg gaatcagtca atttagactc 1084381 tttaggatgc gctaaaggag tgttgtgttc aaaatcatat ttttgttgtt ctaacatatc 1084441 cttaactttt tcgtaaccaa tctcgttggt aattgaaaca ttttctttag tctctttatt 1084501 agtagtggct gcaaaaactt catttgttga cactaatggt gacaatgata gacataaaac 1084561 tagtgaagca agtaattctt ttttcatacg aaacctccaa taaaatctaa atataagtaa 1084621 tatttatcat ttacaccaat tgaaatatgg cataaaatac atgtaataat ataacataaa 1084681 aataaataca taaaaaggta tcggaggaaa aaatgaaaaa gaaaactaaa attatacttt 1084741 ctctcttggc agcacttatt gttatattga tagtacttcc agttctatct cctgttgtct 1084801 ttacagcttc ttcggaaaaa ggagcaatca gacacgaaat ttataaaaga ggatatccct 1084861 accaaagcta ctttgcagtt ctccagaaaa gagaaggaga caatgaatct gggaatcttt 1084921 attatgtaaa ttggctagat tggaaagatg aaacagggca aactcctcac ttatgctatt 1084981 cgaaaaaatc atcagatggt gaatacgaag taagttgtgg cacagggccg taaaaataaa 1085041 ttttaaaatt gaataagtcc aagacggaaa gcctgcggac actgatcgtt ttacagagaa 1085101 atttgtgctt cgatcggtgt ccgttttttt tcgcaactaa ccagatgtct atcgcgatta 1085161 ctagctatga aaggagtaat tagacatgaa acagtccaaa aagaaaccat cacagaagca 1085221 acatgagcgc ttagatcgtt tctggcaaca aatgatgaac actaacatgc aaacactcag 1085281 acgtggcaaa ggcggcgctt ataaacgcag aaagtaaaaa gggagtttga ggatgatgaa 1085341 aaacggattc gcttataaaa acggaaagct tgtgaatatc ttttgcggca aagaagagct 1085401 ctataacgag ttgaaagcct tcttggtcaa aaccttcagt atcaacgtga aagaggtatc 1085461 gaggccctca atatatcgca gaacaaaaag caaacaactg gaatgacact tactctattt 1085521 aactatcagg agggaaagca ctatgacaga tcaaatgatt gcatgggaga ttgaggaatg 1085581 gattcgtgat tataaattca tgctgcggga gatcaaaagg ctcaaccgtg tattaaacaa 1085641 agtggatttt attagcacaa agctcactgc aacatacggg gaggaagcgg gcatgccaag 1085701 gggatcagca ggcgtcagtc aggcagaatt gcggcagatg gaccgaagag aaaggcggct 1085761 tcacaaatat gaatctattg tgcattacct ggacaatgca atggaacaca ttgaagaaga 1085821 aaagcaccga atcgtttacg attgcatgat ggaaggcatg agctacactg ctattgcaaa 1085881 ccaccttgat tgctcccggg ataccatcag aaagatcaaa acagccataa tcggcaacat 1085941 cgtcaataaa gtcaaagaag ccaactttct gcaatatttg aattcgttta aatcggcggt 1086001 gtaaaatggg gggcaggatc ggcgcggcgg attattcctg cgtcaccacc aatttcatac 1086061 aatgagtaaa acctcccagt ggtaagcgag gatcaactca actgggaggt cttacatagt 1086121 gaatcggtga taaaacagca gcagtattgc gtacatgtta atatccccga caaaatatgt 1086181 ttttttcaac agattcgttc gacaaatttt gcaaattgtt aatcgataac ttttcattcc 1086241 cgatattaaa aatgggagtg aattgtaaaa tgaaaaaaca gaaaaataat aaaaagaaga 1086301 atattgaaaa gcgaaatatt gaaaagcgaa atattgaaga gaagaataat gaggacttag 1086361 aagaactgga aaatgcgatt tatacttatc acaaaaagga gctacttgct ttctttcttg 1086421 aaaaaactcg aattggtcat gataaggaag aatacaaaag gttccaatct cttctttata 1086481 agttggatat tgaatgttta gaatttgcta tatcgagatt ttctcatata gatattatcc 1086541 atgatcattc aaaatatgtt ccagccttta tccctttatt tgcagcatat ctcaccatgt 1086601 tctttaattt ttatgaaaaa cattggggag ctttatcttt tgctgctggt acaattgctg 1086661 ctattgtttg gataattgca gtagaaagaa aacatagaaa tcaagcaatt tctattatga 1086721 aaatatttga acaagtcaaa gagagaaaag tgaaagacag atctaaagac tgaaaggaga 1086781 aaatatgaat aaggataaat taaggtatgc aatcttaaaa gaaatttttg aaggtaatac 1086841 ccctttgtca gaaaacgata ttggagttac tgaagatcaa tttgatgatg ctgtgaactt 1086901 tttaaaacgc gaagggtata tcattggggt ccattattca gatgatagac ctcatttata 1086961 caaattagga cctgaactga cagagaaagg tgaaaactac ttgaaagaga atggaacatg 1087021 gtctaaggcc tataagacca ttaaagagat taaagattgg attaaataat aagagcatcc 1087081 tgcggggtgc tttttttgtt ccctgtaaac tgcttccggt aagtctcagg atagacaatt 1087141 ggcggttaac ggcttgagca cggtggtggt ttagagggaa tatcttttcc aaaacaacac 1087201 gaatcagaag ggggcggcgg tgaatgtaga tggccgaaaa gcacattcag gcgtataagg 1087261 attacgtcaa aggcatgaaa tacaaggacc ttgccgagaa atacggggtg tcagtgaaca 1087321 ccattaaatc gtggaagcag cggcatggtt gggaaaggaa aaagggtgca cccattgaaa 1087381 aaagtgtgca cacaaaaaaa ggcgggcaac cgggcaacaa aaatgcatta gggaacaatg 1087441 gcggcgcacc acagaagaat caaaatgctg tgactcacgg ctttttctct aaattcttgc 1087501 cagaagagac gcttgaaatc atggaagaga ttcaggagcg ttcgccagct gatatgatat 1087561 gggatcagat acagattcaa tatgcggcca ttcttcgggc gcaaaagatc atgttcgttt 1087621 ctgataagga agaaatgatc aaagagctga aaaagaaaag gtccctcata tctgaggtca 1087681 gcgaaattga agatgggctt gtcattagtt ttagtacgtg gtttcgctac agactttaca 1087741 gtgaaacaaa cacctaacac atttcacatt gcttcagatt gccttcaaac ttgataatat 1087801 aacttctaaa ccttcctata aaatgaaggt tttttatttg atttcaattt ttaaatcctt 1087861 tacatacagc gattgattaa ctcgagcaat caatgtcgca gttatattta tttttcaaga 1087921 aaatgttata atgaaaagcc ataaaatgat gggaggggga atttcgatgc attacataac 1087981 ggcatgttta aaaatcatca gtgataaaga ccttaatgag ataatgaagg aattcaaaaa 1088041 acttgaggaa gaaacgaaca aagaagaggg ttgtattaca ttccatgctt atccgcttga 1088101 gccatcagaa cgtaaaataa tgctttggga gatttgggaa aacgaagaag ctgtgaaaat 1088161 ccatttcaca aaaaaacaca caatagacgt tcaaaaacaa gaattaacgg aagtagaatg 1088221 gttaatgaaa agcaatgtga atgattgaaa ggctctttaa aaagagacat tcaatgactt 1088281 agtatcagcc acttgtgact aagtagtaaa ttgttgtcca actcttattt tttctattta 1088341 atattttttg agacgaaaat gtttttttaa gctgatttta aaatgtattc aaagtcagct 1088401 ctgtttgatt taatggatta tattatttgg atagcttgtt accatcataa tggagatact 1088461 ccttataaat tggaggttaa aataatgagt cattctcaag aaaaaattgc actaattaca 1088521 ggagcaagca gtcaagggga tattggtacg gctatttgtc gtaagttagc ctcacagggt 1088581 atacatatct tctttactca ctggaattct gatacggcct ggatagaaga atttcaacaa 1088641 gaaattttac gtatgggtgt ccgctgtgag gcaatgaaaa ttgatttatc agatgcacat 1088701 gctgcattca caatacatga aaaaatttca gataaattag gatatccttc catccttatt 1088761 aataatgcag ctcattccgc aagtgataat tatgtatcgt tagatgctaa atcacttgat 1088821 gagcattatg cggttaatat gagatcgaat tttcttcttt gtgttgaatt cgcccgtcgg 1088881 tttaaaaaat ctaatttaat atcaggaaga atcatcaata tgacatcagg gcaggattta 1088941 ggtcctttgc ctggggagtt agcgtatgca gcaactaaag gagctatttc tgcatttact 1089001 aggtcgttat cacaagaact tgcaccattg ggcatcactg ttaacgccgt aaacccaggt 1089061 ccaacagatt ctacatggat gacagatgaa ataagaaatt ttctttcacc taaatttcca 1089121 atggggcgta ttggcacacc agatgatgca gcacgaatga ttgcctttct tgcaagtgat 1089181 gaggctgaat ggataactgg acaaattatt cattcagaag gtggatttat tcggggctaa 1089241 gctaatgaaa cacggtatac accaatgtat gatgtattcc caaaactaaa tctaaacttg 1089301 aagcgaaaat aaggtccctt ctctttttag agggggacct tattttattc atgcatgttt 1089361 tgcatccaga aaatctggcg gataaagatt aataaaccgt tacatatact tttccgaata 1089421 ctgcagtacc tttaaacaaa gtaatcgtgg ctttcccttt tgatttagcc gtcactaaac 1089481 cattttgatc gacttcagca actttttggt tatcagtcca ataacgagta gctgaattat 1089541 ttttaacaga ataggtttct ccaactttta gaggtaaatt atagtcttga atcttgataa 1089601 catgtgtagg tgaaatagaa atgttcttta cttcagtagg tgtggagttt atttcatgag 1089661 ctgaagctac cccgctgacc gacagagcta acgcagaaat cgataaagca gaaacaaccg 1089721 tttttttgaa attcattttg aaacactcct ttaaagtttt ttgtcttgca ctataacaat 1089781 tcaataaaag taattatttt ccttgtaaat aaatgttaat aatatgtgaa cgatcaattg 1089841 atttgagcta agaatattgt gtgccctgca cagagtttgt atttatgatg gaaaattgct 1089901 gagagagaat ggccatcctt aaaatgttaa tagcacacat ttgatgggta ttagtttgtt 1089961 gagcgtgtgg aaattttgtt acctgcactt tatccccgaa gataccaaat cacttttctt 1090021 catcatgttc ttactttcgt actcatacat tagaaaatct tcgttctaaa taggtgaaga 1090081 attggagtat ttttatgaat ttctgctgaa tatacattac atagcaaact caaagagtat 1090141 aaaaatcgct tttttccgga agcttcggta aaaaacgaaa cttttgtctc tatgattttg 1090201 ttttataatg taaacggttt cttatatagt atacttatac tatcaatttg ctcaagtaga 1090261 tactgacagg aaggatagaa aaacagatgg aatacataaa tacaagacaa aaagagattt 1090321 tgtatctgtt gttatctgaa cctgatgact atttagttgt gcaagatttc gcagataggg 1090381 tacagtgttc tgaaaaaaca atccggaatg atttgaaagt gatcgaggat tatctcaatg 1090441 agcattctca tgcacagctt attcgaaaac cagggttggg cgtttattta catatagaag 1090501 aacaggaaag gacctggcta agccaacaat tacatactga acatttttct tctaggcagc 1090561 ggagcgataa ggaaagaatg ctgcacattg cttatgactt attaatgaat ccgaagcctg 1090621 tttccgcaaa agacattgcc gctcggcatt ttgtcaatcg atcttccatt aaaaaggatt 1090681 tatacgcagt agaagagtgg ctgaagcgtt ttgatctcac actggtttct aggcagcggc 1090741 ttggattaaa ggttgaaggg aacgaaagaa ataaaagaaa ggcattggca agaatatctg 1090801 atttgattca caatacagcg tttaccagcc aatttattaa aagtaagttt ttacattatg 1090861 aagtagactt tgtgacgaaa gaaatcaaat cactacaaaa aaagcattcc ctctatttca 1090921 cagacgaaac gtttgaaagt ttgttgctgc atacattgtt aatggtccgc cgcatcaaaa 1090981 tgaagcagcc gatttcattg tccccaaaag aaatggcggc agtaaaaaag aagaaagaat 1091041 atcaatggac atttgcttgt ttacagcggc ttgaaccggt ttttgcaatt cgcttccctg 1091101 aagaagaagc cgtgtactta acattacata tattgggcgg taaggttcgt tatccattgc 1091161 agacagaaga gaaccttgaa aatgctgtgc ttcctaaggt tgtagggcat ttaatcaatc 1091221 gtgtttcaga gctgaaaatg atggattttc acaaggatca ggatttgatc aatggtttga 1091281 acattcatct caatactgtg ctacaacggc tgagctacga tctttctgta gcaaatccta 1091341 tgctcaatga catcaaaaag atgtaccctt atttgttcca cctcatcatt gatgttttgg 1091401 aagacatcaa tcaaactttt gatcttcata ttcctgagga agaggcagca tatttgacat 1091461 tgcattttca ggcagcgatc gaacggatgc agggcagcag cgagacacat aaaaaggcgg 1091521 ttatcgtctg ccacatgggg attgggatgt cacaattgct gcggacaaaa attgaacgga 1091581 aatatcacca aatcgctgta atggcttgta ttgcaaaggc cgatttaaag gattatatca 1091641 aaaagcatga ggatattgat cttgtcatat ccaccattgc gctggagaat ataacggttc 1091701 cccatattgt tgtgtctccg cttttagagc ctggcgaaga gaagaaatta agtgcgttta 1091761 tacgtcagct gggcgaatca caccgccaaa aacaaaaaac gtttcagatg ctgaacaata 1091821 cgactccttt tttggttttt ttgcagcagg aggcggagca tcgctacaag ttaatcgaac 1091881 agctggcgac agctttgttt gagaaaggct atgttgataa ggactatgcg gttcatgcgg 1091941 tgatgaggga aaaaatgtcg gctacaaata ttgggtcagg cattgccatt cctcatgcaa 1092001 acgctaaatt tattaaacaa tcagcaatcg cgattgccac attaaaggag ccgcttgaat 1092061 ggggaaatga aaaagtttcg ctcgttttta tgctggctgt caaacacgag gatcaaacta 1092121 tgacaaagca gctgtttagc gagctttcat atcttagcga gcagccggcc ttcgtccaga 1092181 agctgacgaa agaaaccaat gtcatgacat ttttatctca tttggattat taaaagcagg 1092241 gattattcct tgcttttttt gttcatggca gggcttgaga aataaatttg cgagtgaaga 1092301 cgcctattct ccagcaatga tctaaataaa ataagagttt aatagttgga gaagaaatgt 1092361 tacactcttt tctgtatatg gtaaagaatg aaaaaacacg attcggttgg tagtccggat 1092421 gcatgattga gaatgtcagt aaccttcccc tcctcgggat gtccatcatt ctttaatatc 1092481 ttttatgagg agggaatcgt tatgaaatta acgatttact acgatggtca gttttgggta 1092541 ggcgttgttg aagttgtgga caatggaaag ctaagagcct ttcgtcatct ttttggcaaa 1092601 gagccgaggg attctgaagt attagagttt gttcataacc aacttttgaa tatgatggcc 1092661 caagctgagc aggaaggagt gcgtttacaa ggcaggcgtc aaaaaaagat caatccaaaa 1092721 agattgcagc gccaggtttc aaaagagttg aaaaacgccg gagtaacttc taaagctcaa 1092781 gaggcgataa agctagagct tgaagcaaga aagcaaaaga aaaaacaaat aatgaaagaa 1092841 caacgagaac atgtaaaaga gcaaaggtat atgctcaaaa agcaaaaagc gaaaaagaag 1092901 cacagaggta aataatccaa acaaaagcag gcgcagtgcc tgcttttgta attaaggact 1092961 ctactttgta acatatatcc aatgtttata ctccgctgat ttatgattca atataaaccc 1093021 taacttctcc aaggtttttt gtgagcctag attatcatgt tcgcatcttg cggtgatccg 1093081 ggatactgtt tctcggctta atgcccagtt tattagtttt tgggcggctt ccacacaata 1093141 acctttgcgg cgatgacttt tatttgttgc aaaaccgatt tcaatcatgc cattttcgtc 1093201 tgggtcacct aaaaatccag ttcccccaac aatttcataa ttgtccttct ttacaataat 1093261 ccatgaatca aatccttttg ttccattgtt tttgactaaa atctcgcgga aataaggtat 1093321 cgcttcaaaa aaatcagaat ttggccattc accatttgtt tcatagccta attctttgat 1093381 agcctgatga tcttgtttag acgcggcgtc aagaagggga atatcaatcg tttgtaatcg 1093441 taatcgattc gtttcaagga gaaccatata tttaatcctc ttttcttttt actgggaata 1093501 atgataacat ataacaattt tctctggtac cttggcagta gagaaagatg aaaaaattga 1093561 gggggattga aagagtgaca ggtgagagtt tgcccagacc aaaaacgggt aggaaaatgc 1093621 tgatgttaat gtgtccctac ccgtttttct gttcctgaat gcagggtttc tgataacatg 1093681 ttgtgctacc ttttcgcaat caaataaagc gatatggctc tttgggtttg cacaggatta 1093741 tgaatgataa tgacccattg gtttcttcgt cttggaaagc ttgctaccgc atacaatgga 1093801 gcagtatcgc gcggagtgaa cccaccattt atcacgttga tatctcttcc ttcaagatga 1093861 caaactaagt attcacctgg attgatgacc tgttggttcg tccatgcgta agaataaaag 1093921 ccgtctccaa gatcttcggt ggaagatggg gggacaaagc catctacagt caatgtgatt 1093981 tctcttcttc gctgtctttc tgaaaagtct ggacttcttt gagggttatg agtatgtgaa 1094041 aagtaaggaa ttaacgcagg gccataaaag taatgataca aagcaaccac tcctttattt 1094101 tccattcata caaattgtat gtgggagtta tttgttcatt cctgttttgt tccatgtaga 1094161 ctaataatgg gctataggcg tccaaggaaa tcaatttgtc cttccgttga ttcaatgcta 1094221 gtaaccttga aaatgcaggt taggatgata gaatttacat attactgcaa gaagttagac 1094281 atacatcatt ttgatagtgg gtgaaaacaa tggcgaaaaa aatggcaaaa acaaatgcgg 1094341 ttcgtctgat agaacagcag aacatctctt atgaggtatt agggtataaa acagacggcc 1094401 agccggtaga tggcatctct gttgcggaaa aaatcggtta ttctttgaaa tatgtatata 1094461 aaacgttggt tgcagcagca ggaacaaatc attattatgt ctttgttgta cccgttgcag 1094521 aagagttaga tgtaaaaaag gcagcaaagg tgacagggga aaagaaaata gaaatgattg 1094581 caatgaagga gctgttagcg gtaactggct atcttcgcgg cggctgctcg ccaattggca 1094641 tgaaaaaatt gttcccgacc tatattgatg catctgcaga aacgcttgat tttattattg 1094701 tcagtgcagg gaaaatcggt atgcagctaa agttggcgcc acaagattta gccagatcat 1094761 gtgatgccgc atttgcagaa attgtataga tgcagatata ggggaacgaa aaagcttagt 1094821 catatcgatt aagctttttc cgcatccctt tcaaatatga tttcaaaata agcagctgcc 1094881 ccatacccat ctatactggg agcgaaaatc tgaacgaatc tccagcctct tttcgcataa 1094941 tcatggatga tttgctggta gtcttcttta ggccttcttc tcatcgtact cagctcaact 1095001 cttacgaatt catattcttt catcgtttga tccctcctat taaggtatac gtaaaatgga 1095061 gcgagaagtt ccgaaaacct aggttaaggt cggaaagtat atttcactca ctaaacaaat 1095121 ccatttatgc ctgatgcctg catgcatctg ggaagagtta aggggctata aaaacgaatt 1095181 ttaccgggtc agcagtccaa atgaatctct tgcttattgc atttgactga gtatataagt 1095241 aaaaaaagag cggccagaac atataagaag gagatgatca ttaacgcact cataacaggg 1095301 tagtgtttag cggagtagat gaaaaaatca agctgtgaaa tttgtttggg gctgctgacg 1095361 gcatcaattc cattaagcag ttttgagagt ttagcagtat agttccaatc aaatcgatct 1095421 gaaacaagct cgcttccttg ataccaatta acagcagcta aaaacagaaa taccataata 1095481 gaaaatccaa gctgaacaac taaaaatatt cccttcactt ttgtatgacc tccaaatcta 1095541 tgaatatggg aaaatcaaac aatatattac caccgtatgg gttattcttg caatttcact 1095601 tccatacaac tcaaacgcaa gtctattttt ttgtttgttt ttggcttata atacctgatg 1095661 atggaaaaag agtgcgggtt tatagattag agaaacaaat gtatttctta gcatttttta 1095721 tttgtggaga gagtatagaa gcattcgatt agatctgctt tttcacagaa acggttttca 1095781 tctgtttgcc tgagctttac aattggctgg caaaaaaaca atgatttctt tcaatcaaaa 1095841 catgcaacga tgcgacacat tttatatctt gatgacttat ttcattgcct ttaagtcatc 1095901 ctatcgagaa agcgatggta ttttatgaac aaagaaaccc taaaaaacat actcatgatt 1095961 ttttcaatat gcgcaacact ccgagaaacc gatggtatgc gcatagctga tagctggatt 1096021 ttgagtgaga ttatacgatt tttgatttgc atggttgtgt tttttgccat gacatttcta 1096081 ttagatgctg tttttccaaa caaaaaagag tcacattaat gtgtggctct ttttgcatca 1096141 tctgatcaga aacatcataa atgaatcgat catcatgatg aagaacagca agcaaaaata 1096201 aataagcgag tagacaaaca tatcctttgc ccacttcacg tcatcgtctg ttttgaatcc 1096261 tttgatgctt tttttgatcc atatgcctcc gagaaccaag gcggctaaga aataaaatgg 1096321 gcttatatgg ccggtgccga gagagaaagg aaataatagc gtgaccggca ccaggacggc 1096381 aatatattgc atcattttta tttttgttac atgattgcct ttgactactg gcaagagcgg 1096441 aacgccagca gcgcgatatt cctctttgcg tcttatccca atcgcccaaa aatgcggcgg 1096501 ctgccacaga aacataatcg tgtacaacag cactgctgtc atactgaagt caccggttac 1096561 ggcacaatac cccatcaatg gcggcgcagc tcctgggaag ctcccgacaa atgtgctcca 1096621 cacagacgtt cgtttcaccc ataccgtata gatgatcgca taaaaaataa aggcggccag 1096681 tccgagaaag gccgttaatg gattgaggga ataaagcatg gcaagacctg cgattcctaa 1096741 aacagagcca tatgttaaga tcatggctgg cggcattttc cctgtgaccg aggccctgct 1096801 gcgagttcgt gccatttttg cgtccatatg ccgatcaaaa tagttgttat agacagtgcc 1096861 ggaagccatc acaaacgcgg ttcccaacat tgctgttacc attgtcatca aaaaagccaa 1096921 gccggttaac gttttttctg cgcttgcaaa cgcgatccaa aacccgccga aggctgctat 1096981 cgagtttgat atgataatgc ccggctttgc aagtttgata aaatcgtaaa tggttacccg 1097041 gttcgaagct tttatgtatt ttgtttcaga tatggctgca gaatctcttg tattctccaa 1097101 aaatagacgc ctcccccaaa actgcatgct tttgttatcg taacaagagg gggacagaat 1097161 cacaattatt tcccatattt gtcatgatat tgtcattttt aaaacaaaaa aatggggagc 1097221 tggactgccc ccattttgat atgtggcgac tagtaaccgt aacctccccc atatcctccg 1097281 ccataacctc cgccgtaacc gtaccaaggg tagtaaggcg gtcgcgggcg cgggtagtaa 1097341 taaggcgggc gcggataaaa cgggtagaac ggataatacg gtcttggata ataataaggc 1097401 ggataaaatg gcggtctcgg acgcggataa taataaggct gtctttcatc ataaggggta 1097461 atttgttcaa atgactgttc attcaaaggg taatccaaga ggaaaacctc cctagctttt 1097521 tttattcctt ttaccatatt cctgatgctt aagttgggtg tatgtacatt catgaaattc 1097581 ggtttttttt atgatgaaat tccttaaaaa ggattgacat gaacttctaa atctcatagt 1097641 attacaaatg tgaaataaat gttactacaa tgttacaaaa acatttctaa atagatacag 1097701 ttccaactga tgaagagtaa atcgaaatgg ctacgaaaga aggagttttt gttgttggca 1097761 aaaagaatca aatggtttca tgtattaata gcagttgtat gtgtggtggg ccttatcggc 1097821 tttttccata atcattcatt gaaaaaagaa acggtcatga ataaagtaag aactgattct 1097881 caatatggga atgttgagat cgcaacgctt gtgaatgacg ggaaaacttt taattacgcg 1097941 gtaaactatc ctgttttcaa aaatgaaaaa atggattcgg cattaaaaag attcgcagaa 1098001 aaagaggttc gtcaatttca aaaggaaaca aaggacgttg accaagagca tacgacaaaa 1098061 cgcaacgaat taaatgttga ttataaaatt gtccattatg ccaaacagac agtggcgatt 1098121 gtatttaatg aatataaata catcggcggg gcacacgggc aaaccgtgaa aaaaacgttt 1098181 aactatgatt ttagtaaaca agcgtttctt tccattgatg atattttcaa agaggacgct 1098241 gactacttac ataagctttc gttaatcgct tatcacgagc tgaaaaagaa taaggacatt 1098301 gccgcggacg atgcactgtt aaaggaaggg acggctccga aaaaagaaaa tttcagccgc 1098361 tttgccatca aggaggatta tatcgaactt tactttgaca catatcaggt tgcagcaggc 1098421 tatcttggag agcaatcgat tgccattaag aaaagtcttt tgaaagacat tctgaaagaa 1098481 caatatattg ataaagcaaa aaataaaaat aaaatcaaag aacaaaagcc gaagcatgaa 1098541 gtgatttctt tacccaaaga ggaaacagtt gatccaaatc aaaaagtcat tgcgcttact 1098601 ttcgacgacg gcccgaatcc tgcgacaaca aatcagattc tagactcctt gaagaaatat 1098661 aagggtcatg ccacgttttt tgttttgggg agcagagttc aatattatcc ggaaacgcta 1098721 ataagaatgc tgaaagaagg aaatgaggtt gggaaccatt catggagcca tccgcttctc 1098781 acaaggcttt cagtgaaaga agcgttaaag cagatcaatg atacgcaaga catcattgaa 1098841 aaaataagcg gatatcgtcc gacgcttgta agacccccat acggcggcat taatgatgaa 1098901 ctgcggagtc aaatgaaaat ggatgttgcg ttatgggatg ttgacccgga agattggaaa 1098961 gaccgtaaca aaaaaacaat tgttgaccgt gtcatgaatc aggcgggaga tggaagaacc 1099021 attttgattc acgatattta ccgcacctct gctgatgcgg ccgatgaaat tataaaaaag 1099081 ctcaccgatc aaggctatca attggtgaca gtttctcagc ttgaagaggt taaaaaacaa 1099141 agagaagcga aataaattag aaaaggctgt ccgtacggac agcctttttt ctatttaata 1099201 agagcctgtg gtggcccaaa catttaagtt tggtcctgaa tacttgccga aagcgtaaga 1099261 agtccttgga tctaaatcat ataccatcgg tgtatagcaa gacttttggc cggccaccgc 1099321 ttttccattg ccgcctgcag aatcacaatt atatcttttt ccgtctgtgt tccgggtaat 1099381 ctccgcattt gcttcatagc cagacgtcaa tgtattattc atcgtgattt ttgcccaagc 1099441 cgttttacat gtactgctga atttaagctc gactactccg atgacttgat tgctggcatt 1099501 cactaagttt gaggattttt ttgtagagcc gctggacgca caatcattgt aataagggct 1099561 ttttccatcg taggcatggg tttccgcctt ggcgggtgca cctttgacgg caaaaacaaa 1099621 tactactgcg aataacacca atgaagcctt cataaacagt cttttcaatt tatgacctcc 1099681 ttaatatggc aaacaataaa tcatatggag gaacaatcaa aacatgcatg cttttttgtg 1099741 aacaataaag gcggccggga ggatggagtt cttggccgcc tctggtatga ggttatgctt 1099801 ttacatcaat ggtttgtccg agagttggat gttgaatcat ctttaaggtt tgatcggcat 1099861 tttgctgggc ggtgtccagc ctttttttcg ttaaagcaat atttacattc tgggcaaggg 1099921 atgcttgatg catcgcaacc gataaagcag gaatatccat ggttccacct cctatgcctt 1099981 acctatcggc gggtttgtat gattttacag tgaaaaatgg cttaatttct cttgttgacc 1100041 cttacgctgc ggcatatcgt atgtttttga caaggaggga atcaggatga atctagtaat 1100101 ggaaaagacc tttgagcaat acgaaaagct gttttcaatg gaagaacaga aaagagaaga 1100161 tgtatttcgg tatacgatga tgaggccgtt tgaaaagatg tggaccgcca tccaagttcc 1100221 gctgaaagcg aaggagccaa acggctatga tgtgatcatg gctgcgaaaa tgctgggcta 1100281 tttggatgtc cgtgatgctg aaagcggcca gaaagcacta caaatactga aagaatcaca 1100341 tgtttcagag acagctgaat ctgcacttcg gcaatgcata ttttttgctg agcgcgaaca 1100401 gctgcgggtg aatgcaaagg agatcaaatt cggcctttat atcgctgatc caaataagct 1100461 tcagctgcaa aaaggctact gcgggtttgg cgggataccg ggctttattc atgtatggat 1100521 taatccgaac agttataacc tgccaaggat tccttccatt attgctcatg agtttcatca 1100581 taatgtgcgg ttttcgtata tagattttca tcatggctct gtaagtgtcg gggattatct 1100641 tgtgattgaa ggattggcgg aatcattcgc cagagagctg tttggtacgg aacgattggg 1100701 cccttgggta actcgttttg atcatgaaga cttgcaatat tccattgatg tgattaatga 1100761 ggtgctggat gtgaaaggat tttcggaagt cagccgttat atgtttggtg atccaattgc 1100821 taacgaccaa ggctttaagc ctgcaggttt atcggctttt gcgggttatg cagttggcta 1100881 tcatgccgtt cagtcattta tgaatcaaca tcatatcacg ataagcgagg ccacacgttt 1100941 ggatgcgaag accattattt ctcaatgcgg tctgttttct acatgaaaaa agcgtcacat 1101001 acagcggcgc tttttgattc ccaaaaccag cagttctatg gcggcacagg cggcaattcc 1101061 gattgtatat gcttcgatat cgctccataa aaaaccgtac cctagtacaa gcccgccaag 1101121 agaagtatct ctaatctggt cgatccattc ggcatgatag agctggctga attcaatgac 1101181 aaaacagaaa gaaagactga taatgcccgt tatcattgtc ttcagcttcc gaaatagaaa 1101241 tccgcatccc gtgaagatca tggcggccca caacgagtct cccagataag tattgagggt 1101301 atcaggaaga acactggaga atgctctgga tccaagcccc agcccaatga tcagtatggt 1101361 gaaaactgca tatatccaac gatttcgctt cattgcgaat tgataccccg tctctgcttc 1101421 atctccctgt attgtaagga atatagcttt tatttgtcca ctaaaaaagc ggctgaatag 1101481 ccgcgtaggg tgtttatttt gcttttaggt ttacatggtc ggctgtctga tccgtgccta 1101541 ttacaaaatg gagttcatag cggcctgtat catatacata atcgatttca tcggtaaacg 1101601 ggacggttaa cacccgattt actggtccta attgcttctg cagcacttcc ggcgtaactc 1101661 cgcctaaatt cagctgccgt tccacaccgg ttccaaagta gcggatttct gaaattgtca 1101721 tgtctttatg ataggaaaat ccgtagcccg gctgtcccat attccagtga tataaatcaa 1101781 atcgattgtc tcccccgact ggtctttccg gttccccaaa cgcagcgtgg acatcccctt 1101841 ttgtgctttt gttaatggta aggccttgcg cctgctgagg catttcccct ttataggcgg 1101901 tgttatagag gtttttgaca agctcagcgg ctgattgatt cgtgttttct gagagtgtgt 1101961 ttgtttgagc tgcggccttt gccggtgctg aaaaggacgc agccccaaag ccggtaaaac 1102021 agcttgttac tgctgctgcc gcggttatag cagacattgt ctttttcatg ttaatccctc 1102081 ctaattgatc taccattccg tttccccgtg tttttgcaac gaaacatgtg agtgcgcttt 1102141 gtatgtttta ttgagttgtt gtaagggaac tgaaataggt aattcggtat ataaagcaag 1102201 aaaggggaat ggagatggct ggcaagaaaa caatcacaat aaacggcgtt gaaatggaag 1102261 cgtccgagga acagacggtg ctgcagcttt tgaataacag ctcgattgaa gtgccgcaag 1102321 tttgctatca tccaagctta gggccgattg agacatgtga tacgtgcatc gtcagcatca 1102381 atggtgagct gaagaggtcg tgctccgctg aattaaagga tggggatgtc attgatacgc 1102441 tctcacctga cgtgaaaaaa gcgcaggtca tcgggatgga caagatttta tataatcatg 1102501 agctttattg tacagtttgc gattacaaca atgggggatg cgaaatacat aatacggtga 1102561 aggaaatgaa aatcaatcac caaagcattc cgtttgatca caagccatac cataaggatg 1102621 aatcccatcc gttttatcgg tatgatccag atcaatgtat attgtgcgga cgctgtgttg 1102681 aggcatgcca agacgttcag gtaactgaaa cgctgaccat tgactgggag cggaaacgcc 1102741 cgcgcgtcat ttgggataac gacgtgccga tcaatgagtc gtcatgtgtg tcatgcggcc 1102801 attgttcaac ggtctgtccg tgcaacgcga tgatggaaaa aggaatggaa ggggaagccg 1102861 gatatttaac aggcatcaat aacgaaacgc tgcgaccgat gatcgagatc acgaaaggcg 1102921 tagagacagg ctacggctcg attctcgcga tttctgatat ggaatcggcc atgcgtgatg 1102981 aacgaatcaa aaaaacgaaa accgtctgca cgtattgcgg cgtcggctgc agctttgatg 1103041 tctggacaaa gggcagagac attctgaaag tagagccgca ggaggaagcg cctgccaacg 1103101 gcatttctac ttgtgtgaaa ggcaagttcg gctgggattt cgttaacagc gaagaacgcc 1103161 tgacaaagcc gctgatccgt gaaggcgatc atttccgtga agcagagtgg gaggaggcgt 1103221 tattgctgat cgccagcaag ttcactgaat taaaagaggc gtttggcccg gattctctcg 1103281 cttttattac atcttctaaa tgtacaaatg aagaatccta tcttatgcaa aagctggcca 1103341 gaggggtcat tggcacaaat aatgtggaca actgctctcg ctattgccaa tctcctgcga 1103401 ctgccggcct gttccggaca gtcggctatg gcggtgattc aggatcaatt acagatatcg 1103461 cgcaagcgga ccttgttttg attatcggtt cgaacacgtc tgagtcgcat ccagtcttat 1103521 ccactcggat taaacgggct cataagctga gagggcagaa agtgatcgtc gcggatatca 1103581 gaaagcacga aatggcagag cgctcagatt tatttgtcca gccgcgtgcc ggatcggata 1103641 tcgtctggct gaatgcgatc gccaaatatt taatagaaaa cggcaaggcc gatgaacgat 1103701 ttttgagaga aagagtgaac ggacgggatg aatatgtaaa aagcctcgcg ccgtacacac 1103761 ttgaatatgc tgaggagaaa accgggattg atcaagaaac ccttatccaa atggcagaga 1103821 tgatcgggca agctgacagt gtgtgcgcat tgtgggcgat gggcgtgaca cagcatattg 1103881 gaggaagcga cacgagcacg gcgatctcta atctgctgct tgtgacagga aactacggaa 1103941 aaccgggagc aggttcttac ccattgcgcg gccataacaa cgtgcaggga gcaagtgact 1104001 ttgggagtat gcctgacaga ctaccgggct atgaaaaagt gacggacgaa caagtccgcc 1104061 aaaaatacga gcgtgtgtgg ggtgtgccgc tgccgaagga gccgggtatg accaaccacg 1104121 aaatgattga aaaaatccat tccggacagt tgaaagcgat gtatgtaaaa ggtgaagaaa 1104181 tgggccttgt cgactccaat atcaatcatg tacacgctgc atatgaaaag cttgatttct 1104241 ttgtggtgca ggacattttc ctttcacgta cagcggagtt tgctgatgtg gttcttcctg 1104301 cgagcccgag ccttgaaaaa gaaggaacgt ttacaaacac agaacgccgg attcagcgtt 1104361 tgtatcaggt atttgaaccg ctgggtgaat caaagccgga ttggcagatt attatggagg 1104421 ttgccaataa gcttggcgcc ggctggctct atgagcatcc tgcagacatt atggaggaag 1104481 cagccaagct gtcgccgatt tatgccggtg tcacctatga acgtcttgag ggctataatt 1104541 ccctgcaatg gcctgtaaac gctgatggaa aggattcgcc tttactcttt acagagcgct 1104601 tccctttccc agacggcaag gccattctct accctgtcca gtggacagag cctaaggaat 1104661 tcggtgagga atatgatatc catgtcaaca atgggcggct cttggagcac ttccacgaag 1104721 ggaacctgac ttacaaatca aaagggattt cggagaaaac accggaagtg ttcttagaaa 1104781 tttctcctga gcttgcggca gaacgaggga ttcaggacgg aaccctcgtc agactcacat 1104841 cgcctttcgg aaatgtcaaa gtgaagtgcc tgattactga tcgagtcaaa gggaaggaag 1104901 tatatctgcc aatgaacgat tcaggggaag cggcgatcaa cctgttaaca ggcagccatg 1104961 ccgataagga taccgatacg cctgcttaca aagaaacatc ggccaagatg gaaattttga 1105021 agcacgacgg aatcagcccg ctgcctaaga tcaaccaccg caacggcaat ccgcagccgc 1105081 aaatcggtgt gcaggttcat aagaaatggg cgcggaagga ttatattttc cctggtgacg 1105141 ctgtgaaaag ggggatgggc cataatggct aaagcgatta aacgaatcca aaaaatcgag 1105201 gtaacagaag aggatcagcg aaagcgtgat ttgcgggaaa ttgaagatgc tctaattgac 1105261 cacaaagaag cgattctcga aacattgcat atgctgggcc atatgaacga gcgcggggtc 1105321 ctgccgttgc tccgcggcct ttttggtcaa ggggataaag ttcttgatat cctggtgaaa 1105381 aaggcagata cagaggaaac agccaatacg ctgaaaaatc tgcttcttct gtttggaaca 1105441 ctcggcatgc tggacgtgaa gcagctggag cctctcattt tgaaagtgaa tgcgggtgtg 1105501 gcaagcgctg tagagcagaa aaacagtgaa gaaaagacag gttattttga tattatccgc 1105561 tcgctaaaag acccggaaat caacaaatca attacactgc tcttttcctt tttaaaagga 1105621 atgggacaag atacaaagga gctggaacgc acgacgcagc ctccggaaca ccaaaaacat 1105681 catcaggaac cccgagagaa aagaggaatg aataagcgag attgacctcc cacccgagcg 1105741 gcttcagcca gctcgggttt tttgatgaaa aggtctaatg gactagtaaa aaatattcaa 1105801 atactaggaa gaagtaagat tgtgatgaat gagatagaaa taatcgttac tttcttacct 1105861 gttaagaaaa gggaaaatct gattataata gaaatcgatt actttagatg ggggaacaat 1105921 catgaaaaaa gtcttattac tattatttgt cttgacgatc gggttagcgc tttctgcgtg 1105981 cagccaatcg agcgatgcgt cagagaagga aaaaccgaaa gagaaaaaat cgcaagaaga 1106041 gcttgaaaag gaacttgata aggaattgaa aaaaggcggt gagccgaaga ccaaaaaaga 1106101 tgatcaaata cataaaatag gagaaacatt taaagcagga catacgaatt ttacagtgaa 1106161 taaagttgat agagtgcaaa aaggtgaata tatgaatgtt ggcggagctg taaatgagga 1106221 gacaaaaaca ataaaagatg atgaggaacg gcttattata gaagttacga tggaaaatat 1106281 aggggaagat tcaataagct acaattttat cgggtttgat ttaagagata agaatgatca 1106341 atcagtgcgg cctgtttttt ctatagaaga gaagggcaga atccttatgg gaggaacact 1106401 agtatcgggg aaaaaggtta caggtgtact cagttatgtc atccctaaag gagaacagaa 1106461 acattacaca ctggtatata atccgttttt agctgataca aatagcagta atacagaaga 1106521 gagagtaaag gacgatattg attacttggt gaagttagat tagatgctaa tttacagttg 1106581 cacgtttttc atctgtggaa aacgtgcatt ttttatagcg aaacttgact tgaaaggatg 1106641 agtgataaaa gtgcaaacca aatggctgga acgggcacag cggattcggg cgatcgccca 1106701 agcggggctt gctttttcca aggatgtgta cgacagggag aggtacgaag agctaatgaa 1106761 gcttagcgcg gaaatgatgg cggattactc ggagaaggac attgaagtta tcactgattt 1106821 atggcaaggc gagaagggct atccaacacc gaaagcggat gttcgcggcg ctgtattcag 1106881 agagaatcag attttgcttg tccgggagaa gcatgatgag ctgtggtcgc tgccgggcgg 1106941 attttgcgag attggtttat cgccggctga aaacgttgtc aaggaaatca aagaagagtc 1107001 ggggtacgat acagagccgt ctcgattgct ggccgtgcta gacagccata aacactctca 1107061 tccccctcag ccttatcact attataaaat cttcatcgca tgcagcatga cggacgggca 1107121 gggggaaaca gggatcgaga cgaatcatgc cgcttttttt ccggaagaca gactcccgcc 1107181 gctttctcct aaacgaaaca caccctcaca gcttagcatg ctgtttgact ttttgcgcca 1107241 tccggacaag aaaacgatat ttgactaaaa aagaaagagc ctgtgggctc tttctttttt 1107301 ataatgtaat gtgtttttcg ttggcgagtt tcagaagggt caaaatagaa tcggcttgtt 1107361 tatggccgag tttttgcttt aatttgtttt cttcaactaa tcggctgcca taaattttga 1107421 cggaggcttt gtcgacgaca gtatgccagt tttcctgttt ttttccctca acaagcggtt 1107481 tttcatgtct ctcagaaaaa gagaacacaa agagtacgaa tgcaagtgaa agtaggattc 1107541 cgacaacttg ttttttgtaa tcagtctgtg ctgccacgtt gttctctcct tcacctttta 1107601 ccttctattt aatcatagaa ccaaattatt ttacataatg ggaaagtcat ttttggagtt 1107661 agtgcatttg gttgaaaaca gagacgtttt ttgagcggag cggtgcaatt gaatccatat 1107721 tggatttgcg tgcttatgcc taaggtcacg ttgtgagcca aaacagcagt gcagaataga 1107781 aaaaaattga aagattatgg taagatgaac gaaattcgag ggggaatata tgatgcctgc 1107841 atcgaacatc gtgatcgcct gcctgctgtt atcaatttaa ttatttgtgg tagtccctct 1107901 ctttttcgaa agcgggaggt gaagtggaac attaattgct gaattctttc aaggggagtg 1107961 accgtacatg aatgtgttaa accgccggca agccttgcag cgagcgctgc tcaatgggaa 1108021 aaacaaacag gatgcgtatc atccgtttcc atggtatgaa tcgatgagaa aggatgcgcc 1108081 tgtttccttt gatgaagaaa accaagtgtg gagcgttttt ctttatgatg atgtcaaaaa 1108141 agttgttggg gataaagagt tgttttccag ttgcatgccg cagcagacaa gctctattgg 1108201 aaattccatc attaacatgg acccgccgaa gcatacaaaa atccgttcag tcgtgaacaa 1108261 agcctttact ccgcgcgtga tgaagcaatg ggaaccgaga attcaagaaa tcacagatga 1108321 actgattcaa aaatttcagg ggcgcagtga gtttgacctt gttcacgatt tttcataccc 1108381 gcttccggtt attgtgatat ctgagctgct gggagtgcct tcagcgcata tggaacagtt 1108441 taaagcatgg tctgatcttc tggtcagtac accgaaggat aaaagtgaag aagctgaaaa 1108501 agcctttttg gaagaacgag ataagtgtga ggaagaactg gccgcgtttt ttgccggcat 1108561 catagaagaa aagcgaaaca aaccggaaca ggatattatt tctattttag tggaagcgga 1108621 agaaacaggc gagaagctgt ccggtgaaga gctgattccg ttttgcacgc tgctgctggt 1108681 ggccggaaat gaaaccacta caaacctgat ttcaaatgcg atgtacagca tattagaaac 1108741 gccaggcgtt tacgaggaac tgcgcagcca tcctgaactg atgcctcagg cagtggagga 1108801 agccttgcgt ttcagagcgc cggccccggt tttgaggcgc attgccaagc gggatacgga 1108861 gatcgggggg cacctgatta aagaaggtga tatggttttg gcgtttgtgg catcggcaaa 1108921 tcgtgatgaa gcaaagtttg acagaccgca catgtttgat atccgccgcc atcccaatcc 1108981 gcatattgcg tttggccacg gcatccattt ttgccttggg gccccgcttg cccgtcttga 1109041 agcaaatatc gcgttaacgt ctttgatttc tgcttttcct catatggagt gcgtcagtat 1109101 cactccgatt gaaaacagtg tgatatacgg attaaagagc ttccgtgtga aaatgtaata 1109161 gataaggaga ctggagattc atgaaaaagt accatatttc gatgatcaat atcccggcgt 1109221 acggacatgt caatcctacg cttgctttag tagagaagct ttgtgagaaa gggcaccgtg 1109281 tcacgtacgc gacgactgag gagtttgcgc ccgctgttca gcaagccggt ggagaagcat 1109341 tgatctatca tacatccttg aatattgatc ctaagcaaat cagggagatg atggaaaaga 1109401 atgacgcgcc cctcagcctt ttgaaagaat cactcagcat tctgccgcag cttgaggagt 1109461 tatataagga tgatcagcct gatctgatca tctatgactt tgttgcgctg gctggtaaat 1109521 tgtttgctga aaagcttaat gttccggtca ttaagctctg ttcgtcatat gcccaaaatg 1109581 aatcctttca gttaggaaat gaagacatgc tgaaaaaaat aagagaagca gaggctgaat 1109641 ttaaagccta cttggagcaa gagaagttgc cggctgtttc atttgaacag ttagctgtgc 1109701 cggaagcatt aaatattgtc tttatgccga agtcttttca gattcagcat gagacgttcg 1109761 atgaccgttt ctgttttgtc ggcccctctc tcggagaacg gaaggaaaaa gaaagcctgt 1109821 tgattgacaa ggatgatcgc ccgcttatgc tgatttcttt gggtacggcg tttaacgcat 1109881 ggccggaatt ttacaagatg tgcatcaagg catttcggga ttcttcatgg caagtgatca 1109941 tgtcggttgg gaaaacgatt gatccagaaa gcttggagga tattcctgct aactttacca 1110001 ttcgccaaag tgtgccgcag cttgaggtgt tagagaaagc tgatttgttc atctctcatg 1110061 gcgggatgaa cagtacgatg gaagcgatga acgcaggtgt gccgcttgtc gtcattccgc 1110121 aaatgtatga gcaggagctc actgcaaatc gggttgatga attaggcctt ggcgtttatt 1110181 tgccgaaaga ggaagtgact gtttccagcc tgcaggaagc ggttcaggct gtatccagtg 1110241 atcaagagct gctcagccgc gtcaagaata tgcaaaagga tgtaaaagaa gctggcggag 1110301 cggagcgtgc ggcagctgag attgaagcgt ttatgaaaaa atccgctgtc ccgcagtaaa 1110361 aacataaaaa ccgaaatcaa tttgatttcg gttttctgtt taaatatttt ttttcatccc 1110421 gcatctccgg cattctctaa gaaattttcc gccttttaca gagcttttga acagtgtgta 1110481 atcacagttg tcgcagcgcc cgctgcgggc atccggatat tcattgaatt cgtaaacaat 1110541 cgatgtatcg tagccttttg tttcatattc ttcttttttg gtttccatgt cgatcctccg 1110601 ttacaagacg tgtctgctgt ttatcttaca gcaagcttcc ggcgtattca atggatttta 1110661 ggaggttggg tttatcttga tttctccctt ggtttgcgcc aaaatagctt tattaagctt 1110721 atatacataa aaagcctatg caaagaggag aggaaacggg tatgggaaaa gggttacttg 1110781 gaaaacgcgt ggcaatcggt ggctcacgaa aaacggaaga aattagtaca atcattgaaa 1110841 aacagggcgg aatacctgtc atccggcctc tccaaggtac agtttactta gcagagaagc 1110901 aggtggagcc ggatttgcgg acgtttgcgg aagaaaaagc tgactgggtc attttcacga 1110961 caggcatcgg gttggagact cttgtcgata tggcagagaa aattggactg aaagatgagt 1111021 ttctgcaggc cattcgccaa gcgaaagcgg catgccgggg atacaaaacg ctgtctgcgc 1111081 tgaaaaagct tggaatcaca ccggaagctt cggatgaaga cgggacaaca agaggcttaa 1111141 tccgttcctt ggagcctcac gacttttcag gaaaaacagt catggtgcag cttcatggcg 1111201 aaaaagcgcc ggctctcatg gcatttcttg aagaaaaagg cgcgtctgtc ctgccgattc 1111261 tgccttatca gcacatcccg ccggaggagg aaacggtgga gcggttatgc cgagagctga 1111321 tgaacgatga ggtcgatgcc gtttgtttta caacggccat tcaggttcgt tccctgtttg 1111381 attttgccaa ggggcgaggt tatatcaatg aagtgaagaa ggtattcgaa gaacgcgcca 1111441 tcgcagctgc tgtcggaaaa gtgactgctg aagcactgcg ggaagagggc attacgagac 1111501 tgcttgcgcc agagattgag cggatgggtg cgatgattgt tgagctggcc aagtattatg 1111561 aagaaaagga ataacaagta caaaaagccg cttttccctc ggaaagcggc ttttgtctgt 1111621 cattcatttt gcttcagctg ctgatgaacg gtgaataatg atgggtatgt cagcacgctt 1111681 aagattacac aagtcagcgc ggctgaggcc atcgttgtaa acacgattaa gagttgaaag 1111741 cgtactgcct gaatcgggtc cgcgccggct agaatctggc cagtcatcat gccgggaagc 1111801 tggacaagac ccagtgtttt ctggctttcg agcgtcggga tcatactcat tttcatcgct 1111861 gaggtaagaa tgcgctgtat ggattgcttc ggtgtgccgc caagtgacaa tattaattga 1111921 atttcttctt tgcgaacgcc gacttctgag ttaagccggt ttagaaacaa acttgagagc 1111981 accatcgaat ttccgatgac catcccgctg atcggaatga catatcgtgc cgtaagcgga 1112041 atgatatgaa gagacagcag aattccctgc gtcacaattt ctacgattgc taacgcggca 1112101 aacaccctcc aaaacgaacc gatagtattt ttctttcgct tgatgacatt ttgcgccgcc 1112161 accgcgagca ttaacagcac catcagcagg ataaaaacag ggtggtctcc gcgaaaaatc 1112221 agcgacaaaa cataaccgat gataagcagc tgcaccgcgg cccggatggt ggcgatgatc 1112281 atgtcttttt ctacaccggc tttaaaggat tttgataaaa acaaggcgat caaaacaaag 1112341 atcatcgtta aagagagaga aaggtaatcc attaccgagt gcctcccttc aaaaattctt 1112401 tcgctgcttc atgctgcgga gcggagaaaa atgtgtcggt ttcagcgatt tcaagcagcc 1112461 ggccatctgc cataaaccaa atggtatcgg ctattcgttt tgcctgctcc atattatgag 1112521 tgacccacat gactgtccat tttttctctt gatgctgacg tttgatcagt tcttcaatct 1112581 caagagcaga gaccgggtcc aaggccgatg tgatttcgtc caacaataga atggaggaag 1112641 gatttgagag cgttctggcc agtgacagtc tttgccgctg cccgcccgat aagtctctgg 1112701 cgcttctgtc taacaactct ggcggcagcc ctgcaagcga agccagcttt tcaggagagt 1112761 acagctggga ttgatgcagc ctttgtacaa gacttaaatt gtcacgcact gtcccgtcga 1112821 gcacgggagc cgattgaaac gcgagggctg ccgttcgcct cagctcattg acattccatt 1112881 ctctgacttc ctttccgtat atgttgactt cgccgctgtc aggcgttctc attaaattac 1112941 acatagaaag gagggtgctt ttgcctgagc cggaagggcc taaaacggct acgattgcac 1113001 cctgttgaat gtctccggtg acatcctgca gcacatcata ggtttgtcca tcttgtttat 1113061 agctttttct gactgatctg aaggagatgg ctggtatgtt ttgtgtttga tcgtttgctt 1113121 ccattacaat aatcaccttt caatataagt aggctgacat tatatttaac tataacgtga 1113181 aacagattcc ttttggtagc acaaataaag gagaacaggc tttcacccat tctcctgcag 1113241 atgctacgca gtcagatttg actgtgcttt ctttttcggt tttctcggct gtgaagcgaa 1113301 ggtatgtaac atcatccccg ctattataat gaacaaaccg gcaaatgata atagagatgg 1113361 gaaaacgcct gacagcagaa caatttcacc aagcagcgcg aaaatcactt caccggattg 1113421 agtggcttca acagctgcga gtttttgcgg attgtctctt accatatcag tggcccagaa 1113481 aaataaaacc gtcgcaatga tgcctgagct gacggcaacg ataaaggatt gaacggtttg 1113541 acttgctgtt ggaaggccat ctgaccacca gccgtaagct gctaatataa gccagaatgg 1113601 aaggcttgcc aatgtcattc caagcacgcg ctgaaatgta tcaagccggc ctccgtattc 1113661 ttcgagcatt cttcggtttc ctaacggata ggcaaaagcc gcaatgacaa ccggcagcac 1113721 actgaaaagc agcatcctcc cagaaagcga ttctgcatgc tgaagctgaa tcagagccgc 1113781 tccaatcagg atgatcacag aagtgccaag tgaaaccagg ggaatctttt ggcgaatgag 1113841 ctgcggaccg cccggcatat cttgtttgac ataaaacaaa ggagataaga gcaccccggc 1113901 tacaattgta atttgccagg ttccagctat gagccacccc ggaccgtatg cagccgcaaa 1113961 tgtaatcggt gcgtaaaaaa gcacgaaacc gacgaagctc catttgatcc aataaaacgg 1114021 ctttttcctc atttctagta agagaggcgt gaatgtccct ctcatgatga caatcaaaca 1114081 taaaaatggc accataaaaa taaagcgcag cgaagagctc caaagccagc tgcctcctga 1114141 taactccatc gctctgttta atataaaggt aacggcgaaa aagagtgaag ccaatattcc 1114201 gataacgata gctttcatga tatccctcat tctggcatta tttttttata ctatactatt 1114261 cggtatcatg cagatcaatg gaatcatgag aaaaacatca tgtttggcga accgctatat 1114321 gtggaagaca aaaaagggag gtgaaattga tggaaagaga gacacagaca tacttctttc 1114381 cggatgacgg caggattccg aatcaccctg attttccgct cgtggtgtat caaaacgcgc 1114441 ttaaggacac cggactggca gagcggatcg tcacccggca tggctggtca aacagctggt 1114501 cagggagtgt ttttccatac catcattatc acagcaatac gcatgaagtc ctgattgccc 1114561 ttaggagaga ggctgtgatt cagtttgggg gagaaaaagg ggctgccatc cctttcaaat 1114621 caggcgacgc agtcgtgatt ccagccggag tcggacataa aaagctcagc tcaagccccg 1114681 attttactgt ccttggcgcc tatcccggtg gcgttcagta cgatatgaag acggggaagc 1114741 cgaatgagcg ggaggaagcg gtcaaacaga ttaagcaggc ggcgttgccg gcgaatgatc 1114801 cgatcacagg aaaaagagag cctctattgg aaatatgggt aaagtgaagg ggagaaattg 1114861 ctggattgtc aataactagt gccgcagaaa cgatatgaca tgagctccat ataaattaat 1114921 ttcataatcg aagcaattca cgttcaaatt ttgttcaaaa agtgttatca tatagaaggt 1114981 aatcgaattg gagttttttg tgtttgctat tttcagagag agtaaaggat tttgacttat 1115041 tcaattgttt atttttagat aaaaataata ctgaatatgg caagatgaaa aactgggtag 1115101 taaacattta tttttgtaaa tgattgtgca tgaattcaca atccttattc ttatgcctta 1115161 aaagcgtgag acagggagag gcactaccct ttccaaaaaa atcagcaaac tgcttatagt 1115221 aaaggagaat tggatatgcc agaaacaatc gatcaaacaa atgcgtctgt cagccaaagc 1115281 cagcaagatc ttattgatca gctattaaag ccagaagttc aagaatcatt gactgtttta 1115341 gttgaccagc ttccgaagct gactgagtta gtgaatattt taacgaagtc ttatgatttc 1115401 gctcagtctg tagcgactga cgaagtgtta aagagcgaca cagtcggtgc gatcactgaa 1115461 attctcgagc ctgtaaaaga aacagcgaaa gaagtagctg cgactgcgat cgaagcaaaa 1115521 gaccgcgcgg aagcaagcaa cgaaacaatt ggacttttcg gccttcttcg catgctgaaa 1115581 gatcctcaag ctcaaaagct gttccgtttt gctaacagct accttgaagt catgaacgaa 1115641 cgcgaaaacc aaaaataatc tcagattcaa attgatataa aggacggagg atatacgatg 1115701 tcaaaacata ttgtcattct aggcgctggt tatggcggag ttctttctgc tctaacagtt 1115761 cgcaaacatt acacaaaaga acaagcacgc gtgacagtgg taaacaaata cccaactcac 1115821 caaatcatta cggaattaca ccgccttgct gcaggcaacg tgtctgaaaa agcggttgca 1115881 atgccattag aaaaactttt caaaggcaaa gacattgatc ttaaaattgc ggaagtaagc 1115941 tctttctctg ttgataaaaa agaagttgcg cttgctgacg gttctacatt aacttacgat 1116001 gcgcttgttg taggtcttgg ttctgtaacg gcttacttcg gcatcccagg tcttgaagaa 1116061 aacagcatgg tattgaaatc tgctgccgat gcgaacaaag tcttccaaca tgttgaagat 1116121 cgtgtgcgcg agtactctaa aacgaaaaac gaagcagatg caacaatcct tatcggcgga 1116181 ggcggcttaa caggtgttga gcttgttggt gagcttgctg acatcatgcc gaaccttgcg 1116241 aaaaaatacg gcgtagacca taaagaaatc aaattgaaac ttgttgaagc aggtccgaag 1116301 atccttcctg ttcttccgga tgatcttatc gagcgtgcga ctgcaagcct tgaaaaacgc 1116361 ggcgttgagt tcttaacagg tcttcctgtt acaaatgtag aaggaaacgt aatcgatctg 1116421 aaagacggat ctaaagttgt tgccaacaca tttgtttgga ctggcggcgt acaaggtaac 1116481 ccattagtcg gtgaatcagg cctagaagtg aaccgcggac gcgcgactgt aaatgacttc 1116541 ctgcaatcta catctcatga agatgtattc gttgctggag acagcgcagt ttacttcggt 1116601 ccagacggcc gtccataccc gccaactgca caaatcgcat ggcaaatggg tgagctgatc 1116661 ggttacaacc tattcgctta cctagaaggc aaaacgcttg aaacattcaa gccagtaaac 1116721 tctggtacac ttgcaagcct tggacgcaaa gacgcggttg ccatcattgg tgctaattct 1116781 acaccgctta aaggtcttcc tgcttccttg atgaaagaag caagtaatgt acgatatttg 1116841 acacatatta aaggactttt cagcctggct tactaatcct tttaatgaat ctggcattgc 1116901 caaaagcatt cctttccgag tgctttctgg caatgtcttt ttttatgttt atgacagcgt 1116961 taacatttca ttttcaaaaa agagattgat cccaaaggaa tataaaggta aaataaaaac 1117021 aaatcaaaat gttaacgtta acattttgaa atagaatgaa agacggtgag gacatggaac 1117081 ccttcatggg caaaaacttt ttattgaaaa atgaaaccgc tgtcagcctc tatcacaatt 1117141 atgcgaaaga catgccaatt attgattacc actgccactt aagtccgaaa gaaatctatg 1117201 aaaataagac atttcaaaac atcacggaag cctggctgta tggtgaccat tataaatggc 1117261 gcatcatgag agccaatgga attgaggaga catacattac cggagatgcg cctgatgagg 1117321 agaaatttat ggcttgggcg aaaaccgtgc cgatggcgat tggcaacccg ctctacaact 1117381 ggactcactt agaattgcag cgtttttttg gcatttacga gattttaaac gagaagtccg 1117441 ggtcggctat atggaaacag acaaataaac tgctcaaagg ggaaggcttc ggggcaaggg 1117501 atttaatcgt gaaatcaaat gtaaaggtcg tgtgcaccac agatgaccct gttgattctc 1117561 ttgaatacca tttattgtta aaagaagaca aagactttcc tgtcagtgtg ctgcctggat 1117621 ttcggccgga taaaggactt gagatcaatc gtgaaggctt tcctgagtgg gtgcaggcgc 1117681 ttgaagatgc cgctgccata tcgattacaa cctatgatga gtttttaaag gcgttggaaa 1117741 aacgagtgcg attcttccac tcagccggcg gcagagtttc tgatcacgcg atagatacaa 1117801 tggtatttgc cgaaacaaca aaagaagaag ctggacggat tttttctgac agattacaag 1117861 gaacagaggt ttcttgtgaa gatgagaaga aatttaagac atatacgctt cagtttcttt 1117921 gcggtttgta tgcggagctc gattgggcga tgcagtttca tatcaacgct ttaagaaaca 1117981 cgaatacaaa aatgatgaaa aggctcggac ctgatacagg gtatgattca atgaacgatg 1118041 aagaaattgc taagccttta tacaagctgc tgaactcagt tgagatgaag aaccagctgc 1118101 cgaaaacgat tttatattca ctgaatccaa atgataacta tgtcatcgcc agcatgatca 1118161 acagttttca ggacggtatt accccgggaa aaatacaatt cggcacagcc tggtggttta 1118221 acgatactaa agacggaatg ctcgaccaaa tgaaagcgtt atcaaatgtt ggccttttca 1118281 gccgttttat cggcatgctc accgattcca gaagctttct ttcgtatacg cgccacgaat 1118341 atttcaggcg gatcgtctgc aatttgattg gagaatgggt ggaaaacggc gaagtgccgc 1118401 gcgatatgga gcttctggga agcatcgttc aggggatttg ctatgacaat gcgaaacact 1118461 actttcaatt tcaagaagag aaagcaaacg tgtaacaaag tgtccgctca gtatcgctga 1118521 gcggatcact atccgaaaat tcttaagaca cagaggtgga acatgcgaac tgaactggca 1118581 aataaggttg tgtcggtcga aacggaaaaa aggctttcat tgaaagagaa aatgtcctat 1118641 ggctttggtg attttggcaa cggttttatg tttgatctcg gccagattta tttattgaag 1118701 tatttcactg atgtagcggg aatccccgct gcgatggccg gcggcatttt tttagtcagt 1118761 aagctgtttg cagcgataac agatccaatt gtcggctcat caatcgatta tcgcaaaaac 1118821 atcggcaaac gggggaaatt caggccttat ctattaatcg gcagcatcgt gcttgcggtg 1118881 cttactgttc ttatttttct gtctcccaat gtatcaacga ccggaaaact gatatatgca 1118941 tatgcatcct atatgatttg gggcatcggc tattcgtttg tgaatattcc gtacggctca 1119001 ttaggggcag cgatgactca aaattctgag gaccggacct ccatttcgac gttccgccaa 1119061 atcggatcac ttggcgcctt gtttatcaca agtgtggccg tgatgccgct gctcgtcaag 1119121 tttgataatc cgaaggtcgg ctacccggtg gtcatgggct tgttcgccgc gctcggtgtg 1119181 ttttggtttt atatttgcta ccgcaactgc aaagagcgca ttatcatatc ggaagcaccc 1119241 aaagaaaaat taacactctc atctgtcgtc aaaacattta ttacaaataa accgctgtta 1119301 acccttgtcc tgatgacgat tttttcaatt tccgcataca acattaaatc cgccatgctc 1119361 gtctatttcg cacaatataa cttgggcaat gttgaattaa tggcttatat gaacttcatc 1119421 attattggtt cttccttttt gggcgtcgta ttccttccaa agctcgtcaa gatgtttgga 1119481 aagaaacgaa cggcaatgat cggctttggc atcagtgtgg ccgcggatct gatcaacttt 1119541 atgcttccat ctaacgttta tgtgtttaca attctcgcca gtatcgcctt tatcggaatc 1119601 agtatcccaa atggcatcac gtgggctctt gtctccgata ttatcgacta tggcgaatgg 1119661 aaatccggtg aacggaagga agcaacgaca tattcacttt tcaatttctc aagaaagctt 1119721 gctcaatctt tgtctggctt tctctcgggg atcggtttgg ggattatcgg ctatgtgccg 1119781 aatgcagtcc agacagcaca ggcgctgatt ggcatcaaag cgctgcttct tctgtatccg 1119841 gccattgctt tggcattagc gatgttcatt atcggctttc tttataaact cacagaccag 1119901 cagcatgctc agatcgttca ggatcttcat caaaagagct gacaatataa tataaagaat 1119961 atttaaaata atttgtaaat aaaatgtgtt tgtaggggtt tcgcttggag agtgcccaaa 1120021 aaactgaaaa ggaaggaggc acttgcttga aaacgataac aattgcagct gaagaagcaa 1120081 aggaactcgt ttggcaaaag ctggacggtg ccggtttgaa tgaacgagat gctgaaaaag 1120141 tggcagatgt tctcgtgcac gctgatttgc gcaatgtaca ttcgcatggc gtgctgcaca 1120201 cagaacacta tgtgaacagg cttttagcgg gagggatcaa tcctggggca cagcctgttt 1120261 ttaaagagac ggggcctgtg accggggtgc ttgacggaga cgatggtttc ggtcatgtga 1120321 attgcgacat ggcgatggac catgcaattg acatggcgaa gaaaaaagga gtcggcatgg 1120381 tcacggccgt aaacagcagc cattgcggag cgctaagcta ttttgtgcaa aaagcggctg 1120441 acgaaaagct gatcggaatg gcaatgacgc atacagacag tatcgttgtc ccatttgggg 1120501 ggaggactcc tattttaggg acaaatccga ttgcttacgg agttccggct aagcataaaa 1120561 aaccgtttat cctagatatg gcgacatcca aagtggcttt tgggaagatt ctgcaggccc 1120621 gtgaagaggg caaagaaatt cctgaaggat ggggagtcga tgaaaacgga gaagcagtaa 1120681 ctgatcctga caaggtcgtc tcactttcaa cattcggggg cccgaaaggc tatggactat 1120741 cgattgtagt ggatgtgttt tccggattgc tggcgggcgc ggcttttggc cctcatattg 1120801 ccaaaatgta caacggcctt gatcaaaaaa gaaagctggg gcattacgtt tgcgcgatca 1120861 atccatcctt ttttactgac tgggatacgt ttttagagca gatggatgcc atgattgatg 1120921 aactgcagca atcaccgccg gctgttggat tcgaaagagt gtatgtgccc ggcgagatcg 1120981 agcagctgca tgaagaaaga aataagaaaa acggaatttc tatcgcccgg agcgtgtatg 1121041 aattcttaaa aagcaggtga gtaaaatgaa agcggttcaa gtgcgaaaag cgtatgatct 1121101 ggtgacagcg gaggtgaaga agccagttct ttcaaaggat gatgaagtgc tcgtgaaagt 1121161 caagcgagtc ggcatttgcg gttcagacat gcacatttat catggaacga atccgctcgc 1121221 taccctcccg agagtcatcg gacacgaggt aacgggacaa gtggaggcag ttggtgcgaa 1121281 tgtacagagc ctaaaacccg gtgatcatgt ggtgattgag ccgatttctt attgcggatc 1121341 gtgctatgcc tgccgcaaag ggcggccgaa tgtttgcgcc aagctttctg tatttggcgt 1121401 acatgaggac ggaggcatgc gggaatatat tgtgcttccg gaaagacagc ttcacgcggt 1121461 ctcaaaggac ttgccttggg aggaagcagt catggccgag ccttatacga taggcgccca 1121521 ggcagtgtgg agaggccagg tggaaaaagg tgataccgtc ctgatccagg gagcggggcc 1121581 catcgggatc tgtgtgttaa aaatggcaaa actggcgggc gctgctgtca tgatgactga 1121641 cttgaacaac gagcggctgg catttgcgaa agaaaacggc gccgatgctg ttgtaaatgt 1121701 ccaagcagaa catgttgccg agcgggtcct tgaatggact gggaatgaag gagcaaacgt 1121761 ggtcattgat gctgtttgcc tgccggagac ttttgcactt tcaattgagg ctgtgtcacc 1121821 ggcgggacat gtggttgtgc ttggatttga tgaaagagcg gctcagattt ctcagctgcc 1121881 aattacaaaa aaagaagtca cgataaccgg atcccgattg cagaccaatc agtttccaaa 1121941 agtggtagag cttttgaatg gaggccggtt aatgcataac gggctggtga cccatacatt 1122001 ttcagttgat gacgttcatc atgcatttca gtttattaag gagcatccag atcaggtgcg 1122061 gaaagccgtc atcacgtttg attaaatgac tgaatccgga ggtgcgagca tgaatatgac 1122121 attccgatgg tatggacgag gcaacgatac agtcacactt gaatacgtga agcaaattcc 1122181 cggtgtcaaa ggcatcgttt gggctctcca tcaaaagccc gtcggcgacg tgtgggaaaa 1122241 agaagaaatc agagccgaaa ctgaatatat tcaatcctat ggttttcatg ctgaagttgt 1122301 agaaagcgtg aatgttcacg aagcgattaa acttgggaac gaagaacgcg gccggtatat 1122361 tgaaaactac aagcaaacga tccgcaacct tgccggattt ggcgtgaaag tgatctgcta 1122421 taattttatg ccggtttttg attggacacg cacggacatg ttccggccgc tagaagatgg 1122481 atcgaccgct ctgttttttg aaaaggccaa ggtggaaagc cttgatcctc aagagctgat 1122541 tcggacggtg gaggaagcat ccgacatgac actgccgggg tgggagcccg aaaaattggc 1122601 tcggatcaaa gagctttttg ctgcctacag aacggtcgat gaagaaaagc tatgggacaa 1122661 tttatcattc tttttgcagg aaattcttcc tgttgctgag gcctatggtg ttcaaatggc 1122721 cattcatccg gatgacccgc cgtggccgat tttcggactg ccgcgcatta tcacaggaga 1122781 ggcaagctat aagaaactgc gggcgatatc agattcaccg tctaattgta tcaccctttg 1122841 tacaggttca atgggagcca atcccgctaa cgacatggtg gagatcgcta aaacgtatgc 1122901 cggcatcgct ccattttcac atattcgcaa tgtgaaaatt tatgagaatg gcgattttat 1122961 tgaaacatct catttaacaa aggatggttc gatcaacatt caaggcgtga tggaagaact 1123021 gcataagcag gattacgaag gatatgtcag accggatcat gggcgccatc tttggggcga 1123081 gcaatgccgc ccgggatatg gcttatacga tcgggcactt ggcatcatgt atttgaacgg 1123141 gctgtgggac gcttatgaag caatggcaaa aaaagaggtg ggcatatgat cccgctgcat 1123201 gagaacctgg ctggtaaaac ggctgtcatc actggcggca gcggcgtgct ttgctctgcg 1123261 atggcccggg agctagcccg tcatggcatg aaggtggcga ttttgaatcg gacggctgaa 1123321 aaaggccaag cggtcgtgaa ggagataacg gcggctggcg gcacagcgtg cgctgttgct 1123381 gcggatgtgc tggacaggat gtcactggag cgggcaaagg aagacatcct tggccaattt 1123441 ggcgctgttg atctgttaat taacggggct ggcggcaatc atcctgacgc gataaccgat 1123501 gtggagacat atgaagaagc gggagaaggc caatcctttt ttgatatgga tgagaggggc 1123561 tttctaactg tattctccac caacttcacc ggtgcgtttc tggcctcgca agtgtttggt 1123621 aaagaactgc tgaaggcgga ttcacccgcg atcatcaacc tttcttccat gagtgcttat 1123681 tcacctatga cgaaggttcc ggcatacagt gctgcgaaag catccatcaa taattttacg 1123741 atgtggatgg ctgttcattt tgccgaaacc gggctgcggg tcaatgcgat tgccccaggc 1123801 ttctttctga caaaacaaaa tcatgatctg ctgatcaacc aagacggaac gttcaccagc 1123861 cgatctcaca aaattattgc gggaacaccg atgaagcgct tcggaaaacc ggaggatttg 1123921 ctcggtacgc tcctttggct ggcggatgaa tcctattccg gttttgtcac tgggatcacc 1123981 gttcctgtcg atggaggatt tatggcttat tcaggtgtgt aacgaaagcg gtgcaacaga 1124041 aactgaacca acataggggt gaggttgaga tgttttcaaa agataagctt cccgttatcc 1124101 tttttttgtt cctggcaggg gtgattaatt acctggatcg ctcggcgctt tccattgcag 1124161 ctccttttat tcaggatgat ctcacattgt ctgccacaca aatgggcttg attttcagca 1124221 gtttttcgat aggttatgcc atttttaatt ttcttggggg cgtggcatcc gaccgctatg 1124281 gggcaaagct gaccttgttt gtcgcgatgg ttgtttggtc gctgtttagc ggagcagtcg 1124341 ccctcgcttt tggctttgtc agcctgctga ttatacgcat tctcttcgga atgggagaag 1124401 gcccgctttc ggcgaccatc aacaagatgg tgaacaactg gttcccgccg acccagcggg 1124461 cgtccgttat cggtgtaacc aacagcggca cgcccctcgg gggagccatt tccggcccga 1124521 tagtcggcat gatcgcagtg gcgttcagct ggaaggtatc cttcgttctc attatgatta 1124581 ttggattgat atgggcagtg ctctggttca agtttgtcaa agaaaagccg caagagacga 1124641 tcaaggaagc accggcaata aaagcagaaa cgtctcccgg agaaaaaatt ccgctcacct 1124701 tttacctgaa gcaaaaaaca gtcctgttca cggcgttcgc ttttttcgct tacaactaca 1124761 tcctcttctt ctttttgaca tggtttccga gctatcttgt cgacgagcgg ggattaagtg 1124821 ttgaatcgat gagtgtcatc acggtcatac cgtggatttt aggatttatc gggctggctg 1124881 cggggggatt tgtttctgac tatgtgtaca aaaaaacggc ccgaaaaggt gtgctgttct 1124941 cgcgcaaggt tgtgcttgtc acgtgtttgt tttcatcagc tgtcctgatt ggttttgccg 1125001 ggcttgtggc aacgactgcg ggggctgtca ctcttgtcgc tctgtcagtg ttctttcttt 1125061 atttgaccgg tgctatctat tgggctgtca ttcaagatgt ggttgatcaa aacaatgtcg 1125121 gttctgttgg cggcttcatg catttcctcg ccaacacggc aggaattatc ggcccggctt 1125181 taaccggatt tattgttgac caaacaggca cgttttctgg agcatttttg cttgccggtg 1125241 ggctggctgt cttcgcttca cttgctgtga ttcgttttgt ccgtccaatc attggtaagc 1125301 cagcgggaac agaagctgag aatcctgtgt cttattaatc tggaaatata gtgggagagg 1125361 cggtatgttt gatgatacaa tatacagtaa ataatcgcag ccggtatgat aaggaaggga 1125421 attagatggt aaccataaaa gatatcgcaa aactcgcaaa cgtatcccac actactgttt 1125481 ccagagcact caacaacagc ccttacatca aagaacatac gaagaaaaaa atattagagc 1125541 tagcagagca gctcaactat acaccaaatg taaatgcgaa aagtctggcg atgcaaaagt 1125601 cgcatacgat cgggctattc tttacaagca ttacaaacgg aacctcacac agcttctttg 1125661 cagacactat caaaggcgtc aatcaagcca taagtgagga ttacaatctg tatgtgcgcg 1125721 gcattgatga tctgaaaaac tatgactccg ttacaccgat gagatatgac ggcatcattt 1125781 taatgagcca aagtgacatt gataattctt ttatttacca tattcgcgaa aaaaacattc 1125841 cgcttgtcgt gctgaatcgt gatattgatg atcgtaccat cacgaatatt ttgtccaatg 1125901 acaaggaagg ctctcaagaa gctgtagaat acttcattca gtccggacat caagacatcg 1125961 ccatcatcga ggggatcgaa ggctttaaat cctcccagca gcgaaaggaa gggtacttat 1126021 ccgcactgat tcaacatcat attccgatca agcatgaata cagtgtcaaa ggacagtacg 1126081 atatggaaag cggctttcaa gcgatggagc ggctgctggc actgccgaat cctccaaccg 1126141 ctgttttttg ttcgaatgat gacatggcaa tcggagcgat gaatgcgata ttcgcaaagg 1126201 gcctgcgcgt tcctgatgat atttcggtga tcgggtttga tgatattggg ttttcacagt 1126261 acatcacgcc aaggctttca acagtaaagc gcccagtgga gaaaataagc gtgctcggtg 1126321 cgcaaaaact cttgtcgctg atcagcgagc ccgaaacaaa agcagaaaaa atcttggaaa 1126381 acacagaatt tatggtgcgt gattcagtca gacgattgac gacgtgatgt cccgtttttc 1126441 agcgggcatt ctttatacag aaaaatgtta acgtgtgcat aaagtgagag ggaggcaata 1126501 agggtgcaga agctgaataa aaatgtgtac gatcactata ctcagtatcc agaaaaaatt 1126561 ctccaattcg gagaaggaaa ctttcttcgg ggatttatcg attggcagat tgatcaattg 1126621 aatcaacaca ctgattttaa tgggagcgtg gcagttgtcc agccaagagg ctcagaaaaa 1126681 atcaaacgat taaatgagca agatggatta tatacacttt ttttacaagg aatgaaagac 1126741 ggagaagcgg taaacgagca tatgattatc aactcaatca gccggggaat tgacctgttt 1126801 tctgattatg aagcatacaa agaattggca tcaagcgaaa ggcttcggtt tattatctcc 1126861 aacaccactg aggctgggat tgtatgtgat gaaaaagatc gtttagagga taggccgcaa 1126921 aaaacattcc ctgggaaatt aactgcattt ctttactttc gctatcaggc ttttaaagga 1126981 gatcagacaa aagggtgtgt cctgatccca tgtgaactga tcgagaataa cggtgaaaag 1127041 ctgagggaaa cggttcttca ttatgcacat ctgtggaagc tggaggaagg atttacacag 1127101 tggattcatg aggccaatac attttgtaat agtttagtag accggattgt tccgggtttt 1127161 cccgtcgaca gcattgatga gatcacggca gatcttggct atcaggatga tttgatagtt 1127221 gtgggagagc aatattattt gtgggttatc gaggggcctg attggattgg aaaagaactt 1127281 ccctttgcgg ctgcagggct gcatacaaag atcgtcagcg acctcacccc ataccggact 1127341 aaaaaagtaa gaattttaaa tggcgctcat acagcaatga cgccagtggc tttattatac 1127401 ggcttgaaga ctgttaggga tgcagtcgag catccggaag tggggcgatt tataagagag 1127461 ctgattgatg acgaaattct tcctgtttta aaaatggaag gtctttctca gtatgctgac 1127521 gatgtgctga accgttttaa aaacccgtat attaagcatt acctggaaag cattgcattg 1127581 aacgccattt ccaaattcaa aacgagaaac ctgccgactc ttaaggaata tgctgaacaa 1127641 aagggacagc ttcctgaacg cttggtgttt tctttcagcg ctcttctgta tttttatcat 1127701 gataacgaga cattgcagga tgatccggca gttcttcaat ttttcaaaga ggtttggtgt 1127761 caggaggatg gcgacatgct tcggattgca tcaagagtgt taggcgaaca gcggctgtgg 1127821 ggggcagatc tcaatgagat accgaagctg actgatagag tcgctgttta cttgaatcat 1127881 attcatgagc tgggcatgca gagggctctt gaacaatact gcatacaagg gggagaggta 1127941 cgttgaagtc gtttataaag attcataagc aagataatgt ccttcttgct ctgcgggata 1128001 ttcaaaaggg agagaggctg catgcttacg gcgtgtcgat tgaagtaaag gatgatataa 1128061 aaagaggcca taagattgca ttgcagtcta tcaaagaaaa cgacagcatc gtcaagtacg 1128121 ggtttccaat cggtcatgca tcacaagata tctcgatcgg agagcatatt catgtccata 1128181 atacgaaaac aaacctgtct gatatccaat tatacagcta tacaccgaga tttgatgaaa 1128241 atccgtattc taatgagaac cggacgttta aaggttttag aagagaaaac ggagatgcgg 1128301 gtgtacggaa tgaattgtgg attgtcccaa ctgtcggctg tgtcaatgga atagcagaaa 1128361 aaatgctgca gcgttttgtc agagaaacag gggatatcgc tccatttgat aacgtactgg 1128421 tgttaaagca tcaatacgga tgctcgcagc ttggcgacga tcatgaaaat acgaagcaga 1128481 tcctgctgaa tgccattcgc catccaaatg ccggcggcgt cttggtgtta gggcttggct 1128541 gtgaaaacaa tgagctggca agaatgaagg aagcactgca agatgtgaac ttgaagcggg 1128601 tgaagtttct ggaatcccag tcggtgaccg acgaaatgga ggcaggcgtt gctttgctga 1128661 aggaaattca tgaagcggcc aaaggagata agagagaaga cattccgctg tctgaactga 1128721 agatcgggct gaaatgcgga ggttcggacg gtttttccgg cataaccgca aacccgctgc 1128781 ttggacgttt ttcagattat ctcattgcac agggagggag tactgtgctg acggaagtac 1128841 cggaaatgtt cggcgcagaa accatcctga tgcagcgggc tgccaatgaa gaagtgtttc 1128901 ataagatagt cgatttaatc aatgatttca aacaatactt tattaaacat gatcagccgg 1128961 tgtacgaaaa tccttcaccg ggcaacaaag cgggcggcat ttctacactt gaggataaat 1129021 cgctgggctg tacgcaaaaa gcggggattt ctcctgtcac ggatgtcttg aaatacggtg 1129081 aagtactcaa gacaaaaggg ctgactcttt tgagcgcacc gggcaatgat ttgatcgcct 1129141 cctccgcatt ggcggctgcc ggctgccaaa ttgtcctctt tacaacggga agaggcacgc 1129201 cgtttggcac ctttgtcccg acggtgaaag tagcgacaaa caccgagctg tatgaggcga 1129261 agccgcattg gattgatttt aacgcaggcc ttttagcaga ggatgatgtt catgaggaat 1129321 atgtgctgcg tgagtttatc cactatatga ttgaggtggc aagcggccag cttgtgaacc 1129381 atgaaaaaaa tgatttcaaa gaactcgcca tttttaaatc gggtgtgacg ttataataag 1129441 aaaaggctat ccttcaagcg gatagccttc ttcattaaat caattttaaa ccgctgacta 1129501 aaataatgga agccataata aattgcagtg gacgcgggga gaatcgaggc gaaagatggc 1129561 tcccgatcag tacgccggga attgaaccga ggagcagatt agctgccagc atgtaatcca 1129621 cgcttccgaa gcttgcgttc aaaatgcctg ctgccgtaac aagaagaaaa gcatgcgcga 1129681 tatcggttcc gacaatctgt gacgctttca tgttaaataa gtaaatcatg gcgattgcaa 1129741 ataatgagcc ggacccgatt gatgttaatc cgacgataaa cccaaacaca acaccaataa 1129801 gaattgtcag cgccctctta ttttcaagcg gcatcagctg ccagcggttg gggcgaagtt 1129861 ttctatccaa aaacaaacga acgatgattg aaatggcaac cagcgttaac acatatccta 1129921 gagcgtgctt aataatttct tcctgatgct ggtgaaaggc ggggaacaaa tgcaatatgc 1129981 caatggctag cgaagcactc ggaataccgc cgatggctaa gtattttacc aatttaaagt 1130041 taatcgtttt ctgccgccaa tgggaggcaa cgccaaacag ctttgtgatc gagttatata 1130101 caagatccgt accgaccgcg atggaaggat taattccaag cacaattaaa aggggagtta 1130161 ataaggccgc tccacccact cccgtcaatc cgactaaggc tccgacaaac aaacccatca 1130221 atatgatgct tacactcatg ataaaggcct cctgaaaacc cgactagaat tcacccgaat 1130281 cttattcgcg ttggtcaagt attaattgta agtgctccat cggctgctga aaaacccgag 1130341 ctctatccgc tccctgatgg tatcattcaa ttgacaacac cttatacatc aggagaacac 1130401 gtctttcagg tgcaacgagc acttgcggct ctgtattttt accctgataa aggcgctgtt 1130461 aacaacggaa ttgacggcgt ttacggaccg aaaacagctg acgcagttgc ccgttttcag 1130521 tctgttaacg gtctaactgc tgacggtatc tacgggcctg cgacgaaaga gaagatcgca 1130581 gcgcaattaa gctgatcaaa gaccataaaa atcccggagc cgctccggga tttatttttt 1130641 cttcttcaac ttttttataa ttccagcact gcgctccctc acccgaagcg agtacccgga 1130701 aagcccaaac cttccgtaat caacaaactt cacacgcctc accaattttt tcactgtatc 1130761 acctgacatt atcctctgtt tgtatttatt atatgtcacc ctttaagaaa aggaataagg 1130821 acaagagctg ttttcccttg tccttttagt gtgatcatgc tttttttcgt ttatactcgt 1130881 caatcagccg ttcgttttct ttgaagattc ttgctgtatg cggactgact tgatagcttg 1130941 cgacactggt ggttgaacgt tttttcagga ttttaaacgg cttcgccgct ctgggctcgc 1131001 atctgttttg aaacgcacgt tccattatcc ttcaccttcc tcctcaattg gcagcaccaa 1131061 atcatatatg ctcgttaatg acgtaaatag caaataatca aattccgtga caatgctgtc 1131121 agacgtcagc ttgatgacat agttctgtgt ctcgatggta aaagggatga gaaccacttt 1131181 tccgtattgg tcgtaataaa catcctttcg atcgagccgt gtttgtacat ctgccggatc 1131241 atccatatgc tcggttaacc ggtctttatc agcctgtgtc gaatagtggc aaagagaagc 1131301 cgttaagttc attttatcag cataggtttt cagcagctta tcaatacctt cagcataagc 1131361 atctatactt ccataataaa catggatcgg ttcgtttttc aataggtatt ggtatgtttt 1131421 cagccgattg agatacatgt ggagcatttc gttgttttct tcaagaattt ctcttgtgtc 1131481 tgtttcaagc tcgctgccgg ccagtttttt gacatatgca cttaagaaga taaaagcatc 1131541 aatcaaagca aaactgactg cgacaatgag ataccgttcc cagtgggtaa atagggaagt 1131601 gggctcatat gtccagtata ccatagcgcc cagaacaaac agcaaatacc aagttttccg 1131661 aatggcggac attttttctt tgaccttcgc ttcgaaacgc cacgtggcat acacgtataa 1131721 ccccagtccg gccacgatgc accagaccat gatctgaaag aataaaacca tattcgaatc 1131781 cctcacatct gaaataggtt ctgcttattg tattcgagag atccggatgg ttttcctgtt 1131841 ccatcaaaaa aaccgctcct ttgacagaag cggtgtgaca ttaaaatatc atatttaaaa 1131901 taaagtaggc gatggcacca agtgtcgctg aaatcggaag cgtgatgacc catgtaatga 1131961 gcattcgctt ggccgtaccc cagtttacgc cttttacgcg gtgggacgca ccgacgccaa 1132021 gaattgatga agaaatgacg tgggttgtac tgaccggcaa atgaataaac gtggcgccga 1132081 aaataatggc tgctccggtt aagtcagcgg aaacaccgtt taccggacgg attttcatga 1132141 tctttccgcc aacggttttg atgattttcc agccgccgat tgatgttccg agacccatgg 1132201 ctgtcgcgca ggcgaattgc acccaggtag gaatatcatt agcagaagta tgtaaattcg 1132261 ctgtgatgag agccattgtg ataattccca ttgctttttg cgcatcgttt gttccgtgtg 1132321 tatacgattg cagggcagct gttacaatct gcactctgcg gaattgctta ttcgttttcg 1132381 ccaagttgct gtctttgaaa atcagcttaa cgatgctata aagaataaaa ccaaggacaa 1132441 aggcaataat tggtgataga atcagtgctt caatgatttt aatgaagccc ttatagttta 1132501 acgctgcaaa tccggctgcc gcaatggctg caccggcaat agcgccgatg atggcatggg 1132561 atgagctgct tgggataccg tagtaccatg tgataaggtt ccaggcaatt gcagcgagta 1132621 gcgcagccaa aatgacaaca gagccatttt ccagcgtata aggatctacg atgtctttcg 1132681 taatggtttt ggcaacacct gtaaacgtca ttgctccgac aaagttcatc acagcagcca 1132741 atataatggc atggcgcggt tttaacgctt ttgttgatac cgaagtcgca attgcgtttg 1132801 ccgtatcatg aaacccgttg atgaaatcaa acgccagagc acaaatgact attagtatcg 1132861 ttaatattaa tagaatatcc atttttaccc ctcgttacgc gtttttcata atgatggttt 1132921 caagattatt ggcaacactt tgacaagagt cggcgatttc ttcaagcgtt tcgtatattt 1132981 cacgatattg aatgactttg attggatctg tttcatttcc gaaaagattc tttaatgatt 1133041 ttctgtgcaa gttgtcacaa ctgtgctcat actctttaat tttgattgcg tgaggctgaa 1133101 tatcctttaa gcgattttct gccagcagct cgatcgtaat caaaatctct ttcgcacatt 1133161 ctctgatata tccgctgaat ttatcaatat gctcgtctga tgaagtaatt gagaaaatct 1133221 ccatcatggc agagaaatgt tcgattccgt caagcacatc atccaagctg tttgtcagct 1133281 gaaggatatc ttcgcgctca ataggagtga tgaacgcttt gttaagctct ttaatcatga 1133341 catgaacatg attgtcacct tttgtttcat attcctttaa cgtatctgca aattctttaa 1133401 gagtcgtttg gttagtgacc ttaaaattca caaaatattc tgcagtttcg tctatgttct 1133461 ttgcaatttc tgttaaaagg agtgagaact tatctttttt tcttcttatc attaaaaacc 1133521 ctccatagtt tgaatgaaca atgcacacat caaattatta tatagccttt tgtcgaaaaa 1133581 aaacaggtaa agtcgaaaaa aacgtatctt gacttttttg ataaatcgtg tctccttatt 1133641 ttgacctact tcgctttaaa aaaacgaccc aagtttgcaa aaactttctg cttaacgtaa 1133701 aaagtatatc aaaagttgtg tttttcctgt caacttttat cttctgtttc accaaaaaac 1133761 ggttccctaa acaagggaac cgttttatca gcttgctttt cgttttttca tcccgtaata 1133821 aacaggcagt ccggcaaggc cgatgaggat ggataatccg cagctcattg tatctgtaat 1133881 gagtgtgctg cctaacacaa agaaggagcc cgcgattgcc agaattggca taaatggata 1133941 aagcggaaca ctgtaggcgc gcttttctcc ctttgctcgc ttgcggagaa taaacactgc 1134001 aaaaaaggcc atcacataaa aaatgtagat catgaaaatg gagatttctg agagcttatc 1134061 agggttgctg atcagcatca taatcaaagc caaagcaatt tgaaaagaaa tcgcaatcca 1134121 tggtgtgcgg aacgacgggt gtacatgtga cagtttttca gcaaatggaa gctgtttgcg 1134181 ttccgccatt gcaaatgaaa cacgcgggaa agaaagcacc tttccattta agcacccaaa 1134241 gatgctgacg ataatcccta cactgatcag ctttccgcca attgaaccga acagcatggt 1134301 tgcagcggtg cttgtcgcat tttcaccaag cgtgacaatt tcgttcgctg acaggatgtg 1134361 aagcaatgca aaattaatga aaatatagat cgccgttaca attaataatc cgcccgtcat 1134421 agcgcgtggc agcagctttt cgggattttt catttctccg ccgagagcgg caaggagaat 1134481 ccatccgtca taagcaaaca acgtagctaa aatagccgcc ccgaagttca tatcagaaat 1134541 gctttcgttt actgctgtga agatgtgctg atcgcctttc caaaggccaa agacgatgat 1134601 gcaggcaatc ggaatcagtt ttccgatcgt tgtcagcgtt tggacaaaac cgccgtattt 1134661 tgtaccgata atattaatga cgcataaaaa gagaactgct ataattccaa tgacttttga 1134721 tagtccagat ccccagccga aaagattcgc cattaaagat ccaaaatata aacccagcgc 1134781 gccaataatc gccgggccgt aaatgataat ctgcacccag ccgcacaaaa atccccaaaa 1134841 ctcgccgtac acttcttcaa ggtacgtata aagcccgccg gtttttggaa tctgcgttcc 1134901 gatttccgcg attgtcaaac cgcccgccag tgttaaaata ccgcctaaca gccaggcgaa 1134961 aagcgccatt tttgaatcac ctgaataagc aagcacagcg ccgggcttca taaaaacacc 1135021 agaaccgata atggttccga tgacaagagt aagggcaaac aagaggccta tctctttttt 1135081 caaaccgttg tcttcagtat gcatgtcctt aacctcctat gatgttgaag cttcatgttg 1135141 aagaatctat tttttcatat tgtaaaccct attttagaaa agtgaaataa aataaatttt 1135201 ctgattttcg aaatttgctt tgtgtacagc agataaaact gtagaaatac ctgttttaat 1135261 ggtctataaa cgaataaaat tcataatttt tatttacaaa gttcgtgttt tatgtattag 1135321 gattttagcc ggtacagagg ggagatgaga attcagaaaa tgaacgaacc ttcggtgaag 1135381 ctgatatgtt gactttctca tgcgaataaa atactttgtt attagaacaa taaatataca 1135441 attatgatat gatatctcga aatcgagata aaataacctg gagggacagc atatgaaagt 1135501 taacggcatt caccacgtat cggcattaac ggccgacgca caaaaaaact tggatttcta 1135561 taagaaagta ttaggattaa agctcgtcaa aaaatccgtc aatcaggatg aaccgacaat 1135621 gtaccatctg ttctacggag atgaagtggc aaacccggga actgagctga cgtttttcga 1135681 gattccccgc attgcaccgt ttcatgcggg aacaaacagt atttcttcta ttggattgcg 1135741 cgttccaggc acagaagccc tgcattactg gaaagaacgt tttgaagagc agcaagtaac 1135801 gcacagcggc atctccaaaa gagccggacg tgacatattg gcatttcaag atcatgaggg 1135861 gcagcgactt gtgctgactg ctgatgagga aggaaaagga tatggcctgc ctgttaaaca 1135921 gagcggcatt ccggaagaat tttcgtttcg cgggttaggg ccggttgaac tgactgtgcc 1135981 atatgctgaa ccaactttac acgtattgac gaatattctt ggatttacag aaatcagccg 1136041 tgaaccagtc gaagggcaag gaaccgccgt tattctggaa tcaggagaag gcggtgctgc 1136101 aacggaaatc catttaatag aaagaaacga tcttccgcga gagcgtcaag gcaaagggag 1136161 tgttcaccac gtcgcatttc gggtaagaga tgaagaagaa cttgccgggt ggcaccggat 1136221 catcagccgc gaaggcttta gcaattcagg catagttgag cgctactatt tcaaggcgct 1136281 gtatttcaga gaaccgaacg gcattttgtt cgagttatca acagacggac cgggctttat 1136341 ggtagatgaa aatcttgatg agcttggcca aacgattgct cttccgccat atctagagca 1136401 tcgaagagca gaaattgaag caaaattgaa accgatccaa taaattgtga ttcttttgcc 1136461 ttccggcgcc gccggagggc tttttttatt accataatta attttgacct aaacagcatg 1136521 ccttattagg gaggaaatat cagatgctga ttgggagaaa tggcttaaaa ccctttgcaa 1136581 atatgggtga ttggtatgga atggcctcgg caaaaatatt gtctttgttt attaatagtt 1136641 tattcatatt tgcttgttac actatttcaa agttagacaa aaaggagtga aaaataagtg 1136701 gaaaagaaaa aacgcgagct ggatatcgtc ctcctcctca ttttgctcgc atctgcattc 1136761 ttaaatatct ataacatttg gaaggacgac acggtgaatc cttattacac cgcggcagtt 1136821 acaagtatga tgcaaagctt tcataatttc ttttatgctt cgttcgatgc tgccggcttt 1136881 ataacagtag ataaaccgcc tgttacatac caaatccaaa cgatcagcgc actgatattc 1136941 ggtatgcacg gctggagcgt catcctgcct caggcacttg ctggtgtagg ttctgtcctt 1137001 cttatgtact tgctgataaa gccgacattt ggaaaaacgg cggcgcgtat tgcctcattt 1137061 gttatggcat gtacgccgat agctgtagct gtagcacgta caaacaatgt tgatgcatta 1137121 ctggtatttt tcttattgct tgctacatgg cttctcttta aagcgatcag aaaaggaaag 1137181 ctgatctggc tgttagcagc atttttcgtt gttggagtag gttttaatac aaaaatgctg 1137241 caggcttaca tgattttacc ggctttctta ttgttctatc tgattgcggc aaacgccaca 1137301 atcaagaaaa aaatcgtttc attggtaagt gcgttagccg tattagcagc cgtttcgtta 1137361 tcgtggccgc tcattgttga caatatccct gcaagcaagc ggccttatat cggaagcagc 1137421 caaaccaact ctgttttgga attggctttc ggctataacg gaatccagcg gctgacaggc 1137481 caaaattcag gcggcggcca gggtgcgcca aacaaagacg cttcaaaaga aatgtcttct 1137541 tctgataaca ctcaagcacc gcctaatcag tcatcaagca acagctcatc aagcgatggt 1137601 aaatcctcaa atggcaatat ggcggcgcct ccatccaatg gccaaatgcc aagcggcggt 1137661 caaggaggcc ctccaagcgg cggagatggc ggccaaggcg gacccggcgg agacggaggg 1137721 aaaggcggta caggaaccgg ttcgaaaatg caatcaggtt cagggatgtt tggaacggga 1137781 acacctggtc cactgcggct tttccaacaa gagttatctg atcaaatcag ctggcttctg 1137841 ccatttgcga tatttggaat cgcaggctta ctgatcgctg gcgcaagaga aagaagaaga 1137901 ttatctgtag agcagaagga aacggtgttc tgggttgcgt ggcttgtacc gattgccgga 1137961 ttcttcagtg tcgcagaatt tttccatcat tattatctca tcatgctggc accgccgatt 1138021 gcggctcttg tcggtgcggg gtgggtcgct cttgttcatc tgtaccgcaa tcagacaggc 1138081 tggaaagcat ggcttttgcc gggagcaatt attgcgacaa ctggatttga attgtttatt 1138141 ctcagaaact acaacgatca aatcggtgtt ggatggagta tcggggtagg tgttatcggc 1138201 gtgttgtcag cgattgcttt gctgctgttt aaacagcgcc aaaaaccgtt cagttattat 1138261 gtttcacttg cagctctcct cgcattgctg gtgatgccga tgtattgggc aagtacaccg 1138321 cttctgtacg gaggcaacag ctcactgcct gaaacaggcc ctcaactcgc atcaatgagc 1138381 ggaaaaggca tgggaatgtc tgatgcgact gtaaatgaaa aactgatcaa atatctagag 1138441 gagaataact ccggagctga atacctattc gccacaaccg attcgaacac agcggcacca 1138501 tatatcatta aaacgaaaaa agctgtcatg gctattggtg gatacagcgg ttctgacccg 1138561 gcaatcacac tgactcaatt caaaaaactt gtaaaagaag gaaaagtgaa atacttcttg 1138621 gcttctggaa tgggaagagg cggaaacaat gacattgttg aatgggttga gaaaaatgga 1138681 aaagaagtag catcagaaaa atggcaatca agttctgatc aaaaaacaga aaatactgat 1138741 tcagctgata catcaagcag caaggcttca ggtgaaaacg gcaaaatggg cggacctggc 1138801 ggaatgaatc agtcagcaac attatacgaa ctacatgctg atgaatagga ggcaaaaaca 1138861 tgagcagaca tattcaatat tcaattgttg tacctgtgta taatgaagag cttgtcattc 1138921 atgaaaccta tcagcgctta aaagaggtca tggatcaaac gaaggaaaac tacgagctgc 1138981 tttttgtcaa cgatggcagc aaagaccgca gtattgagat tttaagagag cacagcctga 1139041 tcgatccgag agtgaaaatt attgattttt caaggaattt tggacatcag atcgccatta 1139101 cggcaggtat ggattatgca caggggaatg caatcgtcgt cattgacgcc gatttgcagg 1139161 accctcctga actgatttta gaaatgattg aaaagtggaa ggaaggctat gaagtcgtgt 1139221 acgccgtacg gactaaacga aaaggggaaa cctttttcaa aaaacaaacc gcggctatgt 1139281 tttaccggct tctcagcggt atgacagata ttgatatccc gattgatacg ggggattttc 1139341 gcctcatgga cagaaaagtc tgtgatgaaa tgaagagatt aaaagaaaaa aatccatttg 1139401 taagagggct agtcagctgg gtgggtttca aacagacagc ggtcgagtat gtacgtgatg 1139461 aaaggctcgc cggagaaaca aagtacccgc tcaagaaaat gctgaagctg tcaatggacg 1139521 gcatcacgac attttcacat aaaccgctga agctggcaag ctatgcgggg attttaatgt 1139581 caggtactgg atttctgtat atgtttatcg tgctgtatct gaagctattc acagacagca 1139641 cgattaccgg ctggtcatca cttattgtga tccagctcct gttcagcggc attgtccttc 1139701 tgattttggg cgtgattggc gaatatatcg gcagaatcta cgatgaagcc aaagacaggc 1139761 cgctttacat cgtccaaaaa tcgtatggaa ttgaaaataa aagactctat agagaccagc 1139821 atatgtcata acctcaaacc ccctgtccgt aatggacagg gggtttttat gctctgagca 1139881 cgatctaaag caaaagatgc tgatagatat atggaaattg ggtaaagaag agattgtgag 1139941 cttgtactgc ggttcagtca tgctgaaata aaaacagcaa aacttaaaga tttcgtcctc 1140001 ggctttgctg catgtcagct gttatattgg ggggctttta agaaacgcat gattagagcc 1140061 gtaccagtta tgtttaatag aatactcgta cccaatacaa ttccccacgt caacgtcgat 1140121 tcagagagaa gaaagctcag caaaagaaaa gccaatcctg cgcagatcat acccagtccc 1140181 acggttttca tgttcatgcc tcctagcaaa cgatgtttct agcatctgat gtgaatgatg 1140241 tcaatctgta tgatatacgg atatctcgtc agaaagtttc atagaacaat taggtctttt 1140301 atctaataaa aagcctcaga ccgcttttac ggcctgaggc attatgtctt acgaagtttt 1140361 ctcttctttt tgatccagtt taattttttt cgtcatttct ttgccgtttc ggagaatttt 1140421 cacttcaacg gtatcaccga tctttgcgtc tttatataag atattgcgca attcactgcc 1140481 tgtatcaatt tctttacctt ttaggccgat gataatatcc tccgctttta atccggcctt 1140541 ttcagcagga gagcctgaag cgacctcacg gatgtaaacg cctttattca gctggctgcc 1140601 gaacaggccg agtgtgcctt cttggtaatt ttgcggcact tgctctagat caagcatgct 1140661 gacaccgata tatggacgtt caatttgtcc tttagacagc aattcttcag caatcggttt 1140721 tacgtcattg cttggaatgg cgaatccgat accctcaaca tcatcctcac tgattttcat 1140781 actgttaatg ccgacaattt tgccgtctgt atttaacaaa ggaccgccgc tgttacctgg 1140841 attaattgct gcgtctgtct gaatgacgtt aatgctcgtt tcgccggctg atgtagacat 1140901 tgaaaccgtt ctgtccacgc cgcttacaat tccttgtgtt actgtgcggg acaggtcttt 1140961 tccaagcgga tccccaatcg caataacggt ctcgcctgtt ctaagatcag atgaatcacc 1141021 gaagtttgcc acttttgtga cgtggtcatc actgatttgg aggacggcta aatcagttaa 1141081 cgagtcactg cctaccagct ttgcagtaac ctcagtgccg tcatataaag ataccttcag 1141141 tgatgatgcc ccttctacga cgtggttatt tgtaatgata taagccttgc cattctcttt 1141201 tttgaaaatg acacctgacc ctgaaccgct ttctgtatct tcgctggaat cagaagaact 1141261 agagccgaac aaagagctgt ttgattgtgc ctgaagattt gtaataccga caatcgctgg 1141321 tgaaaggtct tctaccatat ctgagatttt agaagagtcc tcgctcttga atgcagatga 1141381 gctgcttgag ctttttttag attcagagga ggtgcttgtt gctgtaacag attgcgtttg 1141441 ctgctggctg gatgattgtt ttgcagtgtc ctgagaatca tggtcaccaa gcggtgtaaa 1141501 cgtgtaaatg ccaagagcaa gactgccgcc gatcactccg ccaagcaacg gtctgaacca 1141561 tccgaatcct cgttttttct tctcctgatc atgaatgaca ttgcgggccg agtaggaggc 1141621 gctctgatcg ttctctttcg ttaaaaagac ctcattctca ttacctttcg ttctgttttc 1141681 atcacgatag ttatccatca tgttcactcc gtttctctat tttcacatgt ctatttatat 1141741 tgataggttt atgacttgag tttatcataa acaaaaactg tgggataaaa atgaaaagat 1141801 tatgggaaat tgtgaaaaag tgcggaaaac ggtacacttc atattgtata tgaaaggact 1141861 gagtcgatgg aacagattgg attgattgga tatggcagca tggcggatat gatcgctaga 1141921 cagctgttga aacatgaaca aataaaagag aatgagctat ttattgagac gagaacgaag 1141981 ggggagcggc tgcgggcact catgtcagat tatccaaacg tatcggctga tccgttggag 1142041 aattgggcaa atacgtgcca attgattttg atatgcgtcc cgccactcca tgtcatcgaa 1142101 acaatgcgcc gtctgtaccc gtatgtgaac agaaatactc acatcgtatc catagctgcc 1142161 ggtgtgccgc tgcgtctttt ggaggcagaa acagaagccg gtatctcacg tgttattcct 1142221 gccattacgt ccgaagcaga agccggcatc tcacttgtcg ttcacagtga agcactggct 1142281 gcagagaaaa aagaacgtct gaatgaattg ttatcggttt tcagccgtgt acgggaaatc 1142341 aaagaatcga atttagatgt ggccagcaat ttaacgagct cggcaccggg attcatagct 1142401 gcaatctttg aagaactggc actgtctgcc gtcagaaaca gcagcctgtc caaagaagaa 1142461 gcctttgatt ttctgattca ttcgctatac ggaactggca agatgctgat cgaaaaaaat 1142521 atgtctttcg aggagacgct ggaacgtgtt gcaaccaaag gcggaataac gggagaggga 1142581 gctgaggtga tacacgcctc tgtgccggac gtttttgatg aggtatttga aagaaccctg 1142641 agaaaatatg aactgcttac agaacaggtt ggtaaacaaa catgaatcct tgaaagagga 1142701 ttcttttttt atcactgaat gattgagatt tttcccagtt atattgcatt tttcctcttt 1142761 ttttaatata atttgttaga atattcataa tttagtaaaa aaggaggagc gttatgaaat 1142821 tgtacatgtc agtagatatg gaaggtattt cgggtcttcc ggacgatacc tttgtggatt 1142881 ccggcaagcg gaattatgaa cgcggacggc ttatcatgac tgaagaagca aactactgta 1142941 ttgctgaagc gtttaacagc gggtgtaccg aggtgctggt caatgacagt cattcgaaga 1143001 tgaataatct gatggttgaa aagcttcacc ctgaagcaga cttgatttct ggtgacgtca 1143061 aaccattttc aatggtggag ggactggatg atacgtttag aggcgctttg tttctcggtt 1143121 atcatgcgag agcctcgact cctggtgtca tgtcacacag catgattttc ggcgtccgtc 1143181 atttttacat aaacgatcgg cctgtcggtg agcttggatt aaatgcatac gttgccggtt 1143241 attatgatgt cccggtatta atggtagccg gggatgaccg ggcggcgaag gaagcagaag 1143301 agcttatccc gaacgtgacg acagccgcag tcaaacaaac catttcaaga tccgcagtga 1143361 agtgcttgtc gcctgcgaaa gccggacggc tgttgacaga aaaaaccgca tttgccctgc 1143421 aaaacaagga caaagtcaag ccgctcacac cgcctgacag gccagttctg agcattgaat 1143481 tcgccaatta tggccaagca gaatgggcga atctgatgcc gggaacggaa atcaagacgg 1143541 gaactacaac cgttcaattt caggcgaagg acatgcttga agcctatcag gcgatgcttg 1143601 tcatgactga gcttgcgatg cggacatcat tctgctaaag gggtgtttta ggctttggcg 1143661 cgatacatga taaagcgttt ttgggcaatg gcagctacga ttttggtgat taccaccctg 1143721 acttttgttc tcatgaaggt cattcccgga tctcctttta acgaggagag aggcacaaat 1143781 gaagccgttc aaaaaaatct cgaagcctac tatcacttag acgatcctct cattttccaa 1143841 tacattttct acttaaaatc catcattaca ttcgatttcg gaccttcaat taaaaaaccg 1143901 tcggacagcg taaatgatat gctggaacgc ggatttcccg tttcctttga gcttgggatg 1143961 acagcgattg tcattgctgt gatttctggg ctggtgctgg gcgtaatcgc tgcactccgc 1144021 cgcaatggct ttttggacta cgccgcgatg agtcttgcag tactcggcat ctccatcccg 1144081 aattttattc tggcaacatt gctcattcag caatttgctg tcaatctcaa actatttccc 1144141 gctgcgacat ggacgagccc gattcatatg gtgcttccga ccgcagcgct tgctgtaggg 1144201 ccaatggcga tcattgccag gctgacacgg tcgagcatgg tcgaagttct gacacaggat 1144261 tatatccgca cagcaaaagc aaaagggctt tctccgttca aaattatcgt aaaacacgca 1144321 ctcagaaatg cactcatgcc cgtcattacc gtcctgggca cactcgtcgc cagcatctta 1144381 acaggaagct ttgtcattga aaaaatcttt gccattccgg gaatgggaaa atattttgtt 1144441 gaaagcatta atcagcggga ctaccccgtg attatgggaa cgaccgtttt ttacagcgtc 1144501 attctgatta tcatgctgtt tttggtcgat ttggcctacg gtctcttaga cccgcgcatt 1144561 aaactgcata agaaagggtg aagcgtgtga atctccctgt acaaacggat gaacgccagc 1144621 cagaacagca caatcaggtg cctgatgagt ggtttgtctt gaatcaggaa aaaaatcggg 1144681 aagccgattc ggtcaagcgg ccgagtttgt catacacgca ggatgcctgg aggaggctga 1144741 aaaaaaataa attagcgatg gccggactct ttattctttt atttcttttt gtcatggcag 1144801 ttatcgggcc ctttttatcg ccccatagtg tcgtacgcca atcgctgaca gaacaaaatc 1144861 ttccgccctc agccgatcat tggttcggca ccgatgaact cggccgggat gtgtttaccc 1144921 gaacatggta tggcgcgaga atctcgttgt ttgtcggcgt gatggcagca ctgattgatt 1144981 ttttgatcgg tgtcatttac ggaggcgttg ccggctataa aggcggcagg attgacagca 1145041 ttatgatgcg gattatcgaa gtgctgtacg gactgccgta tctgcttgtt gtcattttgc 1145101 tgatggtgct catgggaccg ggactgggca cgattattgt ggcgctgact gtgaccgggt 1145161 gggtcggcat ggcgagaatt gtaagaggcc aggtgcttca gattaaaaat tatgaatatg 1145221 tactcgcctc gaaaaccttt ggcgcgaaaa cctttcgcat catccggaag aatttgctgc 1145281 cgaatactat gggagcgatc atcgtacaaa tgacattaac cgtacctgcc gccatattcg 1145341 cagaatcatt tttaagcttt ctcggcctgg gcatacaggc tccgtttgca agttggggcg 1145401 tgatggcgaa tgacggcctg cctacgattt tatctgggca ttggtggcgc ctgttttttc 1145461 cggccttttt catatctctg acgatgtacg cgtttaatgt gctgggggac ggattgcagg 1145521 atgcgcttga ccctaagctg aggaggtagc tgtatggaaa aagttctgtc agtccaaaat 1145581 ctgcacgtgt cttttacgac ttacggcggg acggttcagg cggtcagagg ggtgagcttt 1145641 gatttgtata aaggagaaac ctttgcgatc gtcggcgaat ccggctgcgg caaaagcgtt 1145701 acctcccaaa gcatcatggg cctgcttccg ccttattcgg cgaaggtgac agacggcagg 1145761 attctattta aaaacaaaga cctttgccgt ctctctgaca aagaaatgag aggtataagg 1145821 ggagccgaca tttctatgat ttttcaagac ccgatgacgg cgttaaaccc tacgctgact 1145881 gtcggcgacc agctggggga agcgctattg cgccacaaaa aaatgagcaa aaaagcggca 1145941 cggaaagagg tgctttccat gctgtcattg gttggtattc cagatcccgg agagcgccta 1146001 aagcaatatc cccaccaatt cagcggcggt atgagacagc ggattgtcat tgcgatggcg 1146061 ctgatttgcg agcctgatat cttaattgcg gatgaaccga ccaccgccct ggatgtaacc 1146121 attcaggcac agattttaga gctgtttaaa gagattcaga gaaaaacgga tgtgtctgtc 1146181 attctgatta cgcacgattt aggggttgtt gcccaggtag ctgacagagt cgcagtcatg 1146241 tatgccggga aaatggcgga aatcggcaca agaaaagata ttttttatca gccgcagcac 1146301 ccatatacaa aaggcctgct gggctctgtc ccgcggctgg atttaaatgg cgctgagctg 1146361 accccgattg acggaacgcc gccggattta ttttcgcctc cgccgggctg cccgtttgcc 1146421 gcccgctgtc cgaacaggat ggttgtgtgt gacagggtgt acccgggcca gacgatcaga 1146481 tctgactcgc acaccgtcaa ctgctggctg caggatcaac gagcagagca tgcggtgctg 1146541 tcaggagatg cgaaggattg aacatgaaaa gggggaagag gatgaaacga gtgaaaaagc 1146601 tatggggcat gggtcttgca ttaggacttt cgtttgcgct gatggggtgc acagcaaatg 1146661 aacaggccgg aaaagaaggc agtcatgata aggcaaaaac cagcggagaa aaggtgctgt 1146721 atgtaaataa tgaaaatgaa ccgacttcat tcgatccgcc gatcggcttt aataatgtgt 1146781 catggcagcc gttaaataac atcatggagg ggctgacgcg tcttggcaaa gatcatgagc 1146841 ccgagccggc aatggcggag aaatggtctg tttcgaaaga taataaaact tacacattta 1146901 cgattcggga aaatgcgaaa tggacaaacg gagatcctgt aacagccgga gacttcgaat 1146961 acgcgtggaa gcggatgctt gatccgaaaa aaggcgcttc atcggcattc ctaggttatt 1147021 ttattgaagg cggcgaagca tataacagcg ggaaagggaa aaaagacgat gtgaaggtga 1147081 cggcaaagga tgatcgaacc cttgaagtta cactggaagc accgcaaaaa tatttcctga 1147141 gcgttgtgtc caatcccgcg tatttcccgg taaatgaaaa ggtcgataaa gacaatccaa 1147201 agtggtttgc tgagtcggat acatttgtcg gaaacggccc gtttaagctg acggaatgga 1147261 agcatgatga cagcatcaca atggagaaaa gcgacacgta ttgggataag gatacagtga 1147321 agcttgataa ggtgaaatgg gcgatggtca gtgacagaaa tacagattac cagatgtttc 1147381 aatcagggga acttgatacc gcttatgtcc ctgctgagct gagtgatcag ctgcttgatc 1147441 aggataacgt caatattgtt gaccaggcgg gtctctattt ctatcgattt aatgtcaaca 1147501 tggagccgtt ccaaaatgaa aacatcagaa aagcctttgc gatggctgtg gatcaagagg 1147561 aaattgtaaa gtacgtcacg aaaaataatg aaaaaccggc gcacgccttt gtatcgcctg 1147621 ggtttacgca gcctgacggc aaagatttcc gtgaagcagg cggagacctg atcaagccta 1147681 acgaaagcaa agcgaagcag ctgctcgaaa agggcatgaa ggaagaaaac tataataagc 1147741 ttcctgcgat cacgcttact tacagcacaa agccggagca taaaaagatt gccgaagcta 1147801 ttcagcaaaa attgaaaaat agccttggag tcgatgtgaa gctggccaat atggaatgga 1147861 acgtattttt agaggatcaa aaagcgctga aattccaatt ctctcaaagc tcatttttgc 1147921 ctgattatgc agaccctatc agttttctgg aagcctttca aacgggaaat tcgatgaacc 1147981 gcacaggctg ggccaataaa gaatacgatc agctgatcaa acaggcgaaa aacgaagccg 1148041 atgaaaaaac acggttctct cttatgcatc aagctgaaga gctgctcatc aatgaagcgc 1148101 cgatcattcc ggtttatttt tataatcagg ttcacctgca aaatgaacaa gtaaaaggaa 1148161 ttgtccgtca ccctgtcggc tatatcgatt taaaatgggc agataaaaac tgatggaggc 1148221 gattgaggaa atactgcttc tttatgcgaa ggagcggtat tttttctctt tcttgcacgt 1148281 atacgtaggg tgcagagcaa atgaaaggag tgttttcgtt gaattacaag ccgaaagcgt 1148341 tgaacaaggg tgatacagtc ggagtgatcg cgcccgcaag tccgccggat ccaaaaaagc 1148401 ttgacaccgc gcttttattt ttagaagagc tcggtcttca ggtgaagttg ggcaaggcgc 1148461 tgaaaaacca gcacggctat ttagcgggac aggatgatga gcggctggcg gatctccatg 1148521 agatgttcag agacgatgag gtaaaagcag tgttgtgcgc atgcgggggt tttgggacag 1148581 gacgtatcgc cgcgggcatt gatttcagct tgatccgcaa acaccctaaa atcttttggg 1148641 gatacagcga tattacgttt ttacatactg ccattcatca aaacacaggt cttgtcactt 1148701 tccatggccc gatgctcagc acggatattg gccttgacga cgttcacccg ctgacaaaag 1148761 cgtcatataa gcagctcttc caggagacgg aattcaccta tacagaagag ctttctccgc 1148821 tgaccgagct tgttcctgga aaagcggaag gcgagcttgt cgggggaaat ctgtctttgc 1148881 tgacgtctac actgggcacg ccatttgaaa ttgatacgag aggaaagctt ctgtttattg 1148941 aagatattga cgaggagcct tatcaaatcg accggatgct gaatcagctg aaaatggggg 1149001 ggaagctgac ggacgcggcg ggaattctag tttgtgattt tcacaattgt gtcccggtga 1149061 agcgagagaa gtctctctcg cttgagcagg tgctggaaga ctatattatt tctgcgggca 1149121 ggcctgctct gagaggattt aaaatcggcc actgctcgcc aagtattgcc gttccgatcg 1149181 gtgcgaaagc tgctatgaat acagcagaaa aaacagccgt aatagaggcg ggcgtttcag 1149241 aaggggcgct gaagacatga aaatcattcg aatcgaaaca agccgaatcg ctgtcccgct 1149301 gacaaagccg tttaaaaccg cacttcgcac tgtgtatacg gctgaatcag tcatagtaag 1149361 gattacttat gacagcggtg cagtcggatg gggagaagca cccccgacgt tagtgattac 1149421 aggagacagc atggatagca ttgaaagtgc catccaccat gtgttgaagc cggcattgct 1149481 tggaaaaagc ctggcgggct atgaggccat tctgcacgac atccagcatc ttcttacagg 1149541 aaatatgagc gcgaaggctg ctgtagaaat ggctctatac gacggctggg cgcagatgtg 1149601 cgggctgccg ctttatcaaa tgcttggcgg atatcgagat acgctggaaa cagattatac 1149661 tgtcagtgtc aactcacctg aagagatggc agctgatgcc gagaattatc tcaaacaagg 1149721 ctttcaaacg ctgaaaataa aggtcggaaa agatgatatt gcaacagata tcgcccgtat 1149781 ccaggaaatc agaaaacgtg tcggatcagc tgtgaaactg cgtttagacg ctaatcaggg 1149841 gtggaggccg aaggaagcgg taactgccat tcggaaaatg gaggatgcgg gcctaggcat 1149901 tgagcttgtc gagcagcctg tccataaaga tgatctcgct gggcttaaaa aggtgacaga 1149961 tgcaacagat acgccgatta tggctgatga aagtgttttt acaccgcgcc aggcgttcga 1150021 agttctgcaa acccggagcg cagacttgat caatattaaa ttgatgaaag cgggcggcat 1150081 cagcggagca gagaaaatta atgccatggc ggaggcctgc ggggtggagt gtatggtcgg 1150141 cagcatgatc gaaacgaagc tgggcattac ggccgcggcg cattttgcgg caagcaagag 1150201 aaacatcaca cgctttgatt ttgacgcgcc gctgatgctg aaaacagatg tattcaatgg 1150261 cggcataaca tatagcggca gcacgatttc gatgcctggc aaaccgggcc tcggaatcat 1150321 cggggctgcg cttttgaaag gggaaaaaga gcaatgatgc acactgtcat atcagcagtg 1150381 gccaacatct ggacagcgcc tgattcacct cgtccgtctg atcaattcat gcttcaaccg 1150441 actgtaatga tcagagactg gctggagcgc atgacgtatg atgaacggct tggattatgt 1150501 acagacaatg taatccaaac tcaggttctc tttggcgaaa aggtacttgt gacggcggaa 1150561 cagggggaat gggtttctgt gatcgtgcct agccagccat cccgaaagga tccgcgcgga 1150621 tacccgggct ggatgaaaaa gtaccagctg gaaaaaacaa agcccatcca tacacaacac 1150681 gatgtgatga tcagcaaacc tgctgccttt ttgtacagaa gcaatgggga aaaggagatc 1150741 gaattaagct ttttgacagt tctgcccctt attgcaaaag aaaacggata ttttaaggtt 1150801 tcgaccgttt ttggggaaag gtttgtgagg caaagtgatg cagtgcctgt cagccaacag 1150861 aaagggactg ctgaagacat cattcaaacg ggtgcgtttt ttcttggcct tccctacctg 1150921 tggggaggga tcagcgggtt tgggtttgat tgctccggat ttatgtacag tatatttaag 1150981 gcgaatggat acagcatccc ccgtgatgcg ggagatcagg ctaaggcagg gaagggtgtc 1151041 ccgcttgatg atatgaaagc cggtgatctg ctgttttttg cttatgagga aggaaaagga 1151101 gcgattcatc acgtcggtct gtatgtaggc ggcgggaaaa tgcttcattc tccaaagaca 1151161 gggaagtcaa tcgaaatcct cacattaaca gagacaatct atgaaaaaga attatgtgcg 1151221 gtgcgccgct gtttttcaga ataaggaggg agacaaatga ggcgactgcc tttgttagag 1151281 gtcagccagc tgaaaatgca ttttgacgca gggaaaaagc ggacagtcaa agctgtcgac 1151341 ggggtcacct ttcagattcg tgaaggagaa acgttcgggc tagtcgggga atcagggtgc 1151401 gggaaatcaa ccttggggag agtgctgatg cgcctttatc agccgacaga aggaagcgtg 1151461 acataccgcg gcacaaatct tcatgcacta agtgaaaaag agcagtttgc cttcaaccgc 1151521 aaactgcaga tgatttttca ggacccttat gcttcactta acccgcgcat gaccgttcga 1151581 gaaattattt tggagccgat ggagattcat aatctctaca atacccataa agcacggctt 1151641 ctcgtcgtgg acgagctgct tgaggcagtt gggcttcacc ccgattttgg cagccgttat 1151701 ccgcatgaat tcagcggcgg gcaaaggcag agaatcggga ttgcgagagc actgtcgctg 1151761 aatcctgaat ttatcgtggc ggacgaaccg atttctgcac ttgatgtctc tgttcaagcg 1151821 caggtggtca acctgctgaa gcggcttcaa aaagagaaag ggcttacgtt tttattcatt 1151881 gcccatgatc tttcgatggt gaagcatatc agtgacagga tcggtgttat gtacttagga 1151941 cacatgatgg aaattacaga gagcggcacc ttgtatcgtg aaccgctcca tccctataca 1152001 aaggcgcttt tgtcctcgat tccgattcca gatcctgaat tggaggacaa gcgtgagcgt 1152061 attctcttga aaggggagct gccgagcccg gtcaatccgc caagcggctg cgtgtttcgt 1152121 acccgctgtc cggaggcgat gcctgaatgt ggagaatctc gtccccagct tcaagaaatc 1152181 gaacccggcc gttttgtcgc ttgccatttg tatcgaaatg ctgaaacgaa ggaaaaagta 1152241 agataaataa aaagagtggc tcctttttac tagagccact ccatttgttt atacttgatg 1152301 taaaaacttt acacaaaccg ggtaagggac agaaaccgtt gatgggagga gtgtcaatcg 1152361 gccggtttct ttgtctcttt caaacaagac aaggttgcct gtttcttcat ttgaagcaac 1152421 gaggaaccct tccgttgggt caaatacaaa gtcacgaggc cagtttcctt ctgtcgacac 1152481 tctttctacg aaagccagct ctcctgaata ttgattcact tcaaatacgg cgatactgtc 1152541 atggccgcgg tttgcgacat aaacaaaacg tccgtcctgc gtgacatgta ttgcgcttcc 1152601 ctggctgtta tctgtaaaat catcagggat ggcagaaacg acttggattt ctctaaattc 1152661 gccggctgtc gggttgtatt caagcgcaat cacttcattg cttaattctg tcatgacata 1152721 agcgtatttt tctttcggat gaaaagcgat atggcgaggt cctgcaccgg gagcgaagga 1152781 atggcttccg gattcagtca acacaccgtc tttaagctta taggtgtaga gcttatctat 1152841 acctaaatca accgctacca cataattgtg ttcaggtgtg aaccccgcgt agtgtgtatg 1152901 cggtttttct tgtctttcgt gcggcccttt tcctgtgtga gcggcctctg aaacaggtga 1152961 ttgcaagctg ccgtcttcct gaaccggaaa aacgtgtacc ttcccgctgt gataattggc 1153021 agtcagtacg aattgatttt gatcatcaac gcttacgtgg catggcgaag ggccatcaat 1153081 taactgatga ttcagaaatg tcaattcgcc gctgttttta tcgatttgat aggcagcaac 1153141 tccgccttgg ccgtctgctt tttcgatgga ataaaggatg gtgttgtttt tattcgtcgc 1153201 cacatatgtc gggttgccca gcttagcggc cagctttggc tcgctgagtg cttttttctc 1153261 agtatcaagc tcaaatgaat aaattccttc gcttccgcct tttgtatatg ttcccacata 1153321 tcctatgtat tttgtcatgc gatttccccc ttaaaaatga tgtcacctct atattaacgt 1153381 atcttgataa aataagctgt tcaaaacatg aaaaagggga agattcttca ttcgcctcga 1153441 atcagcggca ttgtgcagca cctgaaggag ccgcctgatt taataatttc tgacaggtca 1153501 atttcgataa tgtgatagcc tcttttcgat agctgttgat tgacatggcg gttgccaggg 1153561 agactgatga tcgttttttt tccgattgaa aggacgttgg tgccaagcgt aaattgttcg 1153621 tcctcgggca cctcaataag atcataacgt tttgccagca tatcggctgc atctggctca 1153681 atggcctgtg aataaattaa cgcttcgctt tcagatataa tgttaaatac gcagtccaaa 1153741 tgcaaaaatt tttcatgaag cttcactgga acgatcgtat attcaggaag tgcctcttct 1153801 agctggccga tagctgaaat gtcggtgcgc tggctgattc cgacatagac aatgtcatca 1153861 tcgataatga cgtctccgcc ttcaatactc gtatcaagca tgcgggtgta agagatacct 1153921 tggctgtgaa aaaaatcttt tataacggct tcttctcctt ggcgaatcgg ttcagtcatg 1153981 cttgacagaa aggctttttc tccgatgaca aatcctatgt ccctagtaaa aacctgttct 1154041 gggagtccgt cgcgaacggg caaaaggacg acctcaacgt tgtgtgacct aagtgcctcc 1154101 actaagcggc tgtgctggtc gttagcggtt tttacatgaa tattgtcatc ttcaaaatgt 1154161 ttttgtgttt cgtttataac atcttttatg gtcatgtgct caggtttgca taagatcact 1154221 ttttgaagtg tgccgtattc cgttcggcat accgttttgt gctgagattt cgggatggat 1154281 acgtccattt gtttttcctc ctaaagtgtg aagaatacat ttattattcc ctcatcatga 1154341 aaatcattaa accattttaa attttagaca aatggaagag aatattgttt aataggagaa 1154401 tataagtgca tttagctaaa agatcagaca tcaaagggga gaaaggtatg gaaacaccgg 1154461 aaacaagatt ttgtaaagag tcaaaggttg tgaaaaccag cagggtgttc ccgcttgaca 1154521 cgaacaacca taatacgctg tttggcggaa aattaatgag ctacatagac gacattgcct 1154581 ctatttcagc ggcgcgccat tgcagacgtg aaacggtaac agcttcaatg gattctgtag 1154641 attttttaaa gccgatcggg caaaaggatt ctgtctgcct agagtcatat gtgacatggg 1154701 tcggcacatc ttccatggaa gtatttgtga aagttattaa ggagcatttg atgactggcg 1154761 aacgggaact cgctgccaca tcctttttga catttgtcgc attagattca aatggcaagc 1154821 cggtgcctgt accgagggtt gtaccggaaa cagaagaaga aatcatgctg cataatacag 1154881 ctgtacagcg tgctaatgaa cgtaagaacc gcaagagaca cagccaggcg cttgcaaatg 1154941 cgctcggaac tgataagcct tggtgaacgt taaacccaaa acataagttg ttttgggttt 1155001 ttttgtactt ttcaatggtg attattacaa tggttagtcc gtttttgcta ggggattcta 1155061 taaaaaagca acaaatgtca tgttaaattg ataattttgt gacaacttta ttaaagattc 1155121 attttagata tatcttttat tcgtaagatc atgtatttta aagatatatt ttaaatacat 1155181 cttttcgaaa ggattgttta taaaatgtta gataacaaaa caatcgaaat tattaaaagc 1155241 actgtacccg tattgcaaca gcatggagaa acaatcactg gccgttttta cgatcggatg 1155301 tttcaagacc atccagagct tttgaacatt tttaatcaaa caaaccaaaa gaaaaaaaca 1155361 cagcgaactg cactggcaaa tgccgttatt gcagctgcgg caaacattga ccaattagga 1155421 aacatcattc cggttgtcaa acaaatcggc cacaagcacc gcagtatcgg aattaagcct 1155481 gagcactacc caatcgtcgg taaatatttg ctgattgcga ttaaagatgt attgggagac 1155541 gctgcaactc ctgacattat gcaggcatgg gaaaaagcgt acggagtcat tgctgacgcg 1155601 ttcatcggaa ttgaaaaaga catgtatgaa caggctgaag agcaagccgg cggctggaag 1155661 gagtataagc cattcgttat cgcaaaaaaa gagcgggaaa gcaaagaaat tacatccttc 1155721 tatttgaaac cggaagacag caagccgtta cctgaattcc aagcagggca atatatcagc 1155781 atcaaagtgc ggattcctga ttctgaatat acgcatatcc gccagtacag cctgtctgat 1155841 atgccgggaa aagactatta tcgaatttca gtgaagaaag atggtgtcgt gtcttcctac 1155901 ttacacgatg ggctgcagga gggagattca atagagatca gcgcaccggc aggggacttt 1155961 gttttagatc atgcatcaca aaaagatctc gttttgatca gtgccggagt tggcattaca 1156021 ccaatgatca gcatgctgaa aacatctgtt tccaaacagc ctgaacggca aattctgttc 1156081 attcatgcgg cgaaaaacag tgaatatcat gcattgcgcc atgaagtaga agaagcagca 1156141 aaacattctg ctgttaaaac agcatttgtg tatcgcgagc cgacagagga agaccgtgca 1156201 ggtgatctgc attttcatga aggacagatt gatcagcaat tcctcaaaga actgattgcc 1156261 aacacagatg cggattacta tatttgcggt tcaccgtcgt ttattacggc aatgcataag 1156321 cttgtatcag agctcggatc agcgccggag tctatccatt acgagctatt cggcccgcaa 1156381 ttaagtttgg cgcagtccgt ttgaacacat acatgaaact cttctccttt cagagaagag 1156441 ttttttattg agatataaga aggcagacaa gcgccggttt ctacatccgg acaatcacag 1156501 acccgctgcc atttgtgcat acacggtttt gctgttcttg cattgttctc agcaattcat 1156561 tgtttacctc aatcgctcta attagttgct tcattcttag ctccaaaccg gccagcctgt 1156621 cgattgtttg ctgctggtag ccctcgggtt ggggagccaa tggcagatca aagggccaaa 1156681 gggtattcga cttctgattt ttcatattgc gtattgcgcc tccaatcggt gtcactttct 1156741 attatgttat gttcaggcga tatgcacgtt cgcctagaca ctgatgcata gagggcctgc 1156801 cacggggcac aataggctca atatgaccag cggatggagg taaagatcgg tgttatggat 1156861 ggtatgggta tttttactga agccagttat cgtattttcg attgcatata ttttgtttcg 1156921 gcttgccggt aaaaaagctg tgtcacaaat gaacaatttt gacctgcttt tgaccttcgc 1156981 aatcggaacc attatcagtg agccgatcct tacatccaag ctgccgatgt caatttatta 1157041 tgcgggtgct tttttggtgc tttatcttat catgagcaag ctctctttat ctaataaatg 1157101 gcgatggctc ctagtcgtga gcccgactgt cctaatccga aacggggata ttgatgaacg 1157161 cggccttcgt aaagaaaggc tgactgttaa tgagctgctc ggaaagctga gggaaaaggg 1157221 ctatgccgac ccggctgaca ttgatcttgc tatcattgaa gaaacgggag aagtaagcgt 1157281 catcccgaaa gaggaagcga gagcggtgca ggtgcgggat ttgaatatgg aagctgaacg 1157341 gaattttatc ccgattccgc tcatactgga tggcgaaatc cttgatcata atttgaaata 1157401 tctccaaaaa aaccgatcct ggctgtttga gaagcttgag gaaaaagggt acagccccaa 1157461 actgctgtct tcgattatcc ttggcacgat gaatgcacgc ggtgatatat cccttgattt 1157521 aaataccgct aatgaaccgc agcatgatcc ttacttatat aaaccgggaa ataacaatta 1157581 agatggctct ctcttgtaat gagagctttt ttctttttta aagggaattt ttgtttggtg 1157641 tcaaatgtac ctagttagga ggggaactga acatgaagga cttatccata agaaacgaca 1157701 tggcgccaac ggtcagtttg ctgtattccg cagtggaaga aaacagtctc cgtctggctt 1157761 ccatcgtaag ccatatgaca cacagtgaac tttactataa ggggcgctgc caaacaaaaa 1157821 acagcacggc tcagcttttg caccatatca caaatgttga tatcagatgg gtctggcgta 1157881 tcaaggaaaa tcggatcccg gaccatattg aacaggcata cggcccgatg acagatgaaa 1157941 gcggacggct gcctgaaccg gtgaatcagc cagacttaga tgaactcctg aaaagacatc 1158001 agcatgtagt agagaagctg aaatcggtat gcttcacttt aactgaaaat gctttgaacc 1158061 agccgctttc cttcgaaggt gacaccgcga cgatacgatg gggaatttgg catatggcag 1158121 atcataaccg ctatcatcag gcacatattg aagctctcaa aaaagaatgg aagcaggatg 1158181 tggcgaagta tgaacgctaa aacgaagctt gtgactgatc gaattcgttt gcgctgtatg 1158241 gaagatcggg atcaagccac tttgtttggg ctgcttttta atgatcctga cgtcatgaca 1158301 tattattccg gtttaaaaga taagaggcaa acccgcgagt gggtcaattg gaaccaacga 1158361 aatgaaaaag ggtacggcgt tagtctgtgg atcgccgaag ataagcggac aggggagttt 1158421 ttggggcaat gcggcatcgt tccccagcag atcgaaaatc aaaccgtaat ggaaattggc 1158481 tatatgtttg cccgccgcca ctgggggaac ggctatgcgc aagaagcggc tcgggcctgt 1158541 ctggactatg gctttaacga gcggcagttc ggcaaaatgg cggctttgat tgatccgggt 1158601 aacaaagcgt ccatacgggt agcggagaaa atcggcatgc attacagcaa aacgatcaga 1158661 aaatggaata aaccgatcgc ggtatatgaa agaaaatctt acaattgaaa gatagagctg 1158721 agtttagtat catgatatca tgtaaagttt tctagggttc cgcatgtcaa ttgacatgga 1158781 ctggtccgag agaaaacaca tacgcgtaaa tagaagcgcg tatgcacacg gagggaaaaa 1158841 agcccgggag agtcaatctc atgtgagacg actgtccggg gtttttttgt tttcggagaa 1158901 tcttaataga tagaaaggaa tgactcaaaa tgaaatgggg attggtcgtg cttgccgctg 1158961 ttttcgaggt tgtttgggtg ataggcttaa agcacgctga ctcagcctta acatggagcg 1159021 gcactgccat cggcatcata ttcagctttt accttctaat gaaggcgact cacagtctgc 1159081 ctgttggtac cgtgtatgcc gtctttaccg ggctcggcac agcgggaaca gtacttagtg 1159141 aaatcgttct ttttcatgaa ccggttggat ggccgaagct attgttaatt ggcgtgctct 1159201 taatcggtgt aatcgggttg aagcttgtga cacaggatga gacagaggaa aaaggaggcg 1159261 aggcataatg ctgcactgga tcagtttatt gtgcgcgggc tgtttagaaa tggccggcgt 1159321 ggcccttatg aatcaatatg cgaaagaaaa aagcgtgaaa tgggtgctgt tgatcattgt 1159381 tggttttgcc gcttcatttt ccttgctgtc gtacgcaatg gaaaccactc cgatgggaac 1159441 ggcttacgcg gtctggacag gaattggcac cgccggcggg gcgcttatcg gcatcctctt 1159501 ttacaaggag cagaaagacg ccaaacggat cttctttatc gcgttgattt tatgctcagc 1159561 agttggttta aaaattctgt cataaattga tttttatcaa atcttcagta taatggataa 1159621 atagtttaga cttacaaaga taagagggat tattcatgaa atcatatatg actcagcggt 1159681 tggacgaata ccgtgacgga aatgaggata aaggtcggct cttggtcagc tgccccgatc 1159741 agccgggtat cgtctctgca gtttccgcgt ttttatttga acacggtgcc aatattatag 1159801 aatcaaatca atatacgaca gaccctgaag gcggccggtt cttcctgaga atcgaattcg 1159861 actgcgcagg cattcgtgaa aaaaaatcat cacttcaggc agcgtttgcc tctgttgcgg 1159921 aaaaattcga catgacatgg agcttaactt tggcgagcga actgaagcgt gtcgccattt 1159981 tcgtttcaaa ggagctccac tgcctgcatg agctgatttg ggaatggcaa accggcaacc 1160041 tgatggcgga gatcgctgtt gtcatcagta accatgagga agcgagagag ctggttgagc 1160101 gcctgaacat tccattccac tatatgaaag cgaacaaaga catcagagcg gaagtcgaaa 1160161 agaagcagct tgaactgctg gagcagtacg atgttgatgt gatcgtgctc gcacgctata 1160221 tgcagattct aactcctgat tttgtttcgg ctcatccgaa tcgcatcatc aatatccacc 1160281 attcattcct gccagctttt atcggtgcga atccgtacaa acgggcctac gagcgcggcg 1160341 tgaaactgat cggtgcgaca tctcattatg tgacaaacga tcttgatgaa gggccgatca 1160401 ttgaacagga tattgagcgt gtggaccacc gcgataatgc ggaagcgctg aaaaacatcg 1160461 gaagaacaat tgagcgcagc gtgcttgccc gtgctgtgaa atggcatttg gaagaccgtg 1160521 tcatcgttca tgaaaataaa acaatcgtct ttaactagac tgcaagaggc ccgcgcaatg 1160581 cgggctattt ttgatgacaa aaaaccttga caagtgtctt ttttctttgc ataatataaa 1160641 aaaatcattg agcgttgaag aggattagta agcagacctt tctgtgacag agagcaaaat 1160701 gaatcgctga aacattttgc cgcatgaaac ctgccgaacc tgccttggag tcctaggggg 1160761 aaaacctagg cgcataacct ggcgttacag gagagcggag cgtgcacaag cgcgttcaat 1160821 caaggtggta ccacggaaac ccatttcgtc cttatgaatc aggatgaaat gggttttttt 1160881 attgtagaag agccgcggag gagaataaat gaaaaaacaa agaatagtag tgaaaatagg 1160941 aagcagttcg ctcacgaata gcaaaggaag cattgatgag gcaaaaatca gagagcatgt 1161001 tcaggcgatt tccgtgttaa aaaaagcggg gcatgaaatg attctgatta cctcgggtgc 1161061 cgtagcggcg gggttttcca gcctcggtta tccatcccgt cccgttacca tcaaaggaaa 1161121 acaggcggcg gccgcggtcg gacaaacact gttaatgcag caatatatga atcaatttaa 1161181 acaatactca ctgactccgg gacaaatcct tttaacgaga aatgattttt cgaaaagaga 1161241 acggtatcga aacgcgtatg ctacgataat ggaattatta gagcggggcg tcattccgat 1161301 tatcaacgag aacgattcta catctgttga agaattgaca ttcggagata atgatatgct 1161361 ttctgcgtta gtcagcggat tgattcacgc ggaccagctc atgattctca ctgacattaa 1161421 cggactgtat gatgccaatc caaatgaaaa tcctgaggcg aaacgatttg attatttgcc 1161481 agagatcacg cctgaattgc ttggatatgc aggttcagct ggatcaaagg tcggcaccgg 1161541 cggaatgaaa tcaaagctgt tagccacaca aaccgcgctg tctctgggag tgaaagtatt 1161601 cattggaact ggcagcggag agcaaaaact tgcggacatt ttggacggca ggggagacgg 1161661 cacttatatc ggagacaaag aactatcttc ggttaacaac acaaggcagt ggattcagtt 1161721 ccactcgccg atatcgggag aaattatcat tgatgcgggt gccgaagagg cgatgatcca 1161781 taatggaagc agccttttgc ccgctggagt tgtgggcgtg aacggaagct ttccgaaagg 1161841 ggcggttgtg gaagtcaggg gaccgggcgg cgtgatcggc aaaggccaaa ctcattactc 1161901 ctccgaggag attatggagg ctaaaggcaa acgcagtgac gaacttgatt ttgagaaaac 1161961 gtttgaggtt attcatagga atgactgggt caatgtaaaa gactaggagg cggaaaaatg 1162021 agtgaagttt ctgtaaaagc gaagctggcg aaagaagcag cagccgaaat gatcatgaaa 1162081 acaacagccg agaaggatga ggcgctcagc ctcattgcaa acggactccg caaagaactg 1162141 gattttctct tggcggagaa tgcaaaagac attgtgaacg gaaaagagaa tggtttaaca 1162201 ccggacatca ttgaccgtct ctcattggat gagaaacgga tacgcgatat cgcggacgcg 1162261 gtggagctct taatcgactt agcggaccca atcggcgact ctcttgaaac gattgaaaaa 1162321 gaaaacggcc tgtttattga aaaaatccgt gtgccgctcg gtgtcgtagg aatgatttat 1162381 gaggcgaggc caaacgtcac agttgatgcg gctacccttt gcctgaagac agggaacgcg 1162441 gttgtgctgc ggggaagctc ctcagccatc cacagcaaca aagcgctcgt cagtgtcatt 1162501 tacagagcac ttgagcaatc agcgcttccg attcacgctg tgcagctgat tgaggatacg 1162561 agcagagaga cagcaaaaga gctctttacg ttaaatgatg gcttagacgt attgattccg 1162621 cgcggaggca agaaactgat tgatctcgtt gtgagagaat caacagttcc tgtattagaa 1162681 acgggagcag gaaactgcca catattcatt gacgaaacag ccaaaccgca aatggcagaa 1162741 aaggttgttg taaatgccaa aacgcagcgc ccttctgtat gcaacgcgat tgaatcattg 1162801 ctgattcaca aggcttgggc aagacagcac ggaaaagaat tgctggacca gctggaaaac 1162861 gcgggagttg aaattcgcgg tgatgaattg gtatgtgaac ttcatccttc aagcaaacaa 1162921 gcatcaaaag aagattggga aaccgaattt ttagcgcctg tcctcagcgt aaagacggtt 1162981 gaaaacgtcc aagaagctgt aaagcatatc caacaatacg gcaccaatca ttctgaagcg 1163041 attttaactg aaaatgacaa aaatgcggta tattttcaaa cggctgtcga tgctgccgct 1163101 gtctatcata acgcgtcaac ccgctttacc gacggctttg aattcggcta cggagccgaa 1163161 atcggcatca gcacgcaaaa gcttcatgca agaggaccga tggggcttcc tgcactgact 1163221 tctacaaaat acatcattaa aggaactggg caaatccgtg aatagcgggg taatgttcaa 1163281 tgaaaaagct tatctcatta cgagataagc ttttttatac gcgaaaaatt gacatttcaa 1163341 atttaattgt gtacaattta attgtataaa atatattggg ggaatgaaaa atgagtcagc 1163401 cattatttac cgcaactgtt tcagcggtag gaggaagaga aggaaaggtc atttcatcag 1163461 accgcgttct tgagcttgat gtcgcaatgc cggggacacc gagagccaag aaattagaaa 1163521 aagcgacaaa tccagagcag ctgtttgcag caggttatgc agcttgcttt gacagcgccc 1163581 tgcagcttgt cgcaagaaca gaacgggtaa aagtagagac agaggttaca gcaaatgtta 1163641 gcctgttaaa ggatgaagcg gaccagggct ataagctggg tgtgacgctg caagtaaaag 1163701 gagaaggagt cagtgcatca gaattggagg cgcttgtgaa aaaagcgcac ggcgtctgcc 1163761 cgtactcaaa agcaacctcc ggaaatattg atgtgacact tgaagttgct gaataaataa 1163821 aaagaggatg cctgtacaag gcatcctcaa tttttttgat gaagtgtttc cagtaatgta 1163881 tatagagcgg actttaactg tttgagatcc tccccagact gctttgagag ccccagaatt 1163941 gtccctggaa tgtcaaccgc tttttctttt aataacgctc cgtcctctgt caggctgatc 1164001 aacacggacc gctcatcctc ttcagatctt tttctcgtaa tcaaaccctg ttgttccatt 1164061 cgtttaagca tcggagtgag cgttcctgaa tctaaataca gctgttcgcc catttttttg 1164121 acagtaagcg tttcatgttc ccataacaaa agcaaagcca aatattgagg gtatgttata 1164181 ttcagcttat caagcagcgg cttgtattgc tttgtcatct cccgcgaact cgcatatagc 1164241 aaaaaacaaa gctgattctc caatttcata tgatcaaatt tattttccat tttgttcacc 1164301 aactcttttt tgtcattcga ttctattgta tctgaaaaac ctcacttttc ctattctcgg 1164361 caaacatagc atgtttaaaa agatcagaaa gggaaatata acaactagat acaaataagg 1164421 aggttgggaa atatggcact atttacagca aaagtaaccg cgcgaggcgg acgagcagga 1164481 catattacat cagatgacgg tgttcttgat tttgatattg tcatgccaaa tgccaaaaaa 1164541 gaaggacaaa ccggcacaaa tccggaacag ctctttgcgg cagggtatgc tgcatgcttc 1164601 ggcggcgcgc tcgaacacgt agccaaagag cagaatatcg aaattgattc ggagattgaa 1164661 gggcaggtca gcctcatgaa ggatgagagc gacggcgggt ttaaaatcgg tgtcacactt 1164721 gttgtgaaca cgaaagattt agatcgggaa aaggcacaag agcttgtcaa cgccgctcat 1164781 gaattctgtc cttactcaaa ggcaaccaga ggaaatgttg atgtaaaact agaattaaaa 1164841 taatgaccgg catcctgagg attctcagga tgttttttgg tgtcggacat gcggggcggg 1164901 cacagattta tgataaaact tcagagaagc gtttgaagca tgcctttaaa ccaaaagtta 1164961 cagatgaagc gggtggctgg cacggtgtct gccgtgctga attgcgcgta tatgctgttt 1165021 tgtatttgca cagggcatag cggctacttg gagaaataac aaggaccagg ccgcgcatgc 1165081 ctgatccttt taatattctt tcttattggc gaagttccgc catgcttgaa acggggataa 1165141 atgctctgtt agtgtcactt gataaaaggg gatcgttctt tcttcagcag gtttatcaat 1165201 ttctttataa atgaatgaat catcaaaccc ggcttcggca gcgtctgtgt gctcagctgc 1165261 atagaaaacg gctttaggcc gggcccagta gatggcgccc aagcacattg ggcatggttc 1165321 acagctcgta tacaaaatgc agtcatcaag ctggtaggct cctagcacct tacaggcttt 1165381 ccgaatagct gtgacttccg cgtgggcagt cggatcattg cttgttgtga cgttgttctg 1165441 tccctctgca ataatggctc cgtctttcac gataacggct ccaaaaggcc cgccgattcc 1165501 tgcattcact ccttcacatg cgagagtgac agcccgtttt aagaacgttt catgattcat 1165561 cccaatccct cctgtcaata gagtgttatt agtatagccg aaaagaatgc aaagaacatt 1165621 cttaaaaaag tgcaaaataa acaaagtatt tgggggattt gctaaataag aaaccgattg 1165681 tggctgtatt atagaaaaaa accatctgcc aaatgcagat ggttttttca aattatacta 1165741 gctgtgtctg ctgtgctctt gcctgttttg cggcttcaac catatttttc aatgctgcaa 1165801 ccgtttcttc ctgctgtctt gttttcaatc cgcagtctgg atttacccag aagcggtcag 1165861 tcggacagac ggcaagcgca tcaacgataa tattgtacat ttcttcagtt gacggcacac 1165921 gagggctgtg aatgtcatat acaccaaggc caagcccttt caaatacggg tggtttttta 1165981 agtaatctaa aaatcctccg tggcttctgc tatgttcgat tgtaatcaca tcggcatcaa 1166041 gatcattgat tgtatcaacg atatcttcga agttgctgta gcacatatgt gtatgaattt 1166101 gtgtctcgtt tttcacggaa gaagtggtta atctgaaagc ttctgccgcc caagtcaaat 1166161 actcatccca atcgcgggtt ttcaatggaa ggccttcacg cagcgctggt tcatcgactt 1166221 gaatgatttg aatgcctgcg tcttcaagcg ctttaacttc tttgcgaagg gcaagcccga 1166281 tttggaaggc gatttctttc ctcgagatgt cgtttcgagg gaaagaccag tttaagattg 1166341 taaccgggcc cgtcagcatt cctttcacat gcttggaagt caatgactgt gcgtagactg 1166401 tgtctttcac tgtcatcggt tcaataaatt caacatctcc gtaaatgact ggcgggcgga 1166461 cacagcgtga gccgtatgat tgaacccagg catatttagt gaaggcgaaa ccggccagct 1166521 tttcaccgaa gtattcgacc atgtctgtcc gttcaaattc gccgtgaaca aggacatcaa 1166581 gctccaattc ttcctgaata tcaatccatc tttttgtttc cgcattgata aagttttgat 1166641 actgttcatc ggaccactca gctttccgcc atttttggcg tgcgctccgc acttcagcag 1166701 actgcgggaa gctgccgatc gttgtcgtcg gcaaaagcgg aaggccgaga gattcatttt 1166761 gtagggctaa acgttcttca aacggaatcg ggcgcttgaa gtctttatca gttaattgct 1166821 caagctcttt cttttgttca gaattggcgc ctgttgcaaa ctgtttaagc gcctggatat 1166881 cagccttagc ctgctgaatc tcttcgctga tcgccgcttt tcctgatact aagccttctt 1166941 tcaaagctgt cagctcggcc agcttttctt ttgcgtagga taatccgttc aataggtctt 1167001 tttccaaatg ctcatcaggg tgtttcgcta ctggaacatg cagcaggctg ctggaaggct 1167061 gaatccacag ttcatcaact tttgcaatgc tgagaatatc aagaacggca tcgagacgct 1167121 cttcaaggtc cgctttccaa atgttgcgtc cgtcgataac gccggctgcc agcactttat 1167181 ctgtcgggaa gccatgtgtt ttaagctgtt ccaggtttct gcctttgtcg tgaacgaaat 1167241 caaggccaat tccctgaacc gggtaagaga tcagctcttc ataagcatca acagaatcaa 1167301 aatacgtctg caaaagcaca ttcaaggatg aaagctcact tgtaatgctt tcaaataatt 1167361 cttttgcgcc gcgtacatct tcactagagg cggtaacgag cgccggctca tcgatttgaa 1167421 cccattttac gccttcttct tcaagctctt tcaaaagctg tacatataat ggcacaaggc 1167481 gtttttggat cgcttttgct tcagacggtt catagccttt agcaagcgta acgaacgtat 1167541 aagggccgac aatcacaggc tttgtttcca caccgtattc ctgtttgatc cggcgataat 1167601 cttcgagttg tttgtttctt gtcagacgga actcaatgct ctcgtcatat tccggaacga 1167661 tgtaatggta atttgtatta aaccattttg tcatttcact agatacagcg tctttgattc 1167721 cgcgggcgat agcgaagtat gtatcggtag cgtcagtcaa atgtctgaac cgtttcggga 1167781 tccagttgaa gctgactgct gtgtcgagta catggtcata ctgtgtgaaa tcagaaacag 1167841 gcacaacatc aatctgctgg tcaatttgtg tttttactgc ggataaaaat agttcgtcga 1167901 tttgcttcaa aaacgtatct ttatcagtac tgcctttcca atacgcttca agtgcttttt 1167961 tccattcccg gttcagtccg attctcggaa atcctaaatt cgatgttttg atggttgtca 1168021 ttgtttctcc tcctttatat gtaaaacact ctctttcacc cgcggataca ggctgctaag 1168081 aggttttctc acaacaaaaa gcctctttcc catgagagaa agaggctttt ctacgtaaaa 1168141 cactgcctct ctcatctctc agacacaatc tgatggaatt agcaccgtgc cttatgagac 1168201 atcagtctcg gcgcgaaaag cagtgcgccc catttcacaa tggtattacg gtcggttgct 1168261 gttggggtca aaaggccaat ccctcgccca actctcgata agagaaaatg ttattaattt 1168321 tttgaaaagt tgaatcattt gttggtaatc ttaacagtaa ttcaaattca ttgtcaacat 1168381 agaatttgaa atttttattt acatgatgtg gtgtatatta tataagaaaa ataatcttat 1168441 agggtcaaca aatgtgattg ctctgctttt tctgcgagct catcaggagc tgttaaatac 1168501 aggaatccat tgcctgccag cgtttttgca atatcaagag gaagtgtcct gcggattagc 1168561 tgtgcgaaaa cctcagattc agaaagcttt ctttgaaatg attcttcttc atagcttttg 1168621 attaaagcaa gcgcaccgct gacatgaggg gcagccattg aagtgccggt cagcttaccg 1168681 tacttcttgt tgggaagggt ggataagatg ttttctcctg gtgccacaag gtcaatctct 1168741 ttattcgcgt tagaaaattc tgataattct cgcgctacag aaacagatcc aactgcaatc 1168801 acttcattat aagctgcggg gtaggaaagc tcttctgtgc gttcgtcgcc gtcaccttca 1168861 tttcccgctg cacaaacgac aagcactccg tttttcactg cgtttttcac tgcttctttt 1168921 agctctggca catcgcttgg ccctccaagg gacattgaga tgatgtcgac tttctgttcc 1168981 accgcgtagt tgatgccgtt aattatccat tcgtattgtc cgctgccgtt ctcgccgcca 1169041 agaaccttca caatcaatag gcttgcctca ggcgcgactc cggcaatgcc tccgtttgaa 1169101 tcattagctg caattgttcc ggcgacgtgt gtgccgtgtc cgttgtagtc ggaaatcgca 1169161 tcttccttgc cgccgtcgtc atccgtgaag ttctttccgc cgatgatttg attttttaaa 1169221 tcagggtggc ttgtgtcgca gcctgtgtct aatacagcaa ctttaatatt tttgcctttt 1169281 accccttttg cccacatttc tggcgcctta atcactttaa tgccctcagg aagctcgttt 1169341 acatccatga tctgctcatt cgtcacatac gggatcaagc ggatttcacc attcataaaa 1169401 aagccctcct tttttatgct tgcaagtgga ttcaagggtg ttgcctcata ttatatgaaa 1169461 aaagcaagcg ctcggacaga gccatttgaa gcattttgaa aaaataggat acacaccaaa 1169521 gaattagtaa tcttcaaaat attggatggc ttcaacatgt atgactggga ttcaactgta 1169581 agtcaagtta taatagtgtt ggggaaagga gcagtgtcat gaaactgaat gaaaaattat 1169641 atgcattttt ttcagagcat gtggaacaaa tggccgagga atggattgaa acgatggagg 1169701 aaagtgatcc gaattcgctt tacgccctac ataatgcaac agtaacggaa gaattgaaag 1169761 agcaggacag agaattttac cggcatctga attacatgta tgttttaccg gaaaaacaat 1169821 ttctcgaaga gtttcaagag tgggtcattg agctgaccaa cgatcaaaaa catctcgaca 1169881 caccggttca gtatgtcatt cgggagttta tgagaaacag gagattatat acgaagtatt 1169941 ttgagaagtt cgcagaagaa aatgaatcag cgtttgaacc gggagagaag caaaaatggg 1170001 cagatttgat tgtaaaagta tttgatttca ccatttatac attcgttgat cacgctgaaa 1170061 tgaatgccaa gcagcaatta aacgcccaaa gagaaatgat attggaatta agctcacctg 1170121 tcattaccct gagcaaatca acagctctgc tgccgcttgt cggtgacatt gataccgaac 1170181 gggcgaagtt tattctggaa aacacgcttc aagcttgtgc gaaaagacgt gtggagcatc 1170241 tgttaatcga tctgtcaggt gttgttgtgg tggatacgat ggtggcgcac cagatcttta 1170301 aattgattga ggcgcttaat ctgatcggtg tccggtcaac cctgtcagga atcaggcctg 1170361 aaattgcgca aactgctgta cagctgggga ttgacttttc gaatattact attaaaacca 1170421 accttgccca agcattaaac tatcatcaat aaaaaaatcc gctatctgtg atagcggatt 1170481 ttttatgatg cgaaacataa agatacgaga aaggatcccg cgaataataa gaggacgagg 1170541 caaaagaaca cccagtcgcg ccggttcacg ctcaatgtcc tgtagtatgt ccggtttctg 1170601 cttcctgtaa atcctttcga ttccatcgca agcgctgtcc gttccgcttt tctgatggcg 1170661 cttgccaata gcggtatggt atatcgtttt aacgcactga ttttattaat gatgccgctc 1170721 tccgccgctc ctcctctgat tttatgagcc tgctgaatca gctggacctc atcctttaac 1170781 agcggaagaa agcgaaagcc tgcaatgaca ccgtacgcga gctttggtga gagcctgcac 1170841 tgctggacaa ggctcagcat aaatagaatc ggatcggttg taaaaacaaa catcatcgat 1170901 aaggcggaaa agcataaaat acgaaacccg agagagatgc cgacagacac attatcgctg 1170961 ttaatggaga tagggcctgc ttgaaacaaa aaattatccg gtgttgtcgg cacttttcca 1171021 aaaactgcgg ctgtccacac gcatccgaat gctaaaatca aaaacggaat cgtaaacaac 1171081 aaccattttt tcaatgggat tccggccgcc agtaaaacgc ccgcaacgat gatgatataa 1171141 aaacatgccg gagtgtaagg gttgtaaata aacgacagca tgacgacaca acaaaaaacc 1171201 gccgccgctt tcacagtcgg attaatgaga tgtaacggtt gcttcatcac gcacctcctc 1171261 ttgaaatgcc atccattcat atagaagggg aagggtgagc tttgcttttt gaacaagccc 1171321 tgtttcttga gaaaacaact gcgctggaga tccgtcaaag gccaggcctg tatcgtgaag 1171381 cacaagcacg ctgtcagcat acgaagagac tagctccata tcgtgtgtaa tcataaggac 1171441 agcagttccc tctgccttga tacgttgaat catttccatg cattcagccg ccgtgcgggc 1171501 atcctggcca aaggttggtt cgtctaataa taaaaccttt acgtcatgca tgagcatagt 1171561 agctacgctc agtcgccgtt tttgcccttg gctgatcgca aacggatgat gatcagccaa 1171621 atgcgcaaga ccaaaacgct gcagcaggtg ttgcgctttt ttctcagttt cagcatttgc 1171681 tttctggccg aacagaagct cgtcatacac cgtatcggtg acgaattgat gctcagggtt 1171741 ttgaaaaaca aatcccatcc gtttacgcaa ttctttttct ttatatttct gcagcggctg 1171801 atcatagaga aggattttgc cgctttgcgg tttcatgaga ctggccagaa ctgataggag 1171861 cgtcgatttt ccagttccgt tcggaccgac aagcgccgtt aaagagcctt cgcgcaacga 1171921 aaagctgatg tctttgaaaa tcgcctgctg tcctctcgcg aacgaaaggc tgctgacttc 1171981 aagcacactc tccccagaag gggctttctt ctttttgaca tgcccggcag gaataggctc 1172041 tttgaacagc atctcttttg ataaagtaaa cggcatactc agcttttcct gcagatgaca 1172101 gacctttgga atggcgatgc ccaatttctt tagtgtctcc gcttcatgct gaaatagatt 1172161 tttcgtcagg ccatccagtg cctttttgcc tgatttgtcg agtacgatcg ttctctcaat 1172221 ccaaggcgcc cattcatcaa gctggtgctc aatgacgagg aggctgaaac ctttttcccg 1172281 ctgaagatcc ttcatcagat gaacgaactc ccgagctgag aaagggtcta aaagagaggt 1172341 cggctcatct aaaataataa gctcaggctc catcgccaaa atacaggcga gagccacttt 1172401 ctgcttttgt cctcctgaaa gggttgagat cattttttct tttaaatggg taatgcgtaa 1172461 tttttctaat acggcgttga ttttctctgt catttcttct tttggaattt gcagattttc 1172521 cagcccgaac gctatttcgt cctccaccgt cagcatgcag aactgctgat caggatcctg 1172581 aaaaacgacc ccggcatgct gagtaatcgt ttcggaggtt tcagcatctg tgaccggctt 1172641 ttgaaataga aatacatgtc cggactgaat gccgtcgcaa gcctccggat atagaccgtt 1172701 taaacaaagg gcgagcgagc ttttaccgca tccgctcggt cctaataata aaacacattc 1172761 tcctttttga agctcaaacg aaatgtcttg aaaaaccggt ttctcgtctt cttcataaga 1172821 gaagctgagc tgctcaaccg tcagaagctc atcaaaggct tgcatgttct gacgcccgct 1172881 tccgtttctt tttcagttcc tttccgagtg ccattccgtt taacacacct gtataagcga 1172941 gagagtcgct gacagctttt ccgagaagcc ccgccaaaag cgcgccggaa atgaggcgga 1173001 tcacaagcat aatgagcaga taacctggtg aataggctgc atagccagaa acaaagagat 1173061 catagataaa gctggctact gaagacccca taccggccag cataaggaca gggagagagt 1173121 atgctttcca gcgtgttgca agaaatacag cctcagcccc gagcccttga acaatgccaa 1173181 tgacgatgac catcgggcca gacggatttc ccagcaggca ctcaacgaga gcggcaatga 1173241 tttcagaaac gagcgccgca cccggttttc gaatcatgta cgcggcgatc acagaaacga 1173301 taaaccaaat gccgtaaatt ggttcatagg cgattggccc aaacatacct gcaagtacgt 1173361 ttccgaaatg tgtaaataat aaataaacaa cggcaaatac gatactgata acggacatga 1173421 tgacaatttc ttttactttc cagcttttca tgttatccct gctttctgtt ttttcttgat 1173481 ggactgttag ccgaaagatt cacagtcatg gtgatgtggt ttgtttgctg ctcagccatg 1173541 cggaaaacgg cctccaatgt gctgaatacg tcatgcgcat ccccgtcaag ctcgctcgcg 1173601 taatggacac cctgtacgaa agtgccttgg gcttttgcaa tgtcgacagc ctccataatc 1173661 aatcccatat aatccggctc attcattgga taaagggcaa attggcacgg cgcttccgcc 1173721 ttcaagcctc ggacagcatc ttcattgaca cgcttatcac ctttggaaag atatgtatcc 1173781 ccctgtgtgt cacccgggca tccaatggaa aacgtgccgt tcatgacgat gtgttgttcg 1173841 ctgtttgctg catgaaggta aatggctttt gcagcatcga atacatgatc aatcgatccg 1173901 cgtaacaccg tgctgatatg gtcggttttc gtccaaacct tggatgtatc tgtttttttc 1173961 agcgcagact tgatcacact gataaaatca tccgtcatcg gatataaaga gaagcgaaaa 1174021 ccggcgattc tgcttgtacc gcaaatatgc tccatttctc cgacctcctg tttttttggt 1174081 aaaataaaaa actgcatatc ctaagggaat atgcagtcat agatcgatta agcgcacaaa 1174141 aaaatacacc attcggtcaa cctgcacttc cccacgctgg tattatccag atcgggtcat 1174201 aagggatcaa agcgcgtttc ttccgcgctt tatctcagcc aaaacagcac ccctagtgct 1174261 ttccgtatac aattttttat tttgacatca taatagatga taagaatcat tttgtaaaca 1174321 acgaaatcat ttttttcata tagggacggg agaggatggt caaatttgga aaaaggacac 1174381 atattaattg tggaagatga agaaaaaatc gccagggttc ttcagcttga attggaatat 1174441 gaaggataca gcgtcacgat caaacacaat ggcacagaag gtcttgatgc ggcagcggaa 1174501 ggcgggtatt ccttggtgct tcttgatgtc atgcttccgg ggcttagcgg actggaagtg 1174561 ctgcgccgct tgagaaaaac ggattcgcag acaccggtca tattattaac ggcgcgagac 1174621 agtattcctg ataaggtaac aggtctggac atcggtgcaa atgactatgt caccaagccg 1174681 tttgaaatcg aggaattgct tgcgagaatc agggcggcgc tgcggcaaaa tggaacaaaa 1174741 actgaagata tcggcacctt tcttacatat gacgatttgc gggtgaacga aaaaacccgt 1174801 gaagtgagac gcggagacaa agaggtggaa ttaacgccgc gggaatttga tctgctcgtc 1174861 tatatgctaa agcatccgca gcaagtgctg acacgggagc aaattctaag ctcagtatgg 1174921 ggatttgatt atatcggtga tacaaatgtc gtggacgtct acataagata catcagaaaa 1174981 aaactggact atccttacga aaaacagctg atccatacga ttcgcggggt cggctatgcc 1175041 attaaggggt aaacgatgaa gctgaagacc aagattcatc tatacacttc gatatcactg 1175101 ttgattttat taattttggt tcataccgca gtatatctca ttttttcgtc tgcgctgaca 1175161 tcaaaggatg cggcccggct tgctgatgag acggataaca ttgccgaagc gctgcgtgcc 1175221 gctgaaacag aaggagtggc tttgcaggat atgctgcagg cctatcttcc ggcaaatggc 1175281 atggtgcgtg tagtgaatgg tgatcaaaaa gccgttatga cgatcacaaa agaaaaagcc 1175341 tataaagatt ttcctctctc ttttcatagc ggcgaaacgg cagatgtgag gaaacctgac 1175401 ggcaagctgt ttgccgaggc tgctgttccg gtgatttgga ccgatggaca agtcgtgtct 1175461 cttcagctgg ttgaaagact ggagaacaca gaagagagtc tgtttctgct gaaaatcatc 1175521 ttaatcgctg caagtgctgc tgtctgcatt gcttcttttt ttgcaggcag cttgctagcc 1175581 cgccgaatca tcaatccgat cagacgatta atgatcacaa tgaaagacat acagcgagac 1175641 aaagaattta aaacgatttc tttagaagga cagtccaacg atgaattgta tcaaatgggg 1175701 ctgacattta atgaaatggc aatgatgctg aaggagcact atgataaaca gcagcaattt 1175761 gttcaagatg cttcacacga attgaaaacc ccgctcacta ttatagaaag ctacagcagc 1175821 ctgatgaagc ggtggggtgc aaaaaagccg gaggtgcttg aggagtcgat agaagccatt 1175881 cactcagaag cggtgcatat gaaaaaactg accaatcagc ttttggcgct ggccaaaagc 1175941 catcaaggac tcgaggttga tctgaaaaca atcgatctga ttaaagcggc gcgcgcggtt 1176001 atgcaaacgc tccagtccgt ttatcagcgt gacatattgc ttgaaacaga taaagagagc 1176061 ctgcttgtaa aggcagatga agaacgcatc aagcagctgt tgaccatttt gcttgataat 1176121 gcaataaagt atagtgaaaa gcctattgag atgtcagccg gaacgaggaa tggacggcca 1176181 tttctatcag tgagggatga aggcatcgga atacctgagg agcatatccc gcatttgttc 1176241 gaacggttct accgggcaga tgaggcacga aacagaaaaa caggcggaac aggtttaggc 1176301 ctttccattg ccaagcaaat cgctgatgag catggcattg agctgtctgt caaaagcaag 1176361 ccgggacaag gaacagctgt caccatgcaa ttcagcgaac agaatggggg aggccgatga 1176421 ctaaaacaat aaaaacagta tcttttgctg cagcagccat tttagttgtc atcatctgta 1176481 cgtttctcat cattcggcaa acccatgaga acgtattgtc aaaggagact gtcgtaaaaa 1176541 aagtcgaagc ctcttatgaa ggcaaggtca cgaaagcaac acaatcaaag gataaaaaaa 1176601 catatgatat aacccttgaa aatccaaagg gaacttactt tgtaaaagca gacgcaatat 1176661 cggctgacat tctttcaatg aatagagtaa aagcagtgaa tccatctgcc atgacagaaa 1176721 aagaagccga gcatctcgcg cttgagcggg tgccgggaac ggtcaaaaaa caaacacggc 1176781 aaagtcaagt tgccacttat accatacaaa aagaagacgg gaaaacatac gaagtgaagg 1176841 tagacatgca ggcaaaaaca gtcttgtctg ccgatcaaat cagcagcaaa gatcaacaaa 1176901 aaacgccgat tacgaaaaaa gaagccaaaa caattgcaga gcgaaaaacg ggcggaacag 1176961 cggatgacgc agatctcgaa gaaagtgagg gcactctcat ctttgaagta gacgttgatc 1177021 ttcctgataa taaggaagcg acagtgaaaa tcaatgccta cacaggaaag gtagctaaca 1177081 ttgtgtatga agactgacgg tttctcatca aattctcatc ttgctctcgt tttcctttca 1177141 tgttgagtat gtaaactgta ctcatacaaa acaaaggagg gctcacaaat gctcaagaaa 1177201 aaatggatgg tcggtctttt agcagggtgc ctagcggccg gaggattcag ctacaacgcg 1177261 tttgccacag aaaacaatga aaacagacag gcttcttcta agacggatgc actcactgaa 1177321 caagaagcag aagcaattgc taaaacagtt gttgacggca cagtagaaga cattgacaga 1177381 gacctttaca acggcaaaga agtctatgaa gtggagattg aaaaagaagg tgaagactac 1177441 gacgtttatg tagatattca tacaaaacaa gcgcttaatg acccgttaaa ggagaaagca 1177501 gaacaagtcg ccataaccaa agaagaagct gaagaaattg ctttaaagca aacaggtgga 1177561 accgtaacag aaagtaagct tgacgaagat gacggtgctt acatctatga aatggaaatc 1177621 caaacgaagc aaggaactga gacagaattt gaaatttccg caaaagatgg acgcattatc 1177681 aaacaggaga tagatgacta atcaaaaccc ccgctgcagc gggggttttt catgataaga 1177741 aaccttcttt tggacaatct aagtagaaaa ggaggcgaaa cgcatggaaa agaaagagga 1177801 gcaatacatc aatcaggctg aatatgtccc tcatccgacg aaggaaggag agtatgcctt 1177861 atttcttcat gaaacgtatc atttgctttc tgaagatgac gagacacaaa caacagaata 1177921 agggcttagg cccttgtttt gttccgtaat tgtgatgtaa gcgcatttat tacttttttg 1177981 agttgacata gcttgttttt ttctgtaatc tcagtgtgtc aattcaatta ggaacttcgt 1178041 taggtgaggc tcctgtatgg agatacgctg ctgcccaaaa atgtccaaag acgccaatgg 1178101 gtcaacagaa atcatcgaca taaggtgatt tttaatgcag ctggatgctt gtcctatgcc 1178161 atacagtgct aaagctctac gattgaaggc gcccgcacgc tttttttgcc gtgcttcttt 1178221 caccttcaat cccgaaggct ttttttatgc ctttaaaacg aaaccaatca aaggaggtgc 1178281 ggagtatgga ttctccccat tcgagtcaat ctgaagaagt acccatatac tatgacagca 1178341 agacaattga ttacacgatg aggagacgaa ctgccgcacc ttctggcgag gccggcacgt 1178401 ctccgtagag gaggtacgag tcccgatggt tcaaaacatg acctatgacg aactcatttt 1178461 acgcatcatt attttactgc gagacgggaa aatcagggat tttagaagtg ttattgatga 1178521 gcttcagccc tatgacatgg catttatttt taaagaaatg ccggaaaaac atcgcgcccg 1178581 ctatttatct tatttaactg tagacgatat cactgatatg atcggggagc tggaacgcga 1178641 atttcagctt gtcgtcttaa ataaagtcgg aaaaacaaaa gcaacactgg cgatgaacaa 1178701 aatggacaac gatgacctcg ctcaattgct tgaagaaatg gacgaagaac tgaaggaaca 1178761 gcttttatcc agcatggaag cgtcagaatc aaaagctgta cagctcttga tgaattaccc 1178821 ggctgattca gcgggacgca tgatgacaaa ccggtatgtg tggatccctc agcattacac 1178881 ggtaaaagac gcggtcgtca aactgaaaag cttcgctgaa atagctgaat cgatcaacta 1178941 cttatatgtt attaatgaaa gcaaacagct ggttggggtt ctttcctacc gcgatttgat 1179001 tctgggtgaa cctgaagaaa aggtgcagga tttaatgttt acccgcgtca tatcagcaga 1179061 tgctcttcag gaccaggaag aagttgcccg cctgatagaa cgttacgatt ttttggcaat 1179121 accggttgta gaagaaaaca acgtgcttgt cggcattgtg acggttgatg atattatcga 1179181 cgttgttatt cgggaagctg atgaggatta cgaaaaattt gccgcttccg gtaaagacat 1179241 cacctttgac acaaaagctt acgtggcggc ataccggcgt ctgccatggc tgattttact 1179301 cttatttatc ggactgattt caggaagcat tatcagctat tttgaagacg cgctgaagca 1179361 ggttgtcgcg cttgcgtttt tcatgccgat ggtgtcaggg atgacaggaa atacgggaac 1179421 acaatctctt gcggttgtca tcagaggttt gtctaaagaa gaaatgaaca aaaaaacgat 1179481 tgtgcgcctg atcttccggg agttcagaac aagcattttt atcggagcgg tttgttctgt 1179541 gctgattgcg attgtttcta tcatatggca ggggaatgcg cttttgggat ttgttgtcgc 1179601 ctcttcactg ttcttaacct taatcatcgg cacgatgtca ggaacgatta tccctattat 1179661 tttgcacaaa ctgaaagtag acccggcgat tgcttctgga ccgctgatta caacgttaaa 1179721 cgatatttta tctttattaa tctactttgg cattgccact gcattcattc actcattata 1179781 aacgtaaaaa gtccgtctca actgcgagcc ggacttttat tatttaacgg tttttgtacc 1179841 gaaagtgagc attaagctgc ccctccagca tttttttccg cacttgcgga tcgtttttta 1179901 acatctgttc ttttttgcgc atatccttta aaatctctgc cgtctgtacg ccgtcttcac 1179961 gcttattggc gatatccatc agccgctcca catcggcaaa ggagtatttt cttgtccccc 1180021 ttgaagaacg ctgcgggtaa atgagctttc gttcctcata atacctgatc tgtcttacgg 1180081 acaatcctgt caattcactc acaattccga ttgaaatcac ttttttgtct ttataagaat 1180141 gatcttctgt ggtcattttt ccacccctgg atgtcttttg ataatagtat ataaaaaaca 1180201 aagagaaaaa acctgacgct tgtcatattt tctaacatca aatagaagat ttttgaaaaa 1180261 atacggaaga aaaattaaca agaataatgc gtaacaccca agcgcgtttt atcctttatg 1180321 taacgaatca aacgaggagg aaggataatc atggaggaag aaaaagcagt ctcactggca 1180381 aaagaaatta tagagttgga tatcaagcgt gatgaaatgc tggagacgtt tatgcagctt 1180441 gccggagaac aggcttttca attattaaga tcggttcaaa acggacaata ccgaaaatct 1180501 tcgtaaacat aaattcttta cattagattc ataccacgtt catttaaaaa gagtatcttt 1180561 tgtataggat acctcaaaat gaaggaggac gctatgagta atttattgaa atccgcttta 1180621 gaaaaagaac gacgccatta ttctgaaaaa ctctatcaga taggggttta taataaagag 1180681 gtcatgaaca aaatgacgat ttctgagctt cggaaagaat acgcttattt ctttcgaagc 1180741 attacaaatc ataaaaatta tccttataca agataatgta taaggatttt tttgctttta 1180801 gaaggaattt ctcgaattat agcgaatacg tatagtaagg gactgaactc ttattatatg 1180861 taagggtttt cattattttt ttataaaaat cctatatacg aggtagatat gatgagatta 1180921 tcgtttaacg aagaagaagt tgagcgtgcg atgaatttgt acagagtttt tgcaagggct 1180981 ttcaaaagtg tgtccgaaca tagtatccgt gatagcaaag agcacggttt taatcccact 1181041 gaatttgctg tactggaact cctgtacaca agaggcccgc aaaaattaca gcaaattggg 1181101 tcgagacttc tgcttgtaag cggaaacgtc acatatgtta ttgacaaact agaaagaaac 1181161 gggtttttag taagggagca ggacccgaaa gataaacgct ctgtttacgc acatttaact 1181221 gacaagggaa atgagtattt ggataaaatt tatccgattc atgcactgcg tattgcgaga 1181281 gcgttttcag gtctttcgcc tgatgaacag gaccagctga tcgtcctgct caagaaagca 1181341 ggcatacaca gccagcattt gctgtttcgt taactattct acactctcta tttcaggaga 1181401 gtgttttttt gtttccatat gattcttttt aaaacatctt taatcttcct atcagacatt 1181461 tcgccaaggt atccattgac gtgtttttta tactccttca tctgttcgtt cgattgaaaa 1181521 aatgccgcga tatactcttc tgctttctgc atgtcccagt ttctcatatc tgtgacgagt 1181581 ttcctttcat gtagaaggtt taaattcatt tcctcctgtc ccggcagtgc atgataaata 1181641 aataccggaa gccgtttctg taagcattca ctgatggtca cgcctccggg tttagtcatg 1181701 atgcctgtcg cctgttcgta caaacggttc atctctgctt tgctgtgaag gtaaggaatc 1181761 gcctcaatca aggggtggtg taaacttttg acataggagt agagcttttc gtttctgccg 1181821 cataatattt tgtataagat ctttccgcct ggcgacagtt cctgcaccca ttttaaaatc 1181881 ccaccgaccc ccatactgcc ccctgtgatg atgatggtat atggcgggtg gtgctgcaag 1181941 gtatctgctg attccatttc aaaattttgg tgaactggaa tgccggtcaa gtatatgttg 1182001 ttctgatcga taccctctga tattagctgc ttctttactt ccgtgctcgg aacaaaatgg 1182061 taatcaatgt tcttccgtcc ccataattga ttcacgaaaa aatcagtgta tacattcaca 1182121 accgtcagat tcggatattc aggctttagt cggttcagca gataagaagg cagcgcatgt 1182181 gtgcagaagg cgatatcagg ctgtttttct tggaggatgt gcctcatttg ctgtgtgaac 1182241 agccattcgt acatgaaata gcgtttgtca tgctgaaatt ctccgcaggc gaggagcctg 1182301 taaatgccgc tgtacgtttt cgggaaatat tgaatccatt ttaaataagc cacggaggac 1182361 aatttttcta accgcctata cgaatgtgaa aagatatcaa tcttttcagc tgccagccct 1182421 tgagactcta attcagcctg caatgcatca gccacatgat gatggccggt ggaaatgctt 1182481 aaaaaaggaa aaatgagaat gtttttcatg acagtcctcc taaaaaaata tggcaactat 1182541 attttgagga gaacgttcac aaaatataag ggtgtttttg atcataagga aggtgaaaag 1182601 atgaaaactt gtttcctttc catatggaga gtggttgatc cgatttattt ctttttttca 1182661 aggctaagct tgattgacaa cgatcaaaaa agcgtttttc gagtcaggct gacgaagtac 1182721 aaaggacatc atgtcgtgct tagcgacgga acgcatataa gaaaaaatga tgtgctcgtt 1182781 aaaatccacc tgcataacat aaagctgatc agggagctgc aaagcattga gagcgcagtc 1182841 agaaagggaa tcattattta tcagaaagta tatcaatcga tgccgcttct tcttgactat 1182901 atcaacaatc ataaaaaaag cgagaaaatc aaaggaatca ttgggattac aatgcttgac 1182961 aaaggtgtgg aaaggctcgg ctttgatgtg atcaccccgg tgaacccttt ttacagatgc 1183021 tttaaaaaag tgtctcatgt gccgatttta tatttgactt caaagcctgt gagcttgcgg 1183081 catttaccga attcatccta tttgtttatc tcaaaagaaa agctgcagaa aacctatcaa 1183141 aaaaaagact gatgcctcgg tcagcacagt cttttttgat taaatctgat gaaatgtcac 1183201 ttcagggcgg cttccgacac ggatatttac gccggtttgt cccaagccct cgctgatata 1183261 aaatggttta tcgtgatgat aatgaaggcc tttaatcatg ttcattcgca cgagctttcc 1183321 cattttcacc aaatgatacg gttttggcca gtgaatttgc ccgccgtgaa aatgccctga 1183381 cagcaggtaa tcataatgaa catctttcat atccagaata atatttgggt catgtgttaa 1183441 gacaagatga tagccatttt ccagactttg ataagagccg gtgatattac tccgattcgt 1183501 actgtaatca tcaatgccga taatattgac tggtcctgca gccgtctcga ttcgaacatg 1183561 ttcattttgc agcgtgatac agccgttttc ctctaaaact cgcttcaatc tctgaaagtc 1183621 ctcttctttc aatacataat cgtggttacc gaacaccgcg tacattccat atgcaggctt 1183681 tagcttttgc aaggcgttca agtaacctgc cagtttcgga atattacgtt tccgatcaag 1183741 aaaatccccg gtaagagcaa tgatgtccac aggctgatct tttgttaaat gatacagctc 1183801 ctcaggtgag actgaaatgt tttccaagtg aagatcagat aaatgaagga tatttaattt 1183861 ttttctggct ggaaggccgt ctttttggtc gattgaaatg gtgttgactt tcacatcttt 1183921 tgtattgcgg ttcgctttat atagaaatgg cacaaatacg agtatggcca atgaaagtaa 1183981 gattgtaaac aaaatatatc ccctcccttc tatcagtata gtaagtgatc aagccctatg 1184041 gatagcggga attaatgggt agagacaggt tgaaaaacgg attgtcatat gatgaatgat 1184101 ttggaaggga aaagggataa taaattttga cacatgaggc agaacatgcc gacggagtca 1184161 gaataacaaa tggatgtgta agcaatgtta cgattgatga gacaacaaaa aaaagaaaca 1184221 tattatctct ggatcgcatt atttcttctt ttattgtatg tatccccgct ttttatttta 1184281 aaggaagatg cccatatccg ggtccacgat aatttagatt ccaacatcgc ttggtacaag 1184341 gttctggccg atagcggaga aatcgtcggc aaggttgacg ctgccattcc gcaaatcatt 1184401 aacgggctgc cccgggatgc ctttggcacc gagtggagcg gaattgtttg gctccatgct 1184461 ttcttttctt ccatgaccgc ctatgcaata agccagacgg ttacaagagt tgtcgctttt 1184521 tttggaatgt atgtgctgct gaagaaacat ataatcccgg aaccaaaagc ggctttcatc 1184581 cgaattggcg tatcgcttgc atttgcctta acaccgttct ggccttcggg aatgctgagt 1184641 acgcttgggt accctttggc actgtgggct tttttaaata tccgaaaagg ggatatctca 1184701 tggagagagt ggctgacgct gggcttgctc cctctatact caagctttgt tctaggcttc 1184761 ttctttttcc tggcagggat ggcgtgtttt tggctgtatg atgccattac aaaaagaaga 1184821 tggaatttga tgttcttagg cagtattgca tttatgacga gtatctatct tttcgttgaa 1184881 tatcggcttg tctattcgat gctgtttgag cacgcaccga tgcatcgtat cgaatttatc 1184941 tcatctaggc atgacgtttg gcattctctt cgactatcca taaaaaactt tgtctatggc 1185001 cataatcatg tgatgaccgt tcataccgtt gtcatccttc cgatcctgat ggtcgtattt 1185061 gctgctctgc tgttcaaacg aaatcggaca aagccagaaa atgtttatct gtttttatgt 1185121 gtgcttaatt acgggttgtc attatggtat gcgttttggt tcaacaaaat ttgggctgtt 1185181 ccaaagcaga aatttgcttt tttagcagaa tttaattttg cccgttttca ttttcttcgg 1185241 ccgcttgtta tatacgtgag ctttgcgctt gctttatatc tcatttggcg gatggggaaa 1185301 ggatggaaat ggcttgtgta cgccgcagtc gctgcacagc tgatggtgtt ggcgcctttt 1185361 aatgaagaat atacgtatgg tgttcattac aacgcgccga cattcaggga gttttatgca 1185421 tcagagcaat tcaaagagat taaggaatat atcggacgtc cgcaagattc gtatagggtg 1185481 gcgagcatcg gactgcatcc gtctatcgcc caatataacg ggttttatac gttagatacg 1185541 tataacaatc tgtatccgct ctcatataaa tatgaattta gaaaaatcat cgaaaaagag 1185601 ctggaaaaaa attctcggct gaaacaatac tttgatgaat ggggcagccg ctgctacctt 1185661 tttgtcgatg aactcggtaa acgatatgat ttcaaaaaga actcgaagaa aacgatcaac 1185721 aaccttcaat taaatacaga tgtatttaaa aaaatgggtg gacggtacat tttttcttca 1185781 gttccgatca tgaatgctga acaaaaccat ctcgcgctcg taaagacgtt tgaccataaa 1185841 gattccgcct ggcgcattta tttatatgaa acaagataag gaggatatcg attgaaacag 1185901 tcacagccag tattaaccat cgtcgtcccg tgtttcaatg aagaggaagt gtttcaagaa 1185961 acaagccatc agctgacaga ggttgtagat gatttaattg aagaaaaatt aattgctgaa 1186021 gacagtaaaa ttctgtttgt cgatgatggc agcaaagacc gcacttgggc tttgattgct 1186081 atggagagca taagaaacaa gaaggttacc ggcttaaaat tagcctgcaa tgtcggccac 1186141 caaaaagcgc ttttagccgg attgcataaa gcgaagaata ggtcagactg cgtcatttcg 1186201 atcgatgctg atcttcagga cgacatctct gtgatccggg attttatgct gaaatatcat 1186261 gagggctgcg agatcgttta cggtgtacgc cggagcagaa aaaccgatac ctttttcaag 1186321 cgcacgaccg cgttagggtt ttatcgtctc atgaataaac ttgggattaa attaatttat 1186381 aatcatgctg attttcgttt aatgaataaa aggtcccttg aagagcttga gcgttatccg 1186441 gaagcgaatc tgtttttaag aggtattgtc cccatgatcg gctttaaatc ggccgaagtt 1186501 ttgtatgacc gcaaggaacg ctttgccggc aaaacgaaat atccgctgaa aaagatgcta 1186561 tccttcgctt ttaacgggat tacttcattc agtgtcgcac caattcgatt ctttacgctt 1186621 ttagggtttg ttttgttttt cctcagcgct gtggcaggga ttggcgcgtt tattcaaaag 1186681 ctgctcggcc atacgaatgc aggctgggcg tctcttatca tatccatttg gtttttgggc 1186741 gggctgcaat tgatgggaat tggaatcatc ggagagtata ttggaacgat tttttctgaa 1186801 gtgaaaagac ggccgaaata cgcgattgat attgatttgt ataatgaaca gctgagcccg 1186861 cttcagcgcc aggaaaaaga gcggttagaa aaaaagtaca gttaaacacg gaaagagctg 1186921 acttcattag tcagctcttt ttcttcaact gatgcaatat agcgctaagc ggttcgtctt 1186981 gcgggttgcg gtaaaaatca aaaaatgggc agccctgctt cttaattcga tcgatgaccg 1187041 tatcaattgt aaacagagcg ggtgttaaag atgattgcac ctcatgccag tagagcgggg 1187101 ctgcaacagt cccaagctca tttcctctcg ttgaataggg acagataatc gtttttcctt 1187161 ctgcatgctg caaataatca agatacaatt tgcagtgtct gtttttaatc aagcgttcag 1187221 tggtaaagag ctcgggaaat gcattggtgc agtactctgc gatcagctgc gtaaattggc 1187281 gtgtttcttc atacgtaaat gcctcgggag acaagggaat ataaagctgg atgcctttgt 1187341 tgccggacag cttcgggtac gatgtgatgc caaaggaatc caacagccgc ttcagttcat 1187401 ttgcggcctg cacggccata agaaagtcat ctcgcgaagg cgggtctaaa tcaatgacaa 1187461 tctcagccgg acgcctgctt ttaatggttt gaaaaggaac gtgaaactcc aaagcaagct 1187521 ggttgcaaag ccatagcaat gtagacatat cctcacagac aatatgttca tggcttccat 1187581 catagaaaga ctgaacaaaa tccggcgcat agtccggctt gtttttttgg aaaaatgatt 1187641 cgctcctaga tccatgcgga tagcggatga cggtgacagc ccggtttttc agaaatggga 1187701 gcaggtagtc actgacttca atcatatact gaataaaatc ttcttttgtt tttttattct 1187761 tttcaaatat gattttatcc aggcttgtga actggagctt tgggtgaacc ggtttggagt 1187821 gtcgtatgac ttgcgcatac gtgcattcgg tccagtccat ttggaattcg aaaccgataa 1187881 acgatacctc tcttaatgtg ccttggagaa ttgttaagta ttgaacagct gcacaaatcg 1187941 aaggttcaag cgtaaattcg cctgagggtg tttgatgtcc gtgctgttcc ataatctcgc 1188001 gtatagcgct tttttcctca tcacgcattc cgtgcgagac agaggcaatc ggtgtcatta 1188061 ttccgttttt taacaccgat accgtcagaa acccgttgtt agggttgaac cctgttatgc 1188121 aaacataagc ttgtttaaag tttttatatt tgagccaatc ggacgaccgc ttcttttcaa 1188181 gccatttgct gtttgttttc ttcgctacaa ttccttctcc gtcatatttt attaccatct 1188241 cccagagttg atcaaaatga tcataacagg gaatggattg aatggtttct tttgcgtaag 1188301 gatctggaga tgcaggaagc tttgctgcgg atatgagttc acgcagcgat tttttgcggt 1188361 ccaaatacga aagaagcgtt acatcttctc cgcttcgctc taacaaatca aaggcgagaa 1188421 agcagcacgg ccgcgcgttt gccgattcct gaatcttgtc tggccttttc aaacgccccc 1188481 gcacttgaag gtgttcaaaa tctgcacgac agggattcac caaacatacg atttcaccgt 1188541 caagtgtcag cggaagctct ttttctaggt gctgaaaggc agttttggcg aattgtgtga 1188601 tttcagggaa ggtgctgctg agctccacac catttctgct ggttaaggtc acacctgaag 1188661 aatggatgcg gagaatacag cggtacccat catattttac ttcgtaacgc cattctgctc 1188721 cgattggcgg tgacgaagtt aagaccggct gcatggtaaa cgccatgcgc tatgatgtgc 1188781 cggaggcttt ttttctagtt gttttttgtt ttttatctcc ggctcctttc ggttcagcgg 1188841 cttgtgcagg tgcggcagcc ggtgtctccc ggttcggcct tctggttctg tcgatgctgg 1188901 cttgcagagc gcttaccagg tcaatgacat cttcacgagg tggcgcttta tcaggagtga 1188961 cagccgtttc tttattttct agcttgtcgt tgactctttg cagcagcgcc tgtcggtacg 1189021 tgtcttcata tttctcaggc tcaaacttag cagtcagttc atctattaat gtgatagcag 1189081 tttgcagttc cttatcgttt acattcgatt gatcaggtac acctgggact tgagcggcgc 1189141 ttctgacctc atcgggataa tggatagact ccatgacgat acaattttca taaacgcgga 1189201 gaatcgccag ctgctgcttt gacctgattg tcatattggc gataccgatc tttccggttg 1189261 agcgcagcgc ctcacgcagc agggtatagg ccttcgtccc attatccccg gggccgacaa 1189321 agtaggagcg gttaaaataa atcggatcaa tttcctgaag ctgaacaaag tcaacaatct 1189381 caactgcttt ctcctcatgc tcctgtttta agctttttaa atcttcgtct gtcagcacta 1189441 catattttcc ttttacatat tcatatccct tcacaatttc atcaggacta agagtttttt 1189501 cgcaatttgt gcaaactttc tcgtatttga ttggtgcgtg atcctcttta tggaggctgc 1189561 gcagtttaat atctttatct tctgtggccg catatagctt gatggggatg tttactaatc 1189621 cgaagctgat cgatcccttc cacattgtat gcatatcgat aaaccccttt ttttctttag 1189681 tgtgaagaga aggagtacga ttcatgtgta gtaacttatg ggtgaaaaaa agccggcgct 1189741 gttattgcga cggctgttca ataatgaatt gttcgaattg ttccggaggt attggcctgc 1189801 tgaaaaagaa gccctgcaaa tggtcgcagc ctttttcaaa aagaagctgc ttttgagctg 1189861 cattttccac accttcggca atcacctgca aagacagctg atgccccatg gcaataatag 1189921 ctccggtaat ttgctctgat ttaggatggg tctgaatatc gtcaataaat gatttgtcaa 1189981 tcttcagcct gtgaatcggg aagtccttca aatagctaag agagctgtga ccagtaccga 1190041 aatcgtcaat actgattctg attcctaatt ctgttaggga tgacaaaacc tttttggagt 1190101 gattgagatt gtccattgtc atgctttccg tcacctccac ttcaagaagc tgcggaggaa 1190161 gctggtactt attaagcgta tccttgatga ggggaatcag atctttagat tgaaactgtc 1190221 tggcggaaat attaatggcg acagaaagat catagccttt gtcatgccaa atccttgcct 1190281 gcttgcatgc ttcatctata atccactttc cgatatcaat aataagtccc gtttcttctg 1190341 caacaccgat gaattctccg ggcggacgca gttgcccgtc tggtgtcaca aggcgtatca 1190401 gtgcttctgc tcctgtcatt ttttgttttt tcacactgaa ttgcggctga taatgcaaga 1190461 caaatctatc gttttcgatt gcttctctga gtaccatctc ttggttaagc ttaacggttt 1190521 ctttgttgcc gattgaaaaa gaatagtatc tgtatttgct tttgtttcgt tctttagccg 1190581 catacatcgc catatcagcc tttttcatca attcaaggcc atccgtcccg tcttttggag 1190641 atatcgcaat cccgatactg acagatgtga caagggtgtg atcttgaatt ttgaaaggtt 1190701 ttttgaattt ttggataatt tttcttgcta aaacatctgc ttcgcctgtt cctgtattgg 1190761 cgtctgttaa tataataata aattcatcac cgccaagacg ggcgataaat ccgttatcag 1190821 ggactacaga tgacaggcgt ttagctgcaa actgaagcaa ttgatcaccg acattatgcc 1190881 ctaatgcatc gttaatcact ttaaaccggt ttaagtcaag aaagaataca acagtgttat 1190941 aatgcaagga atgctcgcga ttcagcacct ttgttagatg agagatggca tgccttctgt 1191001 taggtaagtc tgtaagcgaa tcataatgag ccattctatg gatttctttt tctgctttgt 1191061 actgcttcgt catgtcttta caaatgacat aaatgctgtc tagttcctga ttgacctcaa 1191121 caggtataag cgtaatattt aagtgaaact ggcctttttc agtgataaga tcgctatcgc 1191181 tgttcatcgc ttgtttatct tttttaactt gctcaaaaag gcgcttaacc ttcagtgatg 1191241 tgtaattcct ccagtcatgc atgctgaagc caaatttgct gatcatttcc tcaccagcgt 1191301 gattggaaga tattatgtct ccttctaatg ataaaataaa aattgcatca atattgtgga 1191361 cgattaaaga ctgaaatcgc tgttcgttat cctttatgcg ttcgctctgt ttaataaact 1191421 ttcgatctgc atgggaactg aataacaata acgtttggat acaaaaaata attaaagtaa 1191481 caaaaattga ccaatgaaac gtttgcacct ccatatggct tccgggcgga gccatgtcct 1191541 tatggaaagt tgccgcaagc atccctgtgt agtgcatgcc cgaaatccca atgcccatta 1191601 caattgaact gacgccttta tagaatataa gatgctcaga atgttttttt acggccaagt 1191661 caaagaatat ttttaacgag acgaaagagg ctgcaatcgc aatgataatt gaaactgtaa 1191721 ataaaatagg ttcgtaaata atcattaccc gggaaatggc agacattccg atatagtgca 1191781 tagaagcaat agatgcgcca agcacaactg atccggtaag cagtctgtaa tatgtaagaa 1191841 tgtgccggct gacaaaatat aatgacacaa atgatcccga aacagatgcg ccaatggctg 1191901 ccattaaagg catgaattca tattccatcg gcatttccat atggacggcc atcatcccta 1191961 caaaatgcat tgaccaaata ccgaatccca taataagtga gccgccgatc agccaaattt 1192021 tactttttaa gcctgtattg atggtgactt tccttgaaag ttcaagggaa atatacgagg 1192081 cggtacaggc aattagaata gataaacata tgagagtcgt attatatgta acgtgtattt 1192141 ccaaatggag attccccccg tatcgtgtgt tccagtcttg ttgactctct ttattatcgg 1192201 ctgcttaacc gcagagtttc agccttcaaa acgatagaaa tacgagggag atctattttt 1192261 agttcaactg accgtgaaaa atgtgttaaa atcatcttga tgttttccga aaagagaaaa 1192321 atgtatgata cataaacatg aaacaaggga gttggtggct atcgaagagc tggttatgtc 1192381 atggattgaa gcatttaaaa gcttatctta ttttggaata tttctagcgc tcagcattga 1192441 gtttattccg gccgaagtcg tcttgccgct tgcgggctat tgggtatcta aaggcgatat 1192501 gacacttgct ggcgttgttt tggcaggatc gcttggagga gtggccggtc cgcttacgct 1192561 gtattggata ggccggtacg gaggaaggcc gtttcttgaa cgttttggga agtatctctt 1192621 tattaaacct gaagcgcttg ataagtcaga taattttttc aaaaaacatg ggggctttgt 1192681 cgccttcagc ggccgtttct tgcctggtat caggacattg atttccatac cgtgcggaat 1192741 tgcaaaaatg aatgtttggg tgttttcgct ttatacattc attgctatgc ttccgattac 1192801 atttgtatat gtttatctcg gtgtgaagct cggtgaaaat tggaaggcag tcggctctat 1192861 tcttgatcaa tatatgcttc cgatcgggat agcgattttg gcgctgttcc tgctctactt 1192921 actgatgaaa aagaggaaga aacgcacgca ctccgaacaa ttatctgtat ttttgaaaaa 1192981 taaacgttga caaatcactg cgctgcgcat attattgacg tataaaatca tatttcttga 1193041 aatcccaaag gggagtagcg tccggaatgt attccggaaa caaagtcgtc atttcatgga 1193101 ttgtatccat cggctttgtt ggcatgcctg aattcatgtc tagcaagacc tttgccttat 1193161 gtcggcaaag gtcttttttg catggtccgg ccggcataag atcggatgaa gagaaagaaa 1193221 acaacttttt tgggagggta tcatttatgg atgcagcatt attattagag tatggttggg 1193281 ttcttctcgt cttgatcggg ctggaaggga ttttagccgc cgataacgcg ctggttatgg 1193341 cggtaatggt aaaacatttg ccggaggaaa aaagaaaaaa agcgttattt tatggattgg 1193401 caggggcttt tgttctgcga tttggctctt tatttgcaat ttctttcttg gtcaacgtat 1193461 ggcaggttca agcgattggc gcgatctatt tgctgtatat ctcagcaagc cacttattga 1193521 aaagatatgt atttaagaaa gaagacacac ataaagagac gaagcaaagc ggtttttggc 1193581 cgactgtttt aaaagttgaa ctggcagata tcgcgtttgc tgttgattcc atcttagcag 1193641 cagtagcgct ggcggttaca cttcctggga catcactccc gaagatcggc ggacttgacg 1193701 gaggacaatt tctcgtcatt ttggccggcg gtatcatcgg actggtgatc atgcggtttg 1193761 cggcttccat gtttgtgaag ttattaaagg aacgtccaag cctagaaaca gcagcctttg 1193821 tgattgtcgg ctgggtcgga gtgaagcttg ctttatatac gcttgcccat cgcgacatag 1193881 cggttgtttc tgagcacttt atccattctg gaacatggaa gctgatattc tggggtgtct 1193941 tagcagcaat cgcggtttgc ggctggttta tgtcaggtgg gaaaaaacag ccggagggtg 1194001 cacaaaacga acaaaaaaac agcacccgtg aacgggcgta atctgaaaga ctctgcttaa 1194061 aagcagagtc tttttgtgtt tgaagcgttt tcataagcga aataaaataa catttttata 1194121 acatctttgt tacaaaaaac acgcataaaa cccccttaat tctttagaaa ggcacgaaat 1194181 catgtataga acgtcagaat ggtttgtcat aattgagaca ttggaaatca atatttcttt 1194241 ttctcctttg cgaatcccta tcaaattagc tatcattaat gagtagttat agggaggaac 1194301 tgaggtgaaa ccagtgctta gccttttgtt taaattggga aaaaagaagc aaacacttga 1194361 aaaagctgtt gagagtatac aaaaaggcaa taaagatctg caaaatgaat taatacagca 1194421 atataagcca tttatcgcaa agacggtttc atccgtttgt aaacgatata tagatgaaaa 1194481 agacgatgag ttcagtattg gactgatcgc gtttaatgaa gctatagaaa aatattcacc 1194541 tgaaaaagga aattctctgc tcgcatttgc tgagcttatt ataaaaagaa aagtcattga 1194601 ttacattaga aaagaagcca gaagcgcaca aaatataaat atcgatttac aggaaggaga 1194661 cgatcaggag tcatcacaaa gcctgattga agccgagctt tccattgatg aataccgccg 1194721 tcagattgaa caggagcaga ggcgggagga aatcctctat tttcaaaagc agctcaagga 1194781 ttatggttta tcgtttaaag aactgcttga aaattctcca aaacacacgg atgcaaggca 1194841 aaacgccata aaggtggcaa tgacgcttgt tgaacatgaa gaattggccg ctatcctgta 1194901 tacaaagaag cagcttccgg tcaaacagct tgaacagctt gtctctgtaa gccgaaaaac 1194961 gattgagaga aacagaaaat atattattgc gatgtgtatt atcattacgg gtgattatat 1195021 ttatttaaaa gattatctta aaggggtgct gcactcatga gaagagggat tatagtagag 1195081 aaaaataaaa aattcgtcac gttgctgacc cctgacggac aatttttaaa agccaaaaat 1195141 gatcgacaca gctatgaaat cggagaagaa atcatgcttc cgagtgaaac acgcatgggc 1195201 agaagggcca gcttttttga tttttttaaa ctgcgccctt tcaaaatggg gatttttacg 1195261 atgactgcta ttatgctctt tatttttata gttctccccg ttttttctaa taataaggcc 1195321 tatgcgtata tgacaatcga tatcaatcca agcgtcgaaa tggcgttaaa cagcgattat 1195381 gaagtgattg aactgacgcc tctaaacgat gagggacaga aagtcgtgaa tgatatagat 1195441 gattgggaga agactgattt taaaaaggtg attgacgata ttataaccga ctgcagtgaa 1195501 cacgggtatg taaaaaaatc gaaagaaata ttgatttcca ctgtttatga aaacacagaa 1195561 gacaatacat ataaaaaggc tgtgaaaaaa cagctgaatg atgtgactga aaaatataaa 1195621 acgacatacc gcatggaatc tctcgagtca gatatgcaaa cgagggaaaa agcgaagaaa 1195681 gaaggcgtct caacaggcag ctacatcaaa tcaaatgaaa agaatgacaa taaagatata 1195741 aaagatgact ccagcaaacc atccggggaa gaggatcaaa agagtgatga aaatgaggat 1195801 gaaaacaccg atcaaactga cacccaggac agcaagcaag gagataatga acagctgaat 1195861 gatgcggatt ccggagacca gaaagaagag aaagcggatg accagattga tgatagtgac 1195921 aaagataaaa aaataaagga atcagatgaa aacacaaata ccgaaaaaga tggggaccat 1195981 gagcaaaccc caatacaaga tcctcaagat aaaggaaatg aaaataacgg cgctgacaag 1196041 ggccaaagcc aatatcacag ggactggaac aatggtgaac aaggcaagaa ccgttcttcg 1196101 tccagaaggg ataacgcttc agaccgacgt aatccaaacg gctacagcag tgataatcat 1196161 tcagctaaaa atgaagattc gccgagtgcc cccggcgaat aaagacctga atttatttag 1196221 ttgtgccatt taattgtgat tgtgcttgct gtaccagccg ctttgtcatt tctccgccta 1196281 cagagccgtt agcgcgtgcg actgtatcag aaccaaggtt cacaccgaat tcttgagcca 1196341 cttcgagttt aaattggtct agtgcctgct ccacccctgg aacaacgagt ttatttctgc 1196401 tcgccatctt tttcatctcc tttttcgata aagaaattct taacgcgtat ttagtttgaa 1196461 atatacgggg tttatttatg ctggcaattg ttgtggagaa aaataaaacc ccggcctctg 1196521 agccggggtg gcgcagacta tagaatgtct gctgtcattt tatgtgcggt tgcctgaata 1196581 tggaatgtca aaatggagag gactgtaatg gcgataatct gtctgatttt aagccattgg 1196641 ctgtcattca gttcttcaaa acggtgacgg agacgctctg tctcctgttc ggcgatctcc 1196701 tgcagatttg attctttcat agaaggagta tcttggtgat ggatggcatc aagcacatat 1196761 gcgcagcttt cataataagc aatcgggctg atgacatcat cagatctgtc tgagattgtg 1196821 ttaaaggcca cttttaaaat agcccgtatg tgttcaaagt cataaatgga ttttaaatca 1196881 cgtacaatta aaagaataac tgcctgttca attgagtatt ttttgcccag ctcagggtgt 1196941 ccgatcagat ctttgatatc acgctttacc cagttttgaa tcgcggttga ctttaacgaa 1197001 gtcagctcgc ataagttgcc aagctctacg atttcatttg tagacagacc gtattctttt 1197061 ttctgttttt ttcgttcgta tcttgtaaga aattcaggaa tttctagatg attggctgct 1197121 ttttctgctg acatgttcgc tgattggacg agaatgtcga gcgggctatg ttctccttgt 1197181 ccttttaggg aatagagcag ccgcaccata tcggttcgag agagtttaaa aatgttcatt 1197241 gttcacctct ttaaacaatt tgacgcggat ataggtctat gtataagttc aaaattcaag 1197301 cgtcagcaaa ttacattaac atcatacgtc gaattccttg cattttcaaa tggatgtttt 1197361 ataatttaaa tatacgggtt cttttgaact taaaataacg gaggttgtta tggcgaaaag 1197421 aatttttctg tttattctaa cgaatatttt ggtgcttaca acaatcggga tcgttttgtc 1197481 tgttttaagc tctgttacag gagtcgggac gtactttaca gctgatggcg gtatcgatcc 1197541 aatggcgctt cttgtgttca gtttagtcgt tggatttgtc ggttccttta cgtctcttgc 1197601 gatatccaga tggatggcaa agacgatgat gggcgtcaga gtgctgaatc cgaaaaaaca 1197661 ctcgctcagc tatgaggaac agcaattggt tgatcgtgtt cacagattaa gccgctctgc 1197721 cggtttaacg aaaatgccgg aagtcgggat ttaccgttca cctgaagtaa acgcgtttgc 1197781 gactggaccg tcaaaacgcc gttcacttgt cgcagtatcg tcagggctgc tggagcagat 1197841 ggatgacgca gcagttgaag gtgtgcttgc ccacgaggtc gcgcatatca caaatggtga 1197901 tatggtaaca atgacgcttt tacaaggtat cgttaatacc tttgtcgtct ttttatcgcg 1197961 tatcgccgct tggatagcaa gccgttttgt caaagaagat ctagcgccga tcgttcattt 1198021 tattgcaatg attatttttc agattgtctt ttcgatactt ggcagcctgg ttgtgtttgc 1198081 gtattcacgc catcgtgaat tccatgctga caggggagga gcggatcttg ccggcaagga 1198141 caagatgatt catgcgctgc ggacgcttaa aagctattct tcccggattt tggaagacga 1198201 tcagacagct gtccaaacgt taaagattaa tggcaagaag cgctcttcac ttttctctac 1198261 tcatcctgat ttagatgagc gaatcagacg gctggaagct aaataataca aacacattgt 1198321 tcctctgaga gaattctcag aggtttttta ttttatccat tgactaaaat cataaaaaaa 1198381 taagcaagtt aagaaaatgt ttcgtaaaag cctttaaaaa tggacctaat atctttagaa 1198441 taattaccgt acttaaaaag agaggcagaa ggattttaca tgagattaaa gtttggaaaa 1198501 ttgatacagg ccttgtcacc ggcccagctg atcgcattat attattttct tgcagttact 1198561 gtggccgtta tattgctgag tttgccggcg gcccataaac cgggggcgga ttggacgttt 1198621 attgatgcgc tttttacagc tgtcagttca gtcagtgtaa cggggctgac agttgttgat 1198681 acagctgata cattcagcac aatagggatt tttatattag catttgttct gcaatttggc 1198741 ggaatcggaa ttatgacgct cggaacgttc atttggctga tcatgggaaa acgaatcggg 1198801 ctgaaagaac ggaagctgat tatggttgat caaaaccaat cccagttttc aggaattgtc 1198861 aatctgatga agcaggtact gtttctgatc ttgtggattg aattttttgg cgggctgata 1198921 ctcggcacat atttcttaac ctactatgac tcctatcagg aagcctattt acacggattt 1198981 tttgccagta tcagtgcaac gacaaacggc ggatttgata ttaccggtaa ttcgatgatt 1199041 ccatttcgcc acgattactt tgtgcagttt attacaatgc ttttaattat atttggagcg 1199101 attggatttc ccgtgcttgt tgaagtaaag gatttcctgt tttcaaagca tcggcgttat 1199161 ccatttacgc tttttacaaa gatcacgacg attacgttcg gctcacttgt cttgtttgga 1199221 gccattggca tctttgccct ggaagcaaac catgcgttcg caggaaaatc atggcatgat 1199281 attttgtttt tgtccctgtt tcaatcaacg gcaacccgaa gcggggggct ggcaacaatc 1199341 gatatcagcc aattatcaga ttccacactc ttttttattt gtgcgctgat gtttattgga 1199401 gcgtcgccaa gctcagtcgg gggaggcata aggacaacga cttttgcttt gaaccttctt 1199461 gcgctgtttc attttgcccg cggcaataag gccgtaaagg tattcaaacg ggagcttcac 1199521 cctgctgact tgatgaagtc gcttgttgtc acgatgatgg cgatcctgct cgtttttggc 1199581 gcgacactca ttctgaccat tacagaaaaa cattccctgc tggagctttt gtttgaagtg 1199641 tgctcggcat tcggtacaac cggcctatcg cttggaatta cggcagattt gagcagtgtt 1199701 ggaaaatgcg tcattatgat tgtcatgttt atcgggcgaa tcggcatctt gaccttcctg 1199761 tatctgatcg gaagaaagga aattgaagcg aattatcact atccgaagga aagagtgatt 1199821 atcggatagg caaaacaccg catattttgc ggtgtttttt gattaccaaa aaaaagatgt 1199881 gtgcctcctg ttcagttgga gaacctaact ccgacaggtg caatttacgc tcctgcatct 1199941 taaaatgtct gaaaattggc gaggaggatt cgtatgaagc gtaaagctga agtgaatgaa 1200001 gccattaaaa ataacaatac acctaccgag agcatggacc ccaattcata taagacacaa 1200061 tatcatgacg accccaattt tagaggggca aaccgcaatt ccaaacaggg ccagcaggga 1200121 ggcatgtaat tgtgaagaaa aaccgtcata gcagagacat gcaaaatcat aaaaagccta 1200181 tgaataaaaa ggtgctggag gaagaattct caagtgaact cggggattac aatgccggaa 1200241 agatcatcga aacgctggaa gtcaccaagc ctgaaaagaa aaaagaaaaa aacaaaaaac 1200301 aacaataaaa aagacctctt aggcggcgtc ccgcttaaga ggtgcttttt ctattttaaa 1200361 taagcatttt tgcccgttcc tctgacaaat tgcaataagc ttgtcatcct cagctcaatg 1200421 aatggctgag cgactgtctt aacaaagttg ctggagagga ctgatgtcag ggctgctgtt 1200481 aaaagcaaga ggatcactaa gctttgatag tcagtaagcc aatcctcaag cccgacctgc 1200541 cgtaatgtct taataataaa cccgtgaagc agatacacgt aaaatgtccg ggttccccat 1200601 ttggtaaaga aataccgttt ttgcggaacg agcgctaaaa agctgaaggt tgccccaaag 1200661 gcgagtacat accagccgat tcgggatagt ccgcttacca gggtaacgtc tccaaatgaa 1200721 gaatacggtt ttgaaccaaa cagaaaagaa tagtcaaaat cgatgcccca gcagatgacg 1200781 aatactgcgg caagcactcc gagcgcaatt tgtttgccgc gttttgatct caataaatca 1200841 aaatgatgtt tatttaaata aaaaccgaca aggaacatcg gtaagaatac gaatgtccgt 1200901 gacaagctca gcgtgctgct gacaaagtcc agataaccga tcagcacggc gattccgcag 1200961 ctgacaaaca gcgcccactg ctttgaaagc tttgaaaaag gatataggag caggttccaa 1201021 aagaataagc ttacaagaaa ccataacgac cattgcggat caatcgggtt cacatttgcc 1201081 atgctttcat cttgcataat gtaataaaag acggaataaa taatttggaa aatcaaatac 1201141 ggaataatca gcttgaccgc cagctttttt acatatcccg cccgtttaaa gcctttcgcg 1201201 aaataaccgg atacaagaat aaatgcaggc atatggaatg tgtaaatgaa cttgtagagg 1201261 tagagcataa aatgattatc attaataaag gaacgaagga tatgaccgaa tacaacaagg 1201321 aatatcaata aaaattttgc gttatcgaaa taactgtccc gcgatttact catagcatca 1201381 ccttctcttt catcagtcac taagagatta ttccctgctg gtacatattt taaaataaaa 1201441 gatgaaaaag gaatctaaaa aaatgctgat tgttaggtcg atgtaaagtg acggtaagga 1201501 tcgtagaaaa tgtcttcgta atgtaatgac gctgaaattt tctgaaattt atagggcaaa 1201561 tgaaggaagt tcccgcattt tgtagaaata ttgagggata ggttttgaag aaggagtgta 1201621 catgcatgga aactcttggt gtccagacaa actcggagct gcgagaggaa ctgaatcgcc 1201681 tcaaagaaga aaacgcgcga ctgaaaaagg aattgaatca gcatcaagtg attgtcaaca 1201741 atacgctcga tgctattttt atttgtgata acgaaatgcg gattgttcag gcaaatgaag 1201801 caacagaaag gatgcttcaa gttgactcgg aagatttgaa aaagcgttct gttttggatt 1201861 ttttgttttc aatcccaaag gatgaactga atctttccgt aaagaagttt tttaaaaaag 1201921 gctttctgtg gaaggaggtt ccgatcaggc ttgattgcgg ggcaacaaaa tacatagagt 1201981 ttctggccaa aagaggtatt ggtgaggatt tcttttttgt tgtcatgagg gacatatctt 1202041 ctaagaagat tctggagcgg gaattctcta tgaatgaaca gctttttaag gacttgtttg 1202101 acagagcagt tgacggaatc gtcctgtttg ataaagatgg cggttttatt gatgcaaatt 1202161 tgtccttttg taaaagcttt gaaatcaatc ataatgagct gtctcattta tctttgtatg 1202221 agttcataga cagcggctca cgaaaagatt tcgacaatat ctggaaggcg ctcaaccgca 1202281 agggaaaagc gaagggggag ctgcctgtca agcttcgttc aggagttcaa aaactatttg 1202341 aattcacgat tacatcaaac atcatcagcg gtttttatat gtccattatg agggatatca 1202401 cagagaagcg gtctatggag ctgcagctct ttaaaagtga ggagcgcttc agagaaatct 1202461 ttgaaaatgc aatggacgcc atcatcatct ggtcgaatga cggaagaatc gtaaaagcga 1202521 atcaatcagc ctgtaaaatt tttgagctgc cgatgaattt gctgttgaaa agaaagctgt 1202581 gtgattttct cgttgactcg cagcagaaat acagcataac gaagaggaaa tacgcaaaat 1202641 acggagagat cagagaagag ctgctgtttc aaatggggaa cggccaattc aaagagcttg 1202701 aatttacttc aaaacggaca atccttgaaa atcagcattt gacgatctta agaaatgtaa 1202761 gcgacagaaa gcggatggaa aaggagcttc gggaaagcga gctgaaattc agaaaagtgt 1202821 tcaacggatc aatggacggc aatgtattgt tcgacaatca atacaggatc atcgacgcca 1202881 acccgttagc aagccatatt ttgggcctgt cacatgaaga gatcaaacag cacagcctgt 1202941 tagatattat ttctgcttat gaaatagaaa atttggcatc accggcaagg cagattaatt 1203001 ttgatgaaat ggacaacgaa attccatttt tgctgagcag cggtgataac agaaaactcg 1203061 aattctcatt taaacggaat attattcaaa atatgaactt ggctatcttt aaagacgtaa 1203121 cagagcgaaa agaattggag gagcgcctgc gcaaatcaga tacccttcat gttgtcggcg 1203181 aactcgcagc cggtattgct catgaaatca gaaatccgat gactgctctt aaaggcttca 1203241 ttcagcttct gaaagggagt gtcgagggag actacgccct ttacttcaac gtgatcacct 1203301 cagaactaaa gcgcatcgaa tccatcatca ccgaattctt gattttagcc aagccccagg 1203361 ccattatgta tgaggaaaaa catgttaccc aaattatgag ggacacgata gaccttctaa 1203421 atgcgcaagc caatctcagc aatgtacaaa tgcaacttga tttaattgac gacattcccc 1203481 cgatttactg tgaaccgaat cagctgaaac aggtttttat caatatatta aaaaacgcca 1203541 tcgaagtgat gcctgacggc ggaaatattt ttgtaacgat aaaggcattg gatcaagatc 1203601 atgttctaat ctccttaaaa gacgagggaa tcggaatgac agaagataaa ttaaagcgac 1203661 ttggtgaacc gttttatacg acaaaggaac ggggaactgg acttgggctt atggtaagct 1203721 ataaaattat tgaagaacat caaggcgaga ttatggtaga aagtgaagaa gggaagggca 1203781 ccgttttcca tattacgctt cctgtcagac agaatgctga agaaagaagg aatgatgaat 1203841 gaactactat acgacagccg aaacgccgct cggtgaactt atcattgccg aagaggagga 1203901 ccggatcact cgtctatttc tcagtcagga agattgggtg gattggaaag aaacggttca 1203961 gaatactgag cataaggaaa cacctaatct tgcagaagcg aaacaacagc ttcaagaata 1204021 tttcgcaggc gaaaggaaga cattctccct gccgctcagc caaaagggca ctccttttca 1204081 gcaaaaagtg tggcaagcgc tggagaggat tccatatggc gaatcccgaa gctatgcgga 1204141 tattgccgct gctgtcggca gtccgaaagc ggtgcgcgct gtcgggcagg ctaataaacg 1204201 taacgacctg ccgatttttg tcccgtgcca cagagtgatc ggcaaaaaca gtgcgttaac 1204261 aggatacgcc ggaagcaaaa cggagatcaa agcatttttg ctaaacatcg agcgaatctc 1204321 ctataaagaa aaataaaaca tatggcacgt tccctttttt cacggccgac atatcatttt 1204381 attaagttaa aaaagttggt ctgatgaaaa aggaggacaa agcaattgaa gccgagccgc 1204441 tctgagaaac ttgccgtttt tgccgaactg tttgtgaaac tgcatatctt atcaagcgct 1204501 caaaaagatg aaatcatcaa tgttaacaaa aagaaacaaa aaaaccgctg actcggctcc 1204561 aaatgagcaa agtccagcgg ttttttaatg caccttttct cctttaaaca gctgttcaat 1204621 ctcttcttca tagtttccgg tcataatccc tttttctgtg atgattcctg aaatgagatc 1204681 atgaggtgta atgtcgaaag cgggattaaa gacaggcaca ttggatggag cggtccgaac 1204741 tccggaaatc tgcctgactt cctcgggatc tcgttcctct atcgggatat cagcgccgca 1204801 tttgaccttt gtatcaaatg tagataaagg tgcggcgaca aaaaacggaa tatcaaaggc 1204861 gtttgctaaa atagcaagac cgtatgtgcc gattttattt gccgtatcac cgttctttgc 1204921 aattcggtcg gctccgacga taacagcgga aatttgtttt tccttcatcg tatgggcggc 1204981 catgctgtct gtgatcagag tgacatcaat gcccccctgc atcagctccc aagcagtaag 1205041 gcgtgaacct tgcaggacag gccttgtttc acaggcataa atgtgtaatc ccaaatcttt 1205101 ttgtttggcc aagtaaaacg gagctagcgc cgttccatag cggcttgtcg cgattgagcc 1205161 ggcattgcag atcgtcatga tcctgtcgcc ttttttgaaa agctgcaggg cgttttggcc 1205221 gatcaaccgg cacgtttcct catcctcgac ctgaatctga atggcttcat ggacaaggtt 1205281 tgtttttgct tcatttacgg aaatcgcgtt ttcgaccgaa tgactcagtc tctcaagcgc 1205341 ccatgacaaa ttaatggcgg taggccgtga gctgtttaaa tattgtttga tgtcttccag 1205401 tctgcggcgg aattccgtga cattgtctgt ttcaatgtct ttggcagcaa gcgccagtcc 1205461 gaaggcagct gtaatgccga tcgccggagc gccccttact ttgagcgtga caatcgcatc 1205521 aaatacatcc tctttcgtcg tcagctccaa atattccgtc tcatcaggaa gcttttgctg 1205581 atttaaaatg gtaatagctg tttctttcca ttcaacagaa cgtggaacag caaatgaatg 1205641 ggtcatgaat agatcattcc tttacaagta acttaaataa ttcaataaca tctgttatcg 1205701 ttttgaattc cgaacgtttt tcgataaagg ctgtgccggt ttcgagcgcc aagcgttttc 1205761 tgccgattcg tttatcaaac ggcacgatcg tatccaggtc agctacatgg gcaaggccga 1205821 tcgtgcgtcg tatcagctca cagcccgcaa atccgattgc ttcttcaaaa atatggctga 1205881 gcgtatcagt gaggtaaccg tcgatgttgg cgtaaacatc cagactgtcc ttctgccagg 1205941 cttcactaaa cgtctcttca aacgtttccc agacctggtt gacatgttca tataacggct 1206001 ctctgtcagc cccgtcacgg ctgagtgcgt tcaaaaataa gttggcgata aattgcccta 1206061 catcaaagcc gatcggtccg taaaaagcaa actcaggatc aatcaccttt gtttcgtgct 1206121 cacttgcgaa aatgcttcct gtatgcaaat caccatgaat caacgtttct gcagacgtta 1206181 aaaatgactt tttcagctta gcggcttcga ttttaacgct gtcattattc caaagctttt 1206241 cgacaaaagg acgaagctct tcttcaaaat catttgtgtc atggtcgaag aaaggatctg 1206301 taaaaacaag tctttccgta atgtcgcata gctctggatt tgtaaactgt ttaacaagct 1206361 gttttttcac cttaggttca agcgcgtaat ctgatgagta gaaaagtgtt tttcctaaaa 1206421 attcaccgat gtgctgcgac agatgaggat agttttcacc ctcaatgagt ccttttcttg 1206481 cgatcttgag gtgagagaga tcctccatga cggtaaccgc catttccgta tcagaataaa 1206541 acactcttgg aaccaggtga ggcacatgct cgccctgacg gatgagagcg ctgctttcga 1206601 ttcttgcacg gtcgattgtc agcggccagc tttctcccac cacttttgca tacggaaccg 1206661 cctgtttaat gatcaatgct ctgtcatgtt cttgatcata aatatgaaaa acgtaattta 1206721 agttgccgtc tccgatctcc tggcatgtca gcgtgctttt gcttggaaat aggccaagct 1206781 tcaccgccaa cgccacagcg gagctttcat ttaacgtttc gtataaaggt gtttttgtga 1206841 ctcccatcat cataacctcc aattatgtaa ttaattaata tgtggccgta aaaaagcctc 1206901 cttctcagag agaaggaggc ttaacatcta tgtccgcctc tcttatctct cagatcagat 1206961 ctgaatggaa ttagcaccgt gccttaagag accagcgtct cggcgcgaaa aaaatgcgcc 1207021 ccatttcaca atggaattac ggtcggttgc ttttggggtc aaaaggccaa atccctcgcc 1207081 caactctcga taagagaata tattcacttg tttgacaatt ctaatttatc agttgatgaa 1207141 catggtaaca ggtaatttag ttagttgtca atatattttt taatataaat cttttctgat 1207201 atcatcgaaa acaggaatgc tctcccgaac ttctgcgctt tcttgaaggt cgatttccgc 1207261 tcggactatg ccttcttccc ggccgccttc agcaagtaca cgtccccatg gatcaataat 1207321 caggctatgt cctgcaaatt cattatccgg atttgaaccg gtacaattgc aggctgcgac 1207381 aaagcattgg ttttcaatgg cccgcgcaat aagcaggctt ttccaatgat caaggcgggg 1207441 aagaggccat tccgcagaaa taaacagcac gttggcgcct tttgtcgtat gttttctgat 1207501 ccattccgga aaacggatat cgtaacagat caatccagag cttttgacgc cgtcaagctc 1207561 aaagtatccg tcttcggaac cggctgataa atacagatgc tcatccatca gctgaaaaag 1207621 atgggctttt ctgtactctt taatgatttg cccttcctta tccgcgatgt acattgtatt 1207681 ataaacatca gaattcttcc tgacagcgac cgatccggcg acaatatgaa caccatgttt 1207741 ttttgccgtt ttcttcagcc agctctgagc ggagcggccg tcttcgtcag cgagttcatc 1207801 aagattggcc agatcatatc cggtcgtcca taattcaggc agaacaagaa catcagcatg 1207861 tttgctttct ttttcgatga aaaattcagc cttttttata ttttccgaag gttttccgta 1207921 tgaaatatca aattgaagac aagatatcgt ccatttcatc tttttaacac cccaaatttt 1207981 tctttacttt tttcatttaa ccatatatga tgatggacta tcatttcaag atttttttag 1208041 aaggtgagaa tagatgaaat ttgaacagtc tcatgtattg aaggaattgc ctaaacaatt 1208101 cttcgcttct ctggtgcaga aagtgaaccg aaagcttgca gaaggacatg acgttatcaa 1208161 tctgggacag ggaaatccag atcagccgac tcctgagcat attgttgagg agatgaaacg 1208221 agctgtcgct gatcctgaga atcataaata ttcgtctttt cgcggctcat accgtctgaa 1208281 gtcagcggct gctgcatttt acaaaagaga atacggcatt gatctggatc cggaaaccga 1208341 agtcgctgta ttattcggcg gaaaagccgg tctagtcgag ctcccgcaat gcttgttgaa 1208401 tcccggtgat acgattttag ttcccgatcc gggttatcct gattactggt cgggtgtcac 1208461 acttgcaaaa gcaaagatgg aaatgatgcc gctcgtaaag gacagagcgt ttctccctga 1208521 ttacagcagc ataaccgctg aaataaggga acaggcgaaa ttgatgtatt tgaattatcc 1208581 gaataatccg actggagctg ttgctacttc cgagttcttt gaagataccg tgcgttttgc 1208641 ggctgaaaac ggaatctgcg tcgttcacga ttttgcttac ggcgctgtag gatttgacgg 1208701 ctgcaagcct ttaagctttt tgcagactga aggtgcgaag gatatcggaa ttgaaattta 1208761 cacgctgtca aaaacgtata atatggcagg atggcgggtt ggctttgccg tcggaaacgc 1208821 ttcggtcatt gaagcgatca atctttatca agaccatatg tttgtcagtc ttttcagagc 1208881 gactcaggag gctgcagcag aggcactgtt agccgatcag acgtgtgtgg cagagcaaaa 1208941 tgccaggtat gagagcagga gaaacgcttg gatcacggca tgccgggaaa tcggctggga 1209001 tgtaacagct cccgcaggtt ctttttttgc atggctgcct gtgcctgaag gctatacttc 1209061 tgagcagttc tcagatcttt tgctggaaaa agcgaatgtg gcagttgcgg ctggaaacgg 1209121 cttcggtgaa tatggcgagg gctacgtcag agtcggactt ttaacaagtg aagaaagact 1209181 taaggaagcc gcttatcgaa ttggcaaact gaacctgttt acccaaaaaa gcattgacaa 1209241 gaccttataa cgatgggata attcaaaata atttataaaa tctatatttt cttatcaaga 1209301 gcaggcagag ggacgagccc gatgaagccc ggcaaccgac ttataaagca cggtgctaat 1209361 tcttgcagct agcggctgag agataagatt cggacgagaa acgaaacctc tttagacgcg 1209421 attgcagttt gaagaggttt tttgatatgg atgaaaatga aaggagctct ggcatgagtg 1209481 agttattagc gacatatctc ctgaccgaac cgggagccga tacagagaag aaagcagaac 1209541 aaatcgcaac aggattgaca gtaggctcct ggactgatct gccccttgta aaacaggagc 1209601 aaatgcaaaa gcacaagggg cgggtgataa aagttgagga gagagaggga actgctgcat 1209661 cagaaaaaca agcggtcatc acaattgcct atcctgaaat caatttctct caggatattc 1209721 cggctttgct gacaacagtg tttggcaagc tgtccctgga cggaaaaatc aaattaatcg 1209781 atcttcactt ctctgaagca tttaagcgtg cactgccggg accgaagttt ggcgtatacg 1209841 gcatccggaa gctgctggga gagtttgaga gaccgctgtt aatgagcata tttaaaggcg 1209901 taatcggaag ggacctgagt gatattaaag aacagctccg gcagcaggcg cttggcggag 1209961 ttgacttgat taaagacgat gaaattttct ttgagactgg tctagcgcct tttgaaacaa 1210021 gaattgcaga aggaaagcaa atattgaaag aaacgtatga acaaaccgga cataaaacgc 1210081 tgtatgcggt gaatttgacc ggacgtacgg ctgatctgaa agacaaagcg agacgcgccg 1210141 ccgaattggg agcggatgcg cttttgttta atgtcttcgc ttacggcttg gacgttatgc 1210201 aaggccttgc agaagatcct gaaatcccag ttccgattat ggcgcatcca gcagtgagcg 1210261 gagcgtttac gtcttctccg ttttacggtt tttctcacgc tcttttactc ggaaaattaa 1210321 accgatattg cggtgctgac ttcagcctct ttccgtctcc atatggttcg gttgcgcttc 1210381 caagagcaga tgcactggcg attcatgaag aatgtgtgag agaggatgct tttaaccaaa 1210441 catttgctgt tccgtcagca ggcattcatc ccggcatggt tccgctatta atgcgtgatt 1210501 tcggcataga ccacattatt aacgccggag gaggcgtaca tggacatccg aacggtgccc 1210561 aaggcggggg gcgagcgttc agagctatta ttgatgcggt cctagaggcc cagccgattg 1210621 atgaaaaagc cgaacaatgc aaggatctta agcttgcgct agataaatgg ggaaaggctg 1210681 aagccgtatg acgactcgaa aaccttttat tatttgtgat tttgacggaa caatcacgat 1210741 gaacgacaac attataaata tcatgaaaac atttgctccc ccagagtgga tggcattaaa 1210801 agacggcgta ctttccaaaa cgctgtcaat caaggaaggt gtcgggcgga tgttcggcct 1210861 tctgcccagc agtttaaaag aagagattac aagttttgta ttggaagatg caaaaatcag 1210921 ggaaggcttt cgggaatttg tagcatttat caatgagcac gagattccgt tttatgtcat 1210981 aagcggtgga atggactttt ttgtatatcc tttgcttgaa ggcattgtgg agaaagaccg 1211041 catttattgc aaccatgctt catttgacaa tgactatatc catattgact ggcctcattc 1211101 ctgcaagggc acatgcagca atcaatgcgg gtgctgtaag ccgtcggtca tccatgaact 1211161 ttctgaaccg aaccaatata tcatcatgat cggtgattcg gttacagatg tggaggcagc 1211221 aaagctgtct gacctatgct ttgcaaggga ttatttatta aacgaatgcc gggagcaaaa 1211281 cctcaatcat cttccgtatc aagattttta tgagatcaga aaggaaattg agaatgtaaa 1211341 ggaggtacag gaatggctgc aaaacaagaa cgctggcgag agctcgctga agtaaaacgg 1211401 gaattggcag agagagattg gtttccggcg actagcggca atctgtcaat taaggttaca 1211461 gatgagcctt taacatttct cgtcactgca agcggaaaag ataaacgcaa agagacggtt 1211521 gaagattttc tgctggtcga tcaaaacgga gagcctgctg aaagcgggca ttctctgaaa 1211581 ccgtcagcag aaacgctttt gcatacacat ttgtacaata aaaccaatgc cggatgctgc 1211641 ctgcatgtcc atacggtaaa caataatgtg atttcagagt tatacggaga ccaaaagaaa 1211701 atcacattca aaggccagga aattataaaa gcactcggct tgtgggaaga gaacgcagaa 1211761 gtgaccgttc cgattataga aaatccggca catatcccga cgctagcggc actgtttgcg 1211821 gaagagattt cagaagattc aggagctgtt ctgatccgaa atcatggtat tacggcttgg 1211881 gggaaaacag catttgaggc aaaaagagtg cttgaagcgt atgaattttt gttcagctac 1211941 catttgaaat tgaaaacact cgagcatcag ctggttaaat aaaaggagga attgaaatgg 1212001 ctacaattcg aattcatgat gaggcaaata caacgattga aaatcaagag gaagtggcaa 1212061 gctttctgga cagtcaagag gttatttatg agcaatggga tatcacgagg cttccggaac 1212121 atctctcaga gaaatatgac ctgacagaag aagaaaaaca gcaaattctt gataccttcg 1212181 aaactgaaat taaagatatc tcaacccgcc gcggctataa agcacaggat gttatttcat 1212241 tgtcagacag caatccgaaa cttgatgaac tgcttgaaaa ctttaaaaga gagcatcacc 1212301 atacagacga tgaggttcgt tttattgtaa gcggacacgg tatttttgtc attcaaggcc 1212361 aggacggcac gttttttgat gtccgtttaa accctggaga tttaatctcc gtgcctgaga 1212421 atatccgcca ttacttcacg cttcaggagg accgcaaagt tgtcgcggtg agaatttttg 1212481 tcacaactga aggctgggtt cctatttatg aaaaagacag cgtgaatcaa taagcgtgag 1212541 atagccccgt tcatcgaacg gggcttttta tatttattgc aaacgccact tttcatattg 1212601 tgacagttct tttttaatca gtgtccaaat caaacctaaa acagctgcat cgtcaatgaa 1212661 tccaagaccg aggattacgt ctggaatgat atcgagcggc atgacgatat acaggattgc 1212721 ggcagttaac agcaaaagtg ttttaacctg tgaacgaggg tagtcgccat ttcgccaatc 1212781 gcgaagcatc tgaaaaaaag tagtgatgtg ctggatacat ttttttcggt ttttcctctt 1212841 taaaatcgct tttccgcctg ccgctccgag cattattgct ttctttttct tcattgggca 1212901 tacctcctgc ctggcggcgt gtttaagata ttcttcacct gggtattgtt cttctaatcc 1212961 tatcaatata tctattatac ctgaaaaatt aacttattta atgaaaatat gtttacaaat 1213021 aaagtataat ctgtaataat gcacaataac ccaatcaaac ttgtttccta tttcttagcg 1213081 gcgaggggtg aagtgaatgg gcggttcttc tgaacaagaa agattgttgg tgtctattga 1213141 tgaaaaaaga aagttaatga tagatgccgc tagaaagcag ggatttacag ggcatgacac 1213201 gatcaggcac agtcaggagc tggattgttt aataaatgaa tatcatcagc ttatgcaaga 1213261 aaacgaacat tcccaaggga ttcaaggcct tgtaaagaaa ttaggcttgt ggccccgcag 1213321 agatgttatg ccagcatatg atgcaaataa atagcggcct atcagatgca tatataaaga 1213381 gagagctttt cggaagcgct ctttttttct ggaaaaaatt catatgaaag agggaactaa 1213441 tgaaggaact ggcgattctc attaccgaaa tggtcaatca atttcatgat gcttttattt 1213501 ccttatgcgg aatatttggc attcatttaa ctgacaaaga aatgcatttt tgggtgatcg 1213561 gcatttttgg catattcttt ttcggcgtca ctcacgctgt gtttacatgg ctttctaaat 1213621 ggagtatgac agccttgtcc tttatctata ccgttacagt catcattgtc atcgtatttg 1213681 cgattgagat tcagcaaaag gtgacgggga gagggaatat ggagttttta gatgccacgg 1213741 aaggtataaa gggtttttta gtatttttta tgtttttttt gcttttgaaa atgctgttgc 1213801 gtttcatcaa aatccttttt tctggaagac cagcaagcaa atcgaatggc aatgcccgat 1213861 cacgaagata aaaaaccctc ctgacatggt caggggggct atgatgcgga tacggggagg 1213921 gtgatcgtca cctctgtgcc tcttcgcccg ctgattgtta ttttgcttct gtgcctcttc 1213981 gcccgctgat tgttattttg ctcctctgtg cctcttcgcc cgctgattgt tattttgccc 1214041 tctgtgcctc ttcgcccgct gattgttatt ttgctcgcac tttgatttta tcatcttcta 1214101 aaatcacgtg aaaacttgtg atctcgccat tatcaagcag cagatcggtc atttcatcct 1214161 caacccattc ttggatggtt cttctaagcg gacgtgcacc gaatgaaggg tggtagccca 1214221 gctcagcgat tttttctttc gcttcatctg tcacattcaa gctaatgccc cgttccgcca 1214281 atgtttcttc aagttctcca agaagaaggc tgacgatttt gacaagatgt tctttttcca 1214341 atgagcggaa ctcaataatg ctgtcaaaac ggttgaggaa ctcaggttta aagaacatgc 1214401 tcagtgaatc aattaatgtt tgttcttcga tgacactgtc atctgattgg aaaccgactt 1214461 tcgtttgttt ctcaccagca cccgcattac ttgtcatgat gatcacagtg tctttgaagc 1214521 ttacagttct gccttggctg tctgtcagac ggccatcttc cataatttgc aggaacatat 1214581 gctgaacgtc tgggtgtgct ttttcaatct catccagcaa cacaatgctg taaggattgc 1214641 ggcgcacctt ctcagttaat tgtccagctt cctcatggcc gacatatcca ggcggtgaac 1214701 cgataatttt agatacggcg tgtttctcca tgtattcgct catatcgagt cggataatag 1214761 cgtcttttgt gccgaataat tcatctgcca gtgttttaga aagctctgtt ttccctacgc 1214821 cggtaggacc gacgaagagg aaggagccga ctggtctgtt tttggatttt aatccggcgc 1214881 ggcttcgtct taccgctttt gccacttttt gaacagcggc ttcttgtccg atcacgcgtt 1214941 catgaagttt tgcttcgagt tctttcattt tcgtttgttc gtctgcctgc agtttgccga 1215001 cagggatgcc tgttttttgt tcaacaattt cctgaatgtg ctcagcttcc acagtgacag 1215061 cggtatgagc ggaggagctg ttcagttttt tctccaatgc gagttcttca tcacggagtt 1215121 ttgccgccag ttcgtaattt tcttcttcca gggcttttgt tttttcggct tcaattgcag 1215181 ttaagcgttc agcggcatcc tcatcattca gttcatcaat taacaggttg gcttttgaac 1215241 ctgcttcatc taataaatca attgctttat ccggcaggtg tctgtcctga atgtagcggg 1215301 atgataaagt gacacatgct ttgattgctt catcactgaa tgttacgcca tggtacgcct 1215361 cgtatttgtc tttaatccct tgcagaatga ggatagcctg ttcaattgaa ggctcctgca 1215421 ccatgacagg ctgaaaacgt ctttccagcg cggcatcttt ttcgatttga cgatattctt 1215481 tcagtgttgt cgcgccaatg acttgcagtt cgcctctggc tagggccggt ttgagaatgt 1215541 tgccggcgtc cattgatcct tctgcagagc ctgcgccgac gagaaggtga atttcatcaa 1215601 tgaacagaat gacatttttt cgttccttca gctcagtgat cagctgtttc attctctcct 1215661 caaattggcc tctgatccct gtgtttgcaa caagagatgc aacatcaagc aagtatagct 1215721 ctttgttttt tagtttgttt ggaacatcac cttcagcaat ttttaaagcg agcccttcag 1215781 cgatggcagt tttccctaca cccggctcac caataagaac cggattgttt ttgtttcggc 1215841 ggtttagaat ttcgatcact cgcgccactt catcatcacg gccgatgacg ggatcaatga 1215901 gaccggcttt tgcaccgttt gtaatatttt gagccagctc atcaagcaac cctttttttt 1215961 cgctttgttt tgctgcgctc tgttctttcg gctggaatgc ctgttcaaac ggaaatccga 1216021 aagattgagg acccatactc attgaaggtt tacgggtcag ttcgttatag caagtttcac 1216081 aaagaaccat ctgtttatga acggaattta tttgcatgtt aaggcgaatc gtcgcctcgt 1216141 tttgatgaca atgttgacaa cgcatttgcc aaaacctcct taataatttg atcatctttg 1216201 accaatgaaa gtgaataaaa aggtctattg ggtttgacct tctttgacta ttagtatacg 1216261 gcaaacttaa cggcattcaa accaatatgc tcaaagcaga ctgaatattt gactatcttt 1216321 gaccaattga tttttaaaaa aggccggttt gtttgaccaa ctttgattaa tagtatactc 1216381 tgactatctt tgactttcaa gtcttatgca caaaaatttt tgatttgtta caaagtaaaa 1216441 catgttttct tcgtcttttc aaggaacttg tctcataggt tataaaaagg catatatgga 1216501 caaaactgcg gttcgttcgg agggaagaaa tggaacaatc aaaagggtct gcaagtcagc 1216561 ttgcttttgt gtatgtcggc acagtagtcg gagctggatt tgcgactggg agggaaattg 1216621 ttgagttttt tctgaagttc ggctggttcg gttttttcgg cattctcgtc agcggcggaa 1216681 tgtttacgtt actgggggcc aagctgatga tcatttcaaa gcgaatcaat gccaagtcat 1216741 atcaagaaat gaacatattt ttgttcgggg cgacggctgg gcggattatc aatgtattta 1216801 tgctgtttgt tctccttgga gttacatctg ttatgctttc aggggcaggg gcgctttttg 1216861 aggaacagct ggggatgtcc gctcagattg ggatgctcat tacaatcggt ctgagtttaa 1216921 ttgtgatgac tagaggagta aaaggcattt tcggtgtcaa tgtgtttgtt gttcctcttt 1216981 taatcatctt ttcaatgatt gtggtggccg actcttttat attcagcgaa tcacgaaacg 1217041 cagctcagtg ggtctggccg catcgctggg attggctgtt atcagcagtt tcttacgggg 1217101 ctttaaattt atcgcttgcc caagctgttt tggttccgct ggcgaatgaa atgtcatcgg 1217161 agaaagtgat aaaaaaaggc gctttaatcg gaggcacgat gctgacgatt gtgctgtccg 1217221 cgagttttct gtctttgtcg actcttccgg atgtattttt gtatgatata ccgatggcgc 1217281 aagtggttta tctctttgca cgatctgtcc atttgattta tttactcatt attttcggag 1217341 aagtgttcac atcagttatc ggtaatctat atggattaga aaaacaagtg caaagctttc 1217401 ttccagtgaa aagcaaatat atctttgcag ccattatgat cacggcttat attacgagcc 1217461 aaatagggta cggcaggctt atttcaacga tttatccctt gtttggctat gtgagcctgg 1217521 ccttcatagg cgctttgctt tgcaaaaaag ctcctcggcg gcgcagttta taaatatata 1217581 taatgaaacg aaccgtcact atagagcgat aattgatcta ggaaccgggg actgactttt 1217641 ttattgtcaa gaaaaacatc attatggtaa gatagcagaa gtgaaaaaat tgaagaaaat 1217701 ccgtgcgata tgcgggagag gttctagcta caccctctat aaaaaactaa ggacgagctg 1217761 tatccttgga tacggccttt tttatgtttt tctagagcac cttccgaaaa aaggtgtttt 1217821 tttgcgtgaa ttagctgtag cgatgtctct cgccggcgtt tttattgcgg agaaggagag 1217881 gaatcatgaa aaaagaaaaa gcaattgtcg tatttagcgg cggtcaagac agcacaacat 1217941 gcttactgtg ggccttaaaa gaattcgaag aagtcgaaac ggtgactttt cattataatc 1218001 agcgacattc gcaggaagtt gaagtggcaa aatccattgc ggaaaagctt ggtgtgaaaa 1218061 atcatttgct tgatatgtca cttttaaatc agcttgcacc gaatgccctg actagaaatg 1218121 atattgagat agaagtaaaa gacggcgaac tgccatccac attcgttcca ggccgcaatt 1218181 tggtattctt atcctttgcg tctatcctgg cttaccaaat tggcgcgcgc cacattatta 1218241 caggagtttg cgagacagac ttcagtggtt atcctgactg ccgtgacgaa ttcgtgaaat 1218301 cttgcaatgt cacggtaaat ctggcaatgg agaagccgtt tgtgatccac acgcctctca 1218361 tgtggctcaa taaggcggaa acgtggaagc ttgcagatga gcttggcgcg ctggattttg 1218421 tgaaaaacaa cacgctgaca tgctataacg gcatcatcgc agacggctgc ggcgaatgtc 1218481 cggcatgtca ccttcgttca aaaggttatg aagaatatat ggtgatgaaa ggagagcgtg 1218541 cataaattgt tatctcaaat ttatccgcag gcccagcatc cttattcgtt tgaactgaat 1218601 aaggacatgc atatctcagc cgctcatttt atccctcggg aaagtgcggg agcgtgcagc 1218661 agggttcacg ggcatacgta taccgtaaat ataaccgttg ccggcgacga acttgacgat 1218721 tcaggctttc ttgtcaattt cagcgtactc aaaaaactgg tgcacggaaa ctatgatcac 1218781 acgctattaa atgatcatga agatttttct caggacgacc ggtattcgct gccgacaact 1218841 gaagtcgtgg cgaaaacgat ttatgacaac gtacaggctt atttagacac tttggagaat 1218901 aagccgacct gtgtacaggt gtttgtccgt gaaacaccga caagctactg tgtctaccgt 1218961 ccgaaaaagg gtggtttgaa tggctaaagg aattcctgta ttagaaattt tcggcccgac 1219021 gattcaagga gaaggcatgg tgatcggaca gaaaacgatg ttcgtccgga cagccggctg 1219081 cgattattcc tgcagctggt gtgactccgc tttcacttgg gacgggtctg ctaaaaaaga 1219141 tattcgctgg atgacggcgg aggagatttt tgcggagctt aaggacattg ggggagatgc 1219201 gttttctcat gtgacgatct caggcggcaa cccggctctg ttaaaacagc tggatgcttt 1219261 tattgaactg ctgaaggaaa ataacatccg tgcagcgctt gaaactcaag ggaccgttta 1219321 tcaggattgg tttacgctga ttgatgacct gacaatttct ccaaaaccgc caagctcaaa 1219381 aatggtaacg aactttcaaa agcttgacca cattttaact tcacttcaag agaatgatag 1219441 acagcatgct gtcagcttga aggttgtcat ctttaatgat gaagatctgg aatttgccaa 1219501 aactgtgcac aagcggtatc cgggaatccc gttttattta caagtcggaa atgatgacgt 1219561 gcatacgaca gatgatcagt cactgattgc acatttgctt ggaaaatatg aagcgcttgt 1219621 tgataaggta gctgtcgatg cggagctgaa tctcgtcaga gtgctcccgc agctgcacac 1219681 cctgttatgg ggcaacaaac gcggagtata atagaaagga agatgaacat gacgacaaga 1219741 aaagaatcag aattagaagg tgtaacattg ctaggcaatc aaggtacaaa ttatttgttc 1219801 gaatatgcac cggacgtgct ggaatccttc cctaataaac atgtaaaccg tgattacttt 1219861 gtaaaattca attgcccgga attcacatct ttatgtccta aaacaggcca gcctgacttt 1219921 gcgacaatct acatcagcta cattcctgat gaaaaaatgg ttgaaagcaa atcattaaag 1219981 ctgtatctat tcagcttcag aaaccatggt gacttccacg aggactgcat gaatatcatc 1220041 atgaacgact tgattgaatt aatggacccg cgctacattg aagtatgggg caaattcacg 1220101 ccaagaggcg gaatttccat tgatccgtac acaaactacg gaaagcctgg cacgaagtat 1220161 gagaaaatgg ccgaataccg tatgatgaac catgatttgt atccggagac aattgataat 1220221 cgttaattat tccgttgtgt gatacggagt gtaaaaggaa gtggagtcac agtaaaatcc 1220281 gaacattcag cgttaatttt cagcggaaat gtgacctggt cacagcgaag tgtgacccgc 1220341 actaagctca ataaaagtgg gaaaagtcac acctgaaaat ggctctactc atgggaattg 1220401 tattaaaaag tgtgacctga ggtgcaacct gaactgtgac ttttatgcag tgaaaaattg 1220461 atagtacaga agcagattaa ggcgtacaat ttgtacgtct tttctttttt atccgaaaga 1220521 aaaaatgcct atctagagat cataggcatt aaatattatt atcaatatct tcatttattt 1220581 tttggctaag tttctgaacc ttctctttaa catttgaaac agctcttttt tgaatttcat 1220641 caattctcct gaatatagtc gatgacactt cttattagaa cttcactttc aaaattgaat 1220701 atctcattta tttctgactg ttcttcatct gttaggtgat ggtattgaag ttgtttagca 1220761 tttacttcag cagctacatc aatcctaact tagttgttct ggttgtacaa tttcatattc 1220821 accttctgca tactcttgct ccgcataata gcctccccat tgacagagct cctgcaagat 1220881 aggtttaaga gattctccaa gttcagtgga tgaatattca accttcggcg gtacttgatt 1220941 atacatcttt ctgctcacaa gtccactggc ttcaagctct ctaagtgttt gaatcagcat 1221001 tttctgagtt atatttggga taatgcgctt taattcactc gttctctttg gtccattcat 1221061 taaaaagtat aatacaaggc ctttccattt tccgccaata acttcctttg tcacttcaaa 1221121 cccacagcta aattttttca tgtctaaagc tctccattcc acatttatta ctttttagtt 1221181 actatatcac aaaaaagtgg gtacttccga taatgtgctt actgaaggat actatatctt 1221241 gtaagttgtt cttcaagtac ttaaaggtac tagacataaa ataaaattaa ttctaaagga 1221301 gtgttaagta tgggtaaatt tgaaggtaaa atagcgcttg taacgggtgg aacaagtggg 1221361 attggtcttg ctacagcaca aaaatttgta aacgaaggtg catatgttta tattacggga 1221421 cgtagacaaa acgaacttga taaagctgtt aaccaaattg gcaagaacgt aaccggtgtt 1221481 caaggtgata tttctaagct tgaagactta gacaaactat atgacattat aaagcaggaa 1221541 aaaggtaagt tggacattct ttttgctaat gcaggcatcg gcaacttcct tccattaggt 1221601 gaaattactg aagagcaggt tgatagaacg ttcgacatta acgttaaagg aaccatcttt 1221661 actgttcaaa aagcgttatc actattcccg gacaaagtag gttctattat tgtaacgggc 1221721 tctactgctg gatcaattgg caacccagcg tttagtgtat atggagcatc taaagcagca 1221781 ttaagagcac tagttcgcaa ctggattctt gacctaaaag gtactgaaat ccgtgtaaat 1221841 gtggttagtc caggaggtat tcttacacct gcctacgatg agctttttgg tgatgcactt 1221901 gaagaggtac tggaaaatag cagaaatact gttccagctg gaaaagttgg gacacctgaa 1221961 gaagtagcaa acgctgtatc tttccttgct tcagacgaaa gcagttactt gacgggtgtt 1222021 gaattgttcg tagatggcgg gctagcacag gtataatttc actgcgcaga gattacaaat 1222081 agtccccaaa aaaggttaat ggggatttac ttgaagaagt cgtataaaaa agtcgttttc 1222141 cttaaaggac agggaattcg acttttttat atttgaattt gattaacgtt gtaaattcgc 1222201 attttcctgg ggctactact aaatgacctg taaaaaagat tacactgtga ataaatgtac 1222261 ttaaagtaac gggggctctt gacttttaat aaaaaataat atccctgtcc ttgtattcta 1222321 atacttttaa aaatatttaa aggaatcctt atgtcctgaa taaccacata ggaaaatatg 1222381 ttgtaggttg ctttcttttt ttgtggggca tcccacacaa gctatctcgt gatctcacac 1222441 ctgaacgttt tttatagact agtaccgcga caagttatat tacatataca taccaataaa 1222501 gtagacatta aaaagtgaaa gagaggatgg aaatgtgtga aaattctttt ccttgagagt 1222561 catcccatgt ggctctatgg tttaccgaat gggtttaggg aagcaggaca taccgtaatg 1222621 atttccggtc ctgtaagtcg ggaaaatata actgaaatga tagacgaatt taaaccagat 1222681 ttaatagtat ctatgggatg gacaccagag cattcaaggg aaaagcaggc ctggattcgc 1222741 aacgctacta aaaaggtgaa tatccctctc gtttattggg caactgaaga cccgctgcac 1222801 actcaaaact ttactatccc gttaattaaa aagatgaaac cggattttgt tttcacggtc 1222861 acgccttctc tgtgtaaaac ttatgaaagc atggggatta aagcagctca cttagacttt 1222921 gcatttcacg aaagtataca tcaccagatt aaaccattag cgaaatacag ttgtgatata 1222981 gcagtggtgg ctaatgctta ccctaatttt cttgaagaac atccggaagt gttccgttcg 1223041 tcctctttaa aaacgcttat tcgtcctctt atacggaagg gtattcgcat tgatttttgg 1223101 gggagaaact gggaaaaaat gagtaaatat ataggaagag aaattccccg caattggatc 1223161 catggatacc ttgattatac tgaagcatat aaagtttaca gttcagcaaa aatcattatc 1223221 ggtttgcaaa actgtgaaag ccaacttaca caacgcacct atgagattct tggttccggg 1223281 gggtttttat tgacatcgga tacaccagca gttcgaggta aattcaaacc tggccgcgat 1223341 ctcatcgttt cttcctcccc aaaagaaaca ttggaaaagg ttaaatacta tttaaatcat 1223401 gatagcgaga gaaaaaagat tcagataaac ggtaaaaagg ctgtaaagaa tgattcctat 1223461 cggcatagag ccgagagaat gcttgaggtg ctaaaaagca gaggaatcat aagaaactta 1223521 ggggaaacca ttcattatgt agatgttctc aaagaaaaat acgtgatcca tcatgttact 1223581 cccggtgaaa cattatcaat aattgccagt aagtataatg tttccctgca gcaactcatg 1223641 gagcttaatc atttcaaatc agatcaaata tatgctggac aaatcattaa gattagagag 1223701 aaactgttta gaaatattaa taacaaatta ttctaaagga gagtaatatg aatgaagggg 1223761 aaaataccta aaataagaaa tcaagcgaat aaagtaaaaa gaacgcctcg ttatatggaa 1223821 tttcccgtga catacgaagt atatcatgtg gaatccggcg atacattatg gacgattgcc 1223881 aaatcctttg aaattccggt acaacaactt atgaatctta ataagctttc ttcagataga 1223941 atttatcctg gacaaattat aaagataaga gaaagataat ctttgaggtt tcggaagcga 1224001 atcaaattga aatgacaatc ctcatttttt tatttgtggg gaacttgata tttttgggga 1224061 tgaaggggtt atgagatgtt tcaaatgagc tattactatt ctggattagg atgggacttt 1224121 attcaacacg ttgatcaaac gaacggagta ttaaatgttg tgtctcctga ttttttctat 1224181 atcagaaaag atggatcatt acttctccgt tcagctaatc ccgatgtgat taaagctctt 1224241 catagaagaa aattaaaagt agttcctttt ctaagcaatc attgggatca ggatttggga 1224301 cgatttgcat taatgaaccg agttctttta gctaaacaaa tttctcatgc aatagaagaa 1224361 ctggatttgg atggagttaa tatcgatata gaaaacctta cagaaaaaga tcggaatcta 1224421 tttacagatt ttattagatt agtaaggaaa agtattccta gacataaaga agtatcagtt 1224481 gcagtggcgg caaatccttt tggctggacg aagggctggc acggatcata tgattacgag 1224541 tatttagcta aatatgcaga ttatcttatg gttatggcct atgatgaaag ccgccttgct 1224601 gggcctactg caagtgtagg atgggtggaa aagtccattc aatatgttct gacccaaaaa 1224661 atctctcctc aaaaactagt tttaggattg ccattctatg gccgctgctg gatggaaggc 1224721 caatctgcct ctcaagccat tcccctttac cttgttgtta gtaaaaaggc atagcgggac 1224781 aattattttt gacaccaaga gtcaatctcc aaaagctatt tttactgtca atcacgataa 1224841 aaaggggccg ttgccttcgg gaacatatac attatggttt gaaaatgaac agtcactcag 1224901 agcaaaaata aaactcgctc aaaaatataa tctgaaaggt cttggcagct ggagtcttgg 1224961 acaagaagat gcgtcagtct ggaatacagt gtttaaaaat atataatgat ttatagttca 1225021 gaacaaaatt cgaagataat tgcaatgaat ctctaaatgg acatactgaa aggagtttat 1225081 tacgagtgcg ggtaaaacag tgagggcatt ccataggccc ttctcccaaa atgttctaca 1225141 cgaggcatta cattgggctt gaaatacaca ttcaaactta tgttatagta cgcattttac 1225201 ggatgtgttg aatttattct gcttccatga tttaatcata cacatgctac ttgatagcag 1225261 ggttatcgca tttcattcag aattgttcag gatcgatatg gaagcgcacg actaactaga 1225321 actttaaaag catacactca tatacttcct gaatggatgc tggtttatct aaaaaacatg 1225381 atgagaattg attgtacgca tggtgaagca tgacttgttg ataatcgacc atatggtttc 1225441 tccttagaaa tgagggggtt tttacataaa aaagacgagc gaatccgggg ggaattccac 1225501 tcgccgcttt ctaatgaaaa gacgggatgc tggatggcag ctcgtctgtt ttattataat 1225561 ttaacgaacg tatgtttgta aaggtgtctt ttcgaatgaa ttggttcata taaccgttaa 1225621 gaacagattc attgtaaaca ttcgctaagg tatgctaaga tgcatggact ataaaggagt 1225681 gatatgaagt gaagacattg cggttaaaca atgtaacgtt agaaatggct gcatatcaag 1225741 aggagagcga gccgaagcga aaaattgcat ttaccttaaa cgttacgagt gagacttacc 1225801 atgatatcgc tgtcctgttg tatgaaaaaa cgtttaatgt cgaggttccg gaacgcgatc 1225861 ttgccttccg gggggaaatg acaaattatt caacatcatt gaccaacctg tacgaaccag 1225921 gggccgtcag cgagttctat atagaaataa cggaaataga caaaaacgcc gattcatgat 1225981 cggtgttttt tatgtaaaaa agctgccggc cggcagcttt tgagaaagcg aatttcatat 1226041 gtaaggtgtt aaattgtccg tcttgcagtt ttttgaataa atgtggaaat aaggaggttt 1226101 taataggagt ctctgatgat cttataattt ttatgattaa caactgtcaa tgaatctaac 1226161 tcaagatccc gatagttatc catgatcgtc acatcaacga taacagaatt ctcatttact 1226221 ttttcaacaa caccggttaa tccgttttta aattcaatga cattcccaac cttagcgatt 1226281 ttcacaagct tcctctcctt taaacataat aatgcctttt gaaagtattt tgcagtattt 1226341 tcattgagaa gtaaagcgat aaggagtttt atctccctta tgaattgttc tgtcgctata 1226401 aagatgatat attgattttc gtcaatagaa agaaaagggg ggaatttttg ttgcgtcccg 1226461 aagaaataac agaaatgatt gaacagctgc gcaccggcgc cataaacgaa ctgagagtcc 1226521 agaaagagca ttttcttgat ttcagggccg tgttatctaa acaagatgat tttaaacatt 1226581 tccgaggaat tgcccagcaa ggcggagatg ttatctttca atacttagaa cagccaagaa 1226641 gctgaaggtt tctcatacgt gagaagcctt tttatcatat atgacagaac acaagccttt 1226701 tattacagct gtctgtaaca ggtgtaaata aaatgtaaag taccaaagat ggataaacat 1226761 gttttaattt aacaatattt atagaatttc agactgtttt tttgccatta agcagtgagt 1226821 catcctcttt attccatcct gatacctcct tgggagagtt ggaaaatctt tttccgtgaa 1226881 aatgaatgga tctcttgtta aggttatgaa gtgttttttg gagcacttta aggaggaaac 1226941 tgtatgacaa cgaaattcac tgctctggct gtttttcttc tttgtttcat gcctgcagcc 1227001 aaaattgagc atacacaagc ttcactactg agcgcaaaga agacaaaaca tgaagaagcg 1227061 aaatggctta cacatataga tcgaaatacg aatgaatctt tcccttcact gtctgctgat 1227121 aaagacaaga aaataaaacc gattaagcta tcagcacaca ctgaaaagaa agagaaagat 1227181 aaaccggaca aaacaaatga tgagaaagaa acatatacac agtctgaaaa agagttgctg 1227241 tcccgtctcg ttcacgcaga ggccaaagga gaatcatata aaggcaaggt cgctgtagca 1227301 agcgttgtac tgaacaggac ggagaaaaaa ggttttcctg atacgataag aggagttatt 1227361 tatcagaaaa acgcctttga accggtcgca aacgggagca ttaaccaaaa gcctgataaa 1227421 gaatcgattg aagctgccga agaagcgctg tcctcaaaaa atagagaaac agatgccata 1227481 ttcttttata atccgaaaac agcgtcagat aattggattc gttcaagaaa aatcgtagaa 1227541 aaaatcggca gacacgtttt tgccgtctaa gcatagaaga gacaatttgt ctcagctgtg 1227601 ctttttttca tataaagagt aaaaataaaa taatttttga acttgtctca tatgatgttg 1227661 gtagtacaag agacaaggag agacatcatg aatcgatttg tgaaagggat cattctttta 1227721 tccattgccg cctttttcgc tgaatgcctt gaatttgtcg tcaatatgat tttggcgcgg 1227781 gagcttggcg agcatgggat ggggctttac atgagtattt tgcccacgat ctttttaatt 1227841 attgtcatcg cgagcctgga actgccgata tccatttcta aattcattgc cgagtcaaat 1227901 cctaagcttc atgaaagcat gctgaggcac gctttcagaa tgacagccat ttttactgct 1227961 ttttctactg ccgccgctag tattgcgctt ccgtttattc cggtatttga tacataccac 1228021 ccgtttatta aagggattgt catcggctta attcctgttg tcgcctttac ttcaatcgcc 1228081 aggggctact ttatgggtgt gcagaaaatg gggaagatcg caattgccaa tgtgctgaaa 1228141 aaaatcatcc agctcttgtg cttattcctc ttttttcaat ggtactcatt tgaattggac 1228201 atggctgtgc tgatttcctt gtttgttcta gtcgtgagtg atgtggtcgt gcttgtttat 1228261 ttatattcac aatttatcat ggcaaggcgg gcgttatccg gccagcagca cattcatttg 1228321 cgcggaaagg atgtaaggaa aagactgctt gctgtttcaa ttcctacaac aggactgcgt 1228381 atttttcatg cggttgtcaa tgcaattgaa ccctttttag taaaaggagc tcttttggct 1228441 gcgggcgttg ccgggacagc ggcgatcgat caatacggaa tgctggcagg agtggctgtg 1228501 acgatagggt cgttccctgc ttttattgcc cattcgttaa tggtcgtcat gataccgagt 1228561 atttcggaag cttatgcact ttctcagtat gacatcgtgt taaaaaggct gaagcagtcg 1228621 attttcatta cattaggtta cggtatacct gccgtctggg tcatgttcca gtttgcggga 1228681 cctctcacgc atttgttttt tcactctcct gaagcgcagt attacttgca gctgttgtgg 1228741 ccttactttc tctttcatct gtttgtcatg ccgctgcagg cgtgcttaat cgggatgggt 1228801 tttgtgaaag aggcttttta tcacaatgta tggagccata tcgttgcgct aagtatgatg 1228861 tatgtactgg gatcaatgga gaatctgcaa atgctcggga ttatccttgg aatgaacact 1228921 ggcatgattc ttttgacgag cctgcactat gccacgatct gcaaagcatt gaaggtatct 1228981 gtatttctta cgggagggac cagaacgccg cgaattgaag gatgataaag gaacagcagg 1229041 ggcaagctaa ttgaaaagca tgaaaggaag attccatgtt gacgaagcgc ttgcttacta 1229101 tatacattat gttattaggg ttgattgcat ggtttccagg tgcggcacaa gctgaggaaa 1229161 aacagcctgc tgttcccgct gtttttctta tgaaaacgat agaaggggag gacatctcga 1229221 ttccgaataa agggcaaaaa acaattctcc atttttggac gtcatggtgc ccgccctgca 1229281 aaaaggagct tccacagttt caatcgtttt atgatgccca tccatccgac agtgtaaagc 1229341 tggtaacggt gaatttagtg aattcggaac aaaatcagca agtcgttgaa gactttatta 1229401 aagcaaacaa gctgacgttt ccgattgtcc ttgactcaaa aggggaattg atgaaggagt 1229461 atcatatcat cacgatccca acatcatttt tgctgaatga aaagggagaa attgaaaaaa 1229521 caaaaattgg cccgatgaca gcggaacaac tgaaggaatg gacggaagaa tagctgagag 1229581 catagactct cagctttttt catatagaga agaagtgaat aaacattaat gataattatt 1229641 atcaaaaaga aattaaaata attataattg aaattctctt cgtgcgtgct ataataaagg 1229701 aagacatcaa gaaataactg acgataaagc tgccttttgg gcagcgattt tgtttttata 1229761 agagaaatga agatgattta cgttctcaat tagagaggag aattcgatat gaatgaacaa 1229821 gttatcgttc aacgcgaccc gcatgagcca ttgaaaacag acaagaggga aaaaaactgg 1229881 gcacagcacg cggagcttat tgcagcactt gtatcaggcg ctcttatttt ggcaggctgg 1229941 ctcttatccg gatatcaggt attatccata atacttttct tgctggcttt tgtgatcggc 1230001 ggatttgcta aagcgaagga aggaatcgaa gaaacactcg aatccaaaac gctgaatgta 1230061 gaacttttaa tgattttcgc tgccattggt tccgccttga tcggatactg ggcagagggt 1230121 gctattttaa tatttatttt ttccttaagc ggagctttag aaacatacac gatgaataaa 1230181 agcagcagag atttaacgtc tttaatgcag cttgagcctg aagaagcgac attgatggtc 1230241 aatggtgaaa ccaaaagagt tccggtttca gacttgcagg ccggtgatat gattgtgatc 1230301 aaacctggag aacgcgtagc ggcagacggt atcattgaat cgggctcgac aagtcttgac 1230361 gagtcggctt taacaggtga atcaatgcct gtagaaaaaa acacaggcga cactgtattc 1230421 acaggaacgg tgaatcgcaa tggctccttg acagtccgtg tcacgaaagc aaatgaagat 1230481 tcgttattca gaaaaattat caaactggtt gaatcagcgc aaaatagtgt ttcacccgcg 1230541 caggctttca tcgaacgatt tgaaaatgct tatgtgaaag gtgtgctaat tgcggtggcg 1230601 ctccttttat tcgtcccgca ctttgcgctg ggctggagct ggagtgaaac cttctaccgc 1230661 gcaatggtgt ttatggttgt cgcgtcacct tgtgcgcttg tcgcctctat tatgccggcg 1230721 gcgctgtccc tgatttcaaa tggcgcccgc aacggtatgc ttgtgaaagg aagcgtcttt 1230781 cttgaacagc tgggctcagt gcaaatgatc gcctttgata aaaccggaac tgtaacaaaa 1230841 ggccagcctg ccgtagagac gatcagaata gcagaaggat tcagtgaagc ggaagttctt 1230901 gaggctgtct atgccatcga aacgcaatca agccatccgc tcgcccaagc cataacggcg 1230961 tacgctgaaa gccgcggcgt gaatcagtcc ggctacatat ctatagaaga aacctcaggg 1231021 tttggcgtta tggcagaagt gtcgggtgcg aaatggaagg tcggtaaagc aggttttatc 1231081 ggcgaggaaa tggcagcaca atttatgaaa caaacagcat cagatgtcat tcaaagcggt 1231141 catacaattg tatttgtgaa aaaggatgat caaatagcag gctgtatcgc actgaaggac 1231201 caaatcaggc ctgaagcaaa agaggtcatg gaagaactga accgacttgg gattaaaacg 1231261 gccatgctga caggagatca cgaagacacg gctcaagcga ttgccaagga agccggcatg 1231321 acaactgtcg tggcagaatg cctgcctgac caaaaagtga atgaaatcaa acggttaaaa 1231381 gaagaattcg gaacgattgc aatggtgggt gacggaatca atgatgcgcc ggcactcaaa 1231441 gcagcggatg tcggcattgc gatgggcggc ggaacagatg tagcacttga gaccgctgat 1231501 atggtcctca tgaaaaacga tttgaaaaag ctcgtaaaca tgtgccgctt gtctcggaaa 1231561 atgaacagga tcatcaaaca aaatatcgtg ttttctctag ctgtaatctg cctgctgatt 1231621 tgtgcaaact ttttgcaggc gatggaattg ccatttggcg tgattggtca tgagggcagc 1231681 acgattttag tcatactaaa cggtttaaga ctcctaaaat aaaaccagca gcctaatcag 1231741 gctgctggct ttttatgtat caagctttcc cttcattttt gtctttatca gatcttttca 1231801 taactaggat gagagcgagg gtgcagcaaa ggaaacccgc tgcacagcct atgatagagc 1231861 tgtaataata aaagcccacc atcttcatcc cgataaaagg agcggaaatt cccaaaaccg 1231921 ttaagagcat aactgctttt cgtctgaaaa aattcatcag caaacggaac aacccccctg 1231981 cgattgaacg ttactgtcag tatacaggaa gaggagcagg aaataaaatg cattagaaaa 1232041 tgaaggcgtc gtgaaaggca aacaccggta aaacctgtta caatggaaga cagaacaatg 1232101 cattgcaaat ggcagggagg aacaagaagt gaatagaata caacgcgtct cttcatggct 1232161 gaaggaagcg gggcatactg ccgcatttat tcatacgaaa gaaaatgttt tttacttaac 1232221 cggtttttac acagagccgc atgaaagatt aatggggtta tttatttttc aagaagagga 1232281 gcctttcttt gtttgtccag gaatggaagc aggacaggcc cgcaacgcag gctggaatca 1232341 tgaaatcatt ggctatgcgg atcacgaaaa tccgtgggag ctgatagaga aggctttgaa 1232401 aaagcgaaat atcagcatac atatgcttgc ggtagaaaag gattcaatct cgctgtcacg 1232461 tgcagaacag ctgaagcatg cgacgggcgg ggctcaattt gtttcagcag aagaaacact 1232521 caatcaattt cgcctgatta aagatgacaa tgagattcgt ttgctgaaag aggcggcaaa 1232581 gcttgcagat tacggtgttg aagtcggcac agccgctttg cgtgaaggca tcagtgaagt 1232641 ggaagtgctc gctcaaattg agtatgagct gaagaaaaaa ggaattcagg gcatgtcttt 1232701 ctctacaatg gttttattcg gagaaaaatc tggccagcct catggaaatc ctggtacagc 1232761 cacgttgaag aaaggtgatt ttgttttatt tgatctcggt gttattcttg atggctattg 1232821 ctctgatatt acaagaacgt ttgcatacaa aaccatcaat ccgaagcagg aggccattta 1232881 cgagactgtg cttcaagcgg aaaaagccgc gattgaggca agcaaacccg gtgtgagaat 1232941 cggagatctg gatttaactg cccgcggaat cattgaaaaa gcgggatatg gtgattattt 1233001 tcctcaccgg cttgggcatg gactcggaat ttcagtccat gagtatccat caatgagcca 1233061 ggccaacgat acactgctgc aggaaggcat ggtctacacg atcgaaccgg ggatttatgt 1233121 gccagagatc ggcggcgtac gcattgagga tgacgttcac gtaacaaagg acggagcagt 1233181 tgctctgacc caatatccaa aggatttgat catactgtaa tagaaataaa aaaggacttt 1233241 gttctcgaca tcgtcctttt ttatctgcat taaataaaaa aatcatcaaa tgttcgaaag 1233301 ggtttaattt catgtttttg gttgagaggt tttacagcaa gacagctgcc accgagaaca 1233361 gtgagacata acccaattaa aatgaagaaa cccatgtgat cttctccttt cagctaaaaa 1233421 cacaaaaaga tatctggtac gtccatatca tattgtatga aacgcattcc agatcaaggg 1233481 gatttagaaa gaagggaatc tatggctaat attaaagaca ttgcagagaa agccggtgtc 1233541 tctgttacaa cggtttcccg agtcataaac aatcatccat acgtcagtga agacaaacga 1233601 aaaagagtgt ttgaggcaat ggaatcattg gagtacacga gaaatattca cgctgtacat 1233661 ttgtcgaaag gattttcaaa catgattggt gttgtcttgc cgacggttaa tctgccatat 1233721 tttgcagagc tgattgcagg aatagccgac gcagccgcgg aatccggggt tcacctctct 1233781 ttattccaaa caaactatga agtacaaaaa gaaatctttg cgctgtccca attaaagcag 1233841 cgccaggttg acggcctgat tttttgctca aaggcgcttg ctgatgagaa actcatggaa 1233901 tgggagggcc cgattttgct ttgccagaat tcagataatg cccgcttccc aaccatcagc 1233961 attcctcacc aagaagcatt tcggaacggc ttggactatt taattgccaa agggcacaaa 1234021 aaaatagcca tctgtttggc aagaaaaaaa ggcatgaaca gccattttcg aatcaaagcc 1234081 tacaaagagg cattggaaga gatcggcgag gcatttcgtg aagactgggt aattgagaaa 1234141 gcgattacaa tcaatgatgg gaaggcgctt tttcataaat ggaatacgtg gaaggaaaag 1234201 ccgacggcta tttttgttgc caatgaccaa gtctcagcag ggctttttct tgaagcaaag 1234261 aaccagcggg tgtcagtacc ggatgagctt gcaatcttaa gcgttgataa ccacgaaatc 1234321 agccaagcgc ttggaatcac aacgatcgat attcagacaa gggaaatggg aaagcaggca 1234381 tttgccatat tggaaaaaag aattcaagga cagccgattg aaaggaaagt tctggattac 1234441 cgtctcatcg aaagatcgac tgtttagtga atgcattgaa aaaaggtttg acgtgcattc 1234501 tgttcgttat gtacgatatg aggtattgaa tgacaaagga gctgaggatc gtgaatgggt 1234561 ccttcacagt gaaaaaggta ctgaataata acgtattaat tgcttctcat cataaataca 1234621 gcgaagtcgt tttaatcgga aaaggtattg gtttcggaaa aaaacaagat gatgtcattg 1234681 aagataaagg ctacgataaa atgttcattt taaaagacga gaaggaacaa aagcagttta 1234741 aaaagctcct tgactatgtt gatgaaaagc tcgttgatat ttcaaacgat gtcatctatc 1234801 acataagcaa taggacgaat cactcattaa atgaacatat tcacattgcg ttgacagacc 1234861 atatcgcatt tgcgatcaaa aggcagcagc agggatttga tatgaaaaat ccatttctaa 1234921 tggagactca gtcactatat cctgaggagt accaaattgc caaagaagtc atagatatga 1234981 tcaatgaaaa agcgggactc tgccttccgg aaggggagat tggttttatc gctctgcata 1235041 tccattcagc gttgacaaac cgtccgctgt ccgaggtcaa tcagcactct cagctcatgg 1235101 cgcagcttgt cgaggtgatt gaagactcat ttcaaatgaa agtaaataag gaaagtgtca 1235161 actatttgcg gctgatcagg catatcagat ttacaataga aagaattaaa aaagaagaac 1235221 cgactaaaga accagaaaaa ttaatgttgt tattgaaaaa tgaatatccg ctatgctaca 1235281 atacagcttg gaaattgatt aaaatcttgc agcaaacatt gaagaaacca gttcatgagg 1235341 cggaagcggt ttatctgacg cttcatctgt accgattaac caataaaatt tcataaattc 1235401 agtttatcct tataacgtgt tactgattcg atcaggcatg agtgattgag ggaaaaaaac 1235461 gggaagttca ttctcgttct tttgcgcacc caattttgct catgcctttt tgttgtgtaa 1235521 aagggcaaat gtaaacggtt aaactggaag acttacgcct gtgaattcgt tgtcatgatt 1235581 tttagctgta aggtcagact agtaaaaaga ggaggtcaat tcttatgttt aaagcattat 1235641 tcggcgttct tcaaaaaatt gggcgtgcgc ttatgcttcc agttgcgatc cttccggctg 1235701 cgggtatttt gcttgcgatc gggaatgcga tgcaaaataa ggacatgatt caggtcctgc 1235761 atttcttgag caatgacaat gttcagcttg tagcaggtgt gatggaaagt gctgggcaga 1235821 ttgttttcga taaccttccg cttcttttcg cagtaggtgt agccatcggg cttgccaatg 1235881 gtgatggagt tgcagggatt gcagcaatta tcggttatct tgtaatgaat gtatccatga 1235941 gtgcggttct tcttgcaaac ggaaccattc cttcggattc agttgaaaga gccaagttct 1236001 ttacggaaaa ccatcctgca tatgtaaaca tgcttggtat acctaccttg gcgacagggg 1236061 tgttcggcgg tattatcgtc ggtgtgttag ctgcattatt gtttaacaga ttttacacaa 1236121 ttgaactgcc gcaatacctt ggtttctttg cgggtaaacg tttcgttcca attgttacgt 1236181 caatttctgc actgattctg ggtcttatta tgttagtgat ctggcctcca atccagcatg 1236241 gattgaatgc cttttcaaca ggattagtgg aagcgaatcc aacccttgct gcatttatct 1236301 tcggggtgat tgaacgttcg cttatcccat tcggattgca ccatattttc tattcaccgt 1236361 tctggtatga attcttcagc tataagagtg cagcaggaga aatcatccgc ggggatcagc 1236421 gtatctttat ggcgcagatt aaagacggcg tacagttaac ggcaggtacg ttcatgacag 1236481 gtaaatatcc atttatgatg ttcggtctgc ctgctgcggc gcttgccatt tatcatgaag 1236541 caaaaccgca aaacaaaaaa ctcgttgcag gtattatggg ttcagcggcc ttgacatctt 1236601 tcttaacggg gatcacagag ccattggaat tttctttctt attcgttgct ccagtcctgt 1236661 ttgcgattca ctgtttgttt gcgggacttt cattcatggt catgcagctg ttgaatgtta 1236721 agattggtat gacattctcc ggcggtttaa ttgactactt cctattcggt attttaccaa 1236781 accggacggc atggtggctt gtcatccctg tcggcttagg gttagcggtc atttactact 1236841 ttggattccg atttgccatc cgcaaattta atctgaaaac acctggacgc gaggatgctg 1236901 cggaagaaac agcagcacct gggaaaacag gtgaagcagg agatcttcct tatgagattc 1236961 tgcaggcaat gggtgaccag gaaaacatca aacaccttga tgcttgtatc actcgtctgc 1237021 gtgtgactgt aaacgatcag aaaaaggttg ataaagaccg tctgaaacag cttggcgctt 1237081 ccggagtgct ggaagtcggc aacaacattc aggctatttt cggaccgcgt tctgacgggt 1237141 taaaaacaca aatgcaagac attattgcgg gacgcaagcc tagacctgag ccgaaaacat 1237201 ctgctcaaga ggaagtaggc cagcaggttg aggaagtgat tgcagaaccg ctgcaaaatg 1237261 aaatcggcga ggaagttttc gtttctccga ttaccgggga aattcaccca attacggatg 1237321 ttcctgacca agtcttctca gggaaaatga tgggtgacgg ttttgcgatt ctcccttctg 1237381 aaggaattgt cgtatcaccg gttcgcggaa aaattctcaa tgtgttcccg acaaaacatg 1237441 cgatcggcct gcaatccgac ggcggaagag aaattttaat ccactttggt attgataccg 1237501 tcagcctgaa gggcgaagga tttacgtctt tcgtatcaga aggagaccgc gttgagcctg 1237561 gacaaaaact tcttgaagtt gatctggatg cagtcaaacc gaatgtacca tctctcatga 1237621 caccgattgt atttacaaac cttgctgaag gagaaacagt cagcattaaa gcaagcggtt 1237681 cagtcaacag agaacaagaa gatattgtga agattgaaaa ataagggtgt tagtacgccg 1237741 tgcttgtcag atgacaagta cggttgtatg atataatatt gtgaagtaat aaagctttaa 1237801 gttaaaagga gaatgataaa aatggcacaa aaaacattta aagtaactgc agattctgga 1237861 atccatgctc gtcctgcgac agttcttgta caaactgcta gcaaatacga cgctgacgtt 1237921 aatttagaat ataacggcaa aacagttaac cttaaatcta ttatgggtgt tatgtcttta 1237981 ggtatcgcta aaggcgctga gatcacaatc tctgcttccg gagctgacga aaacgatgct 1238041 cttaacgctt tagaagaaac aatgaaaagc gaaggactcg gcgagtaatg caagaattaa 1238101 aagggattgg tgcttcagcc ggcatcgcga ttgcaaaagc gtaccggctt gaagagccag 1238161 atttaacggt tgaaaagaaa aacatctctg attctgaagc ggaagtaagc cgttttgatg 1238221 aagcgattgc acgttcaaaa gaagagctcg aaaaaatcaa agagcacgct ttgaaagaac 1238281 tgggtcagga taaagctgat attttttctg ctcacctttt agttctcagt gaccctgagc 1238341 ttctgaaccc tgtgaaagaa aaaatcagca ctgattcagt gaacgctgaa ttcgctttaa 1238401 aagaaacgtc ttctatgttc gttactatgt ttgaatctat ggacaacgaa tatatgaaag 1238461 agcgtgcggc agatatccgc gatgtaacaa aacgcgtaac cggccacctg cttggcgtcg 1238521 aaattccaaa cccaagcatg atctcagaag aggttattat tgtagctgaa gacttaacac 1238581 cgtctgacac agctcaatta aaccgtgagt tcgtaaaagg attcactact gatatcggcg 1238641 gacgcacatc tcactctgcc atcatggcac gttctcttga gattccagca gttgttggaa 1238701 cgaaagctgc tacaggcacg atccaaaacg gcgtgactgt tatcgttgac ggtatcaatg 1238761 gcgatgtcat tattgaccca tctgcggaaa ctgtaaaaga gtatgaagaa aaacataatg 1238821 cttatttggc tcaaaaagct gagtgggcga agcttgtcaa tgaaccgact gtctcaaaag 1238881 acggacatca tgtagagctt gcagcgaaca tcggtactcc tgatgatgta aaaggtgttc 1238941 ttgaaaacgg cggagaagca gttggccttt accgtacaga attcctttac atgggaagag 1239001 atcagctgcc tacagaagat gagcagtttg atgcttacaa aacggttctt gagcgtatgg 1239061 aaggaaaatc agtcgtcgtg cggacacttg atatcggcgg agacaaagag cttccttacc 1239121 tgcagcttcc taaagaaatg aacccgttcc tgggatatag agcgattcgt ctttgccttg 1239181 aagagcaaga aatcttcaga acacagcttc gcgcgctgct tcgtgcaagt acatacggaa 1239241 acttgaaaat catgttccct atgattgcga cagttaacga attcaaagaa gcaaaagcga 1239301 tccttcttga agagaaagaa aagctcgtaa aagcgggaca ggctgtatct gacgatattg 1239361 aagtcggaat gatggttgag attccgtcaa ctgcagtcat cgctgatcag tttgctaaag 1239421 aggttgattt cttcagtatc ggaacaaacg atttgattca atacacaatg gcagctgacc 1239481 gtatgaatga acgtgtatct tacctgtatc agccatacaa cccggcaatc cttcgcttaa 1239541 ttacactggt aattgaagca gcacacaaag aaggaaaatg ggttggcatg tgcggagaaa 1239601 tggcaggaga cgagattgcg attccgatcc ttctcggctt aggcttagat gagttctcaa 1239661 tgagcgcaac gtctatcctt ccggcaagaa cacaaatcag caaattgtct aaacaagaag 1239721 ctgagtcatt caaagagaaa atcttatcta tgagcacgac agaagaagtt gtcgcgttcg 1239781 taaaagaaac attcaagtaa tgtacaaaaa ccagacggcc tccggcctgt ctggtttttt 1239841 tcataagtaa gggtatagaa ggacacaata acatggctag gagggatagt atgtcaaacc 1239901 aatttaacgc aggagatact gtttatgtga tctacagaaa tccgcacgcc gccaatgtag 1239961 cccacataaa ggaagccgaa attgtgcacc atccatacca tgaaggcgag ctttccctgt 1240021 ttatttatga aacctatcat ccattcgcag aggacgatgc tgtgtttgca agctatgaag 1240081 aagctaaatc gctttacaaa gaactgtttg atattgatcc gtatgagtaa caaggaaatc 1240141 attacaactc atatcctttc cgcctagtga gaaaagtaac gttagtaaag gaaaaggatg 1240201 tggcatcatg cagaacccat ttgttccgca gcttgtgtat atagaaccga gggcgctgga 1240261 atatccgctg ggccaagaat tacaagataa atttgagaat atgggtattg aaatcagaga 1240321 aacgacatcc cacaatcagg tgcgtaatat ccctgggaaa aatcatcttc agcaatatcg 1240381 caatgcgaaa tcaactttag ttatcggtgt ccggaaaaca ttaaagtttg attcatccaa 1240441 accctcggcc gaatatgcca ttccgtttgc aacaggctgc atggggcatt gtcattactg 1240501 ctacctgcaa acaaccatgg gatcaaagcc gtatatcaga acttatgtaa acgtcgaaga 1240561 gattttagat caggcagata agtatatgaa ggagcgcgca ccagagttca caaggttcga 1240621 agcatcatgt acgtcagaca ttgtaggaat tgatcatctg acacacacgc tgaagcgcgc 1240681 cattgaacat tttggccaaa gtgatctcgg aaagctccga tttgtaacga aatttcatca 1240741 tgtcgatcac ctattagacg caaagcataa cgggaaaacg agattcagat tcagtattaa 1240801 tgccgactat gtgattaaaa actttgagcc gggaacttca cctcttgata agcggataga 1240861 agcggcagta aaagttgcaa aagcaggcta cccgctaggc tttattgttg ctccgattta 1240921 tattcatgaa ggctgggaag aaggatacag acatctgttt gaaaagctag atgctgcttt 1240981 gccgcaggac gttagacatg acattacgtt tgaattaatt caacaccgtt ttacaaaacc 1241041 ggccaaacga gtgatagaga aaaattatcc gaagacgaag ctcgaattag atgaagaaaa 1241101 gcgccgttat aaatggggcc gttacgggat cggaaaatat atttatcaga aagatgaaga 1241161 gcatgcactt cgagaggcac ttgaatccta tattgatacc tttttcccta acgcaaaaat 1241221 tgaatatttc acttaaacgg gctgttgtga tcaacagctc gcttttttat aaaaaacatt 1241281 tttccattcc atcaaaacgc cgtaattcaa tgattcttta tcctccaaat aattgctgac 1241341 tacacgaata ggtgaacgcc cgcaacggag gagaaaggac agcacagggt cgtttttcct 1241401 gccttccatc acatcttcaa cgtactgaac agcgctgatc tcgtgtgcgt atttataata 1241461 caaaggaatg cggccgccgc cgagaaggcg ttccagtctt ttatcaacag tcagctcata 1241521 catcgtattc atcagccatt ttccgattcc aagctttcga taatgaggag aaacagaaat 1241581 atccactaca tataaagtat ttccatgagg ttcatgattt ttaatcgatc cgttgtcagt 1241641 tgcttgtgcc catgtatgat caggagaatc aggctcaaat tgtacaataa gagcagtcat 1241701 ggaaccgata attctgccat tgatgagcgc gcataaagcg ccttccggaa aggttttgat 1241761 atggctggca agctggtcct ctgaccacag caattcctgg ggaaacggag gagggaaaca 1241821 ttcttcttga agagaaatca gcctctcgat gtcagtctca gtgtagtttc taatggtcag 1241881 agcctcaaat tttctgccgt catgcacata catttgtttt agtatgatca tcactctcct 1241941 tatgttgttt cattataacg aagattgaat tttcagtaaa tatattccga ttttcttata 1242001 atttattttt tgattattca tttttcaaac gaaagggccg atatagaaat taggagggga 1242061 ttggtttgtt taaaaaactt cacatgaaga ttgctgtttt tgtttcgatt atgttaatca 1242121 tcacagttgt tctcttaatg ctgtcttctt atttgacgct aaaaccgatg attacagagg 1242181 atgggaaaaa tacaactcaa aacgtgacgc agtcacttga acaaaatatt gaattgcaat 1242241 taaagagtta tgccatttcg ttatcaagat tggctaatgg ggaattaacg catacatttg 1242301 taacgaaacc aagtaaagaa gcttctcggc tgtttcacga tgacattaag caaatcaaag 1242361 acaacgatga ttatgttgcg atggcttaca taggcaccgc aaaaaaagaa atgtttacat 1242421 atccaaaagc ggatttcgct gaggattacg atccaacatc aagaccatgg tataagcttg 1242481 cagctgaaac cccggatcaa gttgtttgga cggaacctta taaagatgtc gtgacaggag 1242541 acatgattgt tactgcatcg aaagcgatct tagacaggca aaaagtgata ggggttgcca 1242601 gctatgactt gaaactctct gctatccaga gtatggtcaa taaacaaaag gtgccttaca 1242661 aaggatttgc ctttttagct gatgcgagcg gcaatctttt agcccatccg tcaaatcaag 1242721 gaaaaaatat atcaaaggat caaacactgc aaaccatcgc atccgagaaa aaagggatac 1242781 aagatgtgaa tgggaaaatg gttgtgtacc aaacgattgg cgagacaggc tggaaggtcg 1242841 gaacgcaatt tgataccgat caattaatgt ggatttcaga taaaatgaat cgggccaatc 1242901 tttggatatc attgattgcg cttatcataa caattattct cagctacttc ctggccaaaa 1242961 cgataaccgg tccgatacag cagctgatcg taaaaacgaa agctgtttcc gcaggcgatt 1243021 taacagtgcg cgcggaatca aaatctaagg atgaagtcgg tattttaaca agagatttca 1243081 atctgatggt tgaaaatatg aaggaaatgg ttgagcaagt gagactctct tcagggaaag 1243141 tatctgacac ctctgaacaa ctaacggctg tggctgccga aactaatgaa acaagcggac 1243201 aaattgcaaa agcgattgaa gaagtagccg caggggcatc ggaacaggct tctgaagttg 1243261 aaaccattaa tgaaaaatcg gaaagcctgt caacgaaaat caggcaaatc gctgaggagg 1243321 caggcggaat taaagaacgc tcaaaatcgt ccgaggatgc aagctataaa ggacttgacg 1243381 cgctcggcca gctgctgatg aaatcaaacg aagccaatat ggaaacgaaa aaggttgaaa 1243441 cgatgctgct ggatttggaa aatcaaacta agaatattga agaagtcgtt acagcgattt 1243501 caaacatatc tgatcaaacc aacttgcttg ccttaaatgc cagtattgag gcagccagag 1243561 ccggagaaag cgggcgcggt tttgccgtcg tagccgatga agtgcggaag ttagctgagc 1243621 aatcagccct ttctacaaag catatcagcg agactgtgaa gcttatccag cttgagacaa 1243681 aagaggcctc tcacgcgatg gttgaggcaa gcagaatgaa tgatgaacaa aacagtgcaa 1243741 ttcacgaaac tggagaggta ttaaatacga taactgcaga aatgcagtca ctggtacaag 1243801 gtattgatca catttacgcg gaaattcaaa gaatgagtga agaacagctt gcgatttctg 1243861 aagccattca aagcatttca gccatatcac aggaatcagc tgccgcagca gaggaagtga 1243921 acgcatcaac cgatgaacag cttgtcaccc ttgataaagt caaacactca acggaaacac 1243981 taaaacatgc aagccaagag cttatgaaca caattgcaaa attcacattg taatccaatt 1244041 acatccccaa acatcatttg ttttggggat tttttatttt ataagatgaa tagatatggt 1244101 agtctagaaa atgaaggaaa aatgataaat tttaactaaa atctaaacga aacatctggg 1244161 aggaatgacc ttgaaaaaaa caattggttt tatcggtctt ggagtaatgg gaaaaagcat 1244221 ggcatcacat attctcaatg acggccatcc tgtattggtg tacacccgga caaaagaaaa 1244281 agcagaaagc atacttcaaa aaggcgcgat ctggaaagat acggtcaaag atctttcgaa 1244341 agaagcggat gttatcatca caatggtcgg ctatcccagt gatgttgaag aagtgtattt 1244401 cggaagcaat ggaattattg aaaacgcaaa agaaggtgca tatcttattg atatgacgac 1244461 atctaagcct tcgcttgcga agaagattgc tgaagcggcc aaagaaaaag cattgttcgc 1244521 tttagacgct cctgtttccg gtggagacat cggtgcacaa aacggaacac tcgcgattat 1244581 ggtcggtgga gaaaaagaag cttttgaagc ctgcatgccg attttctctt taatgggaga 1244641 gaatattcag tatcaaggac cggctggaag cggacagcat accaagatgt gcaatcagat 1244701 tgcaattgca gccggtatga tcggtgttgc tgaagcgatg gcttatgccc aaaaatcagg 1244761 cctagagccg gaaaatgttc tgaaaagcat cacaacgggc gcagccggaa gctggtcatt 1244821 gtcaaatctt gctccccgta tgctgcaagg caactttgaa ccgggatttt atgtgaagca 1244881 ttttattaag gatatgggaa ttgcactaga ggaagcagaa ttaatggggg aagaaatgcc 1244941 aggcttgtcg ctcgcaaaat ctttatatga caagctagct gctcaaggtg aagaaaacag 1245001 cggaacacag agtatatata agctttgggt gaaataaaaa aagattgcct gtacgaaaca 1245061 ggcaatcttt ttttattatt ttccgatgaa ttgttgtgtc cagatgcttc cagactcaac 1245121 gtaaccaaca ccgatgtgag taaagttagg gtttagaatg ttttttctgt gtccttcact 1245181 gttcatccaa gcttttacta cttcttctgg tgtcttttgg cccttcgcaa tgttttcacc 1245241 tgctgttttg tagctgattc cgaaagattt catcatatca aacggtgagc cgtatgttgg 1245301 gctttggtga tcaaagtagt ttttgtcttt catatcctga gattttgcgc gtgcagattt 1245361 gcttaacgtt tcatcaattt gaagcggttt taagccttgt ttttgtcttt ctgcatttgt 1245421 aagttcaaca acttttttct catatgcact tacagatgaa ggtgcagacg ttgttgtgtt 1245481 tgttttttca gcagttgcgg gtgctttaga agcagtgttt tgatcagcag ctgctttttc 1245541 agtagtcttt tgtgcaggtt ttgccgtttc tgtcttttga acatcctgaa ctttcacgtt 1245601 agattgcttc gcatgttttt gaagaagctg cttcatctct ttttcgtttg cagcgtttaa 1245661 cgttttgata tttgtgttaa tatgcagttt tttcactgca tcgttaagtg acatgttttg 1245721 tactgtgttc cccgttttta ctgtaaccac aggctggcag gagagttctt tcgctgatgc 1245781 ttgctgtacg cccccgaatg tgaataatcc aaccgcagcg gcagcagata aaataaatgc 1245841 tttcttcatt agttcgtaac ctcctagagt tgtttgtttc tacagaaaaa tcataacata 1245901 gcttttttgt cataaagatt ccagcacttt cctttgacaa atagagattg tcattttcgt 1245961 aaagtaaatc cgttgaatca ctaagaataa gggaatcagc ggtatatatg attttatcgt 1246021 accgttacat agcttccttt tttttgaacc gttagttata ttttaatgtg tttttatatt 1246081 gacagctttt tttactcctt ttcgctgtaa caactattac aaaggtgtta caattaatct 1246141 cagtatatgt aaatatattg aatgatttga gaggggtaac cagaagtgac tgaaatagga 1246201 cgtgaaccaa agaaaaagag caaaggaaac agagcaatca gaatgaacct ttttttccta 1246261 gctgtctttg ttctattcac tgcattaatt tttaagctcg gggttgttca aattgttgaa 1246321 ggcgaacagc atgaagaaga cgctgagaaa tcaaatgcaa aaacagctta ctatcctgcg 1246381 cctcgcggga agatgtacga cagaaaccag aaagttgctg tcgacaacca gagcgttcca 1246441 gaaattgtgt atgtatcaac atctagcaca aaaacagaag ataaaatcaa aacagcgaag 1246501 cggcttgctt ctttcattca tattgatacc gaatttttga aggaaaggga tcttcgtgat 1246561 tactggatcg cagctcatcc gaaaaaagcc gccgctctgc ttaaggaatc agaaagcaat 1246621 ctgaaaggag accaggctta caagcttcaa atagagcgtg ttccggatca agaattaaag 1246681 gctattcagc aagatgacga agaaatggaa actgctgcga tatatacaag gttttcaagc 1246741 ggaaatgctt acgaacctca aatcgtaaag gcaatgaatc caaataagag caatagcaat 1246801 ggaaaaaacg gagcgctgct tgatgagaag aaaaactcct cgcaaagacc aaaaaatgac 1246861 ttaacatatg atgaaatttc cattgtttct gagcatttag aagaacttcc gggaatcgat 1246921 atcgtaaacg attggacacg aaaatatcct tatgacaaaa ccctttattc tgttttcggg 1246981 ggcgtcacga cacctgatca gggcctgctg agcgaccgga aagatttcta cttaacaaga 1247041 ggctatgcga ataatgacag ggtgggaaaa agttatttag agtatcaata tgaagaatat 1247101 ttaaattcgc ataaagaaaa agtggaatac gtagaagata ataaaggaaa tgtcgtcagc 1247161 caaaaaacca ttgataaggg cagcagggga tacgatcttc agctttcttt tgacatggag 1247221 cttcaggcaa aggtagaaaa gatcattgaa gaagaagtaa gaaacagccg tgcacgcgga 1247281 aattacatgc ttgacagagc ctttgccgta atgatggacc cgaataacgg cgatatttta 1247341 tcaatggcag ggaaaaagat agatttaaaa accaacaaaa ttgaagatta tgcgataggg 1247401 gcatttacca cccaatatga aatgggatca gcagtaaagg gggccaccgt gctagccggc 1247461 tatcaggacg ggatcccgca ttataaatat tatatcgatg ctccaatgct tttaggaacg 1247521 aatcttataa aaaaatctta tactaatatg ggaaccatca atgaattaac cgcattgcaa 1247581 aaaagttcaa acgtatatat gttcaatgtt gccatgcata ttgcaggcgt aacatacaag 1247641 ccgcatggat ctctcccggc tgatcagaac gatctactga aaatgagaaa ctattacagc 1247701 cagtttggtc tgggagtaaa gacaggtatt gatctcccgc aggaatcagc cggaatgcaa 1247761 accacaccta aaactgtagg aggattaatt ttagacttag caattggcca atacgataca 1247821 tacacaccgc ttcaaatggc tcaatacatc tcagtaatcg ccaatggtgg ctatcgtgtt 1247881 cagcctagaa tcgtcacaag tattcataag ccaggaaaaa aagaccagct gggtaaggcg 1247941 attgaacata ggaaacctaa agtactcaat aagattaata attcagagag cgatttgaaa 1248001 caagtacaaa caggcatgaa attagtcact tcttcaggga cagcaaaaaa tacgtttaca 1248061 gaagatgtat cagggaaaac gggaacagcg gaaacatttt actacggcac gaatcgcaac 1248121 tggtggggga aaaaaacata caatctgact tttgtcggct attacccgtc gaaaaaacca 1248181 aaagtggcct ttagtgttgt tgttccatca gtagatgatg atgataagat caataaaatt 1248241 attgccaaaa gagctatcca cgcctacgca gagctcgaaa aaaaacacag taaaaaataa 1248301 aaaacagggt gcacaactaa aagattgtgt gccctttctt ttattcaaaa attgacgttc 1248361 accataagaa tagaaggaga atactcattt tctagcgaat catactaggt aaaagtcaat 1248421 ctgtatatgt cgaaacacga tgatcatgca aaggagggat tctgtggaac aggatacgca 1248481 gcatgttaaa ccacttcaaa caaaaaccga tattcatgca gtcttggcct ctaatggacg 1248541 catcatttat atatctgcca actccaaact gcatttgggc tatctccaag gagagatgat 1248601 cggatcattc ctcaaaacgt ttctgcatga ggaagaccaa tttttggttg aaagctattt 1248661 ttataatgaa catcatctga tgccgtgcac ctttcgtttt attaaaaaag atcatacgat 1248721 tgtgtgggtg gaggctgcgg tagaaattgt tacgacaaga gctgagcgga cagaacggga 1248781 aatcattttg aaaatgaagg ttcttgaaga agaaacaggc catcaatccc taaactgcga 1248841 aaaacatgaa atcgaacctg caagcccgga atcgactaca tatataacgg atgattatga 1248901 acggttggtt gaaaatctcc cgagtccgct atgcatcagt gtcaaaggca agatcgtcta 1248961 tgtaaacagc gcgatgcttt caatgctggg agccaaaagc aaggatgcta ttattggtaa 1249021 atcgtcctat gaatttattg aagaagaata tcatgatatc gtgaaaaaca ggattatacg 1249081 aatgcaaaaa ggaatggaag tcggaatgat tgaacagacg tggaaaaggc ttgatggcac 1249141 acctgttcat ttagaagtga aagcatcccc gaccgtctac aaaaaccagc aggctgagct 1249201 gctgctgctg atcgatatct cttcaaggaa aaaattccaa accatcctgc aaaaaagccg 1249261 tgaacgatat cagctgctga ttcaaaattc cattgatacc attgcggtga ttcacaatgg 1249321 aaaatgggta tttatgaatg aatcgggaat ttccctgttt gaagcggcta catatgagga 1249381 tttaattggc aaaaacatat acgatcagct gcatccttgc gatcacgagg atgtaaaaga 1249441 gagaatccaa aacattgccg agcaaaaaac agaatctgaa attgtcaagc aatcctggtt 1249501 cacctttcag aacagggtca tctatacgga gatggtctgc attccgacga ccttttttgg 1249561 tgaagcggcc gtccaggtca ttcttcggga catctcagag agaaaacaaa cagaagaatt 1249621 gatgctgaaa tcggaaaaat tatcaatcgc agggcagctc gcggcgggaa tcgcccatga 1249681 gatccgcaac cctcttacag cgatcaaagg atttttacag ctgatgaaac cgacaatgga 1249741 aggcaacgaa cattactttg atattgtgtt ttctgaactc agccgtatcg aattaatact 1249801 cagtgaactg ctcatgctgg cgaaacctca gcaaaatgct gtcaaagaat atttgaactt 1249861 gaaaaaatta attggtgagg tttcagccct gttagaaacg caggcgaatt taaatggcat 1249921 ttttatcaga acaagttatg aaaaagacag catttatata aacggggatc aaaaccaatt 1249981 aaagcaggta ttcattaatt taatcaaaaa tgcagttgaa tcaatgcctg atgggggaac 1250041 agtagacatt atcataaccg aagatgagca ttctgttcat gttactgtca aagacgaagg 1250101 ggaaggtata cctgaaaagg tactaaaccg gattggagag ccatttttaa caacaaaaga 1250161 aaaaggtacg gggcttggat taatggtgac atttaatatc attgaaaacc atcagggagt 1250221 tatacatgtg gacagccatc ctgaaaaagg cacagcgttt aaaatttcat ttccaaaaaa 1250281 ataaaaacaa cggcttaaac gccgttgttt atcgtctgca ttgcttcacg tttttttaat 1250341 acaaataatt ctaaacggtc taggccttct ctcagcgtgt ccattgagca tgcaaaagac 1250401 agccttacat atccttcacc atatgttgag aacgagctgc ccggcacgag tgccacgcca 1250461 gcgtcttcca aaagagccat actaaaatca aatgaagtca ttccaaatga tttaatagaa 1250521 gggaagatat aaaacgcacc ggacggttta actacgtcaa gtcccatgga aacaagacgg 1250581 tcataaacat agtccagacg ttttttgtat tgttctctca taatcaatgc atcgtcaaag 1250641 ccgtttgtga cagcttcaag cgcggctttt tgagaaatgg atgaggcgca cgacacattg 1250701 tattgatgaa cctttaaaat gtgctttgca atgtctttcg gtgcaaataa aaatccaatt 1250761 ctccaaccgg tcatgctgtg tgattttgac aacccgttaa tgacaatcgt ttgatcccgc 1250821 aaataggttg cgatggagta atgcggtctg tcatatgtta attcactgta tatttcatca 1250881 gacaatacga agacatttct gccttttaag agagctgcga tgcttttcag ttcttcttca 1250941 gataaagtca cgccggtagg gtttgacgga taaggaagca cgacacactt ggtgttgggt 1251001 gtcagagcat cttcaatcag ccgggcggta agcttaaagc cgtgtgacgt agtatcaaca 1251061 atgacaggct tggccccgca caaattgata ataggttcat agcccggata aataggccct 1251121 ggcataatga cttcatcacc gggagataaa atcgtccgga atgcagcatc aatggcttgg 1251181 cttgcgcctg ttgtgatgat aatttcagat tcagcatcat agttgaaatc cgcttttttc 1251241 ttcatataaa gctgcacagc ttgtctcagc tccaggtagc cggcattcgg agtatatgac 1251301 gtcacgtttt catcaatggc tttttttgcg gcagctttca catgatgcgg tgtgaaaaaa 1251361 tcaggctggc cgattgtaag tgaaatgacg tcttcgtgtt gggctacaag attcgagaat 1251421 ttgcgtattc ctgaaatttc gatctctctt gctttcggat tcagcaaatg ttccataatt 1251481 catcacctta acaaatataa tgagtttatc ctattttacc actagctgat catttgtcac 1251541 ctttttaact gatatatttc gattgtatgc gccttttttc taaacatacc tttcttttca 1251601 gaaaaaaaga agacaaccag cgatttgatt gtctttattg tatcatgttc tattattgtt 1251661 tatatgtgcc aatttcatta atagccataa tcaaaatgaa ggtcttcgtg ccaaatcaga 1251721 tacggaggat gctcttcttg aaggtcagct gattctttct tcatattcag gtaagtttct 1251781 tcactgatat cctctaaaac agtcatttcg ttttctttaa atattactaa ggtacccatt 1251841 atttacaccc ttctttggaa aaatccttga ctattttatc actgttagtt ggaaagtcaa 1251901 tggttattag gaaaaaagtt tcttttttga ggaacgcggc ttgttgcctt cggaattcga 1251961 ttttgaagag ctgccattca ctttttacaa attacgccga tatatacagt acaatactga 1252021 atgcgaatag cgagggattg aattgtcgtt acaacaatac gaaattttat tggattctgg 1252081 tacaaatgaa ttagaaattg tgaagtttgg cgtgggtgaa aatgctttcg gaattaacgt 1252141 catgaaggta agagaaatta ttcagcctgt cgaggtgaca tcagtgcctc actcccatca 1252201 gcatgtagaa ggaatgatta aactcagagg agaaatcctc cctgtgatca gtctcttctc 1252261 attttttgga gtagagcctg aaggatcaaa agatgagaaa tatatcgtga ctgaatttaa 1252321 taaacggaaa attgtttttc atgtcggctc tgtttctcaa attcacagag tatcctggga 1252381 agcgattgaa aagccgacat cgttaaatca aggaatggag cggcacctta ccggtattat 1252441 taagctcgaa gacctgatga tctttttgcc tgactatgaa aaaattattt atgacattga 1252501 atcagattca ggtgttgaca cgtataatat gcataccgag ggcttcgatg aaagaagaac 1252561 tgataaaaag cttatcattg tagaggactc accgcttttg atgcgcctct tgcaggatga 1252621 attaaaagaa gcagggtaca acaatatcgc ttcgtttgaa aatggaaaag aggcatatga 1252681 atacattatg aaccttgctg aaaacgaaac tgatttatca aaacagattg atatgatcat 1252741 cactgatatt gaaatgccaa aaatggacgg acacaggctc acaaagctgc tgaaggaaaa 1252801 tccgaaaagc tcagatgtgc cggttatgat tttctcatcg ttaattacgg atgatctgcg 1252861 tcaccgcggc gaagttgtag gcgcagatga gcaaatcagc aagcctgaga tcagtgattt 1252921 gattaaaaaa gtggatacgt atgttattga ataaataaaa acagccgttg ccagaaagag 1252981 gcacggctgt ttttatttta aaagtaactc tcgccaagtt ttttaaagac cggtttatgg 1253041 taagctggct gctggcgatt tggcactagc ggcttttctt tcatgccgac atattcttgc 1253101 aataggtgtt tcgcttttgt taaagacatt tgagctttag gatttcgata cgattgatta 1253161 agtgtaccta aatgcggaag atgttcgaag tcttctttag ttggaggcat gtgaaaatag 1253221 tagtctccga ttgagataag cacgtccgat tgctgttggc tgaaccttgg attttttgaa 1253281 aaatgaagcc ctattttctt tcctttacct tctttgacaa gcttttgcaa agcccgtttt 1253341 ttcagcagat ataggtattt agggttgggg gcggtttttg catggcggtt cacagtgtaa 1253401 actgcttttg aaagattttc tacggttggc tgcagatctt tcgtatatgc atggtcgtcc 1253461 attatttctc tcctttgctc ttatcaattt ctatatgttt agattatact tttttaaagt 1253521 tgaaatgcaa atattgaatg taaaaatgcg cttttttcta agaaaaaaag cgcattttta 1253581 acctgcatta tacagatctt gccttctttt tcggctgttc ttgaaatgct tcctgaacat 1253641 tcacttccac agcctgagca ctgtattttg gcagtgcaat aaaataaaaa ataaaaacga 1253701 gcaggataat aacacccatg ccgtaataaa gataatcaat gtttgaaaca aacttaggga 1253761 ataacagcgc gactaagccg agtgtcaaag attgtgcaaa catcataaaa gggtcctgca 1253821 tgccgcttac acgtcccatc agttttggat gaacaatttt tggcatccac cctccgattg 1253881 caatgttgat cggtccgata cacattccca gtgcaaaagc tgccgcgtaa tacacccata 1253941 aaatattggt gtagccgagg acgaagatca gcaaacctgc aatgaaaatc ggtatcgaca 1254001 ttaaaaagtg cggcttcact tttttagaga tgagcgtgcc gattacgctt cctgccagaa 1254061 gcccaaaccc gagtgcgatc gtaaatacag acgtatgcca ctcataacgg tcaggcgcca 1254121 atccatattt cattgtaaac atcggcaata cggcgaatcc tccattgaca aatccaaaaa 1254181 tgaagaagcc aaaaataaga gatgccagca atttgttttt taaaatatag aggatgcctt 1254241 ctctaaagtc atttattgaa tccttaacag aagtctttct ccagctgaat gcaccgtttg 1254301 gctgtcgggc ttcttttgga atccggcagc tgcggatcag cagcccggaa atgataaagc 1254361 tgacaaaatc aagaataatg gcgccttcaa taccgattgt gttgtacata aacgcgccta 1254421 tgccgactcc aaacaccata aaaatgctaa aaagcatctg attaagccct gccgctttcg 1254481 cataatgctc cttcggcaga atggcttgta ccaaactgtt ttctgccgga aagaaaaact 1254541 ttgttacagc gcttctgata aataagatac aaaaaacaag aggaatattg ccggtaaata 1254601 aagtgaaaaa aagcacgaca gtcaggcctg ctctgatcca atcacaattt tctgccacct 1254661 tttttctatc aaaccggtcc gcgacgactc ccacgatcag aaatacaaat atggtcggaa 1254721 gagaatacat cagctccgcc aaggtcgtat atgaaggctg gctgctgaat cggtccagca 1254781 aaaaaaaagc aaaggccatg ttgcctactg tcgtgcccat ttgagaagcg agtgctgcga 1254841 aaaatagacg aacaaaatta cgatttttaa atatatccat aaaaacgctc cttaccctaa 1254901 aggtcccact ttatcatatt ataaaccgcc tgtttttgaa acaaataaga aaacattacc 1254961 ggttaatcgt gactctcgtt ccgtttggca caattgaagc aagttcgatc acgtctttgt 1255021 tatgcatgcg aatgcagcct ttagaaacag ccttaccaat cgaagcggga ttattcgtcc 1255081 catgtattcc gtagtgctgc tttgaaaggc tcagccaata agcgccaaat gggccgccgg 1255141 gattgcgctg gcggttaata atgtaaaact cgccagtagg cgtttgcgtt agtattttac 1255201 caacggcgat gggataggtt ttcattaccc gattatttag ggacagcgta agggtcttcg 1255261 ctccgattga gactgcgata tgatacggaa ttgtataagg gtccggcagt ccggggatga 1255321 ctatggactg tcccgcggtg agccctgcct gcagtgacgg attagcctgg agtaatgcag 1255381 ccgtgctgat tctgaaatca gccgcgatgc tgttcagtgt atcaccttgc ttcacctggt 1255441 acgtaagcag tttcctcatc ctcctttttt acttataagt attgatgagg agcccatcct 1255501 gctacattaa tttgtgcttt ttaaggtgaa gacagtgatt tcaggcttgg caagaaaccg 1255561 caaaggcagc ctggtcatcc cgaggcctcg gtttacgtaa atatgagtgc tgcccgtttg 1255621 atacattccc tctgtgtaga cttttccata tggaggcgta ataatcggtc cgtaaaaagg 1255681 cagctgaatc tggccgccgt gtgtatggcc ggaaagctga aggttcacgg gataatctgt 1255741 tgttttcaag gctgcatcag gttcatggac gagaagaatg gaaaaaagtc tgtcgctcag 1255801 ccttgaaagg gtgccttcat aatctgggtt tcccagcatt aagtcatcaa gcgaagcaat 1255861 ctcgattttg ctgccatctg cgagtgacaa tgtttgatag ccattgcgat ataccgtgaa 1255921 acctccggcc gtcatcaggc ttttgtaaac ggcagttcca tagcctccgt gatcatgatt 1255981 gccgtaaata caaagcttgc cgaagggagc attaagcttt ctcaataatg gaatgactgc 1256041 ctggtggtgc tggtacgtat caggattatc aataatatca cctgtaaaaa caatgagatc 1256101 aggtttagat tcattaattg taagaatgac agtttttaaa tcttcgagag taaagtaatc 1256161 actcaagtgt gcatcgctga actgcacgat tttaaaaccg tcaaatccgt gcgggatgag 1256221 agagcttttt attgtgtgtt cggttgtctc gatcatatgc ggctcgagat acctggcata 1256281 gccatatccc ccgccggccg ttaaagcccc ggcagcaaga gcgccgaaca ttccttttag 1256341 aaattgtctt ctggacatct ttttcatttc aaaccaacct ttaatagagt ttttctatta 1256401 tatcatctgt atctgataaa aatctcatat gagcatgtgc tgacagaggc agggatataa 1256461 tgatagaata ttattgaatg aataatcatt cacaattgga gggataaaca tggaaaaaaa 1256521 ggcggtaatt attaccggcg ggtcaagcgg catgggaaaa gcgatggcaa aaaaacaggc 1256581 tgaattaggg tggcacgtta tggtgacagg gaggaaccat gaggcacttg aggaaacaaa 1256641 aaaagaaatt cagacctttg agggacaggt cgcttgtttt caaatggatg tccgttccga 1256701 ttccgccgct tcagacatga ttaaagaagc ggtaaaagcc tttggccggc ttgacgcgct 1256761 gattaacaac gcggccggaa actttatttg tccggcagaa aagctgacgc ccaatggatg 1256821 gaaagccgtt attgagattg ttttaaacgg cacatttttt tgcagccaag cagcggcaag 1256881 gcattggatt gaccagaagc agcagggtgt cattttaaat atggcagcca cgtacgcttg 1256941 gggagcggga gcgggggtcg ttcattccgc tgcagccaaa gcgggggtat tgtcattgac 1257001 aagaacgctg gccgttgaat gggggagcaa atacggcatt cgtacaaacg cgatagcccc 1257061 cggaccgatt gaacgaacag gcggtgcgga gaagctattt gaatcggaaa aagcgatggc 1257121 ccgcacgatg aacagtgtgc cgctcggccg attgggcaca ccggaggaaa tcgccgcttt 1257181 ggcagcgttt ttgctttctg atgaagcatc ctatataaac ggggattgta tcacaatgga 1257241 cggggggcaa tggctgaatc cttatccgtt ttaatctgaa tatttataag tgaatattta 1257301 agttattaag aacttttatg ttcgaatgta atacctccac aattaacctt cttcctatcc 1257361 aatttgataa cacatagagc tttatttgtt tatgaggtgt tgtgtcatac gtaagccacc 1257421 taatatatga aaggtatatt ttaaaagggg agacgaaata tgaagaactt agatttcaaa 1257481 taaaacattc atataattac ttcgttaact aaaaagagaa attataagaa tgaaaggttt 1257541 caaggttaca tcagattggg aggaaggtaa tataatggac gagatggtat tattaactca 1257601 ggaatggctc aatgaaacgt acaaaggaaa aagtggctac aattccattg aggaaaatgg 1257661 gaaaactggc tggaaaacaa tgtatgcatt aactagagca ttacaactag aattgggaat 1257721 tacacagact tccgacagtt ttggtcctac aactttaaga aagcttaaag aattaggccc 1257781 gatttctacg tcaactaatt caaaaaaaaa tattgtgaaa attattcaag gtgctcttta 1257841 ttgtaaaggt tatggtccag gtggattaac gggtacattt ggtcagggaa cgaaagaggc 1257901 gatagcagaa atgcaattgc atatggggct ttctaaaaca gacggtgtag taacgcctaa 1257961 ggtgtttaaa gctttattaa acatggactc ttatatcctt ttaaatgggg cgtcagagaa 1258021 agttcgttca atacagcaat ggctaaataa taaatattac aatagagaga atttctactt 1258081 tatgccctgt gatggcctgt attcaaggga tactcaaaag tctcttgttt atgcaataca 1258141 gtacgaggaa gggttaagtg atagtatagc taatgggaat tttggaccaa ctactcaaag 1258201 attgattcct gtattaagaa ttggagaaac agatgaaaaa aacagtttta ttcatttatt 1258261 tcaagctgct ctaatcttta atggctacaa tgttcctttt gatggagtat actctgaatc 1258321 tgtaagatca aaagtaaagg cttttcagtc ttttgcaaaa ttacaacaga gtggtactgc 1258381 cgactttcaa acatgggctt cacttctagt aagtactgga gaccccaatc gaaaaggagt 1258441 tgcttgtgac tcaattactc aaattacatc ggacagggcg gagtccctta agagggcagg 1258501 ttataagatt gtagggcggt atctaacaaa tgcgccgggg agtacactaa ataaaaaaat 1258561 acaaccaggt gaattagaaa ctatcttaaa atcaggttta aatgtttttc cgatttatca 1258621 aacctatggg ggagcaacaa attattttaa taaagaacaa ggaaagaaag atgcgtttgc 1258681 tgcttataaa gcagcaaaag aatacgggtt taaaaataac actgtaatat actttgcagt 1258741 agattatgat gcatatggta acgatttaaa caacaatatt attccacact tcgaaggtat 1258801 aaatgaaata atgaacggtt ttttaggttc aacttacaaa attggtattt atgcccctag 1258861 gaatgtatgt actatagttt ctaaaaaagg tttagcattt gcaagttttg taagtggtat 1258921 gtctactggc tttagcggaa acttaggata tcctttgcct tacaattggg cgtttgacca 1258981 aatttcaaca attactgttg gaaatggttc tggaatgatt gaaattgata atgatatttg 1259041 ttcaggtttg gataatggag ttaataccat aaatatagtg ccttcagaga ataagaagtt 1259101 ttttgatcaa attgatgttt tatatgaaac tgctgaaaaa tatgctcaaa tgcaaagcga 1259161 cttaaataat ggggtaaaaa aaacacaatt agctaatgag ttggttgccc agtatttaag 1259221 aaaggatgac tacaaagggt ggaagtgggt ccctaccgca ggccagattg atcctattta 1259281 tcgtgaatgg gcagtaaagc gctaggggaa gacctagtaa atggaattgt tgatcctata 1259341 tcaaaaactg tcataggaac gcagcatctt atggcaactt ataatgccat tatttatagt 1259401 ggtggttact ctcaaacact acgagatttt gctggttgga ctggagatct attaacaaca 1259461 atacaggaca tgaaattaca cgctcaagaa tttaattcgc cttatgatgc ggctatgaaa 1259521 ataataggta atatgtatca atttagccta gatgatttat ttagtgatgt agatgcaatt 1259581 aatctagcga ataaaacatc agttggtgct aatgcacaac ctctaaatat cgcaattaga 1259641 gattattata gtaataatga ctgtatgaat aggttcactc aatttgtaaa taatagattt 1259701 gatggttcgt tagacaaaat tttctctgaa gcagagtatt atttaaatac aaaccttgac 1259761 ccagttgttg ttccaattag gttagccttt aaacgtgctt ttgatgttga ggattatagt 1259821 gaagagattg gaaaaataac agcacaagca tttagagatg ttatcgagaa aaaaatgata 1259881 tctgaataaa ctgcaaaaca agcgaacgtt aaaactggtc gttcgcttgt tttattttct 1259941 atttaaattt atgatataat ttttaaagat taaggagtga ttcattgaag aaattgttaa 1260001 aaaagttagt tgtattattt ttaagcagtt tagttatcat ctttaatgtt tggtacttta 1260061 ttatttgtgc tttttcccca gagtattatc aaaatacaaa tcttacttct aatgaaataa 1260121 taagatttga aaaactatac cacatagatt ttcctgatga aacaaaattt attaaagcta 1260181 gagagtattt ggctgggccc ggaggagata cgtcagctgt attatatgtg tctctgccaa 1260241 ccaagcgggt agaaaaagtt ttatctgatt acacgtatat gaaaataaac tatactgaca 1260301 atgtcggttc aatgtatgga gttgacgttt caaagagtgt cgccggttta acaactctta 1260361 catttggcac ttacgataaa aaaggaactt tctataatat gaaacatgat gatgattgga 1260421 tgtataaagg cactgactgg aatctttact tttggacagc tgctagttat aatgctgtta 1260481 tttttgtatt tgttttggtt attgtgaaac aaatgaataa aattcttaat taaccagtat 1260541 gtagattgat aatctcaaaa aaattttcct cttcttttaa catactccat acgacctact 1260601 tttccatact atgatttttt tgaaatttgt ggtgtagtta taattgtgcg tataatcaga 1260661 caaagataga gaagcaggtg ataacatgtt ggatccactt gatattttaa cgaacattga 1260721 tgatgtcctt ccatattacc aggcgatttt tagtgccgag gagcagaagg ttgtcggata 1260781 tgaggtgctt ggacgaattt tggcagattc agaaatccaa agtctcgggc ccttcttttt 1260841 agatgcgggg atacccgaag aatataaatt agaggttgat aacagaatta tccgccaggc 1260901 tcttgaccgc tttttagagg cggattctga tctgctgatt tttatgaatc aggatgccaa 1260961 tctgctgatg ctggatcatg gtgaaagctt tctggagctt ctgaaagaat atgaagcgaa 1261021 gggaatcgaa ctccaccgtt ttgtgcttga aattacagag cacaattttg aaggggatat 1261081 tgagcagctc taccatatgc ttgcatacta tcgtacatac ggaattaaaa tcgcagttga 1261141 caacatcgga aaagaaagca gcaacttgga cagaatcgcg ctgctctcac cagatctgtt 1261201 aaaaatcgat ttgcaggcgc tgaaagtgtc acagccgtca ccgtcatatg agcatgtgct 1261261 gtacagcata tctttattag caagaaaaat cggtgcggcg ctgctgtatg aagacattga 1261321 ggcgaacttc cagcttcagt acgcctggag aaacggaggc cgctattttc agggctatta 1261381 cttagtgtct ccatctgaaa cgtttctaga gagagatgta ttgaaacaaa gacttaaaac 1261441 tgaatttcac caatttatca cacatgagaa aaagaaactg gagaccgtct atgagcactc 1261501 tgaacagttt tacaaacgag tgcatcaggc tgtgacctct ttgagaaaaa acaatctgtc 1261561 ttctgatgat gactttatta aaaagctggc ggaagagctg acagattgca gcttcaggat 1261621 ttacatgtgt gatgaagaag gcgatcagct gacgggaaat gtgtttaagc aagatggaga 1261681 atggatttat cagccggaat atgcggaaaa gaactggagc tggcgccctt attttctgga 1261741 gaacattatg agaatgagaa atctcagaaa aggttttttc agtgatctgt acagtgattt 1261801 ggaaacaggt gaaatgatca gaacgttttc atatccgatg gatgatcaga tgtatttatt 1261861 tatagacttg ccttattctt atttatatga gcaggacgga ctgatttaac ggctgaaagg 1261921 ccgttttttt tatgaaatga aaaaaatatc aaaaaacgat tgacattgat actgagaatc 1261981 attatcattt aattatagag agaagctact ctctgttccc caacccctct atcagatcaa 1262041 gatccgaaaa aacttggcgc tacccccgcc aagtttttta tttgtcaaag cataggacaa 1262101 tccaatgaaa caataaacct aactagtggt aaacgtttaa cacggggaga aacattgagt 1262161 gccgaacacc cctgacactg ctgcacgggt gaggaggaaa attcgttctg aaatgattat 1262221 ttcagttccg ttgtttacct ctatccagca tgactcccat tgattatggc cacgcgggac 1262281 ttcaccataa aattcaaaag aaggttttga caaagttgca aaaaggcatt cttaatgctg 1262341 ccaaagattc gaaaaaaatt ataattatgt gcatgacatt caaaaaaagc ctcaaactaa 1262401 agaaaaatag tttttttcac tttttttctt tgcttaaatt cagcagtgaa aatgccatcc 1262461 tgtccgactt tatggtatga tgctcaatag aacttgtatt ataataaata cttgttgatt 1262521 tgaagttgct ttttgaaagg agtctttttt tagaatgtca caattaatgg gtatcatcac 1262581 acggctgcaa agtctgcaag aaacagcgga agcggctaac gagccaatgc agcgttattt 1262641 cgaagtgaat ggtgagaaaa tatgcagtgt taaatatttc gaaaaaaatc aaacgtttga 1262701 actgacggtt ttccaaaagg gtgaaaaacc taacacatat ccgtttgata atatcgacat 1262761 ggtttccatc gaaatctttg aacttcttca gtaagattcc tgaaataggg ggaacaagct 1262821 tccgcctttg caaaagtaat cgaaataaac ggtaaggaac atacttgttt catggttgta 1262881 aatccttgaa aaggagtgtc gtgatggctg attcttttct gttttataat ctttcagaag 1262941 cacagatgac ctttcaagat gtgatggaac ggcttaaagc ctttgttcaa aaggaccccc 1263001 gttcttctta tgtgttatcg atcggaaccg attcacaggt ttaccgcgat tacacaaagt 1263061 ttattaccgc attgcatttg catcgtacag gcaagggagc ttggggctgc ttgaaaaatc 1263121 atacagtcga cagacccata catagccttc gggagaagat ttcgttagaa acggcgtaca 1263181 gccaagaaac ggccgctcat attcttgatg gacacttaat ggatattacc gatctgctcc 1263241 tgccctttac cggtgagggg gcggatctta cctttgaagt tcacttggat attgggaaaa 1263301 aagggcttac aaaagatctg atccaagaaa tgactggacg tattacctcc atggggattg 1263361 aggccaaaat aaagccggat tcatacactg ccttcagcta tgcaaatcgt ttcacaaaat 1263421 aatttggctg aaaaagccaa ggtaaatgtc gaattatgcg gttgacgttt gttatctgat 1263481 tacttattct agcggtagag ctgaaagtaa gttgtcttgc tttcagaggt attcagtata 1263541 aaacaggggg cctgattgcg aatgagtctt atcggtgaac gatttacaga agaagaacaa 1263601 aaacttctgc tgaatatcct gatcaaccat gagtatgcca tcgagctatt aagcagtgag 1263661 atcaacgata tagagacagg gaccaaaaac gttgacggaa ccacctacaa aaaacttgta 1263721 acgctatacg accgatttcg atttgaaaat taatgggaca ccctataatt gatactccac 1263781 aaagagtatc ttttttattg aaaggaaact tttcgacaaa tactgataaa gtttatatta 1263841 ttgcaatata gggaatgtat tgatgatgaa aatgaaaagg ggtcgaaaac atgataagct 1263901 tacaatcaga tcaacttctt gaggcaacag tcggacaatt tatgattgag gcggacaaag 1263961 tagcgcacgt gcaagtcgga aataaccttg agcatgcatt attagtattg acaaaaaccg 1264021 gatacacagc catcccggtt ctggatcctt cctaccgttt acatggctta atcgggacaa 1264081 atatgatcat gaacagtatt tttggacttg agcgaattga gtttgaaaag cttgaccaaa 1264141 tcactgttga ggaagtcatg ctgaccgaca ttccgcgcct tcatatcaat gatccgatta 1264201 tgaagggatt cggcatggtc attaataacg gatttgtctg tgttgaaaat gacgagcagg 1264261 tatttgaagg gatttttacg agaagagtcg ttttaaagga attgaataag catatacgct 1264321 cattgaataa gtaggctgta cggtcctatt tttattatat aggcagagtg aaaaaagaaa 1264381 gcgcatacat aatttaaacg agaatagggc ttgaataaga aactaagatt ttattagaat 1264441 gggagataag aaaaacttat tgataacaaa aaggaggacg acatgcagct tcaagagctt 1264501 catatgctcg tagttttagc tgaggaatta aatatgagaa aggcggcaga acggcttttt 1264561 gtatctcagc cggctttatc tcagcgctta caaaccattg aaaaggcgtg gggaacaaaa 1264621 atctttttaa gatctcaaaa aggattaacg gtaacgcccg ccggtgagaa aatcattcag 1264681 tttgcgaatg atgtgacatt agagcaggaa agaataagag aaaatattga cgagcttgaa 1264741 ggtgaaattc acggcacatt gaagcttgcc gtcgcctcca taatcggtca gcattggctc 1264801 cctaaagtcc tgaagacgta tgtggaaaag tatccgaatg caaagatctc gctcataacc 1264861 gggtggagca gcgaaatgct gaaaagcttg tatgaggatc aggttcatat cggcattata 1264921 agaggcaacc ctgagtggaa ggggcgcaaa gattacttaa tgacagatca tctgtattta 1264981 gtggatactg aaatttcctg catcgaagat attgcccata cagaacgtcc gtttatccag 1265041 tttaaaagtg acagcactta ttttcaggaa attcagcact ggtggcatca aaaatttaaa 1265101 acgtcgccga aacagacgat attggttgat cagattgaaa cgtgcaaaca gatggcgctg 1265161 cacggaatcg gttatgccat tttgccgtct gttacccttc aaaatgaaga taaagtgaat 1265221 aaaatgcctc ttttagacat gaaagggcat ccgatcggtc gggatacatg gttattaggt 1265281 tatgagcctg cctttgaact gaaacaagtt caagcttttg tacaagtgat aaaggatatg 1265341 ctggatcagg aaaatccatt ttaaagacag cgaggtgctg tctttttttt atttatctgt 1265401 tgacaatgaa aatcattatc atttaaagtg atacatatga tattgaaaat cattatcaac 1265461 taatggggtg ataacatggc taaagccttg attacatatg ccagcatgtc aggaaataca 1265521 gaagacattg ccttcataat aaaagatacg cttcaggaat atgagttgga tatcgattgt 1265581 gtcgagataa atgatatgga tgcgtcttgt ttaacctcct atgattatgt actgattggc 1265641 acctatacat ggggggacgg cgatttgccc tacgaagcgg aggatttttt cgaagaggtc 1265701 aaacagattc agcttaatgg tttaaaaaca gcctgcttcg ggtctggcga ttattcttat 1265761 ccaaagtttt gcgaagcggt gaatttgttc aatgtcatgc tgcaagaggc gggagctgct 1265821 gtttaccagg aaacactaaa aattgaatta gcgcctgaaa cagatgaaga tgtggaaagc 1265881 tgccgagcgt ttgcgagagg ttttcttgca tgggcagatt atatgaacaa ggaaaaaatc 1265941 catgtttcat aaaggggcaa ccgctgttac ggcatcggcg ttttctggat attttgtggc 1266001 ggtacaaaga gaaggcattt ttcattactc tttggagcag ggctggagaa agctttttcg 1266061 tttgaaaagt aagatacact gtatcagcta catagggcct tacttatttg gcgttggtga 1266121 aaagggaaca gtcattcgtt cggctgatga agggaaaacc tggacgatgt cgagctttcc 1266181 gacaaatgca acagtgtggg cgattaccgg cagaaacaac gggtttgtct gcgcccacgg 1266241 taagcattgt atttatgtat cggatgattt tggtgtctca tggcgcgtag ccaaaccttt 1266301 tgccgaattt cataatcccc ctgttatccg gtcgttatgc cttcacgggg gcaatctctt 1266361 tatcggcacg caaatacacg aatattttgg cggcatttgg gcttacgaca ttaagcgtga 1266421 cactgtccaa gttgtcaaaa aagaaaaaaa ccggatgacg gcatccatgc tcgtgttcaa 1266481 tgaaaattgg ctggtggcgg cgatgggttc tgtgaaagga aagcacggtg ctgtcactgt 1266541 aaggaatctt ttgaatggtg aagaattcac catacaatcc agtatgatca gaaatgaaga 1266601 atcatttctt gatctttcag aggatgatgg cattatatat gtcactacaa cacaagatga 1266661 aaatggtttt tcgagaattt accaggttga tctcgaagcc cggtcgttaa aatggttcga 1266721 taccattaag ggacatggat ggagagtggc caatcagaaa gagaatttct tttgcgcagg 1266781 cttgtatgaa tgtaaatttg tccagccgta cgaagtttca gcaatgattc attagaggag 1266841 gaacaaggaa ttggcgaaga ttttgctcgt ttatgcaaca atgtcaggca acactgaagc 1266901 tatggcagat ttgattgaaa aggggcttca ggaggcgtta gcagaagtag accgtttcga 1266961 agcaatggat attgatgatg cccagctgtt taccgattat gaccatgtca taatgggaac 1267021 ctacacgtgg ggagacggag atctgcctga tgaattttta gatcttgttg aagacatgga 1267081 ggagattgat ttttccggca aaacatgcgc tgtattcggt tccggtgata cagcatatga 1267141 atttttctgc ggagcggttg atacgctaga ggcaaaaata aaagaacgcg gtggagacat 1267201 tgtgctgcct tcggtaaaaa tcgaaaataa tccagaaggt gaagaagagg aagaattaat 1267261 aaacttcggg agacaattcg caaagaaaag cgggtgcgct gtctgatcac tcactgggaa 1267321 ctgctaaaac ggctgttcct ttttttcttg tctttgtatc tttcctttga tacagtaatg 1267381 aggtagaaaa tcaggaggag gactatacat atgaaaatga tggacgcaaa tgaaattatt 1267441 tcatttattc aaaatagtac aaaatctaca cctgtaaagg tttacgtgaa aggtgagctg 1267501 gaaggaatca atttcggtga atctgcgaaa gcttttatca atggaaacac tggtgtcgtt 1267561 ttcggtgaat ggagcgaaat ccaaacagca atcgaagaaa accaaagcaa aatcgaagac 1267621 tatgtggttg aaaatgaccg ccgcaattct gcgatcccaa tgcttgatct taaaaacatc 1267681 aaagcgcgta tcgagccggg tgcgatcatc cgcgaccaag ttgaaatcgg tgataacgca 1267741 gtcatcatga tgggtgcttc tattaatatc ggttcagtca tcggcgaagg cacaatgatt 1267801 gatatgaacg ttgtgcttgg cggacgagct actgttggaa aaaactgcca tatcggcgcg 1267861 ggttctgtac ttgcgggcgt tattgagccg ccatccgcta aaccggttgt gattgaagac 1267921 gacgtcgtaa tcggcgcaaa tgctgttgtg cttgaaggtg taacagtagg taaaggagct 1267981 gttgttgctg cgggagcgat cgtggtaaac gacgttgagc catacactgt cgttgcaggc 1268041 acaccagcta aaaaaatcaa agacattgat gaaaaaacaa aaggcaaaac tgaaatcaag 1268101 caggaattac gccagctgta aggaaaagtt tgataaaaaa ggcgtggata atatatccac 1268161 gccttattcg tataggcagg aggaatagaa atgaagatag aggagctcat cgcaattcgc 1268221 agagatctgc atcgtatacc ggagcttgga tttcaggagt tcaaaaccca gcagtattta 1268281 ttaaatgtct tggaacaata tccgcaagac agaattgaaa ttgagaaatg gcgaacaggg 1268341 ctttttgtaa aagtgaacgg gacggcgccg gaaaaaatgc tggcatacag agcggatatc 1268401 gatgcgcttt ctatagaaga gcaaactggt cttccattcg catcagagca tcacggcaac 1268461 atgcacgcct gcggtcacga tttgcatatg acaattgcac tcggcattat tgatcatttt 1268521 gttcaccacc cagtcaaaca tgatttgctt tttctgtttc agccggcaga ggaagggcct 1268581 ggcggtgcgg aaccaatgct tgagagcgat gtattaaaaa aatggcagcc tgatttcatc 1268641 actgcccttc atattgctcc agagcttccg gtaggcacca ttgcgacaaa aagcggcctt 1268701 ctatttgcga atacatcaga gctagtcatc gatctggaag gcaaaggggg acatgcggca 1268761 tatccgcatt tggctgagga tatggttgta gcagcaagta cacttgtcac ccagctgcaa 1268821 acgattatct ctagaaacac agatccgcta gacagtgctg ttattacagt tggtaccatt 1268881 accggaggct cggcacaaaa tatcattgca gaaacggccc acctggaagg cacgatccgc 1268941 acgctttctg aagaatcgat gaaacaagta aaggaacgga ttgaagatgt agtgaaagga 1269001 atcgaaatcg gattccgctg caaaggaaaa gtgacatatc cgtctgtata tcaccaagtt 1269061 tacaatacga gcggattaac agaagaattt atgtcttttg ttgctgaaca tcaactggcg 1269121 acagtaattg aagcaaaaga agcaatgact ggagaggatt ttggctatat gctgaaaaaa 1269181 tatcccggat tcatgttctg gctcggcgct gattctgaac atgggcttca tcatgctaag 1269241 ctgaatcccg atgaaaatgc gatagaaaca gcggttcatg tcatgacagg ttatttttct 1269301 gtttatgcca attaagtaca aatgaaagaa taaaattcca taaaatgagc actctagtaa 1269361 acggaggtgt tcaaaaatgg ctaaaaaaat tggaattgaa caatcgttat cagatgtaga 1269421 agctgcttta aaagaaaaag gatatgacgt tgtaatgatg aaaagccctg ctgatgctca 1269481 aggctgtgac tgctgtgtcg taacaggtct tgataataat gtgcaaggga tagccgatac 1269541 ggtaacacaa gcacctgtca ttacagcttc cgggatgacg gctgaagaaa tttgtagcga 1269601 agttgagagc agaattcagt aataaaaaaa ccgaagcaaa aagcttcggt tcttttattt 1269661 attctgtttc tttagggaaa gcgcggtcga acgcgttctt tatttctttt ctcaacactc 1269721 gttcgactcg ccactgttcc atattttctg ttttggcaat gaccctgatt acaatttcag 1269781 aagtccccag ttcttgaatc ccgatgacat ttgggccttc ttttatttgt ggaagagccg 1269841 ctgccgtttc atcacaaacc tgctgtaaaa tatgaatcat ttcatcaata tttctttcag 1269901 ccggcacttt aatgtcaaca agagcctgca tggtaccacg agaatgattg ctcacgtttg 1269961 tgatgtttct gttggggatg taatgcagtg ttccgtcaaa gctgcggatt tgagttgtcc 1270021 ttaagccaac ctgctcgaca attccgtcaa aggtggaaac ggtaatataa tctccgacat 1270081 ccaattgttt ctcaagcaaa ataaaaaaac ctgtcacgat atcactgaca agcccttggg 1270141 cgccaaatcc gacagccagg ccgacgattc ctgcccccgc taaaagagcg cttggatcat 1270201 aatgaaacaa atctagaacc atgacgaaaa atatgaaaat caatgtataa gcaaatatgt 1270261 taagagtcag gcttcggagc gtatgtgcac gtccgataga caagctattc tgctcctcga 1270321 attttgcaaa cagatgttta atgattttca tgcctaatga tcgaacgata aaatagagca 1270381 atatcataat ggcgagttta atgagcagaa caccggcatt tgtaatcagt cccgcccaat 1270441 catattgttt aataaagtcc atgttgagct ccttttctaa ttgattgctg cacattgaga 1270501 ctagttaccc tgtacatgac catgttaaac gttttattca aaaatgtcga agccaaagac 1270561 atacatgatt tgttaaaaat tgactcagga aatctgcttt tatataatgg cattgcaata 1270621 taactaaaaa tggttaatca ccctttattt tcatgcgatt ttgaccttta agccaaacaa 1270681 taaattggag ggatacatat ggcagaacgt atggtaggta aacaagctcc tcgttttgaa 1270741 atggaagcag tccttgcaag caaagaattc ggcaaagtaa gtcttgagga aaacatgaaa 1270801 aacgacaaat ggacagtgct gttcttctat ccaatggact tcacttttgt ttgtccgaca 1270861 gaaattacag caatgtctga ccgctatgac gagttcgaag atcttgatgc agaagtcatc 1270921 ggggtttcaa ctgataccat ccatactcat ttagcttgga tcaatacaga ccgcaaagaa 1270981 aacggtcttg gccagctgaa atacccgctt gctgctgata caaaccatga ggtatcccgg 1271041 gaatatggcg ttttaatcga agaagaaggt gtggctttgc gcggattgtt tattattaat 1271101 cctgaagggg agcttcaata tcaaactgtt ttccataaca acattgggcg tgatgttgat 1271161 gaaacgcttc gtgttctcca ggcgctgcaa actggcggac tctgtccggc taactggaaa 1271221 ccaggccaaa aaacacttta attctttcca agaacgaaaa gcggtctagc atattcgtta 1271281 ggcctctctt ttaaaatagg agggaaaaag caatgaaatt acgtcagccc atgccggaat 1271341 tgacgggaga aaaagcttgg ttaaatggtg aagtgacgag agagcaattg attggggaaa 1271401 agccgacgct tattcatttc tggtccatca gctgccactt gtgcaaagaa gcgatgccgc 1271461 aagtgaatga atttcgtgat aaatatcaag atcagctgaa tgttgtagct gtacacatgc 1271521 cccgttccga agatgatctt gaccctggta aaattaaaga aacagctgct gaacacgata 1271581 tcactcagcc gatttttgtt gacagtgacc atgctttaac cgatgcattt gaaaatgaat 1271641 atgtacctgc atattatgtg tttgataaaa caggacagct ccgtcacttc caagccggcg 1271701 ggagcggtat gaaaatgctt gaaaaacgtg tgaaccgcgt tctggctgaa acggaatagg 1271761 tatctgacta aatagtattt cctaaaaacc tgacctcatc aggtttttta tttgtgcaaa 1271821 aagcaatgga agaagagtaa gaagcttatt tttccaaatt tgggtatagg aattgatgat 1271881 ttgtttgatt gatacgctaa aaaacacagc taatttttga tgtttttcct caattttaga 1271941 taaatctcat atctcataac tcgaaaattg tagatattac actaaatttc tttaaagaag 1272001 taagtaaaat atatattttc aacattatac caaataaact agaaagcccc ttaatccctt 1272061 gagaataaag gactcttttg aaaaataaaa cattttcaga aaataaggaa tttttcatag 1272121 agtaaatata atagtaaaat gctaaaataa tagttgataa aattactttt gtaatctaat 1272181 atcttaatta aagatgttaa ttttgatagg gggtacattg aggaatgttt aatgaaagag 1272241 aagctttgcg cttgcggtta gaacaattaa atgaagctga agtgaaagtc attcgtgaat 1272301 atcaaattga acgtgataaa atatacgcaa aattaagaga gctggacaga aatggaagcc 1272361 cttccgaaat caaaaaggat ttccgttctg aaaaaaaacc tgactctctg ccggttctcg 1272421 ctgagcttgc ggctcaggaa atcagaagct atcagccgca atcacagcag cagtctgttc 1272481 agcctcagct tcaatctatt tcctctcttc ctgccggtat accagacgga acaacacgaa 1272541 gaagaagagg aacggcaaga ccgggatcaa aagcagctaa gctgcgtgaa gctgctatta 1272601 aaacattaaa acgccacaac gcggcgatta agagctcgga gcttcaaaaa gagattgaaa 1272661 aagaaagcgg tcttgaaatc cctaatatga caacgtttat gcaaagctta attaaaatgt 1272721 acccggaagt gaaaaagcca tatcgcgggc agtacatttt agagggtgaa atcgaatctg 1272781 cagaatcagc aaacgaataa atataaagaa aaactgcttg gcatcgctca agcagttttt 1272841 ttattgaggt tttttctgtg aaggtttgtt ttctttttca agattaagct tatacaccca 1272901 cttttgataa ggcttttctt cagcggctct gtttttcagc tcttcgattg tatggctctt 1272961 ggcctggtct gatgattggg cgtgggcaag ctgtttttga agcacatgta tctgtttggt 1273021 gacatcttca aggatagtct ctacatgatt tggctgcgcg taggccgctg gagcttcttc 1273081 ttccgttttt tctttttgtt tcgtgccgcc atcaatatcg gcaaaatgag aagcaatcca 1273141 ggcatcgctt tcatcaagtt gccgtttata cgatataata gtttcgtgaa ataatttttc 1273201 tttcgttttt tctatgtcta gcagtctttc tttcgtttct atgattcgat ctttcatatg 1273261 atcaacttct attttaatat gttttagctg atattctttt tctaccattt gctcttttag 1273321 acgcccgttt tcggctttta tcaattcggc ttgctgtttt gcctgaagca gtgcattttg 1273381 ttcctgctca attgaggctt gaagttcgct gatccgttta tgaagatttt tattttcttc 1273441 ttcgattttg actttcgcaa tatgaagttt atgtttttct tcgatttcgg ctctgcgttt 1273501 ataggtttca gcagatagaa gctcctgcaa aacaacgatt ttatcaagca gttcagctct 1273561 tatttggtgc agggtttggc tggtgtggga ggcatgtttt tcttttgttg acatatgtgt 1273621 taattcggca gacagctgct ggagtttttc tttcatatcg gtattttctt tgagcagttt 1273681 gttatttttc tgatgaaagt agcttgcttc aagttcagaa atcagcttat ggcaccttga 1273741 aagctcggat tttaaataaa ggttctcctg agacacgtcg tggaaaaaag gacctgatct 1273801 tttcattcga accatctccc tcatgatgtt aacactacaa tatgcaaata ctgaacagct 1273861 attcctcttt aataaacaga caagcagtag cgttgagcct ttgcttttgc tatgctttta 1273921 acgaaactag aggtgagatg atatgaagca tgtaaacgta ctgctggcag ggggagcctc 1273981 acgtcgcttt ggagaaccga aggcgtttgt caaatggaag ggcaggatgc tttacgaatg 1274041 cgctaaagag gcacttggag aacaaacggt tatcatcagc cgtcccgaat ttattgatag 1274101 atttcaagaa aacggtgaaa atgaagtgta tcaagatgct gagccatttc aaggcatggg 1274161 gccattggct ggtatatata ccgcttttaa aaagacagac ggtgatcttt atactgttct 1274221 ttcctgtgac acaccgctga tacaaagaag gacgatgctg gagctcaaac gtctgatgat 1274281 tgccggtgcg gacgcggtag tcccaatttc agacggacaa gtgcagccat tgattgcgat 1274341 ttaccacaaa cgtatcatgc cagttctata cgatcagctt tctgagaaga ggttgagaat 1274401 atcagattta ttaggcagaa tttcggtttg ttacgtacag gctgaaaata tcggagcaaa 1274461 cccggcagag tttatcaaca ttaatacacg tgatgatttt agctgtttgg aagaaaaatc 1274521 gaactccctc aagcgggact gacggggcaa taacatgata agatgacata aaagataagg 1274581 agaacaggtt tgatggagga acgttattca cggcaaatca gatttaagca aattggggaa 1274641 gagggccaga aaagactggc agacagccat gtgctgattg tcggagcggg agcgctcggc 1274701 actgcaggag ctgaagggct ttcgagagcg ggagtcggta cgattaccat tattgaccgt 1274761 gactatgtgg agtggagcaa tcttcaaagg cagcagcttt atacagaaag cgatgccaaa 1274821 ctccgcatgc cgaaagccat ggctgccaaa gagcatctat cagcgattaa cagcgagata 1274881 catattgagg cgtatgttac cgaaggaaca gccgaaacgc ttgagccgct gattgaaaaa 1274941 gcagatgtcg tgatcgacgc gacagataat tttgaaaccc gcatgctgat aaacgatctt 1275001 gcccagaaaa caaagacacc ttgggtctat ggcgcctgtg taagcagcca gggaatgttc 1275061 atgactgtca ttcccggaga aaccccttgt ctgtcttgtt tgtttgagca aattcctgtc 1275121 ggcggggcga cgtgtgatac tgccggcatt attccgcctg ctgtgcatat cgtttcagca 1275181 tatcagcagg ctgaggcatt aaagctgtta accggccaaa aagaagcaat acagcggggg 1275241 tttgtgacat ttgatgtctg gaacaattcg catatgaaga ttaacgttaa tcatgtacgc 1275301 cgtgaggaat gcccatcttg cggagctaat gcggtatatc cttatcttca ggattggaac 1275361 acaccaaaag ctgctgtact atgcggccgt gatacagtgc aggtaaggtc agaatcatta 1275421 aaaagaatcc cgaaacagga gctcattaag cggctgaaaa caatcggcaa ggtcgaggct 1275481 aatgcgtttt tgctgcatat tttttacgag gatttcagaa ttgtcatttt caatgacgga 1275541 cgggcactgg tgcatggaac aaatgatgtg aaagaagcca actccgtgtt ggcaagagtg 1275601 attggactgt aacaacagga ggggtcagaa tgctggagaa aagaacaccg ataccggtag 1275661 acgaggcagt tcggcgtgtc tgccattttc aaaaacaagg tgaaacagaa tgggtggcgc 1275721 ttgaagacag ccttcatcgg tttttagccg aagatataac tgcggatcac cacgtacctg 1275781 cgtttgaccg ttcgccatac gatggttttg ctgtcagagc gtgcgatacg gcagaagctt 1275841 cacgtgaaaa cccagttcgg tttgaagtta ttgaccatat tggagcggga gcagtatctg 1275901 aaaaagaact tggcccgttt caggccgtgc ggattatgac tggcgcgcaa atccctgaag 1275961 gggcagatgc agtcgtcatg attgaactga ctcaagcctt tgaggagaat gggaagtcat 1276021 ttatgtcttt aaaacgccgc tttcagacgg gggataatat ttcaaaaaca ggtgaggacg 1276081 ctcaaaaagg gagtgtttta ctgacaaagg gcacccgggt gacaccagga gtgacggctc 1276141 ttttggcaac attcggatac gcatctgtgc ctgtcgtgag aaagcctgta gtcgggatta 1276201 tcgcaaccgg taccgaattg ctgaatgtca gtgatccgct ggaaccggga aaaatccgca 1276261 acagcaatgc gagtatggta tatgcgcaag cgatagaagc aggcgcaaca ccgctttatt 1276321 tagggaaaat ctctgatgaa ctggataaaa gctttgctgc agttaaagaa gcgatgaaaa 1276381 aggtggactt cctgatcaca actggcggtg tgtcagtcgg tgactttgac tttttgcctg 1276441 cgatctatga aaaactcgga gcggacgtgc tgtttaataa agttgccatg cgcccgggca 1276501 gcgtgacaac ggtggcgcat gcaaacgata tgctgctgtt tggcctttca ggtaatccgt 1276561 cggcatgcta tgtcggtttt gaactgtttg tcaaaccgat aatccagaca tggctgctca 1276621 atgaaacacc gcattcaatt tgtgcggaag ctgttttgac caaggatttt ccgaagccga 1276681 acccatttac ccgatttgtt cgtgcgctcg tgcaccatca ggaagggaag ctgttggcga 1276741 cacccgttgg cttagataag tcgagctctg tcacatcact tgcagatgcc aatgcattta 1276801 ttatcctgcc gggcggtacg cgaggctacg aatctggcag aacggttcaa gtgctgctca 1276861 tcagagaaga gaatggaagt gaatggcctt ggtccgtcct ttcccgatcg tccaagttgt 1276921 aggatttcaa aacagcggga aaacaacgtt tattgagcgc attcttgaaa aagcctctga 1276981 acagggagtc catttgggct gcctgaagca ccatggtcac ggcggtgaac cgcaaacgct 1277041 cacggaagga aaagacacgg accgttacaa ggcggcaggt gctgatgtaa cagcggtaga 1277101 aggtgctggt gtgttacagc tgactgcccg ccgcaattgg gatttggcac ggctgattga 1277161 gttataccaa tttctcgaaa cagactgtct tctgattgaa ggctttaaaa aagcccctta 1277221 tcctaaagtg gttatcctaa gtgaaaagga agatctggaa gcgctgcaag cagtaaatat 1277281 aatcgccatc atctatagaa aaaaagagca tatgacagag catcagggat tacccgtttt 1277341 tcatgcggat gatccggttg ccgtggattt tgtgctttca cagctgaagg gggaatctgc 1277401 ataatggaac ggtttgagat tacgaaaaca cccattaata ctgaaaacat catcaaaaaa 1277461 gtggagaaac gggaagcggg agccattaca acatttattg gtacggttcg ggaatggaca 1277521 aacggaaaaa gaacggttcg gcttgaatat gaggcatatg aaccgatggc cgtgcaaatg 1277581 cttgctcaaa tcggcgctga aatcgaagaa aaatgggaag gtgcctcagc tgcgatcacg 1277641 caccgtatag gtgtgctcga tatcggtgaa gcagcggtag tgattgctgt atcttctccc 1277701 catcgaaaag ccgcatatga agccaatgag tatgcgattg aacgcattaa acagattgtg 1277761 ccgatttgga aaaaagaaat ttgggaagac ggtgagcaat ggatcggcga ccagctagaa 1277821 acgacagctt atccgaacgg aaaaccagac ctaagcgagg gagagcagca tgattaaaat 1277881 tcttttattt gcagggcttg ctgaacaggc cggtacacaa gcaatagaaa tagatatgga 1277941 acaagcaacc acagatgaaa taaaagcgag tctaaaagaa caatacggtc ttgaatctat 1278001 tgatacggct atgattgccg ttaacgaaag ctatgtaaaa gaaaatacct ctgtatcttc 1278061 gggtgacacg gtagccatca taccgccggt cagcggggga tgaaaaccgg acggcatttc 1278121 agccgtccgg tttttctgta tttcattggc atatccccaa gtatcctcag catacaatga 1278181 ttttctgtaa gcgtttattc tacatatgtt actccctata aagtaagaga ctcactccat 1278241 aattagactg aaattttgaa aaataataga aatttatttc gggtatcgat atagtgaaga 1278301 tgataaatgt tggaaaggtg ctggatatgg agacatttaa aagattaaaa atgtattatt 1278361 ggccgtacag aaaagtgttt atgtggtcgc ttctagccat gcttttgatg actgcaatta 1278421 ctgtcgttta tccgattatc ctgcaaatta cgattgatga gatcgtactg ggacggcagt 1278481 atcagcttgc ggcgtgggtc agcttaggat ttattgcggt gatggttttg aaaggaatgg 1278541 ctaccttttt tcatcagtat ttaggtgata tgttcgggat caaatccgtt tatcggctga 1278601 gaaatggtct gtatgaaaaa ctgcagcggc tttctttttc ttactatgat aacgcgaaaa 1278661 caggagattt gatgtccagg ctgactgctg atgttgaagg gcttcgtttt ttcttatcat 1278721 acggtctcgc tgagctcatt cgcttcggcc tgctggtagc catcagcctg tcggttatgt 1278781 tttactattc tgttcctctc acgcttgtga caatagctgt tctgccattt ctcgcggttg 1278841 cggtataccg gtttgacaaa agagtccatc ccgccttcag aggcatccgc aaatcgtttg 1278901 cgaaactcaa tacaaaagtt caggaaaata tcagcggcat taatacggtt aaatctcttt 1278961 ccagggaaga ttttcagatc agcactttca ataaagccaa tgcagaatac agggcgcagt 1279021 atttacaaac atcatccatt tggtctgcgt atttcccttt aatggagttc attggtaaca 1279081 cttgtattgt agctcttctc tcatacggcg gttacttggt tatgcaaaat cagctcaatc 1279141 ccggcgagct tgttgctttc ttcagccttg tcaattatat gatgtggccc attatgaact 1279201 taggttttgt catcaatatg ttctctcaag caaaagcgtc aggggaacgc ctgctcgaca 1279261 ttctggaaaa agaagaagac attacagatc atcctcatgc tttgcataaa caaaaattaa 1279321 ccggagatgt ccatttcaaa aatgtttctc ttgcatacgg aaaagaacaa acaaacgcgc 1279381 tgtgcaatgt aagctttgag gcaaacagcg ggaaggtaat cggactgttg ggcccgacag 1279441 gttcaggcaa aagctcagtg acacagcttc tcaccagatt ttacagtcct gttggcggaa 1279501 tgattaccat tgatcacaaa cccatcacag attattcgtt aaaaaccctt cgctccaata 1279561 tcggggtcgt acttcaagaa tccttcctgt tttcatctac gattagatca aatatttcgt 1279621 atgggcggcc ggatgcctca atggaagacg tcatcgaagc ggcaaaaagg gcgcaggctc 1279681 ataactttat tatggagctt cctgatgggt atgacaccat gctgggagag aggggaatgg 1279741 ggctttccgg cgggcagaaa cagcgtattg ccattgcgag agccatctgc ttgaacccga 1279801 gcattttaat attggatgat gccacaagcg cagtagatat gcaaacggag cacagcatac 1279861 agcttgcctt aaaagaagtc atgaaaaacc gcacaacctt tatcgtcgct caccgcattt 1279921 cttcactgaa acacgctgat gaaattctcg tttttaataa aggacgcatt cgtgaaaggg 1279981 gaacacatca tgagcttctt gaaaaaggcg gctactataa aaagatttac gatttgcaat 1280041 accgtgatgt caaaatgatt aatgagccgc atgaggtcgg atagggaggg gccaaatgaa 1280101 acaagcgaaa aaacaggggg ttttagagcg tttctattac tcttcagatg aaatcattga 1280161 aaagccgttt aactgggctc aaatgtggcg gctgctgagc tatgtcaaac catatcgaaa 1280221 aacaattttg ccgctttctt ttctcactgt attgattggc actgctgtga agcttgtgat 1280281 ccccattttg atcggcgttt atgttcttga tcaagcgatt acagggagaa actcggagct 1280341 gctgattcag ctcattttta ttattagcgg tttatatgtc ctcaattacg ccgccaatgt 1280401 gttaagaatc aggtggatga atcagcttgg ccagcatgtc atttacgatt tgcgacagca 1280461 tttatttacc catgtgcagc gcttatccca tcgatttttt gatcagcggt cggcgggatc 1280521 gatcttagtc aggatcatga atgatattaa ctctcttcag gagctcttta caagcggagt 1280581 catcaatttg ttgaccgact tgctgcttct ggccggcgtg attattattt tgtttacgct 1280641 gagccctgag ctgactatag ccatcatggt gacattgccg attatgtttt ttatttcaac 1280701 aagtctcaga aaaaaaatac gccgatcctg gcaaacggta cggctgaagc aatcgaagct 1280761 caactctcat ctaaacgaaa gcattcaggg catccgggtc acgcaggcat ttacgcagga 1280821 agaagaaaac atggcgtatt ttgacggtgt caatcaggag aactacgaat catggcggga 1280881 agcaactaga aaaaatgcca tgttccgtcc gcttgtagaa atgacgaatg cgattgggac 1280941 ggctgtcttg atttggtatg gagccacact catcatgaat gaaaccatta cgattggcgt 1281001 cttcgtttct tttgctttct atctgggaat gttttgggaa cctatttcga gactgggtca 1281061 ggtctataat cagctgttaa tggggatggc atcatcagaa cggatttttg agtttctgga 1281121 cgaacagcca aatgtcaagg agaagccgaa tgccattcat aatgaaaaga taaatgggga 1281181 gatcagtttt gaagaggttg aattttcgta tgatgaaaaa cgaaaagccc ttcacgccgt 1281241 ttctttctct attcctgcgg gatcgacgct tgcgcttgtc gggcatacag ggagcgggaa 1281301 gacgacgatt gccaatttaa tcagccgttt ttatgatgcg gccggaggca ccattaaaat 1281361 agacggtata ccgattaagg atctttccct tgccagtctg cgctctcaaa tcagcattgt 1281421 cctgcaagat acatttattt tctccgggac catcatggaa aatattcgtt ttggaaggcc 1281481 aaatgcttcg gatgaagagg tgatgaaagc gtcccaagcg gtcggagcgg atgagtttat 1281541 ttccgattta gcggaaggat acgcaacaga ggtagaggaa aggggcagcg tactgtctgc 1281601 cggtcagcgc cagctcattt catttgcaag agcattgctc gccgatccgg ctattatcat 1281661 ccttgacgaa gcaacggcaa gcattgatac agagacagaa gtaaaaattc agcaagcgtt 1281721 aaaaacgctt ctgaaagggc gtacagcagt gatgatcgct cacagattgt ctacgatccg 1281781 cgacgccgac cgcatcattg ttcttgatca cggcaggaaa atagaagaag ggaaccatga 1281841 tcagctgctc gctaaaggag gcatttatgc cgggcttgtg aaagcgcaat acagcacagc 1281901 gatagaataa tatgaaaagc cttcaatatt gaaggttttt ggaaatttat tagaaaaaca 1281961 tgaaactttt tgatatcctt cccgtactat ttgttagata ttctcaagga ggttttgaaa 1282021 tggaaacgaa tgtagaaaaa aacagcggaa cggcgactga aaagccttca cttttcggag 1282081 taatcacaag tccgtccgtt caatttgaaa gaataagaga aaggccggct gtatggggac 1282141 cgcttttgat tgttgcagca attatcatcg tcggtgccgt gctgcaatca ctcggtacgg 1282201 attatagtga gcttttgaaa agccaggata cgcaagggct atctgctgaa caaatggaaa 1282261 ctgtcgcaac aataaccaaa tttggcggaa tggcaggcgc tattatcggc ggtatcgcag 1282321 cattatttat tgcccctctt atttattggc tctgtgtaaa agtatcaggc ggtgttacga 1282381 catataaaaa aatgctttct ctcagtctgt ttgtctcttt gattagcagt ctcggattat 1282441 tggttaatgg aatcgttgct tttacgactg acgtgaatcc tctttacagc acgacgtcac 1282501 tcgcagggat tatcccatct gacggggctc tcgccagtgt gttaaatacc tttgaaattt 1282561 tcagcatctg gagctttgta ttattagcaa tcggacttca caaaacggga ggcatctcaa 1282621 aaaaagccgg gtggatttca gcaatcattc tattcggaat tttagttgta ttttcgcttt 1282681 tttcaggttt aatcaattct gtggcgggtg cataagctca tgaaaaaagt ctggatcgga 1282741 attggaatcg cagttatagt cgctcttttt gttggaatca atatataccg gtctgccgct 1282801 ccgacaagcg gcagcgccgg caaggaggta cagacgggga gcgttgaaga aaatgaaatc 1282861 tcatcaacgg ttatggttcc tggcacgcta aaattttcaa atgaacagta tgtcttttat 1282921 gaagcggata aagggacatt agaagacatt aaagtaaagg aaggcgataa agttaaaaag 1282981 ggcacggctt tagtcaccta tacaaatgag cagctgagcc tggaaaaaga acagaaccag 1283041 ttaacgtctg aatccaaccg gcttcaaatt gaccaaattc aagaaaagtt aaaagccttg 1283101 gacagcaaag aaagagaact ggaaaaacag gtaggaaaga aagaagcaga aaaacaaatc 1283161 gaatctgaac ggacagagct tcaaatgcag aaaaaaacag cggagatcga attaaaacaa 1283221 accgagcttc agcggcagtc acttgccaac cgggtgtcag atttagaagt gaaaagcgaa 1283281 attgaaggca ccgttatttc tgtcaaccaa gaagcggcat ccaaaaagtc agatattcaa 1283341 gagcctgtca tacatatcgg caacccaaaa gaccttgtcg tctcagggaa attgtctgaa 1283401 tacgatacat tgaaagtcaa aaaaggccag aaggtcacac tcacttcaga tgtaatacag 1283461 ggtaaaacat ggaaaggcac ggtttccgca gtcgggcttg ttccggatca gcaggagagc 1283521 gctgcggcac aaggaacaga acaggcggtc caatacccgc ttcaagtgaa aataaaagga 1283581 aatcttccag aaggaaagcc aggctttaaa tttatcatga atattgaaac agataaacgg 1283641 aaagcaaata cgcttccttc aaaggcagtc aaaaaagaag atgaccaata ttatgtgtat 1283701 acagtaaaag acggaaaagc aaagcgagtt gatgtcaaaa tcggcgaagt gacagatgac 1283761 ctgacagaaa ttaaagaggg gcttacccaa gatgatcaag tcattttgaa tccatctgat 1283821 caggtgactg acggaatgga agtgaaatcc taaatgattc agctttctaa tgtgcgaaaa 1283881 agctaccaga tcggaaagga aacgtttgat gttctccatt ctattgattt ggacattcat 1283941 caaggtgaat atgtctcgat tatggggccg tcaggatcag gaaaatcgac gatcatgaat 1284001 attatcggct gtcttgatcg gccgacttcc ggtacatatc aattggacgg cgaagacatt 1284061 tcttcatata aagataaaga actggcggca gtccgtaacc ggtccatcgg ttttgtattt 1284121 cagcaatttc agcttcttcc gcggctgaac gcaaaaaaaa atgtcgagct gccgatgatt 1284181 tattccggga taggcaaaaa ggaacgtcaa gagcgggctg agagagcatt ggaaaaggtc 1284241 gggttagccg atcgaatgct ccacatgccc aacgagctgt cgggcgggca gaagcagcgg 1284301 gtggcgattg cgagggcgat cgtgaatgag ccgaaattga ttttagctga tgaaccgacc 1284361 ggcgcgctgg atacgaaaac aagcgaggcg attatggatc agtttacagc attaaatgcc 1284421 gagggaacga caatcgttct ggttactcac gagcctgaag tagcagattg cacgaatcgg 1284481 atcgtcatgg tgcgtgacgg aaacattgtt cctgccagct ccggacaaag gagtgtggga 1284541 gaatgagcct gttggaaaac atcagaatgg ctctaagctc tgtccttgcc cataaaatgc 1284601 gttcgatctt aacgatgctc ggcattatca ttggtgtagg ctctgtcatt gttgtcgttg 1284661 cggtaggaca gggcggcgag caaatgctga agcagtcgat cagcggcccg ggaaatactg 1284721 tggagctgta ctatatgcct agcgacgagg agcttgcaag caacccgaat gccgcagctg 1284781 aatctacgtt tacagaaaac gatattaaag gtttaaaagg aatagaaggc attaaacaag 1284841 tcgttgcttc gacttctgaa agtatgaaag cgcgttatca cgaagaagaa accgatgcta 1284901 cggttaacgg aataaatgat ggatacatga atgtcaattc tttgaaaatc gaaagcggca 1284961 gaacctttac cgacaatgac tttctcgcgg ggaatagagt cggaatcatc tctcaaaaaa 1285021 tggctaaaga gctgtttgat aaaacctccc ctctaggtga agttgtctgg attaacggac 1285081 agcccgttga aattatcggc gtgctgaaaa aagtaacagg cttgctttct ttcgatttaa 1285141 gtgaaatgta tgtgccattt aatatgatga aatcctcttt tggcacaagt gatttcagta 1285201 acgtatcatt gcaggtcgaa tcagcagacg acataaaatc ggctggaaaa gaagcggcac 1285261 agctggtaaa tgacaatcat ggcacagagg attcgtatca agtgatgaac atggaagaga 1285321 ttgcggccgg aattggcaaa gtaactgcaa ttatgacgac gattatcggc tcaattgcag 1285381 gtatttccct tttggtcggc ggaatcggtg tcatgaatat tatgctcgta tcagtcacag 1285441 aacggacgcg ggaaatcgga atcagaaaat cacttggtgc gacgagggga cagattctga 1285501 ctcagttttt aattgaatca gtcgtattga cgctgattgg cggtctggtc gggattggta 1285561 ttggatacgg aggggccgcg cttgtttcag ccattgcggg ctggccgtca ctcatatcct 1285621 ggcaggttgt atgcgggggc gtgctgttca gtatgctcat tggtgttatt ttcggcatgc 1285681 ttcctgcaaa taaagccgca aagcttgatc ccattgaagc gctgcgttat gagtagcctc 1285741 atgcaacatg catgaggttt ttttatgttt agtgatttct actatgaata taaaagactt 1285801 ttttcattaa aataagaaga aaatgtcgta caattgtcct tatttttgtc gaatttacag 1285861 tttacaaacc ctatagacat acgttaatat ggagaaacgt gaaagatttt gatagttatt 1285921 gaatgaattt gaatgatttt agttgcctaa accgaaaata gcgtttacaa tgaaattgta 1285981 ttcaaaatga atacgttttc attaggaggt gaagcatgct aactcctgaa cggcatcaat 1286041 tgattattga tcaaatagaa aagcatgatg tggtaaagat tcaagagctt ataaatctga 1286101 ctaatgcttc tgaatcaaca atcagaagag atttatcgac ccttgaagaa cgcggttttt 1286161 taaagcgcgt tcatggtgga gcggccaagc tttccgatat cagacttgaa cccgatatgc 1286221 ttgaaaaatc atccaaaaac cttcacgata aactgaagat tgctgaaaaa gctgcttctc 1286281 ttttagaaga aggggattgc atttaccttg atgcaggcac gacgacattg cacatgattg 1286341 attttatgga taaaaccaaa gatattgtcg ttgtcacaaa cggggtaatg catatcgatg 1286401 cattaataag gaaagaaatt tctttttatc tgcttggagg atacgtaaag cacagaacgg 1286461 gcgcgattat tggaggcgct tcattggttg ccatggacca gtacagattt gacaagagtt 1286521 ttctggggac aaacggtgtc catacagagg ctggatttac aacgccggac cctgatgagg 1286581 cccttttaaa acagaaagcg atcaaacagg caaaacacgc ttacgtctta gcagaccctt 1286641 cgaagttcgg agaaatttca ttttcggcat tcgccggaat aggcgacgca acaatcatta 1286701 cgactgacgc tgaagagctt acattcgata attaccaaga aaaaactgtc gtaaaggtag 1286761 tgaaaccatg atttacactg taacacttaa tccatctgtc gattatatag ttcacgttga 1286821 agattttact gtaggaggcc tgaaccgttc ttcgtatgat accaagtatc cagggggcaa 1286881 aggcatcaac gtatcgagac tgctgaaaag acaccatgtg gcgtctaaag cgctcggatt 1286941 cgtcggcgga tttaccggag aatatatcaa aacattttta cgggaagaaa acctggaaac 1287001 agctttttct gaagtaaaag gggatacccg tatcaatgta aagctgaaaa cgggtgatga 1287061 aactgaaatt aacgggcagg gaccgacaat ttcggatgaa gatttcaaag cctttttaga 1287121 acagttccaa tctttgcaag agggagatat cgttgttctt gcaggaagca ttccatcttc 1287181 actccctcac gatacttatg aaaaaatcgc agaggcctgc aaacagcaga acgcacgagt 1287241 tgttctggat atctcaggcg aggctctttt gaaagcaaca gaaatgaaac catttttgat 1287301 gaagccaaat catcatgagc ttggagaaat gttcggcacg gccattacat ctgttgagga 1287361 agccgttcct tatgggaaaa agcttgtaga acaaggcgct gaacatgtaa tcgtatcaat 1287421 ggccggagac ggagcgcttc tgtttacgaa cgaagctgtt tattttgcta acgtgccaaa 1287481 ggggaaattg gtaaactcag tcggagcagg ggattccgtt gttgcaggtt tccttgccgg 1287541 aatttccaaa cagctgccgc ttgaagaagc attccgctta ggagttactt caggcagtgc 1287601 taccgcgttc tctgaagaac ttggaacaga agaatttgtc cagcagcttc ttcctgaagt 1287661 taaggtcaca cgtctataga ggaggaaaca caagtgaaaa taactgagct tttaacgaag 1287721 catacgataa agcttaatat tgagagcaaa gaaaaagaaa atgttattga cgaaatggtc 1287781 actgttcttg ataaggctgg aaagttaaat gaccgacaag cctataaaga agccatttta 1287841 aatcgcgaaa gccaaagctc cacgggtatc ggtgaaggaa tcgctatccc ccatgcgaaa 1287901 acggcaagcg ttatcaaccc ggcgatcgcg ttcggacgtt caaaagacgg cgtcgattat 1287961 gaatcattag acggccagcc ggctcactta gtgttcatga tcgcggcgac tgaaggcgca 1288021 aacaacactc accttgaagc attgtcaaga ctttcaacgc tgttaatgcg tgaagaaatc 1288081 cgtaagcagc tccttgaagc tgagtctgaa gatgccatca tcgacattat taatcagcac 1288141 gataaagatg atgacgaaga ggaagaggaa gaagaagcgg caccagcacc tgccggaaaa 1288201 gggaaaattt tagcggttac tgcatgcccg acaggtattg cccatacatt catggctgcg 1288261 gatgccctta aagaaaaagc gaaagagctt ggtgtggaaa ttaaggtcga aacaaatggg 1288321 tcaagcggca ttaagcacaa gctcactgcc caagaaatcg aagatgcacc tgcaatcatt 1288381 gtcgcagcgg acaagcaggt tgaaatggaa cgttttaaag gcaagcgcgt acttcaagtt 1288441 cctgtaacgg cgggtatcag acgtccgcaa gagcttatcg aaaaagcgat gaatcaagat 1288501 gcgccgattt atcaaggcag cggcggcggt tcagcagctt caaatgatga tgaagaagcg 1288561 aaaggcaagt ctggaagcgg tatcggaaac acgttttata agcacctgat gagcggtgtc 1288621 agcaacatgc ttccgttcgt agtcggcggc ggtattctcg ttgcgatttc attcttctgg 1288681 ggaattcact ctgctgatcc gaatgatcct agctacaaca cgtttgcagc agcattaaac 1288741 tttatcggcg gcgacaatgc attaaaactc attgttgcag ttctggccgg tttcattgcg 1288801 atgagtattg cagatcgtcc tggttttgcg cctggtatgg tcggcggatt tatggcaact 1288861 caagcgaatg ctggattctt aggcggctta attgccggat tccttgccgg ttatgtcgtg 1288921 attttactga aaaaagtatt tacgtttatc cctcagtcac ttgatggatt aaaacctgtt 1288981 ttgatttacc cgctgttcgg tatttttatc actggcgtat taatgcaatt tgtcgtcaat 1289041 acacctgtag cggcatttat gaatttctta acaaactggc ttgaaagcct tggtactgga 1289101 aaccttgtgt taatgggtat tatcttgggc ggcatgatgg cgatcgatat gggcggtccg 1289161 cttaataaag cagcctttac gttcggtatc gccatgatcg atgcaggcaa ctatgcgcct 1289221 catgcagcaa tcatggccgg cggtatggtt cctccgcttg gtatcgcact tgcaacaacc 1289281 attttcagaa acaaattcac tcagcgtgac cgtgaagctg gtattacatg ctatttcatg 1289341 ggagctgctt tcgtaacaga gggagcgatc ccatttgctg cggctgatcc gcttcgcgtc 1289401 ataccagctg ctgtagtcgg tgcagctgtt gccggcggat taactgaatt cttccgagta 1289461 acgcttccgg cgcctcatgg aggagtattc gtagctttca ttacaaacca tccgatgctt 1289521 taccttttaa gtatcgtgat cggtgctgtc gtgatggcaa ttatcctcgg tatcgtcaaa 1289581 aaacctgtta cagaaaaata agaaaaaaag cgtccttggt tcgaaaggac gctttttctt 1289641 atccggccgg cagggagcgc ggttaagtta tgtattttat tcttttttat gataaagtaa 1289701 aagaagagaa acaactgaca tagcaattgt ctaggaggaa acactttgac cgaggaaaaa 1289761 aatacgaata ctgagaaaac ggcgaagaaa aaaaccaata cgtacctgga atggggtaaa 1289821 gcgattgtca tcgctgttct gctggctctc ctgatccgtc actttttgtt tgaaccgtat 1289881 ttagttgaag gttcatctat gtatcccaca ttacatgacg gagaaaggct gtttgtgaat 1289941 aaaacagtca actatatcgg cgagctgaag cgcggagata tcgttattat caacggtgaa 1290001 acttctaaaa tccattatgt aaaaagattg atcggaaagc ctggagaaac cgttcaaatg 1290061 aaggatgaca cgctttatat aaacggtaaa aaagtagccg agccttactt gtctaaaaac 1290121 aagaaggaag cagaaaaact tggtgtcagt ctgacaggag actttggacc ggttaaggtt 1290181 ccgaaaggca aatactttgt catgggagat aaccggctga attctatgga cagccgaaac 1290241 gggctgggac tgatcgcgga agatcgaatt gtcggcacat cgaagtttgt ctttttcccg 1290301 tttaacgaaa tgcgtcaaac aaaataaaaa cgccttgctg gcctaggaca gcaggcgttt 1290361 ttattttgaa aaagaagcga ccaatgcaat gcataaaacc gtgatgaaca ctgaaccgat 1290421 aatagccagc acactgaaga aaaggtgaac ctgtttgttc tcttttccgc gcttttctaa 1290481 tagccgttta gaaaaaatgt gcgaaaatat gtaaataagg gctatgccta tatataagcc 1290541 gatatctttg gcggtaaagc ctgttacggc aaggtaaaag cccgtaaaaa agatcagtaa 1290601 gcaatattca gtaagtgtta aaagcctcaa cgtgttcctc catgagagtg tgtaattttc 1290661 caggcggatg cattctctct ctttaattgt aacacagctg gctggtttgg gtgtataagt 1290721 gttttctctc tgttttatca gggaatcatt tctcttgccc tgcattcatg gtatactttt 1290781 attgatgata gacatgatgg aggataataa atgattgctg taaataatgt aagcttgcgg 1290841 tttgcggatc gcaagttatt tgaagatgtt aatattaaat ttaccccagg caactgctat 1290901 gggttaattg gtgcaaacgg tgccggtaaa tcaacgtttc taaaggtgct gtcaggcgaa 1290961 atcgagcctc agacaggcga cgtgcatatg agtcctggcg agcgtcttgc cgtcttgaag 1291021 cagaaccatt ttgagtacga agagtatgaa gtgctgaaag tggtcattat gggccacaaa 1291081 cgcctgtatg aagtcatgca ggagaaagac gctatttaca tgaagcctga tttctcagat 1291141 gaggatggga ttcgtgctgc tgagctagaa ggtgaattcg cggaactgaa cggttgggaa 1291201 gcggaaagtg aagctgcgat cctgttaaaa ggccttggta tctcagaaga tctgcacaca 1291261 aaaaagatgg cagacctcgg cggttcggag aaggtaaaag ttctcttggc acaggcatta 1291321 ttcggcaagc cggatgttct gctgctcgat gagccgacga accacctgga ccttcaggca 1291381 attcagtggc ttgaagagtt tctgattaac tttgaaaaca cagttattgt cgtatcccat 1291441 gaccgtcact ttttaaataa agtatgtacg cacattgccg accttgattt taacaaaatt 1291501 caaatctatg tcggaaacta tgatttctgg tacgagtcaa gccagctggc gttaaagctt 1291561 tctcaagaag cgaacaagaa aaaagaagag cagattaaac agcttcaaga gtttgtcgct 1291621 agattcagcg ccaatgcgtc taaatctaag caggctacat caagaaagaa acttctcgaa 1291681 aaaatcacgc tggatgatat taaaccgtct tcccgccgct atccttatgt taacttcacg 1291741 ccggaacggg aaatcggaaa tgatgttctt cgcgtggaag gcttaacaaa aacaatcgat 1291801 ggcgtaaagg tgcttgacaa tgtcagcttt attatgaatc gagaagataa aattgctttc 1291861 actggccgaa atgaacttgc tgttactacg ctgtttaaaa tcatttccgg ggaaatggaa 1291921 gctgacagcg gaacgtttaa atggggtgtt accacatctc aagcgtattt tccaaaagac 1291981 aacagcgaat atttcgaagg cagtgatctg aaccttgtag actggcttcg ccaatattct 1292041 ccgcacgacc aaagtgagag ctttttacgc ggtttcttag gacgcatgct gttctctgga 1292101 gaagaagtcc acaaaaaagc aaatgtactt tccgggggag aaaaggtccg ctgtatgctg 1292161 tcgaaagcga tgctttctgg cgccaatatt ttaattttgg atgagccgac caaccattta 1292221 gacctagagt ccattacagc gctcaataac ggcttaatca gctttaaagg cgctatgctg 1292281 tttacttccc atgaccatca gtttgtgcag accattgcca acagaattat agaaattaca 1292341 cctaacggca tcgtcgataa gcaaatgagc tatgacgagt tccttgaaaa tgctgatgtg 1292401 cagaaaaaat tgactgaact atacgccgaa taaaaaagca gagatttctc tgcttttttt 1292461 gatacctaaa tgtgaaagga gatcacaaca tgaaattttt ggttgtcgga gcaggtggag 1292521 taggcgggta tattggcgga cggctttcgg agaaaggaaa tgatgtgaca tttctcgtgc 1292581 gccaaaaacg agctgagcag cttaaaaaaa ccgggcttgt catccatagt gaaaaaggga 1292641 atgtatcatt tcagcccgaa ctaatcagtg ccggagaaac agggcaattt gatgtcgtta 1292701 tcattgcttc taaagcatac tcgcttggtc aagtgataga ggatgtcaaa ccatttatcc 1292761 atcaagaatc tgtcattatc ccttttttaa atgggtaccg ccactatgag cagctatttg 1292821 cggcattttc aaaagaacag gtgctgggcg gcctgtgttt tatagaaagt gctttagaca 1292881 acaaaggaga aattcatcat acgagcgcat cgcatcgttt tgtatttgga gaatggaacg 1292941 gcgagcgtac ggagcggata agagcgcttg aagaggcatt ttcaggtgtg aaggctgaag 1293001 tcatcattag cgggcatatc gagaaggaca tttggaaaaa gtatctcttt attgcagcgc 1293061 aagcggggat cacaacgtta tttcaacgac cgcttggccc aatcctcgcc acagaagccg 1293121 gacgtcacac ggcccaaact cttattgggg aaatttgcac tgttttacga aaagaaggtg 1293181 ttccggctga tccggctctt gaggaagaga gctttcgtac gatgaccagc atgtcttacc 1293241 atatgaagtc ctccatgctt cgggatatgg aaaacggcca aacgacagaa ggcgaccacc 1293301 tgcatggatt tttgattgaa aaagcaaaac gtttatctct cgctgcacca gtattagaaa 1293361 ccgtttatgc gaatctgcaa atgtatgaag cagaaaaata aaaaaaggag gcggaaaagc 1293421 ctccttttat ttacttaaaa agcccaattt ccgtttctga agataggctc tcttttcccg 1293481 tctgccgtaa ttccgtcaat attcatatcc ttagaaccga tcataaagtc cacgtgtgta 1293541 atgctttcat ttaggccttc tttgacaagc tcttcacgag acatctgctt tccgccttca 1293601 atattaaagg cataggcgct tccgatcgcc aaatgatttg acgcgttttc atcaaacagc 1293661 gtgttataga aaagaatgtt tgattgtgat ataggcgaat cgtaaggaac aagtgccact 1293721 tcacctaaat agtgagaacc ttcatctgtt tccaccagtt cttttaaaat atcctcacct 1293781 ttttcagctt taatgtcgac tatacggcca ttttcaaacg tcagggtgaa attttcaata 1293841 atatttccgc cgtagcttaa tggttttgtg cttgatacca ctccgtcaac cccgtctttt 1293901 tgcggcagcg tgaacacttc ttctgtcggc atattggcca taaactcatg gccactttca 1293961 ttcacgcttc ccgcacctgc ccaaacatgc ttcctaggca gcttaattgt tagatcagtt 1294021 ccttctgctt gataatgtaa ggcagcgtaa tgtctctcgt tcaaatggtc aactttttca 1294081 tgaagatttt ggtcatgatt gatccacgcc tgaaccgggt tgtcttcatt tacgcgcgtc 1294141 gctttaaaaa tttcttccca cagaaggtgg atcgcttcct cctctgattt gccaggaaac 1294201 accttgtgag cccagcctgc tgatgccgca cctacgacag tccagctgac tttgtctgat 1294261 tgaatatatt gtctgtatgt atgtaatgct ttgcctgctg ctttttggaa tgccgcaatc 1294321 cgtttggaat ctataccttt tagcaagtct gggttcgacg acacaacaga aatgaaagca 1294381 gctccatttt tggcaagctc ttctctgcct tttgcttccc attcaggata ttcttcaaat 1294441 gcttcaaacg gcgcaagttc gtattttaat ttggcgactt cgtcatcctg ccaattcacg 1294501 gtgacgtttt ttgcgccctt ttcatatgcg tgttttacaa ttaaacggac aaaatcccga 1294561 acgtctgttg aagcatttac gactacatac tggccttttt ggacattaac gccgacttct 1294621 accgccagct gtgcatatgt atttaatttc tgtgaaaatg aatccatgaa tcattcctcc 1294681 aagctttttt ctcatcatat caaatatgat cctataaagg aaagaaggag cccaaagtga 1294741 aaaacccaaa acgacacgtc ttgggttttt tcaatattat ggatgattca gttttacagt 1294801 gccgcctgca ggcgaatggg gcatatttgc caaagaaatg ctcatgcctc caagaataat 1294861 tccgcttaaa atggctgcga tcgctactct tcttcctaaa tctcttagca tctgtttcct 1294921 ccttaacgtt tctccatttc ccacaatatg aaggaagtga ggaaaaaaga agcaagaaat 1294981 ttgccgcgtg tgagaatttt gcgggtaaag actatttaat tgccttttgc agcttatcaa 1295041 tcacttctaa agaacggcct gtgccgattg ctacagattc aagcgggttt tgcgccacgt 1295101 gtacaggcac gacaatctct tctgtgagcc attctttaat tccattaagg agcgcgccgc 1295161 cgcctgttaa aataacgccg cgatcaacaa tatctccgct caattcaggc ggacagtcct 1295221 caagtgtcgc tctgatggct tcaagaatat gcaggaggga ttcacgcatt gcatcttgaa 1295281 tttcgttgga ttgaagcata atggtttttg gaagacctgt cacgaggtca cgtccccgaa 1295341 tttccattgc ctctggtata tgttcaatca gagcatggcc aatttccatt tttacctgct 1295401 cagctgtgcg ttcgccgatc agcaaattgt attttttacg gacgaaagaa acgatatcct 1295461 catcaagctg gtctccgccg atcctgatag aatggcagga aacaacgcca ccgaaggaaa 1295521 taatagcgac ctctgtcgtc cctccgccga tatctactac cacattggca accggctcat 1295581 caaccggtaa atccgctccg atggcggctg caactggctc ttcgattaaa tgaacgtttt 1295641 tcgcgccgca atttttcacc gcatcactga tggcgcggcg ttctactgct gttgagcctg 1295701 atggtgtgca aacgactacg ttcggttttc tgaacgacat gccgatgctt tttgcggctt 1295761 ttttcataat gtgctttagc aggtcagttg tcatatcata gtctgcgatc acgccatctt 1295821 tcatcggtct gacagcgaca atttttcccg gtgttttacc gatcatgttt ttcgcgtcag 1295881 ctccgattgc aagcactgct tttgtcgtcg tatccactgc gacaacagat ggttcattta 1295941 ggataatccc tttatttttg ctgtaaacaa gtatattagc tgttcctaag tcaatcccga 1296001 tttcagttga ttgaaacatg ttttcaccca atctctatcc taatttaata tgattctaca 1296061 tttaaagttt ctcagaaata ctgcgatttt tgggggtgtg cgtcggtaaa gaaatgtttt 1296121 tgtaaaaaat caaggaactg tgtaacagaa gtaatacatt tttcggtttt atggaaaaaa 1296181 tatcttgtaa ttcttataga aagcgggaaa ctttttcaaa gtttcattcg tctacgatat 1296241 attgaggtac atccttaaaa cattacatga gaaaagaaac atttaaagga agaagggttt 1296301 ttatgaaatc aataggtgtt gtgagaaaag tagatgaatt aggccgcatt gtcatgccga 1296361 ttgagttgag acgggcattg gatattgcca taaaagacag cattgagttt tttgttgacg 1296421 gagataaaat tatcttgaaa aagtacaaac ctcatggcgt ttgtttaatg actggagaaa 1296481 tcacttcaga aaataaagaa tacggcaacg gtaaaattac gctaagccct gagggtgcac 1296541 agctgcttct cgaagaaatt caagccgctt taaaagaata aaattatgct aaaaaaggcg 1296601 gagtgatatc atctccgcct tttttgcgtg ccaatttttg attaccgccg cctaagataa 1296661 gacatcaaga tatttggtaa tgaatgattt gggatacttt acatatttta ctcaattatt 1296721 tgtcgaagaa tggtacaata agtagagaaa cacaagcggc aggtggtcat atgagaaaat 1296781 atcaagctcg tatcatttcc atcattttgg caatgatttt tataatgttt tgggattatt 1296841 tattttattt tataggcaaa aacccgatta attggcctgt tgatattgtg tatactgcag 1296901 tcacgctggt aagtgtctgg atgttggctt attatattga tgagaaacag cagctggtta 1296961 agaaaatgaa ggataacgaa tggaagtata aacagctttc tgaagaaaaa aaccgcatca 1297021 tggataattt gcaggaaatc gtatttcaaa cgaatgcaaa aggtgaaatt acatatttaa 1297081 accaagcgtg ggcatctata accgggtttt caatcagtga atgtatggga acaatgtata 1297141 acgattactt cataaaagaa aagcacgtag ccgaccacat taacacccaa atccaaaaca 1297201 aagcgtcttc tggcatgttt acggcaaaat acgtgacaaa aaacggcacg attttttggg 1297261 gagaagttca ttataaactt tactatgacc gggatgacca atttacaggc agcctgggta 1297321 caatgtcaga tatcactgag cggaaagagg ctgaagatga gctcattgag attaatgaac 1297381 ggctggcgag ggaatcccag aaactatcaa tcacaagtga acttgccgca ggtattgctc 1297441 atgaggtcag aaacccttta acatctgtca gcggtttcct ccagattatg aaaacacaat 1297501 atccggacag aaaagactat tttgacatca tcttttcaga gattaaaaga atcgatttag 1297561 tgctcagcga gctgctgctg cttgcaaaac cgcaggcaat cacatttaaa acacaccagc 1297621 ttaatgagat cttgaaacaa gtcacgacat tgcttgatac caatgcaatt ctgtccaata 1297681 tcgtcataga gaaaaatttc aaagagacag atggctgtat gattaatgga gacgaaaatc 1297741 agctgaagca ggtctttatc aacatcatta aaaacggaat tgaggcaatg ccaaagggcg 1297801 gtgtcgtaac catttcaact gctaaaaccg cctctcatgc agtgataagc gtaaaggatg 1297861 aaggaaacgg catgccgcag gaaaagctga agcagattgg caaacctttt tattcaacaa 1297921 aagaaaaggg cactggactg ggacttccca tttgtttgag aatcctgaag gaacatgacg 1297981 gggaattgaa aatcgaaagt gaagctggaa aaggcagcgt ctttcaagtg gttttgcctt 1298041 taaaatcaga cagctgagag gagaaaaata aagtgaactc gcttctgttt gtatacggga 1298101 cattaagaaa gcatgaaaaa aaccatcatt tgctggcaca atcggcatgt atcaatgagc 1298161 aggcgagaac aaagggaagt ttgtttgctg caaaagaggg gcccacagtt gttttcaatg 1298221 atgaagatga aggctatata tatggcgaag tatatgaagc agatgaattg tgtatacata 1298281 agctcgatca attttttcaa ggatatcata aacaaacggt gtttgtagaa acggatgtcg 1298341 ggattaaaat tgcgcttatt tattttatga acaaagacgg gtgtgccggt tttacgaaaa 1298401 taagcagcgg cgactggaaa gaacatcaga tgatcagcaa atcgaaaaat cccatttatt 1298461 attttgccta tggatcatgc atggataatg cccgctttca aaaagcggga gtcgatcact 1298521 attttcaaga tccagtagga agagctgttt taaaaggata cacaacccgc ttcacgctaa 1298581 aaagggaaga cggttcaaga gcggacatgt tggaagacgg aggaacaaca gaaggcgttt 1298641 tataccgtat cccttattct gctctctcct atctatataa aagggagggc gtcgaatctc 1298701 ttacgtatcg gccggcattt gtagacgttg aagctggcgg aaggcactac aaagactgtt 1298761 taacctttct cgtcctccaa aaagaagcgg aaattgcccc gcctcagcac tatcagattg 1298821 aaatcgaacg cggagcggag ctgtatttgt cgcctgagtt tactgaaaag ctcaagcggc 1298881 atatgaattc gctgccaaaa ggataacact gtaacaaaag aatatgataa aatttgatca 1298941 atatcatgtc atataaagga gcaccacgat gaaaaaagaa tttgcggtaa ttgggctggg 1299001 ccgttttggt ggcagtattt gcaaagcatt aagcgaagaa ggcgtcgagg ttatggcaat 1299061 ggatatcgat gaagataaag tcaacgagta tgccaagatt gcatctcacg cagttatcgg 1299121 tgattcgaca gacgaatctg tcctgaaaaa tttaggcctg cgaaattttg accacgttat 1299181 tgtagcaatc ggggaaaata ttcaagcgag tattttaacg acactcattc tgaaagaact 1299241 tggcgtccat acgattacag ttaaagcgca gaacgattat cacgaaaaag tgctgtctaa 1299301 aattggtgcg gatcacatcg tccacccgga acgcgatatg gcaaaacgaa ttgcgcataa 1299361 tatcgtgtcc aacaatgtac ttgactattt ggagctgtct gaagagcata gtcttgttga 1299421 aatcgtagct aacagccgcc tggctggaaa tacgcttctc gatttagata ttcgcgcaaa 1299481 atacggtatt aacatcgtag ccataaaaag gggcaaggaa gtcatcgtat caccgcttgc 1299541 aaccgaagtc atccaccaag aagatatact cattgttatt ggatcagtta cagacatctc 1299601 ccgtttcgaa aaaagagttc ttcatacaaa atagcagcca aataagccgt cctcaaaggg 1299661 cggtttttca tattatcaga atataacaac tttaatgaac tgagcgtcaa tttcttaaaa 1299721 tttcattgac taagcacagg cgttccgata gcatattgta ccatataata aaaaaaggag 1299781 gggcctattt gaataaagaa gcgctagtca ataggctgaa tgcttcagcc aaaagacaaa 1299841 aagctgatat cgtcattaaa aacggaaaaa tcatggacgt atataatcaa gaatggatat 1299901 atgaagatat tgcgattaca gatggagtta ttgtaggcct cggtgagtat gaaggcgaaa 1299961 atatcattga tgcagaggga caaatgattg ttccgggttt tattgatgga catgtacata 1300021 ttgagtcgtc aatggttaca ccgattgagt tcgctaaagc agtgttgcct catggcgtga 1300081 cgacggttgt tacagatccg catgagatcg cgaatgtgtc tggtgaaaaa gggattgagt 1300141 ttatgcttga acaagctcgg catacaccgc tgaatatcca ttttatgctt ccttccagtg 1300201 tgcctgccgc aagttttgag cgatcaggcg caattctcaa agctgccgat ctcaagcctt 1300261 tttatgaaga agaagaagta ttagggctgg ctgaagttat ggattatgtg tcggttcagc 1300321 aggctgaaaa agacatggtt cagaaactgc ttgatgcccg tgtggcagga aaaaggatag 1300381 acggtcattt agctggttta tcaacagacc tcattaacat ttacagaacc gcatttgtct 1300441 taaacgacca tgaagtaaca tcgaaggaag aagcccttga tcgtatcaga aggggcatgt 1300501 atgtcatgat gcgtgaagga tcagtcgcca aaaacacgct caatgtgctg ccggcggtga 1300561 atgaaaagaa cgcacgccgg ttctttttct gtacggatga taagcatgtg gatgatttat 1300621 tgtcagaggg aagtgtaaac catcaggtga aaatggcgat tcaagccgga cttaatccgt 1300681 ttttagccta tcagctagga agcctcaatg cagccgaatg ctacggatta gatacaaagg 1300741 gagcgattgc cccgggtttt gacgctgatt tgctttttgt atctgatctg gaaaatgtca 1300801 ctgtcacaat gacgatggta aaagggcaga ctgttgctga agacagcaaa gcggtctatc 1300861 aggatcatgc ttcaactgca gcaccagatc aggcactgct tgattctgtt aagcttgctg 1300921 ctcctcttaa caaacaggat tttcatatgc caatcgattc agagcagcag atcaatgtca 1300981 ttcaaatcat accaaatcag cttgaaacac gattagtaca agttccggct cctgttgccc 1301041 gcgaatttga gcctgacact gagcttgatt tgttaaagat tgcagttgtc gagcggcata 1301101 aaggattaaa agaaaccgga cttggtgttg tgaaaggttt tggattcaag agcggagcga 1301161 ttgccacaac catttcacac gactcccata atattattgc cgtcggaacg aatgatgagg 1301221 atatcgcggc ggcagttaat aagctgcagg aaattggcgg aggattaaca attataaaaa 1301281 atggggaaga gctccattca gtaccgctgc cgattgcagg gttattatcc gaccaatctg 1301341 cagagcaagt gaatcaaagc ttgctgacgc ttcatgataa attgtcgtta atcggtttca 1301401 caggcggatt taatccattt ttgacattgt cgtttttagc gttgcctgtc attcctgata 1301461 ttaaaatgac gactacggga ttattcgatg taaaatcatt tcaacacata tcactgcaat 1301521 aaaaagaggc actcccttag ggagtgcctc tttttttaaa cctccataat gatcggcagg 1301581 atcattggac ggcgctttgt tttttcgtac aagaaaggtg caagcgtgtc tgtaatttcg 1301641 tttttgattt cagaccattg agtcgttttt cgttccatta ctttttgtaa gtgatttgaa 1301701 atgagctctt gagcgtcgtt gatcaagtca ccagattctc tcatgtacac aaatcctctg 1301761 gaaatcaaat caggacccgc tgaaatcttg aagtcgtcca tgtcaatgct gacaacaacg 1301821 atgacaagtc cttcttcaga gagaattctg cgatcacgaa gtacgatatt gccaatatca 1301881 ccgataccgc ttccgtcaat gtacactgaa ccggacggga tttttcctgc aactgaagcc 1301941 tcatcgcctt taagtgctaa tacttcacca ttatccatga taaagcagtt ttcctctggg 1302001 atgccacaat ctgttgcaag tttgacatgc atcttttgca ttctgtactc accgtgaatc 1302061 ggcatgaaga atttaggctt gattaaacga agcatcagct tctgttcttc ctgtccgccg 1302121 tgaccggatg tatggatatc gttaagaggg ccgtgaataa cctcagcacc cgcacgatac 1302181 agctggttga ttgttcgact cacgctgatt gtgttgcctg ggatagggga tgaagaaaat 1302241 acgactgtat ccccaggatt gattgaaatt tggcggtgtg tgccgtttgc aattcttgat 1302301 aacgccgcca ttggttcccc ttggcttcct gtacataaaa ttgttacttt attagcaggc 1302361 atacgattga tttcgttatg ctcaataaac gtatttttag gacagttaat ataaccgagt 1302421 gtctgtccaa tttcgatagc cgattccata ctgcgtccaa atacggcaac ttttcttcca 1302481 ttttgtacag cagcttcaat tacctgctgc aagcggtgaa tattcgacgc aaatgtggcg 1302541 aagataattc ggccgtccac cttgcggaaa atgtcatgaa tgctttctcc tacacggcgc 1302601 tcagacatgg taaactccgg attttcactg tttgtgctgt ctgaaagaag gcacaaaacg 1302661 ccttctttac cgatttcggc cattttcgtt aagtttgccg gctcgccgac tggagtaaag 1302721 tcgaatttga aatccccagt atgtacgatg tttccgggcg gcgtttttac aacaatgccg 1302781 taggaatccg gaatactgtg tgttgttctg aagaatgaca cagccgtttt gcggaacttt 1302841 acaatatcat cctcgccgat aatgttcagt ttcgtctgtc tcaataatcc atgctcttca 1302901 agtttattcc gaagtaagcc gatcgcgagt tttccgccgt atacaggaat attcacttgt 1302961 ctgagcaggt atggaatacc gccgatgtgg tcttcgtgcc cgtgggtgat aaaaagccct 1303021 ttaattttat cttcgttttt gactaaatac gtataatcag ggatgacgta gtcaattccg 1303081 agcagttcgt cctcgggaaa cttgatcccc gcatcaatca gtacaatttc atcctggaat 1303141 tgcaccgcgt acgtattttt accgatttcg cccaaacctc cgagggcgaa aacagcagtc 1303201 tgatcatttt ttacaaattt cataccgctc ataactccaa tactttaaaa ttttcgctct 1303261 gttgttcata ttctaagaat gcaccatcaa caggtgtaat aaactcaata ttaaatttct 1303321 tttctttcag ctttgttctg acgtcacgct cagatacgcc ttcaatataa agtgaatctg 1303381 tcttttcccg aacaggtact tcgtcagcct tctcttgata aaatacctta taaatcattc 1303441 caaatctctc cttaaatgcc gtatgttaga ctcgctcatt ctattatatt cgaaaacgga 1303501 atataaggaa agccttgagc aaaataagga tctctcaaaa agtgaaagat cccttgtcag 1303561 gcaattgctt tcttacggag cattccgttc cattgtcttc tgagtttctt tcttaattta 1303621 cgcagcatta gccagtccct cctttaatga aaaatttgtc ccagagttct tttatacaaa 1303681 tagtatacgg agattgagga agacttttcg tggttattaa tggaatttaa tatgattttt 1303741 gaacgaaatt gtttgctgaa tgacaatctt tttgtatgat gagggtggga attgcagacc 1303801 aagacgataa aggggaagtt gcgatggatt ctaaattaat cttttttgat attgacggca 1303861 caatatatga tcatgataag aatataccgg aaagtacgag aaaaaccgtg gcggagcttc 1303921 agcgccaagg gcatcatgtg tttattgcca gcggccggtc tccatttttg gttaagccga 1303981 ttttggagga gctgggcatc cactcattta tttcctacaa tggacagttt gttgtctttg 1304041 aaaatcaagt gatttataaa aatccgctgc ctgaaaatgc aatcaggcga ttattaaagc 1304101 aggcggatga aggcaagcat cctgttgtgt ttatggctga ggacacgatg aaagcgactg 1304161 ttgcggatca cccccatgtt ctcgagggaa tcggcagcct taaaacagat tatccagaga 1304221 ccgatgacct tttttatgaa ggaaaagaaa tttttcagct tcttttattt tgtcaggatg 1304281 aagaagaaaa agcttatgcc gcttttcctg agtttgatct agttcgctgg catgagctat 1304341 cgactgatgt tctgccgcac ggaggttcga aggcagaagg aatcaaaaaa gtgattgagc 1304401 gtcttccgtt tgatatcggc gatacatatg ctttcggcga cggattaaat gatttgcaaa 1304461 tgattgaata cgttgggaca ggcgttgcta tgggaaatgc tgttcccgaa ctgaaagaaa 1304521 tcgcggactt tgtaacaaaa ccggtggacg aggatggaat tgcatacgct gtcaaagaat 1304581 tgggcctttt aaaataaaga aacggctggc attgtgccag ccgttttctc ttttagcgct 1304641 caattgcgat tgcattttca ggttctttga aaggattttc cttatcaata tgatcataga 1304701 acataacgcc gttcaaatga tcgatctcat gctgaaacac aatagccgga aatcctttta 1304761 aacgaatatc aatattttcg ccttctagtg ttgttccttt tactctgatg cgagcatagc 1304821 ggggaacata accgggaatc gcttcatcca cagagaggca gccctcgccg cttgttaagt 1304881 agcttttttc aactgaatgg ctgacgatct taggattaaa cagagcatag ctgtataatt 1304941 taccggaagc atcttccgca tgaacggcga tcattcgttt tttgatatta atttgaggag 1305001 ctgcgagtcc tacgccaggg cgcagcttgt atttttcggc taattctgga ttttggctgt 1305061 ttttaacaaa ttcgatcatg tcggccagct gctgtttttc tgcatcagtt ggaggcagct 1305121 caacaggttc ggcagtctct ctgagggctg gatggccgtc acgtacgatg ttttccatag 1305181 taatcaagaa acttcactcc taaagcttaa tatgtaaatt atatcggatt tcttcacaaa 1305241 ggtgcaacga aacgaatgac cagccgtata tggctggtca atttcatgct gtgtggttag 1305301 caacagcctc cacctaaata agcagctccg acaatgatta acagaatgaa taaaacaacg 1305361 attagcgcaa aggtgcggcc gtagccatat ccgcagccac catatccgta accaccataa 1305421 ctgcagcagc ctccgccgta accatatcca tacatattac ataacctcct cttttaatta 1305481 cgccagagcc tttataagta ggcatagcgt ctaatataac ctatgtaaaa acaaaaaagt 1305541 tgtatggtca tctgtcctga tttttcactt ttttgattta atttcagtat tgcatttata 1305601 cagcacggct attgccaaat gtccccatgg attctatagt agaaattgtc aagattgggg 1305661 gatttaacgt gaaagacgct ataaaacggc ggcctggaat caagatcgga gctttttgtg 1305721 ccatggcact gatattaaca ggatgcatgg gacaggaccc ggttgattca cttcatcatt 1305781 cattagaaaa agccgcggaa tcggaaaagc cgtttcaaga agaacaaaac acactcaaag 1305841 aattagaggc caaagaaaat cagctttacg atagtgttat gaagctcaat atggatgatt 1305901 ataaaaaaat tgttgcttta tctaataagg cgcttgaaaa tgtcagcaag cgcgaagaac 1305961 acctaaagct tgaaaatgac agcatgaaaa aatcggaaac agaatttgag gaagcaaaaa 1306021 cgtcagcgga acatattaag gaaaaagaca taaaagaaaa ggccgatgcc gcagcaaacc 1306081 atatggagaa aagatataca tcatatggca ctatgtataa agagtataaa aaagcgcttg 1306141 agcttaataa aaaactgtat atgcagctga aagacaaaga tttgacaaga gatgatctgg 1306201 atcagcagat cgataaagtc aatgcttctt atgaaaagat ccttaaatat agcggagaat 1306261 ttaatgaaca aaccgaaaaa tataataaag cccgggaaga tttatatgat gctgcaggct 1306321 atcgtgtgaa aaagagctga ctcgatcagc tctttttttg aatgaaatgc gattcggatt 1306381 tcgttcaaaa ttttcatttc tattgtagta cagcatagta aggtatacta gtacagtttt 1306441 gggtgcggtt ggcatctgtt tttttgatga aaatgtaaag cgaatacatt tattgaaaat 1306501 cagcgatgaa aacgattgac ggttcttctt tatttggtgt aaactaatcc atgttaagcg 1306561 gtgttgtatt agttttttac aacttcgaaa taatacagtt caaagcagag tgtaactatc 1306621 ctacataaaa ggttttggca aactggggat cggctaaaat ataatacgac ttactgctga 1306681 tactttaggg taccctaagt ttgtatgtat aaaaggaatg cacgtctaat gactgtttaa 1306741 aagaaaggaa gaggtgactt agtatggctg caaaaacgaa aaaagctatc gttgacagta 1306801 agaagcaatt tgatgccatt aaaaagcagt tcgaaacgtt ccaaatttta aatgaaaagg 1306861 gagaagtcgt gaatgaagcg gcgatgcctg atttaactga tgatcaatta aaagagctaa 1306921 tgcgccgcat ggtatttacg cgtgtgcttg accaacgctc tatctcatta aaccgtcaag 1306981 gacgtctcgg attttacgct cctactgcgg gtcaagaagc ttctcagatt gcaacgcatt 1307041 tcgcgcttga aaaagaagac tttgttcttc ctggataccg tgatgtgcct cagttaattt 1307101 ggcacggcct tccattatat caagcgtttc ttttctctcg cggacatttc agaggaaacc 1307161 aaatgcctga tgatgtgaat gccctttctc cacaaatcat tatcggtgct caatacattc 1307221 aaactgccgg tgttgcgcta ggtcttaaaa aacgcggtaa gaaagctgtc gcaatcactt 1307281 acactggtga cggcggagct tctcaagggg acttctacga aggaattaac tttgccggag 1307341 cttataaagc acctgcaatc ttcgtggtgc aaaacaaccg ttacgcgatt tcaactcctg 1307401 ttgaaaaaca atctgcagct gaaacaattg cacaaaaagc tgtagctgcc ggtattgtcg 1307461 gcgtacaagt agacggaatg gatccgcttg ctgtatacgc agcaactgct gaagcacgcg 1307521 agcgcgcaat caacggcgaa ggtccaacac taattgaaac acttacattc cgttatggcc 1307581 cgcacacaat ggctggtgac gatcctacta aatatcgtac aaaagaaatc gaaaatgagt 1307641 gggaacaaaa agatccgctt gtacgtttcc gtgcgttcct tgaaaacaaa ggcttatggt 1307701 ctgaagaaga agaagcaaaa gtgattgagg atgcgaaaga agaaattaag caagcgatca 1307761 aaaaagctga tgctgaaccg aagcaaaaag taactgattt aatgaaaatc atgtacgaaa 1307821 aaatgcctca caaccttgag gagcaatttg aaatttatac acagaaggag tcgaagtaag 1307881 ccatggcgca aatgacaatg attcaagcaa tcacggatgc gttacgcaca gaactgaaaa 1307941 atgacgaaaa tgtcttagtt ttcggagaag acgttggtgt aaacggcggc gtattccgtg 1308001 cgacagaagg attgcaaaaa gaattcggtg aagaccgtgt gtttgacacg ccacttgctg 1308061 aatctggtat cggcggtctt gcccttggtt taggcttaaa cggcttccgt ccggtaatgg 1308121 aaatccaatt cttcggattt gtttatgaag taatggattc agtttctggc caaatggctc 1308181 gtatgcgcta ccgttctggc ggacgctgga cttcacctgt aacaattcgt tctccattcg 1308241 gcggcggtgt tcatactcct gaacttcacg ctgacagctt ggaaggtctt gttgcacaac 1308301 agcctggtat caaagttgtt attccatcaa ctccttacga tgccaaagga cttttaattt 1308361 ctgcgatcag agacaatgat cctgttgtct tcttagagca tatgaagctt taccgttctt 1308421 tccgtcagga agttcctgaa gaagaataca caattgagct tggaaaagct gacgtgaaac 1308481 gtgaaggtac tgatctttca atcatcactt acggcgcaat ggttcatgaa tcattaaaag 1308541 ctgctgatga gcttgaaaaa gacggcattt ctgctgaagt tgtcgacctt cgtacagtaa 1308601 gcccacttga tatcgataca attatcgcct ctgtagaaaa aacaggacgc gcgattgtcg 1308661 ttcaagaggc acaaaaacaa gccggtattg ctgcaaacgt agtagcagaa attaatgacc 1308721 gtgcgatcct gagcttggaa gcacctgtac ttcgcgttgc agcgccagat acagtatttc 1308781 ctttctctca agcggagagc gtatggcttc caaaccataa agacgttctt gaaacagcaa 1308841 gaaaagtgct tgaattttaa tcaaactgca taatcgagag ggaagatgaa cgttttccct 1308901 ctattatata tctgttttca atgcttacga tgtaaacttt aaaattgctt aatcaaacta 1308961 ggaggtcgag aactgtggca tttgaattta aacttccaga tatcggggaa ggtatccacg 1309021 aaggcgaaat cgtaaaatgg tttgtcaagc ctaacgacga ggtagacgaa gatgatgtac 1309081 tggctgaagt ccaaaatgat aaagcagtag tagaaattcc ttcacctgtt aaaggaaaag 1309141 tattagaatt aaaagttgaa gagggaacgg ttgcaactgt tggacaaacg attattacgt 1309201 ttgatgcacc tggttacgaa gatcttcaat ttaaaggcag cgacgagtct gacgatgcga 1309261 aaactgaagc acaagttcag tcaactgcag aagctggaca agacgttgcg aaagaagagc 1309321 aagctcaaga gcctgcaaaa gctactggcg caggacagca ggatcaagct gaagttgacc 1309381 cgaacaaacg cgtgatcgct atgccttccg tacgtaaata tgcacgtgaa aaaggtgtag 1309441 acatccgtaa ggttactggt tcaggcaaca acggacgtgt tgtaaaagaa gatatcgaca 1309501 gctttgtaaa cggaggagcg caagaagctg caccgcaaga aacagctgca ccacaagaaa 1309561 cagctgctaa accggctgct gcaccagctc cagagggcga attcccagaa acacgcgaaa 1309621 aaatgagcgg tatccgtaaa gcaattgcaa aagcgatggt taactctaaa cacactgctc 1309681 ctcacgtaac gttaatggac gaagtggacg taacaaacct tgttgcacat cgtaaacagt 1309741 tcaaacaggt tgctgctgat caaggaatca agctgactta cttgccttac gttgtaaaag 1309801 ctcttacatc tgcactgaaa aaattccctg ttttaaacac gtcaattgac gataaaacag 1309861 atgaagtcat ccaaaaacat tacttcaaca tcggtatcgc tgctgacact gaaaaaggct 1309921 tgcttgtacc ggttgtgaaa aatgcagatc gtaaatctgt ctttgaaatt tctgatgaaa 1309981 tcaatggcct tgcaacaaaa gctcgtgaag gcaagcttgc tccagctgaa atgaaaggcg 1310041 catcttgcac aattacaaac atcggttctg ccggcggaca atggttcact ccggttatca 1310101 accatccaga agttgcgatt cttggtatcg gacgcattgc agaaaaagcg attgttcgtg 1310161 atggcgaaat cgtagcagct ccagtcttag ctctttctct cagcttcgac caccgtatga 1310221 tcgacggagc aactgcgcaa aatgcattaa atcacatcaa gcgtttactg aacgatccac 1310281 aattaatttt aatggaggcg taatgttatg gtagtaggag atttccctat tgaaacagat 1310341 actcttgtaa ttggtgcggg acctggcggc tatgtagctg ccatccgcgc tgcacagctt 1310401 ggacaaaaag taacagtcgt tgaaaaagca actcttggag gcgtttgtct gaacgttgga 1310461 tgtatccctt caaaagcgct gatcaatgca ggtcaccgtt atgagaatgc aaaacattct 1310521 gatgacatgg gaatcactgc tgagaatgta acagttgatt tcacaaaagt tcaagaatgg 1310581 aaagcttctg ttgtcaacaa gcttactggc ggtgtagcag gtcttcttaa aggcaacaaa 1310641 gtagatgttg taaaaggtga agcttacttt gtagacagca attcagttcg tgttatggat 1310701 gagaactctg ctcaaacata cacgtttaaa aacgcaatca ttgctactgg ttctcgtcct 1310761 atcgaattgc caaacttcaa atatagtgag cgtgtcctga attcaactgg cgctttggct 1310821 cttaaagaaa ttcctaaaaa gctcgttgtt atcggcggcg gatacatcgg aactgaactt 1310881 ggaactgcgt atgctaactt cggtactgaa cttgttattc ttgaaggcgg agatgaaatt 1310941 cttcctggct tcgaaaaaca aatgagttct ctcgttacac gcagactgaa gaaaaaaggc 1311001 aacgttgaaa tccatacaaa cgcgatggct aaaggcgttg aagaaagacc agacggcgta 1311061 acagttactt tcgaagtaaa aggcgaagaa aaaactgttg atgctgatta cgtattgatt 1311121 acagtaggac gccgtccaaa cactgatgag cttggtcttg agcaagtcgg tatcgaaatg 1311181 acggaccgcg gtatcgtgaa aactgacaaa cagtgccgca caaacgtacc taacatttat 1311241 gcaatcggtg atatcatcga aggaccgccg cttgctcata aagcatctta cgaaggtaaa 1311301 atcgctgcag aagctatcgc tggagagcct gcagaaatcg attaccttgg tattcctgcg 1311361 gttgttttct ctgagcctga acttgcatca gttggttaca ctgaagcaca ggcgaaagaa 1311421 gaaggtcttg acattgttgc tgctaaattc ccatttgcag caaacggccg cgcgctttct 1311481 cttaacgaaa cagacggctt catgaagctg atcactcgta aagaggacgg tcttgtgatc 1311541 ggtgcgcaaa tcgccggagc aagtgcttct gatatgattt ctgaattaag cttagcgatt 1311601 gaaggcggca tgactgctga agatatcgca atgacaattc acgctcaccc aacattgggc 1311661 gaaatcacaa tggaagctgc tgaagtggca atcggaagtc cgattcacat cgtaaaataa 1311721 ttttcatatc aaaaacagcc ccgctttgag cgagggctgt ttttttattt tgacagcaca 1311781 tgctgtaatg gtttaatgat gtcttctttc tttttcacac atccctcgat tttcaccacg 1311841 acatggcgct gatcaacaac cataagggta gggacagttt caatctcatc ttcccagcct 1311901 tcttttttat catagacctt cattttatct atttgctcgg gataatcttt ttctaaatca 1311961 agcagtgcat cgtaataagg cgcttcctgg tctatttggt tctcatcaga aaaaaacagg 1312021 atttgtgtat gatgaatgtt gtcaatccgg ctttttttca tcggattgat ggtggaaagc 1312081 gtacagcccg ataaagcaaa tactattatc agcatgggga ataccgcgcg atatcgcatc 1312141 tatcttctcc tctgtataaa cagtagttaa ctagctttag tttatcacga gagacggctt 1312201 aatctgcttc ttgttaccta attgttatat aattgaaacc gtttttaaag tgagattaca 1312261 tattatatca atcgtttaaa atagcaacct ggggtatatt gaattttttg ctgcattctt 1312321 ggatgaaagt tcaagaaaac gtgcaattac attatgtgct gtggcatata tatcgagtaa 1312381 agcttctgta tgaagaagat attgtatgat ggaaaatgga aaaacaaggt gaatatgatg 1312441 atatgaaata aaatgtgtta tacagtttgt tgttgacatt ttaaatgtga catattaata 1312501 taataacaac aaaagaaatt aagcgttttc aaatttcaaa gaaatgggga ataagagatg 1312561 ggtacgattg tttgccaaga ttgcaacgaa gccattcatt actttgaaga tgagaaagtg 1312621 acaacattat atggaacttg ctgcggacaa tgtcaatgtc ctgttgatga agagtaaaaa 1312681 aaagcatgcg gcttaaagcc gcatgctttt tattttttat tgaattgctt tttgttcttt 1312741 gatgacccgg atcatatgta aagtcgagtc ctcaggtcct tgaacaggga ggcctgcgtc 1312801 aaggttttta aaaatgtagc tgatgttttc ttctgtaata atttctcctg ggatgaagat 1312861 tggaatacca ggcggatata ccatgacaaa ttcagcaata atccgtccgg atgcttcttt 1312921 taatgggatg acttccgtat ttgcatagaa agcatcacgc ggagtcattg ccaataaagg 1312981 tatttctgga agcagaacct cagtttgctg atgtgttaca tcttgttctg acatttgctg 1313041 tgcgatctca gttaaagcct ctacaagccg gtctgcatca ttttggctgt caccaggagt 1313101 gaaaatacac aaaatattgt acagatcaga aagctccacc tcaatattaa aggattcacg 1313161 aagccatttt tccacgtcat gtcctgtcag gccaagactt ttcacagaga taatcaattt 1313221 tgtcggatca tagctgtaag ctgctttcga cccaagaatc tcagaaccga cacaataaat 1313281 gccttcaatc tgattgaggc gatctctcgt ctgattggca agcttgagtg tttcctcagc 1313341 aagctggcgg ccttctgttg caaggcgttt tctggcaaca tccaaagaag cgagaagcaa 1313401 gtaagaagtt gacgtagttg tcagcatgct caggatggat tgcactctgt ctttagatac 1313461 aaggccttct ctcatgttta aaatagagct ttgtgtcagt gatccgccca gcttgtgtac 1313521 acttgtcgct gctatgtccg ctcctgcctg catagccgat agcggcaatt cgtcgtgaaa 1313581 atgaatgtga acgccgtgtg cttcatccac aagcactggc acatcaaacg aatgagcgag 1313641 ttctacgatg ctttttaagt cggctgcaac accgaaatat gtcgggttga tgacgagaag 1313701 cccttttgca tccggatgct cggtaagcgc ccgtttagca gattcaagtg taattccgtg 1313761 ggagatgccc aattcattgt caatttcagg atgaataaaa attggaaccg ctccggaaaa 1313821 tacaatagct gtcataattg atttatgaac atttcttgga ataataattt tatcaccagg 1313881 tccgcaaaca gccattacca ttgtcataat ggcgccgctt gttccttgaa cagaaaaaaa 1313941 tgtatgatcc gctccaaatg cttcagcagc cagatcttgt gcttgtttaa taatgccttt 1314001 tggcgcgtgc agatcgtcta atggttcaat attaatcaaa tctatgctta acgcgttttc 1314061 accgataaat tgtctgaatt ctgggtccat tcctgcccct tttttatggc cgggaatgtg 1314121 gaattgaaca ggctgtctgc ttgcatgctt tttcagtcct gtgtataagg gtgtttcatg 1314181 ttgcgacaat tgttttccca cctttgtaat catacctatg cataatagtg tgtattaaaa 1314241 tcagtttctc aaccgttttt tagacgtaaa acaaatgaat tatattatga acttgaaaga 1314301 atgtaaagct agacaaaatt gatagtattg tcctgtgttt gtttttgttg aataatatca 1314361 agatgagtca agtgtcatgt ggtggttcat tcaagagtta tgttttttac atatcaaggg 1314421 gaagatgaga tatttttgtt tcatcttgaa actttttgaa aagtccgctg tctaaccgaa 1314481 tgaggcctta ataagaagta aaggattgtt gttcgtgttg gagttattca gtcattatgt 1314541 attgcatttc gaacgttatt ttatattaag cagacaaagc accctgctga ttcaatggtc 1314601 aattgttgtt ctggcgggct tatatctttt ggtgcatcat cccaaaataa accggcagcg 1314661 cacaatgttc ttggcgggtg ttatattgcg gattgtgctg ctggcgggag tgtctgttga 1314721 acttattcac caggtgcaat caacaaactt caccagcgct tacttaagag aggacggaaa 1314781 agaactgctg ccgctgctgc attttttgtt atacggatat gtgctgctga cggcttttca 1314841 ctatatgctg atgccgcgtg atcatggcgg aaagggtaag ttttatacgt tcgaccttgc 1314901 tgttgtcagt ttgccgatcg tacaaatgat ttttagtttc ttttcgtatt ggaaggaata 1314961 cccggatggg atggagccga ttgcattcgt gtttctgttt ttcatcatca ctcttcccat 1315021 tgcgttgaat gtagtgtttt tcaagctgta ttggagaacg gataagatct tactaggctt 1315081 attttatacg ctgattatcg gactgcttgt cttgctgctt gcgccatatc ccaatcaaat 1315141 ctcaaaagat tatggtgcag taatgccata tacgatttat ttggcaatgg cgggattttt 1315201 gatgagctat catctgttcc aaaagtcagg aaaggtttat gtgcgtgtga ataagtgggt 1315261 gacgatggct gtcatggtgt tttttgtcct gctgttaaat ccgatatata acataggaac 1315321 ggctgctttc gctgtatcaa agccagcaaa tgtccatgat tcattcaatt ttgtcgggga 1315381 gcacatttca tcagaaaaag cggaacagat actaaagtca ttttttccta cggatgaaac 1315441 actttatttg cacgatacaa acatggatgt gcattatttc tactcatttg aaagcaaagg 1315501 ttacaaagct gaggtagatg aagtatcgca gctaattcgt aattatgaat acttacaaaa 1315561 agcacatggg aaaaagctaa cgaatcagga gtacaagcga aagtccatcg ctttccttga 1315621 gcgacacgga cgtgtgttac ataaggatca tatcgaaaca aaggtatctc aagaagacgg 1315681 ccagacagtc gtacgtattt acctgaaaaa tcaacttcat aaaaaagatc atgctgatga 1315741 tggcgcggta ttttattggg aaaaggaaac cttaatgggg tttagtgaag atccttcgat 1315801 ttatcagctt gactctcttc tgcatgttca tataacggaa caagacattc acgacaaagt 1315861 ggaacaaatg tttacagcgc tgaacatatc aaaacagcct tatcagatca ctgatattga 1315921 aagcgacagc ctgcttggaa gcatggtgag agttgaaaca aaagttggaa ttgttttgga 1315981 atttgagggc gaatcaggtt gtttacatag tctttcgctt ccgatgaaaa agaatatctc 1316041 aatggctaac agccggctgc agcatcagat attatcgatc ttcgatgctc gtggatcaga 1316101 aaagaagaaa aaaagcagtc agggtgacat ggtgatgtat actgattctt ctaaaacata 1316161 tgagtttgtt gaagctcaag gtcagctaaa cgtttatgta tacagcgata cacctgatca 1316221 gtcattcccc tatacgtatc gtaatggaac attggcttac gaaaaagtag cttctctata 1316281 tcaggatgtc atttacaaaa agcgtatgcg tccgattatc gttcaaagag gggatgaacg 1316341 gcattatgca tggctgatca ttattcagcc gtttggttca aatcgccatg atgcctatgt 1316401 agtggatgga gaaacacaag aggtgaaaag tctttatgaa tcataaagaa aaagagtctg 1316461 tttttgtaga cttatacgac ctgtataaag aaggagagct agaggatgaa tcaatggaat 1316521 ggatgaaaca gcatgaatcc ctatttcaaa agaatgcgga agacttaaag agtaaaactt 1316581 gtttaaagag aagtcccggt gctgaagaag aaagccaaat cagatatatg aaagtatacc 1316641 tgtcttccat gtatatctgt ttcattttat tggccatttg gatgacggtg tggttttatt 1316701 tttaatgaag catagggatt ccattgagga cttgtatcgg cagtattatc aagaaatttt 1316761 aaattattta ttcagaagga ctcatcatct tgaaacagcc aaggacttag cgcaggacac 1316821 gtttgtaaaa gctcttaacg gtctggcttc gtttaggggg cattcttcca tcagaacatg 1316881 gctctacacc attgcgcatc atacctttat caattggtac cgaagggatg tcaaatacca 1316941 atttactgaa atcagcaaaa atgaagggtt aacgcaaaca acttatgacc agcctgaaca 1317001 gtatctgtca cggacggtga aaagcgaaac actgcggcag gagctcctga agttaaaaga 1317061 tcagcatcaa tccgttttga ttttaagaga attccaagag ctttcttatg aagaaatcgc 1317121 tgagatatta ggatggagtc tttctaaggt gaataccaca ttgcaccggg ctagattaga 1317181 gctaaagaaa aacatgacga aaagtagaga ggaggagcgg atatgacctg ctttctagta 1317241 agagacctgc ttcctctgta tcttgaaggt gattgtaaaa gagaaacgga acacgttata 1317301 gaagagcatt taaaaatgtg cagcagctgc agagacatgt atgacacgat ggctgagcca 1317361 tttgaattgg aaagcgaaca ggccgttgag gaggcttatc tgccggaaga agaactgcgt 1317421 tttaaacaga ggtactatgg attactgatc atgaaagctg cctgctggtt tggagcggcg 1317481 gttgccatga tgctgatcat caaactgctg atataaaaaa agcgcttgtc cgattccggc 1317541 aagcgctttt ttacattaag cctggggatg aatcatatcg taaatagcgg caagctgttc 1317601 ttgtgacagg gcactgaaga gtttttcata aacgtcagct tgcagtggcg ttgcacctgc 1317661 ttgtagcgct gcgtctttat catagctgta cacatcatct tgtagcacaa tggctgcttg 1317721 aagaatgtga atcttgagag aaacagcgga gaaaaattgt tcaagtgcaa gtgcttcttt 1317781 ttctgtgaag ccaagttcaa ctgctttttc tgtatcaaat ttgtaatttc catcctcgag 1317841 atacacacat tgtgaaacaa tgctgaaaaa ttctgatgtc gattcccaga gtgtagcaat 1317901 tacctgagcc tcttcttttg tcattcctaa ctcgacagct ttttcgctgt caaaataata 1317961 tacaccgtct tgttcgtata tacattgatt taatatatca atgaatgtat tgagatcttc 1318021 gttagtgctc gcctgatgct ggagttgaac agcagtgtta tcaaccggtg tttttgcgct 1318081 ggctgcatca ggaccgaacg ttaatagagc agctgaggtc attgcggcag tcgttaacat 1318141 agcttttttt acaaatgttt tcttcatgtt tcttctctcc cttttatgaa ttgtgctaca 1318201 aattccatta tagggagtag tttccggtgg aggaataggc gctatggtat tttatgtgta 1318261 tcgttgccga actacttttt gaaggctgca cgtgtgatcg ttagaacgat tgtctatgta 1318321 tgaaggctgt tttgcatctt cctgactaag aaacagggga gataaggctt aaagaaatga 1318381 aaaacaccgc tttctttgcg gtgttttttg attacaatgt cgccggcggg gcaatgcttt 1318441 taatcaagca agccttgttc gcgcattttc ttttttaatg taaatccgcc gcccatgaca 1318501 gcgcaaacaa gtacaatgct ggcgataatg cctgcagggc ttttttcagc gataaagacg 1318561 ccgatcagca taatgctgaa aaccgctgca aatgcaaata atagtaaaag ccaattcatt 1318621 tttttcataa attccatccc cttttacgtc ttatattaag tttacagaaa aacgtgacgc 1318681 ttttaaagag gatgtgtgat ataatatgaa agttatctaa tttttttagg agatgaaaaa 1318741 gtgaaacttc gaaatgatct tcgcaacatc gcgattattg cccacgttga ccatgggaaa 1318801 acgactctag tcgatcagct tttacatcag gctggtacgt tccgtgccaa cgaacaggtt 1318861 gctgaacgcg caatggactc taatgatctt gaacgcgaac gcggcattac aatattggcg 1318921 aaaaatactg cgattaacta taaagataca cgtatcaata ttttggacac ccctggacat 1318981 gcagactttg ggggagaagt agaacggatt atgaaaatgg ttgacggcgt agtgcttgtc 1319041 gttgacgcat atgaaggctg tatgcctcaa actcgttttg ttctgaaaaa agctcttgag 1319101 caaaacctga accctgttgt tgttgtaaac aaaattgacc gtgactttgc tcgtccagag 1319161 gaagttatcg atgaagttct ggatctgttc attgagcttg atgccaatga agagcagctc 1319221 gagttcccag tggtatatgc ttccgcgatt aatggaacag cgagtcttga tccgaaacaa 1319281 caggatgaaa acatggaagc tttatatgaa accattatta agcatgttcc ggcacctgtt 1319341 gataatgcag aggagccgct tcaattccaa gttgcccttc ttgactacaa cgactatgta 1319401 ggccgtatcg gaatcggacg cgtattccgc ggcacaatga aagtcggaca gcaggtttct 1319461 cttatgaagc ttgacggaac ggcaaagtca ttccgtgtta caaagatttt tggtttccaa 1319521 ggcttaaagc gtgtggaaat tgaagaagca aaagcgggag acctcgttgc ggtttccggg 1319581 atggaagata tcaacgttgg tgaaacggta tgtcctgtag accatcaaga tccgcttccg 1319641 gtccttcgca ttgatgagcc gacacttcaa atgacatttg tcgtgaataa cagtccgttt 1319701 gcaggccgtg aaggcaaata tgtaacggcc cgcaaaatcg aagagcgtct tcaatcacag 1319761 cttcagacgg atgtgagctt gcgtgttgag ccaacagctt ctcctgatgc ttgggttgtt 1319821 tcaggacgcg gtgagctgca cttgtcaatt ttaattgaaa atatgcgtcg tgagggctat 1319881 gagcttcaag tgtcaaaacc tgaagttatt atcaaagaaa tcgacggcgt acgctgtgag 1319941 cctgttgaac gtgtgcaaat tgatgttcct gaagagcata ctggctctgt aatggaatca 1320001 atgggtgccc gcaaaggcga aatggttgat atgatcaaca acggaaacgg ccaagtccgt 1320061 ctcatcttta cagttccttc ccgcggattg atcggttact ctacagaatt cctatcatta 1320121 acacgcggat tcggtatttt gaaccatacg tttgacagct accagccgat gcaggcaggc 1320181 caagtcggcg gacgccgtca aggtgtactt gtgtcaatgg aaaacggaaa agcaacatca 1320241 tacggtattc aaggaattga agaccgcggt gtcatcttcg ttgagccggg tactgaagta 1320301 tacgaaggaa tgatcgttgg agagcataac cgtgacaacg accttgttgt taacgtcagc 1320361 aaaatgaaac agcaaacaaa cgtccgttct gcgacaaagg atcagacaac tacaattaaa 1320421 aaagcgcgca tcatgtctct tgaggagtct ctagagtact taaacgaaga tgaatattgt 1320481 gaagtaacac ctgaatccat ccgtttaaga aagaagatcc tcaataagaa cgaacgtgaa 1320541 aaagcagcta aaaagaaaaa aacagcagga ttgtcttaat ctcgtgcaga atttgaaaag 1320601 atagaacccg tacgtttaca ggggagggaa tctttttgaa tgacgtaagc gaacgcctgt 1320661 cgttcttcgc cgctctatat caagtagacc ggcagcctgc ggcaggcatg tggctgctgt 1320721 acggcacgat ttttgtgttg gccgttattg tatttaagct tggatttgct aaacggcttc 1320781 ctgtattaaa atctgcagtg gtgtatgtat ttttggcttt gggctgcact gttttgactt 1320841 ttttaggggt gtttttgccc gtggcagaag gattggtcgt cgctgcgctg attttaatca 1320901 tttacaaaat ccggctgtat cagtcgaaaa aaggacagtc tgcaaaatca taaaagactc 1320961 agctgaaagc tgagtctttt ttgtgttctg tatggttaag cggccgcttt attttttgac 1321021 tttttctttt ttctgctgtc ccgggtgaaa agtaaatttt cccgttttca gccgttcctc 1321081 tgtttttttg gcaatccgat cgtggcattc ctggcacata tatgtatgga tcgggcggtt 1321141 tcgaagccgt ttcgcgatca gggtatcatc atcaattgtt tcaattttat cgcaaataga 1321201 acatttgacc ctcatcatat cacctctttc actaacatgt attataccac ggatcagaag 1321261 ctgtccaaaa taagaaaaag ctaaagcgca aggctatagc ttagtcattg ttgttctttt 1321321 tcatatgatg atcagattga tcgttttgtt ccttctccat ttcctgttgc tgttttctat 1321381 ttaattggtc attttgctgc tttgtttgcg gttcatcttc attgtcaatc acatcgttag 1321441 gcacttcggg aagcactcgg ccgacaattg cagctaattc atccagtata cctgttaccg 1321501 gatggccctc gctgatttct ctgctcattt cgcgaaggcg gctgaccgta tcgggatcag 1321561 caatgactac tgcgttggcg ccatatcgat cattctttag cgcctgagct acagaatatt 1321621 taatggtttc cactttgctt ctgtccaaag tatcatcgac atcaatccca acaacagcat 1321681 agcctcccag cacaacggct gttgcatcct tgacgtcggg gtttttttca gcaacgctga 1321741 caagatgctt ggcaatatcc gttcttgttc cattgtcttt tgtttcttga gttgtgtcct 1321801 ttacgtgaat cggtttagtc tcctgctgtc ttgttgattc tttttcaaca ttctggccct 1321861 gttttccttg ttgataggca caagcggaca ggataagtgt cagctgtatg ataatgaaaa 1321921 gaattcgcac ttgcgggttc cctccttaaa atgctttcat taattttatt gttgaattaa 1321981 ccttctatct ttatgcacaa aaacatatat tttagcaggc attcaccttt ttcatcaaaa 1322041 gagaagcagg aagaactttg acccttatat caggaggctg agacttgagt aaaatttatg 1322101 tgttagatac gaatgtgtta ttacaggatc ctaacgcgat attttctttt gaagaaaatg 1322161 aggttgtcat ccctgctgtc gttttagaag aggttgattc aaaaaaacgg tatatggacg 1322221 aagttgggag gaatgcaagg cacgtatcta agctaatcga tgcgctaaga caaaagggca 1322281 ggctgcatga gcatgtaccg cttgacaccg gcggcacact gagaattgaa ctgaatcatc 1322341 gttcgtttca ccagctgcaa gagatcttta ttgaaaagac gaacgataat cgcatattag 1322401 ccgttgcgaa aaacttaagc ctcgaggaag aaaccaagga aaatggcagg ccggttatcc 1322461 ttgtcagtaa ggatgtactg gtcagggtta aagccgacgc aatcggactg cttgctgaag 1322521 atttcttgaa tgaccgggtt gtggacaatg atgaaatgta cagcggctat aaagatttat 1322581 atatcagcca gcagctgttc agctcttttt acgggaaaaa tcaaatttca gtaaacgatg 1322641 tgaaacagca tgcgttttat ccgaatcagt ttgctttaat gaaggatgag ctaggagggt 1322701 cctcctcggc agtcggaatt gcagacaaaa ccggaacggt attaaaaaga ctcgtatttg 1322761 atgatgaaca tatatgggga atcaggccga aaaatgtaca gcagacaatg gcattagagc 1322821 ttttgctgcg ggaagatatt ccgcttgtca ccctgatcgg caaagcggga accggcaaaa 1322881 cgctcttagc tttggcggca gggctattac agacagaaga cttgggaata tataaaaagc 1322941 tggtcgtcgc aaggccgatt gttcctgttg gcaaggacat cgggtatttg ccaggcgaaa 1323001 aagaggaaaa gctaaagcct tggatgcagc cgatttttga caacttagag tttctgttta 1323061 atgcgaaaaa accaggggag cttgatgcta ttttggcggg aattggctca attcaggtag 1323121 aggcgctgac ttatatcaga gggagaagca ttccagatca atttattatc attgatgaag 1323181 cgcaaaattt gaccaggcat gaggtgaaaa cgttgctgac gagagtcggt gagggcagta 1323241 aaattgtctt aatgggcgac cctgaacaaa ttgatcaccc atatttagac agtctgaaca 1323301 atggtttggc ctatgtggtt gagcggttta aaggacaacc catctcaggc agcgtgaagc 1323361 tgttaaaagg tgagagatca ggtctcgccc agcttgcagc tgatttgctg taacacttaa 1323421 atgatttcga tctcttttac atcggtaatc ggctgtttgt gatgaaccgg gtcttcaaag 1323481 taaatatgca cggggccgcc ttcttgaatc ggcttgcctg cctcactgaa atggacaata 1323541 ctgttcagag cggtttccag agaaacggcg gcctttcccg aacttgtgac aaatacacat 1323601 tgtgtcgcag agctgttcgg ctcagcattt ttcaggacag tcccaagtct cattgcgaaa 1323661 ctgccgttca tcagtttttg cttctcatat tgcttttccg tctttaatgt aggcggcgcg 1323721 attcgcccct ctctgatgac gcgttccgga tcaaggtcgg attcatcccc ggctgattgt 1323781 aaatatgtgt cttgactgtc ccctttgcgg tcaaacgaaa atttgcgatc atcaaaaatc 1323841 catacgcttg gatcaatggt aattggatat gtaacattgc cttttacttg gataacgctc 1323901 atgatatgac ccccttctct caaaattata aaagttttcg catgaattgt cactttgtgt 1323961 acaaattatg tgtattgaaa tgctgaggga acgagggtgt ttgcatggta tgccagcata 1324021 atgatgagct tgaagcctta gtgaaaaagg cgaaaaaagt aacggacaag ggggaggtag 1324081 ccagctatat tcccgccttg gcaaaagctg ataaacacga cctgtcagtg gcgatttatt 1324141 attccaataa tgtttgtctg tcagcaggtg acgtagaaaa aacatttacg cttcaaagta 1324201 tatcgaaagt cctttccctt gctttggtgt taatggaata cggcaaagat aaggtcttca 1324261 gttatgttgg acaggagccg accggtgatc cgtttaattc aattatcaag ctcgaaacag 1324321 tgaatccgag caagccgtta aaccctatga ttaatgccgg ggcattggta gtgacaagtc 1324381 tgataagggg aagaacggta aaagagagac ttgattattt gctttctttt atcagaaggc 1324441 tgacaaacaa ccaagagatt acatactgcc gggaagtggc tgaatctgaa tacagcactt 1324501 caatgattaa tcgggcgatg tgttattata tgaagcagta cggcattttt gaagatgatg 1324561 tagaggcagt aatggattta tatacgaagc aatgcgcgat tgagatgaac agcttggatt 1324621 tagcgaaaat cggatctgta ttcgcattga acggcagaca tccagagact ggggagcagg 1324681 tcatctcaaa agatgtcgct agaatttgca aaacgtttat ggtgacgtgc ggaatgtaca 1324741 atgcaagcgg ggaattcgca attaaggtcg gaattcctgc gaaaagcggc gtatccggcg 1324801 ggataatggg catttcgcct tacgatttcg ggatcggcat attcggcccc gcattagacg 1324861 aaaaagggaa cagcattgca ggtgtaaagc ttttggaaat aatgtctgag atgtacaggc 1324921 tgagtatttt ttaatttatg tcatatgctt aaatcctctt gcattttctg ttgataccct 1324981 ttatgataaa tagaagaatt aggtactcgc ctggggaacg gagggatact tttggcttca 1325041 gagatgatag ttgaccatcg gcaaaaagct tttgaactct taaaagtgga cgctgagaag 1325101 attttgaagc tgatccgagt acaaatggat aacttaacga tgcctcaatg tcctctatat 1325161 gaagaggttt tagatactca aatgttcggg ctttcgaggg aaatcgattt tgctgtccgc 1325221 ctgggattgg ttgatgaaaa agacggtaaa gaccttttat acacattgga gcgcgaattg 1325281 tctgctttgc atgacgcgtt tacagctaaa taaatgataa aactcaaact tattaacagt 1325341 ttgggttttt ttataaccgc tatttttctc tcatctcata aaagacggtc tttttttaca 1325401 cattccttcc gaatcgtata gagattcttc gtctcgtttg ataaattgta gtaaaataaa 1325461 aaagataaat acataaaaac catagataat ggaagttaga agcagggaag aggatgttat 1325521 gttaaaaaaa atgctaaaat cttatgatta ctcactgata ttcgcaatcg ttttattatg 1325581 cggattcggt ttagtgatgg tatacagctc aagcatgatt acggctgtct cccggtatgg 1325641 agtaagcagt aattttttct tcatgcggca gctgtttgct ttaattgcgg gtggcgctct 1325701 atttattctc atggcgttgt ttccttataa agcactggcc catcaaaagt ttcagaaggg 1325761 gatactgctt gtatctgttc ttgcgcttat ctcactgttt gttttcgggc atgttgccgg 1325821 aaacgcgcag agctggttta aaatcggcgg aatgagtatt cagccggggg agtttgtgaa 1325881 actggtcgtg attttatacc ttgcagccgt atatgcaaaa aaacaaagtt atatcgacca 1325941 tctgttaacg ggagtagccc ctccggtagt catgacgctt ataatttgtg ggttaattgc 1326001 catgcagcca gatttcggta cagccatgat tatagggtta attgcgacgt gcatgatctt 1326061 gtgctccggc ttcagcggaa agacgctggt gaggcttgtg atactgggcg gaattgtttt 1326121 cattttagtc agccctatta tctatttgaa tcaggacaaa attttaactg aaggccgttt 1326181 agcgcgtttt gagagtcttg aagacccatt taagtatgca aattcatcag gtttgcaagt 1326241 gatcaattct tattatgcga tcagctcagg cggcattttc ggcctggggc tcggtgaaag 1326301 tatccaaaaa tacggatatc tgcctgaatc acacactgac tttattatgg ctgtcattgc 1326361 tgaagagctc ggcatttttg gggtattgtt tgtgattttc ttattgggtt ttgtcgtcat 1326421 aaaaggtttt tatattgcca gaaaatgcga ggacccgttt ggaagtcttc tggcgatcgg 1326481 catttcaagc atgattgcca tccagtcgtt tattaacctt ggcggtgtca gcggattaat 1326541 tccgattaca ggggttacgc tgccatttat cagttacggg ggctcttctt tggtgctgct 1326601 gctggggagt atggggatat tagcgaatat cagcatgttt gtgaaatatt cagagaataa 1326661 gaaaaagaaa gagcccttgg cgccgaaggg aatgaaaaag aaacagctca aaaaaactgt 1326721 ttatctgtaa aaaacaagtg tgtacagggg aaggatattc cgctatgata gattatattc 1326781 cattcgggta agggggagaa aagtttgtct cagcaatcga tacaaaaagt attagtagca 1326841 aacaggggag aaattgcaat ccgaatattc cgggcgtgta ccgagttgaa tattcgtaca 1326901 gttgcggtct attcaaaaga agattccggt tcctaccatc ggtacaaagc ggatgaagca 1326961 tacttggtcg gtgaagggaa aaaaccgatt gatgcttacc tggatattga aggtatcatt 1327021 gatattgcga aaagaaacaa agtcgatgca attcatccgg gatacggttt cttatctgaa 1327081 aatattcatt ttgcgagacg atgtgaagaa gaaggcatcg tattcatagg gccaaaatcc 1327141 gagcatctcg atatgtttgg tgacaaggta aaagcgcgtg agcaggcaga aaaagcggga 1327201 atccccgtga ttccgggaag cgacggtcct gccgaaacgc ttgaagccgt cgaacaattt 1327261 ggacaagcta acggttatcc gatcatcatt aaagcctcgc ttggcggcgg cggccgcggt 1327321 atgcggattg tcagatctga aagtgaagtt aaagaagcat atgagcgtgc taaatcagag 1327381 gcgaaagcag cctttggcaa tgatgaagtt tatgtagaaa aattaattga gaatccgaaa 1327441 catattgagg ttcaggtcat tggagacaag cagggcaatg tcgtccatct ttttgagagg 1327501 gattgctccg ttcaaagacg ccatcaaaaa gtcattgaag tggcgccgag tgtctcgctg 1327561 tcacctgaat taagggacca aatttgtgag gctgcagttg cgcttgccaa aaatgtaaac 1327621 tatataaatg cggggacggt cgaattcctt gttgcaaaca acgagttcta ctttattgaa 1327681 gtaaatcctc gcgtacaagt tgaacacacg ataacagaaa tgattactgg tgtcgatatt 1327741 gttcaaactc agatccttgt tgcccaaggg cacagccttc acagcaaaaa agtaaatatt 1327801 cctgagcaaa aggacatttt tacaatcggc tatgccattc agtcacgggt tacgactgag 1327861 gatccgcaaa atgatttcat gcctgataca ggaaaaatca tggcttaccg ctcaggcggc 1327921 ggttttggtg tccgtcttga taccggaaac agcttccagg gcgccgtgat cacaccatac 1327981 tatgattcac ttctcgttaa gctttcaact tgggctttaa cgtttgaaca ggcagctgcc 1328041 aaaatggtgc gaaaccttca ggagtttaga atcagaggca taaaaacgaa cattccgttc 1328101 cttgagaacg ttgcaaagca tgagaagttc ctgacagggc aatatgatac atctttcatt 1328161 gatacaacgc ctgaattatt taatttccct aaacaaaaag accgcggaac gaaaatgctc 1328221 acttacatcg gcaatgtgac agtgaacggc ttccctggaa tcgggaaaaa agaaaaaccg 1328281 gcgtttgaca aaccgttagg cgtaaaggta gacgttgatc agcagcctgc cagaggaaca 1328341 aagcaaattc tcgatgaaaa aggtgcagaa gggcttgcaa attgggttaa ggagcagaaa 1328401 tctgtccttt taactgatac gacattcagg gatgcccacc aatcgttatt ggcaactaga 1328461 atcagatcgc atgatttgaa aaaaatcgca aatccgacgg ctgcgttatg gcctgaacta 1328521 ttcagtatgg aaatgtgggg aggcgcgacc ttcgatgtag cctaccgatt cctgaaagaa 1328581 gatccgtgga aacgtttgga agatcttcgc aaagaagtgc cgaatacctt attccagatg 1328641 ttgcttcgct catcaaatgc ggtcggctat acgaattatc cggacaatgt gattaaagaa 1328701 tttgtgaagc aatcagctca atccggtatt gatgtgtttc gtattttcga cagcttaaac 1328761 tgggtaaaag ggatgacgtt agccattgat gctgttaggg ataccggcaa agtggcagaa 1328821 gctgcgattt gttatacggg agatatcctt gacaagaacc ggacgaagta cgaccttgca 1328881 tattatacat cgatggcgaa ggagcttgag gcggccggag cccatattct cgggattaaa 1328941 gatatggcag ggctgttaaa accgcaggct gcatatgagc tcgtttctgc gttgaaagaa 1329001 acgatcgaca ttccggttca ccttcatacg catgatacga gcggaaacgg tatttatatg 1329061 tatgcgaaag ctgttgaagc cggcgttgat atcatagacg tggcggtcag ctcaatggcg 1329121 ggattaacgt cacagcctag cgcgagcgga ttttatcatg cgatggaagg caacgaccgc 1329181 cgtccggaaa tgaatgtcca aggcgttgaa ttgctgtccc aatattggga gtcggtgcgt 1329241 aaatattata gtgaatttga aagcggaatg aagtctccgc atactgaaat ttatgaacac 1329301 gaaatgccag ggggccaata cagcaacctg cagcagcaag ccaagggagt aggccttggc 1329361 gaccgctgga acgaagtcaa ggaaatgtac agacgcgtga acgatatgtt cggtgacatc 1329421 gtcaaggtaa cgccttcctc aaaagtagtc ggagatatgg cactctacat ggtgcaaaac 1329481 aatctgactg aaaaagacgt ttacgaaaaa ggtgaatctt tagatttccc tgattctgtc 1329541 gtggagcttt ttaaaggaaa tatcggccag cctcatggcg gattcccaga aaaactgcaa 1329601 aagctgatct taaaagggca ggagccgatt acagtcagac cgggcgaact gcttgagccg 1329661 gtgtcatttg aagcgatcaa acaggaattt aaagagcagc ataacttgga aatttcagat 1329721 caggatgctg tggcatatgc cctttatcct aaagtcttca ctgattatgt gaaaacgaca 1329781 gaaagctatg gagacatctc ggtattagat acaccgacat tcttctacgg tatgacatta 1329841 ggtgaagaga tagaagttga aattgagcgc ggcaaaacgc tgatcgttaa gctgatttca 1329901 atcggtgagc ctcagcctga tgccacccgc gtcgtttatt tcgaactcaa cgggcagccg 1329961 cgtgaagtag tcattaaaga tgaaagcatt aagtcttccg ttcaggaaag gctgaaagca 1330021 gaccggacaa atccaagcca catcgcagct tccatgcctg gaacagttat taaggtattg 1330081 gctgaagcag gcacaaaagt caataaaggt gatcatttga tgattaatga agcgatgaaa 1330141 atggaaacaa cggttcaggc gcctttctca ggaacaatca agcaggttca tgtgaaaaat 1330201 ggtgagccga tccaaacggg agatctgctc cttgaaattg aaaaagcata aaaaacaaag 1330261 agtgtatatc aatgatatac actcttgttt tttatataga aaatgtggag tgaaacagat 1330321 ggttagaaga gatataaggg gacttcagag attatagagt actgtcacaa gcccaaaata 1330381 aaaagaggct tatacagcca atattttaga tgctttgtag tatgccgtgc atatttcttt 1330441 aagcactatc tgatttaaaa ggctttaata cttatgttcg cgagctatag atccatatga 1330501 aatttctata atcacgatga gaaaggggac agaccgaagt gagccgctca ctgatcatca 1330561 agttcggcga aggctggcga ttgaaacgca taaagcgcca aaaaacaaga cataaaaaag 1330621 accaaagccg cctaaggctt tggtcttgag tccttatgat tgcctggatt cataacggaa 1330681 acgagcaatc aataataaga agtagcatag aacgccaaac agacaggcaa taaagaacga 1330741 gtgggcaagt gcaaagccca gagccagttc agagtatacg atcataatac cggacagtgc 1330801 ctgtaatgta atgaaaataa gacatgagat ccatccccaa aagatctgtt tttgatcttt 1330861 ataggaagta atagcatgaa cagcggcaac aataatccat acaaataaaa gtaaggctgc 1330921 tgctctgtgg cccatttgca cccattcatg gaattgggtc ggaagtccat tgttcagcgg 1330981 gctgcacagc ggcacattag gacatgccag acttgattca gtgtgtctta catatgcgcc 1331041 tgtatacaca acgatatagg aatatattaa aattcctatc atgtgaaatt gcatcttttt 1331101 gccgatttga agcggcttaa ccagtgttct gactgattta tcagcttcaa atatgagcaa 1331161 tgttaaaata agcactgaag caaaagaaat taatgagatg ccgaagtgaa gcgccataat 1331221 cagcgcgttc gaaccgaata cgacagccaa tgcgccaagc aatgcctgaa gaaataaaaa 1331281 gataattgac atgatcgcga gaaacgttgt ttcacgaaaa atcggcgtga tttttctcca 1331341 tgaccaaaac gcaaggctta gcacaaggat aatagagatt ccgcttgcga atcggtggct 1331401 ccattcaata attgaagccg gattcagttc agggaaaaaa cggccgtgac acagcggcca 1331461 ctgtctgccg catccttggc cggaacctgt ttttgtaacg agggcacccc cgattaaaac 1331521 aattagcatg acaaatgtcg tcagaacacc gagagctttt aatgctttat tcatacaata 1331581 ttcaccttct taacatactg ctgcaatttt atatacgttc caagtgtaag cgaatatgtg 1331641 ttttgtggca attcccagag ccttttgttc acaaaaatat aatagaatga cggcttctgg 1331701 aaaatgtaca cttgattatt catgccgggt ctgatagaaa taaggtaaac gcaatgccga 1331761 tttggagatt gccttcatct ttggtaaaat tcataaaaag ttcacaaata aattcctgtt 1331821 tgtcgtttaa tatttaatag gatgtttttt tacaagatgt tatcttgtat gatagagttg 1331881 caggttattt tattctcctg cgttaggttt gtaagggagg tttacgttat ggctaactcc 1331941 agaatcttaa atgatacagc tatagacgga caaattgaag aaacaacggc atggaaagat 1332001 tttctgtccc ttattaaaat agggatcgtc aattctaacc tcatcacgac tttcactgga 1332061 atgtggcttg cactgcatat atccggttta agttttttag gcaatataaa caccgttctt 1332121 cttacgttaa tcgggtcttc actgattatt gcgggctcct gcgcgatcaa taactggtat 1332181 gaccgggaca ttgaccatct tatggagcgt acgaaagtaa gaccgacggt tacgggtaaa 1332241 attcagccga gtcaggcgtt atggtctgga attttgctgg ttgctttagg attgatcatg 1332301 ctgctgatga caactgtcat ggctgctgtt atcggtttta tcggagtctt tacgtatgtt 1332361 gtattgtaca caatgtggac gaaacgccgc tatacgatta acacagtagt aggaagcgtt 1332421 tccggtgcag tgccgccgct tattggatgg acggcagtgg aagggaatat cggtgtcgta 1332481 gcatgggtgt tattcatgat tttatttatt tggcagattc ctcacttctt agcattggct 1332541 attaagaaaa ctgaggatta cagagctgca aatattccga tgcttcctgt cgtatacgga 1332601 tttgaagtga caaaaagaca aattattgtg tgggttgcgt gcctgatgcc gcttccgttt 1332661 ttccttggta gcctgggtct tccgattgtc attctcggct tgctgttaaa tatcggctgg 1332721 ctgattcttg gcttaatggg attccgctcc aagaatatca tgaagtgggc aacgcagatg 1332781 ttcgtttact cgcttaacta catgacaatc tatttcgttg ccatggttgt cttgacgctt 1332841 ttctaaaaaa tagatatgat gcttgtttta tcgcttcaaa ataaacgatg acaactagta 1332901 aatgccgcct tgacctcttg tttaatcagg cggctttact tttatacata gatggcattt 1332961 tgagtaaaaa aactcataat ttaagagaag aggaaatgta agtgctttat tggtgatagg 1333021 ttggatggcg atagatttcg atccgctttc cgcctttgta ttgaccagaa aaggggttgg 1333081 gtgaaatggt aaagcattgg cgtcttattt tattattagc cttagtgccg cttctattaa 1333141 gcggatgtgg aaaacctttt ttatccacgc tcaagcctgc tggcgaggtg gctgataaac 1333201 agtatgacct gacagtgctc agcacattga ttatggtggt tgttgttgca gtagtatctg 1333261 ttatcttctt ttatgtgatt gtgagattca gaagatcacg ggtcggtgag aacacgatac 1333321 cgaaacaggt agaggggaat aaatttttag aaatcacatg gaccgtgatc ccgattttgc 1333381 tgctcattat tcttgtgatt cctgttgtat tatatacgct ggagctagcg gacacatcac 1333441 caatggataa aaaaggccgc aaagctgagg atgctcttgt agtcaatgtt agggcaaatt 1333501 tatactggtg ggagtttgag taccctgatt acggcattat cacaagccag gagctgattg 1333561 taccgacaga tcagcgtgta tattttaatt taaaagcctc tgatgtaaaa cattccttct 1333621 ggattccttc agttggagga aaacttgata cgaatacgga taatgaaaat aagttcttcc 1333681 tgacatttga ttcaaaacga agcaaagagg caggagatat gttttttggg aagtgtgcag 1333741 agctttgcgg cccttcacat gcgctgatgg attttaaggt gaagacgatg tctgcaaaag 1333801 aatttcaggg ctggacaaaa gaaatgaaga actataagtc tacagcagag agcgatttgg 1333861 ctaagcaggg tgaagaactg tttaaagaga aaaactgcct gagctgccat gcggtagagc 1333921 cgaatgataa gcgtgcagaa gccgctagaa cggcacctaa cttggcgacc ttcggtgaaa 1333981 ggacaaaagt ggcaggggtg aaagaggcca acaaagaaaa tgtgaaggct tggctgaagg 1334041 accctgacag cataaagccg gggaacaaaa tgacaggcac atatccaaag ctctcagaca 1334101 gcgaaacaaa tgcgctttat gaatacttaa aaggcttaaa agcggaaagc aagtagggaa 1334161 gaaagggaga tattggggga ggtcacatat gttgaatgcg cttacagaaa agcggacgcg 1334221 cggatctatg ctttgggatt atttgacgac ggtggaccat aaaaaaatcg caattcttta 1334281 tttagtggca gggggattct tctttcttgt cgggggaatt gaagcgatgt ttatcagaat 1334341 tcagcttgca aagccggaaa atgcgtttct cagtgctcaa gcgtacaatg aagtaatgac 1334401 tatgcacgga acgacgatga tctttctggc tgcgatgccg ctcttatttg ccttgatgaa 1334461 tgcggttgtg cctttgcaga tcggggctcg ggacgtttcg tttccatttt taaacgcgct 1334521 tggtttttgg ctcttctttt tcgggggcat tttcttaaat ctaagctggt ttttgggcgg 1334581 agcgccagat gcgggctgga catcatatgc ctcactttcg cttcattcta aagggcacgg 1334641 catagacttt ttcgtcctcg gactccaaat atcggggctc gggacgctga tagccgggat 1334701 taactttttg gccacgatta tcaacatgag ggctccgggc atgacgtata tgaggctgcc 1334761 tttgtttaca tggacgacat ttgtggcctc ggcattgatt ttgttcgcgt ttccgccgct 1334821 tacggttgga ttggctctca tgatgctgga tcggctgttc ggaaccaatt tctttaatcc 1334881 ggagcttggc ggaaatacgg tcatttggga acatttattt tggatcttcg gccacccgga 1334941 ggtttatatc ctaattttgc ctgcattcgg tattttttct gaggtcatcc ctgtgttcgc 1335001 cagaaagcgt ttgtttggct attcttcaat ggtttttgca atcgtgctca ttggctttct 1335061 gggctttatg gtttgggtgc accacatgtt cacgactggt ctcggcccga ttgcaaatgc 1335121 gatttttgcg gttgcaacaa tggctatcgc gattccgacc gggattaaga tttttaactg 1335181 gctgttgacg atttggggag gaaatgtgaa gtatacaacc gctatgctgt atgctgtctc 1335241 atttattcca tcctttgtgc tcggcggtgt gacgggagtc atgctggcag ctgctgcggc 1335301 tgattatcag tttcatgata cgtattttgt ggttgcgcac ttccactacg tcattattgg 1335361 cggcgttgta ttcggccttt tagccggtgt tcatttctgg tggccgaaaa tgttcggtaa 1335421 aattctgcat gaaacgatgg ggaaaatttc atttgtattg ttttttatcg gctttcacct 1335481 cacgtttttc attcagcatt ttgtcggctt aatggggatg ccgcgccggg tttatacgtt 1335541 tttgccagga cagggtctgg aaaccggcaa cttgatcagt acaatcgggg cgttttttat 1335601 ggcggcagct gttattcttc tgctggtcaa tgtcatatgg acatcggtaa aaggtgaata 1335661 tgtaggtgct gatccatggc atgacggacg tacgctggaa tggaccgttt cttcaccgcc 1335721 gccggagtat aactttaaac agcttccttt tgtcagagga cttgatccgc tttggatcga 1335781 gaagcaggca gggcacaaat caatgacgcc ggcggaaccg gttgatgata ttcatatgcc 1335841 aaacggctca atcctgccgc tcatcatttc cttcggcctt tttgtcgcag cgttcgggct 1335901 gctgtacaga agtgattacg cttggggcct gccggtgatc tttatcgggc tcggcatcac 1335961 atttattacg atgctgcttc gttcagtaat tgatgatcac ggctatcata ttcataaaga 1336021 ggaactgccg aacgatgata aaggggtgaa ggcataatgc aagttcaaga aaaattcacc 1336081 gcagaaacct ttccagcttc tcctgaaaaa gtaaccctgg aagggaaaaa taaattttta 1336141 ggcttttggc tttttcttgg cggagagact gttctgtttg cgtctctctt cgccacgttt 1336201 cttgcgcttc ggaattcaaa tgccggtgat ccgcctacga cggaaatgtt cgatgtgaca 1336261 cttgtattca ttgccacaat gcttctatta acgagcagtt taacgagtgt gtacgcgatg 1336321 taccacatga agaacttttc cttcggcaag atgcagcttt ggctgggaat tacgatttta 1336381 ttgggggcgg gctttttagg actggaaatc tatgagttca agcattacac ccatgaattt 1336441 ggctttacca tcacaagctc tgcccttggt tctgcgtttt acacgcttgt cggtacacac 1336501 ggcgcccacg tggcatttgg gcttatgtgg atcagcacgc ttatgatccg caatgccaag 1336561 agagggctga atctgtatac ggcgcctaag ttttacgttg ccagccttta ttggcacttt 1336621 attgatgtcg tgtgggtctt catctttacc gttgtatatt taatggggat ggtgggataa 1336681 acatggtcga taaaaaaagc agagggcata tcaatagcga ccttgaattt aagaaaaaaa 1336741 agcatgcccg ggagatgaaa tatcaagtcc tgtcttttgg tttaatgatc ggtcttacga 1336801 ttgttgcatt tctgactgtg gccacggacg gtgtcggcag ctggtttacg attcctttca 1336861 ttattttgct agctgcaatt caagtcattt ttcagctgta ttatttcatg catatgaatc 1336921 agaaagggca tgaggcgccg gcactgtttt tgtattcagg ggtgtttgtc gcgtttatca 1336981 ctgtgcttgc gtttgtgaca attatatggt ggtaatttga acagccgccg gaggtgaaga 1337041 aatgaatcag ttggagatat ttgggtttcg cgcgatgtgg agcccttatc ttttttgtat 1337101 cctgttaggc attacggcgc tttatctcta tttttacagg cgaatgtctt caaagccgaa 1337161 tcgaataact ggtaaagaga tggtgtgctt tctgtcggcg atgctgtttt tatatgcagc 1337221 cgagggaagc ccggttgatc tgctcggaca tattatgttc agtgcgcata tggtgcagat 1337281 ggccgtcctg tatttggttg tcccgccgct gttaatcgcg gggattcctg catggctctg 1337341 ggaaaaaatc attttcaggc cttcaatcaa accggttttt tcctttttta cgacgccttt 1337401 aattgctttg cttttgttta acggcatttt ttctttatat catgtaccgc ttatatttga 1337461 tactgtcaaa acagatccgt tttaccatac attaatcact tggcttatct ttgtgcttgc 1337521 gttcttcatg tggtggccgc ttgttcataa ggttgagcgt ctacggcagc tcagcggctt 1337581 gatgaagctg ggttatatta tggcggacgg tatgctgctc acacctgctt gcgccttgat 1337641 catgttcagc ggtgcaccgt tatacgccac ctatacagat ccggctttat gggctgaggc 1337701 aatgaggctt tgcgtgccag cggatatgat ggggcaggtc ccattaacag ggccagagat 1337761 gttgaataca ctgcctttgt tagaggatca gcagctcgga gcagtcatga tgaaaatcat 1337821 tcaggaaatt gtgtacggta cttttttggc cgttattttt ttccaatggg tgaagaaaga 1337881 aagggaaaag gacgggcagg aggagccgcc gtatattcag cagacgatat cataaaaggt 1337941 acagcgaaat atgctgtacc ttttcgttac atttgaactg tttttaacat gttggctatg 1338001 tcctgaatca gtgccttgct ttttgtcaca acctgtacgg gaaactcttc cgtttctcca 1338061 tattctactc catgagggta gtaatgcttt cctaggagag gggacattaa ttgaatcacg 1338121 gcgcgcccgc ttccgacatc gccttctgcc gcaatacctt gtatccgcag gtaaaacgta 1338181 ccctcaatcg tcgaaaactt cttgtcatag gtgactctct cgtaatccca ttgacccgct 1338241 ctgataagac ctttgctttc cattaagtcg tctagccagc tgagctcagc cttaacccct 1338301 tcaagtccgc tttcagtaaa cttcaacact gacccctcct tataaaaatt acctttcctg 1338361 acaatcatag tatgaaagcg ttaaactttc aatgaatctt cttcttttga aagtatgcaa 1338421 aaattaaatt ttgacgacaa tagcactaga ctaaaggagg ttaaacggat gacaaaaata 1338481 aaagatctga tgacagccga cttgcaatat tgcacggtat tagataatgt atatgaagct 1338541 gcagtaaaga tgaaggacgc aaatgtagga gcgataccgg tagttgatga ggacggggaa 1338601 acattggtcg gcatcgtaac cgaccgcgat ctcgtattaa gaggaatcgc catcaaaaaa 1338661 ccgaactcgc aaaaaatcac tgacgcgatg actgaaaaac ctgtcagtgt ggaggaagat 1338721 gcttcagtcg atgaggttct tcatttgatg gcatcgcatc agctcagaag gataccagtt 1338781 acaaaaaata aaaaactgac tggaattgtc acgcttggtg atctttcttt atctgagcaa 1338841 acgaatgaac gtgccggcag cgccttatcg gatatttccg aaggggataa tagagaagaa 1338901 ggcttttttc attaacacat aaatctttga catgttaaat aggctgtatt gtaatgggat 1338961 gtaaacaaga gattgtgaat cgccacgggg gtgatagatt gaaaaatata ttgagagcaa 1339021 tggttatcct tttgattatc tgcggaacct atgttctgtt tattcaatat ggatctgttc 1339081 ctgaaaagaa atcaaatgac agcgagcctc aggtgtcgaa tgaggaagcg caaagcggca 1339141 aacgaataca tatgccgact tcagggttat tgtccttcat gggcaagcac gccgatgaag 1339201 taacgaaaaa gcttggggaa cctgaacgta ttgacccttc ggcttatgat tacgattggt 1339261 gggtatacaa tcaaggtaag gatcaatata tccaaatcgg ggtattaaac aataaagtgg 1339321 tcacattatt cgcgtcgggt aatgatatta acgccaagcc tttcaaaatt ggagaatcaa 1339381 ctggcgaagt attcaagacc acccaggtgg caccatttgt gaatgtagag tataaaggaa 1339441 attcctatcg gtttgaattt tctgaagaag atatcaatac aagaccgact gtaaaggtag 1339501 gaaagatgta tgtccagctg tatatggaca aatttgaggg gaagctatcc agcatcaggg 1339561 cgtttgatgc gcagaccttt gtaaagcaaa gaccttatga ggtagtgtac cgcggggaat 1339621 taattaaacc gaaagccgtt tcagatgaga aatggaaaaa gatccaaaca acgagcgaaa 1339681 agcaaatcct tgatttgacg aatgtcatac gcgttaaaca tggacttgcg aagcttgagt 1339741 gggatcagcc aacggcggaa gtggcatttg ggcatagtga ggatatgaag gaaaataatt 1339801 atttctccca tgtctctaaa aaatacggct cgctgaaaga ccgcttagaa gaagggcatg 1339861 ttgattttca gcaagcggga gaaaatatcg catacaatta tgtggacggt ccggctgctg 1339921 tagaaggctg gctgaatagc gaaggccatc gaaaagcgct tctgaattca gattatacgc 1339981 atcttggtgt cggagtagac cggaaatatt acacccaaaa ctttattaag cgatggtaat 1340041 gaaagccgcg gacgaatggt tcccggcttt ttctatttcc atacaagctg gtctgaatga 1340101 atgtgctgat agcttacaga taaggccgtt tcccatccct tcagtcaggc tttttcacca 1340161 gtgtataggg atatcgctaa aaattcattt gggaatgaat ataggcgaac acaatgcccg 1340221 acaaaacgat acattgtagt aggtaacgat tttcggaggg ggtgaggatt gtggcgaatc 1340281 aacatgccaa tcattcaatc aatgacttta aacaattcgt caaaaagcat cccaagctga 1340341 taaaagaagt gcgcaaagaa caaagaagct ggcaggacgt atatgaaaat tgggtcctct 1340401 tcggggagag cgacccgatt tgggatccat atcgggaacc ggaagaagct tctgaagctg 1340461 tgcctgaaac accgcaaaaa aatgattttg tctcgaaaat ggtgacagcg gtgaaaaaga 1340521 tggatgtcaa tcaaatgaac gaacaaatca ataaaatgag ccagtcgatc tcatcgttgc 1340581 aaagccttct taatacattt tccggaagcg gacagaagca ttctcagcca ggctctggac 1340641 agcatccttt ttcttttcga aaggattaaa aaaggggagc tcatatgcgc aaagaggttc 1340701 aggaatatat tttagcaaac gaagaacgga aacgattcat cagagaacag ccgatatggt 1340761 accgcaggct ttcaagaaaa ccggatgatc tgtcctcctt tcagcttgaa atgatgaatt 1340821 tttatgaaaa aaccattccg catcgggtga atcagtttac gaacgggatt caaatggcgc 1340881 aaatgatgat gcaaatgttt caagcgatgc ggacaaaaga ttaaaaggcc ccgaagaagg 1340941 gtcttttttc atgcggtcat aaggttttgt tggcggctgc ggttaagcat tttccaattg 1341001 gctggtttca tggtaaacta acaactggag gtgcatgtta tgtatgcgac gatggaatcc 1341061 gtgcggcttc aaagtgaagc tcagcagctt gccgagatga ttctgcagtc ggagacggct 1341121 gagaactacc gcaattgtta caagcgtctc caggaagatg aagaggcagg tcggattatt 1341181 cgttctttta tcaaaataaa agagcagtat gaggatgtac agcgttttgg caaatatcat 1341241 cctgactata gagaaatatc ccggaaaatg agggagatca aacgtgagct ggacctgaac 1341301 gataaggtgg ctgacttcaa gagagctgaa aatgagctcc agtccattct tgatgaggtc 1341361 agcgttgaga ttgggacagc tgtttcggag catgtgaaag ttccgactgg gaacccttat 1341421 tttgacggtt tgtcttcatg cggaggcggc tgcggttcag gcggaagctg cggatgtaaa 1341481 gtgtcctgac gagactggcc gtctcgtctt ttacatataa gagaaaacag gcaggtgatt 1341541 gtattggaga ataggcgcca gggcatggtt gtgtatctgc actccctaaa gcagagcaaa 1341601 atgctgagga agttcgggaa tgtgcactat gtatcaaaac gattaaaata tgtcgtactg 1341661 tactgtgata tggaccaaat tgaaaaaaca atggacaaga ttgcgtctta ctcatttgtg 1341721 aaaaaagtgg agccttctta taaaccgttt ttaaaattgg aattcgagtc aaagcttgat 1341781 aaggcaaaag aatacgatta taaaatcggc atatagctat aaaaaaatcc ccgcaggcat 1341841 ctgcggggtc cttctattcc ttaatatgtt aaggagaagg caaagggaga ggagaaaccg 1341901 gaggaagaac ttatggggaa acgtaagtct tctccgcggt tggcaacaac atcctctaga 1341961 tgctgttgct tatagtatgg acaaggatca tgctgcctat acacctgttt atcaagatta 1342021 gcgttcattg tttggaagaa tgctttatgt taagatagga ttgatttttt tctatgtaca 1342081 tagcggcgtc cggccgaata aagaaacaaa atagctttta gaaaaagtgg tgtggaacat 1342141 gagagtaatt tctggatcaa aaaaaggccg ttcactaaag gctgtagccg gaacatcaac 1342201 aagaccgaca accgacaaag tgaaggaatc cattttcaat atgatcggcc cttattttga 1342261 cgggggcagg ggacttgact tattcgcagg gagcggaggt cttggaatcg aagcgctttc 1342321 acgcgggttt gagcattgta tattcgttga ccgtgatttt aaagcgattc aaacggtaaa 1342381 atctaatttg aaaacgctgg agcttacaaa acatgcacag gtataccgca atgatgcgga 1342441 acgtgctttg cacgctgctg ctaaaagaga aaccggcttt cgcggaattt ttctcgatcc 1342501 gccgtataag gaacaaaagc tgaaagcact tttaactttg attgacgaat atcaaatgct 1342561 ggaagaagac ggctttatcg tcgctgagca tgacagagag gtcgagcttc ccgaaaccgt 1342621 aggagatctt gtgatgacaa gaaaagaaac ctatgggtta acaggtgtag cgatttataa 1342681 aaagaggggg tagtgaggtg gcgagtatag ctgtctgtcc cggcagtttt gatcctgtga 1342741 cctacgggca tctggacatc atcaaacgcg gggcgcatat ttttgaacaa gtgtatgtat 1342801 gtgtgctgaa taattcttca aaaaagcctt tgttcagtgt ggaagaacgg tgtgagcttc 1342861 tgagagaagt cacaaaagac attccgaaca taacagttga aacatcgcaa ggcctgttaa 1342921 ttgattatgc aaaaagaaaa aatgcgaaag cgattttaag aggcttgaga gctgtatctg 1342981 attttgaata cgagatgcag gggacatcag taaaccgggt gcttgatgaa tctattgaga 1343041 cgttttttat gatgacaaac aatcaatatt cgtttctaag ttcaagcatc gtaaaagaag 1343101 tggcaagata caacggctcg gtatcagagt ttgtaccgcc ggaagtagag ttggcgcttc 1343161 agcaaaaatt cagacaagga tgagggtttt gactcatcct ttttttgttc cgtttgtcag 1343221 tctgtaagaa aaaatgataa tgtacgtaaa cagcgcgcat agtgtgacag caggtccgat 1343281 ctgcacaagc agattccagc cgtttataaa ggcagttgac atgtcactgc tgttaagaga 1343341 tttaaataca tactgatacg gatcatgcca tgctgtgtaa agaggtttcc ataaaagcat 1343401 gacgaagaca gcggcataaa cgccctgcag caaacgtgcg ataaagaatg gtttaaatct 1343461 aatgtcggtt tccgataaaa tacctgccac ctgagcttgt acggaaaagc cgctaaaccc 1343521 aagaataaag ctgacgataa tggctttttg cagaagagaa acatctgtct cgctgacaag 1343581 cttgctgcct aatgtaattt caaacatccc tgataaaagc ggaatgtcca attgagtcgg 1343641 aagctgaaac aaagtcagtg ctccttttgt gaaaacagac aaaacatcag tcagctggac 1343701 cactgacaac agccgattga agacagaaaa taaaataata aagccgccta ccataagaag 1343761 cgtttgaaca gaagacgtca cggcgtcgcc taaaatttta cctaagggcc gtttttctgc 1343821 aagtctggcg gtatgaagag cgtgtaaagc atctttgact gaagggaaag gtatcgtttt 1343881 ctttcttctg agatgctgct cttccttgcg gccataggag cgcattgtta aaccgacggc 1343941 aagattcccc aaatagtgtg cagaagctaa taaaatgcct agtgatgcgt tttgaaagaa 1344001 accgacggca acagcgccga aaataaagag cgggtttgaa gaattggtaa acgacgcgag 1344061 ccgttctgcc tctactcttg aaatctgatt ttcctgccgc agacgggcag tgagttttgc 1344121 gcccgctggg tttcctgatg ccattcccat agcaagaacg aagccgccga cacccggcac 1344181 gcgaaagatc ggccgcataa aaggctcaag caaaacaccg acaaaccgca caatgccaaa 1344241 gccgattaag agttcggaca gaataaaaaa tggcagcaat gacggaaaca caacctccca 1344301 ccacatagac agcccggttt tagaggcttc gaatgaggcc tgtggatgtg agatgacagt 1344361 cgctgttaaa aaaagaaaaa acgaggcaat caaaagtgta ttaatcttcg acaagttcat 1344421 tcttacctcc ccgatgctaa aaatgcccaa tgacatgtat atcatgataa aataatgtat 1344481 gatgtaaaac ggccaagcag tacctgtcct cttgattctt tgtactaata tacgagcata 1344541 ggggttcagt ttagaccata gaattcggta tacagggaat tcaggcagga ggttaacgct 1344601 ttggccaaac ctaaaatcgg gttagcgtta ggatcgggag gggccagagg gcttgctcat 1344661 ctcggtgtgc tttccagttt acataagcac caaattgaag tggatatgat tgcaggaagc 1344721 agcatgggcg ctttggtggg cagtttttac gccgccggac atgacgtggc aacgatgaaa 1344781 aaagtagcca aagcctttaa acgaaggctt tatgctgatt atacggtgcc gaaactcggt 1344841 tttttaaaag gtgaccgcgt cagacagctt gtgcatgctt atacattcgg aaaaccgatt 1344901 gaagagctcc aaatcccgct gggcattgtt gcgtgtgatc tacagacggg agaaaagatt 1344961 gtgttccgaa aaggatcagt gtcagatgca gtgagggcca gcatcagcat cccgggtatc 1345021 tttattccgc agcggctgga cggacgcctt cttgtagacg gcgcggtcgt cgatcgaatt 1345081 ccggtttctg ttgtgaaaga catgggagct gatattatca tcgcttcgga tgtttccagg 1345141 gttcgaaaaa ctgaaacagc agtgcatatt tttgatgtga ttatgcaaag tatggatata 1345201 ctgcaaaatg aattagtgcg gcatcaaaca attgccgcag atatcatgat tcgcccttcc 1345261 cttgaaacat acagctcaag ctcgtttgcc aatattgaag aaatgatatc ggcaggcgaa 1345321 gaggcgacaa accgaatgat cagcaagata agaaaagaaa tagagaattg ggagggctca 1345381 taatttgcta cgtaaaaaac attttagctg gatgctcgtc atcctcatac tgatcgccgt 1345441 tttatcattt ataaaacttc catactatat tacaaaaccg ggagaagcga cagagcttgc 1345501 ttcattgata aaagtggagg gaggctaccc ggaaaaagga agtctgtcct taatgactgt 1345561 taaagtggga ccggctaatc catttacata tgtgtgggca aagatgcacc cttattatga 1345621 aattgttcct gatgagagca ttaaggagga aggcgaatca gataaggagt atatgaaaag 1345681 acagctccaa atgatgaaaa gctcgcaaga aaatgcggtt atagccgcct atcaaaaggc 1345741 aggaaaaaaa gtcagctatt cctttaacgg catatacgca agctcagttg tagaaaacat 1345801 gccggcaaaa gggaaaatag aagtcggtga taaaatcatc agcgcagacg gcaaaaacta 1345861 tcagtctgct gaaaagctga ttgattatat cagcagcaaa aaagcgggag ataaagtcac 1345921 gttaaagatc gaaagagaag aaaaagaaaa gcgtgtcacc cttacgttaa aacaatttcc 1345981 tgatgagccg gatcgggcag gaatcggagt ttcgctttat acagacagaa acgtgaaggt 1346041 agagcctgat attgattttg aaatcgaaaa tattggcggc ccgtcagcag ggttaatgat 1346101 gtcccttgaa atctataatc agctgacaaa accagacgaa acaaaaggct acgatattgc 1346161 gggaacaggt acgattgatg ttgacggaaa agtaggcccg atcggcggca ttgatcaaaa 1346221 agtcgtcgcc gcagacaaag ccggaaaaga cattttcttc gcgccaaatc aaaacggcgc 1346281 cagcaattcc gattataaga acgcagtaaa aacagcaaaa gatattgatt caaatatgaa 1346341 gattgtgcct gttgatacca tgcaggatgc gattgattat ttgaataagc tgaaagcgaa 1346401 aagcacctga ttctcaggtg ctttttctat acatttaaaa agtgttgttc atcttcgtca 1346461 tatcgaatcg gtgcatgtcc gtattcctgt aggtcaaact cagttctcag cggctcttct 1346521 atcggcaggc tgtaaatcct gcttgctttt acgtccagat cgagagctgg atgggagaaa 1346581 gaggacagtt tgctgacaag cggaacagac agtgcttttt tcttttcgga taaataagcc 1346641 tgtccttttt tcgtcatgcc gagaagcctg atatacggcg ccttatcgtt gtcaagcagc 1346701 ttttgcatat cctgtttttt tgttctggtt aaaatgtgtg tattcatccg ctggagcctt 1346761 gtccacgtat agcgttttgt tttcagcagt tccataaatt cctgatagga gctggatttt 1346821 ctgatcgaac gaataattct gtgctctaaa ccttcctcca cctcgtatac ttgctgtaat 1346881 tcccgtgccg ttacagttga aaggctgtat tttaagtaag aaaagtagct ttcaggtgta 1346941 tgccacaatc cgaaagattt gcggtaagct gctaattcac gtgcagatgc agcagggaga 1347001 aaacgaaggc aggcttcgag attctggcca atcatcgctt ttctaatgct tgtggcactt 1347061 gctatatggt tttcgccttc agggagatcg gcatcatgat agtccgaaga gattcgtgcc 1347121 gtagtataag gtttcatagg atatcccccg gttagaatcg aggtcacata ctggtatccc 1347181 aaaatgttat ttggttttga caagtcaagt gcactttcag tatgcaaaat ggagctgaag 1347241 gcgatagccg ccgctgctgg gtaactggcc ccctttttaa gttcttcttt aattcggtca 1347301 ttcaatatat gtttatgctc atcaataagc tgtgctgttt ctaaaaaagg cttgatatcc 1347361 ccattttcac tcccgaaaaa cagcgcctca cattcaagtt cgttcaggat ggaaacactg 1347421 ccgcgtgcaa aaatgtctgc tttttgcacg gcataaagat aaggcagctc aatgacaaga 1347481 tcaactccgc tttgcagcgc catttttgtt cgggcccatt ttgatacaac agcgggttcc 1347541 ccgcgctgta aaaaatgtcc gctcatgacc gcgacagccg tgtcacatcc ggtttgcagc 1347601 tttgctgttt gggcatgata aaggtgaccg ttatgaaagg gattatattc aaccaccaat 1347661 ccgacagctt tcatattttt tccgcctttc ttgctatgtt taaaaacgta tggtacattt 1347721 gcaaatgaaa actcttacgc cttatttttg ttttaagtgt atgcatagca tattccgctg 1347781 tcaacgatac ttcaatggca gcattatgct gtaaagaaaa aatattgaca aaaacaatct 1347841 taaaagctat aatcatgttt gttgctttcc tgaggtgata caaatgaaat ggacgattta 1347901 tcagctgcat caaatgccaa aacaaagttt tgagtttgat gaaacagttg agttaaatga 1347961 gctgacaaag ctgaattctg acattcgccg catttctccc gttcgggtga agggcagagc 1348021 ggatatcaaa tccaaacagg tttcgtttga ttttacaatt tcaggcgaaa tgcttttgcc 1348081 atgctcaaga acactcgttg atgttccgta tccatttgaa atttcaacaa aagaactgtt 1348141 tatatttcat cacacggatg atatagaaga tgatgacgtt cacattgttg aggacgatac 1348201 tatcgacata actccgatcg tgaaagaaga aattctttta gaaatcccta tgcaaatctt 1348261 ttgtgaatct gaacaagaaa aaggagctgc tcctcaagaa ggaaaggatt ggcaagtcat 1348321 ttcggaagaa gacaagaaga atcaagttga tccgagactt gcagcccttg aaaagctctt 1348381 aaaacaagat gatgaatctt aactctttaa ggaggtggga ataatggctg taccttttag 1348441 aagaacttct aaaatgaaga aaagattgcg ccgtacacat ttcaaactta atgtacctgg 1348501 tatgacagaa tgtccgtcat gcggagagat gaagttgtct caccgtgtat gcaaagcatg 1348561 cggatcatac aacggcaaag acataaatgt aaaaagtaac taatgagaaa agcgcagggt 1348621 gaaagccctg cgctttttct ttttctcttc ctgtcagctt gcggaaaatt tgtgagtgca 1348681 aatagtctat ctaatctatt accggcatat gtatgagata aataagctga catggaggga 1348741 gattgaattt gaccattaca agacaagatg cttggactca ggatgaggat ttgctgctgg 1348801 cagaagtggt gcttcgtcat attcgagagg gaggaacaca gctttcagcc tttgaggagg 1348861 ttggaagggc gctgaccaga accgcggcag cctgtggttt caggtggaac tcgtatgtga 1348921 gaaaacaata ccagtcaggt atagagcttg caaaaaagca aaggaaagaa ctgagaaagc 1348981 aaatcggcgt tcattcggtc aatatgccga attccatgaa gcagactgcc tcggcatcgt 1349041 cagaaggaaa acgagatttg tccattcagg atgtcattca atttctcgaa caattcaaag 1349101 aaacaccgtc tgcacaagaa tttcagcttg aaagggaaaa attgaaggag caaatccaat 1349161 cgctgcaaaa agagcttgag gatttgcgga gtgaaaatca gacattgcgg aatcagctag 1349221 agatgacaga agaggattac aaggcactga tcgatatcat ggatcgggcc agaaaaatgg 1349281 ttgtttcgaa ggaagacgga agaatgaaaa aagcggctca agaaacgtaa agaaacgcct 1349341 gaaatgaacc ggccctatag taagaatagg ccggttgttt tgatttctat gcagactctc 1349401 ccggtgtcat ttcgcgatcc atatcaggat gccagatgag cgggttttcc cctttgtccc 1349461 gcgccatatc atacttaaca gttttaaagt tcattttgtt ccaaaattcc gctgatttca 1349521 ttctcggatt tgtccggatc ggcattttga atgattttgc aaattcaacc aaggctctcc 1349581 cgtatcccct gttctggtag cccggaagaa cctcaagctt ccacagctcc aaataatcct 1349641 ggcggttgtc aaaataggga ttcgatttgc cgttaacttg atacagactc attcgtgcta 1349701 caagtttatc gccaaaataa atcccgtaaa aaggcgaggt gctgtcattt tcaataatat 1349761 tatcctgaag ttcttcaagc attgaaagct cctgaatgcc gtattctttg aatttcttga 1349821 attcttccag cgttttatag ttgataagca gacgttctac ctttgtcaaa caaatctccc 1349881 cctttgttgt ttctacatat attgtaaacg ctttatttaa aaaatccaaa tatttaaact 1349941 ttaattttaa gcacatggga tctttgagaa gtaatttctt cttacttctg ctatgataat 1350001 acgtaaatgc taaattgggt gtgacatcat gaaaattgga attatcggcg gaggctccgt 1350061 tggtctttta tgcgcctatt atttgtcact ttatcacgac gtgactgttg tgacgaggcg 1350121 gcaagaacag gctgcggcca ttcagtctga aggaatccgg ctttataaag gcggggagga 1350181 attcagggct gattgcagtg cggacacgag tatcaattcg gactttgacc tgcttgtcgt 1350241 gacagtgaag cagcatcagc ttcaatctgt tttttcgtcg cttgaacgaa tcgggaagac 1350301 gaatatatta tttttgcaaa acggcatggg gcatatccac gacctaaaag actggcacgt 1350361 tggccattcc atttatgttg gaatcgttga gcacggagct gtaagaaaat cggatacagc 1350421 tgttgatcat acaggcctag gtgcgataaa atggagcgcg ttcgacgatg ctgaaccaga 1350481 ccggctgaac atcttgtttc agcataacca ttcggatttt ccgatttatt atgagacgga 1350541 ttggtaccgt ctgctgacgg gcaagctgat tgtaaatgcg tgtattaatc ctttaactgc 1350601 gttattgcaa gtgaaaaatg gagaactgct gacaacgcca gcttatctgg cttttatgaa 1350661 gctggtattt caggaggcat gccgcatttt aaaacttgaa aatgaagaaa aggcttggga 1350721 gcgggttcag gccgtttgtg ggcaaacgaa agagaatcgt tcatcaatgc tggttgacgt 1350781 cattggaggc cggcagacgg aagctgacgc cattatcgga tacttattga aggaagcaag 1350841 tcttcaaggt cttgatgccg tccacctaga gtttttatat ggcagcatca aagcattgga 1350901 gcgaaataca aacaaagtct tttgagcttt ttcggtaaca tgctatactc atttcggatc 1350961 actaactatt tattggagaa aggaagttct agaagatgca gctaactgaa ctttccatca 1351021 aaaatcagaa tgtgtttgta cagcactata tagatggcaa agaagaaatg tcttcttttt 1351081 ttgattacag tattcatcat aaggacatgt ggcgcgaaag actggaagac ttatcttccc 1351141 ggtttttcgc aagagaggaa ttggcggcgt acttaacctc ttaccataat aaattcggtt 1351201 caagtgcgat gcagtctgct attgagaagc tgaaggaccc gtcaagtgcc gctgtagtcg 1351261 gcggacagca ggcaggactt ttaacaggac cgctttacac catacataaa atcatttcaa 1351321 tcattgtttt agcaaagcaa caagaaaagg aactgcaagt gcctgtcata ccaatcttct 1351381 gggtggctgg agaagaccac gatttggatg agattaattt tgttcacaca tctgaagaga 1351441 atgggcctgt gaaaaaaaag ctgcctcagt cttattggaa gaaatcatca gcagcgagta 1351501 catcgcttga tcaggaaaag tgtgccgcgt ggatagatga tgtttttgcc gcttttgaag 1351561 aaacagacca tacgaataca cttctcgaca atgtgaaacg atgtttaagg gaatctgtta 1351621 cgtttactga cttctttgaa ctgctgatcg cggatttgtt ccaagaagag ggcttagttt 1351681 tattaaattc tggggatccg gggattaaaa agctggaaac ggccatgttc caaaagattc 1351741 ttcgagaaaa tgatgaactc gcccgggctg tatcagatca gcaggccttc atgcgtcaag 1351801 caggctacaa accgattatc gagtccggaa aagagcaggc gaatctgttt tatgaatacg 1351861 aagatgagcg ttttttaatt gaaaaagata acggccgatt tgtcatcaaa gagcttgatc 1351921 taggatggac gagggatgaa cttcatacac atatggaaga acatccagag cgtttcagca 1351981 acaatgttgt aacgagaccg ttaatgcagg aatttctcat tccgacttta gcatttattg 1352041 cagggcctgg ggaaatcaat tattggggcg agctcaaaca ggcatttgcg gtgatgggct 1352101 tcaaaatgcc tcctgtcatg ccaaggctga acattacgat acttgagcgg catattgaga 1352161 aaaaactggc tgaacggaat atctcattac aagacgcgat tgagcgcgga acggagaatc 1352221 aaagagagac atacttcgag cgccagattc cggaagagtt tacggcggtg atggatcagg 1352281 cgaaaagcca aattgaagcg attcacaaaa cggtccggca ggaggcgtta aaggttgatc 1352341 aaagcttgga acctttactt ctgaaaaatg ccgcttttat tcaggatcag cttcaattct 1352401 tagagcgcac ggtgatgaag cgaattgaag aaaaagaagg ctacgtcttg aaggattatg 1352461 aaagaattca aaatagcatt aagccgcttc ttgcgccgca agaacggatt tggaatatca 1352521 tgtattattt gaacaggtac ggtccaaaat tcttcacgac attcaagaat ctgccatttt 1352581 cttttcaaaa tcaacatcaa gttgtcaaac tttgaaataa agttttaaag aaccctgact 1352641 agttcagggt ttttttttat gggtaaacag tgtaaaatga agttgtggag cgaagtggtg 1352701 aatagtggtg agttaaggag agaaagtggg gcaagagatc atgtttatgg gtgaatatca 1352761 gcataccatc gatgcgaaag gccgcatgat cgtacccgct aaattcagag aaggcctagg 1352821 tgagcaattt gtgctgacta gaggacttga ccaatgtctc ttcggctacc ctatgcacga 1352881 atggaaacaa attgaagaaa aactaaaagc tcttcctctc acaaagaaag atgcccgcgc 1352941 gtttacccgt ttcttctttt caggggcgac tgaatgcgaa ctggataagc aaggcagggt 1353001 aaatatcgca tcatctctat tgaattacgc caaactggaa aaagaatgtg ttgttatcgg 1353061 ggtttctaat cgaattgaat tgtggagtaa agtaatttgg gaacaataca cagaagagca 1353121 agaagattca tttgctgaaa ttgctgaaaa catgattggg tttgatatat aatgattctt 1353181 cgtgtataac actctaaaaa caatttcaat tcatcctgat aaaaggtggg accaacacaa 1353241 tatgtttcaa cacaagacag tacttcttcg tgaaaccgta gacggactta atattaaacc 1353301 agacggtaca tatgtagact gcacactcgg cggagctggg catagtacat acttattgca 1353361 gcagttatcc gagaaggggc gtttaatcgc ttttgaccaa gatgatacgg cattacagca 1353421 tgctaaagaa gtgttgtccg attataaagg acagctcatt ctgattaaaa gcaatttcag 1353481 gtatttaaaa gaatatttga atgaacaagg cgttacagaa gtagacggca ttttatttga 1353541 tttaggggtg tcctctccgc agctggatac accggagcgc ggattcagtt accatcatga 1353601 cgcaccgttg gacatgagga tggaccagtc ggctacgctt tcggcgaaag aagtcgttaa 1353661 tgagtggcgc tatgaggatc tcgtccgtat tttctttaaa tacggagaag agaagttcag 1353721 taaacagatc gccagaaaaa ttgaggaggc aagaatgaag tctcctattc aaactacggg 1353781 ccaactggtc gatctaataa aagacgcgat tcccgctcca gcgagaagga gcgggggaca 1353841 tcccgctaaa cgcgtgtttc aggcaatcag aattgccgta aacgatgaac ttagggtgtt 1353901 tgaagaagct ttggagcagg caattgaggt tctgaagcca gggggcaggg tatcggtcat 1353961 taccttccac tcgctagaag acagaatttg caaaaccact tttaaagaaa agtcgtcgct 1354021 tccggaactt cctccgggac ttcctgttat accggaagag tttgaaccgg agctgaagct 1354081 catcacacga aaaccgatta cggcatctca agaagagctt gaagagaaca accgggctcg 1354141 ttctgccaag cttcggattg ctgaaaaaag aaaataacga aacgcgaacg caaaattaaa 1354201 aggaggtcat cagcctatga gcaatttagc ttaccaacca gagaaacagc agcggcatgc 1354261 gatcagtcct gagaaaaaag tgattgtcaa gaaaagggct tccattactc tcggagaaaa 1354321 agtgcttctt gtcctctttg ctgcggcggt gctcagcgta tcgcttttga tcgtatcgaa 1354381 ggcgtatgcg gcatatcaaa ccaatattga ggtgcaaaag cttgaggagc aaatttcatc 1354441 cgaaaataag caaattggtg acctcgaaaa aagcgttgct gatttaagca aaccgcagcg 1354501 cattatggac attgcgaaaa agaacggctt gaatttaaaa gataaaaaag tgaaaaacat 1354561 acaggaatga ttcaaatgcc aaaaaagaat aaatttatga atagaggagc agcgattcta 1354621 agtatttgtt tcgctctctt tttctttgtc atcctgggga gaatggcata tattcaaata 1354681 accggaaaag cgaacggcga agtgcttgcg acaaaagcga cagagcagca tgaaaagaaa 1354741 cggaccatcg aagcgagccg cggctcgatt ttagaccgaa aaggaaaagt cattgcagag 1354801 gacacagcga cgtataaact gattgcgatt ctcgataaaa aaatgaccac tgatgtcaag 1354861 catcctcagc atgttgtaaa caaagaaaaa acggcggaag cattgtctaa agtgataaac 1354921 ttggacaagg ccgacatcct tgatatctta aataaagatg caaaacaagt cgagtttggc 1354981 tcagctggcc gggatattac gtattcacaa aagcaaaaaa tcgaaaaaat gaaactcccg 1355041 ggcatttcat ttttacggga tacaaaacgc tactatccaa acggagtatt tgcatctaat 1355101 ctaatcggct atgccgaggt tgatgaagaa acaaatgaaa tttccggcgc gatgggatta 1355161 gaaaaagtgc tggataagta tttgaaggag cgggacggat atgtgacata tgaaagcgac 1355221 aaatccggct gggagctccc gaacagcaaa aataaaatta cagcgccaaa aaatggtgac 1355281 aatgtatatt taaccattga ccagaaaatt caaacctttt tggaagacag catgacaaaa 1355341 gtggcgcaaa agtataatcc gaaaaaaatc atggccgcag tcgttgatcc gaaaacgggc 1355401 aaagtccttg ccatgggaca gcgcccaagc tttgatccga acaagcgcga tgtgacaaac 1355461 tactataatg atttgatttc atatgcgtat gaacccgggt ccacgatgaa gatctttaca 1355521 ctcgctgctg cgatgcagga aaacgtgttt aatgcgaacg aaaaatataa atcagggaca 1355581 tttgaagttg gcggagcacc tgttaaggat cacaataacg gtgtaggctg gggtccgaca 1355641 acatatcatg acggcgtcct aaggtcgtcg aatgtcgctt ttgcgaaact ggcgaaagaa 1355701 aagctgggat atgaccgcct caatcaatat ttgcacaaat tcaattttta ccagaaaaca 1355761 ggtattgatt tgccaggaga agtctccagc aaaatcaact ttaaatatga atttgataag 1355821 gcgtcaactg catatggcca agcgtctgcg gtcacaccaa ttcagcagat tcaggccgca 1355881 acggcaattg caaatgacgg taaaatgatg aaaccttatg tcattgacca tatcgttgac 1355941 cctgataaag ataaaactat ttatcaaaat aagccggaat cagccggaac tccaatttct 1356001 gcaagtactg cgaaaaaggt gcgggatata ttaggagaag tcgttacatc gaagatcgga 1356061 acagggcaag cttataaaat cgaaggtttt gatgttgccg ggaaaacagg tactgcgcaa 1356121 atagccggta aaggcggata tttagacggc acagataact atatcttttc gtttatgggt 1356181 atggcgccaa aagatgatcc tgagctttta atttatgttg ctgtacagca gccgcaacta 1356241 aaagcaggac aaagcagttc agatccagta tcagaaatct tcaatccaac aatgaaaaat 1356301 agcctgcact acctaaacat cgaaccaact gaaaaatctg actcagataa ggaagaaaca 1356361 aaagcgcaga caatgcctga tttaacagat caaacggtag ctgctgctca aaagaaagca 1356421 aaagaggaga atctcacacc aattgtcatc ggcagtgatg tcgctgtaaa agaacagtat 1356481 ccgaaagcgg atgaggaagt tctcaccaat caaaaggtct tcctgaaaac gggcggcaaa 1356541 atcaaaatgc ctgatatgac aggctggtcg agaagagagg ttctgcagta cggcgagctc 1356601 gcgggaattc atattgaagt aagcggacaa ggctacgctg tcagccaaag tgttaagaaa 1356661 gacaaagaaa tcaaagacaa aaccgtaatc aaggttaagt ttaaaaatcc tgattaaaaa 1356721 gaaagccgtc gttatgcagg ctttcttttt ttatgccttc agaggagcat cgttctacct 1356781 gtccaaattc aggcataaaa tgaaacaagc ctaaataagg agtgaacggt ctcttgcgcg 1356841 tctcgaatgt aacggttaga aaacgtttat tatttgtttt gctttttggc gtgatcgtgt 1356901 ttctgatcat tgatacaagg ctggggtatg ttcagtttgt gatgggcgaa aaactgactt 1356961 cgctagcgaa agattcctgg agccggaact tgccgtttga gccggagaga ggcgagattc 1357021 tggatcggaa tggtgtgaag ctcgcaacaa ataaaagtgc gccgaccgta ttcgtcgtgc 1357081 cgcgccaagt tcagaatccg atgaaaacga gcaagcagct tgcggcggtg ctcaatatgt 1357141 cagaagaaaa agtatataaa catgtgacaa aaaaagcgtc aatcgaaaag atcactcctg 1357201 aagggagaaa aatttcaaat gagaaggcga aagaaatcaa agcgcttgat ttaaaaggtg 1357261 tgtatgttgc ggaggacagt atccgtcatt acccgttcgg cagcttttta tctcatgtgc 1357321 ttggatttgc aggaattgac aaccaagggc tccttggact tgaagcctat tacgacgatg 1357381 atttaaaagg ggaaaaaggt tctgttaagt tttatacaga tgccaagggg aagaagatgc 1357441 ctgatgaagc ggatgactat acgccgccta aggatgggct tgatatgaag ctgacagttg 1357501 attcaaaggt tcagacgata atggaaagag agcttgataa cgctgaggcc aaatatcatc 1357561 cggacggcat gattgccgta gccatgaatc cgaaaaacgg agaaattttg gggatgtcta 1357621 gcaggcctga cttcgaccct gctgattacc aatctgttga tccgtccgtc tacaatcgaa 1357681 atctgccagt atggagcacg tatgaaccgg gatctacctt taaaattatt acacttgcag 1357741 cagcccttga agagcaaaaa gtaaatttga aacgggatca attttatgat aaagggcatg 1357801 ctgaagtgga cggagcgaga ctgcggtgct ggaaaagagg cgggcacggg ctgcagacgt 1357861 atctggaagt tgtgcagaac tcctgcaacc cggggtttgt tgaattaggc gagcgcttag 1357921 gaaaggaaaa gcttttcaaa tatatcaaag actttggttt tggacaaaaa acggggattg 1357981 atctccaagg cgagggaaca ggcatcttat tcccgcttga gagagtgggc ccggtggagc 1358041 aagcaactac ggctttcgga cagggagtat ccgtcacgcc gattcagcag gttgcagcag 1358101 tatccgccgc tgtaaacgga ggaacgctct atacacctta tattgcaaag gaatggatcg 1358161 atcctgttac gaagaaaacg gtcaaaaaac aatcaccaat cgcaaagaaa caagtcattt 1358221 ctgaggaaac atccaaacaa atccgctatg ctctagaaag cgtcgtcgca gaaggaaccg 1358281 gccgcaatgc atttgtagaa ggatatcgtg tcggaggaaa aacgggaact gcacaaaagg 1358341 ttaaagatgg aaaatatctt gaaaacaacc atattgtatc atttatcggt ttcgcgccag 1358401 cagatgatcc gagtctagtc gtctacgttg cggtggataa cccgaaaggc acgattcagt 1358461 ttggcggaac ggtggcagcg cctattgtcg gaaatattat gagagacagt ctgccggaac 1358521 ttggtgtgaa gccccggaaa aatcaaatcg agaaaaaata ccaatggaac gacacaaaaa 1358581 caatagaagt tccgaatgtt gtagggatgt ctgtctcaga tcttgagtca ctattggtga 1358641 atctcaatgt ggatgcttcc gggaaaggga gcaaaatcgt taaacaatcg ccagctgccg 1358701 gaacgaaagt aaaagaaggc tcaaagatac gcgtgtattt gactgaagaa gatgaaaagg 1358761 aggcagccga ttgattcggg ctgcctattc ttttattgca gaaaaaatgc tgatatcttt 1358821 caagattagc tggatgtatc cttttattta cgctaaaata tgaactgtat gcttaaaatc 1358881 attaccacat catttgatgt gacttcaatg ataaaaagaa cgaattagaa tgttgagagg 1358941 tttgatacga tgaaacttac aaagctgctt acatacttaa caaccgaacc ttctgtaaac 1359001 gactcacaag accctgaaat aacttcaatt gagatggact ccagggaagt aaagaaaggg 1359061 agtctttttg tatgtgtaaa agggtatacg gtggatggcc acgattttgc gcaaaaagca 1359121 gtagaaaacg gtgcagcggc tattgtggca gaaagagagg tcgatgtgaa tgttcctgtt 1359181 attattgtcc ggcagtcact tcgcgcgctc agcgttttgt ctgatgcgtt ttacggacag 1359241 ccgacgaaga agcttcagct gattgggata acagggacaa acggcaaaac atcaacgacc 1359301 cacatggtcg atgagattct gaaaaaagcg ggaaaacgca caggcttgat cggtacaatg 1359361 tacatgaaaa tcggagacga aacacttcct gttaaaaaca cgactccgga aagcgtcacg 1359421 ctgcagaaaa cgtttaagaa aatgaatgac aagcacgttg acactgcaat catggaggtt 1359481 tcttcccacg ctttgtcttt aggacgcgtc catggctgtg attatgatat tgccgtgttt 1359541 acgaatttaa cacaggacca tctggactat cataaaacga tggatgagta ccggcatgca 1359601 aaaagcttgc tcttttccca acttggcggg gctttcaacc atgaacatcc aaagcgtgcc 1359661 gtcctgaatg ctgacgatga ggcgagcgct tattttgaaa aggtaacagc tgcgcatatc 1359721 tctacatacg gaattaaaaa cgatgctgat gtgatggcga agaacatcag tatcactgca 1359781 cagggcacaa gctttgatct cgtgacaaac aaaggcacga agcacatcac gatgtctctc 1359841 gtcggacaat ttaatgtgta taacgtgctg gccgctgttg cgacatgtat tgcagcaggc 1359901 ataccgtttg aaatcatcac tgaggctgtt gaagaattgc atggtgtaag aggccgtttt 1359961 gaattggtca atcagcagca ggagtttcct gtcattgtag actacgcgca cacaccggac 1360021 agccttgaaa atgtgctgga gacatgcaga gacatgacgg aaggaaagct atttgtcgtt 1360081 gtcggctgcg gaggagacag agataagacg aagcgcccga aaatggctaa aattgctgtg 1360141 gagctggctg acgagccgat tttcacgtca gataacccga gaagcgaaga tcctcgcgcg 1360201 attttaagag atatggaagc cggagtagag aacgcatact atcacagtat tgcaaaccgc 1360261 gagcaggcga tctttttcgc aattgccaat gccaaaaaag gcgacgttgt cctcattgcc 1360321 ggaaaaggac atgaaaccta tcagcagatc ggaaatgaaa ctttcgattt tgatgatgct 1360381 gaagtagcgg cgagagccat tgttgaactc aataagaata agacgaattc ataggaaaga 1360441 gatgttactg aataatggag cttgaaaaga tttttcatat ggaaaaaaat catgaatatg 1360501 ataactacgt atgtcgtttg aaagaaacag gaggagaaaa ggacaatgct tgagcaagtc 1360561 attctgttta caattttaat ggggttttta attagtgttc tgctctctcc gattcttatt 1360621 ccgtttttaa gaagattaaa attcggccag agtattagag aagaaggacc gaaatcacat 1360681 cagaaaaaat cagggacacc gacaatgggc ggggtcatga tcatactttc tatcatagtg 1360741 acaacaattg ttatgacaca gaagttttca gaaataagcc ccgaaatggt gctgcttctg 1360801 tttgttacgc taggctacgg tttgcttggc tttttagatg attacatcaa ggttgtcatg 1360861 aagcgcaatc ttggattgac atcaaagcaa aagctgatcg gacaaattat tattgcggtt 1360921 gtattttacg ccgtgtatca ttactacaat tttgcgacgg atattcgcat tcctggaact 1360981 gacttatcat ttgatcttgg ctgggcttac tttatccttg tgctctttat gctagtcggc 1361041 ggatcaaacg cagttaacct gactgacggc cttgacgggt tattatccgg tactgcggcg 1361101 attgcctttg gcgcctttgc cattctggca tggaatcagt ctcaatatga cgtagcgatt 1361161 ttctcagttg ccgttgtcgg tgcagttctg ggcttccttg tatttaatgc tcatccggcc 1361221 aaagttttta tgggagatac gggatcgctt gcattgggag gagccatcgt taccattgcc 1361281 attttaacga aattagagat cctgctggtt atcatcggcg gtgtattcgt tatcgagaca 1361341 ttatccgtta ttttgcaggt catcagcttt aaaacgacag gtaaacgaat ctttaaaatg 1361401 agtccgcttc atcaccatta tgagcttgtc ggctggtctg aatggagagt agtcgtgacg 1361461 ttttgggctg cgggactttt gcttgccgtt ttaggaattt acatcgaggt gtggttataa 1361521 gtggaaaatg atcaattttt acagaaacag cattttttaa tccttgggct tgcgaaaagc 1361581 ggatatgcgg cggcctccat tcttcatgaa aaaggcattt atgttgcagt caatgatcaa 1361641 aagccttttg aagaaaatga accggcacaa aagctttctg aaaaaggaat cgaagttgtt 1361701 tgcggagagc atccagtttc tctgttcgat cagcatcaaa tcacgattct gatcaaaaac 1361761 ccgggaattc cttatgaaaa tatcatggtt caggaagcag agaaacgagg tattccggtt 1361821 tggacggaaa ttgagctcgc ttactacctg accagcgcca agtttatcgg gattaccgga 1361881 tcgaacggta aaacgaccac gacaacgcta atttacgaaa tgctcaaggc tgactcgcaa 1361941 aaagcactga ttgccggaaa catcggcaca gtcgcaagtg aggttgccta tcatgctgat 1362001 ggagatgaat ggatcgttac cgaactgtct tcgtttcagc tgatgggaac acacgctttc 1362061 agaccggaaa tcagcctgat tttaaatgta tttgacgccc atctggatta tcaccatacg 1362121 cgcgaaaact atgaaaaagc gaaacagaaa gtgtaccttc atcagactgc ttcagataaa 1362181 gctattgtca accaggatga tgaaaccgtc gtgcgtcttg ctgaagccgg aaaagccgaa 1362241 atcgtcccat tttcagtcag caaaacgctt gaacagggcg catatgtaaa agacagtatg 1362301 attatgttta acggcgaagc cattcttcct ctggaagagg ttgtactgcc cggtgctcat 1362361 aacctggaga acattttagc agctattgca gttgtgaaaa cggcaggagc atccaatgag 1362421 gcggttaaaa aggtgctgac aagctttact ggtgtgaagc accgcctcca atatgtcaca 1362481 actgtgaatg gccgcaaatt ttataacgac agtaaagcaa caaacattct ggcgacaagc 1362541 aaggcgcttt cagcttttga taagccggtc attctgcttg cgggcggact ggatcgcgga 1362601 aatggttttg atgacttgaa accttatatg aagcatgtca aagcagtgct tacatttggc 1362661 cagacggcgc caaaactcga gaaactcggc aatgaactgg gaatacaaca tgtcaaacgt 1362721 gtcgataatg ttgaacaagc agtatctgcg gcgtttgcgc tctcaaatga aggagatgtc 1362781 atcctgctgt cacccgcgtg tgcgagctgg gatcaattca aaacatttga agaacgcggt 1362841 gacatgttta tagatgccgt gcatatgctt aagtaagggc ttgtcttgaa gtaaatcggc 1362901 agccctaatg actttaagct tggggtgtcg attgctttga ctactaaaaa aacatcgcct 1362961 gatttgttat tggtcatcat tacgttatta ttattaacaa tcggattaat tatggtgtac 1363021 agtgcgagtg cggtatgggc ggattataaa tttgacgact cattcttttt cgcgaaacgg 1363081 cagcttttgt ttgcgggaat cggcgtcatt gctatgtttt ttatcatgaa tgttgattat 1363141 tggacttgga ggacatggtc caaattgctg atggttatct gctttttcct tctggtgctt 1363201 gttttgatac cgggcgtcgg aatggtgcgg aacggttcaa gaagctggat cggagtcgga 1363261 gcattcagca tacagccttc agagtttatg aagcttgcga tgattgcatt ccttgctaaa 1363321 tttctctctg aaaaacaaaa aaacatcaca tcgttcagac gggggttcgt ccctgcactt 1363381 ggcatcgtgt tttcagcatt tttgattatc atgtgccagc ctgacctcgg aacggggaca 1363441 gttatggtcg gaacttgtat tgtcatgatt tttgtagccg gcgcacggat cgcccatttc 1363501 gtctttctcg ggctgatcgg cctcagcgga tttgtcgggc tcgtactatc ggctccatat 1363561 cggataaagc ggattacctc atacttaaat ccatgggaag acccgctcgg aagcggattt 1363621 cagatcattc aatcgcttta tgcagtgggg cccggcgggt tgttcggaat ggggctcgga 1363681 caaagcagac agaagttctt ttatctgcct gagccgcaaa cagactttat tttcgccatc 1363741 ttgtcagagg agctgggctt tatcggggga acacttattt tgctcctctt cagcgtcctg 1363801 ctgtggagag gaatcagaat tgcgcttggt gcgcctgatc tgtacggaag ctttgtcgca 1363861 gtcggcatta tttcaatgat tgccattcaa gtcatgataa atatcggcgt agtcacgggc 1363921 ctgattcctg taacaggcat cacgctcccg tttctgagct acggaggctc ttcattgact 1363981 ctaatgctga tggcagttgg tgtgctgctg aatgtaagcc gctactcgag gtattaacga 1364041 atgtatttcc aagcctcctg tctaacatga agcttggaaa caattgatgc gataaccctg 1364101 tccaacaaaa cagggttatc gttatgttat agagaaactt agactggggg aaaaaagaaa 1364161 tgcgaattgc aataagcgga ggcggtacag ggggacatat ttatcctgct cttgctttta 1364221 ttaaagaagt gcaaagacgt catcctaatg tggaattttt atatatcgga acagaaaacg 1364281 ggctggagaa aaaaattgtt gagcgggaga atataccgtt tcgttcaatt gaaattacag 1364341 gatttaaaag aaaattgtca tttgaaaatg tcaagactgt gatgcgtttt ctgaagggcg 1364401 tcaaaaagag taaatcgtat ttagcggaat ttaagcccga tgccgtaatt ggaacgggcg 1364461 gttatgtatg tgggccggtt gtctatgccg ctgcgaaaat gggaattccg actattgtcc 1364521 acgaacaaaa cagcctgccg ggcatcacga ataagtttct ttcaaaatat gttaataaag 1364581 tagcgatttg ttttgaagaa gcgaaatcac attttcctag cgagaaagtt gtatttacgg 1364641 gaaacccgag agcctctgaa gtcgtctcaa taaagacggg acgatcattg gctgaatttg 1364701 ggctttctga agacaaaaaa acggtcttaa ttttcggcgg aagccgaggc gctgcaccga 1364761 ttaaccgcgc tgtcattgac atgcaggatg tgctgaaaac aagagactat caagtgctgt 1364821 atatcaccgg tgaagttcac tatgaaaaag taatgaatga gctgaaaagc aagggtgccg 1364881 ctgataatat ggtcacaaag ccgtttcttc atcaaatgcc tgagtattta aaggccattg 1364941 atgtcattgt ggccagagcc ggtgcgacaa cgattgccga aattactgct ctcggaatcc 1365001 caagtgttct gatcccaagt ccatatgtga cagcgaatca ccaggaggtc aatgcgaggt 1365061 ctcttggcca gcatgatgcg gcgattgtac tgaaagaaac agagctcagc ggggagaagc 1365121 tgattgaagc gctagaccgg attgtactga atgagcaaac gttaaaggaa atgagcgaac 1365181 gaacaaagtc actcggtgtt cctgacgcgg ctgcccgttt atacagcgta ctcgaggaat 1365241 taaaaaaata gtagaaaagc aaatggaatg cggaggttta cgatggagaa agtgatacag 1365301 gaattaaaag aacgagaagt cggcaaggtt cttgcaaatg aaccgctcgc gaatcataca 1365361 acgatgaaaa tcggcggacc tgcggatgta ttggtcattc caagcagtgt ggatgctgtt 1365421 aaagacatca tggacgtgat taaaaaatat gatgtgaagt ggacagtcat cggccgcgga 1365481 tcaaatcttc ttgttttaga tgaaggaatt agaggcgtag tgatcaagct gggggcgggt 1365541 cttgaccatt tggagcttga aggggaacaa gtaacagtcg gaggcggtta ttcggtggtc 1365601 cgccttgcta catcattgag caaaaaaggc ctgtccggtt tggaatttgc tgccggcatt 1365661 ccaggatcag tcggcggagc ggtttatatg aatgccggcg ctcacggttc tgatatgagc 1365721 gagatcctcg tcaaagcgca tattttattt gaagacggaa cgattgagtg gctgacaaat 1365781 gagcagatgg atttcagcta caggacatct gtactgcaaa agaaacgccc gggcgtttgc 1365841 cttgaagctg ttttgcagct tgagcagaag gataaggaat caatcgttca gcaaatgcaa 1365901 agcaataaag actatagaaa aaatacacag ccgtattcaa gcccttgtgc gggaagcata 1365961 ttcagaaatc cgcttccgaa tcatgccggg aaccttgtag aaaaagcagg cttgaaagga 1366021 tatcaaatcg gcggtgcaaa gatatcggag atgcacggaa acttcatcgt caatgcgggg 1366081 ggagcatcag caaaagatgt gcttgatctc attgaccatg tgaaaaagac aatccgtgaa 1366141 aaatacgaga ttgatatgca cacagaggtt gaaatcatcg gcggaaatcg ctgattcaag 1366201 ttctgactga agctgttcat atgatatact gtaagcaaac gacaaacggc atcatagtat 1366261 gccgtttgtt ttggaataga cagactttta acagctgttt catttgaatg aggtgaacag 1366321 gcaatgaacc cgggtcaaga ccgagaaaaa atcgttaaca ttgaagagcg gatccctaaa 1366381 attaaagagc agaggaaaca aaaggcaaac cgccgtctca tttcatttat tatgctcttt 1366441 tttattatgg tgctgatcat tgtgtacctg caaacaccaa tcagtaaagt atcaacaatc 1366501 tctgttacag ggaatgaaaa tgtatcaaaa aaggaaatta tcgacctttc cgatattaac 1366561 agcggagata ctgagttttg gagtttggac aagcaaaaaa cagaaaagaa gattcagcaa 1366621 aataaattag tgaaaaaagc ggagatcagc aaatcgcttc ctaataaaat caacattgca 1366681 atcgaagaat ataaagcgat tgcttattta gaaaaagacg atgtgtacta tgaagtgctt 1366741 gaaaacggct cagttctgcc aaacgaagta acgccggatg atgccggacc gattttagtg 1366801 aattggacaa acgcgaagaa gcggtctcaa atggccaagc agctcgatgc gttgtcaaat 1366861 tcgttaaaac agtcgatttc agaaatttat tatacgcctg taaaaatgga tgaaaaccgt 1366921 attaagttgt acatgaacga cggttatgtt gttacggcat ctattaaaac gtttgcagac 1366981 cgaatgaaga cgtatccttc tatcatctca cagctaagca gcaataaaaa aggaatcatt 1367041 catttagaag ttgccaccta ttttgaagag tttgggaaaa acgataaagc tgctaaaaag 1367101 gaagatgaaa attgaggggc aaatcagcag tccttctttc cttgattatg cttatcgcag 1367161 gttttttgat ttcattttct tttcaaatga caaaagaaaa caacaaaagc gcggctgaga 1367221 cggaagagtg gaaaaaagaa tatgcgctga gagatgaact gctgaaacaa gagaaagaaa 1367281 ataagaagtt tgaaaaagaa ttatatcaaa agcaaaacaa agtccgccag gcggaaaata 1367341 agctgaagaa agagaagtcg gaatactata atgtcctcga agatacagaa aaatacagga 1367401 tgtatattgg ggaagtcggt gtgcagggag aaggcgttga ggtgacattg gaagatgcgt 1367461 catacatacc ggaaggggag aatgtgaata gttacatcgt tcacgaaagc catatcttcc 1367521 aagtagtaaa cgaactgtat atctcaggag cggcagctgt cgccgttaat ggacagcgtt 1367581 tgacgcatga ttcgtatatc aaatgcaatg gtcctgtggt aacggtagac ggggtgcagc 1367641 atcccgctcc gtttacggta tccgctattg gagatccaga tgtcctgctg ccctcgttaa 1367701 atatcgctgg aggcctaatt gatcagctgt caatggatca tatttctgtg tcggcagaaa 1367761 aagagaaaaa cgtacaaatg aaaccgattc tgaaaacgaa ggaatgactg aaaaagcggg 1367821 tgaaatagat tgaaaataaa gcgttccttc ataagcatca gtgttcttat ggtcatcttc 1367881 ggcctgatga tatctgttca gtttaattcg ttaaagcacc ccaaagtccg ggatacaaga 1367941 gatatgtggg atattaggga agagctgaca tcagagcaga agaagcagga aaagctgctg 1368001 gctgaaataa acaaatatga caaattgctg aatagctatt cgcaaacgaa agaaatgaca 1368061 aaagaaaccg cgctaaataa taccttgcaa tccttaaaaa aaacagccgg catgaccgat 1368121 ataacaggta gcggaattgt cattacgatt tccccgcttt tttctgaaag cttaacagga 1368181 gagccgatcg aaaatccgcc tccggatttg ctgaaaaagc tgataaatga actcaactcc 1368241 tacggtgcag agcatatctc gattaatgag cgaagagttg tgaatcatac agtcatcaga 1368301 gatataaacg gcactacaaa aatagacgga tacgcccttg acgattatcc tttaacagta 1368361 aaagtgcttg ccaaagatcc ggacatgtta cacagcagag tgaaggggtc aggccttgag 1368421 gatctttttg catctgaaaa tttagcatta aaagccggta aatctgaaag caaactaaca 1368481 ttaaaagcat atgacagacc actggacgta caacagctga aactgcttaa agactgaaaa 1368541 ggaggagaat tgtcatgtgg ctgcccgtgt tgggactggt gctcggaata gcgattggac 1368601 taatgacaaa cttaacgata ccgagtgaat actcaaacta tttatcgctt gcggtgcttg 1368661 ccgcacttga tacattaatc ggcggaatca gggcgcattt acaaggtaca tatgatgaaa 1368721 tggtatttgt ttccggtttc ttttttaata ttatattggc aataagttta gcttttctgg 1368781 gagtccatct tggtgtagac ttgtatttag caggtatatt cgcatttgga gtcagattat 1368841 ttcagaatat agccgttatc agaagaaatc tactaacaaa gtggactctt tctaaaaaaa 1368901 ataaaaaaaa tgtgatataa aagaggatat acataggata taacgaatat tttcaataaa 1368961 cataaaatgt gaaaagcaca taaaaatatt ctgttgttat tttttgttac acacttgtaa 1369021 agccacattc attgtattgt tgttccgcaa ataatagaat agaaatgatc gaaatgtgag 1369081 gaggtgccat agaatgaaca acaatgaact ttacgtcagt cttgacatcg gtacgtccaa 1369141 tacaaaagtg atcgtcggag aaatgacaga tgattccctt aatattatcg gtgtgggaaa 1369201 tgtaccgtct gaagggttga aaaaaggctc aatcgttgat atagatgaga ccgttcattc 1369261 tataagaaaa gcgtttgacc aagctgaaag aatggtaggt tttccgctta gaaaagctat 1369321 tgtcggcgtt aatggaaatt atatcaatat tcaagataca aacggtgttg tagcagtttc 1369381 cagtgaaaat aaagaaattc aggttgaaga tgtacgccgt gtcatggagg cggcacaggt 1369441 tgtttccgta ccgcatgaac agctgattgt tgacgtcatt cctaaacagt ttatcgtaga 1369501 tggaagagat gaaatcaccg acccgaaaaa aatgctgggt gtgcgtttag aagtagaggg 1369561 caccttgatc accggttcaa aaacaatctt acataactta ctccgctgcg ttgaaagagc 1369621 tggtattgaa ataactgata tttgccttca gccgctggca gccggttctg ctgcattatc 1369681 aaaggacgag aaaaaccttg gtgtggctct cattgatata gggggagggt caacaaccat 1369741 tgccgtattc cagaacggac atctcacttc tacccgtgtc attcctctcg gaggcgaaaa 1369801 tatcaccaaa gatatctcca tcggattgag aacgtcaaca gaagaagcag aacgcgtgaa 1369861 aaagcaactt ggacatgcct actatgacga agcctcggaa gatgaaatat ttgaggtaac 1369921 cgttataggc accaatcaaa aacaaacatt tacacagcaa gaagcagcga atatcattga 1369981 agcgagagta gaggaaattc ttgaaattgt ttcagaagag cttcgcagta tgggaattac 1370041 cgatctgccg ggaggcttcg tgctgacagg aggacaagca gctatgccgg gtgtcatgtc 1370101 tttggcacag gatgtgctgc aaaacaatgt cagagtggca agcccgaatt atatcggtgt 1370161 aagagatcct caatatatga cgggagtggg cctgatccaa ttcgcctgcc ggaatgcaag 1370221 aatccaaggc agaaaaatag gctttaagat gcctgaagaa gcgatacagg aaatcgcagt 1370281 ctcatcatct gaggaacaag agcagcatca tcaccaaaat gaggtgcagc agcggccaaa 1370341 aggaaaacaa aaaacacaag ccgaacataa taaacagagc aaaatgaaaa aactattaag 1370401 catgttttgg gaatagatag atagtcattc ggcagattag gaggatttag catgttggag 1370461 ttcgaaacaa acatagacgg cttagcatca attaaagtaa tcggagtagg aggcggcggt 1370521 aacaacgccg ttaaccgaat gattgaaaat gaagtgcaag gagtagagta tatcgcggta 1370581 aacacggacg ctcaagctct taacctgtca aaagcagaag tgaaaatgca aatcggcgca 1370641 aagctgacta gaggattggg agcaggtgcg aatccggaag tcgggaaaaa agccgctgaa 1370701 gaaagcaaag agcagattga agaagcactt aaaggtgctg acatggtatt cgtgacagct 1370761 ggtatgggcg gcggaacagg aacaggtgcc gcaccggtta tcgcacaaat cgcgaaagac 1370821 ttaggcgcat taacagtcgg cgttgtgaca agaccgttta ccttcgaagg acgcaaaaga 1370881 cagcttcagg ctgcaggcgg aatctcggca atgaaagaag cggtggatac actgatcgtg 1370941 atcccgaacg accgtatcct tgaaattgtt gataaaaaca caccgatgct tgaagcattc 1371001 cgcgaagcgg ataacgtact tcgccaaggg gttcaaggta tttctgactt gattgctaca 1371061 cctggtctta tcaaccttga ctttgctgat gtgaaaacaa tcatgtcaaa caaaggatct 1371121 gctttgatgg gtatcggtat tgctactggg gaaaatcgcg cggcagaggc agcaaaaaaa 1371181 gcaatttcca gcccgcttct tgaagcggcc attgacggtg cgcaaggcgt cctcatgaac 1371241 atcactggag gaacaaacct cagcctatat gaggttcagg aagcagcaga cattgtcgct 1371301 tcggcgtctg atcaagacgt aaacatgatt ttcggttctg ttattaatga aaatctaaaa 1371361 gatgagattg tggtgacagt gattgcaacc ggctttatcg aacaagagaa ggacgtgacg 1371421 aagcctcagc gtccaagctt aaatcaaagc atcaaaacac acaatcaaag tgttccgaag 1371481 cgtgagccaa aacgtgagga acctcagcag cagaacacag taagccgtca tacttcacag 1371541 ccggctgatg atacgcttga catcccgaca ttcttaagaa accgtaataa acgcggctaa 1371601 tgtaaaggac aaaatcgttt tcgattttgt ccttttttgt ttttctcttc acactttcct 1371661 tcttataaag tctttttccc tattgcttcc ttcgcgagct cgattatgga tggtttacgt 1371721 tttggaaaaa gtaaggtatc ctagttcgta caaagtttta tgaaaattaa aacaattata 1371781 aaaggcaata aagaggagga ccacgatgat tttgcagctt gacaatgtct cactaaaacg 1371841 gaatgggaaa tggatactga aagatattca ttggaaggtg gaagaaaagg aaaattgggt 1371901 gctttacggc ctaaatggcg ccgggaagac agcgctgtta aatatgcttt gctcatatta 1371961 ttttccaaca tcaggcgaga tgcaggtgct cggccatgaa tttggcaaaa cagagcttgg 1372021 ggaaaagctc agacgtaaaa ttggcctcgt ctcagcagct cttcagcaaa aattgtatcc 1372081 ggcagattca gcttttgaaa ttgctttgag cggagcttac gcttcgattg ggttatatga 1372141 aacgccaagt aaggaaacca gggaaaaagc gataggtttg ttagaggact tgggagcaat 1372201 tgaatatgcc gatcgccgct atgaaaccct ttctcaaggg gaaaaacaaa gagcattgat 1372261 tgctagagca ctaatggccg atccggagct gctgatactg gatgaaccag tcacaggact 1372321 ggattttatt gcccgggaaa agctgttaga tacgattaca tacattgcaa acaaagaaaa 1372381 tgcaccatct atcctttatg tgactcatca tgctgaagaa attttgcctg tctttgataa 1372441 agccctttta ttaaaacagg gagaggtttt tggatccgga gaaataaagg aaatgcttac 1372501 tgatcaaata ctttccgctt tttttgatac gccaatccat gtattatgga atcaggatcg 1372561 gccgttttta acaagagctg agccgataac gaatgcctga caaatatata tagattcatc 1372621 ctaggggtgc tttgcgaagc tgagagagac tttgtctcaa cccttttgac ctgatctgga 1372681 tcatgccagc ggagggaagc ggtgaaaagc ggagtacatc ggactccgtt tgtttttatt 1372741 aagccgtttc atcacatttg aaacggcttt tttgatttta aagaatagga gcggatttac 1372801 attggatcaa caaatatact ctttgcaaaa aaaagtggaa gaacataagg aggagcttat 1372861 tcagcttgcg aaaacgctga tttcttatca aacacctgct ccgcctgcaa gaaatacaga 1372921 gggcattcag tcttggattg cgggatattt aaatgaattg ggattctcga tcgacaaatg 1372981 ggatgtgtac cctggagatc ccaatgttgt agggaagcta aaaggaacag attcagcaga 1373041 ttattatagc ctgattatca atggccatgt agatgtggca gaggtaaaag aggatgaaga 1373101 atggaagcac gatccgtttc atcccattga aaaaaacggt ctcttaatcg ggcgaggcgc 1373161 ttccgatatg aagggcggaa tggcttgtgt gctgtttgct gtcaaattaa ttcgtgaagc 1373221 aagcattgaa cttccaggtg atctgattct gcaatcggtt attggggagg aagttggaga 1373281 ggccggcaca cttgaatgct gcaagagggg ctaccacgct gattttgcaa ttgtcgcgga 1373341 tacgagcgat atgcatattc aaggccaagg cggtgtcatt acaggctgga tcgaaatcaa 1373401 aagcagtcaa acatttcatg atggaacgag acggaatatg attcatgcag gcggaggaac 1373461 attcggagca agcgcaattg aaaaaatggc aaaaatcatt gcggggctcg gtgaacttga 1373521 gcgccactgg tctattatga aaagttatcc cggttttaaa ccaggcacaa atacgattaa 1373581 cccggcagtt atagaaggcg gcagacatgc ggcttttata gcggacgaat gccggctgtg 1373641 gatcacagtc catttttatc cgaatgaaac ccatgaccaa gtggcagcgg aaatagaaga 1373701 ttacgtcaat cggctgagtg acagtgatat ttggcttagg gaaaaccgcc ctgtattcaa 1373761 gtggggaggc tcatctatga tagaagacag gggagaaatt tttccggcat tggaagttga 1373821 ccctggccac ccaggcgtct tagcgctaac tgcctctcat cagaaagtga aacgggagtg 1373881 tccaattatt gacgtttctc aatcagttac agatggcgga tggctgtatg atgccggtat 1373941 tccatgcgta atatacggtc ctggagatct gcacaatgca cactctgtga acgagaaggt 1374001 atcgattgag cagctagtag agtatacaaa aattatactc gattttatca tcagctggtg 1374061 cagccggaaa aaagaacaat gacatgaaaa tttcttcttg ctgacaaggt tcagcctgcc 1374121 cgttcatata cttgaacaaa aggacggaaa aaggacgtga tggaatgatc agcatttcag 1374181 aatttcaggt aaaggatgtc gtcaatgtct caaacggaaa aaagctgggg agtattggtg 1374241 atattgatat caatgtgacc actggaaaaa ttcaggcgat catactcgga ggaaatggga 1374301 aagttctcgg attttttgga aaagaagagg aattggtcat tccatggcga aatatagtaa 1374361 aaatcgggga agatgtaatc ttagtccgat taagtgaacc acatgcataa acctgcttgt 1374421 ctgccgcaga ttggcaaatg ccggaagtct cgattcttcc ggcacatttc atttagaaat 1374481 atgcaaatcg gcgctcaacg aatgcagtaa gatgtggtaa aataagtggg aaattccgct 1374541 tttttaaatg tttgtcgaaa ggttggatca tcatgaatac atatcaccca ttcagtctta 1374601 ccacaccctc gacactcatg atacaagact gggctcaaac gaatcaaaac aacaaagagg 1374661 tcattgccgg atttacgaca aaaaacggcg gtgtcagcca aaagcctttt gaatcgttaa 1374721 atacaggatt gcacgttcat gacaaagatg cagatgtagt taaaaatcgt gaatatattg 1374781 ccgatatgtt taatactgat ttgcagtctt gggtattcgc tgatcagaca catgataatc 1374841 gcgttcagaa agtgacgcag agggataggg gaaaaggcgc ccgtgagtat cacacggctc 1374901 taaaagcaac ggacgggatc tatacaaatg aaaaaaatgt atttttagca ttatgctttg 1374961 ctgattgtgt gcctcttttc ttttatgatc cggttaagtc gcttgtcgga gtcgcccatg 1375021 ccgggtggaa aggcaccgtc aaacagattg gcagagaaat ggtgaagcaa tggactgaga 1375081 aggaaggttc aaatccctca gatatttacg ctgttattgg cccgtctatc agcggagcat 1375141 gctatacggt agacgaccgc gtcatggatg ctgtccgcgc attgccggtt tcagcagacc 1375201 ttgccgccaa tcagacggca aaggcacaat atcagcttga tctgaaagag ctgaaccgtc 1375261 ttatactgat ggacagcggt ttggcaagtg aacaaatttc tgtcagcggt ttatgcacgg 1375321 aaagcgagcc gtctcttttc tattctcatc gccgcgatca ggggaaaact ggacggatga 1375381 tgtcctttat cggaatgaag gaggcataaa agatcttgcg tgttgttgat aatttacgac 1375441 atataaacga acgaataaac gaagcatgta acagatcggg ccgcagctcc gatgaagtta 1375501 cggttattgc agtcacaaaa tatgtatcac ctgaaagagc acaggaggca gtagatgctg 1375561 gcatcacctg cctcggagag aatcgggatg cggaactgct ccgcaaacag gaattgatga 1375621 aagggaatcc ggaatggcat tttatcggca gtctgcaatc aagaaaagca aaatctgtcg 1375681 tcaattcggt ttcctatatc cattccctag accggctctc attagcgaaa gaaattgaaa 1375741 aacgggctga aggtactgta cgatgctttg tgcaggtcaa tacctctctt gagccttcta 1375801 aacatggcat gaaaaaagaa gaagtcattc cattcataca ggagctttcc ggtttcgaac 1375861 atatccttgt tgccgggctg atgacaatgg ctccgctgac tgatgatcaa gatcagatca 1375921 gaagctgttt caggtcgctg agagaactcc gtgaccaggt tcagaagctg aaccagccga 1375981 acgctccgtg tactgaactg tcgatgggca tgtcaaatga ttttgaaatt gcaattgaag 1376041 aaggagctac ttatattaga atcggctcat cgttagtcgg aaatgaaaca gggggtgtac 1376101 agcaatgagt atgaaaaata aactgaaaaa ctttttctca atggaagatg aagaatacga 1376161 atatgaatat attgagacag agcgggaatc tcatgaggag catgagcaaa aagaaaagcc 1376221 ggcttacaac gggaataaac ctgcgggcaa acagaatgta gtgagcttgc aaagtgttca 1376281 gaaatcctct aaagtggtgt tgagtgagcc gcgcgtttat gcggaggcgc aggaaatagc 1376341 cgaccatttg aagaaccggc gggcagttgt cgtcaatctt cagcggatac agcatgacca 1376401 ggcgaagcgg attgttgact ttttaagcgg aaccgtttat gccattggcg gcgatattca 1376461 aagaatcggc tcagatattt tcctctgcac gcctgacaac gtagatgtat caggcacaat 1376521 ttctgagctc atatctgaag acgaacatca gaggtggtaa agcgagatga tcctttatca 1376581 agttttttcg gttttaagct tattaatcac aatatactca tttgccctga tcatatatat 1376641 ttttatgtca tgggtgccga gtacgaggga aacagcagtc gggcgttttt tggcttcgat 1376701 ttgtgaacca tatctcgaac cattcagaaa aatcatccct ccgattgcaa tgctggatat 1376761 ttcaccaatc gtagcaatac ttgtgcttcg gtttgcgaca accggcttgt ggggacttta 1376821 tcgcatgatt gcgttttaat gtgacagttt gataggggct tggcagcagc caagcctctt 1376881 tacatagaag ggaaagacga tgagcgatat atatcagcac ttcagaaaag acgagcgggc 1376941 ctttattgat caagcgctcg aatggaaaag aattgtccag gagcagtacc ggatgaagct 1377001 gaccgacttt ttagatcccc gagagcaggt catcctctct gctgttacgg gacaggcaga 1377061 tgtcgggctt gccttttccg gcggctatga cagagcggag cggaaacggg cgattctgtt 1377121 tccagagtac attactccgg aagaatcaga ttttgaactg caggcgttta acgtccgtta 1377181 tgctgacaag tttgtctcag tagatcatcg ttctctgctt ggtgcattaa tgggcatagg 1377241 attaaagcgg caaaaattcg gtgacatcgt gttttctgag acagcagtgc aattgattgt 1377301 ctcagccgat accgctgatt ttgtggctgc acagctgacc caagcaggca aagcggcggt 1377361 cagcctagag aaaatcgact tgtcagacct taacattcca gcagttgatg tcgaaataag 1377421 agatgacacg gtttcttctt taaggcttga cgccgtctgc gcctctatga gcaggcaatc 1377481 ccgccagaaa tcacagacgc ttgtgaaaaa cggccttgtg aaagtgaact ggaaggtggt 1377541 tgaagatcct tcatacatag tcgcggaagg ggacatgctg tctatcagag gttttggccg 1377601 gtgcagctta acaaaaatcg aaggaaaaac caaaaaagac aaatggagag ttacgtttga 1377661 acgacaaaaa tagtcggttt ttcagttttt ttctccatct gtgcgaaatt tgttttataa 1377721 tgtgaactag ataaccgtac tgaaatgtaa aaatggaggt ggcatcatgc cattaacgcc 1377781 aaatgatatt cacaacaaga cgtttacaaa aagttttcgc ggatatgatg aagatgaagt 1377841 aaatgaattc ctagcccaag tcagaaaaga ttacgaaatt gttctccgca agaaaactga 1377901 gcttgaagcg aaagtcaatg agcttgatga aagaatcgga cactttgcca atattgagga 1377961 gacattgaat aaatcaattt tagttgctca agaagcggct gaagacgtaa aacgcaattc 1378021 tcaaaaagaa gcaaagctga tcgttcggga agcggagaaa aacgctgatc gcattatcaa 1378081 cgaatcgtta tcaaaatcaa gaaaaattgc aatggaaatt gaagagctga aaaaacagtc 1378141 taaagtgttc agaacacgtt tccaaatgct gattgaagct cagcttgatc ttctgaaaaa 1378201 tgacgattgg gatcatctcc ttgagtatga agtcgacgct gtatttgagg aaaaggaata 1378261 aattctctga ttatcttgac attttcttag cttgtcgaat ataatacgtt cataaattca 1378321 gatgaaaaaa cggttgaaag ggacagtcat gtttccttca ggccttcata gcgacccgga 1378381 gatggtgaga gtccgggatg gccggaatca tgtagatcag ccctttagtt tccttgctga 1378441 actcacagta ggttaggacg ttcatcacgt tacgatgctc aagaggaaaa agtgtatgct 1378501 tgctttttct aaaagggtgg taccgcgaga taagctttct cgtcccttat gggatgagag 1378561 ggcttttttt attttctgaa aaaatgcagt ggaggaatga aaatggattt taaagacacg 1378621 ctcttaatgc cgaaaacaga tttcccgatg cgtggaaatt tgccaaaccg tgagcctgac 1378681 attcaaaaaa aatgggagga agaagatatc taccgtcttg ttcaggaacg gacgaaagac 1378741 cgcccgaaat ttgttttaca tgacggacct ccgtatgcaa acggcgacat ccatatgggc 1378801 catgcactta acaagatttt gaaagacttc attgtccgct ataaatcaat gagcggctac 1378861 aacgcaccgt atgtgccggg ctgggataca cacggattgc caattgaaac agctctgaca 1378921 aaaaacaaaa aggtcaaccg caaagaaatg tcagtagcgg aattccgcaa actatgcgaa 1378981 gagtacgctt ggaagcaaat cgagggacag cgtgagcaat tcaaacgtct tggtgtccgc 1379041 ggtgactggg aaaacccata tgtgacatta aaaccggaat acgaagcgca gcaaatccgc 1379101 gtatttggtg aaatggcaaa acgaggctac atttacaaag gccttaaacc ggttaactgg 1379161 tcaccttcaa gtgagtctgc tctggctgaa gccgagatcg aatatcaaga taaacgttca 1379221 gcatctattt acgtcgcttt tggtgtaaaa gacggaaaag gcgttcttga aaacggcgag 1379281 cgcatcatca tttggacaac aacgccgtgg acaattccgg cgaacctcgg aatctcagtg 1379341 caccctgatc ttgagtacag cgtgattgca gtaggtgaag accgctttgt tgtagcaagt 1379401 gccttagtcg aaaatgttgc atcggcatgc ggatttgatc agtatgaagt gacaagaacg 1379461 gtcaaaggga aagaccttga gaacattatc gctgaacacc cgctatatgg cagagactct 1379521 ctcgttatgc ttggtgaaca cgtaacaact gatgccggaa caggctgtgt tcatacagcg 1379581 cctggacatg gggaagatga ctttatcatc ggccaaaaat acggtttaga tgtgctttgc 1379641 ccggtcgatg aaaaaggtgt aatgacaagc gaagctcctg gctttgaagg catgttctat 1379701 gatgatgcaa acaaagcgat cacacagcag cttgatgaaa aaggcgcact tgtgaagctt 1379761 gaattcatta ctcattctta tccgcatgat tggagaacaa aaaaaccaac cattttcaga 1379821 gcaacagcgc aatggtttgc gtctattaaa gatttcagat cagacctgct ggatgccatt 1379881 aaagaaacca aatgggttcc tgaatggggc gagcagcgtt tgcacaacat ggttcgggac 1379941 cgcggagact ggtgtatttc cagacagcgt gcgtggggtg tgccgattcc ggtattttac 1380001 gctgaaaacg gagaaccggt tattacagat gaaaccattg aacatgtttc tgaattgttc 1380061 agacagcatg gatcaaacat ttggtttgaa aaagaagcaa aggatcttct tccggaaggc 1380121 tttacgcatc ctggcagccc gaacggcaca tttacaaaag aacaggatat catggatgtt 1380181 tggtttgatt caggctcttc acatcaagca gtgcttgaag aacgtgatga cctcgttcgc 1380241 ccggctgatc tatacctaga gggatctgac caatatcgcg gctggtttaa ctcttctctt 1380301 tctacagcag tagccgtaac agggaaagcg ccgtataaag gtgtgctcag ccatgggttc 1380361 gcactggatg gagaaggacg taagatgagt aaatcaatcg gtaacgttgt tgttccggct 1380421 aaagtcatga aacagcttgg tgccgacatc ttaagattat gggtatcttc agtggattat 1380481 caggcggacg ttcgcgtgtc tgacgccatt ctgaagcagg ttgcggaagt atatcgtaaa 1380541 atccgcaaca cgttccgttt ccttcacggc aaccttttcg attttgatcc aaaaacaaat 1380601 gcggtggctg tcgaagatct tcgcgaagtg gatcagtata tgctgattaa gctgaacaag 1380661 ctgattgata aagtgaaaaa agcgtatgat gagtacgaat ttgcggttgt gtatcacagc 1380721 attcataatt tctgcacaat cgaattgagc tcattctacc ttgattttgc aaaagatatt 1380781 gtctacatcg agcatgcgga tcatccggat agacgcagca tgcagacagt attctacgaa 1380841 acgcttcttg cattagtgaa gctttcagcg cctatccttc cacatacggc agacgaattg 1380901 tggtctcatt taacatttgt tgaagagcag agcgttcagt tgaccgatat gccggaaaca 1380961 atcacggttc caaacagtga agcgactgaa gaaaaatttg accgctttat ggctcttcgt 1381021 gatgacgtgt taaaagcatt agaaactgcg cgaaatgaaa aaattatcgg taaatctttg 1381081 gaagcaaacc tgaaattgta tccaaacaaa gaaaacaagg agctcttggc ttccataaaa 1381141 gaaaaccttt ctcagctgtt tattgtgtct gaactgacaa tcagcgaaga aaatgaagcg 1381201 ccgaacgatg cgcaaagctt tgcgacgggt aaaatcgctg tcgagaaagc ggaaggcgaa 1381261 atgtgtgaga gatctcgtgt gatttcaaaa gatgtagggg caaatccgaa atatcctaca 1381321 ctttcattac gcaacgctga aatcgttgaa aaatactatc aaaaataatg caaaagagcc 1381381 cggcgtaaaa gccgggcttt ttttgtgcca agagtgacat cctttagaac gaaaggaaaa 1381441 atcttatggg ctttagatca tcattcacag gcaacaataa agatactacg ttaagagcag 1381501 gagttgtgaa gaatgaatga tcaactgacc gcaatttata cggaacttct tctgatgaaa 1381561 gaagaattac agtcgagatt atttgagtat tcttgctttc aggtttctac aagcccgcaa 1381621 gcagcaatca atcaaaaaca aaaagcaact ctgatctatc atattaaaga agaacttcaa 1381681 gacgttctcc ttgcattgtc caaaatcgaa aacggcacat tcggatactg tgaagaaact 1381741 ggggccccca ttcctcttgc aaagctggca gtgctgccga cggcccgaac agcaaacgat 1381801 tttctttatt ctgtccaatt tgagaaaaaa acgcttccga tatggaaatc aacggatatc 1381861 gaatatggtc aggcactgta tgaataacag tgtctgtccg gttaatatgc ctgatatttc 1381921 tttactccag tgctttttat tgataaaatg cataatggat taaagtaacc gtaaactgga 1381981 ggaacgtttg tgctgtatta tatgattgca ctacttatta ttgcagccga tcaattgaca 1382041 aaatggctag ttgttaagaa catggaactt ggccaaagca ttccgatcat tgatcaggta 1382101 ttctatatca cctcccatcg caatacgggt gctgcatggg ggatattagc gggtcaaatg 1382161 tggtttttct acctcataac aaccgctgtt attattggta ttgtttatta catacagcgt 1382221 tatacaaagg gacaaaggct tcttggcgtt gccctcggac ttatgcttgg cggtgccatc 1382281 ggcaacttta tcgatcgggc tgtcagacag gaagttgtgg attttatcca tgttattatt 1382341 gtcaattaca attacccgat atttaacatc gcggactctt cactatgtgt cggcgtaatg 1382401 cttttattta tacaaatgct gttggacagc gggaaaaaga aaaaggagca atagcatgaa 1382461 tcaaattgat ataaccgctt cagaagaaca aaaaagtgag cggattgata aatttttggc 1382521 atcgactgag aatgattggt caagaaccca ggttcagcaa tgggtaaaag acggacaggt 1382581 tgtcgtgaac ggaagcgcgg tgaaagcgaa ttataaaatt cagccgggtg atcaggtgac 1382641 cgtcactgta cctgaaccgg aagcgctcga cgtcctggca gagcctatgg atctggatat 1382701 ttattatgag gaccaggatg tgctggtcgt caacaaacct cgcggaatgg ttgttcaccc 1382761 agcacccggg catcttacgg gcacacttgt aaacggtctt atggctcatt gcacagacct 1382821 ttccggaata aatggtgtga tgcgcccggg tattgttcac agaatcgata aggacacgtc 1382881 cggtttatta atggtggcga aaaatgatat ggcgcacgag tcactcgtaa accaattggt 1382941 caacaaaacg gtcacgcgga aatatacggc ggttgtccac gggcttattt ctcatgatga 1383001 cggcacaatt gacgcgccga tcggacggga taaaaaagac cgtcaaagca tgactgtgac 1383061 acgtgatggc aaaaacgctg tcactcattt tcatgtgctt gagcgttttc aggattttac 1383121 gttagtggag tgccagcttg aaacagggag aacccatcaa attcgtgttc atatgaaata 1383181 tatcggattc ccattagcag gcgatccgaa atacggccca agaaaaacaa tcgactttaa 1383241 tggccaagcg cttcacgcgg gagttttagg ttttgaccat ccacgaacag gagaatatgt 1383301 cgaatttgaa gcgccgcttc ccgaggatat ggcagaatta atcgaaaacc tcagaaaaaa 1383361 cggttgacag agggtttctt ttctgaaata ataaacgaag ctgaatagat tctttaaaac 1383421 agtccagaga ggctgagaag gataacggat agacgggatg cgtgtatagg cgcgcacctt 1383481 gtcctaaaac ccctctatgc tctggcagga ggggtttttt cttctatatg aactgtgagg 1383541 tgtcacacat tgaatcaaaa agctgtcatt ctcgacgaac aggcaattag acgggcgctg 1383601 accaggattg ctcacgaaat gatcgaacgc aataaaggaa tgaataactg cattcttgtc 1383661 ggcattaaga caagagggat ttacctggca aaacgccttg cggaacgcat tgaacagatt 1383721 gagggaaatc ctgttacagt cggtgaaatt gatattactc tttacagaga tgatctttct 1383781 aaaaaaacaa gcaacgatga accgcttgta aaaggtgcag atattccggt agatattaca 1383841 gatcaaaaag tcattctcgt tgatgatgtt ctgtataccg gaagaacagt cagagcagga 1383901 atggatgcgc ttgttgatgt aggcagacct tcctccattc agcttgcagt gcttgtggac 1383961 agaggacacc gggagctgcc gatccgagcg gattatatcg ggaaaaacat cccgacatca 1384021 aagtctgaaa aggttatggt acagcttgat gaggtagacc aaaacgatct cgtcgccatt 1384081 tatgaaaacg aataatagat caccttttta agggcaatcc agagaggttg caaagaggtg 1384141 cacaacaaag gcccaaaaag tattcggcag gtctttgtat gcctctttgc gtaaaaaagc 1384201 aaagaggttt ttttatacag tcattgagtc atcctaaaat gaaagtcaac aatcaggggg 1384261 aaatcatcat gagtaagaaa aaagtaaatt taggggtcag ggatgtcccg acacctttct 1384321 cttgggtttc attcagcctt cagcatttgt ttgccatgtt tggctcaacc attttggttc 1384381 cgaagctcgt cggaatgagt cctgctgtgg cgttggtgac aagcggcatc ggaacactgg 1384441 cgtaccttct tattaccaaa ggacaaattc cggcgtatct cggttcatcc ttcgccttta 1384501 tttctccgat cattctggta aaagcgaccg gcgggccggg agcggcaatg gttggagcgt 1384561 ttcttgcagg gctggtgtac gggctgattg ccttattgat taggcagctt ggaacaggat 1384621 ggctgatgaa gattctcccg cctgtagtcg tagggcctgt tattatcgtc atcgggctgg 1384681 gactggcaag cactgcagta aacatggcga tgtatgctga tccgaacgcg agtgagttgg 1384741 tctacagctt aaagcacttt agtgtcgcag gagttacgct ggcaattacg attatttgtg 1384801 cgattttctt acgagggttt ttaagcctga ttccggttct gatcggaatc atcggcggat 1384861 acctgtttgc ccttactcaa gggattgtca acttccagcc ggtgcttgac gcgaaatggt 1384921 ttgcagtgcc tgaatttatc attccgttca aagattattc accgtcagtt acgctcggca 1384981 tcgcagccgc aatggttcct gtcgcatttg tcacaatgtc agagcatatc ggccaccaaa 1385041 tggtgctgag caaggttgtc ggacaagact tcattaaaaa gccaggtctt catcgctcta 1385101 ttatgggtga cagtgtggcg acaatcctcg cttccctgat cggcggccct ccgacaacga 1385161 cttacggaga aaacattggc gtgctggcca tcacaagagt attcagcgtc tttgtcatcg 1385221 ggggcgcggc agtgattgcc ctttgcttcg gctttatcgg caaaatttca gcgctgatca 1385281 gttcagtgcc gtcagcggtc atgggaggcg tctccttcct gctgttcgga atcattgctt 1385341 caagcggcct gagaatgctg attgacaaca aaattgatta tgaaaacaac agaaacctca 1385401 ttattacatc agttatcctt gtcatcggtg taggaggcgc ttttatccaa gtgtctcagg 1385461 gcggattcca agtgtcagga atggcgcttg ccgcaattgt cggtgtcatc ttaaacctga 1385521 ttcttccgca ggcgaaggaa gagcaggcag acacatctga acaacatcat atttaaaacc 1385581 ttttaatgaa agtccagaga ggcttggaag ggttatgaag agaaggaagc ttcaatgctg 1385641 ccctctattt aaccataccc cgagtctatc ttagaccggg gttttttttc agccttaagt 1385701 tgaaaagaga ggggaaagaa catgaagcat ttaacgacga tgagtgaact tagcactgag 1385761 gaaatcaaag atttgcttca aacagcacaa gagctcaaaa gcggaaaaac agacaatcag 1385821 cttacaggaa agtttgcagc aaacctgttt ttcgaaccga gcacgagaac gcggttcagc 1385881 tttgaggtcg cagaaaaaaa gctgggcatg aatgtgctta accttgatgg aacaagcaca 1385941 agcgtgcaaa aaggcgaaac cttatatgac acgatccgga cgcttgaatc aatcggtgtg 1386001 gacgtctgcg tcatcaggca cagtgaggat gagtattatg aagagcttgt cagccaggtg 1386061 aacattccga ttctgaatgc gggagacggg tgcggccagc atccaacaca atcactgctt 1386121 gatttaatga cgatttatga agagttcaat acgtttaaag ggcttaccgt ctccattcac 1386181 ggcgacatca agcatagcag agtggcaagg tcaaatgcgg aagtgttgac aagattgggt 1386241 gcccgggtcc tattttccgg cccttcggaa tggcaggatg aagaaaatac attcggcacg 1386301 tatgtctcaa tggatgaagc agttgagtct tccgatgttg tcatgctgct gcgcattcaa 1386361 aatgaacgac atcagtccgc tgtcagtcag gaaggctatt taaacaaata cggcttgacc 1386421 gtagaacggg ctgagcgtat gaagcggcat gcgatcatca tgcatcctgc tccggtaaac 1386481 agaggagtgg agattgatga cagcttagta gaaagcgaaa aatcaagaat cttcaagcaa 1386541 atgaaaaatg gcgtatttat cagaatggca gtgatacagc gtgccttaca aaccaatgtg 1386601 aaaagaggag aagcagcgta tgtcatatct cattaaaaac ggctggatac taaacgaaaa 1386661 tggtgaaaaa acacaagcgg atatccgagt gactggagaa accatcaccg caatcggcaa 1386721 gcttgatgca acggataatg aaacggtaat tgatgcaaaa ggtttgctcg tttcacctgg 1386781 gtttgttgat ctccacgtgc atttcagaga gccgggcgga gagaaaaaag aaactattga 1386841 aaccggggca aaagcagcgg cgcgcggcgg ctatactaca gtagcagcaa tgccgaatac 1386901 gcggccggtt cctgatacaa aggagcagat ggaatgggtg caaaacagaa ttaaagaaac 1386961 atcatgcgta agagttcttc catatgcatc cattacgatc agacaaatcg gcgatgaaat 1387021 gacaaacttt gaagcgttaa aagaagccgg ggcatttgct tttacagatg acggcgttgg 1387081 tatacagaca gcaggaatga tgtatgaagc gatgaaacgg gcagccgcaa ttgacaaagc 1387141 gattgttgca cattgcgagg acaactcctt aatttacgga gggagcgtac atgaggggac 1387201 attctccaaa gcgaacgggc taaacggcat tccttctgtg tgtgaatcgg ttcatattgc 1387261 tcgcgatgtg ctgctggctg aggcggcaaa ctgccattat catgtatgcc atatcagcac 1387321 aaaagaatct gtcagagttg tacgcgatgc gaaaaaagcg ggaatcagag tgacagcaga 1387381 agtatcgccg catcatttgc tgctttgtga tgaggacatc ccggggctgg acacaaacta 1387441 taaaatgaat cctccgctcc gcagcccaga agacagagct gctttaattg aaggtctttt 1387501 agacggaaca attgatttta tcgcaacaga ccatgcaccg catacggaag aagagaagaa 1387561 cacagaaatg aagctggcgc cattcggaat tgtcggctta gaaacagcat tcccgcttct 1387621 ttacacacac tttgtcaaaa atggcagctg gtcactgaag cagctgattg actacatgac 1387681 aatcaagcca tgcgaagcgt tcggtctccc atatggaaca ttacaaacgg ggcaagctgc 1387741 ggacattacg ttaatcgatt tagaaaaaga agcagttata gacaaagaga catttttatc 1387801 aaaaggaaaa aatacaccat tcaacggcat cagttgcacc ggctggccgg tcgctacaat 1387861 tgcggcaggg aagcttgctt atgaagaggg gagacttgtc aaatgaagag acgattagta 1387921 ctggaaaacg gagcggtatt cgagggagaa gctttcggaa gcttagaaca caacatggga 1387981 gaagtcgttt ttaatactgg gatgacaggc tatcaggaaa ttttatctga tccttcttac 1388041 tgcggacaga tcgtaacatt aacatacccg cttatcggaa attacggcat taaccgtgat 1388101 gattttgaat ccattacccc ttttgtcaaa gggctgatca tcaaagaatt atgtgagctg 1388161 ccttccaact ggcgttcagc atacacctta gacgagtatt taaaaatgaa aaacattccc 1388221 ggactccagg gaattgatac aaggaagctg acaagaatga tccgcacggc aggcgcgcta 1388281 aaaggaacat tcgcttcatc tgatgaagat atcgaagcag tgctgaaaag actgaacgaa 1388341 acggaattgc caagaaatca agtatcccaa gtatcagcaa aaacagcata tccgagcccg 1388401 ggaagaggca aacgcattgt cttggttgac ttcggcatga aacacgggat tctaagagag 1388461 ctgaacaaac ggaaatgtga cgtcatcgtt gtgccttaca acattacagc ggaagaggtg 1388521 cttcagctga aaccggacgg tatcatgctt tctaacggac ctggagaccc gaaggatgtg 1388581 cctgaagcga ttgaaatgat taaaggtgtt cttggaaaag tgccattatt cggaatatgt 1388641 ctcggccacc aattattcgc gctggcgtgc ggggcgaata ctgaaaaaat gaaattcggc 1388701 cacaggggct caaaccaccc ggtaaaagag ctggctacag gaaaagttgc cttaacatct 1388761 caaaaccatg gatatacagt ttcgtctatc agtaaaacag aactggaagt gacgcatatc 1388821 gcaattaacg acgatacgat tgaagggctg aagcataaaa cattgccggc atttacggtt 1388881 caatatcatc ccgaagcctc acctggtcct gaggatgcca accatctatt tgacagattc 1388941 atcgaaatga tcgaaacaac agagaaagaa ggggaagcgg tatgccaaaa cgcgtagaca 1389001 ttaacaaaat tttagtaatc ggatctggac cgatcatcat cggccaagca gcagaatttg 1389061 actatgcggg aacacaagcc tgtcttgctt tgaaagaaga aggctatgaa gtcatccttg 1389121 tcaactcaaa ccctgcaacg atcatgacag atacagaaat ggctgaccgg gtttacatcg 1389181 aaccgctcac acctgaattc ctgacacgaa tcatcagaaa agagcgcccg gatgccattc 1389241 ttcctacact cggaggccaa accggtttga atcttgcggt tgagctttct gaaagaggcg 1389301 ttttggcaga atgcggcgtc gaagtgcttg gcacgaaact gtctgcgatt cagcaagctg 1389361 aagaccgtga cttgttcaga acattaatga atgaactgaa tgaaccggtg cctgaaagtg 1389421 agattatcca ctcccttgaa gaagcagaaa aattcgtcag tcaaattgga ttccctgtca 1389481 ttgtccgccc ggcatataca ttaggcggaa caggcggagg catctgctcg aatgaaacag 1389541 agctaaaaga aatcgttgag aacggcttga aattaagccc ggtacaccaa tgtctgcttg 1389601 aaaaaagcat cgccggctat aaagaaatcg agtatgaagt catgagagac agccaggatc 1389661 acgccattgt cgtttgtaac atggaaaaca ttgatccagt tggaatccat actggagaca 1389721 gtattgttgt cgcgccgagc caaacgctca gcgatcgcga atatcagctc ttgcggaatg 1389781 tatcgttaaa actgattcgc gcgcttggga tcgaaggcgg atgtaatgtc cagctcgcct 1389841 tagatccaga cagcttccaa tattacatta ttgaagtaaa tccgcgtgtc agccgttcat 1389901 ctgcccttgc atcaaaagca acggggtacc cgattgcaaa gctcgctgct aaaattgcag 1389961 tcggactttc attagatgaa atgatgaacc cggtgacagg aaaaacatat gcagcatttg 1390021 aacctgctct tgactatgtc gtatccaaaa ttccgcgctg gccgtttgat aagtttgaat 1390081 cagcaaacag aaagcttggc acgcaaatga aagcgacagg tgaggtcatg gcaatcggcc 1390141 gcacgcttga agagtcattg ctgaaggcag tgcgatcact ggaagcggat gtgtatcatc 1390201 ttgaattgaa ggacgccgct gacatttcag atgagcttct tgaaaagcga attaaaaagg 1390261 ccggtgatga acgcttattc tacttagctg aagcgtacag aagaggctac acggtagaag 1390321 acctccatga attttccgct atcgatgtct tcttcttgca taagctgttc ggaatcgtac 1390381 agtttgaaaa agaattgaag gccaatgcgg gcgatacaga tgtgctgaga cgggcaaaag 1390441 aactcggctt ctctgatcag tacatcagcc gtgaatggaa aatgaaagaa tctgagcttt 1390501 acagcttgag aaaacaagcg gggattgcgc cggtattcaa aatggtagat acatgcgcgg 1390561 cggaatttga gtcagaaacg ccatacttct atagcacata tgaagaagaa aatgaatctg 1390621 tcgttacaga taagaaaagt gtgatggtgc ttggttcggg tccgattcga atcggtcagg 1390681 gtgtcgagtt cgactatgcg acggttcact ctgtatgggc aattaaacaa gcaggctatg 1390741 aagccattat tgtcaacaac aacccggaaa ccgtttcaac agacttcagc atctcagaca 1390801 agctgtattt tgaaccgctt acgattgaag atgtcatgca catcattgac ctcgaacagc 1390861 caatgggcgt tgtcgtacaa tttggcggac aaactgcgat taaccttgct gacgagcttt 1390921 ctgcacgcgg agtgaaaatc cttggaactt cattagaaga tttagaccgt gccgaagacc 1390981 gggataaatt tgaacaagcg cttggagaac ttggtgttcc tcagccgctt ggcaaaacag 1391041 cgacatcagt taatcaggcg gtaagcatcg caagtgatat cggttatccg gtactggtac 1391101 gcccttccta tgtacttggc ggccgggcga tggagattgt ttaccatgaa gaggaactgc 1391161 ttcattacat gaaaaatgca gtcaaaatca atccacagca ccctgtatta attgatagat 1391221 acttgaccgg aaaagaaatt gaagtcgatg cagtatccga cggtgaaaca gtcgtcattc 1391281 cgggaattat ggagcacatt gaacgtgcgg gcgttcactc cggagactca atcgctgttt 1391341 atccgcctca gtctctcaca gaggacatta agaaaaaaat tgaacaatac acgatcgcat 1391401 tggctaaagg gctgaatatt gtcggtttgc tcaatattca attcgtcttg tcgcaaggcg 1391461 aggtgtacgt gctagaagtg aatccgagat caagcagaac cgtaccgttt ttaagcaaaa 1391521 ttacgggtat cccaatggcg aatctcgcaa caaaaatcat tcttggtcaa aagctggctg 1391581 cgtttggcta tacagagggc cttcagcctg aacagcaagg tgtatttgta aaagcgccgg 1391641 tcttctcctt tgccaagctg agaagagtgg atattacgtt agggcctgaa atgaaatcaa 1391701 caggtgaagt catggggaaa gattcgacac ttgaaaaggc gctctacaaa gccttgatcg 1391761 cttcaggtat tcaaatcccg aactacggtt ccgtgctttt aacagtagct gataaggaca 1391821 aagaagaagg gcttgccatt gctaagcggt tccacgcgat cggctacaac attttagcga 1391881 cggaaggaac ggcaggctac ctgaaagaag cttccattcc agcgaaggtc gtcggaaaaa 1391941 tcggtcagga tggcccgaac ttgcttgatg tcatcagaaa cggagaagcg cagtttgtca 1392001 tcaatacgct gacaaaagga aagcagccgg caagagacgg ttttagaatc agacgtgaat 1392061 cagtagaaaa tggtgttgcc tgcctaacat ctttagatac ggcagaggcg atattgcgag 1392121 tgctggaaag catgacattc cgtgctgatc aaatgccggc agtcaacaca aatcaggagg 1392181 cggcagtcac tatatgaaaa aagcgtattt gacagtatgt tctaaccagc aaattgcaga 1392241 ccgggtgttt caaatggttc tgaaagggga gcttgtccaa gggtttacaa cccctggaca 1392301 gttccttcat cttaaagtga gcgaagcggt tacgcctctt ttgagaaggc cgatcagcat 1392361 cgcagacgtc aactttgaaa aaaatgaagt caccatcatt tatcgggtag atggggaagg 1392421 gacaagactc ttgtcactga agcagcaggg agaacttgtg gatgtcctcg ggcctttggg 1392481 aaatggcttt cctgttaatg aagttcaacc cggaaagacg gctttgctgg taggaggcgg 1392541 agtaggtgtg ccgcctctcc aagagctgtc gaaacgcttg attgaaaaag gggtaaatgt 1392601 catccacgtt ttaggattcc aatcggcaaa ggatgttttt tacgaggaag aatgccggca 1392661 gtacggagac acgtatgtgg caacagctga cggaagctac ggggaaaccg gatttgtcac 1392721 agatgtgatt aaacggaaaa agctagagtt tgatatcctc ctcagctgcg ggccgacacc 1392781 gatgctcaag gcgttaaaac aggaatatgc ccataaagaa gtatatctgt ccatggagga 1392841 acgaatgggc tgcggaatcg gcgcatgctt cgcgtgtgtg tgccatacaa acgaaagtga 1392901 gacatcctat gtaaaagtat gtctcgacgg gcctgtattt aaagctcagg aggtggcgct 1392961 gtaatgctag aggtgaaatt gccgggactt gatttgaaaa acccaatcat tcctgcatca 1393021 ggctgcttcg gttttggaaa agaattttca cgtttttatg atttgtcttg tcttggagct 1393081 atcatgatta aggctacgac aaaggagccg cgctttggga atccgacgcc gcgggtagct 1393141 gagactggtg ctggaatgct caatgcgatc ggtctccaaa atccggggct ggatagtgtg 1393201 ttgcatcatg agctgccgtg gcttgagcag tttgatacac cgatcattgc caatgtcgca 1393261 ggttctcaag tcgatgatta tgttgaagtc gcagaacata tcagcaaagc gcctaatgtt 1393321 catgctcttg aattgaatat ttcctgcccg aatgtgaaaa caggcggaat cgcttttggc 1393381 acgaatcctg aaatggctgc cgatttgaca aaagcggtga aagaggtttc ggatgtaccc 1393441 gtttatgtga agctatcccc gaacgtggct aatatcacag aaattgcatt agcgatcgag 1393501 gaagcgggag cggacggtct tacgatgatc aacacactaa tcggcatgag actcgattta 1393561 aaaaccggca aaccgatatt agcgaataaa acagggggac tttcgggccc tgctgtgaag 1393621 ccggttgcca ttcgcatggt gtatgaagtc agccagatgg tcaacatccc gattatcgga 1393681 atgggaggcg tgcaaacggc tgaagatgcc ctggaatttc ttctcgcggg agcaagcgca 1393741 gtcgctgtcg gaacagcaaa ctttgtgaat ccttttgcat gtccagagat tattgaacag 1393801 ctcccatctg ttttgctcca atacggctat caatcaattg aagaatgcat cggaaggagc 1393861 tggaatcatg aaaaacaacc tgcccatcat cgcgcttgat tttgcgtcag ctgaagaaac 1393921 acttgcgttc ttagcgcctt ttcagcaaga accgttattt gtaaaggttg ggatggagct 1393981 tttttatcaa gaagggccat ctatcgtgaa acaactaaaa gaaagaaact gcgagctatt 1394041 tttagatcta aagcttcatg acatcccgac tactgtaaac aaagcgatga agcgccttgc 1394101 cagtcttgga gtagacctcg tcaatgttca tgctgccggg ggcaaaaaaa tgatgcaggc 1394161 agctctcgaa ggcttagaag aaggtacgcc ggctggaaaa aaacgtccgt cacttatcgc 1394221 ggtaacccag ctgacaagca catctgaaca aatcatgaaa gatgaactgc tgatcgaaaa 1394281 gtctctgatt gatacggttg tgcactacag caaacaggcg gaagaaagcg gactggatgg 1394341 agtggtctgc tctgttcatg aagcaaaagc catttaccaa gcggtgtcgc cttcatttct 1394401 gactgtcact ccggggatca gaatgtcaga ggacgctgcg aatgaccaag ttcgcgtagc 1394461 gacgcctgcc attgcaagag agaaaggttc atcagcgatt gtagtaggac gctcgattac 1394521 aaaagcggaa gacccggtaa aagcctataa ggctgtcaga cttgaatggg agggaatcaa 1394581 atcttgaaac aaatcatcgc aaaacatcta ttagacatcc aagctgtatt tttacgcccg 1394641 aacgagccgt tcacatgggc aagcggcatt ttatcaccga tctactgtga caaccgcctt 1394701 acgctatctt tcccagaggt cagaaacgat gttgcttcag gtatcagcaa gcttgttaaa 1394761 gagcattttc ctgaagctga aatgattgcg ggaacagcaa ctgccggtat tcctcatgct 1394821 gctcttgcgg cggaccattt gaatcttccg atgtgttatg tgaggagcaa gccgaaggcg 1394881 cacggaaaag gcaatcagat tgagggagct gtgcaagaag ggcaaaaaac agtcgtcatt 1394941 gaagacttaa tttccacagg aggcagcgtg cttgaagctt gtgcagcttt acaagcggcc 1395001 ggctgtgaag tgcttggtgt cgtctcaatc tttacgtacg gacttcctaa agcggaggaa 1395061 gccttcgcaa aggcagaact gccatactac tcattaaccg attatgatac gctcacagag 1395121 gtcgcgcttg aaaacggaaa tattcattca gatgatctaa aaaagctgca aacatggaaa 1395181 cgaaatcccg agtcaaaaga ttggtttaaa aaataaaaaa taaattcaaa tgatgtaaag 1395241 aggcttcaaa gccttgctgt acttgaaaac aggctgtgag gcctgttttt ttattaatcc 1395301 tataaaaaaa gtcgggttga cttatgttag aattgtgcta aaatttacta caaatctaaa 1395361 aacttatcaa gagcggctga gggactggac ctatgaagcc cggcaacctg catagtttgt 1395421 aaggtgctac ttccagcaaa atgaattcca ttttgaaaga taagggctgc atgctgttcc 1395481 tgtctttctt tccgccggat tgaaagtttt ttattttaag aggtaaaaag gctatctgta 1395541 tatcagcagc cgcgaatcac attacatggg aaaagacaac cggcagaaag ctactgtttg 1395601 tttgtctccg aaaggaggaa agaagaaatg ttaacgtatg ataattggga agaaccaacg 1395661 attacatttc cggaagacga tccttataaa ggagcgctgt cagttttaaa atgggcatac 1395721 ggccattacg gcgatcagct tgtttatgcc tgcagtttcg gaattgaggg aatcgttctg 1395781 attgacttaa tttataaagt gaaaaaagac gcagagattg tgtttcttga tacaggactt 1395841 cattttaaag aaacctatga aacaattgaa cgagtgaaag agcgttatcc gggtcttaat 1395901 atcatcctga aaaaaccaga tctcaccctt gaggaacaag ccgaagaaca tggtgacaaa 1395961 ctatgggaaa gagagccgaa tcagtgctgc tatcttagaa aggtcgttcc tttaagagag 1396021 gcgctttcag gacatccagc ctggctttcc ggcctgcgcc gtgatcaagg gccaagccgt 1396081 gccaatacga atttcttaaa caaagatgaa aaattcaagt cagtaaaagt ttgcccgctt 1396141 atccattgga cttggaaaga catttggaga tatacatccc ggaatgaact ggactacaat 1396201 ccgcttcatg accaaggcta tccaagtatt ggctgtgcgc cttgcacttc tcccgctttt 1396261 acagcagaag atttgcgctc aggcagatgg aatggtatgg cgaaaacaga atgcggactg 1396321 catgaataag gagctgcaaa atggaattag ccgctatttt atttagcttg tttttcgcga 1396381 tgaatattgg tgcaagcggc gctgcagctt cgatgggggt tgcttacggc tccggagcca 1396441 tcaaaaagaa aacttacgct ttgatcctat gcgcagtcgg tgtctttgcc ggggcggtca 1396501 ttggcggagg cgaggttgta aaaacaatca gctccggcat tattcctgag cagacgatta 1396561 cactgacgat tgtttgcatc attattggag ctgctgccct gtcgctcttt actgctaatc 1396621 tgctcggcat tcctttgtcg acaagtgaag taacagtcgg cgcggttgtc ggcgtgggag 1396681 tggcttataa agtattgttt gtgaacaatc ttctgatcat tgtgtcattt tgggtttttg 1396741 tcccgctgtt cgctttcggc ttcacctatt tcgtatctaa gctgtttcgt tattttaaga 1396801 ttgaagtaaa atcttctaaa aagcaaaaaa tcctcggcat tgttttgtta gttgccggat 1396861 ttttcgaagc attctctgcc ggcatgaata acgtggcgaa tgctgttggc ccgttagtag 1396921 ctgccggtgt gcttgatgtc ggaaaaggaa ccttgtatgg aggagctttt gttgctcttg 1396981 gcgcactgtt attaggccgg cgagtgctag aaacaaacgg gaagaaaatt acgaggttct 1397041 ccaaagggga aggcattctc ttatccggta caggagcggg actggtgatc atcagttctg 1397101 tatttgggat gccggtgccc ttggcgcaag tcacgtcatc gtctattatc ggaataggca 1397161 tggcgaaaaa cggtccgaac gtgttccata aacaagttgt tcaaacgatg ctgaaggtat 1397221 ggatcgtatc gccgttttta tctttatcga tttcttatct gcttgtatcc ttgtttttaa 1397281 aagcagatta ttattcgatc tttatcatgg taagtgtgct tttagcggcg ggcggtgcca 1397341 tcagcctgac aaaggccatt cgtaaagaga gacgctcagt ccacgaacaa ggcgggggaa 1397401 tctgatcatt aatctgagta attttataag ttaactagga ggagatggat attatgagct 1397461 tagcaccaca cggaggaaca ttagtaaaca gagtagatga atcatatgat gtgagcggca 1397521 ttcaaaaaga aattgaactt gatttaattt ctttcgcgga tttggaattg atcggtatcg 1397581 gtgcatacag cccgattgaa ggtttcttta atgaaaaaga ttacgtatca gtggtcgaaa 1397641 acatgcgtct ttcttccggc gttgtctggt ctcttccaat cacgcttccg gtcgatgcgc 1397701 aaaaagcagc ggaactgtca cttggtgaaa cggtaaagtt aacgtatgaa ggagaaactt 1397761 acggcgttat ccaaatcgaa gacctgtacg tgcctgacaa acaaaaagaa gctgtcaatg 1397821 tgtacaaaac agatgaacag gagcatcctg gtgttaaaaa gctgttcagc cgcggcaata 1397881 catatgtcgg cggaccgatt acgttgatta aaaaagcttc aaaacagttc cctgaattta 1397941 catttgaacc gtcagaaacg agacgccagt ttgcggaaaa aggctgggaa accattgtcg 1398001 gtttccaaac aagaaaccct gttcacagag cgcatgaata cattcaaaaa acggctcttg 1398061 aaacagtaga cggcttgttc ttgaatccgt tagtaggtga aacaaaatct gatgacattc 1398121 cagctgatgt acggatggaa agctaccaag tgcttcttga tcattattac ccgaaagatc 1398181 gtgttttcct tggtgtcttt ttagcggcga tgcgttatgc aggcccgaga gaagcaattt 1398241 tccacgcgct tgtcagaaag aactacggct gcacacattt catcgtcggc cgtgatcatg 1398301 caggtgtagg cgactattac ggaacatacg aagcacagga actgtttgac acatttaaac 1398361 ctgaagaact cggaattaca ccgctgaaat ttgagcacag cttcttctgt aaaaaatgcg 1398421 gaaatatggg aacagcaaaa acttgccctc atggcagaga gcatcacgtc attttatcag 1398481 gcactaaggt aagaggtatg ctgagagacg gtgtgctgcc gcctgctgaa ttcagtcgaa 1398541 aagaagtagt agaagtgtta atcaaaggga tgaagaaaaa agaagaagta ggcgtatctt 1398601 aaggaggact ggcagtgaca aatcgcgata ttgtatggca tgaagcctct atcacaaaag 1398661 aagagtatca gcaaaaaaac aagcataaaa gctccattct ctggctgaca gggttaagcg 1398721 gctcaggcaa atcaaccatt gccaacgccg ctgcgagaga attgtttgag caaggctacc 1398781 aagtcattgt gctggacggg gataatatcc gtcacggcct aaatagggat cttggttttt 1398841 ctgatgaaga ccgaaaagaa aacatccgcc ggatcggaga ggtggcgaag ctttttgttc 1398901 agcagggaac cattgtgatt actgctttta tctctccttt ccgcgaggac agacaacagg 1398961 ttcgcgagct tgtggaagcg ggcgaattta atgaagtcta cattaaatgc gaccttgata 1399021 tttgtgaaca aagagatccg aaagggcttt acaaaaaagc aagaaacggc gagattccgt 1399081 tctttacagg aattgattct ccttatgaag aaccggaagc tccagagctc gttcttgatt 1399141 caggacagca tgaccgtgaa gcgtgtaaaa atcagctgat cgagtttgtt aaacaaaaat 1399201 tgagctgaat atgatctgct gcgttcttct cagatgccgg aatgcaagcg agaacatcat 1399261 cacagcgaat cttctggaag aactcgaata gatcggggga aatacgatgg ggaaagtata 1399321 tattgtagga gcgggtcccg gtgaccctga tctgctgaca attaaagcgc tgaaagccat 1399381 tgaaaaagct gatgtcatct tatatgacag attagtaaat aaagagattt tacaatatgc 1399441 caaagagcaa gcagacctga tctactgcgg gaagcttccg gattttcata cgatgaagca 1399501 ggaaaccatc aatcgatttc ttgtgaagta tgcgcaaaaa gggaaaatgg ttgtcagact 1399561 gaaaggcgga gacccttttg tgttcgggag aggaggggaa gaagcggaat gcctctctga 1399621 aaatggaatt ccgtttgaaa tcattcccgg cattacgtct ggaatcgcgg cagccgctta 1399681 tgccgggatt cctgttaccc atcgggatgc gggctctaac gtcgcttttg taacgggtca 1399741 ctataaaaaa gaagaagatt ttgaggaaaa gtggaaagcg ctggctacag gaattgatac 1399801 acttgtcatc tatatgggta tcaaaaacgt gcagcagatt gaaagaaaac tccttgaaaa 1399861 tggccgggac ggttctacgc cagcagcctt tattcattgg gggacaacgg acaagcaaaa 1399921 atctgttttt tgtacagttg acaccctttc agaaacggtg ataaaagaaa acattacaaa 1399981 tccgagttta attgtcattg gaaatgttgt aaattatcac tataagctgg aatggtttga 1400041 atctgaacta aaaaaacaag atttaagcga ggcgttgtaa aaatgaaaca agcaatttta 1400101 tatgtcggcc acggcagccg ggtcaaaaaa gcgcagcaag aagccgcagc ctttttggaa 1400161 ggatgcaagg cccacatctc tgtgccagta caagaaatca gctttttaga gcttcaggag 1400221 ccgacaattg agacaggatt tgaagcatgt gtgaagcaag gtgccactca tatcgcagtg 1400281 gtgcctctgc ttcttttaac agctgcgcat gcaaaacatg atattccgga agaaattgtc 1400341 cgtgttgcat ctcgatatcc atcagtccgt atttcatacg gaaagccgat cgggattgac 1400401 gaagaagtag tcaaggctgt atatcaccga atgaaagaca taggtgttcc gtatgaaaat 1400461 gccagagtgg tgctcatcgg aaggggaagt tcagatccag acgtcaaaag agacgtaacc 1400521 ggaattgcta atcttcttca ggaaatggtt ccagtgaagg aagtcattcc gtgctttttg 1400581 acagcatgcg gccctaatta caaagaggtt ttttcagaac ttgaaaaaga tgacggcata 1400641 acaaccttta tcgttccata tttgcttttt acgggtatgc tgatgaatga aatcgaacga 1400701 gaggttcaga aattaaaagc ccataatccg aacgtctacc tctcttccta tatcggtttt 1400761 catcctcatg tgaaaaacgc atttttgaac cgtgtgagag aaactgcggc aaattctgag 1400821 ggacaatttg attttgatgg aggttcatat gcttccgctg cacattagcc tggaaaagaa 1400881 gaaggttgtg attgcggggg gcggaagcat cgctctcaga aggctgaaaa cggtgatttc 1400941 tgagggagct gatataacgc ttgtcagtcc ggatgtggaa ccggaaatca agcaaatggc 1401001 agaagagcgg cgtatcaaat gggaaaaacg gacaattgaa aaagaagatt atctcaatgc 1401061 tttcttcatt attgctgcga cggataatgc ggcagtgaac aaagaaattg cccaatccgc 1401121 ttcgcctttt cagcttgtca attgtgtcag tgacgctgag cttggcaatg tatatatgcc 1401181 gaaaatcgta aaaagagggc atgtcactgt gtctgtttct acaagcggag ccagtccaaa 1401241 gcacacgaaa gagcttgctg aaaacgtgga taagctgatt gacggcgatt ttgttgctga 1401301 agtgaacagg ctttatcaga tgagaagaaa gaaataagcc agagcataca aatgctctgg 1401361 cttttcttta tgcggctcag ctttttttga gcttgatgac agtatcagca tcaggcgtga 1401421 caaagacggt atgctggctg tcataagtga cgaaaccggg tttcgcgccg tttggttttt 1401481 tgacatgcct gatttttgta taatctacag gcactgaact tgaatcttta gcttttgaaa 1401541 aataagctgc aattgtcgcg gcttccatga ttgtttgctc atcaggttcg ctgcttctga 1401601 tcacaacgtg ggagccggga atgtccttcg tgtgaagcca gatatcgtct ctggccgcca 1401661 ctcttgtcgt taaatattca ttttgacgat tgttcttacc cactaaaatt gtcagccctg 1401721 aggtggattc atatgtttct aacaccggat tgtgcggttt ttgctttttc tggccttttt 1401781 gctgcttagg gcgtaaatat ttgccctcaa caagctcttc cctgatttcg ctgatatccc 1401841 ggggagaagc ggacgaaagc tgctgaatca gctgatcaaa atattcgatc tcttcctgtg 1401901 ccagcctgat ttgctcctcg acaactgcga ccgaattttt cgctttctga tacttcgtga 1401961 aataggcctg tgcgttttca gaaggcgttt tgttcgggtt taaaggaatc gtgattgtcg 1402021 ggctttcttc atcataataa ttgatgacct cagcctgttt atcacctttt ttcagcatat 1402081 ataaattagc ggttaaaagc tctccgtaaa gctgaaattc cttcgcgttt tccgaatact 1402141 ccagggtttt ctctaatttt ttgattttgt tggcattctt cttccgttcg ttcacaacaa 1402201 aacgctcaag atcctgagcc tgttgcttaa cccggtctcg ttcagctttt ccgaaataaa 1402261 aacggtcgag cagttcgctt aatgaatcaa aacggcgcgc ttcgcccttt agatgagtca 1402321 gctccagcag ataaaaatat tcctttccgt ttacagtcgt aatgttggga atgaaacggt 1402381 gctctttcac ttcggcaaac agtgccagca acgcttttgg cagtgtgact ttgttggcaa 1402441 ggcctgctct gtgaaccgct tctttggcga aaagcggaga cacgcctgaa aagtggtcga 1402501 caatttgttt atcaagcctt ccttcttgaa agctgaggtg acgcaaaata tcatcttctg 1402561 acgcctcaag aggcgatatt ttgtcctgag caggcggaag cttataatct tggccgggca 1402621 gtactgtacg gtagctgttc attgacggtg ataaatgctt aagtccgtcg ataatcacat 1402681 tttctgctgc gtcagtcaaa atgatattgc tgtggcggcc cataatttct acataaagct 1402741 ttcgtacggt ttcatcgcca atttcgtttc ggcttttgat atgaaaaatc ataatgcggt 1402801 ctaagcccgc ttgttcaatt ttctcaatga atccgccttc gatatgcttt ctcagcaaca 1402861 tgcaaaacat tggcggttcg cttggatttt cataagcttg tgccgtgata tgcacccgtg 1402921 aatagctcgg atgtgccgat aataatagtt tttggttttt tcccttggca cggatgtgga 1402981 aaatcacatc gtgcttatat ggctgatgga tttttgtaat tcgtccgccc attattttct 1403041 cgttaagttc gtgtgtcatt ccgtatgtaa acatgccatc aaacgacata tgcaatacac 1403101 cctctcattc ttcctgcatt cgataattat agcatgaaat gggacgagtc agaataagca 1403161 tgcttataga gtgatatctc tataagagag caggggagtg gacgagcgga atgaagtttc 1403221 atgaaatggg acaaacagat ttactagagg caaccaatac gtccatgaaa caaggattaa 1403281 cagaaaaaga ggtaaaaaaa cgccttgaca agcatggacc aaacgagctg caagaaggga 1403341 aaaaaacttc agcgcttctc ttgtttttcg cgcagttcaa agattttatg gtgcttgtgc 1403401 ttctggcggc aacgttaatc tcaggatttc ttggtgaata tgtagatgcg gttgcgatta 1403461 ttgcgattgt gtttgtgaat ggcatactcg gtttctttca agaaaggcgt gctgagcaat 1403521 ctcttcaggc tttaaaagag ctttcaacac cgcacgtcat ggcactcagg gaaggaagct 1403581 ggacaaagat tccttctaag gaactggtgc cgggtgatat tgtgaaattt acgagcgggg 1403641 acagaattgg cgcagacgtt cgaattgttg aagcgagaag ccttgaaata gaagaatcag 1403701 cgctaaccgg ggaatcaatc ccggttgtga agcatgctga taaattgaaa aaaccggatg 1403761 tttcactcgg cgatattacc aatatggcat ttatgggtac gattgtgacc cgcggcagcg 1403821 gtgtcggggt tgtcgtcggg acaggaatga atacggctat ggggaaaatt gccgacatgc 1403881 ttgaatcggc agggacattg tcaaccccgc tgcaaagaag actggagcag ctcgggaaga 1403941 ttttgattgt tgttgcattg cttctgaccg tacttgtcgt tgctgtcggt gttattcagg 1404001 gtcatgatct gtacagtatg tttttagcag gtgtctcgtt agcggtagcc gctattccgg 1404061 aggggctgcc ggcgattgtg acagtggcgc tttcgcttgg tgtacagagg atgattaaac 1404121 aaaaatccat tgttagaaag cttcctgctg ttgaaacgct tgggtgtgcg tctatcattt 1404181 gctcagataa aacagggaca atgacccaaa acaaaatgac agtgacgcat gtctggtccg 1404241 gagggaaaac atggagagtg gcaggggccg gctatgaacc gaaaggaagc ttcacactaa 1404301 acgaaaaaga gatcagtgtc aatgaacata agccgcttca gcagatgctt ctgttcggag 1404361 cgctttgtaa caactccaat attgagaaaa gagacggcga atatgtgctt gacggagatc 1404421 cgacagaggg agcgctgctc accgcggcaa gaaaaggcgg tttttcaaag gagtttgttg 1404481 aatctaatta cagagtgatt gaagaatttc cgtttgattc cgcacggaaa atgatgactg 1404541 tcatcgtaga gaatcaagac agaaagcgct atatcattac aaaaggtgcg ccggatgtac 1404601 tcatgcagcg atcttcccgt atttattatg atggctcagc ggctcttttt tcaaatgaaa 1404661 gaaaagcaga aacagaggcg gtattaagac atttggcatc acaggcgctc agaacgatag 1404721 cggtcgccta caggccgata aaagcaggcg aaacaccgtc aatggagcag gcggaaaaag 1404781 atctgaccat gcttggcctt tcaggtatca ttgatccccc gcggccggaa gtcagacagg 1404841 cgattaaaga atgccgtgaa gcgggaatta agaccgtcat gattacaggt gatcatgtag 1404901 aaaccgctaa agcgatagcg aaagacttgc gcctccttcc gaaaagcggc aaaatcatgg 1404961 acggcaagat gctgaatgaa ctttctcaag aagagctttc tcatgtggtg gaggatgtgt 1405021 atgtatttgc ccgcgtttcc cctgaacata aactaaaaat cgtaaaagcc tatcaggaga 1405081 acgggcatat tgtggcgatg acgggagacg gcgtcaatga tgctcctgcc attaaacagg 1405141 ctgatatcgg cgtctctatg ggcattaccg ggacagatgt ggccaaagaa gcatcatctc 1405201 ttgttctcgt ggatgataat tttgcgacga ttaaatcagc gataaaagaa ggcaggaaca 1405261 tctacgaaaa tatcaggaag tttatcagat acctgttggc gtctaacgtc ggagaaatcc 1405321 ttgtcatgct gtttgcgatg ctgcttgccc ttcctttacc gctggttccg attcagattt 1405381 tgtgggtcaa cttggtgacg gacggattgc cggcaatggc gctcggcatg gatcagccgg 1405441 aaggagacgt catgaagcgc aagccccgtc atccgaaaga aggggtattt gcccgcaagc 1405501 taggatggaa ggtcgtttcc agaggatttt taatcggagt tgccactatt ttagcgttta 1405561 tcattgtgta ccaccgcaat ccggaaaact tggcttatgc ccagacgatc gcgtttgcca 1405621 cattggtgct cgctcagctt attcacgtgt ttgactgccg cagcgaaact tctgttttct 1405681 ctagaaatcc gtttcaaaac ctgtatttaa tcggcgcggt attgtcatcc attttgctga 1405741 tgcttgtagt aatctactat ccgccgcttc agccgatttt ccatactgta gccatcacgc 1405801 cgggggactg gatgctcgtc atcggtatgt ccgccatccc tacttttttg ctggcggggt 1405861 cacttttaac aagaaaaaaa taaattcata tgatataatc ttaggggtaa tagcgtgtct 1405921 attgcccttt tattatgaga acagggaaga attgggtgtt ttaaaatgat acgaagtatg 1405981 acaggcttcg gcagtgcaag caaaacacaa gacgatctct ctgtaagcgt tgaacttaaa 1406041 tctgtgaact acagatttaa agaagtgaac gctcgtttgc caaggccttt gctatatttt 1406101 gaagataagc tgaaacagac cattctgcag catattcagc gcggaagaat tgagcttttc 1406161 gtatccgttg acagcgatat gcttgttgag aaaaggcttg aaattgattg gccgctgctc 1406221 gatgagtttg tcgcagccgc gagagatatg aagaagcggt atcaattgtc tgcagagccc 1406281 gatgtaatgg atttctttaa gcttgatcat gtcgtccagg ttcatgaaga acagacgcaa 1406341 aatgacaagc tggaggcgtt gatcatcgat gctgcagaag aagcggtaaa aggtctctgt 1406401 gaaatgcgtg aaaaagaggg gctgctctta gcgaaagact gcctgatgca tattgatcag 1406461 cttgaagagc tggtgagaga aactgaattg ctggctgcag atgtcgtatc tcgttaccgg 1406521 gaacggctgt atgccagaat caaagaatgg actgaagacg tattagacga gagccggctt 1406581 gtaacagaat gcgctatttt tgcagaccgc tctgatatca ctgaagagat tacaaggctg 1406641 aagagccact tcgcccagtt tcgtgatata ttagctagtg gcggagctgt cgggcgcaaa 1406701 ctcgactttc ttgttcagga gctcaatcgg gaagcaaata cgatcggctc aaaagcaaat 1406761 gatcatcaga tcacaaagct tgtcgttgaa atgaaaagtt ctattgaaaa aataaaagaa 1406821 caagtgcaaa atatagaata gtgactgtgc gtattgttta cagacggtct tactaggcta 1406881 aactagagac gtctatttta cagggggaac gtagaagatg acgattaaac tgattaatat 1406941 cggatttggc aatatcatct ccgccaatcg gatgatttcg attgtcagcc cggagtctgc 1407001 gccaatcaaa cggatgattc aggatgcaag agaccgcgga atgctaattg acgctacata 1407061 cggacgaaga acccgtgcag ttgtcgtcat ggatagtgat cacattatct tatctgccgt 1407121 ccagcctgag acagttgcac acagactttc tgttaaagaa gaaattatgg atgaagggca 1407181 ggggtaattg ccgcatgaaa gaaagagggt tattaatcgt tctctcaggt ccctcaggag 1407241 ttggtaaagg aacggttcga caagcgatct tttcgcagga agacacaaaa tttgaatatt 1407301 cgatttcagt aaccacaaga agtccaagag agggcgaagt gaacggagtc gattattttt 1407361 tcaaaacaag agacgaattc gagcaaatga ttgcggacaa caagctgctt gaatgggcag 1407421 agtatgtcgg caattattac ggcacgccag tcgattatgt tgaacagacg cttcaagatg 1407481 gaaaagacgt ctttttagaa attgaagttc aaggggctct tcaagtgaga aatgctttcc 1407541 cggaaggcct gtttattttc cttgcgcctc caagcctttc tgaactgaaa aacagaatcg 1407601 tgacacgagg aacagaaaca gacgctctga ttgaaaatcg aatgaaagcc gcaaaagctg 1407661 agatcgaaat gatggatgct tatgactatg tcgttgaaaa cgataatgtc gaaacggctt 1407721 gcgataaaat caaagcaatc gttcttgctg aacatttgaa gcgtgaacgc gttgcaccaa 1407781 gatataagaa aatgctggag gttgaataat caatgttaga tccgtcaatt gattctttaa 1407841 tgaataaatt agattcaaaa tatacgctgg tgactgtttc tgcgagacgt gcccgtgaaa 1407901 tgcaaatcaa aaaagaccaa atgattgaac atacgatttc acacaaatat gtaggcaaag 1407961 ctttagaaga aattgatgca ggcctgcttt cgtttgaaaa ggaagaccgc gaatagtagc 1408021 acaagtagca acctatatca tgtaggttgt tatttttttc cgtgcggttt tgtaaagtgc 1408081 agagggggag aattcattgc ttaacaatcg aaatgtgtta ctttgcgtga gtggaggcat 1408141 cgctgtttat aaagcctgtg cgttaacgag caagctggtt caggcaggag caaatgtcaa 1408201 agtgattatg actgaatccg cttgccgatt cgtttcaccg ctgacatttc aggcattgag 1408261 ccgccacgaa gtctatacag atacatttaa agaacaaaat ccaagcgtca tttctcatat 1408321 tgatgccgca gactgggccg acttgattat cgtagcgccg gctacggcta atgtgattgg 1408381 aaaactggca aacggcatcg ctgatgatat gctgacgaca acattgttgg cagcaacggc 1408441 tcccgtttgg atcgcgccgg caatgaacgt tcatatgtat gaccacccgg cagtcaaacg 1408501 aaacatttct gttctttatc aggacggtta ttgttttatt gagccaagtg agggctattt 1408561 agcatgcggt tacgtaggaa aaggcagatt ggaagagccg gaaaacatcg taaagctggc 1408621 cgaaaaacat tttgctgaag aaacatccgc tcctttagaa ggcaagcatg tggtcattac 1408681 agccggccca acgcgggaag cgattgatcc tgtccggttt tttaccaata aatcgacggg 1408741 caaaatgggc tacgcactgg cggaggctgc tgttcagctc ggcgcacggg taatcttaat 1408801 ttctgggcct gtttcacttg atcagcctaa aggccttgct gagtttatcc ctgttcaatc 1408861 ggctgcggat atgcgcgaag ctgtgctctc tgtgtatgac gcaagcgata tagtcattaa 1408921 aacagctgcg gtagccgatt ttacgccgaa aacagtattt gaccataaaa tgaaaaaaca 1408981 agacggcggc atgaccttag aactgaaaag aacagtcgat attttgaaag aattgggcga 1409041 gaaaaagaaa gagcagattt tggtcggatt tgccgccgaa acacaagaca ttgaacacta 1409101 tgcacgtaaa aagctcgccg ctaaaaacct tgatttgatt gtggcaaatg atgtgaaagc 1409161 aaatggggcc ggttttggtg ctgatacgaa tatcgtgaca atctttttca aagacgggca 1409221 taaacgcgaa ctcccgatta tgtctaagct cgatgtttct tttgaaatcc ttcaggagat 1409281 cgcagccctc tcaaaacaaa ccggagagcg ctcatgaatt ttgcagaagt catcgttgat 1409341 gtcagcacca aaaatataga caggcctttt gattataaaa tcccagacca tctgaagggc 1409401 atgatcaaaa cggggatgcg ggtcattgtt ccgtttggcc cccgtaagat tcaagggttt 1409461 gtgacagcag tcaaagaagc atctgaccta tcgggaaaat ctgtcaagga agtagaggat 1409521 ttattagatc ttacacctgt tctgacagag gagcttatga ttctgtcatc atggctgtca 1409581 gacaaaacgc tgtcttttaa aataacggcg cttcaagcaa tgctgcctgc cgccttaaag 1409641 gcgaaatatg aaaaagaatt aaaaattgca cacggagccg atcttccgcc gcaagtggaa 1409701 cggctgtttt ctgaaacaaa gacgctgctg tattcagata tacccgatca tgagacgctg 1409761 aaactgattc aaaggcatgt tcaaaaaggg gacattgacg tgacgtataa agtcgcgcaa 1409821 aaaaccaata aaaaaatggt caggcatatt caggcaaatg cgagtaaaga agagcttgct 1409881 aagcaggctg agggattgtc ccgccaagca gcaaaacagc aggcgattct tcactttctc 1409941 atctctgagc cggaaggtgt gaaaattcct gcggcggaat tgtgcaaaaa aacggacacg 1410001 agctctgcaa ccatcaaaac ccttatccaa aaagggcttt tgaaggaaag ctatgaagag 1410061 gtttacagag atccctatca ggacaaaatg ttcaaaaaaa cagagcccct gccgctgaca 1410121 gacgaacaga gggctgcctt cgagcccata cgcgagacat tggacagcga tgagcataaa 1410181 gtgttcctcc ttcacggcgt gacaggaagc ggaaaaaccg aaatttatct gcaatcaatt 1410241 gaaaaagtac tggcgaaagg aaaagaagcc atcgtcctcg taccggaaat atcgctgacg 1410301 ccgcaaatgg tcaaccgctt caagggccgc ttcggctccc aggtggcagt catgcacagc 1410361 ggtttatcca caggagaaaa atatgacgag tggcgtaaaa tccaccggaa ggaagtacgg 1410421 cttgtcgtcg gtgccagatc cgccattttt gctccgtttg aaaatctcgg aatgataatc 1410481 atcgatgaag agcacgagtc ttcctataaa caggaagaaa tgccgcgcta tcatgcgaaa 1410541 gaggtggcaa tcaagcgggc tgagcatcac agctgcccgg ttgtattagg gagtgctacg 1410601 ccgacattag aatcatatgc tagagcgcaa aagggcgtat acgagcttct ttcactgaag 1410661 caccgtgtta accatcgggt gatgcccgag gtttcgcttg tcgatatgag agaggagctt 1410721 agaaacggca atcgctcgat gttttcagtt gaattgatgg aaaagcttga agaaacgatt 1410781 gccaagggtg agcaggcggt gctgttttta aataagaggg gctactcttc ctttgtgatg 1410841 tgcagggatt gcggctatgt cccgcaatgc ccgcactgcg acatttccat gacgtatcat 1410901 cgttacggcc aaaggctgaa atgccattat tgcggacatg aagagcctgt tccgcacact 1410961 tgtcctgaat gcgcaagcga gcatatccgc tttttcggaa cgggaacaca gcgagtggag 1411021 gaagagctga caaaagtgct gccaagtgcg agagtgattc ggatggatgt tgacacgaca 1411081 tcacggaaag gcgcccatga aaaattactg tcagctttcg gagaaggaaa agcggatatt 1411141 cttctcggaa cgcaaatgat cgcgaaaggg cttgattttc cgaatgtcac gcttgtcgga 1411201 gtgttaagtg ctgatacaac acttcatatt cctgatttca gatcggctga aaaaacattt 1411261 cagctgttaa cgcaagtcag cggccgggca ggcaggcatg aaaagcccgg ccatgtcatc 1411321 attcaaacgt atacaccgtc tcattacagt atccagctga cgaaaacaca cgattatgaa 1411381 acgttctatc agcatgaaat ggcgcacagg agagagcaat cctatccgcc atactactat 1411441 ttggctcttg tgactgtttc tcatgaggaa gtggcgaaag cagcggttac agctgaaaaa 1411501 atcgctcatt ttttgaaagc aaactgcgga gctgacacga aaattctcgg accaagcgcg 1411561 tcgccgatag ccaggatcaa agatagatat cgctatcaat gcgtgataaa atacaaacag 1411621 gaaacccagt tatccgcttt attgaagaag atactggaac attataaacg cgaaattgaa 1411681 caaaaacatg taatgatttc aattgatatg aatccttata tgatgatgta agatctcacg 1411741 tcttggaggg taacaaattg gcagtaaaaa aggtcgtcac acatcctgcg gaggttttgg 1411801 aaacacctgc ggaaaccgtg actgtttttg ataaaaagct aaaaaaactg cttgatgata 1411861 tgtacgacac catgcttgaa atggatggtg tcggactggc agcgccgcaa atcggcattt 1411921 taaaaagagc ggccgtcgta gaaatcgggg atgacagagg gagaattgat ctcgttaatc 1411981 ctgaaatttt agaaaaaagc ggcgagcaaa ccggaattga aggatgcttg agctttccta 1412041 acgtctatgg tgatgtcaca cgtgccgatt atgtcaaagt gcgtgcgttt aaccgtcagg 1412101 gaaaaccgtt cattctggaa gcgcgaggct ttttagcaag agccgtgcag catgaaatgg 1412161 accacttaga cggtgtgctg tttacatcta aaataagtaa atactataca gaagatgaac 1412221 tagcggatat ggaaggatga tttgatgacg agaatcgtat ttatgggaac gccggatttt 1412281 tcagttcctg ttttaagaac cctgatagag gacggatatg aagtagtggg ggtcgtcaca 1412341 cagccggacc gtccgaaggg cagaaaaaaa gtactgacac ctcctccggt aaaggaagag 1412401 gcattgcgcc acggcatccc ggttcttcag ccggaaaaag tcagattgac agaagaaatt 1412461 gaaaaagtgc tggcattaaa gcctgacctg attgtaacgg cggcattcgg acaaattttg 1412521 cctaaagagc ttctcgacag tccaaaatac ggctgcatta acgttcacgc atcccttttg 1412581 ccggaactgc gcggcggtgc tccgatccat tattccattc tgcagggaaa gaagaaaacc 1412641 gggattacca ttatgtatat ggtagaaaaa ttggatgcgg gcgatatgat ctcaaaagtg 1412701 gaagtggaca ttgaagaaac cgacaatgtc ggaacactgc acgataaatt aagcgttgct 1412761 ggcgcgaagc tattgtctga aacggttcca aacgttattg ccggcagcat atcacctgaa 1412821 aagcaggatg aagagaaagc gacgtacgcg cctaacatta aaagagagca agagctgctc 1412881 gactggtcca gaacgggcga agagctttac aaccagatcc gcggcttaaa tccatggcct 1412941 gttgcttata cgactctaaa cggacaaaac ttgaaaatat gggcgtcgaa aaaaatagcg 1413001 gcaccaacaa cagctgagcc cggcacagtc gttgcagttg aaaaggaagg aattatcgtt 1413061 gccacaggta acgagacggc tctgttatta accgaactcc agccggcagg caaaaaacga 1413121 atgaaaggcg aagactttgt gcgaggcgct catgttgaag ccggtgatgt gttaggagta 1413181 aacaatgaaa aaaactagtg ttcgtgacat cgcccttgag gcgctgatca aattagaaca 1413241 aaaccaggca tacagcaacc tgctgctgaa atcggtcatt aaatcaaatg aactgagtga 1413301 tcagaacaga gggcttttga ctgaacttgt ctatggtaca ttacaaaata agatcgcgct 1413361 tgattatatg cttaaaccgt ttatcaataa gcctcaaaag gtaaagccgt gggtgattca 1413421 gcttcttcgc ctatccttat atcaaatgga gtatttggag aagattccag acagggcagc 1413481 cattcatgaa gcggttgaga ttgctaaaat ccgcggacac aaaggcattg cttcatttgt 1413541 caacggcgtg ctccgttcta ttcagcgcga aggtgttcca tcctttgacg cgatcgaaga 1413601 tcctgtccgc cggctggcga cagaaacaag ccatccggaa tggcttgtga aagagtgggc 1413661 ggatgcgtat ggatttgaag ctgcggaaaa gatttgccgc atccatctca ttccgccgaa 1413721 acagacgctg cgtgtcaatc aaatgaaagc agacagagct gagctgcttg accaaatggc 1413781 tgctgaggga atcgaagttg aaaaaggcga cctcgctgaa gatgctgtga agctcttaaa 1413841 gggaacaatt gccggaactc atttcttcca aaacggcgaa gtttctatcc aggatgagag 1413901 ctccatgctc gtcgcccgcg cccttgatcc taagtcagat gaaacagtgc ttgacgcgtg 1413961 tgcggcgcct ggcggaaagt cggctcatat cgcagaatta atgaagaaca aggggagcgt 1414021 tacgtcgctt gatcttcaca aacataaagt gaagctgatc aaagaagcgg cagatcggct 1414081 tggcctgaca atcattcatg cggaaacaat ggatgctaga aaagcggggg aaacgtttga 1414141 aaacgaacag tttgaccgaa tattggtcga tgccccgtgc tcaggtttcg gtgttatcag 1414201 aagaaagccg gacatgaaat acacgaaaaa acctgacgac agcgcccgtc tagctgaaat 1414261 ccagctgtcg atcttgaggg aaatcgcacc attagtaaaa aaaggtggca ctcttgtcta 1414321 cagtacgtgt acaatggacc ggacagaaaa tgatgaagta atacatgcgt ttatacaaga 1414381 acatcctgat tttgaacccg atttgtctct tgaaaagcgg ctgcctgaaa aggtgagacc 1414441 ctttgttcgg gatggaaggc ttcaaatcct tcctcattat ttcggaacag atggtttctt 1414501 tatttgcagc atgagaaaga agggataagc aatggcagaa cttaataaaa caaaagtaag 1414561 aaaagaattg cggacagagc gtccgtctat ttattctttt gaattagatg aaatcaaaca 1414621 atggctgaca gacaatggag agaaaccgtt ccgtgcagcc cagatctttg aatggctata 1414681 tgaaaaacgc gtatcttctt ttgaagatat gacaaacctc tcaaaggatc tgcgtgagaa 1414741 attaaacact cgctttgtgt taacaacgct gaaaacggct gttaaacaaa cctctcaaga 1414801 cggtacgatg aagtttttgt ttgagcttca tgacggttat accatcgaaa ccgttttaat 1414861 gagacacgag tatggcaatt ctgtatgtgt aacgacacaa gtcggctgcc gtattggctg 1414921 cacattctgc gcgtcaacgc ttggaggctt aaaacgaaac cttgaagcag gggaaattgt 1414981 cgctcaagta gtcaaagtgc aaaaagctct tgatgaaacg gatgaacgcg tcagctctgt 1415041 cgtgatcatg ggaatcggcg aaccttttga taactttaac gaaatgctcg ctttcttgaa 1415101 aatcattaac catgacaagg gcctgaatat cggtgctcgc catattacgg tctctacgag 1415161 tggaatcatc ccgaaaattt acgaatttgc tgatcagcaa atgcagatta actttgcaat 1415221 ttctctgcac gcgccgaaca cagaaatcag aagccgtttg atgccgatta acagagcata 1415281 taaactgcct gatctaatgg aagccgttaa atattatatt aataaaacag gacgccgtat 1415341 cagctttgaa tacgggctgt tcggaggcgt aaacgaccag gtggaacacg ccgaagagct 1415401 tgccgacttg ctggaaggag tcaaatgcca cgtgaacttg attccggtaa actacgtgcc 1415461 tgaacgggac tatgtgcgca caccgcgtga tcagattttt gcttttgaaa aaacgctgaa 1415521 atcccgcgga gtaaatgtca caatccgaag agagcaagga catgacattg acgcagcctg 1415581 cggtcagctt cgcgcgaagg agcgtcaaga cgagacgagg tgatgagggt tgttaacagc 1415641 cttaaaaaca gatacaggaa aaatccgcca gcataatgaa gatgatgcgg ggatattcaa 1415701 ggggaaagat gaatttatat tagcggttgt cgctgatggc atgggcggcc atcttgctgg 1415761 agatgttgcg agcaagatgg ctgtgaaagc catgggggag aaatggaatg aagcagagac 1415821 gattccaact gcgccctcgg aatgtgaaaa atggctcatt gaacagattc tatcggtaaa 1415881 cagcaaaata tacgatcacg ctcaagccca cgaagaatgc caaggcatgg ggacgacgat 1415941 tgtatgtgca ctttttacgg ggaaaacggt ttctgttgcc catatcggag acagcagatg 1416001 ctatttgctt caggacgatg atttcgttca agtgacagaa gaccattcgc ttgtaaatga 1416061 actggttcgc actggagaga tttccagaga agacgctgaa catcatccgc gaaaaaatgt 1416121 gttgacgaag gcgcttggaa cagaccagtt agtcagtatt gacacccgtt cctttgatat 1416181 agaacccgga gacaaactgc ttctatgttc tgacggactg acaaataaag tggaaggcac 1416241 tgagttaaaa gacatcctgc aaagcgattc agctcctcag gaaaaagtaa acctgcttgt 1416301 ggacaaagcc aatcagaatg gcggagaaga caacattaca gcagttttgc ttgagcttgc 1416361 tttacaagtt gaagagggtg aagatcagtg ctaatcggca agcggatcag cgggcgttac 1416421 caaattctcc gcgtcatagg cggcggggga atggccaacg tgtatttagc tgaggatatc 1416481 attctagacc gtgaagtcgc aattaaaatc ctgcggtttg actatgcaaa tgacaatgaa 1416541 tttatcagac gtttccgcag agaagcccaa tccgcatcaa gcctcgatca cccgaatatt 1416601 gtcagcattt atgatttggg cgaggaagat gatatttatt atattgtcat ggaatacgtt 1416661 gaaggcatga cgcttaaaga atacataaca gcaaatgggc cgcttcaccc taaagaagcg 1416721 ctgaacatca tggagcaaat tgtctcagcc atcgctcatg cccatcaaaa ccagattgtt 1416781 cacagagaca tcaagccgca taacattttg attgatcata tgggaaatat caaagtaacg 1416841 gattttggaa ttgcgacggc actaagttcg accacaatca cccataccaa ttcagttctg 1416901 ggctcggtcc attacttatc acctgaacag gcccggggcg gcttagccac aaaaaaatcg 1416961 gatatttatg cgcttggaat cgttctattt gagcttttaa ccggccgtat tccgtttgat 1417021 ggagagtcag cagtcagcat cgccttgaag catcttcaag cggaaactcc ttcggcaaaa 1417081 aggtggaatc catcggtccc ccaaagcgtt gaaaacatca tactcaaggc aactgccaaa 1417141 gatccttttc atcgctacga aacggctgaa gacatggaag cagacataaa aacagctttt 1417201 gatgccgaca gactcaatga aaagagattt acgattcaag aagatgaaga aatgacaaaa 1417261 gcgataccta tcattaaaga tgaagaactt gctaaagctg ctggcgaaaa agaagctgaa 1417321 gtgacaaccg cacaagaaaa caaaacaaag aagaacggca aaagaaaaaa gtggccgtgg 1417381 gttttgctca cgatatgcct cgtttttatc acagctggaa ttcttgctgt cactgttttt 1417441 ccgtcgcttt tcatgcctaa ggatgtcaaa atacctgatg tctccggaat ggaatacgaa 1417501 aaagccgcag ggctcttgga aaaagaaggt ttacaggttg attccgaggt gttggaaatc 1417561 tcagatgaaa aaattgaaga gggcctgatg gtaaaaacgg atcctaaagc ggataccaca 1417621 gtcaaagaag gcgccacggt caccctttat aagagcaccg gaaaagcaaa aacggagatc 1417681 ggtgatgtga caggccaaac ggtcgaccaa gcaaaaaaag cgttgaagga ccaagggttt 1417741 aatcatgtaa cagtaaatga agtgaatgac gagaaaaatg cgggcactgt cattgaccaa 1417801 aatccttcag cagggactga gctggtcccg agtgaagatc aagtcaaact tacagtcagt 1417861 atcggacccg aagacattac gcttagagac ttgaaaacct acagtaaaga agcagcgtct 1417921 ggatatctgg aagacaacgg attgaagctt gtagaaaaag aagcatactc agatgatgtt 1417981 ccagaaggac aggttgtcaa acaaaaacca gcagcaggta cggcagtaaa gccgggaaac 1418041 gaagttgaag tgacattctc tctcggacca gagaaaaaac ctgcgaaaac agtgaaagaa 1418101 aaggtcaaga tcccctacga accagaaaat gaaggggacg agcttcaagt gcaaatcgcg 1418161 gttgacgatg cggatcacag catctctgac acttacgaag aatttaagat aaaagagccg 1418221 actgaacgaa cgatcgaact aaagattgaa ccaggccaaa aagggtacta tcaagtaatg 1418281 gtaaacaata aagttgtcag ctacaaaacc attgagtatc cgaaagatga ataacaagga 1418341 gggaaaatat gcctgagggc aaaattatta aggcgctaag cggcttttac tatgtactgg 1418401 atgaatcaga ggattcagat aaagtaatac aatgcagagg aagaggcatt ttcagaaaaa 1418461 acaaaattac ccctcttgtc ggtgattacg ttgtgtatca agctgaaaat gacaaagaag 1418521 gatatctaat ggaaattaaa gaaagaacca acgagcttat caggccgcca atttgcaacg 1418581 ttgatcaagc ggtccttgtt ttctcagcgg ttcagccttc tttcagcacg gcattgctcg 1418641 accgcttcct ggttctcgtt gaggccaatg atattcagcc gattatatgc attactaaaa 1418701 tggatctgat tgaagatcaa gatacagaag atacgataca agcctatgca gaagactatc 1418761 ggaatattgg ttatgacgta taccttacct cctctaagga ccaagatagt ttagcggaca 1418821 tcatcccgca ttttcaggat aaaacaacgg tatttgccgg tcagtccggt gttgggaaat 1418881 cctcgcttct caacgcgatc agtccggagc tcggattaag aacaaacgag atttccgagc 1418941 atttgggccg cgggaaacac acaacccgcc acgtggagct gattcacacg tccggaggtt 1419001 tggttgcaga tacaccggga ttcagctcgc ttgaatttac agacattgag gaagaagagc 1419061 tgggctatac cttccctgat atcagagaaa aaagctcttc atgcaaattt agaggctgtt 1419121 tacatctgaa agagccgaaa tgtgcggtga aacaagctgt tgaagacggg gaattaaagc 1419181 agtatcgcta tgaccattat gttgaattta tgacggagat taaagacaga aagccgaggt 1419241 attagcataa tgataaaggt tgcaccatct attctttccg ctgattttgc cgctttaggc 1419301 aatgagatta aagatgtaga aaaaggcgga gccgattgta ttcatattga tgttatggac 1419361 ggccattttg tcccgaatat cacaatcggt ccgctgattg tagaagcggt ccggccggta 1419421 acggatctgc cgcttgatgt ccatttaatg atagaagagc cggatcgtta tatcccggct 1419481 tttgcgaaag caggcgcaga tatcctgtct gtgcatgctg aggcatgtcc gcacctgcac 1419541 cgtaccatcc agctcattaa agagcaagga gtgaaggccg gagtagttct aaacccgcat 1419601 acccctgtac aagtcatcga acatgttttc gacgatcttg atcttgttct tttaatgacg 1419661 gtgaacccgg gcttcggcgg gcagaaattt attcattcag tccttcctaa aataaaagag 1419721 gttaagcgaa tggcggatga aaaaggaaaa aaagatctgt taattgaagt agacggcggc 1419781 gtcaacaaag aaaccgctcc gctcgtcatt gaagcgggcg caaatttact cgttgccggt 1419841 tcagctgttt atggccagtc tgaccgcaaa aaagcaattt ctgaaatcag aggaagtaaa 1419901 taagcagctt tagaaaagag ctgggcatac aatagcctaa gctctttttc ctgtatgcag 1419961 agaaaggaat cagagatgaa aacaattaat atcgttgcgg gaggcccgaa aaatctcatt 1420021 cccgatctaa ccggctatac ggatgaacac acgctttgga tcggtgttga caaaggcacc 1420081 gtcactctct tagatgccgg gatcattcct gttgaagcct tcggagattt tgacagcata 1420141 acggagcaag aacgccggcg aatagaaaaa gccgctcccg cccttcatgt gtatcaagca 1420201 gaaaaagatc aaacagattt agacctcgcc cttgattggg cgctggaaaa gcagccggat 1420261 attattcaga ttttcggcat tacaggcggc agagctgatc attttttagg aaacattcag 1420321 cttctgtata aaggtgtaaa aacgaacata aaaattaggc tgatagacaa acaaaatcat 1420381 attcaaatgt tccctcctgg tgaatatgat attgagaagg atgaaaataa gcgatatatc 1420441 tccttcatac cgttttccga agacatacat gagctgaccc tgaccggttt taaatatcct 1420501 ctaaataatt gtcatattac gctcggttca acactatgta ttagtaacga actcattcat 1420561 tcacgaggta ctttttcgtt tgcaaaaggc atattaataa tgataagaag cacggattaa 1420621 gcatgtgctt tcattcaatt gctgaaaaca atgaacaagg cggttacggg acgttatagg 1420681 aggggacaaa aatgaaattt tacaccatta aattgccgaa gtttttagga ggaattgtcc 1420741 gggcgatgct gggctcattt agaaaagatt aatgcccagg ggttcaaagc cctctttcac 1420801 cacataaaaa cgcctgccac atatcggggc aggcgttcat tttgttatac acgctcaact 1420861 ttaccggatt tcaaagctcg agcagataca tatacttttt taggttttcc gttcacaagg 1420921 atacgaacct tttgaagatt cgcgccccaa gtgcgcttag aagcgttcat tgcgtgagaa 1420981 cggttattcc cagctgttgt ttttttacct gtgataacgc atttacgtgc catttgtttc 1421041 cctcctcact tgcacaaaac atctactttt taacattcat ataatcttag atgctttcga 1421101 tatggatact ttaaataatt taccacagct aaaaaacgtt tgcaactatt gtttcatcat 1421161 ctttcaagaa aattcacttg acatcttgcg gaaacagcag cgctatagta tatgtagagg 1421221 tacggccagc gattattgcc tggtcttttc ataatggaaa ccatatagta gaatagctgt 1421281 aactctatgc attcgaagga ggaactagtg tgtccattga attaagaacg aagtacggac 1421341 agattgatat atctaatgaa gtcatcgcga tggttgcagg aggcgcggcg gttgactgtt 1421401 acggcattgt cggcatggcc tctaaaaacc agattaaaga cggactgact gaaatccttc 1421461 ggaaagagaa tttcagcagg ggtgtccaag ttcgccaaga aggagaacag atacatatcg 1421521 acatgtatat cattgtcagc tacggcacga aaatttctga agtggcacat aatgtccaaa 1421581 caaaagtaaa gtacacagta aatcaaacca tcggactggc agtggattct gtcaatattt 1421641 atgtccaagg cgtacgagtg acgaacccgt agttaggagg agtaggattg tctatcagaa 1421701 cattagacgg cagaaccttt gccgagatga ttcttgcggg agcgcagaat ctgtctcaaa 1421761 acgccagtgc agttgatgca ctgaacgtgt tcccggtgcc ggacggtgat acgggaacaa 1421821 atatgaacct gtcgatgact tccggagcaa gagaagttga acaaatggat acggatgata 1421881 tcgggaaggt gggctccgcg ttatctaaag ggctgctcat gggagcacgc ggaaattcag 1421941 gagttatcct atcccaattg ttccgcggat ttagcaaaaa cattgaaacg aaaaaagaaa 1422001 ttaatgcact tgagtttgcc gctgcgctgc aagcaggtgt agacatggcg tataaagctg 1422061 tcatgaaacc tgtagagggc accattttaa cagttgcaaa agacgctgca aaaaaagcaa 1422121 tgatcttagc agaaaaagaa accgatatca ctgcgctgat gactgcagtg acagaagaag 1422181 cagaggcgtc tttaaaccgc acccctgaat tgctacctgt cctaaaggaa gtaggagttg 1422241 tcgatagcgg gggcaaaggc ctgctctgtg tgtatgaagg tttccttgct tcattaaaag 1422301 gtgaaactgt acctcagaaa gcagttcttc cgtcacttga cgacatggtc agcgcagagc 1422361 atcacaagag cgcgcaaagc atgatgaata ccgaagatat tgaatttgga ttctgtaccg 1422421 aagtgatggt taggcttgat cagacaaaaa gagagttcga cgaaggcacg ttcaggcaag 1422481 acctcagcca gttcggagat tctctgcttg tgattgcgga tgaatcgctg gcgaaggttc 1422541 atattcatgc tgaagagccg ggaaacgtgt taaactacgc ccagcattac ggtgaattga 1422601 tcaaaataaa aatagaaaat atgagagaac agcatacctc tatcatcagt caagaaagca 1422661 aacctgcaga caacgaaaca ccgccggcaa aacagccgta tggcattgtg actgtagcga 1422721 tgggagaagg aattgcagac ctatttaaaa gcattggcgc ttctgttgtg attgaaggcg 1422781 gccagaccat gaacccaagc actgaggata ttgttgatgc cgtgaagtct gtaaatgcag 1422841 atacggtatt tatcctgcct aacaactcca acattatcat ggctgctaac caagcggcca 1422901 gcgtagtgga tgaacaggtt tttgtcattc ctgctaaaac ggttccgcaa gggatgtcag 1422961 ctctgctggc ttttaacccg gatcaagaag ctgaagcgaa cgaggccaat atgctaagcg 1423021 ccattcagca agtaaaaagc ggacaggtga cgttctcagt cagagatact catattgacg 1423081 gtaaagacat taaaaaaggc gactttatgg gcattctgaa tggaacgatt atcggcactt 1423141 ctgaaaatca gctgtcagcc gcgaaaatgc tgctgtcaga aatgatcgga gaagatgatg 1423201 aaatcgtgac cattctatat ggtgaggatg cgtctcagga agaagctgag cagcttgaag 1423261 cgtttctcag tgaaaagtac gaggagattg aggttgagat ccacaatggg aaacagcctc 1423321 tgtattcgta tatagtttca gcagaataga agggcaattt gcccttctat tcttatgtct 1423381 gcttttaagt gcggcagcgc tgtaacgcgc ccgcttgcca ttttatatct gatcaattag 1423441 tctagaagca aagcgctaat aagctctggt tcataaggag gaatagcatg aaatacagaa 1423501 gcgtttttga tattatcggc ccggttatga tcggtccgtc cagctctcat acagcgggag 1423561 ctgctagaat cgggagagtg gccagaagtt tatttggcag agagcctgag cgcatcattg 1423621 tatcttttta cggctcgttt gcggaaacgt ataagggcca cggcacagat gtcgcgatta 1423681 tcggcggatt gcttgatttt gatacattcg atgaacggat taaaaccgct atacaaattg 1423741 cagaagctaa aggaattgat atagagtttc gggtagaaga cgcagtcccg gtccacccga 1423801 acacagcaaa aatcaccatt tctgatgaaa agggtgagct ggaactgacg ggtatttcga 1423861 ttggcggagg aaagattgaa atcacagaat tgaatggttt tgagctccgg ctgtcaggaa 1423921 atcatccggc catattagtt gttcataatg acaagtttgg cacaattgcc ggtgttgcca 1423981 atgttctggc gaaattttca atcaacgtag gacatatgga agtagcccgg aaagatatcg 1424041 gccagcttgc gctgatgaca atagaggtcg atcaaaatat tgacgaccac attctcgacg 1424101 agctgtcgaa gctgccgaat attattcaag tgacaaagat tgctgactag cgaaaagggt 1424161 caggaggagc cagttatgtt tcgtaatgta aaagaattaa ttgagattac taaagaaaaa 1424221 caaatattga tctctgatgt gatgatagct caagagatgg aagtaacaga aaaaacaaaa 1424281 gaggacattt ttcagcagat ggatcataac ctgtctgtta tggaagcggc ggttcagaaa 1424341 ggactcgagg gagttacgag ccaaacgggc ttaacaggcg gagatgccgt taaattgcag 1424401 gcctatattc gatcaggaaa aagcctgtct ggcccgctga ttttagatgc tgtatcgaaa 1424461 gccgttgcaa caaatgaagt aaatgcagcc atgggaacca tctgtgcgac accgactgca 1424521 ggttctgccg gtgtggtgcc cggtacgtta tttgctgtaa aagaaaagct gaatccaaca 1424581 agagaacaaa tgatccgctt tttgtttaca gccggggctt tcggatttgt cgtggccaat 1424641 aacgcaagca tttccggcgc cgccggagga tgtcaggcag aggttggatc agcttcaggc 1424701 atggcggctg cggctattgt tgaaatggca ggaggaacac ccgaacaaag cgcggaagcc 1424761 atggccatta cattaaaaaa tatgctaggc ctcgtgtgcg accctgttgc agggcttgtt 1424821 gaggtgcctt gcgtgaaacg gaatgcgatg ggcgcgtcaa atgcgatgat tgctgctgat 1424881 atggcattgg cgggcattac aagccgtatt ccatgtgatg aggttatcga tgccatgtat 1424941 aaaataggcc aaacgatgcc aactgcactt agagaaacag gccagggcgg tttagcggca 1425001 acaccgacag gaagagaatt agagaaaaaa attttcggag gagcgctagg ttcacgtgaa 1425061 acaacatcag caaactagta tagctaacat taagggtatt gggccggaaa cagaaaaaac 1425121 attgaatgaa ctcggtattt atgacatttc tgatcttctg aattatttcc cttatcgcta 1425181 tgatgactac gagctgaggg atttagaaga agtaaagcat gatgaaagag tcacagtcga 1425241 agggaaggtt cattcagagc cttctcttac ctattacgga aaaaaacgaa acaggctgac 1425301 attcaggctt ctggtcggcc actatttaat cacagccgta tgttttaacc ggccttattt 1425361 gaagaagaag ctttcgctcg gctctgtggt gacggtttca ggtaaatggg acaagcaccg 1425421 ccaaaccatc tctgttcagg agttgaaaaa cgggccgcat caagaagaca aaagcattga 1425481 accagtgtat tctgtgaaag aaaatgttac cgtcaaaatg atgaggcgct ttattcagca 1425541 ggcgctgacc caatatgcag actcacttcc tgatcctctt ccggaaaagc taagaaaaag 1425601 ctataaactg cctgactatt atcaagcgtt aaaagcaatg caccagcctg aaacaaggga 1425661 agcattaaag cttgccagac ggcggtttgt ttatgaagaa tttttgttgt ttcagttgaa 1425721 aatgcaggcg ttccgaaagg cggaaagaga gcagacacaa gggatacggc agcgtttttc 1425781 aaacgaagaa ctcatgagat ttatcaaaag cctcccgttt cccctcacaa acgcccagtc 1425841 acgcgttctt cgcgaaataa cagcagacat gtcttctcca tacagaatga accgtcttct 1425901 tcaaggggac gttggatcag gaaaaacggc agtcgccgcc attgcactgt atgccgcgat 1425961 cctatccgga taccaaggag cgctcatggt gccgacagaa attctggccg agcagcatgc 1426021 tgattcgctc gtttcgctat ttgaaaaatg ggacgtcagc gttgctcttt tgacaagctc 1426081 tgttaaagga aagcggcgaa aagaactgct tgagcgtctt gcggcgggtg agattgatat 1426141 tcttgtagga acccatgctt taatccaaga cgaggtggag tttaaggcgt tgagtctcgt 1426201 tattactgat gaacagcaca gatttggagt tgagcagcgc aaaaagcttc ggaacaaagg 1426261 gcaggatccc gatgttctct ttatgacagc cactccaatc ccaagaacat tagcgatcac 1426321 agtattcggt gaaatggatg tatctgtcat tgatgagatg ccggctggac gaaagcgaat 1426381 tgaaacctat tgggtaaaac atgacatgct tgatcgtatt ttggcatttg tcgaaaaaga 1426441 attaaagcaa ggcaggcagg cttatatcat ctgtccgctg attgaagaat cagataagct 1426501 tgatgtgcaa aacgccattg acgtgtacaa tatgctttct gatatttttc ggggaaaatg 1426561 gaatgtcggc cttatgcatg gaaagctgca ttccgatgaa aaagatcagg tcatgagaga 1426621 attcagcgca aatcactgtc aaattctcgt atcaaccact gttgtggagg ttggcgtaaa 1426681 tgttccgaat gcaacaatta tggtgattta tgacgccgac cgtttcggac tatcacagct 1426741 tcaccagctg cgcggccgtg ttggacgggg tgagcatcaa tctttctgta ttctgatggc 1426801 tgatccaaaa tcagaaacag ggaaagaacg gatgaggatc atgtcggaga ccaatgacgg 1426861 tttcgagctg tctgaaaagg atctggaact gagaggtccc ggtgatttct tcgggaaaaa 1426921 acaaagcgga atgccggaat ttaaagtggc ggacatggtt catgattaca gagcgcttga 1426981 aacggcaagg caggatgctg cgaatcttgt ggcttctgac gcgttctgga aggagccgga 1427041 atacgctgtg ttaagagatg aattgctgaa gagcggagta atggacgggg aaaaattaag 1427101 ctgagtatca gaagtttttg gtgttcagcc agaaacaatc gttgcattcc aatctatgaa 1427161 attatatact actattagta cctagtctta attgtccgga tggtgtttag atatgagaag 1427221 aaataagaga gaacgccagg aattacttca gcagacgatt caagcaaccc cctttattac 1427281 agatgaagaa ctagcgggta aattcggggt gagcatccag acgatacgtt tggaccgctt 1427341 agagctttcc atacctgaac tgagagaaag aattaagaac gtggcagaga aaacacttga 1427401 ggacgaagtg aagtccctgt cacttgatga agttatcgga gaaattattg accttgagct 1427461 ggatgatcag gcgatatcca ttttagaaat aaaacaggag cacgtgttca gccggaatca 1427521 gattgcgaga ggacaccatt tatttgcaca ggcgaattct ttggccgttg cagtcattga 1427581 tgacgagctg gcgctgactg caagtgcaga catccgcttt acaagacagg taaagcaggg 1427641 tgaacgtgtc gtagcaaaag cgaaagtgac ggctgtcgaa aaagaaaaag gaagaacggt 1427701 tgtcgaagtg aacagctacg ttggcgaaga aattgttttt tctggacgct ttgacatgta 1427761 tcgttcaaaa cattcataaa ggtggagcat gcatgagaat agctgtagat gcaatgggag 1427821 gagaccacgc tcccaaagct gttattgacg gagttataaa aggtatagag gcatttgatg 1427881 atctccatat cacacttgtc ggtgacaaaa caacgataga atcacattta acaactacat 1427941 cagatcgcat cacggtgctg cacgcagatg aagtgattga gcctacggat gaaccggtcc 1428001 gtgccgtgcg aagaaaaaag aactcatcta tggttcttat ggcgcaggag gttgcggaaa 1428061 acagagctga cgcctgcatt tcagcgggaa ataccggtgc attaatgaca gccggtctct 1428121 ttattgtcgg gagaattaaa ggaattgacc gtccggcgct tgctccgaca cttccgactg 1428181 tttcgggaga cggatttctt ctccttgatg tcggcgccaa tgtcgatgcc aaaccggagc 1428241 acctcgttca atatgccatc atgggttctg tttattctca gcaagtgcgc ggtgtcactt 1428301 caccgagagt cggactttta aatgtcggaa cagaagataa aaaaggaaac gaactgacga 1428361 agcagacgtt tcaaatttta aaagaaacag caaacatcaa ttttatcgga aacgtggaag 1428421 cgcgagacct tttagatgat gtggcggatg ttgtagtaac agacggcttt accgggaatg 1428481 ttacactcaa aacgctggaa ggctctgcgt tgtcaatttt taaaatgatg agagacgtaa 1428541 tgacgtctac tttgacatcc aagcttgcag cagctgtgct gaaaccaaaa ttgaaagaaa 1428601 tgaaaatgaa aatggagtat tcgaattatg gcggagcaag tctttttggc ttaaaagcgc 1428661 ctgtgatcaa ggcgcacggc tcttcagatt caaatgctgt attccatgcg attcggcaag 1428721 caagagagat ggtcagccaa aatgtggctg cgctcattca ggaagaagtg aaagaagaaa 1428781 aaacagatga gtagtctgga ggtttttaca tcatgagtaa gattgcattt ttattcccgg 1428841 gtcagggatc acaatttatc ggcatgggaa aagagcttta tgagcaggtg cctgctgcaa 1428901 agcgtctgtt tgatgaagcc gatgaaacgt tggaaacaaa actcagctcg cttatttttg 1428961 agggggatgc tgaagaatta acacttacat acaatgcgca gcctgctttg cttacgacaa 1429021 gcatcgctgt tcttgagaaa tttaaagaat ctggcattac acctgatttc acagcaggac 1429081 acagccttgg tgaatattct gcactggttg cggctggcgc tctgtctttc aaagatgctg 1429141 tttatactgt cagaaagcgc ggagagttta tgaatgaagc ggtgccggct ggcgaaggag 1429201 caatggctgc gattctcggc atggatgctg aagcattaaa gcaagtaacc gataaagtca 1429261 cagaggaagg caaccttgta cagcttgcga atctcaactg tcctggccaa atcgtcattt 1429321 ccggaacagc taaaggggtt gagcttgcat ctgaactggc aaaagagaac ggcgcaaaac 1429381 gcgcaattcc gcttgaagta agcggtccgt tccattctga actgatgaaa ccggctgctg 1429441 aaaagctgaa agaggtattg gacgcctgtg acataaaaga cgctgacgtt ccggtcatct 1429501 caaatgtttc tgctgacgtg atgactgaaa aagcagatat caaagaaaaa cttattgagc 1429561 agctttactc tccggttcgt tttgaggaaa gcattaacaa gctgatcgca gagggtgtta 1429621 cgacttttat tgaaatcggt cccggaaaag tgctttcagg ccttgtgaaa aaagtgaata 1429681 gacggttaaa aacaattgct gtatcagatc cggaaacgat cgagctggca attcaaacgc 1429741 ttaaggagga gaatgataat gcttaatgat aaaacggcta ttgtcactgg cgcatcccgc 1429801 ggaatcggcc gctcaatcgc ccttgatctg gcaaaaagcg gagcaaatgt tgtcgtgaac 1429861 tactccggca atgaagcgaa agcaaatgaa gtggtagatg aaatcaaatc aatgggcaga 1429921 aaagcaattg ctgtaaaagc ggatgtatca aatcccgaag atgtacaaaa catgataaaa 1429981 gaaacattgt ctgttttttc tacgattgac attctggtta ataatgcggg aattacaaga 1430041 gacaatctca tcatgagaat gaaagaagac gaatgggatg acgtcattaa cattaacctg 1430101 aagggtgttt tcaactgcac aaaagctgtt acaagacaaa tgatgaaaca gcgttcaggc 1430161 cgcattatta acgtatcgtc tatcgtcggc gtcagcggaa accctggaca agccaactac 1430221 gtggctgcaa aagccggcgt catcggttta accaaatctt ctgctaaaga gctcgccagc 1430281 cgaaatatta cggtaaacgc aatagcgcca ggatttatct caactgatat gacagataaa 1430341 cttgcaaaag acgttcaaga cgaaatgctg aaacaaattc cgctcgcgcg ctttggtgaa 1430401 cctagcgatg tcagcagtgt tgtcacgttc ctagcttcag agggagctcg ttatatgaca 1430461 ggccaaacgc ttcatattga cggcggaatg gtgatgtaag ttttttctcg aaaatttcat 1430521 cgtagtttct ctagtttttt aaaaacgaat ccactataat acttgagggg aggtgaattg 1430581 ctatggcaga cacattagag cgtgtaacga aaatcatcgt agatcgcctt ggcgttgatg 1430641 aagcagacgt caaacttgaa gcttctttca aggaagactt aggtgctgat tccctagatg 1430701 tagttgagct tgttatggaa cttgaagacg agtttgatat ggagatttct gacgaagatg 1430761 ctgaaaagat tgcaacagtc ggcgacgctg tgaactacat acaaaaccag caataagctg 1430821 atgctaaaag tcccgccgaa acgcggggct ttagcccttt attcgtgcag ttattacagc 1430881 atgccgcttt tacgcgcgct gtatccggtt tagtcagaga agcgcggtga acctgatgtg 1430941 cctatggagg ttactatgtc aaaacactca cattataaag ataaaaaaaa gttctataaa 1431001 aaagtagaac aatttaaaga gtttcaagaa cggatttcgg ttcactttca aaatgaaaag 1431061 cttttgtatc aagcatttac acattcatct tatgtgaatg agcatcggaa aaagccgtat 1431121 gaagataatg aaaggcttga atttttaggt gacgctgttt tggaactgac gatctccaga 1431181 ttcttatttg ccaaataccc ggctatgagt gaaggagatt tgacgaaatt gagagccgca 1431241 attgtttgcg aaccgtctct cgtttcattg gctcacgagc tgtcattcgg cgatcttgtc 1431301 ctgttgggta aaggcgagga aatgacaggc ggaagaaagc gtcctgctct attggcggat 1431361 gtttttgagg catttatcgg agccttgtac cttgaccaag gattagagcc ggtcgaaagt 1431421 ttcttaaaag tttatgtgtt ccctaaaatt aacgatggtg ctttttctca tgtgatggat 1431481 ttcaaaagcc agctgcagga atacgtgcag cgggacggca aaggctctct ggagtataaa 1431541 atctccaacg aaaaaggacc tgcgcacaac cgtgaatttg aagccatcgt atctctaaaa 1431601 ggtgaaccac tcggagtcgg aaacggccgt tcaaagaaag aagccgaaca gcacgctgct 1431661 caggaagctt tagctaaatt gcaaaaacac catacgaaac aataaaatcc cccttatgac 1431721 tcagggggat ttcagtatgt atgccgtctt atttgaccaa tgtttatgat agaattgaaa 1431781 tacttattac ataaggagga tcgctatgtt cctcaaacgt ttagacgtta taggatttaa 1431841 atcatttgca gaacggattt ccgtagactt cgttaaaggc gtgacagcag ttgtcgggcc 1431901 gaacggaagc ggaaaaagca acatcacgga tgccattcgc tgggttctcg gcgaacaatc 1431961 ggcacgctct cttcgcggcg gaaaaatgga agacatcatt tttgctggga gtgattcaag 1432021 aaagcgatta aatctagctg aagttacgct tactcttgat aatgatgatc atttcttgcc 1432081 aattgacttc cacgaggtga gtgtcacaag acgtgtgtac agatcaggtg agagtgagtt 1432141 tctgattaac aatcagccat gccgcttgaa agatattatt gatttattta tggactctgg 1432201 gcttggtaaa gaagcatttt ctattatcag ccaagggaaa gtggaagaga tcctgagcag 1432261 caaagcggag gatcgccgca gtatctttga agaagcggcc ggggtgctta aatataaaac 1432321 gagaaagaaa aaagcagaaa ataaactgtt tgagacacag gacaatctaa atcgggtaga 1432381 agatatatta catgagcttg aaggacaggt tgaacctctt aaaattcaag cttcaatagc 1432441 gaaagactac cttgagaaaa agaaagagct ggagcatgtt gaaattgcgc tgactgccta 1432501 tgatatcgaa gagctgcatg gtaaatggtc gactcttaaa gagaaagtgc agatggcaaa 1432561 agaagaagag cttgctgaat cgtctgctat ttctgcgaaa gaagcaaaga ttgaggatac 1432621 aagggacaaa atacaagcgc ttgatgagtc agtagatgag ctccagcaag ttttactggt 1432681 aactagtgaa gagctggaaa agcttgaagg ccgtaaagaa gtcctgaaag aacgaaagaa 1432741 aaacgctgtg caaaaccaag aacagcttga agaagccatc gttcagttcc agcaaaaaga 1432801 aacggttctg aaagaagagc tttcgaagca ggaagctgtc ttcgaaacgc ttcaggctga 1432861 ggtgaagcag ttaagggcgc aagtaaaaga aaaacagcag gctctcagtc ttcacaatga 1432921 aaatgtcgaa gagaaaatcg agcagctgaa aagtgattat tttgagctgt taaacagcca 1432981 ggcttcgata cgcaacgaac tccagcttct tgatgaccag atgtcccaat ccgctgtcac 1433041 attgcagaga cttgcggaca acaatgaaaa gcacctgcag gaacggcatg atatttctgc 1433101 gcgtaaagcc gcatgtgaaa cggaatttgc ccgaattgag caggagattc acagtcaagt 1433161 cggtgcatat cgtgatatgc agacaaaata tgagcagaaa aagcgccaat acgaaaaaaa 1433221 tgaatccgct ctgtatcagg cataccaata cgttcagcaa gcgagatcaa aaaaggacat 1433281 gcttgagacg atgcagggag atttctccgg cttttatcaa ggtgttaaag aagtgctgaa 1433341 agcgaaagag cgccttggcg gaattcgcgg agcggttctt gagctgattt ctacagaaca 1433401 gaagtatgaa acggccattg aaatagcgct cggcgcttct gctcaacacg tcgtgaccga 1433461 cgatgaacaa tctgcccgca aagcgattca atatttaaag cagaattcct tcggccgggc 1433521 gacgtttctg cctctttctg ttattagaga ccgccagctt caaagccgtg acgcggaaac 1433581 agccgcccgg cattcatcat ttctcggggt tgccagtgaa cttgtcacat ttgatcctgc 1433641 gtatcgaagc gtcatccaga atcttcttgg aaccgttctg atcacagagg acttaaaggg 1433701 tgcaaacgag cttgcgaagc ttctcgggca ccggtaccgc atcgtaaccc ttgagggaga 1433761 tgttgtgaac cccggtggtt caatgacggg cggcgcggtt aaaaagaaaa ataactccct 1433821 ccttggaaga agccgggagc tagaagatgt gacgaaacgg ctcgctgaaa tggaagagaa 1433881 aacggcactg cttgaacaag aggtcaaaac ccttaagcac tccattcagg atatggagaa 1433941 aaaactggct gacttaagag aaaccgggga aggcttaagg ttaaagcagc aggatgtgaa 1434001 aggccagctg tacgaacttc aagttgccga gaaaaatatc aatacccatt tagagctcta 1434061 tgatcaagaa aaatctgctc tgtcagaaag cgatgaagag agaaaagtgc gcaaacgcaa 1434121 gcttgaagaa gagctctctg ccgtatctga aaagatgaaa cagcttgaag aggacataga 1434181 cagactgaca aaacaaaaac aaacgcaatc ctcaacgaaa gagtctctct ccaacgagct 1434241 gactgagctg aagatcgcag cggccaaaaa agagcaggct tgcaaggggg aagaggacaa 1434301 ccttgccaga ttaaagaaag agctcactga aacagagctt gcgttaaaag aagcaaaaga 1434361 agacttaagc ttcttaacgt cagagatgtc atctagcacc agcggcgaag aaaagctgga 1434421 agaagcagca aaacataaat tgaatgacaa aacgaaaacg atcgaactga ttgcattaag 1434481 gcgcgatcag cgcatcaagc ttcagcatgg gcttgatacg tatgagcgtg agctgaaaga 1434541 aatgaaacgc ctgtataaac aaaaaacaac gctcttaaaa gacgaagaag tcaaacttgg 1434601 acgaatggaa gtcgagcttg ataatttact ccaatactta cgggaggaat acagcttgtc 1434661 ctttgagggg gcaaaagaga aatatcagct tgaaactgat ccagaggaag ccagaaagcg 1434721 cgtgaagctg attaaactcg caattgaaga gctgggtacc gtgaacctcg gaagcataga 1434781 tgagtttgag agggtcaacg aacggtacaa gtttctgtcg gaacaaaaag aagatttaac 1434841 agaagcgaaa aataccttgt tccaagtgat tgaagaaatg gatgaagaaa tgacgaagcg 1434901 ctttaacgac acattcgtcc aaatccgctc acactttgat caagttttcc gctccttatt 1434961 cggaggaggg cgagctgaac tgaggctcac cgatcctaac gatctgcttc attcaggagt 1435021 cgagattatc gctcagccgc cggggaaaaa gctgcaaaac ttaaacctcc tgtcaggcgg 1435081 agagcgtgcg cttactgcta tagcgctctt attctcaatc ctaaaggttc gtccagtgcc 1435141 gttttgcgtc cttgacgaag tagaggctgc gctcgacgaa gcgaatgtgt tccgatttgc 1435201 gcagtattta aaaaaataca gcagcgatac tcagtttatt gtgattaccc acagaaaagg 1435261 aacgatggag gaagcggatg tgctttatgg cgtaaccatg caggaatccg gtgtttccaa 1435321 ggtaatttca gttaagctgg aagaaacaaa agaattcgtt cagtaacgag gaaagaggtt 1435381 aaaagatgag cttttttaaa aaattaaaag agaaaatcac aaaacagaca gattccgtat 1435441 ctgaaaagtt taaggatggc cttgaaaaaa caagaaactc ctttcaaaac aaagtgaatg 1435501 atcttgtatc ccgttaccgt aaagtggatg aggatttctt cgaagagctt gaagaggttc 1435561 ttatcagcgc ggatgtcggt tttacaaccg ttatggaatt aatagatgag ctgaaaaaag 1435621 aagtcaaacg cagaaatatt caagatccaa aggaagtcca gtcagtgatt tctgagaaac 1435681 tggtcgagat ttataacagc ggagatgagc aaatttcaga actgaacatc caggatgggc 1435741 gtttaaacgt aatccttctg gtaggtgtaa acggcgtcgg gaaaacaaca acgatcggaa 1435801 agcttgctca taaaatgaaa caagaaggaa aatctgttgt acttgccgcc ggagacactt 1435861 ttagagcggg agccattgaa cagctggaag tatggggaga gcgtacagga gtgcctgtca 1435921 ttaagcagac ggcaggaagc gatccggcgg ctgtcatcta cgatgctgtt catgctgcga 1435981 aagcaagaaa tgccgatgta ttaatttgtg atacggcagg gcgtctccaa aacaaagtaa 1436041 atctcatgaa agagcttgaa aaagtaaaac gtgttatcga aagagaagtt cctgaagctc 1436101 cgcatgaggt gctgcttgcc cttgatgcca cgaccggcca aaatgcaatg gctcaggcaa 1436161 aagaattctc taaagcaaca aatgttaccg gcattgcttt aacgaagctt gacggtacgg 1436221 caaaaggcgg tatcgtcctt gcgattcgca acgagcttca catcccggtt aaactagtcg 1436281 gtttaggaga aaaagttgat gaccttcagg aatttgatcc agaatcctat gtgtacggac 1436341 tcttttcaga tttagtggaa aaagccgacg attaagaaaa aggccccaac atcttggggc 1436401 ctttttcttt tttatcttct tacttgatag gcgaaatgat aaaggctgtt atcagtggat 1436461 accagtcttg actcaccaga aaaaactctg aatgggatga tgtcatagta atgaacggaa 1436521 acagatgtgt aatacgtata gtaaccagca gctggcccca aatacattgg aacctcaaat 1436581 gttccgtttg catcagtcgt tcctgaagca gtttgtgttg tgtttccgac cttcgtgtcc 1436641 gcttcaaatc ttacgggcgc gtttggcact ggctgtccgt tttggtcgag taatttgccg 1436701 cttactgtaa tattgtactt gactcgccaa tattgacctt gtccgtaatt gattttaccg 1436761 tatacccctc catctgtgct gatatttgtg attgaggcct tataaggtgc ctcagcagcg 1436821 tctgcttgct gtgccgggaa acctattgta aacagggctg ccagacataa cataaacaat 1436881 aaaccgattt ttttcataaa aatcctcctt aaaatagggt tcatatacaa tatcggaata 1436941 aattggatga tatttagcgt attttggaaa agttaatcgc cgctttgaca agataaaaac 1437001 ttgacagtgt cattaaaacc gtgtaaacta agttatcgta aagggatttg acttaacaaa 1437061 ggggagagct caaatgtcac tcgaaaagac aacgagaatg aattatctgt ttgattttta 1437121 tcagtcgttg ttgacgtcaa aacagaagag ctatatgtcg ctttattatt tggacgattt 1437181 ctccctaggc gaaatagccg aagaatatga ggtttcaaga caagctgttt atgataacat 1437241 caaacgaaca gaagcaatgc ttgaacaata tgaagaaaag ctgctccttt tgaaaaagtt 1437301 tcaggagcgt aaagagatgt ttaataagct gaaggagctt gcttccggtt caaaagaaga 1437361 ggaagaaatt acagctctga ttgaagcgct tgagaaatta gattaggagg cggcaaacta 1437421 tggcatttga aggattagcc gaccgactgc agcagacgat ttctaaaatc cgcggaaaag 1437481 ggaaagtcag cgaacaagat gtaaaagaga tgatgcgtga ggtccgtctt gcgctgcttg 1437541 aggctgacgt taactttaaa gtagtcaagg attttgtcaa aaaagtaagt gaacgcgctg 1437601 taggccaaga cgtcatgaaa agtctgacgc ccggccagca ggtcattaaa gttgttcaag 1437661 aggaactgac tgagctgatg ggcggcgaag agagcaaaat cgccgtcgca aaaaggccgc 1437721 cgactgttat tatgatggtc ggtctccaag gtgccggtaa aacgacaaca agcggtaagc 1437781 ttgcgaatct gctgcgcaaa aagcataatc gcaaaccgat gctggttgct gccgatattt 1437841 accgcccagc cgcaattaag cagctggaaa cactcggcaa acagcttgat atgcctgttt 1437901 tctctcttgg cgatcaggtc agtcctgtag aaatagctaa acaggctatt gagaaagcca 1437961 aggaagaaca ttatgactac gtcattttgg atacggcagg gcgcttgcat atcgaccatg 1438021 aactgatgga tgaactgacc aacgtcaaag aaatcgcgaa tccggaagaa attttcctgg 1438081 ttgtcgattc aatgaccggt caggacgctg tgaatgttgc caaaagcttt aatgaacagc 1438141 tcggtttaac cggtgttgtg ttgactaagc tggatggaga cacacgcggc ggggctgcgc 1438201 tttctattcg cgctgtcaca aacacgccaa ttaagtttgc aggtttgggc gaaaagcttg 1438261 atgcgttaga gccgttccat cctgaacgca tggcatcaag gattctcggc atgggcgacg 1438321 tgctgacatt gattgaaaaa gcacaggcca gcgttgatga agacaaagcc aaagagctgg 1438381 aacaaaaaat gagaacgatg agcttcacat tggacgattt tctggagcag ctcgggcaag 1438441 tcagaaacat ggggccgctt gatgagcttc tgcaaatgat gccgggtgca ggtaaaatga 1438501 agggcctgaa aaacatccaa gttgatgaaa aacagctgaa tcatgtggaa gcaatcatca 1438561 aatcaatgac tgttcttgaa aaagaacagc cggatattat caatgccagc cggcggaagc 1438621 ggattgcaaa aggaagcggg acatccgtac aggaagtcaa ccgtctgctt aagcagtttg 1438681 atgaaatgaa aaaaatgatg aagcagatga caaacatgtc aaaaggcaag aaaaaagggt 1438741 ttaagctacc ttttatgtaa tcggttatac atgataaaac cgttgttaag aaaaaacact 1438801 ttacaaacac ttttatcatt gttaatatac tatcttgttg aaatattttc ggaggtgcta 1438861 gtaaaatggc agtaaaaatt cgtttaaaac gtatgggagc aaaaaaatct cctttctatc 1438921 gtattgttgt agcagattct cgttcaccac gtgacggccg tttcatcgaa acagtcggaa 1438981 cttacaaccc ggttgcaaaa ccagcggaag taaaaattga cgaagagctt gctcttaaat 1439041 ggcttcaaac tggagcgaaa ccatctgata cagttcgcaa cttgttctct agccaaggaa 1439101 tcatggaaaa attccacaac gctaaacaag gcaagtaatg actgatcaac acttggaaga 1439161 tttgattgtc cacattgtga cgccgcttgt tgatcatcca gatgacattc gcgtcataag 1439221 agaagaaacc gatcaaaaga ttgcgctgcg cttatctgtc cataagtcag ataccggtaa 1439281 agttatcgga aagcaaggcc ggactgcaaa agcgattcga acagctgtat ttgcagctgg 1439341 cgtacagtct tctaagaaag ttcaatttga aatatttgac taaaagggag agggccggca 1439401 cctccccttt ttttacacgc aaaaaaaggg taaactgata gaagcttagg caaaatagaa 1439461 aagcctggac gagtaaaagt tttaaaagcg gggagcttgg tgcgatgcaa attattcacc 1439521 gtgtagccgt tatgcaagtc ttaaccgagc gcagtaaaga aaagctttta gcttcttttg 1439581 ctgagaagaa acaaatgctt gaacgagaat gcagccagct ctattttcag cttagaaaac 1439641 atgagaaaga acagcaaaac cctaatatga ttgaacaatt taaaaaggca atagaaaagc 1439701 gaaaagatga tataaaaatc attgattttc aaattgctca agtacataca ttgccgcttg 1439761 gcagtgagtt gaaagaaaag gaagtcgatg cgctgctgac gattgaagcc ggggatgact 1439821 ggcatgagaa aacagcagcg aacaccatcg tcataaaaga cggaaaagta attgaaattc 1439881 gccagaggtg atcatatgac aaagcgatgg tttaatgtag gcaaaatcgt aaatacccac 1439941 ggaatcaaag gcgaagtgcg ggtgatttca aaaacagatt ttgccgaaga acgatacaag 1440001 ccgggaaaca cgctgtattt gtttatggac ggccgtaacg aaccagtgga ggtaacggta 1440061 aacacacata gactgcataa gcaatttcat ctcctgcagt ttaaagaaag acaaaaccta 1440121 aatgaagtag aagagctgaa aaacgcaatc attaaagttc ctgaagaaga attaggagag 1440181 ctgaatgagg gtgaatttta tttccacgaa attattgggt gtgaagtatt tactgaagaa 1440241 ggcgaactca tcggaaaggt caaagaaatt ttgacgcctg gagccaatga cgtttgggtc 1440301 atcggacgaa aaggaaaaaa agacgcactc attccttaca ttgaatcagt ggttaaacat 1440361 atcgatgtca gggaaaagaa aattgagatt gaactcatgg aagggttaat agacgaatga 1440421 aaatcgattt tttgacgctg tttcccgaaa tgtttgaagg cgtgctcggc tcatcgattc 1440481 ttcaaaaagc ccaggaaaaa gatgcggtgc agtttcaagt cgtaaatttc cgagagtact 1440541 ctgataacaa gcacaatact gttgatgatt atccttatgg cggcggggca ggcatggttc 1440601 tcaagcccca gcctgttttt gacgcggtcg aggacctgac atcaaaggca gccgctgctc 1440661 cgcgtattat cctcgtatgc ccgcaaggtg agcgttttac ccaaaaaaaa gccgaacaat 1440721 tagctaagga agagcatttg ctgttcattt gcggccacta tgaaggctat gatgaacgca 1440781 ttcgcgagca cttggtaacg gatgaaatat caattggcga ctttgttctg acgggcggtg 1440841 agctccctgc aatgatgatc gcagacagtg tggtcagact gcttccgggt gtactgggta 1440901 aagaggcttc ccatattgag gattccttca gcaccggact tttagagcac ccgcattata 1440961 caagaccggc agattacaaa ggtttaaaag tgcctgaaac actcttgtca ggaaaccatg 1441021 caaaaattga agaatggcgg aataaagaat cgatcagaag gacctaccta agacgtccgg 1441081 atctgttgaa agaccacccg cttacagagc agcaaagaaa gtggatttct gaatgggaaa 1441141 aagaatagat tttattgcat aggctatgaa attgtgataa gatactactt gtggcttaag 1441201 cgggcttatc cgctgcaagc ttgaaaacga tgttccgctg tgccggtttt tgtggccaag 1441261 agcatctgtt ggaaggagtt gaaaacgatg caaaaactaa ttgaagatat cacaaaagaa 1441321 cagcttcgta ctgatcttcc tgcgttccgt cctggtgaca ctttacgtgt acacgttaaa 1441381 gttgttgagg gtaaccgtga gcgtatccag atctttgaag gtgttgtgat taagcgtcgt 1441441 ggtggtggaa tcagcgaaac gttcacagtt cgtaagattt cttacggtgt tggcgttgaa 1441501 cgtactttcc cagtacacac accaaaaatc gcgaaaatcg aagttgtacg ttacggtaaa 1441561 gtacgccgtg ctaaacttta ctacctgcgt gaacttcgcg gaaaagcggc tcgtattaaa 1441621 gagatcagac gataatgata acgaacgaaa agagcttgtt acctgtaaca agctcttttt 1441681 ttatacagaa tttgaaaatg ccggacaggc atcgtaaaat acataaagga caacaatgaa 1441741 tcatgcatac tgaagataaa ggcggtgttc gtgtcacatg acaattcaat ggttcccggg 1441801 ccatatggca aaagcaagaa gggaagtaac cgaaaaatta aaattaatcg atatcgtata 1441861 tgaattggta gatgccagaa ttccaatgtc atcaagaaac ccaatgattg aagatattct 1441921 aaaaaacaag ccgcgaatta tgctgttaaa caaggctgac aaagcagatg cggcagttac 1441981 acagcagtgg aaagagcact ttgagaacca ggggatccgc tctctgtcta ttaattctgt 1442041 aaatggacaa gggttaaatc aaattgtgcc tgcatcaaaa gagatcctcc aagaaaaatt 1442101 tgaccggatg cgtgcgaaag gtgtgaagcc gagagcgatt cgcgctttga ttatcggcat 1442161 tccaaacgtc ggaaaatcaa cgctcatcaa ccggcttgca aagaaaaaca tagcaaaaac 1442221 gggagacaga cctggtatta cgacttctca acagtgggtc aaagttggga aagaattaga 1442281 gctattagat acaccgggaa ttttgtggcc taaatttgag gatgagcttg tcggtttgag 1442341 actggcagtc accggggcta ttaaagactc gattatcaat ttgcaggacg tggccgtgtt 1442401 tggtcttcgt tttctcgaag aacattaccc agaacggctt aaagagcgtt atggccttga 1442461 tgagatccca gaggacattg ccgagctgtt tgatgcaata ggtgaaaagc ggggctgtct 1442521 catgagcggt gggctcatca actacgataa gacgactgaa gtcatcattc gcgatattcg 1442581 cactgaaaag ttcggcaggc tgtcatttga acagccgacg atgtaaaggc gcgcagaaat 1442641 gcgggtcttt attttttctt ggctgaaccg atacatacag taagggagaa gagaaagtga 1442701 atacattaac cgtaaaggac attaaagacc gtttgcagga agtgaaggat gcacaagacc 1442761 catttattgc ccaatgcgaa aacgacccga gaaaaagcgt tcaaacgctt gtagagcaat 1442821 ggcttaaaaa gcaagcgaaa gaaaaagcgc tgaaagaaca atgggtgaat atgacttcct 1442881 atgaaaggct ggcaagaaac aaaggatttc gcttgattgc aggtgttgac gaggtcggcc 1442941 gggggccatt ggcaggacca gttgtcgcca gcgcagtcat ccttccagag gaatgtgaaa 1443001 tacttgggct gacagactcc aaaaagcttt cagagaaaaa acgcgaggaa tattacgagc 1443061 ttattatgaa ggaagcactg gcggtcggga taggaattgt agaagctact gtgattgatg 1443121 agatcaatat atatgaagct tcaaaaatgg caatggtgaa agcgatacag gatttgtcgg 1443181 atacacctga ttatttgctt gttgacgcaa tgacacttcc gctcgacacg gctcaggcgt 1443241 caattataaa aggcgatgcc aaaagcgtgt ctattgcggc aggtgcgtgt atcgcaaaag 1443301 tgacgaggga ccgaatgatg agcgcttatg ccgaaacgta tcccatgtac ggctttgaaa 1443361 aaaataaagg ctatgggaca aaagaacatt tggaagctct cgctgcatac ggcccaactg 1443421 aattgcaccg caaaactttc gctcctgttc aatctttcag ataaatcacc atggacaagg 1443481 aggcaccttt ttaaaatgaa catacgaaat gatgtgcaaa aggcgctgca gcaccttttc 1443541 gggcgtacag ccgtcccgca ggaaacatca aaagtaaacg aagcgctaaa cggggagaag 1443601 cgtctcctct taggaaaagt gcttcgttta ctaggagatc agcatgccct gatccaagtc 1443661 ggcaatcaaa ctgttcaggg aaaacttgaa actcagcttc gtcctcaggc atactattgg 1443721 ttttcctacg aaaaaaaaac ggcagagcaa acaggccgtc ttcaggtcgt tcaaagcttt 1443781 gatcaaaatc ctaaaaccat tcaggatgca gctggcaaac ttttaaatgc tatttcagtg 1443841 aagacgtcaa acgcagctct catgatgaca ggagcgatgc tgaaaagcaa aacacccgta 1443901 acagaaaatg atatcaaaac agctgtccgc tggatggaca cgctgccttc gcaagacaca 1443961 aaaaaagcag ttgaaacggt tctcttcgct ttaaagcgtg atcttcccat tcactccgag 1444021 attttgaatg gtgttcacgc tgtgaaatcg cctgttccgt tgcatcagca cgtatcccag 1444081 ctgctacagg caatcgacca aaaccctcag cagagccaaa tgatgtcaaa gctaaaggaa 1444141 gcagtcacgg tgcttttaaa tagtgaaatc gatgtccatg cagaacggct gattgataag 1444201 cttatttctt taaccgacaa tacgaaagca ccttctccga cgaatacagc tggaagcagg 1444261 gagcttagca caccagctgg ctcccccgga aaagccagcc tgccgattgc aaatcacaca 1444321 gcagaacagg gaagcataca agaagagcct gttaaaacag cagcagacat tccaattaaa 1444381 gaagcccgcc agctgctggt gaagctgacg gaatctgctg aaaaaaacag tctccaaatt 1444441 gtgaaagaag cagcaaattg gattaaagcg gctgcttcat cgggtgatag taagtcactt 1444501 gcagcttcag ctgttttaca ggcggcacaa gtcacagatc aggaagccga agtcttttta 1444561 aaggctgttc agcagacagc accccatttg gcggataagg cagatgttct ttctttctta 1444621 tccaaagtga aaacggcaat cggcgcaagg gacgaggttg cgttcattaa agcgtttgaa 1444681 caaggaagcg cagtcacatc tggcgaaatg caatccatca agctggctct ttctgcctta 1444741 agagcatcgc atgaggtagc cgaaccagtc aaacaagaag ccgatcagct ttttcataaa 1444801 ttaaatggcc agcttttcat gcagcaggac catccatcat acagccaaat tgtaatgtca 1444861 tttccgatgt tttcgaagtc aggggttcag gacatgactg ttctgtttaa aggaaagaaa 1444921 gaagcggatg gaaagcttga tccttcccat tgccgccttt tgtttttgct gcagcttgat 1444981 acactaaaag aaaccgtcgt tgattgcttg gtacagcaaa aagtcatgac cattacaata 1445041 gagactgatt tcgagctgca ggctgcgatc gatccgatgg tgcccgcgct taaacagggg 1445101 ctaaaggaaa tggggtacag cctttcaggg gtaaacgcta aaaaaagggt tcacaccgaa 1445161 gaaaaggctt caatcgatca atatataaca agtatcagtg atcaggaagt ggatgtgaaa 1445221 atatgaaaga gcagacaccg atcagaaaag ctgttgctct ccattatgac gaacaaaaag 1445281 acaaggcgcc gagagtgatt gccacaggga agggccatgt agctgacaac attataaaag 1445341 aagcgaaaaa agcaggggtc ccgattcaag aagatcggac ccttgtcgaa ttaatgcgcc 1445401 atttgacggt agatgatcaa attcctgaag ctctttatga aacggtagcc gagatttttt 1445461 cattcattta caaattggac gaaagcgtaa aaaacaaaaa atagctaaaa tattccccat 1445521 ccttctttga aatttatgtt tttaataaag taaaagtttg aatgtttaga aggattaaaa 1445581 gattttgcat cgaactgtag acaattcttc cagtattatt atagaatgaa agcgcagtct 1445641 attttagttt tgttacataa gttaggagga tgggaaatga atatccatga gtaccaggga 1445701 aaagaagtcc tcagaaaata tggggtatct gttcctgaag gtaaagtggc ttttacagca 1445761 gaagaagcag ttgagagtgc aaagagctta tccagctcgg tttatgtcgt aaaggctcaa 1445821 attcatgctg gcggtcgagg caaagctggt ggggtaaaaa tagcaaaatc attagacgaa 1445881 gtaaaagcgt atgccgaaga actattaggg aagaccctag ttacacatca gacgggtccg 1445941 gacggccaag taataaaacg cttacttatt gaagaaggct gcgatattaa aaaagaatat 1446001 tacatcggtc tagtgcttga ccgcgccact tcaagaatcg ttttaatggc ttctgaagaa 1446061 ggcggaacgg aaattgaaga ggttgcggag aaaacaccag aaaaaatcaa aaaagctgtc 1446121 attgatccag ctgttggcct tcaaggctat caagccagag aaattgcatt cgctattaat 1446181 attccaaaag agctcgtggg aaaagctgct aaatttatgc ttggactata taaagcgttt 1446241 gttgagaaag actgctcaat cgccgaaatc aatccgcttg ttgtgactgg cgacggaaat 1446301 gtgatggcgc ttgatgcaaa attgaatttt gacagcaatg cgttgtaccg acaaaaggac 1446361 attatggaat acagagattt ggatgaagaa gatccgaaag aaattgaagc gtccaaatat 1446421 gatctaagct acatttccct tgatggaaat atcggctgta tggtaaacgg cgcgggactt 1446481 gcaatgtcta cgatggatat tatcaagcat tatggaggag aaccggccaa cttccttgat 1446541 gtgggcggcg gtgcaaccgc ggaaaaagtc acggaagcat ttaaaatcat tctttctgat 1446601 caaaacgtta aagggatttt tgtcaacatt ttcggcggca ttatgaaatg tgatgtcatc 1446661 gcagaagggg ttgttgaagc gactagacaa gttggtttga cattgccgct tgtcgtccgt 1446721 cttgaaggca caaacgtgga tctagggaag aaaatcctta gtgaatcagg attaaacatt 1446781 acatctgcgg aatcaatggc tgacggcgcg cagaaaatcg tatccttagt ttaagaaaga 1446841 atgaaaggca ggggaccaaa taatgagtgt tttcattaat aaagatacaa gagttattgt 1446901 gcaagggatt acaggttcta ccgctttatt tcatacgaag cagatgcttg aatacggcac 1446961 aaatatcgtt ggcggtgtaa cacctggaaa aggcggaaca gaagcggaag gtgttcctgt 1447021 atttaataca gtggctgaag cagttcaaac aaccggcgct aacgcgtctg ttatatatgt 1447081 gcccgcaccg tttgcagctg atgcgattat ggaagcggta gatgcggagc ttgatctcgt 1447141 gatttgtatc acagaacata tcccggtttt ggatatggtg aaggtcaaac gcttcatgga 1447201 aggcaagaaa acgagactga tagggccgaa ctgtcctggt gtcattacgc ctgaagaatg 1447261 taaaatcggc attatgcccg gatacatcca taaaaagggt catgtaggcg ttgtatcacg 1447321 ttcaggaaca ttaacatacg aagcggtgca ccagctctca gaagcgggtg tagggcaatc 1447381 tacagctgtt ggaatcggcg gcgaccctgt aaatggaaca aactttattg acgttttaaa 1447441 agcgtttaac gaagatcctg acacacacgc agtcatcatg attggcgaaa tcggcggtac 1447501 ggccgaagag gaagcggcag agtgggtaaa agccaacatg acaaaaccgg tagtcggttt 1447561 tattggcggt aaaacagcac ctcctgggaa gcgcatgggg catgcaggcg ccattatttc 1447621 cggcgggaaa gggacagctg atgaaaaaat caaaaccctt aatgcatgcg gaatcgaagt 1447681 tgcagagaca ccttctgtca tgggtgaaac cttaatcaag gtgctgaaag agaagaactt 1447741 gttcgaaact tgtaaaacgc attaataaaa aagggacagc cgtcaaggct gttcctgctt 1447801 tttctaacaa aaggaggtca atctattgga tcaggccgct gtctgcctaa cgatttgcag 1447861 aatcaatcaa ttattatccc catcccttct attaaaatgg tggaaagccg atccgtctat 1447921 gtcgctgaca tcacccgtgt tacaaacggt tactcgtgat caaataaaag cagctgcatt 1447981 aaaaaacgaa atagaacaat tttatccaaa gctcccgcgt gtacttgctg cttatcgtga 1448041 gcaaggcatt aacaccatcc ctatttcttc aaagcaatat cctttctggc ttaaaagcat 1448101 ttatgatccc cctgccgtac tgtttgcaaa aggtgatatg actcttcttt cgaaagggag 1448161 aaaaattgga attgtaggca caagaaatcc aacagcttat gggaaacaag ttgtcaatca 1448221 tcttacaaaa gagatctgtc gtaaaggttg ggtgattgtc agcggactgg cgtctgggat 1448281 agacggaatg tcccatgctg caagtattaa ggcgaagggg cggacaattg gcgtcattgc 1448341 aggcggattt caacacattt atccccgaga aaaccttcag ttagcagatc acatggctaa 1448401 acaccatatc ctgctgtcag agcacccacc tgaaactaaa ccccaaaaat ggcatttccc 1448461 tatgagaaac cgtattatca gcggactaag tgaaggcgtt attgtcgttc agggcaaaga 1448521 aaaaagcggt tcgctgatta ctgcctatca agcattggaa caagggagag aggtatttgc 1448581 cgtacccggt tcattgtttg acccttacgc cggaggtcct ataaaactga tccagcaggg 1448641 ggctaaagcc atatggtcag cagaggatat tttcgaggaa cttcctgaga gaaacgttca 1448701 atatacggaa cccttttgaa ttatcgtttg acaaacggta ttgtaatatt taataatagt 1448761 gaggatttaa agttgcatat tgttttctat ttaattaatg acgttcatga taaagaatga 1448821 aatgttgaaa gccaaataaa gacagctgca aaaataaaat tgaaatatct tgaaaagaga 1448881 gagaacacct cttgaggggg atgaaaatgt ctgattatct agtcatcgtg gaatcgcccg 1448941 ctaaggcgaa aacgattgaa cgttacttag gtaaaaaata taaagtaaaa gcatcaatgg 1449001 gacatgtccg ggatcttcca aaaagtcaaa tgggagttga catagaacag aattttgaac 1449061 cgaaatatat taccattcga ggtaaaggcc cggtattaaa agagctgaaa acggctgcga 1449121 aaaaagccaa aaaagtgtat ctcgcagctg accccgacag agaaggggaa gcgattgcat 1449181 ggcatttggc acacagtctt gatttagatc tcaactcaga ctgccgtgtg gtgtttaacg 1449241 aaattacaaa agacgctatt aaggaatcgt ttaagcatcc ccgcatgatc aatatggatt 1449301 tagtggatgc acagcaagcg agacgtattt tagacaggct tgtcggatat aaaatcagtc 1449361 caatcttatg gaaaaaagtc aaaaaagggc ttagcgcagg acgcgtgcaa tccgttgccc 1449421 tccgtttgat tattgaccgt gaaaaagaga ttaacgactt taagcctgag gaatattgga 1449481 caattgacgg tacgttctta aaaggtcaag aaacctttga agcgagcttt ttcgggaaaa 1449541 acggcaaaaa acttccttta aatagtgaag ctgatgtaaa agagattctt tctcagctca 1449601 aagggaatca atatacagtt gaaaaagtaa ccaaaaagga acgcaaacgt aatcctgctt 1449661 tgccttttac cacttctacc ctgcagcagg aagcggctcg caagctcaat ttcagagcga 1449721 agaaaacgat gatgattgca cagcaattat atgaaggaat tgatttagga agagaaggaa 1449781 cggttggtct gatcacgtat atgagaacgg attcaacccg tatttcaaat acggctgttg 1449841 atgaagcagc tgcatttatt gatcagacat atggaaaaga gttcctaggc ggaaaacgga 1449901 agcctgcgaa aaagaatgaa aatgcccagg atgcccacga agcaattcgg ccgacatcag 1449961 ttcttagaaa accaagtgaa ttaaaagcag tcctcggcag agaccaaatg agactgtata 1450021 aattaatttg ggagcgtttt gttgccagcc aaatggcacc ggctgttctc gatacaatga 1450081 gtgtcgacct gacaaacaac ggtttgacat ttcgtgcaaa tggaagtaaa gtcaagtttt 1450141 ccgggtttat gaaggtgtat gttgaaggaa aagacgatca aatggaagaa aaagaccgga 1450201 tgctgcctga cttacaagaa ggcgacacgg tattatcaaa agatatagaa cctgagcagc 1450261 attttaccca gccgcctccg cgatatactg aggcccggct tgttaaaacc cttgaagaac 1450321 gcggtatcgg ccgtccatcc acatatgctc cgacacttga tactattcag cggcgcggct 1450381 acgtggcatt ggataataaa cgtttcgttc cgactgaatt aggtcagatc gttcttgact 1450441 tgatcatgga gtttttccct gagatcatta acgttgagtt tacagctaaa atggagagag 1450501 atcttgatca tgttgaagaa ggaaataccg aatgggtcaa gattatcgat aatttctaca 1450561 ccgattttga aaaacgcgtc aaaaaagccg aatcggaaat gaaggaagtt gagattgaac 1450621 cagagtatgc tggagaggat tgtgaattgt gcagttctcc aatggtatat aaaatgggac 1450681 ggtacggtaa attcttagct tgctccaact tccctgactg ccggaacacg aaaccgattg 1450741 tgaaacaaat cggtgtgaag tgcccgagct gcggagaagg aaacattgtt gagcgaaaat 1450801 cgaaaaagaa acgggtgttt tacggctgtg accgttatcc ggactgtgaa ttcgtatcat 1450861 gggacaaacc aattgaacga aaatgcccga aatgcggaaa aatgctcgtc gagaaaaaac 1450921 tcaaaaaagg tatacaagtc caatgcgtgg aatgcgatta taaggaagaa ccacagaagt 1450981 agcggtgagc agggtcttgc tcaccttctt tgtgtgttaa aagaaggcct tgaataataa 1451041 actaggagat gtgaaagatg aaccaacaaa cagtgaatgt aatcggagcc ggactcgcag 1451101 gaagtgaagc agcatggcag cttgccaaac gtgggattca agtcaaattg tatgaaatgc 1451161 ggccagttaa acaaacgcct gcgcatcata cagataaatt tgctgagctt gtctgcagca 1451221 actctcttcg ctctaataca cttgctaacg ctgtcggtgt attaaaggaa gaaatgcgtg 1451281 cgcttgattc agccattatc gctgcggctg acgaatgttc ggtgcctgcc gggggcgctc 1451341 ttgcagtaga ccgtcatgaa tttgccgcaa gtgtgacaaa tcgggtgaaa aatcatccaa 1451401 acgtaaccgt tattaatgaa gaagtgactg aaattcctga aggccctact atcatcgcaa 1451461 cgggtccgtt aacatctgaa tcgctgtctg cccagctgaa ggagctgact ggagaggact 1451521 atttatattt ttatgacgca gcggcgccaa ttgtagaaaa agacagcctt gatatggata 1451581 aagtgtacct gaaatcccgt tatgataaag gtgaagcagc atatttgaac tgcccgatga 1451641 cagaagaaga gtttgaccgt tttcatgaag cattaacatc agcagaaaca gtgccgttaa 1451701 aagaatttga aaaagagatt ttctttgaag gctgcatgcc gattgaagtc atggcaaaac 1451761 ggggtaagaa aacaatgctt ttcggtccga tgaaaccagt tggtctagag catcctgtta 1451821 caggaaaacg cccttatgcc gtcgttcagc tcagacagga tgatgctgcg ggaacacttt 1451881 ataatattgt aggattccag acacatttaa aatggggaga ccaaaaggaa gttctcaagt 1451941 tgattccagg acttgaaaat gtagaaatcg tcagatatgg cgtgatgcat agaaacacat 1452001 ttattaactc tccaagcctg ttaaagccga cttatcaatt taaaaaccgc agtgatctgt 1452061 tctttgcagg ccaaatgacg ggagtagaag gatatgtgga atcagctgcc tcaggacttg 1452121 tagcaggcat taatgcggcg aagcttgtat tgggagaaga gcttgtgatc ttccctcagg 1452181 aaacagcaat tggcagtatg gcacattata ttacaacaac aaaccagaag aacttccagc 1452241 cgatgaatgc aaactttggg cttttgaaag aattgccagt taaaattaaa aataaaaaag 1452301 aacgaaatga acaatacgcg aaccgtgcga ttgaaacaat tcaaacaatt tcgaaaacaa 1452361 tataggtatt gattgcaacc tgagcgcgat ttgtgatacc atttaaaagc ccttcctggg 1452421 gaggtattag gcatggagaa tgttaagaat ttcgtaaagt tattcgttga atatttacaa 1452481 attgaaaaaa attattcaca atatactatt gtgaattatg tggattcaat tgaagaattc 1452541 gagactttcc tgcgcgttca aggtataaat ggatttgaag aagctgcata tcaagatact 1452601 aggatttttt tgacagaagc ctatgaaaaa ggtttatcga gaagaacaat aagcaaaaag 1452661 atatctgcat taagaagctt ttataagttt ctgatgcggg aaaagcttat tgaagaaaat 1452721 ccgtttcagc ttgttcatct gccaaaacag gagaaacgga taccgaagtt tctatatcaa 1452781 aaagagcttg aggagctgtt tgaagtttca gatataagcc agccggccgg aatgagggat 1452841 caagcgctgt tagagctgct ctatgccact ggaatgaggg tcagtgaatg ctgttccata 1452901 actattaacg acgttgattt atttatggac actgtgcttg ttcacggtaa aggcaagaag 1452961 cagcgctata tcccctttgg gtcttatgcc cgcgaagcgt tgaaggtata catgaatagc 1453021 ggaagacagt gcttgctgat gaaggcaaaa gaacctcatg atctattatt cgtaaatcaa 1453081 agaggcggac cgcttacagc ccgtggcatc agacatattt taagcgggct tgttcaaaaa 1453141 gcgtcaagca ctttacatat ccatccgcat atgcttcgac atacgttcgc cacgcatctg 1453201 ttaaatgaag gagcggattt gagaagcgtt caagaactgc tcgggcattc caatctgtct 1453261 tctacacaga tatacacgca cgtttcgaag gaaatgttga gaaacacata tatgtctcac 1453321 catccaagag catttaagaa aaattaaagg aggcccttta tgtcatcttt tcatgcgacc 1453381 acaatatttg ccgtacagca taaaggacga agcgctatgt ccggagacgg ccaagtaaca 1453441 tttggtcagg ctgttgtcat gaaacacacg gcacggaaag tgagaaaact gtttaacggc 1453501 aaagttcttg ctggttttgc gggatctgtt gcagacgctt tcactttatt cgaaaagttt 1453561 gaagctaagc ttgaagaata taacggcaac ttaaaacggg cggctgttga gcttgcaaag 1453621 gaatggcgca gtgataaagt gctaagaaag ctcgaagcca tgctgattgt tatgaatcag 1453681 gatactttgc ttctcgtatc gggaacaggc gaggtgatcg aaccagatga cggcattctc 1453741 gcgattggat caggaggcaa ttacgctttg gcagcgggaa gagcactgaa aaagcatgcc 1453801 ggggaaagca tgtctgcaag tgagattgcc agagccgcgt tagaaacagc aggcgaaatt 1453861 tgtgtttaca cgaacgatca aatcatactg gaagagcttg aatagaaagg acttgaggcg 1453921 catggaaaaa aaaccgttaa ctcctagaca gattgtagat cggttagacc aatatattgt 1453981 cggtcagcaa aatgcgaaaa aagctgtcgc cgtggcatta agaaaccgct atagaagaag 1454041 tcttctggat gaaaagctga aggacgaggt cgttccgaaa aacattttaa tgatgggtcc 1454101 taccggcgtc gggaaaactg aaattgccag acgaatcgct aagctttcag gtgcgccatt 1454161 tatcaaaatt gaagctacta aatttaccga agtcggctat gtaggcagag atgttgaatc 1454221 aatggtcaga gatcttgtgg agacttctgt tcggcttata aaagaagaga aaatgaatga 1454281 agtaaaggaa caggcagaag aaaatgcaaa caaacgcatt gttcgtctgt tagttcctgg 1454341 gaagaaaaaa caatctggtg ttaaaaatcc gtttgaaatg ttttttggag gcagccagcc 1454401 gaatggtgaa gatgaggcgg agagccagga agaagcaaac atcgaagaaa aaagaaaacg 1454461 aatggcgcat cagctggctt taggagagct cgaagactac tatgtaacag tagaagtcga 1454521 agaacagcag ccttctatgt ttgacatgct gcagggctcg ggtatggagc agatgggtat 1454581 gaacatgcag gatgcgctga gcggattaat gccaaagaaa aagaagcggc gcaaaatgac 1454641 agtcagagaa gccagaaaag tcctgacgaa tgaagaagca agcaaactca tcgatatgga 1454701 tgaagtcggc caggaagctg ttcagagagc agaagagagc gggattatct ttatcgatga 1454761 gattgataaa atcgcaaaga acggcggtgc atcttcttct gccgatgttt caagagaagg 1454821 tgttcagcgg gatatccttc cgattgttga aggttctacc gttgtcacaa aatatggttc 1454881 tgtaaaaaca gaccatgtat tatttattgc agcaggagcg tttcatatgg ccaaaccgtc 1454941 tgatttgatt cctgagctgc aggggcgttt cccgattcgt gtagaactga acaaactcac 1455001 ggtagacgac ttcgtgagaa ttttggttga gccggataat gcgctgctga aacaatatca 1455061 ggcattattg cagacagaag gtatatctct tgaattttct gacgaagcta ttcataagat 1455121 tgctgaagtt gcttatcatg tgaaccagga cacagataat atcggtgcga gacgccttca 1455181 tacaatactt gaacgcctat tagaagattt gtcgtttgaa gctccagatg taacgatgga 1455241 gaaaataacg attacaccac agtatgtcga agaaaagctc ggaacgatag ccaaaaacaa 1455301 agatttaagt caatttatat tgtgaaaaat ttaatatgag gaatgtttag gaggattatt 1455361 tatcatggct ttattacaaa aaacaagaat tattaactcc atgctgcaag ctgcggcagg 1455421 gaaaccggta aacttcaagg aaatggcgga gacgctgcgg gatgtaattg attccaatat 1455481 tttcgttgta agccgcagag ggaaactcct tgggtattca attaaccagc aaattgaaaa 1455541 tgatcgtatg aaaaaaatgc ttgaggatcg tcaattccct gaagaatata cgaaaaatct 1455601 gtttaatgtc cctgaaacat cttctaactt ggatattaat agtgaatata ctgctttccc 1455661 tgttgagaac agagacctgt ttcaagctgg tttaacaaca attgtgccga tcatcggagg 1455721 cggggaaaga ttaggaacac ttattctttc gcgtttacaa gatcaattca atgacgatga 1455781 cttaattcta gctgaatacg gcgcaacagt tgtcggaatg gaaatcctaa gagaaaaagc 1455841 agaagaaatt gaagaggaag caagaagcaa agctgtcgta caaatggcta tcagctcgct 1455901 ttcttacagt gagcttgaag caattgagca catttttgag gagcttgacg gaaatgaagg 1455961 tcttcttgtt gcaagtaaaa ttgctgaccg tgtcggcatt acccgttctg ttattgtgaa 1456021 cgcactcaga aagctggaga gcgccggtgt tatcgagtct agatcattag gaatgaaagg 1456081 tacttatatc aaggtactaa acaacaaatt cctaattgaa ttagaaaatc taaaatctca 1456141 ttaatcacaa aaagaaccct ttttgagggt tcttttttta tttcaaataa aggaaatcaa 1456201 taagctttat ttcctgggtt gaaagtcttt ctatgtaata attttaataa attttgcatt 1456261 tttcttcaaa aagtttcaaa aatgccgaaa agaaaggaga aaaaacagaa attctgctat 1456321 tttcaggctt atatcaaggc gagaaatgta gttctaacaa tctaggactt tatacctagt 1456381 tgcaaaatag ataattgtga ggacattttt ttacacgaac ttcatagact ttatgcctgt 1456441 tatttcttac aataagcata tagttttaca attctcgaca aggatattga gggtgaaaaa 1456501 aactgaaatg gaggtaagtg gatttgagct tattttctgg aacgatacaa aatcttgaaa 1456561 atgccttgag cagagcggat attaagcaaa aagtcataac taataatatc gccaatatag 1456621 atacaccgaa ctataaggca aaaaaagtct ctttccaaaa tttattagat caagaatcct 1456681 cgcgtcttga agcgataaaa acagactatc gtcatgttga tttttctgat actgattcga 1456741 attattcaat tgttgcgagc ggagatacat cgtatcagca aaacggaaac aatgttgatg 1456801 ttgacaaaga gatgacagaa ttggcgcaaa atcaaatcaa ctatcaagct ttggttgaaa 1456861 gaatgaacgg taaatttaat tcgctgaaga ccgtattaac aggaggaaaa tgatgacagc 1456921 ttttcatagc ttaaatgttt cagcatcggc tttaacagct cagcgagtca gaatggacgt 1456981 tgtatcatct aacttagcaa atatggatac gacaagagct aagcaggtga atggagagtg 1457041 ggtgccttac agaagaaaaa tggtttccct tcagtcaaaa ggtgaatcgt tctcttccat 1457101 tctcaattct caaatgagcg gaagcgggaa tgctggaaac ggtgtgaagg tttcaaaaat 1457161 tacggaggat gattcggatt ttaatcttgt ctatgatccg acagaccctg atgcaaacgc 1457221 tgaaggatat gtacaaaagc ctaatgttga tccattaaag gaaatggttg atcttgtcag 1457281 cagcactaga tcatacgagg cgaatgtcac ggcgatgaat gccacaaagg gaatgctgat 1457341 gaaggcgtta gaaatcggaa agtaggcgaa ctgttaaaca aggtgaaaaa acgatttaat 1457401 taaggtatta gggggataac aatgcaatcc ttgaattatg aagatcaggt gctttggacg 1457461 cgctggaaag agtggaaaga tcctaaagcc ggtgacgact taatgcgccg ttacatgccg 1457521 cttgtcacat atcatgtagg cagaatttct gtcggactgc cgaaatcagt gcataaagac 1457581 gatcttatga gccttggtat gcttggttta tatgatgccc ttgaaaaatt tgaccccagc 1457641 cgggacttaa aatttgatac ctacgcctcg tttagaattc gcggcgcaat catagacggg 1457701 cttcgtaaag aagattggct gcccagaacc tcgcgcgaaa aaacaaaaaa ggttgaagca 1457761 gcaattgaaa agcttgaaca gcggtatctt cggaatgtat cgcccgcgga aattgcagag 1457821 gaactcggaa tgacggtaca ggatgtcgtg tcaacaatga atgaaggttt ttttgcaaat 1457881 ctgctgtcaa ttgatgaaaa gctccatgat caagatgacg gggaaaacat tcaagtcatg 1457941 atcagagatg acaaaaatgt tccgcctgaa gaaaagatta tgaaggatga actgattgca 1458001 cagcttgcgg aaaaaattca cgaactctct gaaaaagaac agctggttgt cagtttgttc 1458061 tacaaagagg agttgacact gacagaaatc ggacaagtat taaatctttc tacgtcccgc 1458121 atatctcaga tccattcaaa ggcattattt aaattaaaga atctgctgga aaaagtgata 1458181 caataatgaa tttcatggtt agcgagtgaa aaacatgtca acactattat ggcttttaag 1458241 ctttatgctc cacggcgttc ttctgtacgc tgtcattatc ctgtatacga ggctcgctgc 1458301 agtgaaagaa acagaaaaac agcaaaaaca gatacttgaa gagacggaaa acaccttggc 1458361 ggcatttctg cttgaattaa aagaagaaaa tgagaaactg atagaaaata aagcttcatc 1458421 tgcaagtcaa tcagatgaag aatcccaaaa gtcaggcctt cagacctctg aaacatatca 1458481 agagcgggat ccagtccaag aggcagagaa tcttcctgaa catattgaag gtctgattac 1458541 agaggttgac cgtcgggaag agctcgtaaa cagtgaggtc caatcatttg aagaccaggt 1458601 catagaatta tatgaacagg gatattcggc aagtcaaatt gcccagaaaa tgaagagcgg 1458661 aaagacagaa atcgagctat ttttaaaatt tcgctccaaa ggtgtaaagg attcttgatt 1458721 gtcggataaa gctgtgttat attatgtctt ggtgttaaat acacacgctt aacgatttat 1458781 gcagagggtg ctgcaggcgg cagttctgta caaaaatgac ctaagcggag gaaaaaaacc 1458841 attatattag gaggaaataa catgtcagtc atttctatga agcaattgct tgaagctggt 1458901 gttcacttcg gtcaccaaac acgccgttgg aacccaaaaa tgaagcgtta cattttcacg 1458961 gagcgtaacg gaatctacat cattgacctt caaaaaacag tcaaaaaagt agaggaagct 1459021 tacaacttca ctaaaaatct tgctgctgaa ggcggaaaaa tccttttcgt cggaacaaaa 1459081 aaacaagctc aagattctgt taaagaagaa gctcaacgct ctggcatgta ctatgtcaac 1459141 caacgctggt tgggcggtac attaacaaac ttcgaaacaa tccaaaaacg tattaaacgt 1459201 cttaaagaca ttgaaaaaat gcaagaaaac ggtacgtttg atgtacttcc taaaaaagaa 1459261 gtcgttcaat tgaaaaaaga attagagcgt cttgaaaaat tcctaggcgg aattaaagat 1459321 atgaaggatc ttcctgatgc attattcatc atcgatcctc gcaaagagcg catcgctgtt 1459381 gcggaagctc gcaaattaaa catccctatc atcggtatcg tagatactaa ctgtgatcca 1459441 gatgaaatcg atgttgttat cccagcgaac gatgacgcta tccgcgctgt taaacttcta 1459501 acttctaaaa tggcagatgc aatcttagaa gcgaagcaag gcgaagaaga agcggaagtt 1459561 gctgaagaaa ctgcaccaga aacagaaaca acaactgcgt aacctattca aaaggtgata 1459621 agagggactg ccttttatca ccttttttca agaaaaatgt gtaatataca tactcttgtt 1459681 taaacatata aggaggaata caaatggcaa ttactgcaca gcaagtaaaa gaactgcgtg 1459741 aaaaaactgg cgcgggcatg atggattgta aaaaagcgtt aactgaaact gacggagata 1459801 tggacaaagc aattgacctt ttaagagaaa aaggaattgc aaaagcagcg aaaaaagctg 1459861 accgtatcgc agcagaaggt tctactctta ttaaaactga cggcaacaaa ggcgttatcc 1459921 tagaagtaaa ctctgaaact gatttcgttg cgaaaaacga aggttttaaa gagcttctta 1459981 acactttagc tgaccacctt cttgcaaaca cgccagctga tgttgaagaa gcaatgggcc 1460041 aaaaaatgga aaatggctca actgttgaag agtacatcac aagcgcagtt gctaaaatcg 1460101 gtgagaaaat cactcttcgc cgctttacag ttcttacaaa agacgacagc tctgcattcg 1460161 gtgcgtacct tcacatgggc ggccgcatcg gtgtattaac tgttctcaac ggtacaactg 1460221 atgaagaaac tgcgaaagat atcgcaatgc acgttgctgc agttaaccct cgttacattt 1460281 ctcgtgatca agtatctgaa gaagaaacaa atcatgagcg tcaaatctta actcagcaag 1460341 ccctccaaga aggcaaacct gaaaacatcg tagcgaaaat ggttgaaggc cgtctgaaca 1460401 aattcttcga agaaatttgt ctattagacc aagcgttcgt taaaaaccca gatgaaaaag 1460461 tgaaacaagt tattgcagcg aaaaacgcta ctgttcaaac ttttgtccgc tatgaagttg 1460521 gagaaggcat cgaaaaacgt caagaaaact ttgctgaaga agtaatgaac caagtgaaaa 1460581 aataatggtg aaaagatttc gcggctaagt cgcgtctttt caggcagtat aggggacaca 1460641 ttttgtgttc cctattttta aaactatatt tacaaacctt tttttctctt gcataataga 1460701 aaacggcaat gtttacactt ggaggttatc atggaaaaac caaaatacaa acgtatcgta 1460761 ttaaagctta gcggggaagc attggcagga gaacagggaa atggaattaa cccgactgtc 1460821 attcaatcca ttgcaaagca agtgaaggaa atcgctgagc ttgaagtcga agtggctgtt 1460881 gttgtaggcg gcggcaactt atggcgcgga aaaacaggaa gtgacctggg catggaccgc 1460941 gcgactgctg actatatggg aatgctggcg acagtaatga attcgcttgc tcttcaagac 1461001 agcttggaaa cactcggaat ccagtccaga gtgcaaacat ccattgaaat gagacaagtt 1461061 gctgaaccgt acataagaag aaaagcgata cgccacttag agaaaaaacg tgtcgttatt 1461121 ttcgctgcgg gcacaggaaa cccatatttc tcaactgata cgacagctgc actgcgggct 1461181 gctgaaattg aggcagacgt tattttaatg gctaaaaata acgttgacgg tgtgtataat 1461241 gctgatccta gaaaagatga atcagctgtt aagtatgaat cactttctta tcttgacgtt 1461301 cttaaagacg gcctggaagt catggattca acagcttcct ctttatgcat ggacaatgac 1461361 attccgctta tcgtcttttc tattatggaa gaaggaaata tcaaacgtgc cgttatcggt 1461421 gaatcaatcg gaacgatcgt gagggggaaa taacgtgtca aaagaagtat taactcaaac 1461481 aaaagaaaaa atggaaaaag caattgctgc ttatcagcgc gaattggcta ctgtacgcgc 1461541 aggccgtgca aatccatcat tattagataa agtaacggtt gaatattacg gagcgcagac 1461601 acctttaaat cagttgtctt ctattaacgt gcctgaagct cgtatgctcg ttatcacgcc 1461661 atacgataaa acagcaatcg gtgatatcga aaaagcgatt ttaaaagctg atttaggtct 1461721 tacaccaaca agtgacggca atatgattcg aattgcaatt ccggcactaa cagaagagag 1461781 acggaaagaa ttagtgaaag ttgtaaaaaa atatgctgaa gaagcaaaag tagctgttcg 1461841 taacgttcgc cgtgatgcta acgatgatct caaaaaactt gagaaaaacg gagacattac 1461901 tgaggatgaa ctgcgtgctt ccactgaaga cgttcaaaaa ctgacagatg aatatgtgtc 1461961 aaaaattgac agtgtcacaa aagacaaaga aaaagaaatc atggaagttt aatgaaaaac 1462021 tatgtacaat agataatagt gaaaagaccc tctcatgttt acagggggtt tttttgttaa 1462081 tactgttgat tacattgatt atcagcaggg aatgtaacct ttttgggtga cggaggaatc 1462141 tcatgctcaa catactcaaa aattggaaga atcagcaaac tgcggcttcc aacttagaac 1462201 gttatacaaa agaagacata cttaagggag aaattcccga acacatcgcc attatcatgg 1462261 atggaaatgg ccgttgggct aaaaaacgct ctcttcccag aattgcaggc caccatgaag 1462321 ggatgaaggt ggtaaaaagg accacgaagc tcgcaaacga attaggtgtc aaagtactga 1462381 cattgtatgc attttcaaca gaaaactgga aaagaccgaa aatggaggtc gattttttaa 1462441 tgaagcttcc ggaagaattt ttgaatacgt atcttccaga gcttgttgag gaaaatgtac 1462501 aggttcggat cattggggat gaaacggctt tgccggcgca cacattacgt gcgattgaaa 1462561 aagctgtaca ggacacggcg caaaacgacg gaatgatcct taattttgct cttaactatg 1462621 gaggccgtac tgaaattgtc agtgctgcaa aatcactcgc ggaaaaagtg aaggaaggct 1462681 ctttgaatat tgaagacatt gatgaatcgc ttttttctac ttatttgatg actgaatctt 1462741 tgcaggatcc tgaactttta attcgaacga gcggcgagat aaggctgagt aattttatgc 1462801 tatggcaggt tgcctacagt gaatttgtct ttactgacgt cttgtggcct gactttaaag 1462861 aagatcactt cttgcaggcg ttaggagagt ttcagcagag aggccggagg tttggcggaa 1462921 tttagaggat ggtggacatg aaacaaagaa ttttgacagg tgttctggca gcaattgtat 1462981 ttttattttt ggttattgtc gggaaattgc cgttcaccat attaatttat gctatgggca 1463041 gtgtggcgct ttttgaactt ttacggatga aaaagctgaa gctggtttca ctgccgggtt 1463101 tgatcggtct tttattattg tggatgttct tattaccaag ccagtattcg ttttttgaag 1463161 cggacgggat ttccaaaatg gaaatcgctt tatttgcggt actgctattg ctgacttaca 1463221 cagtgttggt caagaacacc tttacttttg atgaagtcgg gtttattacg cttgcagcaa 1463281 tttacatcgg aatgtgtttt cattatttta tcgaaatcag aaatcttgac caatacggat 1463341 taacatacat tttttatgcg tgtgttgtca tttggtccac cgattccggt gcctattttg 1463401 tcggtaaatc gcttgggaag cggaaactgt ggcctgaaat cagtccgaat aaaacagtgg 1463461 aagggtttgc aggcggaatt gtcatcgcac ttgtattggc gacgattttt cagcttgttg 1463521 cacaacttcc gatcccgtat atctatctgc tgttgatcac gctgtttttg tctgtttttg 1463581 gacaactggg agatttagtg gaatccgcct tgaaaagaca ttacgatgta aaggattctg 1463641 ggaatattct tcccgggcat ggcggtatat tagaccgttt tgacagtttc ttgtttgtca 1463701 tgcctttctt gtactttctg cttgcccttt tttcataaaa aagtctaata tgaatatgag 1463761 actgatcatg cagcaataag aataggagta gtggcaactt tgaaaaatat ttgtctttta 1463821 ggagcaacag gatcaatcgg cgaacagact cttgatgtac tgcgtgcaca tcaagaccaa 1463881 tttcagctgg tatctatgtc gtttggcaga aatattgata aggccgttcc aatgattgag 1463941 gtctttcagc cgaagtttgt ctctgtcggt gatctggata catatcataa attaaaacaa 1464001 atgtcttttt cttttgaatg ccaaatcggg ctgggagaag aaggactgat agaagcagca 1464061 gtgatggagg aggttgacat tgttgtcaac gctttgcttg gaagcgtcgg tcttatcccg 1464121 acattaaagg caattgaaca gaaaaaaaca attgcgcttg caaataagga aactcttgtc 1464181 actgcagggc atatagtaaa agaacatgct aagaaatatg atgttccgct gctgcctgtt 1464241 gacagtgagc attcagccat ttttcaagct cttcaaggcg aacaggctaa aaacattgaa 1464301 cgcctcatca ttacggcatc cggcggaagt tttcgggaca agacgcggga ggagctcgaa 1464361 tcagtaacgg ttgaagatgc attaaaacat ccaaactggt caatgggtgc aaaaattaca 1464421 attgattcgg ctacaatgat gaataaggga ttagaggtga tcgaggcaca ctggcttttc 1464481 gatatacctt atgaacaaat tgatgtggtt ttacataagg agagcatcat ccattcaatg 1464541 gttgagttcc atgataaaag tgtgatcgca cagctcggaa ctccggatat gagagtcccc 1464601 attcaatatg cgctcactta tcctgaccga ttgccattac cagatgcgaa aaggcttgaa 1464661 ttatgggaaa tcggcagcct tcattttgag aaagctgatt ttgacaggtt ccgatgctta 1464721 caatttgctt ttgaatcagg taaaatagga ggaacaatgc cgacagtgct aaatgcggca 1464781 aacgaagtag ctgtcgctgc ctttttagct ggcaagatac cgtttttggc tattgaagac 1464841 tgtatcgaaa aggcactaac ccgccatcaa ttactgaaaa aaccgagcct ggcggacatt 1464901 caagaagtgg acaaagatac ccggggatac gtcaattcaa tactcacata aggtggtatg 1464961 ttcgtgaata cagttatagc gtttatcatt attttcggaa cgctcgtttt cttccatgaa 1465021 ctgggccatt tattgctagc ccaaagagcg ggaattctct gccgtgaatt tgcgatcggc 1465081 ttcggtccaa agattttttc tttcaaaaaa aatgaaacag tttatacgat caggctgctt 1465141 ccggtcggcg gatttgttcg tatggccggc gaagatccgg aaatgattga ggtgaaaccc 1465201 ggatacacgg tcgggcttct gtttaataag gaagatcaag ttgagaaagt catcatcaat 1465261 caaaaggaaa aatatccgga tgctttagtc attgaagtgg aaacagcgga tctagagcat 1465321 gacatgaaga tcaccggtta tgaacagggg aaagaggacg aactttccag ctttactgtc 1465381 agcgaaacat ccttttttat tgtagacgga gaagaagtgc agattgcgcc gtataatcgc 1465441 caatttggtt ccaaacctgt atggcagcgg attaaagcaa ttgctgcagg gccgattatg 1465501 aactttattt tagcttacgt cattttagtg atgcttgggc tgattcaagg cgtaccgtca 1465561 aatgaaccta tgctcgggca gctgacagac aatggacggg cggctgaagc agggctaaaa 1465621 gaaggggatt atatccaaag cattaacgga gagaaaatga ggtcttggac tgacattgtc 1465681 tccgctgtaa aagaaaaccc ggagaaagaa atggacgttg cagtaaaaag agataacaaa 1465741 acgcttcata tttcggtgac tccggaagct gttaaagatg agaacaaaaa aacaatcgga 1465801 cgtttcggtt cctatgcgcc gactgaaaaa ggcgtactct cagcggttgc ttacggcgcg 1465861 acatcaacag ttgatgtcac caaagccatt ttaaccaatc tgagcaaatt agtaacaggc 1465921 caatttaaac tcgatatgct gtcaggtcct gtcggcatat atgacatgac agaccaagtg 1465981 gcgaaaacag ggatcgtgaa cttatttcag tttgcggcgt ttttaagcat taaccttggg 1466041 attgtcaacc tgcttccgat tccggcactt gacggaggaa gactgttgtt tctatttatt 1466101 gaagcgattc ggggcaaacc gattaacagg gaaaaagaag catttgttgt gtttatcgga 1466161 gtagctttct taatgcttct tatgctggtt gtcacatgga acgatatcca gcggctgttt 1466221 ttgtaaacga aaagtaaatc aatcagaggt gcgaagaaat gagacaaagc ttgacgctta 1466281 ttcctacgct ccgtgaagtt ccagctgatg ccgaagcaaa aagtcatcag cttcttctga 1466341 gagcaggatt tatcagacag aatacgagcg gggtatacag ctatatgcct cttgcgtata 1466401 aggtgattca aaacattcag cagattgttc gagaggaaat ggagaaaatt gatgccgtag 1466461 aaatgctcat gcccgcattg cagcaggcag agacatggca ggaatcaggc agatggtata 1466521 cgtatggtcc cgaactgatg agactaaaag accgtcatgg ccgtgaattt gctttagggg 1466581 caacgcatga agaggttatc acttcgcttg ttcgcgatga ggttaaatct tataagcgtc 1466641 tccctctgac tctttatcaa attcagtcta agttcagaga tgaaaaacgt cctcgcttcg 1466701 gtttgttaag aggccgcgaa tttattatga aggatgcgta ctctttccat gcatctgcag 1466761 agagcctgga tgaaacgtat caaaaaatgt acgaggccta ttctaatatt tttgcccgct 1466821 gcggcattaa tgtaagacct gttatcgctg attcaggcgc aatgggagga aaggatacgc 1466881 acgaatttat ggcactttct gcgatcggag aggatacgat tgcgtattct gatgaatcac 1466941 agtacgcggc taatatcgag atggctgaag ttcttcacca ggaagttcct tcagatgaag 1467001 agcctaaagc tctagagaag gttcatacgc ctaacgtgaa aacaatcgaa gaactgactg 1467061 cgttcttaca ggtttcggct gaagcgtgca ttaagtcagt attgtttaaa gctgatgacc 1467121 gttttgtctt agtgcttgta agaggggatc atgaagttaa cgatattaaa gtgaaaaact 1467181 tgcttcatgc agaagttgta gagcttgcta cacatgaaga ggtcattcag cagctcggaa 1467241 cagagccagg ctttgtaggc cctgtcggta ttcatcagga tgtggaagta tatgccgatc 1467301 aagctgtgaa agcaatggtt aatgctgttg ccggggcaaa tgaaggagat catcattata 1467361 aaaatgtcaa tgtgaatcgt gacgcgcaaa ttaaagaatt tgctgatctt cgttttatta 1467421 aagaaggtga tccttcacca gacggcaagg gaacgatccg ttttgctgag ggaatcgaag 1467481 tcggacaagt ctttaagctc ggaacacgct attcagaagc gatgaatgcg acatatttag 1467541 atgaaaacgg acgcgcgcag ccaatgctga tgggctgtta cggaatcggt gtgtcaagaa 1467601 cgctttctgc tattgctgaa cagcatcacg acgaaaaagg cttaatatgg ccaaaaagcg 1467661 ttgcgccgta cgatcttcat attcttgctt tgaacatgaa aaacgatggg caaagagagc 1467721 ttgctgaaaa gctgtatgcc gatttaaaag cggaaggcta tgaagtgctc tatgatgacc 1467781 gtgctgagcg tgccggcgta aaattcgctg attcagattt aatcggcctt ccaatccgca 1467841 tcactgtcgg aaaacgagct gacgaaggaa tcgtcgaagt gaaaattcgt caaactggtg 1467901 agtcaactga gatttcagta gacgaattat ctgcgtttat cagcaagcag taatcaccat 1467961 aacgatttat caaaaaacat gttaaaatag aaataataga aggtacctca ttgcctgagg 1468021 taccttcact tatgatgttt ttagggaggg atactgtctt aatggaacag ttatcagtaa 1468081 acagaaggca gtttcaaatt cttctgcagc agattaatat gacagatgat accttcatga 1468141 catactttga acatggcgag attaaaaagc tgacaattca caaagcttct aagtcttggc 1468201 attttcattt tcaatttaaa tctttgctgc cttttcaaat atatgacaca ttaacaacga 1468261 ggctgacgca atcgtttgcc cacatagcaa aagtgacatc ttcaattgaa gttcaggatg 1468321 ccgaggtcag tgaaagtatc gttcaagact actggtcacg ctgcattgaa gaactgcagg 1468381 gcatttcgcc gccgattatc agtcttttaa accagcaaaa accgaagctg aagggcaata 1468441 aactgattgt caaaaccaaa acagatacag aagcggctgc gctaaagaac aaatacagtt 1468501 ccatgattca agcagaatac cgtcaatttg gctttccgga tcttcagctt gatgctgaaa 1468561 tatttgtatc cgagcaagaa gttcaaaagt ttcgggagca aaagcttgcg gaagaccaag 1468621 agcgggctat gcaggccttg attgaaatgg agaagaaaga taaagaaagt gatgaagacc 1468681 aagcaccatc tggtcctctt gttatcggtt atcaaattaa agataacgag gaaatccgaa 1468741 cacttgacag catcatggac gaagaacgga gaattacggt ccaaggttat gtgtttgatg 1468801 tggagacgcg cgagctgaag agcgggcgca cgctgtgtat cttcaaaatt acagactata 1468861 caaatagtat tttgatcaaa atgtttgcac gtgaaaaaga agatgcggcg ctgatgaagt 1468921 ctctgaaaaa aggaatgtgg gtaaaagcac gcggaagcat tcaaaatgat acatttgtca 1468981 gagaccttgt catgatcgca aatgacgtaa acgaaataaa agcaaaaacc cgtgaagatt 1469041 cagcacctga aggagaaaaa agagtggaat tgcatcttca ttccccaatg agccaaatgg 1469101 atgctgttac gggtatcgga aagcttgtcg aacaggcgaa aaaatggggg catgaggcca 1469161 tcgctttgac cgaccatgct gtcgttcaat ccttccctga tgcgtattct gcggccaaaa 1469221 agcatggaat taaaatgatt tacgggatgg aagcgaatct cgtggatgat ggcgtgccaa 1469281 ttgcttataa tgccgcacat cgtctgctcg aagaagaaac atatgttgtt tttgacgttg 1469341 agacgacagg attgtctgct gtatacgata ccattattga gctggctgca gtaaaagtaa 1469401 aaggcggaga aattattgat aaatttgagg cgtttgcgaa cccgcatcgt ccgctttccg 1469461 ccacaatcat agagctgaca gggatcacag atgatatgct acaagacgct ccggatgtcg 1469521 tagatgtaat aagagatttc agagaatgga ttggcgatga tattcttgtc gctcataatg 1469581 caagctttga tatgggattc ttaaatgtag cctataaaaa acttcttgaa gtcgaaaaag 1469641 ctaaaaaccc agtcattgat acgcttgaac ttggacgttt tctctatccg gaatttaaga 1469701 accaccggtt gaacacactt tgtaaaaagt ttgatatcga gctcacacag catcaccgtg 1469761 cgatctatga tactgaggca accgcttatt tgcttctgaa aatgctgaaa gacgcagctg 1469821 aaaaaggtat tcagtaccat gatgagttga atgaaaatat gggtcagtcc aatgcttatc 1469881 aaagatcaag accgtatcat gcaacattac ttgccgtgaa cagcacggga cttaaaaatt 1469941 tatttaagct tgtgtcactt tctcatattc attattttta cagagtgccg cgtattccga 1470001 gatctcagct tgagaaatac agggaagggc ttctgatcgg ttctgcttgt gacaggggag 1470061 aggtttttga gggaatgatg caaaaatcgc ctgaagaggt ggaagatatc gcgtcattct 1470121 atgattacct tgaggttcag ccgcctgaag tgtatcgtca cttgctggag cttgaactgg 1470181 tccgtgatga aaaagcgctg aaagaaatta ttgcgaatat cacgaagctg ggggaaaagc 1470241 ttaataaacc ggttgttgct acgggaaatg ttcattactt gaatgatgag gataaaatct 1470301 acagaaagat tttaatatcc tcacaaggcg gggcaaatcc gctgaatagg catgaactgc 1470361 cgaaagtgca tttcagaacg acagacgaaa tgcttgaagc tttttctttc ttaggtgaag 1470421 aaaaagcgaa ggagatcgta gtcaccaata cccaaaaggt tgcttcttta gttgatgaca 1470481 tcaagccgat taaagatgat ttatatacgc cgaaaatcga aggcgctgat gaagagatca 1470541 gagaaatgag ctatcagcgt gcaagaagca tttacgggga agagctgcct gaaattgtcg 1470601 aagcgcggat tgaaaaagag ttaaagagta ttattggcca cggatttgct gttatttact 1470661 tgatctctca caaacttgta aaacgttcac tagatgacgg gtatctcgtt ggttcccgtg 1470721 gttccgtagg atcttcatta gttgcgacac ttactgagat tactgaggta aacccgctgc 1470781 cgccgcacta tgtttgtcct gagtgccagc attctgagtt ctttaatgac ggttctgtcg 1470841 gttctggttt tgacctgcct gacaagacat gccctcattg cggaacgcct ttgaaaaaag 1470901 acggccatga tattccattt gaaacgttct taggatttaa aggggacaaa gtacctgata 1470961 tcgatttgaa cttctcaggg gaatatcagc cgcaagcaca caattacaca aaagtattgt 1471021 tcggagaaga caatgtatat cgtgcgggaa caataggcac ggtggcagaa aaaacagcct 1471081 acggttatgt aaaaggctat gccggagaca acaatcttca tatgcgcggt gccgaaatag 1471141 atcggctcgt acagggatgc acaggtgtaa aacgtacaac tggacagcac cctggcggta 1471201 ttatcgtagt tccggattat atggatattt atgatttttc accgatccag ttcccggcag 1471261 atgccacagg ttcagagtgg aaaacgactc attttgattt ccactccatc catgacaacc 1471321 tgttaaaact tgatattctc ggacacgatg acccgactgt tattcggatg cttcaagact 1471381 taagcggaat agatccgaaa acaattccga cggatgatcc tgaagtgatg aagatcttcc 1471441 agggaaccga atcactcggt gtgactgaag aacagattgg ctgtaaaacg ggcactcttg 1471501 gaattcctga attcggaacc cgatttgtcc ggcagatgct tgaagataca aagccgacca 1471561 ctttttctga gctcgttcag atttcaggct tgtctcacgg aactgatgta tggcttggca 1471621 atgcacagga gctcatccac aataatattt gtgagctgag tgaggttatc ggctgccgtg 1471681 atgacattat ggtttattta atctatcaag gccttgagcc gtcccttgcc tttaaaatca 1471741 tggaattcgt gcgtaaagga aaaggattaa cgcctgaatg ggaagaagaa atgaaaaata 1471801 acaatgtccc agactggtat attgattcct gtaaaaagat taaatacatg ttcccgaaag 1471861 cccacgccgc ggcatatgtc ttaatggcag tccgcattgc ttactttaaa gtgcatcatg 1471921 ctcttttgta ttatgcggct tattttaccg ttcgtgcaga tgactttgat attgatacaa 1471981 tgatcaaggg ctctacagca atcagagcgg taatggagga tataaacgct aaaggacttg 1472041 atgcttcacc gaaggaaaag aaccttctga ctgttttaga attagcgctt gagatgtgtg 1472101 agagaggcta ttcattccaa aaagtcgatt tatatcgctc cagcgccaca gagtttatta 1472161 ttgacggcaa cagtcttatt ccgccgttta actctattcc agggttaggg acgaacgctg 1472221 ctttgaacat tgtaaaagct cgcgaagaag gcgaattcct ctcaaaagaa gatttgcaaa 1472281 agagagggaa agtatcaaaa acgattttag agtacttaga tcgccatggc tgtctggagt 1472341 cactgcctga tcaaaaccaa ttgtcactgt tctaatatgg aaagcagaat ttctcagaaa 1472401 ttctgcttct atgcatacat aagcgcaaaa agtgccatcg taatattaga gtttctgtca 1472461 cttgcttagg tatgaaggta agcgtatatc catttgcaat aaaaatatgg ttatggtata 1472521 gttttattgg aaatgctaac gattaccgag gcaaagagtg gggaaacccg ctcttttgta 1472581 ttgaacagga gaattttgtc tcgacatgtt catcgtttac tttttagccc ctgctctttt 1472641 gaagcagggt ttttatgcag agtgacgaga cgaatatgag atcgacagca caaggaggaa 1472701 gaacatgagc aaaaaagtga ctgacaccgt tcaagaaatg gctcagccaa tcgtagacag 1472761 ccttcagctg gaactcgttg acattgaatt tgtcaaagag ggccaaagct ggttccttcg 1472821 cgtgtttatt gattccgatg acggtgtgga tattgaggaa tgtgccaaag taagcgaagc 1472881 tttaagcgaa aagcttgatg aggcagaccc aatcagccaa aattactttc ttgaagtctc 1472941 atctccagga gctgagcgtc cgctaaagaa aaaagccgat ttcgaaaaat cactaggaaa 1473001 aaacgtatac attaagacgt atgagcctat tgacggcgta aaagtgtttg aaggtgaact 1473061 ggctgaattt gatggacaaa cagtgacagt tgagatcacg atcaaaacaa gaaagaaacg 1473121 gatcaatatt ccgtatgaaa agatagctaa tgcaagatta gctgttacat tctaatgaat 1473181 acaaatgttt taagggggga gaccgttaaa tgagcagtga attattagat gctctcacga 1473241 ttcttgaaaa agaaaaaggc atcagtaaag aaattatcat cgaagcaatc gaagctgcgt 1473301 taatttctgc ttataagcgg aattttaatc aagcgcaaaa tgtacgggtg gatctaaacc 1473361 gtgaaactgg ctccatccgt gtatttgcaa gaaaagatgt cgttgacgaa gtatacgacc 1473421 agagattaga aatctcaatt gaagaggcac agggcatcca tccggaatat atggtcggcg 1473481 atgtcgtcga aatcgaagtt acacctaagg atttcgggcg catagctgct caaacagcga 1473541 agcaggtcgt cacacagcgt gtgcgcgaag ctgagcgcgg tgtgatttat tctgaattta 1473601 tcgaccgtga agaagacatc atgacaggga tcgtccagcg tctggacaat aaatttatct 1473661 acgtgtcttt aggcaaaata gaagccttgc tgccggttaa tgagcaaatg ccgaatgaaa 1473721 gctacaagcc ccatgaccgc attaaggtat atatcacaaa agtagaaaaa acaacgaagg 1473781 gtccgcagat ttatgtgtca agaacacatc caggcctgtt aaagcgtttg tttgaaattg 1473841 aagtgcctga aatttatgat ggaactgtcg agctaaaatc tgttgccaga gaagccggcg 1473901 accgttcgaa aatttctgtt cgcacagatg atcctgacgt tgatcctgtc ggttcatgcg 1473961 tagggcctaa aggccagcgt gtgcaagcaa tcgtcaatga attaaaaggt gaaaaaattg 1474021 acattgtcaa ctggtccagt gatcctgtag aatttgtcgc gaatgcgctc agcccttcca 1474081 aagtgcttga tgtcattgtt aatgaagaag aaaaagcgac aactgttatt gttcctgatt 1474141 accagctgtc tctggcaatt ggaaaaagag gacaaaacgc acgcttagct gctaaactga 1474201 caggctggaa gattgatatt aagagcgaaa cggacgcaag agaacttgga atctatccga 1474261 gagaacttga agaagatgat gagccgctct ttacggagcc tgaaactgct gaatcggatg 1474321 aataagaggt gactttaggt gaataaacac aaaaagatcc cattacgcaa atgtgtagtg 1474381 actggtgaaa tgaagcctaa aaaggaactg atccgagttg tacggtcgaa agaaggcgaa 1474441 atctcagtag acccgaccgg aaaaaagaat gggcggggtg cttatttaac gctggataaa 1474501 gagtgcatct tagcagcaaa aaagaaaaac actttgcaaa atcaatttca atcacaaatc 1474561 gatgaccaga ttttcgatga attgctggaa ctggcggaaa aggtgaaaaa ataaaatgtc 1474621 tggaatggaa tggtttccct tgctgggtct ggccaatcga gctcgtaagg tcgtgtcagg 1474681 cgaagacttg gtaataaaag aaatcaggaa tgcgcgtgca aagcttgtcc tgcttacaga 1474741 ggatgcatca tctaacacag caaaaaaagt aactgacaag tgcaattatt ataaagtccc 1474801 ttataaaaaa gtcgagagtc gcgcggttct tggacgctct atcggtaaag aagcccgtgt 1474861 cgttgtcgcc gtcactgacc aaggttttgc gaataagctg atcagcttgc tcgattaata 1474921 tttttggggg tgaacgaatg gctaaaatga gagtatacga atatgcaaaa gcgttaaatg 1474981 tttcaagtaa ggaaattttg accgcactga agaacatgga tttagaagtg aataatcaca 1475041 tggccatgct tgaagaaaag gccattaaaa agctagatgc caaatataaa aaaggcggcg 1475101 cagctgctaa atctcaaaag ccagcagaaa cgaacaaaaa caaacagcca caaggggtta 1475161 atcagcaatc agctggaaat caaccaaata aaattcgaga cggaaagaag aatgacgtgc 1475221 agaataatca atttaacaaa aacaagaaga ataacaacaa caaaaaaaat aaacgcaaca 1475281 acaacaataa taaaaaccaa catcagcaaa agcctgtaaa gccgaaaaaa gagcttcctg 1475341 agaaaattac attctctggc actttaacag ttggcgcact tgctgaagag cttggcaaag 1475401 agccttcaga actcattaaa aagctgatgc ttcttggcgt aatggcaacc attaaccaag 1475461 agcttgataa agacacaatc gaactcattg catcagaata tggtgttgaa acagaagagg 1475521 tcattgtgct tgaagaaaca gagctggaaa aatacgaaga gcctgataat gaagaggatc 1475581 ttgaaattcg tcctcctgtc gtgacaatca tgggccacgt tgaccatggg aaaacaacgc 1475641 ttcttgacag catccgtaaa acaaaggttg ttgaagggga agcaggcgga atcactcagc 1475701 atatcggcgc ttatcaaatt gaagagaacg gcaagaaaat cacgttcttg gatacaccgg 1475761 gccacgccgc atttacaaca atgcgcgcac gcggtgcaga agtaactgat attacgattc 1475821 ttgtcgtagc tgccgatgac ggtgtcatgc cgcaaacagt tgaagcgatt aaccatgcaa 1475881 aagcagcaga ggttccaatc atcgttgctg tgaataaaat agataaagaa tccgcaaacc 1475941 ctgaccgtgt aatgcaagaa ctgacggaat acggacttgt ccctgaagct tggggcggag 1476001 aaaccatttt tgtgccgctt tccgctttaa ctggaaaagg cattgatgag ctcgttgaaa 1476061 tgattttgct tgtcagtgag gtagaggaac tgaaagcgaa tccgaatcgt caggcaaaag 1476121 gaacggttat tgaagctgaa ctcgataaag gcagagggtc agtcgcgacg ttgctcgtac 1476181 agactggaac actgcatgtc ggtgatccga tcgtagtcgg caatacattt ggccgtgtcc 1476241 gtgcaatggt caacgacatt ggccgccgtg tgaaaactgc cggcccgtca actccggttg 1476301 aaattaccgg tttgaatgat gtccctcaag cgggagacca attccttgtc tttaaggatg 1476361 aaaaaacagc tcgttctgtc ggtgaagccc gtgcttcgaa acagcttgaa gagcagcgca 1476421 gcgataaagc gaagctcagt cttgatgatt tatttgagca aattaagcaa ggtgatgtaa 1476481 aagacatcaa cctcatcgta aaagctgacg ttcaaggatc tgctgaagct ttaacggctg 1476541 cacttcaaaa aattgaagta gaaggcgtta aagtgaaaat catccataca ggcgttggtg 1476601 cgattactga atcagacatt atcttggcat ctgcttccaa tgcaattgtt atcgggttta 1476661 atgtgagacc ggacggaaat gctaagagta cggctgaagc tgaaaatgta gatattcgac 1476721 ttcaccgtat catttacaaa gtaatcgacg agattgaagc tgccatgaaa ggtatgcttg 1476781 atcctgaata tgaagaaaaa gtaattggtc aagtagaagt acgccaaaca ttcaaagtat 1476841 ctaaaatcgg tacaattgcc ggcggatatg ttactgaagg aaccattacg cgcgacagcg 1476901 gcctccgttt aattcgtgac ggcgtcgtca tctttgaagg cgaagtagat gttctgaaac 1476961 gctttaaaga cgatgtgaaa gaagtttcac aaggctatga atgtggtatt acaattaaga 1477021 aatacaatga cattcgtgaa ggtgacatcc ttgaagcgtt tgtcatgcaa gaaattgaaa 1477081 gaacgtgatc ggatttgcgg agtgtgaatg catcatttat gatgcaggat cgctaaaaga 1477141 aaagcgtgcc gttctgaagc ggattttaac cagggttcaa aacaagttca atgtttcgat 1477201 ttcggagatt ggctatcagg acacctggca aagaaccagc ttcggaatcg ccgctgtttc 1477261 ttcctctcgc gttcaaacag aaaaagaact gcagcgcgtc ctagcgttta tcgattcttt 1477321 tcctgaaatt gaacggacga tcactaggac agagtggttt taacttagag gtgattgaat 1477381 tgagtatgag agcaaaccgt gtcggcgagc aaatgaaaaa agaactcggt gatattatca 1477441 gccgcaagct gaaagacccg agaattggtt ttctgacagt aacggatgta cgtgtatcag 1477501 gtgatttgca aattgcaaag gtgtatatct cggttctcgg tgacgagaaa aaacgggaag 1477561 aagcgctgaa agggctggca aaagcgaaag gatttatccg atccgaaatc ggcagccgca 1477621 tcagacttcg aaaaacgcct gaaattgaat ttgagttcga tgaatcaatc gattacggga 1477681 atcggatcga aacactgatt cacgaattac attcagagaa accatctgaa taaaaaaaga 1477741 gaggataggc gtatatcgtc tgtcctcttt cttcgtttat aagaaaaaaa ctcaaaagaa 1477801 ggagtgaaag gcaaatggtt aacggagttc tccttttaca taaacctgtt ggcatgacat 1477861 cgcacgactg tgtcatgaag atccgaaagc tgttaaaaac aaaaaaagta ggacatacag 1477921 gaacgctcga tccggaagta tcaggcgtgc ttccgatttg tgtaggaaga gcgacaaaaa 1477981 tagtcgaata cttaactgaa aaatctaaaa cgtatgatgc agaaataaca ttgggctttt 1478041 caaccacaac agaggatcaa accggagaaa cggtggaaac aaagcctgtc aatcacgaca 1478101 ttgataaagc ggatgtagaa aaggttttaa acagtttaaa ggggaaacaa gaacaaattc 1478161 cgcccatgta ttccgctgta aaagtaaacg gcaaaaaatt atacgaatac gcaagagcag 1478221 ggattgaagt agaacgtccg aaacgtatga taaccattga agacattgcc ctgacaacag 1478281 agattaaaca tcatggagaa accgcaagct tccggtttac agtgacttgc tccaaaggga 1478341 cctatgtaag gacgctggcg gtcatgatcg gagaaaagct cggatatccg gcccatatgt 1478401 ctcatttaat ccgtacggca tccggagatt tttctctcga cgaatgcttt acttttgatg 1478461 aactcgaagc acaggcccaa tccggaaccg tggaagagca tacagttcct attgaacgtg 1478521 cgctcaatca tttgccgaaa tggatcataa gtgatacatt agctaagaaa gtagaaaatg 1478581 gggctttgct tgagacgccc gagcagtttt ctgaaatgac aagtggagac cgtattgccg 1478641 tctttactga atccggaacc tgcttggcga tctatttccc tcatcctgca aaaaaagggc 1478701 tgttaaagcc ggcaaaagta ttgatgcaaa aaagcgaaca atagaaaaaa ggtgaccgtt 1478761 ctgtgaagac gatacatatt acacatcctc atcatttaat aaaagaggag caggcaaaat 1478821 cagtgatggc gttaggttat tttgacggcg ttcatctcgg gcatcaaaag gtaatcggca 1478881 cagcgaagca aatagccgaa gaaaaaggtc tgacattagc tgtgatgacc tttcatcccc 1478941 atccttctca cgtgttgggc agagataagg aaccaaagga tctgattacg cctcttgaag 1479001 acaaaataaa ccaaattgaa caattaggca cagaagttct gtatgtcgtt aaatttaatg 1479061 aagtgtttgc ttctctttct cctaagcagt ttatagacca gtatattatc ggccttaatg 1479121 tgcagcacgc agtggcaggc tttgacttta cgtacggcaa atacggcaag ggaacaatga 1479181 agaccatgcc ggatgattta gacggaaaag ctgggtgcac aatggtagaa aaattaacgg 1479241 agcaggataa aaaaatcagt tcttcgtata tccgtaccgc gcttcaaaac ggagatgttg 1479301 aattggcgaa tgtcttgctt ggacaacctt attttattaa aggaattgtc attcatggtg 1479361 ataaaagagg gcggaccatc gggtttccga cagcgaatgt cggtttaaat aacagctata 1479421 tcgttccgcc cacaggtgta tatgccgtaa aagcggaagt gaacggcgaa gtttacaatg 1479481 gcgtttgcaa tattggctat aagccaacgt tttatgaaaa gcgccctgaa cagccttcca 1479541 tcgaggtcaa tctgtttgat ttcaatcaag aggtatatgg agccgctata aaaatcgaat 1479601 ggtacaaacg gattcggagc gagcggaaat tcaatggcat caaagaatta actgagcaaa 1479661 ttgagaaaga taagcaggaa gccatccgtt atttcagcaa tttgcggaaa taacttgcaa 1479721 cgcacgcaaa ttttattcta aaatatttgc atataggcac gatttttagt atgatagttt 1479781 tcgtagtctt aaaaccattg cttggcaatc cgaagtcacc gacggttgct aggtaactgg 1479841 ggctaaatat gatttggagg tgaaacagga tggcaattac tcaagagcgt aaaaaccaac 1479901 tcatcaatga gttcaaaaca cacgaatctg atactggatc tccagaagtt cagatcgcta 1479961 tcctaactga ctcaattaac aacttgaacg agcatttacg tactcacaag aaagaccacc 1480021 actcacgtcg cggtcttctt aaaatggtag gtaagcgtcg taatcttctt acgtatctgc 1480081 gtaataaaga cgtaactcgt taccgtgagt taattaacaa actaggctta cgtcgataat 1480141 cgtaaaaagc gggaggattc ccgctttttt atcgtattaa agcgaaattt cttataacaa 1480201 atcattgaaa tccttttaca tactactttg acattgatat gttcaattca tttcgttcat 1480261 aataggagta attgattatt tcacacaacg aagagaggag ttcgtaattg tatgggacaa 1480321 gaaaaacatg tctttaccat agattgggcc ggaagaacgc ttaccgttga aaccggccag 1480381 cttgccaaac aggcaaatgg tgctgtgatg atccgctacg gtgatacagc agtacttagt 1480441 acagcaaccg cttcaaaaga acctaaaccg cttgatttct tccctcttac tgtaaactat 1480501 gaagaaagat tatatgcggt agggaaaatt ccgggcggat ttattaaaag agaaggacgt 1480561 ccaagtgaaa aagcggttct tgccagccgt ttaattgacc gtccgatccg tcctttgttt 1480621 gccgatggat tccgtaatga agttcaagtc atcagcattg tcatgagtgt tgaccaaaac 1480681 tgctcttcag aaatggctgc catgttcggt tcatctcttg cactttctgt atcggatatt 1480741 ccgtttgaag gaccgattgc aggggttact gtcggacgca ttgatgatca atttatcatt 1480801 aacccgacag tcgatcagct tgaaaaaagc gatatcaatc ttgtcgttgc cggcacgaaa 1480861 gatgcgatta acatggtaga agcgggagcg gacgaagttc ctgaggaaat catgcttgag 1480921 gccattatgt tcggccatga agagattaaa cgcctgattg cattccaaga agaaattgtt 1480981 gcagcagtcg gcaaagagaa atctgaaatt aagctctttg aaattgatga agagcttaat 1481041 gaaaaagtaa aagctttggc agaagaggat ctgctgaaag ccatccaagt tcatgaaaag 1481101 catgcccgtg aagatgccat taacgaagtg aagaacgcag ttgtggcaaa attcgaggat 1481161 gaagaacatg atgaagacac aatcaagcaa gtgaagcaga ttttatccaa gcttgtgaaa 1481221 aatgaagttc gccgcctgat tactgaagag aaagtaagac cggacggccg cggtgtcgat 1481281 caaatccgtc cgctctcttc agaggttggc ctcttgccaa gaacgcacgg ttcaggtcta 1481341 tttacaaggg gacaaactca ggccctcagc gtatgtacgc taggtgctct gggagatgtg 1481401 caaatccttg acggcttagg tgtcgaagag tcgaaacggt ttatgcatca ttacaacttc 1481461 ccgcaattca gcgttgggga aacaggaccg atgcgcggac cgggacgtcg tgaaatcgga 1481521 cacggagcac tgggtgagcg tgcgcttgag ccagttattc cgtctgaaaa agacttccct 1481581 tatactgtcc gtcttgtttc agaagtgctt gaatcaaacg gttctacatc tcaagcaagc 1481641 atttgcgcaa gcacacttgc aatgatggat gccggtgtac cgattaaagc gccagttgct 1481701 ggtattgcga tgggtcttgt caaatcaggc gaacattaca ctgtcttgac tgacatccaa 1481761 ggcatggaag acgcgctcgg agatatggac tttaaagtag cgggaactga aaaaggcgta 1481821 acggccctgc aaatggacat taaaattgaa ggcctttcca gagagattct tgaagaagcg 1481881 cttcagcagg cgaaaaaggg cagaatggaa atcctcaaca gcatgcttgc aacattaagc 1481941 gaatcaagaa aagagctttc tcgatatgcg cctaagatct taacaatgac cattaatcct 1482001 gataaaatcc gcgatgtcat cggaccaagc gggaaacaaa tcaataagat catcgaagaa 1482061 accggtgtta aaattgatat tgagcaggac ggcacaatct ttatttcctc tacagatgaa 1482121 agcggcaacc aaaaagcgaa aaaaatcatc gaagaccttg tgagagaggt tgaagtcggc 1482181 caactttacc taggtaaagt gaaacggatt gaaaaattcg gggctttcgt tgaaattttc 1482241 agcggaaaag acggtttggt gcacatttca gagcttgcgc ttgaacgcgt agggaaagtt 1482301 gaagatgttg tgaaaatcgg agacgagatt cttgtcaaag tcactgaaat tgataaacaa 1482361 ggacgagtga atttatcccg caaagcggtg ctccgtgaag agaaagaaaa agaagaacaa 1482421 caatcttaaa tgaaaacata aaaggagcct gggagacccg gcttctttat tttgaagctt 1482481 ttcaaaagca ggcgggttct accttgtcct tctccttcat aatgtgaggt gaggggggga 1482541 cagaacatgt acaaaaaatt tgtaccgttt gccgtttttt tatttctttt ttttgtctca 1482601 tttgagatga tggaaaatcc gcatgcactt gattatatag gggcaatgaa aaaagatacg 1482661 gtgactgtca cggcgtcaaa agacccgtta tatgaagaat tgcttcaaaa agcgccggag 1482721 tacgaagtta agccccagaa tgcaagaatt gataaagtgt ggaaaagcat tccaggctac 1482781 aatggattaa aggtcaatat tgaacaatca tataaaaaaa tgaaacagca tggtaagttt 1482841 cgggaaaaag atttggtgta cagtcaagta aaaccaagtg ttcatcttga gtcacttcag 1482901 cctgagccta tttataaagg aaatcctgac aaaccgatgg tggctttttt aatcaatgtg 1482961 gcatggggaa atgagtattt ggaaaaaatg cttcctattc tgcaaaagca ccaggttaaa 1483021 gctacgttct ttttagaagg caattgggtg agaaacaatg tacagctcgc taagaagatt 1483081 gcaaaagacg gacatgaaat cggaaatcat tcatacaatc atccggatat gagcaaactg 1483141 actacaggaa gaatttccga gcagctcgac aagactaatg aacaaataga acaaacgatc 1483201 ggcgttaagc caaagtggtt cgctccgcca agcggaagtt tcagaaaagc ggttatcgac 1483261 attgcagcag agaaacagat gggaacagtc atgtggacag ttgatacaat cgattggcaa 1483321 aagccggctc cgtctgtact tcagacgaga gtgttaagca agatacataa tggtgccatg 1483381 attttaatgc atccgactga ccctacggcg gaaagtcttg aagcgctgat tacacagata 1483441 aaagacaaag gatatgcgct tggaacagtc actgaactaa tggatgaaac aagactattg 1483501 aagtaacaga tgaaggcagc ttgtctttga ataggaggaa caaatttgat taaacgatat 1483561 acgtgtcaaa atggtgtaag aattgtgctg gaaaataacc cgacagtccg ttctgttgcg 1483621 atcggcgtat ggatcggcac aggttcgaga catgaaacgc cggagataaa cggaatttct 1483681 cactttttag agcacatgtt ctttaaaggg acgagcacaa aatctgcacg cgagatagca 1483741 gaatcttttg atcgtattgg cggccaggtc aatgcgttta cttcaaagga atatacctgc 1483801 tactatgcaa aggtgcttga cgagcatgcg aattacgcgc tggacgtatt agcagatatg 1483861 ttctttcatt caacgtttga tgaaaacgag ctgaaaaaag agaaaaatgt agtatatgaa 1483921 gaaattaaaa tgtatgaaga tgcgccggac gacattgtac atgatttatt gagcaaagcc 1483981 acttacggca atcattcttt aggctaccca attttaggaa cggaagaaac gcttgcttcc 1484041 tttaacggtg actctctcag acaatacatg catgattatt atacgccgga ccgagtggtg 1484101 atttcggtag cgggcaatat atctgacagt tttatcaaag atgtagaaaa atggttcggg 1484161 tcatacgagg cgaaaggcaa agcgacaggc cttgagaagc ctgagttcca cacggaaaaa 1484221 ctgacgagaa aaaaagaaac agagcaggct catttgtgcc ttggatttaa aggcttagag 1484281 gttggccatg aacgtattta tgatttaatc gtcctcaaca atgtgctcgg aggcagcatg 1484341 agcagccggc tgttccaaga tgtgcgtgaa gataaaggac ttgcttattc tgtttacagc 1484401 tatcacagct catatgagga cagcggaatg ctaacgattt acggcggaac gggtgcaaat 1484461 cagcttcagc agctgtcgga aacaattcaa gaaaccctgg ccacattaaa acgtgacggc 1484521 attacctcga aagaactgga aaacagcaaa gagcaaatga agggaagctt aatgctgagc 1484581 ttagaaagca caaacagcaa aatgagccga aacggaaaaa atgaactgct gctcggcaaa 1484641 cataaaacat tagatgaaat tatcaatgaa ttaaacgccg tgaacttaga gcgtgttaat 1484701 ggccttgcca gacaattgtt taccgaagac tatgcattag cacttatcag cccttccggc 1484761 aatatgccgt cttaaaaagg aaagcctgcc ccataatgga gcaggcattt tttaatccct 1484821 ttcatcatac atagtacaag ggggtgacag acatgcggct cagtgaatta tcgggaaagg 1484881 aaattgtaga catcaaaaga gctgaacggc tcggagtgct cggccagacc gatttggaaa 1484941 tcaatgaaca ggatggacag attacagcac tcctcattcc cacagttaag tggtttggtt 1485001 tgagaaagca aggtcatgac attcgtgtcc catggcacca tattcaaaag atcggttcag 1485061 atatgattat attagatgta cctgaggaaa tgcctcctcg acaagagtaa atagcccaat 1485121 tgactgtgaa gcgggctcta aagaaaacat ctgaaacatc ggctgccgga gccgatgttt 1485181 ttttatatgg aaaaagcgca tcttttatat tcaccggtat ttccttttga tcataagatg 1485241 aaggggagct taacaactag agatccagta tatacaaaga aggtgaacgt ttagaatgtt 1485301 aaccggattg aaaattgcag ttatcggcgg tgacgcaaga cagctcgaaa ttataagaaa 1485361 gctcactgaa cagcaggctg acatctatct tgtcggtttt gaccaattgg atcacggttt 1485421 taccggggca gtaaaatgca atattgatga aattcctttt cagcaaatag acagcatcat 1485481 tcttccagta tccgcgacaa caggagaagg tgtcgtatcg actgtatttt cgaatgaaga 1485541 agttgtgtta aaacaggacc atcttgacag aacgcctgca cattgtgtca ttttctcagg 1485601 aatttctaac gcctatttag aaaacattgc agctcaggca aaaagaaaac ttgttaagct 1485661 gtttgagcgg gatgacattg cgatatacaa ctctattccg acagtagaag gaacgatcat 1485721 gctggctatt cagcacacgg attatacgat acacggatca caggtggccg ttctcggtct 1485781 ggggcgcacc gggatgacga ttgcccgtac atttgccgcg ctcggggcga atgtaaaagt 1485841 gggggcaaga agttcagcgc atctggcacg tatcactgaa atggggctcg ttccttttca 1485901 taccgatgag ctgaaagagc atgtaaaaga tatagatatt tgcattaata ccataccgag 1485961 tatgatttta aatcaaacgg tactttctag catgacacca aaaaccttaa tattggatct 1486021 ggcctcacgt cccgggggaa cggattttaa atatgccgag aaacaaggga ttaaagcact 1486081 tcttgctccc gggcttccag ggattgtcgc tcctaaaaca gctgggcaaa tccttgcaaa 1486141 cgtcttgagc aagcttttgg ctgaaataca agctgaggag gggaaataag gatgtcgtca 1486201 ttaaaaggaa aaagaatcgg gtttgggctg accgggtcgc attgcacata tgaagcggtt 1486261 ttcccgcaaa ttgaggagtt ggtcaacgaa ggagctgaag tccgtccggt tgtcacattt 1486321 aatgtaaaat ctacaaatac ccgatttgga gagggcgcag aatgggttaa aaaaattgaa 1486381 gacctgactg gatatgaggc cattgattcg attgtaaagg cagaacctct tgggccgaag 1486441 ctgccccttg actgcatggt cattgcgcct ttaacaggca attcaatgag caagctggca 1486501 aatgccatga cggacagccc ggtgctgatg gcggcaaaag cgacaatccg gaacaatcgg 1486561 cctgtcgttc tgggtatctc gacaaatgat gctcttggtt taaacggaac aaatttaatg 1486621 aggctcatgt caacaaaaaa tatctttttt attccattcg ggcaagatga tccatttaaa 1486681 aaaccgaatt caatggtagc caaaatggat ctgcttccgc aaacgattga aaaggcactc 1486741 atgcaccagc agcttcagcc gattctagtt gagaattatc agggaaatga ctaaatttac 1486801 agaaaatctt tcccaaacta aaaaattcgg tcatcacccg catattctat ggtaaaataa 1486861 aacgtaaaat catagtcaaa tcaattcaat gaagctgatt ggcggaagga gttttacaga 1486921 tgggaagagg tttacacgta gctgttgtcg gagcgacagg ggctgtggga caacaaatgc 1486981 ttaaaacact tgaagacaga aactttgaaa tggacacact tacattgcta tcttcaaaac 1487041 gctctgcggg gacaaaagtc acgtttaaag gccaagagct gactgttcag gaagcttctc 1487101 ctgagagctt tgaaggggta aatattgctt tgttcagcgc cggcggaagc gtatcacaag 1487161 cattggcacc agaagctgta aaacgcggcg ctattgttat agataatacg agtgcgttcc 1487221 gcatggatga aaatacaccg cttgttgtgc cagaagtgaa tgaggcagac ttgcatgaac 1487281 acaacggcat tattgccaat ccaaactgct ctacaatcca aatggttgcg gcacttgaac 1487341 cgatccgcaa agcatatggc ttaaacaagg tcatcgtatc aacttaccag gcagtatcag 1487401 gagcgggtaa tgaagctgta aaagagcttt acagccaaac acaggcgatt ttaaataaag 1487461 aagaaataga gcctgagatc atgcctgtaa aaggtgacaa aaaacactat caaatcgcct 1487521 tcaacgcgat tccgcaaatc gataaattcc aagataacgg ctatacgttt gaggaaatga 1487581 aaatgataaa tgaaacgaaa aaaatcatgc acatgcctga ccttcaagta gcggctacat 1487641 gtgtgagact gccaatccaa actgggcact cagagtccgt ctacatcgaa atagaccgtg 1487701 atgacgctac agttgaagat attaaaaatc tattgaaaga agctccgggc gtgacacttc 1487761 aggatgatcc aagccagcag ctttatccga tgcctgctga tgctgtcggc aaaaacgatg 1487821 tgtttgtagg ccgcatccgc aaagacttgg acagagcaaa cggttttcat ttatgggttg 1487881 tttctgataa cctattaaaa ggcgcggcat ggaactctgt tcaaattgca gaaagcctga 1487941 aaaaactaaa cctcgtataa aagagagaat tttctaaaga cgaatagaag agagtaaggc 1488001 gctatcagcc tgctctcttc tgttacgtcc gaataatttg gagtgaaaac agtgaagata 1488061 attgttcaaa agttcggcgg aacatcagta aaagatgata aaggccgcaa actggcttta 1488121 gggcatatta aagaagcaat cagtgaagga tataaggttg tcgttgtcgt ttcagcgatg 1488181 ggccgaaaag gggacccgta tgcaacagat tctttgctcg ggctgcttta cggcgatcag 1488241 tcagcgattt ctcctaggga gcaggatttg cttttatctt gcggagagac tatttcctct 1488301 gtcgtcttta caagcatgct gcttgataac ggtgtgaaag cagctgcgct gacaggggct 1488361 caggctggct ttttaacgaa tgatcagcat actaatgcga aaatcattga aatgaaaccg 1488421 gagcgtttat tcagtgtgct cgccaatcat gatgcggtag tcgtcgcagg cttccagggc 1488481 gcaactgaaa agggtgatac aacaacaatc ggcagagggg gcagcgatac gtctgcagcc 1488541 gcactcggag cagctgttga tgcggaatac atcgatattt tcaccgatgt agaaggcgtg 1488601 atgactgctg acccaagagt ggtagaaaat gcaaaaccgc ttcctgttgt gacgtatacg 1488661 gaaatctgca acctggcgta tcagggggcc aaggtcattt ctccgcgtgc tgtggaaatc 1488721 gcaatgcagg ccaaggttcc gatccgcgtc cgttcgactt attcgaatga taaaggcaca 1488781 ttggtgacat cacatcactc ttccaaggtc ggcagtgatg tttttgaaag gctgattacg 1488841 ggaatcgccc atgtcaaaga tgtcacgcag ttcaaagtgc ctgcgaaaat cggccagtat 1488901 aacgttcaga ctgaagtgtt caaggctatg gcaaacgctg gaatcagtgt cgatttcttt 1488961 aacattacac ctagtgaaat cgtctatacg gtagccggaa ataaaacaga aacagctcag 1489021 cgtattttaa tggatatggg ctatgatcca atggtgacga gaaactgcgc gaaggtatcg 1489081 gcggtcggcg cgggcattat gggtgttccc ggtgttacgt ccaaaattgt atcggctctt 1489141 tcagaaaaag aaattccgat ccttcagtcg gctgacagcc atacgacgat atgggtgctc 1489201 gtccatgaag cggatatggt tcctgctgta aacgctttgc atgaagtgtt tgaactttcg 1489261 aagtaaatgt gattgaatca tgatgaggtg aataaaatga atttcggaaa tgtgtctaca 1489321 gcgatgatta caccctttga caataaaggg aacgtagact ttcaaaaact gtctacactg 1489381 attgattact tgttgaaaaa cggaacggat tctttagtag tagcgggaac aactggagaa 1489441 tctccgaccc tttcaactga agaaaaaatt gcgctttttg aatatacggt aaaagaagta 1489501 aacggacggg tgcccgttat cgctggtact gggagcaaca acacgaaaga ttccattaag 1489561 ctgacaaaaa aagctgagga agcgggcgtg gacgctgtta tgcttgttac cccgtattac 1489621 aataaacctt ctcaagaagg aatgtaccag cattttaaag caattgcggc agagacatct 1489681 cttccggtta tgctctataa tgttcctggc cgtacggttg cttctcttgc tcctgaaacg 1489741 acgatccgtt tggcggcaga cattccgaat gtggttgcga ttaaagaagc gagcggagac 1489801 ctcgaagcga ttacaaaaat tattgctgaa acacctgaag acttctatgt ctattcaggg 1489861 gatgatgctc taacgcttcc aattctttca gttggaggta gaggagttgt gtcagtggcg 1489921 agccatattg caggcactga tatgcagcaa atgatcaaaa attatacgaa tgggcaaaca 1489981 gctaatgcgg cactgattca tcagaaactg ctgccgatta tgaaggaact gtttaaagcg 1490041 cctaatcctg ctccagtcaa aacagcgctt cagctgagag gtcttgatgt cggttctgtg 1490101 cgtctgcctc tagtcccatt aactgaggat gaacgtctga gcttaagcag cacgatcagc 1490161 gaactgtaag aaaatttcat acagtgaaac aaacgcggtc attctcacat tcagctgagt 1490221 ttgaccgttt cttttacata ttggttttcc ctaaaccttc tgctttatct tgttttctaa 1490281 atttactttc agttataata ggaacaagtg atgatggacg ggtatgagac taggaggata 1490341 tagattttga aaaagaaaaa tacagaaaac gttagaatta tcgcccttgg cggtgtcgga 1490401 gagattggga agaaccttta tgtcattgaa attgactcag acatatttgt cgttgatgcc 1490461 ggccttatgc atccagaaaa cgaaatgctc ggtattgatg tagtgattcc tgacatatca 1490521 tatttgattg aacgggctga ccgcgtcaag gcaatctttt taacgcacgg gcacgatgaa 1490581 aatatcggcg gcgtttttta cttattaaac aagctgtccg ttccagtgta cggaacaaaa 1490641 ctgacgcttg cactgttaag agagaaatta aaacaatacg gacataaccg aaaaactgat 1490701 ttaagagaaa ttcactccaa atctgtcatt acatttgaat caacaaaggt atcgttcttt 1490761 agaacgattc acagcattcc tgattctgta ggtgtgagct ttaaaacatc acttggatct 1490821 attgtatgca cgggagactt caaatttgac caaacacctg cacttaatca gacgtgcgac 1490881 attggcgaga tcgccaagat cggcaatagc ggcgtgctcg ctctgctttc tgacagtgca 1490941 aatgcggaac ggccgggtta caccccttcg gaagcggctg tcagcggaga aatttcggat 1491001 gcgctgtata attcacagaa ccgggtgatt attgctgttt tcgcatccaa tattaaccgg 1491061 attcagcaag tcattcatgc agcggctcaa aatggcagaa agattgccgt agccggaaaa 1491121 aatcttcaat ctgtcctgca gctggcgaga aagttaggat atattgaagc agatgatgaa 1491181 ttgtttattt ctgtacagga tgtcaaaaaa tatccgaagc gcgaagtggc cattattaca 1491241 gccggaagcc aaggtgaacc attagctgct ttgacaagaa tggcaaacaa agctcacaaa 1491301 cagctgaaca ttgaagaagg ggatacggtg gtcattgcgt caactccgat tcccgggcag 1491361 gaactcattt actctaaaac agtagatctt cttgcgagag ccggtgcaca agtcatcttt 1491421 gcccaaaagc gtgttcatgt atcaggccac ggctcacaag aagagttaaa gctgatgatc 1491481 aacctgctta aaccaaaata tttgattcct gtaaacggcg aatacagaat gcaaaaagct 1491541 cattcaaaaa tcgctgaaga aaccggcatg aagcgcagtg acatcttctt aattgaaaaa 1491601 ggcgacgtcg ttgaattccg cggccaaaac gtaaaaattg gggataaagt tccttacggc 1491661 aatattttaa ttgatggttt aggtgtcggt gatatcggca atatcgtatt gagagaccgc 1491721 cgcttgcttt cacaggacgg aattttaatc gttgtcatta cacttgataa acaaaagaaa 1491781 catcttgtat caggaccaga aattatcact cgcggctttg tttatgtaag agagtctgaa 1491841 ggtcttatcg tacaggctac tgagcttgta cggtccatcg tgacagaagc gactgaaaca 1491901 tcaaatgtcg aatggtcaac gctgaagcag gcaatgcggg atgctttgaa ccaattcctt 1491961 tatgaaaaaa cgaaacgtaa accgatgatc atcccaatta ttatggaagt ataatgactg 1492021 actaaagacc ggagctgctc cggtctttat tttttgtcct tcaagccggg attgaatgaa 1492081 gtatctttgt tcataataca aagagaaact cggaaaggat gaaagcgaga tggatcatcg 1492141 tatggaaaac acagaagaag agcgtcctga aaaaaatgat gcgaaggaca gcattatgaa 1492201 taaaatacag cagcttggtg aaacgacgct tccgcagctg ccccaagata caaatattca 1492261 ttgtctgacc attatcggac aaattgaagg ccatgttcag cttcctccgc aaaacaaaac 1492321 aacaaaatat gaacatgtca tcccgcagat tgtggcaatt gaacaaaatc ccaaaattga 1492381 aggcttgctg atcatattaa atactgtcgg aggagatgtt gaagctggtc ttgccatagc 1492441 ggaaatgctt gcatctttat cgaaaccgac cgtttctatc gtgcttggcg gggggcattc 1492501 aatcggcgtt ccgattgctg tatcctgtga ttacagctat atcgccgaaa cagcaacgat 1492561 gacgattcat ccagttaggc tcaccgggct ggtcatcggg gtgccgcaaa cgtttgaata 1492621 cctggataag atgcaagaaa gagttgttaa atttgtgaca agccattcca atataaccga 1492681 agagaagttt aaagagctaa tgttttcaaa aggaaactta acacgcgata tcggaacaaa 1492741 tgtagtcggt aaggatgcag ttaaatacgg attgatcgat cacgcaggcg gtgtcggaca 1492801 ggcaatcaat aaactgaatg agctcatcga tgaagcaagg aaagaagaag gacggatgat 1492861 tcaatgattc tttataccgt gatgcctcag gaaattgtgt ttgcagaaca gaaccaagag 1492921 acaagcgcac atgagcaaat tgaatataaa ggtgtaccgc ttctagtcga aatgaaaggg 1492981 aatgaagcgg aagtcattca aatcatgagc accaatccaa tgcattttct gcatccggac 1493041 atttcaccgg gacaaaagct gaaattaaac gtataagaat ccaacccttt tttaagggca 1493101 aaatatgcta taatagggga atcctacaga aaaaacgcag cctgtaaacg gctgctttct 1493161 tcattatgta tgaacttaca ttttttaacg cagtaaggtg atgagtgtgg caaagaaaaa 1493221 acgaaaatca agaaaaaaac aggcgaaaca gctcaatata aaatacgagc tcaacggatt 1493281 gctgtgtata gccatttcaa ttatcgcaat cttgcagctg ggggtagtcg ggcaaacgtt 1493341 tatctatttg ttccgctttt ttgctggaga gtggtttatt ttatgcttgt taggtttatt 1493401 ggtgttagga gtctcactgt tttggaagaa aaaaacccca agccttttaa cgagacgaaa 1493461 ggccgggttg tactgtatta tcgcaagcat attgctgctt tctcacgtgc agctatttaa 1493521 aaatttgacg cacaaagggt ctattgagtc tgcaagcgtg gtgcgcaata cgtgggaatt 1493581 gtttttaatg gacatgaatg gcagctctgc ttcacctgat ttaggcggag ggatgatcgg 1493641 tgcgctgctg tttgcggctt cacacttttt gtttgcgtcg actggttctc agatcatggc 1493701 aattgtcatg attttgatcg gaatgatttt agtaacagga cgctcgctgc aagaaacgct 1493761 aaaaaagtgg atgagcccga ttggacgttt tataaaagaa caatggttag catttattga 1493821 tgacatgaaa tccttcaaat caaatatgca gtcatcgaaa aaaacgaaag cgccgagcaa 1493881 aaaacaaaaa ccggcccgca aaaaacagca aatggaaccg gagcctcctg atgaagaggg 1493941 ggattatgaa acagtatcgc ctcttattca ttcagagccg attatctcaa gcttttctga 1494001 tcgtaatgaa gaggaagagt ctccagttat agaaaagcgc gccgaacctg tgtcgaagcc 1494061 gcttcaggac atccaaccgg agacaggtga tcaggaaact gtttctgctc ctcctatgac 1494121 ctttacagag ctcgaaaata aggattacga gatgccgtca ctggatttgc tggcagatcc 1494181 gaagcatacc ggccagcagg ctgataaaaa gaatatttat gaaaatgcga gaaagcttga 1494241 acgcacattc caaagctttg gcgtaaaggc gaaagtcaca caggttcatc tcggaccggc 1494301 cgtaacaaaa tatgaagtat atcctgatgt cggagtgaag gttagcaaaa ttgtcaattt 1494361 aagcgatgat ttagcgcttg cgcttgctgc gaaggatatc aggatcgaag cgcctatacc 1494421 aggcaaatca gcaatcggaa ttgaagttcc aaacgcagaa gtggcaatgg tttcgctgaa 1494481 agaagtgctg gagtctaaat tgaatgacag accggatgcg aagctgttaa ttggactcgg 1494541 ccgcaatatt tcaggtgaag ctgtattggc tgagttaaac aagatgcccc accttttggt 1494601 cgcaggcgca accggtagcg ggaaaagtgt ctgtgtcaac ggcattatta caagtatttt 1494661 aatgcgggcg aaaccgcatg aagtgaaaat gatgatgatc gatcctaaaa tggtagagct 1494721 aaatgtctac aacgggattc cgcatttgct tgctcctgtt gtaaccgatc cgaaaaaagc 1494781 gtcgcaggct ttgaaaaagg ttgtcaatga aatggagcgg cggtacgaat tattttctca 1494841 tacgggtaca agaaatattg aaggatacaa tgattatata aaacgcgcca acaatgaaga 1494901 aggagcgaaa cagccagagc tgccttatat tgttgtcatt gtggacgagc tagccgatct 1494961 catgatggtc gcttcatctg atgtggaaga ttcgattacg agattgtccc aaatggcgcg 1495021 ggctgccggc atccatctta ttattgcgac acagcggcca tcggtggatg ttatcacagg 1495081 ggtgatcaaa gcgaacattc cgtcacgaat cgcgttcagc gtatcttcac agacggattc 1495141 aaggaccatt cttgacatgg gtggcgctga gaagcttctt ggccgcggcg atatgctgtt 1495201 tttacctgta ggggctaaca aacctgtccg tgtgcaggga gcatttttgt cggatgacga 1495261 agtggagaag gtcgtcgacc atgtgattac tcagcagaaa gcgcaatatc aagaagaaat 1495321 gattcctgag gagacgacgg aaactcattc cgaggttact gatgaacttt atgatgaagc 1495381 tgttgaatta atcgtcggca tgcagacggc atctgtttca atgctgcaaa gaagattcag 1495441 aattggctat acgagagcgg cgcgcctgat tgacgcaatg gaggaacgcg gtgttgtcgg 1495501 accgtatgaa ggcagcaaac ctagggaagt attattatca aaagagaaat atgatgagct 1495561 ctcttcttaa tgaagggagt tccgctttct atagttgtca ataatgatat tatgtaaact 1495621 gatcaccttt ctatttattt tttcgacaaa acatgatata gttgtcccaa ttgttcaata 1495681 atttttatcg aaagtggttt acggagggga aacatgtcta caaaagctga taatcggcac 1495741 ttgtatttga aagtaattga acgaattaaa gaggatataa aaaatgggat ctacactgag 1495801 aaggaaaagc tgccttctga atttgagctt tccaaaaagc ttggtgtcag cagagcgacg 1495861 ctaagagaag ccttgcggat actggaagaa gagcatgtga ttatcagaag gcatggtgta 1495921 ggcacttttg tccattctaa gccgttattt ctttcgggta ttgaacagct gaacagtgta 1495981 accaagatga tagaacaggc gaatatgacc cctggcacga tttttctatc atcacaagtg 1496041 cttatgccgt ctgaagatga tacgaagaga tttcacttgg cagaagggca agaacttttt 1496101 taccttgaac gagtcaggac agctgacgga cagccgattg tgtattgtat agacaaaatt 1496161 ccgatgaata ttttgccgaa ttctttttct catcagcaag aatctatgtt tgacctgcta 1496221 gagaaaaatt caggctccgt aatcagctat gcagtaactg atatagaacc gatcggctat 1496281 cacgatacca tttctccagt gcttgaatgc gatccggaaa cagctctttt gctgttaaaa 1496341 caaacccatt acgatcagca cgataaaccg gtgctttatt ctttaaatta ttttagagcg 1496401 gataaattca gatttcatgt tttgcgtaaa cgattctaaa aacggacgcc tgtatgtgtc 1496461 tgttttttta tttgcactga ttcatgtttc tttgtacata ctttcattcc ggttaacgca 1496521 atatataagg gatgacaaga aagtgaatgg gtgaaaatgt tgagagagaa aaatggaatg 1496581 aaaaatatta ttgcattgtc ttctgtcccg cttgtgatga cactcgggaa ctccatgctg 1496641 attcctgttc ttccgatgat ggagaaaaag ctgtctgtga cttcatttca agtatcttta 1496701 atcattactg tatattcagt agtagcaatt atttgcattc cgattgccgg atatttgtcg 1496761 gatcgtttcg ggagaaaaaa aatattgctt ccatgcctcc tcattgcagg attgggggga 1496821 gccgtagctg cttttgcctc gacctatatg aaaaatcctt atgctatgat cttggcgggg 1496881 cgggttcttc aaggcattgg ttctgcaggt gccgctccga ttgtcatgcc gtttatcggc 1496941 gacctgttta aaggagacga tgaaaaggtc agcgcgggtc ttggcgatat tgaaaccgcc 1497001 aacacgtcag ggaaggtact gagtcccata cttggagcct tactggcttc ttggtattgg 1497061 tttgtaccgt tttggtttat tccgtttttc tgtttgatca gctttttgct cgtattgttt 1497121 ttggtggcca agcctgaaga agatgaagat gcgcctgctg tttctgagtt tattaagagt 1497181 gtgaagaaaa tttttaaaca ggatggtcgc tggctttata cggtcttcat tatcgggtgt 1497241 gtcattatgt ttttgttatt tggcgtatta ttttatttat cagatacgct ggagaacaag 1497301 tatgctattg acggagtagc taaaggcgga ttactggcaa tcccactttt gtttttgtca 1497361 accagttctt ttatagctgg caaaaagatc ggtaaagata aaggccgaat gaaattttgc 1497421 gttgttacag gaatgattct gttaaccctt tcgtttattg ccttgtggtg gaaccacagt 1497481 ttttattttt tatttgtctt tttaagcttt ggcgggattg ggattggaat ggctcttcct 1497541 gctttagatg cattgataac cgaagggatt gaaagtgaac aatgcggaac catttcctcc 1497601 ttttacaata gcatgcgctt tataggagta gctctcggtc cacctgtttt tgctgcatta 1497661 atgtctaatg caaactggat tattttcata ctctcggcgt tttgcagcat cgtttcttta 1497721 tttttagtgc tctttactgt agatgctaaa aaaagtgaag aagaaaaaaa cttagggacg 1497781 gtctagccag ccgtcttttt ttgcgctttc ttgcacagtt tacaactgta cctatacagc 1497841 atgcggaggt tattgtttcc ttataaatcc tacagttgct ataattacat gaaagagtgt 1497901 ttctgcggat gctgaaaatt ggtcataata catactaatt aagaaatgaa cgaaggaggt 1497961 tccatatgtc atatgttaat gaactcaaat caaagcacgg cggtttaacc gcacacattg 1498021 taaaaacaga aaaattcaaa accgtctcgc ttatttttaa gatgcttgcg ccgctgacaa 1498081 aggatcaagt caccaaaaga gcgcttctcc cgcatgtgct tcttcgcgga acgaaaagcc 1498141 atccgaaaac cgcaggattg cgttcatact tggatgagct gtacggcacg tcagtatcgg 1498201 ctgatcttac gaaaaaagga gagcggcatg tcattacgtt caggcttgaa atcccgaatg 1498261 aaaaatattt aaaagaccaa acgccgcttc tcgagaaagg gctccagctt ctcgcagaac 1498321 tcgtcttttc acctgctttg gagggagacg cttttcagtc acaatatgtg gctcaagaaa 1498381 aacggacgct taagcaaaga atccaagccg tctatgatga taaaatgcgt tattcgaatt 1498441 taaggctgat acaggaaatg tgcaaaaatg atccttacgc gcttcatgtc aatggtgaaa 1498501 tcgacgatgt cgatgacatt acggcagagc aattatacga aacataccaa agcgctatcc 1498561 aaaaagacca gcttgatcta tatgttgttg gcgacgtgga cagtaaccag gtacaatcgg 1498621 caattgataa gtatttcaaa acagaagagc gcactcttgg catgattgaa aacaatcacg 1498681 ctgatgaaaa agttcagcca aaagaagtaa ttgatgaaga ggatgtcaag caaggaaaac 1498741 tgaatatcgg ctaccgcacc agcatcactt atacagatca ggattatcct gctttacaag 1498801 tgtttaacgg attgttcggc ggattctctc attctaaact tttcattaat gttcgggaaa 1498861 aagccagtct tgcttactac gcggcttcgc gtatagaaag ttttaaaggc ttgttaatgg 1498921 tgatgtcagg cattgaagtg aaaaattttg aacaggcggt ttcgattatt gctgagcaat 1498981 tccaggcaat gaaaaatggc gatttcagtg agcaggatat agcacagaca aaggccgtta 1499041 ttcgaaatca agtgctggaa acgattgata cagcatacgg tttatctgag tttttatatc 1499101 agcaggccgc tgctcaagtc gagattccta tcgaagactt tcttgccaat attgagaatg 1499161 tcacaaaaga ggatatcatt aaagccggcg aaaagattca gcttgatacg acttatttct 1499221 taaaagggac ggagggtgca tcttgatcaa accaatcgaa tatgaacagc ttcaggagac 1499281 gctgtatcat gaaaaaatgt ccaacggcct tgatgtttac gttttgccga aaaaaggctt 1499341 caacaagaca tatgcggtct ttacaacaaa gtacggctcg atagataacc ggtttgtccc 1499401 tttaggtaaa aacgagatgg ttcacgtgcc ggacgggatt gctcactttc ttgagcacaa 1499461 gctgtttgag aaagcggacg gagacgtttt tcaagatttc agcaaacagg gggcttctgc 1499521 caatgcgttt acgtcattta caagaacggc ttaccttttc tcaagcacat caaatgttga 1499581 acgcaattta gagacgctta tcgatttcgt acaggaccca tattttactg aaaaaacggt 1499641 tgaaaaggaa aaagggatta tcgggcagga gattaatatg tacgacgata accctgattg 1499701 gaggctttac ttcggggtca ttgaaaacat gtacaaagag catcctgtca gaattgacat 1499761 agcgggaaca gtggaaagca tttcacatat tacaaaagac cttctttatg aatgctatga 1499821 aacgttttat cacccgagta acatgctcct tttcattgtc ggccctgtag atcctgaagc 1499881 gattatttct caggtaagag aaaaccaggg gaaaaagccg tatactgatc agccggagat 1499941 caaacgagaa gaagtgaaag agcaagaagc ggttttccga aaagaaaaag agatcaaaat 1500001 gaacgtgcag ggaccgaaat gccttgttgg gctgaaatcc aaaaatccgt ttaaattagg 1500061 caaagagctc ttaaagcatg aactttcaat gaacttattg cttgaagctc tttttggcaa 1500121 aagctctgcc cagtatgaat cactttatga aaaaggatat attgacgaaa cgttcagctt 1500181 tgattttact gctgaatatg ggttcggttt tgcggcgatc ggcggagata cgcctgagcc 1500241 tgatcaattg gctgaagaca tttcaagcat gcttttgcgc gccggtgaac tgattactgc 1500301 tgaaaagatt gaacttgcca gaaagaaaaa gatcggcaca ttcttaaaag cgctgaattc 1500361 ccctgaatac atcgccaatc aatttacccg ttatgcgttc ttggatatga gcctgtttga 1500421 tgttgtaacg gtactcgagc agattaccct cgaggatgtc cagaacgtaa tacaagagga 1500481 aatcgctgca gacagactga ctgtctgcaa ggttgttcct aaatcataaa caaaacatcc 1500541 ctccagtgtg aggggtgttt ttctgcggaa agaaggaaag aggatgaaca aaacagcact 1500601 aatcaccgga gcaagcggcg gcattggcaa aagcatcagc gaaacccttg cagctagagg 1500661 atacaatctg ctgctgcatt acaatacaaa tcaaaacgcg gcagcggagc ttgctgaaaa 1500721 actaagtcag atgtttggcg taaatgcgga gatattacaa gctgacctgt ccgcgcaaga 1500781 tggagcagat aagctgacaa gttcaattgt tcagccgatt gatgcgattg ttttaaacag 1500841 cggacgaagc cattttgggc tgattacgga tgtagataac gcaacggtcc aggaaatggt 1500901 tcagcttcat gtggcgagtc cgtatatgct gacgagaaac cttctgccag gcatgattcg 1500961 gaataaatcg ggagcgattg tggctgtcag ctcgatttgg ggagagactg gagcatcctg 1501021 tgaagtgttg tacagcatgg caaaaggagc tcagcattca tttgtaaaag gattggctaa 1501081 ggagctggcg ccaagcggaa tcagagtaaa cgccgtagcg ccgggtgcag ttgatacaaa 1501141 tatgatgaat caatttaccc cggctgaaaa agaagagatc gctgatgaga ttccgatcgg 1501201 ccggctggcc cggccgcaag aaattgcgga tgcaacagct tttctcctgt ctgaaaaagc 1501261 gtcatatatc accggccaaa ttctgtcggt gaatggcggc tggcactgct gatccgaaaa 1501321 tattcggtgt atagtttctt ttgcgaagga cacaataatc ttgtaacttc acatgaaatg 1501381 gaggaaacaa gcatgtcagt attagaaaac tgggatagct ggaaaaactt ccttggcgac 1501441 cgtctgaact atgcgcaaga taaaggtatg agccaggata cgattacaga tcttgcgaca 1501501 gaaatcggca gctacttggc taatgaagtg gaatctaaga acgagcagga aaaagtgctg 1501561 gcagatcttt ggagtgtagc atcaaaagat gaacagcacg ccattgccaa tatgatggtt 1501621 aagcttgttg aaaataacag cactcactag gaagagaggg gatttttcct ctctttttta 1501681 tgttttcctc atcacagcaa cattcttctt tctaattaga gaaaaatgct ttatgataaa 1501741 ggaaggtaaa attttgccac aatgaagggg gtatatcatt tggcaaagct cgaatggtat 1501801 tttgaatatg aaattcaagt gaaccgcccc ggactgctcg gggatatttc atctcttctt 1501861 gggatgcttt ctatcaacat cgtaacgata aacggcgtcg atctttccag aaggggaatg 1501921 ctcctcaggt gccgccatat agatcaaatt aaacgattag aatcaatctt aaaaacgatg 1501981 gaaacaatta aagtaacgaa gcttagagaa ccgaggcttc gcgaccgtct tgccgtacgc 1502041 cacggccgtt atattcaacg ggatgccgat gacaagaaaa cgttccgctt tgaacgggac 1502101 gagcttggct tattagtcga ttttatggcc gaattgttca aaaaagaagg ccataaatta 1502161 atcggaatca gaggtatgcc gcgtgtcggg aaaacggaat cgattgtagc ctctagtgtg 1502221 tgcgagcaaa aggtggctgt ttgtgtcatc aaccttgctg aagcagacga taagaagcca 1502281 gctgattgcc gatgaataca gcactgaaaa tgtctttatc gttgacggaa ttgtgtcaac 1502341 acgaagaggg tcagaacgcc atctccagct ggtccgagaa atcatgcggc tgcctgcaac 1502401 aaaagtggtg gagcatccgg acatattcgt tcaaaataca gagtatacac tagatgactt 1502461 tgattatatt attgaactga gaaatgaccc tgatgaggtt attacatatg aacatgccga 1502521 ggaaccccaa atgtttgatc aatccgggtt ttcaagcttt gatttttaaa attggaaggt 1502581 gtttgttgtg actgaactag gaatccggct caaagaagcc agagaggaaa aagcaatgtc 1502641 attggatgat ctccaagcgg caacaaagat tcaaaaaagg tatttaaccg ccttggagga 1502701 aggaaactat gacattattc cggggaagtt ttatgttcgg gcattcatca agcaatatgc 1502761 agaagccgtt gggcttgatg cggatcagct gtttgaggag cataaaaaag atatccctaa 1502821 tacgtatcat gatgatgtgt ctgaaaagat ctccggcatg aatcttcaaa aggaaatgcc 1502881 aaagccagca tctaaggcgc tggagctgct gccaacaata cttgttattc tcggcgtgat 1502941 tgtcgtgatt gccattgtgt acgcgatcat tcaatttgcc aatcacaaaa acagtgatga 1503001 tcacaatgcg gcatcagaaa aagcaattac gcaaagtgag agcaagtacg aaatccctaa 1503061 agattcaacg ctgaaagaga atcaaaataa cagctctgaa aaagagacag acactaaaaa 1503121 agaaacgaaa gaaaacgaag ataagaaaaa agaaaatgac agtgagaagc tggagattaa 1503181 agctgctggc actgaaggat cgttaacgac ttatgaagtg tccggcgctg ataaaatcga 1503241 gctggaactg aaggcatcag acagctcctg gattagagtg cgcgatgaaa acagcagctc 1503301 tttaaaagaa ggaacgctga aaaaagacga aacctataaa aaagacataa ctgatcagaa 1503361 acaagttgat atccgcaccg gatatgcacc taatctgaaa ataaaaatca acggtaaggt 1503421 tctttcatat gaacttgatc cgaaaaaagt gatggcacaa accataaaga ttgtaaataa 1503481 aaaggaagaa aagtcatctt aattaccaga tgacttttct tcacgtccga gtatgaaatt 1503541 ggaggggctt tatgtttaac ttaccaaata aaatcacact agctagaatc gcattaatcc 1503601 caatcttcat gattatcatg ctggcgccgt ttgactgggg caggctcgaa gttggagacg 1503661 aatccatccc ggtcgcacat ttggcggggg ccattctatt tattattgca tctacaacag 1503721 actgggtgga cgggtattat gcccgaaaat taaatctcgt aacaaacttc gggaaatttc 1503781 ttgatccgct tgcggacaaa ctgctcgtat ccgcagcgtt aattatcctt gttcaatttg 1503841 atctcgctcc agcttggatg gtcattgtga ttatcagcag ggagtttgcc gtgacaggtt 1503901 taaggcttgt cttagccgga acaggagaag tcgtagctgc taacatgctt ggtaaaatca 1503961 aaacctgggc acagattatt gcggtatctg cattgcttct tcataatctt ccatttgaac 1504021 ttgtgtcatt cccgtttgca gacttggcgc tgtgggtagc cgtcttcttt actgtcgtct 1504081 caggctggga atatttctct aaaaattggg aagcgttaaa aacatctaac taagaaagaa 1504141 ggacttcgtc atggaatttc caaaaaaagc agaaataatt gcagtcggtt cagagttgct 1504201 gcttggtcaa atcgccaata caaatgctca atttatcagc aaacagctcg ctgaaatcgg 1504261 ggtcaacgta ttttatcata cagcggtcgg agataacccg gagcggctga agcaggtcat 1504321 ccgcattgct gaagaacgct ctgacttcat tattttttca ggagggcttg gacccacaaa 1504381 agatgatctg acgaaagaaa cgattgcaaa tacgctggga cgtccgcttg tgttaaatga 1504441 tgaggcattc caatccattg aggactattt caaacgaaca aaacgcacga tgtcacctaa 1504501 taaccgaaaa caggcgcttg tgatcgaagg ctctgacgtg ctggcgaatc actttggaat 1504561 ggccccggga atgctcacag agcatgaatc gcgctattat atgcttcttc ctggaccgcc 1504621 gagcgaattg cgtccaatgt ttgaaaacga ggcaaagcct cttctgctga aaaagatggg 1504681 ttcaaatgaa aaaattgtgt caactgttct tcgctttttc ggtatcggtg aatctcagct 1504741 tgaagccgat ttggaagata ttattgatgc acaaaccaat ccgacaattg cgcctttggc 1504801 ggctgatgga gaggtgacgc tgcgtctgac agccaaacac gccgatgaaa aggaaacaga 1504861 gcgtctgtta aaagaaacag aggccgttat cttagagcgt gtcggtgaat ttttctatgg 1504921 ttacgatgat acttctcttg taaaagagct atctatagca tgtaaggaaa aaggcataac 1504981 aatttctgcg gcagaaagct ttaccggagg gctgttttct gaatggctga cggatcatag 1505041 cggtgcctca aaattatttg ccgggggcgt tgtttgctat acaaacgacg tgaagcagaa 1505101 tgtgcttggt gtcaagaagg aaacattaga tcgttttggg gcggtcagca aggagtgcgc 1505161 atccgaactg gctaagggtg ttcaaaaact cactggcagc gatatcggca ttagctttac 1505221 tggtgtagca ggacctgatg ctcaagaagg gcatgagcct gggcatgtgt ttatcggcat 1505281 ttccgcaaat ggtaaagaag aggttcacga gtttcacttt gcgggctcca gaacggggat 1505341 cagaaaacgc ggcgctaaat acggctgcca tttaatctta aagcttttag agcaaaaata 1505401 atattttcag cacattatcc tcctaagaaa acatgatttc tctgatacat tatgatattt 1505461 tgataggaat cacgccaaga aaaaatccga atatgcgttc gcttttttct tggcaaatcc 1505521 cttcaaacag ggtatagtat atgtagtggt aacataaagg aggaaaaaat agaatgagtg 1505581 atcgtcaggc agccttagat atggctctta aacaaataga aaaacagttc ggcaaaggtt 1505641 ccattatgaa actgggagaa aagacagata caagaatttc tactgtacca agcggctccc 1505701 tcgctcttga tacagcactg ggaattggcg gatatcctcg cggacggatt attgaagtat 1505761 acggtcctga aagctcaggt aaaacaactg tggcgcttca tgcgattgct gaagttcagc 1505821 agcagggcgg acaagccgcg tttatcgatg cggagcatgc gttagatccg gtatacgcgc 1505881 aaaagctcgg tgttaacatc gaagagcttt tactgtctca gcctgacaca ggcgagcagg 1505941 cgcttgaaat tgcggaagca ttggttcgaa gcggggcagt tgacattgtc gttgtcgact 1506001 ctgtagccgc tctcgttccg aaagcggaaa ttgaaggcga catgggagat tcgcatgtcg 1506061 gtttacaagc acgcttaatg tctcaagcgc ttcgtaagct ttcaggggcc attaacaaat 1506121 cgaagacaat cgcgattttc attaaccaaa ttcgtgaaaa agtcggtgtt atgttcggga 1506181 acccggaaac aacacctggc ggccgtgcgt tgaaattcta ttcttccgtg cgtcttgaag 1506241 tgcgccgtgc tgaacagctg aaacaaggca acgacgtaat ggggaacaaa acgaaaatca 1506301 aagtcgtgaa aaacaaggtg gctccgccgt tccgtacagc cgaggttgac attatgtacg 1506361 gagaaggcat ttcaaaagaa ggcgaaatca ttgatctagg aactgaactt gatatcgtgc 1506421 aaaaaagcgg ttcatggtac tcttatgaag aagagcgtct tggccaaggc cgtgaaaatg 1506481 caaaacaatt cctgaaagaa aataaagata tcatgctgat gatccaggag caaattcgcg 1506541 aacattacgg cttggataat aacggagtag tgcagcagca agctgaagag acacaagaag 1506601 aactcgaatt tgaagaataa aaataaaata agtttcaaat gatacaaaag gctgagtgaa 1506661 aaactcagct tttttgtatt ttgcaaaaaa atgataaaaa tattgctttt tttgacaact 1506721 tttttagggc tttattcgtc taacaaaacg tgtgcaaaat ggaatttatt ttgggaggaa 1506781 aaaatgaatg acaagcccaa cccgcagaag aactgcgaaa cgcagacgga gaaaactaaa 1506841 taaaagagga aaactgttgt ttggtctttt agcagtgatg gtttgcatta cgatttggaa 1506901 tgctcttcat cgaaatagtg aagaaaacga accatctcaa gaaactgcag cggtttcaaa 1506961 taccgatcag aaaaaagagg tcaaaaagaa aactgccaaa aaatcagagg aacaaatcaa 1507021 aacagtggat cgaaaccaaa aaatcagcaa ttatttaaaa gagatcggtt tcagcggaac 1507081 agccatgatt gtcagaaatg gagaaatcgt aacaaataaa ggttttggct atgctgaccg 1507141 taaacactac attcaaaata atccattgac atctttttat gtcggttcat cacaaaaagc 1507201 gctgattgca actgctattt tgcagcttga ggaaaagggg aaacttcaga caagtgatcc 1507261 ggtaagcacg tatttacctc attttcccaa cggacaaacg attactttga agaatctgct 1507321 tacacataca tcggggataa acggacatat tgaaggaaac ggcgccatta ctccggacga 1507381 tttaataaaa gatatagaac ttcagggaat caaacgtcag ccgggcgtat gggactacaa 1507441 ggattccaac tattctgttc ttgcttatat tattgctgaa gtaagcggtg agccctatga 1507501 acagtacata aagaatcata tttttaaacc tgcgggaatg acgcatgcag gcttttacaa 1507561 aacatatgaa aaagaacctt atcctgccgt cgggtataag atggagggca gcaaaacagt 1507621 tacaccgtat atacctgatt tatcccagct gtatggagcg ggtgatattt atatgagcgc 1507681 tatagatatg tacaaatttg accaagcgct gatagacgga aaactgtatt cgcaaaaaag 1507741 ctatgaaaag atgtttacgc cagggagcag ctccacatac ggcatgggat tttatgttgc 1507801 tcccggaagc tattcaaacc atggtgttat gccgggcttc aatatcttga acagctttag 1507861 caaatctggg caaaccattg ttattttgtt ctcaaacatt caaaataatg ctaaattggg 1507921 ccaagtgaac aataaaatat accagcttct aaatcaagaa tgattggcga tcttcttttg 1507981 gatgaattgc attcggcacg tgaaaagaag actggcctgc aaacgttaag atggcaagct 1508041 tgacaagtat ttccgacaca tttacaatga agttgtaaca tttgtttttt taacatgatt 1508101 gttaaaccat ttaaacttga caagggcgat gaacacactc attccctgtg aaggttctgt 1508161 atgttgagaa aactagacaa tgtacatgcc gacacttttt aagcaacaac caagttcata 1508221 gcaagaggag gtgaaagtat gaccccaatt atgatggttc tcatctccat tttgctgatt 1508281 ctactcggtt tagttgttgg ctactttgtt cgtaaaacca ttgccgaagc gaaaattgcg 1508341 ggcgcacgcg gtgcagccga gcaaattctt gaagatgcga agcgtgatgc tgaagcactg 1508401 aaaaaagaag ctctgcttga agcaaaggat gaaatccaca aacttcgaat agatgctgaa 1508461 caggaagttc gtgaaagacg aaatgagctt caaaaacaag aaaaccgttt actccaaaag 1508521 gaggaaaacc ttgatcgcaa acatgaggga attgataaac gggaagcgat gttggagaag 1508581 aaagatcatt ctctgaatga acgacaacaa catattgaag agatggaaag caaagtggat 1508641 gagatgattc gtatgcagca gtctgagttg gaacgaattt cgagtctgac tcgtgacgaa 1508701 gcgaaacaaa tcattcttga gcgggttgaa aacgagcttt cacatgacat cgccatcatg 1508761 acaaaagaaa ctgaaaaccg tgcgaaagaa gaggcggata agaaagcgaa aaacattctt 1508821 tcactcgcct tacagcgctg cgcagcggac cacgttgccg aaacaacggt atcagttgtc 1508881 aatcttccaa atgatgagat gaaaggacgt atcatcggac gggaagggcg taacattcgt 1508941 acgcttgaaa cgctgacagg aattgacctg attattgatg atacgcctga agctgtcatt 1509001 ctttccggat ttgatccgat cagacgtgag acagccagaa ttgctcttga taaactcgtt 1509061 caggatggcc gtattcatcc ggcacggatt gaagaaatgg ttgaaaaatc tcgccgcgag 1509121 gtcgatgact atattcgtga gatgggtgag caaacgacat ttgaggttgg cgttcatggc 1509181 ctccacccag atctcatcaa gatcctcggc cgcttaaagt tccgtacaag ctacggtcaa 1509241 aatgtgctta agcattccat ggaagtcgca ttcttggccg gtctaatggc atcggagctt 1509301 ggtgaagacg caaagcttgc taaacgtgcg ggtcttcttc acgacatcgg gaaagcaatt 1509361 gaccatgaag tagaaggaag ccacgttgag atcggggtag agcttgcgac caaatataaa 1509421 gagcacccag tcgtgattaa cagtattgca tcacaccacg gggacgagga gccgacttcc 1509481 attattgctg tactggtagc tgcagcagat gcgctttccg ctgcaagacc tggcgcaaga 1509541 agtgagacgc tcgagaatta tattcgaaga cttgaaaaac ttgaagaaat ttctgagtcc 1509601 tacgaaggtg ttgaaaaatc atttgccatt caggctggac gcgaagtgcg aattatggtg 1509661 aagccggatt caattaatga tcttgaggct catcgactgg cgcgagatat ccgcaagcga 1509721 attgaggacg agctcgatta tccaggtcat attaaggtga cagtaatcag agagactcga 1509781 gccgtagagt atgcaaaata aagtgatgcg ctaagcatca ctttattttt ttgacggcaa 1509841 ggaattttca agaagaaagg atttacaaaa tgagaatttt atttatcgga gatgttgtcg 1509901 gttcaccggg ccgtgacatg gtcaaagaat atgtaccaaa gctaaaaaca aaatataagc 1509961 ctcactttac cattattaat ggtgaaaacg ccgcacatgg aaaaggcctg acggaaaaaa 1510021 tttatcacag cttaatccag tccggcgcag atgcaatcac aatggggaac cacacatggg 1510081 acaaaaaaga aatatttgat tttatagatg acgttccgaa cttggttcgc ccggcaaact 1510141 ttcctgaagg aacaccgggg aaagggatca catatgtgaa agcaaacggc aaagaactag 1510201 cagtcattaa tttgcaggga cgtacgtttt tgccgccgct tgatgacccg tttttaaaag 1510261 cggatgaatt gatcgcagaa gctgcgaaaa gaacaccgta catttttatt gactttcatg 1510321 ccgaagcgac aagtgaaaag ctcgcacttg gctggtacac ggatggacgg gcatcggctg 1510381 tagtaggaac tcatacacac gtgcaaacag cggataaccg cattttgccg aagggaacgg 1510441 catatattac tgatgtggga atgactggcc cgtatgacgg tatactgggg atggacagag 1510501 agacgattat taagcgattc aaaacgaacc ttccagtccg gtttactgtc gctgaaggaa 1510561 aaacaacgct cagcggagtt gtcattgaca ttgacgatca aacgaaaaaa gccgtgaaaa 1510621 ttgagcgtat tttaatcaac gatgatcaca tgttctttga atagttgaac atatggttat 1510681 tttataaaaa tattaaaaag aaaagcagga atatagcaac tccttagtga atatagtaaa 1510741 aatggaaggt agcccgctat ttttgaaaag cattgtgggg atggcttttt ggatagcaac 1510801 atctaataat gattgttcta atgaacactc acttatccat tgtaaaacta agggggagca 1510861 gaaatggaaa tcttaaaagt ttcagcaaaa tcgagtccaa attcagtggc aggtgcgctt 1510921 gcaggcgtgt tgagagagcg aggagccgcc gagattcaag cgatcggagc gggtgcatta 1510981 aaccaggctg taaaagctgt ggcgattgcc aggggatttg tggcgccaag cggcgttgat 1511041 ttgatttgta ttccggcttt tacagatatt caaatcgatg gggaagaaag aacagcgatt 1511101 aaattaatcg tggagcctcg ctaaaaacaa ataaagcatt ctcaacctgt ttgcgtaatg 1511161 caaacaggtt gtttttcatt tattgtgata ttttctcccg atagtatttt tagcacataa 1511221 atgagcgaat atacaaaatc agaaatgagc taaaacgttt caaaaaaaat ttccgcccat 1511281 ttttcaagac agatactttt gtccttctgg aaaagacagt tctgtttacg cttattccat 1511341 atcatggtac aatccgaata taacaagaat ttttcaagga ggattgtaca tgcagagtgg 1511401 aaagatgaaa gctctaatga aaaaggacgg ggcgttcggt gctgtgctga ctgaagttcc 1511461 cattcctgag attgataaac atgaagtcct cataaaagtg aaagccgctt ccatatgcgg 1511521 cacggatgtc cacatttata attgggatca atgggcacgt cagagaatca aaacacccta 1511581 tgttttcggc catgagttca gcggcatcgt agagggcgtg ggagagaatg tcagcagtgt 1511641 aaaagtggga gagtatgtgt ctgcggaaac acacattgtc tgtggtgaat gtgtcccttg 1511701 cctaacagga aaatctcatg tgtgtaccaa tactgctata atcggagtgg acacggcagg 1511761 ctgttttgcg gagtatgtaa aagttccagc tgataacatt tggagaaatc ccgctgatat 1511821 ggacccgtcg attgcttcca ttcaagagcc tttaggaaat gcagttcata ccgtactcga 1511881 gagccagcct gcaggaggaa cgactgcagt cattggatgc ggaccgattg gtcttatggc 1511941 tgttgcggtt gcaaaagcag caggagcttc tcaggtgata gcgattgata agaatgaata 1512001 caggctgagg cttgcaaaac aaatgggagc gacttgtact gtttctattg aaaaagaaga 1512061 cccgctcaaa attgtaagcg ctttaacgag tggagaagga gcagatcttg tttgtgagat 1512121 gtcgggccat ccctcagcga ttgcccaagg tcttgcgatg gctgcgaatg gcggaagatt 1512181 tcatattctc agcttgccgg aacatccggt gacaattgat ttgacgaata aagtggtatt 1512241 taaagggctt accatccaag gaatcacagg aagaaaaatg ttttcaacat ggcgccaggt 1512301 gtctcagttg atcagttcaa acatgatcga tcttgcacct gttattaccc atcagtttcc 1512361 attagaggag tttgaaaaag gtttcgaact gatgagaagc gggcagtgcg gaaaagtaat 1512421 tttaattcca taaaggggga taaacatgac gaaggaattt gagtttttaa aagcagagct 1512481 taatagtatg aaagaaaacc atacatggca agacataaaa cagcttgaat ctatgcaggg 1512541 cccatctgtc acagtgaatc accaaaaagt cattcagcta tcttctaata attacctcgg 1512601 attcacttca catcctagac tcatcaacgc cgcacaggag gccgttcagc agtatggagc 1512661 cggcaccgga tcagtgagaa cgattgcggg tacatttaca atgcatcaag agcttgagaa 1512721 aaagctggca gcctttaaaa aaacggaggc ggcacttgta ttccaatcag gcttcacaac 1512781 aaaccaaggc gtactttcaa gtattctatc aaaagaggac attgtcatct cagatgaatt 1512841 gaaccatgcc tctattattg acggaattcg actgacaaag gcggataaaa aggtgtatca 1512901 gcacgtcaat atgagtgatt tagagcgggt gctgagaaag tcaatgaatt atcggatgcg 1512961 tctgattgtg acagacggcg tattttccat ggatggcaac atagctcctc tgcctgatat 1513021 tgtagagctc gctgagaaat atgacgcatt tgtgatggtg gatgacgccc atgcatccgg 1513081 agtacttggc gaaaacggca ggggaacggt gaatcacttc ggtcttgacg gcagagtgca 1513141 tattcaggtc ggaacattaa gcaaggcaat cggagtgctc ggcggctacg ctgcaggttc 1513201 aaaggtgctg atcgattatt tgcgccataa aggccgtcca tttttattca gcacatctca 1513261 tccgccggca gtcactgcag cttgtatgga agcgattgat gtcttgcttg aagagccgga 1513321 gcatatggag cgcttgtggg agaatactgc ctattttaaa gcaatgcttg tgaaaatggg 1513381 tctgactctc acgaagagtg aaacgccgat tcttcctatt ttaataggtg atgaaggtgt 1513441 ggcaaagcaa ttttcagatc agctcctttc tcgcggtgtt tttgcccaaa gtatcgtttt 1513501 cccgactgta gcaaagggaa aagccagaat tcgcacgatt ataacagcag agcacaccaa 1513561 agatgaactg gatcaggcgc ttgatgtcat cgaaaagacg gcaaaggagc tccagctatt 1513621 gtaacaagag gaagagttta ctcttcctct tttgattcct tattgattat tattctcaat 1513681 gagtgtacaa tgataggttg ccagttgtgc agagcttcaa taacctttat actgaagggt 1513741 ggaagtttgg tttgaaagga gaaaatatga catgaatgaa aaacaaaaat tagagagcgg 1513801 acaagttcat ccatcggaca aaaaatccga gaaggattac agcaagtact ttgaagctgt 1513861 ttacattccg ccttctttaa aagacgcgaa aaaacgaggc aaggaagccg ttacttatca 1513921 taatgacttt aaaatttctg aacaatttaa aggattggga gacggaagaa agttctatat 1513981 ccgtacgtac ggctgccaaa tgaatgaaca cgatacagag gttatggcag ggatctttat 1514041 ggcgctcggt tacgaagcga caaactctgt tgacgatgcc aatgtcattt tgttaaatac 1514101 atgtgcaatc cgtgaaaatg ctgaaaacaa ggtgtttggt gagctcgggc acttaaaagc 1514161 actgaaaaaa aacaatcccg atctgatttt aggcgtgtgc ggctgtatgt cccaagagga 1514221 atcagtcgtg aaccgtattt tgaaaaaaca tccgtttgtc gatatgattt tcggaacgca 1514281 taacattcat cgcctgccgg agcttttgtc agaagcatac ctttcaaaag aaatggttgt 1514341 agaagtttgg tctaaggaag gggacgttat tgaaaacctt ccaaaagtcc gaaatggaaa 1514401 aattaagggc tgggtcaata tcatgtacgg ctgtgacaaa ttctgtacgt attgcattgt 1514461 gccttacaca cgcggaaaag aaagaagccg ccgccctgag gatatcattc aggaagtgag 1514521 aaggctcgca agtgaaggct ataaggaaat tactctgtta ggccaaaacg taaacgcgta 1514581 tggaaaagac tttgaagata tgacgtacgg acttggtgat ttgatggatg aactgagaaa 1514641 aatcgatatc ccgagaatcc gttttacaac gagtcatccg cgcgactttg acgaccgcct 1514701 cattgaagtg ctggcaaaag gcggaaatct gcttgatcac attcatcttc cggttcaatc 1514761 aggaagctca gaagttctca agctgatggc ccgcaaatat gacagagagc gttacatgga 1514821 gctggtgcga aaaattaaag aagcaatgcc aaacgcttct ttgacaacgg acattatcgt 1514881 cggatttcca aatgaaacgg acgaacagtt tgaagaaacg ctttctctat accgtgaagt 1514941 ggagtttgac agcgcctata cgttcattta ctctccgcgt gaaggcactc cggctgctaa 1515001 gatgaaagat aatgtaccga tgcgtgtgaa aaaagaacgc ctgcagcgtc taaacgcact 1515061 ggtgaatgaa atttctgcta aaaaaatgaa ggaatacgaa ggcaaggttg tcgaagtatt 1515121 agttgagggt gaaagcaaaa ataaccctga tattcttgct ggctatactg aaaaaagcaa 1515181 gcttgtcaat ttcaaagggc cgaaggaagc catcggcaaa atcgtccgcg tgaaaatcca 1515241 gcaagcgaaa acatggtcgc ttgacggaga aatggtagga gaagcaatcg aggtgaaatg 1515301 agatgacgct ctactcaaaa aaagacattg tgcagcaggc tcgaaacctt gcaaaaatga 1515361 tttctgaaac agaagaggtt gattttttca aacgggctga agcgcaaatc aatgagaatg 1515421 acaaagtgtc cacaatcgtt aatcagatta aagccctgca aaagcaggct gtcaatctga 1515481 agcattatga aaagcatgaa gcgctcaaac aagtagaagc aaaaattgac gcgctgcaag 1515541 aagagcttga agagattcct gttatccagg aattcagaga ctcgcaaatg gaagtaaatg 1515601 acctactgca gctcgttgca cacaccattt ccaaccaagt cacaaatgaa atcatcacat 1515661 caaccggagg cgacctgctg aaaggggaaa ccggttcaaa ggtgaagcat tcaaataaca 1515721 gctgttctct ctaaacacgg tgcctttaca ggcccgtgtt tttttatcat ttgtgcggtt 1515781 aaaaatgaac taaataatct atgtaccaaa tgttcaattg gtttttctgt gctcagccgc 1515841 gtataaactt tatcgcactt ataagtaaag tttctaggca cccctgcata caatggaaca 1515901 gaaactttgt atttttatat tttatttata aaaatgcaca ctagacaaat gcccagcata 1515961 agataacacg aagaagaaca aggaggcatg ccggaatgtc tgaatacagg gaaattatta 1516021 cgaaggcagt agtagcgaaa ggccgaaaat tcacccaatg caccaacacc atctcgcctg 1516081 agaaaaaacc gagcagcatt ttgggtggtt ggattattaa ccacaagtat gacgctgaaa 1516141 aaattggaaa aacggtagaa attgaagggt attatgatat aaacgtatgg tactcttacg 1516201 cggacaacac aaagacagag gttgtcacag aacgggtaaa atatgtagat gtcattaaac 1516261 tcagatacag agacaataat tacttagatg atgagcatga agtgattgcc aaagtgcttc 1516321 agcagccaaa ctgccttgaa gtgaccattt cgccgaatgg aaataaaatc gttgtgcagg 1516381 cagaaagaga atttttggcg gaagtggtag gggaaacaaa ggtagttgtt gaggtcaatc 1516441 ctgactggga agaggatgac gaggaagatt gggaagatga gcttgatgaa gagcttgaag 1516501 acatcaaccc ggagttttta gtgggagatc ctgaagaata aaaaagggac taggggagac 1516561 agtaccccca agtctctttt ttatattgat atatcattct tttatcactt tttgtttatg 1516621 ttataatgaa ggttggaaaa tagaaacgtt gatacatagt gagggattaa acaatggccg 1516681 gttatacgcc tatgatacag caatatttaa aaataaaggc agagcaccag gatgcctttt 1516741 tattttttcg cctgggtgat ttttatgaaa tgttttttga ggacgccaaa aaagcgtcac 1516801 aagagctgga aattacgtta acgagcagag acggcggtgc ggctgaaaaa ataccgatgt 1516861 gcggtgtgcc gtatcattct gcttccgcgt atatcgaaca gcttattaaa aaaggataca 1516921 aagtggcgat ctgtgaacag acggaagatc cgaaagccgc aaagggcgtt gtgaaaagag 1516981 aagtagttca gctgattacg cccggaactg taatggacgg caaaggcatc catgagtcgg 1517041 aaaataattt tatcgcatct gtttcagcct gctcgaacgg atacggactt gctctgtctg 1517101 atttaacaac gggagaaaat ttggctgttt tgattgaacg gcttgaagac gtcatatcag 1517161 aaatttattc agtcggcgca cgggaaatcg tggtttcagg aagcttggat gccgatacag 1517221 tggcacagct gagagagcgg tgcggtgcaa cgatttcaat tgaagacgga gaaacagacg 1517281 aacacgtaac gatcattgag cacttaaata atgaagatat aacaaaaaca tttctgcgct 1517341 tatatacgta tttgaaaaga acccaaaagc gcagccttga tcatcttcag cccgtgcagg 1517401 tgtatgagct tgaggaagcg atgaaaattg acttgtactc aaagcgtaat ctggagctga 1517461 ccgaaacgat tcgttcgaaa aataaaaaag gctccctttt gtggctgctg gatgaaacaa 1517521 aaacggcaat gggaggccgg ctacttaaac agtggattga ccggccgctt atcagagtca 1517581 atcaaatcga agagcgccaa gaaatggtgg aaacattaat gtcccatttc tttgaacggg 1517641 aagatctgcg tgaacgttta aaagaagtat atgacttaga acgccttgcc ggccgcgttg 1517701 cattcggaaa tgtcaatgcc cgggatttga ttcagctgaa ggaatcgtta aagcaagtgc 1517761 ctggcatcaa acagctggtt gcttcactgg ctcatgacaa ggccaaggaa cgtgcaaagc 1517821 gcattgaccc ttgcggggat gtacttgaac tgctggaaga agcgctgtac gaaaaccctc 1517881 ctttatcggt aaaagaaggg aacctgatta aagatggtta taatcaaaag cttgatgaat 1517941 atcgtgatgc aagcagaaac ggaaaagact ggattgcccg cctggaacag caggagcggg 1518001 aatacacagg cattcgctct ttaaaggtcg gctttaataa agttttcggt tattacattg 1518061 aagtgacaaa agcaaacttg catttgcttg aggaagggcg ttatgagcgg aagcagacgt 1518121 taaccaatgc agagcgctac attacacctg aattaaaaga aaaagaagcg ctcattttag 1518181 aggcggaaaa taacatctgt gagctggagt acgagctgtt taccgagctg cgcgagaaag 1518241 tgaagcagta tattccgcgg ctgcagcagc ttgcaaaaca gatgagcgag ctggacgcac 1518301 tgcaatgctt tgcgacaatc agtgaaaatc gccactacac gaaaccagag ttctctaaag 1518361 atgaagtcga agtgattgaa ggcagacacc cggttgttga aaaagtcatg gacagccagg 1518421 aatatgtccc gaacaactgt atgatgggcg ataacagaca aatgcttctc attacaggtc 1518481 caaacatgtc agggaaaagc acgtatatga gacaaatcgc gctcatttcc attatggcgc 1518541 aaatcggctg ctttgtaccc gcgaaaaaag cggtgctccc gattttcgat caaattttta 1518601 cgcgaatcgg cgctgcagat gatttgattt ccggacaaag tacatttatg gtagaaatgc 1518661 ttgaagcgaa aaatgcgatt gtcaatgcga cgaaaaacag cctcattctg tttgatgaaa 1518721 tcgggcgggg aacgtccact tatgacggca tggcgctggc acaggcgatt attgaatatg 1518781 ttcacgatca tatcggcgcc aagacgctgt tcagcacaca ctatcacgag ctgaccgttc 1518841 ttgaggacaa gctgccccag ctgaaaaacg ttcatgttcg cgctgaagaa tataacggaa 1518901 cggttgtctt tcttcatcaa attaaagaag gtgcggctga taaaagctat ggtatccatg 1518961 tagctcagct tgccgaactg ccgggagatc tgattgcgcg cgctcaagat attttaaaag 1519021 agcttgagca ttcaggaaac aaaccggaag tgccggtgca gaaacctcag gtgaaagaag 1519081 agccggcaca gctgtccttt tttgacgaag cggaaaagcc ggctgaaaca ccaaagcttt 1519141 caaaaaaaga aaagcaagtg atcgatgctt tcaaatcact taatatactg gatatgacac 1519201 cgcttgaagc gatgaatgaa atgtacaagc tgcaaaagaa attacattaa aacggggtga 1519261 tgaatgtggc aaaagtcatc caactgtcag atgagctttc aaataaaata gcggcgggcg 1519321 aggttgtgga acggcccgcc tcagtcgtca aagaattggt ggaaaatgcg atcgacgctg 1519381 acagcacagt cattgaaatc gatattgagg aagcaggcct tgcatccatt cgggtcttgg 1519441 ataacggcga aggaatggag aatgaagatt gcaagcgagc tttccggcgc cacgcaacga 1519501 gtaaaataaa agatgaaaat gatttattca gggtgagaac gctcggtttc aggggagaag 1519561 ccctgccgag tatcgcgtca gtctctcatc tggagattac aacaagcact ggtgaaggag 1519621 ctgggacgaa gctcgtcctc caaggaggaa acatcatttc cgaatcgcgt tcctcaagca 1519681 ggaagggaac tgaaattgtc gtttccaacc tgttttttaa cacaccggcc cgtttgaaat 1519741 atatgaaaac cgttcataca gagcttggaa acattacaga tgtggttaac cgtattgctc 1519801 tggcgcatcc agaggtatcg atccgcctgc gccatcatgg gaaaaacctg cttcaaacga 1519861 acggaaacgg agatgtgcgc catgtactgg cagcgattta cggcacggct gtcgccaaaa 1519921 aaatgcttcc gctgcatgtg agctccttgg attttgaagt aaagggatat atcgccctcc 1519981 cagagattac acgggcgtcg agaaactata tgtcgtctgt ggtcaatggc cgttacatta 1520041 aaaatttccc gctcgtcaaa gcggttcatg aaggctatca tacgcttctg ccgatcggac 1520101 gccatccgat tacttttata gaaattacga tggacccgat tttagtcgat gtcaacgtgc 1520161 atccatcgaa gcttgaggtc cggctcagca aggaaacaga gcttcatgac ttaatacgtg 1520221 acggaattaa agatgtgttt aaacagcagc agctgattcc tagtgcccag gtcccgaaaa 1520281 aatcagcacc tgccatcaaa aatgagcagc agtttataac ctttgatgaa aagcctccgg 1520341 aaaaaaaagt tccggaaaaa tcgactgcgc catcttattc accgatgaag ctcagctcag 1520401 tcgtaaaaga gccggttgat gcggaggaaa aattgccccc tctccaattt gatgctcctc 1520461 ctatcgttga tcaggaacaa acccttgagg tgtccgatgt ttcagcagaa cagcctgaaa 1520521 catttgagca ggaatgccat gaggaacagc cgcagccagc gtctgatcgg gttccaatta 1520581 tgtacccgat tggccagatg cacgggactt atatattggc acaaaacgaa aacggcctat 1520641 atattatcga ccagcacgcc gcccaagaac gtattaaata tgagtacttc cgtgaaaagg 1520701 tgggggaggt tgagcctgag gtgcaggaga tgattgtacc gctgacgttc cactactcca 1520761 caaatgaggc tttgattatt gaacagcaca aacaagagct cgaaagcgtc ggtgtctttt 1520821 tagagtcatt cggctctaac agttacatcg tccgctgcca cccagcctgg tttccaaagg 1520881 gagaagaagc agagcttata gaagaaatca ttcagcaggt gctcgactcc aaaaatatag 1520941 atattaaaaa acttcgcgag gaagcggcga ttatgatgag ctgcaaaggc tccatcaaag 1521001 caaatcgcca cctcagaaac gacgaaatca aagcgcttct ggacgacctc cgaagcacat 1521061 cagacccatt tacatgcccg cacggccgcc cgatcatcat tcaccactcg acatatgaga 1521121 tggaaaagat gttcaaacgc gtgatgtagc gggggtggta ggcattgatc cattctctga 1521181 atgggaattc acggggcata cggataatag gggtatccgc catacaaata aggattaaat 1521241 aaagcgcttc ctataagccc gcctgcaagg ccgccgataa acggtcctcc aaaaaatccg 1521301 aatggccggc caaacccata accaaatccg ggtcttccaa acccgtaacc gaacccgaac 1521361 ggtcttccaa acccaaatgg tctcccgaat ccgaacggcc ttccaaatat tcttgtatct 1521421 tcagggctga aatgctctaa ctcgttcatg ttttctttcc tcctgtaata aagtgtagat 1521481 gatgcagtgt attcaccctg cccggatttg attgggcgaa tcgaggaaaa ggaggatgtg 1521541 aacacattgg gcctgtatca gtctgactgg tcaaaagcac cgccccacgc acatgcttat 1521601 catgtcaaaa caacgagaga acagggccat tatcatctca tcgaagggtt tactcagccg 1521661 gcaaacggat caaataccga tcagcataca cattactata cagggatcac ttcatttgaa 1521721 aacggccatt ttcatcggta ttacggaatc tcaggaccgg cgattccctt agcagatggc 1521781 acacattatc atgaaatcga agaaacgacg tatctggcct ataacgagcc gattgagatc 1521841 cagtacggag gggttgtgta cgatcccgga gatgacagaa gaaaaacgca tcgtcatacc 1521901 ctgaaaggaa agacaaggga aattgtcggc aatgagccgc tcggctggta gaaggatgtt 1521961 taccgatgca aaaaaagggc aaaatggata ggtggttgtc catgttgaat gctataatgg 1522021 ggggagattt ataaaagaga gtgatacata ttgaataata cgaagcagcc cgttgtcatt 1522081 ttagtcggac cgacggcagt ggggaaaacc aatttaagta ttcagctagc caaatcctta 1522141 aacgcggaaa ttatcagcgg agattcgatg cagatttata aagggatgga tattggaaca 1522201 gctaaaatta ccgaacagga gatggaggga gtgccccatc atctgattga cattttagat 1522261 ccccaagact ctttctctac tgccgattat caaagcttag taagaaataa aatcagcgag 1522321 attgcaaata gaggaaagct tccgatgatt gtcggcggta cagggcttta tatacaatct 1522381 gtgctttacg attatacatt tacggaagag gcaaatgatc ccgtgtttcg agagagcatg 1522441 caaatggctg ctgagcggga aggcgctgac tttcttcatg ccaaacttgc tgcagcagat 1522501 cccgaggcag cagctgcgat tcatccgaat aatacaagaa gagtcattcg cgcactggaa 1522561 attttacata cgtccggaaa aacgatgtcc cagcatttga aggaacaaaa acgagaactt 1522621 ctgtacaatg cagtgttaat tggcctgaca atggatagag acacgcttta cgaaagaatt 1522681 aatcagcggg tcgatttgat gatgcagtca ggccttcttc cggaagtgaa acgcttatac 1522741 gacaagaacg tgagagactg tcaatcaata caggcgatag gctataaaga gctgtatgca 1522801 tattttgacg gttttgtgac actttccgat gctgtcgaac agctaaagca gaactcgagg 1522861 cggtatgcga aacgccagct gacgtggttt cgcaacaaaa tgcaggtcac atggttcgat 1522921 atgacaccgc ctgttgatat ggagctgaaa aaaaaggaaa ttttcacaca tatagcagga 1522981 aaactcgaac tttaatcgaa actgtatgat atagagaatc aaggaggacg aaacatgaaa 1523041 ccgattaata ttcaggatca gtttttgaat caaatccgga aagaaaatac gtatgtcact 1523101 gtttttttgc tgaacggctt tcagttgcgg ggccaggtga aaggctttga taactttacc 1523161 gtattgttgg aatcggaagg taagcagcag cttatatata aacatgcgat ctcaacgttt 1523221 gcgccgcaaa aaaacgtcca gcttgaactc gaatagatca aaaaatgcca tgtcaagaca 1523281 tgaggaaagg ctgtcggggg ttcccggcgg ccatttttaa catgaatcca cttttgctcc 1523341 aagctttttg tgtaagctga ccatgccaag gcacggtctt tttttatgag aacaacatac 1523401 ggaagtaaaa atggtatatt atgtataaaa tgaatttggg agtgatcgat cttgtttgaa 1523461 agtgaagcag aactgagacg aatcaggatt gcacttgtat ggatagctgt ctttttactg 1523521 ttcggggcgt gcgggaatca agataccatt attgaaacag acaacggcaa ttcagactat 1523581 gaaacgcctc agcccacctc gtttccactt gaacataacc attttggcgt tatggaggac 1523641 ggctatatca aaatttatga gtataatgag tcccgcaatg aggtaaagct gaagaaagaa 1523701 tacgcggatg atgagcttga ataaaattca caagcattcg aatttacaaa gcggatgcca 1523761 gccgctaaac taaatacaga cacagatcaa acagagggtg aaaacatgaa gcataaagtg 1523821 atcgtgaatc attgggaaga aatttgcgaa gatgattctt gctatgaata cggaacaagt 1523881 atcattgtga acggaaaaga attaatcaga gaagcgtcaa ttatcactgc tttgaaggcg 1523941 gttttagaag agatcggcgc ggatgttgaa atagaagaaa cagtagagag cgaaaaatgc 1524001 tgtgatagct taagaaaaaa aaatctagac tactaagcag ttttttttca tgttatgata 1524061 tacatcggct aaaaacgaca ccccgagtag gacgagagat gattctcgtt ctgctctctt 1524121 ttttgggccc taatgagtct gcccgtttgc ctgatttgat caaaatatga atttttcata 1524181 aaaacgaatc tatatattgt gtttttgcta gagggtagta tactatatat agtgttagtg 1524241 atgagagatt catatttttt gataggtcgt gataaaacgt ggtacaaatc atatttgatt 1524301 cgaaaacagg gaatgttcag cggtttgtga ataaaacagg ctttcagcag atacgcaagg 1524361 tggacgaaat ggaccacgtg gacactccgt ttgttttggt cacctacacg acaaacttcg 1524421 gccaggtacc ggcatcaaca caatcatttc tcgaaaaata cgcccatctc ttattgggag 1524481 tcgctgcgag cggcaacaaa gtatggggcg ataactttgc aaaaagcgcc gataccattt 1524541 caagacaata tcaggtgccg atcttgcaca aatttgaact cagcggcaca tctaaagacg 1524601 ttgaattgtt tactcaggag gtagaaagag ttgtcacaaa atcaagtgcc aaaatggatc 1524661 cagttaaata acgaaatcat gatccaaaaa gatgggaaat tccagtttga taaggataaa 1524721 gaagctgtac atagctattt tgtagattat atcaatcaaa acacagtctt ctttcacaat 1524781 ttaaaagaga agctggatta tttggttgaa aaccaatact acgaagagga attcttaagc 1524841 ctttattctt ttgaagacat taaagaagtg tttaagacag cttacgctaa gaagtttcgt 1524901 tttccttcct tcatgagtgc gtttaaattc tataatgact atgctttgaa aacgaatgac 1524961 aagaaaaaaa tcctcgagcg ttatgaggac cggatctcaa ttgttgcgct gttcttcgct 1525021 aacggcgaca ctgagaaagc aaaagaatat gtaaacctga tgatcaatca agaatatcag 1525081 ccgagcacac cgacattttt gaatgccggc agaaaacgcc gcggtgaact tgtgagctgc 1525141 ttcttgctcg aagttaatga ttctttaaat gacatttcaa gagcaatcga tatctccatg 1525201 cagctttcta agcttggtgg cggggtttct cttaacctgt ccaagcttcg cgcgaaaggt 1525261 gaagccatta aagatgttga gaatgcgaca aaaggcgttg taggcgtcat gaagcttctt 1525321 gataacgcgt tccgttacgc tgaccaaatg ggacaaagac aaggctccgg cgcggcgtat 1525381 ttaaacattt tccaccgcga tatcaatgat tttcttgata cgaaaaagat ttctgcggat 1525441 gaagatgtgc gtgtcaaaac gctttcgatc ggtgttgtca ttccggataa gttcgttgag 1525501 cttgcacgcg aggacaaagc ggcttatgta ttctacccgc acacgattta taaagagtac 1525561 ggccagcaca tggatgagat ggacatgaac gaaatgtacg acaagtttgt cgacaaccct 1525621 cgggtgaaaa aggaaaaaat caacccgcgg aaactgcttg aaaaattggc gatgcttcgt 1525681 tctgaatcag gctatccata catcatgttc caagataacg tcaataaagt gcatgcgaat 1525741 aaccatattt ccaaggtcaa attttctaac ctttgctctg aagtgctgca ggcatctcaa 1525801 gtttcttcat acacagacta tgatgaagaa gatgaaatcg gtctggatat ttcctgcaac 1525861 ctgggttcgc ttaacattct caatgtcatg gagcataaat caatcgaaaa gacagtcaag 1525921 cttgcgacag actctttaac acacgtgtct gaaacaacag acatccgtaa tgcgcctgct 1525981 gtaagacggg caaacaaagc gatgaaatca atcggcctcg gtgctatgaa ccttcacggc 1526041 taccttgcgc aaaacggcat tgcgtatgaa agtccggaag cgcgtgactt tgcaaacacg 1526101 ttctttatga tggtgaattt ctactccatc cagcgttctg cggaaatcgc aaaagagaag 1526161 ggcgaaacgt ttgatcaata tgaaggatca acctatgcga caggtgaata cttcgacaaa 1526221 tacgtttcaa ctgatttctc accgaaatac gaaaaaatcg ctaatctgtt tgaaggtatg 1526281 catatcccga cgacagagga ctggaaaaag ctaaaagcat ttgtcgctga acacggtatg 1526341 tatcacagct acagattatg cattgcgccg acaggctcta tctcatacgt tcaatcaagc 1526401 acggcgtctg ttatgccgat tatggaacgg attgaagaac gaacatacgg caactcaaaa 1526461 acgtactacc caatgcctgg gcttgcatct aataactggt tcttctataa agaagcctac 1526521 gatatggaca tgttcaaggt tgtggatatg atcgccacta tccagcagca cattgatcag 1526581 ggaatcagct ttacattgtt cttaaaagac acaatgacga cccgagattt aaaccgaatc 1526641 gatctgtatg cacatcatag aggaattaaa accatttact atgcaagaac gaaagatact 1526701 gggcaagaca gctgcctttc ttgtgttgtt tgattaaagg agagtttata gtgacaaaaa 1526761 tttatgacgc agcaaactgg tcaaagcatg aagacgattt tacccaaatg ttctataacc 1526821 aaaacgtgaa acagttctgg cttccggaag agattgcttt aaacggcgat ctcctcacat 1526881 ggaagtacct cggaaaaaat gagcaggaca cttatatgaa ggtactggcc ggacttacgc 1526941 ttcttgacac agagcagggg aatacgggga tgccgatcgt ggctgaacac gtagatggcc 1527001 accagcggaa agcggtgctg aactttatgg cgatgatgga gaacgctgtc catgcgaagt 1527061 cgtactctaa tattttcatg acccttgcac cgactgaaac gatcaatgaa gtatttgaat 1527121 gggttaaaca aaataaatat ttgcagaaaa aagcgcaaat gattgtcggg ctttacaaag 1527181 ccattcaaaa agatgatgaa atttcactgt tcaaagccat ggttgcttcc gtctatctgg 1527241 aaagcttcct tttctacagc ggtttctatt atccgttata tttctacgga caaggaaaac 1527301 tgatgcaaag cggtgagatc attaacctga tccttcgtga cgaagcgatt cacggcgtgt 1527361 atgtcggtct ccttgctcag gaaatttata ataaacagac agaagagaaa aaagcagagc 1527421 ttcgtgaatt tgcgatcgac ctcctgaatc agttatatga aaatgagctt gagtatacag 1527481 aggacttgta cgatcaagtc gggctctcac atgatgtaaa gaaattcatc cgctataatg 1527541 cgaataaagc gctgatgaac cttggatttg atccatactt cgaagaggaa gacattaatc 1527601 cgatcgtttt aaacggatta aacacaaaaa caaaatcgca tgacttcttc tctatgaagg 1527661 ggaatggcta taaaaaagcg acagttgagc cgctcaaaga tgatgacttt tattttgaag 1527721 atgaaaaaga gcagatataa tatctgctct tttcggcttg aaggttcaaa tgaggaggac 1527781 gcagtaccca tgggaaaaat ggacgaaatg attttagttg ccccgcgcga tgatgtgttt 1527841 aaaaaagaaa gcttaacctt ccagggcgtg tacagtgaag atagcagagt agcagaaatc 1527901 atggctcaga ttgaagcggc ctatcgtgaa atgagaagag gggacgcaga agaagatccg 1527961 cgtttcaagc agccgatacc ttatgtcgtc attaagcgtg aagatgaagt ttttctttac 1528021 gagcggctgg ctggcggcgg tgaatcacgt ctgcacaaca agctttctct cggttttggc 1528081 ggccatatga acgccatcga aggggcagct tcatttgctg aagtcttaaa gctgaacaca 1528141 gaccgtgagc ttgaggaaga actgcaaata aatgaagaag ataaacaggc gattgtcaca 1528201 ctgggattga tcaatgatga tgaaaacagt gttggcaaag tgcatatcgg tattctttct 1528261 gcgcttcaat taaagcctgg cgcacaagtg gaagtgaagg agaaagaaca aattgcgggt 1528321 aaatggatga aagtttctga attaaaacag gatgatatct acaaccgtct ggaaacatgg 1528381 tcacagtttg ttgttgatat tcttgaataa aaaaacccgg tttctcgcga tgaggagccg 1528441 ggttttttta tgagacgctc gtccccgtct cggctatgat tctaggatca caatagcgtc 1528501 aaagccggca tttttcgctc tggcagcgag ggtgtctgca ttgtctttgg atgaaaatgc 1528561 gccaatctgc actttgtata atccgtcctt taaaaggaca atcgagtcaa aacctttggc 1528621 ttcggcatta cttgcgagcg agtcggcatt cgctttgact ttaaatgcgc cgatttgaac 1528681 cttatataac cctgagctgg aagtcttttt aaggttaaag gcttgctcca gcccgtttgc 1528741 atgtcctctc gctaagcttt gaataaaact gctcgttttc agcttatttg catcggaaac 1528801 ggtatcaatg aagccgttct cggtcaagag ggcaggcatt gccgactccc ttaggacgtg 1528861 gaagttcgct gtttttttgc cgcgatcggc aaagtcgaca gcttgtatca cttcagagtg 1528921 aattgtcgat tgataagtcg tcgtcggggc tcctacatct ggataaatat agctttcaaa 1528981 acctgtgcct cccccggaat taacgtgaat ggacaaaaag aaatctgctc cccagttatt 1529041 tgcggcattt gtccggtcgt ttaagctgac atattggtcg cttgtccggc tcagcagcag 1529101 agaaacgcct tcatattcat tagttaatat cgtacgtaag gctaaagcga tttgcagggt 1529161 taacgttttc tcctgaaggc cattacctgt tgcgcctgga tcagacccgc catggccagg 1529221 atcaataaaa attttaacca tttttcatca cctcattaca ggatatgaaa aaacacggct 1529281 tctgcttgta cgattatcat tcaactgaaa aatgaggaaa taaccctttc acatccagaa 1529341 attatttctc gggaaagcgc acaattcaac atgaagcgac aacagatacg gtccgacatg 1529401 aaatctgtgc atacgccata tgtttgtatg tactatgggt tcggttaacc tgcactgatt 1529461 cctgctggtt ttaagctttg cgttcatatt aaatcaagca tttaaaacgt aaattgatga 1529521 ggaaagctcc tttcattaaa gacaccgctt tataaatcga aaaaaagaaa aacacttcag 1529581 gtatcttagg gcgggtaata cgtttcgtac aaaaatcagc ccgttgtatg aaaaagaaat 1529641 aatgagaaag aagctcacta taatactctg acaaaatgat taaaaacaaa atctcatggt 1529701 ttgtccaccc catgtccgtg aatacaataa gaaataaagt atttctcggg aaagcgcagg 1529761 attccttatt gttcccgaaa aaagcaattg tttcgacaca tgataggcgt ttgtcacaat 1529821 cggcatccgc ttgaatatca tatagagaga acagagaggt gaagatgttg gagcgcgctg 1529881 tgacttataa aaacaacgga cagatcaaca ttattctgaa cgggcaaaag caggtgctga 1529941 cgaatgctga ggcagaggcg gaatatcagg ctgcattgca aaaaaacgaa gcaaagcacg 1530001 gcattttgaa ggaaatcgaa aaagagatga gcgcattagt tgggatggag gaaatgaaac 1530061 gcaacatcaa ggaaatatac gcctggattt ttgtgaacca aaaacgcgcg gagcaaggct 1530121 tgaaggttgg aaagcaagcg ctgcacatga tgtttaaagg aaatccggga acgggaaaaa 1530181 cgacggttgc acggctcatc ggcaagctgt tctttgaaat gaatgtcctg tcaaaaggcc 1530241 acttaataga agcggagcgg gctgacctgg tcggggagta tatcggacac accgcccaaa 1530301 agacgagaga tttaatcaaa aagtcattag gtggcatttt gtttatagac gaagcctact 1530361 cgctggcaag aggcggcgaa aaggactttg ggaaagaagc gatcgacaca cttgtaaagc 1530421 atatggaaga caaacagcat gagtttattt tgatactcgc cggatattca cgggaaatgg 1530481 atcattttct ctcgttaaat cccggactcc aatcaagatt tcccatctcc attgattttc 1530541 cggattactc tgtgacccag ctcatggaga ttgcgaaacg aatgatcgat gaaagggaat 1530601 accagctcag tcaagaagcg gaatggaaat tgaaagatta cttaatgaca gtgaaaagca 1530661 cgacaagtcc cattaaattc agcaatggac gttttgtcag aaatgtgatc gaaaaatcga 1530721 tcagagcaca agccatgagg cttttaatgg gagaccaata cttaaaaagc gacttgatga 1530781 ccatcaaaag ccaagatctt tccattaaag aagaagcatc tggatctgca tagacctctc 1530841 agtttttgag aggtctgttt tttgctcgta tttccgcttt tcaaagcaat cgatttgtgg 1530901 tatacacatg cagggtttgg tatgataata ctactgccca atatgcaaaa gaaaggaaca 1530961 tccatttgaa cgaacaagaa acgattcagg agaaagccat tttagtcgga tgtcagctgc 1531021 cgcatatcac ggatgagcat tttgaaaatt ctatggaaga gctagcatct ctgacgaaaa 1531081 cagcagacgg aaaagtactg accagcgtca cacaaaaacg gaacagggct gacgccgcta 1531141 catatatagg aaaagggaag gtagaagagc tgaaggcact cgtggaagag cttgaagctg 1531201 atctcctcat ctttaatgat gaactgtcgc caagtcagct gaagtcattg gcaacagcaa 1531261 ttgaagtgaa gatgattgac cgcacgcaat tgatattaga tatttttgca aagcgggcga 1531321 gaacgagaga aggcaaactt caaattgagc tggctcagct gcaatatgca ctgccgcgtc 1531381 tgacgggaca agggatcaac ctttcccggc aaggcggagg aattggggca agaggtcccg 1531441 gggaaacgaa actggaaacc gaccgccgcc atatcagaaa tcgcattcat gaaatcaaca 1531501 cacagctttc cactgtcatt cgccatagaa gccgataccg tgaaagaaga aagaaaaacg 1531561 gtgtgcttca aattgcgctt gtcggctata caaacgcagg gaaatcaaca tggttcaacc 1531621 gcctgacgag tgctgacagc tatgaagaag acctcctgtt tgccacgctg gacccgatga 1531681 ccagaaaaat ggtcctgcca agcggctaca gtgttcttct ttcagataca gtaggattta 1531741 ttcaggatct tccgacgaca ttgattgctg cattccgctc aacgcttgag gaagtaaaag 1531801 aagcggattt aattctgcat ttaattgatt cttcaaatga ggattatgcg ggacatgaaa 1531861 aaacagtgct tcggctgctt gaggagcttg aagcagatga tatcccgatg ctgacggctt 1531921 acaataaacg tgatcaaaaa ctgcctgatt ttataccgac cgccggaagg gatcacatta 1531981 tggtcagtgc gaaatttgag gacgacgctg cagcctttaa agaagcgatt cagcgctatt 1532041 tgcgccaaga actgttaacg tcttttgaag cacatgtgcc ggcaagtgaa gggaagctcc 1532101 tttccagaat caaatcggaa acgatggtag accgcttcta ttttaatgaa gaaaatgaac 1532161 agtatgacat atccggctat gtccaagaag agcaaagtat catcggtgaa ttaaagaagt 1532221 atatgtagga aggaaatata aagacatgtt tgacacatta acacacggag aattattgaa 1532281 gaaaacggca atggaagtgg aagcggacat tgccggcatt cataaacaaa tagaagaaat 1532341 cagcgagcga aatgagtgga gagtgcttca aagctataga aaacacaaag taagcgacac 1532401 tcatttcacg ccgtctactg gatacggcta tgatgatatc ggaagagaca cgcttgaaag 1532461 catatatgcg gatgtgtttg gcggagaagc ggggcttgta aggccgcaaa tcatttcagg 1532521 cacacatgcc atctcaattg ctttgttcgg tgtcctcaga ccgggggacg agctccttta 1532581 tatcacgggc aagccgtatg atacgctaga ggaaattgtg ggcgtcaggg gtggagaaaa 1532641 cgctggttcg ttaaaggatt ttcaaatcgg ctataatgcg gttgatctga cgaaagacgg 1532701 aaagatagac tatgatgcag tcgccgctgc gatcaatccg aagacaaaag taatcggcat 1532761 tcagcgctca aaaggatatg cgaatcgccc ttctttctta attagtgaaa taaaagaaat 1532821 gatccgtttt gtaaaagaaa tcaatgaaaa tctgatcgtc tttgtggaca actgttacgg 1532881 agaatttgtg gaagagcttg agccttgcca tgtcggagcc gacctgatgg cgggatctct 1532941 cattaaaaat cccggcggcg gccttgcgaa aacaggcggc tacctcgtcg gaaaagcgaa 1533001 atggattgaa gcttgctcat accgtatgac gtcacccggc atcggcagag aagcgggggc 1533061 atctctttac tcgctccaag aaatgtacca aggcttcttt ttggcgcctc acgttgtgtc 1533121 tcaaagttta aagggagcgg tgtttacagc gagattcctt gaaaaactcg gcttcacttc 1533181 aaacccgaaa tgggatgcga aaagaacgga tttaatacaa tccgttgagt tttctgacag 1533241 agaaaagatg attgcttttt gccaggctat tcaatttgca tcgccaatca atgctcatgt 1533301 gacgccttat ccagcctaca tgcctggata cgaggatgat gtcattatgg cagcagggac 1533361 gtttattcaa ggagcaagca tcgaattatc agctgatggc cctatccgcc cgccgtatgt 1533421 agcgtatgtt cagggaggat taacctattc gcatgtgaag aatgccatat gcagtgcagt 1533481 ggattcattg atgcaaaagc aattaattta aattttttaa aaatttctct ggatttgatg 1533541 ttaagaatcc ttacatcgta ttgacacata atataacatc acctataatg aaactaagtt 1533601 aagaaaagga ggaaattgag atgagtgata atattcgccg ctcaatgcct ttatttccaa 1533661 taggaattgt catgcagtta actgagttat cagcaagaca aattcgatat tatgaggaaa 1533721 atggactgat atttccagcc agaagtgaag gaaatagacg attattttca tttcatgatg 1533781 tagataaact gttagaaatc aagcacctga tagaacaagg tgtaaacatg gcaggaatta 1533841 aacagattct ggcgaaagcc gaagccgagc cagaacaaaa acaaaacgag aagacgaaaa 1533901 aaccaatgaa acatgatctg tccgatgacg aactgagaca gctcctgaaa aacgagctca 1533961 tgcaagccgg ccgttttcaa agagggaata cattccgtca aggcgacatg tcccgcttct 1534021 ttcattaatc cgttagcaac tgttttgcta tatacattta ccttttaaga ggaggaattt 1534081 taccaaatgg caaagtacac tagagaagat atcgaaaaat tagtaaaaga agaaaacgtg 1534141 aagtatatcc gccttcaatt tactgacatt cttggaacaa tcaagaatgt tgagattcct 1534201 gtaagccagc ttggaaaagc gcttgataat aaagtcatgt ttgacggttc ttctattgag 1534261 ggattcgttc gtatcgaaga gtcagacatg tacctgtatc cagatctaaa tacatttgtt 1534321 atcttcccat ggacagctga aaaaggtaaa gtagcacgtt tcatctgtga tatttacaat 1534381 ccggatggca caccttttga aggtgacccg cgaaacaact taaaacggat tctgaaagaa 1534441 atggaagacc tcggcttcag tgattttaac cttgggcctg agcctgaatt cttcttattc 1534501 aaattggacg aaaaaggcga gccgacgctt gaactaaacg acaaaggcgg atatttcgac 1534561 ttagctccaa ctgatttagg agaaaactgc cgccgcgata tcgtacttga gcttgaagag 1534621 atgggctttg aaatcgaagc gtctcaccac gaagtagcac ctggtcagca cgaaatcgac 1534681 tttaaatatg ctggagcagt ccgctcttgt gatgacatcc aaacatttaa actagttgtc 1534741 aaaacaattg cccgtaaaca cggcctgcat gcgacattta tgccaaaacc attgttcggt 1534801 gtaaacggtt caggtatgca ctgcaatcta tcactcttca aaaatggtgt taacgcattc 1534861 tttgacgaaa acgcagatct tcagttaagt gaaacagcga agcacttcat tgcaggtatc 1534921 gtgaagcacg caacaagctt tacagcagta acaaacccga cagtaaactc ttacaaacgt 1534981 cttgttcctg gctatgaagc accttgttat gtagcatgga gcgcgcaaaa cagaagcccg 1535041 cttatccgta tcccggcttc tcgcggcatc agcacacgtg ttgaagtacg cagtgtagac 1535101 ccagctgcaa acccatacct tgcacttagc gtattgcttg ctgcaggatt agacggaatc 1535161 aaaaacaaac tggaagcgcc ggctccaatc gaccgcaaca tctatgtgat gagcaaagaa 1535221 gagcgcatgg aaaacggaat cgttgacctt ccagcaacac ttgcggaagc actagaagaa 1535281 ttcaaatcaa acgaagtcat ggtcaaagcg ctgggcgagc acctattcga acacttcatc 1535341 gaagcaaaag aaatcgaatg ggatatgttc cgcacgcaag tacatccttg ggaacgcgaa 1535401 cagtatatgt ctcagtatta atatctcaat cccttggcac taaaagtgtc aggggatttt 1535461 ttatgttaat aggtaataaa ttatggagcg gcatagtgtt taacacagcc attaatcctc 1535521 agacagtcaa atagccattt ctactccggt tgaaagcttc tctatttttg cttcttattt 1535581 atctttcctg tattgatata tgtatgtagg gttggactta taacataaac tattctggcc 1535641 attccgttct ttcaattcat gaccgggctt gccatcagca taaatctagg ctaacagtct 1535701 ccatacatcc tgtgatcacc tttatcaaac tcttaaatgc aacttaccac taaccaattc 1535761 tttatttcgc atagatcatc tttgtcatgt gtttacacaa gaatctgttt tggactgaga 1535821 cactgaatat aacaaaacag tcaaaaatca atatttaatt cattctgttt aaactttctg 1535881 aaaaagatgt tgaaaaagtc gaaaggattt tataatatta agtcaagtta gtttgtttga 1535941 tcaacaaact aatgaaatga actttcatta tccacaagat aagatcttac taatatggat 1536001 ggaaggggga taagagggtc gatttaatgg agctaaacaa tataagaaac gaaagaatga 1536061 ggcttttatc cttttccagg tatataaggt atgacgaaaa aagatgaatt ttttgcttgc 1536121 tgatcaccat atttttttgc actgttttga aagcgctttt ataaaagttt actgaccgta 1536181 aattcgagaa attgttatac cgtttcacac tgttccatat taaaggatcg aaaaggggag 1536241 aaatcatgct cagtgaaaat gtaaagaaga ttagcatggt tgaaaaagtt ggatatgcgt 1536301 ctggagattt tgcttgtaat ttaatttatg caacagtgtc tacgtatctt ttgttcttct 1536361 atacagatgt ttttggttta tcggcagcag cagccggtac tatgttttta gtggttagaa 1536421 taatcgacgc tctcgctgat ccttttatcg gaacaatagt tgacagaacg aacagcagat 1536481 ttggacgctt tagaccgtat cttttattcg gagcttttcc atttgtcata ctggcaatac 1536541 tctgttttac aacaccagac ttttcggata tggggaaatt aatatatgcc tatataacct 1536601 atgttggctt gtcgcttaca tacacaacga taaacgttcc atatggcgcg ttaacttctg 1536661 caatgactag aaataatcaa gaagttgtta gtataacttc tgttcgcatg ttatttgcga 1536721 atcttggggg acttgtcgtt gcattttttg ttcccttact ggctgcttat ttaagcgata 1536781 cttccggcaa cgagtctctt ggctggcaac taaccatggg tattttggga atgataggcg 1536841 ggtgcctttt aatcttttgt tttaaaagca caaaagagcg ggtcactctt caaaaatccg 1536901 aagagaaaat taaatttacg gatatatttg agcagtttcg tgttaatcgt ccacttgttg 1536961 tattaagtat tttctttatt attatttttg gagtgaattc catcagtaat tcggttggca 1537021 tttactacgt aacgtataac ttagaaagag aggatttggt gaagtggtac ggtttgatag 1537081 gaagtttacc cgctttggtc attttaccgt ttattccaag gcttcatcaa tttttgggga 1537141 aaaagaaatt actaaactat gcattattac tgaatattat aggcctctta gctttactgt 1537201 ttgttccgcc aagtaatgtt tacctcatac ttgtctgtcg attaatcgct gctgctggaa 1537261 gtctcactgc cgggggatat atgtgggcgc ttattcctga aacaattgaa tatggagagt 1537321 acaggactgg gaaaagaatg ggtgggctca tttacgctat aatcggattt ttctttaagt 1537381 ttggtatggc cttaggagga gttgttccgg gtctggttct tgataagttt ggatatgtag 1537441 caaatcaggc acaaaccccg gcggccttaa tggggatttt aattacaaca accattattc 1537501 ccgtgttctt gcttgttcta gctttaattg atattaattt ctataactta gatgagaaaa 1537561 aatataaaaa catggttcga gaattagaga atagagacaa agtttatttg gatcatattg 1537621 atgatttcaa ggcttaaaaa agaaaataaa ctgaggagga gtcccaaatg aagattacca 1537681 atcccgtact taaaggattc aatcccgatc caagtatttg tagagcagga gaggattatt 1537741 atatcgctgt atctacattt gagtggtttc cgggagtcca gatacaccac tcaaaagatt 1537801 tagtaaattg gcacttagtt gcacatccat tacagagagt ttcacaatta gacatgaaag 1537861 gaaacccaaa ttcaggtgga gtttgggcac catgtttaag ctatagtgat gggaagtttt 1537921 ggctgatcta tacggatgtt aaggtagtag atggcgcatg gaaagattgt cacaattatt 1537981 tagttacttg tgaaacgatt aatggtgatt ggagtgagcc gattaaatta aatagctcgg 1538041 ggtttgatgc ttctttgttc catgatacgg atggaaaaaa gtatttatta aatatgttat 1538101 gggatcaccg tattgatcgg cactcatttg gaggaattgt tatacaggaa tattctgata 1538161 aagagcaaaa attaatcggt aaaccaaaag ttatatttga aggaactgat agaaaactga 1538221 cagaagctcc gcatctttat catatcggga actattatta tttattaact gcagaaggag 1538281 gaacacggta cgaacatgct gctacaattg ctcgttctgc aaatattgag gggccatatg 1538341 aagttcatcc cgataatcca attttaacgt catggcatga cccaggaaat ccattgcaaa 1538401 aatgtggtca tgcatccatt gttcaaacac atacagatga gtggtattta gctcatttaa 1538461 cgggacgtcc tattcatcct gacgatgatt caatttttca gcagagagga tactgtcctt 1538521 tgggcagaga aacagctatt caaaaacttt actggaaaga tgaatggccc tatgtagtag 1538581 gtggaaaaga aggaagcttg gaggtagatg caccttctat acccgaaaca atatttgaag 1538641 caacgtaccc ggaagttgat gaatttgagg attcaacatt aaatataaat tttcaaactt 1538701 taaggattcc attcacgaat gaattaggtt cattgactca agcgccaaat catttacgat 1538761 tattcggtca tgaatcattg acctcgacat ttactcaggc atttgtagcc agacgctggc 1538821 aaagtctcca ttttgaagcc gaaactgctg ttgagtttta tccggaaaat tttcaacaag 1538881 ccgctgggtt ggtgaattac tacaatacag agaactggac ggctcttcaa gtcacgcatg 1538941 atgaagaact tgggcgcatt cttgaattaa caatatgtga caacttttct ttttcacagc 1539001 cattaaataa taaaattgtt attcctcgtg aagtaaagta tgtatattta agagtaaata 1539061 ttgaaaagga caaatattat tatttctatt cttttaacaa agaagattgg cacaaaattg 1539121 acattgcact ggaatcgaaa aaattatcag atgattatat ccgtggggga ggattcttca 1539181 caggggcctt tgtagggatg caatgccaag ataccagtgg taatcatatt ccggccgact 1539241 ttagatattt tcgttataaa gaaaaataat ttgcacatga aaaaggagat ttctatttta 1539301 gaactccttt ttcatatgag aaggtgccat gtcactattg cttcagaaat actcctagaa 1539361 taaaaaaact catctttaaa gatgagctgt ccattccata aaaaattaca ttgtaatcat 1539421 gtccagaaaa tgatcaatca caatggagga cattcctaat gccggtgcat tctgtcctaa 1539481 ggaagatggc aataattcat agctattgcc taattgggaa taaacccttg atgatacttc 1539541 acttctcatt gaatttaaaa ccataggatg cgattcaatt atgctatttc ttaaaattac 1539601 ggcttgtggg ttgaaagtat ttagaatatt ggtaaggcct attcctaaat agaatccaaa 1539661 attttgtaat gcatttaagg ttccgatatc attcagatgg gcgaggttta tgatatcttg 1539721 ataggacagt tttttctctt tggtctgaag agattttaat aaagccttct ctgaagcata 1539781 caattcccag catcctcggt ttccgcaact gcatttagga ccattaaagt ctattgtcat 1539841 atgtcccatt tctccagaga agccgcttac tcctctatat aaatgattgt tgataataac 1539901 accgatccct attcctgtgc tgatacttac gtaaataatg ttatcgtgat tttttgcagc 1539961 tccaaatact ttttctccat atgcgccagc atttgcctca ttttcaataa aaacaggcac 1540021 attgtacttc tcttgtatcg aagattttaa gtcaatatct ctccagttgg agttcggagt 1540081 gaaaacaatt ttttgatctt tatcaatgag tccaggcacg caaataccta taccaataag 1540141 cccgtacgga gattggggca tttgcgtaat aaagtgatga atcatatcaa tcaaaatgtc 1540201 tttcgttatt tctggagaat tggattccaa atggcggtat tgatcaagaa cgattgttcc 1540261 ttcaaggtct gttaaaatgc cattaatata atccacacca acatctattc caacggagta 1540321 tcctgccttt ttattaaaaa caagcatgac aggtcttctt ccgccacttg attgtccttg 1540381 acctatttca aataccatac tttctttcat taacgtgttt acctgtgatg agacagttga 1540441 tttatttaat ccagtcattt cagataattt tgctcttgaa ataggtgaat ttttaaggat 1540501 ttcttttaat aataactttt gatttacttt tttgacaaag gtttgatcag cgatatccac 1540561 ttcatccact ccatttgttt aatctttaaa ttaagtatca acatagtaca tagcgaatct 1540621 tccctttatt atatctaatg tgttcataaa aaactaaaaa aaatattgaa aatactgacg 1540681 aggttatata agatgaaaat aagttagttt gtttaaacaa caaactaata ggtgatgtac 1540741 ttactatatg aaataaaatg catctgtatt tgaatgaatt tatttttaag ggggaaatca 1540801 catggctcaa tctcattcca gttcaatcaa ctattttgga agcgcaaaca aagtggttta 1540861 cgaagggaaa gattcgacta atcctttagc atttaaatat tataatcctc aagaagtaat 1540921 cggcggaaaa acgctgaaag agcatttgcg attttctatt gcctattggc atacatttac 1540981 tgctgatggt acagacgttt ttggagcagc tacgatgcaa agaccatggg atcactataa 1541041 aggcatggat ctagcgaaga tgagagtaga agcagcattt gagatgtttg aaaaactaga 1541101 tgcaccattc tttgcttttc atgaccggga tattgcacca gaaggcagta cgctaaaaga 1541161 gacaaaccaa aatttagata tgatcatggg catgattaaa gattacatga gaaatagcgg 1541221 cgttaagcta ttatggaata cagcaaacat gtttacgaat ccccgtttcg tccatggtgc 1541281 cgcgacttct tgcaatgcag atgtgtttgc gtatgctgca gcacaagtga aaaaagggtt 1541341 agaaacagca aaagagcttg gcgctgagaa ctatgtattt tggggcggcc gtgaaggata 1541401 tgaaacattg ttaaataccg atttaaaatt tgagcttgat aatttggcta gatttatgca 1541461 tatggcagtg gattatgcga aggaaatcgg gtacacaggg cagtttttga ttgagccaaa 1541521 accaaaagag ccgaccaccc atcaatacga tacagatgca gcaacaacca ttgccttttt 1541581 gaagcaatat ggcttagaca atcattttaa attaaatctt gaagccaatc atgccacatt 1541641 agccgggcat acattcgaac atgaattacg catggcaaga gtacatggtc tgcttggctc 1541701 tgttgacgca aaccagggtc atcctctttt aggctgggac acggatgaat ttccgacgga 1541761 tttatattct acgacattag caatgtacga aatcctgcaa aatggcggcc ttggaagcgg 1541821 cggattaaac tttgacgcga aggtcagaag atcttctttc gagcctgatg atctaatata 1541881 tgcccatatt gcagggatgg atgcatttgc aagaggattg aaagttgccc acaaattaat 1541941 cgaagatcgt gtgtttgaag atgtgattca acatcgttac cgcagcttta ctgaagggat 1542001 tggtcttgaa attatagaag gaagagctaa tttccacaca cttgagcaat atgcgctaaa 1542061 tcataaatca attaaaaacg aatctggaag acaggagaaa ttaaaagcga tattgaacca 1542121 atacatttta gaagtataac aggataagct ccagatcctg ctatcaatac caagtcactg 1542181 aattacccgt catgattcct ttcctattgc ttgttgttat gacgggtaac ttctataatt 1542241 aggatttatt tagagtgaat ggttttttaa aagggcaagg agtgaaaaaa tgaagtatgt 1542301 cattggaata gatcttggaa cgagtgctgt taaaaccatt ttagttaacc aaaacggcaa 1542361 ggtttgtgca gaaacgtcca aaaggtatcc gctcatccaa gagaaggcgg gatatagtga 1542421 gcaaaatcct gaagactggg ttcagcaaac aattgaagca ttggctgaat tggtttctat 1542481 atccaatgtt caagccaagg atattgacgg gataagctat tcgggacaaa tgcatggatt 1542541 agtactgctt gaccaagatc gtcaggtgtt acgtaatgca attctttgga atgataccag 1542601 aacaacgcct caatgtataa ggatgaccga gaaatttggc gatcatcttc ttgacatcac 1542661 aaaaaaccgt gttttagaag ggtttacatt acctaaaatg ttatgggtaa aggaacatga 1542721 acctgaactt tttaaaaaaa ctgctgtgtt tttgcttccg aaagactacg tgcgattccg 1542781 tatgaccggt gtcattcaca ccgaatactc cgatgcagca ggaactttac ttttacatat 1542841 tactcgcaag gagtggagca atgatatttg caatcaaatt ggtatttctg cagatatttg 1542901 tcctccgctt gttgaatctc atgattgtgt aggatcgctg cttccgcacg ttgccgcgaa 1542961 gaccgggcta ttagaaaaaa caaaagtgta cgctggggga gcagataatg cttgcggcgc 1543021 tattggagca ggtatccttt cttccggaaa aacattatgc agtattggga cgtcaggggt 1543081 catactttcc tacgaagaag aaaaagaaag agactttaaa gggaaagtcc acttttttaa 1543141 tcatggaaaa aaggattctt tttatacgat gggcgtcacg ctcgctgcag gatacagctt 1543201 ggactggttt aaaagaacgt ttgcaccaaa cgaatcgttt gagcaattat tgcagggggt 1543261 ggaagctatt ccgataggag ccaatggact gctatacact ccttatttgg ttggtgaaag 1543321 aacgccgcat gctgattctt ctattcgggg aagcttgatc ggaatggatg gagcccataa 1543381 tagaaagcat tttttgaggg caataatgga aggtatcaca ttctctttac atgaatcaat 1543441 tgagctattc cgcgaagcgg gaaaatcagt tcatactgtt gtttctattg gtgggggagc 1543501 taaaaatgat acgtggctgc aaatgcaagc tgatattttc aatacgaggg taattaagtt 1543561 agaaaatgaa caagggccag ctatgggggc tgcaatgctg gctgcctttg gaagcggttg 1543621 gtttgaatca cttgaagaat gtgcagagca gttcattcgt gaggctgctg cattttatcc 1543681 aaaggcgcaa aatgttcaaa aatataaaac actatttgat ttgtataaga acatttacac 1543741 tcacacaaag gatctcaata cagctttgaa gagctttcga aaaaactaat gatgttattg 1543801 tctggagatc aaccgaagaa caattaatga tcaatcatca tcaaaggcct ttgataacat 1543861 ggctgccttc ttttgaaaag atggtgagaa taaggtatcg caacctttaa acagtattgg 1543921 agtatccagc agacaaaacg aacgagtgga accgtatttt gtcagcgaac acttcaagaa 1543981 gtggggaagc ttaggaatgc caatgggtaa gatgtatgaa accgcgctaa cgacggtaga 1544041 gggatctctt gatttatgaa gaaataggaa ggatgttaac acacaaataa cccctcacat 1544101 tgacgtgaag gggtgttttt tattgttact atacagcgga aattttacag gctagttgca 1544161 tgattttagc ttgttaagca gaatggaact agactctcca tcatctcttt ctcattcttt 1544221 ggaaactgca ttctgctagg tttgctgctt tttttaacaa acagtgtttt tctatttcac 1544281 acagccatta aatcctctgt tcgtcacata accgctctta ctccaaattg acagtttatc 1544341 tgattttgct tcttgctcat ctagtctgaa ttggtctatg tattttgtgt taggctcata 1544401 tacatatgct actctggcca atccctcttt caataatgtc tcttgaacag atttgccgtc 1544461 aacataaacg tatgctaaca gtcttccata cttatctctg cgatcgcctt tatcaaattc 1544521 cagctgtagc ttaccgctgt tgaccaattc tttatttcgt ttcgacgcat cctcaccgta 1544581 tggttgaaca caagaatttg gtttcttcgt ctcaggtgta tcaacgagca agtagcgaac 1544641 tgtgtctttc tttccgttgt aaataacctt aatcgtatct ccatctattg ctctatctaa 1544701 tgtaacattg accaatttct tctgattttt tgaatgaggc gtgccagcct tttgttctgt 1544761 ctgattatat tcattagagt gagtatcttg agagacttgc tccgtcccat tagaatctga 1544821 atggtttttg gctgcgtgat ttgatccgca agctgccaaa gtaatactta aaacgattgc 1544881 gatcatactg atcaaaatct tcttcatatt gattccctct ttatcatttt ctcttttcgc 1544941 gattaaacat catcattata acgatatgga cattttttgt gaatggaaaa cttcaaggga 1545001 acttataaca ctccaaattg ccaatagtta acttcacaac gagatgatca aaacatcacc 1545061 atcacatagc ggaaataaat aatcctgaaa ataatattga ctgaaaatgc ttttagaatt 1545121 atgataatat gagaaatgac aataatgtga caaagacatt actacaacat aacaactaat 1545181 agcttaggtt tattctattg gttaaaaatg taaacggtta caaatccaga ggcgaaaatc 1545241 taagatagag atgactttag ttttgactca atatccacac tgaaagagct tattaagtat 1545301 tcttaaaggc aggggaaatg gatatgaatg aacatcgaaa tcgaaggttg aaattaataa 1545361 tgatttcagc aacttttgga gggcttctct ttggatatga caccggagtt ataaatggag 1545421 ctttaccttt tatggcaagg ccagatcagc ttgatttaac acctgttaca gaagggcttg 1545481 ttacgagtat tcttttatta ggtgccgcgt ttggagcgtt gttatgcgga agattggctg 1545541 atcgatatgg ccgccgtaaa atgatcctta atctttcctt tttatttttc ctggcatcac 1545601 tgggaacagc gttagcacct aatgttttca tcatggcggt ctttcgtttt ttactggggc 1545661 tggctgttgg aggagcctcg gcgatggtgc cggccttttt agcagaaatg gcaccgcatg 1545721 aaaagagagg gcgtatggta acccaaaatg aactaatgat tgttggcggg caatttttag 1545781 catatgtttt taatgcgatc ctcggtgtaa caatggcaaa tacgggacat gtttggagat 1545841 acatgctagt catttgtgct gtaccggcta tcatgttatt tgccagtatg cttaaggtac 1545901 cagaaagccc ccgatggcta atctccaaag gcaaaaacag tgaggcgctg cgagttctta 1545961 aacaaattcg agaagataaa cgtgcagaag ctgaatgtag agaaattcaa gaagcggtag 1546021 aaaaagatac agcactagaa aaggcatcac tcaaggactt ttctacacca tggctgcgcc 1546081 gtcttttatg gattggaatc ggtgttgcca tcgtgaatca aattacaggt gtgaactcga 1546141 ttatgtatta tggcacacaa atccttaaag aatctggttt tggtacaaaa gcggctttaa 1546201 tcgctaatat tggaaatggg ctgatatcag ttattgcagt tatatttggg atttggctgg 1546261 tcggaaaagt gagacggcgt ccaatattat tgattggttt ggcagggacg actacagcgc 1546321 tcctattgat tgcgattttc tcaattgtgc ttgatggatc tatggcactt ccttatgtag 1546381 tgctttcttt gaccgtttta tttcttgcct ttatgcaagg gtgtgtagga cctgtgactt 1546441 ggcttgtcat agcggaaata ttccctcaaa ggttaagagg acttggttct gggataagtg 1546501 tttttttcct ttggatatta aactttgtga tcggttttgc tttcccgatc ttgcttagct 1546561 ctgtaggttt gtcttttaca ttctttatat ttgtggcttt aggtgtattg gcaatcggtt 1546621 ttgtgtacaa attcatgccg gaaacaaaag ggcgtacact tgaagaatta gaagagcatt 1546681 ttcgttctcg acacgatcat aatactcctg aacaatcagt tattgaggta taaatatgtt 1546741 gaaaatctct cttcttatag gagggatttt tttagtttca gaaaaaacaa aatccctctg 1546801 gtagagggat tttgattcag cattttaaga tgttctacac gtataatact ggagttgata 1546861 ctttaaaaat ctcgccatct cttatataaa aacgagggat gcggcggctt aatgtagaca 1546921 cgacttcata gttaatcgta ttgagcattt cagccacttc atcaacggaa atctcggctc 1546981 ctttttgctt accgtaaatc acgacttcat ctccttgttt accttcaccg ttttctccta 1547041 aactgaccat gatcatatcc attgttactc ttcccgccac tggcactcgt tttccgcgat 1547101 gaagaacaaa cccgcgattg gaaagggcac gagaatagcc gtcagcatag ccaatcggga 1547161 gtgtagcaat tacttcatta ggttctgcga tgtatgtagc accatagcta acggttcggg 1547221 gttctgtccg catggttttc acataagcga tgcgtgcctt taaacttaac gcaggttcaa 1547281 gcttaacgag atttagttgt ttaatatagg ctgaaggata taaaccatat aagccgatac 1547341 ctaaacggat catatcagcg ctaaattccg gaaatgcgat agctgcagcc gtgttgcaca 1547401 tatgcacggt gggcagctca atcccctgtt tttttaaaaa gctgagaaaa ctgatgaatt 1547461 tttcatgctg cagctttgtg agtgttgtgt ccggttcatc agctgtcgaa aaatgtgtga 1547521 aaatccctgt ccatctgagg aatttacttg cctttaaggc tttcactacc tctaaaagtt 1547581 cttcctttgt gcgtacacct aatcgtccca tgccggtatc cacgttaata tgaatggcca 1547641 gccggttagc actcgcttct ttttccaata tctcgtttgc ttctttcatc caatcaacct 1547701 gaaatgctga taatgttata ttccaagctg ctgacttctt tacacaacta agggatgtaa 1547761 aaccaagcac aaggataggt gctgtaatcc cagctttacg taaaacgatt ccttcctcca 1547821 cactggcaac agcgagctca ctcgccccgt gttccagtgc atggcgtgcc acttctatag 1547881 acccgtggcc ataaccgttc gcttttacaa cagccataat tttgctctta tgtggaatat 1547941 gacggcggat cgctcgcaaa ttctttttaa cggcatcaag attgacttcg atccaaactt 1548001 ctcggcaaag ctttatcatc aacgcttcct tccttcttat ggattataaa taccacctat 1548061 tgccgcaaga ataaatgtta attgttggat gattcgatct tattttattc aactttattt 1548121 gaaatcattc aacagcaaat ccatgtgata cgagaaggtg cctatcaatg ttcgaataat 1548181 agcaagtacg ggatacatga ggcttgtaag tggggtgtta atggatgcgg cgaccgagga 1548241 ttacaaaaat gattatttgt tttgggacat ttttttctaa gggtagatga taacgagaaa 1548301 tctaatcagg aaatacttac cgttgttatg aacattgaag aaccttttaa atgagaaggg 1548361 ctgaggaaat tctgtaaaag ataatcggtt gaaaaggcag tcgattcctt gttccataaa 1548421 cctaacatca gagtatataa ttatactcgt attcacaaaa atcgtttaag taaggggtat 1548481 acatgaatag gggagttagt tttcaaatac cgaatgaata tggaaatttt ctatggagaa 1548541 tactgcagcc ggtagaaata gctaattata ggtggcaaac gagtggggaa tcttattttg 1548601 ttgtagaagg agagctcgat gatgaggagc tttttcatga ctacgaaatt gttgaggggg 1548661 cagtttttga gcaacaatta aaaacgaatc agtactatac cattttcgtt gaactgaaag 1548721 catttccata tggaaaaatg gttaatcaag tcaatacata tgaagagttt gctgacagtg 1548781 attgcgaact tgtccttttg atagcagata atagctacgt ttcgatttac tgtaaaaaca 1548841 aaaatatcat tgaaaaactt tacttcaatg ctttacagca tgattttgaa gacgttcaat 1548901 ttataactga tgaaaatgac acaagaacaa gccttactgt atgatactca ataaaaatta 1548961 aaggagctag tacatgacaa tgcaaattaa aatcaagtat ctagatgaaa cacaaacaag 1549021 aatcagcaaa attgagcagg gagactggat tgatcttcgg gcagctgaag atgtaacaat 1549081 caaaaaagat gaatttaagc ttgtcccatt aggtgttgca atggagctgc ctgaaggtta 1549141 cgaagcacat gtcgtccctc gttcaagtac atataagaac tttggcgtta ttcaaacaaa 1549201 ttcaatgggt gttatcgatg agtcatataa gggagacaac gatttctggt tctttcctgc 1549261 ttatgcattg cgtgatactg aaattaagaa gggtgatcgt atctgccagt ttagaatcat 1549321 gaagaaaatg ccggcggttg aattggttga agtcgagcat ttgggaaacg aggatagagg 1549381 aggactcggt tcaacaggta cgaagtaaac aaaataaatc cttggctgtc ttcatgctgt 1549441 gtgattgatc aatggaggtt tcagccaagg tacatataaa tattatgtat aaaatgaata 1549501 ttttaatacg aaggatttaa ttaaaaacaa agtttaaaaa gggaagtttt gaaaaagtga 1549561 aatagtaata actaaagtcg ataaagaacc taaagatgtc aaagaaacaa tttttctggt 1549621 gctttgcttt tttgaaggtt tacttagctc gtggataact gccccccata aaagcatgga 1549681 tgctaaaatt ataatactta tatacataaa gatgctcctt ttattatatt tacagttttt 1549741 acatttttat cgattttacc acatttagga ttgagttgtc gatgaaacaa gcatctctat 1549801 aaagaaatac ttttatctaa atttttataa ataggggaag gcaactaaaa actagtaatg 1549861 ccactaataa taagccaagt taaatgactt gtgttcatta ataattgaat tttacagcag 1549921 ccatgagcac aaaaaaatct gagttcgtcg ataaatatca taaaaaagcc cccggtatgt 1549981 cgccagggaa taaatagacg tttaagagat ttagtgatgt tttttatatg attcgacaaa 1550041 atcataataa tgatcatcgt catcataata ctttttttcg taatgataat cgtgatcatc 1550101 gtaatacttt ttatcatggt catcatactt tttgtcgtaa tcataatgtt ttttatcatg 1550161 atcataatac ttgtcgcaat cataatgctt cttatcattg tcgtaatact ttttgtaata 1550221 tgtttttttc caagtataat actcttcttt atatttttta taataaccca attaaattcc 1550281 tcctttatgt tattcgaatt taatttatga agtttaaatg atatggtatg gtcaaatgaa 1550341 ataagaatag taaaaagagg ctgtttaaaa cactttctga aaaacaaaac ggatagctgt 1550401 ttatgaaaat aagagcgaga gagagcactc aatcactgta aaataatagt aaagtgtata 1550461 gagagattag tatacgtaaa aagggacttt ctcattgaag aatatttgaa cgttatggtt 1550521 aagattcaag agctctatga tgtgattttt cacactgctt ttgaaggatt tagagttaga 1550581 catcaaaaac aaacagcaaa accggctaga aacagatcat ataaggaatg aaccgctgcc 1550641 aaatatcata aaaaagttgt taatgatcaa atgaatgaaa ttagagagaa tttattttaa 1550701 agaaagccca attgcacatg gacaaatgac aattgatatt gaggtaaaat acaatgcatt 1550761 aaatcagaaa aagctattgg aggatttaat gtgtttagac aatttccaat ttggtataca 1550821 caaacacctg actatttgaa tttttatgta ccgcaatatc aaaccatttc gtataatcct 1550881 caacaatgtt atcaacggtg tatgtaccaa actggcggta actatgagct atgtgacaga 1550941 ctatgttatg gagaaataca ggtgtaaaag agggggatta actcctcttt aaacacacag 1551001 tgagtggaat aagatcctca ctttatctgc aagtgcttag tatttgcgat aatattgcat 1551061 tcgtaataaa ttatgcttag caactgaaaa tgaaagaagg atatgaatag tcatgacgca 1551121 attcgataaa caatacaatt caattataaa ggatattatc aataatggaa tctcagacga 1551181 agagtttgat gtaagaacca agtgggactc agatggaaca ccggcacata ctctaagtgt 1551241 aatcagtaag caaatgagat tcgacaactc agaggttccg attttaacga caaaaaaggt 1551301 tgcctggaaa acagccatta aagagttgct ctggatttgg cagctgaaat ctaatgatgt 1551361 taatgattta aacatgatgg gcgtccatat ttgggatcag tggaaacaag aagacggaac 1551421 catcggacat gcatatggat ttcagctggg gaagaaaaac agaagtctaa atggagaaaa 1551481 agtggatcag gtagactatc ttcttcatca attgaagaac aatccatctt cacgcagaca 1551541 cattacaatg ctgtggaatc ctgatgaatt agacgcaatg gccttaacgc catgtgtata 1551601 cgagacacaa tggtacgtta aacatgggaa actccacctt gaggtaagag cacggagcaa 1551661 tgatatggca ttgggaaatc cattcaatgt attccagtat aatgtgttgc agcgcatgat 1551721 tgctcaagtg actggttatg agcttggtga atatatcttt aacattgggg attgccatgt 1551781 gtacacacgt catatagaca atttgaaaat tcaaatggaa agagaacagt ttgaagcacc 1551841 tgaactatgg atcaatcctg aagtgaaaga tttttatgac tttaccattg atgatttcaa 1551901 gttaatcaac tataaacatg gggacaagct tttatttgag gtagcggttt aatgctgcct 1551961 ttttattgtg cagtgaatag atagcaggta tcctaatttc attaagcaat ctggaagatg 1552021 aataaaaatt gaaggacaaa cacgtataat acataaaaaa gattaactct acagttaatc 1552081 ttttttattc agaagaaaat atcctaactt tgaaactaaa tacaaagtaa aagcaatcat 1552141 tacagttcta gatattacaa ttccatgaat agctagatca tatccagcag gtatcaacgc 1552201 atttgtatta cacataaaat atatagatat tagaagtgct acaataacta aaatcattcc 1552261 aaaaagactt gttttttcat atttcatacc aatttccacc cttattaaag ttaggtttaa 1552321 acaaaagagc tgaagaaacg aactatgacc agtatgctcc aaggaaaacc gccagacaat 1552381 gctggcggct ttttgctgct tcgtttattt attaacagag atcgtaacgt tatttcctgc 1552441 aactgaaacc tttgcgaaat cctgtgtatc taccacagga gtgacggctt tattgtcgat 1552501 agtgatgttg ttaaaagagg tcgaaaaggt tgctttgatc gcatcacgct ggctttcata 1552561 cgaaacagcc gcggtagcaa gtgttttcca ttttgaaatc gtgccgatgt tggttccttg 1552621 aatttctgtg ataatccgtc cggtgtagcc gtcattgttc gttccccaaa gggtcatgcg 1552681 cgtattgccg cttaaatttt tatagattgt catttggact gtgcttccag ggcggaagcc 1552741 tttattgtat gtgaatttgt cttttccttc gatgtacgtt tcttcatttt tggacccaac 1552801 cttcatgagg ggcttccaga cgttgtattg tttgctgtac tgaagcccga tatcggcttc 1552861 agttccgctt gttgccctaa agccagaata aatataggga gtagagaccg agtcgttgtt 1552921 tttgacagtt tcaggaagca cgattttagc tgtaaaaacg gcgcccgtac tgttcaggta 1552981 gacacggccg ccgattccgt taggcagctc ggatgctgct tttgcgactt gagcgtctgc 1553041 cgcgggtaaa cctggtatac ctgatgaaag ggttccgaaa agaactgctg ttcctactgc 1553101 acctgcaatc aatacttttt tcaccaaaat tccccctttt gatagtggtt tcgccattta 1553161 ttatacctta ttttggaact ggatttacgt atataaatcg acaaaatatt tcattttgaa 1553221 tgatgtaagg tcgaaacgct tcgccaatct gaaagctata tacctttatc agaggaaaga 1553281 atgagatcac attcgtttta accgatttga aattttcctc aaaataaaag tacaaatgct 1553341 taaagaaacg attattaaaa gaatgcccgc tatcgtttcc aagcctgtaa aaaagaggtg 1553401 acgtttcatc aatgtctgtc cttgtaaaat gataaaagca cagataccga ctaagaaaag 1553461 aaaacaaata cttaggattg ctaacgcttt acgtgagtat gttttcattt catctttaaa 1553521 atacagcaat acgaaaataa agcagataac attggctatt gttctaatca cctcaaagct 1553581 tttcatgaca actgatataa atagacaaag taaaatgaga taaaatacga tgtttctata 1553641 caaaaaacct ctccttttat gtaggatcct caaagagttt ataaaagttt ctttgtaact 1553701 gcaataaatt gaatgcgctc acttatgaac taactaaact atgtactaaa tattcactat 1553761 tctttttcag attcagtcac caaggttttc atagaaaggg aagcttcaga aatatacata 1553821 tagtgcacaa acaaaaaaga cccggcaata gccgggggaa agtaaaaacg aggagatgtt 1553881 aatggcgttt agtagtgttt tttatgcttt ttatactcta caacataatc atagtctttt 1553941 ttatcgtgat cataatattt tttatcatag tcatcatatt ttttgtcgta atcacagtca 1554001 taatcttttt tatcatattc gtaatacttc ttataatacg tttttttgac cgtataatac 1554061 tcttctttgt attttttgta ataacccata tatactcctc ctttattttt actacgcttt 1554121 attatacggc gagtagattt tgcggcttgg acagttaaaa tcatagaagg aaaaaagggc 1554181 tgtccaaatg atagaaaaag acagatgaca caaaaacaaa tcaaaataaa gagccgattt 1554241 ttcatcggcc caaacgattt atcctacatt tgtttgtctt ctttgttttc tgagtcattt 1554301 tttctgatat cctgagtcag tccgcttgtt gcttgtttaa attctgataa ggcttttcct 1554361 gctgcacggc caagcgccgg cagtttatca ggcccaaata ctaaaaaacc cacaaacaaa 1554421 ataacgagta tttttgtgaa gcttaattcc atatcctttt ccccctgatt gaagtacaac 1554481 cttttaaaca aattataaga gatagcagta caaatgggaa tgcatttatt ttgaacattt 1554541 taaaaccagc acaaagacgg attcataaaa cggctgctgc tgaatataat gtccaatgcc 1554601 acctgcctaa gaagcaggag gcaggctgga tcaattatgt agctctgccg gaaatgatac 1554661 aaacgtagcg gctatcattg acatagagga gtggtgtagc tgatgagatt cactaaggta 1554721 gttggatttt tgtctgtttt agggttggct gcggtttttc cattaacggc acaagcagaa 1554781 aaagccggaa ctgcgggggc tggagagtgg gataagttgg ggacttacac atatacttac 1554841 tcaagtccga cggtatactc gaccggagga gattttagag tgtgcctttc aggaagcact 1554901 cctttttctg tttcactgca cttatatgag gatgatcccg gtgacaatcc tgatgattat 1554961 gtaggggcaa actatttttc acccggagaa tgccacacct ttggcagtat tggaaaattt 1555021 gtagatggga gcaataacaa ggccgagttc tttgttaccg attactctgg taaatctaaa 1555081 actgttacgt tttatgattg atggactcaa attgtgaagt ataacccttg gaaaaaaaca 1555141 aaaaagagag atacctctct cttttttatt cttcgacagc cttacgaagc cgttcattta 1555201 caatgccagt ccagccgcca tccatcttac cgcgaacgac ggagcttttc tcgtttgctt 1555261 tgccgatcac ttcattcggc tctttccagc cgctgtgaat aagggtaaac cctgtctttt 1555321 cccccaagtc ttctaattga aaggtaacga cccatccttc tgtatcccat tcaaaagaaa 1555381 gttcagttgg agcttgaaca gccaaaactt tacaagggga cggcccaaac ggcgattgta 1555441 agtgaaattc ttgtccttct ttgagctgaa agtcattggg cataaaccac ttggcaatgc 1555501 cttctgaagt agagactgtc tcccagactt tctgaatggg agcctccaga gtaatgcttt 1555561 ttgtaatatc cggtaatgca ttttcgttgt tttgagccat ttcgtttacc tcttgacata 1555621 tgatgttttt tcaattcaat catataataa ctaataagat catgtccata gcgtgcatta 1555681 tttatgctag agctgctgtt gaacagcgtg tcagtcgcca gtctgatctg tgaatgggag 1555741 aattctgcat gcgcgaaaaa gagagagagg tgtatgttgt catttcgttc attcttgttt 1555801 gcagccgcaa ctgttatgtt tgaactggga ttcctgttca gccaatttat tttgcgattt 1555861 ttgttttaat agtaaatgag ccattttcta aaacaggagg ttttttatgc ttggaaaaat 1555921 caaagcagcc attgataata gtccagggaa gccggccaga attttagtta gtgaaaaagc 1555981 gtttcagcaa ttagaggaag aaatgcgctt tgtttacgtt tccaaaccga aaacgataat 1556041 ggggattcct gtggaagttt cagatcaggc agaaagcttc aagctggaat tttagttttc 1556101 ccagactgct aaaaggctca ttttgtgtta attatgcaaa atggtcaggt tgatttcttt 1556161 aaaagcatga tgaaatgttc atcatgcttt tttattgaga aaaaagacga acataaaaaa 1556221 taggtatacg ggaaaaataa tcctattaga gagaggggaa ctgacagatg gataacatga 1556281 tatcaacact tactgactgg aatgtgtggt ttcaagcgtt agtagtattt ctcgttccat 1556341 atgtaatcta taaagtgttt acttggattc atgtataaga aggtgcaatg atgaggtggc 1556401 ggaacaatca gtacaaaaca cagaagcagc ataaatcaga ttattcgaca gctgaaaagc 1556461 aggatcagga tgtgttaacc ggtaacatcg gatacgactt agaacatgta aaaagaaaaa 1556521 taggacataa cggggacgtt catttccgtg agcttgaaat cactcaatta catgtgaaag 1556581 cggcattgat ctttgttgaa ggactgtctg atcaggactt gattaataaa ggactatcag 1556641 tgttagtcat gaatcaacct aatcaggtaa gcgatgaaat ttctcaatcc ggcaaaggta 1556701 ttttaacttc gaaacagata aaaaatcaaa tcgtatcaat cggtgatgtc atagattcag 1556761 agaaaatcag tgatatcgtg ttgaatgttt tcatgggttc gacagcgctt ctcatcgatg 1556821 gaataccgca ggcctttctt ctgggaactg taaaaaaaca aaatcgaagt atcgaggagc 1556881 cgctttcaga agcgcttgtc agagggccgc gcacaggctt tacagaagag ttgagtacga 1556941 atacagctct tttgagacag caaggaaaaa atgatcaatt aacattgcag agatttgaag 1557001 taggaacacg attaaaaaag gatttaatta tcgcttatat gaatgacatt gcagatccaa 1557061 aagtagtcga ggaagtaaga aaaagagtga gagggattga gatcgatcat ttgccggagt 1557121 caggctacgt tgaacagtta attgaggata attatttgag cccgttcccg caagtacaga 1557181 gtacagaacg tcctgatcgc gtcataagcg gattaatgga aggaagagta gctattctgc 1557241 ttgacggcac tccgtttgct ttgattgttc cagtcacttt cagcatgatg cttcaatcgc 1557301 ctgaagatta ttatgaacgg tggttcccga gctcgctcat cagattgctg aggttcatcg 1557361 cagcaatgat aacgttattc gcacccgctt tatatatatc atttatttct tttcatcctg 1557421 ggttaattcc gaccaagctg gcgatttcaa tttccgggac gcgccaaggt gttccgttcc 1557481 catctctgat tgaagcctta tttatggaag tcgcgattga aattttaaga gaggcggggc 1557541 ttcgtttgcc aaaaccaatt ggacccgcaa taggcatagt tggcggatta atcatcgggg 1557601 aagcagctgt gcaggcgggg attgtcagtc caatcatggt cattgttgtt gcgctcacag 1557661 caatttcttc atttgccatc ccgcattata gcacaggtat agcacttcgg atgcttcggt 1557721 ttggcgcgat gttttgtgcg gcggtgtttg gattgtttgg agtcattatg tattatctgc 1557781 tgctaagcag ccatgtcgta aagctaaaga gctttggtgt gccatacgca agtccggcag 1557841 tgccctatca cttaaaagat tggaaagact ttgttatcag aatgcctctt ttagtcatga 1557901 agcgccggcc taaaatgatg aatacagata atacaaaacg ggtgaagtga tgaactcgac 1557961 aggatggtga taaagtctca tgttcagccc aaccagtaaa atcacaaccg ctcaggcaac 1558021 gattatcatc attaattata tgcttgctgc cggagttctt acgctccctc ggacagtaac 1558081 agaacaaaca caatctcctg atggatggat ttcagtttta ttaggcgggg tcctagcggt 1558141 aatagccggg atgattatag ctaaattaag ccagcagtat cctaaggaga ccttttatga 1558201 atactcccga catattgtag gaaaatggct cgggcatctg atcagtattg tttttattac 1558261 ttattttctg gcactcggtg catttgaagt cagagtcatg tccgaaatcg tggatttttt 1558321 tctcctcgaa gggacacctt cttgggccat cattatgaca gttctttgga ttgggcttta 1558381 ttcaattaca caaggcctag atccgattgc acggcttttt gaaatgattt ttccgattac 1558441 ggtcatcatc tttttaacga tagccctcat gagtttaggc atatttgaga tcaacaattt 1558501 gcgccctgta ttaggtgatg gaatcatgcc ggttcttaga ggtgtaaaga caacgaacct 1558561 ttcatttaca tgttcagaaa ttatgttcat tttagtagca tttatgaaaa agccgaaaaa 1558621 tgcggtgaaa gcagttgtga tcgggacagg cgttgtgacc agtttttata tgattacgat 1558681 gattatggtc atcggtgcac tatcagttga gggagttgtg acgagaacat ggccggggct 1558741 tgacctgatg agaagttttg aaatacctgg tttaatattt gaacggtttg aatcatttct 1558801 gcttgtgatt tggattatgc agctttttgc cacgtttatt atcacttttt atgcagcttc 1558861 cctgggagtc tcacaagttt ttaaaaagaa acccctttca tgtatgtttg ggctgcttcc 1558921 tgttatatat atcctctctt gcatgccgaa aaatgaaaat gacgtcttta tattgggcga 1558981 tacggtcagt catatcgctt tgtatatatt tggcgctttg ccgattttgc tgttagtcat 1559041 ttcgaaatgg aggaaaagag gtgaaaagta aactaaaacg tcaattgcct gctatggtca 1559101 tagtatgtct gctgatgatt tgcgtaacag gatgctggag cagtcgggaa atagaagatc 1559161 tgggtctcac attcgctatc gcaattgata aaggaaaaga aacgaacact gaaaaagagt 1559221 taaaagaaga gggcgggagc tatccgaaaa aagacaacat tacgctgacc tatcaatttg 1559281 ttaatgaaaa agcggcaggc gcgggcacaa gcgggggagg cggtagcgga caaggagcgc 1559341 aaaaagcgta cattaatata agtgaaacag gggattcatt acagcagatc ggaagtgagg 1559401 ttgcattaag acgggaccga gaagtgttta gcccgcattt aaaagttgtt gtcatgagtg 1559461 aagatgtgct gcacacattt cctatcgacg aaatgctgga tcaatttttt cgtgataatg 1559521 aaatcaggct gagctgtctt gttttatctg ctaaagggga agcaagagac gctctccagc 1559581 tgaaagagaa cggagaaatt ccggcatttc ggctgattgg attaggtgaa aatgaacata 1559641 aagtttccag aattcttccc cctatgacac tcgcgaaact aattggaaaa ctgcattctg 1559701 gcagcagctt tttactgcaa aatgtggttg cggcgaatgg agcggtcaag tattccggag 1559761 cagctgtaat caacggaaaa tcgaaaaaaa tgataggcac cttaaatgaa tatgaaactg 1559821 aggggattac atggattaga ggagaaggga aaggcggagt tgtcaaaagt catgataaaa 1559881 agagccaaca gacgttagcg tacgatatca ataaaatcaa aagcagaatt cagccaatcg 1559941 taaaagggaa agatatttca ttccatgtcg atattgaatc agaaggcgat ttggttgaaa 1560001 actggaacac aaaagaggcg ttggacaccc agtttataga tcgtctcgaa acgactattg 1560061 aaaacgaggt aaagaaaata gttggtcagg tattaaaaaa aattcagcat gattataaag 1560121 cagatgttgc gggttttgat gaatctttta gacttacata tcctcactta tggaaaaggg 1560181 tgaaaaataa ctgggatgac accttcagta aagccgacat cacatacagt gtgaacgtca 1560241 caattactca tttcggcacg gttaaaactc agtaatgaat cccaaggaag agaaggaaac 1560301 ctctcttctc ttttttatgc atttattagg ataaagatac tttttttgga gagatataca 1560361 cttttcaaat cgaccaatat gctaatatag gaattgcttg aaatagaagg gagaaggggc 1560421 tgtgaggcag aaaccgattt atgtagaaat cgaaatgaaa tctgatctgg atacactctg 1560481 ggaatataca caaaacccat cactgcataa ggaatgggat ctccggtttt caaatattac 1560541 gtatttgaat agtcagccat gcgaaaaaca gaagtttctt tacgaaacaa gggtaggctt 1560601 tggattaaag gtgtcaggta caggagaaac cgtcggtgtt ttcaacaaat gttcatctga 1560661 aaggtcttct tcactggctt ttggctctga tcatccatta tctctgattc ggcatggaag 1560721 cggctactgg aagtatatac agagagaaaa tgggaaaatg acgtttttaa cacagtacca 1560781 atacaaaaca gcctacggac tgctgggaag atggattgat cgtttattat ttcggccgct 1560841 gcttggctgg gcgactgcct ggagctttga tgcattaagg ctttgggtag agcaaaataa 1560901 acatccgaag cgcttcattc gatctgctat catctatgtg ttcatgtgtc tgtttttcag 1560961 cctgttttgg ttctatcaag gctttgcagg tgttaagaca agcatattga caggaacagc 1561021 ggagataggc ttagctattt tgtggctgct tcctttaaaa agaaaatgga tcattcatgg 1561081 tgtccaggct tgtatttttg ctgggtttgc ttgtctaggt tccgaaatat tcatgtgggt 1561141 tctattgagt gtgttttccg ctgcaagcgg cgctcttagc ctgcagctcc ccagtgccag 1561201 gcgcacaaaa cgaaagagaa agaagtgaca ttgtgagttc gatttatgaa aaatcaatta 1561261 ttaactatca tttgctgcat cccaagctgc agaaacggta ccaattagac gggtctcata 1561321 cattcagcgg gacgggaacg atgtcagaaa taagcggagg ctcttttctg gttagaatgc 1561381 tgttaaagct gggtgttttt ttcagatgct tcttttcaga aagaggcaaa gacattccat 1561441 ttacaataca aaatagaact tgtcttttga aatcgcaaca tacaggaata gaatggaatc 1561501 gtacattttt ctttaaaggc aaaaaacgtt tctttgatgc gttaatgata tatgacgaga 1561561 aagaaaatag aatacttgat ttcttcggca aacctcatct gctgctgtct gttttgacgt 1561621 tcgaggcatc tcttgacggc tctcttacga tcacatcggg aaagcaatgg ctattgatat 1561681 gcggaaaaag aatcccgctg ccgaaatggc tgaccggtac atccgaagtt tgcgaaacgt 1561741 ttgatgaaaa aaagaattgt ttcaccattg aagtgcatgt gcaaaataca attcttggca 1561801 ctcttttctt ttataaggga acgtttcagg aggaagagag agaatcatga aacgaaatgg 1561861 catagtcagt gcgctttgtt ttattggatt tcttgcagca gaagcaccgg atatttcagt 1561921 ggcagaggca ctcgttttgt tatccattct atttttcgtg ccgggaattt ttccttttgt 1561981 ttttcgtcaa tctccggttc gtgctgctca gtttatggaa aacgggctaa tccagtgcta 1562041 tcctgtagcc gcattctttg cggtgctggc tctagtgacg gaggttgggg gtttcgcact 1562101 tatctggtgg atgtacacag tttttaatgc attgtatgcg atcctccgcc tttgggaaac 1562161 aaagatacat agaatcgaag agacatcagt tttgttcggt cttatttatt tggcgggagg 1562221 aggattttgg ttttttgctt atgctgccca tttgcagatc atgcaatttg gccctctcat 1562281 cattttgctg actgctgtcc actttcacta ttctgctttt ctgatcccga tcttcaacgg 1562341 tttactcggc agaaccatta gaaaacatcg gatgttgtac agttggataa catgggtgat 1562401 tttgctttcg ccccttctta tcgcactggg catcacatat tcaaaaacac ttgatgtcat 1562461 tgcggttagc atttatatgg cggcgattta tcttcatgca tttttggtgt tcacggcagc 1562521 ttttcgcacc aagacgggga catttcttat tcggctttct tccgctgttt taatgataac 1562581 gattgctttc tcgatgattt attcatttgg tgtctttcgg caagaagtta cattgaccat 1562641 caatcagatg atttggattc acggttttgt caacgcgttt ggtgttatct tgcccgctct 1562701 catagggtgg agaatagagg atgcgaaacc ttttgatgca gacagtgtaa agacattcag 1562761 ccgtatctac ggaaaaagaa agattggaga agaattttta gctaacattc aagctgaaaa 1562821 taacgctcgg tacagcggac ttgtggatga tatgggcagc ctgcgttcaa aagatttttc 1562881 accagaaaaa ctggcgccgc tcattctttc gttttatgaa caaaccatcg aatacaatat 1562941 taaagcaaaa gtaacatgga gcacgtggtt tcggccgctt gcaattattt acgaatggtt 1563001 cagcagaaga atcggccaaa tacatctttc gacgaaccct gactggtata ggatgtacag 1563061 caagataaaa ggtgttcatt cgaaaaaaga cggaagggaa agagtacgtg cctggattag 1563121 aacaaatgaa aaaaacgaaa ccatttttac cgctctttat tcagtgtatc gttcaaatgg 1563181 agaggggtat atgaatattt ctttaccgct tccattcagc agcatgacag gtattttaaa 1563241 accatatcat catcaggaga agctggtttt aacaagcagg cggagaaaaa gcagagcggg 1563301 ggatgagggg atttatctgc aaacaagagc gggaacttgt ccgcttcctt tatctgaaac 1563361 ctttctgata gaagctgtac atgacaacaa attaaccgct gttcatcata tgtggctgtt 1563421 tggaataaaa tttctaactg ttcattacag cattacacat attaaccagc ctattgaaag 1563481 aacctaacac aaagaagaag cttcgtctgc cagttgtaat gagatgaact gttttaaaat 1563541 tctgcaccgc atcaagacag gaaaggaagg gtttatggtg ttttatatca gtttatttct 1563601 gattctttgg ctggctgctg ggtttgcagt gggaatgaaa caagtgtatg tcgatcagct 1563661 gtttgataaa gctgtgatcg aaagactgga aaaagaagcg aatgatcatg gacatgctga 1563721 ccggatgatc aaacagcgcg tcctttatat tgcagcagtg acagtaagcg ggtttatttc 1563781 tgtttattat gaaatgaaaa caatcccgca aaggcgaaac ataagaaaaa ttgaaaaaaa 1563841 catcatgaaa ttaaatcaag caaaaaaacg aagaatgaag agaaaataaa aagtgcacag 1563901 gccaaagggc aggtgcattt ttgttttgta tggaaaatgg gggaggtggt gccagcttac 1563961 ttttcataaa ttcaaaaatg agaagaacag cgcccgggct aatggtatat aatattgtga 1564021 atttaacaaa aatttaacaa ggaggacgag agaattcgtg ctaaagcctc aaagagacct 1564081 acattctgtt gatttggact tagaggcgga gtagatgaaa ccggccaaag tatccctgct 1564141 ccgccgtttg ctccattcct tgaagcatgt tgattgtaac atagccaaac gttttccatc 1564201 aactattaaa attgtaaaat tattgatgat ttttatggtg tttactccga tttcttcaat 1564261 ttatgctgaa gatgtatatc agaattttga ggaattaaaa aacaatgaag atccttctga 1564321 ttatggcgtt gttacgaaag aaaccggaag ccctgttctt gttttagcta ttcacggagg 1564381 aggtattgaa ggcgggacaa gtgaagtagc gagagagctc agcaaagagt actcgatgta 1564441 tttatttgaa ggcttaaaat cggcaggaaa ctcagtcctg cacattacga gcacacactt 1564501 tgatgaacct cgggccctta aaatgacggg aaatcatgaa tatgtcattt cattacacgg 1564561 gtacgcagaa gaagatcagc agatcgaagt cggcggtaca gatcgcgtaa gagcggcaga 1564621 tttagttgag aaattgcagc atgccggttt tcctgctgta ttgctcaata tggaccatcc 1564681 gcatgcgggc gttagtccga ataacattgc aaataaatca aaaacaggtt taagtattca 1564741 gatagaaatg agcacagggt ttcgaaagtc tttgttcggc atcttttctt taaaaagcag 1564801 agctgttact caaaatgaga ggttttatga gtttacagaa gtgatgttcc gttttctcaa 1564861 aaatagctac tgaaaaatag gaggcgataa gacagcctcc tattccttat gcttctcttt 1564921 cgtttcggga aacagctcgt ccgcggcttc cgtttgatac tgcaacgtgt tatctctcgc 1564981 tgacagttca tttcggaaat tttcatcaag cacatttttc agtaaatacc gatgaaaaaa 1565041 gtattcaaaa acagtaagac aggcagcgga aaggagagcc gctccaaatg gtgagaaatc 1565101 gtttcttgtt tgggttaaaa caaataccca aagaataacg aatgaaaggc caaagtcagc 1565161 caatgaagct gtaatattgt ttgttctggg taagacgagc atgtcaccag aaagatagga 1565221 aacaaaacct aagaaaagtg caataaacat cacacttaaa aaggatgcgt gatagactct 1565281 gtccaaaatc acatataaaa gggcgagagt gaaagcaatc tttgaagcaa gcgcaatgat 1565341 atgtttcatt tgaccaccta aattgttatt ttttgaagaa aattcttggg cgtaaacaaa 1565401 tgataaataa tgcaattcaa aaccattcat aatggtcatg ttactatttt aaacagtccg 1565461 tttttgttta cactggtatt tttttcagct gtatgaaact ttcttatgaa aaaagtcgta 1565521 tatgtggatg atcagctttc aaggggggaa tgatttgtgg agataaaagg aatcaatcac 1565581 ttgctatttt cagtttcgca tttggataca tcgattgatt tttatcaaaa agtgtttggt 1565641 gcaaagcttt tggtaaaggg aagaacaact gcatattttg atatgaacgg catctggcta 1565701 gcgcttaatg aagaaccaga catcccgaga aatgacatta agctttctta tacccatatt 1565761 gcttttacaa ttgaagatca tgaatttgag gagatgtcag ctaaattaaa aagacttcat 1565821 gtcaatattc tgcctggcag agaacgagat gaacgcgatc gaaaatcaat ttattttacc 1565881 gaccctgacg gccacaaatt tgaatttcat accggaaccc ttcaagacag gcttcgatat 1565941 tacaaacaag aaaaaacgca tatgcacttt tatgatgaaa cggccttttg atagcacaac 1566001 catatttcat ataaggttaa atttaaagaa gggtgttggt ggagacttta tgtttgggga 1566061 aggtttctac ccgacttgtt caacgatgcc atatcttttg aactgcacaa gtgattgggt 1566121 gaaggtgaaa ttgaaataca cattacatta cattttatat gaagaaagcg agctgtttta 1566181 tcaaatgttg aactaattaa actatgtact aaattttcag tatatttcaa ttgctttgcc 1566241 ccttaataaa tataaaaccg catccttcca cgacctaaaa aatgaaacgt ttttaagaag 1566301 atggcgtcta atattctaaa tgttcatatt ttgataaaag tttcctaaag gaaagaaaat 1566361 ttcttgactt caacaatctt ttggtggata attatggtgt aaacatgatg ttctttttcc 1566421 tcctattcgg gctcgcaccc aaaagtcagg gcgagcctgc tttttttgaa caacaaaccc 1566481 cctctccgta aaggaagagg gggttatttt atgcatctga tagatcaata gattaatgga 1566541 cggttctgaa cacgccaatc actttcccta gaatgctgac attctgcaaa atgataggtt 1566601 ccatcgttgg gttctcaggc tgcaagcgaa tgtgggtatc ctctttatag aatcgtttta 1566661 cagttgcttc atcatcttct gtcatcgcaa ctacaatttc cccattgttc gctgtgtttt 1566721 gctgtttaac gatgacatag tccttatcga gaataccagc atctatcata ctgtctccca 1566781 taatctccag cataaataca tgctcgtctg gaggaaccat gcggtcaggg agcggaaaat 1566841 attcttcaat attttctact gctgtaatag gagatcccgc cgtgactttc ccgatgaccg 1566901 gtacattaac gacctggctt tgcggaatgt ctacttcttc atcaagaatt tctattgctc 1566961 ttggttttgt cggatctcgt ctgatcagcc cttttgtttc caaacgggcc aaatggccgt 1567021 ggacagtaga actggacgca agcccgacag cctctccgat ctctctcacg gaaggcggat 1567081 atccttttga tttaacctct gctttaataa aacggaggat atcaagttgc ctttttgata 1567141 gcttcgtcat ttttcgcacc tcaaaacgtc gattttaaga agattatagc atgattttcc 1567201 ttacagtaca aacataggtt cgaaaaaaca attgacagaa acgtttgttc gtatatactg 1567261 aaattataaa aatgcgaaca aacattcctg ttggaggtta tgatcatgag taaagaatct 1567321 attatttttg tcggtctgtt tacagtgatt ttgagcgcgg ttatccttat gctgtcatat 1567381 acaagcagcg gccaagagct taatcagtat gttaaaatag aagtccagca aggcgacaca 1567441 ctctggtcaa ttgctgatca ggtagccgat acaaaaaaga taaacaaaaa tgattttatt 1567501 gaatgggtag ctgataaaaa tcaacttcaa acctctgata tccagccggg tgatgagtta 1567561 gtgatcccat tgaaaaagaa gcatcaggat gcatatgaat tagcaactgt aagatagaga 1567621 ggaaagagag ataaaatgaa agcactcatt tatgcccgtg taagcacaaa taaagaacag 1567681 caggaaacgt cattaaagcg gcaggaggag gagcttacgg ccattgcagc ggagaacggc 1567741 atggaagtgg tcaaagtgat ttcagaaaaa gccagcggat atgaaatgga tcgggatggt 1567801 gtatttgagc tgctcgatga gattaagaac gctgatattg atgtcatttt ggttcaggat 1567861 gagacaaggc tcggacgggg aaacgcaaaa atcgcactgc ttcattgtat ttatagagaa 1567921 ggtgtgaaag tctatacaac ggctcataga ggtgaactgg agttatcgga ggctgactca 1567981 atggtcttgg aaatcgtcag cattgtggaa gagtatcagc gaaagattca caacatgaaa 1568041 atcagacggg gaatgaaacg tgcagtaaaa aacggtttta aaccgcaaaa aaacttaaaa 1568101 aaccaacatg ggaacagtgg aaaagaaaaa atagaggtgc caatctcaga gatcgtccgc 1568161 ctgagagcga ataaactgac gtttgctgaa atcgcggcta ccctaagagg gtttggctat 1568221 gatgtctcta aagcaaccgt tcaccggcgt tttcaggaat acatagagaa tgaagagact 1568281 gcagagtgaa tcagttgtaa aacttttttt gatctagtac tatatagaca aaatgcaata 1568341 aaggagttta acatgatttc aaacgcgaaa attgccagaa ttaatgaact tgctgccaaa 1568401 gctaaagctg gcgttattac agaagaagaa aaagccgaac agcaaaagct ccgtcaagag 1568461 tacttgaaag gttttcgttc ttctatgaag aacacgttaa aaagtgtgaa aatcattgac 1568521 ccagaaggca atgatgttac accagaaaag ctaaaaagag aacaaagaaa taacaaactt 1568581 cactaatata agaggaatac ggcaatatcg tattcctctt ttgcatatac tataatcaaa 1568641 actcttatgt gacaaaattc aacaagtttc tctcaaattt aagctgaaac agttgagaaa 1568701 aagtcgtcag acatttatga tgtaagggta caacacataa ggaaggggat ttttatggat 1568761 acaattgaaa agaaatcagt tgctaccatt cgcacactgt caatagacgc tattgaaaaa 1568821 gcaaattctg gtcacccagg gatgccgatg ggagccgctc caatggcata cacgctgtgg 1568881 acaaaattta tgaacgtaag tccggcaaac cctggctggt ttaaccgtga ccgttttgtt 1568941 ttatctgctg gacacgggtc agcactatta tacagcatgc ttcatttaag cgggtttgat 1569001 cttagtattg aagatcttaa gggattccgc cagtggggca gcaaaacacc aggacatccg 1569061 gaattcggac atactgccgg tgttgatgct acaacaggtc cgcttggcca aggaattgcc 1569121 atggcagtcg gtatggcaat tgctgaacgc catttagcgg aaacatacaa ccgcgattca 1569181 tttaacgtag tcgatcatta tacatacagt atttgcggtg atggtgattt aatggaaggt 1569241 atttcttctg aagccgcttc actcgcaggc catcttcagc ttggccgtct gatcgtacta 1569301 tacgattcta atgacatctc tcttgatgga gacctcgacc gttcattctc tgaaaacgtg 1569361 aaacagcgtt ttgaagcaat gaattgggaa gttctttatg ttgaggatgg aaacaatatt 1569421 gaagaattaa cagcggctat cgaaaaagca cgccaaaatg aaaagaaacc tacattaatt 1569481 gaagtgaaaa cgacaatcgg attcggttca cctaaccgtg ccggtacatc cggtgttcac 1569541 ggtgcgccgc ttggtaaaga agaaagcaaa ttaacaaaag aagcttacgc gtggacatat 1569601 gaagaagact tctacgttcc gtcagaagtt tatgagcatt tcgctgtagc tgttaaagaa 1569661 tcaggtgaga aaaaagaaca agaatggaat gctcaattcg ctaaatataa agaagtttat 1569721 cctgaacttg ctgaacagct tgaactggca atcaaaggag agcttccgaa ggactgggat 1569781 caagaggttc ctgtgtatga aaaaggaagc agtttggcat cccgtgcatc ttccggtgaa 1569841 gttctcaacg gacttgcgaa aaaaattcct ttctttgtcg gaggttctgc tgacctagcg 1569901 ggatcgaaca aaacgactat taaaaatgcc ggtgatttta cagcggttga ttactcaggc 1569961 aaaaacttct ggtttggtgt acgtgaattt gcgatgggtg cggccttaaa cggtatggcg 1570021 cttcatggcg gtcttcgtgt attcggcgga actttctttg tcttctctga ttacctgcgt 1570081 cctgcgattc gccttgcagc gttaatgggc cttcctgtga catatgtctt cacacatgac 1570141 agtattgcgg ttggtgaaga cggtccgacg cacgagcctg ttgaacagct tgcttcactc 1570201 cgtgcgatgc ctaacctttc tttgatccgt ccagcagacg gcaatgagac agcagcagca 1570261 tggaagcttg cagtgcaaag cactgaccac ccaacagcgc tagtgcttac acgtcaaaac 1570321 cttcctacca tcgatcaaac atctgaagaa gcattggcag gagtagaaaa aggtgcatat 1570381 gtcgtttcta aatctaaaaa cgaaacacct gacgctcttc tcatcgcttc cggatcagag 1570441 gtaggtcttg caattgaagc gcaggctgaa ttggcaaaag aaaatatcga tgtttctgtt 1570501 gtcagcatgc cttcaatgga ccgttttgag aaacaatctg atgaatacaa aaacgaagtc 1570561 cttcctgcag atgtgaaaaa acgtcttgca attgaaatgg gctcatcatt tggatggggc 1570621 aaatacacgg ggcttgaagg tgacgttctc ggcatagacc gattcggtgc atctgctcct 1570681 ggtgaaacca tcattaacga atacggcttc tcagttccga acgtagtgaa tcgagttaag 1570741 gcattaatca ataagtaagc ttttgaaaga ggatgagtca aatcatcctc tttttcttgt 1570801 ttatccgaca aaaatagtat tggctgttta acagtaatag acaattcttt cttttcttct 1570861 tttgtataat agagagcaaa tgaaatgctg ctggaaaagg ggatgaaaag atggaacgtc 1570921 actactatac gtacctgatc aaagaggaat ttgccaatca ctatttcggc cgggaatcgg 1570981 ttatgtttga gctgtttcaa gactatcatt ggacaagcct tgaaaagcag cagtatgaaa 1571041 tgacagagaa acagattcaa tatattacac aaccaatccc gattttacat atgcatcagc 1571101 ggttaaaaat gaatttaaac aagacggatt acaggcagct ggattatatt tatagaatag 1571161 ctttgccgaa agcaaaaggc cacgcgacgt ttatgatgaa ggagcacatg atagaaattg 1571221 tggcttcggg agattacgag gcagaaacga tattctttga agtgttaaga aaagtaagcc 1571281 cttgcttttt agcaatggat ttcaattcga agcgttacgg atggctaaat ccggtgaaag 1571341 aaagaaattt tgtctaaaac cgaagaaaaa gagatgtaaa tgttgtataa tagcttttgg 1571401 tttagtacac tttaaactag acaacatgaa ggaggaaata aaatgacttt atgggttggc 1571461 atcctagtgg gcgttgttgc attgctcata ggtgttgcac tcgggttttt tattgctcgt 1571521 aaatatatga tgagctacct gaaaaagaat ccgcctatta atgaacaaat gttacgcatg 1571581 atgatgatgc aaatgggaat gaaaccttct caaaagaaaa tcaatcaaat gatgaaagcc 1571641 atgaataatc aaacgaaata atacgtaaag attatgatat agagaaacat ggttataaaa 1571701 taaaaaaccc ttatacgggt tttttatttt gcaatcattc atcacccgct actgctcgaa 1571761 ggcgctgctt ttgatattgt atgagaagat ggtcaagctc ctgactgagc tctatcgtaa 1571821 tatgagatgt cattccgttc gccatgacaa tttgcagcag ctctgctctt tttttttcaa 1571881 tttcttttaa tagatgctct ctaatcacag ggatgtatcc tttcatacat tagatcttca 1571941 aagtgaatgt ttatattata tccatattta tactaatttt caaatgagaa ggagtataat 1572001 gtctcaatgt caaattaaat tatataagtt ttttctgaaa atagaaatcc ttcaagtgaa 1572061 agtgttaaaa aaatgaaatg attttgtcat aacttgaagg aatgtcaaat catgaaggga 1572121 tgatgacatg ggagacgtga attatttttt gacattcgga gcggggtttt tatcctttat 1572181 ttcgccttgc tgcctgccgc tttacccagc ttttttgtca tatattacag gggtcagcat 1572241 ggacgatgta aaaactgaaa agctgctgct gcagaaaaga agcttgtttc atactttgtg 1572301 ttttttgctt ggcttttcag tcatttttat tgctttaggc tatggaacat cttttattgg 1572361 cagcctgttt agggattatc acgatgcgat tcggcaaatt ggcgcgttgc ttattatttt 1572421 gttcggtttc attacactcg gtgtgttccg gcctgaggct atgatgaaag agcggagaat 1572481 ccattttaag cataaaccaa gcgggttttt agggtcggtc ttaatcggaa tggcatttgc 1572541 agctggatgg acaccatgta ccggtccgat attagctgct gttatcacac ttgcaggcac 1572601 caatccgggc tcagcggtgc catacatgat gttatatgta ctcggttttg cggtaccgtt 1572661 tcttttattg tcttttttta tcacaaagct gaagtggata aggaagaacc agcttttcat 1572721 tatgaaagct ggtggcgttt tgatgattgt gattggtgtg ctgttattct ttaattggat 1572781 gagcctgatc attattttgc tgtcagatct ttttggaggc tttactggtt tttgacggta 1572841 aattactttc gtactactac taatcctttt gtttttggta caataagact attatctgtg 1572901 gaaatcgatt gttggagggg aatatgacaa gagttttagt tgtagacgac gccaagttca 1572961 tgagagtgaa aatcagagag atcttggaag aggcaaatta cataatcgca ggcgaagcgg 1573021 cggacggtga acaagcagct gacctgtata aaaaactgcg cccggacctt gtgacaatgg 1573081 atattacaat gccggtgaaa aacggcataa aagcgcttcg tgatatctta acctttgatc 1573141 ctaaagcgaa ggtcatcatg tgcaccgcca tgcgccagca aagaattgta acggaagcaa 1573201 ttgagctggg ggcaaaggat tttattgtta agccgtttga ggaaacaaaa gtgctggaag 1573261 ctgtaagccg cgttatggga cattaaagtc atttcttttc aaaatggttt tttttattgt 1573321 tttggagtat agtatatagt atcaacactc cgagaaacaa aggaatgata agtatgatga 1573381 ttatagtttc atcaattatt gctgtgttaa tggctgtagc tgtgatggtg gtcagaataa 1573441 agtcctctga caagcctgtt tcaccaaaaa aaatcattct tccgccgatt tttatgagta 1573501 cgggagcgtt aatgttttta tttccggtat tttgggtaac tggagcagag tttttggaag 1573561 cattcacttt aggtgtgatt ttctctattt ttctaatcaa aacttctaag ttcgaaatta 1573621 aaaataatga aatttacatg aaacgctcta aagcatttgt ttttatatta gtcggtcttt 1573681 tggtgatcag aatcgtgatg aaatcgatct tgagcacatc aattgattat ggtgcactga 1573741 gcggaatgtt ttggattctg gctttcggta tgattgtgcc ttggagaatc gccatgtatt 1573801 tatcatatcg aaaacttcat aacgagctgc agtcatctaa tattcaaatg aattaaaaaa 1573861 cctttcctct tgtcaggaaa ggttttttat ttgagaaggg tctgataagg ttccaaatcg 1573921 atttttttgt cccgcagatg cctttttaag aaggtatggt ctcttttagg agttgcgaga 1573981 atatagcctt tgatcataag ttgctgatca atctttgcta ccttttcttt taatgcaagc 1574041 tcaccgattt tgcctgcgat tttagctttt gctgcatctc tgaacagctc tggcacgggc 1574101 gcagtcaatt catctagaaa ctgtttgttt tcatcgttcc ataaatgtct gctgttttca 1574161 atatagtaat cctgccaatc aagctctgat ctgccgtcct cttttggtaa acgctttaaa 1574221 aactttcgaa acatgaaaaa accgccgatt gataataaga ctaccatcat gattacccaa 1574281 aacagaataa accataaaaa ccatccttcc agcatcaatc attccccctt attctaacca 1574341 tattgtatac gaagagagat tagaagaaca cagtaaaaaa agaatagaaa aaagtgatag 1574401 acgtctagtc aaaagagata gtagatcata ttctattgta tagtgaatct gctatttggc 1574461 catgggagag tcactagagg gtatttgacg ataaatggac ggaaaaaaag tcactttcat 1574521 aataggggat gaaagtgact ttttatgttt agctgagagg aaattgaaga gaaaaagaag 1574581 agccatcttc tgtttcttta ttgacggcga ctgtgagtat ttgattttcg cattcgactt 1574641 gaatgttttt gtcattaaaa taaaaaggaa gcatcatttg tttttcaaaa gtctgtcctg 1574701 acgatttgac agttaagatg aactcgcatc cagaaagggt aactgttact tgtgtaggct 1574761 gtaaaaaagt cagatccgct tctataatat actgctgact tgtttcatat aaatcaatag 1574821 gcaatgtttc gtcgtaccag gcgaaggggt cttcaaaaaa ttgccgaagc cattcatcca 1574881 tactatcgaa atcattcgca tcgttgcgtt ttgaatggtt catggaagca ttcctccaca 1574941 tatcaacctt gctttacatc atatgcggtg gattataaat gggtgaacgc ataaaaaaac 1575001 agacactaag gtctgctttt cttacatatc atggcttgag ttgtgctttt gtcttgtatg 1575061 gtttcggttt tttacttttt tgcttccgct tagaggctcg ggttggccgg gattgtgtcc 1575121 tttaggggcg tttttatgca tatctttact tgtattctta ttggtcataa aatgagaacc 1575181 tccttaaaag agttcggtgt tattgattgg tttttctttt tttgttattt tggcgttctg 1575241 cttcagtcag tacaagctgg tcgttttcaa tatagccggc gcctttgcct tggctttttg 1575301 cgtcattcat tccgttaatg acgtgattcg cttttctttt gaccatcatt atcacctcaa 1575361 tcataatatg gcttctttta ttgtgttata tgagagagcg taaacagtaa aaattaccgg 1575421 tacatttttc tcataagtcg aacttattgt atttaataaa aacattgata tttacttatg 1575481 tatgattttg ttttaatatg aaattgtgag aaaattgtga tggaatgtaa tgttcatctg 1575541 agaatgatct gatctgaagg gggattttgg agaatggcaa acgagcaaaa aactgcagca 1575601 aaagacgttt tccaagcgag aaaaacgttt actacaaatg ggaaaacata tcattactac 1575661 tctttaaaag cgttagaaga ttcaggtata ggaaaggttt cgaagcttcc ttattccatc 1575721 aaagttcttt tagaatcagt attgcgtcaa gttgacggct tcgttatcaa aaaagaacac 1575781 gtggaaaatt tggcaaaatg gggaactgcc gaattaaagg atatcgacgt tccgttcaaa 1575841 ccgtctcgtg ttattttaca agacttcaca ggggttccgg cagtagtaga tctggcttca 1575901 ctgcgtaaag caatggcagc tgtcggcgga gatcctgata aaatcaaccc tgaaattcct 1575961 gttgatctcg ttatcgatca ctctgtacag gtagataaag cgggtacaga agatgcatta 1576021 gcagtaaata tggacttgga attcgaaaga aatgcagagc gctacaaatt tttaagctgg 1576081 gcaaagaaag cgtttaacaa ttatcaggca gtaccgcctg caacaggtat tgtgcaccag 1576141 gtcaaccttg agttcttggc aagtgttgtc catgccattg aagaagacgg cgagcttgta 1576201 acgtatcctg atacgcttgt cggaacagac tcacacacaa caatgattaa cggtatcggt 1576261 gttctcggct ggggtgtcgg tggaattgaa gctgaagcgg gaatgcttgg acagccttct 1576321 tacttcccag ttccagaggt aatcggcgcg aaacttgtcg gcaagcttcc aaacggaaca 1576381 acagctactg acttggcgtt aaaagtaaca caagtgctgc gtgaaaaagg cgttgtcggt 1576441 aaatttgttg aattcttcgg accgggaatt gctgaactgc cgcttgcaga tcgcgcaaca 1576501 attgcgaata tggctccgga atacggtgct acatgcggat tcttcccagt agatgaagaa 1576561 gcgcttaact acctgcgcct gactggccgt gatcctgaac atattgatgt tgttgaagca 1576621 tactgcagaa gcaatggctt gttctacact ccagatgcgg aagaccctca atttactgat 1576681 gtggttgaaa ttgacctgtc tcaaattgaa gcaaacttat cgggtccaaa gcgtcctcag 1576741 gatttgatcc cgctatctgc tatgcaggaa acgtttaaaa agcaattagt cagccctgca 1576801 ggtaaccaag gattcggttt aaatgctgag gaagaaaata aagaaattaa gtttaaactc 1576861 cttaacggcg aagaaacagt tatgaaaacg ggtgcgatcg ccattgctgc gattacaagc 1576921 tgtacaaata catcaaaccc atacgtgctg atcggcgccg gactggtagc gaaaaaagcg 1576981 gttgagttag ggcttaaggt gcctaattac gtgaaaacgt cacttgcacc gggttctaaa 1577041 gttgttacag gatatcttgt gaattcaggc cttcttccat acatgaaaga gcttggcttt 1577101 aacctcgttg ggtacggctg tacaacatgt atcgggaact caggtccgct ttcaccggaa 1577161 atcgaagaag cggttgcgaa aaatgatctt ctgattacgt ctgtcctttc cggaaaccgt 1577221 aactttgaag gacgtattca cccgcttgtt aaaggcaact atcttgcttc accgccgctt 1577281 gttgtggcat atgcgctggc tggaacggta aacattaact taaaaaccga tccaatcggt 1577341 gtgggcaagg atggtcaaaa cgtatacttt aatgatattt ggccgtcaat ggacgaaatc 1577401 aatgcacttg ttaagcaaac tgttacgcca gagctattcc gcaaagagta tgaaacagta 1577461 tttgatgaca acaagcgctg gaacgaaatt gaaacaacag atgaagcttt atataaatgg 1577521 gataacgatt caacttacat ccaaaaccca ccattctttg aagagatgtc tgttgagcca 1577581 ggcaaggttg agccattaaa aggactgcgt gttgtcggta aattcggcga ttcagtcaca 1577641 actgaccata tttctcctgc gggggcaatc ggaaaagata cgcctgccgg aaagtatttg 1577701 caagaaaaag gtgtttcacc tcgtgacttt aactcctacg gctcccgccg tggaaaccat 1577761 gaagtcatga tgagaggaac atttgccaac attcgcatca aaaaccaaat cgcaccgggt 1577821 acagaaggcg gatttacgac gtactggccg actggtgaag taacatccat ctatgatgca 1577881 tgcatgaaat acaaagaaga taaaaccggt cttgtcgtat tagcaggaaa agactatggt 1577941 atgggatctt cacgtgactg ggctgcaaaa ggaacaaacc ttctcggcat cagaacggtc 1578001 attgcagaga gcttcgaaag aattcacaga agcaatcttg tattcatggg tgtgctgccg 1578061 cttcagttta aacaaggtga aaatgcggat acactcggct taacgggtaa agaagtcatc 1578121 gaggtagatg ttgatgaaac agttcgtcct cgtgaccttg tgactgtaag agcaatcaat 1578181 gaagacggca atgtaacaac ttttgaagca gtcgtccgct ttgatagtga agttgaaatt 1578241 gattactacc gccatggcgg catccttcaa atggtgcttc gtgaaaaaat gaagcagtcc 1578301 tgatgaatca ataggaagag aaggcatttc gctttctctt ctttttatga cacaatgtgc 1578361 tgcggaggtg gcatatgctg aaaaaatggc tcgcagggat cctgcttatc atgctagtcg 1578421 gttatacggg atggaattta tatcaaacat acagcaaaaa agaagtcgga attcaagagg 1578481 ggcaacaagc acctgatttt tctttgaaaa cgctatcagg agagaaaagc tctttacagg 1578541 atgcaaaagg caaaaaagtg ctgctcaatt tttgggcaac ttggtgtaag ccgtgccgtc 1578601 aggaaatgcc tgcgatggaa aagctgcaaa aagagtacgc cgacaaactt gcggttgttg 1578661 cggtaaattt cacttcagct gagaaaagtg agaaacaggt ccgagcgttt gctgatactt 1578721 atgacttaac gttccccatt ctgattgata aaaaagggat caatgctgac tataacgtga 1578781 tgtcatatcc aacgacatat atcttagatg aaaaaggtgt tatccaagac atacatgttg 1578841 gcaccatgac aaaaaaagaa atggaacaaa aactggatct tgattagatt cagttttttt 1578901 tatactcaaa tatgcttaca agttttcaga attggaaaaa ataaaagaat atgcggaggt 1578961 gagaagcgtg aagaagatga gaaaacgttc ttttcatgag ctcgtcatgg aaaacaaaaa 1579021 agagctgatg accaatacag agtatttaaa tcagcttgag gaaaagcttg aacagcgatt 1579081 taagcaaaaa taacctttaa tttgtattca tgtttacccc tccttttgag aaacctatct 1579141 gttgaggagg gataaacatg ggaaacaaca agaaaaacgg tcagcctcaa tatgctccaa 1579201 gccacttggg tacaaagcct gtaaaatata aagccaataa aggggaaaaa atgcatgata 1579261 cttcaggaca gcggccgatt atcatgcaga caaaaggcga gtagcgaaaa ttcgagttta 1579321 tttctaggag gtacatccga atgacaaaga accaaaatca atatcagcag cctaatcctg 1579381 atgatcgttc tgacaatgtg gaaaaattgc aggatatggt tcaaaataca attgaaaata 1579441 tagaagaagc agaagcatca atggagtttg cttcaggaga agataaacag cgtatcaaag 1579501 aaaaaaatgc aaggcgcgaa cagagcattg aagcgtttcg taatgaaata caggacgaat 1579561 ctgcagcgag acaaaacgga taccgttctt aaaaaaccag ggaaacctgg tttttttctt 1579621 tctgatttga ttatggtaaa atggggctaa attgacgtta agggagcaga gtaatcttgc 1579681 atgtatcaaa aaaagaaata gaagtgcgtt atgcagaaac agatcaaatg gggattgtct 1579741 atcacgcaaa ttatcttgtg tggatggagg tcggcagaac ggccttgatt aaggacttag 1579801 gctttttata tagtgatatg gaaaaaaaag gcgttctgtc cccagtcgtt gatatcaata 1579861 tttcctataa aaagccgctt cattacggag aaaccgcggt tgtacataca tggatagagg 1579921 actataacgg atttaaaacc gtctatggtt accacattta taatccggcc ggtgagcttt 1579981 ccatcaaagc cacctcatct catatttgtg tggataaaga aagctttaag ccaattcaat 1580041 tccgcaaagc ttttcctgat tggcacacag catatgaaaa ggccaaaaaa tagggaagtg 1580101 aacgggatat ggcgtttggt gtgaaacggg aggaacttaa ccggtggaaa caagcagtga 1580161 aaagaggaga aatcgcattt ttaacacatt actggctgga tgaccgattt ccagaagcaa 1580221 agaccgtgac aaaagccggc tgtgcagaca ttgataagct ggttcagtgg ggagcggcgt 1580281 acgggttaaa aaaagaatgg atccataaga aaagtgaatt tccccacttt gatctgctgg 1580341 gggaaacaca aaaatatatt ttggaacaag aaaacctaac cgatcatctt atacgatttc 1580401 atttgtaaaa aaagaacgca catgaagtgc gttctttttt attggtattc aaaaaccggt 1580461 tcatcagcgt cttctgaata gctgacgaga aggtcgtggt tatcaaagta ccataaatca 1580521 ctttcttcaa taaagaaggt aatgccatca gcttctgcag tgactccagc ctcttgtggg 1580581 gcatctttcg ctacaccgag agaaaaaccc ttttgaacgt tgctgcagcc tccatagcgg 1580641 acgaaaaagc gaacctggtc tccgctttcc aaatcgagtt cttctttata ccagttcaat 1580701 gcgtcttcgt taattgtcat attcataaca gaacacccct ttgttcttca tttgaatttt 1580761 ctctattata aacgtattag gctattctgt gtcaaaagag aagtttttta agcttataac 1580821 cattttactt taggttctgt tttattgata attcgtttaa tgttcgctcg gtgtctgtat 1580881 atcacaaaaa tagtgagcag ggtaacgaca atcaataaat acgtatcatg gacaaagaaa 1580941 ctatatataa cagtatagat ccctgttaac atcgatgaga gagaaacaaa tttagtcaag 1581001 tataaaaaga tgaagaatac cgcaaccatc gtgataaata acaggggtgc gtaaaatagc 1581061 aaaacgcctc ctgatgtcgc cacggcttta ccgcctttaa atttggcgaa gatgggaaac 1581121 acgtggccta aaaccgcaaa gactcctgca agaagcgggt gaatatcaac atgcatgaga 1581181 aaaggcaatg cagttgccag tgtccctttc aaaatatctc cggctatgac gaccgaacca 1581241 gcttttacac ccaatgtacg gaatgcattg gtagcgccta agttgccgct tccgtgctcc 1581301 cgaatatcaa ttcctttggc aagcttgccc acaattaagc cagatggaat gctgcctatc 1581361 aagtaggcca aaataatcaa taaagcaatt aacatctaca tttctccttt ttcaaattcc 1581421 cttcttttta ttttaacatg agatgtcatg atctgatgat aagttttttt gtaaagtttg 1581481 cttacaaatc aaatcaaaca tgcatcatat tttgatttct cctgttttga tcgtgtaaaa 1581541 taagtgaaaa aggagtgaca cacgatgcaa aacccttcta aagcggaaat taaagagatt 1581601 cttcaaagaa gcaaacgtat agcggtagta gggctttcag accgtccgga tagaacgtca 1581661 catatggttt caaaagcaat gcaggacgcg ggttatgaaa ttatccctgt gaaccctaca 1581721 attgatgagg cgctaggtgt caaagccgtt tcatctttaa aagagataga cggtccgatt 1581781 gacatcgtaa atgtattccg gcgctcagaa cagcttcctg gagtggcgga agagttttta 1581841 gagacagatg cgccagtatt ttgggcacag caagggctag ttaatgagga agcataccag 1581901 atgctaaaag aaaaaggcag aacggttatc atggatctgt gcataaaagt ggcacacgct 1581961 gtaacaaaat aggtgcagaa ctgcaaaaat ccttgtaaat tcaaggattt ttgcttttta 1582021 attttaagat attgtttgcg tattacggtg aaacagatac aataaagctt gaacagcttt 1582081 ttttgaatac cttgtccagc tgggtttcgg ccgttcgatt tgcgaaggtc tgctgcttta 1582141 tatataataa acaaacatac gttctcatag tgtaaaaaca gcactagccg atgttttgag 1582201 aagaactgat tcgttagctc tatgttgcga ttgcaaacat attggttata atgaggagtc 1582261 caaggcagta ctggctcgag gcgaggttta taaaaaatat cttatataca aatgatgtgt 1582321 aacactgaaa agagaaagac aatgttagtt tttgaaaggg gtttgtacgt ttggctagaa 1582381 aacagcaatt tgattacaac gaagatgcca tacaggtgct cgaaggcctt gaggctgtca 1582441 ggaaaaggcc gggtatgtat attggctcta ctgacgcgcg gggtttgcac cacttggttt 1582501 atgaaattgt agataactct gtcgacgagg tgcttgccgg ccatggagat cacataatcg 1582561 tcaaaataca taaagacaat agtatttctg tacaggatag aggccgcggc atgccgaccg 1582621 gaatgcataa gctcggcaaa ccaacccctg aagtgatttt aacggtgctt catgccggag 1582681 ggaaattcgg ccaaggcggc tataagacaa gcggcgggct ccacggagtt ggtgcatcag 1582741 tcgtgaatgc tttatctgaa tggctgacgg ttaccattga gcgggacggt tttgtctatc 1582801 agcagcgatt tgaaaatgga ggaaaaccgg ttacatctct cgaaaagatc ggcaaaacaa 1582861 aaaagacggg aactcttaca cactttaagc cagatccaac gatgttcagc acaaccactt 1582921 ataattttga aacgctctct gagcgcttaa gagagtctgc gtttttgtta aaaggactga 1582981 aaattgagct gattgatgaa cgcaatgacc agcgtgaggt cttttattat gaaaacggca 1583041 tagaagcgtt tgttgcttac ttaaatgaag aaaaagacgt cttgtctgaa gtggtctcgt 1583101 ttgagggtga gcatcattct atagaagtgg actttgcgtt ccagtttaac gatggttatt 1583161 ctgaaaatat tttgtcgttt gtcaacaatg tcagaacaaa agacggcggg acgcatgagt 1583221 caggtgcaaa aactgcgatg acgcgtgctt ttaatgaata tgcgcgaaaa gtggctttgc 1583281 tgaaagaaaa ggataagaac cttgaaggca ccgatataag ggaagggctt tcagccatta 1583341 tttctgtccg cattcctgag gagcttcttc aatttgaggg acaaacaaaa ggaaagctcg 1583401 gtaccagtga agcaagatca gcggtggatg cgattgtttc agagcagctt gcttactttt 1583461 tagaggaaaa tcgggacacc gcaacgcttc ttgtcaaaaa agcaatcaag gcgagccagg 1583521 cgcgcgaagc ggcacgcaaa gcccgtgaag aagcaagaag cggcaaaaaa cgaaaaaaat 1583581 cagaagcgac tttaagcgga aagctgacgc ctgcgggttc aagaaacccg gcaaaaaatg 1583641 aattgtatct cgttgaggga gattcagcag gcgggtcagc caagcaggga cgagaccgca 1583701 gattccaggc ggttctgcct ttacgcggta aagtcattaa tacagaaaaa gctaagcttg 1583761 ctgatatctt taaaaatgaa gagatcaata cgatcattca tgcgatcggc gggggagtcg 1583821 gggcagattt ctcaatcgat gacatcaact acgacaaaat catcattatg accgatgccg 1583881 atactgacgg cgcccatatt caagtgctgc ttcttacctt tttctatcgc tatatgaaac 1583941 cgctcattga gcatggcaag gtgttcattg cgctgccacc tttatataag gtcagtaaag 1584001 gaagcgggaa aaaggaaatc attgaatatg catggtctga tgaagagatg ggggatgtcc 1584061 tgaaaaaagt cggcaaaggc tataccattc aacgatataa gggtcttgga gagatgaacg 1584121 cagaccagct gtgggaaacg acgatgaatc cggagtcccg cacacttgtt agggtcaaaa 1584181 ttgacgatgc ggcacgtgta gagagacgtg tgacgacgtt aatgggagac aaagtagagc 1584241 cgcgcagaaa gtggattgag aaaaacgtcg ctttcggctt agatgaagaa agcaatattt 1584301 tagaaaatga aaacttatcg gtcgctgagg aggtttaatg attgtcacag ccagaattat 1584361 ttcatgattt accattagaa gaggtgatcg gcgaccgttt tggacgctac agtaaatata 1584421 ttattcaaga cagggcgctg cccgatgcga gagacggatt aaagccggta cagcgcagaa 1584481 ttctgtatgc aatgcataca gatggaaaca cgtttgataa aaacttcaga aaagcggcca 1584541 aaacggtcgg taacgtcatc ggtaactatc atccgcacgg tgacagctcg gtttatgaag 1584601 caatggtgcg gatgagccag gattggaaag ttcgtaatgt gttaatcgaa atgcatggaa 1584661 acaatggaag catcgacgga gatcccccgg cagccatgcg ttatacagag gcacgattat 1584721 ctccgatagc atctgagctt cttcgggata ttgacaaaaa cacggttgaa tttgtgccga 1584781 acttcgatga tacaagcaag gagcctgtcg tactcccggc gatgtttcct aacctattgg 1584841 tcaacggatc taccgggatt tcagcaggat acgcgaccga cattccccct catcatctgg 1584901 gagaagtcat tgatgctgtc attaagcgta ttcaaatgcc ttcttgctct gttgacgaac 1584961 tcatggaagt tattaaaggg cctgattttc cgacaggcgg tattattcag ggcgttgacg 1585021 ggataagaaa agcttacgaa accggaaaag gaaaaatcat tatccgcgga aaggctgaaa 1585081 ttgaaacaat cagaggcgga cgagaacaaa ttgtcattac tgaaattcca tttgaagtaa 1585141 ataaagcaaa ccttgtaaaa aaaatggacg agttccgtat tgataaaaag gttgaaggca 1585201 tctcagaggt tcgtgatgaa acggatcgaa cagggctgag agtggtcatt gaactgaaaa 1585261 aagaagctga tgccaaaggc attttgaatt tcttatataa aaatactgat ttgcagatca 1585321 catataactt caatatggtg gctatccata accgccgtcc gatgctgatg agcctgccgt 1585381 ctattttgga tgcatatatc ggacaccaaa aggaagttgt cacaaaccgg tccgtttacg 1585441 agcttcaaaa agcaaaagac agacatcata tcgtagaagg gctcatgaaa gctttgtcta 1585501 ttttggatga agtgattgca acaatccgtt cttctagcga taaacgtgac gctaaaaaca 1585561 atttgatcgc gaaatatgaa tttacagagc ctcaggctga agccatcgtg tcattgcagc 1585621 tatatcgttt aaccaatacc gatatcacag cgcttaagga agaggcagaa gagctcggta 1585681 aaaaaattga agagctcgaa tctattctga gcaatgataa aaaactgcta aaagtgatta 1585741 caaacagctt aaaagcactg aaaaagaaat atgcagatac gagacgctcc gtgattgaag 1585801 aaaaaattga agaaattaaa atcaatctcg aagtcatggt tgcatctgag gatgtatatg 1585861 taaccgttac gaaggatggt tacctaaaac ggacgagcca gcgctcattt gccgcttcca 1585921 acggtcagga cttcggaatg aaagatacgg acaggatgct gcatcagttt gaaatgaata 1585981 cgacagacgt gctgctgctc tttacgaaca aaggaagcta catctattgt cctgttcacc 1586041 agctgcctga tatcagatgg aaggacatgg gccagcattt ttcaaatcta atcactattg 1586101 accgtgatga aacgattgta aaggctatac cgataaaaga atttgatccg tcggcatatc 1586161 ttctattctt tacgaaaaac ggtatggtga aaaagacaga gctcactcat tataaagcac 1586221 agcgttattc taaggcactt gtagccttaa atctgaaggg tgaagatgaa ctgattgatg 1586281 tacatgtaac aaatggggaa agccagatct ttatggccac tcacttaggg tatggtctat 1586341 ggtttggaga agacgaagtg aatgtagttg gcgcgcgtgc ggcaggtgtc aaagggatta 1586401 acttaaaaga ggatgacttt gttgtctccg gtgagattct tcagcaatct gattcaattg 1586461 tcttgttcac acagcgggga gcggttaaac gcatgagtct ttctgagttc gagaagacat 1586521 cccgtgcaaa acgcggtgtc gtaatgctaa gggaactgaa aaagaatcct caccgtgttg 1586581 tagcactgtt cgcttgcggt cttgaacagc gactaatggc agaaacagaa aaaggcgaca 1586641 gaaaagaact gcagacaaaa gagttgcgga caaacgacag atacagcaat ggctctttct 1586701 tttttgatga agaggaatca ggcaaggtta cagctgtttg gcgccttcat acagaacaat 1586761 aataaaaaac ccgctcatac tatatgagcg ggtttcgttt gttttttatc agctttcatg 1586821 gttggtgaat agatctgtta cagcatgaat gacttcaatc ccctgccata caaataaatt 1586881 cagcgctgtg aaagaaaata agcctaaaat caccattctt aagataaaca acatgtttaa 1586941 cagcctcctc atattttcgt tacataatcg ggtgatgttg aacatgaagt ttgccgaaat 1587001 aagacgattg ataaaatttg gccagtataa agcttttttt ccgctgacgt ctgcgggagt 1587061 atcccgtact tttgctttca gcggtcagca gcagaacagc cattgcccat aaagcggtca 1587121 gcgtaaatgc ccctgtgatg gatttcttct catcatcagc attttggccg gctttcatct 1587181 catgcatttc ctgctggtcg gctacggctt tataatgatg gccgatatca aaggcgtggg 1587241 gaattgagaa caaatgaaaa ctggcaatcg ccaagaataa gatggatgct ttcaatatcg 1587301 ttactttttt caaatgatct ccccctcctt taatattact gaatattttt ataataatac 1587361 cccaatccat cctaaaagta aacctgattt attaaattta aaaataaatt taactttgtt 1587421 aagtatatat ctttttgctt atttttgaaa gagaaaactt cttttattag cgtatgtata 1587481 cccggtttat ggtgtgaata aaaacatatt ttaaatgata tgttgtttag gatttattac 1587541 tttatttatg tgtaaatcaa agagaaaggc aagagaatgg gaagaaatga ttacattgtt 1587601 aatagggtac tcttttttta aagccagttt gcaaggaatg tttttattcg taggaaaata 1587661 atagagaagg ggtcgacaga gtaacatctg gctatgacaa tattcttctc gaaaaaactt 1587721 cctaattcgt catattgtga tataataaaa ctcgttatgt taaaaaatct aacatcaaaa 1587781 tcgaattcgt attgaattga tgaaaacggg aggtaaatat ggagtctttt ttcaatagtt 1587841 tgattaatat tccaagtgat ttcatctgga aatacctatt ttatatttta atagggcttg 1587901 gattattttt taccatacgt tttggtttta tccaattccg ttattttatt gaaatgttca 1587961 gaatagtagg ggagaagccg gaaggaaata aaggtgtttc atctatgcag gcattcttta 1588021 tttcggccgc atcccgagtc ggcacaggga atttgactgg tgtagcctta gcaattgcga 1588081 caggcggacc aggcgctgta ttttggatgt gggtagtggc tgcagtaggc atggcttcaa 1588141 gctttgtcga aagtacatta gcacagcttt ataaggtaag agacggggag gatttccgcg 1588201 gagggccggc ctactatatt caaaagggtc ttggtgccag atggcttggc atcgtttttg 1588261 caatcttaat taccgtctca ttcggcttga tttttaacgc tgttcaaaca aatacaattg 1588321 ctggagcatt ggatggcgca ttccatgtaa ataaaatagt tgtagccata gttctggcgg 1588381 ttttaactgc gtttatcatt ttcggcggtt taaaacgtgt tgtcgctgtt tcacagctaa 1588441 ttgtgccggt tatggcaggc atttatattc ttatcgcttt atttgttgtc atcacgaata 1588501 ttacggcttt ccctggcgtt atcgctacaa ttgttaaaaa tgctttaggt tttgaacaag 1588561 tcgtcggcgg cggaataggc ggcatcatcg ttatcggtgc gcaacgcgga cttttttcaa 1588621 acgaagcagg aatggggagc gcaccaaacg cggctgcgac ggctcatgta tcccatccgg 1588681 caaagcaagg ctttattcaa acattaggcg tatttttcga tacatttatc atatgtacgt 1588741 ccacagcatt tattattttg ctgtacagtg taacgccaaa aggcgacggc atccaagtca 1588801 cacaggctgc tcttaaccat cacattggag gctgggcgcc gactttcatc gcagtcgcaa 1588861 tgttcttgtt tgcattcagt tcagttgtcg gcaactatta ttatggcgag acaaacattg 1588921 aatttattaa aacaagcaaa acatggctga acatttaccg tatcgctgtt attgctatgg 1588981 ttgtgtatgg atctttatca ggcttccaaa tcgtttggga tatggcggac ctctttatgg 1589041 gtatcatggc gctgatcaac ttaattgtga ttgcgctgct gtcaaacgtt gcttacaaag 1589101 tgtataaaga ttacgcgaaa cagcgtaagc aaggacttga tcctgtgttt aaagcgaaaa 1589161 acatcccagg gctgaaaaac gctgaaacat gggaagatga gaaacaagaa gcataatata 1589221 aatataaaac aaagctgcat tcaatagttg aatgcagctt tttcattatt ggaaataaat 1589281 ttaatttttc gactcgaatg aaaaatgacg tgtaaagtcc caattcagtc cagttttctt 1589341 tgttctatat gtgtcatgtg tgtcttattc attggaggta gagcaaattg acaggctttt 1589401 aaacctcccc aaaacaagaa attaggttga tagacaatca tgagaaagat ttttacaatg 1589461 agttcgtgct cataagaagt gtagagccaa aatgatgcga aggaggaaaa gatcagatat 1589521 gaaacggtca atctctattt ttattacgtg tttattgatt acgttattga caatgggcgg 1589581 catgatagct tcgccggcat cagcagcagg gacaaaaacg ccagtagcca agaatggcca 1589641 gcttagcata aaaggtacac agctcgttaa ccgagacggt aaagcggtac agctgaaggg 1589701 gatcagttca cacggattgc aatggtatgg agaatatgtc aataaagaca gcttaaaatg 1589761 gctgagagat gattggggta tcaccgtttt ccgtgcagcg atgtatacgg cagatggcgg 1589821 ttatattgac aacccgtccg tgaaaaataa agtaaaagaa gcggttgaag cggcaaaaga 1589881 gcttgggata tatgtcatca ttgactggca tatcttaaat gacggtaatc caaaccaaaa 1589941 taaagagaag gcaaaagaat tcttcaagga aatgtcaagc ctttacggaa acacgccaaa 1590001 cgtcatttat gaaattgcaa acgaaccaaa cggtgatgtg aactggaagc gtgatattaa 1590061 accatatgcg gaagaagtga tttcagttat ccgcaaaaat gatccagaca acatcatcat 1590121 tgtcggaacc ggtacatgga gccaggatgt gaatgatgct gccgatgacc agctaaaaga 1590181 tgcaaacgtt atgtacgcac ttcattttta tgccggcaca cacggccaat ttttacggga 1590241 taaagcaaac tatgcactca gcaaaggagc acctattttt gtgacagagt ggggaacaag 1590301 cgacgcgtct ggcaatggcg gtgtattcct tgatcaatcg agggaatggc tgaaatatct 1590361 cgacagcaag accattagct gggtgaactg gaatctttct gataagcagg aatcatcctc 1590421 agctttaaag ccgggggcat ctaaaacagg cggctggcgg ttgtcagatt tatctgcttc 1590481 aggaacattc gttagagaaa acattctcgg caccaaagat tcgacgaagg acattcctga 1590541 aacgccatca aaagataaac ccacacagga aaatggtatt tctgtacagt acagagcagg 1590601 ggatgggagt atgaacagca accaaatccg tccgcagctt caaataaaaa ataacggcaa 1590661 taccacggtt gatttaaaag atgtcactgc ccgttactgg tataaagcga aaaacaaagg 1590721 ccaaaacttt gactgtgact acgcgcagat tggatgcggc aatgtgacac acaagtttgt 1590781 gacgttgcat aaaccaaagc aaggtgcaga tacctatctg gaacttggat ttaaaaacgg 1590841 aacgttggca ccgggagcaa gcacagggaa tattcagctc cgtcttcaca atgatgactg 1590901 gagcaattat gcacaaagcg gcgattattc ctttttcaaa tcaaatacgt ttaaaacaac 1590961 gaaaaaaatc acattatatg atcaaggaaa actgatttgg ggaacagaac caaattagtt 1591021 aagctttttt ttggcggaca tcagtaacga tgtccgtttt tatcatctaa taggaggttt 1591081 gcgttgtgga tgaaatactg aaacagtata tggtgctgta taaaaaaatg agtaatatga 1591141 taaatggtcc cgactatcca ggtaaggaaa aagacatcca gcatcaaaaa gatcagatcg 1591201 aagtttacga aaaacagctg cagcaaggat tttctacaga ttatgactat gatgtgtttg 1591261 ctgattctgt tatcaaatgc gcatatggcg atatgacgct ggaagattta gaagccgttt 1591321 attatggatt gacaacacca tttttttgat ttgtcattca gcagtaaaat ttcaatttct 1591381 gtctcactaa cttaagtata ctttgatatt gagacagaaa tttatttatt ttgtttactt 1591441 cctagaatat atattatgta aactagaaaa gatgaagaat aaagctttgc tgtttttatg 1591501 tacatccttt cttcttcctg taattcagca acaaaataaa aaagcgattt cccaatcgga 1591561 aaatcgccaa ttcagacact ctattattta tgtgtgtctt tgtgctctta acgatttaca 1591621 acaaatgttg tcacgctttg agctggaaga tgagcccaaa aatgattgcc tgatacagtg 1591681 agattcgttc caggttgtag attgctgctg ctgctcgtga tccatctaga tacgtttgaa 1591741 gcagatccat tctgcaaaac aaagttttgg ttgactcctg tgttgctttt attgatggca 1591801 acaataacga ccttgttgtc acctttatag gctgacacgt aaacgttcgc attagggttt 1591861 ttcgttgcat caatccttac atagccggga cgcacaaact ttgagaaatg agccatattg 1591921 tagccgcgtt tgctgatcgt accatcttct ttcataggtc catatgatct tcggatgtac 1591981 caccatacat aagcttgaaa gtccccctct accatcgcat tgtgaatatg ctgtgaaaca 1592041 tccaatgcct caggccatcg atccgccgag ttggtatcac tgtttggata gtatacttcc 1592101 gtcatccaaa ggtccttccc cgctcctttt tgtttgaaaa gaggataagg gaattggctg 1592161 acctgggtgc cgtacaggtg agttccgaga atatccatat tggcaagagc ctgcggatcg 1592221 ttcaagatcg ggtccgacaa attcttcaag tattgaaatg actcaggcgc aatgacgcgg 1592281 gcattgatcg agccggcgtt ttctctcata aagcgaagta tttcttgcgg cgtccaccac 1592341 gtccactcgt gagcgtaatc aggctcgttt tggaccgaaa tcgcgtaaag attcacacca 1592401 ttattcttca tgaaggtaac aaaatcgtta agatgctgcg cgtatgctgc gtacttgttg 1592461 tatttcagcc gtttagccga tgtgtcacca ttccgattaa aggtctcaac catatcactt 1592521 ggaggattcc aaggagaagc aaaaacgatt gctccgtgtt tgaccgcact ctttgcagtc 1592581 tccacctctt tataccaatt atttcgattt tcatctacat gaattcttaa gattgaaaat 1592641 cctaactggt tctgtccatt gccaaaagca gtttctcttt gagctgctgt aagatcccca 1592701 gcccaagccg gatgattcat ccctccaaaa ccgcgaatca cttgtttctc tgcagataca 1592761 ttaactgtta catcacttgc tgccaaaact tcagtagcgc ctggccctaa catgactgac 1592821 agcatagtga aacatactaa tagtacacaa attgtttttt ttatgcgtgg aatcatttat 1592881 tcctctcctt cgtcatgtgt cttttacggt attaaaaaat ctgcatggca tatccataat 1592941 ggcgggctgt tccggtgctg gcccgtactt cacccgcctc gtttttaagc ggtcccatta 1593001 cgagtactat ctttgcgtaa actgccagta atcaaaatta aacaagtttc ctgtacctgt 1593061 tccggtaaat acaaagaata ctttgtgcac accggttgcc ccgcttaccg cagtttctat 1593121 ttccctccac gtttgcgctc cgcctgttga aggcacattc agagttccaa caagcttacc 1593181 gtctgcactg tcgaggcgca cttctatttt cccgcctaaa gtggatgcta catttgcttt 1593241 aaatgacctg gcaccgcccg ctccgaagtc tgcatttcct acagcaatcc agtctccatt 1593301 ttgaatgctt gttacatgct gattatttac tggcccgccg ggtgctgtgg acttctctgt 1593361 caaaatgcgt ccattccaag caaacgtttc agcttctacc cggttatatg ggtttaaatt 1593421 ggaaatttgt gttacacctg cataatttgc cgctacctct tgaatagatc catctgcatt 1593481 atgcaccagc ttattaatat ggggagagcg gtatcctttg ccggccccga acagagcgga 1593541 actgacagtt tgcgcatggt acaccacata ccactcgttt ttaaaattga aaacagcatg 1593601 atggttgttt ccgccacctc cgaaaaatgc acccggattt ttcaggaagt gccctctata 1593661 tgtaaaggga cccatgggac ttgaactggt catgtagccg atctcacccg ggggtttatc 1593721 ggccgggtgc gtgccgccga aattgatgca ataggagtaa taatatgttc cgttatactt 1593781 gtgcaatccc gaatcttcaa acatgaaagg cgcatcaatt gtagatgcac ttccaacaac 1593841 actcgtcata tcaggcccca attttatgac tctagccgtt ttaggattgg cccattgtcc 1593901 ctgcgttgga tttgaaacgc caggaacgcc tccgccggca tacaggtaac cggttccgtc 1593961 gtcatctaca aatactgccg gatcaaaaag ccatacaaca ccagacattc ctggcgtact 1594021 tggcgttacg agcggttttc cgattgggtc ggtccatgga ccaatcgggc tgtctgcggt 1594081 gagaaccccg atacctccgc cgctgtttgc gaaataaagg aagaatttat ccttgccatt 1594141 aattttttta actgcgattg acggtgccca tgacgcacct gcccattttg caattccacg 1594201 gcctccatta gctccattgg cacctgctac cggaatggct ccgtggtctg tccagttcac 1594261 catatccgct gaagatatga cgaatactct attcaaattg gcaaatgaat tatctttaat 1594321 tgttccgttg ctattatatt catagtcatc acttgacata tagatgtaga ctcttccgtt 1594381 ataggtcagc gcaaccggat ccgctcccaa atgatggtcg ataagcggat ttgaattccc 1594441 tatatgtttt gcaattgtag tactagtggc agcatacgca gacttcccag ataagcagct 1594501 caataataaa actagaatcc ataaacatac gctacacttt ttcctcatca cttcacatcc 1594561 tcctttttcc ttaaaatggg ggattttctt ttggaatttg ataacaacag gtcacgaaga 1594621 ttgcacgcat aaagtagccg gaagctgttt agcaatgttc ccagttgttc tgaaagctca 1594681 tcttcatgtg tctccattct ctcttttctt cgaggagatc gcaccactcc ttcaaaattg 1594741 ttcaaaaaaa cttccccatt cctagcgacc attgtccaga aaataaaaag acaggattgt 1594801 tcatggcctc ccactaatca cattgaacgg agattacatc attatccaag atatcccttt 1594861 atctaacatc ctacatcatt aaaaaaattg tgtatagaaa cttttggagg agttagtgtt 1594921 cgattctaca aaggaactgg atacatttat tcattgataa gatggggcta acactccgtt 1594981 tatatttgta tgttttcaga cacaaaaaac agccgttcaa tgcggctgtt tttttcaaga 1595041 gtataagact attgagcggt atacccgctt tttcatgttt tgttcatatt ttattaattg 1595101 tttattcaac actgtccgct atagtaatcc atatcaacaa atatgactgc cactcgcatc 1595161 ttttatgaag ggaggttcgt tacgctgaaa gaaaaaataa agacattagg ccgtttttgc 1595221 accgtaggcg tcggcaatac gctgatagat tttggtgtct tctttcttct taccgcttgt 1595281 catgtctctt atctgccggc gcagatctgc tcctatactg caggtatcgt caacagctat 1595341 gtgtggaacc ggaattggac gttttgtgtg aaacgtaagg ctgacgggaa agagatcgtg 1595401 cgttttctca tgattaatat tgccgcgtca gggatcacct ttttgctgct ttatttgttt 1595461 caaaattgcg gctgctcgct tttggtgagt aagctcgccg ccactatcgg cggaatgatg 1595521 atgaatttta tcggaaaccg aatctgggta tttggagatt cgctgaaaaa catacaggat 1595581 caggagtgaa gatgaatgag aaaaaaagtg agaaaagcgg ttatacccgc agcgggttta 1595641 ggaacgagat ttctgccggc gacaaaggcg cagcctaaag aaatgcttcc aatcgtcgac 1595701 aaaccagcaa tccaatatat tgtagaagag gccgcagagt caggaattga agatatactg 1595761 attattacag ggagaaacaa acgctcgatt gaagatcatt ttgatcggtc ggcggaattg 1595821 gaattcaatc tccgggaaaa aggcaagacg gagacactta aggaaatgca gcagattgcc 1595881 gatttggcca acattcatta catccgccag aaagaaccgc tcggattagg ccatgcggtg 1595941 ctgtgtgcgg agcattttat cggagatgag ccttttgctg ttctcttagg tgatgatatt 1596001 atggtgtctg aaacaccggc tcttcggcaa ttaatggatg tatatgacgt ttatggcaca 1596061 gaggttgtcg gtgtacagtc agttctccct gaggatgtca gcaaatatgg tattataaat 1596121 acatcagggt ctcaagggca tgtatatgaa gtgaacgatt tagtggaaaa gccttctcct 1596181 gaagaagcac cttcggaaat cgcagtaatg ggacgttatg tgctgaattc ttcgatcttc 1596241 tccgttttga agacaattgg cagaggcgcg ggcaacgaaa ttcagctgac agatgcgctt 1596301 cgtgaggttt gccgtaagga gccgatccat gcccggctgc tggaaggaaa tcgatatgac 1596361 attggcgata agctgggctg ttttaaagcg agcaccgaaa tcggcttaat gcgtcccgaa 1596421 atgagatctc agcttttggc ctatttagaa gatgtgatca aacgggaaac gaaagaaatg 1596481 ctgcggtaaa aaaattgtaa ccatcttgct cgtcaatcag tcatataata gtgaaaaaga 1596541 ttaggacagg ttgtgaagaa tgtgggcagt ttgataagcg aaattttaac atggctgacg 1596601 aacatgggat atgcgggtat tgcgattggg ttaatgattg aaatcattcc gagtgagatt 1596661 gtattagctt atggcggcta tatggtatcg gagggcacga ttggatttat tggcgcaatt 1596721 attgcgggtg ttatcggggg caccattgcc cagatcttta tttactggat cggtcgctat 1596781 ggcggcaggc catttctgga caaatacggg aagtatttat tgattaaaaa gcatcatatc 1596841 gatatgtcgg aaaactggtt tcagaaatac ggcgccggag ttgtcttctc ggctcgtttt 1596901 ataccggttg tcagacatgc catatccatt ccggcaggta ttgccagaat gccttttctc 1596961 aaatttgtgg tactgactgt gcttgctatc attccatggt ctatcctgtt tgtttattta 1597021 ggcatacagc taggaagcca gtgggatgat gttgagaata tagcaggcac ttatacaaca 1597081 ccgattatga tattggctgt tgtcgtgata gccctttatt ttgtgattaa gaaacgtaca 1597141 gccatattta aacgatagct agcggatatg cataggggtg actgacgctc ccctatgcat 1597201 atttttttac ttgcgatgtt gatttgccag cttcagattc tccgctaaaa atgcgacaaa 1597261 cacttcatcc cgcacgagcg atgcggcata atttctctta ataaaccatt ctgcctcttc 1597321 aaacgctgcg aatgtttcgt cttgggtttc tccgttaatt tgaatattcc attcgttgtc 1597381 taaagggaaa agaaaaaatc tcatttgtgc gcgattttca tataatgatc cattcgcaga 1597441 tccctttaga ttatagatgt tacggaaggc atccggccgt acaggatcaa tacggaaagc 1597501 ttcagctaca aacaactcgt atacttcatc ggttattgaa cagccggacg cttttgcatg 1597561 ccctccgccg ccatatcggc cggcgatttc tgacacatcg atgtaatcat gaatggtgcg 1597621 gagactgact cgttttgacc ccatgctcaa aatcgcaatg taatcgaggt gcgggttatc 1597681 tttccctagc ctgttcccca gctctgaatg gtacgattca gcgtgaacga tgcctacaca 1597741 gtgttcgtga acaaaggttt gtaccatttc ccttttcttt ctgcggaggt agcgctcgat 1597801 tttttcgtct tctaaatcaa gcagtttttc ttcaaaatca tcgaagaaaa attcgtcatg 1597861 cgtggaaagg cgctggatca tttttgcttc aaattcatcg attgacagca aaaagaaaag 1597921 atcattaagc cgcttcgcct gtttttgatc gtaccgctcc cactcccatg tatcgtattg 1597981 gcggacgagc tctgtgaatt gatctaaggc gtttgtcggt ttcatgaagc cattttcaat 1598041 gagatagcca tataaaagcg atgtcgcgga tgtgagcctt ccatcatcgt attccacctg 1598101 gacaaatccc cattcatgct cattcaaatg aagggctgtt ttatgatggt caatgagctt 1598161 cactttgccc cctgcatgaa catactcatt caatctctct tcgttttctt cattgacggc 1598221 gagatcggtg atgaataacg cgtcctgtct gttgctctcc ttcgcttttt ctaaaaagta 1598281 ctgcacctgt gcgtttaagc cgttgacaga gttataccgg atctctacgt cttttccgaa 1598341 cgccaatttt gctacgattc cgcatcctac tccgtccaag tcgttatgtg aatataaatg 1598401 atacataatg taggcccctt tttatgataa actgacaatt gccgctagag gtgcggcagc 1598461 ctttatttac tattctaaaa aaccaagcgt tttatgcaat ggtaattagt tgacataatg 1598521 ttgttattgt aaatatataa aggagcgctt tttttgcgct cctaagttct tgcttttaca 1598581 ccggataaac cggatgcttt cgattggtaa atgtcatttc ctttgtcatg tatgccttga 1598641 gccgtttggc cagctcatca cgcagcgaat tggctgggat aacagcatca atgatcattt 1598701 ctgaagccag acggtagata ttgatgtcct ctttgtattc ctcccgtttg ctgctgataa 1598761 atgcggctct ctcttcttct ggcagctcgg cgattttttt agcgtagaca gcgtttacag 1598821 cggcctcagg gcccatgacg gcgatttggg cggttgggag cgctagacag caatccggtt 1598881 caaatgccgg ccctgccatt gcatacaacc ccgccccgta agcttttcgg acaatgacag 1598941 agagttttgg aacagttgcc tccgacatcg cagaaatcat tttcgctccg tgtctgataa 1599001 tcccagcctg ttctactttt gtgccaatca taaaaccggg gatatcggct aagaacagca 1599061 atgggatatg aaaagcgtca cataaggtaa taaacttagc cgctttgtct gctgaatcgt 1599121 ggaataagac gcctcctttt accttcggct ggtttgcaac aatgccgaca ggctgtccgt 1599181 ggattcgtgc gaggcccgtc aataattccg gtgcaaataa ggctttgatc tcaaaaaatg 1599241 agtcttcatc tatgacccgc tcaatgagct catgcatatc aaaaggtgcg ttttgatttt 1599301 gcggaatgac gtcggcaagc ggagtttcga agtgttttgg cgggcgtttc tcatgaatgg 1599361 gcgctttttc ttgaaaattt gccggaaagt aagacaaata agcccgcacc agctgtatgg 1599421 cttcttcttc agtttctgca agaatatctc cgcagccgga gattgagcaa tgcatacggg 1599481 cgccacccat ttcttcgaga gacacttttt ctccaataac catttccgcc atccttggcg 1599541 aacctaaata catggaggcg ttaccgtcta ccataacgac gatatcacag aaggccggaa 1599601 tataagcgcc tcctgccgca gatggtccga aaagcagaca gatttgcgga atgcgtcccg 1599661 ataatttgac ttgattgtaa aaaattcttc ctgcaccgcg tctccctgga aagacattga 1599721 tttggtcggt aattcgggcg cctgccgaat cgactaaata aatgagcgga cagtttaatt 1599781 tttcggcgat ttcttgaatt ctgatgattt tttcaactgt ttttgctccc catgaccccg 1599841 ctttcactgt tgaatcattc gccatgacgc aaacggtttg gccgccgatt ttgccgatag 1599901 cggttacaac tccgtcagcg ggaagcccgt ctgacataca ttccgcaaaa aaagcgtctt 1599961 ctagctcaat gtcatcgtca aagagaaggg aaagccgctc tctgacaaag agcttgcctt 1600021 tttcccgatt gctttgatga tacttttccg ctccgccttt tcgaatccgt tcagcccgtt 1600081 ctgttcgttc cttttcataa tccatcagca ttgcctccct tttatattcc cttgtatacg 1600141 gcccgtcttt tttcttgaaa ggcctgaagc ccttctctcc tgtcttttgt cgggatggtt 1600201 tgttcatacg ctttttgttc aatcgcaagg cctgtagcaa gatctgtctc caatccttta 1600261 ttgattgcaa atttagcctg acggacagcg atcggtccgt tggcagaaat ggctgcggcc 1600321 agttcctctg cttttggcat aaggtcacaa ggagccgtga catgctctac aaggccgatt 1600381 tcttttgctt cgtgtgcggt cacgcgtctg cctgtataaa tgaattcttt tgcttttcct 1600441 ctgccaatca gccggggcag cctttgggtc cctccagcgc ccgggataat agctaaccct 1600501 gtttccggaa gtcccagcac agctgcttca gttgcgattc gaaggtcgca tgccaatgcc 1600561 aattctagtc cgccgcctaa tgcgcttcca tttatcgcag ctatgaccgg ctgcggcaag 1600621 gcatcaagta aagccgccgt tctttgaatg agagatacac tttccagaac ctgatcttct 1600681 ttcagtttta tccgttcctt caggtctgcc cctgcacaaa acgctttttc accggtgcct 1600741 gtgaggatga cgcaacggat gtttgagtta aattcaattt cctggataat catttgcagg 1600801 tttctaagca tttccgctga aagagcattt gctgcctgag gcctgtttaa ggtgatcaac 1600861 gccatatgtt catttttaac agtaaaaaga atagaatctc ccattgtatg cgtcctccct 1600921 tttatcaaga tgatttaaac acctgtaaat ttctgctcgg cagcggtttg cccatttttt 1600981 cttcaatcca tttggccgca gatagcagtt tttctagctt tacatttgtt ttgatatcca 1601041 tctgttcaag catgtacacg atatcctcag ttgcggcgtt tcctgatgaa cctggcgcat 1601101 atgggcatcc cccaagcccg cctgccgagc cgtcgaacac cgtgatgccc atttggagtg 1601161 ctgtgaccat gttggccaga gcggttcctc tcgtatcatg aaaatgcagg gcaatttgat 1601221 tagccgggaa tcgtgccaaa agagcttcaa gtacagtttc cacttgggcg ggattagctg 1601281 ctccaatcgt atctccaagc gacagttcag aaatcccaaa ttcaaataga gcttctgaaa 1601341 ggcgaatgac ttgttcaatg gggacatctt tttcgtacgg acagccgaaa acagtcgaga 1601401 ggtaggctct tgttgtgagg tttgcttttt gtgcgtcgtt gtttacttgt ttgagtatat 1601461 ggagggattc agaagtggat ttattgatgt tttttctgtt gtgcgtctcg ctggcggaca 1601521 taaaaacgca agcctcgtta atgcctcctt caagtgcatt ctccagtcct ctttgattcg 1601581 ggacaagtgc cgcgtacgtt accccttttt ctcggtcgat gccttttgct acatcgatag 1601641 catctcgaag cgccggaatc catttcgggt gaacgaagga tgtgatttca atatacgaca 1601701 gccctgtccg ggaaagctgg ttgatccagg ttattttatc ctctgttgcg atccaaacgg 1601761 gctcgttttg taagccatca cgcgggccga cttctttgat tgtcactttt ttaggatatg 1601821 gcatggtctt cctccaaatt attgagtgga attgctcagt tcgagcagta cgtctccttc 1601881 atttacaaag tcgccttcct tttttttgac ttcttttacg attccgcttc tatctgcaac 1601941 gatcgggatt tccattttca tcgattccaa aatggctacc tcctggccct tttcgatttg 1602001 gtcgccggct ttgacgtgga ctttccacag gtttcctgcc atttgtatgc taaccgtcat 1602061 gacaactgcc tcctttatag gtgctgtttc aaaaagtcag tcgtgacatc cccttcttta 1602121 aatgcctttg ttgccgcagc ctgtatgagg agcggaaggt ttgttttgat tccctctaca 1602181 cgatagtcgc gaagcgctgt ctctagtttt tcaattgctt ctgttctggt ttggcctttg 1602241 acaatcatct tagcgatcat cgggtcataa aaaggggtaa cggtgctgtc ttttgctacc 1602301 gcacattcgt gtctgactcc tttttggtca ggaagtgaaa acgcagtgat cgtacctggt 1602361 gacgggaaga aggtcttggg atcttccgcg tatattcgaa cctctatcgc atgcccgttc 1602421 cgttggatgt ctttttggga gaatgtgagt gtatggcccg cagcaatccg cagctgctgc 1602481 tcaactaagt ccaggcctgt tatttcttca gtcacggggt gttcaacttg cagtctcgta 1602541 ttcatttcga ggaaataaaa attttgtttc tggtcaacta taaattcgat ggtgcctgcg 1602601 ttcgtatagc cgattgcctt cgctgctttt accgctgttt gaccgatctt cattcttagt 1602661 tcatcgtcta caaatggaga cggtgcttct tcaatgactt tttggtggcg cctctgaaca 1602721 gagcaatcac gttcaaacag atgtactgta tggccgtgtt gatcggccaa aagctgaacc 1602781 tcgatgtggc gcgcatgttc aataactttt tctatataca tagacccgtc accgaaaaaa 1602841 tctgctgcgc gctttttgtt tccctcgtac gcttttttta atgcttcttc attttcaaca 1602901 cgctgcattc cgatgccgcc tccgcccgct gaagctttca gcatgacagg atagccgatt 1602961 tgacttgcgg tgcggcaggc tgcctctata tctccgaggg attcagaaac gcccggcacc 1603021 acagggacac ctgcagcctc cattgctttt cgcgcttcaa ttttgctgcc catctttgcg 1603081 atgatatcag gggaaggtcc gataaacacg atgttttctt gcttgcagcg ttcagcgaac 1603141 cggctgtttt ctgataacaa tccatatccc gggtggatcg cgtcggcttt tgcttttttc 1603201 gccgtcttta tgattctctc tatatttaaa taactttcac tgactctcga ttccccgatc 1603261 aaatatgcct ctgtagcggc ttttgtatgg ggcgcgtcct tgtctgcttc tgaataaaca 1603321 gcgaccgttt taatgccgag acggctgcat gttcggataa ttctcattgc aatttcaccg 1603381 cggttggcga tcagtacttt tgtaaacatg atttcacctc attgacttga tgataagttg 1603441 aacatttcaa tcgttttttc tcgcagttta tatttttgaa ttttgcctga ggccgtcatc 1603501 ggatagtcat ccgtaaaaat aacataacgc ggaattttgt ggcgggcgat tttccctttg 1603561 caataggctt taagctcatc aggtgaaacg cttttaccgt ctttcagttt aatccaggct 1603621 gcagcttcct ccccgaattt ggcgtcaggc acaccaacca cctgtacatc taaaacagcg 1603681 ggatgctggt ataaaaattc ttcaatttcc cgcggataaa tgttctcgcc gcctctgatg 1603741 agcatatctt ttaatcttcc ggtgatgcgg cagtacccgt cttcatccat gacagcaaga 1603801 tctccggtaa acagccatcc gtcatgattg attgcttttc tggtcgcatc tttgtcttta 1603861 taatagcctt tcatgacgtg atagccacgg gtgcacagtt ctccctgcat gcctctttga 1603921 acttcttgac atgtcccggg ttctacaatt ttcacctcag tatgtggcag ggcacggccg 1603981 gttgtttcga ctcttcttat gaaggaatca tttgctctcg tttgtgtaat gactggcgag 1604041 gcttcggttt gtccataggc gatcgtaatg tctttcatgc ccatcctttc aatcacagct 1604101 ttcatcactt cacttggaca gggagagccg gccatgattc ctgttcggag cgtcgataga 1604161 tcatatgcat caaaatccgg atgatgcagc tcggcgataa acatggtagg cacaccatgg 1604221 agcactgtgc atttctcttt ttctaccgtt ttaaggacgg taacgggatc aaattcttgc 1604281 acgggtatca tggctgcccc gacggataca catgccaaaa ccccaaggac gcatccaaag 1604341 cagtgaaaaa acggaacagg gatgcacatg cggtcttgag aggttaaagc catacattca 1604401 gcgatattag cagcgttatt gatgacattg aaatgggtca gcatcacgcc ttttggaaac 1604461 cctgtcgttc ctgatgtgta ttgcatatta atcacattgt ctttatccag gctgttcatt 1604521 ctctcttcaa gctcagcatc tgtcactgtt ttcgccaata tctctgtatc gtcccaatga 1604581 tacatgccag acaatcgttt attgccaata tagatcagcg tttttaaaaa gggatagcgt 1604641 tcagatttca gttggccggg ctttgcttct tgcagttctg gaattaaact gttcacgatg 1604701 tctggataag aagtgcccct gtatgaatcc atgataataa gcgccgcggc atccgattgc 1604761 tttaacaagt aatcaagctc atgtgcttga taattggtat tgacggtcac gagcacggct 1604821 ccgatcttcg cagttgcgaa ctggacggca agccattcag agatattaga agcccatatg 1604881 gcgacgtggt ctccttttcc aatccccatc cgcatgagac ctttagcggt ttgacggcac 1604941 agactgtcaa attgagcgta cgtatagcgg atatttcggt ctggatacac aacagcatct 1605001 cgatcgggat acgcatcagc tgtttgttcc agcagcctgc cgattgtgga atggatgagt 1605061 tcagccattc attgttcctc ctttcttaat gataggaaag cgtttacatt tttattttaa 1605121 aagctgtctg gcgatcacga gacgctgaat ttcagatgtg ccttcaccga tttccattaa 1605181 ttttgcgtcc cgcagcatcc gttccacccc atactctttc atatagcctg aacctccatg 1605241 gatttgaatg gcttgattgc aagctcttgt cgccatttca gatgcgaata gcttggcgta 1605301 cgccgcttct ttggtgaacg ggcggttatg atctttcagc caggcggctt ttaacaccat 1605361 ttgccgtgcc agatcaattt ccatcgccat gtcagcaagc ttaaattgaa tcgcttgaaa 1605421 ggaagaaatc ggctgtccaa actgctttcg ctctttcgca tatgccaatg atgcgtcaag 1605481 ggccgcttgg gcaatgccga ctgcaagagc agcgatggag attcgaccac catccagcgt 1605541 atatagaaac tgtttaaacc cttttgttgg atcgccaagt aagttggccg caggcactct 1605601 tacatcttca agcaagattt ccgctgtatt cgaaccgcgg acgcccattt tatcgtacgg 1605661 gctcgtaatc gtaagtcctg gtgtgtcagt tggcacgatt aatgcggaga tgatgttttt 1605721 tccgtctttg tttttgcctg ttacggcggt tacaataact gtgcgtgcgt agcttgcatt 1605781 agtgatccag cacttttcgc cgttgattac atactcgtca ccatttgaaa tcgcttttgt 1605841 ttgagtgcct cctgcatctg agccggcatt tggctccgtc aggccgaatg atccgagtgc 1605901 tgtgcctgaa gccagcggcg tcaaatgcgt ctgtttttgc tcttctgttc cgaagtagta 1605961 aagagggctt gcgcctagcg agaccgctgc agcatagctt aatccagtac tgccgcaggc 1606021 tttgccgact tcttcaaccg ctaaggcata tgaaatcgta tcaccgccag atccgccgta 1606081 ttcttctgga aatggaatac ccatcagacc gagttcaccc atttttttaa atgtttgcat 1606141 cgggaactcg cctgtttgat ctacatgttc agcgtgagga gcaatttctt ttttcgcaaa 1606201 atcttttacc atttcacgca ccatttgttg ttcttttgtc agctcaaaat tcacatcgtt 1606261 tcctccttca catctttgta acatcctatt aggcgagttc tataatcatt ccctgacaag 1606321 aaaagtctga aaattaaaac tgaatcattt tttatgtgat aatatcagcg ggatgagcaa 1606381 atacatgcag taggcgcata ccatccatat cgtaaacgca ataacttggc cctttgataa 1606441 agccgggaag atgaggggaa gattccaaag ggaaatcgta tccatcaata aaccgaccgc 1606501 tgatccccat atacctagct tgatcaccgc gaactgtgat tgatcgagtt tttgatagag 1606561 aaagaacaca aggcataaaa caagagcagt gcccgctccc aagagaagaa agttcggcaa 1606621 aaaggcttct tcagccggat cagtcaacac agcatctccg aacagcacaa aaaataatgt 1606681 ggcacctaac cagactagaa atgaaaacgt aaaacacgtc ctgtacgtgt ttctcttcga 1606741 ttttattttt atttagtact agtttctcag attccaataa tggtaaatgt ccaaacaccg 1606801 cctccatatt catgtgaatc tcacctttgt tttttaaaaa attcagcggt ttaccatcgt 1606861 ttcctgtccc aaaatcactt tttaaaaaaa gacgacttag aaagccgtcc ttctcatttc 1606921 ttattttgtt gttcgtttgg aagctttgct ttcgttatga agccggtctg ctgaagtgac 1606981 ataatacgta tatttcttgt tgggatctgc cgtgttatct aagaaggttt gctgctcatg 1607041 tgtttttctt tgcgttgcca gcaatgttct ctgctttttc ccttcggctc tgtatatcgc 1607101 ataataggct gtttctttcg ttttttgatt tgatgggtga tctttaatct gcagaagatt 1607161 gccgtttttg tcttcggtga ctttcgtaag cttcggtttt tttggggcgg tattgtcaag 1607221 ccaaggcatt tgcggaacca gtgccggctt gctgtaaaga tcggtgctga gactgtcttt 1607281 gatgccaagc ggatttttgt tgaggtcctt gaggctgaaa tgcatgcttc ctttcaccag 1607341 ttcaagctgg cggttcaaag tgatttgccg cacatattcc tcaggatcgg accaaggcgg 1607401 atcaaaattg ttattgattt tatatgctgc ctggccaata tataagtgaa caggcctatt 1607461 tttgacttca ttgctccacc aatcagccag cacgtcgtaa gccgctgcgt taaagccgat 1607521 actccaataa atttgcggag caatataatc gatgtcgcct tcttggatcc aatgccttgt 1607581 gtctgcatat agatcgtcat aatttctgac gcctgctttt gtattcgatc cggtcgggtc 1607641 atctgcggcg tttctccata ctccaaaggg actgatgccg aatttgacat acggttttgc 1607701 agctttaatt gtttggttga tttgtttgac aagctggttc acattgtccc gccgccagtc 1607761 atcgatatta gaaaaagcgt cttttccgta ttgttcgtac tgtgcttgat caggaaattc 1607821 ctgtcccgct attttataag ggtaaaaata atcatccata tgaacagcat cgatatcata 1607881 atgttttacg acttcttcaa tgcctttgac gataaaatct ctcgcttctg gaatgcctgg 1607941 atgataatac agctggtttc cataggcggc aacccaatct ggatgttttc ttgccgggtg 1608001 atcctcagac aatttattaa gatctgtatg attcattgta atacggtaag gattaaacca 1608061 cgcgtgaaat tccaaatttc gtttatgggt ttcttcaatc ataaatgcaa gaggatcata 1608121 gccggggtcc ttcccttgga caccggttaa gtattccgac caaggcccgt aagctgacgg 1608181 ataaaaggca tcagccgtcg gtttaatctg aacgataacg gcattcattc ccattttttg 1608241 cacatcgtcc agcagtttga tatactcctg tttttgctct ttcacagata accctttttt 1608301 ggacggccaa tcaatattta atacggaagc aatccatacg gctctcagct ccctgtcaga 1608361 ctgcgcattg gccataaacg gaacggaaat gacaaacgtt ccgatgatca agctgacaag 1608421 gaaacggaca atcgactttt ggcaaacctt cattctgttt cttctccccc attacatcac 1608481 tttcactatt cgctattacg gtattcccgg gctataaaag ggtgattaac agaatgtcta 1608541 tctcactaaa taaacgaaaa aagtcctaaa gcatgttgtg aaccgctttt aggacttttt 1608601 atcattcatc atggtttgca gactttttaa cacatcaata agttttacgc cgacaccgac 1608661 agccgtttca aggatcgctt gtgctccggc aatggctaaa ataaagatca gcggtattgc 1608721 aatacgaggc aaaaaaagat agccaagtcc gatcaagatg gcacaccaaa caccggcaca 1608781 ccagtagcaa ttgagcatgt atccaaagtt agaagccggc acgctttttt catctacatg 1608841 cccgttttga tcaacaatcc ttttcttttt cataaaaggt tttcggataa attctgtgat 1608901 tttgtcaaat acaatcaaat gtgtcagcct gtaactggct agaatcagca tgataaaagt 1608961 tagaaaagaa agacggtcca ttgagaagcc tccaagaaaa aggatgatgt tatcattccc 1609021 aagtgtccct tatccattct tgatacaaaa agaaagacgg acagagaatg gcctctgtcc 1609081 gctaatccga gctcattccc tccagttctc ataataagag gataagaaaa tgtagaaaaa 1609141 agcagaaaaa tgacaataaa agaaattata tgactatata atccatatat gcactatatt 1609201 aacggatatt ttttaaagta caataaaaaa cattaaattt ttataacatt ttttttgaat 1609261 atagtattat ttctttattt ttcgtttctt tttttatcaa atttccggat ataaagtgat 1609321 aaaagtattg ttttacataa ggtcttatac actacttttt aatcggacta attttctttt 1609381 gtgcatcatt cttctaattg ttggaaggtt cgacaaagcg ttattacaga cataaaaaaa 1609441 cctgttttct cttggaaaac aggtctcccg ctattattga tttgccaaaa tgacagcgat 1609501 ttgatcctca atatcttttc catcctcttc atcaatcaat ccatttagaa gaatagagaa 1609561 aacaagtttt tttccgctct ttgtttctgc gtaccccgat agagagctta ccgtactgag 1609621 cgatccggtt tttgctctta cttttccttg tgcaggagtg cctttcatgc ggtttctcag 1609681 cgttccgccc accattctgt caggattccc cgcaacaggt aaagaattta gataagccga 1609741 gaaccaactc tgatcctgaa tgtcatataa cagctgtgaa agttgatctg aggatacagc 1609801 atcaatatgt gagattcctg atccgtccct taagacgagt gatttagaat caacaccaaa 1609861 ttccggaagc gtactgttta acacttcgag ccccttttcc cagctccctt ctcctttttt 1609921 cactttcccc atctctttta cgagcacttc ggcatgtccg ttattactta atttcatgaa 1609981 cggcacaaaa agtttcgata aaggcattga gcgatgagag agcagcacat ctgaagaact 1610041 aggtgcttca cccgtcttga tgtccccttt cacagtaata ccttgttttt ttagtgactg 1610101 cttaaataaa tctaaggcat atccggcagg ctcccagaca gaaatccatt cctttgtctt 1610161 gtttgcgtca accggtacgc tcccttcaat tgtaatcgtg tttgttccat gctctctttc 1610221 gattgtgagg tctttctctg aaccggcagc agtcgtttta gcatcgttct ttatcgttat 1610281 ataatcggtt ttcggagaga cagacacggc aggctcttcc ccttcttttt gatttggggt 1610341 gacctcaaca atcacagtgc ctgcatcata gtcttcgttt ggagacgctg ttagagcgga 1610401 gattggcgcg ccataatatg tgtattcatc gctccaaggc atatcaggtg ataatcgcat 1610461 gtcatcatgc cacgtatcat caccgatcag attgccttta attactttta cgccggaatg 1610521 tttcaatatc tcagccattt tgtcaaaatc agatggtaaa agtgtcggat cgcctttccc 1610581 tttcaaataa aggttaccat tcagcttttt ccctttcagt gttccatccg tccggacctc 1610641 ggttgtaaaa gaatagttct cgccaaggac agaaagtgcc gcggccgctg tcaaaagctt 1610701 tagagaagag gcaggcctca ttcgggtgtc tcctgaatgt tcatatagaa cagcacctgt 1610761 ttccgcagag cgaacggtga tgccggccat tgcgccttcg agggcaggat gatcagctaa 1610821 aatcttatcg atctgcccgg aaagtgcatc ttgtttttca gcggcaagcg cagcctgatg 1610881 catataaggc accgaagcaa cgacgaaaag cagtaaaaca gcaacataaa gctttatgct 1610941 ttttttcatt aatttccccg cctctctgcg cttcatcatt ggctattgat gattcagttc 1611001 aatggtgata ctgcttttag ctgtcgtttc ttctcccggc tccagcactt gtaaaccagt 1611061 gagtgacgaa ggtaaatcaa gattcactgc gtttgtcacc catgtgtaag gctcagggca 1611121 taaataccct tgttttccgt ccgcattgta tacaacccaa tgtttaaact gttcatctgc 1611181 cttataaata atgctgatat gtgcatgctg atgataaatg actgcctggt tttctccgcc 1611241 cctcttctga taagaagata aaaagacatc atccagctgc ttgtggcgca aatccattcc 1611301 ttcatgcaaa gcttctttat acgggacatc catcagcttc ccggtcggca gcaggcgttc 1611361 atccaactcc cattgctgat ctgctgtcag ggagaataac gagctttctg ccggaaatat 1611421 aaatgtagta tgataaccaa ttccccaagg aaacgcttcc tttcctttgt tcatgaccgt 1611481 cgcatgttta aatagggtat tctccttgat cgtgtatgtc atccgaacga cggcatgatg 1611541 aggaaattgc ttctgcacat ggggaagctc agaaagatca atttctgttt caacaatcac 1611601 tccttcatca gtttgcttcg tggtcacgac attccacttt tcatggtaaa gaaacccgtg 1611661 aagatggttg tgtttatcct tctcgttgat atcaaaatga tacgttctgc cccggaaact 1611721 gaatgtaccg tcacttatgc ggttaggcgg gaacaggatt ggaatgccat acaatgttgg 1611781 tgtgtcgtga aaactttctg ctgtttccgg ttcacgcaaa agctggacat ttgttgtttt 1611841 gtccacgaga gaaatgacgt tgctccccca ctcagggaca acaatcattt ctagatgttc 1611901 gttgcccgct ttgatggccg gcgttcccaa atacgtgatt ttctcaataa agtttgccat 1611961 gtttactcaa cctctccttg attcattgct agtataagaa ttcaatgtac tgtaccatat 1612021 ttcctccatt ttatattttc ccctatcaaa taaaaaaaca ccgttcaaac ttatgaacgg 1612081 tgtgattcgg aggctattgg atgagacgtg tgatttgttt ctttttccag acgaattgat 1612141 aatacccata aatcaacagc aagctgacgg caaacgcagc tggataacca acccagacgc 1612201 cgagtatttc aagctttgta tagtgagaaa ggacgaaagc gacaggcacc tctactcccc 1612261 agattgcaaa aatactgatg acggtcggcc ataaaactgt tccgcttgcc cgcatcgttg 1612321 cagaaataat ttgggcattt ccaaacagca aatagctcca cagtgtaatc atcaaaagac 1612381 ggtgcgcaat gtaaagcgtc tcttgctcgg ttaaaaataa cgataaaatc tgatgtgaaa 1612441 aaacatagat cagaatgatc agtacgccgc caatgatata attcagccaa atcccaacgc 1612501 gaatgacctg ctttaagcgg tcaaactcgt ttgctccgat cgattgcgca gcgaaaatag 1612561 aaaccgcaat accaaggctg acggccggca tctgtacata gctggccacc tggttgacca 1612621 ctccgtatgc agctgttgca ttagagccgt aatgattgac gaatgaaata accgctatct 1612681 ctgataatga gacaagaatc atattgatgc ttgctgggac cccaagacgc agcaggagaa 1612741 ccagcagttc cttatccatt ttcaaataac gacgcactgt tttatcaaat tgcagcgggt 1612801 gttttcgctt tcgtaaatac accattaaca cgagaaaagt cgcaatcgtg gaaatgacag 1612861 ttgcatatgc cgagccgtat atgcccagtt tcggaaaacc aaacatgcca aggattaaaa 1612921 caggcaaaag cgcgatgttg atgaccgtgc tcacaatcag cgtataaaac ggtgtcttgg 1612981 aatctcctgt tccgcgcaaa aaggtagtat atgcaaaata taaaaacata aacggcatag 1613041 cataaaataa aatacgtgca tagttagcgc tgacatgaat gacattttca ggtgttccca 1613101 ttaaacgaag gatatccagg gtgaaaatac tgccgataac ggctaacaca acgcctaata 1613161 aaaatgtaaa cgtgagtgtc gtcccgacaa cagcctttag ccgttcctca tttttcgctc 1613221 cgtaagcttg tcctatcaga atcgaacttc ctgaaccgat cccaatcgta aatgagatta 1613281 aaagaaaaaa taacgggaaa aaggatgata cagctgccac tgcatcaaca ccgagccatc 1613341 tgcctacagc catcatcccg actagctggc cgactgattg cagcacattg ctcagcagaa 1613401 gcggcactaa aaagagtgac atcgaccgcc aaactgatgg tttgcttttc ttttgagtta 1613461 caagaggttc ttgtgatgtt tccatattaa aggactcctt tatttgaaat cgtttttaaa 1613521 catgccctca ttttttgaca aaaacaggat atgtaacatg ttattattca tcactgcact 1613581 tatgaaaccc ttcccgattc ttctaatttt acacatcttt ttagcttatg aagaataaac 1613641 tagcaagtaa tggcgtattt tttgtgagta aaagaataaa aaataattta tgcaaaagta 1613701 ttgtaatcta tccgtaatta ttgtaacatt tgtaacataa gagaaagaga ttttgaagga 1613761 gagagcgata atgaaaaaat gtcttctatt tctaacaacc attgcactta ttctgtcatt 1613821 aagcacaaat gcatttgcga aaaatacatc aggcgattta tcacaaaaac aagcattaca 1613881 gttggcatta tccgctagag aacatttttg gaacaccatg agcggccaca atccgaaggt 1613941 gaaaaaagca gtttgcccat caggcacatt cgagtatcaa aatcttcaat atgtatacat 1614001 gtgcagtgat ctaggcacta aagcaaaagc ggtgaattat ttaactccta tttttacaaa 1614061 aacagcaatc gaaaaaggct ttaaagatta tcatttcact gtttcaaaag gaaaacttgc 1614121 tgttccaatc ggtgacggag acaatctttt gaattggaaa aaatcaactg ctaaactgat 1614181 ctctaaaaaa ggcagcacaa tcacatacga atttactgtc cctacattag acggatcccc 1614241 ttctgcaaaa cggaaagtga catttgtgaa agaaaataaa aaatggaaag tcaatcaatt 1614301 tgacgcagtt atataagaaa aacgcccggt ataagcgggc gttttttatt tggtttgcat 1614361 aaagaaagac aacaggcgaa aagtgcctgt tgtctttttg tgaatataac gctctaggag 1614421 agattcgaac tcccgacctg cagtttagga aactgctgca ctatccgctg tgctactaga 1614481 gcttttggta tttatatagt agctctgatg atcaatattt tcaagcgatt tgtattaaag 1614541 ccctccaaaa accttatatg cggctcttgt cgtatcttca tcaataccga tataccgcat 1614601 tgtaattgat ggtgatgaat gattcagtat tctctgcagc tcggcgatgt ctttcgttcg 1614661 ctgataaaaa tgatagccaa acgttttccg gagtgtatgc gtccctatct cctcaagtcc 1614721 gcacgctgca gcggcctctc ttaaaattct gtaggcctga atgcgggaaa tcggcttcct 1614781 ggtccgcact gatttaaaaa gatattcgtt ttccttcatg tctttcgtat actcgtatat 1614841 ttcctgtttc agcgattcta aaataagaat ctttcttttc tttttcgttt tgctttcagt 1614901 cgcccataaa tgatctttat tttgaacgtc cttcacttgc agcggcagaa tatcagaaat 1614961 acggagcgcg ctgttgatgc cgaaaataaa cagaaaataa tcccgcttgt ttttgttaag 1615021 caaatactgt ttgacttctt ggattttctc tagactgcga atcggctgta caatatgcat 1615081 caaaaaactc cttaaaaacc gttatgtaac attttgaggt ctatgttact attatagctg 1615141 aaaaacgttg aatgtcaaag tgcggcggcg tttatgtaac ataatataca tagtgttaca 1615201 taagctttta aaaaagcttc ttccaacctt caccctataa aataagcttt aaagcctctt 1615261 ataaagcttt taacctcttg gatacttatc cccctactaa tcatcaaaaa acctcttaaa 1615321 atgaaatctg acactcccaa ttttctggag cttccgcaaa aatatacaaa aaaagacaca 1615381 atttcaaatt gtgtcctaat cctcatcctt tacatcaata tcttccggga tcggttcatt 1615441 taatatttcc tgcacaagtg ctttgtaatt ctccagctgt tcgagatgcg ttttgaactg 1615501 ttccttataa atcaaaaatt gctccccgtc atgaacggct ctgattttcc cttcgagcac 1615561 caagctttta atataatcct ctgaaagatt tgtatattct gctgtttctt caatcgttaa 1615621 atacatatag cagtcccttc ttaatccgta tgctgattct aatatagcac atggctcata 1615681 tcaatataat caattctgca cagaaaaacg gcattatgca ctatataata taccatttgt 1615741 cacttgtgaa aacgctgtaa tttttttacg ctaagattgt aacaatacag cttcatatag 1615801 gagggagaac atgaaaagaa cgtggaacgt ctgtttaaca gctctgctta gtgttctgtt 1615861 agtcgctgga agtgtccctt ttcacgcgga agctaaaaaa ccgcccaaaa gctacgatga 1615921 gtacaaacaa gtagatgttg gaaaagacgg catggttgcg accgcacatc ctcttgcttc 1615981 tgaaatcggt gctgatgtgc tgaaaaaagg aggaaatgct attgacgcag cggttgccat 1616041 tcaatttgca ctcaatgtaa cagagccgat gatgtcaggt attggcggcg gcggttttat 1616101 gatggtgtat gacggaaaaa cgaaggatac aacgataatc gacagccgtg agcgtgctcc 1616161 agcaggcgca actcctgata tgtttctgga cgaaaacggc aaagcaattc ctttctctga 1616221 acgtgtaaca aaaggtactg ccgttggtgt tccaggcact ctgaaagggc tggaagaagc 1616281 cttggataaa tggggaaccc gttcgatgaa gcaattaatt accccttcta ttaaactcgc 1616341 tgaaaaaggc tttccgattg attcggtgtt ggcagaggcc atttctgatt atcaggaaaa 1616401 gctttcacgg actgccgcaa aagatgtatt tttaccaaat ggcgaaccgc ttaaagaagg 1616461 agataccctt attcaaaagg atttggctaa aacatttaag cttattcgct ccaaaggcac 1616521 tgacgctttt tataaaggaa aattcgccaa gacgctttct gacactgtcc aggatttcgg 1616581 cggatcaatg acagaaaaag atttagaaaa ttacgacatt acaattgatg aaccgatttg 1616641 gggagattat caaggctatc aaatcgctac tactcctcct ccaagctccg gcggtatttt 1616701 cttattgcaa atgctgaaaa tccttgatca ttttaacctt tcacaatacg atgtccgctc 1616761 atgggaaaaa tatcagctgc ttgctgaaac gatgcatttg tcatatgccg accgtgcgtc 1616821 ttacgcaggt gatcccgaat ttgtaaatgt tcctctcaaa ggcctgcttc accccgatta 1616881 tattaaagaa cgccagcaat taatcaacct agatcaagtg aataaaaaac cgaaagccgg 1616941 tgacccttgg aaataccaag aaggatcagc aaactataaa caagttgaac agccgaaaga 1617001 caaagtagaa ggccaaacaa cccactttac agttgctgac cgttggggaa atgttgtttc 1617061 ttatacaaca acaatcgaac agctattcgg aacgggtatt atggtccctg attacggtgt 1617121 tattttaaac aatgaattaa cggattttga tgcgatacca ggcggagcta acgaagtaca 1617181 gccaaacaaa cggcctttaa gcagcatgac cccgacgatt ttatttaagg atgacaagcc 1617241 tgtcctcacg gttggatctc ctggcggggc cacaattatt tcatccgttt tgcaaaccat 1617301 tctctaccac attgaatatg gtatggaatt aaaagcagct gttgaagagc cgagaattta 1617361 cacaaacagc atgagctctt accgttacga agacggagtt cctaaagatg tcctcagcaa 1617421 gctaaacggc atgggccaca aattcggcac aagtccggtg gatatcggaa acgtgcaaag 1617481 tatatcgatc gaccatgaaa acggcacctt taaaggtgta gctgattcaa gcagaaacgg 1617541 cgcggcgatc ggcattaatt taaaacgtaa ataaataaaa aactgtactc gcttcaaatg 1617601 agtacagttt tttcatgcag atctttaaaa taaaaactga caaacgtctt tattctgcta 1617661 atgcacgtct atcttcatct tttcatttcg tttatctcat caagaaatgt ctgaaacgca 1617721 ctcgtaataa aaaagtcttt cctgtatata aagacgatct ctaagtcttg atatgatggt 1617781 ggcagctgat gaatccatac atttgtacga tgctcggagc cgtcaacagc ggactttggg 1617841 agcagcgccg tacccatccc ggcggaaaca ccttttataa tagcctccaa tgtgccaaac 1617901 tctatgattt tttgattgtg tatgcctgct tcctctagta atcttttgac cctgtcacga 1617961 tgagaacagc cagccccaaa aaagagcatc ggctgctgaa gcatgtcttc tgccgtccct 1618021 tctcgtgatg aaatcaaaac taattcatca tgggagacat ggagttgtct aactgcagcg 1618081 tgttcaaccg gcccatatac aaaagcgcca tcaactttat gatcaagaac ctgttgaatc 1618141 aaatgatgcg tatcagctgt gttcactgat aaatccactt caggaaaacg cctgaggaag 1618201 gatgctgcat gctcaggcag atgcgttacc gccattgttt ccagtgatcc gatccgcaaa 1618261 ggcccttttg gttgcctgct cattcgggtc gatttttcag cttggtctaa cagcgataat 1618321 acttgatctg catattgtaa aagattttct cctgcagcag tcagcttcat tccccgattc 1618381 gttcgatgaa aaagcctgat attcaaatct tcctcaaggt tatgcactct ggctgtcaca 1618441 ttcgactgaa cataattcag catttgggct gctttcgtta tgcttccttc gcgagcaaca 1618501 gcctgaaaaa tctttaaatc tccgctttcc acgcgctctc acctgcttgc tatgatgaaa 1618561 agtgatattg gctatcatat ttgttcattt tactcgaaga aaaccgctat gtaaaatatg 1618621 taaagatatg aaaatacaat taatgaggag gcagacagca tgaaagctgt aattcacaac 1618681 ggaaaagccg gtcttctggg gttatcagtt caggacgttc catcaacaaa gcctggatac 1618741 ggagaggtaa aggttaaatt aaaatctgca ggcctgaatc atcgtgactt gtttcttatg 1618801 aaaaacaaat ctgaacaaga tcctcacatg atactgggtt ctgacggcgc gggtatcatc 1618861 gaagagattg gtgaaggcgt gaaaaatgtt actgttcaga cagaagtagt cattttcccg 1618921 acattgaact gggatttgac agaaaatgtt ccacctgtac ctgagattct gggaggtcct 1618981 tcggacggaa cacttgctga atatgtgatc attccttcac aaaatgcaat caaaaaacct 1619041 gcttatttat cttgggaaga agcgggcgtt ttacctttat ccgctttaac tgcatatcgg 1619101 gctctgttta caaaggggca attaaaaaaa ggcgagcatc tattgatacc cggcatcggc 1619161 agcggtgtag caacctacgc tttatttatg gctaaggcga ttggggcaac agtaagcgtg 1619221 acctcccgca gtgaggagaa aagaaaaaag gcgctgaaat taggtgctga ttacgcattt 1619281 gacagctaca gcaattggga tgagcagttg cagggaaaaa agatagatgt tgttcttgac 1619341 agcataggac ctgccctctt ttcggaatac ttccgccatg taaaaccaaa tggccgtatt 1619401 gtcagctttg gggcaagctc aggggataat ctcagttttc cggtgcgttc tttattcttt 1619461 cctcaggtca atgttttggg aacctcgatg ggaagcggtg aggaatttca agctatgctc 1619521 gctttcattg acaaacataa gctgcggcct gtaattgacc ggatatatcc tttagaaaaa 1619581 gcatgtgaag catataaaag aatgcaggaa ggcagacagt ttggaaacat cgggatcgta 1619641 atggaataaa aaaagaaacc ggctggcagc cagaccggtt tctcttatat gataatcccc 1619701 tttatttacg gaagaactga actccccatc aaatatcgat ccacttcacg cgccacttca 1619761 cggccttcat taatcgccca tacgattaag ctttgccctc ttcttgcatc ccctgcggcg 1619821 aatacaccat cgatatttgt ttgataatcc ccatatgctg cactgatttt gttatttact 1619881 gaattaacac cgaactgttt caacagcggc tgttctgtgc cttcaaagcc gatagcgata 1619941 aagacaagct gagcaggcca tactttttcc gttccaggca gctcgcggaa ctcgtatttt 1620001 ccatgctcat ttttcacttt ttccatttgg atggtatgaa gctctttcag ctttccgttt 1620061 ttatccgcga ccatttttgt cgtttgaatg gagtattctc tcggatctct tccgaatttt 1620121 gcttctgctt cctcgtatgc atattcaagc gtaaagacgt gtggctgttc aggccacata 1620181 ttgtcattcg tgcgggctgg cggaagtttc gggtgtttgc cgaattggtg cacgcttttg 1620241 gctttttgac gcagagcggt agccacacag tcagctcctg tatctccgcc tccgattacg 1620301 atgacatctt tccctttggc atcaatgaat tgcttgtctt taaaattaga atctaaatag 1620361 ctttttgttg caagtgtgag gtagtccatt gcgtaatgga ctccttttga gtcgcgtcct 1620421 tcgattaaga ggtcccgctg tttttgagcg cctgtgcata agatcacagc atcaaattgc 1620481 tcctttagct catcagctgt aatgtcaaca ccgatttctg tgttcgtgac aaaatcaatt 1620541 ccctcttgcg tcagcaattt aattcggcgt tctacaatgc ccttctcaag cttcatgttt 1620601 ggaatgccgt atgttaaaag gccgcccgct ctgtctgctc gttcaaaaac agtgacggaa 1620661 tgtcccgctt gattcagctg gtcagcactc gccagtccgg ctgggcctga cccgacgatg 1620721 gccacttttt tgcctgttcg tttttttgga attctaggtt gaatccagcc gttctcaaat 1620781 cctttatcga taatggtccg ctcgatgttt ttaattgata cggccggatc tgaaatcgct 1620841 aaagtgcatg atccttcaca aggagcgggg catacccgcc ctgtgaattc aggaaagttg 1620901 tttgttttca acagacgttc caatgcttcc ttccatctgc cccggtagac aagatcattc 1620961 cattcaggaa ttaagttgta aatcggacag ccggatgtaa atccgttaat gtccgcaccg 1621021 atctggcaaa acggtgtacc gcaatccata caccgcgccc cttgccgttt cgatgcttct 1621081 tctgaaaaag gagcagaata ttctttccaa tcctttaagc gagtgagagg gtcccgctcc 1621141 gcaggttttt ctcgtttgat ctccataaat ccagttggtt tccccatgtt cctctcccct 1621201 tccttactgt actaccgctt gtttttgtcc cgatgctgct gtattctgct ttggcttcgt 1621261 gttggcctca aaagcgaaca tgatggcttc ttcatctgat aaacctgcag ctttttgctc 1621321 ttcgatgctt gcgagcattt gtttatagtt tttcggaatg actttgacga attttttcac 1621381 actgtcttcc cattgatcta gcagatcttc tgctttttgg ctgtttgtat acgcagtatg 1621441 tctttcaagc attgctttga tttgctggat ttctttctca tcctctaatg attcaaataa 1621501 aatcatctca aggttgcatt tgcgtttaaa cgctttgaca tcttcggtca gtacataagc 1621561 gattccgccg gacatacctg ccgcaaagtt tttgcctaca tcaccgagaa cgacaacgct 1621621 gccgccagtc atgtattcac agccgtggtc gccgatgcct tctacaacta cgttcacacc 1621681 gctgtttcga acggcaaagc gttcaccagc acgcccgtta atatatgctt ctccgcttgt 1621741 cgcaccgtaa aaagccacgt tgccgataat gacattgtca tccgaagcag agttgaatcc 1621801 ttctgatgac ttgacgatga tttttccgcc agaaagccct tttccgacgt aatcatttga 1621861 gtctccgtcc aaataaagcg tcatcccttt aggaacgaaa gctccaaagc tttggccggc 1621921 tgatccggta aagtgcagct tgattgtatc ttcaggaaga ccttcttctc cgtaacgctt 1621981 tgagatttca ctgccggtta tcgttccggc tacacgattt gtattattga tttcaatcga 1622041 aatatcagct tcttttccag attcgatggc ttcttgtacg gccgggagaa ttgttgtaat 1622101 atcaagtgat tgatcaattt tatgattttg cggcgattgg aacgtccgca ccccttcagg 1622161 ctgataaaga agggtagaca aatcaagctg gcttgctttc cagtgctcct ttgcccgttc 1622221 acttgcatga agtacatcag tgcggccgat catttcatca aatgtcttga agcctaacgc 1622281 agccatgtac tcacgaactt cttcggcaat gaacagcata tagttcacaa tatggtcagg 1622341 atctcccatg aactttttgc gaagctctgg attttgtgtc gctacaccga cagggcatgt 1622401 atccaaatgg caggcacgca tcatgacaca gccgagtaca actaacggag ccgttgcgaa 1622461 accaaattct tcggcgccga gcaaggcagc catcacaacg tcgcggcccg tcatgagctt 1622521 tccatctgtt tctaatacaa cacggtcacg aagtccgttc agcattagtg tttgatgtgc 1622581 ttctgcaagg ccaagctccc acggaagccc tgtatgttta atactggttt tcggagaagc 1622641 gcctgtacct ccgtcatagc cgctgatcac aatgacatct gcagtcgctt tggcaacacc 1622701 tgcagcgatt gttcctacac ctgcttttga caccagcttt acgctgattc ttgcgtcacg 1622761 gttggcattt ttcaaatcgt ggatcagctg ggctaaatcc tcaatcgaat aaatgtcatg 1622821 gtgtggcgga ggtgagatta atccgacacc tggcgttgac ccacggacat cggcaaccca 1622881 tggatatacc ttgttgccag gaagctgccc gccttcaccc ggcttagcac cttgagccat 1622941 tttaatctgc agctcatcag cattgacgag gtaatggctt ttgacaccaa accgtccgga 1623001 tgcaatttgt ttgatcgcac ttcttctatc atcgccgttc tcatctggaa caaagcgttt 1623061 gggatcttct ccgccttcac cgctgttgct ttttcctcca agacggttca ttgcgattgc 1623121 taaagcttcg tgcgcttcct tactcaagga cccgaatgac atcgcacccg ttttaaaacg 1623181 tttgacaatc gattcagcgg attcaacctc ctccaacttc aaaggcttgc ggtttccgtc 1623241 aaatgcgaac aagttccgca aaaatccgat gcgttcttca tcagccgctt ttgtatactg 1623301 tttaaacaga ttgtaatcat ttctgcggca cgcccattgc aaagtatgaa tcgttttcgg 1623361 attaaacgca tgatgctctc cgccatttct ccattggaag tcacttcccg gttcaagcgt 1623421 tttgctgtaa tcatcctgat acgcttcccg gtggcggcgc tgtgcctctt ctgcaattgt 1623481 ttgtaaatcg atgccgccta gctgtgatgc agtacctgag aaatagcggt cgatcacatc 1623541 gcggctgatt cctaccgcct caaagatttg tgcgcctctg tagctttgca cagttgaaat 1623601 tcccatcttg gacatcactt ttacgacgcc ctcagtaatg ctttttccat atttgctaac 1623661 cgcttcttca tagctgatat ccaaacggcc ttcatcaatt tcctgcttgt aggtcgcata 1623721 agcgagataa gggttaatcg catctgcgcc ataaccgatt aacgctgcaa agtgatgcac 1623781 ttcacgtgct tctcccgatt ccacaataat gctgaccttc gtacgcagcc ctttgcggat 1623841 taagtgctgg tgcagtgcgc ttactgccag aagcggcgga attggtgtca gtcgttcgtt 1623901 catctttttg tctgataaaa ttaacaaact tacgccttgg ctgatggctt tctctgcctg 1623961 tgtgaacatg tcctttaaac cgcgttcaag atcctctgaa aacagcacat caattttttg 1624021 gctttttaaa tcaggatgaa caatcgtttt caatgcgtaa aactgttcat tggataaaac 1624081 aggtgtatac agtttaatcc ggcgaacatt tcgttcactt ggatgaagaa gatcgccttc 1624141 cgcaccgagc caagtcatcg ttgaagtgac aagctgctca cgaatcgcgt cgattggcgg 1624201 gttcgttact tgtgcaaaca gctgtttaaa gtagttaaac agcgattgcg ctcggtcaga 1624261 aagtacagca agcggagcgt cattccccat tgaaccaagg ggatctttgc cttctttaat 1624321 aacaggaatt agatactttt ggatatcctc atatgtgtat ccgaatgcct tctggcgagt 1624381 aagaagatca ctaaattgtt cttcttctct tgactccgga tcaggattta cttgtacaag 1624441 ctcttcttca agccattttt ggtacggata ctcagttgca atttgtgttt tgacttcctc 1624501 atcggagata atacggcctt cttccaggtc gattaaaagc attttcccag gctcaaggcg 1624561 gtttttatat aaaacgttct cctgttcaac ttcaataacg cctacttcag atgagaaaat 1624621 aatataatca tcttttgtga cataataacg ggccggacgg agaccgttcc ggtcaaggat 1624681 cgccccgatt tgtttaccgt cagtaaatga aatagctgtc ggtccgtccc aaggctccat 1624741 cagggagcta tggtactcgt agaacgccct tttttccttg gacatatgcg tattttccgt 1624801 ccaaggctct ggaatgagca tcattgccgt atgtgccggt ttgcgtccag ccatcacaaa 1624861 aaactcaaat gcgttatcca aaatggaaga gtcactgcca tcagcattga gaatcggcaa 1624921 aatcttgttt aagtcctcac cgaagctttc agaaacaaat tgctgctcac gtgctctcat 1624981 ccagttgata tttccgcgaa gggtgttaat ttcaccgttg tgaaccaaat agcggttagg 1625041 atgcgctctt tcccatgtag ggaatgtatt ggtactgaag cgtgaatgaa caagcgcaaa 1625101 agcagaaacg aatgcttcgt cttgcagatc agaataaaat gcatcaacct gttcaggtgt 1625161 taaaaggcct ttgtaaacaa tggtctggct tgaaagactg gcaaaataaa aatcaagacc 1625221 ttccgttact ccccaatttt cagcctgttt acgaatgaca tacaattttc gttcaaaaga 1625281 taaattgtcc tttagatcag aacttgcgcc gataaatacc tgacggacaa acggacagct 1625341 tttttgcgcc actgttccga tttttccgac atttacaggt acagttctcc atccaagaac 1625401 gacttggcct tcttgttcaa ttagtgcatt gatttgcttt tcaatttttt ttctttcatc 1625461 ttccttctgt gagaaaaaga ccattcctac cccgtaacgt tctttttctg gcagattgat 1625521 gtttttgcac tcttttctaa agaaagcatc agggatttga accagtaagc cggctccgtc 1625581 tcctgtatcc ggatcactgc cttgccctcc tctatggtct agctggcaaa gcatcttaag 1625641 tccttgtttg acaatgtcgt gagtctgctt gccctttaag tgtgcatata ggccgattcc 1625701 gcatgcatca tgttcaaatt caggacggta gagaccttga gcttttggca tttgattgta 1625761 cgtcataatt cctctccccc gatcaatttc cgataatacc ggtcataaaa tctaacaact 1625821 ctataatcat tgtaggtttt caaaacgata taaacaatat ataatttaga tcaaaagaat 1625881 ctcaaaatga gatagatgga tgtgagacaa acatggagct gcgccaactg cgttatttta 1625941 tggaggtggc tgaaagagaa cacgtttcag aagccgctga tcatttgcat gtggcccaat 1626001 cagcaatcag cagacaaatt gccaatcttg aagaagaatt aaatgtgacc ttatttgagc 1626061 gtgaagggag aaatatcaaa ctcacgccaa tcggaaaaga atttttaatt catgtgaaaa 1626121 cggcgatgaa agccattgat tatgcgaaag agcaaattga tgagtatctt gacccgcatc 1626181 gcggaacggt aaagatcggc tttcctacaa gcctcgccag ccagcttttg ccgactgtca 1626241 tttcagcgtt taaagaagaa tatccgcacg tcgaattttt gctgcgccaa ggctcctata 1626301 agtttctgat tgaagctgtc agaaaccgcg atattgatct ggccttatta gggccggtgc 1626361 cgacgaattt ctctgacata acgggaaaaa tattatttac tgaaaaaatt tacgcgcttg 1626421 ttccattaaa tcatccgctt gctaaacaaa aaacggttca tttaatcgat ttgcgcaacg 1626481 accaatttgt attgttcccg gaaggatttg tacttagaga gatggcaatc gatacttgca 1626541 aacaagcagg ctttgctcct ctcgtttcca cggagggtga ggatttggat gcgatcaaag 1626601 ggttagtgtc cgcaggaatg ggcgttaccc ttctgcctga aagtactttt gctgaaacaa 1626661 cacctcgttt tactgtgaaa attccaattg agttccctca agtaaaacgg actgtcggaa 1626721 tcattaaacc gaaaaataga gagcttgcgc cttccgcgaa tgatttttat gagtttgtca 1626781 ttcaattttt ctctaagctg gagcagtatc aataaaaaaa atgaacccga gcttctatat 1626841 agaagcttcg ggtttttttc tgcaaattaa tttacaggta aagaaaaatc cacatggcaa 1626901 acaaatgctt cttgatcaat tagagctcta tttgtcagtt cctttttctt ttccggttct 1626961 tgaagctgta cagaagagta attgacgatt ccaaggccga tttccgtccc ttttgaatcc 1627021 atcagccgaa caactgaacc gcttttgaat ttccctttaa tcttctgtac accgtctagg 1627081 tataaactcg attgtccgtt tgttattttt cgtgaacaat catctgataa aatcatttca 1627141 ccttccggac cggaattaaa agcgatccat tgctcctttt gattcaacgg aagcgttcct 1627201 tctgcttcaa aataggtgcc ttccgcctgt tcatgaacgg cgtggtataa aatatcgcca 1627261 gcatctgcct gacctaggaa acctttaatg ccagacgcca ttacgatttt aaacgcatca 1627321 agcttagagc gcatgccgcc ggtgccaacg atgcttccag tgtcacctgc gcatgcttcg 1627381 atgtcaggtg ttatttcact cacccgctgt atctttttcg cttctggatt tgtgcgcgga 1627441 ttgccgtcat ataatccgtc tatatctgat aaaatcacaa gcatatctgc atcaatcaat 1627501 cctgcgactt ttgctgcgag cgtatcattg tcgccaaact tgagccgatt gacggtaact 1627561 gtgtcatttt cgtttatgat cgggatgatg ccgcgctcga gcagtacatt cattgtattc 1627621 ctgacattgt tgtatcgata ttcatcagaa aaatcgcttc tcgtaattaa aatttgggat 1627681 gcgacatagc cgtgtgccaa aaacagcttt gaataagcct ccattagcaa tccctggccg 1627741 attgaagctg atgcttgttt ttctggaagc ttctcgggcc tttggataaa tccgagcttc 1627801 cgatatcccg ccgccactgc gcctgaggaa accaaaatca cttcataacc ggcgtctttg 1627861 agtttgacga cctggtcgac caacgcttct aattttcgaa tgctgatttc tccatgaagg 1627921 cttgttaatg aactgcttcc aatcttcaca acgactcttt tcatgcttgt atcaggcgtc 1627981 actttatcac tcctgatagc ggcgctgcag ttttttcgat atcttcgctg atttcctttg 1628041 aacgcttagc cgcatgcttt attgcttgag aaatcgcttc tccgccgccg ctctttttca 1628101 aggcttgcag ccccgctgct gtcgttccgt tcggtgacgt gatattatct cttaagatct 1628161 caggatgttc tcctgtttcc atgagcattt ttgcggcacc taaaagtgtc tgtgcgccga 1628221 tgcttcgaga taactgttta tcgaggcccg cttcctcgcc tgtcttttca atgaattcca 1628281 ttaaataata aaaatacgcg ggtccgctgc ctgcaattcc ggtgaatata tccatttgat 1628341 tttcttggat tgtatagact tcgcccatgc atccgagcaa tgcttcggcc agcttcttca 1628401 ggtcttccga cacatatttg ccaagggcaa tagctgttgc agaagcgcca atcatactgg 1628461 aagtgttggg catcactctg acaaccggct gttcattaag caatgattgt tcaataaaag 1628521 aggtagttat gccggcaagg accgacaata ttaattgatg gggttgaata cgtgatttta 1628581 gtgatgacag agcgttttcg gcgtcttttg gcttcattgc caaaatgagc acatccatgt 1628641 cttcaataca tagttggttc ggcaaggcgc ctttaatgcc atattgaagt tcaagttcag 1628701 ttaatcgctc tgtattgctg cggtttgtaa cgcagatgtt ttgtttcggg attttgttgg 1628761 ctcgaacgat acctgatatc attccttccg ccatagatcc tgctcctata aaggctactt 1628821 tcttttgatc aaagatcggt aacatctcct ttgttcgctt ttttgttcgc attttcacac 1628881 gtttaaaatg ttaccacgtg aggaaatgat gtcaagtttg aaggccatta ttgatttgta 1628941 ttgtttcttt tcgacaaata tgtataatga aaagcagaaa acacccggtt cacactgctg 1629001 cgccgggtgt ttgtttctat taaaaattat ctgagagagc tttttcaatc agttttttac 1629061 agcgatccag ctctaccttc agctgttttt tatatagctt ggcagcttcg taatctttaa 1629121 attgatagag gacgacttcc tggagcttag ccccttcttt ttttacttta atttgtttta 1629181 gtatcccgtc atcaagaagc tcatgcaaag accggtatac ttctgtatga tttggtttaa 1629241 aaccaatctc tttaaattca gaccgaagta cttcaagcag ctttaaccca tagagtctct 1629301 cttgctctgt catcgttatc atataaagct tcaaaaatgc gcgctgtttc actaaaaagc 1629361 ctgttgaact ccttttttct tctttcatca tatgcactcc ttcttctgtc actgacaaca 1629421 ctatgtacta aatattcaat tttcttttat tgttttcctt ctttatatta aagactgata 1629481 gtccagttat ttcatgttta ctgattatag gtgtagcgga aaaaataaat ttcgactgaa 1629541 catttggtac atagttttct tagttctatt atagcctgca tttactgcta tcttcaattt 1629601 aaacgattgc cagggtttac atatctcatt ttaccggtac ggatttcatt caaataaaaa 1629661 aacctgtcga aagacaggtt ttcattttta aggatttgtt gaccataatc ccgctgtttt 1629721 gatgaaaata cgaggatcta atttcagttg tgccaccatg tactcagcaa gatcctcagg 1629781 ctgcataact ttttcaggat taccgtctgt taagttcaat tcgatagaca tatcactagc 1629841 gacagtgctc ggcgttaacg cgctgactct gatattatgt tttctcactt cttgcataag 1629901 agactctgtt aacccgagaa cggcaaattt agaagcgctg taagcacttg ttacagcagc 1629961 tcctctttgg cccgctgtag atgaaatatt aatgatgtct ccggctttgc gttcgatcat 1630021 ttccggaagc accgcgcgag tgacatggta cacacccatt aggttgactt gaataatatt 1630081 ttcccactca tcagctgaca gatctaagaa accgccaaat ttgctgatgc cggcattatt 1630141 aatgaggata tcgatatcac cgagctgttc cttcacttga gctacagctt ggttaacctg 1630201 atcggcatct tttacatctg cagcagcaaa tgcagctttt acaccaagcg ctttgacttc 1630261 ttcagccact ttttctacat tagcggaagt ccggccaatt aacccgatat tcacgccttc 1630321 tttggcaagc gccagagcag tagcgcggcc aattcctctg cctccgcctg tgattagtgc 1630381 agttttatgt tgtaaacttt gcaattgaag caccctttct ttgtttacat atgtacgata 1630441 tcacattata agtacaatac atccaatacg caaatcaaac gaactgtgta aatatcattt 1630501 cttctgatta aaaaaacgga tacagggtaa tgacataaga aaaggagtga acatatgatt 1630561 atagtttata tcagtcttgc agtattagca gtttctatta tcttcttagg agttaccgtg 1630621 atccaaaaca agaaaaaaat agaccccgca ctaaaggagc tttcctctgt tacgcaggct 1630681 atgcaaaaac aaatcgaagg attaaaaaca gaaacagagc tgctgacgca aaaacaaaag 1630741 aagattcagc aggatgtcca aataaaaaaa tacacgcttc agcagaccgc agctgaagtg 1630801 aaagaagttc cccaagcagt caaagaggtg tggcaggcag gacattttaa tagcagataa 1630861 ggatgaatga gatcccgttg ttacgatcag aatggacaaa tgggatctca tttttcgagg 1630921 aggcttacac atgattataa accgcagctg cttaaaagag ttcgcagaaa aagtacattt 1630981 tcttccctct tcacttacaa agtccgattt acttactgat ccatttcgtc tccatcaaga 1631041 aaacgaactt ggcatctact attcacctca taatgaattt atcaatcggg atgcctcgct 1631101 tgtgattgcc gggatcacgc ctggtttttc ccagatgaag acagcgtacg aaacagccgc 1631161 cgaaagcctg ctgcaaggcg ggactcttga gcaaatggca gtagacacaa aaatagcagc 1631221 gggtttctcc ggatcgatga gacataacct tattaccatg ctggatttat gcgggctgcc 1631281 gcaagctttt ggcattcaaa gcgccgcaaa gctttttgga gaattacggc atatgctcca 1631341 tacaacttcc gttattaaat atcctgtctt tatccagcaa aaaaactata ccggatacaa 1631401 accggctatc actcattctc ctatcctaag cacttatgct tttgggcact tccctgcaga 1631461 gcttaaccat gtgacgggac cagctcttct cattccgtta ggaaaagcgg ccgaaacagt 1631521 gtgtgaaaca ttgatcagac agcacagcct ccagaatttg atttgcctta acggctttcc 1631581 ccatccatca ggcgcgaacg gccatcgttt gaaacaattc agcaaaaaca aagagcaact 1631641 agaaagacaa attcgttcct ttgctgcatt ggttgatttc gctatagaaa agaggaaata 1631701 aaagggatat gataaacaaa aacacaaacg tggggagtgg ttgaatgttt cctatattag 1631761 aaacggatcg gcttatactt aggcaaatca cagatcagga tgcggaagcc atttttgctt 1631821 gtttctcaaa cgatgaggtg acacgctatt atgggcttga aaacatggaa tctatagaac 1631881 aggccatttc aatgattcaa acgtttgctg ccctctatca agaaaaacgc ggtatacggt 1631941 ggggaattga aagacgggac actaaagaac tgatcggaac aattggcttt cacgctctgg 1632001 cccaaaagca taggcgcgcg gaaatcggtt atgaaatcat cccggagcat tggcgaaacg 1632061 gatttgcatc agaagtcatt tcaaaggtcg tatcttacgg attttctgcc cttggactgt 1632121 cgcgtattgg cgcagttgta tttaccgata atgaagcatc aaatcgtctg cttctaaaaa 1632181 tggggtttca aaaagaaggc gttttaagac agtacatgta tcaaaatggg actccatatg 1632241 atacaaatgt gtactctatt gtgaaaccaa gagaatgacg gtattctctt ggtctgtgcc 1632301 acatcccttt tcctttaaaa agataaaaag cgcccctcaa acagggcgct ttctaattaa 1632361 gatgcatatt gaggagatgt ttcctcctta actgcttttt cctcaggtat atgaatacat 1632421 tttgtcaaga ccgcacttgc aaggtaaagg gccgcaaaga tccagacgac accttgcgcg 1632481 ccgacgagac cgatgaacag ccaagcgagt gcagggccga caaacgctga taaacctgca 1632541 gctaaattca atacagacat ggctgcccct ttatcttttc ctgccaccgt cggcacaatt 1632601 gcaccaatcg gcacatagcc tgccagcaaa ccgccccaaa taaagccgat cacgctgaca 1632661 accgctaaac ttccgccgga gaaaacaggt gcgtagtata ataagacggt gaaaatgccg 1632721 cagccgactc cgccgaacca aataacagta tttttccagc cgaatttatc gccgacaata 1632781 ccgaagataa ggttaaacac aatgttcccc aggaaaatcg ttccccaaat ttgcagccac 1632841 acattggttg aaattccatg ctgggccatg tgcatcggca aaaagactgg aaaaccatat 1632901 gtaccaatgc tgttgatgat tctgatgatt ccgcctgtaa gcacgcgcgg atttgtaaat 1632961 agaatcgtaa ccccttttaa aagctcctcg gctgtttctg atctttttct tttcttcttt 1633021 tcaaaacggt ctttattgat aaacaatgca aagaatgcac cgagacatac ccagaaaata 1633081 gagctccaaa gcgtattcaa ataaccgaac gctttgatcg cgtagcttga gtaccaagcg 1633141 ccgaacacaa acatgccgag gcaatatgca atccaaaacc agccgacagc agtgctcagt 1633201 ttgctttgcg gtgttctgta aatgacccat gtcaagaaag aataagcaaa aagcgggtaa 1633261 cctaaccctt ttacgaagta agtcacatac atcactggca ggttcagctg ttcaaatcca 1633321 aatacgataa aagcagctgt accgatcaca taaaacaaca gccccataaa catcgttcgt 1633381 tttgcgccaa atgcttcgag acatacaccc gaaaaccagg aagctatggc aagcgcaatt 1633441 ccgtatatac taaaaatgga agcggactgc tgaacggtga gcccgttttc gatcaaaaaa 1633501 ggactgagcc agccttgttc aaggccatct cccatcataa acaaaacaac ccctaaaaat 1633561 ccccaggcaa gccgcttcgg tattcctatt ttatccaaca tatctgtctc ctccttagat 1633621 gctattattc attaccgtat taccttatta aagttgaaaa ttaaatgatt cctcaaaaca 1633681 gcagaaattc cgtcttaaat taatactttg ctttctgatc ctgaaaaaaa gcgctgtgtt 1633741 tgcttccatt cctcatataa agccaattct atctgacagt ccttcggttc gatcacccgg 1633801 acatttgctg acatctcctc cgttaattga aaggtttcat tgcaaatgac tgcagcaccg 1633861 acgacagatg cctgatgata tccctcttgg acatagacct ttttttgaag aagatccgcg 1633921 atatattgag tgagcgcttt gctttggaat ccccctccgc acacccaaac ataatcacgt 1633981 tcaaacggag taacctctgt taaaatgtca aagttccatt tgattgaaaa tgcgatctct 1634041 tctagcgctg cacgtacaaa atgtgccctc tttaaatgtg ctgacagcgg ggcatcaaaa 1634101 agaaaaccgc ctctcgttaa cgcattcttt tcagccgata aataagagcc gagagccgct 1634161 acacatgcat ggtcttcttt tgcaagtgca gaaatctcct cctccattac ttcgtacgtt 1634221 tcattcggat aaaaaatctg ttttaatttt tgataattca agccggtaat tcccggattc 1634281 gtttccacaa gccaatgccc ttgatccgta tgacagttca accaggcttt atgttttgtg 1634341 tcgccatgat cctcagtaat tttggttatt ggcgttgttg tccctgatac aatgacaatg 1634401 tcctcaagtc cagctccggt gcttttgaca gccagctgtg tatccccgcc ccctgctata 1634461 accttagcat ttattgaaag gcctaattcg gatgcatatt catttgctat cgttccaatt 1634521 gctgttcccg ctcttacaag aggcggaagg atagatggag aaaagccgaa aatgtcgcac 1634581 atctcttctg accaagtgtt ttgcttcaca tcaaatagca gggtttctgt tgcctgtgat 1634641 ggttcatatg ttaatattcc gctcagttgg tacgtcaccc aatcactgat gcttgtaaag 1634701 cttgcagtct tttcccataa agagggctgg cgctgtttta atccataaag cttgagcgca 1634761 gaaaaaagtg cagttggcag gcggcctgtg ctgctgtata tctcttccca atcgggaatg 1634821 cccgcctccc actctcggcc gcgattatcg atgttcggca gcccgagaaa aggattgccg 1634881 ttttgatcaa tcaaaacaat cccctgtctt tggctcgtcg atgtcaaacc aatgatgtca 1634941 atatcacacg aacgggatag cgcacgtttt gccaaattca tcacctgctt ccacagcacc 1635001 tgaggagaaa aataacggct gtccgggtaa agcgtctctg tggaatactc gatgtcctcc 1635061 cgttcaactg ttagaacact gccagttaca ctcacgaccg ctaccctcgc attgcctgtg 1635121 ccaatatcaa aaacgagata gcctttttgt tttttcattc tgttagcctc ctttcttatc 1635181 cccctgtttt cagtgcgtcc ttgttataca ttgtctgaat attaagagtt ttttcaccct 1635241 tccacttttt gagggcttta ttcagtatcg tcacgtgatg atcctccact tcaaatgttg 1635301 ctccagcgag atgcggtgtt gccagaacat taggcaatga aatcaattca taatctgatt 1635361 cctctggagg ttcatgataa aaaacgtcta gtatcgcacc gctgatttta tgttctttta 1635421 atacaaataa aagatcttca cggtttacaa caactgctct tgaagtatta acgaaaatcg 1635481 cactctcttt catcagatca aaatattgcc gatctatcag tccgagtgtt tcctcagtgc 1635541 gaggcagatg gacagaaacg atatcgctgt ctgaaaacac cgttttaaga gatgcttttt 1635601 catacaacgg atgatcgtct tgaatgtatg gatcgtaata ttttatctta cagtcaaacg 1635661 cagtcagcag ttttgcaatc ctttgcccga ctgcgccgaa cccaatcatg ccaaccgttt 1635721 ttcctgttag ctcatttcct ttaaatttga cataagcctg caggtaatca ctgtcccact 1635781 ctccatcctt cagccactga ttcgaggcgc tggtatggcg cagaaaggaa atcacatttc 1635841 caataaacat ttcggcaacg gcttgtgcat tccgccctgg tgtataaaaa acaggtatgc 1635901 ccctttttga ggcagctgcc acatccacat ttgagggcat tcccctgcaa acaccgacaa 1635961 atgaaagttc gggaacagaa gcaaatacgc tgtctgttac ctgatcaagt tcagtaatca 1636021 agcctgtcgc atttgttgct tttagcagct gaatgagttc atcctcccga tatgccctac 1636081 cttgttcctt ccaagattga taagcaactg agccaaacaa gttttcaagc tcttttcgtc 1636141 cttcttcgtt gtacggtgct gtaaccaaaa ccgtcatgct gcaaaacatc cttttcatcg 1636201 tatttttcat aaaaaaaatc tctttccgaa gatggaaaga gattcatata taggcgcgct 1636261 ctgttacagg cagacgccgg tataaacctt gctttcctat ctttcaagct agcgcttgct 1636321 ggaattggca caataatgtt gccgaggttt catagggcca gtccctccac ctctctggat 1636381 agaaaatatt gagtatgtaa ttttcagaat gaagaatacg tttatcataa agaagactca 1636441 gattgatgtc aatctctttt tttcagaatt gacgttatca tcggaaatgt tataattctt 1636501 acaaaatatc taactagaga gaggaactgg gccatgagat cttttgccac acaacaaaac 1636561 ggcattttca aatccgtttg ctcgctggac tgcccggatc agtgcggatt gttaatacat 1636621 aaaaaagacg ggaaaatcgt aaaagtgcaa ggagaccctg atcatcctgt cacagctgga 1636681 aacatatgca acaaagtccg gaatatgacg gagcgcatct atgatgaaaa gcggctgact 1636741 acaccgctca aacgaacagg tgcgaaaggc caagcgatat ttgaaccgat ttcctggaaa 1636801 gaggcaatcg atacgatcac ctcccgctgg aaacagctga ttgatgaaga gggagctgaa 1636861 agcatacttc cttacagctt ttacggaaat atggggaaat tgacagctga aggaatggac 1636921 cgccgctttt tttaccgcat ggggtcaagc cagcttgaac ggacgatttg cagcaaagcg 1636981 ggatctgaag gctataaata tacaatgggc ataagcgcgg gaatcgatcc tgaggaaacc 1637041 gttcatacaa aactatttat tttttgggga atcaacgcgg tcagcacaaa tatgcaccaa 1637101 attacgatcg cccaaaaagc gcgaaaaaaa ggtgccaaaa ttgtcgtgat cgatgtgcat 1637161 aaaaatcaaa caggacgtct tgcagattgg tttatcccaa taaaaccggg aaccgacagt 1637221 gcacttgctc ttggcatcat gcacatttta tttaaagaaa accttcatga tgaagcattt 1637281 ctgtccgagt acacggttgg ctatgaagag ctccgtgaac acgtgaaaca atatgatcct 1637341 gaaaaggtat cgacgatcac cggtgtcagt accgaagata tttaccgact ggcaaaaatg 1637401 tacggggaaa cctccccttc ttttatcaga atcggaaacg gaccccagca tcacgataac 1637461 ggggggatga ttgtaaggac gattgcctgt cttccggcga tcaccggcca atggctgcac 1637521 acagggggcg gcgcaattaa gcataacagc ggaattttag aatataacac aaatgccttg 1637581 cagcggcccg acttattgaa agggcgcacc ccgaggtcgt ttaatatgaa tcagcttggc 1637641 agggtgcttt tggaaacaga cccgccgatt cgctctctat ttatttacgg aacgaaccct 1637701 gccgtcgtcg cgcccgaagc aaacaaagtc agacagggct tgctgcggga agacttgttt 1637761 actgtggttc atgatttgtt tttaacggaa acggctgcat atgcggacat tgtactgcct 1637821 gcaacatccg cttttgaaaa tactgatttt tacacctcct actggcacca ttacattcag 1637881 cttcagcagc cggtgattga gagatatggg gaaagcaagt ctaacactga ggttttccga 1637941 ttactggctg aagccatggg attcacagac caggagctta aagattcaga tgaagtatta 1638001 atccgccagg cgcttgacca tccagataat ccgcatttgg cagagattga ttacgattca 1638061 cttactaagc attcatttat gaaagcgaaa cgtgaaaagc cgctgtttcc gggcgaactt 1638121 ccaacgccaa gcggaaaaat agaattatat tcagaaaaaa tgaaacaaga cggcttccct 1638181 gctttaccga catatacacc tcttgtaacc gataatgaac atccgtttat gtatgttccg 1638241 gggccaaacc ataatttctt aaactcaaca ttttccaata atgaaaaaca catcaagctt 1638301 gaaaagacgc caaagctctt tatcaacaca aaagatgctg aaaaacacgg aatcgttgat 1638361 ggggcacctg tacgaatttg gaacagccgg ggagaatgcg agctgaccgc tgcagttgga 1638421 gaacaagtgc tgccaggtgt cgttgtcagc caaggattat gggcggatga acaaggaaaa 1638481 aaacagcttg taaacgcgct aaccccagat cgcttgtccg atatgggcgg cggcgccacc 1638541 tttttttcag gccgtgtaca gattgaaaag gtttgaaaaa taatgaaacc cggagtatgc 1638601 caagcccgta taacataaca tcgacataat ggaggcatac acatggacgt ttttttagga 1638661 attggtattg ctttggctgg atattttatc ggtgaaggct taaagcagag gaaccaaacc 1638721 aaaggtaatg aacaaaatga tatcttccta ataaaagaac gggatattta cttttacatt 1638781 ggactttttt taggaataac aacgactgaa gcaaaacagt tagctggaga catggcagac 1638841 ctgccttaca tcgaaataaa cggaaaaaaa tatgtccaga aacatatgtt aaaagattgg 1638901 acattcacat tagttgaaaa acatcagggt gaataaaaca aatctgagga gagcgagatt 1638961 cattgtcacg ctctcctctg tttagctgta tggatcctgc caccaaaact ttgtgctata 1639021 agcgctgata aaacgataaa ccaccatcta tgttctttcc tcaaacaact caagatgccc 1639081 gttccacaac aatagttttt atattccttt gatgacgtga tgttcttgat gaacgtatgt 1639141 atcgtaaaac acttagaaaa cctattcggt ttgaatgtgt gctctcatta tgcccccata 1639201 ctgcgccttt atccgcggag gattttttta aaaaaatatg aaacctaaag cttttagatc 1639261 ctgaattttt attgaacctc catatttctc cgattggtaa aaattagcct atacaccgga 1639321 agctgtacgt ttataaagga tcagagaatc ccataaccag taaatcactg cagccgcaat 1639381 acttaacata taataaaagt acgattgcaa tgtccatgct attgacgcag gttcattgat 1639441 aacaaaaaac aggaaagctg cgataaaagc aaccacactg taaatcaata ggtacatgac 1639501 attgaaagtt ctcgcttttt tctgcaactt catttggagc ggaacagcaa aaaggccata 1639561 caccacaaaa ccgtataata aagcaattgc tgccgtaaac aatgcaatta tcatatcgcc 1639621 atacataacg aaagaataaa accctaataa caaaccaaat gtaaggctgg atagccctaa 1639681 tgtcattaaa taatatgatg cgattttttt cattttttca ccccccttgt ttgatttatt 1639741 cacagtgctg ttagtataaa ttcacaacct ttgtatttct tttatcgaga tgtcttccct 1639801 aacgtgctat acgcaatgcg ctaataaaag gtttcaaaaa tgacgttctt ttattagata 1639861 atacgctggc tgaaaacgcc tctcctgatt ggccaaagcg cgaatgaaaa aagtgcatga 1639921 atacctgccc aacagacaga ataagaagag ttgatatttc aacacttttc gtaaaggggt 1639981 gaaaccaatg agtaagaaag gtattcaaaa ttcaagtatt gaacaaataa gaaatgacca 1640041 tgagactgaa acagctttta aagcagatga tcctaaaaaa cacggttccg atcctaaaag 1640101 aacgaaataa gttcttaccc ccactaaaat atcaataatc tggaggaagt aaagtgactc 1640161 aaaaaaacgg tgcagacaga cctgatgatt ataaaagatt ttcttcatta gacaaggaat 1640221 atgattttca gcaatctata cgcagcaata ctgagacaga aagtgtaaac actgaaacac 1640281 aaactcataa caaagaaaac aaaaatgaca caacagatgt tgccgggaaa tactttgagc 1640341 cctcagatta taaaggaagc acgcaattag aaaaaggatt ggctgaaact catgaacagg 1640401 tcagcgatga ctattttgaa gggacaatcg atcaaaattt ggactagcca tacaaacgga 1640461 actaacttaa aagaagtcag ttaactctgt ttttagaaac aaccacagta aaagtagcca 1640521 acccccaccg aataagatgg gggttgcacg taagtagcct gtttaatatt taaaacgatt 1640581 aatgacggtt tgaagttctt ctgccaactg agatagagat tctgcggcat aggagatttc 1640641 ccccattgaa tgaagctgtt cctgtgatga atttgcaacc gcttctgtat ttgctgacgt 1640701 ttcttttgta ccagcagcca atgtatgaac tgtgtgctga atcacttcaa cgcctgaagt 1640761 aagctgttga gttgctgctg caacttcttg tatttgagaa gtgacctgtt ccaccaggtt 1640821 cagtatttca ttgaaatttc ctgttgtctc ttgagaaaga acaatacctg agctcacatt 1640881 ttcttgaaca actttaatat tatttaccgt ttctatcgat tcgttttgga tggtcgctac 1640941 caccgattgg atgtggtttg cagatttatt tgtttcatcc gccaacttcc gaacttcttc 1641001 tgccaccaca gcaaatcctt ttccttgctc tccggctctg gccgcctcga tcgctgcatt 1641061 tagtgccaac aaatttgtct gctctgaaat cgtcgtgata agcgaagaga tatcgctgat 1641121 ttctgctgtg ctcgctacca atgtttgcaa tccattgccg gctgaatcta cagatttatc 1641181 aatgaatttc atctggtcta acatcttgtt gacggactta gagcctattt cagccttgtc 1641241 tctcatcgaa gaagaaagat ccgctatgtt ccctgtattt gaagcgactg atgatatact 1641301 gtctaataat tcagtgatgg attctgcgct cttttctgtc attgagcttt gcttcacatt 1641361 gctgtcggca gccatctgca tggctcgtga aatatgttca gatgttgatt tcgattcttc 1641421 cgcgcttgcc gataattctt cagaggaagc ggcgacttgt tcagatgagc tgctgatctg 1641481 cttcacaatt tgagttaatg aatgagtaaa agaattaaaa gattgggcaa gctggccaaa 1641541 ttcatcttta tttttcacaa tgactttttt ggttaaatca gcctcgccgt gtgcaatttc 1641601 ctccagctgc ttatttatgc ttcttagtgg caccataatg gactttaaca gcattatgct 1641661 tagaacaatg cctaatatta ctgatatccc tgtgacaatg ataatgagcg attgactcat 1641721 tttcccattg ccctgtattt catcctttag atcctctacc tcttgatcca ggcgatcaga 1641781 cagcttattg acagccggag ctacgccttc ttttcttatt gttctttctt ctccaaaatg 1641841 gatggtttct gcttttttag gatttgaaga gtaggctgtt actacttgct gattcaaagc 1641901 tctatactga gtaaaacttg tcttaatgtc ttcaatattg gattgatact tctcttcatc 1641961 aatcaagtca ttaacccggt caaggctctt taagacatcg tctgcttttc ccttcatacc 1642021 ctcgtcgtat tctttgtctc tggtaatcaa gaagcctctt tcatcatttg ataacccggt 1642081 caattcatat tggatgtgtt ttatctcttt ttggaattcc attttgtctt taagttcttc 1642141 attctttttc acagtagaag aaatcataaa tactgaggag cctccaattc caataattga 1642201 aacaactaat attgatataa tccccagcaa ttttgttttc actttcatgt gtcgttttcc 1642261 ctttccgcac aatgtaatgg ctgaaataaa atatgttcaa gcgcgtttga atccaattcg 1642321 cttacgctca tgtccataat atcgacacgt gttatcaagt tttatagtga tattcttata 1642381 tgaataagca aattctttac gtctctgaac ttacagaaaa accttaagta aaatttgcag 1642441 tcttttgcgg tatgtaagtc actcttattc gtttttctaa aaaaggcttt tcccacctca 1642501 aattggctga accggctgtt ttctcgaaaa tataatacaa tacgcagcat aatatgaagg 1642561 agcgaaactt aaatggggat catcaatggt aaagaattca ttgaccgatt gaataaacta 1642621 gaaaacgaaa tatggtatga tggcgaaaaa ataaagggta acatttctga gcatcctgca 1642681 tttaaaggaa taatcaaaac aaaaagctca ctttatgaat tgcaaacaaa ggatgagtta 1642741 atacatgaaa tgacttattg ccttcctgga gatcataatc gaatcggcct ttcctatctc 1642801 cagcctaaaa caaaaaatga tttgaaaaaa agaaggacca tgattgaaca ttgggctaga 1642861 catactcatg gaatgatggg gagaagtccg gattacatga atacggttat gatgagcttt 1642921 gcttcgtcag cggagcttct aaaagataaa gagaattgct ttcctgaaca tatactagat 1642981 atgtatgaac aagctgctaa gcatgacctt tcctttaccc atacattcat tactccgcaa 1643041 gtgaaccggt cacagtccta ttttgggcta agtgaaaaac cgatatctgc taaagtcatt 1643101 gatagaaccg aaaaaggttt aatgattcat ggcgcacgac tgcttgccac acaaggcggg 1643161 ttgaccgatg aaatcttggt tttttcagcg cctaaatttt tctttgaaac agatgaagct 1643221 tatgcttttt caatcccttc taatacaaaa ggcgtaaaat tcatcacaag agaatcattt 1643281 gtattaagcg actcttcctt taatcatccc ttaagctcaa ggtatgaaga aatggattca 1643341 attgtggttt ttgatcatgt gttagtgccg tggaatcgtg tgttttttta cgataatgtg 1643401 gaagcagcta aagattttat gacaaaaagc tcttttcatg cctttacctt tcaccaggtt 1643461 gtcattaggc aaatgataaa aattgaattt ctattaggtg ttgcacagct tcttgtcgac 1643521 accattaatg tttccgaata tcagcacatc caagaaaagc tctcagaaat cattgtggga 1643581 ttggaaacaa tcaaagccct cattgacaaa tcggaaaatg atgctcagtt agatgaattc 1643641 ggctatatgc gcccctgttt aattcctctt caagtcatca gtacgatcat tcctaagcta 1643701 tatcctcgat ttactgaaat catacaatta attggagcta gcggaatggt gacactgcct 1643761 accgaaaatg catttgactc agagatacgg gaagatcttg accaatatct tcaagcaacc 1643821 aatacaaatg ctgaagaacg tgtgaaaatt ttccgtttgg catgggattt aacaatgagt 1643881 tcattcggaa ctagacaaac tcactacgaa agatattttt tcggagatcc tattcggatt 1643941 tcaagcaggc tgtataccag ttatccaaag caggagcagt tgaacatgat taaaacattt 1644001 ttacatgcag atacagaaca ttgaaaaaac agcgggaaaa gatccgctgt ttcgtatttt 1644061 ttattcagga aactgaacat ggcccggtac tgtataggct ttggacgttc cgctttcagg 1644121 cagctttgga atggtgtctt tcacaacttt tccgcggatg tcagtcattc tgactttgag 1644181 agagccagta cctaaattcg tactcacaaa atggttatag tccattttct ccatgttgat 1644241 ccacttacca tccttttcat attccatttt cataacagga tacttgtgat ttctgacttg 1644301 gattgctgcc caccacctgc tgctgccttc tttgatccgg tacgtgaaat tgccggtgat 1644361 tggggctttg acaacacgcc atttaatatt gatttttccg tctttcatat tgccgatttt 1644421 acggaaggca ttaggtgaca gatcaagagc tccccgagcg ccttcgggat aaagatcagt 1644481 aacatatacg gttgttttcc cttttggccc ttcaacttcc aaataagagc cggcaagtgc 1644541 cgcttttact cctccgtaat tgagatccgc cggatttatt gcagtaatct ccatatcgga 1644601 aggaatggga tccagcagga aagctcctcc tgaatagcct gaccctgtat acgttgcata 1644661 accttcatgc aggtcgtcat atgctgccga agcttgcggg gaaaaacaga agatcgtcaa 1644721 caaaaccata ccaacaaatg cactcatgat ctttttcata tttggtcctc ctcaaaccag 1644781 acttcaaatg agaatcatta tcattataag actcaatcca tctggtttga aagaggaaat 1644841 agattcatag ttgattttaa ggcaaattca ctatcattca tatatcaaat gtaggtactt 1644901 atgaaaaagc caatacaaat gaacgaatgt gcacttcagc cgaatgtctt atttttccct 1644961 ctcaaaattc gcatttcaat aacgaaatga aacaggctgt tggcctgata acagctatac 1645021 aggaaaagct atttttcccc gctcagtttc aacttagctg tcatcatgat gccaaagatc 1645081 agcacaatcg gaacccaaat aatgaagtga taaaaatcag gctcagccag agcaacaata 1645141 atagccccta cacaatacaa aataatagcc agtgctctta acacagtatc tcttaagaaa 1645201 gtcttctttt gcttcttaaa aaacaaacgg ccggatatat cctctaaaag agaagccaaa 1645261 gtgccggtca acacagttga agaaatacct gcaatcccca gtttttttgc tgctgtagtt 1645321 tgaatcccca tagaaatgct catgagtata attagaatgt gcacaggaac aaatgcccgg 1645381 taaaaagaaa gacaagcaaa gacaaacaaa atgaatgctt caagtgcgag ggcttttgtc 1645441 acagcagaag gccaaagggt attttccgcc tttccgacca tcaatgtagc aatgatcacg 1645501 ccgcatataa atccgattag cgcagtcaag gaattaaaaa cagtgacctg aatggatttg 1645561 ccgatagcta accccaataa tacaatgttt ccagtcatat tagctgtgaa cacatgtccc 1645621 aggcttaaat acccgattac atccacgatt ccagctgtta aacataaaag tgatagcaag 1645681 gtgtttcgat aagctgctgc agtcaacggt gtatcaatcc tttcttctat ttcaattgtt 1645741 agtatgtctt ttggcgcaat ctctattttt taagtaaccc aacattaatt aggaagatag 1645801 aacctattat tcctttccat taactgtaat aataatcccc gcaaggaaat gattaaaatt 1645861 gaaaggaagc atattgtgat gaaacgactt tgtttatggt tcaccgtctt tagcttgttt 1645921 ttggttctct tgcctggaaa agcattaggt gcagtcgatt ttccgaatac ctcaacaaat 1645981 ggccttttag gttttgccgg aaatgccaaa aatgaaaaag gcatctctaa aacgggcaca 1646041 acgggtggaa aaaacgggca gattgtttac attcaaagcg taaatgattt aaaaacccat 1646101 ctaggaggat ccactccgaa aattttagtg cttcaaaatg atctttccgc atctgcgaaa 1646161 acaacagtta ccattggctc aaataaaaca ctcgtgggct cttacgcgaa aaaaacgctg 1646221 aaaaatattt atttaacaac ttcatcagct tttggaaatg tcatttttca aaatttaacg 1646281 tttgaacaca gtccgcagat taacggaaat aatgatatcc agctttattt agattccggt 1646341 atgaactatt ggattgatca cgtcacattc tcaggtcata gctataatgc aagcggaagc 1646401 gatttggaca aactcgtgta tatcggaaaa tccgcagatt atatcacgat cagcaactca 1646461 aaatttgcga atcataaata cggtttgatt ttaggatacc cggatgattc tcagcatcaa 1646521 tatgacggct acccccacat gacaatcgcc aataattatt ttgagaactt gtatgttaga 1646581 ggcccaggtc tgatgagata cggttacttt catgttaaaa acaattacag caataatttt 1646641 aaccaggcga ttacaattgc tacaaaagca aaaatatatt ccgaatataa ttactttggg 1646701 aaaggcagtg aaaaaggcgg catccttgac gacaagggca ctggttattt caaagacata 1646761 ggcagctatc catcactcaa caagcaaacc tctccgctga cttcttggaa tcctgggtca 1646821 aactatagct atcgtgtcca aacgccggaa tatacaaaag aatttgtcac gaaatatgcc 1646881 ggatcacaaa gtacaactct ggtatttggc tactgatata aaagaggccc tgcgttaaaa 1646941 acgctgtgcc tctttttata ctataggcta tttttaagcg atccttgtaa ttccatcaag 1647001 atccagcgtc ggtcaaacta aaaagcatat gttcttttcc acaataactt cttaactggc 1647061 tttcttatta taccagttta tcgcaagtga aaagaaatca ttgttctgaa cctgtattaa 1647121 atgaacgatc gtcccacaaa ctacttaaaa acccctaaaa aggatgatgg atatgtgcgg 1647181 caggtttact ttgtactctg catttgatga tattattgac cagtttgaca tcgatcaatt 1647241 ttttcctaaa ggtgaatacc agccaagcta taatgtcgca ccatcacaaa acatccttgc 1647301 aatcatcaat gatggatcaa ataatcgctt aggcaagctt agatggggac ttattccacc 1647361 ttgggcaaaa gatgaaaaga tcggttataa aatgatcaat gctcgagccg aaacaattac 1647421 cgagaaaccg gcctttcgaa gaccgcttgt cagcaaacgc tgcatcatac cagcagacag 1647481 tttttatgaa tggaaacggc ttgattccaa aaccaaaatc ccaatgcgga tcaaattgaa 1647541 atcatctgct ctttttgcgt ttgctggctt atatgaaaag tggagcacac atcaaggata 1647601 ccctctttat acctgcacca tcataacaac tgagcctaat gagttcatga aagatataca 1647661 cgaccgaatg ccggttatat tggcccatga tcatgaaaag gagtggctta accccaaaaa 1647721 tacaagccct gattatctgc aaagtttgct gctgccttat gatgctgatg acatggaagc 1647781 ataccaggtt tcatcattag taaattcacc caaaaataat tcagctgagc ttcttgatgc 1647841 agaaaatcat atgtagtgat tgaaaaaatt ctctagcaag aacttgtcaa atagctttgt 1647901 tccttaggtg ccaatccctc tagtaattat gaatatttag tacatagatc aattagttat 1647961 ctttagcatc agtttgaaat aattttatta tgtaaactta aataagcaat gttattcctt 1648021 tcatataaaa tagtttacat ttttataaaa tcgcttcact tttctatttt gtcagcaaaa 1648081 aaactgaacc acattaaact tatgaaacct gccgcacctg tggattgcaa atatgatata 1648141 agcccataga ggtaaatcca tacactttcc ctcctaagaa ttaaatgaaa tttctttcat 1648201 cttacatgaa ggtcttcttt cttttgttta tccagtgtaa tacttaataa tatgttgatg 1648261 aatgcagctg gaaaatatat aaatcccact ccaagaatgc ctagtatcgt acttaaactt 1648321 actatgtaat tctttgtcat cgtttgactg tcaatcaata ttagaagtga aatcaatcca 1648381 gctaaaacac ctataaacca agcatcgcca acagcataag aatcatccag catccctaac 1648441 catcgcccca atatagagct cccaatggca gtcaaactgg ataaaaatat gagtgctttc 1648501 atttcttctc ctcctttaaa gccaatcaaa ctggtagaaa tcggccattg aatccccatt 1648561 atcgaatggt taccatttca tttccacatt aacattttaa agctcattac aatacgattc 1648621 aagcagaaaa accctacata acgtatatat agggatttaa taaaacacag gccaaaattc 1648681 agctctatct actttaaaaa gatatgaagg gcagctgtgt gatctgttac gtctttacgt 1648741 accgggatat ttcacaacag gcactttctt cttgcgcaga gaatcaagca tgactgatcc 1648801 agcattcaag ttgctttgta ctaattcttt aggcgtcaat gccatccact gattgagtga 1648861 cacatctgca tagcggttac ttttgaacat ttctaaaaac cataatgttt ctgtaccagt 1648921 gttttgtata tagtgtccgg cattagaagg cacgtatcca acgtcgcctg ctctataatc 1648981 aaatgtgcgg gcagtcccat ttccgataaa taccgtcatt cgtccctgtc ctgttagata 1649041 atattgccac tcatcgctat tgggatgcca atgaagctct ctcatcgcgc caggctcaat 1649101 ctgaacaagt gcagcggcta tcgtttttga aattgggaag ttagaagaat ccacaattcg 1649161 tacactcccc cctggcattt gaattggggg ttgatttaac agctcgtgtt taaaggtcat 1649221 ggggactttt ccatatggtg actgaatgtc ttcactggcg actgatcccg gcacattccc 1649281 ttggtagata tagacttgct cagacggaag agagttgaaa gcattctccg ggacaccgaa 1649341 atttgcagac agaacatctt ttggtgtgtg tgcaagccaa tctgaaatgg ttaacgttga 1649401 aaactcagaa aagttcccat catcgaaaac gagcagaaac tcgcagtgtt ccaatccctg 1649461 tatggaatgc ggaattcctg ccgggaagta ccaaaggtcg ccgggaccaa catcagcaat 1649521 gaaatttcgt ccgtcttggt caacagcggt gatacgtgcc cgtcccaaaa gcatataagc 1649581 ccactccgct tgcttatgcc aatgaagctc gcggacgcct cccgcagtta agctcatgtt 1649641 tacacctgca atcgcagtcg aaatcggaag ctgtcttacg gtgatttctc ttgaccagcc 1649701 gccgtgatct aatttcatgg gagcgtctga gaatgaaaat ctcaagttag gaatcatacc 1649761 ctcatctgta acaggcggaa caaatatatt cggattttga atatcccgta ttatatttcg 1649821 cgggcctgta tcaatagctc cagctccatc acttcgaata ggctgcggca cgtttctgtc 1649881 ttcatgattg attggttgtt gttccaacag catgcacctc gttttagaaa tgaacaagat 1649941 tttatttcag cctatgcaga atcttagatt gctgtgccta ggaatccgca aataaaaaag 1650001 tgaccaccaa tgtgatcaca aatacatcaa ataaactatt ttttatacca tggcttctta 1650061 tgtaatttga ttgcttctgt ctgttttttc tggcctgtcc tccactccac ttttactaat 1650121 acatcatgac ctatcacttc atcttcaggc atataatcaa aggtggaaat atggtcctcc 1650181 atgcgtcccc cacccggcat ttcatcacct gtgtactccg ataagtcgta ctcatctacg 1650241 ttatcatctt gatacttttc gccatctaca tacagagtaa ttctttcaac aacagtccac 1650301 ttttcttcct tcttactccc ctgccaatat agatttagaa aataattggg tccaattgaa 1650361 gttttgtctg atttttcaag gttagacatc cacagtccgc ttttcccgct gccctcatat 1650421 ttcactttgt tccctgacac cattacaaat aatgtgatga tgcagatgat caagaatcca 1650481 gcaatgatca atagccattt cttaatattg ttcttttttc tcatgttttt cctcactttc 1650541 ctaacttttt agtaggaaaa tacgatcaaa atgttaccga aaagaaaata agaaagggct 1650601 aatgatctaa cagatgactg tctaaacttt tgacttaaat taaagtgctt tctaaagaca 1650661 agattaaaac gtataacagc tcttaaatgc attttttgtt tcattgagtc aagaacctta 1650721 aaatggcttt ttattattaa aaatcaagct agtgtattaa gtaacttttc aaatttattt 1650781 atactcatga tctcgtgagt cacaaatctc ccatcaaaaa aaacgctaaa agttgtccaa 1650841 atagctggtg acttttgtgc ctcttctttc gatgataact gaattgactg aaattgaacc 1650901 cctttctttt cagtcaattc ccgcaaatca tttatcatgc ccactgcaaa cggacactga 1650961 gctgtatagt atatcgtaat ccccttttca ttgatagaat cacttttcac ctggctctta 1651021 aatgcaggag aatctgcaag gccattccaa gtcaaagcca ttaattgaaa ataaggggca 1651081 gcttcatctt gtagagtaaa ccccatatgc tcaaagaaat gcttatcact taaatagggc 1651141 agttttttct tgcctgcgat atggataatg ccatccatgc cgcacgcttt cgcatctgct 1651201 atacatttgt ccaacaatcg tttcgcatga ccgttatttt tatatctgcc agacacccac 1651261 agacaattaa tgtacataaa attaggcgca ttgataggca cccatgcctc attcgcaggt 1651321 aggtattcaa taaagacttt tgcccgttca tgtaagcgat agaacaccaa tccttcatcc 1651381 attcgagctt tgagccatct cttcttttca ttaactgcat gctcatattg tttcgtgctt 1651441 aatgcacagc aaatatgatt gtcttcaata ttgtcctttg tgatttcaat gtagcacatc 1651501 tcctctttcc cccctttaac ataattacat ggaattcaac ttcacacttt acatgcctaa 1651561 tagaataaat acccgttcca acttaaatac tttttctttt ccattttgcc aattaactgt 1651621 aaaacccttc ttttattcag atattatctt gattcctata tcacccattt caaatccaaa 1651681 gtgtgttcat ctttgaggat tagatgcact gcttatgcta taaatacagt acacgaagtt 1651741 ttttatttga agtaatattt gttacgggac agcaatagta aataagtgat aaaaggggaa 1651801 ttaaacttgg tggaaaaatg ttattcttgt ttaatttgcg gatacaaagg attaattcaa 1651861 aatcctttgt ataaaggcga gtatcaaaaa acgtttgaca tttgtccatg ttgcggtttt 1651921 gaatttggct acagtgagga tcatgatgtg aggttaggtt ttattgtaac tcctgatcat 1651981 ttaattgagg ctgcatttca attgtatcgc aaacaatggc ttgagagcgg gatggtaatt 1652041 gctcatccgg aagatattcc agaagaattg aaaaatggca attgcttaaa atttgaagtt 1652101 ttgttgaaac aattgaaaaa actaaatctt gacatagaaa attttgaaat tagcggtttt 1652161 taatgatgaa acaggttgca cttgtttagg tttcactgtc attatcagta aaatgttaag 1652221 ttgaaatgcg caatcagtca caaagtctct attcgtattc aataaagact ttgtgatcat 1652281 cgacaaacat ttcactccca tcggataaag tatccaaaag gcctcctctg gttcttctct 1652341 atagtcatta atcacagtca ctttgacatt tgactcagct atgattggtt ttccaacaat 1652401 ttttcgtttt ttcctcaggc aaagtaagag atcgaatcat caaagccatt ccatctttac 1652461 tgtctaatta acgccatctt cagtgaattt aaaggtctgt tttaaattgc gtccttcttg 1652521 ccccttctgt gtccaaatta taacaacctc taattcagag gccttatctg ccagcataaa 1652581 atgattgaac ttcagcggtg agccatcatt taaactttca gctaacattt tagaatcttc 1652641 ttttggtttg acacaatttt catcgggaca tccaaaaagc gaaaaccttg tgattgaatt 1652701 agggtcattt ctatacaatt gcacatccac tgtagctgct ttttccccta tatttttgac 1652761 ttccaaggaa tatacttgat attctccttt atgaggtctc gtaaattcct ttacattttt 1652821 tgcttcactt acttttactg accactggtc tgttttttgt gtaataggca acaccgtaaa 1652881 agtcagggca tgcgcttttg attggcaaaa cgtaaatcca actgctgtaa aaacaattac 1652941 agaaaataat acccttttca cttcatttat ccctccttcc tttcactggc cgctccttaa 1653001 agaattgatt ttgagcaatc tacaagctct cttaaccaaa accttacctg aggttttgtc 1653061 tttactgctc tgcatttatt tctttcggta tccgagaagg agctttgggg atttttctca 1653121 atctgctgtt aatcacatca gaagagtata gcgtaataat catacttccc ccataccttt 1653181 ttgcccgaat taagattggt tggttatatt ggttttgaaa gcgaaagtca ggacctcccc 1653241 agcttaccgt cgcatcccgt ccgggcggta catatggtac acttctagta tgagaatagc 1653301 gctgaacgat ctgcagtcct gcacgatcta ctgcattaaa tagagttgag gacacctgac 1653361 aaattcctcc tcctacacct tcagacaact ccccttttac aataatgggt gcacttttat 1653421 atcctttgtt ccgagttctc attcccacaa cttggttaaa cgaaaacgtc tcattaggga 1653481 aaacaacgtg attgtcgatt gcttttgcag aaagagaaat attgtgtgaa cggcttttat 1653541 tgcttgagtt aaaatacgtc acgtactgac caagctgctg cgtactgatg tgagctagca 1653601 gctcgctgtc aactttcgga taaatgttca tttccggcac ttctatcttg gagggacctt 1653661 gcccataaaa atacgcataa aacttttcca taaacgcctg ttgatacagt ttgtagccaa 1653721 ccctgcccgg gacgatgctt ccatgatcgt taaggacagc atttatcggc tcacggtaca 1653781 ctttctgatc aagctgtttg atgaatttac tgtatttttc atagtcaacc attggagtgc 1653841 cgggaagagg cattgtaaag tcttcacggt taacagtggc aatcgtccgt ccttgctgtg 1653901 tgaccgttaa actgtcctgc ggctcactcg gctgagccaa taaaaaaaga ccagtgatca 1653961 aaatttgtat cataagtcgg tttacctccc aatcattagt atgaacagcc gcttatcctt 1654021 tgatgtattt cttcccatcg tttgtttgaa tctttagacg ttgataaaaa ccttcataaa 1654081 agagcttagc tttatgttca caccgatccc tgagctcact gaggcacacg gttcattcag 1654141 tcggcaagtt tgaagtagtt cagcatctcc cagtgatgag ggatgctttt ttgtcttgtc 1654201 aaaaatgaaa agggtctcct ataacaacaa aaaatcaatc catttcaata tttttttatt 1654261 gagaaacgat aaattttttg ttacattcaa ttagacaaca aataaatgag gtgcttgtta 1654321 tgaatcgaat gtcgacaatt tttttaaaga tagctttggt tcttattgga attccaattc 1654381 ttgctttatg cattttttta gtgcctaagg tagccaacta ttcagcagaa ttatttccaa 1654441 atatcgctta tataaaatat ctcgttttca tctatttgta tgtaacggcg ataccttttt 1654501 actttgctct ttatcaagcg ttcaaacttt taagctatat tgacaaaaac aaagctttct 1654561 cgggtttgtc tgtaagagct ttgaagaata taaaatattg cgcagtcact atcagtatct 1654621 tttacgcagc aggcatgcct gtcttttatc tgatggccga gatagacgac gccccgggta 1654681 tcattgtgat cggattggtt attatttttg cttcaatggt gattgcggtc tttgctgctg 1654741 ttcttcaaaa actgttaaaa gaagcgattg atataaaatc agaaaatgac ttaacggtct 1654801 gaggtgatga catggcgatt attatcaaca ttgatgtgat gcttgctaag aggaaaatga 1654861 gcgtaacaga gctttcagag agagttggca tcaccatggc taatctttcg atattaaaaa 1654921 acggaaaagc aaaggctatt cgattatcaa ctttagaagc gatttgcaag gctttagaat 1654981 gtcagcccgg ggatatattg gaataccgaa gtgatgaaga cacaggattc gtaaagaaaa 1655041 aatatgaagg atcaacagaa aaataaagtg attggcggtg agcttatgga cataaactta 1655101 tatccatcta gctgctatac taagcgtccc tttcatacac gaagaacaca actatggagg 1655161 aggcatacat catgagagcc ataaaacaaa tcgtccattt tggctgggaa caagcccttt 1655221 catgtttgtt tcctgccgtt atttttgcct ctttggctat tacgcaaatc atcccactgc 1655281 ccttcttgcc gcggtatgac tggctgctca ttatctgcgt tctcatgcaa ttgtggatgg 1655341 tgcgttccgg tcttgagaca cgggatgaat taaaagtgat cacattattc caccttattg 1655401 ggcttgctct ggaacttttt aaagtccata tgggctcctg gtcttatcca gaagaaggat 1655461 actccaaaat atttggagta cctttgtata gcggctttat gtacgcaagt gtagccagtt 1655521 atttgtgcca ggcatggaga aggcttaagg ttgaactggt taagtggccg tctttttttg 1655581 cagttgttcc gcttgccgca gcgatttatt tgaatttttt cacccaccat ttttctatag 1655641 acattcgatg gtggttatca gggcttgtca tcattgtctt ttggcaaaca tgggttacat 1655701 acgaggtgaa tggagctcgt taccgtatgc cgctcgcact ttcttttata ctcatcggat 1655761 tttttatatg gatagcggaa aatatcgcta cgttttttgg agcttggaaa tatccaaacc 1655821 aaatcgatac atggagtctc gtacaccttg gaaaggtaag ttcatggctc ttgctagtga 1655881 ttgttagctt tcttatagta gcatcattaa aacaagttaa ggagcagagt cccacaaagg 1655941 cagagatgga tgaatctttt tcttagcata cgcatacaag ctcccaaata gagtgaaaag 1656001 caacgttcaa atggttgctt ttttctttta tgtaactctg ccggtgagta ttcatcttct 1656061 tcaaatttca tcgcaacacg ataactgatt cagattacaa ctgctttcaa cactttgaca 1656121 aactcatgcg ccgccggcgt tatctcttca aatgaatgtg cgatgacgcc aatatcgcgt 1656181 gtgaccctag gaaagatgtc ctttttaatc aattgatgcg ggacggatga aagtgtaaag 1656241 tttgaaatga tgccgatacc caagttattt ttgaccatat taatcaaggt ttcggcattt 1656301 tgcacagtta agttttcctt taattcgatg ttgtattgcg aaaatgcgtt tgacatcgcg 1656361 atttcatgac cgcctttaca aaaaatgagg tcatcttgat atgtttcaag gtcgacatgc 1656421 ttttcaagtt ttaattcgtc acgctgcggc gggatgacgg ccaccatata gtcgttacac 1656481 aatagctgat tttcaaacgg ttcaaatgga gatgctgcga tcccgatatc aaccgtccga 1656541 tcttcaaccc atccttttat ttggtcagag gttccttcga tcaattctat gcggatcagc 1656601 gggtagtttg atctgaatgc cgcaatcgcc tgtggcatga tatttgttga aactgcagga 1656661 aatgaaccaa ttttcacctt cccgtttaac agcttgtttt cccggttggc tacttgatat 1656721 attttgcttt caattccctt catttgcctc gccagcagca atatttcttt tccgatgtca 1656781 gtcagcatta aaccatgatg tttatccctg atcaataatt tgagctgcag tgagctctcc 1656841 aggtttttta tcgctttact taccgccggc tgagagatga acaattcttt tgccgcttct 1656901 gtaatattta atttctcccc aacttttaca aatatgtgaa gatggttcat gttcataacc 1656961 atttggttat acccccaata ataaaaatgt atttcagtta tacataaatg taacatatga 1657021 tagaaaccag cacgatattt taacaagaaa ggcggcttca ttatggtaaa agttatgctg 1657081 ggaatcatat ctgtcacact tatttggggt tatacttggg ttgcgatgaa agtaggaatt 1657141 catgacatcc ccccgctttt attttcgggt ttgcgcctgt tcatcggagc agttccttta 1657201 tttctcattc tcttcatcca aagaaaaaag ctttcaattc aaaaagaaca tctcaaaagc 1657261 tatatcatca tgagcctgtt gatggggctg ggctatatgg ggattttgac gtatggaatg 1657321 cagtttgtcg attcagggaa aacctctgtt ttggtatata caatgcctat atttgttacg 1657381 gtgatcagcc atttttcatt aaacgagaaa atgaatgtgt ataaaacgat gggactggtc 1657441 tgcggcctct tcggactgtt atttatattt ggaaaggaaa tgctcaatat cgatcaaagc 1657501 gctttatttg gggagctgtg cgtacttgtg gcagcgctta gctggggaat cgcgaatgtg 1657561 ttcagcaagc tacaattcaa gcatatcgat attattcaca tgaatgcctg gcaccttatg 1657621 atgggagccg tcatgttatt ggtgttttcc tttatatttg aggcggtccc ttcagccgag 1657681 tggacatatc aggcggtgtg gtcattgctg tttaatggct tgctttccac cggctttacc 1657741 tttgtcgtat ggttttgggt gctcaatcaa atccaagcgt caaaagcatc catggcatta 1657801 atgtttgttc ccgtattggc cctattcttt ggatggctgc aattgcacga acagatcacc 1657861 atcaatatta tcctcggcgc actgctgata tgctgcggga tttttatgaa tacatttaca 1657921 ttttcacgac ggaaagtgtg aatgatatac atttcccctg tcatttgggc ttcatgtgac 1657981 aggagaagac tattacgaga aagtcttcta gaatcctgac gacagcctat taaacaatga 1658041 aaaaagctaa tgtctgcatg tagacattag cttggctggc gtttaggctg gtgagaatcc 1658101 agatactttt ttattaccat tctggctgat caaactgaaa accgtataga ccttttactt 1658161 taacatctcc gcaatctgga tcttttgtca aaatcaaata atgagtctta taaggcatcg 1658221 tctcaactcg atcagttgca ctaaaatcaa aatgatcccc cgagaagttt ttttcactaa 1658281 cggttatttc atatcctgac aaagtcattc gcatgattct tgcgttaatt gtacatcctt 1658341 cagtatcgaa aatggtgaat ctgtacccaa agtgagatgt ccaatggttt gaatttaggt 1658401 catcagactt cataaaccat ttttcattct ctgtcattgt aaaactcact ttctcctcat 1658461 ctttcacgat aacggccgaa gcttccccta catggatagt caaagccaaa agaaatgtaa 1658521 aagctaacat caacatcttt ttcaaaagag ttcctcccga tatcttttac ttcaatatat 1658581 tggaagggtc ttttctgatc aagacagtct tctccaaatg aatctttagc accatgaaat 1658641 gagccttaat aagaacagtt ttaacccaaa tcaacctcta ttcgaaataa ggcttaccaa 1658701 tctatattct ttttaaaagt ttctgcattt ctttatttag ctcctagaca catataaaaa 1658761 atgctcctat aagttcagga gcactacaaa aaactgctaa agtgttttct atcgatttat 1658821 tgtattcatt agctcaaaga aatattcagg cttttgagtc ttatttagct tataccatga 1658881 acgcaatgta tctggtgcaa atacatctaa ttttttcaat acttctaccg caaattccag 1658941 aggagcaatt cctgatgcag taaccaaatt ttcatcagat actgcaggcc ccttttcata 1659001 gaatgtttct cctttgtaat tagggcagac catattcata tagtcgaggt cattgcttgt 1659061 gtgctttctc gaatttaagt atccttcatt cgcgaggccc aaggttgccc cacaaattgc 1659121 agcaatagtc gtgccgagct ttaaagcgtc gccaactttt ttcaagatcg gctgatgaat 1659181 atcttctccc caagtgtttc ctccgggtaa aatgataaga tcttgactcc caagagtaca 1659241 ttcgtcaaga gaaatatctg gttttatgct taatcctccc aacgtagtta tcatttcttt 1659301 attaacccct actgtaacta cttttaaaga tgctgcatct tgtttaaagt atctccctga 1659361 gtttagttcc gcaattaaat atccatattc ccagtctgac attgtgtgaa atacgtagag 1659421 ataaactttt ctcgtttgca tccaataaca ctccaatcac aattgataaa gctttctaat 1659481 agatgacttt gctgacagtc attgtcagct tttttgttga ttctattctt atgcccttgt 1659541 tctcccaact tataaaaata taagatcaat tgattctatg tttactagcg caaaggggtt 1659601 tgttacacta actgtcatgg gaaacatttc aaaggtaata caaaatcatt tgaatgagga 1659661 ggcctgatga agttgaaaac taaagcgtca ataaaattcg gaatatgtgt tgggctttta 1659721 tgtttaagca ttactggttt cacacctttt ttcaactcaa cacatgccga agcaaaatcc 1659781 atagaagaca caaacatggc aagctgtata acgaataaaa aatttgttca acttgagaaa 1659841 aaatttgatg ccaggcttgg tgtttatgca attgatatag gttcaaacaa gacaatcgcc 1659901 tatcggccga atgaacgatt tgcttacgca tcaacctata aagttctagc cgcagctgct 1659961 gtcctgaaga aaaactcaat tgaaaaactt aatgaagtca tccactacag caaggacgat 1660021 cttgttacat attctccaat cacagagaaa cacctagata caggcatgag cctaaaagaa 1660081 atctcggaag cggctatccg ttacagcgat aataccgctg ggaacatctt gttgcaacag 1660141 cttggcggcc ctaaaggttt tgaaaagtca ctgaaacaga ttggggatca tgtaacgaaa 1660201 gctaaacgat tcgagacgga tctaaactct gcgattcctg gtgatattcg tgacaccagc 1660261 accgcaaaag cactggcaac cgatcttaaa gccttcactt tagataacac tctcacgact 1660321 gacaaacgca tgatcttaac cgattggatg cgaggcaatg ctactggtga cgaactgatt 1660381 cgggcaggcg ctccaatagg atgggaagtc ggcgataaat ccggagccgg aagttacggg 1660441 acacgaaacg acattgctat cgtttggccg ccaaacagag ctcctattgt tgtggcaatt 1660501 ctgtcaaacc gctttacgaa agatgctaat tatgataatg ctcttatcgc tgaggctgca 1660561 aaagtcgtcc ttaacgatct caaataatat gtttagcctt ttgccacaaa ggaaaagaca 1660621 ttactttttt aacttctacc gttcattttt tgatgaacgg ttctttcata agacctctag 1660681 aatcatatat ttaaacacca caaaattaaa cattattata attaacagca agttttcatt 1660741 ttatggaaca agtaaagttt gaatctgaca agaattaaga ctaagcaccc taaaatccgt 1660801 tttcttttct tccaagaata tactccttag tgcaagccat tataaagata caagtgaaca 1660861 tacaatgcag acaactctct taagtctctt attctgtgac caatttgtaa tactcatgaa 1660921 tatccggact cacttccaat atttcgtctc gttcgaagac actaacatat caaaccactt 1660981 gaattaacat aactgaactt gatattggtc actggcagtt tcaatgcaat agaacaacat 1661041 ttgttgtctc agaggttatc tatatgagaa ttcaacaatt tttttataat aattcatatt 1661101 tttgtatcgt tgcacttggt ggatttgact cttttcgtgt atggaaccac acttttattt 1661161 tttcacctct tttgagatca tctgtgttat caatctcact taatcctaca attactatgt 1661221 tatttttaaa cttgttcata agttgtcctt cagaaagatt gtaatcttct tttcctggag 1661281 cttttgtatc ggtaatgaga attgcccttt cattgtcttt aagcacgaca tagcctacta 1661341 ggctctgcat ctttgtttcg tctccgtttt gttcattttt attgcagcct gcaaggaaaa 1661401 taatgagcat aatgagcact atcaagctta ctccgatttt aggcatcttt cttcctcctc 1661461 tttaaactca tctttaaaat aaacaacagg atatcaccca acccatctac ttctttttgc 1661521 aattcataac agcagcatac tcattctcca attcctcaac cttcttttta ttctttctca 1661581 aatatttgca tgtggtagcc ctcgatatta tccgcttact catttttgcg ctttcaaata 1661641 tattattgaa ggccgcttct ttctggattc cagcataaat atacttatcc ttactgtcgt 1661701 ttactatcgc aacttccatt aaaatcgaga tttttacttt ttttatgatc cattattcac 1661761 ttccaaaata acttccaatt acaacataat atatgtataa attgtaaatg gagttgatgt 1661821 aattgaagat taggaaaatc ttattgagtt ctgctttatc ctttggcatg ctaatatccg 1661881 cggttcccgc attggctgct ggcacttcgt ctgaggttgc agtaaaaaat gaagaatatg 1661941 attatgacac tatataccgc attagtcctc tgccaatgga cttccagcca acaatagaat 1662001 acaacggtta tacttatacg cttacacgtc attattttga ttactcaatc gggttttaca 1662061 cggctattta tacaaaagtt gtttaaactt ataaaggagc tttttagctc ctttttctct 1662121 tgttttaagc aaggtatttc tttctatgtg gtcccctatc aaatacaaca tcaacattct 1662181 ccagttctct ttgacacgaa caaaatctaa agtttggttt taaatgctgg taataaaaaa 1662241 ttcactttaa agaagtgccg cccgcaaaat acggcttttg tacactacgc caattttata 1662301 ttgaaaagcc agacctcctc aaagaggttc cagcttttct taatgtgcta tcgatcttcg 1662361 ttagttcaac gggaacttta tcattcggta caaatgcagc ctcccaactt ctagttaggg 1662421 ctgatggcgg aatatctgac ggttctctac acacatcaga cattagaaga tttcaatgta 1662481 gccttctgta ccatgaacgc gaattcgttg cccatctttt atcagcttgg cagcattttc 1662541 aacgccaaca actgcaggta agccatattc acgggctata acagctccat gggtcatcag 1662601 ccccccaact tcggtgacta ggccttttat ggatacaaac aatggtgtcc agcttggatc 1662661 ggtaaaggag gtaactaata tatctccatc ttctaaatcc gcatcttcca tgtttaaaat 1662721 gacacgcgct cgcccctcta taactccgga ggaaacaggt agacctacaa tcgctccggc 1662781 tgggagattt tctcgtttat actcacctgt aacgatttca ccatcagacg tgataacacg 1662841 tggtggagat agtttttcat ataatgtgta ctcgtctttt cgtgtactga tgatttgata 1662901 atccagttta tgtgtgcgca cgacttcgtg aagttcttca aaagtgagat agtatatatc 1662961 ttctttttca tgaataacgc ccgcttctat gagttgttcg gcttctttca gtaaagcctg 1663021 cttataaacg aagtatcgat taaccatgcc gtattttgga tattccctaa acccgctgaa 1663081 attccggatg atatctatcg ctcgttttgt ttctttggct ttttgttcac catccggtaa 1663141 ttgcttcaat cgatctaata actcttgttc tttcttcaaa gcttcctgtc gcccttgctc 1663201 aaatttccga tggccgacat taggctcaaa atttttaata ttattaagaa tcattgggac 1663261 aagtgtagtt ggtttttcgc tccatcgagt tcttgtgata tcaatctctc cggtacatcg 1663321 cattccgtat ttgctgagat aatcatagat cgcgtctcgg gttttgcttc cgccatcaaa 1663381 cttagccagt tcatccaaaa agttatcatc ttttacatgt tgtaagtaat caattacctc 1663441 tggataagga cgaatcacat ctgcgacgtc taatagcgca agacccattt ctgaagtaat 1663501 attatggggt acagattgag aaagcgtatc tgctgcgttt ttttcaccta accactcgtt 1663561 cattttttcg ttaatccata atgaagcatt catagcagtt cgaattagaa ccgaactttt 1663621 tgggttaaat aaaatcttct ttaattcctg aatatcttcc agaataaaac gaaataaatc 1663681 tgatcctgat ttcgtttgga tgttttgttt taactcttct atcgatgttt gactgctctc 1663741 aatcaaatca gacacgattg tcggatcgtt ttcaacttga gccggcatat ctgcattgcc 1663801 tctgctggga tttggtgctg ttttatcatt tggtatcgac tttatgaaat ctcgtcgctt 1663861 tattatggtc ataagtgcgt cttttaagag ctgatcgtgc tgccccatgc cttttaagaa 1663921 aacttctctg ctgtcagggg atgccagatg atgtgtgaca tcaacaaata gccttccacc 1663981 ggctttacgc atgggtgcaa cagtcgtcaa cagaaaaaaa gacaatccca gtggttttat 1664041 gggatccgtc atcatttgtt gatgaccaac agaaatatag acgtgatttt cttggtcact 1664101 cgcttcaggg atggggaata aagtagtgat tggacgactc tgtacaatat aaaaagtatc 1664161 gcgggccaaa caccattcga tatcttgcgg ctggccgaaa tgagcttcga tctgtcttcc 1664221 aatgcgtgcc agctgtaaaa tttgttcatc agtcagtgtt tgagcctttt gctgatcaga 1664281 atcgatctgc tgtgtttctg ttccgccttc ttttcgtccg tagatagcca tttttttagt 1664341 tgctattctc ttatcgatga tttgcccatc ctgtacttta aaacaatcgg cagataccaa 1664401 gccagaaacc agtgcttcac caagtccaaa accggcatcg atggataaca cctttcggtt 1664461 ggaggtaatc ggatcagcgg taaataaaat ccccgaagcc tgagggaaaa ccatcctttg 1664521 aacgataacg gataaataga cttggctgtg gtcaaatcca ttttgcatac ggtaaataac 1664581 cgcgcgatcc gtaaataggg acgcccagca tttactgata tgctgcaaga ttgcatcgac 1664641 gccggtaata tttaaatagg tgtcttgttg accggcaaaa gaagcatgtg gtaaatcctc 1664701 agcagtcgca ctagaacgca cggcataggc atgttcctcg ccaaactggg agagatattg 1664761 agccactgct ttcacaacat cggaaggaat gtctacttcc ataatgattt gccgaatctt 1664821 ccggctgatg ttaccaatct gatctcggtc ctcaactttt agcatggtca attgatccaa 1664881 caacacttgt aacgtttcgt tttgttcgat ggctttttga tatcctactg ttgtgacaca 1664941 aaatccttct ggtacttgta taccttgaat ttttgataat tcccctaaat gtaacccttt 1665001 tcctccaacg agcgaaagct gtgttttttc aatttcatgt aaaccgagaa ccaaagaact 1665061 cattctacat ctccccttca aaaaaaaata ttgacaagag cttcctagca ggatataata 1665121 aaattataag atggatatct ataacttttt aactagaaag cgcacgtagt gtgattatat 1665181 caccgtgtct gtttttgtgc aatataaaaa gaacctggga aatttcacca ggttcttttc 1665241 ttaatttcca tagctagtcg cattaaaaaa cttggtttga gctgattcaa tcctctaagg 1665301 aaatcctaaa gttgggttct ttttgaactt acttgctttg ttcgtagagt ccccattcat 1665361 aaattggact ttttgttctt aacagtccca cctttaacta gtataaagtt atgaggatct 1665421 ggttaactac tagatatttt tattttgaat aaggcttatg tttgataaag aagggttatg 1665481 taaaggtgtc tgttgtgagc aagcgctgac tacaaaaaat tgatagcatt ctcatttaaa 1665541 taccattcta ttaacctata gggaaagttt taaaaccaga tggagaatac cctacctcca 1665601 gcaattccaa ggccgttcac ctagtagaaa acaaccttta accattacta acgattttaa 1665661 taatcattga ttataaaact tctcaaggaa cgatcagcag cccgttagct acccctgatt 1665721 aaggatgatc tgttaccaca ctgttacgtt agaacttcca ctactttgat atccttctgt 1665781 cgccatgact tggtaagccc aattactgcc cagattcatt ccatggctct tccatgcgtt 1665841 cacatgattg ctgaaagtga ttgtagcgtt gcttccggtt ggtctcttcg actggcgaac 1665901 actccagtac tgcgtaaaag tagtgcgatc gccatcaatg gaaggtgcgt tataacgtgt 1665961 agttgtatat atgtcatatg tacccccatc actttttaca gtacctttat acgttccagt 1666021 aggtctataa gtaccccatg aatccactac ataatattct atgagaggtg atctcgtcca 1666081 accatataaa gttaaatatc cattgccatt cggcgcccaa actccggcat tatagtttat 1666141 cgtcctaaat ggcgaacctg tagtccaacc tttaccaaca acaaaatttc cggtattaga 1666201 ccaattaaca ctgtaattcc cgccagaccc attgacagcg tttactatac cgcccccatc 1666261 agtccaattt tgccagtagt ctgtgctagc tgcagaggcg gttgccgaaa acaagctaat 1666321 actcattaaa gctgccgata atccaactaa gaaattcttt ttaaacttaa acatatgtta 1666381 cctcctataa tattttttcc gactttgagg tagcactcgt atacatttaa aacattctta 1666441 attactaacg ccaaagcttt tgatcgtccc cttcagtata ataccacgaa ttcatgagca 1666501 aatattaaaa gtatttgtaa ttcaattaca aatacctaga aacacattat aagtggtctt 1666561 cttccaccat atcctgatcc gagctcgatg tacatgcctt tacggcacac acgaatgtgg 1666621 cgtgtggtgc atcgcctcaa tacgcaaaga cgtttgcctt aggcaaacgt ctttttttgc 1666681 gttatccgat ttttgtgccg tttgggacag gctgatccgg ctgcaaaagg acgacgtcgc 1666741 cctggccggg tatgccgccg aggaccaaga cttccgattt aaatccggcg atccggcggg 1666801 gcggaaagtt cacgactgct atgacttgct tgttgatgag accttccggc ttgtaacgct 1666861 tcgtgatttg tgcgctcgat tgttttatgc cgatttcagt cccaaaatct atcacaagct 1666921 tgattgccgg tactcttgct tcaggaaatt cttccgcttt tacaattgtt cccgttctga 1666981 tatccaattt ctcaaagtca tcaataactg ccatatcaat aactcctttt tctcctattg 1667041 taaaggagat atacaatatt cttttaacta aagagccatc attttttatc cgaatataag 1667101 gtgtttcgat acaggcgggg cggcattcct gtgcttttcg tgaaccatct tgtaaaagaa 1667161 gaaaggtttt gaaagcccag cgcctcgctc acgacggtaa gagtttcatt tctctccatc 1667221 agcattcttt ttgcttcctc aaggcgaagg tcggcaatat agttctgcgg ggacttccct 1667281 gtctgttttt tgaaccagct tgaatagtaa gctgggtgat aatgctcgat ttctgccagc 1667341 ttcttaatcg tcagccgctc aaataaatgg ctgtgaatgt atgcaattga ggcatagcta 1667401 tgggattgaa gcttttcttt tatgtattgt actagcatat gaagcgagtt ggctgttccg 1667461 gcctttgctt cctctgtcag caagtacctg atcgaagacc agaaaggatc gagggcagct 1667521 tcaattcctg atcctgcacg atactcatca attttcattg catgaagcgg aacatccagt 1667581 acaagacatt catttcttcc gatagaacgg aagcgatgct cgcactgcgg cggaatatat 1667641 aaaaaatgat ccggatttaa tttcacctgg cgcccctcag tctcaagatc aatactccct 1667701 tcaagcggaa aaagaaattg gctgtacgcg tgcttatgtg aatgatatag ccgtgtgtat 1667761 gtccgttttt cgcaaattat ctcttgaagc gagtccatta gcaaacccct tcctttggtc 1667821 atcttttaat ccggtaatgg tgttccgata taggcgaaaa gccgattttt ccatataaag 1667881 aaactgccgc cagattttct ttcatcactt gtaaaaacat gcgttccgct ccgttgtttt 1667941 ttgcccattc agtcaacacc ctgatcactt gggttcctgc cccttttcct ctgtgctcct 1668001 cagctacaac gatattacta agtccgccat aaccatcaat gacagaaacc gtgccaagcg 1668061 ctgtcaggct ttctttgtca tacatcttga aaaaagtttt acacggcggc atgcgttcga 1668121 atatgtgttt gtaacctttg tgacgctcgg gtgaaaaccc ttctaattga ataaattcat 1668181 ctatccaaac agatgatggc tcttgttccc acttgtatgt aaatcggctg ttgtcatttg 1668241 ttcggctcat aattgaccgg cacaacgctg tcatctggaa gcactcgtct accttttcat 1668301 aacggctgtc tgccaatgcg tcatcaagcc ctttcggtga tgcgttgcta atatgaaaac 1668361 aaacaggtaa gcctaaactt tgataaaaaa gttcggcctc tagctgaaaa tccccttcag 1668421 gcatatccgc agacgtccat acgctatttg cccttttggt tacgccaaaa ttcgctctga 1668481 gaagccattt ccctatgctt ttttgaaaat aagccggcca tgaagctgcc gctaatcgtt 1668541 caatcttgcg aatgtcatcc attgcataat gcctctcccc tatgtatact cccttgatat 1668601 tatacaatat tcagaaatat aagacatcca tttatttgtt tacataatat ttttattgtt 1668661 tattaataat cctgacaaaa atgtccgaat tgaaaatgac aggctttcta aaatgtcctc 1668721 ctcacgttca aatgcttctt ttgcgattaa aacagtaaag ccatgcagca gacttctgag 1668781 cccccttgtc gcatgaatgg cagtcttttc acttgcatag ccgttttcaa tgagcagctt 1668841 cgtcacaaga cagacaattt ggtcagagac gatttccgtc cgtttgtcgt gaaccttaag 1668901 aagagccgct tcataatatc cgggattttc aattgcaaaa tcaacatatg catgagctaa 1668961 agaaagcatc gcggaatctc cctttcgttc ggttacggag tccgccattt gatcaaaaag 1669021 ctttgtcagt cctctgacag caagttctgc tctgatcgct tgcagcccgt tgatatggtt 1669081 atacaatgac ggggggcgaa cattcatttt tttagaaagt gcagcaagtg agacaccatt 1669141 taccccttcc tgatcggcaa tctctgctgc agcgtctaca atcatttttt gggtcaaacc 1669201 tattctcggt gacatgctca tcatcctttc tttgcttttt ggatcgcctg tctcatccgc 1669261 tctgaaggtg atcgcaggaa ttttccatgt ccgacagcga gacaggaagg cgccttatcg 1669321 gcgagcaatt gtgcactttt gatggcctcc tccttattcc atgtggcgaa agcgggaaaa 1669381 ggaaacgccc attttatctg acctgataca gcgattcctc cgcgcaactg aaacgcatct 1669441 cctgctatta aagtgccgtt tcttgtatca agaaatgaca tgctgcccgg tgtatggccc 1669501 ggtgttggaa tggcaagcag agaaccaatt gtttcaccgc ccgtcagcag ttggtgaggc 1669561 tttgtttgta tgtgtttcgg aatacctcct tttataggcg tctgcggctc atcttgccgc 1669621 aaagatgtgt caccttggag caagaatgaa tcccgttccg agatcatgac ctttgcatgc 1669681 ggaaatgttt gtgccaatgt atccagtgat ccgacatggt ccccatgtgc atgagtcagt 1669741 aaaatatgct gaagcggttt tccaagctga ttcacagctt gaataatccc tttatagctg 1669801 cctggcagtg cggcatcaat aagggtgact tcgttttctt cctctactaa atagcaatta 1669861 accggaaaca atgctggaaa aaaagtcagc tgccaaaccg tttggtactg agtaattctc 1669921 atctttttat tcctcctaac aaaaactaat ggtgttagtt ttattattaa ctaacaccat 1669981 tagtttttca agagtttatt atttttttat cgctacataa atgttaactt gtgctcgctg 1670041 tggcactgcg gcattttgat catacatctc aaagtcacct gtaaacgtgc gcagatgccg 1670101 cttatcccaa gtccaaattt ccttccacgt ttcaagcaca atctcttcaa taggaccgat 1670161 tctggaagtg aaaacggcgt aagcggaagc cggcaaatca atattttcat atggtcccgg 1670221 aagaatgtcg tcgtattcct gaaacgttcc gactgaaaac gtataaaacc cattcgtctc 1670281 ttgttcataa ttcgaatata aggcaataat gctcttgtct ttttcagcct gtgataaaag 1670341 agcgctcata tcctgcttcc ataattgatc ccacagtgcc ggaatcctcc tttcttccgt 1670401 catttccagt gcgttgcttg tccgttgtga tagtccggca aatcgtttca ggtctaagtg 1670461 tgttatatgt gaaaagccca tacgatctcc tccttttttt aagattatag acaaagaaac 1670521 ctgacagcag tgtgtcaggt ttcatatatt ttttgcatgt gatgaatggt ttcttttact 1670581 ttatccctta tatgaagagg ctgcagaacc tcaatatcct ttccgaactg gagcaaaaaa 1670641 ccgatcagcc attgatcttc tggaagtgaa atcaccgcct ggcagatttc atcttcctca 1670701 caacagtgaa ggacatcata tccgaaccat tcacctatac gctgacgtgc tgacggctga 1670761 acaagaataa ccaattcagt taaacggtcc ttttggtacc aactcttatc ccatggcaaa 1670821 gtgtccagct gaatgtcttt tctgataaat gtctgatgta agatggccag atctttcatc 1670881 cggttcagtt taaaaaagcg aaaatcattt cttaccaggc agtaggcata taaataccag 1670941 tgccccgcct tgcaaaccaa tgtataaggt tcagtttccc gaagtagtgt ttccccgctt 1671001 gcgcttgtat atgtaaaaga tatcgttaac aaccgatcga tggcagcgct gattttctcg 1671061 cgcagcgtct tttgatcctc agtatggccc caagccgtca tgtcaataaa ccatttttct 1671121 gtttggtgct taaatgcttg agtagattgc tcaggtataa ggtgtttgat tttttgatag 1671181 gctgtgctgt gagaaacggg ttcatacata gatgaaacgc tttgcaaagc ggaagcaatt 1671241 gcaaacaatt cctcctcctt cagccactct ctttcaagcc gatacgtttc catgatgcca 1671301 attccgcccc cggaaccctg tgaggtcaca atcggaatac cagccctatt gatcgtctca 1671361 atatcacggt aaattgttct gacagatact tcaaacagct cagcaagctc tgcagcctgc 1671421 acttgttttt tgctgatcaa taacacaacc atcgctaaca aacgttccag tttcattctg 1671481 cgcacctttt cttcttgtat tttccaacaa aacaatcata acattttgat aaagcttggg 1671541 catatctatt atgcggcgga atacacctcg catatgctat gaaaacaggg gtttcccctt 1671601 cttttttgtg ttcagtattt atttcagcta ctatttccga ccggataagc atacacttct 1671661 caacggaggg gatttcacat catgcatctt acacttcaga gcgtttatcc tgccataatc 1671721 atcatctttt ttctgtataa aaaaattaaa aggtccatcg gataccagcc gctgaagccc 1671781 cgctggctgt tcacccgtat cattcttttc tcgctgtttg cttttggact ttcaatcttc 1671841 agcgccattc accctttttt atatggatat ctcattttgg gcattcttgg cggatggctc 1671901 cttgtctttt tcgctaagaa aaacatctct tttgaaaaac gcagaggaaa gatctatttt 1671961 cggactcata tttgggtaga ggtgattctc ttaactttat ttctatcaag atttctgtat 1672021 cgagtgacgg agctttatct tacctcacct gatctaaacc gccttggatc atacagtcag 1672081 tcaatcggaa cggaccctct gacaattggc gtctgttttc tgatagccgt ttattatatc 1672141 ggtttttctt cttttatcat caagctcagc agaaacgaac ttgaacagca cgaatacaat 1672201 aaagaaaaag acatccttgc ccgctaacag cgagttaagc aaggatgtct ttttcaatca 1672261 tgctgtgtat gatggatcat ttgctgaaga acatctaaaa catgttcatc ctccggagag 1672321 taataaatcg atgttccttc tctgcgcgat ttgacaagcc ggagattttt taaaaatcta 1672381 agctggtggg acacagtgga ttgcagtaaa ttcagctttt ctgcaattcc gtttactgca 1672441 tgctcacctt gggacaataa atggagaatt ctgattcggg taggatctga aagcgctttg 1672501 aatgtttgcg cgactagaaa cagcgtctcc tcgtccagat cagcagccga ttgttccgtt 1672561 tctctaaatt cagtcatatg tatcaccttt ctttattcat agttttatct tataacaaat 1672621 gcgcttgagt gcaaaccagc ctgcttgtat tccatttcaa tctcatagtt taaatttatg 1672681 tttcaaatca ggtttttact tggtctgata taccctctta tgtcataata aaaaaggtca 1672741 tactgctcca aacattgagg gtgaaacaca gtgaagaaaa agagaaaagg ctgtttcgct 1672801 gctgcgggtt ttatgatgat ttttgtcttt gtcatcgcct cttttttatt ggtcctgctt 1672861 tttttcaacc gggatttaat caaaaaactt ccgatcgata cgaaaacgat tgttttggaa 1672921 cgtttaaccg attacaaacc cttggtggaa gaagagcttg aaagccaagg actctctaat 1672981 tatacatcac tcatattagg catgatgtat caggagtcaa aaggaaaagg caatgatccc 1673041 atgcagtcct ctgaatctct ggggttaaaa cgcaatgaga taacagaccc tcaactcagt 1673101 gttaaacaag gcatcaagca atttaccctc atgtacaaga ccggtaagga aaaaggcgtg 1673161 gatttggata ccattattca aagctacaac atgggggcag gttacattga ttttgtagct 1673221 gaacatggag gaacgcatac tgaggaattg gcaaaacaat actccgagca gcaagtcaaa 1673281 aaaaatcctg atctgtatac ttgcggggga aatgcgaaaa atttccgcta tccgtattgc 1673341 tacggtgatt atacgtatgc agaaaaagta aaagaaaaaa caaaaactgt tgaagaatct 1673401 ttgcaggttg caacacttga aaccatggaa tccaaggctc atgaataaga gtctatcaat 1673461 ttactgacaa aagcccaaaa atgaatttgg gcttttgcca tgtttacacg taaaaaaagc 1673521 catactgagt atggctttta ataatacggt gaaatcatca aatatacaat aacgcctgta 1673581 aggcttacat acagccatag aggcattgtc catctcgcaa tttttttatg gcgctccacc 1673641 tgcatgctga agcctctgat cagcgtaaac agcgcaagcg gcacaataat tgcagaaagg 1673701 cagatatgtg taattaaaat aaagaaataa atcgggcgca taataccttc tccgccatag 1673761 agcgtgtttt ccgcaatcga gtggtacgtc acatagcaaa tcaaaaatag taatgttgtt 1673821 gtgaacgcag ccaaaataaa gcgtttgtga gctttgatat ttttctgttt aatcataatc 1673881 agcgcggcca ataagaagat aaacgtaaag ctattgaata tcgcattcag cattggcaaa 1673941 atgtgaatat tcgcatggct gaactgatct aatttaggca taaaaaacag cactgcgatt 1674001 aaaccgttaa tcagaactgt cagcgtaagg acaatccccg tgtaattttt cggtttattt 1674061 tctgtttggt tcatttggtg acctctccta atttgtactg gctatccaaa tcgtatgcaa 1674121 attcaaagaa gatgtcaacg gtttcgattg cttcgtcaga aattagacac acttcaaagg 1674181 ccggaggcta ttagccccgg cctgttaggt ttacgcctct tttatcaaat gttcaatgac 1674241 cttatgttca ttttcattca gcaggttctt ttgaattttc gaatgaatgg gtttattcat 1674301 atgctgatcc aagatatcgg ccgtttcttt atccccggca ataaccattc gttcccatct 1674361 tttcgcggca gctttttgat caaggctggc agccagccgc ttatacagtc tcgattggtt 1674421 ctctgttaca tgttccctca tccggttctc ttcaaatggt ggcgctttgt ctacagcgga 1674481 atggctattc ttccaagact cattgatcat atcatactca taacgctcca ccgcctcaat 1674541 ttttcctaaa acagtttcaa taattttcac ttcatgctgc tgagttaaaa taaacgccgt 1674601 acttgggtat gtctggcgca aaccctttag ctgatccagg acagctgttt cttcccagta 1674661 aaatcttgta tctacaggga cttgaagctt aataggttcc catatgccgc tgtcggaaac 1674721 aaaaaacacg agactgcggg gcatgtcttt tcccattgca ttcaagtatt gattcatttt 1674781 agccctgatt ccatccagac acttttcctc ctctggatca ctagctgcca aatactcttt 1674841 taatcggctg aatcctgact ttagggcaat cttccattct cccccctgct gctctggatc 1674901 tctcatgtct gtattgagat acagagagag aattttatcc ggcggttcca attggacata 1674961 ctgtaatttg ttaatcaatg aatcaatcgc cattccgatt cctccttttt cacaggttag 1675021 ttttcttttt cctctcttaa aaacgatcaa acctgacttt ccgctaattt ctagtaataa 1675081 tggaattgtt gtttacaata cgcctctctt ctaatacaat tggtaactgt gtttctaagc 1675141 tgttttttga aaggagtttg atcttgttta ctgttaaaga aaaaaatcgt caagagcttg 1675201 aggaagaact aaatgattta gaatttcaaa tttatcgcat gcaggagaat atgaaggatt 1675261 tatctaaaga tgccaaagtg cttggtattg atcaatcgaa acatgatgag tggatgattg 1675321 tttcctcgat tgatgatggc caaacatgca aaattatgct aactgattgt aaaacggcat 1675381 accgaggaaa aggctgtttt tcacttgtag cgtcttacaa ggacgatgcc attcatatag 1675441 gggatataaa aggccctccg aatcacgggt ttggctccat ttgcatgaaa tatttaaaag 1675501 atattgcaag agaccataat ataccgaaag tcaccggaga catcgccaaa cgggattgga 1675561 atcatgtaga ccggctgatt cacttttatg aaaaacatca cttcaaagta tgtatcgatc 1675621 atgataccca atccggcagc attaagtggg ttgatttgta aaaaagtctg gaagaaagag 1675681 ccaagatatg ctgtaatggt ataaaaccat tgatggaggg ttctatgtac gcctcaaaac 1675741 tgaaaaaggg agacgaaatc cggatcgtgt ctcccgcgac cagcatgtct atattatcaa 1675801 atgaagcaaa aatccaagca aaaacggcgt tagaacgctt aggttatcgg gtaaccatcg 1675861 ctgaacacgc aaatgaatgt aacgaatttg attcatcctc tatcgagtca agagtccatg 1675921 atctgcacgc tgcctttttt gatccaggcg tcaaagcgat tttaacgaca ctcggagggt 1675981 ttaattcaaa tcagctgctg cgttatcttg attacgagaa aatcaaacga catccaaaaa 1676041 ttctgtgcgg ttattccgat ataaccgctc tttgcaacgc tatttatcaa aaaacgggtc 1676101 ttgttacgta ttcaggtccc cacttctcaa catttgcaat gaaaaaagga ctcgattata 1676161 cagaggagta ttttctttct tgctgcgctt cagacgatcc gtttgaaatt cacccctcaa 1676221 gtgagtggag cgatgatcgc tggtttttgg atcaagaaaa caggcgtttt tatcctaata 1676281 acggccctgt tgtaatccaa gaaggttatg cggaaggtac tttaattggc ggaaacttat 1676341 gcacgcttaa tttgctgcag ggaacggagt attttcccga aacagaacat actattttat 1676401 tgattgaaga tgattatatg tcagacatcc atatgtttga ccgcgatctg caatcactca 1676461 tccacctccc cgctttttca catgtaaagg cgattttgat cggcagattt cagaaagcat 1676521 caaacgtatc aatagatctt gtaaaagcca tgatcgaaac aaaaaaagaa ttatccggca 1676581 tcccgatcat cgcaaatata aatgccggac atacctcgcc aattgccacg ttccctatag 1676641 gaggaacatg caggattgaa gctatttcgg gtacatcacg aatatggatt gataaacatt 1676701 aatcagcttg taaatttttt tacaagcttt tttagcgcaa tcggctatgc atgccgcacg 1676761 agacatgaca aatgtcatat aggaggcatg atgtgtgcta ctacaaaaga cttctctcat 1676821 tagcgtatac tgaaccgaga cacacaatga gaggatactt actatgactg aacaaaccat 1676881 tgcacataaa caaaaacagc tgacaaagca agtcgctgca tttgctcagc ctgaaacaaa 1676941 aaacagcctg attcagcttt taaacacgtt tatcccattc ttcggcctat ggtttcttgc 1677001 ttatctcagc ctcgatgtct cctatcttct tacgttagca ttaacggtga ttgccgcagg 1677061 ttttctgaca agaattttta tcatcttcca tgactgctgc catcaatctt ttttcaaaca 1677121 aaaacgctat aaccacattc tcggttttct gacaggtgtc ctgactttat tcccgtatct 1677181 tcaatggcag cacagccatt cgattcatca tgcaactagc agcaatctgg ataaacgcgg 1677241 aacaggagac atctggatgt taacagtaaa cgaatataaa gctgcatcca gacgaacaaa 1677301 gcttgcatac agactttata gaaacccgtt tatcatgttt attctcggac cgatttatgt 1677361 ttttctgatc acgaaccgtt ttaacaaaaa aggcgcaaga cgcaaggaac gtgtaaacac 1677421 ataccttacg aatctggcaa ttgtcgcgtt ggctgccgct tgctgtctga tctttggctg 1677481 gcaatcgttt ttactggtgc aaggcccgat atttctgatt tcaggttcaa tcggtgtttg 1677541 gctgttttat gtgcagcata cctttgaaga ttcttatttt gaagcggatg aaaactggag 1677601 ctacgttcag gctgctgttg aaggcagctc attttataaa ctcccgaaac tgcttcaatg 1677661 gctaacaggc aatattggtt accaccacgt tcatcatttg agtccaaagg tgcctaacta 1677721 taagcttgaa gttgctcatg aacatcacga accattaaaa aacgtaccga caatcacctt 1677781 aaaaacaagc ctgcaatcac ttgcgttccg tctatgggat gaagataaca aacagtttgt 1677841 gtcatttcgg gctataaaac atatacctgt aagccttccg cctgattcac cagaaaaaca 1677901 gaagctgcgg aagaatgcct gatgataaag gaggtcttct aatatactag aaggcttcct 1677961 ttttattgtt ggagggtgca ttctggcttt cacaatgata aagttacaag taagatgaaa 1678021 agctgaaaat gaggtaagat catgattaaa aatcatttta catttcaaaa actaaacggg 1678081 attacgccct atatatggac gatatttttc atcctcccct tctactttat atggaaatca 1678141 tcatctacat ttgttattat tgtcggcatc attttgacgc ttttattttt ttcggtatat 1678201 cgatttgctt ttgtctcaaa aggctggacc atttatttgt ggggattttt attaattggc 1678261 atttcaaccg cctccattac tctgttcagt tatatttatt ttgctttctt tattgcttat 1678321 tttattggaa acattaagga acgcgtccct tttcatattt tatattatgt ccatttaata 1678381 agcgcggccg tcgcagccaa tttcagtctc gtattaaaaa aggaattctt tctgacacaa 1678441 attccttttg tcgttattac cctcatcagc gcaattttat tgcccttcag tataaaaagc 1678501 cgcaaggagc gcgaacgact tgaagaaaag ctcgaggatg caaatgaacg gattgcagaa 1678561 ctggtaaaat tagaagaacg tcagcgaatt gcccgcgatc tccatgatac gcttgggcaa 1678621 aagctttctc ttattggttt aaaaagcgac ttagcaagaa aattgatata caaagatccc 1678681 gaacaagcag ctcgtgaact gaaaagtgtt cagcaaacag cgcgaacttc tttaaatgaa 1678741 gtaagaaaaa tcgtttcctc tatgaagggc atccggctca aggatgaatt gatcaacatc 1678801 aaacaaattc tcgaagcagc tgacattatg tttatctatg aagaagagaa atggcccgag 1678861 aatatctcat tgctgaatga aaacattttg agcatgtgct taaaggaagc tgtcacaaat 1678921 gtcgtcaaac acagccaggc taaaacttgc cgagttgaca ttcagcagct ctggaaggaa 1678981 gttgtgatta cagtgtctga cgatggaaca ttcaaaggag aagaaaattc cttttcaaaa 1679041 ggacatggct tactcgggat gagagaacgg cttgagtttg caaacggaag ccttcacatc 1679101 gataccgaaa acgggaccaa gcttaccatg gcaattccta ataattcaaa ataaacataa 1679161 aggatggctt atatgattag tatatttatt gcagaagatc agcaaatgct gctgggcgct 1679221 ttaggatcac ttctaaacct cgaagacgat atggaagtcg taggcaaagg tacaaccggc 1679281 caagatgctg ttgattttgt caaaaaacgc cagcctgatg tatgtattat ggacattgaa 1679341 atgcccggaa aaacagggct tgaagctgct gaggagctaa aagatacagg ctgcaaaatt 1679401 atcatcttaa ccaccttcgc cagacccggt tactttcaga gagctattaa agctggcgtt 1679461 aaaggctatt tgttaaaaga cagtccgagt gaagagctgg ccaacgccat ccgtagcgtc 1679521 atgaacggaa aacgcatcta tgcacctgaa ctgatggagg acttatacag cgaagctaac 1679581 cctcttacag atagagaaaa agaagtgctc gaacttgtgg ctgacggtaa aaacacaaaa 1679641 gaaatcgctc aggaactcag catcaaaagc gggacggtgc ggaattatat ctcaatgatt 1679701 ctagaaaagc ttgaagtgaa aaatcgaatt gaagccatta cccggtcaaa agaaaaaggc 1679761 tggtttaaat aaaaaaggat cttggcatct gccaggatcc tttttgttaa cctgaaattc 1679821 ccgtttgaga acctcgtcgc aaccagaatt aaattgatcc atatcctcgc tcctacgccc 1679881 gctgaacgat tgtttggtta acagcccaat aaaagactgg attgaatgat atccctgtta 1679941 aaatggtcgg ccattgcaca tcagcagaat ttctgatatt gattatattg tattttcagt 1680001 atgacaaagt tgtgccactt cgctcccgaa gctgccatgc ccaactgcaa gagcctaata 1680061 tcacaataaa aaaccgtctg aaatcaatcc gattccgtaa atggtatctg ctacatccaa 1680121 ctgcttatta tctgccaaaa acaccagctc gtttcgctga tcaaagatag taacaaccag 1680181 ctataaatgt catgatgccg aatgtctctg taatgtggaa tcaatctttt aacccgagag 1680241 cccctgaatc gcacataaag aaaaacggga ccactttctt ttatcagcat atgatataaa 1680301 cagctctaag cagaacaaaa aaagacacaa gccaaaagct tatgtctttt atcacaatct 1680361 atattattag tttaagactt taacacttac agttttgacg ccccaattag aagcatcact 1680421 tttacttggt acaaatacgt cgattttatt tcctttaata gcgccgccag tgtctgctgc 1680481 tgttgcttcc ccgtagcctt caacatagac tttagaacct agcggaatta cattaggatc 1680541 aaccgcaata actttcgcgt tcgggttctt atttaagtca atgcctgtag ctgtaacgcc 1680601 ggaaatgccg ccgtcgttag cagtgtaagc agtagcagta actgttagtt cttttgaagc 1680661 ttcttgatta tttgtatttg attgaacagc cttctcctct gtgttaacag aagtttctgc 1680721 ctcagccttt gtttcttgtt taggttgctg ttgtacagct tcttgtttag gttgctcttt 1680781 ttgcacagcc tcttgttttg gcgcagcttg aggtgcgttt gtttgcgcat tctcagtagc 1680841 tgtgtttgct gctgttgcct gaccttttac tgaaagagtt gatccagcat agatcatgtc 1680901 agagcttaag ttattccaaa ctttcaggtt gttgactgtc gtgccgaatt tttgagcaat 1680961 cttagaaagc gtatctcccg ctttaattgt atattgccca gtcgtggttg tttcttctga 1681021 agaaatggtc agtttttctc ctgcaatgat tttatcagaa gttaacttgt tccattcttt 1681081 taagtccttt aggttcactc catttttctg agagattccc cagagcgtat cacccttttg 1681141 caccgtaatt tcttttgcag aagcgtgagc tccgaatgca gttgttgaaa gtgcagcaac 1681201 tgccacaaag gacataatcg tcttcttcat aagtaaatcc tcccttgtta gctttttatt 1681261 ggcggctaac aggtgatatc gtaacacacg taaatgtcaa atcaataaca aaaagatatg 1681321 atttagatta cagttccttt acatgaagga tttctctctg atggaaagac ttgctgaacc 1681381 cttgatataa taggcttcgc aggtcttttt attttgaggc gaaacagaga aaataaaatg 1681441 tgttttttat agaaaaaaag attgtttttc tgttttttta gtctgtcatc cttgcataag 1681501 cctgtatttc ttgtaaaaaa agccggccgt attttgctct tttttgttct ccgactcctt 1681561 ttatagacaa aagttcatca tcatttacgg gctgttttcc tgacatttct tttaacgttt 1681621 ggtcagagaa aacaacaaat ggcggaacac cctgctcagc cgcaatttct ttccgaacca 1681681 tgcgcaatcg ttcaaatagc tcgtcatttt cagtaatcgc tgccgctttt aacgcttctt 1681741 ttctcgctac tgataattct cctttcagca cattccttcc tttactgctg acaaaaagag 1681801 tcggaaacgt tccgtctgac atcctgatga agtcgtcaga aataagaaat tcgataaaat 1681861 cactgatttc gccaacggat tggtgtttta atatcccgta tgttgaaagg tcggaaaagc 1681921 cgttttcaag aactttttta tttttggagc cggcaagcac ctgggcaacc atcgtcttgc 1681981 caaaccgttc tttcatgcga atgatacaag ataagaccat ttgcgcctcc cgcgtcacgt 1682041 catgggccgc tcttgtatcg gtacagtttc cgcactgtcc gcacgcatca ggctcctttt 1682101 ctccgaaata cataaggata aaacgctgca gacaatcttc cgtatgacag tagtcgacca 1682161 tttgtctcag cttttttaaa tcctgctttt gtttctcttc atgttctgat tgctcaatta 1682221 agaagcgctg caccataata tcctgcggtg aaaacaggag aacacattca ctggcaagac 1682281 cgtcccgtcc agctcgtcct gcctcttgat aatagctttc catatctttc gggatttgtg 1682341 catgcagaac aaatctgata tttgatttat caatacccat tccaaaagca gaggttgcca 1682401 ccatcacttg aagctcatca ttaagaaatc tttcctgctg ctcttttctc acatcatcag 1682461 ccaaacctcc atgataccgg cctgccctga cctgatttcg tttcaatctc tcatatatcc 1682521 gatcagcttc ttttctggtc gctgtataga caattcctgc ttcatgcctg ttgttttgca 1682581 catattcgtc tataaaccga tctttatttt ctccttttac tactttaaag gttaaattct 1682641 ctcgggaaaa tccggtatat accgtgtttt ctttttgaat atgcagctgt ttgcaaatat 1682701 catcatgaac ctcgggtgtg gctgttgctg ttaacgccat gatgacaggc ttgtcgtgta 1682761 attcacggaa caagatttca atattcctgt agcttggcct gaaatcatgg ccccattgag 1682821 aaatacaatg cgcctcgtct attgcgacca aaggaacatc tatgccctgc aaaatccgga 1682881 taaactctat ggacgttagt cgctctggtg taatgtaaaa aagcttataa gccccttctt 1682941 tgagtccgtt cagcctctca tatatttcct gattggattg tgtgctgtta atgtaggcgg 1683001 cgttaatccc cgcttcttct aacgcatcaa cttgatcctt catcaaggaa atcaacggtg 1683061 aaatgacgat cgtcgtccct tcaaacatta atgccggaat ctgatagcaa atcgatttgc 1683121 cgcctcccgt cggcataatg caggccgtat tttgcctcgc ttccgtcacc aagcggatcg 1683181 cttcatcttg gccgctccga aacttctcat aaccaaaata atgagccaga agggattggg 1683241 ctctatgtaa cataacgtgt aaacctcgct tttccttgaa tttctcccat catatcataa 1683301 aaaagcggcc ttcatttctt tcacacaaaa atggaatatt cactatacca aaccttttta 1683361 gataaaataa aaagccattt ccgaaaagga aatggctttc gctacgtctt gccgtatgca 1683421 agtaagaaag ttttaaacca ccactcctca aagtgggtgt ttgcagaaac gttcctgtcg 1683481 tcctctgcaa tggaggcatg acattccggc ttcgatataa aactccctat tacagcttaa 1683541 aggttaaaac ttaattaaca atacgcacaa agtagcttct ttaatatagt acaccatcag 1683601 gcgcttttaa tcaagaggtc agaacaattg tttagaaaaa ctttttccag tgaataaaac 1683661 tgttttttct ccaaaatacc tgacaattcg acaaacaaaa aatatattac aataaaaaaa 1683721 atagccttta ttgctaaaag cgaatgatta ttttcttcta tattaatgtg tatatacaaa 1683781 aagactccta tttgtaacga taggagtctt ggctttatta gaattttgca gcaagatctt 1683841 ttgcttcttg taaacctttt tcaacgattt cttgcgcttg atcaggtgct gcgttatgtc 1683901 cttcgatgac aactgtgtgc aagtcttgaa caccccagaa accaagaact gttttcatga 1683961 agtttaatga catttcaagt gcagccattg gtccttctga gtagacaccg ccgcgagcgt 1684021 taagaagcgc aacttttttg ccgcccatta aaccgactgg tccttcttgt gtgtatttga 1684081 atgtaacgcc tgcgcgagac agataatcaa cataagtatg aagcactgct ggcactgtga 1684141 agttccaaag cgggaatgcg aaaacaactt tgtcagcttt tacaaactgg ttcagatatt 1684201 tgtcagcaat tgctgcttgt tttttctcat cttctgtcat ttccattcct tgacctgctt 1684261 taaatgttcc gttaatcata tctctgccaa ggtaaggaag gttttcctta tgaagatcta 1684321 attcaaccac ttcatcatta gggttgtttt ctttataagc agctaagaaa gcttcgtaaa 1684381 gtttagttga aacgccttct tcagctgtac ggtcgcttga ttttacaaat aaaactgtag 1684441 acatttgtat tcctcccggt aaacttttta tatttactta caaatagtat gttactttct 1684501 tttttacgta aagtcaatca ctttattttg aatatgagat tttttttcaa aaaaaagcaa 1684561 gtacatctaa tatcggtgta cttgcttggc atttttactt cgaatcttgt tcacgatcca 1684621 agatttcata cgtctgcgag cttttttgat caattgtttc tttgttggat aagtctttta 1684681 cctgttcatg aaactctctt tcataagaag gagcatctgt ctccagatca tcctccacat 1684741 cagcttgggc ctcaactgtc attcttgcat aaggaacagc ttcaagtctt tcgtaaggaa 1684801 tctcttggcc ggttttttca cacacgccat aagttccgtc tttcatcttt tgtaatgcac 1684861 ggttgacctc ctctaacagc tcccggtcaa tctctttcac tgtttggtct gtcatccggt 1684921 ctgtgacgag cgtcccgtgg tctgccatat ggttgtcaac cccattggaa agctccccca 1684981 cttcttccgt cattgattct gtttcctttt tctcgccaga caattctttt tgcatatcga 1685041 gcaatttatg atagagatgc tgtgtttgtt cttttgtcag tgccatgtat atcctctcct 1685101 ttctatcctg tttcccgttt tgccttctgt caaacatgga aacatcgatg gaaagatgag 1685161 ctactgcctt tttgaacgga tcgtgaccgc tggcgtcgat ggtgcttcgg gttttcgttg 1685221 gcactttttg tccttctctt ctggcggtat ataataggtt gcgcctatat ttaatctgcc 1685281 gctcagttca tcaatggtca gctcgccgaa ttcaagatga tagtcaactt tttcgacatt 1685341 cagcgtttca atatgtatat aggtttcttc agactcttgt ttgctgcttt gtttttgttt 1685401 ctcaatcact gagagtcttt cttcacattc acgcagtttg tcaagttctg gtttcaagca 1685461 atgcctgatc agcgaccgga acattttttt catgacatca cgaccctttg catactcctc 1685521 tttcgtctac atatataatg aggtatatcc catagaaagg agaggttttc atgcttccga 1685581 ctaacatcaa tatttctcat ctcaagacta actcgatagg caccggctca tcccttacct 1685641 ttggttctgc ggagttaagg aacaggtgct ctgctatcaa aagaaataac ggttttgggg 1685701 aacaaaatgc agatggtatt gttatggtca ttccgattga atcaattgat gaccgtgatg 1685761 tgtcagatgc actcagtatg aaaatcaatc atcaataaca atggttttcg cttgaccttc 1685821 gtctttttga atagtgatgt ataggattcc gtctttaaaa atggcattca tctttccatg 1685881 aagatgatcg gaaagcggaa ttttcttttc aaaacttccg tatttccctt ctttttggcg 1685941 aaagtcctgt tcattaaaat aggaaaagcg ctgccccttc accactaaat aatctccgta 1686001 cgataatatg tgaacgtctt gtttacggta gcctggaaga taaattaaaa actgcacttc 1686061 cgcaacggta tctacaatat ccatgctcgg aaatgaagca tctcctttcc ctcgctgatc 1686121 ttgctgcgca aacggaaacg gagattggcc atttgtcata aaaggggttt tttggtcttc 1686181 atcaaatacc tgtttccaaa agtcaccgcc gtacatctgc tgtgcgaatt ccatccactg 1686241 cttcatcttt tcgaaatcca tttgaagccc cctgtcttaa catactttat aaccgccagc 1686301 atacaactat agaaaggagg tttgcctgtg gttcaaccaa ctccgtatat caatattaat 1686361 attttcatgc tgaaaattaa ttcctttgaa aatgcttcag cggttaacgt aggacaaaat 1686421 ttattggcag aatggcaaaa ttcagataaa aaaaatcaag gctacggaca gaattttgga 1686481 gatgcgagcg gatttatggg cacgagaagc catgtggatg acagagacca aattgattct 1686541 ccggcctctt ttgaaagtga agcggttaac tcctcaatca aaaggaagtg atgagatgtt 1686601 cttttcaccc tccgtcgtaa atgtcggcgg atttaaaatc aatacgatgg atcgaggttc 1686661 ctctttaaca ctcggtccgt atcagcaggt cgattacttt ttatcagcta aaataaatca 1686721 agggtttgga gaagaaaatg gcgactttac tcctcttgtc gtgccgattt caaatgtatt 1686781 agatgcagat cttgttgatt cgaactcagc gaaaaacagt gtggtgtaat aagaacaggg 1686841 cgcacatgcc ctgttcttgt ttttatatat aaaaaaagcc taaccatttt ttgaacggct 1686901 ggctcatcaa atattcagct gcacaaatgc tttgtcagca ccgcctgaac ctcgcttaaa 1686961 tcggtgtctt tcgcaaattc taattcgaaa gttttgcttc ttgtcatcaa taaaagccca 1687021 gtgtccggat caaacattcc cgcttcttgg atggcaaagc tttcaattgt tttatatgga 1687081 agaaatacac gaaccttctt tttagaaaac attttattgt caaagaaaat gatccgctta 1687141 tttgtaaagc aaatttggtc cactcggagc ttataaatcg attcaattct ttccccttca 1687201 acgagcaaag cctcaagctt ctttgcgtcc gttgatctgc taacagaaaa aatacccaat 1687261 gaagaacccc tctttctgca tttatctatt tgttttatca ttcactacat aaaaataagt 1687321 cctttatccc tatataagaa tacgacatag aagacattta aaccattacg aacagattac 1687381 atttttcaaa tttttgattt gttttttggc ttttaagctg ttgtcatcaa gtaatacgca 1687441 catatagaga aaaaagtttc aatattcagc aatgttttta taaaaaagtg gtttttaatg 1687501 atttttttaa ttttgtttta tatttcctgt tttaaccaca aaaaaaccgc agctgagctg 1687561 cggttttatg tatcgactgc ttttaacaaa atctgtttga tgcttcaagg aagcattaca 1687621 tctcttcgaa gtattcttta taatagccgc cgactttatt cgtattgtcg accacaaaga 1687681 gaaactcctc tgtttcattt tttacttcat attcttttcc cggcgttaaa acgcggttta 1687741 cgatatattt ttttgcgttt gtctgcacac actttacttt tttaatggtt tctttttcaa 1687801 gccaattttt atgaatcatg atgaaatctc cttttcttat ctataagctt attgtagctt 1687861 ttttcttttg taaattgcaa tatcggttat tcattgattt tgccttgatt tctattatag 1687921 aatgtttgta tacgcttacg tttgaagcaa ctatcacagc ttatttctgc tattcaatcc 1687981 aggaatcaat gtgctatcac caagaatctc agaacagacc ataaaaaatg actggaggtt 1688041 tgttacggat gagttcttta acgatgcaag tgacgaaaag gctggagaca tttttacagg 1688101 gaacaaagaa gctttatatt gacggaaagt ttgttccgag tgcctcaggg gcaacctttg 1688161 acactccaaa cccggcgacc ggcgaaacct tgatgacgct gtatgaagcc caggctgcgg 1688221 atgtggacaa agctgttaaa gctgcccgga aagcctttga ccaaggtgaa tggagaacaa 1688281 tgtctccagc ttcgagaagc agactgatgt ataagctggc agacttaatg gaagagcata 1688341 aaactgagct tgctcagctt gaaacacttg ataatgggaa accgatcaat gaaacgacta 1688401 atggagatat tccgctggct attgagcata tgcgctatta cgccggctgg tgtacaaaaa 1688461 taacaggaca gacgattccg gtttccggcg cttattttaa ttatacgcgt catgagcctg 1688521 tcggtgtcgt cggccagatc attccatgga atttcccgct cctgatggcg atgtggaaaa 1688581 tgggcgcggc acttgcaaca ggctgtacaa tcgtcctcaa accggctgaa caaacaccgc 1688641 tttcagctct ttatttggca gaattaattg accaagccgg tttccctgcc ggtgtaatca 1688701 acatcatccc aggattcggt gaagatgcgg gagaagcgct gacgaaccac gaagcggttg 1688761 ataaaattgc ctttaccggt tccactgaaa tcggaaagaa aatcatgtcc accgcagcga 1688821 aaagcattaa gcgtgtgaca ttggagctgg gcggaaaatc gcctaatatt cttctgccgg 1688881 atgcgaattt aaaaaaagcc atcccgggcg ctttaaacgg tgtgatgttt aaccagggcc 1688941 aagtctgctg tgcgggctca cgtgtcttca ttcataaaga ccaatatgat gaagttgttg 1689001 atgaaatggc atcctatgct gagtcactcc gccaaggagc gggacttcat aaagatactc 1689061 aaatcgggcc tctcgtaagc aaggaacagc atgagcgcgt tctttcctat attcaaaaag 1689121 gaaaagatga aggagcaaaa gcagtgaccg gcggaagctg tccttttgaa gcaggatatt 1689181 ttgtcgcacc gactgtgttt gcgaatgttg aagacgaaat gaccatcgca aaagaagaaa 1689241 ttttcggacc cgtgctgact gcaattccgt acgaaacagt cgatgaagtt attgaacggg 1689301 caaaccattc agaatatggg cttgcagccg gactatggac agagaacgtc aagcaggctc 1689361 actatatcgc ggaccgactt caagccggaa ccgtttgggt caactgctat aatgtgtttg 1689421 acgcggcgtc tccatttggc ggttataaac agtcaggact cggacgagaa atgggatcat 1689481 atgccttgga taattacaca gaagtcaaaa gtgtatgggt aaaccttgaa gactaacatg 1689541 tatgtttaaa aaactgctgc ctgccagcag tttttttctt tctgtaatgg cagtaaaaga 1689601 cgctgaatat atatgcttct gaaggagttg agcgtgatgg gcacacttca ggagaaagtg 1689661 aggcgttttc aaaagaaaac cattaccgag ttaagagaca ggcaaaatgc tgatggttca 1689721 tggacatttt gctttgaagg accaatcatg acaaattcct tttttatttt gctccttacc 1689781 tcactagatg aaggcgaaaa tgaaaaagaa ctgatatcat cccttgcagc cggcattcat 1689841 gcaaaacagc agccagacgg cacatttatc aactatcccg atgaaacgcg cggaaatcta 1689901 acggctaccg tccaaggata tgtcgggatg ctggcttcag gatgttttca cagaactgag 1689961 ccgcacatga agaaagctga acaatttatc atctcacatg gcggtttgag acatgttcat 1690021 tttatgacaa aatggatgct tgccgcgaac gggctttatc cttggcctgc tttgtattta 1690081 ccattatcac tcatggcgct ccccccaaca ttgccgattc atttctatca gttcagctca 1690141 tatgcccgta ttcattttgc tcctatggct gtaacactca atcagcgatt tgtccttatt 1690201 aaccgcaata tttcatctct tcaccatctc gatccgcaca tgacaaaaaa tcctttcact 1690261 tggcttcggt ctgatgcttt cgaagaaaga gatctcacgt ctattttgtt acattggaaa 1690321 cgcgtttttc atgcaccatt tgcttttcag cagctgggcc tacagacagc taaaacgtat 1690381 atgctggacc ggattgaaaa agatggaaca ttatacagct atgcgagcgc aaccatatat 1690441 atggtttaca gccttctgtc acttggtgtg tcacgctatt ctcctattat caggagggcg 1690501 attaccggca ttaaatcact ggtgactaaa tgcaacggga ttccttatct ggaaaactct 1690561 acttcaactg tttgggatac agctttaata agctatgccc ttcaaaaaaa tggtgtgacc 1690621 gaaacggatg gctctgttac aaaagcagcc gactttttgc tagaacgcca gcataccaaa 1690681 atagcagatt ggtctgtcaa aaatccaaat tcagttcctg gcggctgggg gttttcaaac 1690741 attaatacaa ataaccctga ctgtgacgac actacagccg ttttaaaggc gattccccgc 1690801 aatcattctc ctgcagcatg ggagcggggg gtatcttggc ttttatcgat gcaaaacaat 1690861 gacggcggat tttctgcttt cgaaaaaaat gtgaaccatc cactgatccg ccttctgccg 1690921 cttgaatccg ccgaggacgc tgcagttgac ccttcaaccg ccgacctcac cggacgtgta 1690981 ctgcactttt taggcgagaa agttggcttc acagaaaaac atcaacatat tcaacgcgca 1691041 gtgaagtggc ttttcgaaca tcaggaacaa aatgggtctt ggtacggcag atggggtgtt 1691101 tgctacattt acggcacttg ggctgctctt actggtatgc atgcatgcgg ggttgaccga 1691161 aagcatcccg gtatacaaaa ggctctgcgt tggctcaaat ccatacaaaa tgatgacgga 1691221 agctggggag aatcctgcaa aagcgccgaa atcaaaacat atgtaccgct tcatagagga 1691281 accattgtac aaacggcctg ggctttagac gctttgctca catatgaaaa ttccgaacat 1691341 ccgtctgttg tgaaaggcat gcaatacctt accgacagca gttcgcatag cgccgatagc 1691401 ctcgcgtatc cagcagggat cggattgccg aagcaatttt atattcgcta tcacagttat 1691461 ccatatgtat tctctttgct ggctgtcggg aagtatttag attctattga aaaggagaca 1691521 gcaaatgaaa cgtgaatctt atcaagcgga gatgttcaat tggtgtgaag ccctgaaaga 1691581 tcagattcaa aagcgaggtc agcttgacca gtttgaagat caaatcgaca agatgattga 1691641 ggctctggaa gatgaccaaa caacagaaga agattggtat aaacaggccg ctgcccttta 1691701 tcgggatatt acagaatcag atgatacaag tgaaagacgc gcttatgtcc ctatagggaa 1691761 acacgtgctg ccaaagcttc cttacaaata ctccgcctta gaaccttata tatcacgcga 1691821 tattatgatc cttcatcata caaaacatca tcaaagctat gtcgatggcc tgaacaaagc 1691881 agaatcagag cttaaaaaag cgagagcgac aaagaattat gacttaatca ctcattggga 1691941 aagagagctt gcgttccatg gagcaggcca ttatttgcat agtatttttt ggttttctat 1692001 gcatccaaac ggaaaacggc gtcctacagg ggcattgttc caaatgatag acctttcatt 1692061 tggaagctat tccgctttta aagaacattt tacccaggcc tctaaaaaag tggaaggcgt 1692121 cggctgggcc attctggtct gggcacctcg atcaggacgg ctggagattt taacggcaga 1692181 aaaacaccag ctctttagcc aatgggatgt gatccccctt ttaccgcttg acgtatggga 1692241 gcatgcctac tatttgcaat acaaaaatga ccgggccagc tatgtcgatc actggtggaa 1692301 tgtcgtggat tggcgcgagg ctgaaaaacg ttttgagcag gcaaaagaag tcgtttggaa 1692361 gctctattaa aaaaagcccc ctttcctcgg gggcttcgtg tgttaaaaaa tacctatcac 1692421 atgcaaaaac acgatgatga tggcaacagg agatagatat cgaatgagca gcagccaaac 1692481 cgcaaaccac tttcgtttga gattggaacc gcttttcagc tcgtcaaaca aatcctgttt 1692541 cggtattttt agcggaacaa aaatcgaaat cagtaacgca cctaacggca ttaaaatatt 1692601 gctcacaaga tagtcagccg catcaaaaat agacagatga aatatagtga cgtcacttaa 1692661 gacaccgtat gataatgcag acggcacacc gacaataaaa atagcaatac cgcctaacca 1692721 agcgaatcgt tttctcttat tgatatcgcc tttcgacagt actgcgacca aaatttccag 1692781 cattgaaaaa gcagatgtca atgcagcaaa taaaaataga agtaaaaatg ctaataaaaa 1692841 gataattccg aacggcattt gattaaacac agtcggcaga acgttaaata acagaaccgg 1692901 gccttggtct ggcttgaggc cgaatgaaaa tacagctgga aaaatcgcaa ttccggccat 1692961 tacagcaaca agcatgttca taacagttac agatacagcg gactgtacca gattttcctg 1693021 tttctctaaa taagcgctat acgttaccat gacagataca ccgacactta ataagaaaaa 1693081 ggattgtccc attgcatata aaatggtatt ggcatcaatt gcagttaaat caggcatgag 1693141 gaaaaatttg attccttcca tcgcgccatc aagtgtaacc gaacgcacca ttaaaatgat 1693201 gaataataga aaaagcgccg gcattaatac ttggcttgct ttttcaattc cgctgcttac 1693261 cccttttgca acaactaaaa ttgttaccac cataaagagc agctggcctc ctacagccaa 1693321 ataaggattt gaaatggtac ttgcaaatat cgtatcaaaa ccagatgttt gcgataaacc 1693381 gccagtgaag ccttttataa tataaattaa aatccatccg cctacgacac tgtagaaaga 1693441 tagaagaata aagcacgtca ccatgcctaa ataaccgatc caatgccact tcgttcctgg 1693501 agcaagtgtt ttataggact gaacggcatc tttctgtgtt cttctgccta tgatgaattc 1693561 acctaacaat aaaggcagtc cgattaaaac cgtaaataaa ataaaaataa gtaaaaatgc 1693621 gcctcctccg ctggttccgg caacatatgg gaatttccat atcgcaccaa gcccgatagc 1693681 tgatcctgcc gcggctaaaa taaagccgag cttcgaagac cattgatttg cttccttcac 1693741 cgtatcactc ctatttgatc taaccattat aaaggttcat tgtaagaata tcttcctata 1693801 tagtcaagaa cattttaatt agtttacatc atatatctat agacatctgc caaaaactaa 1693861 tattgaatta ttcagaaaat tatttataat aagagaatgt tatgaaattt gtaagaattt 1693921 ctgctgaagt tcttgataag tgtgttagga gtgtttttat ggacatcatt agaaaaataa 1693981 gccattttgc aggacaaacc tttggcatat gggtcattgt ttttgcagtg ctgggatttt 1694041 ctttcccatc tttatttacg tggatcagtt cttatattac gatttttctc ggcattatca 1694101 tgtttgggat gggccttaca ctgcaagccg atgatttcaa agagctggtc agaaagcctt 1694161 ggcaagttat tattggagta atagctcagt atacgatcat gccgctcgtt gctttcggcc 1694221 tcgcatttgg gcttcatctt ccagctgaaa tcgcagttgg tgttattctt gtcggctgct 1694281 gtcccggggg aactgcatct aatgttatga cattcttagc aaaaggaaat actgcccttt 1694341 ctgttgcggt tacgacaatt tctaccttat tggcacctgt tgtaacaccg ttgttgatta 1694401 tgctgtttgc caaagaatgg cttcctgtct cgccggggtc tttgtttatc tcaatcttac 1694461 aggcggtttt atttccgatc attgcaggtc tgattgtcaa aatgtttttc agaaaacaag 1694521 tggcaaaagc cgtacatgcc cttccgcttg tttctgtcat tggcatcgtt gcgattgtct 1694581 cagctgtcgt cagcggcaat cgggaaaatc tgcttcaatc ggggttgctc attttttcag 1694641 ttgttatcct gcataacggt atcggttatt tactggggtt tctttgtgca aagcttttaa 1694701 aaatggatta cccgtctcaa aaagcgattg caatcgaagt cggcatgcaa aactccgggc 1694761 ttggggctgc acttgccacg gctcatttct caccgctatc tgccgtacca agcgcaatat 1694821 tcagtgtgtg gcataacctt tcaggttcta tgcttgcaac atattggtca aaaaaagtga 1694881 aaaagaagca agctggatcc aaaagcagca atctatcact ttaaatatgc atcaaaaagg 1694941 gtacatcact ttatcgtgat gtaccctttt ttattatcct tctaataaaa gctgttcagg 1695001 atcttccagt aaatttttga ttgtcacgag gaaaccaacc gcttctttac cgtctacaat 1695061 tcggtgatca taagataaag cgatatacat catcggacgg ttttcgaaac gctcttcatc 1695121 aatggctaca gggcgcagct gaatcttatg catgcccagt ataccgactt gcgggctgtt 1695181 taaaattgga gttgacatca atgaaccgaa agtccctccg tttgtaatcg tgaaggagcc 1695241 tccctgaagc tcgctaaggg ttaatttatt gtttcttgct tttttcgcaa gctcgccgat 1695301 ctctttttcg attcctgcaa atgtcaggcg atccgcatcc cgtacaaccg gaacgacaag 1695361 accttcatca gcagcaacag cgattccgat atcgtagaat tttttaacga tcaactcatc 1695421 gccttgaatt tctgcattca acagcggata ttttttcaat gcagccacga ccgctttcgt 1695481 gaagaaagac ataaagccga gcttcacttc attttgctca aaaaattgat ctttgcggcg 1695541 ttttctgaga ttcatgacag ccgtcatgtc cacttcatta aatgtagtca gcatcgctga 1695601 tgtttgctgt acctctacaa ggcgttttgc aatcgtttgt ctgcggcgtg acattttttg 1695661 cacttcaaca ggtttgtcaa agctttgctg tgctttttga gcctgaggct gctgcttttg 1695721 ctgaggagcc ggttttgatg ccggtttttc gtacgcttcg acatcctgct tgcgcactct 1695781 tccaagcgga tctccagttg gaacttgaga caggtcaatt cctttttctc tcgcaagctt 1695841 acgggccgac ggagaagcga tcgttcttga ttttgcttca gattgtgctt cctcgctcac 1695901 ctcttgtgca gctggttcag cctgtttctc ttcttttacg ctttccttgc tttctgtttt 1695961 ctctgtagga gcaggggcag aactttcacc cgcgccttct gaaatcgtac cgataatttc 1696021 tccgacctgg acggtatcac ccgaatcttt caatacctct tgaagtacac ccgattcttc 1696081 tgctgtcaat tcaacattca ctttatccgt ttctagttca agcagatatt caccctgttc 1696141 tacatagtca ccaggctgct ttaaccattg ggctattgtt ccttctgaga ttgattctgc 1696201 taattcaggt accttaattt ccgccatttt ttcatttccc ccttagtttt tgcgagtcaa 1696261 gctatcagat acaatacgtt cctgttcttt tttatgaact gtcggatctc cctctgcagg 1696321 gctggatcgt cttcttcgtc caatatattg aacgcttact ccctctggtg caatctctgt 1696381 caaatacggg ctgatataac cccaagcccc catgttctgc ggctcttcct gcacccaaac 1696441 gatttctttc aggttcggaa gttttgcaaa taattctttg actccttttg ccgggaatgg 1696501 atacagctgt tcgattctcg caatgtgaag ccactcttta ccgtcttcta acttattaaa 1696561 atgatcgcta atgtctatag acactttacc gctggataat acaagtctgg ttactttttc 1696621 atagtcatga gaaagtcccg actgttcata aacaggctgg aagcggcttt cgctgagctc 1696681 ctgcacttcc gacaccgtat ttgggttgcg aagaaggctc ttcggcgtca taatgacgag 1696741 cggtctgatt tcttcacgaa gcagcatttt agcctgtctt cttaaaatat ggaaatactg 1696801 tgccgcgctt gtcaggttgg caaccgtcca gttgttttcc gctgcaagct gcaggaatcg 1696861 ctcaattctt ccgcttgagt gctcaggccc ctgtccctcg taaccgtgcg ggagcagcat 1696921 gactaatccg gatttttggc cccatttcgc gcgtccggca gaaataaatt ggtcaaaata 1696981 cacttgagca gcgttggcaa aatctccgta ctgtgcttcc cacaaaacaa gcgtttccgg 1697041 tgaatgcacg ttatagccgt attcaaaacc gagaaccgat ccttcagaca gcgggctgtt 1697101 atgaacagca aatgatgtgc tgcagtcaga taagtgatga agcggcacaa attctttgcc 1697161 cgtctcactg tcatgaagca caaggtttct ttgggcgaac gttccgcgct cggaatcctg 1697221 tcctgttaaa cgaatcggtg ttccgtcttt caaaattgaa gcaaacgcga gtgattctgc 1697281 caaagaccat tccacttttc tgtcatcatc gaacgccttg gcgcgtcttt ctaaaatgcg 1697341 ctttagcttg ccgaaaacat taaatgactc cggccagttg atcaattcgc cattcagctt 1697401 gcggagcaca tcaaaatcaa tcgaagtgtc cacatctggg aaaccgtttg atacaggctc 1697461 tggaagttca atttcacaag cagtgtgttc ctttttagac ggaactttct gatatgcatc 1697521 ctcaatgcgc ttcgttaccg atttttcgat gttttgaacg acttcctcgg taaccacgcc 1697581 ttcttttacc agcttttcag cgaaaatttg tttgacggtc ggatgctttc tgacagcatc 1697641 atacagcatt ggctgagtgg ttgacggttc atccatttcg ttgtgtccat agcgtctgta 1697701 cccgatcaaa tcaatcagaa aatccttgtt gaatgttttt cggtattcga ccgcaaactt 1697761 aacagctgaa agacaagctt caggatcgtc cgcattcacg tgaacaatcg gaatttcata 1697821 acccttggcc aggtcgctgg catattttgt cgatctggat tcagcgcttt ctgttgtgaa 1697881 tccgatcatg ttattggcga taatatgaat cgcaccgcct acttgatacc cttttaaaga 1697941 gcttaaattc aatgtttcag ctacaattcc ttccccaggg aatgcagcgt ctccatggat 1698001 taaaatggcc agcgattttg tttcatcttg taccgggtat ccgctttgtg ttcgcgtttc 1698061 ctgtgccgct cttgtgctgc cttcaacaat cggattgata aattccaagt ggctcgggtt 1698121 gttcgctaac gtaatgcgcg ctgattttgt ttcagcgtct tgaagctccc gattcgcccc 1698181 caaatggtat ttgacatccc ccgtccatcc gtagctgatt ccaatggatc cctcagacgg 1698241 tacaagatct ttgttcggcg catgctggaa ttcagagaag atgatttcat acggtttgcc 1698301 gagcacatgt gccaagacat tcaggcgtcc cctgtgcgcc atcccgatgt tgacacttgt 1698361 cgtgcctgat ttgacagatt gtgcaataat gtcatcaagc actggaacaa gagcgtccag 1698421 accctcaatg gaaaagcgct tctgcccgac gaatgtgcgg tgcaaaaact gctcaaagcc 1698481 ctctacttct gtcaatcttt ccagcacagc tgacagcttt tcagctgagt tcttctggaa 1698541 cagctcgcca gattcaatct ttcttgtcag ccactcgcgc tctttgaagt catgcacatg 1698601 gtcaaattca aaagagatgg ttcttttata cgtatttcgt aaatactgaa tggcttctaa 1698661 accgttcgaa atgtttttag gagcgtcttt gcagatgaca gacgcaggta ttgcttttat 1698721 ttcctcttct gttagcccgt aatcggataa tggaaaaagt tcgctctttt tctcatcctt 1698781 tctgagcgga ttgacggaag cgttcaaatg gccataggtt cggatatctt ctgcaagtct 1698841 gactgcggat gcgatctttt gaatcagatc ggctgtaaca cgtccctttt cttttgttcc 1698901 cgaggcctct tttatatcgc ttggcggagc accgagctcg tcgaacattt ccttcaaatc 1698961 cgggtcaatg ctgttcggat cctgggtata ctgatcgtaa agctccagcg catagccgag 1699021 gttcggaccg taaaaatctt cccaattcat tcgttgtttc atactatttt gaaacatttg 1699081 aatattaccc ccaacttaaa taatcaagtg attgattcac tatcttgaaa taactttcga 1699141 acgctgtgtc caaaattatg taataaaaac gcttccaacg atattttacc actgtttgca 1699201 atttgattct accttgattg ttcacaaaat agtaaaaaac ctttataaaa aacaaaaaat 1699261 ttaatcattc gaaaaaacaa acgccaaaaa gcataggatt aagggctatc ctatgctttt 1699321 atgaagcagt tttttcagca gcggatacaa aacatccggt agctgatcaa catccgggac 1699381 aaatatactg aattttccgt acatatcctg gatcgtcttc atttgcgatt cttctatttc 1699441 tgagttggag agaaaaacat ttatcacttc tattcctctt tttcgggctt cgataaccgc 1699501 ctcacttgta tcaacgatcc cattttgttc gtagccaaat gcggccggct ctccatctga 1699561 gaaaacaatt aagaactttt gcgcctcgct gcgatgcagc atttttttcg tcatctgcct 1699621 aattgcgtac ccgtcacggt tatcttcttc tggctcaagc tgcataatgg ccggtccaga 1699681 atcttgtctt aatgatgatt ggaagggaat aaccgtattg aaatagtttg gctggctttt 1699741 ttcggttgca tcatttgtgt cctcccaaaa accgacaatc tgatgcggaa ccgctaccga 1699801 tttcaacgct tcgtgaaaca gcacgattcc tcgttttgtt tcgtccattt tgtcgaacat 1699861 gctggcggaa caatcgacca gcaatgtaaa aactgcgtcg atttctgaag atggttcttg 1699921 ctttttgtag aacaggcgcg gatttcgctc agtgaagtaa cgaagaagct tattgttcag 1699981 tctcccggca tgaaggtctg ttctcggcaa tgttttttta tgctccagcg ttttttgaat 1700041 catttgtttc aaacgctttt gatacgattc aatcgttttt gcctgctgtt tataagaaag 1700101 ctcttcttca ctggttgccg gctgcggttc tttataaatt ggaaatgcat atttattttc 1700161 tttgccgtca gccatacccg ctccgttcgg ctggtctttt tgggactcca gcgcttccag 1700221 cttggaatag tctttccgtt tcgtttgtct ggctgatcct tgaacagagc caagggcctg 1700281 atctccatcg tcgccttccc ttgaagcatc ttttcctaaa tctgattttg cgccgtgttc 1700341 aatatcaaat tgaaggaagc ttttagacgg tgcttctgtt tcccggtgcc atgtcggcat 1700401 ttcttcttca tggatatcct catcaccgtc tgattgtttt ggaagcgtga tgtcatcact 1700461 cagcttcggc gcttttttct cttcttcaaa taacggctgt tctgcagctt ttgcgtaatc 1700521 aagctcaggc aaaaagaagt aggtgttcaa catgtcttta tcgagtacct cttcaagtcc 1700581 gtccatgagg tcctcaacaa ttttcagaac ctgccgtgtc gaatctgctt catacacacg 1700641 caagagctgc tgctcaataa acgggcgcat cagatcgata tcttcacgca tggatggaag 1700701 ggtctcgagc ggcgattccg ctgtgagctt gaaatagatc gcgcaaaaga gcgcatcggt 1700761 aaaaatgctt cgttccaaat ttaaggtcag ctgggttgag aaatgttttc tgtacatgtc 1700821 ttttcgcttc gcaaatacat gtttcgtacc cgggcgctca cgtttgatgc attcttcgat 1700881 cctaatgtct tcaagcagca taaagagctg cttggcaaaa cttttaaacg taagatggcg 1700941 atggatatca ttcaaaaagt tcgcaaactc atgcagcgag ctatatcttg ttccgactga 1701001 acgcaggtag acgtcgcttt tcagacccgc ttccatgtcc tcagctgccc tgtctttcca 1701061 aaagtggctc atatagattt tcttttcaaa tggattgtaa taggactgaa cgccatactc 1701121 cacttctacc gcttcactct tggtgagtgt tttggccaaa tcagtcagca tcataaataa 1701181 aaatgaatca atcgtgctgt cgttaaattt gataaatttc atcgcagccc cctcattcaa 1701241 acagagtttc tgcaatattt cggacagccg ctttttcccg atcatcatca agcttttcta 1701301 caattccccg ctcaatggca cgacgcggcg gaatataagc agctaaatca catgtatcga 1701361 ttaaagctct gatggatgcc gcttcttcag acacctgtcc gttattggcc tgaacgatca 1701421 agtcagagga aagcgtgata aatctgtcaa tcaatttctc gtctttcaag gctgactgag 1701481 acatgagcac ttgtttcagc agctcgcctt taatataagg cacatcaatg atgacaaaac 1701541 ggtttttcaa cgcttcattc agaggaacag ttccgacata gccttcattg atggctgcaa 1701601 tgactccgaa accgctttta gcccgtatga cctcgcctgt aaacggattt gtcatcattt 1701661 ttctgtaatc taatacaccg tttagaatag gcagtgtttc cggcttcgcc atattgattt 1701721 catctatata aagaaaatgg ccttccttca ttgcctttgt aacaggtcct gaaacaaact 1701781 cgattgttgc ctggccagat tgattttcaa tcgttttata accgaccaat gcctcagcgt 1701841 ccaagtcgac tgaacagttg acgctgtgca tcggtttatg aaaatagctg gacaatgttt 1701901 ctgccagctt tgtttttcct gaacctgtag gccctttcag caggacattt ttccccatgg 1701961 ctaatgcaat aatggcgtca aataaaatgg cttcatcctc cgcctcatag cctgatgttc 1702021 ctataagcga ttgaaactct ggggaaatag gctgctcttt atatgataaa agcttttgtt 1702081 gtatatcttc cggcaatgtt aagtgctgta gttgagttgt catagacaga ttccctttcc 1702141 tattcatatt ccattaacga gtatactaaa aaagcccctg tatgctcaat acaaaagggc 1702201 ctggatgata ttactgcttc tcgttatttc ccaaaagggc tccgcagaca atacgcgcac 1702261 cggaattgcc gcttgggttt gtcagataat cgtccgcttg ttcatgaata ataaatgcac 1702321 ttccgtcctc gtcgagaata tttagtttac ttcctttttt cagtgaagtg tcaggcgcat 1702381 tcattatgac atctaccttt ccatcagcac cgacttcaag gttcggcaga tctccggcat 1702441 gatgccccat cggattatta aagccgtgtt ctttgttcag tggattaaag ggaccgcccg 1702501 ctgattcaaa atccggcctg acacaagaac ctttctcata aatatgaaaa ccgagagaag 1702561 cacctggacg caggctgttt gcggaaatat gaatatcgag gccttcatca tctgattctt 1702621 tgatctctat aaaaccgact gctttccctt cacgattgac cagctggaca tgatgaccaa 1702681 acgctgacgt ttcaaccact tttttttccg gcacccggtt aggagggtct ggaggttttt 1702741 tttgtccgca tccggcaact cccagtgccg tcagcatcat caacagcaag agacggtgca 1702801 tactgtctcc cccttgtttt ttctaacagt gtggtcaatc attgtctggt ataaacaaaa 1702861 aagcctataa aaggcttttt gtcatactca tttttaaaaa taacttcttg cgcccaagta 1702921 ccgctgtttc caatacgaat tgctgagatt ggaaatgtcg acgcccgatg agcttgcatg 1702981 aataaaatca ccgccgccta gataaatccc catgtgagac gggccggatt tatatgtggt 1703041 aaagaagaca aagtctccta ctgacggctg gctgactttc tgcatgacat tccaataccc 1703101 tgccgtactc aatcttgata tagatgatac attattaatg aggtaataaa tgaagccgct 1703161 gcaatcaaaa ccggcaggcg tgtttccgcc ccatcggtaa ggcactccga catatttttt 1703221 cgcttccgtt atcattctgt caatcttcga acctatttga atgtttgacc ctgagttatc 1703281 ttttggcttt gttggctttg tcggatttga aggattagat tttgatgctc ccgaaatagt 1703341 cagaacctgc ccgatttgca acacatccga tgataaattg tttttatcac ggatgctttg 1703401 gacagtgact ccgagccgat ttgcaatttt ccacagcgaa tcgcctgctt ttaccttgta 1703461 cgtcgttgtt tttgagggat tggagtttga cggctttttg gaaccgctgt ttccgttctt 1703521 aggtgaactg cttcctttta ttttgagcac ctgtttagga taaagtgtat ctgatgttaa 1703581 gccatttaag gtttttaatt cggctacagt catatttaag ctgtttgcga ttttccacag 1703641 tgagtcacca agcttgaccg tatatgtact ttttgaagaa cctgaagaat tggaaccgct 1703701 gtttttcttt gatccatttg atccgcttga actgcttgtc cctttgatct taagcttttg 1703761 ccccggacga atcaggtcac tgctcaggct gtttaagctt ttaagctcag aaacactcat 1703821 tttatgattt ttagcaatca tccataggga atcaccatat gcaactgtgt atgttgatgt 1703881 tttgcttgaa ttagatgggg atgtcgtgct ttttttgctg ctttcaggaa ccttaagact 1703941 ttgtccgaca taaagcaccg ttgatttcaa tttgttttcg gatttcagag ctgatattgt 1704001 cgtatcatac tggcgggaaa gtttccaaag agagtcaccg ctttttactt ttatcgtttt 1704061 tgcttccgcg ggtgctgcgg ccatcgacga cccaacaact gcagaaacag ccaagccggc 1704121 tacaatcttc tttttcattc attcaacctc ctaaactgtt tttttgcaaa aacagctagt 1704181 attttgtttc caaaaatggc acacaactgt tttatcgtca atttttcagc aagttaaacc 1704241 cttttcaaac atttggcgca gcattttcag catcgttcga cctttaaacc ttcaaataaa 1704301 catctaacat tttacataag cacgatatgt ttttcgaaag tctaaggaac tatttaagcg 1704361 agggtaaaaa tgatggtttt ctattgatga acgaagcagt ttctcctcct ttcttgtcta 1704421 tttttctaat caattctcta tcggcgtgtc aaatcccttc ctctgcattc ttatgaaatg 1704481 gcaaaaagcc tgttctttcg ataagaacag gcttttacac tatgcatttg ctgattgagt 1704541 tttttgtttt acagcttcaa gaatgctgtc ggctgctttt ttagagccgc ctgccgcttt 1704601 cagtgattgt ccaatttctt ttgccttttc agcatacgaa cgattattca ttacttcttg 1704661 tatcgtctct ttcagtaggc tttcagacaa ttcttccttt ttaattactt ttcctgcgcc 1704721 gactttttct acctgatctg cgacaacaaa ttggtcgcct cccatcggaa tgacaacgag 1704781 cggggtttca aaatacaaac cttcacttgt gctgttcatt ccgccgtggg tcacaaataa 1704841 gctggctctt ttcaagatct caagctgagg gacatacggg cgtacaatga aattctccgg 1704901 aatgtcgttt aactcacttg ttttaatatg cttgccgatg gaaagcacaa ctttaccgtc 1704961 aaagtcctta cacacttcaa ggcattgatt aaaaaactgc ttttgattat taaaaatggt 1705021 tcccattgaa ataaacagca cgttttcatt gtcaatctga tcaaatggga aatcattgtt 1705081 tccggctctt tctgtaatgg aaggaccgac aaatacatat cgctcgccaa attgctcagc 1705141 cagtggctga aatccccttg atgtaaagac gattgtcaag tcaccatcag ctaaaaaaac 1705201 atcaaatggc ttcttgatct ctgcttgaaa atcagcattt aacgtttctg caagctgctg 1705261 gtatgattca taatgaggcg aatcttcaag tgatcctttc atgtacgctc ccatcatttc 1705321 cttcgcaaat tcctcattca tcgcaaaggt tgtacacaat gaaaatcttg gcagcttcag 1705381 catgttggca atgactttac ccgcgagaag atggtgatca tatatgacat aatcatacga 1705441 ttcatgtttg acttcctcat aaatatgagt cgcgatatcc ttacaggctt tcaaaaaagc 1705501 gcagagcatt tctgtgaaat ctctttcttc atcgccggtt gcgtttttcc cgaagtaatc 1705561 tcctctgaaa tcatgatact cacgaaactc tatatcaaga gctgtgattt tttctttata 1705621 ttccttcact gcgtagtacg taatgttttc tccccgggat ttcagctcct tcatcacacc 1705681 gatagaggga ttaatatgcc cttcaccggg gaaaccgatc attaatacat tagccatgcg 1705741 gcagcaccct tcctttgaga atttatgtaa tattttatac ggtactataa atgcataaac 1705801 aggtaaagta tttcacttaa ttaatattca tcatatataa cttttctacc agtttatatt 1705861 ccctgtcttc aagacaaaaa gcattcagct tgaagcgaat gctttaataa agatgcgaat 1705921 tcagtcattt tgtctcatga taggattctt aatcaggccc tttttattat ttttacgttc 1705981 ttggtgaaat taacggatat aatacaccgt ctttggcaaa cgacatcttc cctgtttcct 1706041 ctgaaaccac gagcaccagt gcatccgtat agcccgacat accaagagcc gcccggtgcc 1706101 gggttcccaa atggatatcc acttccttcg tcgtcagcgg gagcacattg gctgctgaca 1706161 cgagtttgtt ttccctcact aataaagcgc cgtcatgaag agggtttccg ggaaaaaaga 1706221 tgctttcaat taatgaagag ctgatctcgg cgtgtaggga ggtgcctttt tgaataaaac 1706281 gttcaaccgg gtctgctctt tcaatcacaa ttaaagctcc atgcttatgt tccgataagg 1706341 ctttaatcgc cttggccagc tcaataaatg ccggcgtaaa ttcctcaatg tatgattgca 1706401 aataaaagga ggatgcaatc ccctgcatgt cctgaaaaac gtgccccaaa tcatctaatt 1706461 cacaaaggag acactggtct ttttcgtgaa gcgttttcaa gattagagat gcatcaccta 1706521 atatttgctc taagtacacc tgtattttcc ccttgaacgc attttctgat atctgctcat 1706581 agcgcatagc cttcatctcc tgtttaaatt tccaactttt cacgaatgct tatcttattg 1706641 atgcacattc tattggtaaa ggagggatgt aaagaatgga aatcgaaaga atcattcagt 1706701 atatttgcac ctttttaggc gtgatttcgc tttcttttat ttatgcccaa atgtttagaa 1706761 aaacgaaacc gacaaaaaaa gaataggccc ggcgttcatt gctttttata cataaaatgt 1706821 tataatttct ctcgttatga aaaagaaacg gagatcaatg tatgaaagaa actcaaaacg 1706881 cccgggaaaa aatcaaacag ctcttgcaca ttttaatacc gatattcatt acccaagcgg 1706941 ggctttctct gatcactttt ctagatactg tgatgtcagg gaaagtcagc cccgctgatt 1707001 tagctggtgt cgccattggc tcaagccttt ggacccctgt ttacacagga cttgcaggta 1707061 tattaatggc ggtcaccccg attgtcgctc agttattagg tgcagagaaa aaacagaaga 1707121 ttccctttac tgttttacaa gctgtatacg tggccgcgct tcttagcatc gccgttttag 1707181 tgattggata tgctgcagtt gaccttattc ttggccgatt gaaccttgat attcacgtgc 1707241 atcagattgc taaacacttt ttaggctttt tatcactggg aattttccct ttatttgttt 1707301 acaccgtgtt gagatcattc atcgactcat taggaaaaac gagagtcacc atgatgatta 1707361 cactcagttc tcttccaatc aattttgtat tgaattatgt atttatcttc gggaagttcg 1707421 gaatgccggc acttggaggt gtaggcgcgg gactggcatc cgcgttaact tactggtgta 1707481 tatgcatcat cagttttttc attattcata aaaacgcacc gttttctgaa tacgggattt 1707541 ttcttaccat gtataagttc tcttggaaag catgcaaaaa tttgctcaaa atcgggctgc 1707601 ctattgggtt cgccgtgttt tttgaaacga gcattttcgc agctgtcacg cttctcatga 1707661 gccattttca tacagtgacc atcgcgtccc accaggcagc catgaatttt gcgtctcttt 1707721 tatatatgct gccgcttagc gtgtccatgg ctctaacaat tgttgtcgga tttgaagcgg 1707781 gtgcagcccg ttttaaggat gcacgctcat atagcttaat cggcatcatg atggcgatcg 1707841 gcttttcttt gttcactgcc gcctgtatcc ttttattcag agagcaaatt gcgggcatgt 1707901 acacttctga ccccgatgtg ctccggctga cacagcactt tttaatttat gcgctatttt 1707961 ttcagctttc cgatgctgtt gccgcaccga tccagggagc actcagaggg tacaaagatg 1708021 tgaactatac gcttgcggcc gcttttgtct cttactgggt cattggcctt ccggtcggtt 1708081 atatggtcgg tacgtttaca agcctcggtg cattcggcta ttggattgga ttaatagcgg 1708141 gactcgccgc cggagcagtt gggctgtttt tcaggctggc aaaactgcaa aaacgttatt 1708201 cgcaaaaaca acacatttaa aagaggtgat caatcatggc aaaaaacaaa aaattattcg 1708261 agtatctttc ccagcatgcg gaaaccatca gttcaacatg gtatgaaaca atcgaggaga 1708321 ctgatcccaa ttccatttat gcctcaacag accctgttgt cattcacaat ttaaagagcc 1708381 agaatcttgc ctttaactat aaaataaacc gtatttttat agatgatgag gacgtatact 1708441 tgcctatact gaaagaatgg gcctttgaag tcacacagga tcaagagcat ttaaaaactc 1708501 ctatccacta tattattcgg gagtttgtca gagtgagaga tttatatgtt tcttatgtga 1708561 aagaatttgt ccatctcaat cagaatactg tgaaaagcga agaagccgaa gacctgtatc 1708621 acgcccttat aaaagcgttt gatcttgtga ttcatatttt tatagaagaa atgtacaaaa 1708681 acacaagcct tcagcttcag gcccaaaaag atatgattac tgaattgagc gctccggtca 1708741 tcgtgctgtt tcacagcgtc ggactgctgc ctttaatcgg agatattgat acagtccgcg 1708801 ccaagctgat tatggaaaac acactgcatc aatgtgcgaa aaaaaaggtg acacaactgt 1708861 atattgattt gtcaggagta gctgtgattg atacgatggt tgcccatcag ctgttcagtc 1708921 tgattgaggc gcttcgttta atcggtgttt cttcaacttt gtctggaatc cgtccggaaa 1708981 tcgcgcaaac agcggttcag ctaggtttgt ctttcgaagg tatttccttg agatccactc 1709041 tcgcttcagc tattgcatcg gacttaaaat taaaaaaggt ataaggctta aggccttata 1709101 cctttttgat taatcattcc attgatacgt ccaatatatt tcttcttcaa accatgttgc 1709161 cataacaggt tcattatttt tcaatttctc ttcaagctct ctgagcatgc cttctgtttg 1709221 tgtgcggtga gctcttaacg cattcatttt aatatcagct acttctttga tatcaagtac 1709281 gacatcagct tcgccgagaa cctcttctct gttgcgggta atggccatgc agattgtacg 1709341 cggacggtct tctttctttt tgcggtataa tgcacggata accgcttccc cgcatgcatc 1709401 atggtcaggg tgcacaccgt gtccgggata aaatgtgaca attaaacttg gttttacatc 1709461 atctatgatc tcttccatga tatcagctaa atactcatcg tcttcaaatt cgagcgtttt 1709521 gtcacggagt ccaagcatcc gaaggtcatt gatatccatt tctttgcaag cgttgatgag 1709581 ctcttgtttt cttagcagcg gcaacgtttc ccgattcgcg aaaaatggat cgcccatatt 1709641 tctgcccatt tcacctaaag tggcgcaggc atacgtaacg ggaatgtctt tttttctgtt 1709701 taaggcaatg aggcctgcca ctccatatga ttcatcatca gggtgaggca ggattactag 1709761 tacatgttct ttcattatta ttcacccttt tctttaaact gtgaacggtt tttcgctgat 1709821 ttgcagagaa atagccagtt taccgcccgg caggtgtccc gccattaata aacggttttc 1709881 ttcatctacc gtgtattcag tcaagccttc agcataaatc cagccttctt ctgttttcaa 1709941 gccaacgcgg taaggcccgt tgcctttgat ttttgcctga tgataagtga cttttgcatt 1710001 gcgaatatac gcaacaaccg tcatgttctt ttcatttaag tgcgctgaat aagaacctgt 1710061 ggtggtttct aaatggatat atacagggcg gtccgcatat cgttctaaag atgcttgcac 1710121 atcttctttt atgatcgctt tcatgattgc tcccctcttt cttcttttaa atactctgca 1710181 cgttctgtat gtaatttgac cagctgatat ttcacagccg gttcgagctg tgaattcaca 1710241 atgcgctgaa tcgcggcaaa atatttttcc agcatcggtt ttcggagtct tggatgtgtt 1710301 cgtttatcca agagctcaag atcaatcgcc tctgctaccg cttctgcgtc atcatgtgcg 1710361 agagatcggt tattccaaag tgaagcatag gctttcacta tctctttatc attgtccatc 1710421 gtcttgctcc tttatgtctt acatacatga aatgattata cataatatat gcatcagctg 1710481 aaaagccaaa ggcctcaatg gctttttgac gcccgtttcc acttcacttg tgaaaacgta 1710541 aacaagagca gcgcagccca tatacagctg aatgtaaaag ccttcgagct tgaaaatggc 1710601 tcatggtaaa caaacagccc gatcagcagg gtaatggtcg gcgcaatata ttgtaagata 1710661 ccgacttgat acagtggcag ccgtttcgct ccttccgcaa acaataagag cggcaaagcc 1710721 gtaaacacac cggccaaaaa gagaagcagc cacgtccctc cgctttctgc acccgctggc 1710781 tgaacatgtc cgctgaacag caaatacccc aatgcaatgg gcataatcat gaatgtttcc 1710841 agcgttaaac cgatggcgct cggcaggctt gttctttttt tgcttaaccc gtacagccca 1710901 aagctgaatg cgagcagaag cgcaacataa ggaatggagc cgtattggaa cgccgagatg 1710961 atgacaccgg ctgccgcaat cgaaacggcc actaattgca ggcgattcag tttttccttt 1711021 aaaaataaaa tcccaaggag cactgataca agcggattaa tgtaatagcc aagactagcc 1711081 tcaagcaaaa agccatggtt gacagcccat atgtatacaa accagttgat cgaaatcagg 1711141 atagaagcaa gaaataaaga gaggatccct ccgttctttt tcagagagcg caactcctgc 1711201 catcctattt tccattgccg caagaaaaaa agtacgatac acataaaaac aaaagaccat 1711261 ataatacgat gagccaaaat atcaagagcc ggcagctgtt cgagaagctt ccaatagagc 1711321 ggaaacaggc cccacatgat aaatgaaacg gctgtgtaaa taacgccttt ttttgtttct 1711381 gcatgttgca ttgatatccc tgcctttctt tagagcatct tatattatat cacgtgaaag 1711441 atctggtggg catatactat tttgtccgtg aagaaaggat gtgaagacaa tgtttgagtg 1711501 gaacaagtac tttcctttcc acaatcaatt ttctaaagaa gcattaaaaa aagctgatcc 1711561 gaaagaagtt gaaacgtatg tcaatcgtgt gatggaaagt gtgttcggca gtgattatgc 1711621 ggctcaattt cctttccgcg atcctctccc ccaaaaagaa catcccgcca aacctgatgc 1711681 aaaacctgat gtcaaacctg atattgatat attcgaaaca gcagaccatg tgtttgtaaa 1711741 ggtgccaatc agcgaagaat ggctggaaca agtgagaatc aaacacacat ctcacgaatt 1711801 atggttggaa aacctcccaa gagcagatca tccgaaaaaa gtaaaccttc cttgtttagt 1711861 caaacgcaaa ggaacaaaag ccgtctataa ggatggcctt ctggaagtca tgtttcaaaa 1711921 gcagcaagac tacaatatgt ccgaggtaga aatcatccga taaaaaacgg cctgcaatcg 1711981 atgcaggccg ttttttatta atagaagccg ggatatcccc cgtatggcac gccggcacca 1712041 aaaccgtacg gtccgcctcc atatccataa gggccaggag gataggcata gggacgagaa 1712101 tagttaaaca gcgcactccc gagaaaaccg cctaataaac cgccgactag aggagcgcca 1712161 aacaaaaaag gactacgcgc cggatatccg gctggacctg ggattccgcg taaatacgaa 1712221 tgatgagggt acatgatttt ttcctccttt atgtctgcct atacgtaaag tattcagcaa 1712281 ggaagaaaaa cgattgggct acggactgtc tatgattgtt acatcacaag ccctgccaat 1712341 aacacacagc cgagccctgt aaccgaaaga actgttgtaa gcagcgtcca ggtttgaaat 1712401 gtttctttca tgctcaagcc gaaaaattcc tttaccatcc aaaatcctgc atcatttaca 1712461 tgacacgcaa tgacactgcc ggctcctgtt gcaagcacca ttaacgcagg gtttacactg 1712521 ccagcctcca taagcggagc tgccattccc gctgtggtaa gcgcagccac ggtagcagag 1712581 cctagacaca gacgcagaac cgcggcgatg gtccatgcaa cgaatagcgg cgacatgttt 1712641 gtttgacgga aaaaatcagc gacataatcg ccgactccgc cgtcaatcag cacctgttta 1712701 aacgctcctc cccctcctat gatgagcagc atcatcgcaa tttgcgaaat tgattctgaa 1712761 atagatctgc cgatttcctg catagatatt ttacgggcat atcccatcgt atagagtgca 1712821 agcaacagcg aaatgagcat tgccgttccc ggagtgccga taaattctat aatgtctttt 1712881 ccttttgaat gttcactcaa taataaagaa aaaattgttg ccattgccat aaagataacc 1712941 gggaataaag acgtgacagc actgatcgca aagcccggtg tttcatccag ctgaaattct 1713001 ttccttggtc ctaaccccga taggtttcca tgcttttgat acgcaccagg aaaccgtttc 1713061 atcgcaaatt tattaaataa aggcccggca atcacagttg tcggaacagc gatgatgatt 1713121 ccaaaaagca gcacctggcc aatatgggca ccatatgcaa ctgagatagc agttggagca 1713181 ggatgcgggg gcaaaaatcc gtgagtaaca tttaaggcgg cggccatcgg gattcccaga 1713241 tacagaaaag gcatttttaa ttctttagca atcgcgtaaa caatcggtat caacagaaca 1713301 agaccgactt caaaaaatag ggcaatcccg atgataaaag aggcaaccac aaccgccgcc 1713361 tgtattcgtt tcctcccgaa tttgtcaatc agcgtaatgg cgatccggta gccgccccca 1713421 gcatctgaga caagcctccc aagcatcgcg ccaagtccaa acactaaagc taaatgcccc 1713481 agctgcccgc caattccagt ctcaattgaa agaacaattt tattgatatc cattccaagt 1713541 ccgatggcta ctaaaaatga aacgacaatc agtgagacaa aggtatttaa ttttacttta 1713601 ataatgagaa ataacagaat cagcactccg acagctacaa ttaaaatcgg catggtaccc 1713661 ctccaaaagt gttttatatg attctcgcga caatgttttg gcgcttttca tgcctagatg 1713721 aacagaaagc gctttcatta ataactaaaa acgtcttggt tatatgattg ttatcttttg 1713781 atcaactaat atgttcatac taatctccta atcaatgact gtcaatcgtt tttatgagct 1713841 tgtctcgatt acctaccgcc taacccaatg atttattagt tatatgttga ttaacttttg 1713901 gttatatgtt atgtttttta aagttgactg ccaatcatta tatctctcca ttgtctggaa 1713961 gcaaatgaga caatatgaga acagacggat aacaacttca taagaggagg agtacacatg 1714021 ccattattgc gttttgatgt aattgagggc cgtgatgaaa aatcgctgca attgttatta 1714081 gatactgctc accaagcgat ggttgaagca tttggtgttc cggaaagaga ccgttatcaa 1714141 attgtccatc agcatcccgc aaacgagctt ataatccagg atgcgggatt agggtttcag 1714201 agaaccaagg atatggtcat cattagcatg acaagcaaag caagaaccga aagccaaaag 1714261 gaaaaattgt atgctctgct tgctgaaagg ctagaaaaaa aatgcgaaat ttcccctgac 1714321 gacctcatgg tatctattac tgagaatggt gacgcagact ggagtttcgg tctcggtgag 1714381 gcgcaatttt tgaatggaaa actataagat ttcgtctccc cacaaaaaaa agaagagaga 1714441 gctccaaaga agctctctct tttttcataa atgcggaagt catcagtata gaagcatcca 1714501 gcaatacgaa aaacctggat ctccttttat atccggttta aatgccaatt ggaagctgac 1714561 tgggttttgg ctgaaaatat aaaattttgc tgatttgcat aataagatac atcataatcc 1714621 ccatttacaa taggttggat gttatagctt attgatcatt tcctatttta tatatcccct 1714681 tcatatgcac atgacatttt tgccaatccg gaaatatcag tctgacaaat ataaaaagtc 1714741 atgtaaacgg gtgtgaaccg tacttacatg actcaccatg gaaacaaagg ctctttttca 1714801 ggtgccgctt tccttatttc tcttcttcac acactgtgtc accaggctcg caaaattgat 1714861 cggcccatgc ctgcatttct tgaaatacag cttgaagcgc tgttcctttt tcagtcagcg 1714921 tgtagatgac tttgaccggc gtttcaggga gaacctgccg ttcgacaatc tcgttttgtt 1714981 caagctcctt caagcgctct gccaacattt tttggctgat catcggtatt gtttccgtta 1715041 tctctttaaa ccgtttcggc ccatccatta gcacatggat gatcagaccg ttccatcgtt 1715101 ttcccagcaa tgagaatgcg gattccattt tagggcacat cgtatttccc ataagtcttc 1715161 atcccttcat ctattgattg acatgtattc aatgatccat tacaataatc tttcaagtta 1715221 catttagtaa gcttctaact tttctattat cataccacgt ttatccgaag gaggaaacac 1715281 tatgacgaat actctggatg ttttaaaagc acgtgcatct gtaaaggaat atgatacaaa 1715341 tgccccgatc tctaaggagg agctgactga gctattagac cttgccacta aagcgccttc 1715401 tgcttggaac cttcagcatt ggcattttac agtattccac agcgatgaat caaaagcgga 1715461 gcttcttcct gtagcgtata atcaaaaaca aatcgttgag tcttctgctg ttgttgccat 1715521 tttaggcgat ttaaaggcaa atgaaaacgg tgaagaagtt tatgctgaat tagcaagcca 1715581 aggctatatt acggatgaaa tcaaacaaac attgctcggc caaatcaacg gtgcttacca 1715641 aagcgagcaa ttcgcacgtg attccgcttt cttaaatgct tctttagctg ctatgcagct 1715701 tatgattgcc gcaaaagcaa aaggttatga cacttgcgca atcggcggat ttaacaaaga 1715761 gcagttccaa aagcaatttg atatcagtga gcgctatgtt ccggttatgc ttatttcaat 1715821 cggcaaagca gtgaagcctg cgcatcaaag caaccgtctg ccgctttcaa aagtatcaac 1715881 ttggctgtaa ggatatgaaa aaccttagtc cgaaatccgg actaaggttt ttttatacaa 1715941 tcgcctcttt gtaccattca cgagcctgtt cagcttcatg ctgagtcagc tgatggcccc 1716001 cgtcctgcca gtaaacggag gctgatgccc cgctgtcacg caaatagcgg taaagctctt 1716061 ctgattcttc cttcgtgcaa agaggatcgt atttcccggc accgataaaa acagggagcc 1716121 ccgccatatc aggcagctcg ataccccgaa tcggaaccat tggatgatgc agaatagccc 1716181 cttttaacac atctttataa tgaaaaagca ggcttgccgc aatgtttgcg ccgtttgaat 1716241 aaccgactgc aatcactcgg ccgcgattaa actgatgcgt ttctgcagcc tcgtcgataa 1716301 aatctttcaa ttctcttgtc cgcaccacaa gatccttttc atcaaaaact ccttcactca 1716361 gacgtttgaa aaatcgcggc attccatttt caagcaccga tcctctgaca ccaagcaaat 1716421 gggcatcagg gtctataaac cgccccaatg aaagcagatc gtgttcatta ccacccgtgc 1716481 catgcaacag caaaagtacg ttgtcagatg ttcctttctc ataaatatgc ttcattataa 1716541 attccccctt ttaaagttca ggtaaaatgt ctgtaatttg ttgtctatgt ttctccagcc 1716601 attcaggcag ttttaaggaa gtccctagct cagcaaacgt ttcatctgtc ataaagcccg 1716661 gttcatctgt ggcaatttca aataagatac cgcctttctc cctaaaataa actgatgtaa 1716721 agtattccct gtcgagaatt tctgacgaag gcagatggtt ttcagcaata atcggcagcc 1716781 atttcgcctg ttcctttttc ttagtccgaa acgctacatg gtgtaccgta ccatatcctc 1716841 cgactcctct tttttcagga tgtaaatgga catcaatgac accgccgacc gccgctgaag 1716901 atgccagtct gacaatctgg tcttcttcgg ccactttggt gtatccaaag ctttccgtta 1716961 acaattgtat ggtcgcctgc gggtcgtagg aatatagcag cacacctttc attcccgtaa 1717021 ttgcttcatt tgttgtgatc ccgtcaggcg tccactcgct tttgccgctt ttcgcatcct 1717081 ccatgatcgc cagcggaagg tcttctgtat catcaaaaat aagacctttt tcaccaaaca 1717141 acgttttttc ctctaggctc agcccgcttt tctcaagacg ttccttccaa aaagacaggg 1717201 agcctgaggg aactgaaaag tacacccggc ccgcttggcc ttttcctacc gttccctgtc 1717261 cgcttccttg gaacggaaaa aaggtcatta ttgtaccggg atctccgttt tgattcccaa 1717321 agtaaaaatg atacgttccg ggatcatcaa agtttactgt ttttttaacg agcctgagcc 1717381 caagcacttc tgtataaaat cgcaagtttt cttgcggatc tctggcgaat gctgtgacat 1717441 ggtgcaatcc ttctgttttc attttctcac tcctatttat ctcgatttca agatatttat 1717501 tattttaaac ctttattgaa aaggatgcaa accatgtgtt ttgattaaat aattgaaaaa 1717561 atcatttttt tctaataatt atcttgtgat cttttcttac aactgctatt atagtgagca 1717621 ttatcatgtt tcaggaggaa agtaaatggt taaaaaagca cttattgtta ttctcattct 1717681 tttgccattc gttcagctcg cgcttttgcc gcttgtgaat cgaatagaac cgattatgtt 1717741 cggcctgccg tttttccact tttggctgct gctgtggatt attgttacgc cgttatgctc 1717801 gtttggcatt tatcagatgc aaaaaaaaga tggaggactt gaataatgca agggaatctg 1717861 actgcacttc tcattactgc tattattgtt ttaaccgttg tctgtatcgg ctttctcgcc 1717921 ggaagagaca aatcctcacg tacttctgtg gaagaatggt ctgtcggcgg cagacgcttc 1717981 ggcggtcttc tcgtctggtt tttagtaggc gctgaccttt atacggccta tactttctta 1718041 gggttgacca gtactgcttt tacaggcgga agtgttgcat ttttcgccat tccttattct 1718101 gtgttggcct actttatcgc ctacttcttc ttgccaaaac tttggaaagt tgcgaaaatt 1718161 cataaattaa caacactcgc ggattatgcc cgggaacgtt ttaacagtaa gcttttggca 1718221 agcctcgttg ccatcgttgg ggtactcatg cttattccgt acatatgcct tcagctgagc 1718281 ggcattcaag acacgcttca ggttgccggc actggctata ttaacgtaaa attcgttgtg 1718341 atcatttcat ttattcttgt tgctctttac acattcttca gcgggattaa agggcccaca 1718401 tatacagcca tcattaagga cattttagta tgggtcatta tgctgtttat ggtggtgtcc 1718461 ctccctctca ttcattttaa cggctggacg ccaatgattg acacgttagt gaaggaagcg 1718521 ccgcaaatgc tgacgatacc gtcagaaggg ccaaaaggca ttccttggtt tatcacagca 1718581 tctattgttt ccgctctggc actttttatg tgggcacatg ccgctacagg tgttttcacg 1718641 gcgaaaagcg ctgatgcagt aagaaaaaac agcatgtttt tgccgcttta taatatcgtg 1718701 ttaattttgg ttatttttct tggctttatc gcctttcttg ttctgccgga agatacaaat 1718761 ccaaggctgg cgctgctgca tttgattcaa acatcttacg gcggcgtggc acaaggcttt 1718821 gcatatgcca ctatcgctct tgcttcatta ataccttgtt ccattatggc aatcggcgca 1718881 tcgaatttat tcgccaacaa cctataccgg gatttgattc atccgaatgt gtcgcaaagc 1718941 aagctgactc ttgtcacacg ttcaatggtg tttgttgtca tcggtcttgc gctgctgttt 1719001 ggaatgctgt tcccgactgc cttagtgaca cttcagctat taggtgtatc cggtatggtg 1719061 caaatcttcc ctgcgattgc tgtcagcctg ttctggaaaa accaaacgaa agaagcaacg 1719121 gttatcggat tattagccgg cctagcggta acgtttattg tgtatatcac tcaatccgca 1719181 catggcattt atgaaggatt ctggggattg gccgccaaca tgatcgctgt ggtcatcctg 1719241 aatccgctgt tcgttaaaaa cgcgggatcc aatcctgtca ttgaaggttt atttggcaaa 1719301 aaacaagacg ctaatccaaa tcaaaagggc gcataaaaaa accatacgcg gcagccgcgt 1719361 atggtttttt ttacatttct tttttcagtg tttcaattgc cttttccatt tgcgtatcat 1719421 tatcagacag cttcttttga agttctatca ttaatttcgt tgttgtatcg ccagtcagta 1719481 tgcctgtttc attcagcttc tcttttttct ggaactgttt gacgacagat acaaaatcct 1719541 ggtcatacat actgttaacc tttaccttgt aaccaagtgc tttgagcatt ttctgagcca 1719601 ctttgacgtt tgtgcctgta tcacctgatt tgtacgtttt atctgcgtcc aaatacggca 1719661 gcttcgcgta atcaggcagc tctgctttca cttgaggctt gatgcctttt ttgtgaatcc 1719721 attcgccatc agcagtcagc catttggcaa ctgtcagttt gacggtagag ccatcatcat 1719781 attcttttgc cgtttgtact gtacctttgc cgaatgtcgt ctcgccgatt aacggtacgt 1719841 ttgacgattc atgaagggca gcggccataa tttcggctgc gcttgctgta ccgtcattta 1719901 ctaaaacgac ggtcggcttg gtcactttcc gttctttttc ggccttcatg acttcttttg 1719961 aaccgttttt gtattcaacc tgcatgatgt ttttcccttt atcaatgaac aggttgctca 1720021 tcgtaatcgc ctgttccatt aagccgcccg ggttgcctct caagtctaaa atatagcctt 1720081 tggcgccttt tttctctaaa ctgtcaatcg catctgtcag ctctttagct gttgtttcag 1720141 agaaagaagt gatttgaatt tctccgatgt tgttgtcttt catctctgaa tagacagtct 1720201 ctacaggaat ggtatcgcgc ttaatggaaa gatcgatatt ccccactccc gctctgttca 1720261 gttcaagctt cacctttgtg ccctttttgc ctcggattaa agcgacggct tcatttacat 1720321 tcatgccttt tacgcttttt ccatttacct taatgatttg gtccctcggt ttgataccgg 1720381 ctttttcagc aggtgaacct ttaattgggg atacaataag gatttctccg tctttctcct 1720441 ctacttgggc tccgattcct tcaaaagatg ctgaaatcgt ctcgtcgaat gatttcgctt 1720501 gctcttgatc catatatgta gaatacggat catccagtga ttgaatcatt cctttaattg 1720561 ctccgtctac taatttgtca tcatctgttt tttggtaata atcacttttg atttgctcat 1720621 acgctttatt taatttgtcg aacttgctgt ctcctgtgct tgctgatttt tggcccagga 1720681 tactggaatt gcccgtaata aataaagtaa gcgccgaagc gacaactgca gtgatcagca 1720741 caataaaaaa cagttttaat tgccgtttca attaaacacc acctttttct tcttacatta 1720801 ttatcatgga cgaattctta ttcgtcaact cggagcagaa atgaaagaga aacgcccttc 1720861 ttttgctttt cataaaccta tgtctttata cgacatatga taaggaaaaa ggaggattcg 1720921 atattgagcc gatatttaga aatgctgtcc ttattcggtg tcgcaggggc gcacccaggc 1720981 gggctggctt tttcaaaagc ggtcttgcaa aaggctgcac cctctccgga tcagccgatt 1721041 cttgatgccg gatgcggaac agggcaaacg gcggcttatt taggacattt gctgtatcct 1721101 gtaacagtcg ttgataaaga tcctattatg cttgagaaag cgaaaaaaag atttgcgaat 1721161 gaagggcttg ccatccctgc atatcaggcg gagctggaac atctcccgtt ttcttctgag 1721221 tccttttcct gcgtcctgtc agaatcggtc ctcagttttt cacgcctgac atcctctctt 1721281 caagaaattt caagagtttt aaaacccagc gggatgctga ttggtatcga agctgcttta 1721341 aaaaaaccaa tgccccctgc agaaaagaag caaatgatgg atttttacgg atttacttgc 1721401 ttacatgaag aaagcgaatg gcataaactc ctaagatcct atggctttca aaaaacagaa 1721461 gcgatgtcac ttcttccgga agacatggaa tttgaaccaa ccacagaaat ggatttatcg 1721521 caaacgattg atcccatcta ttacgatacg cttcaaacac attatcagct catgcagtta 1721581 tatagtgagt acatgggtca ttgtattttt atcgcgtaca agtaaaacgg cgtatcgccc 1721641 cctgttttcg tccaaccttt ttttcctatc tatcatatgc tgatagaaag tcaggatagg 1721701 aggggaacaa tattggagag atattatcat ctttgcaaaa accatcaagg taaagtcgtc 1721761 agaattacag agagaggcgg gagagttcac gtcggcagaa ttacccgtgt aacaagagac 1721821 agagttttta tagctccggt cggcggaggg ccaagaggtt tcggttacgg atattggggc 1721881 ggttattggg gatatggagc ggcttacggg atttccctcg gtttaattgc aggagtggct 1721941 ctggctggtt tattcttctg gtaagcatag aacaaatgct agattcacca gacacaatga 1722001 agcccgctta tctagtgtaa gcgggctttt cattttaaat tttcttcact ttttcaaagt 1722061 actcttcaag cgttaaatca ttatcttgga tgacctttgc ggcttttttg cctacatagc 1722121 gcagatgcca tggctcatat tcatatttcg tgatatcttc tttatttttc ggatagcgaa 1722181 taataaagcc atatttataa gcattgtcct gcacccattt cccgtctgcc gtgcttccga 1722241 acgcttcatt tagctcaaag ccattgctcc ggctcgaaat gtccatcgca aggcctgttt 1722301 gatgctcgct ttcacccggg taagcgaccg cttcctttgc cttcctttcc ccttttaggc 1722361 ttacttcatt gtcaaaaatg actttctgtc tgtcatacga acggtaccct gagacagctg 1722421 ccagttcata gccttccttt ttggcagcat cgaacattgt ttttaatgcg tcggccgctt 1722481 cttttctgat gtaacgtttt tgaatctttt cttcaaaaga aaactctaca tcaggtatga 1722541 caagatcgct aggttcatag tttccgggca gtgcatattg tttattgaca agcgcgagta 1722601 tattttctgg attttgaatg gtttccagac catcgacttt tttaatatca ttgaaatact 1722661 ggctttccaa tgaaaactca ctgttttgag tgtttgattt tttgctgtca gctgtttttt 1722721 gttctgtttg ctttgtttct gctgtggttt tcgtatcctt ttgagcatct ccgttcgaca 1722781 tgctgcagcc ggctccgact attgccgtta cactcagagc ggcagccagt gagaaccatt 1722841 taccggactt tttcatatta cattaccttc cttttatcaa tcgtttccgc atgcataaag 1722901 aagaggctgc cggcacccag cacgcctctt gatatatttt attgtgatac ggaatgtaaa 1722961 gccacttcta tcatatcatg aaatgtcgtt tgacgctctt ccgctgtcgt ttcttctcct 1723021 gttaatacgt gatcactcac ggtgagaatt gacagggctt ttcttccgtg cttcgctgct 1723081 aatgtataca atgcagttgt ttccatttca acgccaagca caccgtattt tgcaagtttt 1723141 tcaatttgcg aatcgtcatt gtagaactgg tcagctgtaa atacgcttcc tacagtcacc 1723201 ggcacacctt tatcctttgc ggcatcatag gcatttttta aaagctcgaa atctgcgcaa 1723261 ggcgcaaaat caacgcttcc gaaagcaact ctgttcattt gtgaatcagt tgaggaggtc 1723321 atcgccaaaa tgacgtctcg cactttgaca tctttacgaa tagcgccgca ggaaccgact 1723381 cttattagat tttgcacatc gtagctttga attaattcat tcacataaat tgaaatagac 1723441 ggaactccca ttcccgtgcc ttgtactgag atttttttac ctttatatgt acccgtaaat 1723501 ccatacatgc ctctgacttc attgtagcat tctacatttt caagatacgt ttctgcaata 1723561 aattttgctc tgagaggatc tcccggcaaa agcacagtat ccgcaatttg tcctttttca 1723621 gcacctatat gtacactcat ctcatatcct cctgtaaatc taaattatca tccagcccgt 1723681 ccattttaca acgaatgtca tgatgaaaca aacttcagca ttgattataa aggaatatat 1723741 cgaaaaaaga aatgttcgag gatctgttag gcacttcctc agaaaaacgg ataatcgggg 1723801 tgttaatttg aaaacctaac cgcaggaagg aggggtggga catgggtaaa aaacatcgta 1723861 accggatcac cggccaaaaa aagaacaatc atatacctga aaaagatatc attgcagctg 1723921 aagaagcaca cgggaaagaa tattccgctg ccaaacgcaa gccttaaaac tgcagaaaac 1723981 tgcgggtttc cgcagttttc ttttcattat gtcgtttgta caatcagacg attgattttc 1724041 ctccagccgg cgggaagcag ttgataatat gttttccctt ttctgccttc atcaatcagg 1724101 atcacgtccc ctgtggccat gaatcttgca tcataatcac tcggaacagt gtcgaataca 1724161 ttaaacaaag agaatgctct tttcagcacg tcttgatgat cgctcccgtt cagttcagtt 1724221 cgatagacgg ctctgtagcc ctttttttcg ccaaaccggg gtgtctgaaa tattgtcacg 1724281 tcataggaac aagacttctt tttaaacacg gataacatca tcaagatccc ctccctttta 1724341 tttctttaac atattggcgt ttttgctgtg ttttcctctc tctatttttg tcgaaaccgc 1724401 ttaatctttt cgtcaaaacc ttttactagg aaaaacagaa gcaagccgag gctaaagcct 1724461 cctaacacgt ctgtcacaaa atgaaccccc agatacactc tgcttatgcc gactaaaaca 1724521 gcaattacac cggctatgat atataccatt tttttatgct tagacaaaaa cgggagatgt 1724581 ttcactaaaa agtaagcaat aacaggatag acacaagcag cattcatgga atggccgctc 1724641 ggaaaactga aggatgattc atgaaccagc ggtgcaaaat caggcctcac tctttcgatc 1724701 cattctttta agactttgtt taacagccga tctgtgccga atactaagag catcaacagg 1724761 ccgtcccatg tttttctgta gaaaaacatg cctgctccaa tgatgacaat tagagggagc 1724821 agaaaagaag aagcaccaag atgcgtgatc cccgtcatga cttcattaag ccatggctga 1724881 cggatcaaaa cagctgcctt gcttattgct tcatctgcag attgaacagc atttgtatga 1724941 atggccgcag ctagaattaa aaagaaaaga aacaaactaa cgggcttgta caattttaac 1725001 cacctcaatt ttcacagaag tcatagaaca tgaataataa aaccggagct gaccgctccg 1725061 gttttaagcc tcactcatct tcatccagct cttcatctat catacatttt tctatcaaat 1725121 aatcaaaggt aatatcagcg atttcaaaca gctcatcctc actcggtatg tagccccgtc 1725181 ttgcaagctc tctgtaaaaa aattcagcga tttcttccgt atcaatcaca agatctattt 1725241 ctttcatctc cgtaccgcct ccttttttat gttttatgaa aaaacaggct gaattatacc 1725301 cggtgttcta aacaattctt tcagtcatat attgaataaa aaacgagcca tgggaggctg 1725361 acgctatgat tgctaaaatg atggaagcac tggacggaga aagatttgat atcataatgg 1725421 aaaaaacgct caaaggaatg acgcgtgtga tgatttgggg ctgtctgcca tattttttat 1725481 atgtcttgat ccgtatgttc acaaattaac tgaaatgctc ttttaaactt tccaaaacaa 1725541 acatcatcat gtctttatat tcttcatcct gaaacatttc gtacagaatt ttgtagtcat 1725601 tataaatatc cagaagctca tcaacaattg acacagcaag gatgtgaagg gtatcttgat 1725661 cttcatcacc gccttcaaac tgaagaagag cagacgatgc gatatcttcg ccgatctcat 1725721 ggccagtttc tccgacataa tggacaaaca acagctgatg cacaaactgg tccatttcat 1725781 attttctaag caccagcgtg agatcctctt cctccgtttc aagccactct ccatccttta 1725841 aacgggtcag ctcataaatg atatcttccc agccatcttc taaatatctc caaatttctg 1725901 ttctatggcc gataatgcga aagagttctt ttccataatc tttaacataa acaacgtccc 1725961 caataaggaa ttcatactca atatcaagct tctccatgtc gacaatgaca ccctcataat 1726021 ctttataaag ctgaatagat gattcaaagt ataaaacttc gttatgattg acttcataaa 1726081 gatagtgttt atcaatttgg tgtacttttg tgatggtgcc gactgttcca tacataatga 1726141 cgactacgat atcccctact tggaatttcg gtttattttg cttcatggtg tctccccctc 1726201 gccgcaacat ttctcatacg ctatcgtatg ccgggtgaag ccaattcgca tgggcatgaa 1726261 aaccaaagga aatatccaat tatggtatgg gtatggacat aaaaaaatcc gcagtgatct 1726321 gcggatgaaa cagctattat ctgccgtgca cttcagactc gtattgatcc caagcttcat 1726381 caaacgtcgc catcgtgtga aggtaatcag cattcagctc caaatatgaa ctgatttcat 1726441 gataatcggt tgatgttttt ggaaagctgt gatcctcata cgcctgattg gcaaattcac 1726501 tgatgctgtc cttcggctta gggtgtctgt atttcaataa atagtgataa aaggatttca 1726561 tgggtttccc ctcctgatgt ctgtcttttg ttgttctatt atacagttca agtgtaaaat 1726621 tacaacaaaa gaatactgaa acatgactca ggagaagtca aaatagttgc gtttcaaaat 1726681 tctttctgtc tccatgagct gctgatatgt caggctttca ggcagttttt ttgtttgaat 1726741 taaaagcagc tgatcctcaa tctctttaac cgtgttttcc tcttgatagg tcataccgca 1726801 ggaagaacat accatggcag gggtgtctgt cagttctata gccctcgttc catcagggag 1726861 ctcccagtac accgtgttcc tgccgggcac cgcttcgagc tcgccgcacc attcgcatgt 1726921 tttcatgaag aatcccctcc gcattcagtc tctttctgtt ttttctgctg cgccaaaaat 1726981 ttcttttctt tgagctgatc tcttttctca cgccgatctt ttaatgtttc atgctccgga 1727041 tttgcgatgt atgcctctct ccttttgatt ctgtctacat tttcaggtgt aaacgaaact 1727101 tctttgtcag caaaaatggc actcagcccg atcggctcct ttttgtcagc ggtttcaggg 1727161 aaaacggact caaaataggc gtctgcctga ttggggatat aattctctgg ttccggatat 1727221 gacgtaatca caccttcaaa atttcttaag atcactttgt caggactttg tgacaggaca 1727281 tagtttggct gcagggcgat tttacctcct ccgcctggtg cgtcaacgac aaaggtagga 1727341 accgcatagc ctgaggtatg acctctcagc ccttcaatga tctccaaacc tttggaaaca 1727401 ggagctctga aatgccctat tccttctgac agatcacatt ggtaaatata ataaggacgg 1727461 actctgattt ttaccaagtc atgcatgagc tttttcataa ttggaaccga atcattaata 1727521 cctgctaata cgacagcctg atttccgacc ggcactcccg cgttcaccag cttttcacat 1727581 gcctcaacgg attcttctgt catttcgatg cttgtgttaa aatgggtgtt cagccagacc 1727641 ggatgatatt ttttcaatat ctcgcacaga tgatcggtaa tgcgctgcgg aaagacgacg 1727701 ggagctcttg ttccgattct gatgacttcc agatgcggaa tgctgcgcag ctcttttaaa 1727761 atatattcta aaatttggtc gttgatgagc agcccatcac cgcctgaaat taaacaatcg 1727821 cggatttcgg gtgtttcccg gatataagca attgcagcat caagctgttt tttggggacg 1727881 cccattccga tttgtccgga aaagcgcctt cttgtgcagt agcggcagta catggaacat 1727941 tgattcgtga caagaaacag cacacggtcg ggatagcggt gtgtcagacc gggtaccggt 1728001 gaatcttcat cctcatgaag cgggtcttcc agatcgtatt ttgttttgtg catttcttca 1728061 gaaagcggca cagactgcat gcgtaccggg catctcggat tgtcggggtc cattaaagaa 1728121 gcatagtaag gtgtaatatt taaggggatc gttttggtag aaattctgac gccttcctct 1728181 tcatcctcgg tcagattaat gactttcttt aaatcatcta acgttcttac agtgtgtgtc 1728241 agctgccaaa gccaatcgtt ccatttctct tccggaacgt ccttccataa ctcgatctcc 1728301 ttccaatgcc gtttcggttt ataccatttg tttttcaaac gaactcctcc tcgcgcatat 1728361 tttgacttac agttgcttgc accaaatatt catgttttca aggccttcgg ctataaagca 1728421 attattgatc agccttccgc catactgata acctgaatgg tacaacacag cattcatccc 1728481 aaaagacgaa gcacgggcga gagaaaacac atgaacgata tcctctccag ccatttcttt 1728541 ttctaacgcc tcgattaaaa agcttgttaa cgaatggccg cgatattccg gcagcacagc 1728601 gcaatcggtt atttctgcat gcccaagctc tggattgatt tctgcgcttg ctgcgctgat 1728661 caggcggtca tgatcaagca tgatataata caccgtattt gcattcatcg tcttttcaat 1728721 ataagcgggg tcaaataccg gggttgggta cgtgcggaat acttttttat acagcatcga 1728781 tagctggtac atgtcgtttg tttctgcttt tctcatcgta aaaacgggtg tactgtcgtt 1728841 gcgaagacgg ggcgctgtgc gatatatggc ttcgatgatc tcctgttcct ctgtataaga 1728901 atctgtttgt ctccggcttt ctgaaaggta acgtaccatg acacaagccg aatggccgag 1728961 ataatagccc tttagatagc cctccggcgc aaataattgt ttggcaagga tcggctcatc 1729021 atgctgcttc gcatagacaa tgattttttc tgcattctct tcttttgccg ctgccacgat 1729081 atccggcagg gccttctcaa tggctccgtc ataacgaacc actctgattc gtttattaaa 1729141 gccgtcatgg tccaaaactg ctgtgacacc gctactcttt attgacttga gcatccgcat 1729201 cctccccatc tgtatgaagg ccgcaccaat ccatgacaaa aagtgcaata attttagcag 1729261 attctatcat ggcttcaacc tcaatgtatt cattggcctg atgagccgtt tttgtttccc 1729321 ccggcccgaa aacgatcact ggtgtatctc ctgcatggta caaaagccct ccatccgttc 1729381 cccacgggga agcctcaata atcggctctg tctgtttcat tttttgatag gctgattgca 1729441 gcacagaaat taaagggtga tcatcaggta aatcattcgg cagccattga gcgccaaacc 1729501 attcgacttg tacgggatgg cgtttaaacc attcgtcatg gtattctaaa tccttcagcc 1729561 agttttccaa ttcaagtttt acagcttctg gtttctcatg gggagcaatt ccgcatctcc 1729621 cttctatgac gacacggtct gcaactgaag atggccaggc accgcctgag atggtgccga 1729681 tattcaccgg taccggtatt gggatattgt catacagcgg atctgaaatt ctcgcattgc 1729741 ggactttctc cagctcttgt atcgctgtga taacgtgcat gcttttttca atcgcgctta 1729801 ccccttcata gcgtgtgccc ccatgtgcgg ataatccctt cacagtgatc cgaaaccaca 1729861 tcgaaccctg ctgcttaata aatagtttca tattcgtcgg ttcaggaatc agcgccccgt 1729921 cagcacgata gcctctcatg atggcggaaa gtgtaccggc gccgccgcac tcttcatcta 1729981 caacactctg aaacaataca tctcccttca gtttgacatc gcaggcgtgc agggcttcta 1730041 aagcaaaaag aagggctgta ttgcctccct tcatatccgt tgagccgcgg ccgtatattt 1730101 taccgttttc ttcgacagct tgatacggtt catacttcca atcctttacg cttccttcag 1730161 gcacaacatc gatatggccg ttcaaaatca gggacctgcc tccgccggct cccgtttttt 1730221 tagccacgat attcgggctc tcatgaaaat cggatcggtt agatttaaag tagggatgct 1730281 gttttaattg ctttatgctt ggctcccata catcaatgtc catatgaaat tgccgcagct 1730341 tttcaagcac aacagcttgg gcgttaaact ctgaccccaa tgtgcttttt tccccaatca 1730401 gccttttgag aagacgaatg gctttggccg aatgctgatc aagccactcg attacttttc 1730461 tttcaatgtc ttgcatcctc attccccctc ttaagaaaaa ggcatatcta ttttgatttc 1730521 agcttctgtc agcctcgtca cctcatcgat tgtcgagcca ttcatcagct cttttaaaat 1730581 gaagtgatgg ctatcgacct caagaaccgc tttttcggta ataatcaaat ctacacagcc 1730641 tgcagcagtt aatggcagcg tacatctttc tgttaattta ggccttccct tttgatctgt 1730701 atgactcatg acgacaacca cttttttcgc tttttgggca agctccatcg ccccgcccat 1730761 accaggcacc ttttttcccg gaacaagcca atttgccaaa tctcctgatt ggctcacctg 1730821 cagggcgcct aaaatcgtaa tgtcaatttt gccttttctg atcatcgcaa aagacatggt 1730881 tgtatcaaaa taagaagccc cttttacagc gcggacagga tatcccgcgg cgttgcataa 1730941 atgcgcatcc tcttctccct tttcgggact ttctccaatg ccaaggacac cgttttccgc 1731001 ttgaaacatg acctgcatgt caggcttcaa aaagttcggt accaaggaag ggataccgat 1731061 accgagattc acaatcatgc cctgcttaat ttcagtagca gcgcgttttg caatctgttc 1731121 tctttctgct actcccaagc ccatttccac ttcactccct cgcttcgtac aaccccctca 1731181 acaaaaaccc ccggtgtgac aatcatttct tcagaaatct cccccatcgg aacgatacgc 1731241 tcagcttcgg caaaggttct cctggcggcc attgccataa gcgggttcat attgcgcgcg 1731301 gttttgtcat acgttagatt gccgaattca tctgcaatgt aagcattgat gaaagcaaaa 1731361 tcagcagtca gcgcctcttc aatcaagtat cgttttcccg ccactgttac gatgtccttt 1731421 ttttcgcaaa ccatttgatt atcaatgccc acgtcggtta aaataccgcc aagccccgct 1731481 ccgccggcgc gaatccgttc cgcaagcgtt ccctgaggtg aaaattgaac ctctaacgtc 1731541 ccctctgtca tctgttttcc ggctactgga ttggaaccga tatgcgaggc gatcagggtt 1731601 ttgacccgtt gattaacaat aagcgggccg attccgatat ccgggaaacc ggcgtcattg 1731661 caaatcacag tcaaatccgt tacaccgctg tccaatatcg cttcaatcaa tgaaggaggc 1731721 gacccgactc ccccaaaacc gccaaacatc agaaccgatc catcccgaac atctgcaatt 1731781 gctgtgtcaa tgctgattgc tttttgaaat ggcgccattt aatgtcaatc cttttttaag 1731841 tttttttcga ccgctgcaac tgtttctgaa aaaatagaga taagctcttc catttcaccg 1731901 tctgaaatag taaaaggagg agcaataatg acagcatctc cttctccact gtctattcca 1731961 gctttggaag gataaacaat cagcccgcgt tttttcgcct cgctgacaat aagctgggtt 1732021 atcgcctgct ctggcggaaa cactttcttc gttttttggt ctgccacaaa ttcaatgcct 1732081 aatagcagtc cttttccgcg cacctcacct ataatgccgc tttgagatgc cgcctcatca 1732141 agcttcttct tcagcacagc gccctttttt tctgattgtt tgatcaagcc gtgctttaac 1732201 acatatcgca aaacttcaag agcagctttg gctgaatagg gatgtgcact atatgtgtga 1732261 ccgctcataa tcacacctga cccttgtttt atggtttcaa taatagaatc agatacgacg 1732321 gcagcagcaa taggtgcata ccccgcaccg agtcccttcc ccagtacagc aatatcaggt 1732381 acggtatccc aatgctctgt cgcgagcatc cttcctgttc tcccaagccc cgtcatcact 1732441 tcatctgcaa taaaaagcac atcgtgtgtg cggcatacct cacttaatct ctcataatat 1732501 cccggaggcg gagtaatcgc tgctcctgca gcaccaataa taggctcagc cacaaagccg 1732561 gcgatgaatt ggcttccgat tcttttaatc atggtgtcca gttcatcagc tgcagtctga 1732621 acaaagtctt cttccgtctc gtgattcagc cgataaatat gtggagctga gatagctgga 1732681 taccgctcaa tgagatgggt gaaccggtat ctcctttcat aaaaaccaga caatgaaagc 1732741 gctcccaaag ttattccgtg gtaactgctc catcgagaca aaaagatgga tttttgtgtt 1732801 tgcttttttt cctgccaata ctgaatggcg attttcatag ctgtttctat cgcttctgat 1732861 ccgctgttga caaaaaaaga ccaattcaca tctccgggca gctcctgtgc caagagagcg 1732921 gctaattgct cggcgggctc actcgtaaac tgtgagcggt aagcaaaaga cacctgatca 1732981 agctgttctt tcagcttctc agtcacatca cgaactccgt ggccgatatt acatgtcacc 1733041 gcacctgacg agccgtcgag atattttttt ccggtctgat cataaacata tgaacccttc 1733101 gcataactga caaccggata ggccgagcta agctctggct taatcaaata actgctcatg 1733161 ctcccacctc aaaacccctt ttaccatatt gtatgagtgt ccaaatggcg gcatgacgtt 1733221 ccccgcaaaa actttttcac ataaaaagag ccttcctaat aaggaaggct cttttgaaat 1733281 ttcagcatct agcaaataaa agcggctcca acaataatta ataaaatgaa caagacaaca 1733341 attaacacaa atgtatttgt cccgcagcca aatccgtaac cgtacccaga gtatccatac 1733401 atgctgtttt catcctttct tatcacgata tacgacattt tatgcgggcc aagtcccaaa 1733461 tggtttgtgc aaacgcctat ttcatgtaag gaaataatga aatacagtat gcacccgctc 1733521 atatttttta aacgtcagct tttcgtaaaa ctgagttgca ccgtcagtgc ttgcagccac 1733581 taagtaggct gcttccattc ctagtgattt ggcgatggac agcatttctt tcactaagat 1733641 actgccgtag cccttccttt gaaactgatc taaaattgcc acttcttcga ttttagccgt 1733701 tttctcttga tgatcgataa acagctcgcc gcacccaatg ggaactttct gtgcctggtc 1733761 gctgtaacaa acaacaagaa tgattatatc tgcttcatag aaaggatatt ttctttttaa 1733821 tttttgttca gcgattgctt ctccaatata aatggaatcg taaattttca taatagaaga 1733881 tccgtcgcta agactttttg ccgtccccca tgcggttaaa ggatgtccca tctgcccctt 1733941 ccagtcacta agcttcatgt catatagtag ctcatcctcg acgacaaaac cgctttttac 1734001 aagtgactgc ttcaaaccga gcggaaaaac atgctgcggc gacgctttta aatggagata 1734061 attcgcatca agcagctttg gtacggaggg taaaaagtta agtaaccgct ccaatggaaa 1734121 cgtatcatgg agctgaacaa agttatgaga aaaaatttgc ggaagctgcg gatctctgta 1734181 tacgctgtaa tgatcaaacg atgccgattc agacgttaac aatatatatt gatgttccgt 1734241 ttttgaataa tgtcctgtca tgaacgtctc ctttttatga cctatacctt tactctgttg 1734301 caatattcaa tttctttata atctcatcgt acaccggata aaacggcttt ccaattggaa 1734361 attgctgaat atttcggaaa gaagcggaga ttggcttctg atgtaaaaaa aacttccttg 1734421 ttacttgttc actaatcggg tgaaagacgc cgtttagaaa caaaaacggc tcgcgttcga 1734481 tgaaaaacag acgtcggcca ggcggatttt tgatcaattc agatcgtttc cacgtaatcg 1734541 gcggcccttc cggaagcgtc tccatctctt cttttccaat tgtcactatg tcttttcttt 1734601 gaaattgata aaattgaaac gcatactggt ccacaattcg cctttttttt ccggcttcga 1734661 tataaaatat tgcaggatgg tcagcttcct ttactaaaat ataattcgga atgtttaaaa 1734721 ttttgccaat cctatattgg aataaatatg ggtctggaac agcgacagtc cgatttagat 1734781 acaaaaaacc ccacttttct ccaacaggat gccttacacc ctgatcaaaa aaatacacat 1734841 tttgatctga accttttaca aaagagccgt caatcaaatc ggcgggcaga aaccgatatg 1734901 cattttgaaa tgaatctggg gttttatagg ttgtgtctaa tacttcattt atcggcagaa 1734961 atggggtaaa gttgttgagt ctcgcccaaa aaattgcgtc gccatgattc caatgcttca 1735021 tatcatcatc ccagtagcct ccaaatttat ggtgaatgag attaagtaac gaacggcgat 1735081 gcataactga gcaatgatca acttgaaaag cggcctgatc aagcactgca ttggcatttc 1735141 tgtagaaatg tgagatttcc tctccccttt cgtttacatg tacaactttt tgttttgaat 1735201 agaccgcctg cgcttcaggc ttatgtgaaa actcttgcac catacggctc agccgctcag 1735261 gatgataaac agtgtcgtca gtaagatagg aaatgtaatc gccgtctgca aatgggagcg 1735321 cactgttaat taatgtggca taacgggctg tttttaatcg atctgcagga tgcacgaaac 1735381 tgttatgata ttgaatgcgc cggtcatgga gatacttgtg aatcaccgca gttgtttctg 1735441 cattcgaatg atcatccatg ataaaaagct cccaaagatc atgcgtttgc tgtatcacgc 1735501 tttcgatcgc tttttgcaaa taatcgggtt tgttgtaact tgttaaaata atagacactt 1735561 tctctcccat ctataccgcc tcccgccgtc aaacataaaa acggctccgc agcaagcaga 1735621 gcctctgtca tcatttaaaa agcaccccag cttacaacac ttgagagtga aacatgagat 1735681 ctcgtgttat ttaacgggtt ttggaaaata accaaatcag tcagaacttc ttttacgatg 1735741 acattttgaa gtgtatctcc gttgatcaaa ttgacttttg aaaccggtac gcccagctct 1735801 tttgcaaaaa caagctggcg tctgaggtca gatggatttc cttcagaaga cgattgacgt 1735861 atcagcagaa tcagcaaaag caaaataaaa tgcagatcat cttggttttc ttctcgatcc 1735921 acttgtttct ctaaatccaa atcatccctc tcccttatcc ttatctctgt ttcacaatat 1735981 gtgcgacttc gatttatggt ataggctatg tccactccat taaaaaatca gcattttcct 1736041 taaatagatg aaaaatagat caggtacggc gttcgactca taccaaataa cagccggaag 1736101 aatatgaata acgtgagttc actatcgaat aggaggtgtg tgtaatgagc tctgaaaatg 1736161 cacagttaaa aaaggattta attaaagccg ttttaagccc tttatttcca actgcaacag 1736221 aaggaggaga aaatatggat agtaatctta aagccttgct tgatgctgcc atcgatcaaa 1736281 aagtagatga aagtgaaacg gttacggcag aatctatttt agacccttct cttccggcaa 1736341 gatggatttt tgccagaatt acgccaggca ctacaatcag cattgtgact gattcaggtg 1736401 acatgatcgg accggttgtt ttcgttgctt tcgatcaggt tcacgggatc gtatttgtaa 1736461 cacaggaaag ctccgtcact ccggcaggcc aagctacaac attaattgat gtagacaaag 1736521 tagaaagcgt tacgttcttt tcataacatc cgatgaaagt cttgtatatc cagtcgggat 1736581 acggaggaat atacagttat tttgatcgct gggctgaaga atgttttcag aacactcata 1736641 cagagtatat gattgcagat aaacctgaag cagaatcttt gatgaagatc gaagcgtttc 1736701 agccggattt cacacttatg atggttggag accgcgttcc tcacgactgg ctgacctggt 1736761 taaagggtaa ggatatcccc gtgtatgttt ggctgaccga agacccattt tatatggata 1736821 tcagccttca ggtaattaag cttgctgacg ccatattaac gatagaacaa aatgcagctc 1736881 tctactatca agagctcggc taccagaacg tctattatgt tccgatacca gttaaccatc 1736941 ggctgtttaa aaaaatgggc accgaacatt cctatcattc aaatctgtta atcatcggct 1737001 atccttaccc taatcgggtt cagcttatga aagaagcggt ccatctgcca ttcacggttc 1737061 gggtaatcgg caaggaatgg ggaaaatatc tgcctaaaaa agtgctcaaa cagccgcata 1737121 ttgatgtcgt cagcacatgg gttccacccg aacaggccgt tcattattat aatggggcag 1737181 acatcgtaat taatgcgcat cgtccctatc attttgcttt caaccaaaat actatgcgca 1737241 tcaaaaatgc cagttttaat aaccgaacgt ttgatatcgc tgcatgcgaa gcatttcaat 1737301 taacagattt acccgcggcg catccttttt catccattat ttcttatcac ggcatgaacg 1737361 actttaagga aaaagccgct ttctatatca accaccctga agaacggcaa aaagctgcag 1737421 cagccaatta taaagagacc gtacccgcat ttacgtttga tgagcttcct gcaaaactaa 1737481 aagcgattca tctggcgctt tcttgaaaaa tcgttcattg ctatgaacga tttttttatt 1737541 catagaaaaa agcagctgca caagctgctt tctattctag ccgtcagaac ggtctttcag 1737601 cttcctcgga tttacctgtt tatgaagatc aggcatttcg ccgagatgct gtgcaatttg 1737661 ttcccacgat acaattttga aattttgatt gacggcttgt ccgttatcaa tattttcgcc 1737721 gtcctgcgcc acaaaaatcc cgtacggata ttttgggcca agtccgaaac cgagaacatc 1737781 aataccatcc gtgtcactag taccgtctat cttctcgcca tctgtaatct caaagttggc 1737841 tacatagcga tttttcccct gccgttcata cattgcatag ctgttatttc cttgacttga 1737901 agccatgaga tatcctttgc catttggtgc ataatagatt gtcagtcctt caatatcagc 1737961 tgtcaaatga tctcctgtcg cacggtcaac aacctgcccc tttgaccctc cgccgggctc 1738021 agcgttaaat ttccagatgg cctcatcttc ctctgctatg tataggtttc cgtactcatc 1738081 atccgcaaca aggccttcgg tctgagaatt caacttaaat tcacgcacct ttttccctgt 1738141 tacataaccc tttccaccat caacaatttc atactgctca aattcccctt gtttgcctgt 1738201 cactaatgcg taaaatgctc ctgttttctg gctgtgatac aagctgaatc cataaacctc 1738261 agaaatattg gtggaaatag gatggttcgg atctgtaatg cttttcaatt ttcctttatc 1738321 cccgtctatt gcatatactt caattgtatt ttttccttcg gaccggttgg atgcggcagc 1738381 aatatcaatt ttttcgccgt tcaatggaaa atcatagcgc agatcgacat tattgagctt 1738441 gccaaactca taagaatgaa gctgttttcc gtctaaatca tacacaacga gccctgactt 1738501 cttatttgtt gtaatcaact tgcttttttc cgggtgtttt tcatgaaccc aaatggccgg 1738561 gtcatctgct gcatcatcgc cagatgcgac cggatctgtc tccgtgtgtg cagtcacttt 1738621 gaaatgatgt tcctcattca cataatgagc cgacaccgag gttgctgtca ggctaagcaa 1738681 taaacccgcg gcagtgctta gcagcattgt ttttggaacc ttcatttggt accctcctct 1738741 tttatcacta acactactat tgtaaaatat atacaggtga ttaccgtgag gaaaatgaac 1738801 ctttttttat agggtttctg actcataaac aacttattcc ccaaagaggt ggtgagatga 1738861 ctttgccaga tttacttttg cggagcgaaa taaaaatatg ttgaatattt agtacattat 1738921 ttatttagtt ttgtttttcc ctagttacgt ccgtttttcc attttctatt aaaaaagaac 1738981 actttgtgac atgatcattc ccctaaattt tgttttattg gttgctttca ttaattcgat 1739041 tacaaagttg aacatatgat gcatggtaga gaaacgagag ttggaggata agccatgcct 1739101 aaacagcaaa cagcagaact aaaaccattt ttccataaca aaacagtttt agtcactggc 1739161 ggaacgggtt caatcgggag tcaaattgtc aaacgccttt tgatgcttac acctaaacag 1739221 gtgattgtat tcagcaaaga cgacagtaaa cagtatgtca tgagccaaaa gtatgcggag 1739281 gataagcggc tattatttgt acttggagat gtacgcgatc acagaagggt gaatcaggtg 1739341 atgaaaggcg tcgatatcgt ctttcacgcg gctgcgctga aacaggttcc gacatgtgag 1739401 gaccatccat ttgaagcgat ccagaccaat ctcatcggcg gacaaaatgt ggtggaagct 1739461 gccctttcac accgagtgca gcatgtcatt aatatcagta cagataaagc tgtatctcct 1739521 gtgaacacaa tgggtgccac caagctgtta tctgaaaagc tgtttcatca agcaaaccgc 1739581 cacgtccaaa acaaaggaac cttgttttgt tcggtccgct ttggaaatgt tctcggttcc 1739641 agaggttcgg tcatccccat attatttgaa cagatgatgg agggtgaacc tctgaccatc 1739701 acagacaaaa acatgaccag atttttcatg tcaatagacg atgcagctac attgacatta 1739761 caatcggctg ctattacaaa aggcggagaa acctttattt tcaaaatgga atcactgaaa 1739821 cttgaagaac tgattcatgg gtttgaagaa tatgcatcgc agcacgggct cccgcggccg 1739881 gctgcagtag aagtgggcaa gcgtccaggt gaaaagcttc acgaagaatt aacatctcca 1739941 catgaaattg aatcactgta tgaatggggc aacctttatg cgatccttcc agagccggaa 1740001 aaacatcctg actttcgcaa agtcaatctg cctgggtatc aatcagatca agccccgctc 1740061 attacgaaag aaagaattgc tcagattatt gaagaattgc atcaagagaa aaaggcataa 1740121 aaacaagcct gtctatccat taggcaggcc tgtttttaac agtttattta ttaaagagat 1740181 gcagatagct ttcgtatcct tcttctttta gcttatgctt cggaacaaac cgcagcgctg 1740241 ctgaatttat gcagtaacga agtccgtttg gccccggtcc gtcattaaat acgtggccaa 1740301 gatgagaatc agcagttcgg cttcttactt ctgtgcgaat catgccgtgg ctcgtgtcca 1740361 gtttttcttc cacttcttct tcaatcggct ttgtaaagct tggccagccg cattgggaat 1740421 caaatttatc tttggatgta aacaatggct tgcctgacac aatgtctaca tacaaccctt 1740481 cttccttatg atcccaatat tcattttgaa atggcggctc cgtgccgtta ttttgcgtta 1740541 cttcatattg catgcgattt aatgacttta ttttttcttc tttattgtac gccatttatt 1740601 tagcccccca atgctcgctg ataaatcccg ctcgtccgga acctgtccgg tagcgctgat 1740661 aatgtgctgg attcttttta taaaaatgct gatggtagcc ttccgcttca tagaaaggtt 1740721 cagcttttaa aatgtccgtt acaatcggat ctttaaagat gccgctttcc gccagacgtt 1740781 gcttggaagc ttccgcaagc tccttttgtt tatcattatg ataaaaaatg gctgcgcgat 1740841 aggaactgcc gcgatcagca aattgccctc cggcatctgt cggatcgatt tgctgccaaa 1740901 ataattcaag cagtttttca taagggaata catcaggatg aaacgtgatt tgaacggctt 1740961 cacgatgtcc cgtcgtttca ctgcacacct cttcgtacgt agggttttca gtatggccgc 1741021 ctgtataccc ggacaccact ttttcaattc ccggctgttc gtcaaaaggt ttaaccatac 1741081 accaaaaaca gcctcctgca aatgtggcga tttctttttt ttcagacata ctggtgcctc 1741141 ctttgttaat acgtggtatt attatattat agcatgtaaa aatagaatga aaatgattct 1741201 gcttttcaat aaaatctata ggttttaagc aatatgctta tgtaatggag gttcacaaat 1741261 ttgaaagtaa gaacacagat gatgtacgat atggaaactt tactccgtaa agtctttaaa 1741321 caaatacgca atgaaatcaa tgaaatttta gataaagagc tgtcgcggaa tgaattcacc 1741381 attcttcgaa tccttagtga acaagggcct aaaaaagtca ctgaatttgc gcctatttta 1741441 gaggtatcgg caagccacat tacggctgtg accgatgcgc tggtagaaaa ggaatggatt 1741501 acgagaatca gatcgaagga agacagacgc atcatccgca ttcatatcac tgaagcgggc 1741561 gaaaaagtcc ttcagcactt taacgagaaa aaaacggaat atttctttaa acgctttgac 1741621 tgctacactg atgctgaact tgccacgtta atcgagctct tcagcaaact tgataaaaaa 1741681 cggtgaaaaa aagcacatac cgatatatag gtatgtgctt ttcgcagtgc ttcacttatt 1741741 tttcagtaaa cagcttcatt gctttccagc ggccatatct ataatacaaa aatgccgcgc 1741801 agctgctaaa taaaaaactc attccgattc caagcccgat tcctttttgt ccaagccaag 1741861 ctgaaaatag agctgtgaaa ggatacctca acacccaaaa cgagatcaaa tttaatacca 1741921 gaacctgcag catcgctccc gcggccctga cgattccgtt cagcacaaaa ttaaccccaa 1741981 taaaagggta gaaaaacgcg atccacttca aatattgttc accaaatgcg accgcatcag 1742041 gctcactgat aaataacctt atgaggtatt taccaaatac ccaaatcata accgcaatca 1742101 ccagcatgca ggaaataaca gctatcacac ctagccttgc aattgttccc actctttttt 1742161 cgtttccgat tccaatattt tgccctgcca tactattgac ggccgtaccg gcagccattg 1742221 ctggaagcgt gatgatgcta tcaagccgct gcaccgcgcc aaagcctgat accacgtgat 1742281 ccccgtatga gttaacaaca ctcataatcg ccatcatacc gcctgtaatc accatcatct 1742341 gcagacctgc cggaatcccg agtttcaaaa tcagcgcgga ctcttcccac ttgggcattc 1742401 tcggaatcga gaatggcaca agcttgtgtt tgatgacata aaacaaccca tacaaaaacg 1742461 caatgccctg tgacaaaatc gttgaataag ccgctcccgc tattcccatg cggaacacag 1742521 aaataaagag cggcgcaagc actgtattca gtacaacagc aaacgcaata aaccggagag 1742581 gtgtcttgct gtcgcccagc gcacgaagca cagtactgat aaagttataa ccaaacaaaa 1742641 ataaaatgcc gataaattga atctgtaaat acgtctcagc aagcggtatc attgactccg 1742701 gcgtttttag aagacgcagc aaaagctctg agagaaaaaa accggccgcg ccgaatccga 1742761 tgcttaggcc tgttaataaa acaacaaaag cgttaatata cgacgccatt ccttttatat 1742821 catcttttcc tttttgctga gataaaatgg ttaacgtcgc attgttaagg cccaaaataa 1742881 aagacagcac ggtcaaaaca atcgtgcttg ataccgcggc tgccccaagg gcctttgccc 1742941 ccagtaaatt gccgatccac aagctgtcta taaattgaaa ggaaacctgc aatgcgtttc 1743001 cgagcataat aggcattgaa aacagtacaa gctgtttcag cacgttcccc tgtgtaaaat 1743061 cgtatgcttt catcttttct ccttgtgttc tcaaattttc ttcggaccac acgaaaaaag 1743121 agacgttgtt tcatgtctct tttttcatga cttatcggtt ttttttcggt ctcgcatacc 1743181 gaatgtaaac accatcacac ttaggaacaa ggcacaatag gaaacattca aatacatttg 1743241 atccatatct tcagcagcca gatgatgata agcaagccag ccgaagtaca gggaaaatgt 1743301 aaaggataat aaactgaaat actggtaaat ccgtttcatt ttcagtcacc tctattgttt 1743361 aggatggtaa taggaaaact caatttcatc tttttctaaa tttatcttat ccgctttgac 1743421 atacattcca ttcgttaaag gcatttctga caaacgcact tcaatgcttt tatctccggg 1743481 gtgaacatgg acaaatgacg gcaattcata aaagctgtcc atataattta acacaaagct 1743541 aattggtata ctcaatttcc ctaacgaaaa tttcgtgaca ttcagctcta catcaccgtt 1743601 ttttttcacg gtcggctcaa aagcgataaa cgcatcaata gacgtggaaa atgccttgat 1743661 tttccctgcg acatgaacat catcatcaat ctctacttta taatcaagct tgtttgatgc 1743721 tttgtcgttt aaatatgagt taacaaacgc agctaatgat tcttttgtgc ttgtcacttg 1743781 aaatccatac tcgctctcag atgcatcttt cacctgagcc tgttcccccg gaagcaaaac 1743841 aagtgccaca aacccggcgg cgaggataaa attgattgca agcaatataa aaaacagtcg 1743901 cttccactta ttcatgctgt caccctactc tttcggtaat ccttcttttt taatggcttg 1743961 atagacgcgc tttgcgataa gagaataacc cgtaccatta ggatgaaaat catcttcctc 1744021 agaaattcgg ctgctgtcac ttttttgatt aaacaaatct tcgatatgga cgatttttgc 1744081 atgtttatct tttttcagct ctttttcagc aatatggttc caatccgtga cgacaccatt 1744141 tatttcattt agttctgata atgtaaacgt aaacggattg tacatgctga cataaatcag 1744201 ctcagcgtga tcattcagct cgcgaatttc agaaatgatt ttttcaaagc gcttttcgta 1744261 cggtttttcc gcttcctgaa acggttcaac ggttaattgc agaaagtttt ggcgaaggat 1744321 tttcatcaaa tcattaccgc caattgtaaa aaagacataa tctgcgtcct ttatgccttt 1744381 ttgaaccttt ttatctttta gtttttctaa taaatcatcc gaacggttcc cttttacagc 1744441 ataatttttc acgtcgaccg ttttgacttg tttatctgac cggatagaat ccgccacctt 1744501 gccgacatat ccctttccgt cgggatctcc gactccttct gtcagcgaat ctccgacagc 1744561 cgctatgaca atgtgttctt ttgttttcgt ttcatgggct ttttgttttc cctcagatga 1744621 tgtacgtatg ctcgtacacg cagtaagaag caaaatcaaa ctggccatga ttgaaaaaat 1744681 gcgcagcttc aatcttgttg ctccttccca ttctactagt ggaaagtgta tcatgtttta 1744741 gaagatttgc aaatgcctag tctcttagct tacttgagtg tactggctga cttcacatcg 1744801 gaaatgatat catcgtacgg tgtattctcc actccattgt aatctttcag caccttaccg 1744861 tccggaccta ccaaataaaa agaagattga tgaatcactt ggtcctctcc ctccggcttc 1744921 tttacgatcg ctttaaagct cttaagtgcg aactcctcaa tctcactctg gctgtatccc 1744981 gtgagaaaat cccagttatc aaaagataat ggataatttg cggcaaattt cttcagctgt 1745041 ttcggcttat cgttttctgg atcaacacta aatgatatga tgcggacatc tatattttcg 1745101 gctttcagtt ttttttgcag atcggtcata tgagcggtca ttggcggaca tatagtttca 1745161 caattggtaa aaataaaatc cgccagccat acttctcctt ttaaactctc taaagaaacg 1745221 ttcttgccgt cttggttttg aaatgtaaaa ggctccacct cgtaattgag cggatcttta 1745281 atctgctgtc ctccgcatgc acacaaaaac agaaaaatca gcccagccgt taaccccttg 1745341 ataaccttca tgacatccat cctttccagc cagcataaaa acgctttcta aaaccgtcct 1745401 tactgtccca tgtttgtatt cgatactgag caaaaaaaat cctgcatgcc tccccattaa 1745461 cgattacaaa ggagggcatg caggtaaaaa acggcatgtt acgcgttgtg ctttaacacc 1745521 tcttgatgaa atacagcctg ataatctgcc cacttcatcc gccgcttcat ataatgtcgg 1745581 aaagaataca cttttgccct gctgtttgat gaaaacactt cttttaagta gaattgcaaa 1745641 tggtgatgta acataaagaa atagtgctca tcttccttta atacaggtat ttctgtcact 1745701 ttcacctgaa tcccgtcacc gcgtttgaac tctaggcttt tgagtaacaa gctatcaatc 1745761 ctcttttttg tttttcttct attatatatg atgccagccg ggctgtctgt cattttgcgc 1745821 ggttgtgtaa aaaaattaga ttagcaaatg gaacaagtcc tcatccttgt tcacctctac 1745881 ataatgaaac ggttttttgt tcatccgttc aatcagcggc ccataatcgg ctttgttctg 1745941 cagctcgatg ccgacaagag caggtccatt gcttttatta tttttcttcg tatattcaaa 1746001 ccttgtaatg tcatcattcg gcccgaggac ttcgtcaaga aattcgcgga gcgcccccgc 1746061 tctttgtgga aaattgacga taaaataatg ctgaaggcct tcaaaaatca aggaacgctc 1746121 cttcatttcc tgcattcttc cgatatcgtt attgcccccg cttaccacac acaccacgtt 1746181 tttcccttta atttgatcct tgtacaaatc aagcgctgcg acagaaagag ctccagccgg 1746241 ttcagcaaca accgcacatt cgttatataa ttcaagaatg gatgtacata cttttccttc 1746301 aggcacaagg agaatgtcat caacgacagt ttccagcgtc cggaaggttt cctcgccaat 1746361 ttttttaaca gccgccccat ctacaaactt atcaatttta tcaagtgtga cgacatgccc 1746421 agctttgttt gattcaaagt aggatgccgc tcccgccggc tcaacagcaa ttacctttgt 1746481 atcaggagac acgtttttca aatatgtacc taccccagag agaaggccgc cgcctccgac 1746541 acttgcaaaa agaaaatgcg gttctgtatc aatgtcgttt aaaatctcga ctgcgagcgt 1746601 tccctgtccg gccatcacat ccggatcatc gaacggatgg ataaacgtcc gagattccgc 1746661 ctcacagcat tcagcagcgc ttttatacgc gtcgtcaaac gtatcgcctg tcaaaataat 1746721 atcgataaat ccttttccga atagttcaac ttgagatact ttttgtctcg gtgtagtaga 1746781 cggcataaaa attttcccgt gaatgccaag atgtttacac gaaaatgcca caccttgagc 1746841 gtggtttccg gcacttgcac acacaactcc gttctctgtc tgctcgctgg aaagctgttt 1746901 cattttatga taagcccctc tgagcttaaa agatctgaca acttgcaagt cttcgcgttt 1746961 taaatagata ttgcattcat atctctcaga aagtctgtca ttcctctgca aaggtgtgtg 1747021 aatgacaacg tcctttacgt tttggtgagc cttcaaaatg tctttcactt ggatgagaga 1747081 gttttcttta agcaacggtt tcatgtacag attcctttct tgttttaaat ccctatttaa 1747141 tatgccatta taacatgaat attcaaaaaa taagacaatt atttttattt aataattaaa 1747201 aaaatacaga ctatgtccac cacatcttgt ggtaacttct gttcaaccat tatcctgcag 1747261 agccaagaaa aaagatgatc gtaaaataaa gggtgttttc aaccaaaagg catgatataa 1747321 tgaaaccaat tagaaccaaa aggagccaat tgatgaatag tgcaccaaaa ctcaatacat 1747381 ttcaacatct aatcggagaa catcaaactt ttctggaagc gaagcgaatc gccaagcagt 1747441 tctcgttatc ggagcttcct gtcttaataa caggaaaaat cggaacaggc aaaaatcact 1747501 tcgcacatgc catacacttg gaatcttcga gaagcaatga accgtttata agcgtcaatt 1747561 gcagcaccca ttcggaagaa acccttattc atgagctttt tggccctaac ggaaacacag 1747621 gtgtttttca aaaagcggta cgaggaaccc tttttcttga tgatgtatgg cgcatgcctg 1747681 cttctgtaca agctcagctg ttaaaagcgc ttgattcaga cacggagaaa ccgcgaatga 1747741 tctgtgcttc tgcagaccga tccgtggaac atacattcag gcaagactta ttctacagac 1747801 tgaacatttt aacgctcaca ctgcccgaat tatcggaacg aaaaagcgat attccgcttt 1747861 tgacacagca ttttctctca aattctggtc agcaattgtt aatcgatccc tccgtttttc 1747921 ccgtgcttga gaagcatgca tttgaaggca atgtcaggga attaaaaaac gctgcagatt 1747981 atatggcggc agtatcaagc gggggaacga ttcagccata tgacctgccg ccgtatatta 1748041 gaggcacgat agacggaaaa acgtcgaaga aaaaagcgaa actgcttact ttaatggaaa 1748101 aagctgagtt tttgtttatt ttggaaacaa taaaagtatt gaacgaaaaa ggagaacctg 1748161 ccagcagacg gatcatttct gaacacagca aaaataccca aacctcgtta actcctcagc 1748221 aggtcagaag ccgtctcgac tatttggaga aaaaagatta tgtcaccaaa agccgcggac 1748281 gcgcaggcac aaaaattacc tttgagggct tgagctttat agagacgtta aaaaatcaaa 1748341 tgatctagcg atcgaaagga gaatgtactt gtttacaatc aaagaagaga tcgccaatgc 1748401 gattacacac ggcatcggtg tcctcttatc catcccagca ttagtgtttc taatcatatt 1748461 tgcggctaat tacgggtctg catgggacat tgtcagcttt acaatattcg gtgtctctat 1748521 gctgctgtta tatttgagct ccaccctgct tcacagcatc acacataaaa aaacgaagga 1748581 cattttggag attattgatc atagcgcaat ttacgtactc atcgccggaa cctacacgcc 1748641 ttttttgctt gggccgctga aaggcacact cggctttacc ctgttggtta tcgtatggtc 1748701 acttgcccta ggcggaatcg tttttaaaat tttctttgtg aaacggttta tcctattgtc 1748761 aaccttcgtg tatttagtca tggggtggct gatgattatt gcagttaaac ctttatatgc 1748821 ttcactgagc ggagcgggat tcagcctcct ttttctcggc ggcattttat actctgtcgg 1748881 aaccatcttt tacatttgga aaaagatccc cttccatcac gccatttggc acagctttgt 1748941 attgggcggg agcgctgcca tgtttttctg cgtgctcttc tattgtgtaa aggtgccttt 1749001 cctttcgtaa cagtaacaga aaagcgcagt cttcacgact gcgctttttt atgcacgtaa 1749061 ttgtttttca ttggcaggta tataagcttt tgaaaaggac aattcaatgt ctgccggttt 1749121 taagcgttta aaaaacgagc cattttgcat gttatctgtt cctttcgttt ccaccatcac 1749181 caacggaaga tgatagcggg ccgcaagttc tacaggatca atagaaccat ctagtgaaag 1749241 aatcaggctt tgtccctttt ccagctgttt tgtcacatct tcatatacct tttctgaatc 1749301 cccgtctgaa atcacatcca tccgatccag ccattgcccg ataaaaggca agcggaacac 1749361 ttttgggtta gcgataaagc cggccggttc ctcaatatat ccagcaatta aggccagttc 1749421 agccaaacgc aaacggggat gcacatacaa aacaggaccg tgtggtattg gctctggctg 1749481 atggatcgtc acaactgaac cggagatgcc gatacagcct tctaaaaacg cctttggctg 1749541 ttcgtacaca agagccatct gttttttgta tgacagacgg ggatcgagca ttgtttgatt 1749601 aaataattgt ttcatatttt ttaacagcat atacacaata taaaccacta gaaggctgta 1749661 gcgaaccaat taaaatcctc ccgctttaga agaattcttt ttttcataca ttagaaattc 1749721 gtaatcatac gggttttttt cgtctttggt cccctgctca gaagaaacca gcttccaatt 1749781 ggattcatca aattcaggaa agtgacggtc accctcaaac tcgtgatgaa ttttcgtcat 1749841 atacagtctg tccgcataag ggaacaggtc cgtatagagc tgagcccctc cgatcacaaa 1749901 gcattcttca gggcctgaac aaatgtccag tacatccttt aatgaactga caaccgtgca 1749961 tccctgaaat tctgaatccg gcgctgaggt aacgacaata tttttccgat ttggaagcgg 1750021 acgtccgatc gattcaaatg ttttccggcc cataatgatt gaatggcccg atgttatttt 1750081 cttaaagtat gcaagatcat tgggcaaatg ccacggcaaa tcattgtctt tgccgataag 1750141 cctgttggca tccatcgcaa aaatgaatga aatcatacgc tgaccgcccc ttttatatga 1750201 ggatgcggat cataatcctc gatgataaag tcctcaaatg caaagttaaa aatagaatca 1750261 acctttctgg cgaaacgaag ctgcggaagc ggtctaacat ctctttccag ctgcaaattg 1750321 acttgttcaa tatgattttg gtaaatatga acatcaccaa acgtatggat gaactcgccc 1750381 ggttcaagcc cagtcacatg agcaatgatc atggttagga gggcataaga tgcaatatta 1750441 aacggcacac ctaagaaaac atcggcagag cgctgataca gctgacagga cagcttgccg 1750501 tcagacacat agaattggaa caggcaatgg cacggcggca acgccatttt atcaatttca 1750561 ccaacattcc aggcgctgac gattaagcgt ctggagttcg gatttgtttt aatatcttca 1750621 ataagacggg aaatttgatc aatggtttct ccatcagctc cccgccaaga acgccattgg 1750681 gagccatata caggtccaag ttcaccgttt tcatcagccc actcattcca gattcgcact 1750741 ccgttttcct gcagatagcg tacattcgta tctcctttta agaaccacag cagttcatgc 1750801 gcaattgatt taaagtggag ttttttagtg gtgagcatcg gaaagccttc ccgtaaatta 1750861 aatctcattt gatatccgaa agtgctgatt gttccggtcc cagtccggtc tccctttttc 1750921 tcaccatgct ctaaaacatg tctgcagaaa tccttatact gtttcatttt tttcatcctt 1750981 taaaagtagt cttctagtag tgtaacacaa taaaaaatca tttctgaacc cagaaatgat 1751041 ttttttatag tcagctgacg acaggctttt catcctgttc tttttcttca tcttgcagat 1751101 cctgatgcgt atgtgcaatt ctgctcgccg ctgctgcagc aagagctgcc acaatatcat 1751161 ccaaaaaggt gtgaataccg tctggacttt catcaagttc cttaataatt ccaatcttct 1751221 ctttatccaa ataaccgaaa ttggtcaaac cgatcgaccc gtacacatta acgattgaaa 1751281 gcgggataat ttcatctatg ccgtaaagcg gttcatccgt ttcaacaagg tgctgcagcg 1751341 gttcggggag aagtttctgt tctgcaagct gatcgagtgc aaggcctgtc aaaacagcat 1751401 gaataatttc acgtttgttc aggacttttt ctacattctc catgcaaaca ctgagcggca 1751461 gatttggatt gtatttttcc tgaagttttt gaacaatccg tgcaatatct tctatcataa 1751521 cgccccgttt gttcagcata tcctttgtta tatcgaccat ttcattcatt gtgtactttt 1751581 tcatgtctaa tggcatctcc tttaggcact catccagttg ggaggcgtgt tgcggtccca 1751641 gtaaatgctc ccaagctcat gatgtgattg aaatccatct tctgctgtat gataatgaaa 1751701 attaaaccag tagccgtcat gaggcgggtg gtctcttcgc acatggaatc tgagaagatc 1751761 ttctccagtt gtccgattgt aaacgttgaa aattttttcc gttttgcccg ctgaaggcat 1751821 gcttgagatc acaacatctt ggtacgcctc atcatcttgc aatgtcgcta aataatcact 1751881 aatcacattt tcgatttttg gcaggatctc tttccgatag tcatcctcaa tgacaggagc 1751941 gattctgctg ccgaatttta aaaaggactg atcctcagcg ctgtcaagga gctgttcctt 1752001 gtacgattga aaaagcagtt caggatctcg cctgtcatcc gactcatcat cgtacaggtc 1752061 atgctcatca taaaaagcgg tgtaatcatt ctgctcaaga ctgctcggct gtccggaagg 1752121 cttgtccgcc ataagggcag ccggaggaga tacgagcccg aacgttacaa tggtaaataa 1752181 aaccacaagg gtctttctca tccacaattt catgactgct tattcctctc tattttattg 1752241 tcatgtttct cttattttag cacatccaaa acatgcaagt catgtactat atgaaactga 1752301 tatgcaaatt aggagattcg ttgctatgca ctttgtgtaa aaacgcttac aatatttcat 1752361 gaaaggaggc tttccgcatg attgacgctc tgtttgccac agtttcactc ttaacattat 1752421 tatactttgt cgtcatggag gtcaccgatt aacagaaagc ccgtgatatg aatcacgggc 1752481 ttgtttgaat gacgccataa tggaacagtg ctgtttttct tttcatgacg ttaaaaccaa 1752541 actgttcaaa ccgcgggctt ttccagtggt cttttagcac aacgcttttt ctggcgactc 1752601 gtaccgcttc attgatacat ccttcgtgca aaacggaatc ctctgccaaa tcacgtaaag 1752661 gcgcgatgcc gtcagaggtt tctacaggtt catgaaacat tggatcgaaa taaaccacat 1752721 caacagagtt gtcagggagc tgcttgatgt gttcaaagca atcaccattc ttcacctgga 1752781 ttcttctcat cgcagcttga agctcttcta tacccgtttc ccatgaatgc agccccgtcc 1752841 tcactaaaac agacacaaga tggttttttt caatcccaac aacagaaccc gtttcgccta 1752901 ctgccatact tgcgataatg gcatctgacc ccaacccgag tgtgcaatct aaaaacgtat 1752961 ccccttcaga taagccggca gcccgaagca taggttcttt ctccccctgt aagaagcgtt 1753021 tggctctgaa catcgctgta ttcggatgaa aaaagaattt ggcaccttgt ttcgtataca 1753081 gctcaaaccg ctctttgccg accacaagca aatcacgttc agctgatttc agcaggtgct 1753141 caaccgtttg tttattccgg ccgcagtatg gcatatttag ctctttagaa agctgctttg 1753201 cagtttttat ggtgtgttca gacggtctat agcttgttgt tatcatcttc tgtactccca 1753261 aaaagaaaat gcccggagaa cgggcattta gcagtgcgca tcgaaggcag cagtcagatt 1753321 tttcatgatt tcttccatat cgtgtccttc aatttcatga cgcggaataa aatgtacgac 1753381 ttctttgcct ttcaaaagag ccattgatgg tgaagaaggc tcctggccag taaaatactc 1753441 acgcattttc gcagtagctt ctttatcttg gcccgcaaat acagtcaccg tattgtcagg 1753501 tgttttgtca ttctggagga ctgcctgtgt agccgcagga cgcgcaaggc ctgccgcgca 1753561 gccgcataca gagttaacga ctacaagagt tgtgccctct gccttttcca taaagttttc 1753621 tacttcttcc gctgttgtta actcttcaaa acctgctcca gtcagctcgc ggcgcatcgg 1753681 tacgacaagc tggcgcatgt attcttcata agccattgac ataaaaaaag ccccctctag 1753741 tatccttcat ctgaagtaaa ggatactata gagagggccg gatttcaaat gttcacgcct 1753801 taaaataaaa gaaagtgtcc ccagctatct agattttcat aataccgccg gtgttggcac 1753861 ttgtcacaag tttagaataa cgtgccaggt agccggtttt cactttcggt tcaaaacctt 1753921 tccagttcgc ttttcgtttt tcccactctt cttctggcac ttgtacatcc aagatgcgtt 1753981 tttcaatatc aacgataata tggtctccgt tttcaacaaa ggcaagcggc ccgccctcag 1754041 cggcctcagg tgatacgtgg ccgattgaga ggccacggga ggctccggaa aaacgtccgt 1754101 ccgtaatcaa tgccactttt ggcccgagtc ccattccaac gatttgggat gttggcgcca 1754161 gcatttccgg catgccaggt ccgccttttg gcccttcgta tctgatgatg acaacgtcgc 1754221 cttcttttac ttttcggttg ataatgccgt caagcgcctc gtcctgagaa tcgaatacga 1754281 cagccggccc ttcgtgtctt gtaatcccat tctgtacgcc gcctgtttta atgatagcgc 1754341 cgtccggagc tagattaccg aataaaacag caaggcctcc cttttcagtg aatggttgat 1754401 ccagcgggtg aatgacgtca taatccttta cttcatgtcc ggcaatggtt tctccaagag 1754461 tttttcctgt aacagtcagc gcatctaaat gaagcgctcc ttctttcttc gaaagctcat 1754521 tcagagccgc tgaaacgccg cccgcttcgt gaagatcttc aataaacaca tccgatgcag 1754581 gcgccagctt agccaagtgc ggcacgcgct cagcgacttc gttaatgcgt tctaaagagt 1754641 attcaacgcc ggcttcgttt gcaagggcaa gggtatgaag aacggtattt gtagaacctc 1754701 cgagcgccat atcgagtgca aacgcgttat caatcgcttt tactgtaaca atatcacgcg 1754761 gtttgatatc tttgcgaatc gtttccatta attgcgcagc cgattttctc acaaactctt 1754821 tgcgttccgg agatgttgcc agaatggttc cattacccgg caaagcaaga ccaagtgctt 1754881 ctgacagaca gttcattgag ttcgccgtaa acatgcctga gcaagacccg cacgttgggc 1754941 atccgaactg ctctagttct tgaagctcgt tttcgttgat tttccctgct tggtaggcgc 1755001 ctaccccttc gaatactgag gaaagggaga tttttcgccc gtcacttgtt cttcctgccg 1755061 ccatcggtcc gccgctgaca aaaatcgtcg gaatgttgat gcgcattgcc gccataagca 1755121 ttcccggtgt gattttgtcg cagttcggaa tacagaccat tccgtcaaac cagtgtgcgg 1755181 atacaaccgt ttccacagag tctgcgataa tttcacggct tggcagcgaa tatctcatac 1755241 cgatatgccc cattgcgatg ccatcatcta ccccaatggt attaaattca aacggaacgc 1755301 cccctgcttc tctgattgct tcttttacga ttttcccaaa ctcctgcaag tgaacatgac 1755361 cgggaacgat atcaatgtat gaattacaca ccgcaataaa cggcttgccg aaatcctctt 1755421 cttttacccc tgctgcacga agcaaactgc ggtgcggagc tctatcgatt ccttgtgtga 1755481 tcatattact gcgtaattct gccatggtga tcctcctaaa ttctttcaat tgtttgattg 1755541 gattttattt tgacaatttt cagtttattt atgggctgtt tttgcaaata agataaatac 1755601 aggccgccct caccttgttt tgttctttcg tgtttttata tttatatagc tttctttcga 1755661 tttgaaccct ccaactatta atattgttac ttactataaa tagttttcgg atatttttca 1755721 acaatattcg aaataatttt tataaaaagt gaattcacat aaaaaaggtg catgatctgc 1755781 acctttttta tctttattcg cctttttttc tgctttccgt catttgtttc caaacagaac 1755841 cttttgcttc ttctccatgc tcaatacgtt caagcgccat tttgacttga aggctgacct 1755901 caaattcggg gtcatcttcg gcagcgcgca aagcttcaat tgcactttca tcgccgactt 1755961 cgtacaggaa catggcggca cgccagcgaa caagcttgct ggagtcgctt aatgacttga 1756021 tcatagcagg aatggcttga ggatcgccga tatcagacag gcagtctccg gccgttcttc 1756081 tgactgatac agctttgtcc tcaagtgctt tatacaatag aggaagaaca tcaggtgttt 1756141 caatcattcc taagtacaca acagcctgtc ttctgatgga cacctttgga tcatccaatg 1756201 ccttctgtaa aaccgggata tcctcttctt tcggatccat ctgttccaag tgtgcataac 1756261 gctttttcca gtcctcatca tccagcatat caagcgttac tttatacgct ttgcgctgta 1756321 cagcttgttt tgcttcgccc tttccttgag cggctgcttc agtcagtcgt ttcagccgtt 1756381 catcactgta tgccgcttga agctcttctg tcacatcatg gccgatttca tcaaagtcac 1756441 cgaatctgac accttgttct ttccaagccc gctcaaacac aacattggaa gcttcagatc 1756501 taagttttaa gatcgcctgc tgaaagcgtt caggtaagcc gaagcgttct tcccgctctc 1756561 catcggttaa tttaacttgc ataggaatgc cgctgaacat ctgcacaaaa acttttacct 1756621 ctccaaaaga ttcttgatca gaacgatttt cttctgcgct ttcagcactt tccatcccaa 1756681 atgcagtgcg gacttgcggt aaaatgtctt tccagtcgta tcttgcattc cgttcaacag 1756741 caagaaaatc tgcgacgtga tatacccctt taactccatc tattttaagg atttccgcta 1756801 taacaagcgg tgcgccttct gcttgctcag gtttatagtt attgcttttg cccgccggaa 1756861 gctcttccgt taagatgact ttcattgtat tcgggcttgg tgtaggttca attgatttta 1756921 tcttcatgat cgtcctccta tagcatatct gtgacttatt ctatcatagt cgctccaagc 1756981 cttctattac gacgtttcgg catcaatccc gggtatgtct ttttctaatt ggcggacaaa 1757041 ttgaagcata aaattgtgtc tttcttctgc cagttcccgt gcagtgtctg tattcatcat 1757101 atctttcagc cgcagcagct tatgaaaaaa atgagcgtag gcgctttgct catctccata 1757161 aaggccatgc ccttttgcgc ccgcaaacat gaaagctctc gcaatgccga cagcaccaat 1757221 cgcatcaagt ctgtcagcat cctgtacagc ttttccttca attgagagcg gctccttcgc 1757281 caatttcccc ctgtcccgaa aggacatcct tgttataata tgaatcaccc tgtcagcatt 1757341 ctcttttcct actccgaaaa aaacgagctg atcatatact tcgctcacag aaagcctgac 1757401 cgtgtcaggc agcttcacat caattaaatc atgaaccaaa gccgccgttt caacaatgaa 1757461 caaatccgct ttttcctttt ctccaatata cgctgcaaga tctgctactc ttgatacatg 1757521 atgccagtca tgtccagagc tttcgtcagt caggatagat tgaacccatg tcctgatttg 1757581 ctctgcctgc ttcaattcct tcacaaaaac accctctttt tattgctcta atagcttcac 1757641 gatatcgtct tccaactctt tcggatttgt atttggtgaa taacggccaa cgatttctcc 1757701 atttctatcc actataaatt tcgtgaaatt ccacttgatc gccttagttc ccagcatccc 1757761 tttcgcatgt tctgtcaaat acacaaacag cgggtgggcg tttttcccgt ttacatccac 1757821 ttttgaaaac ataggaaatg taacaccgta atttgtttca caaaattcct gtatgtcagc 1757881 ctcttcacca ggctcttggt tcatgaattg attgcagggg aaccctaaga tctccagccc 1757941 ctcctgctga tatgtatcat ataattcctg cagctgcttc aattgggaag taaaaccgca 1758001 cttacttgct gtattcacga tcatcagtac ctttcccgcg aaaggctgaa gtgtcatgtc 1758061 tttccctgtg attgtacgta ccttcatatg ataaatagac atgtaagtcc ctcctatgtc 1758121 cttggtgctg attattttac cttttttaaa tcgcaattca aaatgtaaac atcaattaag 1758181 aactcataag aaacctaacg atatgagcgt cagttcatta tcaattcata tggctcgttt 1758241 tttatcttat cattctataa aacattacaa ttccctctta catctttgaa aatcatttta 1758301 ctgtgaaacc aaaaggcgtg tcagtgcgtt ttatttaaag agttttctgt tgtttccccc 1758361 tcaacacgta tagatagatt gaaaattggc gtgaaaattc ctataatgaa gaaaattaaa 1758421 cggggaaata atggaggtgg cacgttgcct attaatatac caacacacct gccggcaaaa 1758481 caggtgcttg aaagtgaaca tatatttgta atggatgaaa gcagagcatt tcatcaggat 1758541 atccggccgc aaaaaattat tatattaaat ttgatgccga aaaaaatcca aacagagact 1758601 cagcttctca gattgcttgg aaattcgcct ttacaggttc atttcacatt tttaatccca 1758661 agcacacaca cgccgaaaaa tactgcgaga gaacaccttg acgaatttta cacgactttt 1758721 tccaatatcc gtcacaagag gtttgacggc atgattatca ccggtgcgcc gatcgagcat 1758781 ttggcgtttg aagaggtttc atattgggaa gagctcaagg aaatcatgga gtggagcaaa 1758841 acaaatgtca cttcaacctt gcatatttgc tggggtgctc aagcaggttt gtattaccat 1758901 tacggtgtgg aaaaaattca aatgccgaaa aaaatcttcg gtgtgttcga acataccgtt 1758961 ctttcaaaac acgaaagatt ggtaagaggt tttgacgagc tatactacgt gccgcattcc 1759021 cggcatacag atataaatat ggaacagctt caagcagtgc ccgagttaaa cattcttacc 1759081 gcatcaaagg aagccggggt ttgcttaatt gtgtctaaag acgaaaaaca agtctttttg 1759141 acagggcacc ctgaatatga tacaaatacg cttcttcaag agtatgaaag agatttggaa 1759201 cgaaaccttt ctactgtcga ggcccctaaa cattattttg caaaaggcag caacgagcca 1759261 gtgaatcgct ggaaagcgca tgccacatta ttgtttatga attggctgaa ttattacgtt 1759321 taccaagaaa ctccttatga atgggactaa tttttctttt tttagtgata cgctgagcaa 1759381 aaaatatgat aaaatacatc tgattcagtc tgcgtataac aaaaatttaa aatactggaa 1759441 tccaaatcat ttaaaattag cttaactttt tcactgcatt aataattcga ttatgtattt 1759501 gtgttatgtt tatgtataga caataactcc ttacgatgca tgaagcttgc ttgttgttga 1759561 ttacattgag gtgaatttac ttgaatacca ataaaagagt attaattttg actgcaaatt 1759621 acggaaatgg acatgtgcag gtagccaaaa cactttatga acaatgtgta cggctcggct 1759681 ttcagcatgt aacagtttct aatttgtacc aagagtcaaa tccgattgtt tcagaggtaa 1759741 ctcaatacct ttatttaaaa agcttctcaa tcgggaaaca gttttatcgt ttgttttatt 1759801 acggagttga caaaatctat aataaacgta aattcaatat ttactttaaa atgggtaata 1759861 aaagattggg cgaacttgtc gatgaacatc agcccgatat tattattaat acatttccga 1759921 tgatcgtcgt gccggaatac agacgccgaa ctggaagagt cattcctacc ttcaacgtta 1759981 tgactgattt ttgtcttcat aaaatttggg ttcacgaaaa cgtggataaa tattatgtgg 1760041 cgacagatta cgtgaaggaa aaactgctgg agatcggcac tcatccaagc aatgtaaaaa 1760101 tcacaggaat tccaatcagg ccgcaatttg aagaatccat gcctgttggc ccgatatata 1760161 aaaagtacaa tctttcacca aacaaaaaag tgcttctgat catggcaggt gctcacggtg 1760221 tattaaagaa cgtaaaagag ctgtgcgaaa accttgtcaa ggatgaccaa gtgcaagtag 1760281 ttgtcgtgtg cgggaaaaat acggctttaa aagaatcttt gagtgcgctt gaagcggaaa 1760341 atggtgacaa attaaaagtt ctgggctatg tggagcgcat tgatgagcta tttcggatca 1760401 cagattgcat gattaccaag cccggcggca ttactttgac agaagccaca gccattggag 1760461 tgcctgtcat tctgtacaaa cccgtgcctg gccaggaaaa agaaaatgca aacttctttg 1760521 aagaccgcgg agctgccatc gttgtgaacc gtcatgaaga gattctcgag tcagtcactt 1760581 cccttcttgc agatgaagat accttgcatc gcatgaagaa aaacattaag gaccttcatt 1760641 tagcaaactc ctctgaagtg attttagagg atatcctgaa ggaatcagaa atgatgaccg 1760701 ccaaacaaaa agccaaagtg ctatcgtaat ggcgtacttg agagcatacg aaaatcgtgt 1760761 gctcttttta tttatattca gccatcaata aaagcggtta cattttttta tggaacttgc 1760821 ccttcttttg aaaaataagc cgtttcgcaa cttgacgggt gctcccagat ggtgtatagt 1760881 tgaaccatca tttaacaatg aatcaaagtt agatgatgac aaaatttttt ttagcacatg 1760941 ggtgctacag tactaggagg aattaagcaa tatgcaaaac ggtaaagtaa aatggttcaa 1761001 caacgaaaaa ggattcggct tcattgaagt tgaaggcgga gacgatgtat ttgttcactt 1761061 cacagctatc gaaggagatg gatacaaatc attagaagaa ggacaagaag tttcttttga 1761121 aattgtcgaa ggtaatcgtg gacctcaagc ttctaatgtt gtaaaactct aaactcaata 1761181 catgatgatg agatgacaaa tagaggagag gcattcgcct ctcctatttg attttcatct 1761241 ggatttcaat cgccaaaatg ttttgtttac acctctgttc aatctcttca acatactttt 1761301 ccattgatgg ttttcctttt ttcgcgatat cggccagttc ttctaaatca ctgtatattt 1761361 ctataaatgt tttgtgaagg atcaacttca agtctttatc atccatagct gcgttcccct 1761421 tctctatcaa gatacctcaa atagtaaaac ggtcctattt attctggttc aatagttata 1761481 tcggcttatt tttattttct tttctatttt ggtacataaa tttcaaaaaa actctgcaaa 1761541 ataatggcgg aggtgttttt tgtgacttca gaatttcata atgaggatca gaccggcttt 1761601 acggataagc ggcagctgga actagcggtg gaaacagcgc agaaaacaac aggagccgcg 1761661 acgagaggcc aaagcaaaac attagtcgac tctgcatacc aagccattga ggatgctaga 1761721 gaactgtcac aatctgaaga gctggcagct ctcgatgatc ctgaatttgt aaagcagcaa 1761781 cagcagctgc tagatgacag cgagcatcag ctggatgaat tcaaagaata aaaaccgcag 1761841 cttctgcggt ttttattttt agtgattggt taagacatct ccgtattgtt tcaacttttc 1761901 accaaccgta catttattga tacaaaatga atgcgcataa gttttgccaa attctttgcg 1761961 aaactgcttc ttaataaaac agtccttgca atattcatcg tgcagttctg tcagttcttt 1762021 aaagatcatt ttcttatcca atatcgtcat ctccgttacg gtctaatttc gtgtggcttt 1762081 ctacgaattg atgggataga atttttttag cgaggccgtc agcttcctga ttgtcttttc 1762141 gttgtattgt ttcgtaggtt ggagtaagct tcagcgattc aaggagtgct tctattttgt 1762201 ccagccattc attatgagat ggatcataac aaggccagct gccgtcaagc tgattcagca 1762261 caacaagcga gtcccctttg attgtaattg aatttctgct tgccccaagc tctcttactt 1762321 ctcttattgc ttcataaagc gctgcgtatt cagcttcatt attggttttc agccggaagc 1762381 ttttattttt tctcaagcga tgccgggttc ctcccaatga ataatagatg acgatcccga 1762441 gaccggccag ttcgctctct ttatcgaaac tgccgtcaaa ataaacagta atgtcatcag 1762501 gctcttgagc aagctcctct gtcagctttt ccaattcctt cagcgtccag ctgccgcctt 1762561 tctcgtcttc gaactctagc tccttcatgt atggaaaacg gccaagttct ctggcgaacg 1762621 tacgtgcctg ctgtgctgtc agccagtctt cgctaaaaaa tgagacggat cccgttcctt 1762681 ttgcttctat tttcaaatgc ggtctgagct tcattacaat caccttacca ttcattagtt 1762741 gccgggctta tgctataatc aaaccaatct taccccggaa aggaagcttt ttcatcttgt 1762801 ttaataattc gttttggatc ttttttgcga tcattcattt tatcattgtt cttttatttt 1762861 ataaaggatt tggcaaaatg ggactgtttg tttggatcgg ttttgcgaca gtctgcgcca 1762921 acctccaagt cgtcaaaaca gtcgaactgt ttggcttaac agcgacactc gggaatgtga 1762981 tgtatggcac aatctttttt gcgacagatg tgctgaatga aaaatacgga ccagctgaag 1763041 ccagaaaagc ggtatggctc ggattctcaa cgctcctgac gctgacattt gtcatgcagg 1763101 gcgtgctgct tttcgaaccg gcttccagcg acatatcaca aacagcgctg gaaacgatct 1763161 tcggattcct tccgcgagtt gcgttaggaa gtctgcttgc ctttatcttc agccaaacgc 1763221 tggatgttta tgtatattcg gcaattagaa ggatatttcc ttctgatcgg cttttatggc 1763281 tcagaaacgg cggcagtaca gcagtcagcc agttgtttga tacattcata ttcactgcag 1763341 tcgcctttct cggcatttat ccggcagacg tgtggcttca tatttttatt tctacatatt 1763401 tgattaagtt tgcggtatct ttaatttcat tgccttatgc ctatgcagcc aaaaaaatga 1763461 tacctaatga tgaaaggagt tcataatgcc tacagaaata tatgtagacg gcgcaagcgc 1763521 cggtaatcca gggccttccg gtatcggcat ttttatcaaa catgagggaa aagcagaatc 1763581 tttctctatt ccaatcggag tgcatacaaa ccaggaagcg gaatttcttg cattaattga 1763641 agggatgaag ctatgtgcaa cgcgcgggta tcaatcagtt tcctttcgaa ccgattcaga 1763701 tattgtggaa cgcgccactg agcttgaaat ggttaaaaat ataacgtttc aaccgtttgt 1763761 agaagagatc atccgattaa aagcggcatt ccctcttttt ttcatcaaat ggataccggg 1763821 caagcaaaac caaaaagccg atcttctggc aaaagaagcg attcggctga atgaaaagaa 1763881 ttaaatcttg atcattggtt catcctaatg gcgaggtgaa ctaacatgaa aaagaaagat 1763941 aaaggccggc tgaccggcgg tgttactccg caaggcgacc tggaaggcaa tacacataat 1764001 gaccctaaaa cagagcttga ggagagagca aaaaaaagca atacaaaacg ctagagagga 1764061 tctaaacgat ctctctagcg ttcagctttt caagcatacg ctcaattcct ttaatttggt 1764121 ggcggcgaag catgtcagcc gcctgctcca tttgcaaagt aaataaagcg tctttcagtg 1764181 tgcaggccag cggcactgag caatggattt ccgcaagctt cctcgacatc tccaaatcgc 1764241 ttaaaccttg ctgaattttt ccctgctgtc cttttggaag aagagaaaga ttttccaata 1764301 aacggtcaat cgtttcgtat tcacgaatca gtttgtaggc tgttttttct ccaatgcctt 1764361 tgactccggg atagttatca ctggaatcac ccataagcgc tttaatatca atcaaagcct 1764421 tcggcattac gcctgtttct tcataaaaag tctcttttgt atagacttta taatttccga 1764481 ttcctttttg aagcaaagca acgcttactt tatccgttaa cagctgaagt aaatctctgt 1764541 cccctgttac caccgtaatg tccgcttcat tcgcaaataa atcggcaaga gtaccgatac 1764601 agtcatccgc ttcatagccg gcaaagccaa tattcatgat tccaagctct gcggctgctt 1764661 cctttgccaa atcaaactgc ggaatcagct ccacaggcgg cgcgctgcgg ttggccttat 1764721 aatcttggaa caagtcattt cggtacgttt tgctccccat gtcccagcag cagacgacgt 1764781 gtgtcggctg gaatgtttcc acagctgtaa tcaaatgctt taaaaagccg ttgacgccgt 1764841 tcgtcggcac cccgctgtca tttatcataa agttgcgatg tacggccgtg gcaaaaaagg 1764901 cccggaataa aagagccatg ccgtcaacca gcaatagttt attattattc atcaaataac 1764961 tcccttttct ttcattcctt ctattttatc ataaagcagc ccaaaaataa aaaacagtat 1765021 ctctttaatt agagatactg tttgaatatt tatcaatcgt tgtgtctttt gttgctggcg 1765081 atcagctttt cagcttcgcg tcctgcgtaa gagtcaaaat gggtttgaaa tccgtttttc 1765141 tttttggcgt tgttattcgc ctgtgcattt ctgtttccga gctttgttct gcccaacatg 1765201 aatcccccct tacgtcggat gcatatagta tatgcttccg gcaggaggtt cactcgcgac 1765261 aggatcatcc agcttacatg cggcttacgt attctctgac catttctttt gatacaagcc 1765321 gtcttgtcgg gacgatgcct tttttagcga gctgattcat ttgctcggta atttcattaa 1765381 ttgcatctgt agtataaggc tcatcgtttc tgcatttagc aacagcttct tcaatcgcca 1765441 attcacgcat attttcaaga cgcataaatg ctttgatatg ctcgtgctgt tttgatgaat 1765501 gtgctgaaat tgctttatgt acctctgaca ttaatcgttc atctcgcttt tttctattta 1765561 gtctatcatg acttgaaata caagccaact gaattttaca tttttattgt attgtctgaa 1765621 tttttccagg agatgcacgc ctgatacgcc atttcaatct ctttcgcatg ttccccttcc 1765681 gcatatcctc ttaaatatgt ctctttttga tccgttattt gcgcgattgc tttttcaccc 1765741 atatcttcct gtaagcgtct gaggtgagca gtgtaatgag atatcaggct ttcttcttca 1765801 ttttttatcc atgcctctgt gattttcgta agtttcatcc gtacagcttc gataaaggtc 1765861 gcttttcctt tctgctcaaa aaactgcttc ggtgatttga tctcttttag ttcctgctca 1765921 aaagcacgtt cttctatttc cggttcaact tccttcaact gtatgccgtt cgaatgctga 1765981 tcacccgcat aaacggaaaa ataaccgtcc tcgtttaatg ttttttgaaa atgatccagc 1766041 cattcttcat tgatatgccg ttcgatgaaa ccgctcatgc gaacatcaag cgttttgatt 1766101 tcctgaatat attcaaatag atattcatgt aaggctgttg tcatcgcttt actgacgttc 1766161 tttttccaat ccccgttttg cagcccggga tgaaatgccg attttaataa atcatttgca 1766221 aaatatgata atcgctgtgc aatgtgatat agctgctctc ttgtatcttt ttttactttt 1766281 tcaatgatgg tttttgagtt ccgccgtttc tcgatatcgg ccgctgtccg ctcaaatgac 1766341 agcataaggc actgtttctg cgcttccttc tcttctcggg actgatgctg ggattggtga 1766401 agctgaaaaa cagtttcgca tagtttgtct gcctccgaac tgagctgcgc tgctgacgct 1766461 ttttttacat ccacttcgat aaaccggtct aagtgttttc ttactttcga gaactgatta 1766521 taaaatgact ccggttttcc caccagttcc tccttacttg atacggtaaa gagctgcggc 1766581 tcataaaccc cttcttttac aagctctgcg ctgacataat cggtcactgt ttcgagctct 1766641 gttttatctt ttgcaaggtc tgcagcatta ataataaaaa acattttatc catgctgagc 1766701 gattctttca caagtccaag ctttcgcaaa aatgaacggt ctccttttga aaaagagtgc 1766761 tgataataag tcatataaaa aaatgcatca gcatctttga tatattggaa tgccagttct 1766821 gtatgccgtt tattcatgct gctcgcgccg ggtgtatcaa cgatcgtaat ccctttttca 1766881 gtgagcgggc atgtatagta gaccgttacc tctttcacag cacaggccgt tgtttcctct 1766941 gctacatacg gctttaattc agagagcgga atcgttaatt tcttctgttc ctgtatatac 1767001 tgctgatact tctcgtatgc aagcaggaaa ttgctgatca atttcacgtg ttcttcctgc 1767061 agcctgtttt ttttgactgc cttttcccac ttctctgtga aggaacggcc tgccggctcc 1767121 tttggtattc cggtgagctg caaaatttca gccgttaagt catcctctgt cttaaacact 1767181 acattcgctg ttttgtttaa gttgccattg attggctttg tgatcttgtt aattgtcgct 1767241 gtggttggcg ttggtgagga tggcagcact ctttcgccga caagcgcatt ggcaaatgat 1767301 gatttccccg agctaaagcc tccaaaaaga gcgagtgtaa atttccgttc ctcaagcctt 1767361 ttcacccttt cacgaaacgc tgaagtttgc tttaacaaca tgctgcattc gcctaaaatg 1767421 tcagacaaag tgtaaaagcg tttgatttgg tcttgaagcg gcatttcttg ttccattttg 1767481 atttctgatt tcggcatcgg ctgcgccgtc agctggcttc ggccttgttt ctgctctgga 1767541 gccgccactc ttgttttctt cgatttaaac cattctgtgt ctatatgcat tgggcatgcg 1767601 gactcttctt cccaaatggc ccacaggcga tcggttttct ctcgggcatt attctctaaa 1767661 cgtgcctgtt cttgaagaaa gacaagtttt tctgattctt ggacgagccg gtcgttaatt 1767721 gtttgcacat ctttggaaac acgctctttc accatagcgg agagcacctt tatgatgtct 1767781 gcggcttctc ttttcgcctc tttccggatg agctctgcca agtcttttgt atattgcaat 1767841 acatattcag aggaaaaggc tgcaccatgc ttgaccgcgt gttcaatgat gcttatatca 1767901 agcggtgtgc gataggcctg aatcagcttt tcactttcag cggtatagac atcaaatacc 1767961 ttggcgagtt tatgaagcgt gtctatcata tgccaatccg cttcggcctc tgttcgtttt 1768021 gccacatcag agaaaaaagc attccgcctt ttatctcttt cctgtgcagt tttcgcttta 1768081 gaaaagaaaa agccggtttt aaaggaaggc tcttgtgatt ctaaaaatgc agccgccaat 1768141 tcacgcattt caaaaggcgt caggttggcg ttttttaaaa tacgattgat ttcttcctgc 1768201 atcctcttct ctgcctcagt catttgtttt tcggcctcat ccaattgatc acgcagcgat 1768261 tggaccagtc cagtatggat attaagctgt tcagcgaaac tcggagcgcc tgtttcgtct 1768321 ttcttcagca tttccgtatg ttcctttagc agattacgga ctttttgttc ggttaaagcc 1768381 tgcatattgc tttttgattg ctgttctatt ctgcttaact cttctctcag ggcccccatc 1768441 tgattgaacg ggtgatccgg ttctgttact gatgtaaaat agagcgcttc ccttgaaatc 1768501 ccttcattgc aaagcatctc ctctacctgc gcttgatagt ctccaaattt cgtctccgtc 1768561 tcatcatggc ggtcaatttg attgacgata aaatacacat tcggaatgct ttcttttatt 1768621 gatctgagaa actttacatt ttcctcagcg tgcacgtgat tatagtgaac gacgtaaaac 1768681 agcgcatccg cttggtgaag aatagaagca gccgatagaa aatgcgcatc atctgttgaa 1768741 tctatccctg gagtatcaat atacgcaacc ccggaatcga tctcagtata cctgtcaaaa 1768801 atttcgacgc tttcaatctg ttccccgtct ttacaatatt gctgcacctt gtctttctgg 1768861 taagtccctt ccagctcagc acacgctccg tctgttgtat gaagccgaac tcgcttttcc 1768921 ccgtttctga tcacaacaag gttagcgctt gtcggaatcg ggcttgtcgg caaaatattc 1768981 tccattaaca ggcagttcag cagtgacgat ttccccgctg aataatgccc ggtaaacgcg 1769041 atataaacct cttcatcagc cgcttttttc atgaccgcag ccagtttagc agccctttgt 1769101 tcatcttgat tctcaataaa ttgcttataa agttccccgg ttttatgcaa aagctctttt 1769161 ctgttttgat ctgtcataag tctgaacccc tttgtgccgt ttcaattgtg aacctttttc 1769221 gaaagatctg aattcattcc cttttcattt tacacaagaa taaaccaaat ttctttagga 1769281 gaatagaaaa aagccgccat tacggcagct tctataaaag aaaatctgca acttttacaa 1769341 gttccagatt catcaaacag atttattaga gattcctttt aatacaaaac caattaatac 1769401 actatatgta caaaccgctc caagcaaaaa cagcattgtc atttgcttca ccatcctgat 1769461 tgagaatctt tttcaaaccc attttaacat ggttgagaat gattttcaat cgctatttta 1769521 cgctgtattc ctgtaatgct ttgtcttctg cgcgaattct gacgcttaac aacacggcat 1769581 tgaaaatgga aaacagacac atggtgacgt atgcttgata aagcagcgga atcagcaaaa 1769641 tttcgaggat aacaacggca tagtttggat gtttcatcca tttatatgga ccttttttta 1769701 caagctctac acctggaaca acaaggattt tcgtattcca atatgctcct aaggaacaaa 1769761 gcgcccaata ccgtacgatc tgtacgctta aaatcactgc agcgataccg agccaccagc 1769821 tggacggctg tttattcatc agcagcacct cggcaattaa ggacaggaaa aaaaggatat 1769881 gcatcgtaat gatatacgga tagtggctct cgccaaattc aattgctcct tgcttcttta 1769941 ccttttgttc gttttgcctg gccactgcca tttctgctgc tctttgaaca atgagaatgg 1770001 cgatcaacaa ccaaaacatg agtcaggccc ccttttccca gctgaataat agcaactctg 1770061 atgagaaacc cggccctaat gcgccaatca gtcctcgttc agcttccttt ttatgtccgt 1770121 tctgcagatg gtctttgatc acatacaaga ttgtggctga agacatattt ccgtgctttt 1770181 gcaaaatgct ttgcgcagat gaaagctttt ctgacgacag cccgagactt ttgatgtatg 1770241 catcgatcac tttttttccg cctggatgcg ccaaaaaaac actgatatca tggaatgaca 1770301 gcttatgttt gtccaaaaaa atctgtacat ttgttttgag ccatttttcc accaaggtcg 1770361 gaatgtctcg tgagaaaatg actttgaatc cttgatcggt aaagtcccag cccatgacat 1770421 cttctgattg tttcatcaaa acagattggg cgtccattat cttcggcgca agcttcagct 1770481 ttgacaccct gcggtccgcc ttctctccgc ataataaagc tgcggcaatg ccgtcaccaa 1770541 aaagcgaggt gccgatcaga ttgctttttg ttttatcttc cggctggaat gtcaggctgc 1770601 acagctcggc agaaatgaca agcacaaaag cctcaggata cgctttgcag tattcggctg 1770661 cacgcgcaag tccgctggct cctcctgcac agccaagccc ccaaatcgga atccgcttcg 1770721 tatatggaga aaacggaagt tcattcataa gccgcgcctc gatactcggt gtggaaagac 1770781 ctgtactgga gacgaaaaaa acagcttcca ctttctcata aggaatggct tcttgaaaaa 1770841 attccggatg agagaggcac tcacgaacag ccgctctgct gtgtttaagt gtttcttcta 1770901 tgtatatttg atttttttct tcaaagctgt gcccctcttt ataccattca atcggcttaa 1770961 caaactgtct cgaatggatt tgcccgtttt taaaggagga taacagcctg tcaatatcct 1771021 taaaagaatg ctgaaacata tagcgggcga actcggccgc tttctcttgg tttacattat 1771081 acgcaggaag acttgttcca atggataaaa taaacgccat gcgatcacct ctttgcatac 1771141 attgtgccgc aacaatcttt tttatatgca aaaaaaactc cgccgcggcg gagttagact 1771201 gctgtttttt gttcagcgag gtcagcttct tgttctattt ttttagcttt agaaaaaacg 1771261 ttatatacaa tatttaagac gactgcagta aagctgcccg ccacaatgcc attcgttgta 1771321 agcagcgtta aggcactcgg aagctgtttg aaaatatccg gcacaacggt cacaccgagc 1771381 cccaatccca ctgagcaagc aacaatcagc agattttcct gtttcgcaaa atcaatgcgg 1771441 ctgagcattt taattccgta agcaatcacc attccaaaca tcgccaccat tgcaccgccc 1771501 aaaacagcgg atggaataat agtcgtgaaa gcagcgatct ttggaaacag cccaaatgcc 1771561 attaggatca cacctgtgac cacaatgacg gcattttttt tgatccctgt gagctgaaca 1771621 agcccgacat tttgagagaa tgccgtgtaa ggaaaagcgt taaaaatacc gcccagaagc 1771681 acagccagtc cttcagctcg atagccttta gacaaatcta tctctgtcaa acggcggttt 1771741 gtcaggtcac ctaaagcaaa gtaaacacca gttgactcca caaggctgac aattgcaacg 1771801 atggacatcg taatgatagg cgctgcgtga aaagacggcg ctccgaagta aaatggctga 1771861 atcatttgaa caactgccgc gtccgaaaca ttatcaaatt gaacttttcc cataaaatat 1771921 gcgatgaagg tgccaatcaa aataccgatc aaaatcgaga cggacttgat aaagcctttt 1771981 gtaaaacggt atagaagcac aatgatactc aacacggtaa aagcaagtgc aagattggag 1772041 agatctccga aatctgcact tccttctccg ccggccatgt tattcatggc aaccggcatc 1772101 agtgtaatac cgataatcgt aacaacagag cctgtcacga ccggcggaaa aaacgatacg 1772161 agctttccaa agaaaaatga aataagaatg acaagaatgc ctgaagcgat aatgctgccg 1772221 taaactgttg aaaccccata ttcagatcca atcgctatca tcggcgatac agctgtaaag 1772281 gtacagccaa gcactaccgg aagcccgatc ccaaaaaatc ggttgctcca cacttgcaga 1772341 agtgtagcca caccgcacat aaaaatatca atcgatacta agtaagtcag ctgctcgaca 1772401 gtcagtccca ttgcttttcc gacaatcaga ggaacgacaa tggcgccggc atacatggca 1772461 agaacatgct gaatccctaa agacagcgtt ttgccgaatc catttctcat gaatgaacct 1772521 cctgtacgaa ggacactttt ccttcttcta aagactgaat tcttgccaaa gattccactc 1772581 ggtagcccag ttttacaagt tcatctcttc ccggctgaaa tgacttttca ataacaatgc 1772641 cgattcccgc aatagaagct cccgcttgct tcacaatcga cacaagcccg tgcgctgcct 1772701 gtccatttgc caaaaaatca tcgataatca gcacatgatc ctgatccgac aggtgggtcc 1772761 cagacactgc gatttggctt tctgtttgct tcgtaaagga ataaacagac gctgtcagca 1772821 agttgtcggt gagtgttaac gatttatgct ttctcgcgaa gacaactggc acacccagct 1772881 tcaagcccgt cattacagcg ggagcgatac ctgatgattc gattgtcaca attttggtaa 1772941 taccgtcttt tgcaaaccta gacgcaaatt catcaccaat tctctgcata agcagcggat 1773001 caatttggtg attcaaaaaa gaatccactt tcaatacctg atcagataat acgacgcctt 1773061 cttcctctat tttccgtttc agtgcttcca tcctgtctac ctccgttatg agaataaaaa 1773121 aagcattgcc cgctcaaata aagagcaagc aatgctgata tcacaaaaaa ccgtacacgt 1773181 gcggttccat tgctcaccca tagtcggaca tttacggtgc ccggtagaaa cttgcgtgcc 1773241 atatccacgc gattatatga gtgttcctat tatattgtaa taaattatat caagattcta 1773301 atctcttgca taggctgaaa ataaaaattc ccgaacttta attttgtttt tttagatatc 1773361 attcgtattt caaggggatt cgatataaaa gagtctgacg accgcgccgc caggcttttg 1773421 attataacag atagagattt gaatatttgt ttgataaata atcaattaaa tagcgaacat 1773481 tcagctcttc tcctgttgca tctttaataa tgtctaacgg ctttttccgt tttccgtgaa 1773541 tgtgcacctt ttccgtcagc cattgcttta tcggatggaa ctctcctctt tccaagagag 1773601 cgtcaaattc agggagatcc tcaagcattt tttgtttcag ctgagccgca tacatgtagc 1773661 cgagcgcata ggatgggaag tagccgaaat ctccacctgc ccaatggacg tcctgtaaaa 1773721 tcccctctgc gtcggtctgc ggtgtaatcc ctaaataatc ctggtatttt tgattccaaa 1773781 gcgacggcag atcttccaca gacacttcat tgctgaaaat cgctttttca atttcataac 1773841 ggatgatgat atgaagagga tacgtcaatt catccgcttc gaccctgata aatgaaggtt 1773901 ttgattcatt gattgcccgg acaaaatcat ccagggagat gtccttgaac tgtacaggtg 1773961 atgcctcttg aatcttctta tagtacggag tccaaaaatg cttgttgcgg ccgataaaat 1774021 tctcgtaaaa taatgattgc gattcatgaa ttcccatcga tgcgccgtct gacaagttcg 1774081 tgccactgag tgcttcatca atattttgct cgtaaatcgc gtgcccgcac tcatgaatgg 1774141 tcccaaagat cgccgtccgg aaatcttttt catcatatct cgtcgtgacc cgaacgtctc 1774201 cccgattcag cgtagttgca aacggatgaa cggtttcatc aagtcttccg ccatcaaaat 1774261 cgtagccaag ctcctgtaaa aaatacagac tgagctcttt ttgcttttct ttcgggaacg 1774321 cttttgtaat aaagcttgta tctggtttat ttccggaagc tgtcacctgt ttaacaagag 1774381 ggataatcgc ttccttcagc tcagcaaaca actgatcaag cacctttacc gtgacgccgg 1774441 gctcaaacaa atcaagcaat gcatcataag gatgctcttg atatccccaa tacgtaataa 1774501 aacgtttatt gaattcaatc agctgttcta aataaggaga aaacaagctg aaatcagatt 1774561 ttcctttcgc ttcctcccac gctgtttctg cctttgaaca cagaatcacg tattctttgt 1774621 attcagcctc agggattttc ttattctctt catactcttt tttcgccagt tccactgctt 1774681 ttttcgtatc ttccgacaag tcatcaaatc gttcatacag gacatcgata agctccttca 1774741 ttcgatctga tgtttggata ttgaatatat ctgttgaaag ctggccgata ctttcggcac 1774801 gatcctctga gccatttttc ggcgcgcctg ttctggagtc ccagtgcatt aacgcaactg 1774861 cttcgctgta atgtgagatt ctttttaaaa gatcaaaaaa ttctttttca tatgtatgta 1774921 tctccatatc cattccctcc ctattctagc cgttccatta caggctaatg gaagggggta 1774981 tgaaagtcaa attgtttgta taaaaggctg ccggtatgtt ttgtggcagc ctttttattc 1775041 agttgatcgt catttgattt tttggcggag gtgttctccg ctttttctgc ttgatttttt 1775101 tatctaccca cactgttgcc agcggggtta agagcgaggt gacaataacg cttgtcgcga 1775161 taattgcagt tgccgactca gcaactggcg caaatgaggc attcgcttcc gctaatgcat 1775221 atggcacggc tacagccgcc cctgccgtag aagaagcggc cactcccgcg acaccatctc 1775281 cccgcgcaat aaaacgatca agcaaaaaca aagaactgcc cgataaaatg acgacagaaa 1775341 ctccgataaa aatgccgagc agccctgatt ggatcagcat tccaaaattc aaggtattgc 1775401 cgagcgaaaa ggcgaaaaat ggaatgatcg ccggcacaac cttgctgaat aagtctctga 1775461 gatcatgatc cagatttcca agtatacatc caagtaaaaa cgggatgact gtcgctgcca 1775521 gcgtttccca tgggaatgcg gcaagtcccg tcacaccaaa cgtcaccatg gtcataaaag 1775581 gaccagattc tgtactgata aaggcgaaag cgcccgcatc ctcttttctt cccatgtgat 1775641 tcatgagcgc caaatacagt ccgccgttcg tttcattcat taccgcgaca attgctaaaa 1775701 cagaaaggcc tgcaaaaaag ccggattgta tgccatcgtc aggtataaat tgcgctgcga 1775761 tcacgccgag cagcgccgca aatccgatct tccccaataa taacgtgatt ccttttcttg 1775821 cgatatagcc tgaagaacga aaatcaatcg ttgctcctac gcaaaagata aaaacaccca 1775881 gtatcggcag cgttccggta atcaaagcac ccgtaaaccc tccaaagaac tccgctgttc 1775941 caggcgcaaa cgtgttgagc gccgctccaa gaaatagcgg aataatcatc attccgccag 1776001 gtacccgttc aattgtcgcc ttgattttca tattgtggat tctcccatcc tccggttatg 1776061 aaaaaacaat tccacttaca cttggaaaac agcctgcaaa tcctcttttg aacagctgcc 1776121 caactggctg ccgactccga cggcgccagc tccggctcta agccaatcag gcacttcaga 1776181 cggatgtatc ccgcctgtcg gaataaaggt cacctgcggg aaaggacccg ctaaattttt 1776241 cataaacgga atgccaaaca caccgcttgg gaacagcttt aatgtcgtaa aaccgaatgt 1776301 cagcgcttcc ataatttcgc tcggagtcaa gacgccgggg atataatgtg tctttacaaa 1776361 agatagatgt tcagcaagat cagctgaaaa acccggactg acaataaact gcgcgccagc 1776421 cttagcagct tccccagctt gctgcgcgct gatgaccgta cccgcgccaa ttaaaatatc 1776481 ttccctatta cggaaggatt cgataatatc tgatgccccg ggggtcgtat acgtcacttc 1776541 aactgcacga atccctttat ctaataaact ctcaatctgc tgacaggcct cctgcttatc 1776601 ctttgaacga atgactgcaa tcagctttgc ttctttcaga cggttttcaa cgactttgga 1776661 ctccatatta ataatcccct ttcttttggt gaaccgttct ttgagcagat aaaaaagaag 1776721 ctaatttctc cctggtcggc aaaccgtcca tatcccccgg tgcctgcact tgcaaagcgc 1776781 caatcgcatt tcccctttgc accgcatcct tgtacgacaa accgtctagg ataccgctga 1776841 ttacaccgac tgcaaatccg tctccggcgc cgaccgtatc aaccacccgg tcgacccggc 1776901 agccttctag aaatccttca cttgtccccg ttttaaagta agcgccttct tttccaagtt 1776961 taatagcaac aaagctggca ccttttttca aataatagtc ggcaatgcct tcaggtgttt 1777021 tttctccggt caatagctct ccctctgcga tacccgggaa aaaccagtct gcaagcccag 1777081 ccagatcatt gattgtgtgt accattgttg cttgatcagg ccaaagcgaa ggtcttacat 1777141 tagggtcgaa tgaaatggtc ttccctgcgt ttctcatgtc gttcatgaca tgatacgtga 1777201 agtctttcat ctcggctgat aaagcaggcg gaatacctgt cacatgcaaa tggcctgcgc 1777261 attgaaaata atctctcgga tattcagctg tagttaatgt gcttgcagct gagtttttcc 1777321 tatagtaggt aacttgcggg tcgccttctt tcacttttga cttcagcagc agcccggtgg 1777381 gattttcgtc ctgcgagcgg atcacgcggg acacatccac tccctctttt ttaagctctt 1777441 gtaaaataaa cgttccgagc tgatcattgc cgaccttgct catccatccc attcgaaatc 1777501 cgagtctggc aaggccgcag gcgacattgc tttctgctcc ggcaagccct ttagaaaaag 1777561 tggatacttc atgaaggcct ccatactcat ttgcataaaa catggccatt gattccccga 1777621 atgtcaccgc atcaagcttc atctcttccc aacctcctct tagttgaggg cacctaggat 1777681 taaagtgact ttctcatgat gacttttgcc tctaattcaa tggtttgagg cgctcctttg 1777741 tcaccttcaa tcctttttaa tacacgttcc atcgccgtcc tgcccatatc atgtgacggc 1777801 tgggcgatcg ttgtaatgcc tggaccgatc agtttgtacc actccgtatc atcgaatcct 1777861 gcaatcccta tatcttgagg gatgcgcagg ccaagctctt ccatacagct gatgattttc 1777921 agcataatca agccattcaa agccagaatc gctttttttt gctccggcat ttccttgtga 1777981 aaagaacgaa gctccgcctt aagctgctcc ttgtccttta cgtcaatttc atgcaatctg 1778041 acaagcccgt tcacattttg aaccgaagcc atttcctgat acacagctgc tctttctgca 1778101 cgagggctga tagaggaaat cggttcggta aacagcgcga catcagtata ccctttgctg 1778161 tacaccttct gaagaatctc ttttgtgatc catctgttgt cagtcgttac ggtatccagt 1778221 ttcagatccg gcagtttccg gtcaattaag attgttggaa tttgctgttc agcaaaagcg 1778281 cggagtacat ccttgttttc ccctgttgcg tttaaaatca agccctcaac cgaatgggct 1778341 tctagcttta agagcatttc ccgctctttt tcaggactgt tatctgtgtt gcacaccata 1778401 atgctgtatc catattgatc acaaacctct tcgactcccc tgaaagcagc gaccgaaaaa 1778461 ggatttgtaa tgtcagccac aacaaatccg attaacttgc ttttttttat tttcaaacct 1778521 tgtgccattt tactcggccg ataattcaat tctgcgattg cctttttaat gtttttcact 1778581 ttttcaggag aaatcgcgtc aatttttccg ttaatatagc gggaaactgt cgatttcgaa 1778641 actcctgcac attcagctac gtctttgatg gttgtatggc ctgttgtttt ctttttcatt 1778701 caagtgctcc tgtatctcat atatttgaaa ccgatttcaa aaccgttaca acaaaagaat 1778761 accataattt taaaatttgg gaagagtttt tttaataata tgtcaattca ttattttttc 1778821 gttgactctt ttcactattt atcctaaaat tttctttgaa accgttacca aaatattttc 1778881 attcaagtga tgctgaaatc ctaaccaagg gggaaatata atggaaaatc gttattctgt 1778941 acatcctgaa caagtaaaac gctttacaac agaggagctt cgcagtcatt tcttaatgga 1779001 ttctttattt acagaaaaca aacttacgat gtattactca catgaagacc gggttgtcat 1779061 cggcggagcg gctccagggc aaagtgaact gaagcttgat gcaggtgatt ttctaaaaac 1779121 agacttcttt ttggaacggc gtgaaatcgg gattattaat gtcggccagc ctggtgccgt 1779181 tagagtcggc gatgatgaat atgtgcttca aacaaaggat tttctctata ttggaatggg 1779241 caatcaggat gtatcgtttt caagcctgaa cggggaaaaa gcgaagtttt acttcgtctc 1779301 cgcttgcgcc cacaaaagct atccgacaca aaaagccgcc ctatctgaac tgacaccgga 1779361 ccgccttggt gatgatgcag cgtctaatgt cagaagtctg tacaaagtca ttcatcagga 1779421 tggcattaaa agctgtcagc tgatgatggg aataacgatg ttagatcaaa acaacaactg 1779481 gaataccatg ccagcacacg ttcatgaccg tcggatggag gcttatcttt atctggatct 1779541 tgaaaaggac tcaaaggtat ttcatttcat gggccagccg gacgaaacac gccatcttgt 1779601 tgttggaaat gagcaggctg tcctttctcc cgcttggtct attcattctg gcgcaggaac 1779661 atcaaactat agctttgtgt gggcgatggc tggagaaaat tacacattta cggacatgga 1779721 tctcattcca atggatgggc tgaaataaga tgggttatct acatgacgcc ttttcattaa 1779781 aaggaaaaac agcgctggtg acaggcccgg gaacagggat cggtcaagga atagccaaag 1779841 ccctagccgg ggctggcgct gatattatcg gcacatcaca tacaagcagt ctgtctgaaa 1779901 cacagcagct tgtggaacag gaaggccgga tatttacatc ttttacattg gacatgagca 1779961 agccggaagc gataaaggat tctgcagctg agctgtttga aaacaggcag atcgacatcc 1780021 ttgtcaataa tgccggcatt attcatcggg aaaaagcgga agattttcca gaagagaact 1780081 ggcagcacgt actgaatgtc aatctaaaca gcctgtttat tctgacacag cttgctggca 1780141 ggcacatgct gaaaagaggt catggaaaga ttattaatat tgcctctctc ctgtcttttc 1780201 aaggcggcat cctcgttccg gcttacaccg cgagcaaaca cgctgttgcc ggtttgacaa 1780261 aatcatttgc aaatgagtgg gcagcgtcag gtattcaggt caacgcaatc gccccaggct 1780321 atatttctac tgcgaataca aagcctattc gggatgacga aaagcgaaat gaggacattt 1780381 taaagagaat tcctgccggc cgctggggcc aagcggatga tatcgggggg actgcagtct 1780441 ttttggcatc acgtgcttca gattatgtaa atggacatat tttagcagtt gatggcggct 1780501 ggctatcccg ctgacaaata aaaaagctga cgaacgatcg tcagcttttt tccattacat 1780561 catgtgcggt tcaacaggca agaccttttt gacctcatca atgatgcgtt cattttctcc 1780621 gccagcgtaa atgtgaatcg agccgctgtc ttgattcgag cgaatcaggc gcccgatgcc 1780681 ctgccgtaca cgtaacaaca tatatggcag atcaacttct tcgaacggat cttttttcgc 1780741 tccgttgcgc ttcgctgtaa atacaggatc gtgtggcggg aacggtaatg accaaatggt 1780801 aacattcttc aatgcgtcac cgggaatgtc gagtccttcc cataagtgaa ctgaacaaag 1780861 tactgtttct tcttcctctt ggaatttctc tactaagctg ctgatttcct catcaccttc 1780921 gaagaaaatt ggatacggca gctcccatgc cgccgacagc tctttaaact cgtttaattc 1780981 ttcaaaagaa gggaaaagca ccagcgttct tcctttgtat cgtttgattg tttcaatcgt 1781041 ttcagccgtt ttttgttcag cgtccatatc tgtttttgcg tatagattaa tactcatttg 1781101 ctcgtcataa tcataagggg aatcaacagt taatgacaaa taatcatgaa tcccaagact 1781161 gtcggcaata taatcaaacg aaccgccttc tgacagcgta gcagaagaaa agatataagg 1781221 aattttctta gaaaacactt tttcgccaag tacttctgct accgttctcg gcatcacgac 1781281 aaaggttgat tctgcttcct ttttctccag ccagctgatc gcatcctttt gatatagaga 1781341 taatgaatac gccatttgtt caacatattc ttccactact gacagttcgt attgatcaat 1781401 cgtatacatt tcagactcaa atacaagtgc ctcaccgatt ttatcaagta aacggcaaag 1781461 ctcgtccgcc gcctttttga cacgatggtc attttttatt tctaaacggt gtgaaccggc 1781521 tacttccttt gattcttcag aaagaacata gaaaaattcg tcgtttgcga gaagcgcatc 1781581 ttcaatcaat tctgcaaact cttctctgat gtcattttgc agcaatcgtt ctaaaaacaa 1781641 ttcaagagta gactgcttca ctctataggt tagcgctttt tgcgcagcaa actctaacaa 1781701 gtgcccctca tcaaatacaa ctgcactatg atcaggcaag agcggcagct ggccctctcg 1781761 tttgcgtgat tcttccgtcc acacatgctc catataaaaa tcatgggaac aaatgattaa 1781821 gtccgttgac ttgcggtagt aatctctgga aagtgtcaga ccgcatctgt gtctcatatc 1781881 acaagtcaga cagtcctgaa acgagtcgta gcttacgtca gaccactctt cattcgatag 1781941 atttgcgtac tgcttacggt cgccatacgg ataaaagcgc tgcatcgcct gggactcgtg 1782001 gacaaatgac ggtaacgact cataaagatc cagccattta tcatcatcag aacgctgcat 1782061 tgttttttca agcttcttca agcataaata ttgctcatgt gattttgaca gccttgtatc 1782121 aattttcaga tcaagatgct cagccagctt agaaatatcg ccctcttttt tcaccagctg 1782181 ttcaattaat gtttcatccg cacaagcgat gatggcaggt ttgccgacat accttgcata 1782241 gctgattgca aaaagaagat ataccagcgt tttccccgtt cccactccag cttcggcgaa 1782301 catgactttt ttctctttaa acgcccgctc cagctgaaaa gccataaata cttgctcgtc 1782361 ccgaagatca aacccttttt cgggaaggat atcgtaaaac acgtcaccaa tccaattgtt 1782421 caattcttca taaaaattct ttgttttcgt taaagaaaaa ggcaaacgtg atgttgtcac 1782481 ctagttccaa cccccaacta ttcgacattc agaccaccaa taatatcatt ttccgctgat 1782541 gaatacaata aaaaacttgg caatgccaag ttttttgcag tttacttacg attgatcaca 1782601 tgcgacgata aaaaaggatg gtctgttgaa taaatatgtt ctaccgcttt ttctaaatca 1782661 gtttgcgcat gcgaaatcac agacggagac gaatcagtcc cgagctcctt cagctcgttt 1782721 gctgttgcgt caagcgccct ttgaataaga ttaaaatgtt cgctgttcag catgagatca 1782781 cctctgatgg aaataatcat cattgtatgc gaacttttca ttttatatac atgctttacc 1782841 gcatgttatc accgaaacat gcacaaacta cacttgatat tccgtctccg gattatccgt 1782901 cttatcaaca atattctatc agggagtgat gttgacatga gttatagaaa ccgattagat 1782961 cagcattctg aactgtttca tcacaattgg acgcggccta aacgttcaaa gtctcaagta 1783021 aacggtcaca ctgaaatgtc ccaaaccaac attatattga gaagcaacgc gaaagctcac 1783081 cgttggtaac gatagaatag ggctgaaaga tgaaagaaga cgcatgcaga gcgtcttctt 1783141 tttatgcgtt ttctgttttc ttgcgctgcg gtcttacttt tgaccagtat tgataataat 1783201 ccgttttaat aaacccgtta aagagttttc gtttcttcgt tgcttttctg ccatatgctt 1783261 cctcaaagtt ttcatttgat gtcagcatat acacagacca agtatcaagc ggctcgaacg 1783321 cctgccccat ttctttgtac atctgctcaa cggctttttt ctcgccgaga cgctctccat 1783381 atggcgggtt gccgacaatt acgccaaatt ccagatttgt ggtaaagtct ttgacctgca 1783441 tctgtttgaa ctggattaga tctcccaatc ctgcttcctc tgcattttct tttgcgattt 1783501 gaaccatgcg gtggtctatg tcgctagcga aaattgtaag cggctgatca taatttgcct 1783561 tttcttcgac ttcaagccgc gctttgttcc acagatcttt accgatccat tcccaatcct 1783621 ctgatacaaa atcgcggttg aatcccgggg cgatgttttg gccgattagc gccgcttcta 1783681 tcgcgattgt tccggagccg cagaaaggat caacaaacgg gcggtcaggc gtccaattgg 1783741 ttaattgcac caaagcggca gcaagtgttt ctttaatcgg cgcaccgccc tgatcgacac 1783801 ggtatcctcg tttgtgaagg cccgtccctg atgagtccag tgtaatcaaa gcctgatctt 1783861 tcaataaaga tatttccact ttatactcag cacctgtttc ttcaatccaa tcattggctt 1783921 tgccggactg cagcttgagc ttttcgacaa ttgctttttt gacgatccgc tgacagtcag 1783981 gaacgcttgc aagtgttgat tttaccgatt ttccgatgac agggaatttc ccgttttcag 1784041 gtataaatga gcgccagtta atcgctttcg ttttttcaaa cagttcatca aatgttttcg 1784101 ctttaaaaga agcaacctga acctttatgc ggtcggctgt tctaagccaa aggttcgcac 1784161 ggcagatggc aagtgcatca ccttcaaaaa taactttccc gttatcaacc ttgcattcgt 1784221 atcctaaatc tcgtacttcc tttgcgacaa cagcttcaat gcccatcggc gccgttgcaa 1784281 ttagtgtata cttcttcatc gtatcaccct gtcttttaaa acttttctct tttcaagata 1784341 aaagctctcc ttatacggga gagcttgttt tcatcatttt aaatgtaagt ggtctaacgt 1784401 tctgtaagcc atgttttgtt ccatcgtact gcaaacggct catcacctcg tactcaggcg 1784461 gcaatcatct atctacagaa agcattctgt ccttctctcc gttgaattcc gttaagaagg 1784521 ttcccctacc aaaatttggg tttctcgctc gaggggttta ccgcgttcca ctctcaccat 1784581 ttctagtgag acttcgtcac tgtggcactt tcaaggatac tcagccatat ccgaagacgt 1784641 aggctttttt cctgccgtca gcctctaaag actgccctag cttatgactt cgctaggcac 1784701 gaacactacg ggcatctcag caccgtgcga gcatggactt tcctctacag attcaagatc 1784761 tgcagcgatt acccgaacgt taagaacatg aattattata taacaactga ttacaattta 1784821 caagcgccat ttttttcaag cgtgatcaat cataaagctt gctgccaaaa acgtgttttt 1784881 ctaagttaga cagccgtttt aaaatatcaa agtttgttgt gttagattgc acaggctgtt 1784941 ttttgctggc ttcttcaagc tgttttttca gctgcagatt ttcctgctgc agttcttcaa 1785001 tttcttgatg gaaggtttca taatccttaa taatcatatc taaaaatttg tcaacgtctt 1785061 cttgcttgta gcctctaacg cctgttttaa attctttttc caaaatttct ttcgcagaaa 1785121 gctttacttt atcagcaagc atctttttca cctcgtatcg tgaatcatca catatatttt 1785181 ttcagaaatc tgtacggttg tcaaatttct ctctcattgt tagtagctgt cttcctccac 1785241 tgtcactctc aagtcatcca ttgtaataaa gtagatggga tagccatcct gttcgcgcct 1785301 tttttccgct gtcccaagca tatacttagg ggagccttcc ttttccgggt catataaaag 1785361 cagaagcccg tcggacttat caatgaagaa ctgatttttt tgtttgaatt gaagcgggct 1785421 ttcataagga cggtgagtca ggcttgcttc atagtctgcc tgagccagaa ctgcttcata 1785481 ctgttcttta ttcggttctt tccagttctt ttcctgctcg taaaatggtg tgatgacagc 1785541 tacctttaag tcagggtatt cctcctgcaa atcatatgca gcttctgccg cccacagctc 1785601 aactccaagc tggcccgaaa ttaaaatcca ttctaatcct tcatccaaaa aagcaatcag 1785661 ccggttttta atggcttttt ttatgtaata cagcgccttg tcatcctgct taaatatccc 1785721 cagttcaaac ggtttatagc ccgttattgc caatactttc atcatttcac ctgctttaaa 1785781 aaatggggct cccgtgggcc ccatttgttg tgctgcattg tttacaccat caagctgcac 1785841 gttttccata ctagtagtcg cagcaaggtt ttcctgcttg aaaatgctga tgcgtagccg 1785901 ggtcaacatt tgagaaagtg tgtggaaagt agtgaacgtg ctgaaaatgc tggtggttta 1785961 cgtttgttgt atgctgtggg tgaatgtgcg gcacgatagt cttcgaaaac gtatggtgtt 1786021 cacagcaatg agtaggatgg acaattggcg ccatcatatg cggtctgcag tgatgcatga 1786081 taaaatcccc tttccataaa ctttattaca atactaagtt atgaaaaata aggggtacat 1786141 gttctgatgc aaagacctat tttaaaagtg tgcaattaag ctgtctttaa agtttgaaaa 1786201 cacaaaagca atcaaaaata ccacaacaaa gaacaagtaa aaaacaccct tatacatacc 1786261 aactctccct ttaaaaataa ctaacgtcat tttacaggat tcgccgctat tctacaacaa 1786321 aatcaatgtg aattcagcaa aaaaaattca tggcgaaaca agtcgtcttt tgcgctttcc 1786381 cggggaatat ttaagaggaa tatttcctct ttagccgggc aattctcaca tgcagttttt 1786441 cagtttcttt ctctgataag catgccgcat cgctaagcga ttgctctgct acttgcaatg 1786501 cttttccgaa ttcttttttc ttatgctcaa aatatttcgc gagctctatt acagcagcgt 1786561 atctgcactt ctggttttgc gagcgggaca gcttttccca aagcggcact gcttcttcca 1786621 agcggttttg ttttttgtac aggagcgata aatccagccg tgcactgtcc tggtcctcaa 1786681 acgatttttc tataagcctt tccaactgct tgatcgcttg gtccgtttct ttatgagcca 1786741 taaaccattt cgccatagca taggcttcac tgtgttcttt tggcgcatgt gattctgaaa 1786801 ggattttttt agacatatgg atgtacaatg aaatgagtga taacacatcc atttcattat 1786861 gatgcaggac accttttaaa agatccggct cttgcgcctt gataaaatga aagtaaagca 1786921 ttggcgccaa gtagcccggt gtgtcttcta gcctgcggat gccgagctcc tctttttcaa 1786981 ccgtgccaag agatacacgg tccattttgt gtttccacag gcgtctagct ccatgcaaaa 1787041 gatcaaagtg gccaaactcc ggaagcttcg gaagtctgtc acggatcaag gtgtgccttg 1787101 ttttcacctg cggccaatca aaggctttgc cgttgtaggt cacaagtgat gtaatgtcaa 1787161 cctcgcttaa aaagctttgg tacaaggcga cttcgttccc cggtttgggc aaaagatgct 1787221 gtttgactgt cactcggtct tcatatactc tcgcatgccc aagcaaaaaa atggtattcc 1787281 cagctccacc cccaagaccg gttgtttctg tatcaaagaa aaagaggttg tttttgttat 1787341 acccttttgc tgacaatgta tgcgacaggc cgctttgatt ccacagtgtg atcacttcct 1787401 caagctcaga aaagctgtat aacccatggc ggtgagaaag cggatattct acttctctga 1787461 tgaggcaata ttcatcttcg aagatgaaag gcttcatgcc aaaagcctcc cactcttcta 1787521 aaaacgggat gtcatcaaag tggttttctt gtttgcctgc ttctattttt tgttctcctt 1787581 cgtcgagcgc catgtgcttt ttcatccgtt ggagtttccc ttttaatgac atatccggcc 1787641 tccctcctta cgacatttga tccaacagct gcaaaattct ttcctttgct tttatccctt 1787701 ctatttccgt acctatacaa gacggacagc cgtcatgaca aggacaatgt gtaatcagtt 1787761 gtttcgccgc ttcattaatg tctgaaaaac gtttaaagac ttcctccgcc aaaccgatac 1787821 cgcccggata atgatcatat aaaaatatgg ttggcaatcc ggtatgggct gctttaattt 1787881 gagaaacaac atgaacatca tttcgatcac acatgatata cacagggaca atatgctgca 1787941 gcacattcga gatgccaaga agcagctgtt ccagtgtctt ttccccgatg tcttcatccg 1788001 ctgttttgat ttcgagccaa gctgcacttg tatgcagttc ttcttccggc aaatgaatag 1788061 gtccagaccc aatattttca aaagtggtca tttttatttt tttaaaaatg gtcggcaggg 1788121 cattgacagt gacgtctccg tagtgcaatg acgtacggct tttttctttc gttttatcga 1788181 tttctaatac cttcagctga actgccaggt ttgcatccgt ataatattcg acatcgactt 1788241 ttctgacata cgccttttta tggtcccaat cgagcttctc aacttgatac tgaacgcctt 1788301 catgcaaata aatcgcttca tcatgcaaaa gcgtcatcgc actaaaacgg tccatttcac 1788361 cgataatcct tacatttgca atatccgact gatcaactat aacgacattt tcctgggagg 1788421 cggaacgcaa actgatgttt gacgcaggga acgactcact tgcccaatgg taccgttcgc 1788481 cgttgcggtg aagaacagcc tcttcctgaa gatactcaag aatatcactg acttccatgg 1788541 ctccaaattc ttcatcagct ctaaaaggaa gctcataagc cgcacacttt aagtggtcta 1788601 ctaaaataat caaattctcc ggattgattc ttgcagattc cggcgaacga ttaaagaaat 1788661 attcaggatg ccgcacaata tattggtcaa tcggtgttga attggctacc atgataatca 1788721 aagattcacc gtgtcttctg ccggctcgtc ccgcctgctg ccaagcactt gcaacacttc 1788781 cgggataccc cgtcattaca cacacttgca gctggccgat atcaacacca agctctaagg 1788841 cattcgtact gaccactcct aaaatgtcgc cttctctcag tcctctttcg atttctcttc 1788901 gctctttcgg cagatagcct ccccgatagc ctctgattga ttttgttcca atctcttttt 1788961 tcacaagctc ctgaatatgg cttaaaataa tttccacccg aactctgctt ctggcaaaaa 1789021 caatggtctg cactttgttt ttaaggaact ctttcgccag ttcattcact tctgcggttg 1789081 cgctccttct aatattcagc ggtttgttca caattggcgg attgtaaaac acaaaatgct 1789141 tgcgtccgct cggtgcgccg ttgtcatcga ccagccgcat cggtttgcct gtcagctgct 1789201 ctcccaattc ctttgggttg gcaatcgttg cggaagtaca aataaaaact ggatcacttc 1789261 cataaaaccg gcagatccgc ttcagccgcc ggatcacatt tgccacatgg ctgccgaaca 1789321 cacctcgata cgtatgaagc tcatcgatga cgatatactt aaggttttca aacaaactga 1789381 cccatttcgt atgatgcggt agaatggcag aatgcagcat atcggggttt gtaatgacaa 1789441 tatgacctgc ttttctcacc ttttgtctga ttgccggaga cgtatccccg tcatatgtaa 1789501 agcttttaat atcaatgccc atttcatcaa taatttcatt tagctcgctc ttttggtctt 1789561 gtgccagcgc tttagtcgga aataaatata acgcccggtt tgtttcatct tgggcgatgg 1789621 actgcaggac tgggaggttg tagcataacg tttttcctga tgctgttggc gttacggtaa 1789681 cgatgctctc tcctttttgc acatattgaa aagcggaata ttggtgagta tatagttcat 1789741 caatgcccct tttcgaaagg gccgctttga ttctctcgtc tatactttcg ggcataggcc 1789801 ttgtttttgc ttcccgaggc tcaatttcat gccaattcac aacgttttca tttcctttta 1789861 aatcagaaat gagttcagtc agtgatttct ttttcattct ttacacctct ttgtcaagta 1789921 cagtttaccg aatatttgtt tgcatggcta ggtgcaaatt ttatacagtt gaataaaaaa 1789981 agcaaggcat acgccctgct tatttcgctt ttattgtaaa gagctttgat tcgcctttac 1790041 gagcagcctt ttcgcctgcc gataccattg atcctacagc ctcaccattc attataacga 1790101 ttgggatgac tgtgctgctc gctttttctt ttattaattc caaatcacat gtaatcagcg 1790161 ggtcaccgac cttcacttta tccccttctt taatgtgggc agtaaatcct tctccgttca 1790221 tattgactgt ctccagcccg acatgaatta acagctcaat tcccgagcga gtccgaatgc 1790281 caacggcgtg tttggtgtgg aaaatctgaa tgacttcacc ttcagcggga gaaacgattt 1790341 caccgctaga aggttccacc gctattcctt ctcccatcat tttctgtgaa aaaacagggt 1790401 ccggtacatc tgacaggtcc attactgtac cgtctgccgg agaataaata acctcttctg 1790461 tcaccttttc ctgaattttg cccattccga ataatttttt cagcaatgta ttttctccct 1790521 tctcattcac ttcaaccgtt atcccttcat tcaccactat ttaaccacac tttcaatttt 1790581 gcttcaattt ataacaacat ctggcataga cgcataatct ggttaaaaaa ggcggtggcg 1790641 atattggaat tccatgatga caaaaagaac gaactgcaaa agaaagaaga aatcataacg 1790701 gaggcaatcg acactctttt tcaatcctca gcgttcggca accttataaa cggatttcag 1790761 aacctaatca actcgagttt aaaggatgtg cagacgacca tacatgtcag agaaagagat 1790821 actgggctgt atatcgatat taccattccg gcgacgtttc gagatggcga gatcgtcgtt 1790881 gatgttaaat cgaggtatct ccatgtaaca ctccaagaaa aacagaaaca ccaaaatgag 1790941 gctaccttta caagcatgac aagaacggtt cagctgcctt atgaagttcg ccaagaagat 1791001 atggaaacgt cttggaacga gcagacaatg acacttttct ttccaaaaaa taagcatgaa 1791061 tgaacgattc attcatgctt ctatcattta aaaaagctgg taaatccctt tattaaagat 1791121 ccgacctgat tcattgcact cattacttga cctgtcgtat ccatcatttt attaaaatca 1791181 aattgcccat tggctttttt gaactgcgac ataatgcttt gaaattgtga aggctgctgt 1791241 tgattaggcc ttgggatagg ataagggtta gaaaatacag gcggctgcat aggcataggc 1791301 tggatcggag cataaggctg ataataatcc tgctgtccat aatgctgctg aggcagttgt 1791361 tgctctaaat aaccgggtgc agcctgctga taatatcctt gcatatgctg aggataataa 1791421 tagcccattt gccgaggata gcttcgagag ctcccgttca ttgcgattcc cccctaaaca 1791481 caacatattt ctcttctata tatgtatgaa tgacttctat tgtttgtgtc acaagtgatg 1791541 attagcattt gtcaaattgt gtcgaaagtt taaatttttt aaaaacagaa aaaagtcgaa 1791601 tcattatggt accatatttt caatacagat gagaggggat gcaccataat gaacgtatca 1791661 tacttaagca aacgttttgc agaaatgaag aaatatgaaa cagactgtat gaataaactg 1791721 atggactttg ccaagttcct ctatattcaa ggacatctca gcataactga gtttcgtaac 1791781 agtatgaagg ttctcgaagc aaatggagca gaaagcccgg catatgagat gaattaacgt 1791841 ccggccccct ataaaaacga aaagaagaca gccttttacc ggctgtcttc tcttgcaatt 1791901 tcatccttta ctgcgtgcaa tgtataaagg actgactcag tgatgtcctt gaatcgtttt 1791961 ttatgaatat gatgaacata agattgaagg accaattcca ggaaattatc ctttacggcc 1792021 tcaatttgct ctttatgcac atattttggc cggcggactt ttatcaattc aagagcaccc 1792081 tctgcccagc gagcagccag ttcatcattc tcttcaactg caggctttat cgtctcaaaa 1792141 aaatcataag aatgattact gttttttcct tcctgatacc gatcagcgcc tttttcagca 1792201 acttcaatca tttgctcggt catttccagc aaagtttgtg atagcaatat ctttcacctc 1792261 aatgcctatc gtaccaaatt tcactcacaa attcagccga tgcggtatac cttctcaaac 1792321 gcatacctgt gttcaggcga ttgatacagc tcatttatac aaatatgaag atctatgatt 1792381 tcttcttcga gcacacttag gcgatcgttc tccgtttccc gcatctcagc ctctaatgca 1792441 tttacagaat gattcaggct ttgctcagct cgcgttaatt catcttctat atcagaaagc 1792501 atacggagaa tatctgtctt gcatacataa ccggacattc gtgtacctcc ctttccttgt 1792561 ctctcccggt taacattctt tgctctcaag gctctttcct tcctcatgac aaaactagaa 1792621 gcaaatcgcc aaacaaacag gtattccacg aaaagctgaa gttttcgaca aaaacacccg 1792681 caaaaattgt atgatcctcc tcattaatgc aaacgatact tgtgaggagg tgccgtatga 1792741 aaacaagacc gaaaaaagcc ggccagcaaa aaaagactga atcaaaggca atcgattctt 1792801 tagataaaaa attaggcggc ccgaaccgcc cttctacgta agaagcaagg aatttccttg 1792861 cttctttatt ttttcagcca ctgctccacc gcaaaaagcg catgaagctg gcgcttttta 1792921 tgtaaatacc agtctgtcaa ttcaatctgc ttcggcaatt cctcgcgcct aaagaacgtt 1792981 ttctttatct ttccatgaaa ccaatctgtt ttcgttccgt ctaatgagtg gattaactca 1793041 gggtagcatg tccttagcat aggagatgtt ctttttgtaa tcccgatcat cttttccata 1793101 tcaaaacggg aacctgtgtg cggcactgtg tgcaaaaagt gataaaaaga ggagaacaat 1793161 tctggcttga acagcaattg agacagctgc tttcccagcc ttatcctttc ctccgccttt 1793221 gaaaagcgtt tcactgaaat gccgtaaaaa aacccatttg aggaaggaaa aataacggtg 1793281 ttaaaatgaa accagtcact taaataaaaa ggaatcgtgt caaaaacatt ctttttaaac 1793341 gaaggatttt gtataatagg tgtttggata gtgttttgtt catttataat gagggcatac 1793401 attagccgct ccgtatttcg ctcatgccaa aaacgggtcc attcttccga cataaattgt 1793461 gagacgccaa acacatgcag cagatgaaac agcggtttcc caactctttt tgaccagtgg 1793521 tataaaagaa gctgcggata ggcatccgaa aaaataagcc agttcgctct ttcataggct 1793581 aaaaagaacc atttttgctg tctctcacgg agtccaagct gaaacagact gccttttaag 1793641 tcagtcattg accagccggc attacgagaa acgaaagaag ccaaaagcga ccatttgatt 1793701 tccggatgac ggtcgtaaaa tgctttataa gcatttgttc ttgaaatgtt atccgcgttt 1793761 ttcatttttg tctgccgctc aatccggctc agaagctttc tgatggcctg ttgttcttgc 1793821 acgttcattc acttccgtca tgattagttt aataaggagg atgagaaagt gattcggtat 1793881 cctaatggaa aaacatttca gccgaaacat tcggtttcat cccaaaacag tcagaaaagg 1793941 gccccgtctt acagtaatcg cggaatgacc ctcgaagatg acttaaacga aacgaataag 1794001 tattatctga caaaccaaat tgccgttata cacaaaaagc cgacacctgt tcaaattgta 1794061 aatgtccatt atccaaaaag aagtgccgca gtgattaaag aagcttactt taaacaatca 1794121 tcgacaacag actacaatgg gatttacaaa gggcggtata ttgattttga ggcgaaagaa 1794181 acgaaaaaca agacctcttt ccccctgcag aattttcatg accatcaaat cgagcatatg 1794241 aagcaggtaa aggctcaaga cggtatttgt tttgttatta tatccgcttt cgaccaggtt 1794301 tattttttgg aagccgataa gctgttttat ttctgggaca gaaaagaaaa aaacggcaga 1794361 aaatcaattc gaaaagatga gttggaagaa acagcttatc cgatttctct tggatacgca 1794421 cccagaattg attatattag tattattgaa cagctttatt tttcgccatc atctggtgcg 1794481 aaaggttgat taacgaaagg ttgagatgtt atgtcagatc aatttaacag ccgtgaagct 1794541 cgacgaaaag cgaacagcaa atcgagtcct tcaccgaaaa aaggcaagaa acgaaaaaag 1794601 ggcggattgt ttaaaaagac ccttttcact ttactcattc tgtttgtttt aggcgtagtc 1794661 ggcggtgctg ttacatttgc cgtcatggtt tctgatgcgc cgtcccttga tgaaagcaaa 1794721 ttgaagacgc cttattcatc aacgatttat gataaaaatg gaaaagagat cgccgaagtc 1794781 ggcgccgaaa aacggaccta cgtctcgata gatgaaattc ccgatgttgt aaaagaagcc 1794841 tttatcgcga cagaagacgc tcgtttttat gagcaccacg ggattgaccc tgtccgtatc 1794901 ggcggtgcat tagttgccaa ctttaaagac ggcttcgggg ctgaaggcgg aagtacgatc 1794961 acccagcagg tcgtcaaaaa ctcccttctt tcacatcaga agacgttgaa acggaaggtg 1795021 caggaagtat ggctttcgat tcagctggag cgcaattact ctaaagatga aattttagaa 1795081 atgtatttaa accggattta tttttctcct agagcatacg gaatcggaaa agcggcggaa 1795141 gaatttttcg gcgttactga tttaagcaaa ttgactgtcg aacaggctgc gacgcttgca 1795201 ggaatgccgc agagcccaac agcgtacaac ccggtcaaaa acccggataa agcggaaaaa 1795261 cgacggaaca tcgtactcag tctgatgaaa aagcaaggat ttatttctga ttctcaatat 1795321 aacaaagcga aaaaagtggc agtgaaagac gaaggcgtcg tgtcacagaa ggaatatgaa 1795381 aaagcaagta caaacaaata cagcgcattt gttgaagagg ttatgaagga aattgatgaa 1795441 aaatctgatg tcgatccatc tgctgacgga ttaaagatct atacgacatt agatacaaaa 1795501 gcacaagata aactagatga attaatggac ggagacaccg tcggatttac tgaaggcatg 1795561 cagggcggtg tgacgcttct cgataccaaa aacggagaag tccgagcgat tggtgcggga 1795621 cgcaatcagc ctgtcggagg ctttaactat gctactcaaa ctaaggcaca gcctggttcg 1795681 accataaaac cgattttgga ctacggacca gttattgaaa ataagaaatg gtccacatac 1795741 gaacaaattg atgactcagc ttatacgtat tctaacggaa aaccgattcg tgattgggac 1795801 cgcaaatatc tagggcctat ctcaatgcgt tacgctctgg cccaatcaag aaatatacct 1795861 gctttaaaag cattccaggc agtcggtaaa gatactgctg tagactttgc aaatggactc 1795921 gggcttggtt taacaaaaga taatgtaaca gaggcctatt ctattggcgg tttcggtggg 1795981 aacgatggtg tttctcctct gacaatggca ggtgcataca gcgcgtttgg aaataacgga 1796041 acgtataatg aaccgcattt tgtaaaatct atcgaattta acgatggcac gaagcttgac 1796101 ttaacaccaa aatcaaaatc agccatgagt gattatactg cgtttatgat tacagatatg 1796161 ctgaaaacag ctgtgaagac aggtactgga cagcttgcac aagtacctgg tgtagaagtt 1796221 gcaggaaaaa caggaacgac taactttgat gataatgaag tcaaaaggta caatatcgct 1796281 agcggtggcg cccgagattc ttggttcgtt ggctacacac cgcaatatac agctgccgtc 1796341 tggacgggaa tgggagaaaa cgaggctgga aagaaatcac tttcagctga agagcaaaaa 1796401 gttgcaaagc gcatcttcgc ccagctcatc gccgatgtcg atgacggaag cggatcattt 1796461 gagaagcctg acagcgtagt ggaagccacc gtagaaaaag gttctaatcc ggcaaaactg 1796521 gcagggccaa atacgccaag cgataagaag ctcacagagt actttgttaa aggcacagct 1796581 ccttctactg tttctaaaac atatgagaaa gaagaaaaag aggaaacagc taaactgtct 1796641 ggtttaaacg tgaaatacga taaagacaat caatctttaa cgttaagctg gaattacgac 1796701 ggagatgcga cctttgctgt taagcaatct gttgacggcg gcagctactc ggaaattcaa 1796761 aacagctctg caaaagaggc agttatttcg ggtgtgcagc caggatctgt atacaaattc 1796821 gaagtaacag ccgtcagtga tgatggcaaa agtacagctt ccacatctta tgaggtgcca 1796881 aaagctgaag acgatgaaga taaaaaagac cagcaacaaa cggatgatga aaaacaagat 1796941 gatgagaaga ctcaggatga tacacaaact gatgattctc aaaaagatga cggtcagacg 1797001 gatcaagatc agacagatga ttcaacaaac gatcaagaca aaaaacaaga caatacgaac 1797061 accaatccgt ccgacaacaa taaccaagac caatcaaacg ataatgataa cgacaacagt 1797121 aacaaccagg atacgtcgga tggtgattcg aactctggta agaatgattc aacaggttct 1797181 gacacgaata aaaataaaac agacacatct aataaaacac aaacaaactc atcatccatt 1797241 gaaaaaacaa attaaacaaa aaagccgtca cctttggggt gatggctttt ttggtacaca 1797301 ataaaaaacc tcccgtttta acaggaggtt ttatcgattc atcgcatgat atttataaaa 1797361 atgctttttc atttcggtaa tcagctcatc aagctgaata aagcaatggt attgggtcgg 1797421 cttaagaaga ataaattcca ctcgttcagc ccaattaatc ggctttgcgg gatatgattt 1797481 ctccctcagt tcttgccaat cgagcgattt caccggctca cctgctgtcc aatgtaacga 1797541 agccagcaaa cacacaatgc cctttaacat ttcgttttgg tcacatctcg attttcgtgt 1797601 ttgaaagact gggagaagtg atgctttgat gtcatcccac acttcaaata aaagcggaac 1797661 gtatttcccg ctgtcctccc atggcaaatc gccttgtaat tccgtgcaga aatcaaaata 1797721 cacgggattg gtctgcaagg ttttcttcat atccgaggaa ctcttctggc caagactgcg 1797781 caagtattgc tcataggaag ccaacacttc ttttgcttgc gtcatcgttt caccagtcct 1797841 tttttatccc tcttctgccc ttctctgcac aaagaaagca gcggacactc cgcacagcgc 1797901 ggagattggg ctttacagtg atatctgccg aagaaaataa gccggtgatg cgtaacggac 1797961 caatcttctt tgggaacctt gcgcatcagc gtcttttcaa cttccagaac cgagtccttc 1798021 caccggcaaa tgcccaatcg tttgctgact ctctccacat gggtatctac ggctatggcc 1798081 ggcacgccaa acgcaacgga taccactacg tttgcggtct ttctcccgac ccctggcagt 1798141 ttgacaagct catcgcggtc tctcggcact tctccgccgt aatcttcaat aatcatttta 1798201 ctcagctttt gaatattttt cgctttatta cgatataaac cgattgattt aatatcctgc 1798261 tgaagctctt ccagcggaac agccaaatag tcttccggcc gtttatattt ttggaataat 1798321 gttttggtca ctctgtttac aagtgcatct gtacattgcg cagataaagc aacagccacc 1798381 actaattcaa aaggattgga atgaaccagt tcacactccg catgaggaaa catgtcacct 1798441 atcttgtcta aacagaattc aatttgtttt agatttaaca cgattgtcac cttttcactt 1798501 tattgttcaa gccaattgta aaaaggaacc tgccttttat actctttttg cggttcattc 1798561 tgctttgctt gtacacgccg gaatttttgg ctgtgtattt ttgcctgctc cacagtttta 1798621 agcccatttt tcttccattc aaacaaaatc cggtcaatgt agcggaaact gagttttcct 1798681 gatagtacag cctcttttaa cgcgtgtttg atcagttgtg cgtcatgctg atcctggtcc 1798741 tgccagatcg ccagcgtttc acactccaaa ggcgataacg gtcttgcgaa ctcttcctca 1798801 aaaatggtat aaaggctttt ttgttcccct tctgcttttc tttcctgtgt ttgattctgt 1798861 gcaagctgaa tatactcgta cagcttgccc cataaaggct gaagagaata tttctcaaat 1798921 ttgatgccgt tttgatcctc gcattcttca ataaacagaa agcctttttg aataaacatc 1798981 cgcaatctgt ttgtacattc ttcaacagaa attgacatac cttcctgcag ctgattcggt 1799041 gtaggaaaat atgatccttt ttctaaatgc attttaattt ttaacagcag aataagttct 1799101 gtttcattaa gcccaagctg tttataatgc gtgagcagaa gattggggat ggttgatgtt 1799161 ccctgctcct gcatatcaat aaattgctgt tttttcatcg tcacacctct tactgtaaag 1799221 gattgtgatt gcccctttac tgtaaaaagt ctcccttgca ggagactctt ttttgtttca 1799281 tttgaatgta ttacggatac agacggttta acagtcttgg gaacggaatc gtttcacgaa 1799341 cgtgaggcgc tccgctgatc caagctactg tccgctctaa tccaaggccg aagccggaat 1799401 gaggaactga tccatatttt ctaagttcag cataccattt ataagcgtca gaatccagtc 1799461 catgttcttt aagacgcgat tccaaaagtt ccatatcgtg aatccgttca gacccgccga 1799521 tgatttctcc atagccttcc ggcgcaatca agtcagcgca aagcacaacg tcctcacggt 1799581 cagaagccgg ctgcatatag aacggtttta aggacgtcgg atagcgagtg atgaataccg 1799641 gtttgtcata atgttcagca atcgctgttt catgaggcgc tccgaaatca tctccccact 1799701 cgatatcgtc aaagcctttt tctttcagaa attcaatcgc ttcatcatac gtaattcttg 1799761 ggaacggggc tttgatttgc tcaagttttg acgtgtctct tcccaatgtg tttagttcaa 1799821 ttttgcaatt tttaagaact gattgcacga tgaaagaaac gtaattttcc tgtacttgaa 1799881 ggttttcttc aaattctaca aacgccattt ccggttcgat catccagaat tcgattaagt 1799941 gacgctttgt tttagacttt tccgctctga atgtcggtcc gaaagagaat acttttccta 1800001 aagccattgc cgcagcttcc atgtagagct gtccgctttg agacagatat gcatcttcat 1800061 caaagtactt tgtcgcaaag agttctgttg ttccttcagg tgcgcttcca gtcaaaatcg 1800121 gcggatccac ttttacgaag ccttcgttat taaagaattc gtaagtcgcg cgaatgattt 1800181 cattacggat tttcatgatc gcatgctggc gctttgaacg cagccataaa tgtctgtgat 1800241 ccatcaaaaa ttccgttccg tgttcttttg gtgtaattgg ataatcggtc gcttcgtgaa 1800301 tgacttcaat atctgtcaca gcaagttcat atccaagcgg agaacgctcg tcctctttga 1800361 caatcccttt tatatagagc gacgtttcct gcgtcactga tttagctgtt tggaaaatgc 1800421 tttcttccac ttccgctttt actacgacac cctgaataaa accggtaccg tcccgaagct 1800481 gtaaaaacgc aattttcccg cttgaacgct tattagcgac ccaagctccg atcgttactt 1800541 cctcacctac gtgcttgtac acttggttga ttgttgtttt caacatattt ccctccaaaa 1800601 caagaaagac attcggaagc tcattgcccc gcgaactctt ttatcatcac tttattatac 1800661 ccgctcttaa ctaaccgggt caatgcagat aaaaagcggc ttttctgtca gccgcttttt 1800721 gatctgttag ctatgttttt ctacaaaacg cttgattctt tcaatggctt cttcaagaag 1800781 atctaacgat gttgcataag aaagacggac attctcagga gagccaaatc cggatcctgg 1800841 aacaatcgca actttttcct cctcgagaag cgctttaaca aattcatcta catctttgaa 1800901 accgcaagat tgagctgcct cttttgcatt tgggaacaag taaaaagcac cttccggctt 1800961 cacgcagctg aaccctggga tttctatgag ctttgcatag atcgtattta atctatgttc 1801021 aaatgcttct ctcatttctt ccaatggctc agaaggcccg ttataagcag caatcgctcc 1801081 gtattgtgcg attgatgtcg ggtttgacgt gctgtggctt gcaaggttcg tcatcgcttt 1801141 aataatgtct tcagagcctg ccgcataacc gattctccag cctgtcatgc tgtgggactt 1801201 cgatacgccg tttataatga ccgtttgctc tttcagtctg tctgacagct gtgcaatgga 1801261 aacatgtttc tttccgccgt atgtaagttt ttcataaatt tcatctgaca caatcaagat 1801321 atcatgttca aggcacactt caccgagcgc agatagttct tcttccgtat acatgacacc 1801381 agtcgggttg cttggagagt taataacgat tgcttttgtt ttttccgtaa ttgcattttt 1801441 cagctgctca ggcgaaattt tgaagtgatt ttcctcaagc ccttctacat aaacaggctt 1801501 tccgccagcg agtttcacct gctccgggta gcttacccag taaggcgttg gaataataac 1801561 ttcatcttct tcatccaaaa tcacttggaa aagggtatac agagcatgtt tggcaccagt 1801621 gcagacaata atttgagacg gtttgtattc aatattctgg tcgcgtttaa atttctctgc 1801681 aatgctgttt ttcagttcag ccaaaccacc ggaaggcgtg tatttcgtat ggccctcgtt 1801741 catcgaacgc acagcggcat caataatatg ctgcggtgta ttgaagtcag gctcgcctgc 1801801 tcctaagccg atgacatcat ggcctgcggc tttcagttct ttcgctttcg ctgtgattgc 1801861 cagtgtggtt gatggtgtta atgcggatac tctttttgcc agtttcaact tgaactcccc 1801921 ctaattcgtc ttaaggcgtg atatttttga gaatctttcc agttgtaaag tccacataac 1801981 ttaaactgta ttgcccttct ttgtctaagt acgtcacttc ccaaagcagg acgtttcctt 1802041 ctcttgccag atgaacctct ttttgctttg aaaccagccc ttcatccttt atgattttcg 1802101 ccgctttgtc ttcagagatt ccctctttcg cttcttttga gagaattttt gcttttttat 1802161 cagcaggaac ccagacatat aatgcagtgc cttttttatc cgttcccttt acaacataat 1802221 atttttcttt tccgacaaat gtttcgactt gatcaacatg ggcgagatcg gtttcttttt 1802281 tagcttcagc agctgctgct tcgtgcccct cttccttttg tgccatggct gatttataaa 1802341 tgcttgccga gacaagaagt actgctaaaa aaataatacc aaaaatgacg gtaaatatta 1802401 atgctttttt tctcatcttc tcacctacgt acgataaatg gtaaaaacgg cttggttttt 1802461 gttttcttca tccagcgcaa ggccgaacat cagattgtct cttttcagtg tacgattcaa 1802521 tgtgtccaca attttataca gatcatcaga atgctctaca ttaattgttg aaagaatttc 1802581 gattttactt tccatttttt catcctccag tttgaacaaa tattgttagt catactccat 1802641 ttcaggacac gccatactag tatcacagag cgggaaatcc gcttttaaat aaaacaccat 1802701 cctactccca caccgcaaaa gccgctttat gcggctttta ttctttttcc cctgcaacat 1802761 aagcttcaag ctcgctgtca gtcatttcgg atactgaggt tgtcggcaag gcatcaagaa 1802821 acagccggcc gtaaccagcg gttttaatcc gtctgtccaa tataataatc gttcccttgt 1802881 ctcccgcaga acgcagcaag cgtccgattc cttgcctgaa ggtcagcaca gcttccggta 1802941 atgacactgt ttgaaacgga ttctttcctt ttttgcgggc aagctcacat tttgcagcat 1803001 gaagcgggtg atcaggggac cggaatggga gcctcacgat cattactgtc gtcagctcat 1803061 caccagggaa atcaacgcct tcccaaaaat gatttgttcc gagcaggatc gcctgattgg 1803121 atgttttaaa agtcttcatc agtttgccgg gacttccgcc tgtaatccct tgtgccaaga 1803181 gctgaatgcc ggaagcactc atgttatgct taagctcctg gtgaaccttt ttcagcatat 1803241 catgggatgt aaacagcaca aggattttag gctgtttttc ctttgccatc agttcgatat 1803301 aacgggctgt atcctgtata aattcaggtt gccctgtatc ctgaattgat ttcatttctt 1803361 ttggaatcat cacctgcata cgctcatcgt aagaaaaggg tgactcaatt ctcattgtcc 1803421 gcgggaaaaa gtcactcagt cccagtcgtt caatcataaa ttgaaaagaa ccttcgactg 1803481 taagagttgc agatgtcagc accacactat ttttgcgcgc gaaaaactga tcagccagaa 1803541 gttcaccagg ttcaagaggc tgtgcgtaaa tggccactgc atttttcgca ccctttgcat 1803601 ctatttcaat ccaaaccgct tcatcgtcat cagagccaaa gaagagcttc tgcaacgtct 1803661 gacagtaatg ctgcaagcct ttcatgcttc tttggtattc atcggctaaa aagacggttt 1803721 tgctcttcat gcccttcaaa tgtttttcca taagggatga ctgcgcctca aaaagctgct 1803781 gcaaatgtgt cagcatggaa caaagcctct ccgcaccatc tgttaagatc gaccagcttt 1803841 tatcctggct ttctttgttc accttaaaca ctagacggtt taagtcttct ttaggttttc 1803901 ttcgtttgac aaaagaatgt acagagctaa agaaagcatc actttctgct tgaacgtgct 1803961 gaagccactc ttccaattcg aaaaatgaat caaccggcag gctgtttcgc tggaatagct 1804021 gtctcatctt ttttagaagt ccctgctcct tcagagtgcc gattctgctc aatttcgtat 1804081 gcaattctat gtacgtggct cttttcccta aatgttcgct tgccgcacgt tcaaaatggt 1804141 gtgcttcatc aataataaat gtgccgcttt cgggaagcct ttttttatgg ctgccttcat 1804201 cggtcagcaa aagagaatga ttggtgatca ccaaatcgga acgcatagca atctgtttgg 1804261 cccgctcgta aaaaccgatc acatgctcac tgcgacttct tttataggag tcatcgtcat 1804321 aagccaatct gtcccacagc aattttccgc ctgaaggcaa attcagttcc gctacatctc 1804381 ctgtatttgt ctctgtcagc caaacaagaa gctgtgcctt tgtcagtacg gcatcataat 1804441 tatcatcttc ttcatgaagc acctgctcaa atttatacag gcataaataa tgcgattgcc 1804501 cttttaaaat cgccgctgtt accggaaatg gaaacagatc ttggacaatc ggcaaatcct 1804561 ttgtgagaat ctgctgctgt aaaagcgtcg aatacgtgct gattatgacc ggcttttttg 1804621 atttcttggc aaaaagcgca gccggaataa gatagccaat cgtttttccg atgcctggag 1804681 gagcttcaat cagcgcatgc tcacgattgg caaacgcatc agccacctct ctcatcatca 1804741 tcatttggcc gtctcttttt tcatacccag gcattaactc tgacagcgct ttttcatttc 1804801 ccgcttccca gctttcgatc tcaaatgaga agttctcgtc ctcatttata cgaacatcga 1804861 tagcttcagg ttctctgaca gaaaacgaag aaaagcgcgt atagcccggt atctcggtat 1804921 gtctgttttc attaatgaac atatccaaca aatgcgtcag atcactgatg aaatgctgcg 1804981 aaagccttct taactgcttt aatgtcggat aaggaagctg ccgcagcttt tcaaggattt 1805041 ccaaaaaaat aagccctgtc acttcagcat cgctgtcagc ccggtgcggc tgatcatgcc 1805101 gcagctgaag ctcctcgctt aattccgtca gcttataccc ttcaaatccc ggaaaaacaa 1805161 tgcgtgagag ctcgacagta tcaagcactt cacaatctgg gagctgaaag cccgccttat 1805221 gtagctcata cttgacaaat ccaaggtcaa aatggatatt gtgggcgaca aaataagcgc 1805281 cgtcaagcaa ttggaatact tcttcagcaa ctgcttcaaa tggctgttca ttctcgacca 1805341 tttgattaga gattccagta agctgctcaa taaaagcagg gattgattta tttggattaa 1805401 tgtattttga aaaccgctca gtaatttgtc cattttcgat tacaaccgct gcgatttgta 1805461 tgattttatc gcctttcttc ggcgaattcc ctgttgtctc tacatctata acaacgaacc 1805521 gttgcttatt cattaaaatg gacacctcaa ttcttgcata cgacaaaagt gtaacacgtt 1805581 ttgtacggaa atggagcggc aaaaccgttt tactctcaaa atcttaaaag aaaacccccg 1805641 ataaaggggg cttttcttct acaaaattgt acgggctggt tcgttcccca gcatttgttc 1805701 aattttgttt tgatcattca gaacagccac tttcggctca tggcttgccg cttcttgatc 1805761 agacatcatt ttgtaggaaa taataatgac cttatctcct tcctgcacaa ggcgtgcggc 1805821 tgcaccgttt aagcatatga cgccgcttcc ccgtttacca ggaataatat acgtttcaag 1805881 acgtgctcca ttattattat tcacaatttg tactttttca ttaggaagca ttcccacagc 1805941 atcaatgaga tcttcatcaa ttgtaatgct tcccacatag ttcaggtttg cttccgtaac 1806001 agttgccctg tgaagtttgc cgctcatcat tgttcgatac atattatatt ctctccattt 1806061 ctcgaatatc aataatgata ttatctatta aacgcgcttt tgaaaaagca actgcaacag 1806121 cgagaatcat ctttccagca atttcattca caggctcgag ttccggatag gaataaagct 1806181 ctacatagtc tatggttccg ctagtcgttt caatgatatc ttttgcagct tttatcaccg 1806241 cttcaggatc tctttcaccg gcttggacaa gttccgcact tgtttgaagg gcccgataca 1806301 gcttaggcgc ttcttttctt tcctcagctg ttaagtatac attgcgagag cttttggcta 1806361 agccgtcttc ctctctgacc gtatcgacag gaaccaattc aatatccatg aagaagtcgc 1806421 tgattaaccc atcaacaaca gctacctgct gcgcatcttt taaaccgaaa taggcacgag 1806481 tcggcttgac tagattgaaa agcttcgtca gtacgatcgc gaccccgtca aaatgtcctt 1806541 ctcttgagcg cccgcataac acgtctgtgc gtctttctac atgaatcgtg acattctttt 1806601 caccgggata catatcatga gcatctggcg taaaaagaat atcgactccg gcgttttctg 1806661 caagagctgc atcccgctca atatcgcgcg gatatgcttc aaaatcttca ttagggccga 1806721 attgtgcagg attcacaaaa atactcataa taacggcgtc gttttcttgt cttgctttgt 1806781 ctgctaaggt taaatgcccc tcatgcagaa accccatcgt cggaacaaat ccgattgact 1806841 tgccctctga atggtattgt tttatggctt ctttcagctg tgaaatatca gtaatctgtc 1806901 tcatcttatt ttcccccgta caagccgtca agcactgtct ggttcatttg aaaggaatgc 1806961 ttttgttcag ggaaagcacg atgtcttaca tcctgaacat atccgctgat tgctgtttcg 1807021 atggtttcat caatgcgcgt atattgcttt acaaatttag gtgttctctc aacaccgtgg 1807081 ccgataatat catgataaac gagaacttgt ccgtccgctt tcacaccagc cccgattcca 1807141 atgaccggta tgcttagcgt ctcggcaatt ttggctgtga gttctgccgg cacacattcc 1807201 agcacaagca tcatagctcc tgcttcttcg cattttatac tgtcttctat taattttttg 1807261 gcgctttgtt cgtctttgcc ctgtacttta tagccgccca gtacgccgac tgactgcggt 1807321 gtcaaaccta agtgactgac tactggaatg cctccaagcg tcaatgcgcg aatggattca 1807381 aacacgcctt ctccgccctc aagcttcagt gcgtcagctc cgctttcctg aacgatagcc 1807441 gctgcatttt tcagcgtatc ttccttagac aggtgataag acataaacgg catatctgtc 1807501 acaataaagg tattcggcgc acccctttta acggcttttg tatgatggat catgtccgca 1807561 actgtcacac cgacagttga atcaaggccg aggacgacca ttccaagtga atcaccgact 1807621 aaaatcatgt caactcccgc ttgttcagca agtttagctg ccggataatc ataagcggtc 1807681 agcatgacaa tcggttcttc agactccttc atttttagaa aatccagttt tgttttcatg 1807741 ttttctcctc ctcatgttta gaggagatga tctgccgttt tcttctgcaa gccaaaaaac 1807801 cttccgttac aacgagaagg attcttcact ttctaaagtt cggcgagttt catccctctg 1807861 tcccagtcct tttttggatc aaggcagact gctgcaatgt ctatctattt taataatagg 1807921 tgcagttcgc aggcgatact gcccaatgga agtataccaa aatcaacggg cttgtaccaa 1807981 cacattagcc caattcgata tcggcagaat agattttttt aatgccttcg ttcgtttcta 1808041 aaagcagaac gccttcatca tctataccta acgccttacc gtaaaaggtt ccgtttaacg 1808101 ttctggctct catattagtg ccaataccga gcgcatagct ttcccataaa agcttaatcg 1808161 gcgtaaatcc gtgcgtcata taatcccggt accgtttctc aaagcatagt aaaatatgct 1808221 ggatgacgcc ggcccgatca attttttccc cagcagcttg gctgaggctt gtcgcgatgt 1808281 ccttcaattc atctggaaaa tcattaggct gctggttaac gttaatgccg atcccaatga 1808341 tcactgaacg tacgcggtct tcttcagcct gcatttccgt taggataccg actgtttttt 1808401 ttccgttaat caaaatatca tttggccatt taatatccgt ttggatgcct gctgcctctt 1808461 ctattccctg cacaacagct actgcagcaa gcagagtcag ctgcggtgtt ttttggagcg 1808521 gaatgtcagg ccgcaaaatc aggctcatcc aaacaccgtt tccttcttga gaatgccata 1808581 ccctagacat tcggcccctt ccggctgttt gtttgtcagc caccacaagg gtgccttccg 1808641 gtgcgttatt attcgcgagc tcatgagccg ttttttgcgt gcttgaaaga acgtcatggt 1808701 aaataagatg ctggcccatc acttccgttt ttaatccaaa acgaatttcg ctttcactga 1808761 gttttccggg ttttttgatg agccgatatc cttttcttct aacggcttct acttcataac 1808821 cctctttccg aagctcttca atatgcttcc acacagcagt tcttgaacag ccgagagcat 1808881 cactgatttt ttggccggaa ataaattcat tgccggcctg agaaaataat tcaataaggt 1808941 cttttcttaa tgttgaccgc atgtcttcag ccactcctct atgtgtttct tttgattgga 1809001 gagcttccct gtcacaacag cctgctcgat ccactgtaat tcttctgaca cccattttcc 1809061 ggccggccgg tttcgaagcg caagcaagtc cttacccgtg atatcaagat ccttaaggct 1809121 tttgatcggc aggttttgat aagcgtactg aatgtccttc agtttctttt catccagttt 1809181 ttcgttttgc cgaagctgcg atattttggc cgctgagagc agtgcttttt tcccagctct 1809241 gtacattgtc attgcgtcaa ggctctggcc aaacgtatcg gcaatgtgaa tggcttcctt 1809301 gatcactttt cccgggagct tccaggcttt caggaaaagg ggcgcgtctt tcaaaactat 1809361 gccaaggtta attaaaagag cagcccaaag ctcctcacgg gatgttaaag agaagaatgg 1809421 aaactcactc gttgaaatca ggttttctcg tttatgataa aaaccaggaa gctcttcata 1809481 caatctcgtt tgaatgagtg tttgaagcgc ctggcgagaa gctcttccct gcagcaattt 1809541 ctcaaactct atagtttttc gttcgactga aacatgggag aggagtgatt tttctttcgc 1809601 aatggcttct tctgtttccg gtgaaagcgt aaagccaagc tggctcataa agcgtacggc 1809661 tctcagcata cgaagcgcat cctcttgaaa tctatcctca ggctttccaa cggttcgaat 1809721 cactttctga tcaatatctt tcttgccgcc aaaataatca agcaccttcc cgtccgctgt 1809781 catggccatc gcattgatcg ttaaatctct gcgttttaga tcctcttcta atgatgagat 1809841 aaattgcact tctgacggtc ttctgaaatc aacataatca gattcagtcc ggaatgtcgt 1809901 gacttcatag gtttcatcct cccagagcac aataatggtc ccgtgctctt tgcctacatc 1809961 aacagtccgc tgaaacagcc gttctacttg atcaggtgcc gcatctgtcg cgatatcgac 1810021 atctccgatc gttcgtttca tatagctgtc acgaactgcg cccccgacaa aataagcctg 1810081 atggcccgct tcgattaaga tgcggagcac gggaagtgct ttgataaaaa ctttttccat 1810141 gtgatcactc cggttctgct aaatcggcat aaatctgttc atactggctg acaatttttt 1810201 tagaagaaaa ttcattttca agcatctcta ttgccgcctt tgtaaaacga ttgcttagct 1810261 gttcatcttc taaaatgctc atcgcgcggg ctgttgcggc cgtaacatca ccgacatcca 1810321 ccaaaaatcc gctcacattg ttttttataa cctcagggat accgccaatg tttgttccaa 1810381 tacaaggcac tccgcaagcc atcgcttcaa gcaggacaag gccaaagctt tctttttcag 1810441 atagcagcag cttcaaatcg ctaatagaat aaagatcttc aacacggtct tgatttccaa 1810501 gcattaagac ttggtcttcc aagccatatt ttctgataag ctcgcaggct gtcgatttct 1810561 ccggaccgtc tccgactaaa agcagcttcg ctttcgtttt gccagcgata ttgcggaaca 1810621 cacggatgac atcctgcacg cgtttaactt ttctgaagtt ggacacatgg atgacgactt 1810681 tttcatctgg taaaattcca tgtttctctt taattgccgc tgtgtttttc ttcagataca 1810741 cgcgctcgtc tataaagtta taaatcgttt caattttttt ctccggttta attaaatcgt 1810801 atgtttcagc cgcaagcgct gaggagacgg ccgtcaccct gtctgatgac tcaatagcaa 1810861 aacggatcag atcttttaga gacggatcat aacctaacac cgtgatatcc gtgccatgca 1810921 aagtggtaac aatgccgata ttgcgtttca gcatttgttt tgcaagatag gcgcaaacgg 1810981 catgcgggag agcatagtga gcatggataa tgtctaaatt ctcccgttcc gccacctcag 1811041 cgattttgct tgccaatgtc aaatcatacg gaggatactt aaaaacagca tattgattaa 1811101 cctcaacttc atgaaaatga atattgggat gatatgtatt cagtctaaac ggaatgcttg 1811161 atgtgatgaa atggatttca tgtccctttt cagcaagctg cttccccagt tctgtcgcaa 1811221 tgatacctga gcctccaacg ctcggatagc atgtgattcc tatttttagt tttctcattg 1811281 ttcgccccca agcacatcat gatcaagcat cagcatccgt ttggaaaaga aaccttcggc 1811341 atactccacg cccgcttctt taccgtaaag cttttctctc gcttcaacga tttcaatata 1811401 cccattcgtc agaggagtag aaacggaatc ctttgacggg ataaactggc ttttgtaggc 1811461 gttgaggctt tgtttctttg cctctattgt atccgagata tcaataacaa aatccggctg 1811521 atgaaaacca tttatcatat aatagtaaac cttgctgact ttatgcgccg gaaggctttt 1811581 ttcgtcttta tatttatgga ttccggcgga aaagatcgct tcttccacca gtgcagccgc 1811641 attgccgtga tccggatggc gatccttttt atacggcata aaaaccgctt ttggccgaca 1811701 gattctgatg acagtgacaa ttgaccgaat tgcctgatca ctcattatta ggccgcggtc 1811761 tggaagcgtt agctgaattc ttttatctgc gcctaatatg cgggctgctt cagctgcttc 1811821 ttctttacgc aaactgaccg taccgttaga agagagttcc gcttctgtca aatcgcatat 1811881 cattactttt ttttcctgtt tgacaaactt cgctattgtg ccgcccattc cgatctcgac 1811941 atcatcactg tgggcgccaa aagcaagaac gtcagcatta tacattcggc tcttctcccc 1812001 gaagaaggtc acggaattcg aaaacacctt catcaagtgt gcgcacaaga atttccgcag 1812061 tacccatatt tgtggcgagc ggaatggaat acacatcaca taaacggatt aatgccgaga 1812121 catccggttc atgcggctgc gcggtcagcg ggtcgcgcaa aaaaatgaca agatcgagtg 1812181 cattggcagc gatcagtgca ccgatttgct ggtctccccc taaagggccg gattgaaaac 1812241 gttcaatttg aagacctgtc gcctcatgaa ttttcaaccc tgtggttccg gttgcgtata 1812301 gatcatgatt ctttaaaata tcccgatagg cagtcgtaaa ttgaaccata tcctgttttt 1812361 tcttgtcatg cgcgatcaaa gcaattttca ttgtttatcc ccccgtctaa tcaatgatat 1812421 tttctaaacc atacacaagc tgatcaatct tcatgacttg ttcgactgac agtttaacgc 1812481 ctgacatgaa agaagcacgg ttataagaat catggcgtat ctgaagcgtt tggccatcca 1812541 tgccgaacat gacctcctga tgcgcgatca gtcccggaag acggacgctg tgcaagcgaa 1812601 taccgttttg ctccgctcct cttgctcctg ggagaatttc tttttcatcc ggatgtcctt 1812661 gctgcttttc tttacggact tctgaaatca tttccgctgt tttaagcgca gttccgcttg 1812721 gtgcgtcaag cttctggtca tgatgaagct caataatctc aacatcctca aaatagttgg 1812781 cagccatttt tgaaaatttc atcatcagta tcgcaccgag cgcaaaattt ggcgcgatga 1812841 tggctccgat ccctttttct tctgttaaag atgtgagctc ttttaaatca gcttctgaga 1812901 aaccggttgt tccgacaact ggacggactc cgtgctctaa tgcaattttt gtatgtactt 1812961 ttccgatttc gggcgttgtt aaatcaatca agacatccgg ttgtgtttct gtaaaacagg 1813021 catggatatc tgtgtaaatg aaagcatctg actcaacagg catcacatca gataattttt 1813081 gctgatcgta tgtatggtct atggccccta caaggtcaaa atgtggtgtt cgttctgcca 1813141 atttaacagc ttcctgcccc attcttccac gcggtcccgc aatgactaat ttaattgttt 1813201 cgtttgacat cttgatctcc tctactttcc ttcttctttt ctggtccagc gatctttatc 1813261 tcttgtatta aatttatgca tgactcggtc gtgagcttcc tctaaagaga tatcaagaga 1813321 gttggctaaa caaaccaata caaatagcac atcgcctatt tcctcttcca tgcttttatc 1813381 atcttcagtc gctttttttg gtttttctcc ataacggtga ttcacttctc tggcaagctc 1813441 gcccagttct tcagtcagcc tcgccatcat ggccagcggg ctaaaatatc cttctttaaa 1813501 ttggcctatg taacggtcta cttcagcctg tatgtctttc attgttttat cactcactga 1813561 acgaaacctc ctatcatcct cttacatgtt agctaattca gatacgtttg acaaatgttt 1813621 aagcacgttt gctgttttct ttttcatcca ctataatata aacgctatct aatggaagga 1813681 aaaggggttt tgtgtgatgc ttggagaaat tagattaaaa aacatatttt ttattttaat 1813741 cggagcggca attttttcat ttggcttggt tcatttcaat atgcagaaca atctggctga 1813801 gggcggtttt acaggtatta cacttttgct ttatgccctt ttccacatca gcccctctat 1813861 atcgaacctg gtgttgaaca ttccgatttt ttttattggc tggcgtttgc tcggcaggac 1813921 aatgtttgtt tatacccttg tcggcactgt agccttgtct ttgttcctca gcatctttca 1813981 gcgatatgaa atccatatgc cccttcagca cgacttagcg ctcgccgctt tatttgccgg 1814041 cgtattcatc ggagccggac tgggtattat ttttaagttc ggcggtacga caggcggtgt 1814101 tgatatcatc gcacgtttag tgaataagta ttttgggatt ccgatgggca gaacgatgtt 1814161 tgctttcgat gcctgcgtca tcattttgtc tttgcttact tatctctcct ataaagaagc 1814221 gatgtatacg ctggtagctg tatttgtagc ggcaagatta atcgatttta ttcaggaagg 1814281 cggatacgct gctaaaggcg ctacgatcat ctcttcgaaa aacgacctga ttcagaaaaa 1814341 gattcttgaa gaaatggaac ggggcgtcac cattttgaaa ggacaaggtt cctacacaaa 1814401 agaggatata gatgtacttt attgtgtggt gccgaaaaat gaattggtga tgctgaaaag 1814461 cgtgattaac tccattgatc cccatgcctt tgtagcggta agcgatgttc acgatgtgct 1814521 cggagaagga tttacgcttg atgaaaataa aaatccgctt ccgcgctgac atgtaataga 1814581 aaaaaggcgg ctgaccgccg cccctcatcc ttatttaggg tagtcccttt ttttcagctt 1814641 gtttttttcc gccttgtact ttctgtaacc gacataggta agagcagtaa tgatgatact 1814701 gccggttgta atgatcaccc agagtaaaga cggatcggca tcatcctcct ccaccctgtc 1814761 aaacacattt ttcaggtcat gctgaagaag ggaaagccgt tcaagcttcg tgctctctgt 1814821 catttgctga aattcctctt gctcaataac atctatatgt tttccgactg tttcaagctg 1814881 atcctctgat acatcgattg taagactggg gtaaatcaag tcatataaac tgataaattc 1814941 attccatttt tcatgaaagc ttgtgcttcc attcttttgg acatctcgct tcagttcagt 1815001 aaaagcttcc ataatcggtt tttccagtga gccccaaagc gggtcagacc gattgtcaac 1815061 cgcatccatc agcattctga actgcgcggc tgctctgagt ttttgtgtgt ctgatgtatc 1815121 agcttgcttt aaactccgaa ccatatcatt atagcccaat gtgatttgac gaatttgggc 1815181 tcccgttagc atggggtctt gctgtttttt ctcagcggat tttaatgttt tttcaaaata 1815241 ctccaagact tgaagcgcct cttcatattt cgcctgtcgg gtcatttgaa agactgtatc 1815301 ggataaatca ttcaattcct cgaggcttcc ccgctctgca gccttggcat ttccattata 1815361 aaaaataagt gcaatcaaca aacagatcgt cagctttcgt ttcatgcagg tccctcccac 1815421 tctctctcct tacagaatat gaagaaaggg acaaggatag accaacattg tctttacatc 1815481 agctcaagct tcgtttgctt ttttgagacc acaagaaagt aagcaagcgc gattgaaaag 1815541 atacttagcc aaaatgttcc gtatcctatt tcagtcatat aatcagaaag catagagtat 1815601 tgcggcatca tatcaaacaa gtagtcaatg acatcgttat gcagtgtcca gactgcagca 1815661 attgcaagat gccaaaatga aaaacgaaaa tacggactgt ataatacgcc ttgaactgcc 1815721 attgcaaaat gcgaagcaat tagcatgtag ccctcccacg gcaagtcacc agttactgca 1815781 agcacaagaa aattcatagc caccgcccat aggccatact ttacgagggt aactagcgca 1815841 agcgcctcta aaagcggagc attccgtttc atgagaaagg caagcagcac aaacagaaag 1815901 aaaaacgttg ctgtcggact gtccggaaca aaaatcagga aacgggccgg tgtctccaaa 1815961 agctgcggca agtaccaata gtagccgtaa accgttccca gaaaattaat ggctaagaca 1816021 agaataagca tcggccgctg ccctaataca tattgaaacc atttcacatc gaatcaactc 1816081 tcagtctgta aaaataatat gtccatataa aaaagctgac gccgggtcag cttttgataa 1816141 taaaagtata tccttccatt tgacaattca caatacgtta ttttgcggtt gtttcagaaa 1816201 taaattttgc aagttcttcg agctgcttat catttccttt gaacacaccc gccggcattt 1816261 tgcctttccc ttctacagcg atttttttga tttcatccgg tttcagcccg ctgtcaacca 1816321 atgaaggccc ggccgctcct ccctgaaggt tatccccatg gcaagaaata cagccctgtt 1816381 ccttaaaaac cttatatcct tctgcattgg tgtcaatgtc ggcttctttt gtaattttcc 1816441 cctgttcttc tgccttggcc cagtcatgag tagcaactga ctgccacgtc aaaaatacag 1816501 cagcggaaat ggccagaagc atcataccga cagcgaccgg acgcttccac ggccttcttt 1816561 ctgtccctct gtctaggaat ggagccaaaa gcagggcccc aaaagcgaga cctggcataa 1816621 tcatggcgcc gaccactgta aagcttccgg cggcgtattc atacttcaac agctggtata 1816681 agaaaagaaa ataccaatcc ggcagcggaa tataaccagt atcagtcggg tccgccatcc 1816741 gctctaaagg cggctgatgc acaatcgtca aaacgagaaa accgatgaga aagacagctc 1816801 caaccatcca ttcctttaac aagaaatttg gccagaaagc ctctgtttta cccggatact 1816861 ccgaataatc cttcggtata ttcggctttt tttcagccgg tatccttgag tcgcctacaa 1816921 atttcatccc tttgccccgg tgcatgtcat cccctccctt ttattcgcag atcaagagtt 1816981 taaagcggtc ctgaaatccc ctgcttccgg atcataataa aatgtgcagc catcagcccg 1817041 aacaatgcgg caggaagaaa aaatacatgg atcgcaaaaa acctagtcag cgtttgggcg 1817101 cctacaatat ccggatgccc tgcaaggagc gttttaactt gcgttccgat caaaggcgtg 1817161 gcttcggcga tctgcagtcc gacttttgtt gcaaacagag ccttcatatc ccaaggaagc 1817221 aagtagcctg taaagccaag accgagcata acaaaaaaga tcagcacacc gacaatccag 1817281 ttcagctcgc gcggtttttt atacgcgcct tggaaaaaga ccctcagcgt atgtaaaaac 1817341 atcatcacaa tgaccaggct cgcaccccag tggtgcatcc ccctgacaat ctggccgaat 1817401 gccacttcat tttgcaaata atataccgat tcccaggcat ttttgatatc aggcacataa 1817461 tacatcgtta aaaacattcc agataatact tggataacgg ttacaaaaaa cgtcagtccc 1817521 ccaaagcaat acacaaacgc agagaaatga tgggcgggat tcacatgttc cggtacttcg 1817581 tgatcggcaa tatccctcca catcggtgta atatcaagcc gctcgtctac ccagtcataa 1817641 attttgttca gcatgtcacc cttccccctt aggctttgct tttccaagat acaggaagcc 1817701 gtcttttact tcttgctcat aatgatcaag aggcgcaagc ggcggcgtgc cagggacatt 1817761 ggtgccgtcc ttttcataga gtccgtaatg gcatggacaa aagaatttat tcgggttttt 1817821 aggatcacta ttccagttca ccgtacaccc taaatgctta caaattggcg aaagtgctac 1817881 aatttcatcc ccgtttttga agacccaggc tgatcttgac tcttctgact cataccaggc 1817941 atcgacttga ttaattttaa aatcaaagcg ctgcggctct tttgtcaact catcaacgct 1818001 gacaacctga accatatcct gcttccctgt cgattttaat accgggtcga gtgcgaagcg 1818061 aaccataggc atgagcatac tagccgccat aaaacctcct acgcctgtga gcgtataatt 1818121 caaaaattga cgtctggata tatcatgttt tccgcccatc tcttctcccc cctctaagtc 1818181 acccctgcaa actgactaaa atagaaaata ttgcaataac tctagacacc ctcataatat 1818241 atgaatctct cagcaaggtc aatatagcca aaatattgtt tataaggaaa tgtaagtgtt 1818301 tttataaagt gctccataac tgtaacaaaa cgttcaaaat ttcagcagtg cgttcatcca 1818361 atatttttct ttttaaagag tcatttaaat gctctaatgg aacagacgat gtaacaatca 1818421 ttttgcctaa cgcatcctca gctctccaac tttcgtcaga tgtgagcagg acaacatgcg 1818481 gaaattccgt tatcagctct tcccgcaaat ccttaagccc ttgaacggtt atttcatttc 1818541 tatcaacata tgtataaggc ggaagtaaat atacccgtcc ctttaactgc ctttcaagtt 1818601 cttctgagag aagctgcgta aactcgcctt tctccgccgc cattttaaaa tggttattaa 1818661 cccttatgtt aattaatggt atgacagcgg tatcaatgta atccttagct tgtaaatagt 1818721 ccttggcatc agtgattctc cacctcatcg ttctccccct ttacggcaac aagccttgca 1818781 attcactgca aggctggtca tattatgtga gctgatttaa ttggcgcgat aattgttcaa 1818841 atgcctcttt atcatgacga tctaacgcgt cgtcaatgtc ttttaataat ttttctcttt 1818901 ggaatgtgga aatagcgtgc tctaaaatct gttccgccaa tccctgatct tttttattct 1818961 caaaaaggtt tttcggaata tgcgggttgg actccagcac cgccgcatat tcaggtgagc 1819021 tgtaagccga acggaaatta agctggataa acaaatcctg ctgtttattt aatctaatat 1819081 catgaaaaga tttttccgcg tcggtagtca tgacattctc tttatagaac cggaacggaa 1819141 cttcttcaac acaatgtgtt gacattataa tgcctctcgg gcaaaattca gcctgctcca 1819201 caaaatgaac cttctccatg agagaatcat ggctcattaa gtagttcaag atccaaacgc 1819261 actctcggcg ctttaactga taatggttta aaaaccaacg gataaaatct tttttctcat 1819321 tgacagaaac aggggtctgc atgtaattcc ctcctctatc gttcgtataa tctatatact 1819381 tatatgttcc acatgaatgg ttaatattcc tgcttatcta gaaaattcat cctcgattcg 1819441 caaaatcgtt tcttcaagct cttcattggc tccgtccatt tcaagaacct ttttcaaaag 1819501 cggcagcgct tctttttgaa gaccttcttc taataggaag cttgcgtatt catataagaa 1819561 atctctatcc tcccggtaat gaagataggc agcctcaaag gattgttttg cttcctcgta 1819621 ttgctctaat tcagtatatg cgcttgcaag ataccaattg tatttaggat cttcttcacc 1819681 gtagcttcga acctcttgaa taagatcaat gatctgatca taatcctctt ctttgtgata 1819741 cacggcaaga agtgtatgaa gcgcctcgac aaagcccgga tcaagcgcaa gcgcctcctg 1819801 aagcagcttc ttcccctctt ctgacttccc gattttcaag gccattttgg cggcataaag 1819861 gaaaagttct ttgttatatt catcatatct gatcccctct tttgccgttt ttaatgcctc 1819921 ttcatacatt ccttcagctt catagctttt cgagagcggc atataaagtg aagtataaga 1819981 tggatcaagc tcctttaaat cagacagctg cttaatagct gttttcacaa gccccgcctg 1820041 taaggctgta aaaccatagc cgaaaatcgt attaggatca ggattctcat cgacagcttt 1820101 ctcataccat ggaatggcat cctcaaattc acctgaggca cttaacgatt ctgccagtct 1820161 ttgatggaca ttaacgcccc cgatctcact ctgctcctca gccgttgttt taaaatattg 1820221 aaccgctttt gcataggctc cctgagcaaa gtaaagttct cccagtgcaa aatcaataac 1820281 aggttcattg tccagaatgg actttgcctg gaaaagcttt tgttcactga cttcgaataa 1820341 cccctgcatc tgataaagat ccgccataag cagcaaactt tccggatatg atggatctgt 1820401 ttccggaata gtctccagca cagcgagggc tttttcttct tcgtcaatat ctattaaaag 1820461 ttcagcgtag aaattcgtca gttctgtttc atttggatat aaatcatgta gatcactaat 1820521 cagtgaaatg gctttttcta catcgcccca ctcgtaataa agctgggctg caatggcttt 1820581 atcttcatca tgcagctgtt tttcagcctt cgagagcgtg ttgaggcctt tttctgtttc 1820641 acctgcttca actaatttta tggcttcttg aatcaatgta ttcaaatcgg accggtcctt 1820701 tcttttccta tacaacatca accatacaaa aaaagcttta tttgttcggg ttaatcttat 1820761 cataattcag acgaatgccc ccggcaaata agatgcttct gtacggaagg gaattattga 1820821 gtcttattag tttaccaaaa gatcttgaga tagaaaatga aaaaaggaag atcgccctct 1820881 gtacagtaaa gcagctcttt gacctgccgg cttgtaagta aagcacatcc ccccttttcg 1820941 tttttctatc cgttctataa gacaagctat gttttttcgc ctcgaattat gatctgcata 1821001 aaaaatcctg aagtaaaact tcaggatttt ttcgaaagct tatttaaatg ctcgaagaag 1821061 gttggataag aaacgtgaat ggcatccgtg tgctcgattt caatcggctc ctccgttata 1821121 caggaagcaa taccaagcat cattccgatt cgatgatctc cgtggctgga cactgcagcg 1821181 ccgcctttca acgtttgttt gccataaacc ttcattccat ctgctgtcgg ttcaatttca 1821241 gcacccagct tgcgaagctc agaaacaaca gtatcaatac ggtttgtttc tttcactttt 1821301 agctctgccg cgtccttaat aacggtggtt ccttccgcct gagtcgcaag aagcgcgatg 1821361 atagggatct catcaattaa acgcggaatg atatctcctc cgatttcaac tgcctttaga 1821421 gatgacgttt ctataatcaa atctccataa ggctctgcac cgctatcagc agatggtttg 1821481 atttcaagtt ttgcccccat gttttgaagg acatcaataa tacctgtccg agtcggattt 1821541 aaacctacgt ttttcaatac aattctgctg tttggaacca tcgcgccagc agcaaggaaa 1821601 aacgcggctg aagaaatgtc tccaggaaca aaaatatcag cagctgtcag tttctggcca 1821661 ccagcaatgg aaacactcgt ttgatcttca gaaagcttaa cgccaaaagc agaaagcatc 1821721 cgctcagtgt ggtcccgaga tttatggggc tctgttacag ttgttgtgcc ctcagcctgt 1821781 aatccggcca gcaaaacagc agatttaatt tgcgcgcttg caacaggtga tacataatca 1821841 attcctttta atgaagcgcc gctcactgac agcggtgtaa actctccgcc ggctctgccg 1821901 tcgattttag cccccatttt tttcaaaggc tcagtcacac gcttcattgg gcgtttcgca 1821961 atgctctcat ctccggctac cgcgctgtaa aaaggacggc ccgccaatat tccgagcatc 1822021 aggcgaatcg ttgtacctga atttccgaca tctaaaaggc tttctggctc tttcagggca 1822081 tcgattcctt ttccgtgaat cacgacatcg ctgctgcttt gctcaatgtg aacacccatt 1822141 tttctaaagc aatcgatcgt gctcagacaa tctgctcccg gcagaaagtt tttaactgtt 1822201 gttgtgcctg ccgctagcgc gccaaacata acagagcggt gagaaatgga tttatcaccg 1822261 ggaatatgta tttctccatg taaggtctgc accttatctc gtttcatttt ttccacctca 1822321 atcagcataa aaagtttcat attccgcccg ggcttcaatg cattgttctg cccttttgcg 1822381 gtcgtcatca gactgaaaac tgatccttaa aatcccgtta atatcctctc gtgtttcgat 1822441 aatgcggata ttcgtgatac tgatgcgctc cgcagctaag atcgctgtta tctcggatat 1822501 tacacccgga tgatcgggta catccacata taaatcataa aatgcaggta tcgctccctt 1822561 ctgccgaagc ggcagcccgt cgcgataatc cttggctgtt ttaaaataac gaaatagatt 1822621 ttccgcatct tcttgttcta catatgtacg gatcttgtca atttcacgaa tccactcatc 1822681 aaaacggtct aagattttat ctttattatg taataaaata tcccgccaca ttgccgggct 1822741 gcttgatgca atccttgtaa tatctctgaa cccgccggca gcaaaacgct taacaagcgg 1822801 atacaggttt tccgaatgat gggtttggtg aacaaggcta gctgctacaa tatgcggaaa 1822861 atgactgatt acgcttgtaa cgccatcatg ctcctctggc gacatttcca caaaatgggc 1822921 attcgtcccc ttcagcaggt tttttaactg ttccacagct tgtttgtccg ttttctggcc 1822981 tggcgttaaa atataaaatg cattttcaaa caggaactcc ttcgcagcgg ccactcctga 1823041 tttatgtgaa cccgccatcg gatgccctcc gacaaattga tagcggctag gcagcacttg 1823101 atcagcgtaa tcaaccactt tttgctttgt gcttcctaca tccgtaatca aaagctcatg 1823161 ttcaattcct gaatgagcca gctcttcaag cataaccagt gtttgttcaa caggtgtcgc 1823221 aatgattact gtagctgcct ctttcacacc gctaataaac gaatcagcac gatcgtctat 1823281 cacgcctaat tttaatgccg ctaccgcctg ttcatcagag atgtcgattc cgataatccg 1823341 tttgccggga tgattttttt tgatggctag ggcaatcgaa ccgcctatca atccgagacc 1823401 ggcgagcaat attgtatctt tcatttgatt catacgtcat cacctggttt atagactaaa 1823461 gaggtgatat ttgatcacct cttataaaat ttcagctaaa atggcaagta tttcttcatt 1823521 ttgctctttt gttccgatcg taatccggag tgatgtcggg aaacctaatg cgtttcctga 1823581 ccggacgata tagccttttt ccagcagagc ctgaaacagt tcatcagcag gacgtttaaa 1823641 gtcaattaac acaaaatttg tctgtgaagg gtagcacttt aaaccatgag ttttcgcaaa 1823701 atcataatac tgctgaaggc ctgcattatt ttgctcgaca caggaagcaa taaacgcttg 1823761 atcatcaagt gctgcaatcg ccgcagcctg gcccagacgg ctggtattaa acggctctct 1823821 cgccggctca atctggcgaa tcaggttctc gtcagcaatt ccgtatccga ctctgagcgc 1823881 tgccagaccg tatgcctttg aaaatgtgcg caaaatcatc aaattggaat acttgcttaa 1823941 gagcggcacg gtttccgggt aatcctctgc tgttacatat tcataatatg cttcgtcaag 1824001 aacgacaagg acacgagaag gaacgcgctc cagaaatgcg agtaattctc cttcagatgt 1824061 ataagtgcca gtcggattat tcgggctgca tatccaaacg acttgtgtct gttcgtcgat 1824121 ggcttctaac atggcgtcta aatcatgtga gccgtcggga cgaagtgcaa tttcacgtac 1824181 ttcagcacct tcaataaccg cattatgttt atattgcgga aaagtggggg cagcagtaac 1824241 cgtgtttgtt ttatcgttta aaaatgcccg gcagatgatc tgtatgattt catcagaacc 1824301 gttgccgaaa ataagtgatg tttcgctgac attgaggtgc ttactgagcc ttgtccgcaa 1824361 agcggcgcta tacccgtccg ggtaaagggc tagctgttga atctcatgat gaagcgcctc 1824421 ttttgcagcc tctgaacagc cgtaaggatt ctcgtttgaa gcaagcttca caactttatc 1824481 caagccatat tctgatttca ctgcttcaat cggctttcca ggctgataag gcttcagctg 1824541 ttttaaatgt tctttgatac gcaaatcagt cacctcattt taaactgtac aagccgctaa 1824601 acgccattgc ataatcctca aactcctgca gcgcctgatt tctcgtttca gcgctgatga 1824661 gccggtcctt taattcttct atttttctga cgagcgcact tcccactacg acaccgtcac 1824721 taatttcatt catctttatg acctgttcac ggtttgatat accgaaccct acagcaaccg 1824781 gaacagtgct gagattcttc acagtacgaa tgaacgggta cacggatgaa ttgaactcat 1824841 tgcggacacc ggtcacaccc agagaagata cacagtagac gaacccctcg gcttgttcaa 1824901 taatggtttt caaacggctt tcgcttgtcg gcgcaactaa agaaatatac gtcacctcat 1824961 ggcttttaca ttcctcttga aggctgttgc tttcttctaa tggcagatcc ggaacaagca 1825021 gaccgtcaat atgattttcc cgcagtaaag cgaaaaagta ttctttgttc aattgtaaca 1825081 caggattata atacgtaaag aggataatcg gaatattcac tccgtttttt ttcatttctc 1825141 cgcctaattc gattgccttt acgatattca ttccttgatc aagcgcccgc tttgaagccc 1825201 gctggatcac cggaccgtct gcaagcgggt cagagtatgc aacaccaagc tccaatgctg 1825261 tggcgcctgc tttttggagt gacttcgcca gttcaatcga aacctcagga actggatcgc 1825321 ccgccgtaat aaacgggata aacaattttt ctgatggttg aagatccaat ttaaacatgg 1825381 gctttcacct cttcttccaa tacattcatt aatgtgttga catccttgtc tccccggcct 1825441 gataaacaga cgagaatgag ttgaccgcga tccattcctt tggcgagttt gaatgctttc 1825501 gctaacgcat gggcagattc gattgccggc aaaatcccct ctttttctga caaaagcttt 1825561 aatgcatcca ccgcttcttc atcggttata ctgtcataag tgacacggcc gcttttatgc 1825621 aaatatgcat gctccggacc gattccagga tagtcgagac cggctgaaat agagtagggc 1825681 tcaataattt gcccgaactc atcctgaatg agataagtca atgaaccgtg aataacccct 1825741 acggttcctt tcgaaatagt ggcggcatga agaggtgtat caattccttt tcctgctgct 1825801 tcagcgccga tcagttcaac atcttcattt aaaaatgcct gaaacatacc catcgcattg 1825861 cttcctccgc ctacacatgc cactacttta tcaggcatag tgccttcaat acgtttcaac 1825921 tgatccttcg cttcctctcc gatcattttt tgaaattcac ggaccacttg cggataagga 1825981 tgcgggccga caactgatcc aatcatataa aagtgatcct cacaatgctg aacccagtac 1826041 cggatcgcct catttgtggc atccttcaat gttccgtttc cgcttgttac aggcactacc 1826101 tccgctccaa gaagcttcat gcggaaaacg ttcagagact ggcgggcaac atcctcttca 1826161 cccataaaca cagtacagga aaagccgaat ttggctgcaa ctgttgcagc ggcaacacca 1826221 tgctggccgg caccggtttc agcaatgatt ttcgttttgc ccattttttt agcaagcagc 1826281 gcttgaccta gcgcattatt gattttatga gaacctgtat ggtttaaatc ttctcgtttc 1826341 aaatagattt tcgcgccgcc taagtattca gtgactcgat cagcgtatgt taatgcagtc 1826401 gggcgtccgg aatagtcctt taacagctta taatactctt cacgaaaagc gggatcatcc 1826461 ttgatttgtt taaatgctgt ttgtatttca tctaacggct gcatgagtgt ttccggaaca 1826521 aactttccgc caaaatcacc gtatctgcct atttcattcg gatatggata catatcggtt 1826581 catcctttct tctaaaagcc tcatcagatt ctgatctttt tgtccgtttt tttcaattcc 1826641 gctggcaagg tcaattcctt ctggctgcca tttcaatagg cgtgtgatgc tatccggatt 1826701 cacgccgcca gcgataaagc agcgtttacc aatagccgcc tgctgatatt ccggcacaca 1826761 ttcccaagaa aatgcaacac cagttccgcc tctagaccct tttacagatg aatcaatcac 1826821 aaagccgtca acattatctt taaagcgggc tatttcttga gttgtgttat cttgatggtg 1826881 aagcgccttc catatttcac agcctgtcag cttgcgaaga gcagcagcat ccgccggttt 1826941 ttcatcaccg tgaagctgaa tgacgtcgag cttcaagctc ttggcaatac gtgacatcgt 1827001 ctctattgat tcattaacaa aaacacctgc aacctgtttt tcgacacgaa cttggttcag 1827061 ccattttttc acatcttccg gagatacttt tcgtttgctt tcagcaaaaa taaatcctag 1827121 gtaatcagcc tgtgattccg ccgcaagctg caaatccttt agtgaccgaa taccgcaata 1827181 ttttaatgcc ggtttcttca caacctcact ccctaaacaa agcatggatt gctttacgct 1827241 gagaagtttg tctcatcaat gattcaccga taagtacagc tcgtgctcca tgttctttga 1827301 caaatgttaa atgttctaaa gaaccgattc cgctttcgct gacaagcagt gattctttcg 1827361 gagcaagaga tgcgatttgt tctgtctgca tgatagaggt ttcaaaagtt tttaggtttc 1827421 ggttgtttat gccgagaata tcaggcgtga atactttcaa tatttgttct agcgttgttg 1827481 catcatgaac ctccactaac acgtccatct ccttttcacc tgcttcaaga tataattcat 1827541 gaaggtgtaa gggatcaagc acttcgccga ttaacaatat ggcatccgct ccgattcttc 1827601 ttgattcctc cacttgaaga gaatcaataa taaaatcttt tctgagtaca ggtatcgaaa 1827661 cagcgcgctt tacgtctgat aaatagctgt tttccccttg aaaaaacggg gtgtctgtta 1827721 aaacggaaag cgcatctgct ttcgcagttt catagtcttt tgcaatccgc acaggtacaa 1827781 aattctcttt aataagccct tttgacggcg acgctttctt cacttcagca atcaacccga 1827841 taaaccgatt caggcttgcc agcgcctctt taaatgaacg tttttcgaaa ggctgctcta 1827901 ccggcagaac cagtgttttc acttcttctt tcttttgttt gatgattttt tcaagcatag 1827961 atctcttcct ctttctgctt tagtcgttca agctgcgcgg cagcgcctcc gcttgtaatc 1828021 gtctctaacg ccagctccgt tccttccttc agtgaggcgg taattcccgc cgtgtaaatc 1828081 gcagcacccg cattaaaagc cgtaatagat aaagcggaac tgctgctttt attttcaaaa 1828141 atattctgaa tgagataagc gctctctttc ggagactgca cctgtaaatc ttcaagtctg 1828201 ccatttgtga aaccgaaatc ttcgggtgaa acggtatact cccggcgctc tccgtccttt 1828261 aattcaatca cgtcggtcgg tgctgtaatt gaaagctcat ctaaaccgtc acggcttgat 1828321 acaaacataa cgtgcttcgg ctgaaacgtc tccagtgcgc ttgccatcag tccagctttt 1828381 tcaacagaat agaccccaat cacctgacgc ttcgcctgta aaggattgct gagcggccca 1828441 agcagattaa ataccgttct gaaacctagc tcttttctag tacctgctac atgtttcata 1828501 gacgaatggt aaagcggcgc aaaaagaaat cccatgttgt ttgtttcaat gctgcttttg 1828561 accttttcgg gagtggtttg aatagaaacc tctagctcct ctaaaacatc agcgcttccg 1828621 cttttagaag agacagagcg attgccatgc ttagcgattt tcgcaccagc tgccgaggca 1828681 acaattgccg aggccgttga gatattaaaa gtggaaatac cgtctccccc tgttccgcat 1828741 gtatcaacaa tatcaggaag tccatcgact gtaagagcgt gtgcccgcat tgccttcaca 1828801 aaacccgcaa gctcttctgg cgtctccccc cgatgagcaa gaattgacaa tatccccccc 1828861 atttcagaag gagtcatttc cgctgccatc atcatattca tcagcgtttc agcctcaccg 1828921 gcagtaaggg tttttccgtc aacgcacaat tgtagaaatc tgttcatcag ctttatcctc 1828981 cttgctatga aacatgtctt ctgcaatatg aatcgttttc agcagcgcac cggctttatt 1829041 acagctttct tcgtattcgg cttccggaac agaatcagca acaatgccag cacctgcctg 1829101 tatcgatgca acaccgttct ttacactcat cgtgcgaatc gtaatacaag agtcgatatt 1829161 cccgtcaaac ccaatgtagg caatacaccc tccgtatgtc tctctcggtg ttggctcgag 1829221 ttcttgcaaa agctgcatgg cacggatttt gggtgcgcct gttaaagtcc ccgccgggaa 1829281 agcagacatc agtgcatcga caggatgaac cccttttttc aatcggcctg taaccaccga 1829341 gataatgtgc atgacatgtg aaaaggaaac aatttttgtg aactccggca cagaaacaga 1829401 accatactct gctactctgc cgatatcgtt tcgggcaaga tcaacgagca tgtaatgctc 1829461 cgctttttct ttttcatcct tcatgagctc aaccttcagt ctctcatctt cagctttgtc 1829521 tgcaccgcgt tttctcgtac cggcaatcgg atggatttct aagtgcccgt cttgaacgtg 1829581 tattaaccgt tccggagagc tgccgactat ttctctgtct agcagtttca tataatacat 1829641 atacggcgaa ggattgacga tcctaagcac tcggtataac tcaaaagcat ctgcttttat 1829701 cggcacctca aatttttgtg ataaaacacc ctggaagata tcgcctgctt ttatatagct 1829761 tttgattttt tctacatcag ccataaaagc cgatttttca taattagaag atactgtctc 1829821 aaagctgggt gtcttgtatg aatcagcaga aagaaacagc tcttttatgt ttttttggtc 1829881 catcattttt tcaatgagat tttgaagctc cagatgattt tgatggaata catccatttt 1829941 ttcgtttttt gtttcctctc cagtgagcct tgcatattgg ataaagtgga cgtttttggt 1830001 ttcatgatca tacgcaatta atgtccggca aacaaacagc atacactttt ccatgtctgt 1830061 ttctttggta tgcgaaggaa cagaaggctc aatcagcggg atcatatcat agcttaagta 1830121 cccgacagct ccgccgacaa aaggaatgcc aagctcaggt gttttgattt tgtatgtggt 1830181 attcatccag ttcagcactt cttttagttc atttcctgtg taaagagatt tgctgtcctg 1830241 atcagcggcc gaaaaacggc cctgctcttc tttaattgtg agaaatggat tcaggccgat 1830301 aaacgaatat ctggaccaag tggatgtatc gtccttgctt tcaagaagat acgtaatctc 1830361 cctgtcaagc ttctctatca tttgaatggg tgtcagtgta tcgactgtga aggtctccac 1830421 aatcggtatc gtgtggtggg acaagctgtc ctctaaaaat gcggaaatgt ttgattggaa 1830481 attcattgct ctcactcctt atggcaagga gaatgagaag atggcatgag aggataaaat 1830541 actatataac aaataaaccc aaaagaaaga cttcttttgg gtagaataaa cataatgtct 1830601 cagctcaact aaactcattc tctgctaccc tattctctaa ctcaactcat tctaattgct 1830661 ttatacacac tcttgtgtat ttctaagctg ttcttatcgt attacaattc agtatttttt 1830721 gtcaatgata aatcgggcct caatacgaca actttttcta aatatacatg tctgatctga 1830781 tcctgaggga catctgtctg gaccgtcatc atgactctta tgcacttttt cagaccgcct 1830841 gttacgtcca tttcctgcat acatgttacc ggtacatact gccatcctga aagctcgcga 1830901 acagcttttg ccgggaaaac agcgtgcaaa tcaggtgtag ccgacagaag catttgaaca 1830961 acatcttccg gttttgtatg attttcttct atgattttct ctaacagctg tttagttttt 1831021 tgtaaaattt cttcttcagt atcccgttca actgtagttg ctccgcgaat tccgcgaatc 1831081 atcatgatgt ctcctccaat cgccatttgt tcagccagct ctcaagttca tttctggaaa 1831141 atgtatgatc agcaactttc cctaattcgt tgagcacaat aaactgaatc ttcccgccac 1831201 gggttttctt atcattcatc atacggttca agagaaccga agtttccgtc tcttttctga 1831261 tttgacttgg ataacccagg ctttttagcc agctgaccaa acgttttctg tccatttcac 1831321 agcctacagt cttttcgctt atatataaag caaactgcat tccgagggct acggcatcac 1831381 cgtgagtgat ctgcccatat ccatattccg cctcaacggc atggccgagc gtatgcccaa 1831441 agtttaagta agctcttatc ccctcttctt tttcatcctg ctgaacgaca gacgctttaa 1831501 ttgaaatgcc tttaaaaatc atgtcattca gctgatcatt agtgatatca cgcagtgagt 1831561 ggatattcag cagctcctcc agaaacgctc tgtcatagat aaaagcgtgt ttaatcactt 1831621 ctgccattcc ggacctaagc tctttttcag gcagagaacg caggaaatct gtatcataga 1831681 gcacggcttt cggctgataa aacgcaccga ttagattttt tccaagcgga tggttcacgg 1831741 ctacttttcc tccgactgcg ctgtcatgcg ccaagagcgt cgtaggcatt tggatgaaat 1831801 caatgccgcg cataaaagtg gcagccacaa aaccggcaag atcccctaca acaccgccac 1831861 cgaatgcgat gatgcatgag gagcgatcca tatgaaaacg aatcgcttca ctctgcaatt 1831921 ttgtgtacat gtccatggat tttgcctgct ctccactcgg taccgtcact tttttcacag 1831981 gccatttttc ttgcagcaaa tggagcattt catcaccata caggcggtcc acttcttcat 1832041 ccgtgacaaa cataatcctt gttaaaggcc tgtttaaaga ggttaatagt tcgcaagcct 1832101 tttttctgat accttgtccg ataaaaacag gatatgacga ggaagcagtt tgaacatgca 1832161 gtgtcttcat taaaattccc tcgacagttt tctcatattc tccacatttt ctctaatgcg 1832221 gtcaatttga tctaatccga attgttcaac gactgcgttc gcaatttccc aagcgacagc 1832281 cgcttcagcg actacacttg ccgcaggaac agcacagctg tctgaacgtt caatgctggc 1832341 agaaaacggt tctttcgttt caatatcgac acttttcagc ggtttataca aagtcggaat 1832401 cggcttcatg actccgcgga caacaatcgg catccctgtc gtcatgccgc cttccagtcc 1832461 gccaagtctg ttagtagcac gggtgtatcc tttttcctcg tcccaaatga tctcgtcatg 1832521 gacttcgctt ccatttcgcc ctgctgcctc aaatccgatg ccgaattcca cacctttaaa 1832581 tgcgttaatt gacagaacag cggcagcaag cttgctatcc agcttgcggt cataatggac 1832641 atagctgccc acgcctaccg gcattccctc gacaatgact tctactattc cgccgatgga 1832701 atctccgttt gcctttgctt catcaatggc agccatcatt tttttgcctg cctcttcatc 1832761 gtagcatctg acaggagact cttccgttac acgctgcaag tcttcaattg acgtatactc 1832821 tgttttttca gctttaacag cgccaatttg caacacgtgg cccgccacct taatgccaag 1832881 ctcagaaaga atctttttag ctacagcccc tgccgccact ctgacagttg tttcccttgc 1832941 tgaagaacgc tcaagcacat ttctcatatc acgatgatta tatttaattg caccgtttaa 1833001 gtcagcgtgc ccaggtctcg gtctggaaat ctggcgcttc atttcctttt cttcatcttc 1833061 tgtaatcgga gcggcgccca tgatttttgt ccaatgcttc caatcgttat tttcaactac 1833121 gagagcaatt ggcgaaccga gtgtacgtgc atggcgcacc ccgctcataa ttttggcctg 1833181 gtctttttcg atctgcatgc ggcggccgcg gccgtgtcct ttttggcgtc tggcaagctc 1833241 aaaattgata tcttcctccg ttatgtaaag cccggcaggt acaccctcaa taatggttgt 1833301 cagttggggg ccgtgtgatt ctccggctgt taaatatctc atgacttctt ctcccttcat 1833361 cgcattaacg cttttaagta agactactat aacatatttt tcagcaaaaa gtcagtctat 1833421 cttttttgat aaaagaatgt atcggctggg actaggccaa atttctcggg attgaagatt 1833481 tgctcggtgc tgccgacaaa aagaactcca ttcttcttca agctatgtgc catttttaaa 1833541 tacagctctt ccttcgcgct ttctgtaaaa taaataaata cattgcggca cacgattaag 1833601 tcaaagtctt gttcataacg atccgccagc aaattgtgct ttttgaatgt aatattcttt 1833661 ttgatttccg ttttcacttc ataacttcta tttgcgtttt gcgtaaaata acgatctttc 1833721 acagatagcg gcacttcctg taaagaccgc tcctgataaa cgcctttttt cgctttttcc 1833781 aatgcttttt catcaatatc cgtcgctaaa atctgatagc ccggaagacc tttttgctgg 1833841 tccaaaagca tggcaagcgt gtatggctcc tcccccgttg agcaggcggc actccaaatt 1833901 tttaaaggcc tagaggtctt gattaacggc agaattgcag tctcaagaac ttcccatctt 1833961 ttataattac gataaaattc tgaaacattg atcgtcattc tgtccaatgt ttcatttaag 1834021 agagcttgat ccttttccaa tgccgcagca aagtccttaa agctttggaa cccctttttc 1834081 tcataaagtg acgttagcct tctcttcatt tgtgcttctt tatatagtgt taaatcgact 1834141 ccggttaatt gtttccattt cgttgtaaat acgctgtatg tatccatctc tactctccca 1834201 gtctcgctgt ctttttgtcc tagtatagct tgttttatca ggaaattgta ttgtttcaat 1834261 aaaaaaatca gcttttcagc tgattttaga tcgttgggaa aggcagaggt ctgatgcaca 1834321 ctgccattca accctttatt cactttaatg taaaccttta caaaacagaa caaaaaccgg 1834381 cggcgttata tgttgccggc tctgttgctt attttcacaa tgattaatag atccagcctg 1834441 ccataagctg ctgatatgat actaattctt cattcttaaa gaaaatgtta atctcgcgtt 1834501 ctgcactttc gagagaatca gagccgtgga tgatgttttt tccgacaaac atgccataat 1834561 ccccacgaat cgtaccaggt aaagcttctt tagggtttgt tttcccgatc agctgtctcg 1834621 tcacttcaat gacattttcg ccttcccaca ccattgcgaa tacaggtcct gaagtaataa 1834681 actcaacgag ctctccgaag aaaggcttac cttgatgttc ggcgtagtgt ttctcagcca 1834741 tttgttcagt cactctcatt aacttggcgc cagctaattg taagccctta cgttcgaatc 1834801 tagataaaat gtccccaatg agctgacgtt ggacaccgtc tggtttcacc atgataaaag 1834861 tcttttccat catattctcc accccatcat tatgtatgta taggctttca cactgcacac 1834921 cgaaatcgta acatctttct gataattaat caatccgggg cggagaaatt tcttaatatc 1834981 tacaaaaatt aaaattttct tttaccgata tattttgcga tggctgcaag agacgagcgt 1835041 gcgcgccctc gaggaagcgt gtttaatttc tgaaaagctt tctgcagata catttcgctt 1835101 actgccatag atgcttcaat tgcatctgtt tttttgattt cttcaatgat tggttcaagc 1835161 tgttcctgcg ttgtctcact gttaatcaat ttaagctggt tttttaatgc aggatttttc 1835221 agggcataca gcactggcaa tgtgacgttt ccttgaagca aatctcctcc tacgggttta 1835281 cccagctctt cctcagttga agtaaaatca agaatatcat caataatctg ataagacatg 1835341 ccgacgtaat acccaaacca gtacaatgcc ttatgaatct tctcatcagc tccagacgca 1835401 atggcaccaa gctggcagct gaccgcgatc aagagagctg tttttctttt gatacggcgg 1835461 agatacgttc tgagattttg ttccatgttg tatttgtctt tgatctgctc aatttcccct 1835521 agacaaactt caacgatcgt ctgtgacaaa atcctatggg ctttcggttc gttaattctc 1835581 gtcatcattt caagagatcc cgcaagcata taatcgcctg tgtacatcgc aatacgattg 1835641 tcccactttg ctttgattgt cggttttcct cggcgaagct ctgcatcatc aatgacatca 1835701 tcatgaacca aagatgccat gtgaatcatt tccagagtga cggcgacata tttaatctta 1835761 ttaatatcat aatcgccaaa catgccagaa agcagcacga aaacaggccg aatacgtttc 1835821 cctccggcct gcagcaggtg aagacctgcc tcgcttaaaa gcgggtaatc ggaacgtacg 1835881 gtttgttcaa gttctctttc gattacatca atatcgtcat ttaaaaaaga gtaggccatt 1835941 ttaaatttca tatcattcac ccaaacatct gtgttttcat ttccatccga tatgcgtggc 1836001 agcgactccg ccagtaaacg aatgatattt aacatttttc aggcccgcct cttcaaacag 1836061 gcctgccagt tccttcattc cagggaaatc tctggctgat tcttgaagcc aagaatattc 1836121 tttatagctc ttcgcaaaca gtttcccgaa aaacggcata atatacttaa agtacataaa 1836181 gtaagcctgt ctgaatccga acatttccgg ctgggacgtt tccagacata ccacctgccc 1836241 gcccggcttc actacacgtc tcatctcttt cagtacagtc aagtaatcag ggacattgcg 1836301 gagtccgaag ccaatggtga cataatcaaa tgtatcatca tcaaaaggaa gctccatcgc 1836361 atttccgtgc agcagttcaa tttggctgaa tccgccgtct tttactttct gctcgccgac 1836421 actcagcata ttttcactga aatccaagcc cttgatctcg ccgcttttgc ctgccgcttt 1836481 tgcaagagcg atcgtccagt cagccgttcc gcagcagaca tcaagtgctt ttgcgccttc 1836541 ctttacattc atgatgcgca tcgttttgtc gcgccatttt ttatgctgct gaaaactgat 1836601 gacagagttc atttggtcat aatttttata tattttttca aatactccgt gtacgcgctg 1836661 ttcttttgag tcctgcataa tggtttaccc ttcttccact ttctgatgat aggtttgatc 1836721 ttggctgatt gtcttcagac ggtttattaa aatgttctga ataggtgaat ttagaggcag 1836781 aagtgactca atgctgtttt tcgctttttt aaaacaatct tctaatatct cttcttttgt 1836841 ttttcccagc tgtataaaac tgccgatcac atccagaaat gcatcatttc cgttcataag 1836901 ccgcttaaat acaaaaaaat cactcgacag ctttttccag cgcgggaggt tgaagtgttc 1836961 cgccacacga tggaataaag ctgattcaac gatgccgaca ctttcgaaaa aatcgttttc 1837021 gtccttgaaa gaacggtcat acagacgaat tttatgttcg ttgatttctt taatggctgt 1837081 agcaagcgtc cgaatcatgt agatatcctt catttcagat agtaaagagt agtacagccc 1837141 gctgaaataa tcgcccgcga gaacagtcaa ttggcggttt ttgttttcgt ctcgttttat 1837201 gactctagct gtcgtcactt catcatgggt atcaagggcg ctttgtacaa gcatcgctgt 1837261 tacaatataa ttttctctgt cgttgttttt tatgtcggct tcttcaaata aagcatgaaa 1837321 aagaagaagc ttatcctcat caattttcgg cgcagaaata tgcttcgcta aataaggatg 1837381 agacagcttt tgttttaatt tcgtgttcag attggctaaa gttccgtaga tgtcttgcaa 1837441 aaatatcacc cttgtcccca aattcacatt tatttcttaa tctatgtatg agttttatct 1837501 tttcattcgc ttacgcaggt atcattatag cataaaaaaa agaaattggc tgtatcctcc 1837561 cgctgtttgc gagcatttgc ttttaacagc ggggacagcc agcttatttt ttttcgcttt 1837621 tcatttctcc gtacgcggtt tgaatcagtg cctctcctct gactttaatg gcagaagtat 1837681 gctctgtaaa ctgagcgatg atcacttctc ccttgtcgag tttttcggaa tggtgaaact 1837741 ttgtgtctgt tcctcttgtc aggccgatca cattcactcc gtcctcaacg gctttaatga 1837801 cgacaaaatc acttgaatgc ttttggttca tttatagcac cctctatctt tattagtcct 1837861 ggcgtttaat atgttccaat acttctgcac gggcagcggc atcatcttta aaaacgcctc 1837921 tgactgctga agtcacagtt ttcgcacccg gttttcttac accgcgcatc gtcatgcaca 1837981 tgtgttccgc ttcaaccact accattacgc catgcggatc aagcgtttct acgatgcttt 1838041 ctgcaattgt agaagtgatg cgttcctgaa gctgcgggcg ctttgcaacg gcttcaacgg 1838101 cacgtgccag tttgctgagt cctgtgacct ttccgcctcg cgggatatat gcaacatgtg 1838161 cttttccata aaagggaaca aggtgatgct cacacataga atgaaacgct atatctttta 1838221 caagaacaag ctcctcatgg ttttcaccga agatagtctg gaaatgttct tttggatctt 1838281 cattcaagcc ggagaatact tcggcataca tctttgcgac tcttttcgga gtatcaagaa 1838341 gcccttctct attcgggtct tctccgatcg cttctaaaat ttgacgaaca gcttgttcga 1838401 tttgctcttt attaacttct ttcatgttct atgtcctcca ccaatgaata catttaattt 1838461 cgattctagc acatatgccc cgctaaaagc aaagtgaatg ccctgtcagg aagcccatgc 1838521 tcttgaaata tgaaaagccc cttagaaagg ggcttttctg tgaagaaata aagtgtatgt 1838581 aagctagatg catacacgat ctatattcac aattattttc cggcaactgc gtctttaagc 1838641 gctttacctg gtttgaaagc aggtactttg cttgctggaa tttcgatttc ttcacctgtt 1838701 tgaggattgc gtcctttacg tgcagaacgt tcacgcacct cgaagttacc aaaaccgatc 1838761 agttggattt tatcaccgtt tttaagtgca tctaagatcg tatcaaaaac agagtcaact 1838821 gcttttgtag cgtctttttt agacaattcg cttgcttctg caaccgcatt gataagttct 1838881 gttttgttca tgcctttcac ctcctcccaa aaggatacat tcagttcgtt tattatcatt 1838941 tcttcacagt tcagtctgat tctaaacctg tctcagaaaa aaatgagagc aagtaagaga 1839001 aagacaatta aacggctttt taagaaaaac tgcactctga ggaatgtttg tccaacaaag 1839061 tgaagaattt ctgtatgtag agtaacacat ataaaaagcc atatcaagca ttttaaagcg 1839121 tcaatccctt gctcgtcaag gatttaaggt gatttaccga acgaatattc ctttttttcc 1839181 ttttttcatc ctattccttg atccttttcc attattaaga gcaaagaaaa aagacctccc 1839241 attctataaa gaggtctacc ggtattacag gatgatggcg attaagccgc cagagccttc 1839301 gtttatgatt ctttctaatg tttcttttaa tttataccgt gcgttttcag gcatcaatga 1839361 cagctttgcc tgaatccctt ctctcacaat tgagctcagc gaccttccga agatatcgga 1839421 attccagatg gagagcggat catcctcaaa gtcctgcatt aaatagcgta caagctcttc 1839481 actttgtttt tccgttccga taatcggggc gaattcgctt tcgacatcta ctttgatcat 1839541 atggatcgac ggagcgacag ctttcagcct cacaccgaat cgcgagccct gccttataat 1839601 ttccggctca tcgagactca tatcagctaa agcaggcgct gcaatgccgt atcccgtctg 1839661 tttgaccatt tttaaggcat cagacacttg atcatattct gttttcgcat gggcgaagtc 1839721 ttgcatgagc tcaagcagat ggtctcttcc tctgatttcg acgcccacaa cttcttttag 1839781 gatttgatca tatagatgat caggcgcgta caaatcaatt tctgccaccc cttggcccag 1839841 ctcaattccg gctaatccgg cactttcaat gaattcaaac tcgctgaatt ggccgacaac 1839901 cctgtctacg tcccggagcc gtttaatatc cttaaccgtt tccttcacgg actcctgata 1839961 gctttcacgc aaccaatggt tttctttcag caccattacc cagcttggga gattgacatt 1840021 cacttctagc accggaaact cgtagagggc ctctctgagc acactcagca catctgattc 1840081 ccgcatgctc tctacactca ttgccaatac cgggatatca tatttttcgc ttaaatcctg 1840141 gcgcatggct tccgtttccg ggtgatacgg cctgactgag ttgatgacca taataaaagg 1840201 tttgccaacc tctttcagct cttcaatgac tctttcttca gcctctatat agtcacttct 1840261 ggcgatatct ccaatggtgc cgtctgtcgt aatgacaact ccgatggtcg agtgttcttg 1840321 aatgactttt cgtgtgccga tttcagcagc ctcatgaaat gggatcggtt cttcgtacca 1840381 aggcgtattg atcatccgcg gcccgttttc atcttcatat cctttagcgc cgggcactgt 1840441 gtaacctaca caatctacta atcttatatt cacatcgagt ccgtctgaca catgaacaga 1840501 catcgcctga ttcggaacaa atttaggctc tgtagtcata atggttttgc cggctgcgct 1840561 ctgcggcagt tcatcctgcg ctcgggcccg gtctgcttcg ttactgatat tcgggagcac 1840621 cacaagctcc ataaattttt taatgaacgt ggattttcct gtacggacag cacctacgac 1840681 tcctaagtat atatcgcctc ctgttcgttc agcgatatcc ttgaaaatat cgaccttttc 1840741 caagtgatcc cctcccggac ttcctatcct tttcaatttt attaagctct ttcaatcaaa 1840801 cacaggacac tatatgtgta tgacgttgtc ctatttgaat atgacatctt tagaaaattt 1840861 ctcatcctca atctattaat ataaaaaaac ctttctccct atttgtatgc aagggagaaa 1840921 ggttcattcc tttttcatat cattttctaa aaaaacaggt tcctgtttgt catttaccgt 1840981 atattttaca gaaaacgcgg ggacaaaggg ggtttcatgc caaatcatat cctggatttc 1841041 agtcccgggt ttaaacgttt ttttgctttt tttgaggcaa gaagccagct cagtccggta 1841101 atcggcatat atttctccgt ctccgtcaat cataagcggc aaggaattcc ctgagattgg 1841161 gcttgtcact gtaagagagc tgccatcccc aagcttcttc tcatcgagtg taaataaatc 1841221 acgagatagc acatccttgt aaggcggata ttgatgctcc tgacgataca tttggatgcg 1841281 caatttcaca tcgcgaattt tttctgccat ctttagatca attaatttaa cagtcggatc 1841341 gttctctacg tcaacaagca cgtattgata gtctcccccg ctttcaaatg ccgtacttgg 1841401 aggttcagct atgtatcttg gcgctaaccg gttaaagtct atcggatatt tttgatatag 1841461 cggtgtcgac atatctttgg tttgaatagg aagcagccct ccatttgcct tttgaaattc 1841521 atcaacagca gattgaacct gctttagctg gtcttgataa ggaatggcat gcacactgct 1841581 tttccgttca tttggatata aacatccgga taaaaacacg actgccgcaa aaatgattgc 1841641 gcacttcagt ttacccatac agcacttcct tttacagctt tattcattga cagggccgct 1841701 aaaaaccacg acaaacacaa taattccaga tatgagcata cacatgtatg cgaatgatga 1841761 aatcgcaatc ttcaaaaaac ggttttggca cttaaagcgg cttaaataga tggaagctac 1841821 agccagaaac atcagaccca tggaccctag agcaaaccac attttcatca atgccagatt 1841881 caatgacgtg cgcctccccg atatgtaaga tataagcgtt atattatatt ttaatataca 1841941 gcgccggaaa agatcaacca gattttccat ccattgatag aacaaaaaaa ctgaagcaaa 1842001 gagggggacc ttcgcttcag tcaacttgac tatattcacc tgcacgttta agaaacactc 1842061 tcttggactt cgatgctata gtatgcgact tggcatacag atgcatcctc tattgcctaa 1842121 atcggcaaaa tgtttcagga gatcccaaga cttgggtgtt cttctgtttt tcgggctttc 1842181 gttcaattaa gatatgcgat tcaccatttg attgacactt ttacttcact tgattttcaa 1842241 acgtatttac caaatcctcc atctcgtggg ttttccctct cgccattaaa gattcaacag 1842301 cggtttccac tttttgtccg ttgaatagga cctgatggag agcttctgta atcggcattt 1842361 taacatcata tttcttcgaa agctgataag ccgctttcgt cgtgcggacg ccttcgacta 1842421 ccattcccat ctcttcaaga acatcttcaa gcttgtaccc ttttccgagc aaattgcccg 1842481 cacgccagtt tctggaatga acacttgtgc acgtcacaat cagatcgcct actcctgtca 1842541 atccagagaa cgtcaaggga tttccgccca ttttcgttcc gagtctcgcg atttcggcaa 1842601 gtccgcgtgt aatcaaagca gctttggcat tgtcaccgta ccctaaacca tctgtaattc 1842661 ctgcagcaag ggcaataata ttttttaaag cccctccgat ttcaactccg ataatgtcag 1842721 gatttgtgta cacccgaaaa ttgtgattaa taaatagatc ctgcacctct tctgctgccc 1842781 tcatgctctt tgaagatgca gtaacagttg tggggtgccg cagccctact tcttccgcat 1842841 gactcgggcc ggaaaggaca acgatatctt ttctgacatc actcgggagc tcaatttcca 1842901 taatttcaga aatgcgcaga agtgaatctg gctcaatacc cttgctgaca tgaacaaaga 1842961 ctgccttttt cgttataaaa gggacagcct gtctcagcac ttcccgaatt gcttttgtcg 1843021 ggaccgcaac gataatgaca tctgcgtctg aaacagcctc tttcatatct gttgttcctt 1843081 taatggatgt agacagctta acattcggca aataatcttt gttttcatgc aactcattaa 1843141 tttgatgaat taaatctgca cggtgagccc acacacacac ttcatttcca ttatcagtta 1843201 gaactaaagc cagtgctgtt ccccaactcc ccgctccaag cattgtgact tttttcatgt 1843261 ttgattcaca cctttttatt ttctagctct tgcaaatatt ttgattggtg tcccctcaaa 1843321 accgaacgcg tctctgattc ggttttctaa aaaccgttcg tatgaaaaat gcatcagttc 1843381 cggatcgttt acaaacacaa cgaagcttgg cggctttacc gacacttgag tcgcatagta 1843441 aattttcaaa cgagaaccgt tatgagtcgg tgtcggattc attgccacag cgtccatgat 1843501 gacatcattt aagacgtttg tttgaactcg aagtgaatga ttttcactag ctttgataat 1843561 cgcaggcatc agagtatgga tccgtttttt cgttaaggca gacataaata ggattggcgc 1843621 ataatccaga aattgaaaat gatcgcgaat attttcttca aattctttca tcgtgctctc 1843681 atctttgtca acagcatccc atttgtttac gacgatgacg acggccttgc ccgcttcgtg 1843741 tgcataaccg gcgatacgct tgtcctgttc aataatgcct tcttcgccat ccagcacaac 1843801 cgccacgact tctgagcggt caatcgcttt tagcgcccgc agtacactat acttctcagt 1843861 cgtttcatag actttccctt tttttcgcat acctgcagta tcgacaatga caaactcctg 1843921 ctggttgtaa gtaaatgacg tatcaacagc atctcttgtc gttccagcca cgttgctgac 1843981 aataacgcgt tcttcgccga gcatcgcatt cacaagtgaa gactttccga catttggacg 1844041 tccgatcaga cagaattgaa taacttcttc attgtatttc gtttcaggaa tgtttttaaa 1844101 atgctctgca acggcatcca gtaaatcacc cagtccgagt ccgtgtgttc ccgaaattgg 1844161 atacggctcg ccaaagccta gcgaataaaa atcataaata ttcgctctca tttctgtgtt 1844221 atccagttta ttaaccgcta aaacaacagg cttttttgtg cggtacaaaa ttttcgccac 1844281 ttcttcatca gcagctgtca cgccttcacg gccgttcacc ataaaaataa tcacgtccgc 1844341 ttcatccatg gcgatttcag cttgctggcg aatctgcgct aaaaacggct catcaccgat 1844401 atcaataccg cccgtatcaa tcaaattaaa atcataattc agccattcag ccgagctgta 1844461 tatccgatcc cttgtcacgc caggggtatc ttctactatt gaaattcttt ctcccgcaat 1844521 ccggttaaag attgtggatt ttcctacatt tggtctcccg acaatggcta cgacaggttt 1844581 acccatagta cccttccttt caatccagcc gctttcattt ttacataaat tttcaaccgg 1844641 ttattaaaat catttcattc acttttatga aaagaaaccc ttcagaggaa gggcttaact 1844701 catttattat atcagttttt actgggatca caactattct taaaaatgtt tcacgatcaa 1844761 atacacgtca tctccgattc tgtgagctat tccatcaagg atcgcctcaa gatttttagc 1844821 gaaaagctcc atctcctttt ggtcattgca aaaaaagaca ggtgctcccc ctgcaacccg 1844881 atttcgattt gtcgtgatta cagacaaaat cactttcgta agagattcac tcatcctatc 1844941 accttatcct gattcttgat aaattcagtc ggcattctaa tcgcattttc cagggttgga 1845001 acattgctaa taatttgaac agccgtttcg ggatggtgaa tttgcgggag aacaaatact 1845061 gccactctcc catcatttaa atcccgtttt gcaattggtg tcaaagatgg ctctcctgaa 1845121 tcccgataaa ccccgagcac attggaaaca tcaaataaaa tggcctgacg ctgccctaaa 1845181 tttgctatcg tcgctgctga attaaagttt ttcggcgtca aaataaagcc catgccatgc 1845241 tttaaaatca gttcctgttt ctctggaagc ccgatattca tcatataaat attatcaaca 1845301 aacagtcccg gaccgtcaaa gcgcggcttt atgtactcga tatctacaat atccttcaac 1845361 acactgcccg acataaactt catggccagt aaaaaacaaa cgacagccgc tatgactgca 1845421 gcccagatgg ataaaaacac atacgcagag gttgtcaaaa gcgctgtaaa gatcacaata 1845481 taatttctgc tttcaaacgc aatggcaatc ccctcaatat atgtgcttcc ccttgagaca 1845541 agttcatacg aatccatttg cgtcaatgtg ttccgctcca tgtttcggac atctctaaat 1845601 tgcgtcgctg ccaatgttaa aaatgtgatg gccgtaaatt cctcctgcaa aagcgccggc 1845661 ataataattg cacctaaacc agccgctatc aaccccagtg cgatgtgaat cactttccca 1845721 tgaacatagg tcggatactg gcggtaatcc gttttcagca tataaagcct tgtcgcaatt 1845781 ccggcaatga ccccagcaat aatcggatag atgtaatcac tcatgacatt ttggtagctc 1845841 ctttgtttga tcttttgctt ttctgaccaa tctggcttgc gaggtgttcg tatttagata 1845901 tgccaaacag caatatcatc cccgcagaac acgcattcag ccattgaaag ccgccgacag 1845961 ccatagcccc ggccaacttc tggatcacaa atgaatacac cagttcgcct tggcacatcc 1846021 ctaggacaaa taagacaagc tgcttctcaa aattcctttc aacagaagct gttaaaagca 1846081 ctattaatat aacagcagcc cactcaggtt ttatgatgaa ccaaaccggg tcatataatg 1846141 caaaaagata aacaaacgca tacgcggcaa caagcgtcag atagaccatg atgtaacgaa 1846201 aacgatacat tcccaaatac ccggcataga cacatccgca aacgaaaaac atcaaatatg 1846261 cagcattcag ggaaaaatat aaagcgatgt catgtatgct tagaataata ttagttaaaa 1846321 taaagacaga gacggcaatt cgtcttttcg tcttttcaaa aataaatgtt gtcagaaccc 1846381 acagaaacca cattgaccaa tagtaataaa attgttccat tttacttcct ccatattccc 1846441 agtatggagt tcaagcacat tttttaaaca atcgatctca cattaaggag tatgatcatg 1846501 ggaaaagaca gacaagagaa aaaactcaaa gcttcaggca gagtcgaatc agatcgcgac 1846561 cagtccattc actatgacgg agcgacaagc cttgaacaaa acggaagatt caaaaagcga 1846621 aaatcataat acaaaaagcc caaaccacat atggttttgg gcttttatca tttatcgcac 1846681 actatagctt gatgtattga cccctctctc tgtgagccaa tgatgggttt cacctttgat 1846741 cacaaggggc gccttttgta aatcggcaat tgttctggca cccagcacgg tcataatcaa 1846801 ctttaattcc tcaaggatca gctgaatctc ctcaagcagt ccttcctcac cgctgtcagt 1846861 cagcgctttt aaaaaatgcc ctgccattcc ggtgcaagag gcccccagcg caattgcctt 1846921 tgccacgtca agcgcatctt gcagaccgcc agaggcgatc atggtgcttg caggaaactc 1846981 agagcggatt tccgccaaac ttgcagctgt cgaaatgccc cacgaattaa aaaaggagat 1847041 ttgccgctgt cttcggagat tttcgatttt cgagaaattt gttcccccgt aaccgccaat 1847101 gtcaacagct gcagcaccag cttcatacag ctttcctgct gatgctttgc tcataccgaa 1847161 gccgacttct ttcacaatga ccggtacact gacccggctg caaatttgtt caatgcgttt 1847221 caatgcgccg ctaaagcttc tgtccccttc aggcatcaca atttcctgaa tcacattgag 1847281 gtggatctgc agtgcgtttg ctccaatcat ctcaacggct tcctttgcct gagcagccgt 1847341 tgcctcgctt cccaggttgg caaaaatcag cccgtttggg ttttcctttc gaacaatttc 1847401 ataggaaaga cgctctgatg gatcttttaa tgctgacatt tgcgatccca cagcaagggg 1847461 aattccagcc tgagaagccg ctcgcgcaag cgatttatta atctcatatg taagttttcc 1847521 gccgccgcca gtcattgcat tgataaaaat cggcgaactg cttgaaagtt cgccgatttt 1847581 tgtggaaata tctacttgtt ctaatgcaag atcgggcaga ctgacgtgaa caaacgtaat 1847641 atcatcaaga cctgtttccc gcttctggcc gatggacaag gcatgattga tgtgttgtct 1847701 ttttcgttct gctcgagtca cgtttatcac caattatttt agtttattca gcttatctcc 1847761 gatcagatct ccaagctgga agccagtgct tgtttcttcc ttcgcttgat attgacggta 1847821 atcttcctgg tcagctttag gcgtttcttc aagttcacgc atgcttaatg aaatgcgctc 1847881 ctcattttca ttcacatcaa gaaccttcac ttttacagtc tgtccttctt caaggacttc 1847941 atgcggcgtg ccgatgtgtt tattggaaat ttgagaaata tgaacgagac cttcaacacc 1848001 tggaaggatt tcaacaaagg caccgaagct tacaagacgc tgtacagttc cttcaagcac 1848061 atcgccaggc ttcacttttt cgccgatttg gttccaaggt ccaggcagtg tatctttgat 1848121 cgataaagaa atacgttcat tatcacggtc aaccgataac actttcactt ttacttcttg 1848181 tccctcttca acaacgtcag acggcttctc tacatgagag tgggaaagct gtgaaatgtg 1848241 tacaagtccg tcgatgccgc caatatcaac aaacgcgcca aagtcagtca ggcgctgtac 1848301 tttgccatca agtacacttc caacttcaag agactgaaga agttcttgtt ttttattcgc 1848361 ttgttcactt tcaacaacag cacggtgtga aaggatcacg cggtttttat cacggtcaag 1848421 ctctacaacg agcagtgaca gtgtttttcc tttatagtca gtgaagtctt caacgaaatg 1848481 tgcttcaaca agtgatgccg gaataaaacc gcgaacgccg atatcaacga caaggccgcc 1848541 tttcacgaca tctttcactt cagcttcaaa cacttctttt gtttcaaatt ttttctcaag 1848601 gtcttcccaa gcgcggtctg catcaacagc acgtttagat aaaatcaaag catcgtcttc 1848661 cacttttgtt actttcaggt caagctcgtc gtctacttta acaacatccg atgctttctc 1848721 tacatgaaga cttgataatt cactgattgg aataataccg gattgtttga cattgataat 1848781 ttctacatct acatgtttgt cttctacctt tgtcacaatc cctttaacta catctccaac 1848841 ctctggcact tgaacatcaa tttgattcat ttcctctgtc atttgaataa cctccttggt 1848901 ccaaacctac acagcttaat taaaacggtt tgaaagctga acatataaca tgcccgcttt 1848961 tagccgaata tgtattaaag aatcatccaa aaaagttttt tgaatgatca ataaaaagtt 1849021 ttattagtat taacttctaa taaaaggaca ggtttgtcaa gcaataacat tctatcttcg 1849081 ttgaaaaatt caaaaaaagt ggcatttgcc atcctcagcg ggacttttgc tccacagcct 1849141 cgaggatttt atcagctacc tcttgaatgg aaagcgatgt cgtgtcgatt tcaagagcgt 1849201 cttctgcttt acgcagcgga gatacttcgc gctctgaatc aagcttgtct cttcttgcaa 1849261 tttcctcaat taatgtttcg tagttgacat caaagccttt tttcacattt tcttcataac 1849321 ggcgtttcgc tctctcttcc acagatgcca aaagaaagat ttttacttct gcatttggca 1849381 gcacatgcgt cccgatgtca cgaccatcca tgacgacgcc gcctttttcc ccaagctgct 1849441 gctggcgttt caccatttct tctctgacac ttctgtgctt ggccgcaatt gaaacttggt 1849501 tgctgatttc atctgttctg atcgcctcag ttacatcggt gccgtttaca aacacttttt 1849561 gtccatcttt tgttgtaatc agctcaatgt ctgtccgctt tagcagctca gccagttttt 1849621 cttcatctgt cagatcaacg ttttcctgta aagccgcgta cgtaatcgcc cgatacatcg 1849681 ctcctgtatc aatatatatg tacgattttt tctcagccac aattttggca acggtgcttt 1849741 tccccgcagc tgccgggccg tcgattgcaa tcgataattt cttttccata attcctctcc 1849801 ttgctctttt ctcctctaag gattgtatca cgaactttat gaaaaagggt gaaaaattga 1849861 tgaataatta atgtttgaag gtttcaatcc tattgttttc ctccatttta tccacccctt 1849921 catattgaat cacttttgat acgtatggtt caatatgctg atagtgaaaa agaaattgga 1849981 caccaagtaa aatgatggcc tgaatgaaca ataatttgat cagcagccgt tcaaatgttt 1850041 tcattggagc acctccatta caaatagtat ggaagtgttt gccgatgttt attccattcg 1850101 ggcctttctt ctcttattta actggcgcct gatgcagtat tgaagcaaag cctgctggtc 1850161 acctgctgca atttctgaat actctaaagt catttttcgt ttttctgact tggggtcatt 1850221 aaagattcgt ctgacaactg cttctgtttc tatttgacgt gtgtgctcct cttcaggaag 1850281 acggatgatc aggcgcaatg attcccccga ttgaaaagaa aggccatcag ctaaaaccac 1850341 ggcgatgccg cctgcactga tgttatagga tagtgtgcgg atctcttctt catttcccgg 1850401 ctgaatttgc acatctaata ccgcatcagt tcttacatat tggcggcgct ggattctttt 1850461 cattttttca cggggaggca tttcaagaca gatcatttga agtttgtcct tcactttacc 1850521 ttttatacgg cttataaagc gataaggaac ttcgtctttt cccacaaact ctaccgttac 1850581 ttccatatcg ttatgtaaaa tcacagttcg ccctgtaact acatcaacag gatacgcgat 1850641 caaaagttca ttgttttcga tgctgaccgc cttgcttttt gcctttttca attcattttc 1850701 ttctatatat tctaaaagta cattttctcc aatctctatc attgacttca ctctttcgca 1850761 ttcaatatac tcacgttttt attaaagcac gtaatgaaaa aaaggaaaag acatttagtc 1850821 ctttcctcct gtttttatag gtctttatat ataggttctg cattttttag tttttcaacc 1850881 ttttcttccg atccgtcttt ggcattgata tacattctga atgtgtcatt ttcaattgtc 1850941 ccaagcattt cgtagcataa cacttcttga cctagttcat ttgtaatcaa agcgagcctt 1851001 gtttctctca cttgtacatt tttatttaat ttagactttg cctctgcttc agtaattgca 1851061 ggcttaggta tggttctttt tctgtgagat gtgaggaagt ctcttgctga aaagccgaca 1851121 acctcaccgt catccaaggc cactttcata cgaattgcct cggggtacat ccggacttta 1851181 ttttcaacag gaacatatga aaatacaccg attttatcat attgggcact ttcatcaatt 1851241 tccaaatcat ctgtttcaaa tccgtttttc tttaaaaatg caagcgctcg gttcgatccg 1851301 tcatttaaac tgattttctg atctttcact tctctgtttt ggatcaagta taccggatgc 1851361 ccgcccttct tcgtaatatc catataaatc actgctttat ggtctgggtc tttcatgctg 1851421 atgctatata catcgcgatt tgtttttttt ccgctcttta ccactttaat tgaataattg 1851481 tcatctgggg caaagcgctc agcaatttgt tttgcttcct gttcggaaat ttgttttccc 1851541 ttcagatggc tgaagccttt ctcttctttt ttcgtactgg tgaaactcgg gccaagatca 1851601 gtgccagtgg agaatgcacc aacatttttt tcgactgttt taaagctgtt gataatcgta 1851661 ttatcacttt gtttttcgtc agaagccaga gccatttcta cgtccatcca gcgaaggttt 1851721 ttgctcatga caaggtgctg aacatgacgc aattcatttt gtatatcttc ggactgctga 1851781 tatagcttat ttagtgatgt atactcgttt ttatcaagcg gcttttggtc caaatctctg 1851841 actgacgttt tatagctgaa atcgccgatc tttgataata gctcttcagt tttattaaac 1851901 ggcattaatg taagcggcag ctgactgacg ctgttatgag cttctgatgt aatcctccac 1851961 acatcgatca atgcaggcga cagtgatttt tggctgttca tggcaagtgt tgttccgatt 1852021 ttatcatgaa gctgatccac ctgataggta agctcatgaa acgcccgctg atagttattt 1852081 tcagcatgaa gaagaactgc gtctttttcc tggtgttctt tgtatcccca gtagcctgta 1852141 ccgactattg caataccaag cacggcgatt aaaattcctc tgatcattta tcacacctct 1852201 ttttatgctt tctcatatct gctactcaca gaaaatgtgt ttaccgattc ttttaatctg 1852261 cggacgcccc caaatccacg gacttgtagc cgtatccgga ttaaagtagt aaagtgcttc 1852321 ctctgatggg tcccagccat tgatggcatc cagcactgct tctcgtgccg tttcattcgg 1852381 ctgcatgtaa atttgtccgt cggctactgc tgtgaaggca agcggctcaa aaataacccc 1852441 cgctactgaa tttggaaata acgggctgtt caaacggttt aaaatgactg ctgcaatagc 1852501 aacctgcccc tcgtacggct cgccccgggc ttcgccataa accgcttgag caagcagcct 1852561 gatatcgttg ttggaaaatc caccaggcat gttcgctgct accgcatcct gttttcttgc 1852621 ttttgctggt gtattgtttt gctgtttatt cgcattcgct ttaggcttct gcgttgtttt 1852681 ttccgcaggc tgtttctgcc gtgcttctgc ttgttgtctt gccttttgtg ttgctgcttt 1852741 tgatggtttc gtctgatact ttagcggaat ttttccgtaa tgcgtgaatg tattcccttt 1852801 attgagctgt tccatgacat attcacgata gtattttgat ttacatatta aggtttgctt 1852861 tgttttagct cctacaaggc cgtcaacctc ttttaacccg aattgatcct gaaaatttcg 1852921 aactgcccag tacgtccccc atccataaac cccgtcaatt tttccgttat aatatccgtt 1852981 gtattgaaga cgcgcctgaa gctcgaccac atcatcccct gttgcccctc tttgaatgac 1853041 ctgattcgaa aaggcagaga tcgtttcagt attaataaac gtcgttattg taaaggaaaa 1853101 aaggatgaga catgccataa tcgatccttt ggacttcatc ttttcaagcc tcctactgca 1853161 aatttttaag tgtaatcgta ttttctgtaa cgaggttatt tttatacact ctttccttgt 1853221 tatccctcag aacataaaaa ctgcacacaa aaaagccgca cggttgctgt gcggcttcta 1853281 tacttgcatc atattaacgg aacgggcttt tttcgcttta cgcaaaccaa accaccataa 1853341 aaataccata aatggaagca tataataaat ccaattgcta agcgctgtta ggataaaatc 1853401 atatgatcca tgcaaaaggg atgggacaac taaagaaaga gtaagccact ttacacgcgc 1853461 cttatcagcg gaaaaacggg cttttccaag gtaaaatccc attataacgc caatcaaggc 1853521 atggcatgaa acaggcagca gcgccctgac aaacgcatgc tccacgccgt ggccaattaa 1853581 ataaagaata ttttcgaggg ttgcaaaacc gagtgataca cttgcaccgt acacaatccc 1853641 gtcataatgc tcatcaaagt gggcgtgcgg gtaaacactg atcatcagta taaaccattt 1853701 taatgattcc tccaaaaacc ccgaagataa aaaagaaacg aaaaagcttc cgcctcctac 1853761 attctctttt tcaagtacat actggataaa catgatggga aatacaagaa caaccccgag 1853821 aaaaaacgac cgtagcacca tatgtacagg ttcattatca tactgatctt ttaaataaaa 1853881 ataacttaat aacgcgatgc cgggggcaat tcctgcagag atgattgcaa acatcaggca 1853941 acctctttcc tttatattcc tacatctatc ctaccatgtt gtttaaaatt ttacatctgt 1854001 ctgcacttaa aaaaacaaaa agagcatacg aatgcatcat atgctcctca tctttaatgg 1854061 ttttctcttt tggcgatttc cgctgcgata tgccccccgt gaaacctgcc gttttcaata 1854121 aatatttcat ttgcattgtt tcccgcagca ataacaccgg caataaagac accttcaacg 1854181 ttcgtttcca tcgtttcttc gttgaaaaat ggacgccctg tttctttatc aatttcaaca 1854241 ccaatttttt caagaaattg atgatcggga tgatagcctg tcatggcaaa tacaaaatca 1854301 tttttaatgg taatgagttc tttctctccg gagcgaaaca caacttcatt ctcggtgatt 1854361 ttttcgacac aagctccaaa ttccatacgg attgtaccgt ttctgacgag agcttcaaat 1854421 tccggcagaa tccacggctt aatgctcgga gaatactcat tgcccctata taaaactgtg 1854481 acacgcgccc cagatttcac gagttcaagg gcggcgtcca cgcttgaatt tttcccgccg 1854541 atgacaacaa catctttatc aaaatacggg tggccttctt taaaataatg aaatactttc 1854601 ggcaaatcct caccgggtac gcccatatag tttggatgat cataatagcc tgtggcgatg 1854661 atacaatatg gcgtcgtgta ggtctctttt gacgtctcaa taacgaatgt gttattttgc 1854721 gttttcgtca ctttacgcac catttcaaac gcattaacac ggatgttttt ccgtttaacg 1854781 acttcccggt aatacgataa agcctgaatt ctgacaggct tcctgttctc tgtaataaat 1854841 gccacatctc cgatttcgag cttttcactt gaactgaaaa aggtttgatg cgtcgggtaa 1854901 ttgtaaatac tgttaacgac attgcctttt tcgatgacga gggcatcaat gccaatttgt 1854961 tttaggtgaa tggcagcaga tagtccacaa ggtcctccgc ctataataat tgctttttct 1855021 tgaatcattt ctgtcaactc ctgcgattgg catttcactt catattttct atttccgaat 1855081 aaaaaaatct cctattttat cataggagat tttttatttt tatgcaaatc atcaacttat 1855141 atccagcctc taaaacgcga agcttcagcc attttgcgaa cgccgaccat atatgcagcg 1855201 agcctcatgt caattcttcg gttgttagcc atttcgtaaa tattgttaaa tgatttgacc 1855261 atcatttttt ctaatttttc ttctacctct tcttcactcc agtagaagcc ttggttattc 1855321 tgaacccatt caaaataaga aactgttacg ccaccggcac ttgccagcac gtctggtaca 1855381 agcagaatgt cccggtctga aagaattttt gttccttcaa gcgttgttgg tccgttcgct 1855441 gcttcaacga caattttagc ccggatatta tgggcatttt cttctgtaat ttgattttca 1855501 atcgcagcag gaacgagaat atcacaatcc agctccagca gctcttggtt ggtaatggta 1855561 tcgttgaaaa gctttgttac ggtaccgaag ctgtcgcgtc ggtcgagtaa ataatcgata 1855621 tcaaggcctt ccggatcata aagtccgcca tacgcatctg agatgccgac aacttttgcc 1855681 cccgcatcat gcataaattt tgccaaatag cttcccgcgt ttccgaagcc ttggacaacg 1855741 acacgcgcac ctttaatatc gatgcctctc ttcttagccg cttctttaat acagatggta 1855801 acaccttttg ctgtcgcaga ttctctcccg tgagatccgc caagcacaag cggtttgcct 1855861 gtaataaatc caggcgaatt aaattcatca attcttgaat actcatccat catccaagcc 1855921 atgatttgtg agtttgtaaa tacatccggt gccggcacgt cttttgtcgg gccgacaatt 1855981 tggctgatcg ctctgacata ccctctgctc agacgctcca gctctctaaa cgacatatcc 1856041 cttggatcac aaacaattcc gcctttacca ccgccatatg gaagatcaat tatgccgcat 1856101 tttaaactca tccaaattga aagcgccttc accgccttca cctctttttc tgttacgttc 1856161 gggtgaaaac gtatcccgcc tttcgttgga ccgacagagt cattgtgctg cgcacgatat 1856221 cctgtgaaaa tctttactga accgtcgtcc atacgaacag gtatttttac cgttaataat 1856281 ctcatcggct cttttaacaa ttcgtatacc tcttcgggat atcccaattt ttccagagcc 1856341 ttatgtatta cggtttgggt tgattttaat acatcaagtt tgtcctcttc tgtatgaccg 1856401 gtgtttcgat cggctgccat ttgagttaac ctcctagaat cttctgtttc tcacatgctc 1856461 cctttcagag aatagtatac accttcatat gatctgtgca tagaataaac gttatgtttt 1856521 tccatgtttt ttaacgaaaa aaaactgctg aaatcagcag ttttccgttg cattcttatg 1856581 aaaaatgagt ttgtatcgtt tctacggcat taccgtccat aatgagctta ccatactctt 1856641 gcaggcgata aatcgttaaa gttgtcggat tgccgtattc agccagaacc gccacaaccc 1856701 cttcagccgt atgtgaccct agatcttcaa ggcttaaaaa gtactgcccg tcatagtggt 1856761 agacagttcc ccctgtgata ccgattcgct gtaagctttc tgaaagctga atgatatctt 1856821 caaaggaatg gaattgatat atgatgtccg cgctttcatc aagcttgact tgcatttcga 1856881 tgtaatcatc atcatactca tcgtcttctg aatcggcgtc ttggttcttt gttacaatca 1856941 cgaccatccc ttgtgcttgg agagaataca cttccactgc aatcggtcca ttcgcttcaa 1857001 agccgagctc tgtatttgct tcattcatca tatctttaaa taactggtgg actttaaatg 1857061 agtccttcca gaggtcttct tttgtcaatc cccggtctgt caaatcatcg agggttaaaa 1857121 agattttgat cttattataa ttcagacgct caagccgcat aacgttccct cctgcctcta 1857181 cttgcacaca aatcatataa cacattatat gagatgatga gtcataggtt cttaattgtt 1857241 atcagtttac actgagttca ctagtaagac aagcacaatg cagtttttat tgccatacgg 1857301 atttttgctt tttagaagtt attctggccc gcaaagagtc acaatgtgag tttcaggctc 1857361 agcacctaaa cgaagaggca cttttgtcgt gccgtagccg ttgctgatca gatatgccgc 1857421 gtttttaaca atacctgttt tccccagttc ataaggaccg aattttccaa acctgatctg 1857481 gcctccatgg gtatgtccgc tgagtatcac atcaataccg tcatcttcat tgatttgttc 1857541 atgaatctcc ggattatggc aaaccagaat attcagctgg ctttcatcaa gttctttgat 1857601 ggcttcctca taatgatcca tctccatcct gatatcatca acccccgcaa tcgcaatcgt 1857661 atgcccattg tatgaaaacg ggactgactc atttctcaga gtgatgacgc cgtgcgcttt 1857721 aaatatggaa tacagcttat gctgcctgac ttcataatca ttattccccc acacaaacac 1857781 gatagggacc ccgaaatgta cgagcctttt gatgttttcc tcgattctcg cactgggcac 1857841 cccgccctca gctaaatcac cgccgattat aaccaagtgg ggggcatggc ttcgcgcttt 1857901 ttctaaaagg tcttgatcga tgagacgttt gtgaatgtct gaaataaaaa agattgtcag 1857961 aggcggcttg cccttcatct ttgataaagg aaacgtatgt gtcttcaaat gattgccttt 1858021 tgctgttgca tacatttttg ccgtcattgc cgctgccgca acagttagta caccggcaat 1858081 tttcactgat agcttcataa aaaactctcc attcttttta gaacttatca ataagacgga 1858141 caataaaaaa agacgtttct atcgtttgag aaaacgcccc attttattta ctttcaaaat 1858201 atagattaat gtcatatttg tgcttcatca tatgaaaaac agactctctc gccttccatt 1858261 tatcgggctg cggccagaga tcagtgcttt tctgaataat ttcacatctc agtttatgga 1858321 aatcagtctc ggatttttct tcctttttct tgaaataata tgaagtgcag taggcaaaag 1858381 cggttgccag catccaaaat aaataaaagg tatggctaag tatttcttga agtataagct 1858441 gaggctccgg gcttttgatc atgatcataa cacataataa gcctaggcag ataagtgaag 1858501 cccatcgcca tctgcggcat tgtgctgcat aattttcgaa tttttgtttt cgttttacca 1858561 gcgcttggag catctgtttg gtcggcgcgt ctgtaaactg atccagctga ttccataagg 1858621 attccatacg cttcacacct tgtccatttt cattgctaca atatatgaac gtaaaataaa 1858681 aataataccc tattcatcca ttaaagggat gtccaaaact tgtccggtgt aaacatcatt 1858741 tccattcaga tgattatatg ctcgaatttt ttcttctcct gtccggcttt tataatactt 1858801 catggaaatg cggtatagcg tttctttctt ttggacggtg tgcttgacaa cgcgattcgg 1858861 cacattttga actggctcag ctggctgttc ttgctgttgt actgttgatt gggaagagga 1858921 agcagccgcg gcggttgctt cctccttatt tggcgagtct tctttttccg ctacagcagt 1858981 ctgtttctta tcagcagctg tttgctcttt tggcttggaa tcttctggct ctttttttga 1859041 ctccttctgc agtgcggttt ctttagtgtc tgcggtatcg tttttatcct ctgatttcgg 1859101 gacaacctca tatttgcttt ggctgctgtc aataaaaaca tcttcataat cgtcatgatt 1859161 atccgggtgg ctctttagat aaaataaggt gactaaaacg ataaccggca caaatacaaa 1859221 tattactgcg agtactgtga ataatggcgt ttttgttttg ccttgctttt ttttctgttc 1859281 tctttgattt tttacagatt gtcttgtcgg aaggctttct ccatcatcga cataatcgtc 1859341 cgccaatgcg gcgttttgat cttcataaag attctgggct tttcttctct ctactctcga 1859401 catgttcgtc atgtttatcc ctcctcacat gttcaaaacg aatctgacag gcaaacacgg 1859461 catcaatgat aaaatgcgcc gtcatcggaa caaataagtt gccggtccat tcatacatca 1859521 gaccgagcaa aaagctgatt gctgtcacca taataaataa cagccatttt gacaaatacc 1859581 gaaagtgcag agcggcaaat ataaggctgg ccgtccataa accgatatga gtctgcagca 1859641 ctcctctgaa taacatttct tccgcgaaag caatcagaag cgttaaaaat ataatatgag 1859701 ggattgacct cttactgaat atttttttat tgattccgcc gtcatcatat aaatgagacg 1859761 gaaaccattt cattactgcc atatcggcta aaataacaat aacagctata gaaacaccat 1859821 accagatgat tcgcatatcg cgaatgtccc agagctttaa tacgtcccgt acatcctcaa 1859881 aaaagaacag tcctgctgca gcagcggcaa agatgatgag tagctgcgtc aaatataact 1859941 gcttcagcat atcatggtca gtcatatgct gaatataatc tttttgctgt ttcagttcag 1860001 ctcacctaca gtctgcaagc tgaatatccg gtgcaattcc gaactccagc tgtctaatgg 1860061 cgccatttta ctccgttccc ctttttgttc atacaaggat aaatcaaaac cgcaatgtga 1860121 acagcacggg aggtttccgt catcaggctc gtatgattca tcaaagtagg ttaacagtgc 1860181 ctgccttaaa cagccgtcac gctgaagcaa aaatgataca cggtgcattt tttccagctt 1860241 cagctccatg cgatatgaaa tttctttctt catcagttca actgatgttt ttccctgcat 1860301 aaagagatga atcatcatac gggcctgtgt ctctccgacg ccatactgaa gtaatacgtc 1860361 acgcagcctt ctctcatccc gctcctccgt cttctctagc acacggatta cgtcggcgat 1860421 ttcttcagct gtgacactct ccatctggat aatttgttcc tgcaattcaa aatcccctgg 1860481 cgcccgcagc aaaatgctga cactcggctt tccgtcgcgt cccgctctgc cgatttcctg 1860541 cataaaagct tctgccgtct gcgggagatg aaaatgaatc acatatctga tatcaggttt 1860601 atcgacaccc attccaaacg cattcgtaca acatatcaca tcaagctggt tatgaataaa 1860661 ctgctgctga attaaaatcc tgtcccctga ctccaaaccg ccatggtaaa agtcggctct 1860721 gctgctcgtt ttgcttttaa tttcacccgc taattcctta gcccatttcc gtgttggaca 1860781 ataaacaatt cccggacctt gcaggttttc aaccagctga atgaccctat ctattttttc 1860841 ggcagtatcc gccgcatttt caaccctcag tgcgatgttt gggcggttga ctgagttgag 1860901 atggcgtaca gcatgctgca gctccagcag gttcatgaca tcttgcagcg tttcctttgt 1860961 agccgtggcg gtcaatgcca gaacgggtgg gtgtccaagt ttttttctca gctgtccgag 1861021 ctttgaataa tcaggcctga agtcgtgtcc ccattcagaa atacaatgcg cttcgtcaat 1861081 aacaaatagg ctaatcggaa cgcttttcaa tttttccaat acatatggag actgtaaagc 1861141 ttcaggagac aagtacaaaa atttatatcg atgaatatgt tctaaaacaa attgtctttc 1861201 ctgcctgtta agcatgctgt tcaaagctgc agcacgcttt tccccccggg ctttgagctg 1861261 ctgcacctga tcctccatta aagaaagcag tggagaaacg attaatacca tgccatcaag 1861321 catataacca ggcagctggt agcaaagcga tttccctccc ccagtcggga gcattgcaat 1861381 ggtatccttc ccgctgagta tgctttcaat aatgtcctgc tgcccttttt taaaggaagt 1861441 aaaaccaaaa aactgatata acgtttgctg taatttagtc atattgctgc acctgctttg 1861501 tcaatgccag tctgatttga aagtagctga accgctgttc cagcccgtcg cgaatttgtt 1861561 tgattttatt cgtccgcatc cgtttggcaa actctgcgat ttgaagctgg tcttctgctg 1861621 atacatagtc attaatcata aacgcaggct catggagaga aatctcgaca atgtggtctt 1861681 caatcgtcgc tgttttcagc tttctgattt cagcaattcg ctgtatcgga aacccttgtt 1861741 tgaccatctg ccatgttttc ctcgtcgact ctgtcagggc attatctaag tgcacatcag 1861801 aaaggagatc ctttaacaaa gcatcttcac actccggaag agaatgaata aaataatgta 1861861 ccgaagccca aaacatgata tagacatacc attcgtcttc tttcagcgta tcagcaagct 1861921 gcctgctcgt ataaccgatc cgatggtgcg aggttaagga gtagacaaaa atttgcgctg 1861981 ctttgttttc aatctttttc aaatgcgcct caagcatggc aaaaaggctt tttgccatct 1862041 ctatatgatc cgtatgccgg gacaggtatt tctttaccca gtgaagtgtc ttatgatcct 1862101 ttgtgacagg gatatactgc ctgctccctt gctgtttatg ggataggacc tgcacaagca 1862161 gcgaaagcct tttccaaagc acgccggcag cctgctgata atgagcgccg tgacaatgaa 1862221 cgggccaagg ccgctcgcta agggcatgtc tcaaaactgc tgcgccgctg gctgtcactt 1862281 tgtatgtatc tgattcagac attggcgcga gatatgaatg cttttcaagc ttgtcaagcg 1862341 acgcagaaat atcgcttctc gaacattttg ccgccattcc aaagtatttt gcagtctgaa 1862401 ataagccggc atcttgaatg gtctgtgacg atctcttgcc tttgaatagg tgaaaaacag 1862461 cgcttcccga ccgttccccg tttattttgc aaagacaatc gagaaccata atatcgaagt 1862521 aatttaatga caacctatcc acctacattc ttcctgacaa aaatcgttga tttgctcttt 1862581 ttattttaac agatttcaaa cagaaatcga cgtttaaagt catcattaag ggggatgtta 1862641 tgtagataac cccttatgtg ataagcattc tcaatcattt ttctgttgaa atgtggcagc 1862701 aacatcatta caataagtaa gaggaatagg tgttaaattg attaaatata aagattgatc 1862761 catttgttcc accaagaaca atctgggagg ttttattcat ggcaaagtac acaatcgtag 1862821 acaaagatac atgtattgca tgcggcgctt gcggagctgc tgcaccagac atttacgatt 1862881 acgatgatga aggcatcgcg ttcgtaacgc ttgatgaaaa caaaggtgtt gtcgaagttc 1862941 ctgaggtact ggaagaagat atgattgacg catttgaagg atgccctact gattccatca 1863001 aagtggcgga tgagccattt gaaggcgacc cgcttaaatt tgaatagaag taactaaaaa 1863061 aagctcccga acgggagctt ttttatttaa tggatatgtg cacttcgctg ctgctcaatc 1863121 catggcttaa gcttgataaa aattagtgag aatacaaccg taattacaat accttttatc 1863181 atgttaaacg gcaggatacc tgcgacgact gctgttttta gcgcgctgtc ggataatgcc 1863241 ggtgaatgta aaaaccacgt gtatgccgga agaatcagaa cataatttaa aatactcatt 1863301 aaaatggtca tcgctgcagt tcccaaaagc aggctgacag ccaagccctt tgctgagttg 1863361 agttttttaa ataagaaagc agtcggtaat ataaagagtg ttcctgcaat aaaattcgca 1863421 acttgcccta caggaactcc ggccatgctt ccctgaatga tatactgaag aacatttttt 1863481 atcgcttcta cggcaatacc cgccaaaggt ccgtaaatca gaatggcaat aattgcggga 1863541 acgtcgctaa aatcgatttt taaataatcc ggaagacccg gaaacgggaa atttaacagc 1863601 atcaaaacaa atgcaatgct gctcagcatg ctgaccacaa ctaatttttt tactttcact 1863661 tcattctctc cttttcgatc acatcttact cgaaaacgga aaggttcttt tccagccaat 1863721 aaaaaaaccg cttcatatat aaaagcgggg tttcgaaaat taggctaggc aaagaaacgt 1863781 ttgaaaaatt caatttcaaa acgcttatga acctccatct tctcccatcc agactgtact 1863841 gtcggctccg gaatctcacc gaatcctgct gtaaagacag ctcgcgggct tagagccatt 1863901 ggctcatcac cgccggtagg gaatttcacc ctgccccgaa gattgatcat atgaaattta 1863961 attacattat aaacgataac tggttggctg tatagagaat tgcttcaaat taaatatatt 1864021 acctgcaagc tgtcagatca ttgatttatt aggctttact tttatccttt actgcgtcaa 1864081 tacacgttga cactcttttg agaatatgtt aaattatcag atatttagtt tgtcaattta 1864141 ggaggaaatc taacgatgtt tcgagtattg gtctcagaca aaatgagcaa cgacggttta 1864201 cagccactta ttgaatcaga ctttattgaa atcgttcaaa aaaacgtagc agatgcagaa 1864261 gatgaattac atacttttga tgctcttttg gtgcgaagcg cgacaaaagt aacagaagac 1864321 cttttcaaca aaatgacttc tttaaaaatt gtcggaagag ccggtgtcgg tgtcgataat 1864381 atcgatattg atgaggctac gaaacacggg gtaatcgtga tcaatgctcc gaacggcaac 1864441 accatttcga cagctgagca tacatttgca atgatctctt ctttaatgag acacattccg 1864501 caggctaata tctcagtgaa atccagagag tggaaccgca cagcttatgt cggttcagag 1864561 ctttatggaa aaacgcttgg tattgtagga ttaggccgaa tcggaagtga aattgcacag 1864621 cgtgcgagag cgttcggtat gactgtgcac gtttttgatc ctttcttaac ggaagaaaga 1864681 gcgaaaaaaa tcggcgtaaa cagccgtaca tttgaagaag tgcttgaaag tgcggatatc 1864741 attaccgttc acacgccttt aacaaaagaa acaaaaggct tattgaataa agaaacgatt 1864801 gcaaaaacga aaaaaggcgt tcgcttaatt aactgtgcgc gaggcggaat tatcgatgaa 1864861 gcagcacttc tcgaagcttt ggaaaacggg catgttgcgg gagcagcgct tgacgttttc 1864921 gaagtcgaac cgccagttga caacaaactt gttgatcatc cattagtcat tgccactcct 1864981 cacttgggag catcaacgaa agaagcacag ctcaatgtcg ccgcccaagt gtcagaagaa 1865041 gttctgcagt tcgcaaaagg cctgcctgtc atgtcagcta tcaacctgcc tgccatgaca 1865101 aaagatgaat ttgctaaaat taagccttac catcaaattg caggaaaaat tggcagcctt 1865161 gtatcacagt gcatgaaaga accagtacag gatgttgcca ttcaatatga aggcacaatt 1865221 gctaaacttg aaacatcgtt cattacaaaa gcccttctgt caggcttttt aaaaccgcgc 1865281 gtagactcta ctgttaatga ggtcaatgcc gggggtgtcg caaaagaacg cggcattagc 1865341 ttcagtgaaa aaatttcctc ttctgaatct ggatacgata actgcatcag cgtaaaagtg 1865401 acaggagacc gcagcacctt tactgtaacg gctacgtata ttcctcattt cggagaacga 1865461 attgtcgaga tcaatggatt taatattgat ttttatccga ctggtcactt ggtgtatatc 1865521 cagcatcaag atacaacagg tgtcatcggc cgagtaggac gtattctcgg agataatgat 1865581 attaacattg caactatgca ggttggccgt aaggaaaaag gcggagaagc catcatgatg 1865641 ctttcctttg acagacatct ggaagataaa attgtgaaag aactaacaaa tgtccctgat 1865701 attgtgtctg tgaagctcat tgatctgcca taattaaaaa aactcaagct atatagcttg 1865761 agttttttta ttgttctatc cccgtgtgtt tttatgcaaa atatctaaga cactccttag 1865821 ctcagaaaca ggaatttggc ctggtgcgga cgcctcttct ccagctccaa aagtacaagc 1865881 cgatccaaaa acctcaccgc tcagcctgct gatgagccct gttgcagcca ttgacattgt 1865941 aataatgggg cggtctgcat atattgtttt cattgtatac gtcgcatcaa gcagtgttag 1866001 gagatctcca gtatcattcg gcatgacagc catttttgga atatgcgcgc ctaagtcctg 1866061 catttttcga agtctggaaa taatttcatc ttttacaggt gttttttcaa agtcgtgatt 1866121 tgacatcacc acatagacgt tgttttcttc cgccagcgat actaacgctt ttacatttgc 1866181 atctcctgaa aataattcga tgtctatcag atcgatgtct tttgtttgga ttgccgattc 1866241 cagcaaagca agataggagc tttcgtccat ctccatgctc ccgccctctt tgtgggttct 1866301 gaatgtaaat agaaatagct tgtcttctaa agatttacga agcttagaaa tgagctttgt 1866361 gaccgcttct ctgtcattcg ctttttcaaa tacgtcgact ctccattcaa caatgtccgg 1866421 attcagtaat tttactgcct ctgcttcatt cagaatttgt ttttccgtct ttcccatcag 1866481 cggaatgatg attttcggca tcccttcccc gatggaaact cctttaatcg ttaacacgtt 1866541 cactcgtctc aaatcctttc aatctttacc ttgttttatt atacacgtac aacttttttt 1866601 tgaaaatttc tattatatga atagcaacta aaaaagagcc ttaaagggct ctttttagtt 1866661 taaggaaatc ggatttggag cagctggcac cggaattgca tctgatatgt catatttgcc 1866721 gatttttttc gttctggttt ccgtaaaggt cacttctgtg aagccaaact cttttgcagt 1866781 caaaagtagt ccctcaatca ttaaaatacc ggcaatagaa tcatcaactt ctgactcctt 1866841 tgaaaagcgg atatataagt gtttctgttt cttcgttaca gattggacag cacccgcttg 1866901 aataagaggt gtcgtatctt cttggctgct cgattccatt tccttaatcg cttcttttac 1866961 tgtatcaaaa gaatgatttg acggaacgag aaagtcttgt ccttgtttat tttggtacaa 1867021 gtagtaggat cgttttgact gtttgggaat cgaaatttcc gtaaaagtgc catatgagcc 1867081 aatccgaacc ccagtctcat tttgatccga taaaaatttg actttttcat aaggactcca 1867141 ttttaaggat tctttaagca atttttttaa cagtgtatca tcttttatag aaaatgccgt 1867201 agctggctga tggactcgta tacttaattc cttctgcttt ggtttttcct ttatttctac 1867261 ttcatctatg aaggttggaa ttgtaatggc atgatcaagg atgcccaatt cactactttc 1867321 aaacagcata tcctggatcg tttggtctgc atttgttttt tgaatgctga cgggtatgat 1867381 tgcagatgta tcggcatcag caaccgctac agtgatgtaa ttgtcttgtt ccttttcagg 1867441 aacgacaaac gatgtctgat ccaaggacga tgcagctttt gggctgtctt ctgtctcagt 1867501 tttcgttact gcgttctctt gggacgcttc tttttgttga ggctgtgcct gatcaaagaa 1867561 atgaggagaa ataatgaagg cgatataaac cgcaattgca gcggcacacg cggggccaat 1867621 ccacctgaca gcgggcttat ttttacgctt tgccatcgtc agccgcttgt aaatatcctg 1867681 aggcgaacga tggtctttaa ctgccggaag ttgacttaac aactccttta tctgttcttc 1867741 gttccattct gacttcatca tccattagct cctccctcaa aagctccata tgtttccgaa 1867801 gtactttgag ccctctgtgt tgggtcgttt ttactttgct ttccgagaag cgcagagcct 1867861 tggctgtttc ctgtattgaa tatccctgaa taaaccgcaa gataatcaca gctctttgat 1867921 cgattgtaca ttgatcaagc gcagcataaa tttcccggac attttcatgt tgaaccgcaa 1867981 gttcgtccgg cagcaattgc tgatccctga catcctgtgt atcccagtca aatgtaccga 1868041 gtatacgctg tctgattgtt tgctgtttac ggaaccagtc tatcgcaaca tggcgtgcga 1868101 tagacaaaag ccatgttttt tcactgcttc ttccttcaaa cgtatgataa gaatttaata 1868161 cccggatata aacctcttga agaaggtctt ctgtctggtt tttatccttt accatataaa 1868221 ataaaaattg gtacaaatct tgatgatatg tatcatataa taattgaaag gtttcttcca 1868281 tttgaaaccc ctccgttcac ttttttgtcg tatgaatagc ttgaaaagtt acattacaac 1868341 tatattacga gtaactggaa tttggaaggg aatttatatt aacatatcct taaattttat 1868401 taatgttggc tattaaaaaa acacccgctc agtcagcggg tgtttcttat ggaacaagat 1868461 tcttcggcaa attcagactc gattttaccg ttttgtcgga atataaaaag aaaatgttgt 1868521 tcctttatct attcggctgt gcacagtaat tgatccgttg tgggcttcca cgatattttt 1868581 aacgatagcc agccctaacc cggttcctgc tctgcccctt gtccgcgctt tatctgcctt 1868641 ataaaaccgc tcaaagataa atggcagatc ttcttccggt atgccagacc cggagtcttt 1868701 gatatcaatt ttcaatccat ccttcacaga atggactgaa atggagacac tgccgccggc 1868761 tgaagtatgc cgcagcgcgt tatcaatcaa attggtaaat acctgctcca tcttgtcttc 1868821 atcaaacata aattcctctt ctgtgagaga aatgtcatga tctaaagcaa tatttttttc 1868881 tttcgcaaca ccggaaaact tccgaatgat cttttctaaa aactcattca cattgatttt 1868941 ttcataatgt aagcctgtat ggcctgattc cattcgggct aaatcaagca aatcattaac 1869001 taaacggccc attcggagcg attcgtcata aatgatttgg gcaatttctt tccggtcttc 1869061 ttcagagctt gcaatgtcat cgacaattgc ttcactgtat ccctgaagca tggagatcgg 1869121 tgttctcagc tcatgactga catttgcgat aaagtcctcc cgcagcttat caaggcggcg 1869181 ttcttctgtc atgtcacgca gtacggcaac cgctcctctg acgtgcgatt ccgcataaag 1869241 cggcgacatc aaaagcaccc atgatctgcc ttgaagcgtc atctcaatca tttgttcttt 1869301 ttcagtgctg acagcgtttt gaaacagctc ttttgcttca ggcggaagat tgtcgccttc 1869361 tttgatattc atgttctgtt cataatacca agcctgaaga aaacgttcag ccggcgggtt 1869421 ggtcacaaga atcgtaccgt caatattaat ggtaataacc ccgtcagcca tactgctcaa 1869481 aatgttagaa agctgctctt tttcttgatt gagcgcattg atatgaaagt taagctgccg 1869541 gcccatttga ttaaaagcgg tcgccagttc accgatttca tcctgagtta aaatcgggat 1869601 ttttgtatcg aacttgccct tcgccaaatc ctgcgcgcct tctctcattt ttcggagagg 1869661 gtacgtgacc ctgcttgata aaaagaatgc gaaaaatgtg gtcagcacaa tcgcaattcc 1869721 agcggcaaga aaaatatagc gggtcgtatg ttttgttgta tctttaacgg caagcaaaga 1869781 ctgggataaa aagaccatgc ctttctttcc gtctttttca tacgggacac ctacaatcag 1869841 gcgttcatta tccgtgtctg tatcgctcag tcccgtccgt ttgcttactt ttttatggtc 1869901 tttgagagct ttatttaagt ctttgtcatg ctgtatttgc tcaaccgtaa tagacgacag 1869961 gcgattttta tcattcggag aataccagtg gttcttctca tcctggatga tggcaatgct 1870021 tgttaagtta tcagcgagtt cccaagtgat tgaccttgcc agtgcctggt cctcgtgatt 1870081 ttctaggatg acagcaactt tattcgcaag ctgtgttaaa tcattctcag cttcttccac 1870141 atggtagttt tcaataaact ccagcaaaag aaccgttaaa atgaacaata cgatcaagac 1870201 gagtgaaagg atcgtaaacc acagcttgcc tactacgctt ttccaaaatt tcattcagcg 1870261 ccgacctcaa atttataacc tacaccccat acggtgacaa tttttttcgc agcttccgga 1870321 gataccttgt tcagcttctc tctcaagcgt ttgacgtgag tgtccactgt ccgtaaatca 1870381 ccaaaaaact catattgcca cacttctttc agaagctttt cccgatcata caccttgtca 1870441 ggcgttttcg ctaagaaata tagaagctca tactcttttg gcgtcaggct cacttctgtt 1870501 ccatcagctg ttacgcggtg agcatcatgg tctattgaca gatgtgaaaa cacgagcaca 1870561 tttttcgtcg gtgtattggc attgaaataa gaggtttggg atgctcttct caaaagggcc 1870621 tttacacgca gcacgacttc tctcgggctg aacggcttaa caatataatc atctgttccc 1870681 gcttcaaacc cctgcacccg gtttgcttct tctccttttg cggtcagcat aataatgggt 1870741 gtcgcttttt tttcacgaat ttgccggcac acttcaattc catcagtccc cggcatcatc 1870801 agatcaagca aaattaagtc ataattggct tcaagccctt tggcaatggc ttcatcacca 1870861 ttttcagctt catctatagc ataattttca cgttcaagat acattcttaa aaggcggcga 1870921 attctggctt cgtcatcaac tactaatatt tttgtttcgt tcgtttggtc catgttttcc 1870981 ccctgctttc cttctgttac tttcatttta tcaaatcgtg agaaagtttg agaactgtgt 1871041 cgctttcaaa ggactatgca taagaatgaa gtccggcaag cacaagattt acgaatatta 1871101 aattaaacat aataatagca aaaccgatta cggccagcca tgctgacttc tcaccgtgcc 1871161 agcctcttga cagtcttaaa tgcaagtaag cggcatagaa caaaaatgtg atcagcgccc 1871221 atacttcctt agggtcccag ccccaaaatc tggtccacgc gagctgagcc caaatcattg 1871281 caaagatcag cgcgccgagt gtaaagatcg gaaatccgat tgatacggcc ctgtacccaa 1871341 cctcatccac cagatcaaga ttgacgtttt tcaccagcgg atgtaataga gcgctgattc 1871401 tttttctgat gatcagacgg agagccccat acaacacaag acctgctcca aatgaccaaa 1871461 tgacagtgtt cacttttctg cctgagaaaa gcgcgggaag atcaacaagc ggttccattc 1871521 ttccttcggt caaaagctct ccctgatgcg gaccgacaag cgcgggcatt tcgtacacca 1871581 tcacgctttt ttctttactt ttgtccaccc agttaaactc cgcttcatag cctgcaagac 1871641 gaaatgccga tgtgattgca ataaaggcga cggttgtgac caggataaac ataatcgctt 1871701 caagccagaa ggtctttttg cttggctttg tctggtctac atgcttcaaa agaaagatga 1871761 caccagcgac aaagctgatg gcaagtatag cttgcccaag cgcggccgtt gttacgtgaa 1871821 tatacagcca gttactttgg agcgaaggaa ttaaaggcga gatatctgtc ggaaacatgc 1871881 tggcgtaggc aatcagcaat aaagcaattg acagcgtaaa caggcctaat gaaggcaatc 1871941 tatagagaaa ataaagaatg ataaacgcca aaacaagcat catgccaaaa gcggtggtga 1872001 attcaaacat attgctgaca ggcgcatggc cgcttgcagc ccaccttgtg atgaaatatc 1872061 ctaggtggca gaaaaaaccg acaatagaaa gggtgattcc aatgttggcc catcggtttg 1872121 gcctgccctt tttatcttta ttcccgcgta tggccccgcc gaagattggg acagcgatta 1872181 aatacacaag aaaggccgca taaagaaaat ttccgctcag ctctgccatg acatcactcc 1872241 cttttcgcct atttctgtgt tttgattaat tctttttggt ccaccggttc agtcagtccg 1872301 gaatcagcca atataaatgc taaatccttc ttcaggccaa accagttttt attggtatgc 1872361 cctgctacca taactgcacc gtcctgtgag tgcagccaaa ttcttcgatg ctgccagtac 1872421 ataccttgaa tgacaccgat cataaaaatg gctccgccga cagcaagcac ccagagtgtc 1872481 agatcctttc tgactgtaag tccagtaatg tttttcgttt cgacatggtc aaatttcagc 1872541 ttgtatttat tattgcctga tccttcgatg gtttcttgga tggcgacaaa gctcttttcg 1872601 cctttcggtt tgtccggcgt tatgatatta aagacaaaag ccggattgtt agggatcttt 1872661 gtttttgtgc tcggctctcc gtcctgatta aaatagaagt caggcaggta gctggcgatt 1872721 tccaccttgt aaccgttacc aagatcatag actgaatctg gatccagaag gttgatcttc 1872781 aggctcccaa aggatttttt tgttttttta tcaatcagct ggaacaccat ttggtcaagc 1872841 tgattctctt tgtaatccac ctggtaaacg gaaaaagaat caaaacgcag cggctgattg 1872901 acacggatgt cttcttctgt tactttttcc agcttcggct tctcgccata aacaattttt 1872961 ccttctctct tgtagagtac ggcatcagtt tgaaagttct ttgccactct accgtccccg 1873021 actctgtcaa tggcatctgc aaataccttt ttttccgttt tgctgttata ggtctctacg 1873081 ctgaattgat tgtttttcaa ataatatttt ccgtctgtac ccggaattgc tgcggtttcg 1873141 ccttctctga cccaaagcgt ctcatcgacg tacatgccag gcacaaatct cagcatcgca 1873201 ccaatcagaa agatgatcaa tccaatgtgg ttgacatacg ggccccagcg ggaaaagcgt 1873261 cctttttcag caagaatgct gccctctttt tctctgattc tataatgttt tttctttaat 1873321 agagtaacta tcttttcttt cgattccccg ttcagtacag taactgtttc actgaacaag 1873381 cgctgccttc ttaaaaaggc cgggctcctt ctgacacctt ggttttttaa cgctctatac 1873441 aacggaatga cccgatcaag gctgcaaatc acgagtgaaa tgccgatcga ggcaatgagc 1873501 agcaaatacc accaagaacc atataaatga tgaaacccga gcaaataata aagctggcca 1873561 aacgtgccgt actgctcctt gtaataagta tcagcctgtg cgcccggagg cagataggct 1873621 tcctggggaa aaatggtgcc gaacgctgat gcggcaaggg ttatgacgat aagccatatt 1873681 cccaccttaa ccgaggaaaa gaaattccaa attttgtcga tgatcgtttt gttataggtt 1873741 tgcgaacgtc ttgcgcttcc gtcatatctc atatcagcga gcggaggttg agtttcctga 1873801 agagctcttc cgcacgattc gcataaaacg gttccgaccg ggtttatatg tccgcattca 1873861 catttgactt gcttcatccc gaagtctctc cgggttttat gagattcata taatcgtgta 1873921 tcatgctttc tgtcatagtg ccggtcacca ccttgacaac ttttccttcc ggattgatca 1873981 aaaaggttgt cggaagcgga gatacgtcat aggcatcaag cacttggcga tctgtatcca 1874041 gaacaaccgg gaaattgact ccgtaggatt tcataaaatt atgtactgct atctttgact 1874101 ccccaacatt tacagcgaca atttcaacac cttggctttt aaaatgctta tattggtttg 1874161 ccatataagg aaactctttt ttgcacggtt cacaccatgt accccagaaa ttcaaaaaaa 1874221 cacctttccc ttttaagtca ctgagctcga tacgtttccc attcgtatcc tctaggacaa 1874281 aattcggtgc gtcggaccct tcggatatac tctctttgcc ggcaaataca gcgttgtaaa 1874341 tggtatagcc gagtgcgcag attaaaacga gaaggatgcc ggtccgaatg aataaacgcc 1874401 tttttttctt cattgtccac tgcccccttc cccctattgc agatccattc aattatatca 1874461 ttgcacgttc atttcacatt tcttactttt tgaaggttat gtgaaattta gaaagcgttt 1874521 ttaccgtgat ccgccagtgc tctgagcctt tttacttcgt gaggcgtaag ctctctggca 1874581 tcgcccgtgt gcaggcctcg caggtttaaa aacgcgtatt cctcacgctt cagcttgatt 1874641 acctcatgtc cgatcgcttc aaacatgcgg cgcacttgtc tgttgcgtcc ctcatggatc 1874701 gtcagctgaa taatgcttgt ctgctttttc ttatccaaag acagcagctt cgctttagca 1874761 ggcgctgttt tgccttcctc cagcctaatt ccgcgctcca gctttctgag cagctcttta 1874821 ggcgggattc ctttcacctt cgccacgtat gttttgtcta tttcatactt aggatgcatt 1874881 agcttattgg cgaattcgcc gtcattggtt aaaagcaaaa gaccgctcgt atcatagtcc 1874941 agacgcccaa tcggataaat gcgctgcgga atatttttaa aaaagtccgt caccactttg 1875001 cgtcctttat catcttgcgc tgcggaaata acgcctcttg gtttatataa gagaaagtaa 1875061 accggctctt cgcgttcaac ctttaacccg tttacctcaa tctgatcaga accggtgacc 1875121 ttaacaccta gctctgttac tactttgcca ttcaccttta cttttccttc tttaatcagc 1875181 tcttctgcct ttctgcgcga cgcaactccg gcatgagcaa tcactttttg cagtctttcc 1875241 atgtctttca cctcaagtat tatcttactt ttttcaacct taacaaacaa gctttttcaa 1875301 attcctatgc caaatctaaa aaaaacgccg ttttcaggcg ctcccaaata ataacgtaac 1875361 gatgatgata gatgcaacta cgccgattaa atctgcaaga agtcccacct ttaatgcatc 1875421 acccattttt ttaatgccga ctgctccgaa atacacagtc agtacgtaaa gcgttgtatc 1875481 tgtagatccc tgcatgacgg aagccagcct gccgataaag gaatcgggcc cgtatactgc 1875541 aattaaatcg gtcgtcattc caagtgcggc cgtaccggag atcgggcgga tcagagcaag 1875601 cggcactact tcagcaggga tgccgatagc ggagaaagcc ggttttaaaa gatccattat 1875661 aaaatcaagc gcgcctgatg atctgaaaac agttatagcg acaagcattc cgactaaata 1875721 ggggataatg gaaaaggcaa tttctatccc ctctttcccg ccttcgacaa acgattcata 1875781 tgtcggaacc tttttgatcg ttccataaag aagaattccg gcaataatga ttggaatcat 1875841 ggctaaagac agccagttga tgatttccat ccgctcacct tcccttcttt ttgcggcggt 1875901 aataaaaata ccgatcaatg ataatggcac cgattccgga aataagcgtt gccaaaatgc 1875961 ttggcccgac gatatctgtc ggcgttttgg aggaataagc cattcggaca gcgatcaccg 1876021 ttgtcgggat gagtgtgatg caggacgtat taacagctaa aaaagtaatc atcgaccggc 1876081 ttgcttccga tcggtttccg ttcagctttt tcatttgttc cattgcttta atgccaagcg 1876141 gagttgctgc atttccgagg ccgaagaaat tcgccataag attagataaa atatagccca 1876201 tcgccgggtg atccggcggt atatcaggga acagtttaga tataaaaggt ctgcacatcc 1876261 ggctgaaaat atccaaaagc cctgactgct cggcgatttt cattaagcca agccagaaaa 1876321 caagcacgct catcaatcca aatgagatcg taatcgcttc tttcgcaccc ttaaacacgg 1876381 cttcatttac atcttgcaga gttccgttgc acatcgcaaa aacgagtccg atcacggtta 1876441 aactgaccca aattatattg accattttgc tccgcctgcc gcattcagaa agattgattt 1876501 aaacgtttca aaaaattgtt tcttcggttt ttgatgccgc tcattttcat aatagatcgg 1876561 cacttttgcg atggttgcat cgttgaacat gatctccatg tgccctacga tgtcagggat 1876621 tttcgaggca tctttttccc atgctttttt cggcttgagc agtgtggtat taatttttac 1876681 attttctttt tcctcttcgg tcagcaaata ggtgatatca cgtttgataa aagccttcga 1876741 ttcataaaat gtgcctttca gctttggaat atcccctttt tttgcaatta aataggtttg 1876801 ataatgctca aacacatagt taaacatctt catatggtca tcccaatcat tagggtcatt 1876861 aatggtgacg gctatcaggt caatgccgtc ctttgaagcc gtagagacca gtgtccgttt 1876921 tgcaagtttt gtatagcctg tttttcctcc tgtgctgtac ggataaagca tggtcagcag 1876981 tttgtttttg tttttccata cgctttccat cgtttccgct ttgtatattt ttgtgcctga 1877041 aatcttttga tagtctttca gcttcatagc atacttagtt aaaatggcca tgtcataggc 1877101 tgttgaataa tgattttcat ggtcgtccaa tccgtgcggg ttttgaaaac gggtgttttt 1877161 cataccaagc tgctcggctt tttgattcat catataaaca aacccatcga ggctcccacc 1877221 gacatgctca gcaatcgcga cagcggcatc gtttcctgat cttagcatca ggccatacac 1877281 aagatctttc agcttcactt tttgaccttc tgttaaataa atggcggagc cttctgttct 1877341 gacagcattt gccgaaaccg tcactgtttg atccattttg ccggattcga tggcgaggac 1877401 ggcggtcata atttttgtga tgctcgcgat ccgccttttt tgatgctcat ccttggcata 1877461 taacactctg cctgacgcac cgtcaataat gatcgcgctt tttgcactga catctatagc 1877521 agcatgtgct gtattcacat ttacggttgc aataagaaaa gaaatcatga tcacgaatac 1877581 tgcttttttg aaaatgcgca tgtttgctca cgtccttgtg gtggtttgta caagtttatg 1877641 cgcatgtcca tcagttatga ataacaatta tatttctgga agcaaacata aaaaaactct 1877701 ccctgaaaaa gggagagtaa acgttatctg attggcgcca tgcttgatcc ggacgcttcg 1877761 taatgagcca gctcttccct catcttcaga aaggccgcgc tcaacggcaa taataattgc 1877821 tcaagcgacg caggaacagc atgataaaac tcaattgcgc tgaccccggt ataagacgcc 1877881 cggctatttt cacaccacgt gtcttttttc ggcataaaga actcttcaat gcattggtga 1877941 tacacattat aaagtgtttt ttccgctctg gcttcctgaa aaggctcctg catcaggaga 1878001 cgacggcacg cttctgcgcc tccttcacaa aatactgcca ttcttctcag agtgctaagc 1878061 acatcacagc agtatccttt ttcaataggc aattcagcct gtaaggactc aagcgtcgtt 1878121 tgatttaggt aatcgttcac ggtattgaca accattgata agaattcgcc tgttttttga 1878181 gtctgcgctc gcacaatcga atgtcccatt tcgtttggta tcttcccctc atgtatttgt 1878241 ctctcacatt ttgcttcttt catgatagct tcttccttat atcttatgat gatgaaaaag 1878301 cgcgattcat taaacttcta ttttatatct tcgaaggttt ggttaaagtt ttcaaaaaat 1878361 aaatctgctt cttcttgaag aacgtcttct tccgcatttt caggcagcgg cggaagctcg 1878421 tccagcgttt tcagaccgaa ttgttcaaga aaagtcggcg tagtaccgta taaaatggcc 1878481 cgccccggac catcggcacg ccctacttca cacaatagcg ccttcgcgac aagactgtgt 1878541 aaaatccgct ctgattttac tcctctgatt tcttcaattt ctgctctcgt aattggctgt 1878601 ttgtatgaaa caatggccag tacttctaaa gatgcttgag aaaggccctt tgacggcact 1878661 tcaatcagtt ttttcaagta aggcgcaaag tcttttttgg tagagagcat gtacgtatct 1878721 gcatactcaa taagttcaat ccctcgtgta tctccgcggt attcgtccgc cacatccgcc 1878781 atgatcgtgt tcagttcagg ctcttcgatt tcaagcactg ttaacagctg cttttttgta 1878841 agcccttcat cgcctgccgc ataaagaagg gcttccacaa tagctttcca attcacgata 1878901 tcaagcccca tgaatggatt cactccccgt aatgtaaata tctgaaaaat tgtgctcctg 1878961 ttcaatgagg accagctgat ttttcatcag ctcaagaaca gctagaaagg tcactactaa 1879021 atgttctttt tgctcatatg gaaacagatc cataaagtta attctcgttc ctctagattt 1879081 caagctgtgc acgatttcgt tcattctggc ttcgattggt atgtcctgtc ttgtaattgt 1879141 tgtttccatc ggcctgttta tttttttgcg tttcagcact ttttgaaaag ctccgatcat 1879201 atcatagacc gtgacagaga gcttttgctc agactgtttt acttcttttg catattcact 1879261 caaatcactc ggcggtttcg tgaacgattt ttgtctttct tcttcccgtt cttttaaatc 1879321 cttcgccgca tctttatatt ttcggtactc aatcagcttt tcaatcagtt cctcccgcgg 1879381 atcttcttct tcaagtaatt catcttcaaa aagctcctcc tcttgcttcg ggagcagcat 1879441 tctgctttta atgctgagca gcgtggcagc cataaccaaa tactcgctgg caatgtcgag 1879501 ctcaagcacg cgcatcgtat gtacatataa taaatattgt tcagtgatct tcgccacagg 1879561 tatatcatat atgtcaattt caagacgatt gattaaatga agcagcaggt ccaatgggcc 1879621 ctcaaacgta tcaattttca cttgatattc ttccatcatc tcaccatttt caagtatcac 1879681 tctcattgcc ggaaaaactg gctaccctat agtataagcc accaaaaagc tctcgtccaa 1879741 tactatttca tatcctgttt tgaaggagtt tgtacagaat attcaaaaca caagaggtgt 1879801 ttgctcggag cgcagaagcg ggagaaaaag cctttgcttc tggttttcct ttctaagaag 1879861 cactagaggc cgggcgttct tttttccttt tatcccttct atggtacact aaaagcacat 1879921 taaaggagga agcaccttgt atccgaaagc ttatatagat tatctcgttg agtttcatgc 1879981 gacacgggat tattttgaat gccatgaaat attagaagaa tattggaagg aagatccgcc 1880041 aaagaaacga aaacgctatt gggtgggctt tattcagctt gcagtggctt tatatcatca 1880101 cagaaggcag aatacagccg gggcaaaaag actgatggcg aacagcatcc ggattcttca 1880161 agcagaacac cgggcagtcg aagacttagg gcttgatcat ggccgtttgc tcgaacttat 1880221 gcaatcggtt tacgaacaaa tcgaaaccgt ctctgcctat aaaagcatta tactgccaat 1880281 caaagatgag aaactggagg aagcatgcag gatcgaatgc aggaaaaaaa agtatacatg 1880341 ggggcagccc agtgcactca gcaacatatt tcttatcgac aaacaccgtt tgcgggatcg 1880401 gactgacgtc atccgtgaac gtgaaaaaga aatagaacgc agaaaaaaaa gcagagactg 1880461 atcacagcct ctgcttaatt attgtatgaa atgtcttgat cctgctgacc ttgacaacgt 1880521 tcgaaaaagc tctgcgttaa ttcatttgga accagtactt gcgttttgaa taaatgcttt 1880581 aaagcatcca tcatctgttt tccgattcct tgatggcgat gagaaggatt cacactgata 1880641 tgccggatct caacctcaga atcctttttt tcgactccga ttgctccgac gatatcctcg 1880701 tcctctttcc aaagaaagag ctggcggtct gtatccgttt cgtagtcctt aattgtctgc 1880761 tgaagctgct taaggtcttt ttcattcggc ataaacgaaa gaagccccat cgcaatcttt 1880821 tcaaacgatt ttttataacg aattaacata aaaacccctc tatatccaaa atgtccagtc 1880881 tgctattaac ggatacgaat aggtgatccg ttttctcaca ttatatcatt ttcgccatat 1880941 ttttaaactg ttttcagcaa attattcaaa tgagcggttt aaatttgcca tttcaatggc 1881001 agaaacagca caatctacac ctttgttgcc cgcttttgtg ccggcacgct cgatagcctg 1881061 ttcgatgttt tcagttgtta caattccaaa gatgacaggt acaccagtag tgtttgctgc 1881121 ttgcgcgatg ccttttgcag cttcattgca gacataatcg taatgtgtcg ttgcgcctct 1881181 gatgacagtg cccaatgtga taatagcatc atattttttt gtttccgcca tttttttcgc 1881241 agcaaacggt atttcaaatg cgcctggaac ccaagccaca tcaatgtcat ttgtgtctac 1881301 gccatgtctg agcagcgcat cttctgctcc gctcagcagc ttgctcgtaa taaaatcatt 1881361 aaatcttcct actacgattc cgattttaag acctgtacca actaaatttc cttgtatgat 1881421 attcatatga ttcccatcct tttttgtgat atttgtgatt agaaatgaag taaatgacct 1881481 agcttgttca ttttggtttg caaatatttt ttattgtgtt ctttcgcctc catttgaagc 1881541 ggcactcttt ctgaaatact gagtccgtag ccttcaaggc ctgcgatttt tcgcggatta 1881601 ttcgtcaaaa gcttcatatt ccggacaccg aggtcgcgta aaatttgtgc tccgatgcca 1881661 tagttgcgaa gatccggcaa gaatccaagc gcctcattgg cttctacggt gtcatagcct 1881721 tgttcctgaa gcttataagc ttttaattta ttgattaaac cgatgcctcg tccttcttgg 1881781 cgcaagtaca ggagcactcc acggccttct gcggcaattt ggttcagcgc ggcgtgcagc 1881841 tgcggtccgc aatcacagcg atgagagcca aacacgtcac ctgtgagaca ttctgaatgc 1881901 acccggacca ataccggttc ttctccgaac ggcacatctc ccatcacaaa tgcgacatgc 1881961 tcttttccat ctacctcatt tgtgtatcca taaaccttaa atgtcccaaa atcagtaggc 1882021 agcgtaatgt caacttcacg ctcgacaagt gttgtcagat tgtaacggta ttgaatcaaa 1882081 tccttaatgg tgatcatttt taattgatgc tttttcgcaa tttcaatgag ctcaggcact 1882141 ctcgccatcg ttccgtcttc attcataatt tcacaaatga cgccggctcc tggagatccg 1882201 caagcttcag caagatcaac agcagcttct gtatggcccg ctcttttcag gacacctcct 1882261 tttttcgcaa tcagtggaaa aatgtgcccc ggacgctgaa aatcagatgg cacggatttg 1882321 ctgtccagca atgcttgaac ggtaaaagat ctttcttgag cgctgatacc tgtcttcgtt 1882381 tcacgatggt ctatgcttac ggtaaatgca gtgtggtgag agtctgtatt atgctcaacc 1882441 atagggtgaa gatcaagcct gtctgcgatt tcctcactga gcggcgtgca gatcagtcct 1882501 ctcccatgtg tcgccataaa gttaatgact tccggcgttg catgctcggc aagagccaca 1882561 aagtctcctt cattttctct gtcttcatca tctacaacga tgatgacttc gccttttttt 1882621 aaagcgtcca gtgcttcttc tatcggatga aacatgcaaa tcttcctctc taaaagccgt 1882681 tttcgcttaa gaaggctttt gtaatggttt gttgggtctt attttcattg gctttatgca 1882741 aaaatcgata catatatttt ccgatcatat cgcattcgat attcacttta gagccgatcg 1882801 ttttttctga aaagatcgtt tcgctgatcg tatgcggtat taaggagatc gtcactgtgt 1882861 cttctgtcag gccgaatatg gttaagctca cgccatccac agtaattgat ccctttaaaa 1882921 ccaatgtttt tgttaatgac gggtccattt ttaaatcata gtaaactgcg ttgcttttct 1882981 cttcaattcg tgtgatttcc gcagttccgt cgacatggcc tgagacgaaa tggcctccga 1883041 aacggccgtt tgccgccatc gctctttcca gatttacttt gcttcctttt gttaaatcat 1883101 tcagtgacgt agctttgact gtttcaggca taacatccac tgtgaattga ttttttgtaa 1883161 aatcagtgac agtcagacaa atgccgttca ctgcaatgct gtcgccaaga tgaacatcct 1883221 ctaaaatctt tgagcattta atagttaagg ccattgcatg ccctgctttt ttcatggatt 1883281 cgattgtgcc tgtttcttcg ataattcctg taaacatggt caccatccta ttcctttgtc 1883341 ggttttgccg tcagtttgat atcacggccg atttgggtta tatcagtgaa ttgtaataag 1883401 gggacatctt tcattgattg aaaaccttca ccggagatta agctgggagc atgcgttcct 1883461 ccgattagtt taggggcaaa atagaagatg atttcttgaa aacagccttc tttgacaaag 1883521 cttccgtgaa cagctgaacc gccttccaca tacaccgaca tgatgccttc ttccgctagg 1883581 atcttcaaaa catcaggaat ttgaatgcgc tcggtttcaa gtgtaaatat gttcactccg 1883641 aaagctgaaa gccgtttttt cttttcctcg tctgcgcgtg ccgtcgtaaa aatccatgtc 1883701 ggcgctattt gatcgcaaat cactttagcg tcctcaggaa tcgagagtac ggtatcaagt 1883761 atgacccgaa ccggctgttt tgttacattc ggcagtctgc aggttaagct cggattgtcg 1883821 gctttcactg tgccaactcc gactaaaatg ctttggtgtg ttttcctgta ttgctgagca 1883881 tcctgtcttg cagcctctga cgtgatccat ttgctgtcac ccgtgctggt agctatcttg 1883941 ccgtcaaggc tggcagccgc ttttagcgtg acgtacggaa ggcctgtcct cataaagtgc 1884001 agaaattttt cattcagcct ctccgcctgg tctgccagga tgccttccct tacctcaatg 1884061 ccagcttctt tcatcatgct gatccctctt ccagccacaa gcggattagg atctctcatc 1884121 gccacgaaca ctcttttgat accagagttg ataatcaatt ctgcacatgg cggtgttttt 1884181 ccgtaatggc tgcacggttc gagtgtaacg taaatgtcgg caccctctgc atgtgctcca 1884241 gccatatgga tggcatgaac ttctgcatga gcttcaccat attttaaatg ggcgcccatt 1884301 ccgacaattt gtccgtcctt tacgacaaca gcgccgacga gcggattgga ttcggtctgt 1884361 ccttcgccct gcttcgcaag atctaaggcc agcttcatat aatactcttc catttgtttc 1884421 cctcccctct tttgttattt accgtcaaaa aagccccgaa tttataaaaa attcggggct 1884481 ttaggtattt tacgcaatag gaaataacac tatgcatttt taaacatttt gcatagcggc 1884541 tcatcatcct tctcccatcc agactttcac tgtcggcttc agcttaaact gaatccaccg 1884601 cgtgcttatg cacacgggtc acgggctcta aagcaaatgt gctttactac cgccggtcgg 1884661 gatttccacc ctgccccgaa ggatacaatc tttattcatt tgtccttatt ggttattata 1884721 gcgatccttt ttaaagtacg caatgaaata aacttacaat ttgagaaaaa caaaacatca 1884781 cccttcgatc cgaaaggtga tgttttttaa tcattcactt ttgcaacctt gattaatccg 1884841 tcgatccgct ttgatttgct gaagtaagcc ttaatcttgt caccttcttt tatatcagat 1884901 aaatcctgat ttaatttttt tccgttgaag atgattttcg ttccgttttc tgctactcca 1884961 tgatactctg agccgtcaat tttcgtcact ttatattcct ggatggtgta ttcctcttct 1885021 tccgaggaca aggtttgtcc aattgctgtc ggaacatcct tcagctcaat atcatttatg 1885081 tacatataac cgcctgcaag taaaagcaaa agcactaaca gaatggtaat cttggttttt 1885141 attcttccca tttctaaacc tccagccaat atgaatctat tcattcatat gagttattcc 1885201 tttttttcat gaataaaaaa ccgtaaattc tcgtaaatta ttaatataac gatgcataac 1885261 gggaatatgt ttcacatttc tgcaaaaatt tcttttctat agatatacga atttatgttc 1885321 tgtttttagg ggatgaccgt aaaaaagata taaaaaaagc agccccaatg ggaagctgct 1885381 tgatcctaat ttgttttgcg catttcgtta aacgggtaga aaacaaactt tgacgtaccc 1885441 gcaatttgtt ttttcgtgaa gaggccaagg ccgttacggc tgtccatgga attgcgacga 1885501 ttgtcaccca tcacaaaata cttgttatca ggcactttaa ccgggccgaa atcatcggtc 1885561 aaatggtcaa aaccgtcctg tttcgctctc tttttattag ccgccaaata aggttcgtcc 1885621 acctttttcc cgttgatata gagctggtca tttttcatct caaccgtatc gccgggaagg 1885681 ccgataatac gtttgacata gtgaacatca tctccgttta acacgacgat gtctcctcta 1885741 tcaaactcgc cgatgtattt gactgtcata ttaacaaaaa ccctttcacg gttgtgaagt 1885801 gtaggataca tagagtcacc atcaacgaca tacggcgcaa aaataaagtt gcggatgagc 1885861 aaagcaagaa cgacagcaat cacaattgct tttgcccatt ctaatattga ctttttcttc 1885921 gaaacatttt ctgatttcaa ctgatttcct ccaataaaca acggtcttca atttatgtta 1885981 tcacgaatcg aaaaaaaatc ccattaggac cattgaagtg attttacaaa ctgttaatct 1886041 tcatcttcta cccacatcat gcctattttt tcttgtcgat cataactagg cctgaaaata 1886101 ttgaaagaaa tgaatcgcat aattcagaag cgatggactc agaagaaaga gagttctcat 1886161 atgcaaaatc tttagatcgt atataaagca tgaggttacg ggcagtttgt tcatttactg 1886221 cattccattg atctcccagt ccatgatacc catggcactt gacaaaacaa ttaacgtcat 1886281 gaaggttact ggaatgtttg cggcaaccta tttcacaggt gataaccgca ccccgttttt 1886341 tgctttcata atatgtttaa aatcattcaa gctcgaaaac atggatcagc ctccaaaaaa 1886401 taaatccaat atattcccgg cagttgaaga ctctttatta taaaactctg aatatccgca 1886461 gttcttacag taaaccacta gaaatcggtt atgctgcacg tcaaacagct ttgataatcc 1886521 cgtgccggtt gtagctattt ctttttgtcc ggcttcagta ctaccgcatt ttatacagcc 1886581 tttgttgttc atatcgcgat ctccttttca ttacatcacg tttgtttgat ttattttact 1886641 acaaaatatc aatcccaatg acccgtacta ctttaaagtt tacttaattt tgattacata 1886701 ctaattgggt tcgtttctca gcttggtaaa tcttctggag aaacggaaaa gctccatgac 1886761 caaaacattc aaactcagcc aaacaccgcc gaaggcgtaa cccgcagcaa catcactcgg 1886821 atactgctca taaagtacac acggctcagc ccgatgagga ataaaacgat aataaacaaa 1886881 aaaatgcaac agtttgcaga cgcgtcttgt gagaatgacg aacaaaaaga taagcacaaa 1886941 aaccaaaaat gacaaatgcc gttaaagtct gttcgctcgg gaatggatat aatacatgac 1887001 tttccaaagg agcgtgaaca ggatgaaggg aatgaaagag ccgtctgatt ccctcttcat 1887061 aaagctcccc accaatgact aggaaaaata agaaagagag ttcgattttc cgatcttgcc 1887121 ctctgaatac cgtccaaaaa aaagttagaa caataacggc taacagaaca cctctcgacg 1887181 caaaagcttt ctgaattgca gctgggccca gtctataccc gatccaatac gacatgctca 1887241 ctcccacagc tccccaatcc ggccgctaac atgcttagca cccagtttaa cttttcttga 1887301 aacacgagaa caccggcaaa ctctcccggt ccaagtaaag ctagaagctc taacatcaag 1887361 acaataaaca agacggcata tccgtactgt tcgagcaacc ccgtcaaaac ttgcatgtga 1887421 ttctccttaa acttttttgt tcttttatca ttcccaatcc actttttgta taatcagcac 1887481 aattttatct tcagtcgtcc aacaacattg tctatggcgg gatcttctct catacattct 1887541 tttttgacat aggaggagca atagcatgaa atgggaggaa acaaaagata cgcagggagt 1887601 ttgccaaaat tttgggcagt tcgttctgcc accgagtcag gtgtttgttt gcccacctca 1887661 tcccttgtca attccccatt tttcccgttt gaggttcgaa atggtaaagt atttcactta 1887721 gtttcttaca tgaagaggta aattctttgc tcaccgaact aggatagcgg cgtatggcga 1887781 tttctacatt gcataaccac tggttattta gtgagccgtg agcaatgtat atgcactttg 1887841 agtcagcaca ggatgatcct attacattcg ccagaaaagc agctgccgca ttcagagtag 1887901 ttaaaagaat agacagatat ctgggcttcc ggaagcttta aaggaggctc ttttttcgag 1887961 catttttata aatcaataaa aacaggcatc tcctaaatat ttttgccgat aagtttacgc 1888021 taatcaactc tagcactaat acatataaaa aatagaatga tatgaaagga gacttgatag 1888081 tatgattgat tatcctatta atataaacaa cgtttccggg aacagtgtaa ttaacgtagg 1888141 cggcgctttt atgatcaggc ctttaacttt gtccaaatct gtgtttggct ccggaggttt 1888201 aaacacagga attgtctttg aaaataactt tgtaagcaaa gctaaaatga ttaatcatca 1888261 atttactgat caaaacgtca ccaaaacttt ttaatgtatt caatacacgg gggtcactaa 1888321 ctaaacacct ggttttgcca accgccatca gcattcggcg gttttttatt gaacattttt 1888381 ggccaataaa aaaagcttcc tctctaagag gaagcctttt gcctgccgat tagccttcta 1888441 cacgaacttc tttcatgaca tcgccattag acatgttttt cgcgaattct aatccgcttg 1888501 ttactttacc aaatacagtg tgaacaccgt tcaaatgagg ctgtggctca tgaacgatga 1888561 aaaattggct gccgccagtg tcttttccgg catgtgccat agaaagtgcg cccgcctcat 1888621 gtgtatgcgg gttgccttct gtttcacatt tgattgtgta tcccggaccg cctgtaccag 1888681 ttccgtgcgg gcatccgcct tggctgacga agccagggat cactcggtgg aatgtaagcc 1888741 cgtcataaaa gccttcgttc gcaagctttt caaagtttgc aacagttcca ggtgcagctt 1888801 caggataaag ttcaaattca attttgttcc cgtcttctaa taaaaagtaa cctgttttca 1888861 attgtatgcc tactttcttt attttaattt tcaaaggaga ttatgtatag gttatagcct 1888921 gtctctcctt gtcgcggcta ttataccaca cctttcgggg gaaaacgaat ctcccgagct 1888981 ttactaaaaa ataaaaatga aacctgaatc tctttatctc cgtctaacct aacggaactg 1889041 tatttttcat gattcaggtc ctcacaaagc agcactatcc agctgcttgt gaaattgaag 1889101 gaggtcaaac tgctttgaag aaaatttgga ttggaatgct ggcagcggcc gttttgctgc 1889161 tgatggttcc gaaggtcagt ctcgcggatg ccgcagttgg agatgtcatt gtaacactgg 1889221 gtgctgattt gtcagaatct gacaaacaaa aagtgcttga tgaaatgaat gtccctgata 1889281 atgccacaac ggtaaccgtg accaataagg aagaacatga atatttagga aaatatatat 1889341 cgaacgcgca aatcggatcg agagcgattt cttcatcgtc aatcaccatt gccaaaaaag 1889401 gctccggatt gaatgttgag acccataata tcagcggcat cacagatgaa atgtacctga 1889461 atgcactgat gacagccggt gttaaagatg cgaaggtgta tgttacagca ccgtttgaag 1889521 tatccgggac tgccgcttta actggattga ttaaggcgta tgaagtttct tctgacgaag 1889581 cgatctcgga ggatgttaag caggtcgcca accaagagct tgtcacgaca tcagagcttg 1889641 gagacaaaat cggtaacgaa aatgcggcag ccctgattgc aaaaatcaaa gaagagtttg 1889701 ctaaaaacgg ggtgcctgat aataaagctg acatcgaaaa acaagtggat gacgcagctt 1889761 ctgatttaaa cgtcacactt acagacagcc aaaagaatca gcttgtctcc ctattcaata 1889821 agatgaaaaa cgctgacatt gactggggac aggtcagtga ccagctagat aaagcgaaag 1889881 ataagattac gaaattcata gaatcagatg aaggcaaaaa cttcatccag aaagtcattg 1889941 atttcttcgt atctatctgg aatgcgattg tatctatatt caaataagaa aagcgccgaa 1890001 aaatcggcgc tttcttttat tgctttacac ccgttttaaa tggcagatca agttttacaa 1890061 tatcttcgta tgtttctcgc ttcacgacta aatgagcctc accgttttcg acaaatacaa 1890121 cggcgggtct cggaatacgg ttataattgt tggccatgct gtatccataa gcgcctgtac 1890181 aaaaaacggc aagaagatcg ccttctttta cttccggcag gtcaatatcc caaatcagca 1890241 tatctccgct ttcacagcac tttccggcaa ttgataccgt tttgtcatgc gcttctccga 1890301 tcctgttggc tgccgcagct tcatatttag cttggtaaag cgcaggacga atattgtcgt 1890361 tcatgcctcc gtctacagcc acatattggc ggacacccgg cacttctttt tgagagccaa 1890421 ccgtataaag agttgtgcct gcgtctccca cgagagaacg gcccggttcg atccaaattt 1890481 ccggaatgtc aaaaccgtaa cgggaagcat tttctttcac agcttcgata attttttcaa 1890541 cgtattcagt ggcatgaagc ggttcatcat cttccgtata acgaatgccg aaacctcctc 1890601 caagattcag caccttggat acaaatgaat atgaatctct ccattcgtct agttttttga 1890661 agattttttc cgctgctaac acaaaaccgg ccgtatcaaa gatttgcgag ccgatatggc 1890721 aatggacacc cagcagctga atgtgttccg attgtaatac ttgttcaatg gcccgttcag 1890781 tttgtccgtt atgaagatcg aaaccaaact ttgaatcttc ctggcccgtt gtaatgtagt 1890841 catgcgtatg cgcttctact ccgggcgtga tccgaagaag aacatcgatg gagtgacccg 1890901 tttctttaca taggtcttca agaagcgcga tttcatagaa attatccacc acaatgcagc 1890961 cgatgcggtg ctcaagcgcc atccgcagtt cttccctgct cttattgttt ccatgaaagt 1891021 ggatgcgttc tgccggaaag cctgctgcaa cagccgtata tagctctcct ccggatacga 1891081 catctaaaga aagtccctct tcctcagcga gctgaatcat tgcgactgat gagaatgctt 1891141 tgctcgcata tgccacctgt gctttcagcc ctgcagaaat aaacgcctgc ttaaagcttt 1891201 tagcacgctc acgtattaaa gccacatcat atacgtaaag aggtgtacca tatttctccg 1891261 ctaaatagag agcatccaca cctccgattt ctaaatgacc atgttgattt tgtctgcttg 1891321 tgccgtgtaa gaacaatgtc attccctctt tctccgctta tggatgaaag gacagtttta 1891381 tggactgtcc cttcataatt aagacataca ttatcatact cttcagtcag tttcaatgcg 1891441 attatgaatt ggtaggctgc cttaagcgat ttttggggtg aacgatgctg ggtcttactt 1891501 ttgcgccagg tttcgctgtg cggacaagaa cctgccacag cgcctttccg ttaaagggaa 1891561 tcagcggcca taagtacggt gtctgaaggg atttgatgct tgccatggca ataattagca 1891621 ctgtaaatcc gatgacgagc ccttttatat gaaataaagc aacgagtatc atgaggacaa 1891681 gacggctcat tttgtttgcc aagcttaatt cataactagg cgtcgtaaag gttccaatcg 1891741 ccgcaagtga gacgtacaga atcacctcag gagaaaaaag gccgacctca atcgcaatct 1891801 gcccgatcag aacagcggca attaaaccca ttgctgtcga taaagccgtc ggtgtgtgaa 1891861 tggcagccat tctgagaaac tcgattccta agtcagctaa aaatatctgc aggatgatcg 1891921 ggatatgcgt atctttattt aaaccgataa atttcatgtt gtccgggagc agatcaggct 1891981 gaagcacaaa gagaaaccag atcggaagaa ataaagtaga agcaagaata ccgaaaaatc 1892041 ttacccgagc tcgtggtcat tcggcataat tacttaaatt ttgtccagtc tcccatcgtc 1892101 cgctttaaga atgtgataaa cccggctttc ttcatatctt cttttgcagc aacaggactt 1892161 tcagcgagta cttctccatc ctttttcaga acaagagtgc caagctcttg gcctttttga 1892221 atcggagcac taatattgtc cttcatcttg atttcttttt tcacatcgtt catatcctcg 1892281 ccttttttcg tcaatattga aatcggctca gatgtagtga gttcgataaa tttttgtttc 1892341 ccttttttga cctttacttt tgctactgtt tgatttcgtt tatataaagg atgcgtttca 1892401 tattggctaa aggcgaagtc aagcattttt gtcacttgcg cgtttctttc tttaggcgtg 1892461 ctcgctccga atacaaccgc tatggcccgc atgtttcctt ttttagccga agcagtcaga 1892521 caatatttcg cttcgcctgt atagcctgtt tttacgccgt ctacaccagg ataaaatttg 1892581 ataaggcgat ttgtatttac aagccaaaac tttttatctg tattttcacg cagataatct 1892641 tcatacgtgc cggtaaactt cgtaattgat tcgtatttca ataattcctt agccatgatt 1892701 gccatgtcat aagcagagct gtagtgtcct tcctcggtca gtcctgttgg gtttttaaag 1892761 gatgtatttt tcaatcccag ctcttttgct tttttattca ttttcttcac aaattcttct 1892821 tcagagccgg aaataaattc agccatggcg acggaagcgt catttcccga agcgattgcg 1892881 atgcctttca gcatttcttt gacagtcatt tcttcgccgg gctcaaggaa tatctgtgag 1892941 ccgcccattg acgccgcatg ctcgcttgta cggaccttat cactcatttt gattttgcct 1893001 ttatctaaag cttccataat caaaagcatc gtcataattt tcgtcatgct tgcaggcgcc 1893061 agtctctcat tgctgttctt gttgtaaagc acttttcccg tgtcacgttc tatcagcacc 1893121 gcagacttcg cttcatgagc aagctccgat gtacgttttc cgtcttgttt tgcaaatgca 1893181 gacggtgcaa atgtaagcag cattatacca atcaacaaag tggataaaag acgtttcatc 1893241 tcaaaagccc tccatttcat aatccttttt attttttcca agcgtgatgg ttttatacgc 1893301 cactgatgga aaatgtttcg aattttgggc ataaaaaaag acagctgtgt gatatcagac 1893361 acagctgtct tttggtcctg cattgattca tatttattcg tactgagcga cgatcgcttt 1893421 aacaagcttt aagaatccag cttttacttt ttcggtcact tccataactt catcgtgact 1893481 taaaggctga tccagaattc cggctgccgc gttagagatg caggaaatgc caagaacccg 1893541 cattcccgca tgattcgcta caatgacttc cggaacagta gacatgccga ctgcatcaga 1893601 gcccatcgtt cttaagaaac ggacttctgc cggtgtttcg taagaaggtc ctgtcacagc 1893661 agtgtacacg cctttttgaa ttgggatatt aaggtctttc gcaatctttt cagccaggct 1893721 ggacagatct ttgtcatagg ctgaagacat atctggaaat ctggcgccga aatctgcttc 1893781 gtttggcccg attaacgggt ttgttcccat aaagttgata tgatcggtaa taatcattaa 1893841 atctcccgca cggaattcag tgttgacacc gcctgcggca tttgtcacga tcaacgcttc 1893901 cacaccgagc gctttcatca cgcgtacagg gaatgtgact ttctccattg agtagccttc 1893961 ataaaaatga aagcggccct gcattgcaat gacggaaact ccttcaagag tgccaagcac 1894021 aagctgtccg gcatgccctt caacagtaga taccgggaat tcaggtatat cttcatattt 1894081 cagcttgacc ggattttcga tttcgtccgc caaaatgcca agacctgagc ctaaaataag 1894141 gccgatcttt ggagattccg gcaggttttg tttaataaaa gcggctgcgc gttcaattct 1894201 gtccttcaag aaacagtccc cctattgtaa taaagataaa aagcttttcc cgtatttcgg 1894261 tttatttgtt tggaaattat cagcgatcgt tgcgccaata tcggcaaatg tatctgcaag 1894321 cggcagcatt tgcgctttct tatgtttttt gctgtaagcg agaatcggca catactcgcg 1894381 tgtatggtca gtcccatgat gaatcggatc attgccgtgg tcggctgtaa taattaacag 1894441 atcgtcttct ctcatttttt caaacacttc cggaagccgc gcatcaaatt cttcaagcgc 1894501 gcgtccgtag ccttcagggt cacggcggtg tccgaataac gcgtcaaaat caacaaggtt 1894561 cgcaaagctc agacccgtaa aatcttctcc cagcgtatcg atcaccttgt ccattccgtc 1894621 catattagaa accgttctgc gtgaagaagt aatgccttct ccgtcgtaaa tatcagagat 1894681 tttaccgatt gaaatcacat ctaagccgca gtctttcaat tcattcatga cagtgcggtc 1894741 aaacggcttc agcgcataat catggcggtt tggcgtccgt ttgaattgac ccggctctcc 1894801 gacgaacggc cgtgcaataa tgcggccaac catatatttc ggatcaagcg tcagctctct 1894861 cgccgtttcg caaatgcgat acagctcctc aagcggcaca acctcttcgt gagcggcaat 1894921 ttgcagaaca gagtcagcag acgtgtaaac aattaaagcc cctgtctcca tgtgctcctg 1894981 gccaagctca tccaaaatcg ctgtgccgga agccggcttg tttccaataa ttttgcggcc 1895041 agatctcttt tccagctctt gaagcaattc atcaggaaag ccttccggga acactttaaa 1895101 cggtttatca atgtataaac ccataatctc ccaatggccg gtcatcgtat ctttgccgtt 1895161 tgacgcttct tgcatttttc cataataggc aagcggatgt tctgtttttt ctacaccttt 1895221 gatatcttcg ataagaccaa ggccgagctt tgccatattc ggcatatgta atccgttcat 1895281 atgctcggca atatgaccga gcgtatgagc gccttcgtca ttaaagtcag cggcatccgg 1895341 cgcttcgccg attccgactg agtccatcac aattaaaaac acacgattat atttgtatgc 1895401 aggcatcttg aaagcctcct ttttttctat acgtctattg tatcgctaag aggtctgaca 1895461 actcaagtat aaaccgtttt cattcccgtt gacaatgtat ttggaaataa tgagaaactt 1895521 caatattttc tgtcgctcta aacaaaaaag ccgcagccac ctgcggctat gctcgcggat 1895581 gaaactgctt gtacacatcc ttcagccttg ttttcgtcac atgcgtataa atttgcgtcg 1895641 tggatatatc cgcatgaccg agcatttcct gcaccgctct taaatctgcc ccgttctcaa 1895701 gcagatgcgt cgcaaaggaa tgcctgagtg tatgcggagt cagctctttc ttaatgccgg 1895761 cttccaatgc gatttttttc aggttcttcc aaaatccctg gcggctgatc tgtttgccgt 1895821 gatgatttaa aaagagggcg tcagatacat tattttttaa cagttttccc ctggcttttg 1895881 tcatatattc ctcaatggcg gaagcagcgg cttcaccgat tggcacaatc cgttcttttc 1895941 ttcctttgcc gaagcatcgg ataaacccca tagataaatg aacatcagcc gttttcaatt 1896001 caatcatttc actgactcgt atgcctgtcg cataaagcag ctccagcatt gctttatccc 1896061 gatatccgaa agggctcgtc agcttaggcg tgtccaataa ccgctcgact tcattgagcg 1896121 cgagcacctt cggaagcgcc cgttccgtct tttgtgtttc gatatgaacg gaagggtcct 1896181 tatccgttac tttttccctg agcagaaatt gatgaaaaga gcgaatggat gccaaatgcc 1896241 gcgccgatgt cttgccggat ttccccgagt ccttcaaatg ctttaagtat tggataatat 1896301 gtatgcgggt aacgtgattc caatctgtaa catgaagggt ttctgttaag tagagagaat 1896361 agcttttcaa gtcacgttca taggatacga tcgtattttg agagagccct ctctctacca 1896421 taacgtagtg gatgaaatcc tttatttgat ctttcactct tgatctactc cccgttttgg 1896481 taaaaaaaga tcaaccggtc gaaccatccg cctttttcat cctgatccat ttcaacaact 1896541 tttacagcgg agccttccgg tttatcatac cgatgatagt tttcatactc ttgattcacc 1896601 catatcatag cataatagaa caaagcggta aaaccggtaa acaggatgaa aactttcaat 1896661 gcatcgacag ctgttttcag gaatcttccc atgtcctaat cgatcctttc cctatggttc 1896721 cagttatata aaccatatgc caaatcagaa aggttttata catagaaaca gcaaaaaacc 1896781 ctttccccat gagaaaaggt tcgcgctcgg caccgtctat tcagtttctt ttccgttaca 1896841 gcggtggcaa atgccgtgaa acgtcaatct atgatcttta atcttaaatt tccaatcacg 1896901 ttcaatgatt tcttccacgt cttcaagcaa atcttcttca atttcatcaa cggctccgca 1896961 ctccatgcac accaagtggt gatgaaagtg agctgcgccc tctttccgaa ggtcgtaacg 1897021 ggacacaccg tctccaaagt taattttatc tacgactttt aattcagtta ataattcaag 1897081 cgtacggtat actgtagcga gaccgatctc aggagatttc tcttttacga ggaggtatac 1897141 atcttctgcg cttaaatggt cttcttcgtt ttcaagcagc actcttactg tcgcttcacg 1897201 ctgtggcgta agtttatagc tggatgagtg cagttgtttc ttaatacgat caatacggtt 1897261 ttccatgtct ttccctccta cgccgcattc catgactcat tataacaaaa tacgcgcaga 1897321 gttccaacta taattattat aaactgataa ataaaatggt tttcttttaa taatgatttt 1897381 aaaaaagtct agatgtaagc ttttccatta aaacaggaga taagtatgct tcaaagagag 1897441 atgaaatcag cgctaaaaac agaatgacca gcagcacaaa ggcataccgc ccgaaccatt 1897501 gaatcggcgc gtcatgcagg cttcgtttca cgaacagctg tctgattaac tttaaagaaa 1897561 acgcaattgc acatgtgccc ataatgagat aagccggaat cagcagcaca ttttgcggca 1897621 aaacggagac aaatgatagg aaaaacccgc ttactcccat ctgattgact aggaacccga 1897681 cagtaaagcc gacgacgatc cctttcagaa agatcataat gaaaataatc ggcatcccaa 1897741 tgacggaaat tcccagtatc cacatcaggc ctaaatactt tgcattatga aagatacttt 1897801 gcccaaacat atcagctgaa cttgcctgtt ttccatccga aagctgtcca aaaaattgac 1897861 ttaagtagta gtataaatct tctttctggc tgatggtcat actgttgaca ataatcgcgc 1897921 caaagatgac acccatgaaa aacagcactg acacaaatat ataaagagag agatgatctt 1897981 tgacatgcct gagaaacatg tccttataag agatttttcg cataccgttt cctcccgccc 1898041 gctctagtga tttgatttaa tagattgtat gaaagaaaca gaaaaacatg ccctttttca 1898101 aaaagaaaca atagagatga atgctaggcg gctttttggg gcacaaaaaa atccttatca 1898161 tcaactgctg tatgatcata aggattctta tgcttccgtt tattcaaaat ctcttttttg 1898221 ctttttgtca ttcttccatg tgtgctgaaa gatggtgtgc tgcctcttga taataagacg 1898281 tcacgtccgc cgtttctcaa tcgatgcccc cgcttctttt tcgcttggct ttttgccatg 1898341 tgatcactcc cttttttatt ttcatagtaa tgataacaaa attgaacaat gataagaaaa 1898401 aaacagcacc tgctacgaca ggtgctgttt agctacattt atttcactgc tgtaagagct 1898461 gcatgctcga cagctgctgc taccgcatga tggacttttg aatcaagcgg ctgagggaca 1898521 acatcacctt gtttagtgca agctgcgatg gcctctgctg ctgcgacaag catatcatga 1898581 ttaatctccg tgctttttgc gttaagcgct cctctaaaaa tccctggaaa accgagtaca 1898641 ttattaacag aacgcccgtc agctgcatat gcggcgccag cctgcagtgc ggcctccggc 1898701 tcaatttccg gcttcggatt cgataaagcc agaatcactt gaccagaacg tacaaatgcc 1898761 ggttttatta aacccggaac gcccgttgta gcaatgacaa tatcacatgt ttccataagc 1898821 tcctcaatac tggaaactgc ctgtccgccg tattgttcga gacggttcat tgctgactct 1898881 gatttgtctg ttccgtatac agcattcaca ccataagcca tgaacatccg gcagatggcc 1898941 acgcctgctg cgccaaggcc gatttgcccc actttcgctt ccttcaggtc aacccccgca 1899001 ctcctgcatg ccgaaatggc agctgccagc gtcactacag ctgtaccatg ctggtcatcg 1899061 tgcataacag ggatgttcag ctcctctttt aggcgatcct cgatttcaaa acaatgcggc 1899121 gaaccgatat cctcaagaag gatgccgcta aagcccggag aaatatgttt tactgttttg 1899181 atgatttctt caggatcact cgtatcaagc agtatcggaa tgccgctaat acccgccagc 1899241 tgatcaaata aagcagcctt tccttccatg acaggcatgc cagccacaga gccgatattc 1899301 ccaaggccta aaattgcggt tccatccgtt acaattgcaa cagaattgct gatcgttgta 1899361 taaatagaag ctttttcagg ttctttttcg atcagtcggc acacgtccgc aacacctggt 1899421 gtgtagacac gtcccagctc tgccagtgaa cggatcggca ttttgctttt catttggatt 1899481 tttccgcctt catgtgcgga caggacttca tcagatacgg tgtgaagcct gatcccttct 1899541 ccgagggcct gtacagccgc gatcacttcc tgaagctgtt cttcattctc cacttgaacg 1899601 gtaatattcc gcattgtgta attgggtccg acttttaccg tctccacttc accaatatcc 1899661 ccgcccagaa ggccgatggc cgtagccacc cttccaagat ttccgggaac cgaaggcgtt 1899721 tcgatcatca gtgtccgaat catgtgtttc gctatcattc agtgatcctc ccctattagc 1899781 ctagtttttc ggctttaact gtattgtttt tcgtatacca tataaatttt cctgtataac 1899841 catagataat tgcaagacct attgctacaa aactgagcca cataaacggc agataagaga 1899901 aggtagaaac acctaaaata ccagccatgt aaatcccatt atcagaccaa ggaaccatcc 1899961 ccgaagtcaa tgttcccccg acctctgagt tacgtgataa cactcttctg tccagatgta 1900021 agcgatcata gctgtcttcc ataattttcg gagtcaaaat aagagataca tacatcgcac 1900081 agccgaagat gtttgctaaa aacgctacga tcagtgtaga caatgtgaca ttgccggctg 1900141 aagttaattt cttttcaaac gttgaaacaa tgacttttaa cacgccgagt ttctcaagca 1900201 gaccgccaaa accaaggcca aagatgatga cgacgagaga atcaagcata ccgacaattc 1900261 caccgcggtt taacaagccg ttcaaaaatt caacatccgt tttaatagag aagccgttgt 1900321 acgcagttgc aatcgcatgg gcaatatcca ttccttggaa aacaacagcc cagattgcac 1900381 cgagtaaagc gccaattacg ataactggca tagatggctt tttcatcgcc aataagacta 1900441 tgacgagaac tgccgggatc agcatccaaa tatgaatgtc aaacgtgttt tgcaaagatg 1900501 attttaagaa ttcaacttta tcaagatcaa tatttttccc gccgtacata aatccaacaa 1900561 ctgtaaagag tatagctgta atgacataag caggtattga taaataaagc attgctctca 1900621 cgtgagccaa tacatcgact tttgatagtg aagaagctag aactgtactg tcagacagcg 1900681 gagacagctt gtccccaaaa taagcacctg aaagaatagc tcccgctact agaggaagcg 1900741 gaatgcctaa cccctctcca attgcgatca tggcaatgcc ggcagttccg actgttcccc 1900801 atgacgttcc tgttgccaca gacataatgg aacaaataat taacgttgcc agtaaaaaga 1900861 tacttgggtg aataaattcc agtccgtaat aaatcaaagt cggcacaacg cctccggcaa 1900921 tccatgttcc gatgagcgcc ccaactgaaa cgagaatcag tacggcttca aggccatttg 1900981 atatcccatg tacaatcgca ttttgtaaat ctttataaga ataaccgagt ctaataccta 1901041 aaagcattgc aataaaccat gaaacaaaaa gcgccagctg tatcggcaag tcgagaaaga 1901101 ctgtaaacga tagaacaagt gctaaaaata ctcctagtac aataataatt tcaaatagtg 1901161 ttggcaatct tacatccttc aaaagaagtc ccccttcatg taaaagctaa aacgctttca 1901221 atatatagtg caacacgtat actatacttc ctcatcccta tgttgtaaac agcttattca 1901281 tccgactatt cggagatgaa taagctgtat tttatacaaa ttttattttt ctaatagttc 1901341 tttccctgcg atacctggtt tggtcatctc atatgggttt aaaataatat ccaattcttc 1901401 ttcagtcagc acatcatgct gcagacaaag atcccggaca gattgccctg tcataattgc 1901461 ttccctggca attctagctg ccgcttcata cccaagatgc ggattgacag ctgtgatcac 1901521 gcctgcgctt ttttctacgt attgcttcat acgcttttcg ttggcttcaa tgccttttaa 1901581 gcagttgtca gtgaacgaac ggaagccgtt gttcatgatg ctgatggatt gaagcaaatt 1901641 aaagacaagc acgggctcca tgacgttcaa ctcaagctgg ccggcttctg aagcaaggca 1901701 gattgtattg tcatttccga taacctggaa cgcaatttgg ttgatcagct ccgccataac 1901761 cggattgact ttccccggca taatagatga acccggctga cgtgcaggca gagaaatttc 1901821 cgcaagtccg gcgcgcggtc ccgacgccat taagcgcagg tcgtttgcga tcttcgacat 1901881 gttcatcatg cagactttta atgaagctga tacctctgta taggcatctg tattttgtgt 1901941 cgcatcaaca agatgatcag cgccgacaag aggaagcccg ctaatatcag caaggtgctt 1902001 tactacctgt ttgatatatt caggatcagc gttcagccct gtaccaacag cagttgcgcc 1902061 catgttgact tcatacaggt gctggcgcga ttgcttgatt cgtttgatat cacgctcgag 1902121 aacacggctg taagcttcga attcctggcc aagacggatc ggaaccgcat cttgaaggtg 1902181 tgtccggccc attttaataa cagagtcaaa ctcctgtgct ttttgcttaa acacactatg 1902241 catatcttcc attgttttca gcagtttttc taagagcttc aatgtggaaa tatggatagc 1902301 agtcgggaac acatcgttcg tagactgtga catgttcaca tgtgtgtttg gacttaaatg 1902361 gatataatct ccctttttat gtcccatgat ttcaagcgcc cggtttccga taacctcatt 1902421 cgcgttcatg ttcatagaag ttccggcacc gccctgaatc ggatcgacga taaactgatc 1902481 gtgccacttg ccttccagaa tctcgtcagc ggcttgtacg atagcttggc caattccttc 1902541 atacagccgt ttcacgtcca tgttggcaag agccgcagct tttttcacaa tcgccagtgc 1902601 gttaatcatt tcctcatgga ttttgtatcc tgtgatcgga aaattttcag aagcacggag 1902661 cgtctgaatt ccgtaataaa catctgcttc aatttgtttt tccccaagga agtctttttc 1902721 cacgcgatat tctttttggc cgtttaacat aatctttaac cttctttctc tttgctggtt 1902781 atcgttttta cattttacag gacaacgtca tcagctatcg gcgtttccat aattctcttg 1902841 acgacaggaa gatccgaaga ctgacctagc gcccacatca attttggcac aattgcttct 1902901 gtgttcatat ttcttgatcg gataattaag tcttggttga ctctgcggcc aacctcgtaa 1902961 atgctcatgt cttcgccttc ttcaagacat tgagtcgtaa tgacgacgac aatgccgctt 1903021 tcgatcagtt cattcacttt tgacaaaatg tctctgcctt caaacggcac tcctccgctg 1903081 ccataactct caatgacaat tcctttgtac atgcttttca gggcatcaaa catttcgggc 1903141 tttaagcctg gatgcagctt cagcagacat acatctgtgc atagtgaagt gtcaactgtg 1903201 aaggtgtcgt tctcaggttc cgttacttgt ttgttgtatt cgatcccgtc ttcattgata 1903261 aaagcgatat atgggtaatt gatgctttca aatgcgtcgt agcttttcgt tcttaatttg 1903321 atcgcacgcg ttccctgaat gactctgccg tcaaacacaa cataaacgcc gcccacgcct 1903381 tcacaggcaa atcgaatggc atctgtaata ttttttttgg catcggtttt ttggaacgtg 1903441 atcggaatct gcgagccggt gatgacaatc ggctttttgg catgctgcag catatacgat 1903501 agtgcggcag atgtataggc cattgtatct gtaccgtgag taataacaaa cccgtcatag 1903561 gcatcataat tttccttaac ggcttctgct atttccaccc agtattcagg ctgcatattg 1903621 gtgctgtcta tattcataag cgactgagtt tccattgtgt aatcgttatc aagttttgat 1903681 acgtaactta ataattcatc agccttgact ccgggagcca gcccattttc cccttcaact 1903741 gaagcaatcg ttcccccagt tgtcaacatc aataattttt tcataccatg cacctcttca 1903801 ctgtatctaa agatgggttg cgagaaggta ttcgcttttc gcatactttt aatgcaatta 1903861 tagacacgga aaataaaata cgcaagacat tattattcaa ttcgcgtaca cttcctaata 1903921 cctatatgat ataatcagct caaggtgaaa aaggagcgga agttcatgaa tctagatcgt 1903981 ttaactgaat tgagaaaaaa gaaaaattgg tcgcttcaat atacagctga ccttctcggt 1904041 atcgcaaaaa gcacatatgc cggctacgag tcaggctacc gacggccttc acttgaagcg 1904101 cttgccatgc tggctgacct ctttgacaca acctgcgatg aacttttagg ccgcgagaaa 1904161 caaaagcaga ctgctcctca ggccatagaa ttggccacgt ggagcagcct cgactttacc 1904221 atttctgttg atggccagcc gctgagtgaa gatgaaatca tccagctgat tacctttata 1904281 cgcacaaaaa gaaaagtaca ggaggaactg agttaatctt tagctcacgg tttaatttta 1904341 ccgtaggttc ctcctcctcc ggctttcaat tccagttttc cggatctcgc ttttacgata 1904401 agcgccgcgg ttttcggcgg gacaacgcga gccaaatctt cttctgcagc ctcatgaaga 1904461 acagccattt ctgttccgaa ggcttttttt agtttgtcca gcgttttcgg gcctacaccc 1904521 ggaacaaatt gcagcgggat ctgatgtaca tatcgcggac gcgggacgcg aacttcaagc 1904581 tgatcactca attcacgcaa tctatcgctg actcccttgg taaatctggc ttttccgcaa 1904641 ttcgcgcacg ctgtttcccc gcttacagca ggctctccgc acgcttcgca agccgtctga 1904701 taatatttcc ccaataacgg gtccaagcca taatttgcga taattttcct gtcatcttgt 1904761 ccctttaatg caagagcaaa ttcagtaaaa tcagctgact gcacatataa ttcattatat 1904821 tctctgccga ttttccccaa cgaatgcgca tcagaatttg ttaaaaaagg atacggattc 1904881 aattgcgata cgtgtgatgc catgtctgta tcacagctta atccaagctc caccgcgtct 1904941 atcatagatg gatcaaaaac ctcagttaag cttgatttaa ccccttttcc atataagctt 1905001 ttatgcggcg taaagatatg ggcggggata aacaggccgc ccatatcctg cacttttttt 1905061 tgcaggttta agcccgtttc ataaatccgc tgcgagctta aatgaatatt tttcagccgg 1905121 gctgacagcc agtttgaaaa ctgtttcata tcagccagcg tcggcataaa tacgagcaca 1905181 tggatcggtc cgctgcaggc ttcatcataa atctccagct cgctccccaa taaaagagtc 1905241 gtgctgcgat aacggattcc tcccccgtca agctcgcgat attttccaga tgaaatgcct 1905301 tcctcaagct ctagaatgac ttccggagaa tgacagtcga taatgccgag gagttcaatt 1905361 cctttatgtt cactggcttc aaccaaaatt ctgtccagcg ttaatgtttt ggcgcctgtt 1905421 attttgacag cccttcctgt aaaggtccgg ccgatatgaa tgtgcaaatc cgcgtaaatc 1905481 tttttcattt ttgtgcttgg agcgcttctt tcagctgaag atactgaatc gcgtaggctg 1905541 ttttagcatc atatacttca cgcgattcaa ccagctttag cgcatcttca agcgtcacct 1905601 ccatcacttc aacaaactcg tcctcatcaa gctcccgttt ttcttcaagc acagaaagct 1905661 cctcagcaag aaaaacgtga acgatttcat ctgcaaatcc gggtgatgta taaaacgcag 1905721 ttatttttgt cagttttttt gctgtataac cggtttcctc ttcaagttcc cgaagtgccg 1905781 tatactccgg ctcctcacct ttttcaagct taccggccgg aatttcaacg atcgtccgct 1905841 caagcggctt acggaattgt ttgaccatga tgattttccc ttcatctgtg acggctagta 1905901 ccgctacagc tccagggtgt ttcacaattt cacgtttact ggctttgccg tttggcagct 1905961 ctacatcctc gacataaaga tcaatgactt tacccgaaaa aatctgttct ttggcaattg 1906021 ttttttcttc taatgatttc atttcttcat ctcccgttct gtctctatat gatgccccat 1906081 acattttatc atactagagc aaaagggggc ttcttcgtga aagtgcaccg catgccaaaa 1906141 ggtgttgtct tagtcggaaa agcatgggaa attcgagcga agttaaaaga gtatggacgc 1906201 acatttcaat atgtgaaaga ttggatctca aagccataaa agttgaaact ttagctcctt 1906261 tatattacgg tcaatacaaa gcctaaaaaa ggagtgtgca catgagaaag cgcaaattgg 1906321 gtacatctga tttagacatt agcgaagtcg gactcggctg tatgtctctt ggaactgaaa 1906381 aaaacaaagc attgtccatt ctggatgaag cgatcgagct tggcatcaac tatttggaca 1906441 cagcggattt gtatgaccgg ggacgcaatg aagaaattgt cggtgatgcg atccaaaaca 1906501 gacgccatga tattattctg gcaacaaaag cgggaaaccg ttgggatgac ggaagcgagg 1906561 gctggtattg ggacccttca aaagcttaca taaaagaggc ggtaaaaaag agccttacac 1906621 gtctgaaaac agattatatc gacctttatc agctccacgg cggcacgata gaggacaaca 1906681 ttgatgaaac gattgaagcg tttgaggaat taaaacaaga aggtgtcatc cgctactacg 1906741 gcatttcttc catccgcccg aatgtgatta aagaatatgt aaaaaaatca aacatcgtca 1906801 gcattatgat gcaattcagc ctgtttgaca gacgccctga ggaatggctc ccgcttttag 1906861 aggaacatca aatcagcgta gtcgccagag gtcctgttgc caaagggctc ttaactgaaa 1906921 aaccgcttga tcaagcttca gaaagtatga aacaaaacgg gtacttgtcc tattcattcg 1906981 aggaactgac aaatgcccgt aaggcaatgg aggaagtggc tcccgatctt tccatgacag 1907041 aaaagtcgct gcagtatctg ctagcacagc cggctgtcgc ttcagtgatt acaggcgcca 1907101 gtaagattga gcagttacgg gaaaatattc aggcagcaaa tgcacggcgt ttaaccgaag 1907161 aggaaatcaa agcgctccaa tctcatacga aacaagacat ttacaaagct catcgctcat 1907221 agcagaaaaa ccagcacctg tacgggtgct ggtttattta tattgatgcc aatccatttg 1907281 gctttcattt aggagttctt caaagctctt atttttttcg atctcttttt tctttctaat 1907341 ctgttctgct ttttctcttt tctgcctctt ttcatcctct tccttcaatt ggctcttcat 1907401 ctccataagc tttgctttga tatcggattg aaggccgtct tttagctggt gtttgtcaat 1907461 ggatttttgt tttttcatgc agacttcccc catgttttgt tttgaagcca gtttatcacg 1907521 gagcatataa actgaacaag cagactctct tctgatcact ttctcagcgt agcagtgttt 1907581 aggtataatg atcttaaaca cgaattgcct atatatttcg ttgaaaggtg ctgtgacttt 1907641 tgaagaaaat ccttttggcc attggcgcgc tcgtaacagc tgtcatcgca atcggaattg 1907701 ttttttcaca tatgattcta ttcatcaaga aaaaaacgga tgaagacatt atcaaaagag 1907761 agacagacaa cggacatgat gtgtttgaat catttgaaca aatggagaaa accgcttttg 1907821 tgataccctc cgcttacggg tacgacataa aaggatacca tgtcgcaccg catgacacac 1907881 caaataccat catcatctgc cacggggtga cgatgaatgt actgaattct cttaagtata 1907941 tgcatttatt tctagatctc ggctggaatg tgctcattta tgaccatcgc cggcatggcc 1908001 aaagcggcgg aaagacgacc agctacgggt tttacgaaaa ggatgatctc aataaggttg 1908061 tcagcttgct caaaaacaaa acaaatcatc gcggattgat cggaattcat ggtgagtcga 1908121 tgggggccgt gaccgccctg ctttatgctg gtgcacactg cagcgatggc gctgattttt 1908181 atattgccga ttgtccgttc gcatgttttg atgaacagct tgcctatcgg ctgagagcgg 1908241 aatacaggct cccgtcttgg cccctgcttc ctatcgccga cttctttttg aagctgaggg 1908301 gaggctatcg cgcacgtgaa gtatctccgc ttgctgtcat tgataaaatt gaaaagccgg 1908361 tcctctttat tcacagtaag gatgatgact acattcctgt ttcttcaacc gagcggcttt 1908421 atgaaaagaa acgcggtccg aaagcgctgt acattgccga gaacggtgaa cacgccatgt 1908481 catataccaa aaatcggcat acgtaccgaa aaacagtgca ggagttttta gacaacatga 1908541 atgattcaac agaataaaaa agcgaaaggc ctcttcggct ctttcgcttt tttatgttac 1908601 agaacgtcgg taatgccatc catattttct ctgatccatt caatcgcaag atctatcgtt 1908661 gtaaactcct gcgtctcgaa ggtcatttca tcctgcaata gccagacatc tttcttgatg 1908721 gactctgctc ctccgattga ccagtgaagc aaggtataag gatggttttg attcaggaag 1908781 gatacccacg ttttattttg tgctgtgttc ttcattgcct tcagcttttg ttccacgttt 1908841 cgcgtctcct actttactaa tatgctcatt ctggggctga gcatttcagc cgggcttttc 1908901 agcgccaatg ttttggcttt ttcattgtaa tcgatcgtca tttgatcgtc aaaaaacact 1908961 ttttgcgacg attggatata cagcggaatg ccgttcgttt ccagctgctc gcactgtccc 1909021 gttaattctt ctgccagcca gattgtcggg acaccgctta ccgcgcagcc gcatccttct 1909081 gcatcgtaac gaagctgggc tttttttccc gggttggcgt caaacgcctg ctgcagtgcc 1909141 tgttttgctg catctgtcac atgtatgttc ataaggtgaa acccccgttt tcatcatttt 1909201 cgctattgta gcatacaata ctgccattcg cattgtttct gccttttttc caccgcttcg 1909261 cattttcttc tgcagtcttg atccactcat ctttcccttg tatatactga ttgatgctgt 1909321 cagggtgctg ggccgccagc tgttttttga gaacggcgta ttctttcgct atgtttggat 1909381 gagctctgag ataatctctg aataacagat gcctttcaat agcagggttt ccctgttcgt 1909441 acatatggac atgatgagtg cgtttatttc cgcccttttg gaaataacgc ctgcccgcta 1909501 taccgttctc accttttggt gtatagccgt tggccttcat ttgttcatca aattggctca 1909561 cggcttcaat gcttctgact tcaattaaca tatcaatgat tggcttcgct gccatgttag 1909621 gtattgatgt gcttccgatg tgatgaatag cgataatctc cggcccgaac acaagtttca 1909681 gccgttcttt ttcttcatcg aaacattctg cccatttttc gttgtagaga atgatctcaa 1909741 cttttctttt cggatacaaa tgaaagaccg acagcaatag accctgcgct gctttgacgg 1909801 tttctgcctt ttggaatccg gcctgtgtat agagtgacac agccggggta ttgttctcgg 1909861 ctgtgactac ttcgattttc tcagcgtctt cattatgatc aatgacaaat tgcagaagcg 1909921 ctcgtccaat tccttttctg aaaccgtcag gatgcacaac aagcctgcaa atggtgagat 1909981 aatgcatgtt tttctcatat gaaatgacac cgatcagctt gccgtttttc cgatatcccg 1910041 caaaccgttc atgggatgct tgaatatcct ttaccttctc ttgtaaagcg ggaataccgt 1910101 caaaaccgat aatctctgtt tcctttatgt aggcggggat ctgtacggct aaaatctcac 1910161 gcgctatagt ggcttcctta tgctggagaa attcaatcat tcgtgttctc ctgaaacagc 1910221 cgctgtctgt cgacttttgc gacgcggact gcatacgact cgtaccaaac gcttcttcct 1910281 ttttcttttg ctgcttgatg ttcagtgtga tgcctccaat ggttaattgc gtccatactg 1910341 tcccaatagg aaactgtgat gccccttcca tccgcttcac gtacgctttc cacgcctaaa 1910401 aatccaggct gatccgccgc aagtgatacc atccgctccg ctgtttctcc atatcctgtg 1910461 tcattttcgc ttttgacaga agaaaaaatg actgcatagt aaggaggctc aggtgttttt 1910521 gataaaaaat ccatcatatt tccccctcat atgtttttga caaatagtac cctgtcttgg 1910581 cccgggccat catagtttgc aaacactgag atgccattta ccgttttggt gcccttttca 1910641 atatcaaacc ccaattttgt gtgatatgcg attgatacct tattcacagg tgaagtgaca 1910701 cacttcaccc gggtgcagcc cctttgtttt actgtttcga taaatacatc atacaattgt 1910761 ttcccaattt gcatttttct gaaatccgga tgcacaccgg aaaaatgaat gtacgccgtt 1910821 tcaggatcgg attgcgattg aaatccgatt aaaaatcccg tcatgctgtt atgttcggat 1910881 gtaataaagc ttgtgtcctg aaaatgctca aaaaatagtc tcggcaattt ttctttcagc 1910941 tgtctgccgc cccaccattc attcagtaca gacgttacca tttcataatc tgaagacgtg 1911001 attgttcgaa tatccattac gatttgatct ccctccgtct ggcaaaacga atgtcagctc 1911061 tttttctcac aatataaaaa ttatattttg cctggctgga attgtaaatg ccttctttcc 1911121 tgtatcatac gtttccagac tgccgaggga acaatgtttg atcattttac gcctatttct 1911181 cccccaaaca ggaggagaga ctttacagca caatatcaag cacttgatca agtttcagct 1911241 tataaagctg atcctcgtct ccttttatcc atactgcttt ttcaaactct tcataccggc 1911301 agattttccc ggtgcagcag acaatctcac cgtcctgaaa gcagctgaca gtgatatcct 1911361 gagcaaactc catcgcggcg caaagcgttt gattcatctc ttccagctta tcggggtcaa 1911421 ggatcggctt ttgcagcttc tgtttaagtc gctttctctc cagcaggctt tgcttatgtt 1911481 ccggcagaaa catcctgctc ccttcccaca gcaggttgcc cctttttaaa tggtcgttca 1911541 tttataatgc ccccctattt tagccgcacg ttcaaatgcc tggcctgccg ctgtcagtga 1911601 cgccgccctg atgattgctg tatcgccgaa tcgattttta atgccatcca tcacatagcc 1911661 taggctcatt ttctttgcat aatcctgaaa taaattgagc tgccatatgt catcagatga 1911721 gagctgagac agattgacac cgaggcggcg gacgggtttc ccgtcccaaa atgtaagaaa 1911781 cagccgtcgt acagcctcat atacatcctg cgtagaatta gtcggctctg ccagcttcac 1911841 ttgccggttg aagcccgtcg gccaatcaaa atcagcaccc cggcagctca ctgacactgt 1911901 ctgccccatg accccggcgt ttcggcttcg cctgcacacc tcttcactca gctcaagcaa 1911961 tacgaccttg atttctttgt caaagtgttc gtagtctctc gggagagtca ttccatgacc 1912021 tatcgccttt tgcccgtcca gagacgaagt tgacacaggg gaatagtcga ttccgtttgc 1912081 cgtcatccac agcacgtggc cgttaatgcc ccatttcttt tttaaaagat cgagcggaaa 1912141 agccgcgagc ccgccgatcg tgctgatgcc cattcgattt aaatgatgct tcatgcggct 1912201 cccgacgcca aacatgctgc ccaccgggag cggccacatt tcggttttca tattttcttt 1912261 cgttaaggta aaaataccgt tcttattctt tttggcaaaa ttgtcacacg caattttggc 1912321 cagcgctttg ttagggccga ttccgacccg tgcataaacg ccgatctccc gcatgattct 1912381 gccctgaatg cttttcgcga tctccatcgg cgtcccaaac agcttctggc tgcctgtaat 1912441 gtccatgaac tgttcatcga tggaatacgg ctccacaagg tctgtatact cctcgagaat 1912501 ggccgtaatt tgcagtgata catcaatata ccgctgcata cgcggccgga gcacaacagc 1912561 ctcaggacac ttttcctgcg cctcccacag ccgtgaagca ttcaccacac ccttttgttt 1912621 cgccagcggg caggcagcca atacgactcc gccccttttt tcagggtcac ccgaaacaat 1912681 gacgggccta tttttcaaat gtggattttc cgctttctct acagatgcat aaaacgattg 1912741 catgtcaacg agaaaaatca ctttttcttt catcatacac acctctaaaa agaacttatg 1912801 ttcgcttttc attatatgcg aaagtatgtt cgttttatac tggtaaatga ttcttgtctg 1912861 acagaaaata tgatccaagg gtttgagaga agaaaaacat ttagtagaat aaaagcgaag 1912921 cataaggata ggagagtcat gatggagaaa tttgtcgaaa aaatgctggg acaggcattg 1912981 cggcaatacg gcagaaacgt tgctatagat ccgttaagcc cgtatgaaaa acaaagcctg 1913041 aaagcggctc tacaagagag acggaatgaa gaaccagatg aggatttgca tgcgcatata 1913101 gaagatatca tttatgacta tgtcacaaac caaggcctgt tctcttaaac gcatgactgt 1913161 cagttctttc agccgctgat gcggcttccc tttgaaaaca ccgcctgaaa caaataaaca 1913221 gtctcaggct tacagaaaaa aagcaggatt ttctcacgct ccatagattc atatggcctg 1913281 gcgtaaaatt cccctcaatg ctcgcgcaaa acggaataag ctgtccatga tcacgcgtat 1913341 acactttttc gaagagatgt gctctcttgt tctgtcatgc ggtccatgcc ggttttcagc 1913401 gtacatcttg atctcatagc cggtttcact gccgatatga tccacgttct ggcggcttaa 1913461 actaacacac cctcactgac caatcgcttt gcttttcatc ggacatcccg tcattttcct 1913521 tctttcaaga tgtaaactcc gtcagccaca cgcatcctca acgcatagta tattgccatc 1913581 catacaatca ggcatactac atgtcaataa cgaaatattt tgaacgatct attggagaag 1913641 gaaatttttt catatatgat agagaaagat catacataca ggagagaata taattcatga 1913701 agaaatggaa agatatccac ccgatcagct ggacaattat aatcggaacc attttcggca 1913761 gaatggcaac atcgatgagc attccttttt tagcgattta tttgacagcc gtccaaggcg 1913821 catcagcttc ctatgcaggg ctggtcatcg ccgcgagctc atcagtcggc atcctcgcaa 1913881 gcttttacgg cggatatatc tcagataaat tcggcagaaa aaacatgatg cttgtatcga 1913941 ttttcggatg gatgctggta tttgcaggct ttgcggcagc atctaatctc tgggtgtttt 1914001 ttgtagtaaa cgcattaaac ggtctttgca aatcactgtt tgagcccgct tcaaaggcct 1914061 tgttgtctga tatgacagaa gaaaaaacga gactgctagt ttttaattta cgctatgcgg 1914121 ctattaatat cggcgttgtc ttcggacctg tgcttggcct atatttcggc tcatcgcaat 1914181 cgactacgcc ctttttggtg cctgcagtca tttacggact atacggaatt gtgcttgccc 1914241 tccaatttaa aaaacatcca tccttatcag caccagccca gtcccgaaat atgagcgtgc 1914301 gggaagcgtt tatggtcacg caaaaggatt atctttttac cattgctttg gtcggcatta 1914361 cgctatgcac cttcggctac tcacaattca gttccacatt ccctcagtat atggcgcaga 1914421 accccttgat cggcaatgga acgaagctgt atgggctgat gctgacatta aacgcaatcg 1914481 ttgtgttggc gacgcaattt cccattgtcc attttgcaaa acggttttcg ccgctttgtt 1914541 ctctgatgct cggtaatgtg atggttagca tcagcatggc cattttcacc gtatcacacg 1914601 gtgttccatc aattgtgatg attgtcatca catttacaat cggcgaagtg cttttattct 1914661 ctatgatgga tttgtatgta gaccagattg caaaaccagg attaaaaggc acttatttcg 1914721 gggcaatcgg tttttcacag ctcggaaacg tcatcggccc ttgggtcggg gggatatgta 1914781 tagacctgtt tggcgctggc cggccgattt atattttttc tgtcctgagc ggcattaccc 1914841 tgctcggcct gccattttta gcgttcgcct atcggcaaat gaaaatggag accacaaaac 1914901 accgttcccg tctggaaaag ccgctttaaa taaaaaacgg aagagaatga atctctcccg 1914961 caaacatgag gtgaagaaca tgaatatagg tgatgtgatg tttcagctgt ttgtatttat 1915021 tatatttgcc gctgtcgtct ttgcggctgt tacaggcttc aagtatgcga aaaaccgaaa 1915081 agcgcagctg gatcgcattg agaaaaagct gaacagcctg tccgaagatc acgattaaca 1915141 gcttggggca acgagctcta ccttaatccg gtctggatcc tcacaaaaga ctgcataatg 1915201 cccgtctcct ccggcaaaag gatgcctgtc tcggtacaac acacgatagc cttttgccgt 1915261 caatttttca gtcatctgat cgacttgaag cttggattca gcatgaaatg cgagatggtt 1915321 cagaccgact cggcatctat ggtattccgg ctctagaaat ggctctttcg cctgcacaat 1915381 cactaggtaa aaacgatctt tcttccagct gatgcctgag ctccattttt gatactcttt 1915441 ataaccaagt tcttttaaga accagcccca aaaccgccta gacgcctcca aatcagagac 1915501 atacagttca atatgatgca catttcatac cctccttacc aacacttcct cgaccttatg 1915561 cccgtctccc ttacgcaaaa tgagatctga cctgaattta gttggcaaaa tattttcata 1915621 taaattcggc cggttgacac tctcccaaat cgaggctgcc atctcgtcag cctcctgatc 1915681 ggacaagtct ttaaatttat gaaaatatga atcaggattt tgaaaagctg tttcccgaag 1915741 caggcgaaaa cgctctaaat accaagtgaa aatccggctt tcctccgcat ccacataaat 1915801 cgaaaaatca aagaaatcgg aaacaaaaat acgcgggttt tcccggtcat cctccaaggt 1915861 gggcgactga agaacattaa tgccttcaat aatcacaata tccgcctgtt ctacaacctc 1915921 gaacacacct tcctcgcggt cataggttag atgggaatac accggggcct ttacgctgtc 1915981 ctttcctgat tttaagtcat tcaaaaattc gagcagcgcc tttacatcat agctttcagg 1916041 aaatcctttt cttgacatca tatttttctt tttcagctcg gcagtaggaa ataaaaaacc 1916101 atctgtcgtg ataaggctca cttttggacg gtcaggcaaa cgcgaaagca gcttctgcaa 1916161 gatccgcgcc gtcgtgcttt ttccgactgc gacactgccg gcaatgccga taataaacgg 1916221 aattttggct gaatgtgggt gcttcaaaaa aacattgaca tgcttattgc gttcagccgc 1916281 agacttgaca tgtaaatgaa gcaagcgaac aagcggaata tagatcgtct ccacttcttc 1916341 aacagataga taatcattca atccttccac agcttttgcc tcttcttcag atacagcaat 1916401 cgacaaatgc cccccaaaac cagaccaaga ctcccgattg tgctgtgtat ataaagtatg 1916461 taggttaagt tctttatttt tcactgttta cacctgactc tctgtaggtt aaaaccctta 1916521 caaagattgt aacggaaaac cttttcactg tctgcttatt tttcatttcg tttttttagc 1916581 aaatcagcac cgattcggtt atacgcagcc atttcatctt ttggaaccat gcttcctccc 1916641 gttccccaga cgacatgtac ggcatgttcc atcttatatt tctgagcata gcgccttccc 1916701 tcttctgtcg aaaaaagctg aaccggcccg aacatgccag caagagcaga gggctctaaa 1916761 tatttatctt cagatacagc cagcatatga agcaaagtat aaagcgtatt gtcctctacc 1916821 gtataacagc cgctcagaag cggttcaatc agcttgccga caaatcctga cggcctccct 1916881 acggcaagtc cgtcagcagc cgtctgatta tccaggccga tatcctggac ggagatcttc 1916941 tcgtgaagtc ctgaataaag ccctaacagc atacaaggtg aatgagttgg ttctgcgaaa 1917001 aacacatgaa catcatctcc gtataaaagc ttcagcccaa atgctacacc gcccggtcct 1917061 ccgccgactc cgcacggcag atacacaaac aagggcgtct caagacttgg ctttatattc 1917121 atacagtcaa gctgtgtttt taatcggctt gcagcaacag catatcctaa gaacagctga 1917181 cgagaatgtt catcatcaat aaaataacag aatggatctt gttccgcctg ccgtctccct 1917241 tcgttcaccg cttcactgta atctgtttcg tactccataa cagtgactcc cttttggcgg 1917301 aggagatcct ttttccactg cttagcatcg gcggacatat gcactgtcac gcgaaacccg 1917361 agtgccgcgc cgatgatgcc gatgcttaaa cctagatttc ctgtcgaacc gacagcaatc 1917421 gaatagcggg agaaaaaccc ggtaaaccgc tcttcctgta agatgcggta atcatcggtt 1917481 tcctgaagca ttccttcttg aagcgcgaga ttttcagcat actttaacac ttcataaatc 1917541 ccgcccctcg ctttaatcga tcctgaaatc ggaagctcat ggtcgcactt taaaagccat 1917601 cttccgggaa atggctgctg atatgccgct tccagctttc ccttcatatg ctgcacctca 1917661 aaaagcggag actcgatgat tcctttagcg cctttcgtct caggaaacac ctcggcaatg 1917721 taaggtgcaa accgctgcat tcttttttcc gcttccgcta tctcggttgc ccactcatct 1917781 gcacggggta atggcccctc tttcttgcct gaatttgccc agaatacagg ctctgcatca 1917841 atcagtttct gaataaacgg atctttaagc agagcatgaa ggacttctga atgaactgac 1917901 attcaacaat ctctcccttc cactatcaaa aactgccccg tgagaaacaa gccactccac 1917961 cacaggcagt tctatcatta ttttttcatg agcgcgcgtc ctgccagctt ttctacaaga 1918021 gctggaaaca gctgatacag cttagtgccg gcattcatta aacgcggaag attgatctcc 1918081 cgctttttcg taaaaattgc agctgtaatt tgagctgcca cgtcatcagg atcaagcatc 1918141 cagcggccga catttttggc gtagtccccg cctttatcag caatggaaaa aaagtccgtc 1918201 tgaatcgggc ccgggttgac tgttgtcaca taaatgccgg ttcccgaaag ctccatccgc 1918261 aaagcgtttg agtaacctaa cacggcatgt ttggtcgcgg aatacaggct agacttcggt 1918321 gtggcgattt tccccgcttg agaggcgata ttgatgatat gtcccttttt ttgctcaagc 1918381 atttgcggaa gcaccgcttt tgtacaggcg atcaggccga agacattcac atcaaacatc 1918441 gctttcatgt catccaatgt agagtctaaa accgtttcaa atataccgaa gcctgcattg 1918501 ttaatcagta catcaatcga gccgatctga tcgcggaccc gggcgatatc ctctaggcgg 1918561 ccgacatcca gaggaaaaat ctcacactgt ccgctccatt cctcggttat tttccttttg 1918621 atttctatca aacgatcctc gcgtctagcc gacagcagga catgggctcc ttcagccgcg 1918681 cataagtatg cgattctttc tccaagccct cctgaagcgc cggttatcca aatccttttt 1918741 cccgctatat gtttcaccca tttcacctct tcattgtttt aaagtatacg gtatttcctt 1918801 cccaatatga cgtgatggct tcttcagcct ccaacacatc aaggtgacct gccgtttctg 1918861 acatcgttaa aaacaattcc ttttcatata cagcaggaaa aagctgctga cagacctgaa 1918921 aagcggtcat cggcttttca tccagcatgc gacgcacatc ctccgtcctg ttcctctgct 1918981 tgtcaaaacg cttctcaatc agcgcttgta cactggtgat aggctcgccg tgaccaggaa 1919041 atacgattgt tggatcaagt tgagacagcc ttcgcaatga ccgctgataa tccactaaag 1919101 gctttgacct gacgtctccc gctttcggcg cttccaaaat cggattagac gagctgtttg 1919161 ccagcagtag atcgccgcca agcatccttc cgcttttttc atggaacaga acaatatgcg 1919221 attcagcatg tccaggcatc tccaacacag accagccctc aagcccatct atgcccatac 1919281 cttctctgat tgattttgtc agagatctcg tacaggaaaa tgcgtacgct gatcgaatca 1919341 gcttttccgc cttccccgta tcaaatggaa cgcctaattc aggcagcagc ttttgaaaaa 1919401 aacgtttttg ccaatccata aaggcttgat tttggctgat ataaggttcg ttgaatgtat 1919461 gcccaatcac ttcgatttca tctgaaaaga catcaagcaa gcctgcatga tcagcatgat 1919521 ggtgagtcag tacaacctgc tcgatatctg acaatttcac atttacagcg gcaagctgct 1919581 cttgtaaggc tctggcagcc tcttttgtat tcggcccggc atcgataagt gtcagcgcat 1919641 caccttttac gaggtaaacg ataacatcgc cgacagcaaa cggtgtcggg acgcggatcg 1919701 caattacatc ttcagttgtc atcctttcgc tccttgtctt cattcattat tcatatttta 1919761 gctttttctc ggtcttgtgt cattattgca gaatgagaac aaaccttttt gaaaaagcta 1919821 ttgacattag cttgtccgcc attgcataat gaacaacaaa ctaaaacgag aaccattgga 1919881 acgctatgac gaggaatagt atacaaggca atggcctaag agagcgatac ccccggctga 1919941 aaggtgttgc ggcccgcttg tttgtagaac ctgccctcaa gtcgcggtta ggaaaaccta 1920001 aacgtttccc gcgttacggg gatttgagct gagcacaatt tgtgctaatg agggtggtac 1920061 cgcgaacctt ttcgtccttt acgtgatgaa aaggtttttt gttgttctaa tagaaggagg 1920121 atatcaatga aaaagatagg atttgtcggc gccgggtcaa tggcagaagc aatgatcaac 1920181 ggcattttgc aaagcggcat cacaaaacca gaacatatct atattacaaa tcgctcaaat 1920241 gacgagcgtc tgattgaatt aaaggaaacg tacagcgtgc gtccatgcag agataaaaat 1920301 gagtttttca ctcacaccga tatcattatc ctcgctttca aaccgaaaga cgcggcggaa 1920361 agcatcgaca gcatccggcc gtatatcaag gaccagcttg tcatttcagt acttgcaggc 1920421 cttaccatcg aaaccattca gcattatttt ggcagaaagc tcgcggtcat tcgcgtcatg 1920481 cctaatacat cagcggcaat cagaaaatca gcaaccggat tttccgtaag cacggaagca 1920541 agcaagaatg atattattgc cgcaaaagct ctattggaaa caatcggtga tgcaacactg 1920601 gttgaggagc ggcatcttga cgctgtcact gcaatcgcag gcagcggccc ggcctatgtg 1920661 tatcgttata ttgaggcgat ggaaaaagca gcacaaaaag taggattaga taaagaaacg 1920721 gcaaaagcac tcattttgca gacaatggca ggggcaacag atatgctcct ccaaagcggc 1920781 aaacagccgg aaaagctgcg taaagaaatc accagtcctg ggggcactac agaggcaggt 1920841 cttcgcgctt tacaggactc ccgctttgaa gaagcaatta ttcactgtat tgaagaaaca 1920901 gctaaacgga gcgcagaaat caaagaacag tttgccggtg ccgccttaga gagacattct 1920961 tagatgtaag gacaaaaaca gaaggcacag tgccttctgt tttttatttt tcccgcagca 1921021 gctggccggc agattctgat tgctttaata gcgcggagat cgtaaatgaa agcaaatcgg 1921081 gaagcacttc aaaggaataa ggcatataca atctttccgt ccatttatgc gggtctttac 1921141 cagccggacc gacatttaaa actgggacat ataaagcctg atttttaccg cttggcaatg 1921201 aataccctct gttaaagagc ggcatattgc ttgtgtatgc atcaacctcc tgtttttcca 1921261 gctgaagata actcaagtcc gaaagtccgg ggaagtactg aacctcccgt aatgcaatgc 1921321 cgtatcgctc agccgcataa tgctttatct gatctgctgt atttctgatc aattgatcat 1921381 cctttgaaga aacagctgga taaagcggcg gactataaaa cagaacgatg agcggcgcat 1921441 cctccttaca aagcgaagca agctcagaaa caattttcgt cgaaaaatcc ctgtctccaa 1921501 gctcccccct gttagcaaag gcataattta gagcccgctc tgtttccgag atccccgcac 1921561 gcttttttgc acgcgagacc agctcatcaa atgtcaaaac agtgacgtcc cgctcaatcg 1921621 gctgaaatgg ctcaaattgt tgaaaatcct gtgttttctt ccgaacgttc gacatgattt 1921681 cctccgccgc ctgttctgct gttttaagca gcatctgatg cagctcacta gctgagcgtt 1921741 tcattgacag cacattaaat aatgtgacgg ctgtatgcgg tgtctggact gaatatgcct 1921801 ctttcaagtc cttttgcatt aagtttaccg gcggcggagt gacctcgcca tcaacctttt 1921861 cgcaataatc agcattcagt tcaagcaaac ggttaatctc agataccatt aaatttgcgt 1921921 ttagacctga aaacggctct ccaacatgtg tctcaatccc cttgcagaaa aaacccgcaa 1921981 gcaccttgcc aatgcttcct gtataaaaat attgctgctg atcgccggga aatttttcaa 1922041 acatcggttc ggcattcagg caagcggtta atgtgatatc atgctttttc tccatctcct 1922101 tcaatgcagg aaccgcttca atcatgcctc ttgaattcac ttcctcgtcc ggaaccgtta 1922161 tcaacagcag attgccctca aaatgcccgt tcattgccct ctccagcatc gacagttgaa 1922221 tacaaagccc cgctttcata tccatcgtcc ctcttccgaa cagccagtct ccgctttcgg 1922281 catctcttct cacacgttcc gggagcagct cttttttctc taaaaaggag ctcaaaagct 1922341 cagcaggctt gcaagccata tgtttaaatt cgccgtaatc ttctatgtca acgacatcaa 1922401 aatgactcag cagaagcact gtctttttga cattcttctt tttgactaga gccgtaagaa 1922461 aagatctgcc atcgtccatc ggatgaagtg ttacatcatc agggtgcttt tgaaaatagg 1922521 gcttgtcctt caaaataaaa taaagatact ctgcaagcgc tacctcgccc tttgaaccgg 1922581 tgatgctttc gtattgcaca agagaagtta aaagtgccag caattcgtcc ttcgtctgcc 1922641 aattcattga ttccgcccct cctatgaata aaaatgcttc tatactgaaa aataaactga 1922701 tttctcgtct attatacaga aatgtttgac aaaagcggtt catttgagca gtttatatga 1922761 cgggaaagaa atgacttgat ataatcaatc tctaaaaacc ttacgggagg cgaaagaaat 1922821 ggccagaaaa ttatttacac ctattacaat taaagatatg acgttaaaaa accgcattgt 1922881 catgtcgcca atgtgcatgt attcttctca tgaaaaggac ggaaaattaa caccgttcca 1922941 catggcacat tacatatcgc gcgcaatcgg ccaggtcgga ctgattattg tagaggcgtc 1923001 agcggttaac cctcaaggac gaatcactga ccaagactta ggcatttgga gcgacgagca 1923061 tattgaaggc tttgcaaaac tgactgagca ggtcaaagaa caaggttcaa aaatcggcat 1923121 tcagcttgcc catgccggac gtaaagctga gcttgaagga gatatcttcg ctccatcggc 1923181 gattgcgttt gacgaacaat cagcaacacc tgtagaaatg tcagcagaaa aagtaaaaga 1923241 aacggtccag gagttcaagc aagcggctgc ccgcgcaaaa gaagccggct ttgatgtgat 1923301 tgaaattcat gcggcgcacg gatatttaat tcatgaattt ttgtctccgc tttccaacca 1923361 tcgaacagat gaatatggcg gctcacctga aaaccgctat cgtttcttga gagagatcat 1923421 tgatgaagtc aaacaagtat gggacggtcc tttatttgtc cgtgtatctg cttctgacta 1923481 cactgataaa ggcttagaca ttgccgatca catcggtttt gcaaaatgga tgaaggagca 1923541 gggtgttgac ttaattgact gcagctcagg cgcccttgtt cacgcagaca ttaacgtatt 1923601 ccctggctat caggtcagct tcgctgagaa aatccgtgaa caggcggaca tggctactgg 1923661 tgccgtcggc atgattacag acggttcaat ggctgaagaa attctgcaaa acggacgtgc 1923721 cgacctcatc tttatcggca gagagctttt gcgggatcca ttttttgcaa gaactgctgc 1923781 gaaacagctc aatacagaga ttccggcccc tgttcaatac gaaagaggct ggtaatgccc 1923841 ataagagata tcctgtagag gatatctctt tttttatttt tagagaaacg atcggctaag 1923901 gttctccgtc tccctagtag aaccaattag aggagatgac tccaatgaaa tcagcttgga 1923961 tggaaaagac atatacaatt gacggatgtg cgtttcatac acagcaccgg aaaggatcaa 1924021 gcggtgtaac gattgtcttt gaggccggct atggtacttc ttctgagacg tggaaaccat 1924081 taatggcgga cattgatgat gaatttggca ttttcacata tgatcgggca ggcataggaa 1924141 aaagcgggca aagcagagct aaacgaacag ctgatcaaca agtgaaagaa ttggagagtt 1924201 tgcttaaagc agctgatgta aaacctcctt atttggctgt ttcacactca tacggagctg 1924261 tcatcaccgg tttatgggcc tgcaaaaaca agcatgatat tatcggcatg gtccttcttg 1924321 acccagcttt aggcgattgc gccagcttta cctttatacc cgaagaaatg cacaaatcac 1924381 atacgagaaa gatgatgctt gagggcacac atgcagagtt ttcaaaaagt ctgcaggagc 1924441 tcaaaaagcg gcaagtccac ttaggaaaca tgcctcttct tgtgttgtca tcaggagaac 1924501 ggactgagaa attcgctgct gaacaggagt ggcaaaactt gcacagcagc atattgtctc 1924561 tatctaacca aagcggctgg attcaagcta aaaacagctc ccacaacatc catcatgatg 1924621 aacctcatat cgttcacttg gctatttatg acgtatggtg cgcagcgtgc cagcaggccg 1924681 ctcctcttta ccaggcagtc aattaacgta aaaaaagacc gggccgtaag ggattcccgg 1924741 tcttttatat tattttgttt cacggtgaag ggtatatttc tttaaacgcg gtgaatattt 1924801 tttcagctcc aaacggtctg gattggtgcg tttatttttt gttgtgatgt aatttcggtc 1924861 tcccgtttca gtgcaaagct aaagtaacat ttactctcat aattaacatc tccttataaa 1924921 acgtaatgat tacgttttat tatacaacgt catcacaaat tgtcaaataa gagctccgcc 1924981 ttcagcctcg cgggacgttt acctctaaga aatcatatgc cgccacgcta ttggggaaaa 1925041 cgtcaaccgc ttctttttga agctccaaag aagcatctcc ctgatatctt gcgctgatat 1925101 gggttaaaat gagctgcttc gctcttgctt ctttcgctgt tacagccgct tgttccgttg 1925161 tactgtgata ataatcataa gcaagtttac ggtcttcctt agcaaaggtt gcttcatgaa 1925221 caagcacatc acaatccctc gcaagctctt ttagtttgtc acttactctc gtatcaccgg 1925281 agaacacaac agatcttccc tttttaggag gctccagaaa atcattccca ttgatgattc 1925341 gtccgtcttc aagcgttacc gtttcgcctt ttttgatttt ctgatataca ggtccgggcg 1925401 ggatgttcat ttcttttaat acgtcagcct tcaaggaacc cggtacgtct ttttcctgca 1925461 cacggtaccc gaaggcttcc actccatgaa taacagatac cgctgtgaca ataaactgat 1925521 cgtcctcaaa cacgattcct tcttcaattt cctggatcgc aagcggatat gtcaaatggg 1925581 ttttcgtgac ggcaaggctt gtttcaataa acgccttgat ccctttaggt ccgtacactg 1925641 tcagctcgtc ctctccgcct tgaaaggaac ggctccccag aagccccgga agtccgtata 1925701 catgatcgcc gtgcatgtgt gtaataaaga ttttctctat tttacgaggt ttaatcgttg 1925761 tatgtaaaat ttgatgctgt gtggcttccc cgcagtcaaa aagccatacc gaacgccttt 1925821 cttcaagcaa ttttaatgcc accgacgtta catttctcgc cttggcgggg atgccggctc 1925881 ccgtccctaa aaaaagtaat tccacgtttc cttcctccta ctagaaccag atacctacaa 1925941 gaatacagga tcaagcggaa aatgtgaatc ttgcctctga aaagaacaat cctttcgtgc 1926001 tagaaacatt ttttcagcat tctgcttaaa aaagggctta aatgtttgct ttcgttgaat 1926061 tttagattta aaatgaagga aatatacggg gtgtactaaa ataaagcttc gaataaagtg 1926121 aggtactttt agtgaaaaca aaccaacaac caaaagcagt aattgtcata ttcggtgcaa 1926181 ctggagattt agcaaaacga aaattgtatc cgtctattca ccgtttatat caaaacggac 1926241 aaatcggaga agagtttgca gtggtaggag ttggaagaag accttggtct aatgaggatc 1926301 ttcgccaaac tgttaaaaca tccatttcct catctgcaga taagcatata gatgatttca 1926361 cgtctcattt ttactatcac ccgtttgacg tgacaaaccc tggttcttat caagagctaa 1926421 acgtattgct taaccagctg gaagatacat atcaaattcc taacaacaga atgttctact 1926481 tggcaatggc tcctgaattc ttcggaacga ttgcaaaaac attaaaatca gagggtgtaa 1926541 cagctacaac cggctggtcc cgccttgtca tcgaaaaacc gttcggccat gatctgccaa 1926601 gcgcacaggc attgaataaa gaaatccgcg aagcatttac ggaagatcaa atttacagaa 1926661 tcgaccatta tctaggcaaa caaatggttc agaacattga agtgattcga tttgccaatg 1926721 cgattttcga accgctttgg acaaaccgct acatttcaaa cattcaaatc acatctagcg 1926781 aatcactagg cgttgaagac cgcgcaagat attacgaaaa atcaggcgcc cttcgcgaca 1926841 tggtgcaaaa ccatattatg cagatggttg cccttcttgc aatggagccg cctatcaaat 1926901 tgaacacaga agaaatccgc agcgagaaag tgaaggtgct gagagcactg cgtcctattg 1926961 caaaagacga agtggatgaa tactttgtgc gcggacaata tcatgctggt gaaattgacg 1927021 gtgtaccggt tcctgcttat acagatgaag ataatgtcgc tcctgactcc aatacagaaa 1927081 cctttgttgc cggcaagctc ttgatcgaca acttcagatg ggctggtgtt ccattctaca 1927141 tcagaaccgg aaaacgaatg aaagaaaagt ccacaaaaat tgtcgttcaa tttaaggaca 1927201 ttccgatgaa cctgtactac ggtaatgaaa acaacatgaa tccgaacttg cttgtcattc 1927261 atattcagcc tgacgaaggc attacgcttt acttaaatgc taaaaagctt ggcggagcag 1927321 cacacgcaca gccaatcaaa ctcgattatt gcagcaattg caatgacgag ttgaacaccc 1927381 ctgaagcata tgaaaaacta attcacgact gtcttcttgg cgatgcaaca aactttgcac 1927441 actgggatga agttgccctt tcttggagct ttgtcgactc tatttctgaa acatgggcag 1927501 caaacaaaac cttatctcct aactacgaat caggctcaat gggaccgaaa gaatctgatg 1927561 atcttttggt gaaagacggc ttacactggt ggaacatata ataagaagaa aaaagccgaa 1927621 aatgtttaca agcattttcg gcttttttac gctgaacaaa ggtataacaa tctccttaat 1927681 aacaaaaccc ccaaagctta agagcttcgg gggtttctat tgattacttc atccattcag 1927741 tatggaagat gccttctttg tcagtacgct cataagtatg agcgccaaag tagtcgcgct 1927801 gtgcttggat taagtttgca ggcagtacgg ctgtgcggta gctgtcatag taggctaatg 1927861 cgcttgagaa tgatggcacc ggcacacctt gggcaactgc aagtgaaatc acttggcgaa 1927921 gcgctccttg atagctttct acaatattct tgaaatagct gtcaagaagc aggttgtcaa 1927981 gctcaggctc gcgatcgtaa gcttctttga tcttctgaag gaatgccgcg cgaatgatgc 1928041 aaccaccgcg gaagatcata gcgatttcac catatttcag atcccagttg tattcttcag 1928101 aagcagcttt catttgggca aatccttgcg cgtatgaaca gattttactc atgaacaacg 1928161 cttttctgac cgcttcaatc agctcttctt tattttctgt aacaggcttc acttctggtc 1928221 ctgaaagaag tccgctcgct tttacacgct cttccttcat agctgagata aagcgtgcga 1928281 atacagattc agtaataatc ggaagcggaa cgcctaagtc aagtgcgctt tggcttgtcc 1928341 attttcctgt tcctttttgg cctgctttat caagaatcac atcaacaagc ggtttgcctg 1928401 tttcttcgtc tttttttgtg aagatgtcag ccgtaatctc aatcaggtag ctatcaagct 1928461 cacctttatt ccattcagcg aaaacttcat gaagctcatc agcagaaagg cccagcacct 1928521 gtttcagaat gaaatatgat tcagagatca gctgcatatc tccgtattca attccgttgt 1928581 gcaccatttt tacgtaatgg ccggcgccgt ccggaccgat atatgtcgta caaggttctc 1928641 cgtcaacttt tgcagaaatg gcttcaagaa tcggttttac aagctcatgt gcttcttttt 1928701 gtccgccagg catgatagaa ggtcctttaa gcgctccttc ttctccgccg gaaacgcctg 1928761 ttccgataaa atgaatgccg ctttcagcga gttctttgtt acggcgctgt gtatctttat 1928821 agtatgtatt accgccgtca attaaaatat catccttctc tagatgagga agaagagatt 1928881 gaattgtcgc atctgttgca gttcccgctt taaccattaa taagattttg cgcggtgttt 1928941 ccaaggattg gacaaattct tcaatgctgt aagtgccaac aacatttttt ccttttgcct 1929001 cctgtaaaaa ctcctcagtt ttactgcttg atctgttgta aacagaaaca gaaaatcccc 1929061 ggctttcgat atttaaagcc agatttttac ccatgaccgc aagtccgata acgccgattt 1929121 gttgttttga catattctaa cgtcccttct gcaaacgttt aatcatttta aaatttaaat 1929181 taaaataaaa tgatatttat aataaagaaa ttaccataca ttcacccttt ttttcaagcg 1929241 attcagcttt tcttttcatc ttgaaaaaaa tctttattaa agcttgttcc ctttgttttg 1929301 ctctcctctt tttttaacgt tgcccctttt ctgatcagtt tggtaccgta ctttttattc 1929361 agcttttcca tcatctgctg aatgggctca tccttcgcat cttcattaaa gctgaacaaa 1929421 tcgagctgtt tataggcctg ctctttttct actaaatccg ttccggtaat gccaagcagc 1929481 ctgacaggat ttttattcca atgtttaaaa aagaggtgct ccgcttcttt caaaatgtca 1929541 tttttttgat caatcgggtt tctcagcgta gtgcttcttg tgatggttct ccaatccgca 1929601 tatctaatca taataaaaag cttcgaagcc atgacttcct tgcgctgtaa acggtcactc 1929661 acagaagcgg caagctttct aaaaacgcct aacagctctt cttcatcact ggaatcatgg 1929721 gaaagtgtcg atgagttgcc gacgctttta aattcgtaaa tgcgctccgg gtcaaccggc 1929781 gcatggtgaa tgccatttgc tttattttta aggcgcggac cgttgatgcc aagcaggcgc 1929841 ttcagcgagt gttcatcagc tgcagctagc tctccgattg tatggatgcc gagtcccttc 1929901 agtttttccg ctgtcttttt gccgactccg tgcatctctc caacaggaag cggccacagg 1929961 atatcgggca cttgcctctt tcttaagatc gtaattccaa gcggtttttt catatcagac 1930021 gccatcttag cgagaaattt attcggtgca atccctatgc ttgacgggag cagcagctct 1930081 ttttgcagcc tgctttggat ttcttttgcc gtctctagag cgcggctgct gtatggtgta 1930141 tcggtcatgt ccatatagcc ttcgtcgatg gagacaggct ccactaggtc agtatattca 1930201 cgaagaatgg taaacatcgc tcgtgaagag tttctatagc ggtcaaagtt cggcggaaga 1930261 acgatgagct caggacaatg gcgcttcgct tgccaaaccg gcatcgttgt tttgacgccg 1930321 cgcgctcttg cttcgtagct gcatgttacc acaatgccct ttcgctcctt tacgtttccg 1930381 gcaactgcga ccggctttcc ccggagagcc ggatcatatg ccatttcaac cgacgcataa 1930441 aagctattca tatcaatatg gaaaataatt cggctctttc ccggcataaa caaatctcct 1930501 tttcggtcat tagacaacag cttgtacata tagtaaaatg aagctattga atggatgtga 1930561 tgacaatgtt tgtggaatcg ataaatgacg ttttattctt agtcgatttt ttcacaatta 1930621 ttcttcctgc tctaacggca atcgggattg cattcctctt acgggagtgc cgtgcgggcg 1930681 agcaatggaa atcaaaacga acagatgaac atcagacggt ctttcacatt aaccgaacag 1930741 actttcttat tattatatat catcgcatta caacttggat acgtaaagtc ttccgcatga 1930801 attcgcctgt gaacgatgag gaagacgccg gttctcttct tttataaacc gcatttataa 1930861 aaaggaggag aacaaaattg ttaaaaacat atcaaaaact tttggctatg ggtatctttt 1930921 tgatcgtatt atgctcgggc aatgctgcat ttgcagcgac taatcaggtg ggaggcctca 1930981 gcaacgtagg ttttttccac gattatttaa tcgaaccgtt ttccgctctg cttaagggtg 1931041 ttgccgggct gtttcacgga gaatacggac tctctattat cctcgtaacc attattgtgc 1931101 gtatagttgt attgcctttg tttgtcaatc agttcaaaaa acagcgcatc ttccaagaga 1931161 aaatggccgt tattaaacct caggttgaca gtatccaggt taagttgaaa aagacgaagg 1931221 acccggaaaa gcaaaaagag ctgcaaatgg aaatgatgaa gctgtatcag gagcataata 1931281 tcaacccgct tgcgatgggc tgtcttccaa tgctgattca gtctccgatt atgattgggc 1931341 tttattacgc gattcgctca acacctgaaa ttgcgtcaca ctcgtttcta tggttcagtt 1931401 tagggcaatc tgatattctc atgtccctta gtgcagggat tatgtatttt gtccaagcct 1931461 atatcgctca aaaactgagc gcgaaatatt ccgctgtccc gcaaaaccct gcagcgcagc 1931521 aatccgcaaa attgatggtg ttcatcttcc ctgtgatgat gacgattttc tcgcttaatg 1931581 tgccggcagc ccttccgctg tactggttta caagcggact gtttttgaca gtgcaaaaca 1931641 tcgtccttca gatgacgcat cataaaagta aaaaaacagc cgctcttact gagtcggtga 1931701 aataaaaaag caaccccgtg caaaaagccg gggttgtttt ttgttacttg caaagtaccg 1931761 cgccaaacag tcttgtttat catggctgaa gcagaaatgg ccatcctaaa aaatagccgt 1931821 atcgtttaaa aagaaggaaa tcgggaatac ctttactcac ctccaaccga aaggagccta 1931881 tacgttgacg gaacgctttc agcaaaaaaa tatttctgta cctgatggaa tctggatcat 1931941 gagacaaacc tggaatgatg tcttatttgc tcactggcct gttgatgttt ctatccttcg 1932001 cgctttggta ccgtccgttt tagaattaga tacatataac gggcaagctt ggatcagcat 1932061 gcttcccttt atgctcacga acctgagggc gcgttatctc cctgtcattc ccggtgcgcg 1932121 tgcatttcct gagcttaacc tccgcaccta tgtcacgtat aaaggcaagc ccggcattta 1932181 tttttttagc ttagatgccg atcatcgtct ggcggtcctt ggcgctcgca cattctttca 1932241 tctgccttat ttttacgcgg atatgaagtc cgaaaaaaac ggtgatgcca ttgactatgt 1932301 cagcaagcgg aaaaatgaca aagaagcagc attccacgcc gcataccggc caatttcagc 1932361 gccttttaca gcagaaaagg attcgctcga ttactggctg acagaacgat acaggctcta 1932421 caccacttat cgcaataagc tctattacga agacatccat catcatccgt ggctgctgca 1932481 aaacgccgaa gcagaaattt cagtcaatac ggtgactgat gctcacggta ttacattgcc 1932541 ggagtcagac cccttgcttc attatgctaa aaaacaggat gtgttatttt ggccgcttag 1932601 gaaatggagc taaaaaaacc cgatgcggga aatcgcactc gggttttctt tttttatttt 1932661 gccgcctctt caataatggc aacaaccatt tctgccgttt taacgagctc ttcgatcggc 1932721 attttttcat tttttgtatg gatttgctca taaccgacag caagattgac cgtcgggatg 1932781 ccatgaccag cgattacgtt cgcgtcgctt ccgccgccgc tcgtttgcag ctcgcttgga 1932841 cgtccgattt tagcagccgc ttttttcgcg atttcaacaa cttggtcgcc gtcttgatat 1932901 ttaaagcccg gatacataac ctcaatttcg acttctgcgc gtccgcccat atcagcagct 1932961 gcctcttcaa aagcagcttt cattttttga acctgagctt ccattttctc aggaactaaa 1933021 gagcgcgctt cagcaagaat atgaacttcg tcgcacacaa tgtttgtttg tgtgccgcct 1933081 tcaaaccggc cgatattagc tgttgtttct tcatcgatac ggcccaatgg catttttgag 1933141 atggctttgc tagcgattgt aatcgctgaa atgccttttt caggttcaac cccggcgtga 1933201 gcggttttcc cgaaaattgc cgctcttacc ttcgcctgtg tcggcgcggc cacaatgata 1933261 tttccgactt ttccgtctga atcaagagca tagccgtagg atgcagtgat catagaacgg 1933321 tcaagcgcct tcgctccgat cagacccgat tcttccccta ctgtgatgat gaattcaatc 1933381 gtgccgtgtt caatattttc ttctttcagc accttaatcg cctcaaacat tgcagccaat 1933441 cccgctttat catcagcacc taaaatcgtc gtgccgtcag ttttgacgta accgttctct 1933501 acaactggtt ttacgccgtt tccgggtaca actgtgtcca tatgagatgt aaaatagatc 1933561 gtatctgttt gttttgtccc ttttagcgtg caaatcaggt taccggctcc gtggcccgtg 1933621 atatccattg tatcgtcttc tttaacgtcc acacctaaat cagaaaattt tcgtttcagc 1933681 actttgcaga tttcagcttc gtgctttgtt tctgagtcaa tttggacaag ctctaaaaat 1933741 tcttccagca ggcgtttttc attcaccatt tgtaagtccc tccatattaa agcggtatgt 1933801 taccgtgctt ttttttcggt ctctcttctg tcttatgtgt aagcatatga aaagcttgaa 1933861 tcagtcttcc ccttgattct tccggcaaaa tgatgtcatc gaccattcca caagcggccg 1933921 ctttgtatgg gccggcgttt tgctttttgt attcagcagt tttttcgcgt ttcgtctttt 1933981 gcgggtcagc tgaagctttg atttcctttt catacaaaat cgatgccgca ccttctggac 1934041 ccatcactgc gatttcagca ttcggccatg caaacacaag gtccgctccg atcgctttgc 1934101 tgttcatggc cacataggcg ccgccgtacg cttttctaat gatgagtgtg acttttggga 1934161 cagtcgcttc agcataagca aacaataatt ttgctccatg cctgatgatt ccgttgtgct 1934221 cttgctgaat acccggcaga aaccccggga catcttcgac agtcaacagc gggatatcaa 1934281 atgcgtcaca aaaacggatg aaccttgctg ctttatcagc agcgtcaatc gtcaggcttc 1934341 ccgccagatg cttcggctgg ctcgccacga tgccgattgc tttttcaccc agccttgcaa 1934401 acccaatgac aatgttcttc gcaaaaaatg gctgaatctc aaaaaaagac tgcgggtcag 1934461 ccagctccct aatcaccttc cgaacatcat aaggctttgt cgtatcagca gggacaagac 1934521 ggtttaataa cggtctggac gcctctttct ctggcttcgg ctctgttgtc cggccattca 1934581 gcggcaaata agacagtagt tttctcaccc ctgtcagaac ctccttctcc gtatgcccgg 1934641 aaaagtgggc gtttccgctg acggcattat gtatccccgc tccgcctaag ctctccgcat 1934701 caacctgttc ccctgtcact ttttcaatca ccttcgggcc ggtaataaac atccggccag 1934761 tctgttcagc cataaatata aaatctgtga gtgccggaga atatacagcg cctccagcgc 1934821 acggccctaa aataaccgat atttgcggaa tgactccgga atataagacg tttcggtaaa 1934881 atatgtgacc gtatccatct aatgataaca caccctcttg aattctcgca ccacctgagt 1934941 cattcagccc gataatcggc gccttatttt ttgctgccag atccatcaaa gcgcagattt 1935001 tcctggcatg ggtttcgcca agcgcccctc cgtacactgt gaagtcttgc gcaaatacat 1935061 aaactgagcg accgtcaatt gtgccgtacc ctgtcacgac cccatcccct aacatgcgct 1935121 gttctcttgt taacacttga ctttccatga aggggtgtaa ttcgataaag ctgtcctgat 1935181 ctagaagaaa tatgatcctt tcccgagcag tgagcttgcc cttttgccgc tgctgagcca 1935241 gcttttcccg tcctccgcct tcttctgcct gcttgcgttt cgtgtaaaaa tgatccatgt 1935301 gctcattcat gctcattgtg ttggtctcct ttcggttcac aaagctctac aagaacaccg 1935361 tttgtttccc gaggggaaat aaacgcgatc tttttcccgt tcgctccctg tcttggaaac 1935421 ctgtcaatca attgaacatg ctgatcagac aatgcttgaa gctgttcaga taggcagttg 1935481 cacaaaaacg caatatgatg cagtccctgc cctttcttct ccaaaaataa atggacgggg 1935541 ctgtcagctg tcaacggctc tatcagctca agtttgacgc taccagcttg aaaaaaagca 1935601 acattcacct tttgctcttc aaccgtttct tgatgaagaa atgcaagccc caatacattt 1935661 tcataaaagc ttcttgcatc ttttatcgaa aaaacggcta tcccgatatg gtcaagcctg 1935721 ttcattttca tccctgcttt cgctaataga tatcgcttgt ccgcccattc aaaacacgct 1935781 aaaatataga cagattgttt aaggagtgaa aatcatgtct caaaaactga tgaaaagcgt 1935841 tttgatcgtg attttgggag tttttattct ttcaactgta ctctcaggaa tcgtcatgtt 1935901 tctataacga taaaaaagca ggcgccttat tcaatgggaa tatcctgctt ttttatcaga 1935961 gctttatgct cgatggcaat ctcctcaaaa gagcggttgt cgtccgtgat cagcactctc 1936021 gttcctactg gtatcgtttg aaacaaatga acaacctcat cgttatgcat acgtatacag 1936081 ccgttagaca caaattttcc tactgattcc tctcggtttg tcccatgaat tccataaatc 1936141 cgcccgtccg ttcctttcgc gtcaaatccg atccatcttg ccccaagcgg gttatcagga 1936201 gatccccctt caatattttt ctttctgtag taaggatttt ccgcttttac cgttaccgaa 1936261 aactctcctt caggcgtcaa atcatctgtt tttccagtcg ccacactata cacgccttct 1936321 actttgttgt cgaggataac agcaagttca tttgttcgct tgttgacaat aacatacgga 1936381 tcacccggca gcggattttc gccgagcggc caaatcggtg aaatcatcat gaaaatcgaa 1936441 cataagaaaa aacgcataag ctcctccttt ttcattaggt tgaccaatga aggaagagct 1936501 catgcgaatc atccgagtga tttttgcgct tttattcctt taaaataact tttaatcact 1936561 aaatattgtt ccatttcgcc gagaagatgg aagagagcgg ccctcgcttc aaattcctct 1936621 ctagtcgcag gaagcggcat ctcctcaaat tcttttctca tgtcagcaag tcttttcaga 1936681 aatttgtatg ctgtattccc agggtgtatc gcctcccgca aatcatgaat aaattcagcg 1936741 atcatttttc cctgatctac cgtgatggag atcgatgtca ctttagggag aaggcgttcg 1936801 ataatttcaa attgcttttc tctcatttta aaataatgat aatgcagatt ttcataacgc 1936861 aaaatgtggt tttgcacatc tcgatatgcc aggtttttag cctccgtaat gagctggtgc 1936921 gtttccggaa tttcttttcc tgaccaatct tgctcaccag ttaacaaata ccgttcgatt 1936981 tctgcaaaaa tgacagcaaa gttatcctct atctttttgc ggtaggcaat cagtttccgg 1937041 tcaagactag gcatatacaa gttcatcaat agagcgacgc cgatgccaac cgtaatcagc 1937101 tgaacttcat tccagatgaa agtaggcgta atgccgccgg acatgtataa atgaaggata 1937161 ataacagaac tggtgacgat accctcgtta atttttaaca gaaccgttat cggaatgaat 1937221 atcaaaagaa gcgctccgat cacaaacggg tggtagccaa taagctcgaa aaagagataa 1937281 gaaaaagcaa ttgccagaca gcatgccgaa aagcgggccc atgaggcctg aagcgaccgt 1937341 ttttgtgtga tttgtatgca caaaatggtg atgattcctg ctgatgcgaa gttttgcaaa 1937401 tgcaataact ggcttatata aatagccaaa gctgttccaa gcgcggtctt tattgtgcgg 1937461 taaccaattt taaacatgtc ggactccatt tctatttgtt tcttcaataa aaaagaagag 1937521 gcggccagcc ttcttctttt ttatattcta taatattttc tctaaaaagt cctgcgctct 1937581 tttggatttt ggcgacataa aaaattcctt cggattgccg tcttcgacaa tcattccttg 1937641 gtccataaac agcacacggt ctgccacttc ttttgcgaag cccatttcat gtgtgacaat 1937701 caccatggtc atgccggttt cgaccagctc tttcatcacc tgtagcactt ctttgaccat 1937761 ctctggatca agggcggagg tcggctcgtc aaacagcatg atgtccggat tcatcgcaag 1937821 agccctggca atcgcgacac gctgtttttg tccgccagac aaacggtttg gatagtcatt 1937881 tcgcttttca aacaaaccga ctttgcggag caggtcctca gctttctcct gtgcagcctg 1937941 ttttgattct ttttttacat tgacaggcgc gtacatgatg ttttcgagaa ccgttttgtg 1938001 cggaaagaga tgaaaatgct gaaaaaccat cccgatgttt tcccggacct ttaatgtgtt 1938061 ggttttcggc ttcgtaatct ctgtgtcttt tattgtaatg gttccgccgt taggcttttc 1938121 caacaggttt aaacagcgta agaacgttga tttgcctgag cctgaaggac cgatcacggc 1938181 aacaacctca ccctcagcga ttgttgttga aatgtttttt aatacttcgt gtttcccaaa 1938241 tgattttgac agcttttcaa ccttaatcat tggatttcag cttcctttct acagccttgc 1938301 cgataaacgt taaaatcagg acaagcacat aataaatcaa tcccgcgata atgagcggct 1938361 caaggtaatt gtaagtggcg gcgccagctt gatatgcgcg tctcatgaca tcaccaagcc 1938421 cgatgacggt gacgatcgcc gattcttttg ttaacgtaat taattcattc acaattgcag 1938481 gtgatatatt tttgaaggcc tgcggcagca gcagatcctt catcattttt ccatacggga 1938541 caccgagtgc aacagcagct tctttttgcc ctttatcaat ggcattgatt ccggctctga 1938601 taatttccga tacataagcg gcggaattca aagacaatgc gacaaccgca gcccaaaact 1938661 ggtcaatttg aaatccgagc agctgaggaa ggccaaaata gacaatcata agctgcagca 1938721 ctaaaggcgt gcctcggaac actgatgtat aaaaatcagc gatccagata aacgggcgga 1938781 atgtgctgat cttgcataag cttagcacaa taccgagtat aagtccgata atagcagata 1938841 caacaacaat ttttaatgta attgccaagc cttctaatat aaaaggaatt tgggggatcg 1938901 ttgctgaaaa atccaaattc atagcctttg tctccttttc ttacaggaaa aaagtttcct 1938961 attcaataaa aaggctcaac gaaaaagttg agccgctttt ttttacttct cgccagtgaa 1939021 ccattttttc ttcaatttct caagctctcc gttatcttcc atttccttga gcgctttatt 1939081 gaatttgtct gtcagttcac tgtcctttct gaaagcaatt gctgaaccgg cttcttccgc 1939141 tttcgcatca ggaatcacaa agccttgcag gtcatcattt gatttgaaat acccttctgc 1939201 aacaatgtct tcaataatcg cggcatcgaa gcggtcagat ttgatttcct gcaccaaatc 1939261 agaaattctg ttgcggtctt ctgttttaaa accatattcc ggagaaagct ctttcccctt 1939321 ctcttcctga atagagccaa gctgaacgcc aactgttttt cctttcaggt ctttcaaaga 1939381 ttgaatgccg ctgtcttttt tgctgacaat catatggttc gctgtgtaat acacatcgga 1939441 aaaatcaact tgttttttac gctcaggcgt tggtgtcatt cctgacagaa cgagatccac 1939501 ctgttttgat ttaagcgctg taattaagct gttgaagtcc atatcctgca cttcaatttc 1939561 atagcctgcc ttctttgcca gagcttttgc cagctctaca tcaaagccga caatattatc 1939621 tccttcttta tattcaaacg gtttgtaatc cgccgaagta cccataatta attttttctt 1939681 tccgctttct gaacctgaat tgcttgagcc gcacgcagtt aatgcaaagg tgatgcaagc 1939741 agccacaagt aataagagcc attttttcat gatccatttc ccccgtattc attacttttg 1939801 gtgtatttga atatttattc gttaatttgt attttaaaca gtttctcatt tttatgcaat 1939861 actattttta aaaattatct ttaggcttat ctttccagtg atctcttctg atattactag 1939921 ataaaaatta aatcgctgta caatccgatt gaataatccc ttaatattta ttcatatatc 1939981 cttggaaatt tatgcacaaa aaaacccggg ctgctttgag catccgggtt gttcgtctta 1940041 tacttcttca caatattctt caaaggcttc ctgcagcttt gccactacag ccatcggctc 1940101 atggccttca atttcatgac gctctaccat tttcatgatc tttccgtctt tcaaaatcgc 1940161 aaaggacgga gaagatggtg gataaccttc aaaatagtca cgcgcacgcg ctgtcgcttc 1940221 tttatcctgt ccggcaaaaa cggtgacgag ctgatcaggt cttttatcat agtgaacgga 1940281 atggtaggct gccggtcttg caattcctcc ggcgcatccg caaacagagt ttaccatgac 1940341 gagcgtcgtt ccttttttcg taagtgcctc atccacctct tcggctgttt taagctcggt 1940401 gtatccggca gctgttattt cttgtctcgc ttggcggaca atatcattca taaataaatt 1940461 aaagtccatg ttcaatgaag acctctcctt tttcatcatc tgttcttatg atagcaagga 1940521 aacgtccata tcggcaaatg actttgcttc gccgtgcact ttttttgctc ttcgtttact 1940581 gcttacagaa aaaggggatt atataaccag aagtaaaata aaggagcagt tgtatatgag 1940641 ccaccggaaa gcgttactga ttcataacgg aaatgccggc aacaaaaata tagaaaaagc 1940701 acttggtgct gtggtgccgg ttttatctca ccatttagat gaggtgatta ttaaacagac 1940761 aaagaaaaag gatgatgcgt atcatttttg ccgatccatt gatgattctg tcgacaccgt 1940821 cttcattctc ggcggcgacg gcacgatcca tcaatgcata aatgctatca gcgctctaga 1940881 aagaaaaccc gctgtcggaa ttttgcccgg cggcacgtgc aacgactttt caagagtgct 1940941 tggcatccct caaaatcttg caaaggccgc ggaagcactt atggcgggaa aaaaaaccag 1941001 cgtagacgta tgtcagatga atgaccgtta ttttttgaat ttctggggga tcggcttaat 1941061 tgcagaaacg tcgaatcaaa tcaacgaaac ggaaaaagca ttattgggaa aaatcagcta 1941121 ttttacaagt gccttgcgaa ccgtctcatc tgctgcatcg tttccgatga cattaaaaat 1941181 tgatggagaa gaaattaaag aagaagccgt tatgctgctt gtgatgaatg gccaatacat 1941241 tggaacgaat cgaattcctc tgcccgatgc cagtattgaa gacggcttac ttgatgttct 1941301 catatgccgc aataccaacc tcaccgcgct gcgggagctg atgagcatgg aacaaggctc 1941361 aattgatcgt tttactggag agttgtccta tgtccaggct tcccgtatcg agattgaaac 1941421 agacactgcc aaaaaggcgg atatggatgg agaagtttat acacatacac ccgcagtcat 1941481 tcaggtcctg ccacagcata tcgacatgct tgttcccgca aatgaataac tgtcataagg 1941541 ctttagaaag attttgcaaa tccgttgact ctcccctagg aggaggtctt acagtataag 1941601 ggatacacac ttgaaaaagg ggaagtcata tggagaagaa aaatattacc ttaactatat 1941661 tattaaccaa tttatttatt gcttttttgg ggatcgggct tgtgattcca gtaacgccga 1941721 ccattatgaa tgaattgcat ttatcgggga ccgcggtcgg ctatatggtt gcctgcttcg 1941781 ctattacaca gctcattgtc tcaccaatag ccggacgatg ggttgatcgc ttcgggcgca 1941841 agatcatgat cgtaatcggc ctgttgttct ttagtgtgtc ggagtttttg ttcggcattg 1941901 gaaaaacagt tgagatgtta tttatctccc gtatgctggg cggtatcagc gcagccttca 1941961 ttatgcccgg ggtcacggct tttattgcag atatcacgac cattaaaaca cggccaaaag 1942021 cgctcggtta tatgtcagcc gctatttcaa caggatttat tatcggcccc ggcatcgggg 1942081 gatttttagc agaagtccat tcccggctgc cttttttctt tgcggcagct tttgcactgt 1942141 tagcagccat tttatcaatc ctcacgctgc gcgagccgga acgaaaccct gaaaatcagg 1942201 aaataaaagg acagaagaca ggctttaaac gaatttttgc ccccatgtat ttcatagctt 1942261 ttctcattat cttaatttcg tcttttggtt tagcatcatt tgaatcttta tttgcattat 1942321 tcgtggatca taaattcgga tttacggcca gcgacattgc cattatgatt acaggaggag 1942381 cgattgttgg cgccattacg caagtcgtct tattcgaccg cttcacaaga tggtttggcg 1942441 aaattcattt aattcggtac agcttaattc tctcgacgag tctggtattc ttgctgacaa 1942501 cggtacattc atatgttgcg attctgctgg tgacagtcac cgtatttgtc ggatttgatc 1942561 tcatgcggcc tgcggtaacg acttacctgt caaagattgc gggaaatgaa caggggtttg 1942621 ccggcggtat gaattcaatg tttacaagta tcggcaatgt attcgggcct attatcggcg 1942681 gaatgctgtt cgatatagat gtaaactatc ctttctactt tgcaacggtc accttagcca 1942741 tagggattgc actgaccatt gcttggaaag cgcctgcaca tcttaaagcc agcacgtgat 1942801 aagaagcgca ttctttgtgt actgcaaaga atgcgcttct tctttatact gatgatagaa 1942861 ggagtgatgg catgaaggaa tcgtattact caattgggga agtatcaaaa ctggcaaacg 1942921 tgtcgataaa agcgctccgt tattacgata aaattgattt atttaaacca gcctacgtcg 1942981 acccggatac cagctaccgc tattatacag attctcagct cattcatctg gatttgatca 1943041 aatcattgaa atatatcggc acacctttag aagagatgaa aaaagcacag gacttagaga 1943101 tggaagaact gtttgctttt tatacagagc aggagaggca aatcagggag aaattagact 1943161 ttttatcagc cctggagcaa accatttcat tggtgaaaaa gcggatgaaa cggcagatgg 1943221 aatatcccgc gctcggtgag gtgtttgttt tagatgaaga agaaatacgg atcattcaga 1943281 cagaggcaga aggaatcggg cctgaaaacg tgctcaacgc ctcctacagc aaattaaaaa 1943341 aatttatcga gtcagcagat ggatttacga acaatagcta cggcgctact ttctcttttc 1943401 agccctacac cagcattgat gaaatgactt accgtcatat tttcacacct gtattgacga 1943461 ataaacagat ttcatcaatt acgccggata tggaaatcac aacgatccct aaagggaggt 1943521 atgcgtgtat cgcgtataat ttttcgcctg aacattattt tctcaactta cagaagctta 1943581 tcaaatatat cgcggaccgc caattaacag ttgtcagtga tgtatacgag ttaatcatac 1943641 cgattcatta ctccccgaaa aaacaagaag aatatcgagt cgaaatgaaa atacggatcg 1943701 ctgaataata aagcatagaa aaagagcatt ttttgaaaca aaacttcaaa aaatgctctt 1943761 tttgcttatt tagtaaacag atgtcttctc gtcaatcgat tctaaaattt gtttcactcg 1943821 tccgaggaat cgtccgcaca cgagaccgtc aagcactctg tgatctaatg acaggcacag 1943881 attaaccatg tctctgacag caatcatgcc attgtccatg acaaccgggc gtttgacgat 1943941 ggattctact tgaagaatcg cagcctgagg gtagttgata atgcccatcg actgaacaga 1944001 cccgaacgaa cctgtgttgt tgacggtaaa cgtgcctccc tgcatgtcat ctgcagtgag 1944061 ttttccgtct cttacttttt tagctaggcc ggtaatgtct ttcgcaatgc ctttaattgt 1944121 tttttcatca gcgtttttaa tcaccggaac aaataaagaa tcctctgtgg caactgcaat 1944181 tgaaatattg atatcctttt tctgaataat tttgtccccc gcccacatgc tattcatttg 1944241 cgggaattct tttaacgcct gagcgaccgc ttttacaaaa aaggcgaaga acgttaaatt 1944301 aaagccttct gtcttcttaa aagaatcttt tatactgttg cgatatgcaa ccatatttgt 1944361 gacgtcgact tccatcatcg tccaagcatg cggaatttct gttttgcttc gcttcatatt 1944421 ggaagcaatt gcttttctta cacctgtgac agggatttct ttatcaccgg ctgcagacgc 1944481 aggatatgac gtctcttctt ttggctcagg ttttgatgca gacttcggtg caggagctgc 1944541 tgttttcagc tcctcaggat tctgttcttg cacgccgcct gtttcaatta agcgctgaat 1944601 atcttttcgt gtgatgcgcc cgccggcacc agttcctgtc acttgatcga ggtcaatgcc 1944661 gtgctctccg gccaaacgga gaacagctgg cgagtagcgc tttttattgg gctgatcggc 1944721 tgctccagca ctttttgcaa cagggttctc agcggcttct gatgctgctg gctgttcttg 1944781 tttttgttca gccggattcg cgccttctgt ttcaattttg caaatcattt ctccgacttg 1944841 cagggtttgg ccttcttctc ccacaagctc tgttatcgta ccagtaaaag aagacggaac 1944901 ctctgcattt accttatctg tcatgacttc cgcgatcgga tcgtatttgt tcactttatc 1944961 accgggggcg acaagccatt tgctgatcgt cccctctgtt acgctttctc caagctgcgg 1945021 catcgtcatt tgttcaattg ccatgattgt atcctccctt acgtctttaa aactccgcta 1945081 attctctcat cgccgcttcc actttatcag ggttgaccat aaagtatttt tccattgtcg 1945141 gcgcataagg catagccgga atatcaggac ctgcaagccg tttgatcggc gcgtctaagt 1945201 cgaacagaca atgctcggat ataattgcgg ctacttcgct catgatgctg ccttcttttg 1945261 tatcttctgt gaccaaaaga acctttccag ttttggacgc agcttcgatg atggcttctt 1945321 tatcaagcgg gtaaactgtt cttaaatcca ccacatgcgc tgaaatgcca tctttttcga 1945381 gacgttctgc agcttgtaag gcgaagtgga cacacaggcc gtatgtgatc actgtgatgt 1945441 cgtcgccttc cctttttacg tccgccttgc cgattggcag gacataatca tcagccggaa 1945501 cctcgccctt tatcagacgg tatgcccgct tgtgctcaaa aaacagcacg gggtcttcgt 1945561 cacgaactgc ggcttttaag agccctttcg cgtcatatgg tgttgatggc atgacaattt 1945621 tcagtccggg ctggttggcg aaaattgctt cgactgattg agaatgatac agggctccgt 1945681 gcacgcctcc gccgtatggc gctctgacga caatcggaca gctccagtca ttgttgctgc 1945741 ggtagcggat tttagccgct tcagaaataa tttggttgac tgccggcata atgaaatcag 1945801 caaactgcat ttcagcaatc ggtctcattc cgtacattgc cgctccgata ccgactcctg 1945861 cgattgcaga ttcagcaagc ggcgtatcca taacgcgctc ttccccaaat tgttcataga 1945921 gtcccgctgt cgctttaaac acaccgcctt ttcttcctac atcttcccca aggacgaaaa 1945981 cgcgagaatc tcgttccatt tcttctttca tcgccaaatt gattgcatca atatatgaca 1946041 ttactgacat ttgttcttcc tccctacttc gcataaacat aatcaagcgc tgactcagga 1946101 gctgcatatg gggcgttctc cgcttcatcc gtcgcttcat ttacgattgc cataatttca 1946161 tccagcatgg tttgttctat ctcatcggac agcaggcctg tttcctttaa gtaagcttga 1946221 taagtaagca ggggatcact ttttttcgct tcctctactt cttcacggcc tctgtagctg 1946281 ctgtcatcgt catcactgga atgtggtgta aggcggtaag aaatcgtttc aattaatgtc 1946341 gggccttctc ctctgcgtgc cctttcgcgt gcttctttaa ccgcttgata aacttccagc 1946401 ggatcatttc cattcacagt tacgccaggc atcccatagc ctatggcacg gtcggaaatg 1946461 ttctcacatg cgacttgctt atcgtaaggc actgagattg cgtatttgtt gttttcacac 1946521 atgaaaataa ccggcagctt atggacagcg gcaaagtttg ccccttcatg gaaatcgcct 1946581 tggtttgaag acccttcccc gaatgtaaca aaggctgcga tatccttttt ctccatacgt 1946641 cccgcaagcg caataccgac tgcgtgcggc acttgcgttg taaccggaga tgatcccgtc 1946701 acaatgcggt ttttcttttg tccgaaatgt cccggcatct ggcggcctcc tgagttcgga 1946761 tctgctgctt ttgcaaaccc ggacatcatt aagtcctttg ctgtcatgcc aaacgcgagc 1946821 acgacaccca tgtctctgta gtacggcaat acataatcca tttcacggtc aagtgcgaaa 1946881 gccgctccta cctgtgctgc ttcctgtcct tgacaagaga ttacaaatgg aattttgcca 1946941 gaacggttta acagccacat tctttcatcg atttttcttg ctaacagcat ggttctatac 1947001 atatcaacgg cttcctgatc agtcagccct agtgcttgat gtcggtttgt actcattcaa 1947061 gcccctcctt tatgctttta aaaatgaatg gctttgccat ctgcggcaag cgcagcttct 1947121 ccaattgctt cagaaagcgt tggatgcggg tgaatcgttt gcccgacctc ccacggtgtt 1947181 gcgtccagca ctttggcaag acccgcttca gaaatcatgt cggtgacatg cgggccaatc 1947241 atatgaacgc cgagaatatc atctgtatct cggtcagcca cgattttgac aaaaccgtcg 1947301 ctttcaccgt atacaagcgc ttttccaatc gccataaatg ggaacttgcc gattttgaca 1947361 ttatgcccgt tcgcctttgc ttcgtcttcg gttaagccga cactggcagc ttcagggctt 1947421 gagtaaatgc acttcggcac aagcgtcgga tcaagcggat gcggattgag acctgcaaaa 1947481 tgctcaacag caataattcc ctcatgtgaa gcaacgtgag ctaactgcag gccaccgatt 1947541 acgtctccga ttgcataaat atgagattcc ttcgtttggc agctttcatt gactgaaatc 1947601 atgccatttt cagtaacaat atcggtgttc tctaggccga tgccttcgat atttgcctgt 1947661 ctgccgatgg aaacaagcat tttctcagca gaataggtaa cggtttctcc gtctttttcc 1947721 gcttgtatgc tgatatcgtc tgatgttttt gtcattgtgt caggcagcac ttttgcccct 1947781 gttatgaact ggatgccttt tttcttaaga agactttcca tttcttttga aatctctaga 1947841 tcttcagtcg gcaatatgcg atccgcgtat tcaataaccg ttaccttaac gccaaaatca 1947901 tgaagcatag acgcccattc gataccgata acccctccgc cgacaatgat gattgactgt 1947961 ggcagctcct ccatttggag cgcctcatct gaagtcagta cagacttacc gtccacttca 1948021 agacccggaa gcattctcgg tcttgatcct gttgcaatga tcacttgttt cgggatcagc 1948081 atgtcatttt cttcgccatt tccccgctca acagaaattg ttcccggcag cggagagaag 1948141 attgacggtc caaggatacg tccatatccg gtgtacacgt caatttttcc ttttttcatt 1948201 aaatgattta cacccgctgc aagcttatca acaacggctt gcttacgctg ctgcactttt 1948261 tcaaagttga gggacacgcc agccgtttcc actccgaatt gatcggcttc acgagctgtc 1948321 cggtatacct ctgcgcttct aagcagcgct ttactcggga tacagccttt atgcagacat 1948381 gttcccccga gtttttcctt ttccacaacg gctgttttta agccgagctg agcggctctg 1948441 atggccgcaa cataaccgcc ggtaccgccg cccagaatga ctacgtcata ctcagttgcc 1948501 atggtgactc actcctgtct gtctattcaa tacgatattg tttggattgc tcttcgccct 1948561 gcaatactct tagcgcccct tgggcaagag actgcagttc attttcaccc ggataaacta 1948621 aaacgtctga aatccaatct atgtatgatc tgatagcaga aacaaagctt tttccgtacg 1948681 caaggcctcc cgtcagcaca atcgcttcaa cttcgccttt taacgccgcg ctggctgccc 1948741 cgatttcctt tgctacctga tatgccatgg catcataaat gaagcgggct ttttcatcgc 1948801 ccccttgaat catctgttcc acttttactg catcatttgt accgagatag cctaaaagtc 1948861 cgccggtgcc aacaagcttt ttcatgattt cttcttttgt atattcccct gaaaaacata 1948921 gatcaacaag atctcccgca ggcactgttc ctgctcgttc aggactgaat ggtccctcgc 1948981 cgtgcaggcc gttattgaca tccaccactc gcccgcggtc atggacgcca attgtaatac 1949041 ctccgcccat atgggtaata atcattttca tgttctcata tcgtttgcca agggaggctg 1949101 ccgctttacg agcgacagct ttttggttta acgcatggaa aatgcttttc ctttcaattt 1949161 caggcatgcc tgaaactttc gcaagcactg acatttcgtc tacgacaaca gggtcgacga 1949221 tatacgaagg gatattcagg ccgtcagcga tttcccgcgc gataatgccg ccgagattag 1949281 aagcatgctg accggcgtag ccgcttttca aatcctcaat catctcatca ttcactacgt 1949341 aggtcccgcc ttcaattggc cggagaaggc cgcctcttgc gcagactgca tcaaactttg 1949401 aaatattgat tccctgttca tgaagcgttt cgagaatatg gtttttacga aattcatact 1949461 gatcaataat tcggtcaaat cgctgcagct cttctatgtt gtgtctcaat gttttttcaa 1949521 aaatgcttct ttcgttatga aaaacaccga ttttcgttga agttgagcct ggattaattg 1949581 tgagaatgcg tttttcgtca tgtagcactt tcataacctc cagatcaatt tcttaacgtc 1949641 tgcttaatac actgtggccg ttttgcaaaa actggcttct tgagcggcgc atgcgttcaa 1949701 tccgttcctc tgctaagcgg tcagccgcta aatatgcagg aatgccgtca cgctgagaaa 1949761 tctcaagtac acgctcgata ttgccgtaaa tgccttcaac ttttttcaat gcacgttctg 1949821 cattatagcc gtaaagctca tctgccacgt tgatgacacc gcccgcgtta atcacgtaat 1949881 ccggtgcata aacgatgccc atttcgtgaa tttgatcacc atggcgtgtc tcttttaatt 1949941 ggttgttagc cgcacctgcg atcactttcg ccttcagctg tttaatggtg tcgtcgttaa 1950001 tagtcgcacc aagggcacac ggcgcataaa tatcgcagtc ttgtgaataa atgtcatcag 1950061 gatctaccgc acgggcgcca aaatcttcaa ctgcacgctg tacagattgt ttgttgatat 1950121 ccgtaacgat taagtttgct ccttcttcat gcaggtggcg gcaaaggtta taggctacgt 1950181 tcccaacacc ctgtacagca atggtttttc cttcaagaga gtcggttccg aaagcagctt 1950241 tagctgctgc cttcattcct ctgtacaccc cgtacgctgt gactggggac ggatttccag 1950301 aagagccgaa agcaggagaa atccctgtga catagtctgt ctcatcatga atgatatcca 1950361 tatcctcgac cgttgtgccc acatcttcag ccgtgatgta tctgccattc agtccttgaa 1950421 tatagcggcc aaacgcgcgg aacatttcct catttttgtc tttgcgcgga tcgccgataa 1950481 tgactgtttt tccgccgcca aggtttaagc ctgccgccgc gttcttatag gtcatgcctc 1950541 ttgccaatct gagcgcatct tcaattgccg cttcttcatt ttcatatgtc cacattctcg 1950601 ttccgccaag cgccggacca agcgttgtat catgaatggc gataatcgct tttaatccag 1950661 attgttcatc ctggcagaat accaattgtt cgtaatcgta tttctccata tatttaaaaa 1950721 gttccatgtt cgttcctcct aatgtgtgta ttcttcagat gcgcatattg ccagcgcaat 1950781 ggaatacagt ttattttcag cagagtccgc tctgcttgtt aaagcaatcg gtgcttttgc 1950841 tcctgtaatg acagccgcca cgctggcctt ggcaaaataa atcagtgatt tatataaaat 1950901 attgccggcc tcaattgttg ggacgagaag gatatctgcg ttgcccgcta cgtctcccga 1950961 aatttttttc tgggccgcgg caatttgtga aactgcgtta tccaaagcaa gcggtccatc 1951021 aacaatgcag cctttgatct ggcccctttt gtacatttga gctagagcag ctgcattcac 1951081 ggtcgcttcc attttagggt tcaccgtttc gaccgctgca agggcagctg cttttggcat 1951141 attgttcccc actgcatggg ccacatgaac ggcattttgc aaaatctgcc ggagctcttc 1951201 cagcgaagga gcaatattca ttgccgaatc tgtcacaaac atcagccggt caaaatccgg 1951261 tatatcgaag acagccacgt gagaaaggac acttgctgac cgaagcccct cctgtctgtt 1951321 caataccgct ttaagcaaaa cagaagtcgg cacattgcct ttcattaaaa cgtccgctgt 1951381 tttatgatgc acagcacgaa ccgctaattt cgccgattcc tcaggagtat tggcatggac 1951441 gatttccact tgatgccctt gcatggatga tgtcagctcg ttcagttttt tgctgtcgcc 1951501 cgttaacaag aaacgggcgg ataggtgctc ggctgccagc tttacagccc ggatcacttc 1951561 ctcatcctca gcatgagcaa ccgcaatggt cttatttttg tgtatcgacg ctttgccgat 1951621 taaatctttc agcttcatct gttaccacct ttcttgtttc gactccgcct tttattatgc 1951681 aagttccatg ccagctctta agggtgctgt cataccaggt ataccgaaac attcgtgcag 1951741 atgtttgcgt ttattctgca aattattgca tgccttcatt tgcaaggcca tatttatcca 1951801 ttttgtaata taaattccga atgctgacac cgagagcttt tgctgttttt gtccggttaa 1951861 aatgatgctt ttcaagcgtt tgctggatca aatgcgcttc aaatttttct actgcgacag 1951921 acagcttttc gccttcaata tccggaaaat caaaacctgt tccctgatct gtgtcatttt 1951981 ctttttgctc aagttcgaat acaggcaagt gatctttttc aatccattcc atatgcggat 1952041 tcagaaaaat catggctcgt ccaaggacat tttcaagctc ccggacattc ccaggccaat 1952101 ggtaggcaga taaggcgcgc aaggcttgct gtgagagccc ttttacattc ctgccgtaat 1952161 cccggttgat cttttggata agtctgacgc tcaatgcttc aatgtcctcc aaccgctgcc 1952221 gcaaaggcgg gatggagatc ggatagcgat tgatccggta atacaggtct tcccggaatg 1952281 ttccgtccgc catcgccttt tcaatattta catttgtcgc cgcgatcact ctgacgttga 1952341 cagggatcgc tttcgtgccg cccactctga cgatttcctt ttcttgaagg acgcgtagca 1952401 atttggcctg catattttgt gtcagctcac cgatttcatc taagaaaata ctgccgttat 1952461 ttgcttcctc aaataaaccc tttttaccgc cgcgcttcgc tcctgaaaac gcaccatcct 1952521 catagccgaa caattctgat tcgagcaggt tttcagaaag ggctgcacaa ttcacgcgaa 1952581 taaatttatt gtatttccgg tcactttcgt tatggatggc atgggcgaac agttcttttc 1952641 ctgttcctga ttccccgcgc agcaagatgg ttgccggtgt tttcgcaccg agcttcgcct 1952701 gctcaagcgc aaccagcatt tgctcgcttt tgccgataat gtcgtcaaac gtgtatttcg 1952761 cttcaagcgt gcgaataatt tgtctggcgc gattaagctc cgctgtcagc attttaattt 1952821 cggaaacatc gtgaatcacg ccgacgctgc ctttcaaaat cccgtccaca atcaccggtg 1952881 ctacattaac gatcacttct ttttcattcg ggccgacctt cattctgaca ccgcggacag 1952941 gacgtcttgt ttcaagcacc tttaaatgca tgctttcgcc ttcggaaata tcagtgtttg 1953001 caggcttgcc gatgacttct ttttcagaaa gccccgtcat tttcgtatac gctttattga 1953061 ttagcaggcc gatgccgttt tcatcaacga cagaaatcgc ctcatcggag gattgaataa 1953121 ttgcctccag catcgtacgg acctgcttta agttggtcac ttcctctgcc agctcgaccg 1953181 catcagtgat atctttaaac acacaaagag ccccgagcag acgtccgcct tcatcaataa 1953241 tcggcagtct tgtggtcaca atttgcaaat gatcgcctaa cagctgcttc tggttgtatt 1953301 caggcactct tgtttttaaa atccgcggca tcttagtgct cggaatcact tcttttattg 1953361 ggcgcccaat gacttcctca cgtttttttc cgaccatttt ttcggccata tggttaaaga 1953421 gaatgatttc ttcattgata tcaataaaaa tcattccatc atgggtggaa ttaaaaattc 1953481 tgtcatattt ataggtttgc tcttttagca tttgaatcag gtgctgcttt tcttccatca 1953541 gctgaaaaac gatgtatgcc atttttcccg gcatgacaat ggtatcttca tgctttcttt 1953601 gaaggagctc gtcaaacacg gcttgatcgc cggtagtatg aatgacgata tccggttttt 1953661 gttgtatgta aggtttccaa tcagatgata cggcaatccc atactgttct gcttctttca 1953721 atcccggcgc ctcggggtct ttgtcaacta cggcaatgat atctatgatg gctgttttaa 1953781 tcagaatatg taataacgcc gttccccttt tgccggcacc tactatcagt accttttgca 1953841 tcccgatacc cctttgtatg aaaaaatttg cacacctatt tattccgttg caataatttg 1953901 cacaacccta tgttaccacg ttttcttctc ttgacaaaat attttttccg ctggacaata 1953961 aaggaaatga aaagataaag gggttttctg aagatgagcc gacttcttgc gcttttaata 1954021 ttagtcatcc ccggggctat ttctgcttta ggcattaaac tgatgagaga tacacttttc 1954081 ggccatacaa tcaagccatt ttcagctctt tggctccaag ggttgtcagg attcatcttt 1954141 tttgcgatcg gcctctatgt gctggccggg ttcattttat acagagacag aaaacgcaat 1954201 caagtcagcc cgcgattcag aaaacgatag ctgaaaaaaa gccggagaat gctccggctt 1954261 tttttgttgc attattcgtc aggcaaaacg gtcttggcaa tcgttttgtc taacgcttca 1954321 tagtcataat aagaaatcgt atcgtacagt tcttttcgtg tctgcatatc atgaagtcct 1954381 tctttttgtg agccgtgctc cttcatcaaa ccaaacatcc gctcacaagc ttttgccgcc 1954441 gctcgaagcg aggtgacagg atatatcacc atgtgaaacc ccatatcttc gaattcatcg 1954501 gcacgataat atggcgtttt cccaaattca gtcatattcg caaggagcgg aacggggata 1954561 cgctcagcaa actggcggaa ttcattctcc gcctgtagcg cttccgggaa aattgcgtcc 1954621 gctcccgcct caatgtaagc ctctgaacgt tttattgcgg catcaagccc ttcctgcgcc 1954681 ctggcatcag tacgggcaac aacaataagg gagggtgccg cttgtttaat ggcttttatt 1954741 ttttgcgcca tttcctttat cggaactagc tgtttgccat ttaaatgtcc gcattttttt 1954801 gggagctgct ggtcttccat ttgaacggct gctaccctgg cttcaagcat ctcccgggct 1954861 gttcgggcgg catttaagac accgccaaat cccgtatcga tatccacaag caaaggcaga 1954921 tcagctgcac gcacaagatc tttggcccgt tcagctatct ctgccgatgt gatgatccct 1954981 aaatcaggca gccccctgct ggctgtatag gcagcaccgg acaaataaat agcagaaaaa 1955041 ccggcttctt tcgcaagcaa agcggccatc ccgtcatggg cgccgggaat ttgaagaatg 1955101 tccggtgctg acatcagctt gcggaaacgc ccggcaagct cctcttgtga cgattgctta 1955161 ttgacgatcc acgacatgaa acaaaatccc ccttttacat gcagaacatg tctacgaatt 1955221 catttacgcg catcgtttgt aatgtctcat agctggtaca gcgctcataa atgtgtttgt 1955281 gctgtttatc aggaaaatgg gttttgagat tgtcagaaaa cttttccagc agtttcggca 1955341 ctgcttcctc tcttcgaaaa cgatggccga ggggaaactc acattccacc atttccgtgc 1955401 tcgttccatc tttaaaatga acctgaacgg catttgagat ggagcgttta tcaggcttca 1955461 aataatcctc ggtatatgtt ttattttcag tcacttccat tttatcacga agtttatcta 1955521 ttctcggatc attcgctgtt tcagcttcat aatgctgtgc ggtgatatca ccaaaaagca 1955581 aaccgattgc tgtaatgtat tggaggcagt gatcacggtc tgccggattg tggagcgggc 1955641 cttttttatc aatgattcgg atagctgatt catgcgttct gatgacaact cggtcaatct 1955701 cgtcaatccg gttctttacc tgcgggtgaa gaatgacggc ggactccgcc gctgtctggg 1955761 cgtgaaattc cgcaggataa gacactttaa ataacacatt ttccatgaca taagcgtcga 1955821 gcggacgggc aagcttgatc tctttcttat tgaataaaac gtcttggaac ccccaacccg 1955881 gtgcactcaa ggctgtcgga taacccattt ccccttttaa cgacatcagc gccaaatgaa 1955941 cacctctgct cgttgcatct cctgccgccc atgatttacg cgagcctgta ttcggtgaat 1956001 ggcggtatgt cctcaatgct gcattgtcaa tccatgcatt cgaaagcgca tttttgattt 1956061 cttctcttcc gccgcccaaa agctttgctg caacagcagt tgtcgcaact ttgacaaaca 1956121 gcacatggtc aaggccaact cgatttaagc tgttttctaa cgccagcaca ccttggatct 1956181 cgtgtgcttt gatcatcatc tcaagtacgt cgcgtaccgt taacggctct tttccttcag 1956241 acagcctcac tcttgataca taatcagcag cggcaaggat tcctcccaag ttatcggatg 1956301 gatgccccca ctccgccgcc agccacgtat cgttgtaatc gagccagcga atcatgcagc 1956361 caatattaaa cgctgccctc acaggatcga gaacatatga cgttcccggc actttgcttc 1956421 cattcggcac agtcgttcct ggaacaatcg ggccaagcag ctttgtgcat tccggatacc 1956481 gtagcgccaa gattccgcag cccagggtat ccagcaatac atgccccgct gttgtatacg 1956541 cttcggcact agtaatctct ttctcaagca catagtctgt gatttcttcg ataacacgat 1956601 ccgttttcgg cattctacca gctcctttca tgattttgtt tgatatcgcg ggcccatgta 1956661 actgacacgg ggacggaaga gccgattatt ggcatgctgt tcgatcacat gggcgcataa 1956721 accggacgtt ctcgcgctga aaaagatcgg cgtatataaa ggaatcggta tgccgagcat 1956781 ccaatacact ggggcagcat agtaatccaa attcgggtaa agcccttttt ccttctccat 1956841 cagccgctca cccgcttcgc acatctcata taaacgatgg tcaccggctt tatcgcataa 1956901 ttgctgcagc gcctctttca tcatgagtgc tctcgggtcc atttttttca tatacacccg 1956961 gtggccgaag cccatgattt tttcttttct tttcagtttt gtttgcaaaa gctgctcaaa 1957021 atcagatgtc gtttttgcct ccaaaagcaa atacatcaca gcttcgtttg ctcctccgtg 1957081 aagattccct ttcagggaag cgacagcccc agtcaaagcc ccataaagat ctgaatgtgt 1957141 agatgcaatg accctggccg caaaggttga attcggcatc tcatgctcac tgtacaggac 1957201 gagcgaccgg tcaaaaatct gttcttccaa tgaagacggc aatttccctg tcatcatgta 1957261 gagaaaattc gcactgtagg atagggtttg aagcggaaga atcggttctt tcttattaat 1957321 gatcctgtag ctggcagcag tgagggcagg cattttccca agaagctgat aggcgcgttc 1957381 tttgtttgcg gaaggagacc gatcatcaat ttgccgatca tagccagcaa gtgccgacag 1957441 gccggtacgc agaccatcca ttggatgagt gtcctcaggg agcagctcaa gcagacggag 1957501 atgatcagca ggcaggcttg aggcactgtt tattttacgt tccagcgttt ccatttcact 1957561 ttcttctggc agcctgccct ccagcaataa atggacaagc tccagatagc tttttgtttc 1957621 agaaagttct attaaatcat agcctcttat caaaatctgg ctggactgcg tgtcaagata 1957681 agaaatatga gtttctgccg caatcacacc gtccaaccct ggagaataat gctgtttctc 1957741 ctccatatcc tcaacctccg tttttgcgtt ttttgtctat caggttccgc caagcaaata 1957801 cttggaaata atcagtcttt gaatctcgtt cgtcccttca taaatttgcg tcacctttgc 1957861 atcgcgaagc aggcgctcaa ctggataatc cttcatatag ccatatcccc cataaatttg 1957921 aacggcgtct aacgccgcct ttacggctgc atcggaagca aattgtttag ccatagacgc 1957981 ttcttttcca cagtttaggc cgcggttatg aaggtctgca gcgtggtaga caagatgtct 1958041 tgccgcctca gctctagtcg ccatatcagc cagcttaaat gatatgcctt gattggctgc 1958101 aatcggcctt ccaaattgca ctcgctgctt cgcataatca acggcatgct caagagccgc 1958161 ctctgcaatt ccgagggcct gtgccgcaat gccgatccgg ccgacattta aattcgccat 1958221 ggcaatgtga aagccatccc cctctttgcc aagcaaattg gcttcaggca cttctgcatt 1958281 atcaaaaatc agttccgtag tattggagcc ataaagcccc agctttcttt ctttttttcc 1958341 aacggtaaaa ccgggtgtgt ttttttcaac aataaaagcc gaaatcccgt gcctgccttg 1958401 atctggagct gttaaagcaa atgtgatata gatatcagct gctccgccat tcgttatgaa 1958461 tattttcgat ccgtttaata ggtatttgcc gttctttttg attgctgttg tgcggaggct 1958521 cccggcatcc gaccccgagt gaggctccgt tagtgcaaat gcgcccaaat ggtctcctga 1958581 cgcgagattt ggtatatatt tcatcttctg ttcttcgttg ccgaaataca gaatcggatt 1958641 cgtgccgact gaggtatgaa cggagagaat cacgccgaca gccgcgctga ttctagaaat 1958701 ctcatgaatt gccaaaatat aagaaacaac gtccgctcca gcaccgccgt attgttccgg 1958761 caccggtatt cccatcagtc cgtgtttacc catttttttg atcagctgaa agggaaattc 1958821 gtccgttttc tccatgattt ccgcagcggg agcaatttct tttcgtgcaa aatcacgcac 1958881 catttttcgc atcatgactt gctcttgggt tacatgcaac tcggccaccc ccggatggaa 1958941 tagacttcag gaagtcttct cctcatagtc ataaaaaccg cgtccgctct ttttgccaag 1959001 ccagcctgct ttgacatact tgcggagcag cgggcaagga cggtatttgg aatcgccaag 1959061 gcctgagtga aggacttcca taattgataa acacgtatcc agtccgataa aatccgctaa 1959121 tgcaagcgga cccatcggat gattcatgcc cagcttcatc acttcatcta ttgcctccgg 1959181 cttcgccact ccctcataca cgcaatagat ggcttcatta atcattggaa gaagcacacg 1959241 gttggaaaca aacccaggaa aatcattgac ttctaccgct gttttcccca tcttttccgc 1959301 taatgccata acatctaagg ccgtttcttc tgatgtagcc aagcctcgaa tcacttctac 1959361 cagcttcatt acagggacgg gattcataaa atgcatgcca ataacccgtt gaggccggtt 1959421 tgttacagca gcgatttctg taataggcaa ggaagatgta ttgctggcca aaatcgtatg 1959481 aggcgggcaa atgcgatcaa gtgttttaaa catctcagtt tttgccgcca tgttttctgc 1959541 gatagcctca atcacaatgt ccgcatgctc tgcctcctca agtgtttgag aaatcgaaat 1959601 gcggttgatt acgctcttca cttccgtctc ggtccttttt cctttctcag catcacgggc 1959661 cagctgtttc ttcagccgtt tcaatcctgc ctccgcggcc tctggattca catcatacat 1959721 ccgcacataa aagcccgcgt cggcggctgt ttgagcaatt ccgctcccca tctgacctgc 1959781 gccagctacc atgatttgtt tgatttccat tcaaatcccc tttttcatca tgttttaatg 1959841 aacctgcact aagacggcgt ctccctgtgc tgccccgctg caaatagcgg caacgcccag 1959901 accccctccc cgtcgcttta attcataaac aagcgtcatg agaattctcg caccgctcgc 1959961 gccgatcggg tggccgagcg cgatcgcacc gccattcaca tttacttttt caagatcgaa 1960021 acctacgatt ttttcacatg tcaaaacaac tgaagcaaaa gcttcattta cttcaaacaa 1960081 gtcaatatct tggacagtta aaccattctt tttcaggagc ttgttaatag caaaccctgg 1960141 cgctgccgcc agctcgtgcg ctggcattcc cgtagttgaa aaaccaagaa ttgtagccag 1960201 aggccgtttg ccaagctcag cagctttttc ctcagacatc agcacgaacg cgccggctcc 1960261 gtcattgact ccaggagcat tgccggctgt gatagaaccg tcacttgcat aaatcggagc 1960321 aagttttgcg agctgatcca gacttgtgtc acggcgaatc gcttcatctt tatcaacaac 1960381 gtttggtttt ccttttcgac cgatccagtt gacgggaaca atttcatcct gaaacttccc 1960441 ttcatcggcg gccttagctg cccttgcatg acttctcaac gcccattcgt cctgctctct 1960501 tcgtgagatt gcatattcct tggcagctgt atttccgtga acagccatgt gcacctcgtc 1960561 aaatgcgcac gttaatccgt catacaccat taagtcccta agctcgccgt cccccatccg 1960621 tgctccccag cgcccggcgg gaacggcata cggaatattg ctcatgcttt ccatcccccc 1960681 cgcaacaagt atgtccgcat cctgcgcccg aatcatttga tcacataaag tgacagcgcg 1960741 aaggccggaa gcacagactt tattcagtgt ttctgacggc acactccaag gcattcccgc 1960801 cagacgggca gcttgacggg aaggtatctg ccctgagccg gcctggacaa ccatgcccat 1960861 gacgtttcct tctacatcat ctccagagac tccagcctgt tgcagcgcct ccttcatcac 1960921 aatgccccca agctcagcag ctttcacctc tttcaaaact ccgccgaatt tgccaaatgg 1960981 agttcttgca gcacttacaa tgactgtttt cctcatggtt tcacctcatt cagaagatag 1961041 acagcgctta caatttctag ttgtcttcta tgaatgtatg ctttgaaacg ggcatgaatg 1961101 aatgaaaaaa gaaggctgcg tcaaacagcc tccttctaac aactattcat ttttcagcaa 1961161 tgccgaagcc ttttctggaa agtcggtaaa catgccgtct gctcccgctt caatgagacg 1961221 cttcatatct tccggacgat tgactgtata cggccttacc ttaatcaaac cgttcctcat 1961281 tttcttcagt acttcatctg tgacccctgg gctgtttatc ttcgggtgat agccggaagc 1961341 cggaatagac gcgatatatc gatctgcctg ataaagcaca tctgaagtta atactgcccg 1961401 ttcgatatgc ggtgcaagcc gggcgcacag cgccaagctg tcatgattaa acgtggatag 1961461 gatgactctg tcctctacat taaatcgctt cactgcctcc agcacttttt cttccattcc 1961521 ctcatagcgg atcacgctgt tttttaattc aatgttgatg agaaaatcct tttttaccgc 1961581 ccacgagagc acatcttcta gcagcggcac ttttatatcg ctgtacgctt gatcgtgacc 1961641 agcggccgca ttcgcagtct ttacctcatc ataggctgta tccttcacga atcctttaag 1961701 tgatgtcgtg cgattaagtc tttcatcatg aattacaaca atgcgtccgt ctttcgtcag 1961761 ctgtacatca agctctatcc catccgctcc ggcttcaatt cctttttcaa atgcaagcat 1961821 tgtattttcg ggaaattgac ctgatgcccc ccggtgggca aaaatctttg tcatcgtttc 1961881 acctcaaacc ctaaagtttt ctccattata cttattttgt cggctccact ctaggattaa 1961941 ggctgtatca atctactgat cataataaga atcaatgcca ttgacaatcg catctgcggc 1962001 cttttgctgg tattcttcac ttcccagctt gtccgcgtca gagctgttcg tgataaaccc 1962061 aagctccgcc aacacacttg gcatttgtga atatgtaatg acgtaaaagt ctgattcttt 1962121 cacgcccctg tctctcgttt gtaaggaaga aacgagctgt gactgaatat cggatgccag 1962181 acgccggctg ttctcccctt cataatcaga ttgaaaatac gtttctgttc ctgaagctga 1962241 agcaacccct gaattcacat gaatgctgac aaaaaggtca gcctgattgg cacttgcctt 1962301 agccactctt tcctccaagg tcagaaaatg atcgtcagac cgggatgcaa caggattggc 1962361 tccctcctct tttagtttgt ctgtcacatg ctctgagaca gccaaattaa tatccttttc 1962421 aaagagcccg tttccgaccg ctccactgtc ttcaccgccg tgtccggcat caatatacac 1962481 tgttttccct tctatcggct ctgctgcctg tgcacaaggc gcgagcgtca aagccaatcc 1962541 gcacagcgcc aagctcctcc ataacattct caacttactc cctccggtca cgagttcttt 1962601 cgcagctgaa tatcttccag ctgtaaagtt ccattatcct tctttgtata tttcaccagg 1962661 acatgtgtct gatctggcag tgattcacat tcatcacgtt tatccttcgg aacttgtatc 1962721 atggtttctt ctccattaag agaaaccgca atcgtatgag gatcagccga gccaatgtat 1962781 tttccctctt cggtaaacct cggcactgag tcatccgcac ttgcaacact gcaccccgaa 1962841 agaaagagcg cagtaaacag caaaagaacc gtttgtttca catgaccacc tcttcctgat 1962901 gtttggcttt tatctttgac cagaatggag aatttgtaaa gacaacgcga atgcaggcga 1962961 gcaagttcca tgattttcaa aagggctata cgacccgatc atttcctgtt gttagaaaga 1963021 taacgagcag atttgtctat gaggatggct ctaattgagg cgccaattag aaaaaattag 1963081 cggaaagaag caacttttta ttcattttaa aaaatttgag aatagggtga gcaaatcgtt 1963141 tgacgggtgg gtcagccaag cgtaaccttt taaaggatat ttactttatt gaaagaagtt 1963201 aaagccatga aaaaattcgt tctgctgctg gcggcagctg tcatcacatg ctccatcggc 1963261 caccaaatca gtggcggcta caaaggcccc gaaaaagagc ggccaaaaca tcactctgca 1963321 ctcaagatat tcagtcggta aagcagatca attgcattaa tttttacata taggctagaa 1963381 tatgtgcgaa tccaaacgaa agaagatgat caaatgaatc ctaagtataa gccacttttt 1963441 gaaccattta cgtttaaaag cggcgttaca atcaacaacc ggatcgcagt agcaccgatg 1963501 actcattacg cttctaatga agacggtaca atatctgaag cggagctcga ctacatcatc 1963561 ccccgttcaa aagagatggg aatggtgatt acagcctgcg caaatgttac accggacgga 1963621 aaagcattcc ccgggcagcc ggccatccat gacgattcca acattccagg tttaaaaaag 1963681 ttagcacaag ccattcaggc acaaggcgct aaagctgttg tacaaattca tcacggcggt 1963741 attgagtgcc cgtctgagct cgttcctcaa caggatgttg tggggccaag tgacgtgttt 1963801 gataacggca aacaaattgc tcgcgcatta acagaagaag aagtggaaaa cattgtgaag 1963861 gcgtttggag aagcgacaag acgcgccatt gaagccggct ttgacggtgt cgaaattcac 1963921 ggtgcaaacg gctacttaat tcagcagttt tattctccga aaaccaacca gcgcacggat 1963981 cgctggggag gaagcgatga aaaacgatta gccttcccgc tcgctattgt cgatgaagtg 1964041 aaaaaagccg cttcagaaca tgcgaagggt gcattcttag tcggctaccg cctgtctccg 1964101 gaagaacctg agacaccggg attgacaatg actgaaactt atacgcttgt tgatgcttta 1964161 ggggataaag aattggatta tcttcatatc tcactgatgg acgtgaactc aaaagcgcgc 1964221 cgcggtgcag atccgactcg cacacgcatg gacttattga atgaacgtgt cggaaacaaa 1964281 gtgccgctga tcgccgtcgg ttccatccat tccgctgatg acgcgcttgc cgtcatcgaa 1964341 aacggtattc cactggtcgc tatgggacgc gaaattctag ttgaccctaa ctggacggta 1964401 aaagtaaaag aaggccgtga aaagcaaatc gaaacagtga tcaaaggcac agataaagaa 1964461 aaatatcatt tgcctgaacc gctatggcaa gcaattgtga acacacaagg ctgggtgcct 1964521 tataaagatt aatgtgcaaa gactgccgaa acgattcggc agtctttttt ccctttatat 1964581 aaatagtttg tgtacacatc taaacagcaa aagaaagagc tccccaccaa cttcgaaaag 1964641 aaaatccagg aaaaacccct cacgctttct tgcttttttc tttttcattc gtacgtctcc 1964701 tttttacatg aatacgcctt acttacgatt ttgcaggaga aaggtttcat tttataacgg 1964761 acacatctag ggtcgatcat gcttcgtgat cctataagat gtatgaatgg accaagagtg 1964821 caggtaatac cgccatttgc tttccttact tttcaaacct atcctttact atatgcggat 1964881 acttaatatt cttctcccat actacaaatg tccccaaaac aaaacgcctc ctatttatca 1964941 gcgcaaacta ataaataaaa gacgtttgat ttaatgacca cttaataagc tcatgtttaa 1965001 gaagccttat gctctaacct cagcttatcc gcaaccattg caatgaattc actgttggta 1965061 ggtttagctt ttgtcatgct gacagtataa ccaaacaacg aggaaatgga atcaatgttt 1965121 cctctgctcc atgccacttc aattgcatgg cggatcgctc tttctacacg gcttgcggtt 1965181 gtgttaaatt ttttggcgat gtccggatag aggacttttg taatgctgcc gagcaattcg 1965241 atgtcattgt ataccattga gattgcttcg cgcagataga gatagccttt aatatgggct 1965301 gggacgccga tttcatggat aatgcttgtg atgctcgcgt cgagattttt cttctttggt 1965361 tcaggctggc tgctgcgtat aatactgctt tgcgatgatg gcgcacgatg cgtcacactg 1965421 ctggcatttc cgctgacctg gcggatatgg ccgacaaggt tttccatatc aaacggtttg 1965481 agaataaagt aggacgcgcc taaatcgacg gcctttttcg tgacatcttc ctgcccaaag 1965541 gctgtcagca taatgacatt cggctgtttt ttcagatctg attccctcag cctctctaaa 1965601 accgcaagtc cgtctagatg cggcataata atatctaata cgagcacatc gggatctttt 1965661 tctttaaaca gcgacaggca ttcctgtccg ttataagcaa cgccgatcac ttccatgtct 1965721 tcctgtcctt ctatatattc acttaacagg cttaccagct ctcgattatc atcagcaaca 1965781 caaactttaa ttttctccac gtttcttcct ccccaaatgt agttaacagg attcaccctt 1965841 gctacatgtt tacattcgac aaaaccgcta tataccctct aaaaaaatca taatcaccaa 1965901 tattagtggc atatctttgt tattctatgt ttttctctgt ttttcgacta aaaatgaaat 1965961 ttgacaaaca aggaaacgtg aatttgtcga aaaatcttct tttgtatatt ttaccgtatg 1966021 tattctgaga agtgaagagg gatcaggata tactgatgaa cgaatggatg tgcacgaaaa 1966081 aaataagctg cgcttctcgc gcagcttacc cagttgtttt gacttgatcc gcttgtttta 1966141 aaagttcttt cgcatggcgt ttcgttaagt cggttacttc gacacctgca atcatgcgcc 1966201 cgatttccgc taccttttcc tgcttagaga gcggcttgac acgtgtcgtc gttctgccgt 1966261 cttttaactc cttcgcaata taaagatgcg tatcggccat ggcagccacc tgaggcaggt 1966321 gtgtaatgca cagcacttgt gatcctattg acaccttatg gatcttctca gcaattgcct 1966381 gtgcgaccct gccgcttaca ccggtatcaa cctcgtcaaa aatgatcgat gtcacatcct 1966441 gttgtgagga aaaaatgctt tttatggcaa gcatcacccg tgacagctct ccacctgaag 1966501 cgactttcga aagggatttc agcggctcgc ctgtattggt tgaaattaaa aacttcacca 1966561 ggtcaatccc ttgttcagtc agctgaacgg gctggccgtt tacaagcggc gcctcttcat 1966621 tgcgtgacgc tgttctgacc ttaaattccg tatcaaaagt tgatttttcc atgtacaggc 1966681 tttttaattc ccgatgaatc tcatcagcca gctttttcgc ccatgttttt cggatttgtg 1966741 acacatttgc cgcttccact gcgacatctt tgccgacgga gtcaagctcc tttttcaagc 1966801 tttgaaggtg gctgtccctg ttttcaattt ggtcaatctc ttcttcaatt ttagaagcat 1966861 attccaaaat gtcttcaaca gtggcaccgt attttcgttt cagctgtttg atttcattaa 1966921 gtcgcgtctc aatatagttc aggcgttccg gatcaaattc aagctcatcc agcatatttc 1966981 tcatctgaaa tgtggcatcc tcaagcaaat agtaggagtt cgaaacactt tcagacattt 1967041 ttttcagcgg ttcgtttata tcagatatat cttcaagctg cgctgatgcc attccaaccc 1967101 agtccaatcc gccctgctca ctgcgaagcg cgttatatgc attttgcagc gactcatata 1967161 tcttctcaaa gtttgaaatt tgctggcgct cttcttggag ctgttcatct tcgttaagct 1967221 caagctttgc cgattcgatt tcttcgagct gaaattgaat aagatcaaga cgatgggcca 1967281 tttcctgttc gctttcagaa agctgcttaa gctttttgag cagcttcaca taccgctggt 1967341 acccttcctg atacgttttg agcgcgcttt ccacttcggc cccggcaaac ttgtccaaaa 1967401 gctggagatg attttcgtct tccattaaca gctggttatc gtgctgcccg tgaatatcta 1967461 ataaaagcct gccgatctct cttagtgaag caatcgtgac aagcttgcca ttgacacggc 1967521 aaacgctttt cccgctcgtg ctgatatccc ttctcatgac gatcatttcg tctgaaacgt 1967581 cgattccctg ctcagcgcat acgcctaaaa caggatggcc gctctccaac agaaacagcc 1967641 cttcaagttc ggcttttgct tccccatatc taacaaattc agatgatccg cggcctccga 1967701 ctaaaagaga aatggcatct atgatgatgg atttgccggc tccggtttct cctgttaaaa 1967761 ccgtaagccc gcgttcaaaa gaaaccgtca gttcctcaat aatggcaaag tttttaatcg 1967821 atagttcagc taacaaacag cattacacct cttatctttg ttagattttc tgttacagca 1967881 gttcaaggag cctgtttttt acgccttctg tatcttcagg agtccggcaa ataattaaaa 1967941 tcgtatcatc tccgcaaatg gtccccatca tttcatccca gtccaaattg tccatcagcg 1968001 ccccgattgc ctgggcattg cccggcatcg ttttcagcac aatcatatgg cttgctgagt 1968061 ctattttcac aaatgcgtcc atcaatgccc gctttagctt tgacagcgga ttgaaacgct 1968121 ggtccgccgg aagactgtat ttgtaagaac cattatttgt aggcactttt acaaggtgaa 1968181 gttctttaat atcccgtgat accgtggcct gcgttacttt gtatccatcc tgctttagca 1968241 tgtcgaccaa ttcatcctgc gtttcgattt cattgcttgt aatgatctct ctgattttaa 1968301 tatgcctctg gcctttgttc atgtaagcac ctctatttcc aagcttatct gttcttttat 1968361 gttatatgat tctctgcaca ttgtacatga atgcagaaaa aaggaataat agcgccctat 1968421 tattccggta catctgcttt tttttctttt aacgtcttat gtgcttcttc tacaacgcgc 1968481 atgatctctt cttccggcag ttcctggcct tcctgtccct ctcccggcca atgcaaatga 1968541 aggagaaact caatatttcc gtctcctccc gtgattggag aaaatgacaa gcctttacag 1968601 atatagcctt cagcggcaga aaaactgatc attcgcttga gcacatcagc atgcacttta 1968661 ggatctctaa caatcccttt tttgccgacg gattcccgtc ccgcttcaaa ctgaggctta 1968721 actaaagcca tgcagtcgct gcccggtacg agcaaagtcc ttaggacagg caggatgagc 1968781 cgcagtgaaa taaaggacac atcaattgtg gcaaactccg gcatgccctt tgtaaagtct 1968841 gccggtgttg cataacgaaa gttcgtccgt tccatcacga cgacccgttc atcctgtcta 1968901 agcttccatg caagctgatt atagcctaca tccacagcgt atgactgttt agctccattt 1968961 tgcaaagcgc agtccgtaaa accgccggtg gaggagccaa tatcaatcat aattttatct 1969021 ttgacagaga cgggaaattc cttcaacgct ttttcgagct ttaagccgcc cctgctcaca 1969081 tacctcagcg ggtttccttt gacagttaac ggaaggtcgc ggtcaatttt ttctccaggc 1969141 ttgtccaagc ggttttcgtt tgaatagacg atccccgcca taatggctct tttggctttt 1969201 tcacgcgttt ccgccagccc tctttccact aataatacat ctaatcgttc tttctttgac 1969261 gtcatgatcc aattcctttg tgtgtctttg gtggcatcag taatctaata cgatttgcca 1969321 cctgctgttt tgtcagtcca atttcctcaa gaagcgctgt tacacttccg tgttcaataa 1969381 accgatcagg tatacccatt ctgtcaatcg gagtatgata ttcaccttga tcatgagcga 1969441 attctaaaat cgagcttccg aaaccgcctt ctaagaccgc ttcttcaatt gttaaaattg 1969501 gcaagccttc ttttaggata ctcttcatca tcttttcatc aatcggctta ataaaacgcg 1969561 cattcacaac gcgcacggaa aggccttctt tctgcagctc ttcggctgct tcaatcgcca 1969621 tttcgattgt tgtgccgaat gttaagatga cagcatcgtt ccctggacgc agcacctccc 1969681 acgtaccgat cggaatcgtt ttcaactgtt catccatttt tacgccgagt ccgtttccgc 1969741 gcggaaaacg cattgctatc gggccttcgt catagctaag tgctgtatga accatgtgct 1969801 ggccttcatt ttcgtctttc ggcatcatta agaccatgtt tggaatgtgg cgcataaacg 1969861 caatatcaaa cacgccttga tgtgtctctc catcagcgcc aacgagtcca gcacggtcaa 1969921 ttccaataaa cacattagcg ttttggcggc agatgtcatg aacaacttgg tcatatgccc 1969981 tttgcaggaa ggttgagtaa atcgccaaaa acggcttcat accctgcatt gccatagctg 1970041 cagccattgt tgcggcatgc tgttctgcga ttcctacgtc gaacatccgg tcagggaatt 1970101 cctttgcgaa gccttcaagc tttgaaccga caggcatagc cggcgtaatg gctacaatgc 1970161 gtccgtcctc gcgcgccatt cgctgcacag ttccgctgac aagaccgctc cacgaaggag 1970221 ctgcggcttt cggctttaca aagtcaccgg tattaatttt atatggtccg gtaccatgcc 1970281 atgtcccaat cgtatcggtc tcagccggtt tgtacccctt cccttttttc gtaatgacgt 1970341 gcagaagaac agggcctttc gtttttttgg cgtattgaag attctcaatc agctcatgat 1970401 aagaatgtcc gtccactggg cccaaatacg taaaaccgag ctcctcgaaa aacattccgg 1970461 agacgagcat gtatttcagg ctgtctttga cccgttccgc cgtggcggca agcttgcccc 1970521 caactgccgg aatcttttta aataagtatt caagctcatc tttgacccac tggtatttcc 1970581 ccgcagtgcg gagccgtccg agcatagagt gaatggcacc gacgtttggc gcaatactca 1970641 tttcattatc attaaggatg acaatcatgt cttttttctc gtcgccgatg tggttaaggg 1970701 cttcgagcgc cataccgccg gtcagcgcgc cgtcaccaat gatcggaata atatattcat 1970761 ccgttccttt aatatcacgg gcagctgcca ttcccatcgc gcctgacaga gaagtcgagc 1970821 tgtgcccggt ttcccaaaca tcgtgctcgc tttcactccg ctttggaaat ccgcaaagcc 1970881 ctttgtactg gcgaagcgtc gcaaattctt ttccgcgtcc tgtcagcagc ttatggacat 1970941 acgactgatg gcctacatcc cataaaaatt tgtctttcgg gctgttaaat tccttatgca 1971001 gggcaacagt aagctctacg acacctaagt ttgggccgat gtggccgccg gaagcggata 1971061 aacttgtaat taaaaactga cggatttcat cacttaattt ctctaattca tcaatggaca 1971121 tgttttttaa aaacgacggg tcctgtattg ataaaagatc caaagcggat caactcactt 1971181 tcagcatgaa tttctgcaat gatacatgtc ttttgcatgc cgagctgaca ataatctcag 1971241 acataaaaaa agacaaacgc gcttttcctt ttcatttttc atataaactg cttacatttt 1971301 accatacctc gtgcagccgc ttcaaattag gatcgtttta gtgatctctt gccgcaatta 1971361 aatcacaaag ctcatataaa aggtcttttt gaagagagag tccgccgatc aatcgcttcg 1971421 cctcttttat atgaacatcc aatttatgtt tggccccttc caatgaaaga agcgacgggt 1971481 atgtcgattt gtcatttgtg gtatccgagc cgacacgttt gccgattttc tcttcactgc 1971541 cttctaaatc taaaatatcg tctctgattt gaaatccgat tccaatgtgg ctgctgaagg 1971601 tacgcagtgt ttcaatgtct tcctcaggcg catcagccaa aatagcaccg gcgattacac 1971661 aaaagccaag gagcttggca gttttccgtt catgaatgga ttcgagctct tcaagcgtga 1971721 cttgtcggtt ttccgcttcc atatcagcta cttgcccacc gaccatgcct tcggtgcctg 1971781 ccgctgaaat cagttcattc acaagccgca ggcgcttttc tgctgacacc tcgtctgaca 1971841 cgtgggaggt aatcagctta aagctttctg tgagcagccc gtcacccgct aatactgccg 1971901 tcgcttcacc aaacacttta tggtttgtcg gcttcccgcg gcgcaaatcg tcatcatcca 1971961 tgcatggaag atcatcatga attaacgaat acgtgtgaat catttcgaca gcacagccca 1972021 ccggaatgcc gtctttttcg ctttttccat atgcatttaa aacagccagt acaatcagag 1972081 gccgcaaccg ctttccgccg gcctgtagag aatatagcat agatttcttt aatgagtccg 1972141 gcatatcaag cttttctgta tagacagaaa gctgattttc aattgttttt ttccggtccg 1972201 ccagaaagct cgttaattta tttgtcacct tcgtcttcct cctgaacact gaaaggtgcc 1972261 agttcgccgt cttcttttaa aatgaagtcc atttgctttt cgactttttg cagcttttca 1972321 tggcacattt ttgacagagc catgccttct tggaaatagt taatggcttg ctctagaggc 1972381 acatctccct cttcaagctt tgatacaatg ctctcaagcc ctttcatcgc ttcttcaaat 1972441 gtcatgtttt catttttttt cacgtctgtc atttttcttc ccctctcttt tctaatactt 1972501 cacaggtcag cacgccatcc ttcagcttga tttcaagccg gtcctgctct tctatttgac 1972561 tgacactttt aatgagttta tcttctttat aagccaagct gtatcctctt tccatcactt 1972621 gaagaggact tagtgcattc agcttgccaa gaacggtttg aaattgggaa tgcagctgct 1972681 tcatttggat attcatattt tttctcagct gatttgtttg ttcctggtat cgtgttctcg 1972741 cttgtttcag ctgttcatga ggatgcaatg cctctaatct gtacgtttca cgctccagct 1972801 gtctgctttt ccgatctaaa agagcggtca gctgtgcttg aaactgctgg tacgcgaggt 1972861 caaactgctg ctctttttgc gcatacaaac gctttggaaa acgaaaggca taggacgatt 1972921 gcagcgtttg tatccgttct tttttctggc cgagatgctg ctgcattgct cttgtcattc 1972981 tgacttccgc tgtttttgtc cgttcgatta aatcagtggt atgaggcaca gcaatctcag 1973041 ctgctcctgt cggcgtcgca gctctgatat cggcgacaaa atcactaatc gtaaaatccg 1973101 tctcatgtcc gactgccgat ataatcggaa tattggaagc aaagatggcg cgtgctacaa 1973161 tttcttcatt gaatgcccac agttcttcta tcgaaccgcc gcctctcccg acaattaata 1973221 cgtcgcaaat ctctttttca tttgcctctt caatgcgcgt aacgatggat ctgctcgcat 1973281 tttcaccttg tacgagcgct ggaagaacaa tgacttttac aaggggatat cttcttttta 1973341 gagttgtaat aacgtctctg acagcggcac ccgttggaga tgtcacaacc ccgattgtgg 1973401 ctggaaatgc ggggatttgt tttttgtagc ggtcgtcaaa taaaccttct ccggcaagct 1973461 tcttttttaa ttcttcgtac gctaaataaa gcgctccaac cccgtcaggc tgcatttctt 1973521 tggcatataa ttgatagttt ccgctcggtt catatacgga aattccgcct ctgaccagca 1973581 ctttcattcc gttttcaggt ttaaaaggca gacgctcgct ttgtctcgcg aacatcaccg 1973641 actgcattct tgcgttttcg tcttttaaag tgaaataaat atgccctcgt gtgtgtatct 1973701 ttacattcga caattcgcct ttaatccaaa tattttcaag gtgaggatct acatcgaatt 1973761 ttcgttttat atactttgtc agcgctgaga cggtcacata cgctgcttca cccatgtcta 1973821 aaaactcctc tcctaagcat tcctgcacca taactaaaga aaacccgccc tggctttagg 1973881 agcctgaaga agcgggtatc gtgctcatat tcaaggcggg taaacatttc gcctgtgaat 1973941 atctccaatt atctatgata acgtacgttt cgcagattta acagtattat gcgcaagcat 1974001 cgtgatggtc atcggaccta ctccgcccgg aaccggcgtt atgaaggacg ctttttcctt 1974061 tgccccttca aattcaacgt ctccgcaaag ctttccgttt tccagacggt taacgccgac 1974121 gtcaatgaca acagcgccct ctttgatctg gtctgcactg atgaagttgg ctctgccgac 1974181 tgccaccacc aggatgtccg cttttttcgt atgttcagta atattttctg ttcttgaatg 1974241 acagtaagta accgtcgcgt tttcatttaa taaaagctgg ccgacaggtt tgccgacaat 1974301 gttgcttcgg ccgactacaa caacctcttt accggaaagg tcaatattgg ttttcttcaa 1974361 aagctcaaca attccatgag gcgtgcaagg aagaaacgta tcttcgccaa gcagcatttt 1974421 ccctacgttt aacggatgaa aaccgtctac atctttatca ggggagatac gttcgatcac 1974481 cgctttttca gaaatatggt ctgggagcgg aagctgaacg agaatgccat gaaactcagg 1974541 gtcttggtta tattgatcaa taatggaaag cagttcagct tctgtgaggc tgctgtcaaa 1974601 ttgatcgagc ttgaaattca ttcccattgt ttctgccgct tttttctttc ctcgcacgta 1974661 agagtgagaa gcaggatcat ctccaatcaa aataaccgcc agtccgggag tgacgccttg 1974721 ctttttaagc tcttctacct cttttgccaa ttgttcgcgt ttttctctag ccgtttcttt 1974781 tccgtcgatg attgttgcag tcattttctt tcctcctatg attgttcaat atcagattta 1974841 atgttagaaa gaaccccgtt tacaaacttt gtcgctttgt catcaccaaa ccgttttgcc 1974901 agctcaatcg cttcgttcat ggagacattc accggaatgt cttcggcata tgccatttca 1974961 tatgctgcca ggcgcaaaat cgcacggtca acattggcaa tccgatcgag cttccaattc 1975021 accagatgct tggagatcat ttcatccagc tggtcttggt gttccaatac cccgtgtaca 1975081 agctgttcaa agaaaggatc tgttttttct tcatccagtg cgtgttctat ggcttcattc 1975141 actgcaatat cgctgacatc aatttgaaat agtgcctgca aagctttttc tcttgctgtt 1975201 cttcttttca ttttctttct cctttgatcc tctttatccg cttgtcgtta agccacaaag 1975261 agatcataac atattttttt cgtatccgca tattgaaatc aaggtttttt taccctatta 1975321 ccgaatattt tcacacacct taatatgatt attcggattt cacgttcatg aagaaactcg 1975381 gctatgtaag ccggctttct tcatgctttg aaataaaggg taacgtgtaa aaaaaccaaa 1975441 gggccgccct ccccttggtt tcgtgttaag ccatttacat ttcttcgtcg atttggactt 1975501 cttgggcttt tgtgtcaaat tgaatgccga cgatgtgaat attgatctcg ttaatcgaaa 1975561 gagacgtcat atttaataag gtttgacgaa tgttttcctg aacggatgct gcaactttcg 1975621 gaatcgaaac gccaaatgta acgacacagt atacatcgat cgtaattccg tcatccgcca 1975681 ggtcgacttt gacacctttg ccatgattca ctttgccaaa gcgctcaacg acgcctgtcg 1975741 caaagtttcc gcgcatttcg gcaactccat caacttctga tgctgcaatg ccggcaatga 1975801 cctcaatgac ctccggtgca atctcaacct tacccaaatg cgtatcttcg tgatccattt 1975861 taagcaagct gttgtctttc attcaattca cctccgtaaa aattatgagc ccattacatc 1975921 atatgtttct aaaaatttcg tattaaactc tccgctcaca aatgtttcgt gttcaagcag 1975981 ttttaaatgg aaagggattg ttgtctcaat gccttcgatg acgaattcgc tcaatgcgcg 1976041 cttcatgcgg gcaatcgctt catctctcgt ttttccgtat gtgattacct ttgcaatcat 1976101 gctgtcatag tacggtggga tggaatagcc agggtacgca gctgaatcga cacggacacc 1976161 aagaccgcca ggaggcaggt acattttaat ttcaccaggt gacggcatga aatttttgct 1976221 tgggttttct gcgttgattc ggcattcgat ggcccagcct tcaaattcaa catcttcttg 1976281 cttgaggctc agttccattc ctgaagccac tttgatttgt tccttgatca ggtcagttcc 1976341 cgtcaccatt tctgtgactg ggtgctccac ctggattctc gtgttcattt ccatgaagta 1976401 atagcgctgt tcattgtagt catagataaa ttcaactgtt ccagcacctg tatagccaac 1976461 cgctttggca gcctttaccg ctgcatctcc catttgctcc ctgatttctg aatcaagggc 1976521 aggagatggt gattcttcca aaagcttttg caggcgtctt tggatcgagc agtcgcgttc 1976581 gcccaaatgg atcgtatttc cgtagttatc agcaagcact tggatctcaa cgtggcgaaa 1976641 atcttctatg tatttttcga tgtatacacc tggattccca aatgcagttg ccgcttcctg 1976701 ctgtgtaatc ttaatgccat taatcagttc ctcttcagtg cgggcaaccc taattccttt 1976761 tccgcctccg cctgcggtgg cttttataat tacaggatac ccaatttcat tagcaagcga 1976821 aaccgcttct tccacatttt ctataattcc ctgtgaaccc ggtacgattg gcacgccggc 1976881 ctgtttcatc gtttcccgcg caacgtcttt tgttcccatt tttgaaatgg cgtcagcgct 1976941 cgggccgaca aacgtgacat tcacttcttc acataattca gcgaaatcag cattttcagc 1977001 taaaaatccg tatcccggat gaatggcgtc cgtgccagtc agctttgcaa cactcacaat 1977061 atttgtaacg tttaaatagc tgtcttttga tgctttcggt ccgatacaaa aagcttcatc 1977121 ggccatttga acatgaaggg catctttatc agcttctgaa taaacagcga cagtctcaat 1977181 tccgagctct ctgcaggctc tgatgattct gacagcaatt tctcctctgt tggcgatcaa 1977241 tagcttttta atcatgttca gtctccttac tccgctttta caagaaatag aggttgtccg 1977301 tattcgacca gctggccgtt ttctactaat acttcaacga tttcgccttt cacttctgct 1977361 tcgatttcgt tgaaaagctt catcgcttct acaatgcaga caactgtgtt ttcatttact 1977421 tttgaaccgg ctgttacata cgggccagct tccggtgatg aagaagcata aaatgttcct 1977481 accattggtg aagtgatttt atgcagattc tcatcttgct ttggtgcttc ttgggcaggt 1977541 gccgctgctt gctgcgcttg cggctgaact gcctgcggag cctgtgcttg tacaggtgct 1977601 gccggtgcct gctgcatgac ttgaaccgtg cctgcttcgt gttttttcag ttttaaggat 1977661 acaccttcat tttcatatac gaattcgtca attgtagact cgtcaattgc tttaatcagc 1977721 tcgtggattt ctttgatatt taacattcaa tcgcactcct atgtatgaaa tttctttttt 1977781 tataggttac tactaaaagt acatactatg ttcatcttac aggagcggac ttttgaattc 1977841 aactctaata tgacagcaac gcaaaaagcc cgcttgttta gcgggctttt ttccctcatt 1977901 cttatttaga gggttcaaat gtgacagcga catctttcat tgttttgatt tcttttgcca 1977961 caaggtctat aatggctgtc gccttcgatt tagagtgttt gtctgatttg actgtaatat 1978021 tgattttatc tccttcagca ttaacaagcg catcctcgta accttgtgtt ttaatcagcg 1978081 tttccagctg tttttctgtt ccttccactt cactgagagc cgtcatttta tcgtatgctt 1978141 cgcttttctc cttggctgtt gcatcatcgc ttgacacaat ggcattcagc tcttctcttt 1978201 ctttgcttct ggcatcttct aaatcaagac ggtacgttgt aaacaaatca tcatcggctg 1978261 tttccgtaac aacagttcct ttttcactgg cttcagcgga tgtttccttg tctgctgatg 1978321 aatctttcgt tccctttgtt ccatcttctt ttcctttttc agtttctgta ccgctttttt 1978381 ccttcgtgtc ttgcttggca ggcgcttttt cagttgcgac ctctccgctg tcagacgcgc 1978441 ttttttcact ttgcatctgc acggcgtttt tgctttccgg cgacatgata tagtagacgc 1978501 ttaacaccac gacaagactg agcattgtta atagccaaac ggtttgtttt ttaagcattt 1978561 atgaatcctc ctttattttt ttaggggcaa ccgcaacccg gtggcttgga acatccagga 1978621 cccgtgtcac cgcttcgata atggtttgtt ttatttgaac gttgtccact ccttgagcaa 1978681 caacgagtac accgcgtata tcaggttttt tcgtttggac gacgacaggt gtttctttat 1978741 cgccgttttt gatcatgacg atttcttcct ccgatgattg gtctgtaacg cttctttttc 1978801 cgccttcttt gtcagtttct tcagtggttg tatttttgtt tgatttgttt ttttcgtata 1978861 ctttcagcga cgttgcatct acattcacga caaccgagac atcgtccaca ccaatgattg 1978921 tttcaagaat ttctttcagt tgattttcgt attctttttc atagtcatcg atcgagtctt 1978981 taggtttatc agattttgag gctttaaaca cttcggctgt tttctctttg ctgtctgcgg 1979041 aatgttgtga tgatacggcc gttatcgttt tggcgttttc agttttctca ggtgaagaaa 1979101 acagctggct gacaagcata aaggaaactc cgagaacaaa aacgaataga aagtaatgat 1979161 atttggtcag cttcggcttt tcgccgtcct tcgtttgtcc cggaagaaac tgctttttca 1979221 atacattcca taatccgttt ttattcattg ccgacactct ccccgccttc catatgaacc 1979281 gtaattttct cacttccgat ttcccaaatg tccgcgagct gcgtttgtat ctgtttggct 1979341 tctttttgtt cggctgcttc ttttgttacg tatgcatgat ctgtatcaat gtggaccggc 1979401 gcgaccgttt ggaccgtttt ttcagaagac ggggccatat acacgctgat tgttttaata 1979461 tcctcttctg aatctacctt ttctcctgcc gtgagtttga tgcggcctac tttatattca 1979521 tcatgactga atctctcctc cgctttcttt tttagttgga cagccatttc ttctagaata 1979581 tatgcgcgct gggaagcttg tatttctatt ttttttgaat tgatttgatt ttttatgtcg 1979641 gcagactctg actgcccgtt ttttgtgagg tattcaaaga tgacttcggg gtctgtcttg 1979701 aaaagtttaa aaatcggcgt aagcatgacg acaatcaaga gcaggctgac taccattttt 1979761 gcgtactttt gcatgctgga gctcggcagc agcatatcaa tcacaattgc aaataggata 1979821 aacaacacga tggtggtaag ccattccgtt aaaaaactca tttgcctgcc tccttcattt 1979881 catcatcatc gtgaggtttc cggctgtgat tatgacagta aggcttaaaa aaaacatgag 1979941 agacacaatg gcgagagctg caaaaatata aatgacgctt ttgctgatga cgtcgaggca 1980001 ggtgatgacg ggcccgcctc ctagcggctg aagaatcgcg gctgccagct tataaataaa 1980061 agcgagggaa agcactttga ttgccggaaa tgccgcaata cagatcaaaa tagcgacacc 1980121 gagaatccct accgtatttt tcagcagtaa agaggcgctg attactgtat ctgttgcgtc 1980181 tgtaaacatt cggccaagca caggaataaa atttccggtt ataaatttag ccgtcctgag 1980241 cgtaatgccg tctgtcactg cagctgacgc tccctgaaca gagatgacgc cgagaaagat 1980301 ggtaagaaaa acagccagtg ctccgatggc gatatttctg agcaggttag ccagctgcgt 1980361 tactttgtat tgttcagtca tcgtgctgac aatgctcaga atcgctgata aaaaaatcag 1980421 cggcatgacg atattctgaa tcaagagacc gctcgtgttc atcaggaaga ggataacagg 1980481 atgaaagaag gcagcagata cagctccgcc tgaggaagcc aaaagcgcca agaggagcgg 1980541 aatgagcgcc aggataaagc tggtcatcgt ctgaatcgcc tcagttgcat agttaattgc 1980601 cacatgaaag ctattaagcg caaggataat cagcaccatg tacacaattg agtaagcgac 1980661 cttactgacg gtgctttgct gaaaagcatt ttgcaaaagc tgcagaatga cgcaaaaaat 1980721 cgtgagcaaa atcaatgtgc ccagcagctt tccgttggca agcacttcat gaaacaaata 1980781 agaaaagaga gctttcagcc attcttgcgg tgagaatgat ttatcgccat tgataaactc 1980841 cattaagctg cctttttggc tttccggcag cagtccgccg tattctgtca taatgtcatt 1980901 ccaaaattcc ccgatcttat ctgtttcaag cgaggctgct gtcctttccg ctaattgctc 1980961 ggctgtttca gcatggtctt ccgtttgttc tgcattacca gctgcttgta caatttctgc 1981021 acggcctgct atgatcagca cggccaaaag caaaacccat tgaaagcgct tcaatctacc 1981081 gcctcctttc ggttatgaca tagaaggtat aagtccgaga atcgtttcga taatgacggt 1981141 taaaataggc acagccatta cgagtattaa aattttcccc gccaattcta ttttcgaggc 1981201 gatggctcct tgaccggcat cttttgtgag ctgtgccccg aattcagcaa tataggcgat 1981261 tccgataatc tttaaaatgg tttcaacata gaccatgttg acatttgcat taatcgcaat 1981321 tttttctatc attcgaataa tgtcgtagat ttggtctacc aaataaagaa aaatggcaca 1981381 tccggcaaaa acgacgatta aaaacgcaaa agtcggcttt tgttctttta caattaaaga 1981441 aaggaaggtg gcgatcagcc ctaaacctac aatttgaaca atgtcaatct gcaagccccc 1981501 ctatccttgg aataaaaaca cagcttttat ctttttaaat aggtcatcta caatcgtggc 1981561 gaccataaat aaaatataga taaaacctaa cagcgtcacc cactgagcat attctttctt 1981621 gcccatctga tccaatatcg tgtgtaaaaa agcgaccacg attcccactc cggcgatttg 1981681 aaatatgaca ttcacgtcta ctcccatttt atttttgctc ccctcacgtt tacatcaata 1981741 gaagaatgag taacaagccc gctaaaaagc ccaaactttt tatcatcttt tcgtttttcg 1981801 cttgcgcctg ctcagcatcc gcttctgagg cttccaaatg tgtcagcgcc agcttgatgt 1981861 gcttttgctg agagattcga tcatgaatcc caagcgtctc gccaaactgc ttcagcactt 1981921 cgtattcgct ttttttcaaa gacagggtgt cccatacctt ctttaagctt tgctcccacg 1981981 ccgttttcgc ggaatcactt cccttgtcca gctgatcact gaatgcggaa aaaagagttg 1982041 aaacaggctg tgcgagctgt ttggcaatct gctgtgaagc agtatgaagc ggtgtatggc 1982101 cgtacatgat ttcagcctcg agggattgaa gcgccgcacg cagctggcgg atttgccgcg 1982161 gccgttctgt ataaatcttc gccatctcaa aacctgtcca tgttgtcgct accacaatga 1982221 atacagcgcc cagcagcttc agcatgtttt cacgcccgtc gtcctagaca gcacatttcc 1982281 gtctttgtca taaatttggc tcactgtgcc cggccctttt gctcttgata attccaaata 1982341 gcggtcaaag gctctttctt cccacaaacg cttcaatgaa ggccgcttca tcaggtcgga 1982401 tatactccag ccatgcgccg atacgattac tgaaacaccg gcatgcagcg cctccagaag 1982461 tgcatctgta tcttccatac gcccgatttc atcgacaatc atcacctcag ggctcatgga 1982521 tcgaatcatc atcatcagcc cttcagcttt tggacaggcg tctaacacgt caattctctg 1982581 accaaattga tgctgcggaa taccgcgaag acatccggca atctctgacc gttcatcgac 1982641 gatccctgtc tttacgggca gcatgttttt tttgccggtg cttgagagcc tcgcaaggtc 1982701 ccggagaagt gttgttttgc cggtttgggg cggtccgata atcagcgtat tcagccagct 1982761 gttttgatat aagtatggaa gcagcggctc cgcaatcccc agcttttgcc gggcaattcg 1982821 tatattaaaa gatgcgatgt cacggaggcc tttcacacct ccgttttccg taatgactct 1982881 gcccgccagt ccgactctgt ggccgcctct gatcgtgaca taccctttct tcagctcttc 1982941 ttcaagtgta tacatactat agttgctgag ccggctcagg atcagatggg catcctcggc 1983001 cgtgcccgca taggacaaat aaacaggttg tcctcttcga atcaattcaa cagggcggtt 1983061 gatccgaatt ctgacttctt cgatttccag ccattgttgt tccggtattt cagaaagggc 1983121 gtttttcatg gattcaggga gaacctcagc gatttcattc aacagagcct cctcctttct 1983181 accgattggc ttctttaaaa tgtatgatgt gaggcagact ttatgacaag cctctcttta 1983241 tttatgaaca cccgccaaaa tcaagacaac acccgtaaaa atcagaatca gctttgcata 1983301 cgaaagctgc ccggcaattt ggtagattcc gacagtcatt gtaatgataa aaatcaacgg 1983361 accgacaata gcgagaatgc tgttaaccac aaccgccttc cggacatcgt tggtcacaag 1983421 catgacaatt gctgccgtca gctcaatcat agaggataaa actcgtaatc ccgccattgt 1983481 taaaacagta gaattgatat ttccaagtaa aaatttcata gcactctccc aacctcccat 1983541 ttttttatat gatatgctct agcttgctga agtagtcttg tcattttcgt ataaaagaaa 1983601 gattctgttt ttgggcacaa aaaaagcctg ctcccatttg ggaacagact tctttttttc 1983661 tttctatgct cttgaaacgt aagaaccgtc tgatgtattg acaacaagtg tgtcgccttc 1983721 attcacaaag aacggcacgt ttacaacaag cccggtttca gttttcgcag gttttgtacc 1983781 gcctgacgct gtatcacctt taataccagg ttcagtttca acaactttca gctcaactgt 1983841 gtttggaagt tcgataccaa gtgtttcatc ctggtacatc atgatatgca cagacatgtt 1983901 ttctagcagg tattttaatt cttcttcgat ttgagttgcg ctcagttcaa gctgctcata 1983961 agaagaagta tccataaata cgtgctgatc tccgtttgca tatagatatt gcattgtttt 1984021 ggtttcgatt tgcgctttcg ctactttttc accagcgcgg aatgtttttt cctgaatcgc 1984081 gccagtgcga aggttgcgga gtttagagcg gacaaatgcc gcaccttttc caggttttac 1984141 gtgctggaag tcaacgacgc gccaaatgcc gccatctact tcaattgtta atcctgtacg 1984201 gaaatcgtta actgaaatca tgtttaatgt cctcctatat tccaatcaca aaataataag 1984261 ttcttttggg gaatgggtga ttgtccggtt gccgttttct gtaatcacga tgtcatcttc 1984321 aatgcggaca ccgcctgttt ctggtatgta aatgcccggc tccactgtga ccaccatacc 1984381 cggttcaagg atagctgaag atctgacgga taatcccggc gattcatgaa cttccatgcc 1984441 gagcccgtgc ccggttgaat ggccgaaata gtcaccgtag ccttttgcag caatatgatc 1984501 ccttgtgagg gcgtcagcct cttttcctgt cattcccggc ttaatatgtg cgacgccaag 1984561 cgcctgagca tcaaatacaa cctgatagat ctccttcaat tgatcactgg gctgacctac 1984621 agcgaccgtc cgggtaatat cagaacaata tcctttataa taagcgccaa aatcaagcgt 1984681 aacaaggtct ccgctttcaa tcagtttgtc actggccaca ccgtgcggaa ggcttgaacg 1984741 aaggcctgag gcgacaatca tatcaaaaga agagctgtct gctccctggc ttctcatata 1984801 aaactccagc tcattggcaa cagcgatttc agaaatgccg ggtttcataa acgtcaagat 1984861 atgtctgaag gcatcatctg caatcttcgc agcttcctct aatatcttaa tctcttcact 1984921 agacttaatc aagcgcaact tttccacgga ttcagccaca ggcactaatt cggcatcact 1984981 gataacggcg ctgtatgaag cgtaagtgcc atatgtcatg ctgttctgtt caaagccgag 1985041 acgcttgatg ccaaacgatt caacagtgtc ggcagtggtc tgaatcaagc tgccgccatg 1985101 ttcaatgatc tcaaaaccct ttacctgaac cttcgcctgc tcagtataac gaaaatccgt 1985161 aataaacgct gctttgtcac ccgatataac agccaaaccc gccgaacctg taaaccctgt 1985221 catatagcgt acattagtgt tgcttgtaat cagcatgccg tcaattccca gctgtccaaa 1985281 caggtttctt aatttctcta gcttcatctt gattctcccc cttgctggct taataagtag 1985341 cgaacagcaa gcttgtagcc ttcagctcca agaccgacaa tctgcccttt cgcaacagga 1985401 gcgataaccg actgatgcct gaattcttcc ctggcgtata agtttgataa atgcacctct 1985461 accacaggaa gactgatgct tgaaacagca tccctgatcg catagctgta atgactcagg 1985521 gcgccggggt tcagaacaat cccgctgtat tgctcctcag cctcatgtat cgcatctatc 1985581 aaatcacctt cgtgattaga ctggaagaaa gtgagctgga tatgtaaggc ttcagcaaac 1985641 tgaaaaagat ctgtttcaat atcggtcagt gtctggcggc cgaatacttc aggctcacga 1985701 ctcccaagcc ggttaacatt cggtccgttc aaaatcaaaa aatgaggcac acaatctctc 1985761 cttttcgcga gggtttctca tgtaaaaaat gttcacttct cgtgaacatt ttatcatact 1985821 ggaaaaggat tatacactat tctctatgca ttcccagcgc acgtgcaagc ttttccgaat 1985881 tcagctcatt gtattcaaat gaaatagaat acccgacaaa cagcccgtaa agcaaataaa 1985941 tgcaaatggt cgtaataatt gtatctgatg tcagttcggt caccgtgcgc acatctggaa 1986001 aaatcggatt aaaaacaaaa aacacgagca gccaaagcac caagccgtat aaaatacccg 1986061 gccacattgt ttttaaacgt ttcaatagaa gaaaataaag aaatgctgcg ccaattgaaa 1986121 ttactccaat caaaatgatg ctgattaccg ttcccagccc atgttttttc cactctccga 1986181 gtacaaacgg ctgcaatatc atattcgggc tgatttcgga aaaatgaaac aaatatgcga 1986241 tataagcaac gaaactccaa agtacgcctc cgcaaaaacc tgttgccgcc accctgccgg 1986301 ccattgaaac aggcggcttt tgcttctcat tcaattcttc attttgttct gtatcttttt 1986361 cgcttgtcat catggcacct ccagttaaag tgtgcccaaa aaatgaaatg tcaataaaaa 1986421 agctcacact ttttggcagc tgcgagtaaa atttgaaaat aacgggtata atgcatgtag 1986481 aaaaagcaag gctatggcaa ttttttcagc ctgtcaatct agaggtttag cgctgtttcc 1986541 tgtacaatag agtgaaagga aatggttagc aatcctaaag aaataggcag gttgataata 1986601 tgtcaaaaca taaagttccg cccgcttacg gcgggcaggc tgttgtggaa ggcgttatgt 1986661 ttggcggaaa gcatcattac gttacagcca tcagaagaac ggatggaagc attgactttt 1986721 ttaagcttcc acgcaaacac aacccgaaac tgaacatcgt gaaaaagata ccgtttttac 1986781 gggggatcgc ggccattatc gaagcgagtg caaacggcac aaagcatttg aatttttcaa 1986841 gcgaacgtta cgggctcgat ccatctgaag acgagacact tgagcaggaa gaaaaaaaat 1986901 cctctgggct gtctatgtat ctcagcctcg cagttatagg cgtcctatca tttttgttca 1986961 gtaaattcgt atttacattg gttccagttt tcttagcgga actgacaagg ccgatttttt 1987021 ccttgaacac agcgcaaatc gcgattgaaa gcctgtttaa gttgattttg ctgctcggtt 1987081 acatctattt tttgtccatg acaccgctta ttaaaagagt gtttcaatat catggagccg 1987141 aacataaagt cataaactgt tatgaacaga atttgccaat tactgtggag aatgtccaaa 1987201 accaatctcg gcttcattac cgctgcggat caagctttat tttatttacg attattgtcg 1987261 gcatgtttgt ttatttactc gttccgacag atccgctttg gctgcgtgtt atagatcgtg 1987321 tcgcactgat accggtcgtg cttggtatat cctttgaagt tctgcagctg acaaacaaag 1987381 tgcgtgacat tcccggtctg aaattacttg ggtacccggg actttggctt cagctgttaa 1987441 ccacaaagga acctaaggat gaacaggttg aagttgccat cgaaagcttt aacgaacttc 1987501 tcagactcga agcattgtct gagcaaaatc agaagccttc tcacaacgtc atctaaaatc 1987561 cgttgccctg ctattacttt cggaggtgga cagttatgaa tcatcgtgta caacctatta 1987621 ttgctgtatt aattgcgctg ggagcgttcg gtttcctcta tgtgctggta accaatcccg 1987681 gagaaatggc aaaaatggcg gtaaccgtca tcgtggcagg tatcattatt tattttattg 1987741 tgaaatatgt aatgaatcga aatgcgggca gcgaaggagc agccttcaaa aaagcggcga 1987801 aacaatcacg gcgccggatg aaagaacaaa aagcaaaaca ccgcgccgga cataagggac 1987861 gtgtcagcca cctgcgaagc gttccgagcg ccagcaagcc taagccgatg attctcaaga 1987921 aaaaaagcca gactcagctg actgttatag aagggaaaaa aaataaaaag aaaaacagag 1987981 cgctttttta ataggtccac tgctttaaaa acagctctgt ccgtctttta cctagctcaa 1988041 tcagggctag ttttttttgt tgtgttaaat gaaaatcagt ggccattacg tcatcaacag 1988101 ggagaaaaat gatattttgt tcatagcgtg acgcaatgtg ccttgcgtca tgagcatcct 1988161 tcatcgtttc aaacagggcg ccgaacagtt caaaagcgtt gcggatattt tttttcggac 1988221 gctctctttc acgcggcgca agcgtgacac cgatcacagg gcgctttctt tcctttgaaa 1988281 acagccagat tggaaaattg cttaacacgc ctccgtcgac aaccgtggcg gtgcctgtgt 1988341 ccgtttttaa ttttatcggt tcaaagaaat acggaatgct gcagctcatt ctgaccgctc 1988401 tggcaaccgg gaacatatct ggatttaacc cgtaacgggc caaatcgtcc ggcaaaacaa 1988461 tcatggtgcc gtttgtcaga tcagaagcaa taaggcgcag agaccctttc tgcaaatcgc 1988521 cgaaaaccct tatgcctttc gctcttaaca gatcagcaat ccatttttct atcgtatcgc 1988581 ctttgtataa gccaagacgc cagtagatgg acacccactg gagcatcttt aaggggagaa 1988641 atgagtacct ctgatccagc aatttctctc cgtccacttc ttcaattaaa gcgtggattt 1988701 ccttactggt gtaacctgac gcaatgaaag cggcaataat ggcgccggcg cttgtacccg 1988761 caactctttt aaagcggaag cctttttcct caagcacttc ataagcgcct gcgagcgcaa 1988821 tgccttttac tcctccgccg gaaaacacac cgtcaatata catctcattc cctccccctc 1988881 catccgatcg tttattacca ttttaagaaa acacgcgaag aaatagacca acgaatgacg 1988941 ggtggcgtca gcgtatcaaa aaagacggcc tccttcgaga ccgccttttt actgattatg 1989001 atgttctgtt ttcttttgga ttgatttcag atctttttta cgggcatcat cttcttcaaa 1989061 atattgaaca agatccccga tgcgatcaat actgttccag cttaaatgat gttcgattcc 1989121 ttcgacatcg ttatatattt tctcttcatc aacaccaatg attcttaaaa actgctcaag 1989181 caattcatgt ctgtatacca gccgtttgcc tatttttttc cctttagacg ttaacacgag 1989241 accgcgatat ttttcataaa ttaaatattc gtctttatct agtttttgaa ccatttttgt 1989301 tacagaggag ggatggactg ccaatgcttc cgcgatatcg gaaactcgtg catatccttt 1989361 ttcttcaatc agcatataaa tctgttcaat ataatcttcc atacttggtg ttgtcatcga 1989421 aaccctccca aaaagcacct taactttata aaccattaca agtttacact aatgaacttg 1989481 aaaaaacaag gatgctccgc gggtcaaaag ccctgtttac cgcttataat tccattcatc 1989541 tgaagcgtac tttgtttcag ccaagtgatg aacaaaatca agctcttcct gagaaagttc 1989601 atatggctcc aaatgaatgt taagacctgt ttcaaatcct tctttaaagg ctttacgagc 1989661 ctcatccatc gtcacccgct tttcgatgag ttcattaatg gcaaccgctt tatttttgaa 1989721 attgcgctgc atccgctctc ttactctttc acttggatat aagaacagat cgaacagctt 1989781 gtcctcatct aaatcaagaa gaatggagcc atgctgaaga atcacacctt tttgtctcgt 1989841 ttgcgcgctt cccgccacct tgcgcccctc aaccactagt tcataccacg aaggcgcgtc 1989901 aaaacaaaca gatgaccgcg gattttttaa gctttctttt tctttttcag ttctcgggat 1989961 ggcaaagtaa gcgtccagac cgagatttct aaagccttga agtatgcctt ctgaaataac 1990021 ccggtaagcc tcagtaacag tcgccggcat ctcggggtgc tcttccgaaa caattacgct 1990081 gtatgtcagt tcctgatcgt gcagcacacc tctcccgccg gtcgggcgtc tgacgaatcc 1990141 gagattatat ttatgtactg cttcaaaatt gatttccttt ttaatatttt gaaaataccc 1990201 tacagaaagt gtcgccggat tccagccgta aaaacggata accgggggga ttttcttttc 1990261 gctgtgccaa tataaaagcg cttcatcaag cgccatattg aatgcaggac ttgcattgcc 1990321 tgagtctata aaccgccaag tttctttttg cattttaaga ccttccttac cgttttaata 1990381 gaatcagttt atcaaactgt cgggaaaatg aaaaatattt tagttccatt atagatgaca 1990441 atcacgctgt gctttactat aatagtattt gtcgaaaacg gctctatgac cttgttttat 1990501 gaagcagggt tttgatttta tatgctaaag gagtagaatc acattgtcta atatgatcgt 1990561 tttgattatt tttgctgcat ttatcatcta tatgattgct tcatatgtct atcagcagcg 1990621 aattatgaaa acacttaccg aagaagaatt ccgcgcgggt taccgcaaag cgcagcttat 1990681 tgatgttcgt gagccaaatg agtttgaggg cggacatatt ttaggcgccc gcaacatccc 1990741 gctttcccag ctgaaacaga gaaaaaatga gatccgtacg gacaagcctg tttacctgta 1990801 ctgccaaaac agtgtccgca gcggacgcgc ggcacaaacc ctgcgcaaaa acggctgcac 1990861 tgagatttac aacctaaaag gcggctttaa aaaatggggc ggaaagatta aagcgaagaa 1990921 ataaagcaaa cagctgtctg gtagacagct gtttttattt atctttcttc cgcctcgtat 1990981 ctgagcactg ggtgtctcgc cgcttttgtt tcatccattc tttttacaat cgttgtatgc 1991041 ggggcctcct gaacaagctc cggattctcc tccgcttctt ttgcgatttg aatcatagca 1991101 tcaataaacg cgtccagtgt ttcctttgat tcggtctctg tcggctcgat catgatgcat 1991161 tcttcaacat taagcgggaa ataaatcgtc ggcggatgat agccgaaatc aaggagccgt 1991221 tttgcaatat caagcgtacg cactcccagc tttttctgcc gcttccctga taatacaaat 1991281 tcatgcttgc aatggcggtc aaacggaaga tcgtaataag gcgcgagttt tctcatcata 1991341 taattggcgt ttaacactgc gttctcagta acagccttta atccgtcagg ccccatggag 1991401 cgaatatacg tatacgctct cacattaatg ccaaagttgc cgtaatacgg cttcacacgg 1991461 ccgatcgcat gagggcggtc ataatcaaac gtaaagcgcc cttctttttt gactaaaact 1991521 ggctttggca aataaggaat cagatcttgt tttacgccga cagggcctga gccggggcct 1991581 ccgccgccat gagggcctgt gaatgtttta tgcaggttga ggtgcaccac gtcaaatccc 1991641 atatcaccag gtctcgcctt gcttaaaacg gcatttaaat tagcgccgtc ataatacagt 1991701 ttcccccccg cttggtgtac aatttccgcc atctctgtaa tctgctcctc aaacaagccg 1991761 agcgtgttcg gattcgtcag cataagagct gcagtttctt cattcactgc tctttttaaa 1991821 tcctctaaat caacaagccc tttttcattc gatttcaccg taacggtttc aaagcctgct 1991881 actgttgctg atgcaggatt cgtcccatgc gcggaatcag ggacaatgac cttcgtccgc 1991941 ttgaaatccc cgcgagcttc atgataggca cggatcatca tcagccccgt ccattcgccg 1992001 tgcgctccgg cagcaggctg aagcgtaacc tcatccattc ccgttatttc ttcaaggtgt 1992061 ttgcttaaat catataaaag ctctaatgcg ccttgcaccg tgtcttcatc ctgaagagga 1992121 tgaatcgcag caaaaccagg aatacgtgcg attttttcat tgattttcgg attatatttc 1992181 atcgtgcaag aaccgagagg ataaaaaccg gaatccaccc cgtgattgcg tttggacagc 1992241 gctgtataat ggcgcatgat gtccagctct gaaacctccg gcagcgctgc gtcttcgtca 1992301 cgaatatagg tgtctgacaa gaggtccccc aattcgattt ccggtacatc gagctccggc 1992361 agactatagc cgattcggcc ttctcttgaa agttcaaaaa taagtgcctg gtcctgatta 1992421 ctcatggcga tcccccaatt cctgaatgag tgcgtcaatt tcttcttttg ttctcagctc 1992481 tgttacagca atcagcatat ggcagtccag ctctggatac gtcaacccaa gatcatatcc 1992541 gccaatcatg ccttttgcca gcaaacgctt gttcacagct ctcaccggct catccagttt 1992601 gatgacaaat tcattaaaca tcggcccgtc aaacataaca gtaaggcctg ctttttttgc 1992661 ttcttgcttt gcatagttgg cttttaagag attttggcgg gctatatctt ttacgccgtt 1992721 ttttccgaga gcagtcatgg ccactgatgc tgccagcgca tttaaagctt ggttcgagca 1992781 tatatttgat gttgctttat cccggcggat atgctgctcc ctggcttgca gggtaagcac 1992841 aaagcctctt tttccgtttt cgtcttccgt ttgtccgacg agacggcccg gcacctttct 1992901 cattaatttt ttagtaacgg caaaaaagcc gcaatgcggg ccgccgtatg ctgaaggaat 1992961 gccgaaaggc tgcgcatcac cgacgacgat atcagactga aacttgcccg gcggagtgag 1993021 aagacctagc gccagcgggt tggctgaaac aataaacatg gatttccctt gatgagcgat 1993081 aggctcaata tcctttagcg gctcgatcct gccgaaaaaa ttcgggtact gaacgatcac 1993141 tgcggctgtg ttctcgcaaa cggtttggcg caatgcatca agatccgtaa cgccatccgc 1993201 agcgggtact tcaacaacat caatatactg accttttgcg taagttttca gcacctctcg 1993261 cgattcagga tgcacggttt ttgacacaac aatttttttc tttttcgtgt ggcctgaagc 1993321 aagcattgct gcttctgcca aggctgttcc gccgtcatac atcgaggagt tggcgatatc 1993381 catgcctgtc agttcacaga tcatcgtttg gaattcaaaa atagcctgga gctctccttg 1993441 tgaaatctct ggctgataag gcgtatatgc ggtataaaac tcagagcgcg aaatgacatg 1993501 atccacaatg acaggctgat agtggtcata tacacccgct cctaagaaag aagcgtattg 1993561 tacggtatca cgatttttag aggccagctt tgtcagttct cttgttaatt ctgtctctga 1993621 tttcgctttt ttgatttgat gctctttttt atatttgacg ttttccggta tatcagcaaa 1993681 taaatcatcg atgctgctta cgccgatagt agcaagcatc tcctgtttat ccttttctgt 1993741 tgcgggcaaa taacggtgct tcatgtgttg tctcctctct ccaagaaaaa atattagcgt 1993801 ttataaaatg gtgttttgac aacctttgct ttcactaatt ttttgcgtat ctctacatct 1993861 acaacagtcc cgatctcact cgtttccgaa tcaattaagg caaggccgac gttttttcct 1993921 aatgtcggtg actgcgtgcc ggttgtcacc tttccgacag acttgccatt ttggaaaacc 1993981 tcatatccgt gccgcggtat ccctttttca atcatttcga gaccgacaag tttgcgcttc 1994041 gctccgtttt ctttttgttc actcaatact gacttaccga aaaagtcaga ctcctttttg 1994101 tgctttacag caaagcctat acctgcttca atcggtgtaa tatcccgggt cagctcctga 1994161 ccgtagagcg ggagcttcgc ttcaaaccgg agtgtatcac gtgcaccgag accgcatgga 1994221 atcaatccgt atgcatcccc tgcatcgatg atttttttcc aaatatgcat agcatcatca 1994281 ctgcggcagt aaatttcata cccgtcttct cccgtatagc cagtgcgtga aataagtgct 1994341 ttgcggccgc tgatatcggc ttcatcaata aacgcaaacg gctttaatgc agacacatcc 1994401 gcatctgtca gattttttaa gatcgcttct gctttcggtc cctgtacagc caagagcgcg 1994461 atttgatctg actgattgtc aatctgcaca tcacctgctg catgttcttt catccaagcc 1994521 aagtctttat ctatattaga agcattaatg acaagcagat agcggttctc tcctttttga 1994581 tagataagca aatcatcgac ggttccgcca tccgggtaac acatcgctgt atattgagca 1994641 cggcctggcg ttaacgcgga aacatcattt gtcatcaatc tttgcaaaaa agacagactg 1994701 tcgttccctg acacttcgac ttctcccata tgagatacat caaacaaacc ggctgcagtt 1994761 cggacagcct cgtgttcttt ttttatagaa gaaaattgaa caggaagctc ccagcctccg 1994821 aaatcaatcg tttttcctcc atattcctta tacaggtcaa ataacggcgt tcttttcagc 1994881 atctaattcc tcccctttat caacggcgca gctaaaaaac atacaaaaaa ggacagagaa 1994941 acacctcatg taaaatgaag gttctctgtc ctggcacctg aaagtttact ttgcatacgc 1995001 aaagacgtcc cctttggtgg tttgcgcatc cgcacaaaca ctctccagag ttgcgtcgag 1995061 caagagttct tttgcctgag agattcactc cgcagtttgc tccttcggcg cctgtatccc 1995121 gaggttttcg gtcaggtctc tccccttgct gtcattcgct catattttca tgctgttatg 1995181 gacatactat agcaatatct tacatcaaat acatactcat atcctaccat catcactata 1995241 tgctgggcaa cagcaatttg ggcagatttt tcttatatta ttcatcttaa gaatcgaaga 1995301 ataagaaagg cggtttcaaa gcaatgaata cagaaatgat ctacgatgca aaatggcctg 1995361 aagaatttgc tgaaagactg aaaaacgatg gcccttgggc aaactgggaa ctgtacaagc 1995421 tctctgcaga aatccagaaa acattagcaa ttccagagtt tgaaggctta cgggctcctt 1995481 tatatctgcc ttcctttacg ccgctccccc accagcttga agtggcgcaa aaagtggttg 1995541 aaaaaatgaa cgggaaagcg attttagcag atgaggttgg tctcggaaaa acggttgaag 1995601 ctggactgat tctaaaagaa tatatgattc gcgggttagc aaaaaaaatt ttgatccttg 1995661 tgcccgcttc ccttgtgtca cagtgggtca aagagcttca ggaaaaattt ttgattccgg 1995721 ctgttgaaca aaagaaaagc tatgtgtggg agcaatgcga tattgtcgtc tcatcaatag 1995781 acaccgcgaa gcgctcgccc catcgagaaa tcgttctgtc tatcccatat gatcttgtca 1995841 ttattgatga ggcacacaaa ctgaaaaata gcaaaacgaa gaactatgaa tttgtccgga 1995901 atctcgtaaa aaaatattgc ctgcttctta ccgcgacgcc aatccagaac cgtatcgaag 1995961 agattttcaa tttggtgtcc ttattaaaac ccggccattt aggcagtcag aatcactttc 1996021 aggaggagtt cgccaagaag aaatccagtt tagaagcgca tgaacattta aaagatcttg 1996081 tgaataaagt catgatccgt aacaggcggc atgatacagg gctgaattgg aaacagcgcc 1996141 atgttgaaac agtgccgatt caattttctc catcagagca ggcgctttat gatgaaattt 1996201 ctcgtttgaa ggacagtatc aataaaccag ccagcatgtt ctcgattatg accttgcaaa 1996261 gagaatgctg ttcgagcaga gaagcggtat atatgacgct gaaaaagatg cttgatcaaa 1996321 aagagaaaca agcacctgcc attgatgagg atacgatttc agttttgata gatcgcatca 1996381 atcaagtgac acaaaactct aaagcgcttc aagttgttga cttgatcaaa aagatcgacg 1996441 ataaggtcat catttttaca gaataccgcg caacccagat ttatctgcag tggtttcttc 1996501 agcaaaacgg catcagttct gtgccgttta gaggcggatt taaacgtgga aaaaaagact 1996561 ggatgaagga tcttttccgc ggaaaaatcc aagtccttat tgcaactgaa gcaggcggtg 1996621 agggaattaa cctgcaattt tgcaatcaca tgatcaacta tgacctgcca tggaacccga 1996681 tgcggcttga gcaaagaatc ggaagaattc acagactcgg gcaggagcgt gacgtgcata 1996741 tttataacat ggcgacaaaa catacggtgg aagagcatat tctaaagctt ttatatgaaa 1996801 aaattcattt gtttgaaaaa gtggtcggtg aacttgatga tattttaacg aaaattcaag 1996861 tgaacaattt tgaagagcac cttcatgaca ttttgtatca ctcagcaaca gaagaagaaa 1996921 tgaaaataaa aatggataac ttaacctcat ttttgtctta taaaaaacag ctgcctgctg 1996981 aaaaaagagg atcttagcct gtaaggaggt tttattagtg agacagcaag aggttcacga 1997041 ttttctgctg cgtttttttc aagcaaacag ctgccaaatc gtcgatcaag gcttaggcta 1997101 tatgacagtg cagcttacag ttgaaatgga caaacaaatc atgaaccgcc ctttctactg 1997161 gcattggcgc gagaagacag gcggtgatcc gaatccaatg aaaatcactt ttattacaga 1997221 taaagaaaat gcgccaaaag acctagatgg tgaatttata tattttgggg ccccgcgtct 1997281 ttttcaaata ttcaaagctg ttaaacaaaa tgggagattt accagaatgt atgagaaaat 1997341 tgaatcagcc ggagctaaag tcccacttca gccttggctt ggtataaatg tcacgatttc 1997401 ataccagtcc gacatgaaaa aggataagtt attgtcacta ggtcttcacc tagtctctgg 1997461 aacgataatt gaagattttc aaagcaagct gacccagttt tcactgacgt ctcaaatatg 1997521 tgactattgc ttcaccattt cacctatgat caaaccagaa agcggactta agcgtatgga 1997581 aaactatatt tccaaatccg ctatgcagga gccgtccgac tgggcggaac aggcggttaa 1997641 caggtggaag aatgatatga cattgcttga taagttttac gagcatatag aagaaaaacc 1997701 agaagaatac catctagaaa aacaggcgct gaaaaccttg tatcaaccaa agatatcagt 1997761 tgaaattgaa aatggcggat tgttttatct gcaaaataat atttcaagct aactttttta 1997821 ccattcgaca tcattctcgt tttttttgag aaaatacgat tataataaag gtatattgga 1997881 aaaaaattct ggtgatttaa tggcaaatga cttccagaga ctaatgaagc atacaataag 1997941 tcatggccgg actggctgaa atacataaac aagtatttta ggaggagaaa ctgcatgaag 1998001 aatgcaaaac aagagcactt tgaattggat caagaatggg ttgaattaat ggtggaagcc 1998061 aaagaggcaa atatcagccc ggaagaaata cgaaaatatt tacttttaaa caaaaagtct 1998121 gctcatcctg gtccggcagc cagaagtcat accgtaaatc ctttctgaat gtgctataat 1998181 atcacaagga aggtgatgac attgattggc cagcgtatta aacaataccg taaagaaaaa 1998241 ggctactcac tatcagaact agctgaaaaa gctggggtag cgaagtctta tttaagctca 1998301 atagaacgaa atctacaaac gaacccctcc attcaatttc tcgaaaaagt ctccgctgtt 1998361 ctggacgtct cggttcatac tttgctcgat gagaaacatg aaaccgaata cgatggtcaa 1998421 ttagatagtg aatgggagaa attggttcgc gatgcgatga catccggggt atcgaaaaaa 1998481 caatttcgtg aatttttaga ttatcaaaaa tggagaaaat cccaaaaaga ggagtagtgc 1998541 ctgagcagag gcactaactc ctcttttgtc aataaccatc gagacggccc agtatatgaa 1998601 tactgggccg tctctttttt ttgctgttat taatttttat cctcgctatg cgcgagctcg 1998661 tcttgctcag tattgctcat tttttcaatt ttttagaaat ttttgggatt gttatgtgag 1998721 aatttaaatg catatcccat tattatttgg taataataaa caaagaaagg gtgacagcat 1998781 gatgatcaaa caatgtgtga tttgtctatc tcttctcgtc tttggcacca cagccgctca 1998841 cgcagaagaa acaccgcttg taaccgcccg ccacatgtcc aaatgggaag agattgctgt 1998901 aaaagaagca aaaaaaaggt acccgctcgc acaggtactg ttcaaacaaa aagtatggga 1998961 ccgtaaaaga aaagatgaag cagtgaagca ataccattta actctgaggg aagggtcaaa 1999021 agaattcggc gtttttgtga cgatttcatt tgatccttat agccaaaagg tcaataaaat 1999081 tgccatatta gaagaatatc aataaggtcc tccatttttt gaaggacctt attcgtttat 1999141 ttgcggttat tttttccgtt tcagccaaag tcggaagcca tagggtaaaa taccgaacca 1999201 ctgctgggaa acaggcgttt ttgtttcttt ccgcacctct tttcgttctt ttcgctcatc 1999261 tctcggagta tctatatatt tgacaaattg ctgcgtcata tatttaacat aatcattcgt 1999321 tttcacgtga tcacctcatc attcaattat tatgagtgtt gtctcacatg acttttttta 1999381 taccctttac actgttttat tctgtccatc tcagcagttt tttctgtttt tggtcaaaca 1999441 cgatctgtgc agttctttct gttcccgaat ccgttgacac tcttaagttg atttcttttt 1999501 gttcttttat cgatgtatca tgaatgtaat aagaaacccg tccatataga aattgctgcg 1999561 taccctcctg gcctttccgt tcctctagaa catgccgaat cgaaagaagc accccatttt 1999621 gaagcaaatt ctctcctatg tataactctt ttgtttcctt ctcaaacatg cagcgtgaaa 1999681 tatattgagc agcaacaaag ttcacgatta acagcacaag cgctgacaca aaaagaacag 1999741 ctggataaat aaaccctctt gtacgataca ttcacccccc tcctaaatac gaatagactg 1999801 gaaaagcagt ttgatacact ttttggtctt cactctcaat tttcagcaaa acaacaccat 1999861 tttcaatatc agctttcatg gcagtaatat gatctaaaat cggaacatgc cctttgccat 1999921 ccactctttt tcttatcatt gaatgataaa tgtcaaaacg gatgtcttgt ccggaaagat 1999981 tggtgcagat taacacgctc ccatgctcgg ctgtcttaac tgcctgtgat tccttgcatt 2000041 cattcatcat ctgttctatc gaaatcatcc attcctgctg tgtgaaaccg tcatgttcct 2000101 gctgtcgaga caaaaacaga tggataatcg cagctaacga tcctgatatg agcaaaaaga 2000161 ctgagagcga aaataatacg ttaagaagcg tgtagccatt ctgtctgcaa aatgctgagg 2000221 caaaatgatt tttctttata agctgcggct ttgatacata cgttttgata ttcgccctcc 2000281 tcctcccact tcattgcata gatatgattg ttctttgtaa tcgtttttga cgcggctcct 2000341 tcaccactca tgacatattt gctaatgctc tcattcatca tctgatagcc aatttctcgt 2000401 gattccgcca ttttttcatc agccatcagc ttgtcccaca aggggacgac tgtcagcagc 2000461 acaaacagcc acaggcttag cgcagacatt gtttctattg tagaaaaacc tttattttct 2000521 ctccacattg actctcccgc tccctagata aactgttatg tcataaacgg catggccttt 2000581 tactcgtatt tttccgcctg cattcgggtg ccctttctca ttaaattcca aacggtcttt 2000641 taatgtcagc agttctatag aaagtcccgt tgcatacgga cgttcaataa ccgtatcacc 2000701 aatgactaat tgatattctt ttttatgaaa gagaattttt gttctttgtt gacgggaaat 2000761 agcagtctgc tgtgtgagca taatatcatt tttcagctga cttgctgcct gtcggacagc 2000821 tgtattgtca taagcaggag gaagtgtagt gaagacggcc accaggagga tagaggcaag 2000881 gcttaacaca agcaaacttt ctaaaagggt aaaccccttc tcctcgttta atttaatgtt 2000941 caaccttaac ttctccgccg gtgatgataa tgcgcttacc atttggacag acagcatcct 2001001 ttttcacata gccctctgac tgtaaatcgg caaggctcgg agtttgtcct tcatgatcaa 2001061 gctcaaatgc agtcatttgt gccttaacca tgttttgtaa gccttcacag cccttttttt 2001121 gaatggtttg attatgtttc gtgacgttcg gtatcgtaat taaaagcaaa atcgaaataa 2001181 taaagagcac gattaacatt tcaacaagtg taaatccttt ctcattcatc agcctcttcc 2001241 tttcacattt gattcatcat ctgatacata ggcacaagca tagataaata cacaagtaag 2001301 atcatcgctg caacaaatcc ataaatcatt ggctgaagga tgcctgtcca tttttgcgct 2001361 ttgtgttcca gccgctgtaa tatgaattgg ctgtatgtga aaagctcccg atccaatcgg 2001421 ccgctcagct ggccgtgaga tatgactttt gataaatcag tttcataaaa aaggcttcca 2001481 caaatagcgg attcaattga ctcaccggct tttagccgtt caatcaattg ttcagcctcg 2001541 cagcggtaga aagggagaaa cgtttgatgt ttaaatgcat taaggctgtc ataaattgag 2001601 aggcctgatt ttaaaaggct gcttagctgc aaagaaaaaa agtagctgtt aaacagcttt 2001661 acaagctttc caaccaaagg aatcctgata caaatcagca tttgccgggc aggtgatttt 2001721 ttcttaaaca caagccaata ataaatcccg atacctgctg taaaaagaac aagcaaaatg 2001781 atcacaagat caatatgctg aaaaaaagca aaaagcatat cggttgaacg tgaggtttcc 2001841 atattcatcg attgatagat accggaaaac tgaggaatga tgatggactg taacatataa 2001901 aacatgacag cgaccgtaaa gatgaggaaa agcggatagc gcagcactct tttcagctgg 2001961 tctgcctgtg caatttttcg ttccagcagc tctccgctct ggatcattga agcaggcagt 2002021 tcaccatgtg tttcagcaaa ataacaaata cctacggctt ccttatgaaa tgacaaactc 2002081 tttagtactt gataaaacgg agccccttcc ctcaaacaag tgaccgaatc agtcaagtca 2002141 gccgcctgcc tcttattcat ctgaagttcc atcaggcgta atccatccag aagtgtatat 2002201 ccgcccgcag tcatttcacc gagcctcttt aataacctgg cttgatcctt taacaaccag 2002261 acttttctaa tctttttcat gataaaccca ccggtcatag ttgtttgtcg ttaaatagcc 2002321 gagcgcaatt ccttttctga taatttgacg aagcgtttga tattggtaat ttgcatgatt 2002381 tccttttgcc tcctggatac attgctgaag atttttcccg tatagaagct cataaacgct 2002441 agctctccta gtatttcgtg actgtcggca atacactgat gaacatccgt tttcacaaaa 2002501 cgggcaagcc aaatcaacca agcgctgagc cgctattgca atgacagtct gttcgatttc 2002561 attcatattg ataccgaatt caagcagtct gtaaattgcg ccctttgcgt ctctcgtatg 2002621 aaggctcgtt agtaccagat gtcccgtcat cgctgcccgc accgcaattt cagctgtttc 2002681 cgcgtctctg atctcaccta aaataatcat atcggggtca tggcgcaaaa ttgctttcag 2002741 acctgcggaa taagttacac cggctttttc attcacctga acctgaagaa catcttcgtc 2002801 ccttgtttca acagggtcct ctaatgtgac aatatttcga ttaaagtgtt tttttgcata 2002861 ttgaacgaga gagtataatg tggtagtctt ccctgaacca gtcggcccgg taaaaatgag 2002921 catgccatgg gaatgtttta aaaacgagag taatgtggct cctgtcttcg gaaatagcga 2002981 caatttatca atcgaaggga tattgtattg gggcatcact ctgatcacga ggctttcttc 2003041 attaattgtg ggcagcgttg acattcttaa atgaacattt ccctctttca actttaacgt 2003101 aagcgaaccg ttttgcggct ttcgcctttc acctatatcc attgctgaaa gaaatttaaa 2003161 atgtgaaatc agtcttacgc actcttcttt tttcatgtcc ctttttttca gcaaggcatg 2003221 atcgacccga aaatgaatga tagcgtcccg ctccctcggc acaatgtgaa tatcagaagc 2003281 ctttgttaga tatgcctctt caatcaagtt tttgcttacc ttttctattg aatccaattt 2003341 gattccctct cctttcaacg catattgtag aaaaagaaga aaaggtaatc aaacagggaa 2003401 aacgtgattt tgtgagatgt tatatgctga aaaaccaatt ctttctggca agaaaaaaga 2003461 ctttcaactg aatgtacccc tgtcattata attttcccta taaataaaaa agcagacatg 2003521 gtcaccatgc ctgctagatt ccattttcat tatgctgttt tcgcttattg accagtatct 2003581 ttctcaacgg aaagatcgcc taatgcaaca ataccggtca tttggtcatt ttcaagaatc 2003641 gataaactgc ggatttaatg ctctgtcata agccccttga catcgtatcc ggtcaccctg 2003701 atatgtctgg tgaaaaagcg gggcacgctg cacaaaatat gaaacatcct atagagtccg 2003761 cctttttcga ggtttctttt tcttcttccg ctcctgcagc atatctcccg tccagccttt 2003821 ttttctcaaa tagagataga tcagaactgt agatgtgaca atcaataaga gggaaaagag 2003881 atatccgtat ttccaattca gttccggcat cactgaaaag ttcatccccc ataaggcacc 2003941 cagagctgta atcggagtaa aaagcgtcgt gaaaatggtc agcgctttta caatttcatt 2004001 ccccctatgt gaggtaatga cttcctctga atgcagcaga ttgttaagct ccccttcaaa 2004061 ttcgctgatg tatgtaaatc ccctgtcaat cttcagttgt gtccgctgat aatccttttt 2004121 cccttcattt tgaggtaaaa aggtttcttt caacgccatt tcaatttttt tagcgcttaa 2004181 tatcaaattt ttccaaatca tcagttcatg gcgcaggaga tggacgcggt ttaaaatgct 2004241 tttgctattg tcgtctttaa tttgccatct gagctttctc agcttgactt caaattcatc 2004301 aacaccgatt aaatacgcat tcattagttc gccgagaaga attaaaaacc cctctatcgc 2004361 attgtccgct ctttccattt gccgaacaac ttctttgcct ttaatctctc tcaaaattga 2004421 aaagtcaaag ttgattgtaa aaaaatattg tctggtgata taaaagtgaa aaacagtatg 2004481 gtctttttct tcaccaagcc cctgatcata aacaatcgac ccaaatactg cttcattttc 2004541 cgtttcagtt gtatctactc gcaaaaaatt aacgtgatgg ttattttcaa accacttttc 2004601 acactgaggc cagtgagaaa aatggattag atctcttgcc ttacttcttt cttgaggccc 2004661 catttggtac caaaaccaat cctttcccgt atgtgccttc atgtcaagct cctccaaact 2004721 tttgttcttt attctttaat tgcccaataa ccgcgtcact aaaccagtct gccgcttcaa 2004781 cacatgtttt atgagcattt tcaggtggta tggaatgtag aaagacatcg gaaaagggag 2004841 gtgcatgcct tccttggaga aggcagttgt tttggaattt atcaatttac tagcagtcgc 2004901 tattctcatt ttgttaacag gatttttcgt tgccgtagaa ttttcaatcg taaaagtgcg 2004961 gcgatccaaa attgatcagc ttgtcgcaaa aggaaagaaa ggtgctaaag cggcaaagca 2005021 tgtcatcact caccttgatg aatatttatc agcctgtcag ctgggcatca cagtcgcagc 2005081 tttaggactg ggatggcttg gggaaccgac tgtgcaaact ctgcttcgac cgctttttca 2005141 taaagcaggc ttaaatgaat cgcttaccca cctgctttca ctcgtcatcg catttttagt 2005201 ggttacgtat ttaaatgtcg ttattgggga gctggcgcca aagagtttcg ccattcaaaa 2005261 agcagaaagc attaccttgt tgttcgctaa accgcttatt tggttttata agatcatgtt 2005321 tccattcatt tggctgttga accactctgc ccgattgatt acaggagtgt ttgggctgaa 2005381 gccggcatca gagcatgagc tggcttatac agaggaagaa cttcgggtcc tattggctga 2005441 aagctataaa agcggcgaga tcagaaaaag tgaattaaag tacatgaata atatcttcac 2005501 ctttgataaa cgaatggcaa aggaaattat ggtgccgcga aatgaaatgg ttagtttgtc 2005561 actagatgaa gactccattt caaatcttca ggaaacagtc aagcaaacaa aatatacacg 2005621 gtacccggtt gtaagagagg ataaagataa cgtcattggc gtgattaata tgaaagaagt 2005681 gctgttttcc atgctgacga aagatttttc aatcaagaag catcaaattg aacctttcgt 2005741 acagcccgtt atccatgtaa ttgagacgat tcctatttat aaactattgc tgaaaatgca 2005801 aaaggaacgc actcatatgg cgatcctcat agatgaatat ggcgggacgt ccggtttggt 2005861 cactgtcgag gatattatcg aagaaattgt aggagaaatc cgtgatgaat ttgatgcgga 2005921 tgaagtgcct catatccgcg aacttggaaa ggatcattac ttgttaaatg caaaattatt 2005981 aatcagcgat gttaacagcc tgcttggaac cgatttatca gaggctgaag tagacacctt 2006041 gggcggctgg tttttgacac aaaacataga cgctgagcct gaaagtgcca tagaatatga 2006101 tggctactct tttaaggtaa aagacatcaa cagccatcac attttattta tagaagttaa 2006161 aaaagctgaa tagcccgtga aaggctgttc agctgctatc tttcaagata aacatggcaa 2006221 aggcatcaac actcttttat tttaaaccct ttattggcca gggctttagc aagactttgc 2006281 tctgttttca cattcgaaaa atccagaccc agcttcacga cagtttgggc aatttccggc 2006341 ctgattcctg aaataatagt ctcaatgccg agcaatttgg tgctgtcaat cactttaaaa 2006401 atttgatagg ctaccatggt atcaacgata ggaacgcccg aaatatctaa aaataaatac 2006461 gagagcttta acgctgagca ctgctccagc acagactcca aaatcgtcct cgctctgtgc 2006521 gtatcaattt caccgacaag cggaagaatc ccaattccat cagtaatcgg cataatcggc 2006581 gcactcaatt cattaatcat ttctttttgc gcgtttaatt gtatcatggt cacctggtga 2006641 tattcttccg taaacacttc gatgatctca tcaatgtttt gattcaagat ccggctccac 2006701 tcataaaatt cctgaatgct gatgtcttga gaagaagctt cgctgaattt atgaatccat 2006761 tcaaacatga tgtgcctgaa agtgttaaac tggccgacac tttgtgtaac cgtcacttca 2006821 tgaacggcac ggtctctggc gcattgaaga gaccaccggt tgagctcatc ctctacgtct 2006881 tcttttctaa gggattttgc tacgatggtc accaataatt catgctggtc ttttaacttt 2006941 tgttctagtt tttgctgatc tttcgctgaa tacagccagc tgccgtttga cgtacaaact 2007001 tccagccatt gttgcgtaat atcttttttg tgctctgtta agtgctgatc aagagctatc 2007061 atcttaatga gttacctcct gtttttgaaa aatgtacgct atatatgtat aacgcgtctg 2007121 cctttacaca tactatgttt agattcaatg ggctatagcc aagcggtaag gcaatggact 2007181 ttgactccgt gatcgttggt tcgaatccag ctagcccagt ttctgaacag gtgaaaaacc 2007241 gaagataagc tgattcgtat aaatcagcgg atcttcggtt tttcatcatg cagattgatg 2007301 aaccgttttc ttcttcgata acttcaacag ttctcccggg ttataaccaa tcaccagctt 2007361 tttgttgtct actagaatcg ggcgtcgcaa aagcttcggc ttctcgatta aaagttccag 2007421 cacctcattt accgtcattt cttcaatgtt taaatttaaa tttttgaaag tctggcttct 2007481 tgtcgccaaa atttcatcaa ttccttctgt cgttaacgat aaaatgtact ttaattcttc 2007541 tcttgtcggg gtttctctga ataagtgccg ttcgttaaat tcaatttgat gtgctttaag 2007601 ccaatgtttt gtttttcggc atgacgtgca gcttggatat gagtaaaaag ttaattgttg 2007661 ttccattcgt tttttcctcc tcagttaacc atctctttgt agaataacta cccggatcat 2007721 ttttcattta aaccatttac agaacttttt tcggattatt ttttaaaaaa cattcataca 2007781 atagaaaaca caatcaaagg gacaaattcc atttgtatat taataatgaa aatgtttaca 2007841 tttctaggtg tgatctatta taataacagt cagagggact ctcgggaggg gataaaaatg 2007901 aatcgcatgt tccgggtgtt aggattttgg acgggaattt ttgcagtcat gttttattta 2007961 ggtgatatga aagatgcttc ccttttattt tttggacaga cgatcttatt tgtgtttcta 2008021 tcgtatttga acttaaccga acgcatgtat atttatattt ttggcgctta tttaacaatt 2008081 ttcttcgccg gctttacata ttactcaatt tttattatgg tgcccggcgg cggaggccat 2008141 taaatgcaga aagagacaaa ccttatcggt ttgtctcttt ttttacaatg aaaacccatt 2008201 taaaaacgga ttttgatcct gctcagtcag tacgtctgtt tcaggtccat ggccgcttaa 2008261 caccagcgtg tgttccggaa gcgtaagcag tttttcatga atggacgtca gcagcgtctc 2008321 ttgattgccg cctattaaat ccgtacgtcc tataccgcct tggaacaaga catctccgga 2008381 aatgaccaag tctgcatctt tcacgtagta agacacactg cctggtgaat gtcccggcgt 2008441 aaataatgtt tccaaatgaa acggcccgat attcaactca ccgtcgcctt caattagatg 2008501 atctgcaggc ttagctgtga cttctatccc tcgcagcatg ccggagccgt ttaaagaagc 2008561 gtccgcaagc caattttttt cattttgatg caggtaaaca gggatatccc atttttctct 2008621 cacttcatca agcgccccaa tatggtcaaa atgggcatgt gtaagcaaaa tggctaaagg 2008681 cgtcagccct ttttctttta tgtattgatt gattttatgt ccctcgccgc ccggatcaaa 2008741 aatcagacat tgatcatcac tgatgagaaa atatgcgttc gcttgaatcg gccctactgg 2008801 cattcgtctc catttcacta ttatcacctc tttctttttt atgctcttat tatgagggtt 2008861 tttgaaaaaa gattcaaaca atcgcaatga aaacgctatc gacaaaccta taaaaaacag 2008921 gtagaataaa actggaaaga attgcaggtt tttcaatgta aagggggctg tgttatgtta 2008981 cttgtcgtga ttttcggcct tgtcgctctt ttcgctttat ggggagtctt gcgttctgtt 2009041 agaaataaaa atatactcgg gtttttatta gccggtgcca ccttatttgt ctttggatgg 2009101 tttaccgtga tgaccgtaat aaacagcggg tatccaaccg cacattaaaa cctgtatccg 2009161 atcggataca ggtttatttt tatggctgta aatgtttatt gacactttct attttgctct 2009221 caagcgtcgt ttttttgtca cgcctgtcat cgatacggat attcgttgcc actctgtgca 2009281 atcctttttg aaatggcgct tcgtgaattg cctgaataac tgcaaaaagg tcactgagtt 2009341 ctccctcgat cagcgtattc atcggtgtca gctgatattt gattttccct tctgcttgat 2009401 atccttctaa tatcttttgc acatcggcta cgtaagcact gacactgggt gtttccgtac 2009461 cgattgggat aatggttaca tctgcgatag ccatcgttat tccatctcct tttgatcaat 2009521 gatgagttgc ttcgtttcat gtgatttcaa taaaataatt tgctcaaaat gaaagccgta 2009581 taacgcatat ttcccgttcg gagatatttg aatcggctcc atttcccgca gagacacaag 2009641 atcttttgtc tctcccgatg ctacattgat tgctgcgagc ttatatgcat cgccgctttg 2009701 tttgaatgta taaaacaggc ctcctgcttc atcatagtca tactccattg gagccaaact 2009761 tgtatatttc gcttggagcg gccatttcgc tgtaacaggt gatgttgatt gcggcgtttt 2009821 aaactgatac gtcccttttc ctccggaagc tgatttgaca gtaaaactca tttgatggaa 2009881 agaatcgaag aatagaacgt tatcctcaag cttctgttcc gtcttagaag ctgtatcgaa 2009941 cgtatataaa ggccctgttt tatcgtctct accctctttt acataatcaa atgtattttt 2010001 ggatgtccaa tgaatgaacg gaacctgtac tgggcttaag aaagattcgt cttttttagc 2010061 attcacctga tatgtatgga aatcccagtt ttcattgaat tccgtcacca tcatttgata 2010121 aggatcatac tgattccaag cagcttcaag ctcatacgtt tcgtaatctt tttcgtaaag 2010181 cgtctctcct tctgcattaa gcaaaaccac tgccgtcttt tggctatgtg tgatttgcag 2010241 cagaatcatc tgctccctcg cattgatttg aacatcaacg atttgaccat ccgtttgata 2010301 gagctttttc gctttgcctg taaagatgcg gtacgcaaaa agctctgttt tcgtcggatt 2010361 agacgcagta tataatattg tgctgttatt cagccagcct tccgccccat ccgctttttc 2010421 cgcggaaagc ggtatgatgt cttttttctc atcttttgcc gccgatgcct gtttttgctg 2010481 ctgatgagat ggttcgcatg ccgataaact aaacagcaat accgccagca gaataaaaca 2010541 aactgatctc atcagcattc ccctccgatc atctttattc tctcatattt gcttcggcag 2010601 aaaaaagaaa aagtttcagt tactcatgaa aaaataacgc cctccacaag ataccgcttg 2010661 tggcgttata tatgtgtgaa aactgctgaa acggcaaagg attttggcct tttccaagtt 2010721 ccaccgtata cccttcctta aaataatggt gaataaacca atcacgaaat ccagcatagc 2010781 tgtctatatc ccttactccc ttataaatgt tcccgcttaa ctcctcaaac tcctttatga 2010841 cggcagcaga ttcctcaggc tcaaggcctt tatagcccca ataaatttct tctccttgag 2010901 tatgaagagc cagcagtctg tcaggcggat tctccgtgat cagccggtac atcgcaatag 2010961 attccggctc cgtaagcgga gagattcccg gaaaatcgcg gtagctgggt gctgtcggtt 2011021 ttcggtattt ttcaatttcc cataatgatg gaaattgttt atttaaatca accccgttta 2011081 tattcgcctt ccattcatta aaatttggac gatgttcatt tagcctttcg agttcatctc 2011141 ttctggctcc catgacttct gatccgttta aaacaagatc aacgccatcc ggattgacaa 2011201 gaggaacgag ggataaggat gtgctgttaa acagctttat gggagaaaag ccaaagaaag 2011261 gcgaattgca gcataatgac atacagtatt ccttaaacca ttttagcagg acagacgttg 2011321 taatccactc attcgcatga aatgacgcgt tcatatggac cttttttacg gcatgctccc 2011381 caccagcctt cagctcccag ataggcctgc cgagtacaga acggccaatt tcccggcatg 2011441 agacaaacgg aaaaacatca ataatcttct ttatttcctt ttcaacagct gaatcatcat 2011501 agattttctc ttgctcaatc cagctatctg aaagtttcag ctgccgaggc tgtaaaaagc 2011561 gctttatgtc ctgaatggtt tgaagctctt tgccgctatg ctcctctatc acataaccag 2011621 ggcaatacaa ttgatgtttt tgtgcggagc gatttgcact tttaagcaat tcctcgtcta 2011681 tcttcagttc tttcgccaca ttggccaaat tgttcttgat ctcaggtttc accgtaataa 2011741 acgccatcat catccccctt ttttgttact atatgacagc gtatttaaaa aaagaaagcc 2011801 tcccgctcac ttcgatgcgg gagacattgt gattatgatg cctgatcaag catttgtttt 2011861 tctttccgct ttgacgaatt gtccagcctt ttctggtcat aaaatcgcaa caaatcccca 2011921 taaatgattt catcagaaag tgatagctcc tgttttgctt tatcagcaaa tgcttcacat 2011981 tgttttgtct cttctaacgg ttttcccgtc tctttgtcat aacacgcacc gtctgtataa 2012041 acaacctgat ctgtgataaa gctcccgtcc cggagcaccg tgaagtccag tttttcgtct 2012101 gaaagcagat cgttgccgaa ttgaatttga tctttcgtat caatccctaa aagattcatc 2012161 agcgtcggcc tgatatcaat ctgcccgcct actgtttcaa tggtttgcgg ctttttatca 2012221 gtaatacccg gaatatgaat gaccagcggc actttttgga gctgtacctc ttcaaatggg 2012281 gttatttctt ttcctaaaaa ctgccccatc gcttcattat ggttttctga tataccataa 2012341 tggtcaccat ataatacaat aacagagttg tcgtataacc cgtcttcctt cagcttttcg 2012401 ataaaccgtt tcagcgcctc atcctgataa cgcactgtcg gaaaatattt atttagcgtc 2012461 tggctgtttg aatcatattc atcaatcaat tgatcctctt catcaagatc aaacgggaag 2012521 tggttcgtca gtgtaatcag cctcgagtaa aacggctgag gcagattttt catcagctct 2012581 gaggactgct caaaaaattc tttatcctta agtccccagc cgactgaatt ttcgtcagtt 2012641 acatcatacg agttaatatc aaaaaacgaa tcatatccaa atgagtcgta cattaaatca 2012701 cgattccaaa agctcttatt attagcgtgg agcaccgctg aatagtatcc gctgtttttc 2012761 aaaatttcag gagcggccat atattgattg cccgcattcg taaaaaatac ggcacctcgt 2012821 ccaagcggat acagtgaatt gtccacgata aattcagaat ccgaggtttt cccctggcct 2012881 gtttggtggt aaacattatt aaagttgtag ctctgtttta taaagtcatt cagaaaaggc 2012941 gtgatttctt ctccattcaa tttttcatta atcacgaagc tttgcgtcga ctctaaggat 2013001 acgagaatga cgttccttcc ttttgcagcg ccgaataagc gtttgttggc atccttcgca 2013061 ttagcggtta cgtagttttc aatctccgtc aggctgttgc tgtctgccaa cgctctctgt 2013121 gcggattgct ttgactgaag aacgccatcg taaatatgaa aattaaacag gctaatgttt 2013181 ttaacaagca tttctctgtc aaatgagcgt gtcaatagct gaggtctttc cgcctcagac 2013241 aagcccaggt tgaagaaata aacagaagca acgaacaaaa aataagccgc ccgttcattt 2013301 ttcgttgagg gaatgtccga ttgaaaagct ttttgccgga tgtgaagcca tattaaaacc 2013361 gcaatatcta cagctaatag gaggtctgtc ggctcaagaa gtgttccgat gctgcttccg 2013421 agatcaccca tattgctcgt ttgaaaaaga acagggattg ttaagaaatc attgtaaaaa 2013481 cggtaaaaaa ccatatttgc cagcaataca aacgtgacaa gacagctcat cgcgataatg 2013541 tagcgatttc tgtttttgcc ttttaaaaac aggctgaggc caaaaataag caacaaaaaa 2013601 ctcaatgggt tgataaacag aataaattcc tgtgttagat tgtcgatttt aatatgaaaa 2013661 ctggttttgt aaacagcata cgttttcagc cacatcaata aaatggcaat cagcataaat 2013721 gaaatcttcg aaaaaaacgt ttttcgcatt tcaacctcct atgcagcacg ctcaaaaaaa 2013781 tcagtctatt cccaacattc tcattaacac atcaaattaa atcttaacct gagcacaaca 2013841 aaaaatcaat ttcatttaca caattttaac aattttgatg tttcagccat tcatttttag 2013901 cgatccaagc gcctccgata acgccggcat catttccaag tgctgcgatt gaaatatcag 2013961 cagcttgggc tgcccgcgga aacgcgcatt tgcggaatgt tttctcgact tttgatctca 2014021 gcagttctcc ggctctcgat acgccgccgc caagaacgat tttggatgga ttaagcgagc 2014081 ttgccaaatt tccgagcacc aaaccaagat gcttggctac ataatcaacc acctcaaggg 2014141 caatttcatc attttcaccc gccgcttcaa acacatctcg cgctgacaat tgttcggttg 2014201 cttttaaacg tgtcgtcttt ttagcatttg ctattttttc ttttgcaatt cttacaattc 2014261 cggttgctga cgcaattgtt tcgatacagc ccgttttgcc gcagttgcag ggcgctccgc 2014321 cttcagggat gctgcaaata tggccgattt ctccgccggc gccatttata ccatgtacaa 2014381 tttcaccatt tgcaatgatg ccgccgccaa ctcctgtgcc aagcgtcacg agaatgacgt 2014441 cttttgcgcc atcacccgct cccttccaca tttccccgag cgcagcaata ttcgcgtcat 2014501 tttctataac agctgggatg ccggtttctg tctccagatg gtttttcaaa gcataatttt 2014561 tccaccctag atttactgtt tcataaacca ctcctgccgc catatctaca gggcctggtg 2014621 cacccattcc gatgtatttg atgatgtgct tcggtttttg cagctcatcc agcttgctgt 2014681 cgattgtttt tgcaattgtg acagtaatcg tgtcgccggt tttatctgtc ggaacttccc 2014741 acttatgctg aatttcgcca tattgattaa taaaagcgag tttaatcgtc gttcctccca 2014801 ggtcaatgcc cgcaaaccat atctcgtcca tttttatcac cttagccttt ataaaaatct 2014861 cttccgtttt ttgtttgttc caattctttt cgaaggacag ctgccgctct ggcccactgc 2014921 tccttttcaa tcatgtggtt catgtataat tcctttaatt catccagcat aaactcaatt 2014981 tcaagctctc tgtctccaaa ataaacaatg tggccaaacg tttttaacag ctgctgcaca 2015041 tcataaaatg tattcatttt cctcaccatt tcttgaactt aactatcata agcgtattca 2015101 taaggaagcg gtcagtcaag aagaaaacgc tgacaaaaaa gccagcttcc tttccatatt 2015161 ccacctctat gattctttat tgttttcaat ttgccgctgc agctccttgt agcgctgctc 2015221 cttcggcttc agtttcacag ccgtctggat ggccttttct gcttgtgcaa gctcattttt 2015281 ttccgcatac aataacgcta aattgtaata ggaagcatgg tctttaggtt cttttttcac 2015341 tgctcgttcc aaaagggaaa ccgcctgatc atattcgccg atttgaatat cagaaacagc 2015401 aagaattttc aaaagatcgg cagaggcatc tttttgcgct gcttctccgt tcagcaattc 2015461 tgttacttct tcatactttc cttcctgata cagctcgctt gcctgctgaa tcagcgctga 2015521 ctcctggtgt gaaggcgaat gcaatccgta atataaaaat ccaacagcca aagcaatcag 2015581 caaaaccgct gacaacaatc tttttccaaa ggctccggct ttaggcaacc ccagtgctgc 2015641 tgcagcgaaa aagccgccaa tcaagccgcc gatatgtcct gaattatcaa tattcgaaac 2015701 cgcaaaacca aagcccagat tgatgataat aatgacaata atattggttc ctatagttct 2015761 taaaaacatt tttcgattag acaaagcaac atacagtaat gcacctaagc atccgaatat 2015821 ggctcctgat gcccctgccg aaggatacgg gctgaacaca aaactcgcaa tcgaacccgt 2015881 aatgccagca gccagataaa tcagcaaaaa tctccccgat ccatacatcc gctcaaccgc 2015941 tgtaccaacc gaccataaag ccagcgtatt aaaagctaaa tgcgctatgc cgatgtgaag 2016001 cacgatcggt gtcagaagcc gccaccattc tccttgtgca atcaggctgt tttcttttgc 2016061 tccaaaagcc accagtgtct ccgtattagt gctgcctccg tttatttcga gcaagaaaaa 2016121 catcaggatc tgaagcgcaa taaataaata tgtaaaagtc ggttttccgt tttgaaaaac 2016181 cgccgcttca gtttttctct gttcttcttg tttcagcact agcgaaagga agcgttctcg 2016241 cgccatttgc gcgttttcaa acgaagcgtg ttcctctgaa caatcttctg tacgaaatga 2016301 tggaaaaacc gcttgaagat catctcgaag catcgttcct ctaacgatcg ccggctcaac 2016361 tgacacagtt cccttctcaa aagttttttt tgcaatctct tcccagtcat caactggggc 2016421 ttccgttgaa aaaaacacgt tcagcagctt catccttcgt ctgcccaatt gatgtctgac 2016481 tcgttctact cgttcggcct gctcttcgat gtctctaacc atttcttgac ggaaatcaag 2016541 atcgtgctta taaagacgaa ctagatcatg agaggacttg tccggcgctt ccagccatat 2016601 ttcatctgac tcaccggctt gtatgacgcc atacccgcta ttcaccaggt gcgccgcaat 2016661 tttccaatat gtatactcca gcaaaaacat gtttaccgct ccaatagttt tttttcatta 2016721 taacagctgg cgctccgaaa cgcctactga aagcaaaaaa tcccgttttt cacgggattt 2016781 tagaaagctt gctgtataaa cttattgcgg ataaatggaa ttcttaaaaa caaatggata 2016841 aaagaccgcc tgattcctgg ctggctgagt acagtattca taagacggta gcgattttga 2016901 taaaacatga cggcagaaac cgcgaaaatg gcatatatca aaagtttttt catgatatcc 2016961 ctcctgccaa tagggtttgt tattctacct tatttattct cgaataaggg acaggaaagt 2017021 tatgaaaaac aagaaataat ccgatcctct gttatcagct tatgtaccgg gatgtcatgc 2017081 ggcagacggg gtacgtgcgc aaacaactgg cactccaaaa gcaaagagac tgtcttccct 2017141 tcatattcac ttaaatagcg atcataatag ccgcctccaa agccgaccct aaacccgtta 2017201 acatcaaaac aaacacccgg aacgatcatc aagtcaattt gtgatgggtt tacttctttt 2017261 gttttttcaa ttaccggctc gagcagtccg gcgtacacgg tttcgagctg atcatcagtc 2017321 tgatatgtgc gaaattgcat tttcttcgtg tccggatggc attttgggat gcaaacttgt 2017381 ttcccttctt cccaagcctg ctcaatgaca ggacgcgtcg gtatctctaa tcctctggaa 2017441 atagtgacgg caatggtgcc ggcattttgc cactccggca gagaaaacaa gtacttatac 2017501 atacgttccg ttttttgaag aatatcttca tttgataaag cagacagtgc ctccagcgtc 2017561 ttttttctta attgtgattt catctctcat ccccctcgga atagaaaaaa agccagaacc 2017621 tttttcaaag ctctggcttt tttcttacac ctcaaacagc aaagctgtta ttttgtttca 2017681 cggtgtaacg tagatttttt atcacgtggg caatattttt taaattcaac gcggtctgga 2017741 ttgttgcgtt tgttcttttt agaaatatag ttacgctcac cacattcagt gcaagccaaa 2017801 gtaatattaa cgcgcattat tttccctcca aactaaaatc atttacttat tcagacttat 2017861 atataatacc actataatgg acggaatgct aggctgtttt tcaatgaatt gctgaattat 2017921 tgaagatacg ctcataaagc tgcaaatatg atgacataat gagtcggggg tggtggagct 2017981 tgaacacttg ttgtctgcca gcttctttta tccggcgggc tttttcccgg tcttttaaaa 2018041 aactgtccag cagatcagca gcttcctgta cgagcgtaaa atcagcgatg attgccgttt 2018101 tgtcatgaac cgcataatca caaaaaccac ctgactgaga aacgacagtc agcacacctt 2018161 gttccatgct ttcttgcgcg gcaagcccaa acggttcata agaactaggg aaaacagcca 2018221 tttcacagtg agacagtaac gttctgatat ctttcctatt tagaaacggc agaaacatga 2018281 cgcgatcctt caggttatat gccgcagcca atttctcata gcaggacaga gacggcccct 2018341 ccccagccag cactagatag aggtcaggct gacgctgctt caagatggca aacaccttta 2018401 acagctgcga taatcctttt tccggaacaa accttccata tgaaaagagg aatcttctat 2018461 tcatgcttct cgggattttc cccttctctt cctccataga tgcagggctt gggataacgg 2018521 ttattttctt atgtgccgcc ttatcaagag accgcttcat aaatgtgctt aatacgatca 2018581 atgcatcagc ggattctata aggagccgtt cggtcatgag cctgtatggg tgtggggctt 2018641 ctcggcacac cttcttcctt tcgctttcaa gaccgtggat tgtcgcagca agcggaaggc 2018701 caagccgttg tttcaaatac tgggcggcag gggcagttgt gtcatcatgg gcatgaatca 2018761 gatcaaagcg tttattgtgt gataacacat ggcgaaccat tgtaaagtta gcatcagcta 2018821 tgtaatcttc aaacttcgca tacgaaaaca gctgcccgct cggagtaaaa accgtaatgt 2018881 tgatatgagg gtttaaatag gaaatgaggc ggtttaaatg gacaccgagc ccgcttttcg 2018941 gctcatcggg atgttcgggt gaaagcatga gaatgttcac cgttcttttt cccctctccc 2019001 ataacaggtg tatgcagaaa attgcgcctc ccacctggtg tgcgcttctt caatctgaaa 2019061 actgtttata tgacgaatcc cattttcatc aagatagatg tcgtctgtac cggcaagctt 2019121 gagagagaca ttcattgaat tcacaattct gtattcagcc cgatatacag catcaccagc 2019181 cgcctgtcta atcgtccatt ctcctttatc atacgttgtg cgttttgtcc tgacagcttc 2019241 aatgtctttt cttttgatga caatgcgcaa ttcttttatc atatcctgcg ttttttcgaa 2019301 aaggaccgct tcagccagcc gcattgtttc ttctgagatt tcccagctta cggtcaaggt 2019361 gtgagcgttt tgaatgatta tgtcgaatgt gtccctaaaa aaggaaagct tatgtcgtat 2019421 attataggga aatgggtgtt tatccatgga ctcctaacat tctcctttcc aatcgttcac 2019481 ttcgtgttcc tattaaacca ttacatgaag aagaagcgaa gaaagatttc tcgacaaaat 2019541 ctcgtttttt tcgcgaattc ctttagaaac tattggtttt atggtataaa aaagaaggat 2019601 aaaaaaagaa tagaaggtga tgaaacgtgg aaattgctat tattgcgttg tttatcgtca 2019661 gtatagcgct aattgcattc tcatattctc aaagagaccc gatgaaagat gtagaacagg 2019721 agctcgaaac actgcagctt tctgcgatgc aggaaattta caagctcaaa aagaaaatga 2019781 cagtgcttga ggaagaatta ctggaaacaa accttgtcat tcgcaaatca aagcagaacg 2019841 acatcaatca aaaaatcgct aaacaaatac tttctaaata taataacggt atgtcagctg 2019901 aagcgattgc taaagctgaa catgtatcag tggaagacgt gaatacgatt atcaaagata 2019961 atgagaaggt gctcgtatga caaaacgggg cattcaggca tttgctggcg gcatcatttt 2020021 agcgacagcc gttcttgcag ctgtttttta tctgactgac gaagaccagg ccgctgctgt 2020081 aaaagataat aaaacagtaa ccgaacaaga cgtgaacaat tatcttgatt ctaaaaaatt 2020141 ggtttctgtc aaccgtgatg aatatcaaaa acttctcgat tcaaaagaga aatccttaaa 2020201 caatgacagc ggctcagaca cgaaatcaga caaagtcaaa acctacaagc tcaccattaa 2020261 agacggcatg agcacggcgg atgtatctgc tattcttgaa aaagagggca ttatctcttc 2020321 ggctcaagac tttaatgact atgtcattga tgccggctat cacaaagaaa ttcgtgccgg 2020381 cgagtttaaa gtaaaatcag acatgagttt caaaaagatc gtaaaaacgt taacacgata 2020441 aaaaaacagg ctgactcagc ctgttttttt catccaaact ttcctgaaat gtaatcgagc 2020501 gttctttggt ccttcgggtt agagaacatt ttattcgtat tgtcgcattc aacaagctcg 2020561 cccatgtaga aaaaggcggt ttgatcagaa acccttgctg cctgctgcat gttatgcgtg 2020621 acaatgacaa ttgtatattt atctttcagc tctagaatga gttcttcaat ttttctcgtt 2020681 gagattggat ctagtgcaga tgtcggttca tccatcagca aaatatcagg attggtcgca 2020741 agtgctctgg cgatgcaaag acgctgctgc tggccccctg acagcgaaag agcggacgta 2020801 tgcaatcgat ccttcacctc atcccataac gccacgtctt ttaatgactt ttccacaatt 2020861 tcctgaagct tcttcttatt tttggtgccg tggactctcg gtccgtaagc cacattatca 2020921 aaaatagatt gcggaaacgg attccctttt tggaatacca tgccgatatt ttttcgcaaa 2020981 tccacgatgt ccactttatc ctttaaaatg ttgctgccat tatagttcag ctcacctgca 2021041 agctttacat tcggcgtcat ttgaatcatt aaattcaatg tcttgataaa ggtcgatttc 2021101 ccgcatccgg atggtccgat aatcgccgta acctcatttt cataaatgct caaattgata 2021161 ttttttaaag catgatgctg cccataccat aagttcattc cattgacttg atatacttcc 2021221 tgtttcatta cagcttcggt agcaatactc attgccgccc tcctatccga atttcccgtt 2021281 aatataatcc tctgtctttt gctttttcgg actcgtgaaa atctgttcgg tctgtccgta 2021341 ttctacaagc tcgccgttta aaaagaatgc cgtccggtca gaaacccgca gagcctgctg 2021401 catattgtgc gtgacaataa taattgagta ttctcttttc aatcctgtaa ttaattcctc 2021461 tatttttgca tttgaaatcg gatcaagcgc tgaagctggt tcatcaagca gaagaacagc 2021521 cggcttcatc gcaagcgttc tcgcgatgca taaacgctgc tgctggccgc cggataacga 2021581 gagtgcggat gaatgtaaac gatccttcac ctcatcccag agcgctgctt ttgttaaact 2021641 ttcttccaca atttcatcta aaacagcttt attccgctct ccggcatatt tcaatgcatg 2021701 tgtgatattc gcatagatcg atttcggaaa tggatttggt ttttggaaaa ccattccgat 2021761 ttctcttctc aagctgacaa cgttaatatt gccgcccaat atatttaatc cctcataaag 2021821 gatttcacct tccgctcttg cagatggaat taaatcgttc attcggttaa tatttctcaa 2021881 aaaagtagat tttccgcatc ccgacggccc aattaaagca gtcaccgcat ttttttcaat 2021941 atccatgttt acatgatgaa cggcttgttt atttccgtaa taaatggaca gatctttgac 2022001 ctcaagcacg tggttctgct tcggaacaat aacagctcgc tcaggttttt cttttaccat 2022061 ttgttcagac atgtttttcg cctctttccg ttctaatttg ccgtaagctt tttgtagatc 2022121 atcgtgccaa gccatctcgc cgcgagatta aacacaagaa cagaaatcac cagcacggca 2022181 gaaccaccgt tggcaatcgc ttcagcatcc ggaatcattc cttgtgtatt gacgttccaa 2022241 atgtggaccg caagtgtttc agcgggcctg aaaatattaa gcggtgatgt ttccgaaaac 2022301 gggttccact ccgtaaaatt aagacgcggt gttgtcaggc ctgccgtaaa taataatgcg 2022361 gccgcttccc cgaacaccct tcctgacgct aaaattgctc ctgtgatgat agaaggaatc 2022421 gcacttggaa ttaaaactgt ttttacggta tgccagcgtg atacacctaa agcgagagag 2022481 gcttccttca gatctttagg gactgaacgg atcgcgtctt ctgtcacacg caccatgaca 2022541 ggaaggttaa aaacagttaa cgcaagcgct ccgcctatga tcgtataacc ccagcctgtt 2022601 aagttgacaa acatcaataa tccaaacatc ccaatgacaa tagacggaag agatgaaagc 2022661 acctctatac atgttctaat gaagtcagtt actttgttat taggcgcgta ttcagccatg 2022721 aagactccgc cgcccacacc gagcgggatt gtaatcagca ttgtaataaa caaaatataa 2022781 aaggagttaa acagctgatc tcgtatgcct cctccagctg caatggcgct cgactttgtt 2022841 gtaataaatt gaaaactgag ctgagaaaca ccgtttataa taatatagga aaacaaacct 2022901 actaaaatgg cagcgataat ggctgcacac aaaccaaaca ttccggtcgc cagtttatct 2022961 gttattttgc ggttcattac actttcctcc tagatgacaa gtagcgaata agcaggatga 2023021 acaagaatga catcaccaga agcacaagcc ccattgacca cagcgtattg ttttcaacac 2023081 ttccgtatgt ggtgtggccc atattcagcg tgatgatcgt tgtcagcgtt cccgcagtgt 2023141 caaacgggct ttccggcaat actcttgtat ttccaatgac catctgaaca gccaaagctt 2023201 caccgaacgc ccgagccatg cctaacacaa cagctgtcat caatgttgga aaagctgcag 2023261 gcacaagtac ttttctgatc gtctgccatc ttgtggcacc aagcgcgtaa gaaccctctc 2023321 gtaaactctt cggaagagaa gccattgcat cagcagaaat cgatgtgatc gtcggcagaa 2023381 tcatgacgga aaggacaatc gttcccgcca ataaactgtg ccctgttccg ctcgatttga 2023441 actgggcgat aaacggcacc aatactgtaa gacctatgaa tccataaaca acagatggaa 2023501 taccgactaa aagctcaatc accggctgca gcactttctt tccccaattc ggggcaatct 2023561 ctgtcataaa aatcgcacct gcaatgccaa gcggcgcagc gattagagca gaaagaatcg 2023621 ttactgcaaa tgagccaaaa ataaatggca gcactccgta tttcggatca ctatctgtag 2023681 gattccaatt taagctcgtt aagaattcaa ttgggcttac accatttaca agaaaagatt 2023741 gcagcccctt aacgccgagg aaaatggtaa tcgcaacaga tgccgcaatc ataatcagtg 2023801 cacaagctgt gactatcatt cttccccgaa cttcatccaa ttgccgattt tgcctagagc 2023861 tgattaagcg ctcgctcaca gacatatttt ctctattgtt tatcattgtt ttacactcct 2023921 atgaatgtgt taagaggaga aacggttgtc cccgcactcc tctttttatt aagatcagct 2023981 ttgcttcccg ttggcatcac gtgtcacttt catatcagta accggaatgt agccttggtc 2024041 agtaacaatg cttttttgaa tgtcttcact ctttagataa tcaagaaatt ctttagctaa 2024101 acctgtcgct tcaccttttg tataagaatg ttgataagcc cagatcggat actcgccagt 2024161 tgctacattt ttcgcttcag gtttaacacc gtcaatagat agagcagtta ctttgtcatc 2024221 tgttaaatat gagaatgcaa gatatccaat cgctcccgga gtatcagcaa tgatcttttt 2024281 caccgtgttg gaggaatctt cagtaatgcc ttctgcaggc tccgctccgt caagcgcata 2024341 tttcacaaat gtagcacgtg tgccggaaga atcagggcgg tttacaagtg taatcttttg 2024401 gtctttgccg ccgagctctt tccagttttt gattttgcca gtgaagattt ttttcaattc 2024461 atcttttgaa atatccttta caccagcatc agggtttaca gctgctgcca taccaactac 2024521 agcgacttga tgatcgacaa gcgcttttgc atcgatgcct tctttttctt cagcaaaaac 2024581 gtctgaattc ccgatctgaa cagctccttc agagacttga gaaagccctg ttccagaacc 2024641 gccagcttgt acctgtatat cagcatcagg gttttcttcc ataaattttt ccgcggctgc 2024701 aagtactagt ggctgcattg ccgatgaacc agaaatggtt aaagaacctg atgccttttc 2024761 ttctcctttt gcagaatcgc tattcgattt tttactttct cctgcatttc cgcatgcagc 2024821 tgcaatcatc ataaaagcag ccatcagaag cataagcacc aatttgtttt ttttcatttc 2024881 ctgaattccc cctgcgtata atgtgtaatt tgtcctacac gtatagagta aaggttctat 2024941 gtaaaaaggg tttgaaccga atgttaaggt tttgtaaatc agtgcgtttt tttgtataaa 2025001 aaaaacgccc acatcatgtg agcgtttttt tttagttatc agaagacgtt gtgttttctg 2025061 cattttcttc aattttgtct ttattctttt gctgagtacc ttctttgtcc tgcttcgatt 2025121 tcagctcaaa atatttatcc attacttccc tgccgatttc gtttgtaatt gagtatcttt 2025181 gattgtaatc aatgtaagtc caaggaacta cgacagaaat agcaatctca ggattgtcag 2025241 ctggtgcata agccacaagc gtcgtattat aagtgtctgt tcctgttttt gatttatccg 2025301 gtccgtcgta aaatgattgg gctgttcctg tttttgcagc tggtttatac gatgctgaag 2025361 ccagttgacc tgcagctgtc cctttagtgg caacccgtct aaaaccggct tggacctctt 2025421 caatatagct actcttcata tcgactttat tcaatacttc aggctgaaca gaatcaacga 2025481 ctgcgccgat cccttttttc gcatttgaat ctctgacttc ctttacaagc tgaggcttca 2025541 tgcggtagcc accatttgct atggtggaga catattgagc caattccagc ggtgtataag 2025601 tatcatactg tccaatggcg aaatcaagca agaaaccaga taatctgctt gtacctttat 2025661 atcccgtcat ttcatttggt agatcaattc ctgtttttac tcctaatcca aattgactga 2025721 aataatttct gaaggtatca aatgcagaag tatccaaagg caatgcttgg tgaggtttat 2025781 attcaccttt accaactgca attgctgttt taaacataaa aacgtttgat gacttctcta 2025841 atgcagtttg aataccaacc ggccctaagt tttgccaaga ttttttccct cttttatcct 2025901 ggccgatata caatggttca tccttaaata cagtattcaa attaatcgct ccagtttgaa 2025961 gaccggtcaa aacggttgca ccttttacag ctgatcccat agcgtaggat gaagtcatgg 2026021 ctcctaatgc ataatcatca aacttatagg ctccattttc tcgtttaatc tgcttccctg 2026081 ccattgtcag cacttcgccg tttctagggt ccatcatgac aacgaatgca cgatccaaca 2026141 attcggtact aggtcttgct ttagcagctt taagtttttt ctcaataatt ttttccactg 2026201 atttttgcaa atcaatatca attgttagta caagatcttt cccggctttg ccttcagata 2026261 ccgtttttgt tcccgtgaca ttgccttttg aatctgtgat attttcgact tttgcttttt 2026321 ggccctgcag aaggctttca tattggtatt ccagatagct ttttccgacc ctgtcatttc 2026381 ggctgtagcc aagcgacaga taatggtcga gcaagttgga cggcaatcct tcattagagc 2026441 tggaaacact tccgagcact gagcgaagaa ggtttttata aggatattca cgttcccaat 2026501 cggacgtgac atcaacacct ggcagttcgt ctaaatgttc acttaccact gccatttcct 2026561 tcgctgatac atcttcgttt ttgatatatt gaggggtcaa tgcatagccc gaatccatct 2026621 gtcttttgat agcaaggatc tgcatatctt tatccgtcaa ttcattcagc tgcttatcag 2026681 taatccgttt tagctgaagc tggtataaat cgtcatcgga tatttttttg tcttcaacct 2026741 gctgtctttc tttagagcta atgagctttt tcgcttcttt cggtctagtc aaaatccaat 2026801 aatctttttt atcccgttct gttacttttt ttgtatcgac tttgatcatg tcagacagct 2026861 tttttgcgat ctttaagcgc tgttcttgcg tggtcgattt agatctcgtg tatgtgattg 2026921 catttaaagc cttatttgtc acaatggcat taaagtttcg atcataaatt ttcccgcgtg 2026981 gtaccgctga gctgacttca ctttgttcct gcttattcgc ttggtttttg taatcatcac 2027041 cttgcacgat ctgcttgatg cccagttcca caataatcca ggtaaatata acaaaggcag 2027101 ctaaaaataa aatattcagc cggatcggaa gcgacttctt tttctcttta tgattttgct 2027161 tttttggttt atttctcctc ataacatcac cttttctatt tacagaaaga aaagacactc 2027221 aagtaagagt gccagttttc attttaaagg ttttttcgac ttttttctac agataacccc 2027281 tttttggcaa aaaaattatc tctcgccttt taaaagggtc ggttctgtta cccgtttttg 2027341 gccgtcttct tccatggttt cattttcccc ttctttctcc ttaaaacgaa tatccttgac 2027401 aaagtaataa atcaaaggat gtcctatacc caatatcgca agtgacaaag gaattcccac 2027461 atcctctttc agaagggcca caatcaggag aaagcacaaa atggaaacaa ttctgccggc 2027521 gttcaagaac atttctctaa gcacgatata ttcaattctt gcttttctgg catgcctcgc 2027581 gcgccctatc acatcatatg taagtgatac atatggcaca agcaacagag gatagccgat 2027641 ggcaataaaa acgccgtacg ttaataatgt cgaaaagctc atatggaaca gaatcaaaaa 2027701 cagcgcgcca tacaaaataa gtccgcccag caaaatcgat ttttttctcg cctttttctt 2027761 aatcagcctg gatgcaaagt agtaggcaaa gaaggaaaca gctgaattga caagaccgaa 2027821 tgtaccgaga gcaagctcgc tgtttgtctc aataaataca aacacactga ttaaaaagac 2027881 aaaaatccct tctctcaaac cctgaaaaaa atgcgcattc gtgattctcc gccaattcat 2027941 attgctatgg cgctctccaa atactttgct cagcataaaa cggccctttg attctctccg 2028001 ttttaagaaa aagctcatca cgacagccag ggcaaataaa ctgagggaga gactgaaaat 2028061 cactgtataa cccgtattat tttcaagcct tgagatcacg aatccggcta caatcgggcc 2028121 gatcattcct gcagaggaag acagaatgcc cataaacccg ttgaaaaagt ctcgtgtatc 2028181 cggctctgtt atttcaaagg tcagcacgtt aaacgctagc caataaaagc catagccaac 2028241 tccgagcacc gcgccgatta gcacgaggcg gctggccgcc gtttctccgg ctaaaagcac 2028301 acttaaataa aaggcagcta aaaaaatgac gccgaacctt aaaatgaata ccctgtctat 2028361 ttttttggct aaccgtccag ccaaataaaa ggttatcggc tgcattgtca caatggataa 2028421 attatatatc gccaaatcaa taaatttccc tgactgcttc caaagataca cattaacaaa 2028481 tgtattggac agtgcaattc ccagcgagta aagcccgcca atggtcagca gaaagagtaa 2028541 gcctttgttt acgtctacat cgcctatcac tttttttagt ttgctcatta ctgactcccc 2028601 tttactatcc cttagtctgt ctcactcaaa ccgagatatg taaaaagaag acataaaaaa 2028661 acaaggtccc ataatgagga ccttgtttgt gccattattt tgcttcgctg tatagacgag 2028721 ccacttcgtc ccagtttaca acattccaga aagctgaaat gtaatcagga cggcggtttt 2028781 gatagttaag gtagtaagca tgctcccaaa cgtcaagacc taagataggc gttttgcctt 2028841 ctgaaagcgg agaatcttgg tttggcgtgc ttgtgatttc aagtttaccg ttgttcacaa 2028901 caagccatgc ccagccagaa ccgaagcgtc cagctgctgc tgctgcgaat tgctctttga 2028961 atttgtcaaa gcttccaaat acactgttaa tctcttcagc aagcgcgcca gtcggttcgc 2029021 ctccgccgtt tggagataaa agtgtccaga ataatttgtg gttcgcgtgt ccgccgccgt 2029081 tgttgcggac tgcagtgcgg atgttttcag gaacagaatc aagatctgca acaagctctt 2029141 caactgattt gttggcaaga gcagtgtttc cttcaaccgc tttgtttaaa tttgtcacgt 2029201 atgtgttgtg gtgtttcgta tggtgaatag tcatagtttc cttgtcgata tgcggttcta 2029261 aagcatcgta cgcataaggt aattctggaa gttcgtaagc catgataatt cctccttagt 2029321 atatatgtac tgaaatgccg cttcacagcg agcctttctt cattcaatgt aacaaaagaa 2029381 tgctttgtaa tcaatgaaaa agctcacgat ttggctcatt tcagcggaca tatttcactt 2029441 taaccgataa tctgccccat taaacctgcc gccagcattt cttataggac cgtccataaa 2029501 aagtaaccga tcatcaaaag ctgtatgatg ccctttgcaa taacccctgt taaaaaacca 2029561 atgagtgagc cgaggccaat tttaaacgct gactttaagt ccttctgatg gacgataagt 2029621 tctgcgcaaa cagccccgat aaacggcccc aatatgatcc ctgcaaccgg aatgacaaaa 2029681 ggcccgatta ataaaccgat cgtgcttccc catatggcag ctttgcttcc tccgaacctt 2029741 tttactccaa gcagattcga cacgtaatct gctgcgaata atactgcggc aaaaactgcc 2029801 tcaacaagcc agaacatata agaatacgga ctgaatgaaa ataaaaatcc gtacaataca 2029861 aatccggcaa caataaatac tacgctagga ataacaggat acaccagccc gataaaggca 2029921 atgataaaaa ccgctgcaat caacagccaa tacaacatat ccatagcttc catcctccca 2029981 ttttactctg tcttcttcat gtcttccttg tattcacacg catgcaacga tacaataagc 2030041 aacatatatt agtttagcta ggaagtgaag atagtgaatg tgtttcagct tttcattaaa 2030101 agtacatact ctccccgtga tattgcaaaa acaagatttc aaggaatcgg aaaagcgatt 2030161 ctttatgtat ttttgctctc tgtcctgttt gcaatcccta ccgcttatta tgtaagtaca 2030221 gggaccgtaa aatcaatgaa cggctttaaa actgttttaa acaaagattt ccctgatttc 2030281 acaatttcaa acggcaaact tcaaacggat gagaaaaaag ccacggaatc tcaggcaaat 2030341 ggtttcgtta tcgtgttcga tccgacagac tcctatggca ctgaacaaat tgaagcaaag 2030401 caaaacgcaa tcggcatcct tcagaacaaa tttgttttgg ccattgacgg acaagcccaa 2030461 gaaatgtctt actcaatgat gccgtcagag ttacagaaaa aagatgtcat tgcaggttta 2030521 aaccaaaata aagcgatgat tgtaactgtt ctctcagctc ttatttttct cgtaacagca 2030581 gcgggaaaat ttattgaagt atcgttttta gcgcttatcg ggttaatcat taagaattcg 2030641 cagaaaaaac atttatccta tcatcagctc tggaagcttt ctgcttattc catcacactt 2030701 tcaactgtat tctttacaat catgcgggca ctagaagcaa ccgtaccaag tgaatttttg 2030761 ctgaactggt ttgtcaattt tgtcatcctg tttctcgttt taaaagagat tccgtccaaa 2030821 aaagtaatta ataaaagtta aattatattt atttttatcc tttaagtaga gagtgtgaaa 2030881 gcatttgcat taacttttta cttaagggat atttaataaa atgtatagag cttaaacaga 2030941 tacatttata aaaaaagctc tacaattact caagaacaag ctctggacaa taatatcaga 2031001 agtagtaaga tgtaacatga aagaagttct taacagcatt tgacatatgt ttttaacaaa 2031061 ataagaataa tgttaaattt taactaatag actagttaaa atcatatggc aaaatatttt 2031121 gcatcctttc acaacatatt tacataagat agttgctatt taaaaagcca ggtaccaata 2031181 gggcacctag ctttcagaat taaatcatca acaagttaga attatcttct ttccttctat 2031241 tctcattatt gaactgttat cttttttgtg ggtttatgta tacaaatgca gctcccttag 2031301 ctttcccctt atatactgat aaacctactg cccaaggtgt tcctgtcggt tttggtaatt 2031361 tactgaagta aaactttttg gttggagttc tacttgaaaa gtaccctgaa tattgcgggc 2031421 caatgtcccc accctcaact atagatacac caaagctctt ataatttagt ttaccgcatt 2031481 ttccatttgt ttcggcgtaa gcatcaatag atgttgcact cttagtatat gtataagcat 2031541 ctgtaataac tcttatttta caaccagaaa taccacttac cggttgccaa ccactgcttg 2031601 cagcctctgc tttttcttta ggtgcaacta ccaaagttaa cattagtagc aaaattaaaa 2031661 acacagaaaa ttttccttgc ttcattttgt agatcctcct ttaaactatt acataattat 2031721 cctaacagat ccattgttca ttgtaaataa tggaatacga gttttatatt ataaaagcct 2031781 ctttttgatc taattttgca ctattttcta ttttctatct gaagttaatg tttagtcgaa 2031841 gaaatcctgt caaaaaagcg cctgtataaa aaccgagcat tcgcagtctc ttttcttttg 2031901 tcatgaatcg aaatggacaa gcatactatg gtataaaatt tcgtatgcgg gaggaaaagc 2031961 gatgaagcgt ctcaccttag tatgcagcat tgtttttata ctttttattc ttttttatga 2032021 ccttaaaatt ggaaccatac ccattcagga cctccctgtc tatgaagcat cagcaaaaac 2032081 ggctgtacaa gaaccggctt ataaaacggt gaaggtaaag ccgggtgata cggttatgtc 2032141 gatagtcgga tcagcaggtt ctccggatga cattgtaaag gattttgaag cactgaatcc 2032201 aaatgtgaaa gctaacgcca ttcaagccgg aacagcgtat aaattcccgg tctaccctta 2032261 atttaacgtt aatttcttgt cagttcggcg aagacactgt tacaatgtaa tttgtaaaat 2032321 aaattcacat aaaccatact agaattgtta tatctagaag cggcaactac aattaaggag 2032381 cgattgcaag tgagtgaaat cacacatcgt acaaaaacgc gtcccgtcaa agtgggacct 2032441 ttaacaatag gcggcaacaa tgaagttgtc atccaaagca tgacaacaac aaaaacacat 2032501 gatgtagaag caacggttgc ggaaattaac cgtttggctg aagccggatg ccaaatcgtt 2032561 cgggtagcat gtccggatga acgggcggca aacgccattg cggatattaa aaagcgcatt 2032621 tccattcctc tcgttgttga catacatttc gattataaac ttgcgttgaa agccattgaa 2032681 ggcggcgcag ataaaatccg aatcaacccc ggcaatatcg gccggcgcga aaaagttgaa 2032741 gcggttgtta aagcggccaa agacaaaggc attccgatca gaatcggagt aaacgccggt 2032801 tcattggaaa aacggatttt agaaaaatac ggttatccga ctgccgatgg aatggtagaa 2032861 agcgcacttc atcacattaa aattcttgag gatcttgatt ttcacgatat tattgtcagc 2032921 atgaaggcct ctgacgtgaa ccttgcaatc gaggcttatg aaaaagcagc gaaagcgttt 2032981 gactacccgc ttcacctcgg gatcaccgag tcaggaacac tgtttgccgg cacagtaaag 2033041 agcgcagcag gactcggcgc cattttaagc aaaggcatcg ggaacaccat gcgcatttca 2033101 ctaagcgcag accctgtaga agaggtaaaa gtagcaaggg agcttctgaa atctttcggc 2033161 ttagcctcca atgctgccac gctcatctca tgcccgactt gcggccgtat tgagattgat 2033221 ctaatcagca ttgccaatga agtggaagag tatatttcta agataaaagc gccgattaaa 2033281 gttgctgttc tcggctgcgc tgtaaacgga cctggtgaag cgagagaagc tgatatcgga 2033341 atcgccggcg cacgcggtga agggctgctg ttccggaaag ggaaaattgt ccgtaaggtt 2033401 ccagaggaaa cgatggtaga agaactcaaa aaagaaattg acattcttgc tgaggaacac 2033461 tacgcaaaac ttgaagctga aaaagcaaaa ttaaaagaag aaacacaaaa agcttgacgg 2033521 gaacccgtca agcttttttg tgttagaaaa atggaataat aaatattcca agcactaatg 2033581 aaacgacacc gatacccatt gcccaggctc caaggccttg agcacctctt cttcttgcga 2033641 tatagccgac aataatacca gcagctccca ataaaacagg cagtacaaac aatgaaatga 2033701 tggacaaggc taaagcgatg taccctattc cccgtccttc attgacattg ccgccgctgc 2033761 gatcattgtc ttggtcattg ctgcggtcag cagcacgata aggctctgcg atttcagcag 2033821 ctgtttcctc aaaaaaaccg tcattgtcgc gggtaatatt tgtcccttca gatccatgat 2033881 caacatagta actgttgtta tcacgctttt cgtaatcgtt tgccaccttc aattccccct 2033941 tctgttttat taaaggagct tttatagttt gatccatttt gcctgattca tgtttgctaa 2034001 acttttctgt taatgtcaat tgtttatgtt acacttgaag ggatgaaact gaaggagtgt 2034061 gggcatgtta cgcttaggaa tagatattga cggcacaatc acggctcagg atacattcgt 2034121 cccttatttg aaccgttcgt ttaatctttc catttcatta aacgatatga cggattatga 2034181 tttaacaaag ctgttaaaca ttacccagga agaattttgg gattggatga atcaaaatga 2034241 agcgatcata tataaggaag cattgcttgc acagcatgcg aaacagtctc tcgatcttct 2034301 caaagaggag cacaagctta tttatattac agcgagacgg actcatttaa ctgatattac 2034361 ttatgaatgg tttgacagac aaaacattca ttatgaccac atcgaacttg ttgggggtca 2034421 tcacaaagtt gaagcggtca agaatcataa catcgacctg ttttttgagg atcatcacgg 2034481 gaacgccatg atgattgcga aagaagccgg gataccggtg attttgttca attcccctta 2034541 taatcagctt ccgattgatt caaacatcat cagagtaaac aactggctag aagccgttca 2034601 atggatgaac aacaacaagc atcacttaat acgcgtcaat aactgaaaaa ggagcccaaa 2034661 ccgggcccct ttttcatata tacgcatttt acgcagtagt gttttcttgg ttttccgctg 2034721 tacaatcagg gcatgtgcca taaatctcaa atttatgccc gctgacctga tagccatcca 2034781 aatcatcaca aagcttgtcc atcggacatg attcaatttc ctttgttttg ccgcaggcaa 2034841 gacaaataaa atgatggtgg tgatgggtga atgaacactt aaatcggaag agcttttcac 2034901 cggacagctc agttgtttcc aaaatcccaa gttcttcata taaagaaaga tttctgtaga 2034961 ttgtatcaaa gcttaagcct ggataatcat cattcagtgc agacagtacg tttttagcgg 2035021 taagatatct gtctgaatca gcaaaaagct gcagcatatc ctcccgtttg tttgtatatt 2035081 tatatccgtt ttcttttaat aggttcagcg cttcttggac gttcatgaag ggtccccctt 2035141 ttcgctttgc ttaagaacgt atcacatgta tgaaaaagaa aatggcagct gtctgtccag 2035201 caagccattt tctttactgc agataaaatt atacccataa aatgaataaa agtaaatgaa 2035261 agcctagtgg attgcgtttt tgaattttcc gcctctcgtt tcatgagtat tcataattgt 2035321 tatgaatgca ttttgatcaa cttcaaacac gatcgatttg agctttgtca cttccagcct 2035381 tgtgacaacc gcgtaaatta cgtctttttc ttcgtccgta tacccgcctt tccccttcag 2035441 cttcgttgtg ccccgaccga gacggtgcaa aatcgcgtcg gaaatctcat catactgctc 2035501 agacacaata atgacagctt ttgtttcatc aagcccttgg atcacggcat caatcgtttt 2035561 catcgcaata taataagtca tgaatgagta catcgcttgc tcaggaccga acacaaaaac 2035621 tgcccaaatg aaaatgaaca cattgatgaa cataacgaac tcacctacag aaaacgggag 2035681 ttttttggtc agcaaaatac cgagaatttc tgtaccatcc attgaacctc catttcgaat 2035741 aacaagcccg acgccaaagc cgagtaaaag acctccgaac acagtagcca aaataggctg 2035801 ggttgtaatg gcttctacat ggtgaagtga ggattcaata acggcaagcc cgacaatccc 2035861 tataaacgta gagactagaa aggtcttacc gatatattta tatccgaaga tcataaaagg 2035921 aatatttaat atgacaacga aaaaagcgaa attcagaaag gggtttgaca taaagaggtg 2035981 gtctaaaata agagatacac cgataatccc gccatcaata aaatcattgg ggattaaaaa 2036041 taattcaata cttacagccg cagatgcagc tcctaccaga atcataaaga ccctgaaaat 2036101 aaaatgggta aatgtttctt tcttatgttg ttttgttggg gtcataaaat ctcctttcct 2036161 gcaataacta ttttaaatac attataaatc tattttacca ttaaacactg acacatttta 2036221 ctgatttgcc catacattaa gtctggaggt ggaatgaccg atgattttat ttcaaagaat 2036281 tattttgcag cggcttaatc aggctactgc tgatgatttg ctgaagtact caaaacaata 2036341 cggaatcagc ttaacaagat cgcaggccgt tgaagtagcg aacctgttat acgggaaaaa 2036401 tgtaaacatc tttaatgaga gtgaacgaat gcggctgctg aaacaagtag agacgattac 2036461 atcgaaagaa acagctcaaa cagttaatga actattcaaa caatttacaa gctaaaaaat 2036521 gggggtgtta tcccccattt tttattgctg taaaatcttt tcaagcaatg tatcatcaaa 2036581 ttgtttttct ttcagcattt caatctcaaa acggtatggc ggttttttgt tctttttatc 2036641 ttcaccgacg tatggtgttt caagaatttt tggaatgtct tttaactgct catggtgaac 2036701 aacatattgc agtgcgtcaa aacctatttc accaaagcca atattttcat ggcggtcttt 2036761 tctcgcacct ttgacatttt tgctgtcatt gatatgaagc actttaatac ggtcaatgcc 2036821 aatgatttta tcgaactcat ttagcactcc gtcaaagtct tcgacaatgt tatacccggc 2036881 atcatgtgta tggcacgtgt caaagcacac tgacagctgc tcattgtgtg taacgccttc 2036941 gataatctgc gcaagctcct caaagcttct gccgcattct gatccttttc cagccattgt 2037001 ttctaatgca atctggacat tttgattcgg atcaatcact tcatttaagc cttcaataat 2037061 ttttttgatg ccggcttcag ctcctgcccc tacgtgagcg ccaggatgaa ggacaatttg 2037121 cttcgctccg atggccgctg tccgttcaat ttctgaacga agaaaatcaa cacccagctc 2037181 aaaagtggac ggatttgtcg tgttgccaat attaataata taaggcgcgt gtacgataat 2037241 ctcgtcaatg ccgttttctt gcatatgtgc ccggcctgct tctatattta agtcttcaat 2037301 tttctttcgg cgcgtatttt gcggtgcgcc tgtatagatc ataaacgtat tcgccccata 2037361 agagactgct tcctggcttg cagccagaag catatgtttt ccgctcatag agacgtgtga 2037421 gcctattctc agcaacaggt tcccctactt tcttttctta gattggtttc ttctctgttt 2037481 tttcttgatt ttctccatct catagctcat tttcttttta tacccaggct taaccttctt 2037541 cggctttttc acgagacgat gagcaatttc atccgcttca ttcggcgttt ttttacgttt 2037601 tttgcggcgc tgacggtcat cgcctttttt ccattcgccc ttttcaagct ctaagtactc 2037661 aaattcgatg cccatttttt caagtcttac taatgcatcc tcatcagtaa gctcataaat 2037721 ggtcatcgct tgtcctgatg agccggcacg agccgttctg cccacacggt gaacatagaa 2037781 atcgagatca tccggcagct catagttgat aacatggctg acacctttaa tatcaatacc 2037841 tcttgcggca aggtcagttg caatgatata tgtgaattcc aaatcattga tctgcttcat 2037901 gacttttttc cgctcacgtg gtgttaatcc gccgtgcagc aagccgattt tcatgccttt 2037961 gccagtcaga tactgggcaa tatggtcagc cgtatttttc gtgttggcaa acacaatccc 2038021 caggtatgga ttcagatgcg acatgatgtc aaaaaggagc ttgtccttgt cacgatgttt 2038081 cgaaggaatg aggatatgct cgattttcgc agcagtcacc tgttttggct ccacatgggc 2038141 gtatttcgga ttttccatgt atttcttcaa gaatggtttc agcttttccg gtatggtcgc 2038201 tgagaacaca agcatttgca gatcctcagg catgcgggaa ccgatgtaat ctacatctgc 2038261 aaggaatccc atgtccagca ttaaatccgc ttcatcaata acaagagatt ccgctttatg 2038321 aacacttaac gcctgttctt tgattaagtc agcaatccgt ccaggtgtac cgacaacaag 2038381 atgcggctgt attttcaatt tatcaattga tttttgttta tcagtgcctc cgataaaaca 2038441 tttcgagcga atctgacttc cttcttcacc ctgcgtgatt ttaagcgctt cctgataaat 2038501 ctggttggca agctctcttg tcggagccgt aatgactacc tgaacgacat ccttagcagg 2038561 atcgattttg tttaataaag gcagtaaata agcgtgagtc tttccagtac ccgtctgaga 2038621 ctggccgatg acgctttctt tttttaacac tgcaggaatc agccttttct ggatatcagt 2038681 cggttcgtaa aaaccaaggc gatgtactgc atctataata aatggtttca attcataaag 2038741 ttcaaatttc gtttctttca tttttcccag ctccttaaag cggcacatta tgtgtccatc 2038801 atcacattat acccgatttt gcttaaaaac accacgtttg caaggcgttt gttttattca 2038861 gttatgtaaa gcaaataccg cagcccatgc atattctaat agcagagaga gctgaaagga 2038921 ggtacaagta tgttttcacc gcagcagcca atgagaaatt acccacagcc cggaccgccc 2038981 cgccccatgc caaatcagcg aatgatgggc agaagaccgc ctaatatgcg aggaccttca 2039041 tttggagcac agcagcaagg ttttcagcaa gccggacaat ttcttcctca ggcaaatgcc 2039101 ggagcgagaa atggtgcagg tgcaggcgga ggcttaaaag gaatgctgtc aaggttcctc 2039161 cccggcggag gaggcgctgg cagcgccggg gttcccggaa ttccaggagc aggtgcagca 2039221 gcgagcggag gtgctggcct gcaaggcatt caaaatattg ccaatcctgc atcattatcc 2039281 agtatgcttg gaaatgtgca aaaagtactc ggcatggcgc agcaagtcac ccctatgatc 2039341 cagcagtacg gcccattagt ccgcaatctg ccagcaatga tgaagctgta cagccaatta 2039401 agtaaaagtg atgatactga gacagaggcc aatgaggaaa gtgaaaaaca atccgtttca 2039461 gaagaatcat cagaaaaaga aaaagagact gaaacaaaaa cctcagatgg gaacaaaaaa 2039521 tcaaaaccaa aaagttcttc tctcccaaag aaatctaaaa caactgacaa taaagaacaa 2039581 gaattaaaaa catctgcccc gaagaaaaag gaagctgcct ctcctgctcc gaaaagaaca 2039641 tcaggcagtt caaaaccgag attatatatt taacattctt tgatatctta agtgagattg 2039701 gctataatga gatcagaaga atgcaagaat agagccgttt gattacggct ttttatattg 2039761 cctttactca cttcagtatt ggaggacaac cgaaaatgga cgtaattaaa atttcaccgc 2039821 gcggctattg ctatggtgtt gttgatgcta tggtcattgc caaaaatgcg tcgctagata 2039881 aaagcttgcc aagacccatc tatatactcg ggatgattgt tcataataaa cacgtcactg 2039941 atgcgtttga agaggaaggg atttttacat tggacggctc taaccgtctg gacatcttaa 2040001 agcaggttga caaaggaact gtcattttca ctgcgcacgg tgtttctccc gaagtcagaa 2040061 gaatcgcaga agaaaaaggg ttagtcgcaa ttgatgctac atgtccggat gtgacaaaaa 2040121 ctcataatct aatcttagag atgaaagaaa aaggatatca cgtgatctat atcggcaaaa 2040181 aagggcatcc agagcctgag ggagccgttg gcgtagcgcc ggagatcgtt cacttagttg 2040241 aaacagaaga agatgtaaag aaccttgata tccaatctga gaagttaatc gtgacgaatc 2040301 aaacaacaat gtctcaatgg gatgttcacg acattatgga gcttgtcaaa gaaaaatatc 2040361 ctcatgtcga atatcaccaa gagatttgcc tcgctactca agtgcggcag gaagctgtat 2040421 cagagcaggc aaaaaaagcg gacttaacaa tcgttgtcgg agacccgaaa agcaacaatt 2040481 caaataggct tgctcaagtg tcagaggaaa tagccgggac aaaagcatac cggatcggcg 2040541 acttaagcga attgaagctc gaatggctga aaggcgttaa taccgttgca gttacagcgg 2040601 gagcttcaac accgacgccg atcacaaaag aagtcattcg ctttttagag cagtttgatc 2040661 acgaagatcc atcaacttgg acaactgaac ataatatacc gctcaaaaaa atacttccaa 2040721 aagtaaaagc aaaaaactga ggctgtaaaa gcctcagttt ttttatagaa atgtaaatgg 2040781 atttgtatct gtttcagaaa caaagatatt cacgccaaac tttttatcat tacacattga 2040841 tgtaagtttt ctcgtgacgc cttctttcat gattttttcc gcgtaatggc ccggatcaac 2040901 cacatttagg ccaagcatca tcgcatcatg ggccacatgg aagtataaat ctcctgtgac 2040961 gtaaacatcg gctccctttc gttttgcatg atgaatatac ttgtttccat ctccgccaag 2041021 aacagctact tttttcacca tgctgtcagc atccccaacc attctgacac cattgacgtc 2041081 aagcttgtct ttcacaaata aagcgaattc cttgagcgtc atctcatttt taagggttcc 2041141 gacacggccg agcccttttt cggcgggagt ctgttcgaca ggatagatat cgtaagcgac 2041201 ttcttcatat ggatggcttt ttatcattgc attgataaca gccttttcga cgcttttagg 2041261 aaatacagtc tcaagcctta cttcatgaac aagctcaagc tctcccactt caccgataaa 2041321 aggcttagct ccgtccaatg gcttaaagct gccgattcct tcagatgaaa acgcgcaatg 2041381 gctgtattca ccgatatggc cggcccccgc atttccgagc gcggctctga cctgctcttc 2041441 atattccttc ggcacgtaaa ctgccagctt tttcagagga tccgtataag taggtgccag 2041501 cacttccgtc tcactcagct ctaatgcttc agcaagcaaa tcattcacac cgccgtccgc 2041561 aacgtctaaa tttgtatgag ctgcataaac agcaatatca tgcttcaaac acttttcaat 2041621 taaccttccg gcaggctgat ctgttgaaat atgctttagc gaccggaaaa ttggtggatg 2041681 gtgtgcaata atcaagtcaa cctctttttc aatcgcttca tcgataacgc tctctaacac 2041741 atcaagtgta accatcacat ttttaattgg tttgtttaag gtgccgattt gcaggccgat 2041801 tttatctcct tcaaccgcat aggctttcgg ggaaaattgt tcaaacagct ggatgatctg 2041861 ctgcccattt acacttttag ccatgatcga ttacctcctt taacagctcc attcgatcgg 2041921 cgagctcctt taatttttgt ttgttttgct ctgtatccgc cgcttggctg atctgttcat 2041981 aaatgctttg agtgtgctga agctcttgtg tccacttttt caaaaagaca gcattttttt 2042041 cttttgccaa gaaagggcca acgagcatcc cggctgataa agaaataccg tcataagccg 2042101 catccctgtc tcccgcttct gccaccagca cctcatagca ctttccgtcc tcttcaagga 2042161 ttacctcatc tatcagcgca tatctttctt tataaagcca ctccctgata tgaacagcat 2042221 gaatattcgg ctgtaaaatg agccgttcct tccccgttaa tttgtctttg cccgcttcta 2042281 aaatgtgagc gatcaaagcc ccgcccattc cggcaatcgt aatggcatca gcttcacctt 2042341 ttttaatcac ttccagtccg tctccctgcc ttacagaaat gtgcgagttt aagcctgatt 2042401 tttcaacctg ccgctttgca gacaaaaatg ggccgtctgt tatttctccg gcaatcgccc 2042461 cgctggcttt atgattcagc accgcataac aaggaaggta ggcgtggtca gagccgatat 2042521 cggccatcac cgctccattc ggtatgtact ccgctactgt ttgcaatcgt ttagataatt 2042581 ttaattcgtt cacttgtcat cacaactttt ctcaatcatt ttttccttta ctatcatata 2042641 aaaaatcagc ccggaatcca agctgaagca aatgattttg aaattatttc ttttgatgcg 2042701 ggtctgcacg cagcagtcaa aaataaaagg ctgtcgagaa catctcggcg gcctgtgaat 2042761 gtataaagag aaaaatagtt cttttattta atttttgaca cccactctgc catatcatcc 2042821 agcttatcgg ccggaacaag accggaaggc attccattac cgcctttttc gatctttgtt 2042881 ttaatttcag cgacatcttt cttatcccct acacctttta agctaggacc cgaaacacct 2042941 tcataatttt caccgtggca tgcgatgcag tttgccttgt aaatttcttc tggtgaagcg 2043001 tttgcatctt tcttttcagc agatttgctt tctcctccgc tcgcaatctc ccgagagtca 2043061 tcaagtcctt ttactgataa aaagaaagtt agaccaattc ctaaaacagc gatcagcaaa 2043121 aatggaataa gcgggttcca tttcatttcc cttccccctt tttgatcctt ccccctatgt 2043181 aaacacttct aattctaact tatttttaca aaaagtaaat ggattgctat acaaaagttt 2043241 tttattcaca ctttatacaa aattgaatag aaacatgcct aaatctctaa tatccttttt 2043301 attctattgt ataatgtatt gtatacgctt acaatagaaa atatggaatt agattttgaa 2043361 atttttcacc acaatgttca tttgcaaatg acatcatttt tcagtaaaat aaaggcatat 2043421 tatccatata tctttttaaa aaaagaagaa cggatcttca agacccgttc catcttattc 2043481 aaggaaatct ttcaaacgtt tacttctgct aggatgtctt agtttccgca acgctttggc 2043541 ttcgatttgt cgaatacgct ctctcgttac tccaaatact ttgccgacct cttctaatgt 2043601 tcttgtacgg ccgtcatcaa gaccgaatcg aagacgcaat acattttctt cacgatcagt 2043661 taacgtatca agcacatctt ccagctgctc tttcaatagc tcgtatgcgg cgtggtcaga 2043721 aggtgaagtt gcttcttggt cttcaatgaa atcaccaagg tgcgagtcat cctcttcacc 2043781 gatcggtgtt tccagagata ccggctcttg agcaatcttt aagatttcgc gtactttttc 2043841 aggcgttaaa tccatatctt ccgcaatttc ttcaggtgtt ggttctctgc ctaagtcttg 2043901 cagtaattga cgctgcacac ggattaattt attaatggtt tcaaccatat gaacgggaat 2043961 ccggatcgtt ctcgcctgat cggcaatggc gcgtgtaatc gcctgtctga tccaccacgt 2044021 agcatacgta ctgaatttat aacctttgcg ataatcaaat ttttcaacgg ctttcatcag 2044081 gcccatgttt ccttcctgga tcagatcaag gaacagcata ccgcgtccga cataccgttt 2044141 tgcgatactg acaacaagcc gcaggttcgc ttcagccaat ctgcgtttag attcttcgtc 2044201 accttcttca atcttttgag cgtaggcgat ttcttctttt gcagaaagaa ggttaacccg 2044261 accgatttcc tttaaataca tacgaactgg gtcattgatt ttaacgccag gcggtacact 2044321 taggtcatta aggtcaaatt cttcttcggc tttggcaagc tgctgaatat taggatcttc 2044381 tgtttcttca ttctcactaa ttaattcaac accttgttca cctaaaaatt cataatactc 2044441 atccatttgg tctgattcaa tttcaaagct ggacatacgc tcagcaattt cttcatatgt 2044501 caaaacgcca cgttttttac cagactctgt taattgctct tttacttggt cgaatgttaa 2044561 ttctgtctcg tgggtttgtt tatcagccat tatggatccc tccttccaaa gcttgcaacg 2044621 aattctataa gcggtatgat tcttattcgg tccattcagg cgttttctat gtgaactgcc 2044681 tttaacaatg tgcgaataat gaaatgacaa ttcatgatga ggttaagcga tctatttgct 2044741 cctccgcaag gaatcattgc caataaatgc tcctcatcag ttctccagtt attttaaaga 2044801 tcggttcaat gtaacgattt cttgagccaa agaagcagct cttaaaaaat ctttttgcct 2044861 ttctgcttcg gctctttccg cctctttttc ttttatcatt gaccaatttc tttgattcaa 2044921 cacttttttt acataatctg ataactcggc ttcgctaagc tcttgattaa cctgaagcat 2044981 taatatatcg gacaagagct ggcttatatg atcatccgtc accctggcca tcagatgctg 2045041 aggcgtcagc tcggctccct cttcataaaa agcataaaga taagcggcta atgcccggtg 2045101 ctcatcaata ttaaattgaa accctacccg gtcaatcact tttttgatga cgctccgatc 2045161 tcgaagcatg tgagcgagta acagcctttc tgcattttca tacgccggac gcaaacgttt 2045221 ttgccttgct tttgtcgtca gatgcgctcg ccgcgtttta gtttcaccgc tattgtcagc 2045281 aggtttgttt tgcttgctga aaacagacag ctgctcagtt aaagactcct gtgaaagcga 2045341 aaactctgaa gcaagctgct ttacatagac ttcctgctct agagaccctg aaagcgtgct 2045401 gatttctttc agtacgtctt taatgtaagc taggcggtcg ccttcatcgg acaggttctt 2045461 tccttttcgg aaatattgca ttttgaacgc cattacggtg acacttgcgt caataatgtc 2045521 gtttttaaat ttttccccgc cgaatttttt gatgtaatca tcagggtcca atccgtcagg 2045581 aatcattgca actctgactt tgcagccttt tttttgcaga agctccgaag cttttaaggt 2045641 ggcttcataa ccggctttat cagagtcata gcaaagaatg atttcttcga cgtttcttct 2045701 caggatcttg acatgatcat ctgtaagaga cgttcccatc gtggctatgc tttcctttac 2045761 atccgagctt acggccgata tgacatcagc aaacccttca aataagactg ctctttcctg 2045821 ctttctgata tgaaggcggg ccttataaaa attgtaaagc agtttgcttt tatgaaagag 2045881 cggggtttca ggactgttca tatacttagg ctgctggctg ccaagagccc tgcctgagaa 2045941 agcaacaaca gccccgtgat gatcatggat cggaaacatg acacggtttc tgaagcggtc 2046001 gaaatatccg cttccgtctt cgcgtctgat caggagaccc gctttttcca tttgcgcctc 2046061 actaaatccc ctctttacaa ggaatttcgt gataaagtcc caagaatcaa gagcatagcc 2046121 aatctgaaat tcattaatca gctctttcgt aaagccccta gaaagcagat aatccagtgc 2046181 ctcttgacct tcttttgtat ttattaacaa atgatggtaa aatttcttca ggagctcatg 2046241 tgcctcagcc attttttgtt ctccagaaga ctctggccgg gctccggaat ggactgttat 2046301 atcatctgga aaatcaattt ggtatttgtc agcaaggtga gaaaccgact cggcaaaaga 2046361 atagccttcc atctgcctta aaaaagagaa aacattgccg cccgctccgc agccaaagca 2046421 atgaaaaatc tgtttgtcgg gcgatacgga aaacgaaggt gtgctttctc catgaaaagg 2046481 acagagtcca aagtagtttc ggccttgctt ctttaattga acataatcac ctatgacttc 2046541 aacgatatct gccgactttt gcacctgatc cacaatttca tctggtatcc gatttcccat 2046601 cttataacac tccgtcgtac attattcgat gctttagtgc aaaatccctt catcgttcga 2046661 caggattttt tgcagcagtg taataaatcg ttctcgatct tctttattca attttttagg 2046721 ccctttggca tatacgcctt ttcttctttg tttgccggaa aaatgacggc cctctagggc 2046781 aaaatcaatc gtgtcttcct tgtaaagacg acctctttcc gacataacag agacatttct 2046841 gttcaacagc agagatgcta atccgatgtc ctgcgtcaca acaatatctc ccggtttcac 2046901 gtgatttgcg atatataaat cagcagcttc tttatgagga tcaacatact tccatttttc 2046961 ttcattgctt ctggaaagct gataatgttc aaatgaagcg acaaaaagaa cttgaacttc 2047021 atactcggat gctgtttgta aaatttcatc ttttaccgga caagcatcag catcgacaaa 2047081 aatcgtcttt tcttgttcat taagaagagt aattctccat ccctccatta aactcctgca 2047141 taaaagcaag caaaatcgca catcctttat tattgtggat gtatatgaat ttgtcgaaaa 2047201 atttccggga gaaattcttg acatcttacc cataatagtt tattcgtatc acacgatcct 2047261 taaacctaaa attaatcatt ttatcacaat tttttattat aatacaaact tcacaaagat 2047321 gctattgttt ttcattattc ccttttggca cagccaaaaa cccaggatag agcgtcctga 2047381 gttatatgtt ttttgttttg agatgatgga taatatttgc tgtttcctca accgctttat 2047441 ttgaaacatc aacaacctgg cagccgatcc gatccacaat cttttcgaaa tactcgagtt 2047501 cctctttgat tctgttgata tttgcataaa tcgctttatc attaagcccg agtgatttta 2047561 aacgttcttt tctgatatga ttcagtttat cagggctaat ctttaaaccg atgcattttt 2047621 tcggatcaac gttaaagagt tcttccggcg gatcaacctc cggtacaatc ggaacattgg 2047681 caaccttcag gcgtttgtgt gcgagatatt gagacagcgg tgttttagac gttcttgaca 2047741 cgccgatcaa aacgatatca gcttttaaaa tccctcttgg atcacgtcca tcatcgtatt 2047801 taactgcaaa ctcgatggcc tccacttttt tgaaataatc ttcatcaagc tggcgcaccc 2047861 gccccggttc gtatttcgct gttaaaccgt aggctgtttc cattttatca atcaacgggc 2047921 cgataatatc ataatataaa acatttgctt tttccgcttc ggctatcaaa tattctctga 2047981 tttccggcac cacgagtgta aaacagataa tgccgccgtc tgcctttgca agtgaaatca 2048041 cttcattgat agtgcctata tcttcaacat aaggaattct tcttacatga gtatcatccg 2048101 ccgatccgtt aaattggctg agtgctgctt ttactaccaa ttcagccgtt tcaccgacgg 2048161 aatccgatac aacatagatg atgcggttat tcatattatc cccccgttag tttgcaatct 2048221 tataggattt cattttcaga taaactgaca agtattttgg tcatatttgt ttttgtcact 2048281 ctgccgatca cttcaaagcc tttatcggtg tctttgatga caggcagtgc atcaatttgt 2048341 ttttctatta agtgctttgc aatgtccatc acataatcct cgcgtctgca caccgtaatg 2048401 ttcggcatcc ttgtcatgat gatgtgaaca gggaccgatg taagctcctg ctggccaatg 2048461 ctcgctctga gcaagtcttt tcgtgaaagc accccgacta aaacagcatc gcggtccacc 2048521 acaaacagag tacctacatc ttctaaaaac atggtgcaaa tcgcatcgta cacagaaacg 2048581 ttttcgtgaa tcactacggg gatagattga aagtctttca cctgaagctt tttgagttta 2048641 tccgccaaaa gctgtgtgcc ggtttttccc gtatagaaat aaccgactct cgggcgcgcc 2048701 tcgaggaatc ctgacatggt gagtatggct aaatccgggc gcaatgtcgc cctggttagg 2048761 ttcagctttt ctgcaatatg ctcccctgta atcggcccgt tttcttttac aatctgcaaa 2048821 atatgttctt gccgtttatt tagttcgatc gtactcacca ccttttcact tcatagctat 2048881 gtaaagaaat aacaatccat attataacgt aaatatcttg taatcaaaca aaaaacttat 2048941 aaatggggaa aagacgatta ccgatcacac agcaaccgcc ttttctctct ttattttaca 2049001 ataagggcat tcatattcgc aaaggacttg atctcatccg ccaagcttac catttgcgct 2049061 aaacgatttg cctttaatga ctcattatcc gctataacca ttgtatgatc gaagtaagca 2049121 tcgatcggtt cttttaaggc tgcaagtgaa gcaagcgccg cctcataatc ttttttgctg 2049181 aagttttcct gcagattttg cttcgctgtt tggtaggcat caaacagttt tgcttcgtat 2049241 tcattttcaa acagatcagg ctgaatgtct ccgcggactc cttttttgct gatagagatc 2049301 actcggccta acgcttcggc tgtttcctta aagccaggtg caccaagctt ttgctccagt 2049361 acttgtgctt tatgcagcgc agagtacggc tcaagctcag agctttccag cacggcgtca 2049421 atgacatcat gtctgatttg ttcagcattc aagacatatt tcaagcgctg agtgaagaaa 2049481 tccagcagtt cattttcttt atcggtttga acgaaagtaa gcagctcttc aaatgaaatt 2049541 ccccagttgc ggtcaagaag aatcgcaaca ataccgcttg cttggcggcg cagtccgtaa 2049601 gggtcctggg aaccggtcgg aattacgccg atagagaaga atgaagcgat tgtgtcaagc 2049661 ttatccgcca ttgctacaac agctccggtg aaagtagaag gcgtttctcc gcccgctgat 2049721 ctaggcatat aatgttcatt aactgccgca gccacagctt catcttcgcc aagcattctc 2049781 gcatactttt cgcccataat tccttgaagt tcagggaatt catatatcat atgcgtcaca 2049841 aggtcgaatt tagaaatttc agcagcccgc ttcacatgtt ttaatgtatc ttcatcagcc 2049901 tgaagacgaa cggcaagttt ctctgcgatt gatgtgactc tcctaacctt atcagcaaga 2049961 gaaccaagct cttcatggaa aacgatattt tcaagcttct tcacatttgc atcaatgttt 2050021 agtttctgat cttctttgta gaagaatgaa gcatcagata aacgtgcgcg cagcactttt 2050081 tcattgcctc gggccacatt ttcaatcgcg tggctgttgc cgtttcggac tgtgataaag 2050141 tgaggcagca ggtcaccgtt tttgtctttg acagggaagt agcgctgatg ctctttcatt 2050201 gtcgtgacaa gcacttcttc aggaattgac agaaactcgg attcaaatga accgtaaaga 2050261 gctgtcgggt attctactaa atgattcact tcatcaagaa ggtcttcgtc aactggaatg 2050321 ctccaattgt tttcagcagc cattgtttcc agctgagatt gaatcatttg ctttcggacg 2050381 ctaggatcag caataacatg ctgtcctttg agctgctctt cataagctga aggtgattca 2050441 attgacactt catgtccgag gaaacggtgt ccctgtgttg tccgtccaga ctcaacgttt 2050501 gtgatcgaaa atggaatgac atcctgtcca aataatgcga caatccattt gatcggtcgg 2050561 atataacgca aatcttcatt tccccagcgc atgtttttcg ggaaatgcaa gcttgtaatt 2050621 aaaccgctca attctggcag aagcgacttc gtttcttggc cggcttggaa tttttgcacg 2050681 aatacatact ctatgccttt tacttctttg atgtacaggt cttccacatt tgcgccttgg 2050741 ccttttgaaa agccgattgc cgcttttgtc cagttcccgt ccgcatcaag ggcaattttt 2050801 ttcgcaggcc cttttgcttc ttcttttata tcatcctgct tttctgcgac atccttaacg 2050861 aacacagcaa gacgtctcgg tgtattgaag agtttcactt caccgtgagt aatatttttt 2050921 tctttaagcc agcctgtcag cttgtcgcca agctgaacca tgctttcatt caaaaagcgc 2050981 gccggcattt cctctaatcc gatctctaaa agtaaatcct gtttactcat gagaagaacc 2051041 ctccccttta agcattggga accctagttt ttctcgttcc tcatagtagg tttttgctac 2051101 ttttctagct aaattccgca ctcttgcgat atagcccgtc cgctcggtaa cagagatcgc 2051161 acctttggca tcaagcaggt tgaaagtgtg cgagcatttc agcacatagt catatgctgg 2051221 atgaacaagt ccgttgtcca tttgcttgat cgcttctttt tcatatgtgc tgaacaattg 2051281 gaacagcata tcgacgtctg atgtttcaaa cgtataaaca gaatgctcat attcagccat 2051341 catgaataaa tcttttactg taaaccctga cgtccattcc aagtcaaaca cgttttcttt 2051401 atcctggata taagacgcga gacgctcaat tccatacgta atctctacag aaacgggttt 2051461 acactctaat cccccgacct gctggaaata cgtaaattgt gttatttcca ttccgtcaag 2051521 ccaaacttcc cagcctagac ccgcgcagcc taaagacgga ttctcccagt tgtcttcaac 2051581 aaagcgaata tcgtgctcaa gcggatcaat tccaagagca cgcaaggaat ccaaatacag 2051641 ctcttgaatg ttatcaggtg acggtttaat aatgacctgg aactgatgat gctgatacag 2051701 tctgttcggg ttctccccgt agcggccgtc tgccggacgt ctggaaggct ctacataagc 2051761 cactttccac ggctcaggac cgatactgcg caaaaatgta tacgggctca tcgtgccggc 2051821 tcctttttct acatcgtaag cctgcataag cacacagccc tgactggacc aatgcttttg 2051881 caaggttaga atcatgtctt gaatattcat ttcaagcacc tccacttttc tttcataagt 2051941 tgactgcggc agcaaccaaa aaactcccgt ctctatgctt gccagccgca aacataggga 2052001 cgagagttct cccgcggttc caccctagtt gctgagaaca aaatcccagc ctctttttta 2052061 aaattgctca agaatgcctt tcgttgcgtg ctcatcctta gcttacaccg ccctaaggtc 2052121 gctttcatga ggtaaacgca agtacttctt tctctcactg caacatattt tataataaat 2052181 gatcatataa aaagatggac caaatgtcaa cttttgtttt cacccataag atgtttcatg 2052241 ctttccattt gatctaaaaa gcgctttgat tttaaataca atcccgaata ttcttcgtaa 2052301 tataaatcaa tcacttgctt taattcagct tttgtttcct cttttaagga cacattgccg 2052361 agtctcgaca gatcaaaata gtaaaagagc cttaacagcc ttgccgtttg cggtttaatc 2052421 ggtatcctgt aaggatcttt ttcaaaacag cggtggcata taaaaccatt atcacgaaca 2052481 gagaaatgaa aggttccgtc ttggctttta caatgtacac aatgattcag ctcaggatac 2052541 aggcccatga caccgagcat cttcatttga acaatgaagg tgataacatc cggatctgtt 2052601 ccttcattca actgttttaa tgattctaat atgaattcaa ataaataagg atttggcttt 2052661 ttttcttctg tgcctctgtc gactaactca gcaacatagg cagcatatgc tgttaaaaac 2052721 aagtcttccc tgatgcctct catgctgagg atcatttccc cctgctgaag cgttccgagg 2052781 cccgatgttt tttgcattaa gaaagaacca tacaaaaagg gctggctgac tgctgataaa 2052841 cggctgttcg gttttttggc gcctcgtgcc ataacaccta tttttccgtg ttctcttgtc 2052901 agtaatgtta cgattttatt cgtctctccg taatcatttg tgcgaagaac gatcccttca 2052961 cattttgtca gcatttccgc accttcctca agcaggagcg gccaagaggt ttataaaatt 2053021 ggataatcaa atcgggctag ctcatcttct agttcttcgg gtctttccat gttctctttt 2053081 tccagttctt taaaaagaag atacgtatca acatttcctg tttgagaaaa tacgttccag 2053141 gtaaaattca acacaagaaa cccacctttc tgtagttaaa ctagcttacc taaactccaa 2053201 attcttacct ttatcttgac cagatgtcct ccatttcatg ttaaacaaaa tttgctaatg 2053261 tatccctgtt cctgtgagat aatgacacac acgggaagag attaatattc gtcctcttta 2053321 aagccaaaat cgcgaagctg ggacatttta ttacgccagt ctttctgcac tttcacccac 2053381 aattcaaggt agacacggga gcccaacagt gcttcaatat ccgctctcgc tctttttcca 2053441 acctctttta gaaggcttcc ttttttaccg atcacgatgc ctttctggga atcccgctcg 2053501 accacaatcg ttgccgctac gtgcacagaa ccgttgtcct gccctttgat ggattcgatg 2053561 gccaccgcaa tgctgtgcgg gatttcttct ctcgtcaaat gcagcacctt ttccctgatt 2053621 aattcagaaa tgataaatcg ttcagggtgg tcagttacct ggtcactcgg atagaattgc 2053681 ggcccttccg gcaaatacgc ttcgatctgc gcgagcaagg tttcgatgtt atttccttct 2053741 aaagcagaaa tcggaacaat ttccttaaaa ggataacgtt tgcggtattc gtcaattagc 2053801 agaagcaatt ggtcgggatg aattttatca attttgttta cgattaagaa tacaggcgta 2053861 gacatcgtct gcaatttctc aatgatgaat tcgtcgccct tcccgtagcc ttcctcagca 2053921 ttgatcataa acaagatcaa atcgacttct tttaatgtat tttgcgccac tttcatcata 2053981 aagtccccaa gtttatgctt aggtttatga atccctggtg tgtcaataaa aatggtttgt 2054041 gatgtgcctg tcgtcagtac tccttgcacc ttgtttctcg tcgtttgggg cttatcgctc 2054101 atgatcgcga ttttttgtcc aatgactctg ttcaaaaatg tagattttcc tacgtttggt 2054161 cttccaataa tggatacaaa tcctgattta aagctttcgt tcgtcatgta aatcctccga 2054221 tgaaaatgcg cctggcaata attcttccac agtcatttct tttatttgtc cttgtaaatt 2054281 agtcagtacg acaataacgt cttttgtgca aagctcagaa atcacctgtc ggcaggctcc 2054341 gcacggagat actggtccag gggtgtcagc cgcaacggcc agcatctgaa actctgtatc 2054401 cccttcagaa acagctttaa ataaagcggt acgctcggcg caattgcaca tgctgtatgc 2054461 cgcgttctca atattgcagc ctctgtacac ttttccatcc ttggtaagaa gagcggctcc 2054521 tacttggaat ttggaatacg gcgcatatgc catatcacgc gcttttaaag cttctgttat 2054581 taattcttgt ctgttcatgt gtacattcct ctcttaccta taatggtacc gctatcactt 2054641 tatattttac ataatcgcgc gctttttttc acgcccattt ctaaaaatgt aaaataaatg 2054701 taagaatttt cagccattac agctttggca aaaaaataag taaaccaatg atacacgaaa 2054761 tcacggcaaa aacgcaaaca gccccggcgg cagcgtcctt ggccgcttta gcaagagggt 2054821 gatgtttgtc agttattaaa tcaaccgtat gttcaatggc tgtatttaaa agttcaagcg 2054881 aaaacatacc acctatcaaa aggaatataa tcatccactc aataatgctg agctctacaa 2054941 ggaagccgca aatgagaaca gcgcaggcgg ctgcggcatg aaattggaaa ttccgctccg 2055001 tccgcgctgt ttcccatatg ccccggcctg catgcacgaa gcttttgaag aatcgattca 2055061 gctcatttct atgatctttt gagtccataa gcgtccagca attccttttg cttagtaaac 2055121 atctcctctt cttcctcttt cgtcatatgg tcatatccta aaaggtgcag aaatccgtgt 2055181 acagctagaa atccgagctc tcttttaaaa gaatgattat actcctctgc ctgctctctt 2055241 gtgcgatcgg cactgatgat aatatcacct aaaaccggag gcatttcggc gcccacgatt 2055301 tcgatctcgc cttctccctc ttcttcaaga gcaaatgaga tgacatctgt cggagcatcc 2055361 tttccccggt attctttgtt aatctgatgt atgtcatcat tggaaacaat cgtgacagaa 2055421 acttcagcct gatcctgaac gccttcacgc tcagcggcaa attgaagcag attttctact 2055481 tctttgagca tctcttctga gacgcttccc gtttcatcaa cgatatcaat cagtaaactc 2055541 atctatttca ccttcttagt agcctccgga tattcaatcc gggagtggaa aattcctttt 2055601 aatgttgcac agagcgtttt tgcgattgta tccagctctt taaatgtcaa atcgcattca 2055661 ctgaactgtc cgtcctgaag cttatcggat ataatacccc ggacaagctt ttcaattcgt 2055721 tcaggatttg gattgtgcat ggatctgacg gccgcttcaa cactgtcggc cactgatata 2055781 attgcggctt cctttgactg cggcttcggt cccggataac ggaactcttc ctctgtaatc 2055841 tggtcgcctt tttccttcgc tttatagtaa aaaaacttta aaagcgaggt tccatgatgc 2055901 tgctcagcaa tatcgacaag ctctttcgga aatttatagc ttctcagcat attcgcaccg 2055961 tctgtcgtat gcgagataat aatatttttg ctcaactgag gtgacagctt gtcatgcgga 2056021 ttgtcaatat tcatttggtt ttcaataaaa tattgcgggc gctttgtttt tccgagatcg 2056081 tgataatatg cgccgactct tgcaagcaaa ccattagccc caaccgcttc acaggctgcc 2056141 tctgataaat tggcaaccat tacactgtga tgatatgtac ctggtgtttc cgtcagtatt 2056201 ttgcgcaata gcggatggtt aggattagac agctcgagca gcctcatggt ggataaaatg 2056261 ccaaagcccg tctcaaaaaa cggcatcaga ccgatgatca atacagatga agcaaacccc 2056321 gacacaaccc ccatgagcat taacgtgccg atttcaagac ccgacagcgc agtgttctgg 2056381 atcaataata aggatagaac gacaaccata ttaataaacg ccacgaaaag tccggtctgc 2056441 aaaatctttg atcttgcatt gtgttttcct aaaaataata cacctgaaat gccgctgatc 2056501 aaataataaa tccctatgac ataattgaat gttcctgtca caccctgatt aaacatcata 2056561 cttccgcaaa tcgcaagaat gatacttccc aaaatggcaa tgcgttcatt catcagcagt 2056621 ttgattaaga tggcgccggc cgcaatgggg accagatagc cgatattatt atactccatc 2056681 ttctgaaaca aactgacaac ctccatgatc acaagcaaaa gtgttgtgat tatggagaat 2056741 aacagaatgg attggttttt aaacttcaga ttttgtttct gtttttcaaa ataatataca 2056801 agtgttgcaa tgaaaagtcc gatcataatc aatagcccgc tgatcggttt aaagagattt 2056861 gagttattta ataacccggt cagctcaagt ttcctgtaca cttcccgatc aatgaggtca 2056921 ttttcttcca cgagcacttg cccctgtttg atttgaacct gctggacatt atctgaggct 2056981 tcctgccgtt ttgcctctgt tgctttcgga tcgaagacgt aattcggaat aatagcaaaa 2057041 cgcccgattt ctgtcgcggc tcccaagtat ttagacggaa tagaattgct ctttagctct 2057101 ttttctacct tatcctttgc atcagatagt ttatccgaag ggatttcact gctcatgacc 2057161 gtatttaccg cggtaatgac cgtatctctg acaaaagaaa agtcttcact gtctgctttc 2057221 agcaatgtct tgatggaatc ctccgatata gaatcattca catctgatgt caatttgtcc 2057281 tttacagatt tgaccattga tttttccgat ggtgatttac tgccttcttc cgatgatttt 2057341 ttcacttcac taatactgtc gaatattgat gacacaaggt caatccgatt gtctgtatat 2057401 tcttttttta atgtatattg atcttcaacc gcgtcctcag cggcttgctt tttttcctct 2057461 gtggcttttt gatcttctac ggttgccgga gcgtaaatgg tcttgtcgct gactgaaaac 2057521 aggtctaaat caagtgtttc cggcttaaca tgtacaaaga gcaaagcaaa cataatggca 2057581 gccagcagaa gatacagcag tacatgcatg gagcgggcat ttttaaaact gctccatttt 2057641 tttgagctgc ttttggtctt agccttcttt ttcaacacaa gaacctcctc ttgaaacatc 2057701 aagcccataa gcaatcataa aaatgacccg ataacgcgcg atcgggtcat tcagcattaa 2057761 ttttgcttat cgtatgcttc aataattttc gcaacaagcg gatgtctgac cacgtctgtc 2057821 tggtctagct caatcataga aatgccgtct attcctttca gcatctcctt cgctactgca 2057881 agtcccgatt tgacgccttt cggcagatca atttggctaa cgtcacctgt aatgatcatt 2057941 ttagagccaa aacccagtct cgtcaaaaac attttcattt gagcaggcgt ggtattctgt 2058001 gcttcatcaa gtataacata agcatcatcg agcgtccgtc ccctcatata tgcgagcgga 2058061 gcaatttcaa tgatgcctct ttccatcaga cgttctgtat gatctgcccc aagcacatca 2058121 tggagagcgt catacagcgg gcgcaaataa ggatctactt tttcttttag gtcacctggg 2058181 agaaaaccaa ggctttcacc ggcttccacg gcaggtcttg ttaaaatgat ttttttgata 2058241 tgtccgtttt ttaaagcatg gactgctttt acgacagcca ggtacgtttt cccggttccc 2058301 gccggaccaa tgccgaatac aaggtcattc cgcttcatag cggccacgta ttcccgctgt 2058361 cccattgttt ttacacggat tgatttgcct tttgcgtttt ttgtaatttc ttcttcatac 2058421 atgctttcaa agtattcaag ttcattcttc tttgccattt tgatggcgta aatcacatca 2058481 cgttcagaga tctctatccc cttgcgaatt aaagcgagga gcgatcccag cagcctgtct 2058541 gcaatctgaa acgattcatc atcgcctgaa acataaatcg tctcgccgcg cgtaatgata 2058601 tttaaattca gatctttctc catcaatttc aaaaaagaat cttggttccc gaagagtgaa 2058661 agcgcctcgt ccgggttttt cagtttttga ttcatcgcaa gtaaatgttc tgtcattctt 2058721 cagtctccct gacaataggt gtggtttgaa cgatatcttc tataacttgg tagagaataa 2058781 tcaactttac tttaccattc tcaacagtct ggtgcaaaac tttttcactt ttcacctcgc 2058841 cgttttcgcc tattttatcc tctacatcct gtttacccaa tttaatgcct tcttgaactg 2058901 cttcttcttt tgtatatttt cgcaaagcct cttcactttc tctcgtttgc tctttgacat 2058961 aggatacagg gagcttaaat ccgagaaaat gaagcgaatg cttttcttgt tctgtttttg 2059021 gatgcttcaa ttcctctttt ttaaacgtca tcccccagat cgggattgcc aaagaaccaa 2059081 aagaaagctt gtgctttgtc cttactttgc ccgtatagac gttaaataat gtttcaagcg 2059141 ggactgtcac ttctgatcta taccaggttt ctccataaat ttctgctttt gaggcgactt 2059201 cctgctgatg gtcttcgctg ccgatcagtc ccgaaacaag cagctgtccc ttttcaacat 2059261 gatcgtgtat ggcggccatg ggctgtcctt tttgcacaaa cattctcgta atggttgctt 2059321 tctttttggc gacaatattg cgcgggctaa catatttttc tttttcgggc tcatttttct 2059381 ccacaacttt catatgaatg gtcgtcccct tcagatcaac tccgacccaa gtgatattgt 2059441 ctattccatt ggttaatgat ttctgtattt tttcgggcga catcattaaa aactgcagac 2059501 ggcccttttt gacgccgatt tcattaagat gctgcctcat ttgatgttct gtttcaggct 2059561 tagcgcctgt cacatcaatt ttccacacca tattggacag caaaaacaaa agaatgaaaa 2059621 aaatcgcaaa accgatcgta aaccctatat tcagctttga tttcagcaac aggaagggaa 2059681 atcccttccg attgataaat cgggctttac atttaaattt acttcttacc cgccgaaagg 2059741 catgtacatc ctgaagctgt atatataacg atacggcttc tttctttttt ttgacatgaa 2059801 agaccggaat cccctgtctt gtgcattcat taaggagccg ctcaatccct cttcccgtca 2059861 attcaagctg gaccttaccc gaaaaaaaag acagccattt atttttcaca acatttcccc 2059921 ctcggcttta tgactcaaca tatcgaacga catcaatcgt accctccaaa agtatctctt 2059981 ccggaagaat cgccttgatg acaaaatttt taccagatat gatgcactgg ccctgcttca 2060041 gcatcagccg cacttcattc tcactgaaaa gcaaaaggcc tctgtggttt tctatgtaga 2060101 tatgaagtct gccaaccatt gtaatcctcg gcagatccat cataacgtcc gggggaattt 2060161 ccaatgctct tgtcagccaa gctttcatac gattctttct ttgccccata caaaaagaac 2060221 cccctttcat ctcatatgta tgatttgaaa ggaggttcta acactttaat ttttacgggc 2060281 cgggcgcatc gtacggtgag gttttttcgc ccgtggaggt ccgaacacct ctcctagaac 2060341 gatcccctgt acgacggtgt ctttattcac ctgaagcatt ttttgttttg tgtatactgt 2060401 tttttgtttg gcagcagcaa gatctcgttc cagccctttc aggtttcttg ctgtttccct 2060461 gcgtctttct tccgcttccc gtcttgcctg ttccatacgg ttagggatag gtgcaggggc 2060521 atcttctttt gactgcttct tttgaggaga agcagattgc acgtgttgag gtttttttct 2060581 tttttggctg ttttgctttt cttctttgct ctttttgccg aaaatcgcag aaatgattcc 2060641 gatgatcgct gcaataataa gcggattggt cagtaaatct tccatcagcg ttctcccttc 2060701 ttagagagat tatgatttgc ggtcttcatc cgaagggtct ttcgtcagct tgccgaatga 2060761 atcacgcatt tctgtgtcag catcgatgtt cttgatattc atgtaatcca tgacgccaat 2060821 attcccttca cgcaaagctt ctgccatcgc aagcggcact tccgcctcgg cttctactac 2060881 tttcgcgcgc atttcttcta cgcgggcacg catttcctgt tcttgagcga cagccatcgc 2060941 acgtcgttct tccgcttttg cctgcgcgat gtttttatca gcctcggcct gatcggtttg 2061001 taaaattgcc ccgatgtttt tgccgatatc tacatctgca atatcaattg agagaatttc 2061061 aaacgcagtt cctgagtcca atccttttcc aaggactgtc tgagaaatca tgtcagggtt 2061121 ttcaagcact tttttatgat tatcagatga accgattgta gaaacgattc cctcacctac 2061181 acgagctaca atggtttctt cccctgctcc cccgacgagg cgctcgatat tcgctcttac 2061241 tgtgattctc gctttcgctt tcacttcaat cccgtccatt gcgacgccgg caatgaacgg 2061301 tgtttcaatc accttaggat taacgctcat ttgaacagct tccaacacgt cccggcctgc 2061361 aagatcaatg gcagcacagc gctcgaatgt gagttcaatg ttagctcgct gagcggcgat 2061421 aagcgcgttg acgactctgt caacattacc tccagccaga tagtggcttt caagctggtt 2061481 tgttccaaca ttaagtcccg ctttatgcgc tttaatcagc gggttaacaa cccgattcgg 2061541 aatgacgcgg cgaagcctca tcccaactag agtgaaaatg ctgattttca ctccggctgc 2061601 caaagctgaa atccaaagca ttacaggcac aaatgtaaaa aatactgcca aaacaatgat 2061661 cgctactgcg acaattgcca gaatcataag tgttgacgga tccatataac ttctcctcgt 2061721 ttctatttaa atttctctca cgacaatgcg tgagccttct acttttatca cttttacttt 2061781 tttatctttt tctgtaaacg atccctccga tacaacgtca aggcgttcat catcaataat 2061841 cacggtaccg gaaggacgca gcggtgtaaa ggttataccc acttttccca ttaagtccgt 2061901 gcgcgtttga tttgaaacgt agccgctctc cgtgtttgta gaatcattta atatcaattt 2061961 cttaaagaat ttcatacgct ttcccaacac ccttgtcagt aaaataaaag ctgtaatcga 2062021 aacagctgag gcgatcaaga gagaaaccgc catgacagtg aagctccccg cggctaaaaa 2062081 caggctcgca ataatcgctc ccaagcccag taatccaatg attcctccgg gaagaaaaat 2062141 ctcaagcaga atgagaatca cccctgctat aaagaggaga accgtctcat acccggcaag 2062201 gccggctgca agatgcccgt aaaagaacag caataacgca atgagtccag ccgttccagg 2062261 gaggccgaca cccggggaaa aaagctctac cgtcagacct aaaaaagcga ttgtcagcag 2062321 aatagggaca atgaccggat tcgtcagcca tcttgccgtc ttttccgcaa agctctcctt 2062381 tgcatagctg atctgcgcct tttcgaaccc aagcttcttt acgagcgtgg acaaattgtc 2062441 agcagtgcct tctgaatagc ctacctcaat cgccttgtct gcgttaagtg tcagcagatc 2062501 tcccttaggc gcgccaactt ccttggcatc tatatctggg tcagccattg cgagcgcata 2062561 ttttggatcg cggttatttt tcactgcggc atcttccatc tctgccagcc aaagtgattg 2062621 agctttttgg tcagcggcat tgccttggcc atcaacaatc gcggcggctc ccatttttcc 2062681 gccaggcgcc atataaatgt gatctgcttg aagtgcaata tatgcaccag cagacaacgc 2062741 gcgtttgttg acatatgcag ttacggggat ctcgctttcg gttatcaaat cggccatatc 2062801 aatagcagat ttgaccaatc cccccggggt attgatatca agaataatat ggtctgcatg 2062861 tgcatccttt gcgtcttgta acgaacggga caaaaacgag gcgagaccct gttcgacatt 2062921 tttttcaacc gggatcacat aaacagtttg tttttctgct tttgcgttca gctgtacgcc 2062981 taataaagaa agtaaaaata tacccaaaag agcagcacgg aatcctttga tttgaagcaa 2063041 gggcggtgta tccctccttc cttttataat aagtgccttc tcttcatacg taacaaatgt 2063101 atcaaaggtt tcattttttt atgtataaaa aaagacatct ctcttagaaa gatgtccttt 2063161 tctttgccat ttaagacagt tgactgctca caagcttatt aattaaactt ccgtcagctt 2063221 taccttttac tttaggcata attgccccca tcactttgcc catgtccgct tttgagctcg 2063281 caccgacctc cgcgatggtt tcatttacga ttgtacgcag ctcttcttct gacagctgct 2063341 caggtaaata aacttctaaa atgtccagct ctttttgaac tttatctact aaatctaaac 2063401 gattagcgtt tgaaaattcc tggagggagt ctttacgttg cttaagttca cgagaaagga 2063461 cagtgagttc ctcatcctcg gtcaaactgt ctttcttaag cttaattgct tcattttgaa 2063521 gtgaagcctt aaccattcga acgacagtca gtttgtcttt ctcacggttt ttcatataca 2063581 gcttcatatc ctggttgaga cgctcaagaa gactcataaa tccaccctct tttagaattt 2063641 gcgttttcta gcagcttcag actttttctt gcgctttacg ctaggttttt cataaaattc 2063701 acgctttctt gcttcttgca aagtacctgt ctttgataca ctgcgtttga agcgacgaag 2063761 agcatcttca agcgattcgt tttttctaac gaccgttttt gacattctct ttccctccct 2063821 ccgaatacac caatcgacta cctttaagtt acacatataa acatgtactt tgacattata 2063881 atataagcca tcagtcaggt caactaagtg agttcacttt tccgtcatga gtgcgactgc 2063941 ctgtctatat aatgaaagaa aggggttggt gaataggatg ttaattctga ttagctttac 2064001 tgctcttata ttattctttc tcgcaggcat gaacatgctt cgaaagggct taatttcaat 2064061 ggcgtactca aaaattgaag aacgtttgct tttatttaca gaccatccgt taaaagcgtt 2064121 tcttatcagt attgtattta cggggatact tcagagcagc tcagccttta tggtcattgt 2064181 catcggcttt gtaagtgcgg gcgttctttc ttttaagcgg acgatcccga tgattctggg 2064241 gacaaatgtt ggctctactt ttacaactga atttattgct atcaaaatgg atattgtgat 2064301 ttgggttctt ttaataggag gtttattgtt ttttctgact ggcaggtatc ctttgaaaca 2064361 gctgggaaca agcttccttg gactgggcat catcttcttt tgcatcagcg gattcagcca 2064421 tcttgccggg ccgctgacaa agctgaaaac gggcgccgac gttctatacc atgttaacga 2064481 ttcaaactgg tccgctttgc tcatcggcat ggtgttaact gccatcattc actccagttc 2064541 tgtctgtatc ggcattttga tgagttttat gaatgaaggg attatcggac tgacacaggc 2064601 gatgagcgtc gtactcggat caaatatcgg gacatgcatt acagctgtca tggctgctgt 2064661 atccggcgga tatgcggcga aacagacagc atatgcccat gtggtattta acgtgctagg 2064721 ggtggctcta gtattgcctt ttctgaccgc agcgaccggc tttgtagagc agttatcacc 2064781 tgatcccgca caaaagatcg cgcatttcag ccttttattt aatgtggtga cagctctttt 2064841 atttcttccg cttacaaact tgttttaccg attgattcac cttcttatcc cggctaaata 2064901 aaaaaatcgg tacattttaa tgcaccgatt ttttaggtta agaagacaaa cgcatgtgtt 2064961 cagttatttc atcctcaacc acacggacaa actgtccttc gttgtaagga taacctgctt 2065021 ttaggatttt gacttttacg attttgccga tcatatcttc cgtacctttg aaaacaacct 2065081 tcatataatt gtctgtgtaa ccgacaaaca tattttcttc ttctgtttcc ttaaacgctt 2065141 cctcagggat aatctcaagc acttcatttt catactgaga agcgtattct tttgcaagct 2065201 ggtcagaaag agcaatcagg cggtgcacac gttcgttttt cacgttttca tccacttggt 2065261 cttccattcg tgcagctggt gttcctgtac gcttactgta agggaaaaca tgcagctcag 2065321 agaatttatg ttctttaata aagttatagg tttccataaa ttcttcttct gtttctccag 2065381 ggaacccgac gatgacatca gaagtaacag ctaagcctgg cagtgctttt ttcaatttat 2065441 ttaaacggtc tgcaaagaat tccattgtat atttgcgtct catccgttta agcactgtgt 2065501 ttgatccgga ttggatagga atatgcaaat gattcactat cttatctgag cggtctaaga 2065561 cctcgatcac ttcgtcagtg atttggctgg cttcgattga agaaattctg atccgtttca 2065621 cgccttccac acgggtgtct aattcgctca aaagcttcgc gaagttgtaa tctttcatat 2065681 cttcgccgta gccgcctgta tgaatacccg taagaacaat ttccttatat ccggcatcga 2065741 caagctgctg cgcttgttta atgacttctt cagggtcgcg ggagcggagc aggcctctcg 2065801 cccacggaat gatacagaat gtgcagaaat tattgcagcc ctcctgtatt ttcaatgacg 2065861 ctcttgtgcg gtccgtgaaa gcaggcacat caagctcttc atatactctt gctttcatga 2065921 tgttgctgac gccattaatc ggctggcgtt cttctcggta ttggtcaatg tagccaagca 2065981 ttttttcacg gtcctgtgtt ccgactacaa tgtcgacacc ggggatcgcc ataatctcag 2066041 caggtgaggt ttgcgcgtag cagcctgtga cacagatgac accgtcagga ttttgacgaa 2066101 tggcgcgtct gatcacttgg cggctttttt tatctcccgt atttgtaacc gtacatgtat 2066161 taatgacata tacatcagct gtttgttcaa agtctcttct ttcatagccc gcttctttga 2066221 aaagctgcca gattgcttct gtttcataat ggttgacttt acagccaagc gtatggaaag 2066281 caacagttgc cattactgat cacctcttaa taactctgtt tgataagaaa tcgcactcaa 2066341 cgcgtatagc ggagcggttt ctgtccttaa aattctcggt ccaaggccgc acgtcacacc 2066401 gtcttgctct gtgagccgtt caacctccgc ttctgttaaa ccgccttcgg gaccaaatac 2066461 gatcaataga gatgatcctt tcggaaggct gcttacaatc gcgctgaatg cgcttatttc 2066521 cccttgcttc gatgactcct cgtatgcaac gacacattta tcgaaatcct gcatcctttg 2066581 aagaagctgc tgaaaagaat ggacatccat cactcgcggc acttcgttac ggtacgattg 2066641 ctcagccgct tccttcgcaa ttttcgtcca tctttcccgc tttttctttg cctttttgtc 2066701 atccagcttg acaacagaac gcgcggcttg gaaaggaata aaggcatgag ctccgagctc 2066761 agtccccttt tggataatcc attcaagctt atctcctttc ggaaggccgc tcgcaatata 2066821 gacctttatc ggaagctctc tgttttcatt cgtccattct atcacaaggc aggacacttt 2066881 atctttggaa acagattgaa gttcacattt tgcctcgaag ccgtcttgag agcagcagat 2066941 aatctgatct ccctcattca ttctcatcac gttcacaata tgatgaactt cttcgccggt 2067001 aatcgaaaaa gtcggcgctt cctctatttg ctgcttcgtg agctcgataa aatatcgttg 2067061 catacgctgt gacacctact aactgttatt ttttcgcaat aatgctgacc caatcttcca 2067121 ttgaaaggat ttctacaatg gtaaagccag cttgttccag tgcttctttt acttcttgtt 2067181 ttttatgacc gatgattcct gacgtaataa agtgaccgcc ttcttttaac aggctgtacg 2067241 cttgtgaagt aaagcgaaga atgacttcag ccaaaatgtt ggccacaatc acatcatgtt 2067301 ccccttcaat cccgtctaac aaattgtttt gcttcacttg agcaatatcg ctgactttgt 2067361 tcagcttgag attgaggcgt gcactttcta cagccacggg atcaagatcg taggcatgaa 2067421 ccgattcagc ctcaagcatt gcagccgcaa tacttaaaat tcccgaacca gtgccgacat 2067481 caatcacctt atcacccttt tgcacaaagc gttcaagcgc ctgaatgcag agtacggttg 2067541 tcggatgtgt ccctgtgccg aaagccattc ccgggtccat ttcaataatc agttcatcag 2067601 tatggaccgg cgtatattcc tcccacgtcg gcacaattgt aaacttttca gaaattttca 2067661 caggatgata atactttttc caggcagtcg cccactcttc ttcatttact tcagaaatag 2067721 tgatgtggtt tctgcccaaa tcaatattgt aaagaaggag attattaatc gtttctttga 2067781 tgccgtctac agtttcgccc agaaaactgt taaccggcag atatgctttg acaatgacac 2067841 cctcatctgg gtaatcattg gggtcgagct ggtagatttc cccgtacaca ttctcacgtt 2067901 ctttaattaa atcaagcggg tcctctatca caaccccact tgcaccagct tcatgcaata 2067961 tatttgagat aggttcgacc gcttcatgtg ttgtgtgaat gcttaattcg gaccatttca 2068021 aaactaccaa ctcctcatcc aataattaat cgcctttaaa cgcgcgtttt accttgtcaa 2068081 agaaactcat ttcctgttcg tcaggcaggt ttccgctgac ttcggcaaat tcgcggataa 2068141 tgtctttttg tttatcagtc agatttgtcg gcgtaacgac gcggacgacg atatgctggt 2068201 caccctgtcc atagcctctg acattttgaa cgcctttgcc tcttaatctg aatttcgttc 2068261 ctgtttgtgt accggccgga attttcaatt tcacttttcc atgcagcgtc ggcacttcta 2068321 cctcatctcc aagagcagcc tgagcaaacg ttaacggcat ttcacagtaa atatcatcgc 2068381 cgtcacgctc gaagaactcg tgtgcgcgta catggaacac gacaaataaa tccccggcag 2068441 ggccgccgtt tattcctggt tcaccctgtc ccgagagacg aagctgctgc ccgtcatcta 2068501 caccggctgg aattgtcaca ttgattttct tgcgtttttt gatttttcct ttgccgccgc 2068561 agtccgcaca tttgttttta atgattttgc ctgtaccttc acagtggtgg cagacccgtc 2068621 tgttaacgac ttttccaaac ggtgtatttt gctccacgtt taactggccg gagcctccgc 2068681 agtgggagca tgtttctgga tttgttccag gtttcgcacc tgagccttta catgtttcgc 2068741 acgtttcctc gcggggaatt tcgatggttg tttctttacc gaaagccgca tcctcaaacg 2068801 acagggtcat cgtatactgt aaatcagcac cctggcgcgg agcgtttgga tctcttcgtc 2068861 ttgtgcctcc gccgaatata cttgagaaaa tatcatcgaa accaaaaccg ccgaaatcgc 2068921 cgccgccaaa acctccgccg ccgaagcctt ggttagggtc agtgtgacca aattgatcgt 2068981 aatgcgcacg tttttggtca tctgacagcg tttcgtatgc ttcttttacc tctttaaatt 2069041 tttcatctga tccggcttct ttgttaatat caggatgata tttttttgac agcttccgat 2069101 aagctttttt aatttcatcc tttgaagcgc tcttacttac tcccagcact tcatagtaat 2069161 cacgcttact catctcgctt cactctcccg aatttctcac ataaattaga ttgtatcatt 2069221 ttgaattatg atttttcaat tccttttatc ccgggcaaga aaaaaagtca aagccaagag 2069281 atgcctgact ttgactttct aatcattgaa tcagattatg aaatgtgttc ttttcggtca 2069341 gctccggaag cggggctgac actaaaaaga acttattttt tgttttggtc gtcgtttact 2069401 tcttcgtatt cagcgtcgac aacgttgtca tccgctttgc cttcagcgtt tgctccgcct 2069461 tgagcttgct gtgctttagc agcttcttca taaagcttca tagaaagctc ttgaacgatt 2069521 gtttgaagct catctttttt cgctttgatc tcttcaaatt cgtttttctc aatcgctgct 2069581 tttaaagcgt ctttggcatc gttggctttt ttcacttgtt cttcgtccac tttgccttca 2069641 agatctttta atgttttctc agtttggaaa acaagctgat ctgcttcgtt gcggacttcg 2069701 atttcttctt ttttcttcgc atcagcgtca gcattttctt ccgcttcttt taccatgcgt 2069761 tcgatctctt catctgagag acctgaagaa gatttgattg taatgttttg ttcttttcct 2069821 gtgcctaagt cttttgctct tacgtttacg ataccgtttt tgtcaatatc gaaagaaact 2069881 tcgatttgag gcacgccgcg cggtgctggc gggatatcag taagctggaa gcggccgagt 2069941 gttttgttgt cggcagacat tgggcgctca ccttgaagaa catggatatc aacagctgtt 2070001 tggttatcag cagcagttga gaacacttga gatttgcttg ttgggatcgt cgtgttgcgg 2070061 tcgatcagtt ttgtaaacac accgcccatt gtttcgatac cgagagaaag cggtgtaacg 2070121 tcaagaagaa caacatcttt tacgtcacct gtgataacgc cgccctgaat cgcagcacca 2070181 agcgctacaa cttcatccgg gtttacgcct ttatgcgctt cttttccagt ttcttttttg 2070241 attgcttctt gtacggcagg gatacgagtt gatccgccga caaggatgac tttgtcgatt 2070301 tcgcttgcag aaagtcctgc atcttgaagc gcttgacgga caggacccat tgtgcgctct 2070361 actaaatgag aagaaagctc ttcgaattta gcgcgagtta atgtaagttc aaggtgaagc 2070421 ggtcctgctt ctccagctgt gataaacggt aaagaaattt gcgtagaaga tacgccggaa 2070481 agatcttttt tcgctttttc agctgcgtct ttcaaacgct gaagcgccat tttgtctttt 2070541 gacaaatcaa tgccgttttc ttttttgaat tcagacacca gatgatcgat gataacttgg 2070601 tcaaaatcgt ccccacccag acggttgtcg ccggcagttg aacgaacttc gaatacaccg 2070661 tcgccaagct caaggatgga aacgtcgaat gtaccgccgc caaggtcgta tactaggatc 2070721 gtttgatctt catctgtttt atcaagtccg tatgcaagcg ctgctgcagt cggctcgttg 2070781 atgatacgtt ctacttcaag acctgcaatt ttaccagcgt cttttgttgc ttgacgctca 2070841 gcatcgttaa agtatgcagg aactgtgata actgcttttg atactgtttc gccaagatag 2070901 ctttcagcgt atgatttaag gtgttgaagg atgatagcag acacttcttg tggagtgtaa 2070961 tcctttcctt caatttcaac tttataatca gtacccatat gacgtttgat agacataatt 2071021 gtgttagggt ttgtaataga ttggcgttta gccacttccc ctacttgacg ttcgccgttt 2071081 ttaaatgcaa caactgatgg cgttgtgcgg tttccttcag cgttagcaat aactttaggc 2071141 tcgccgcctt caagcactgc cacacatgag tttgttgttc ctaagtcgat tccgataact 2071201 ttactcactt gaataacctc ctgctatgta attattgatt cactttgacc atggaagggc 2071261 gaatgacgcg atccttcagc ttatagcctt tttgcatttc ctcaacaaca atgttggagc 2071321 cgtagttttc gtcttcagcc tgcataacag cttggtgcag attaggatca aattcctgcc 2071381 ctacagcttc gatggcttcg acgccttctt ttttcaaggc ttctacgagc tgacggtgga 2071441 ccatttccat tccctggagc aaacttttcg tctgttcatt gtcggcttca acctgaagcg 2071501 ctcgttcaaa actgtcaaga gccggcagca aatcagtcac gatattttga gaacggtatt 2071561 tttgggacgc ttccatctct aaacggctgc gtcgtttata gttttcaaag tctgcttgaa 2071621 cacgcaaaag tttgttttct ttttcctcaa gcaaaccttg caattcgtta atttggtttt 2071681 gaagaagttc gctttcattt gtttcttcct gctgttcatc agcggcagct tgttcttcaa 2071741 tgatttcttg ctcttctgtt tcgttttgtt caacggtttg tttttcttct gacattgtgt 2071801 tcacctccct caaagtgtaa ggagaaggac aggtgctgcc cttcgataaa atttgccaaa 2071861 attcccttat tcatcataca gacttgttaa tgcttttgac aagtccgaag tcacatgctg 2071921 aagcaggctg acaaccctgg aataattcat gcgggtcggg ccgataatcg caattgagcc 2071981 gatctgcttc tggtctacgg aataagaagc cgtaatcaga ctgcaatttt ccatctcttc 2072041 atagtcgttt tcttttccga ttttaatcga aattcccgtg tgcggggatt gaaccagctt 2072101 taaaacatcc tgttctttct caattaatga aagcagcgac cgaactcggg tgatatcatg 2072161 gaactcaggc tggttcagca tattgatttt cccgccaaaa aacaactttt caacgtgatt 2072221 tgtggaatga aaggttgaac gaagcgcgtc gagtatattg tcatagtttt taatgtgctg 2072281 tcttaggtac atgacaactt ctttaaatat gcgctcattc agttcatcca ttggaacgcc 2072341 gcttaaacgg tcgttcagta tatttaccag tttttcaata tcagacagat ccattttggt 2072401 cggaaagtta atcgttttgt tttccacatg ccccgtattg gtaacgagaa tcgctaccgc 2072461 catatcaggc tgaatcggaa tgatttgaat ctgtttaagg taattctcac tcaacttcgg 2072521 cccgagtacg atggatgtgt aattcgtcag atcggacaaa atttgcgctg atttttgaac 2072581 tgtcttctcc agctcgaaaa ttttctcttt gaagatcgag tggatttggt ccaggtcgct 2072641 tttcgtcaat ttgacgggtg acagcaaatg gtcaacatag taccgatacc ctttttctga 2072701 cggaacacgt cctgaggatg aatgggtttt ttcaataaag cccaattcct ccaagtcagc 2072761 catctcgttt cttattgttg cagagctaaa tgtgatttca tcttttttcg aaagagttct 2072821 tgatcccacc ggctgtgccg atttaataaa atcgttgatt ataacctgaa ggatcagcag 2072881 ctgacgattt gttaacatca tcatcacctc tgttagcact ctcaataagc gagtgctaat 2072941 tctataacaa aagtatcaaa ccacaagaaa aatgtcaatt ataactcacc caaaaaagcg 2073001 ccaaaaactt cattgcctaa taatttccct tgatgagtca aataaacggc agactccgaa 2073061 ttgtgaatca gccctttttc agcgaggtct tttaacacgc ttgggaaaag tccatccagg 2073121 gaacggccgt atttttctgc gaatcgtttt ttgctgacac cggctgtttt tctcaaacct 2073181 aaaaacattt cttcctcaat ctgttcttct gttgtcactt catgtgtatc tctgtacgga 2073241 aaaccctttt cagctatcag gtcaatgtaa tgcttaacag gtccgacgtt cactgttcgt 2073301 gtgccgccaa tatatccgtg agcgccagct ccgaaaccga aatattgttc gttgctccaa 2073361 tacgttagat tgtgcttaga ttccatgcct gccttagcaa agttgctgat ttcatattga 2073421 tgaatgccgt gagcttccat cttgctcatc actatttcat acatttcagc ttcctgctcc 2073481 tgcggcggaa gatgaagccg ccctttttgc atcaaattat aaaataccgt tttcggttct 2073541 acaataaggg agtaaacgga ataatgctca gcgtccaatg ataaagcagt gtttatggaa 2073601 tgttccagat gcttgagggt ttgccccgga agcccgaaca tgagatcaag actgatattc 2073661 tcaaaaccga tttcccgcgc tctttcaaaa gaggtgaata catctttttg cttgtgcact 2073721 cggccgattt tttctaacag atcgtcttcg aacgtttgca caccaaagct aaggcgattt 2073781 acgcctgctt cttttaatat ttttaatttc tctgcggaca aatcgtccgg attcgcttca 2073841 accgcaaatt ccgataagtc gcttgagggc tttagcacgc ggttgatcat atccatcagc 2073901 tttttaagct gttcctcaga cagggaggtc ggcgtgcctc ctccgataaa gattgttttg 2073961 agatcaggct gcccggtttt tgctattgta tttatcattt cctgttcgag tgcgtttaaa 2074021 tactcgtcga ctggctgact ttgaataaaa tatttattga aatcgcagta gtggcaaata 2074081 tgctcacaaa atgggatatg gatataagct gatttcaacg gattcacctt ctttacagaa 2074141 agaagccgca gtacaagact gcggcggctt ctattgtttt ttcggactgt cgtccatttt 2074201 cagaactgcc ataaatgctt cttgcggcac ttcaactgag ccgacctgct tcatacggcg 2074261 ctttccttct ttttgttttt caagaagttt ccgtttacgc gagatgtccc ctccgtaaca 2074321 tttagccaat acgtttttac gcattgcttt tatggtggag cgggccacga ttttctggcc 2074381 gattgcggct tgtaccggaa cttcaaactg ctggcgcgga atgagttctt tcagtttttc 2074441 aacgatcact tttccccgtt catatgcgta atcacgatgc acgataaagg aaagggcatc 2074501 gattttttca ccattcagca taatgtccat tttcacaagc ttggacggtt tgtagccgat 2074561 cagttcataa tcaaaggacg catagccttt agtgcttgat ttcagctgat caaaaaactc 2074621 atatacgatt tccgctaatg gcatatcata aatgatgctg acacggtttg cgtctaaata 2074681 ctgcatatca atgaaattgc cgcgttttcc ttggcaaagc tccattacag cgccgacata 2074741 gtcattcggc accatcatcg tcgcttttac gtatggctcc tcaacccttt cgatcttttg 2074801 aggatccggc atgttggacg ggttgtcgac aacgaccttt tcgccgtctg tcatatacac 2074861 gtcatagata acgcttggcg ctgtcgtaat caggtcgatg ttgaactcac gctcaattcg 2074921 ctcctgaatg atctccatgt gaagcatgcc taaaaatccg cagcggaacc cgaatccaag 2074981 cgcttgcgaa gtttccgctt catattgaag ggaggaatca ttcagctcaa gcttttcaag 2075041 agcttccctt aaatcattat acttcgctgt atcaatcgga tacaaaccac agtacaccat 2075101 cgggtttagc ttgcggtatc ccggcagcgc ttcttctgca ggattggcag cgctcgttat 2075161 tgtatcaccg acacgtgtgt caccaacatt tttgattgag gcagtcagga agcctacatc 2075221 accgaccgtc agttcatttg tcggagttgc tttcggcgtg aacacgccca cctctgttac 2075281 ttcgaattct ttgccggttg ccatcatttt gattttttgt cccggcttta ccgttccttc 2075341 aacgactctg atataagcca cgacaccgcg gtaggcgtca taaagcgagt cgaagatcag 2075401 cgctttgagc ggcgcctccg gatctccggt cggagctggc accttttcta cgatttgttc 2075461 taaaatctcc tcaatcccga taccggcttt tgctgaagca agcacggctt ctgatgcgtc 2075521 aaggccgata acgtcttcta cctcttggcg cacacgttcg ggctcggcgc tcggaaggtc 2075581 gattttattg atgaccggaa ggatttcaag atcgttgtca agcgctaagt agacattggc 2075641 gagcgtctgc gcttcaatcc cctgggctgc atccacgaca agaatcgctc cctcgcaggc 2075701 agcaaggctt cgggatactt catacgtgaa gtcgacgtgt cccggcgtat cgattagatg 2075761 aaagatatat tcttctccgt cttttgcttt atatttaagc tgaacagagt ttaatttaat 2075821 ggttatgccc cgctcacgtt caagatccat agaatcgagc aattgttctt tcatttctcg 2075881 ttgagtgatt gccgacgttt tttctaaaat acgatccgct aaggtcgatt ttccgtggtc 2075941 aatatgggca atgatagaga aattccgtat tctcgattgc ctctctaaac gcttttcttt 2076001 atctgtcaca atctatcact cctactatta aacgcaaaat acactagctt agattatatc 2076061 aataggattg taaagattca atgtaaaaca agaaagagaa aagttcccta tcatatctgg 2076121 gttgcttttc tctttcacgt acttattgat tcatatcccg tatccattca tacattgact 2076181 gggcagtatt ggttacggtg tccgaaagcg cttttccggc ttttgaaaac atattgaatg 2076241 tctccacctt ttccagctct ttttgttttt ctactaaatc ttttgccgtg actgtttctc 2076301 ctaggattga ggcttctttt tcattatctt ttccgtcggt gagcgtaaac gcccccttca 2076361 gtgaagggtc atgatagcct ttcatactca gcatcccgtg gtttgcctgc tgcatgccga 2076421 acagaacgcc taaaaacatg atcgtgacaa gcagtaagca ctttccaaag tatgcaatca 2076481 aatcaaccac ctatttctta ttgttttttc gtctccccgc tcgctgcgtt gaccttttca 2076541 gcatcccagt acatttcgct gaatacgtcc gcggccgcgt tagccgcacg ctgcagctct 2076601 tcgagattat tatccactcc gccaaactcg agcaaaagcg ctctatcggt taaatcctga 2076661 ttgtaaacac cattatcgcc tggcgagcct ttggaaaaga cacctgtgct aagtccgggg 2076721 tattttttct ccatcagttt atgaagctca ctcgcaattt tatagttttc ttcgaagttt 2076781 ttgctttttt tcccgacgac aaaggctacc ctggcatagc ttttcccttt aatcgttgcg 2076841 gttgtgtctt ttttgcgccg agagtctctg tggatgtcaa tgatatattg cagatttttg 2076901 tttgaagcga gggcgtcttt cacgaccggc cttgattcat cataggacct ggcatagttt 2076961 aagccttttt tattcaattt tgactgtata tcggttttat tcactgtggc tccgattccc 2077021 tgggattcaa gcgcttgtcc gaacatatct cctacaagcg tgacattggc tttagaatgg 2077081 cgcgccatgt caggatcggt ctcgcctttt aatagaggga gatatgattc cgtattgtgc 2077141 gtgtgataga taaacacgac ctttttatca cctgttgttt gtttcggcgg atctttttgc 2077201 gcattatctg attgcgtttg ctgtttttca atctctgcca aattcgcttc tctttcttcc 2077261 tccatcacct tagacggcgg cggcgattcc gcaggcatat tcgtataatc cgttccttgt 2077321 ccagctaaca aaatctcggt atcaaattgt gcaaatcctg gcagctcccg accgagaaag 2077381 ctccgcggat cttcgaggtt aatgctcgtc gccagcttta aagaaagacg agaaagatga 2077441 aatgagctgt ctgtttgaga gaggtcagaa gcgaaataat ggttttccat ctgcagcaaa 2077501 tgtgcaaata cgtcacccgg caattcttca gcaatcccat aaaaagagtc agacgacggc 2077561 ctaagttccg gccggagaga cgtcagcaca ccggatagaa caaaaatcac gataaggctt 2077621 acgataaata gaaagatggc ttttaccgct ttccctccat ttaccgcaac aacaatctgt 2077681 ctgtttctgc gtttatttct cattgaatcc ctccagcgct tgtctagtaa ttactctatg 2077741 aacaagctag aggaagtaga actgtttagt gattgtagga gcctttgttt tcttgtgaca 2077801 ctttttcatg aagcgctgtg tttaatccgt tcgctaaaac atttgccata tcgtcgataa 2077861 atgaatcgac ttccttcggt gtaaccatta agttgtgccc taaaggcgaa agcacctcgt 2077921 gaatgagctg ccgtttttca tcttcttgaa gggttccgac aatacctagg aacgattggc 2077981 gctgcttttg atcgggaaga tcgtcttcag tgagcacttt ctttttccca aacgtcatgc 2078041 ctgccggaac aagcgatctt gatggcctgt tatccttcat ttctctgcca aaatgtttta 2078101 atatgtagtc caccgtgtcg ctggcaattg tcacggcatc aactactgtc ggaacaccga 2078161 tagcaatcac cggaacacca agcgtgtctt tgcttaaatc ttttcgttta ttccccactc 2078221 cagaccccgg gtgaatgcct gtatccgata tttgaatggt tgtgttgacc ctttccaccg 2078281 cccgcgccgc caacgcatca atggcgatga caaaatcagg cttcgattgc tcaatcacac 2078341 ctttaataat gtcacttgtt tcgattcctg ttatccccat tacacccggt gcaaaagcac 2078401 tgacaggcct gtaaccctcc tgtacgtttt ccggctgaag cttaaacaag tgccttgtta 2078461 ccaacagatt ttctactgcc atcggtccaa gcgcatcagg tgtcacgttc cagttgccga 2078521 gcccaacgat caaacagctc gcatcttttg agatattaag gttttcaaga aaagctgaga 2078581 attcctccgc aaagacagca gagaccttct cctgcatttc cgaatcattc tccctgattc 2078641 cctgtgcttc aagcgttaaa tagcgccctt ctttttttcc cgaaagctct gcgccttcct 2078701 ttgtaacatc aactgtgcgg attttaatgc cgccgtgatc acgctctttt tcaataaagc 2078761 ctttaatttc ttttgtcggc acagcctgct gattggccat tgcttccttc gtttccactg 2078821 ccaaatcggt ccgtatcaaa tactgattca catccagctc actctttttc atacaggggc 2078881 ctccttcaca ttaagtacct atattgttgc catttgctga ataaatcatg ctaaaaagag 2078941 aaccttcaat gaaaaatact ttacatttat attgcaatct aaaggtgtgt ttgatagaat 2079001 acaatttgtt ctattgtgaa gaagatttaa ccttaagaca ctgtgctaca ggttgtatct 2079061 taggaggtga aacacatgcc aaacattaaa tcagcgatta aacgtacaaa aacaaacaac 2079121 gaacgccgcg ttcataacgc gacaatcaaa tctgctatgc gtactgcaat caaacaagtt 2079181 gaagcttctg ttgccaacaa cgaagctgac aaagcgaaaa ctgctcttac tgaagcagct 2079241 aaacgtattg ataaagcagt gaaaacaggt cttgtacaca aaaataccgc agctcgatac 2079301 aaatcaagac tagcgaaaaa agtgaacgga ctttctgcat aatataaaaa cgatcctcaa 2079361 taatggggat cgtttttttc atttcttttt aacagctgta aaaggaacag ttcgagcagg 2079421 agctgcttgt cctttttccc ggttttcatc tcatagtcca tgacggcaag ctgttcaata 2079481 attaaacgga gctcctcctc tgaaaaaagc cttgcttgat ccatcgccag ctttacccga 2079541 aatgggtgaa cttttagatt agaagcgatt tgtttttgtc cgtatccctg ttccgcgaag 2079601 tacttcgtct gcagaatcag ccggaactga ttcgaaataa gcgccataat tttgatcggt 2079661 tcttcatttt gttttagcaa atcataaaaa atttgcagac tctctgttcg ttttcggttg 2079721 acgattttat tgatcagctc aaaaatattt tgttcaaggc ttctagcaac aagcattttt 2079781 acatcatcca gcgtaatttc ttcacgatct ccaataaacg tgcagagctt ttgaatctcc 2079841 tgaaaaatcg atgacagatg accgttcaca agcagaacca aatgctccgc cgcttccgtg 2079901 ccgattgttt tctgctctgt ttttgcaagg ttgacagtaa agtctgtcgt ttcctttgca 2079961 tttaattcct tcgcctccat cataaacgcg tgcttcttta acgctttcgt cagctttttt 2080021 cgctcatcaa gcttttcata cggagcaagc aggacaaaga ctgtgtaagg cgcaggtgat 2080081 tgtatatatg attcaagcgc actgacgttg tgctcaattt tttctttttt cttttcacct 2080141 gttaaaaaat atggattttt cacaatgaca agacgccgct cccccataaa cggaaacgtt 2080201 tcagcatctg caatcgcttg atccagcggg tcctcttcca gatcaaaaac ggacagattg 2080261 aaatcctttg tctcctgatc aacgaccgtc tgtctgatcc tgctgacggt ttcttgcagc 2080321 agatatgtct cttttccgta taaacaataa accggatgga cctctccttt tttcaggctt 2080381 ttccacacat caaataccat tgttgtacga cttcctctct ttcatcatcc ccttctatcc 2080441 taaattgagt ttgcaaaata gtaaagagga agcctgactg ctgcttcccc atttatatta 2080501 aacgcctgtt cgcaagcccc cgggacagct tgtaaaaagg cgataatcac cagaacagaa 2080561 aacgttacct tagcttctag atttttcaaa acaattccat tatacttaag tcagtcagga 2080621 gggataaagt tgaatgattt tgaaaaaaac gttcaaagca aacgaaatga tgctgtagat 2080681 tcagctgttg gttttgttgt gtccttcgga tttttcgcct tcttgtttgt catggcaacg 2080741 gttattcacc tagttggttc ataacagcga ctgcccgggc tgctgatttc tcggcagtct 2080801 tttttagttc gtctctgtta tatctgatgt atcatatgga ggatagacag aaaaggttcc 2080861 aactctgttt ttgtatctat attggatcgt tccgttttga tctgttcgca gcacgcggat 2080921 agaatgtctc tgtaatagtt gcagaacttt ttgatgagga tgatggtacc gattgttttt 2080981 cccggctgag ataatggccg ttttcggctg aagctgttgg atgaattctt caccggtaga 2081041 gcctttgctc ccatggtgcc ccacctttaa cacatctgct tttatattcg gaaacacgtt 2081101 catcacctct tgttcccctt ctttctccag atcacccgtc aagatccagc tcataccgcc 2081161 cgtctccatc cacagaacga gagatgaatt atttttgctt gccggatcag gtgcttccgg 2081221 tgacagtaca tggaactgca aatcctttat ttgcaacaca tcgcctcgct tcacctcttc 2081281 aattgccact ccctcttccc tggctgcctg cagcactttc tcatctttag gttcagaaac 2081341 gaaccctttc ggaatcacga ggcgctttac tttatgatgc ttcagcagaa tctccgcctc 2081401 tccgatatga tcttggtcag cgtgcgtcag aattaaagcg tcaagctgct tgattccctt 2081461 agcagttaaa aacggaatca gcaccttttc ccccagtgaa aacggatgct gtttttcgcg 2081521 ccaaggctct gacgagtaag acaaagtgcc gccggtatca attaagacac gaccccgctg 2081581 atgcggagca cctacaaaca tgctgtcacc ctgtccaata tctatcatat ccacttctcc 2081641 ttcggaacta agacacggat atataaagag cagaaacatc accgtgcagc aaatgcctcc 2081701 ggttaccatc aactgcgaca aggagcgttt ttcaatcgcc ataagcaata ggatgatcgt 2081761 gactgtgaat aaaaaaagca aaacaggtgc aggatgtgcg atcataatcg tgaacacatc 2081821 aacatctgca atgtttgtga ttaacctatt gatccagctt atcaataaat caaaccagct 2081881 gaaaaacaat ctcccaaacg aagcggaaag acttaataga agaacacctg ctacagctcc 2081941 cggcaaaata cagaaggtat aaaatggtac catcaacata ttcatcggta cgctgatgat 2082001 agaaaactga tgaaaatgat ataggagaat cggaagcgag cccagctgag cgatgagtga 2082061 tacaattgtc agctgcccca aggaggtttt aacctgctga aaaatagaag aggatagaat 2082121 taaagaaaaa ctgacggcga acgatagctg aaaaccggct tcaaagagat gataaggatt 2082181 gaagagcaga aggacgatgt acgaaaggca aattgcagtt gcagagcgga cacgccattt 2082241 gacaagactt ccagctaagt aaacacccga catgagagcg gcgcgtagca ctgaaggagc 2082301 agcgccggtc aacatcacat agagcggcag aaataacagc aacagaattg acgccttttc 2082361 tctagttata ccaaggcgga tcatgatata aaacaaacct gctgtcaaaa tccccacgtg 2082421 gagtcctgat attgccaaga gatggacaac accaagcttt tgatacgcgg taagcacttc 2082481 atcctccacg taaaatctgt caccaactgt aagtgcctgt acaatccctg tcgaatcagg 2082541 aggcagaagg ctgtttgtga atgatatgat atgttttctc aagctgagca ccttgtactt 2082601 gaaattttca ggttcgctgc agttttggat agacgtgaca gagtagttcc aatgaatatg 2082661 ctgccgataa agatactcgt tataatcaaa tgcacccggc acagttgcgt gattcggttc 2082721 ttccaatgta ccagtcaact cacatgacat tcctggttct atgtataaca gctgttcttt 2082781 ttcaccagca gactgaatgc gatacgcagc agcccatttt tccttatcag gtgtctcaac 2082841 catcatagac atacggtcgc cgtcaatttt gggaatagtg tcaatcactg ccttgaattg 2082901 ataggttccc tgccgatagg aagagacatt ctgagaatct gtgactgcat acagtacaaa 2082961 aaacaatata aaagagaaga aacaaacaat aataagaaaa gcgtgcctcg ttttgattaa 2083021 aatgatgagg agaaagagga tgaaaagaaa aatagcgggg aaataagcgg cggcagtaat 2083081 tccagccgtt gccgaagctg ccgccatagg caataataag cgcgaattac gcattcatca 2083141 cacgtagctc gtgaaaagtg tattcgcctg ttcatgtatc tttttcaatt cttcctccgc 2083201 taaaccggca tcagccaatt tccctattag acccgctaca aatgaaagct tttctctgtt 2083261 tttcagatca acgatcattt catcgagttc aacctgttca acagttacac ccgcctgttc 2083321 aaataattcc tgcgcatacg gatgtgtttt gtaatcctca gcataataaa ccgttttgat 2083381 accagcttga ataatagatt tgcagcattg aatgcacgga taatgcgtca cataaatctc 2083441 ggctccatca gtcggcaccc caaacttaga gcattgaaga atcgcattca tttcagcgtg 2083501 aatggttctt gcgcaatgat catctatcat taagcatcct tcatctgcac aatgtacgcc 2083561 gcccgcgatt gacccattgt agcctcctgc tatcatgcgt ttgtctctga ctatagtagc 2083621 gccgacagat aatctcggac atgtgctgcg cagcgccaat aaatggcttt gagccataaa 2083681 gtattgattc catgaaattc gttccacgtt gttccctcca aatgttgtgt tgcctgacct 2083741 ttagtttacc tatcataatg catgaccgtc aaatcacttt actgtaatgg aagactttat 2083801 tttctcaaat gacttttcac ctattcctga aaccttagtg atatcttcaa ttgtttggaa 2083861 acgaccgttt tcctcccggt atgcaataat agcttcagct ttggatggcc ccacccctga 2083921 gatgccttgt aactcctcta aggttgctgt attgatattc accagcgctc ccttccctcc 2083981 atcgctttgg acagaccctc cgccaccttg ctgcactgct gtttcctctc cctttttcgg 2084041 gatgtacacc actgtcccgt cctgcagaat ctccgccaaa tttacttgcg cttcgtctgc 2084101 ttgttcactg gtcccgcccg ctttctcaat tgcctgagat actctgtccc ctgttcgcat 2084161 ttcataaacg ccaggatgct gaacagcacc tttgatgtct atcacaattg tttcgtttga 2084221 ctcgtcgttg tttgcttcct gctttaccac tgtattttct gtctctgttg gtacagcttg 2084281 cttcaccggc tctttatttt tccctgtggc cagaaagatc ataatcgctg tgaaaacagc 2084341 cgcagaagcc gctaaaataa ttgctttctt atgctgattc aaccaattca tcgtgcatgt 2084401 tccccgcttt cgtcatattt tattttcata acacatatgg tttagaggat aatagctcaa 2084461 aggaggggaa accattgaag ataggcttta tcggcacagg aaatatgggt acgatcctta 2084521 tcgaatcatt tattgaatca aaagcggccg atccctcaaa catgacaatc acaaaccgca 2084581 caattgaaaa agcgttgcac ataaaaaacc gctacaacag cataaacgtt accgaaagtc 2084641 tcgaaaagct cgtttctgaa aacgagatga tttttatttg tgttaagccg cttgatatat 2084701 atcctttact ggcaagagcg ttaccttatt taagaaaaga tcatattctc atttcaatta 2084761 caagccccgt tcaaaccgaa cagctcgaac aatatgtgcc gtgtcaagtg gcgcgagtga 2084821 tcccaagtat tacgaacaga gcgctggcag gtgtttctct cgtcactttc ggcacaagct 2084881 gcggcgaatc tgcaaaagcg aaaatcaatg agctgatgca gcatatctct catccgctgc 2084941 aaattgaaag tgacatcacg agggttgcat cagacatcgt aagctgcggc cccgctttta 2085001 tgagctatct gattcagcgg tttatagatg cagctgtttc ggaaacatca gtgtctaaac 2085061 aggacgcgat tttgatgtgt aaggaaatgc ttgtcggaat gggaaaactg ttagaaaccg 2085121 aattgtatac cctgcctgca ttacaggaaa aggtttgcgt taaaggcggt gtaacaggag 2085181 aaggcattaa agcgctggaa agcggtgtgc aggatatgtt tcaccgggta tttcaaaata 2085241 ctcatatgaa gtacgaggag gatatttccg cagtgaaaaa gcagtttcat gtgtagacga 2085301 gtatgtcata cgttcgtctg tactgcaaaa gcataaaaaa gcattttaaa aaaccatcgt 2085361 tttaggaaac gatggttttt gatttctgcg ccttgaaaaa gaggcgttct gattgtgctg 2085421 atggctcggt atccgtaaaa tcagctgtca cgcgatggag ctgaaagccg cagttcttaa 2085481 gcatttcttc gtattcttcc accgggaacg ttctttgctc gtgtgtctca tcaaaacgat 2085541 catacgcttc tccgttccac acaaaaaacg acatatcatg aatgacagaa agctcgtcac 2085601 ttccggcaaa gctctgccaa atatagctga tatcttcgtc ctggtcagca aatgtgctat 2085661 ccggaaagac ttccgcaatt ttaaaagatg aatgaacatc aaacagcagg atgccttcag 2085721 gctttaatac ccgaaaaaca cttttaaagg tttcgatcac atcatttttt gtttttaaat 2085781 aatttaatga gtcacagcat atcacaacag cgtcaaattg accgtcaaag ccggtaatct 2085841 ctctcatatc ctgctgaaga aataaaatag gctggctact cgataccttt tgctgggcga 2085901 aagaaagcat ctcttcgctg agatcgatgc ctgtaacctc gaagcctttt tcggcaagcc 2085961 ggatggagat ttcccccgtg ccgcatgcca gatcgagaat acggcctttt tccgggagag 2086021 atgcttcaat ccattttgtc cattgatcgt aaggcgcgtg tgacattagc tcgtcataca 2086081 cgcttgcaaa gccttgataa atcattgatt cattccaaag tcaagatctg cgagcggagc 2086141 gtctccccac agcttttcaa ggttgtagta gcttctttca tccttgtgga agacatggac 2086201 aactacatcg cctagatcaa cgagaaccca tcttgcttca tcaaagcctt ccatcttttt 2086261 gacttgaatg ccgttttcat cagcttgatc cttgatttca cgggcaatcg cctgtacctg 2086321 tttatctgaa tttccgtggc agatcagaaa ataatcagca accagagaaa taccttccat 2086381 atccagtgct aaaatatcct ctgcccgttt atcatcgcaa gccgcagctg cgatctttaa 2086441 aatggacttt tggttcattc acaaattcct cctgttcagc tgccagacac aagccagtta 2086501 tacgttaaaa atgtgtctgg aaaaaccggt tgattttttt tcataagaaa aaccattgta 2086561 tttttaatgg actgaatcag cgcttgattc aaatctgtct cagcaagctt acgcacctca 2086621 tcgacaccgg gaaatgcccg gtttggctca atgtaatcgg caacgtaaat gactttttct 2086681 aaaagtgtca tgccggggcg gcctgaggta tgatacctaa tggcgtcaag aatgtcttca 2086741 tcttgaaccc ctgcctctct ttggaccaaa taagcgccga ccggagcgtg ccagagctcc 2086801 ggattatgat ccaataaatg cgcaggcatt ttttcacgcg caataatttg tttcatttct 2086861 tctttcgggc ggaatttggc gtaatcatga aagattgccg ctatttccgc ttttttagaa 2086921 tcggctccaa aacgctccgc aagttcgatc gccgtgttca tcacgccaac cgtatggata 2086981 tatcggtgtt cggtcaattg ctgcttcacg catgcaagtg cctcctcacg attcatataa 2087041 accattctcc tctacatact tcttcacttt atcagggatt aagtagtcag tgggcttctt 2087101 gcttttaaac cgttccctta tcatagttga tgatacctca aattccggaa cgtctgcaaa 2087161 gagaagcgga taaggggttt caacatgaaa accggggcgc tttactccaa taaattgaat 2087221 gaggttcagc agctcgtcca gcttatacca tttcggcaaa tattcaatca tatcagcgcc 2087281 gataataaag aacagctgat catttggata acgctgcttc agtaaagaaa cggtatcaaa 2087341 ggtatatgat ggcccttctc tttccatttc aacaagctcc agcttaaagg acggattaga 2087401 ttgaattgca agctttagca tttccacgcg atgaaagctg tcggtatagt cttcgttctg 2087461 tttatgcggc ggaatttgat taggcataaa ccaaatttca tcaagccccg cctggtacag 2087521 cacctcattc gccattaaga ggtgaccatt atgcggaggg tcaaacgtgc ctccgaaaat 2087581 tccgattttc ttcatttcaa ccacctttaa ggaagctcga tttgtttatt ttcctttgat 2087641 tccttatata acacaatcgt attgccgatt gtctgcacca attgagagcg gcttcctttt 2087701 acaagagctt ccgctacatc gtttttatcc tcttcgcaat tctgaagcac gctgacttta 2087761 atcagctctc tcgcttcaag cgcctcagca atttgtttaa tcatgttgtc gtttactccg 2087821 cctttaccta cttgaaaaat cggcgttaaa tgatgcgctt ttgaacgcaa aaaacgtttt 2087881 tgtttacctg ttaacattct gttcctccta attttcctat tacaatagat ctcatttttt 2087941 caatattagg ctcttgtcca gtccacaatt ggaaagacaa tgctgcctgt tcaacaaaca 2088001 tgcccacacc atcgagtgtt ttcaagcctt tttggcttgc ttcttttaaa agtgccgtct 2088061 gtattggatt atacacgata tcacatacga cggcactgct cgcggcacgc tgtaatgaaa 2088121 gcggcacatc gtccacgttc ggatacatgc ccacagacgt tgtatggatg ataacatcat 2088181 actgctcaag acgttcttct gcttctttta tgcttaatac ttctttattg tgaaacgagg 2088241 gagtagcttc tgtaagccgc tttgcttttt ctaacgtccg gttgcaaatg tcaaattttt 2088301 tcggggtatt tcggacaatt gttgtaaaaa tggctctcgc cgctccgcca gcgccgatca 2088361 ttaagaatga cagttcagag atgggcttgt ctaatacctt cattaatgac ttcacgaagc 2088421 cttccccatc ggtattgtat ccgacaagct tatctccctc tcttctgacc gtgtttacgg 2088481 caccgagcac ttttgcactc tcatcaatat gatccaaata atccataatg gaaaccttgt 2088541 gcggaacagt cacattgatt ccttgtacgc ctagagctct tattcctttt accgcatcct 2088601 ccagatcatt ctcttctacc ttgaaggcat gataatgtcc gtcaagcccg aggtctttca 2088661 atgatgcgtt atgaatatca ggtgacatag aatggccaat aggatttccg ataaccccgt 2088721 acagcttttt catacacctc tccccttttc ttaaattaat gaacgccgaa caaatacatg 2088781 aacgcctttt ggcgcgtatg cagttacctt tttatcagcg tcatggacag taacccagcc 2088841 taacccagag aaaacgatat ctgtcttttt gtcttttatc gtaaacgtat gggcgaccaa 2088901 ttcaggaaac tcatccattt catctttacc cggaggtgtg agcaattccc ctgcatgctt 2088961 ttcataaagc gcgtctgcat tttcaagttt tgttctatga atcatcagct cattcggcat 2089021 atagcaaata aaaggagatc tttccccaga cacataatca aaccttgcaa gtccgccaaa 2089081 atacagtgtt tgctgatcat taagctggaa tgtgcgaggc ttcagctcct ttttaggaga 2089141 taatattttc aggtcctttt tattgacata atgcgccatt tgatggttgt tgataattcc 2089201 cggtgtatca taaagcgatg aaccgtcatc cagcgggatt tcaatcgcat caagggttgt 2089261 gccaggaaat tgggatgttg taataatatc ttcttcacct gacacttctt taataatccg 2089321 gttaataaag gttgactttc ctacatttgt acatccgaca acatagacgt cttttccgtt 2089381 gcggtaatgc tcaatcgcgt caattacttc tctgattccc tggccgcgac ccgcactgac 2089441 caaaaatacg tcaaccggtt ttaagccaag ctctttcgct tcacgcttca tccattggat 2089501 cagacgctct cttttcagtg acttaggcaa aatatccgct ttattgccaa ctaataagat 2089561 agggtttccc cccaccaagc gctgcagccc attaatccag ctgccgttaa aatcaaaaat 2089621 atcaacaatt tttacgacca gagagtccgt ttctccaata ccgtgaagaa tgttcaaaaa 2089681 atcatcatca gttaaggaga catcttgtat ttcattatag tttttcagtc tgaagcaacg 2089741 ctggcaaatc acattttctt tcgtaagcga tgcaggcggc gcgtacccca aacctgtttt 2089801 gtcctcggtt tggatcgtaa ctccgcaccc gatacaaaca accttttcca tttcttactc 2089861 ctcccactga atgtgccctt ttcgtttgag agcactcagt attctgcgtt cgacctggcg 2089921 gttaaagcgc gtaatgaatc cgtcagagga agcgactggc acgaccaaaa tcgtatggta 2089981 gccgtttcgg tttcccccga gtacatcggt cagcagctgg tctccgatga caacgcagtc 2090041 ctcttttttc agctccatat tgcgcaccgc tctattaaag gctttaccca tcggttttct 2090101 tgctttatag atgaatggga ttccaagcgg ttctgagaaa agtttcactc ttctttcgtt 2090161 attattagag acaattgtca ctttaatgcc gtgttccttc atttcttcaa accactcgat 2090221 caatcgcggc gtcgcgttcg gcctgtccca ttcaacaagc gtattatcca ggtcagtaat 2090281 aattcctttt acatttcgtt cctttaattt ctcaggtgta atatgaaaaa tattttttac 2090341 aaactcgtca ggtaaaaaaa acttttttaa caaaacccgc acccttccct ttttctttct 2090401 ttcaaaatga ttgtcgaaaa aaatcgaact tgcgcctaaa gaaaaactga gcaaaaaaat 2090461 ttcgacaaaa attgggtttc ttcaccaggt gtggataaat ttacacacac tatccactct 2090521 tattacatca ctctttagac aaattataaa cacgatactc acaagttatc cactttttgg 2090581 tgtggataac agaacgattg ttcttatatg catttcatgg tagattaaag ataacttcaa 2090641 cctcagatga atgcaactta tcattgtatg cgttaaaatc atgaatgatt ccaactttta 2090701 aggaggtgcc tctcccatta attgggttcc tagcatgaga aaactgtctg atgaattact 2090761 aatagaatct tatttcaaag ccaccgaaat gaatttaaac cgtgacttta ttgagttaat 2090821 tgaaaacgaa ataaaaagaa gatcgctcgg acatattatt tccgtatctt cttaatagga 2090881 atttgtctat tttttccggg cgtatttcct ttttttactc agatgactga tattatatca 2090941 ctttggctgc gcgctttact actattttca gcaaaaaaca cccctaaaaa gaggtgtttt 2091001 aaagggccgg ttattatgct aaccagtata tgccgcccac aacaaggaga acaacaacta 2091061 aaacaacaat aaaagcgtat ccatatgctc tgcctgcgcc atacatgtga agcgcctcct 2091121 taataaggtt ttataacagc ctatgtagga gaaataaatc ggactaggcg gttgtccggc 2091181 tcaacgctgc aggatctgcc ccgcgaacta atttattaat gttcaacaac agaatttcgt 2091241 ctattggcaa taaagaatcc acaaatcatt gcaagaatgg ccatcgccca ccagaacgtt 2091301 gagatcgcct gatcatgatc gatgataatc aaacgaatga cagctgtgat gccaatataa 2091361 atgaagtagc gaagcggaaa atgaaagtct gatttgaagt atttgataat caaagcaatg 2091421 aactcaaagt acatgaagaa tataagcagt tctccaagca tctcataata gctgtccact 2091481 ttgttgaaca gtgacttgta tacgaatagc acaatgtacc aagtctcgct gatcagaagt 2091541 gcgcttaagg ctaacgccag aaagaacaga cagacgttga gaagcgcttg taacaggtaa 2091601 ggcacctttt tgaatttgtt agaaaatctc atcatgttgt ctcctatttc aatatattcg 2091661 tggtttttat tctcagccta catcttggtg ttccaaaatc gtagcacaat gtagtactta 2091721 gaattctttt gtatactgtg aaactgtccc tgcatgcggg acatcattcg cgcaatgctt 2091781 ctttcaccga gtccgttgct ttccggtgtt atatctgcaa gtttaatcgt attgctaaca 2091841 tggatctcaa atatctcttg atccgataca aacgtgatac tgattttttc ttccggatct 2091901 gcgtatttca ataagtttga catcacatta tcaaatacac gaccaagctc ctccaaattc 2091961 acgttaatat aggtttccgg cagctcgcct gaaatatgga cccgaaaatg ctcctgatga 2092021 aggatagcaa tctgatctga tattagatcg tagatcactt ctttcactgc aacggtctcc 2092081 agatcggcct catattcctt gttcagcagg aaatacgcaa acagattgtc agacaagctt 2092141 tttaattgca gtgctttacc ataagcattg gctacatacc gatctttgct ggcacccgct 2092201 tcgcctccct cttttttggc aaactccaga ttcatgatca gcgacgtcag cggtgtgcgc 2092261 atatcgtgcg acatttcggt aaccaggctg cggctctcag cttgcaattc ctcgatagct 2092321 ttaagtttat ccaggaaagc tttccgcaga tcctcaatgc tctttgcaat catcgctaat 2092381 tcatcatgcc cttttatcgt catctcgtag tccagttcgc ccccttcaag aatatgaatc 2092441 tcttgatgaa tcgttttaag gtagcgaaga ctttggcgaa ttccgaagag aacaatgatt 2092501 aaaaagatga gggttgcccc gagcaaatcc aatgcaaagg ccagatcata atatcgggaa 2092561 gagtagaaac cgtcgataat gactcgtcct tcaccatcgc taaacttgac aggatgtgaa 2092621 tgattttgag cgtactgagt cagcttttcc tttccataat ccgattcgga ataaatagaa 2092681 tcatattgca gctcctgatc cttgaatatg gtgaggttaa tgtaattttc ttttttgacc 2092741 cactcgccaa acgcttttct atctgatgta gacaactcat tttctgaaac gtacttgctg 2092801 aatttttgaa tgtatcttgc tgactcctcg tgataatact cttccgaact cagatatccc 2092861 tcgatcagat catctgtgat cttttgcaac gtcagaaaga tcacaccact cacaatcgca 2092921 gcaaccatta tcagcaaagc cagttttttg gttagcgtaa atttaagatg cgccaaatcg 2092981 atatcctctt ccccattcag tttttatata aaccggacgt gccggatcat cctcaatttt 2093041 ggagcgcagc ttccgtatat gcaccatcac cgtattgttg gaacagtaaa agtaaggctg 2093101 tccccacaca ctctcatata tattttgggc agaaaatatt ttgttgcgtt tgttcatcag 2093161 aagtttcagg atacgatact ccagatctga caacttgatt tgcttctcct ctttccacac 2093221 ctcattaaat tcttcgctca ctcttagttt gcccccgata agaaatgttt cttcctgttc 2093281 cttcttttcc tgatagatag tatatctgcg taattgagca atcactctag cgtgaagttc 2093341 ctcttccgag aatggtttag tcatataatc atcgccgccg gcgagtaatc cctcagtttt 2093401 atcgagtgta ctcgatctgg ccgtcagaaa cagaatcggg acgttagagg atttcctgat 2093461 gtgctgacat gtttcaattc ccgaaatgcc tggcatcata atatccaaaa taaccaaatc 2093521 aagcgagtca ttcacaagtt gcaatgctcg ctttccatcc ttggctctta gcacctcgta 2093581 acctgcacgt gtaagggatt cctccaaaag atcaccaata tcctcatcat cctctacgac 2093641 taatattcga taggccatgt ctctctcacc tcatgattct tgttgttatt tctcgtgtgt 2093701 ccttactata tatcgttcat agtaataagt acgttataag atactacgta aatcttaaca 2093761 atttatgaaa gctgatgctc gccacaaatt tgtcacattt tctaaaaaaa atgatgactc 2093821 ttcataaatt gttaagattc ggtctttata tttatccatt gtaaggctca agtttttcag 2093881 atccgcacta cacattgccg tgataaatgg gaaaggagta ttgatatgat tgtacaaaaa 2093941 gaaggacgcg ggcaaccggt gagtctgcgg gaacgggttc attttctgga catcgtacga 2094001 ggatttgcct tgcttggcat tattattgtc aattattttc tgatcgtaga ttcagtaaag 2094061 ggattcgaaa tggcctccga tgacgtactg cataagctgg tttcctggtt tgccgaaggg 2094121 aaattcgtta cgttattctc cttcctgttc ggagtcgggt ttatgatctt tatggatcga 2094181 gccgcgcaga aggtagagag tcccaacaag ctgtttgccc gcaggttatc tatcctgttg 2094241 ggatttggca ttttgcacat cacatttgtt tgggtcggtg acatattggc cttttacgcc 2094301 gtaagtggct tcctgttact cgccttctat aaacgcacgg ccaaaacggt gcttagatgg 2094361 attatcgcac ttatcgtgtt tcaattcctg actcctgttt tcacaatgtt gtacaatgtc 2094421 atcaatactg cagggtcaaa aaacccgaat ttttcagagt ttactttgtt tagccacagc 2094481 agccttacct acatggaatc catcagcact cggtggacag atatggtcac gatggctgcc 2094541 ggctctttct ctatgatcta ttccatgttt ctcatgtttc tgctgggcgt gtactttgtt 2094601 aagatggaat ttttcaaaga catggaagcg aaaaagccta tatggaagcg tatctggatc 2094661 attagcacaa tcgcttttct aataacacaa agcagtatat tactagacat gtttaatctt 2094721 tctgagaata tgctgtggaa ggacatttcc tctgtcttgg gtcaaaatgg cggcttaacc 2094781 ggaagtatgt tttatatgag cacttttgca atgctgtttc tataccttcc tcagctgcga 2094841 ggccctatga tgatattcac caaagtcgga cggatgtcat tgacctgtta tctgcttcac 2094901 tctatcattg gaacagttct gttcctcagg tacggattcg ggcttgcgga tcatattcaa 2094961 tccgccggca cgttcatgtt cagtctggcc gtgtacttcg ttcttatgag ctttagtaca 2095021 ttgtggttga aacggtttag gtacggtccg atggaattag tatggcgcaa gctgacgtac 2095081 ggcaaagtaa acgggagtcc caaagcaact ccgctgcatt cggaaaaatc tattcagaaa 2095141 taaccccctt gcacagattg catgacttca aattagtgtt gttgaatgaa gcgggcatta 2095201 aacggacaga tttgatatat ggactagtta tttttatatc atttaggctt ctttgggcta 2095261 ataaatccac cagagtttac tcaatgtgca ttgctcatga tcgaatctaa attgaatctt 2095321 ttacgcatgt tcatagtcaa aggcgcctca ttcgactatt tttgtaactt ttcgcaggaa 2095381 aaattcgaga atgatgacaa atcccgcata cgacacttaa tacggtagtg aacaatagta 2095441 aattagggtt acatgcagct tgttttccaa tgaaacaaag aaaaagaatc atacaaaaag 2095501 acaggagaaa gcttttgaag tattttaacg ccaaatttac cgcggaagaa agagcgatgg 2095561 aatcactttt ttgtgaaaag gcctcgcaga gcagctcgaa tgttttactg aacgactgaa 2095621 ctctatattt tagcaactga gggagtgaac aatcatgaaa actaaaaatg aaccaaaagt 2095681 tattctggaa ctagcaaagg aatctgatct gccagaattc caaaaaaaat tacaagaagc 2095741 ctttgcgatc gccgtgattg aaacgttcgg tgattgcgaa gatgggccga ttccatcgga 2095801 caatgatgtt caggagtctt tcaatgctcc cggagcagtg gtatatcata ttcttcagga 2095861 tggtaagaat gtcggtggtg cagtagtacg tatcaacagc caaacaaatc ataattcgct 2095921 agatttattc tatgtatctc cagaatatca cagccaaggg attggtcttt ctgcttggaa 2095981 agccattgaa gcacagtatc cggatactgt gctttgggaa accgtgacac cttatttcga 2096041 aaagcgaaat atcaacttct atgtgaataa gtgtggattt catatcgtag agttctacaa 2096101 tgaacatcac tctaatccgc atatgcatcg caatggacgt gaagatgaca agcccctact 2096161 gaatgatgat gactttttca gatttgtaaa gattatgaaa aaaaaggact aaacaattga 2096221 acacggcgag atgccgcaga gagttgctgg taactttttt atatttcatt atcagaggaa 2096281 ggtaataatg atgtttaaaa ggtgttttga tccctgtctc ataaacaggg gtcaaaacac 2096341 ctttgaatca tcggtttctt ttctgacata taccacgccc actagtccct caacatagta 2096401 aaaacatatc atgagttaca aaagctttta ttcaaagcat atgtttattt tatttatact 2096461 tattttcatc atttttcaga attctggaca caaatcgggt acctattaga ggccaaggaa 2096521 ctctacattt cattaagaaa tacgtactca ttgccctgct ttaattaatt ttaagccctc 2096581 gcactatgcc cccccctgaa ttaagtattt gatgtaactt tgaaattaag tttatgaaaa 2096641 tctgtcacaa acccttattt cataacacat catttgtttc agcttccctc gcgaataccg 2096701 gattaatgct cggctttaag atagtcaacc aatctctccg cactgttctt aacatcttct 2096761 tttgaaagat gaagtgtccc atattgtgta aacgcaggaa gaaaacgcat tcctatatag 2096821 ttagcagtga cttgaaacgg tctgataagc tcgctgatcg tgatattata ttctccgcct 2096881 gcttgataat cagattcctg tgcgcctaag gagatagcta agagtagttc ttttccatgc 2096941 aatttagttc ctccagttcc ataagcccag ccatgtgtta acacatcatc ttcccattgt 2097001 ttgagtaacg cgggactgct gtaccaatac attgggaact gaaaaacgat acgctcatga 2097061 tctaacagga gctgctgctc tttttctaca tcaatgataa aattagggta ttcaccgtac 2097121 aggtcatgaa ccgtaatgtc tttctcttgc tttaaacgat tcatccaggt tttgttgaca 2097181 acagacgttt ccaaattagg atgtataacg ataactaatg ttttcattag actgattatc 2097241 ctttctttgc caattagtta ttatttttta cgataatgaa ttgattctaa ttttaaaata 2097301 gcaactttat ttacacctat tttatccttt ttcatgaatt cagggcaact aattgggcac 2097361 caaaatcaat gatgacttaa gacattgttt tgtagaaatc cgatatacag aataatccat 2097421 tatttagaaa atttctacct tttccctcaa tccgagctcg ctcttcatgc ggatggccta 2097481 ttttaaagga ataactgact atgttcatca gttattcctt taaaatacga aagtctacga 2097541 tatttccata tcgatccgct tcaatgtgac agcacccctc aagcagctgt tttaattttc 2097601 cacgtccgcg ttgtaccctt gattttgctc cggagtaaga aatgccgagc ttttcactca 2097661 actctttttg tgataacccc tggaaatcag ttaactcgag cgcctctcga tacttttcag 2097721 gcaaccgttt gatggtcgat cgaatacaca cagttgcttc cttggtgaaa ttttcttcct 2097781 ctgcactgtc attaaaatgt agaacatcag gcaatatttc gcttgttttt tttgtacggt 2097841 aaaaatcaat aatcgtattt ctagtgatcc gataaatcca gctgtcgatc ttttgttcat 2097901 cgatcagatt tgggagatgc acttgtattt tcataaatac gatttgcaag aggtcatcaa 2097961 cgatagattg atcgttaacc ctatgtgaaa tatatgtttt taacggctga tgaaattgat 2098021 cccatagatc ctctatattc atttgaaaaa acctcctata attttgcgtc tgctttacat 2098081 ttgcttcgtc tttttaatcg taacaaagag caaacaattg ttgaatcaat tgtattgcag 2098141 ctgttgccaa aaataatgat aaaggagagg tttgttgtgg agtataccta tttagggaga 2098201 acaggattgc gggtgagccg tttatgttta ggcacgatga attttggagt tgatacagac 2098261 gaaaagactg cgttccgtat catggatgaa gcacttgata acggcattca attttttgat 2098321 actgccaata tttacggctg gggcaaaaac gcaggattga cagagagcat cattggaaaa 2098381 tggtttgcac aaggaggaca gcgccgcgag aaagttgttc tggcgacaaa agtatatgaa 2098441 ccgatttctg atccgaatga cggaccaaat gatatgaggg gcttgtctct atacaaaatc 2098501 agacgtcatc tggaaggatc actgaagcgg cttcagacag atcatatcga attgtaccaa 2098561 atgcatcata tcgataggcg gacaccgtgg gatgagatat gggaagcttt tgagactcag 2098621 gttcgctccg gcaaagtaga ctatattgga tccagtaatt ttgcaggctg gcatttagtt 2098681 aaagcgcaag ctgaagctga aaaacggcga ttcatgggac tcgtcactga acagcataag 2098741 tatagtttat tagaacgaac agctgaaatg gaagtgctgc cggctgcacg ggatcttggt 2098801 ttaggagtag tggcgtggag tccccttgca ggagggcttc ttggcgggaa ggcattgaaa 2098861 agcaatgccg gaactcgtac agcaaaaaga gcagatttaa ttgaaaaaca tcgtttgcaa 2098921 ctcgagaaat tttcagattt atgcaaagaa ctaggagaaa aagaagcaaa tgtggctttg 2098981 gcatgggtgc tggcaaatcc agttttaact gcgccgatca tcggaccacg aacggttgag 2099041 cagctgcgtg atacgataaa agccgttgaa atcagtctgg ataaggagat tctccgcatg 2099101 ttaaatgata tctttcccgg acctggagga gagacacctg aggcatacgc ctggtgatac 2099161 attcattact caatactgac atttttctta aatatttata ctgaactatc atattaagaa 2099221 agacaagagc atgtttgtct cttgtctttt ccacatcgtg ctgaaaatgc tggctaaaca 2099281 tcgacaaaaa tgctgccgct taaaaaagaa ccctaaacaa tagagtaact ggaaagacaa 2099341 ctggcttgat cagcttggga cccctttcag ctgtatttaa atcaatcaaa ctaatgattc 2099401 attggcagtc taaatattat tattgtttct ttacaaaata gtaatagccc ctgtaatgat 2099461 tgctaacaac gtaataacta atgatgtaat tacagcccac ttaacggcaa acctttgaaa 2099521 tgaccccaag tccattttaa gcatgcttac tagcaatact gttgacgcaa ccaatggact 2099581 catcagatga accggctgcc ccattataga agcccttgca atttctactg gttctatacc 2099641 atatgctgag gcagcttctg caaagatagg taccatacca aagtaatatg catcatttga 2099701 taaaacaaaa gtaaacggaa tactagtgag tgctacaata acggggaaaa accctcccat 2099761 tgatgagggg atgatggata ttaatgatcc tgctatggca tccaccatct ttgtcccgga 2099821 taatatacca gcaaatactc ctgctgaaaa taccaataat accacggtta tggcattacc 2099881 agaatgctcg gcgattcgct ccttctgcat ttttacattc ggataattta tagtaagggc 2099941 aagaacaaaa ccaattaaaa ataaaactga cggatgctta gttccaagca caataaacac 2100001 catgatactt ataacgagga ataaattaag atatattaag cgtggccttt tcaattgttc 2100061 gctctccaaa gtagcagcca tataagattg agagctgtcc tttgttatat gtctaggctc 2100121 taattgaacg atgcctattc gattcctctc tttccttccc attagaaaag ccagaaatat 2100181 cacacaagca atacctccaa gcatggtcgg aagtaatggc acaaagaaat ctgaaggatc 2100241 caaacccagc actgaaatcg ctcttgtagc tggtccgccc catggagtca ttccgctaac 2100301 gatactcaac gacagcattg ctaatgtcgc cataaccatg ggattcatac caattctttt 2100361 atacaaaggt aacattgctg agactgttat catataggtt gttgtaccgt ccccatctaa 2100421 agcgataagc attgccaaga cggcagaccc tatcgctatt ttcacagggt ctccctttac 2100481 tatagataaa attttttcta ttagcggatc aaataaacct gcatcaatta aaattccgaa 2100541 aaaaagaata gcaaacaata gcaatgccgc tgaacttgca actgtttgaa ttccttctaa 2100601 aatcatgtcg ccaataccct taccaaaacc tccaataaga gcaaaaacaa tgggagtgat 2100661 ggtcaaggca acaataggcg agactttctt tgtcattatt aatattgtaa aaacagttac 2100721 catcgaaaaa cctaaaatag taagcatatt acacctccaa gaatgcgctt tcaaatgact 2100781 tttgattaac atatcttata cggtgtaata agttaaataa atattttttt actgtgtttc 2100841 aaaaaaaatt ctatcataac tttaaatggt taccatttgt tcacccttta aaaaatcaat 2100901 gaatgcttta acgagtttga ttcctaatga tttttgatcg tacattagcc aagtatctct 2100961 cattagaggc ttacccttag cattatacag ttccattgtg tacaaatgat cagattcctg 2101021 caggcaaatt tctggtgcta tggagtaacc aagaccatgc tttaccatct ctttgcaagt 2101081 ctcttgtcga tccacttcca ttgcaataat gggggcttgt tttagattcg tatgcatcca 2101141 atcttctata atcgttttta aagaagcatc cgttttatat ttgataaaag gtaaaaaagg 2101201 aagttgctct atcgttattg gtttttttga gatgatatgt aatttttccc gtgtcagccg 2101261 ttcctccacc cctttccagc gatggcttcc tctcagtata ccgacttgta caataccagc 2101321 atctaataat ttcatgacat ctgtgctcca gcctgtttgt acactatatt ggacattagg 2101381 atacatagtg gaaaattccc ttaataactt agggagctta tattgagcga aattgcttga 2101441 tacccccagc cttagatgtc cttgcacctc tttgcttaga ttagagatat gatctttggt 2101501 atcttgaagt tcctgtagca ttcttcttgc ataagcaacc aagtgttctc cttccgcagt 2101561 aaaggtaatt cctttatgcc ttttggtgaa taattcaatt ccgaaaatct cctcaatctt 2101621 tttcaaccga taagtgatgg aaggctgtga tgtaaataat cgttctgctg tttttgttac 2101681 actttgttct tcgtgaagaa ttttcaataa aatccaatct ttctcatcca ttttcatctt 2101741 cctttctagt ccttctttca caattataaa agttttttta tcgaatatta agaaaactta 2101801 tattttattt ttattttttt accttctaca ctaaaaaaca taaaaaatac tacctttaag 2101861 atgaggatga tgacgatggt caagacgaat gtaacaatca tgagaggcgg aacaagcaaa 2101921 ggcgtttttt tccacgaatc agccatgcct aacaataaaa acgaatggga gccctttttg 2101981 cttgatgtca tgggaagtcc tgataaaaga caaatagatg gtttgggtgg cggtaattcc 2102041 cttactagta aagtggcaat aataaagaaa gcatatactt cggatattga tgttcactat 2102101 actttcggtc aagtcagcat ttcggaagaa aaggtggact ttaaggggaa ctgcggaaat 2102161 atctccgctg ctgttggtcc atttgctatt gaagaaggac ttgtaaaagc gaaagaacca 2102221 atgactgcgg taaggatcct gaataccaat acgaataaaa tgatcattgc ggaagtagaa 2102281 gtggaagacg gtcaggtcaa atatgacgga gatgttacga tatctggagt acctggatct 2102341 ggatctccaa tctatttaaa ctttcatgat gccgctggtt cagttaccgg tcatttattg 2102401 cctactggaa atagttcgga gtttttagat acaagtcaag gccaaataga ggtgtctatt 2102461 atcgactatg caaatccatt agtttttgtg gaagcgagca gtatcggcct ggatggaacg 2102521 gaacttgcag aagaatttac tgatctacag ttggctcaat ttgaagaatt aagatccatt 2102581 gcggcagaga aatgcggctt tgccagtcga ttttcagcta caaagttatc gccggctgtc 2102641 cccaaactgg ctatagtagc aaaaccagag aaatataaag atagtacagg tgcttggcat 2102701 tcaagcgttg agatggactt acacatcagg atgatgtcca tgcaaaagcc acatcaagca 2102761 ctggctgtca ctggagcgat atgtacaaca agagcccttt cagtggaagg tgcaatccct 2102821 gcaagaatag caaaaaacca ctctacaaag gttcggctag ctcattcttc tggtattatt 2102881 gaaacaatgg tggagcccac tggtataaag atcgtccgta ccgcacgacg tattatggac 2102941 ggaacagttt atacgcatgg agactatcaa atgatgtaga tggactgtgc aaaaagcctc 2103001 ccccctttcc atcgttaata gatggattga atgcgccttc ttgcacagat ccattgtaat 2103061 cttgcatggc tttaaaaaag cctctatatt gttttttatg aaatcgccaa ggtcctttca 2103121 tgtatctgcc tcaagcatga cataatcatt atagagaaaa ttgaatactt tttactgcaa 2103181 ataaaaagat accaacatca ttggtatctt ttagattgag ttcatctgca gcggtttctt 2103241 ttcctcactg cttatttgat tacaaaatta ccgtactcgt ttgaacgaac atgaatcggt 2103301 ccgtttagat tatagttgtt ctccttggcg atagagcgaa gcacgtccac acgggcaact 2103361 gattctctcc attcgtcacg ggtgtcatga ttggccggat tcatcagatc gtcatagcgt 2103421 acgtccaaga atttattcaa ccacttcttc tcgtctattc cgtctttagg tgatccgccc 2103481 gcttttttgt tcgtacgttt aatcaaggca taaaaagagt cagggtcatc accatcgcca 2103541 tgctgaataa ccgtatcgta catcacagct cttgccaatg ctgtttttag tccggcatta 2103601 tccgatcgtt tcatggcagg ctgataatac aaatggtcat ttactttgtc ttgagcggcg 2103661 cgaaattcct tatcatttgc aagcgacttc caggcagaag cgaatccctt gagattgctt 2103721 gtatcatcgc tttcttcctt ggccagacgg cgcaattcag gcagatactt tttcagtttg 2103781 ttattcggaa ctgcctttgt gtatacttcc actacttcca atgcatcccc ggtagccgtt 2103841 gtaaagcctg cccgtccgca tgtatagcct cgcccgtcat ccaatcgctc tacatatcca 2103901 tattggatct ccgttgtgcc gttttcaaag atacttgtca gctgttccgc ccggcgcttt 2103961 tgatctttat tcagtcccgc cgcaaaaacc gtttcgctca tcatcagggt aaaaaacatg 2104021 gtgaaaacaa gtaatgagat cgctgctttt ttccaaaaat ctgctttttg catactgatt 2104081 ttcatttcac ttcccctttc taaatattgt aaatacagac tcagtataca tgaagaaact 2104141 gccctattgt tgaaaataca tcaatttgtc aatattttga atctaaagta atatagcttg 2104201 aatcttactc tattcattgc caatcagcct tagcccctct cactgggaag gtcccttgat 2104261 tttcatactg cttcaacttt cattaacaag atgccataag gctttactct attttataat 2104321 ggaagtgatc atcgaaaatc gttagggagg tgatgtaatg gcaagcaaga tgagaatgcc 2104381 agattccgca acgtcccatg caaagcctac tattgggaag gcgatacttt gcatggggta 2104441 gactttctaa aagatcgccc aagtaagctt ttctgatata gtggctttgc accttatttg 2104501 acataaaaaa ataaggagct ggcagaaatg gcatatgtaa aagcaaccgc tattttacct 2104561 gaaaagctga tatcggaaat tcaaaagtat gttcaaggaa aaacaatata tatccctaaa 2104621 cctgaatcct ctcatcaaaa atggggtgcg tgttcaggaa caagaaagct gatcgatgac 2104681 agaaacgctt ctattaaaaa agcatttaaa aacggcaaaa ccattcatca attatctgat 2104741 gaatatcacc tctctattga aacaataaaa aaaattgtct actctaaata aacaaaacgg 2104801 aagcactgat aaaaaataat cagtgctttt tatatggcga gtttgtttct tagttatttc 2104861 ctgcatatga taccattggc caattgtgta aagttaaggg agatgagaag aaaggaaggt 2104921 cctacaaatg acgataaaca atggaacgtt gcaagtaccc ggcgcgaaca tccactatca 2104981 ggtgcgtggc tctggtccaa tcattctttt ggtccacgga ggaggcggtg atgccgacaa 2105041 gttccatcat gttgccaatc atctggctaa ctggtacacg gttgttactt atgatcgccg 2105101 cggccattcc cgcagcaatc tcgccaatca gattgagggt taccgtgtgg aaacacacag 2105161 tgacgatgct caccgtcttc tagccaaaat caccaataag ccggcctatg tatttggaag 2105221 cagctccggg gctgttatcg ggcttgatct gtgcatacgc catcccgaac aagtacatgt 2105281 catgatccca cacgaaccaa tcttattgca gcttctgcat ggaaatgagc tgaaacaagc 2105341 cgagcaattc atggaagacc ttaagaaaaa tcatcgaagt gaagtcatta aattaatgtc 2105401 aagattagag acagacgaac aatcaaaggc tgtcctgaca aagcggcttc tcggcaattc 2105461 aacgtatttc actgagtatg aaattcaagg aattctcagc tatacattag atttcgaagc 2105521 attaaaaact gtgtttacat cttcaccgat gaagatactc ccagctggcg gaagtgcttc 2105581 tcgggagctt tttccttatc gttgcgcgaa cgccctagcg gaacaattgg aaacagaatg 2105641 ggttgaattc cccggaaatc atacggggta cacaatgtac cataaagaat tttctgagag 2105701 gttacacgac atgttagaaa aagaaaagaa acatacgtgt taaggattga ttaaaatttt 2105761 caaaatagga caggtgaaac taactatgga attggagaag atttcacgaa gcgtaaaaag 2105821 aacttttcac taacgagaac gcaatgtgag atgtttaacc aaagtgatat tagggatttc 2105881 atcgaaaaat aggtttgtac attacgttct cctattgatt atttcctatc ttaattccgt 2105941 attttatacc attagataca actctaaagc ggctcgttat tttgtcctca acaacaacca 2106001 gtgtctaaca tcatgaatct cttttgaaaa tcaccacaaa tgcaggtatg gaagacttca 2106061 tcgcagcaaa aaccatacca actattgttg ttggtatggt tcgtcctaga taggccctta 2106121 agaagagatt ctattgtacg gagtatttag ctaattgcat ttgtaaccga cagggccgtc 2106181 tgaacctgtg tacacatatg tgtcagacac atatccaata ttcacgacac cccgggaatc 2106241 tttccactgg atttggtccc agatattact cgttccatac ttccctgtaa cagtcgttcc 2106301 ataagcgtaa caataataag gaacacggga gccactcgga atggaaagca taataggata 2106361 atttgtacca ggaccgctgc gcatattgac aggcgcaccg ctgcttgttg agacagtaaa 2106421 gtactgaacg gcaagtgcct gactggaaaa aatgaataaa gatgcaatca tcacggttaa 2106481 catactcagc attttcagtt tagtcaatgt catccctctt tcttcaattc cttcatttta 2106541 agaaacgata gaacataggc taccagctgc atttaggaac aaccggaccg tctgagcctg 2106601 tatacatata tgtatcagag acaaatccag gaacgatctc cccgctggca agcgtccgct 2106661 ctgtgtaatt ccaaatattg ctcgttccat actttccagt tacagttgta ccggttttgt 2106721 agcaatagat cgggatgcgg gttccgctcg gaatggtcgt tacaattccc caacttgtac 2106781 ctgggccgct gcgcatgttg acaggagcac cgctgcttgt tgaaaccgta taatactgag 2106841 ccgcaagtgc atggctagaa aaaatgaaca cagatgcaat catcaccgtt agcatactta 2106901 gcctctttaa cttattcacc ttataccctc cccttataaa tgccgtacgt ttgactttct 2106961 tacatccagt taaggattta ctttcagata ccatgccccc tcccctccca tatatttatc 2107021 aatgtaccat aaactagatc tttcaaaagt ggaattattc ctatgttttc gacaattaag 2107081 gatacaaaat aaatggtagt caggcttgat attgatggtg tgttacattt ggctcttaat 2107141 catttgtcca gtcggtaatc acgattgaca atcaggaaaa aggacatgga tcaagcggct 2107201 tcgtttccac caattaactc aatcagtgta ctgcttcctt gtatccacgc ttcttctcga 2107261 ttcatagata ctccaccttt ttcaccaatc aaaaacggac accatacaaa tcagcgtaaa 2107321 tgctgcaagt tcagtgtccg caacctatta tgactttgct ttcttttacc agggcgtgta 2107381 aaaatgatta ggtacgttat caaacgttat tctatgattt tgcgagtcaa aaaatcataa 2107441 cattttatat atttcaatca gattatgatc tggatctctg aagtgagcaa ctcgggcact 2107501 ccattccttg cgatcatgcg gtttattctc acatttaact cctttttcgt gtaaatcgtc 2107561 atacgtttta tcaacatctt ctaccttaaa ctgaagcaaa aattttgatt gagcttctcc 2107621 ttccaaggac tttttttcct ctccaacgat ttcagccatc gtttctcgag ataaaagctc 2107681 tattttcgtt tccccattat caaagagtgc atattccatt tcattctcta accaacttat 2107741 tggaagtcct aatgaatctt tataaaactc gacgcttttc ttaaaatcat tcaccaacag 2107801 tctaatttgt aacagcttca tatcgagtgc ctcctataaa accatacttt tactggtcat 2107861 ccaatttaat gataccaaag aaacctgaca gcactatgtc aagtttccat acttcaccct 2107921 tatttcagat ttaagtgcag tttagtccat gtcataagaa cgagcaaaaa cagcgattct 2107981 taaaacaaaa aatgataccg agtgtatttt ctgtatgctt caacttcatt tcgggaaatg 2108041 taacgttgat aaaaggaggt tacatcaata tggatcatca aacattggca gctcatgagg 2108101 ctgttgactt acatgaaatc gtgaacttta aaacactttg tatagcgaaa tcaaagttaa 2108161 tgcaagggct tgtgtttgac caagaactga aggacttgat ggaaaaagat gtacagcaat 2108221 ccattcaaga ccttactgaa ttacaagcgg tttatgagcg tgcctcattt caggcccctg 2108281 tccctcaaag ccgcccaacg ccaatcatca attgaaaggg aggtaagcct ctttgaataa 2108341 tgatcattta gaccccatta attcgctgaa tgtgcctgaa ctagcagaca ctacattcgc 2108401 gatggatttt cttatacgag ctaaggaagg cgtaaggaat actgctgtag ctttgacaga 2108461 aaccgcttca ccagatgtaa gagcactgct tcggaaacag ctgatgcaag gaattgcgat 2108521 gcaccaagag attacggaac tgatgatcag caaaaagtgg ttccatccat atgagctgag 2108581 cgaacagtat aagctggatc agctctctgc aaaaaacacg atcatggtcg gcaatatgaa 2108641 cctctttcct gatgaaacaa atcgcaaagg gatgtttgac cggacacctg atgaacacta 2108701 acactggagg ttttacagca tgaaggcagt aacgtatcaa ggcattaaaa atgttgttgt 2108761 caaagatgtc cccgatccaa agattgaaaa atccgatgac atgattatca aagtcaccag 2108821 tacagccatt tgcggatcag atttacattt aatccatgga ttcattccga atatgcaaga 2108881 agactatgtc atcggccatg aaccgatggg aatcgtcgaa gaagttggtt ctggggtgac 2108941 taaactaaaa aagggagatc gggtaattat tccctttaat atagcatgcg gggaatgctt 2109001 tttttgtaaa aaccagctgg aaagccaatg tgatcagtct aatgacaatg gggaaatggg 2109061 tgcttatttc ggctattcag ggcaaactgg cggttatcca ggcgggcaag ctgaatattt 2109121 aagagtgccg tttgcgaatt ttacccattt taaaatccct gaatcttgtg aggaacccga 2109181 tgagaaatta agcgtgattg ccgatgccat gaccaccggc ttttggagtg tggataatgc 2109241 cggcgtaaaa aaaggcgata cagttatcgt tctcggctgc ggaccagtcg gcctgtttgc 2109301 tcaaaagttt tgttggctaa aaggcgcaaa acgcgtcata gcagttgact atgtaaacta 2109361 tcgcttacag catgcgaaac gtacaaacaa agtagaaatc gttaattttg aagaccatga 2109421 gaatacaggg aattatttaa aggaaatcac gaaaggcgga gcggatgtag tcattgacgc 2109481 tgttgggatg gatggtaaaa tgagcgatct cgagttcctt gccagcggct taaagcttca 2109541 tggcggaacg atgagtgcat tggtcattgc ttcccaagct gttcgcaaag gaggaaccat 2109601 acaaattaca ggtgtgtatg gaggcagata taacggtttt ccgttaggag atattatgca 2109661 gcgaaacgtc aatatacgct ctggacaggc tccagtgatc cactatatgc cgtacatgtt 2109721 tgaactagta tcgacaggca aaattgatcc gggagatgtt gtcagccatg tcctgccgct 2109781 tagtgaagcc aagcatggct atgacatttt tgattcaaaa atggatgatt gtatcaaagt 2109841 tgtgttaaag ccttaaaaaa cggaggttac agaaatggaa tacgccttac acgaagtgct 2109901 tgaggttcag gaaatgactg catttaagac actttgtttg acgaaatcta aaacaatgaa 2109961 agcactggta tctgatccga agctgaaaga aatcatgcag caagatgttg atatcaccac 2110021 acgccagttg caggaatttg cctctatttt atctaatgca aagcaagaat gaggagatga 2110081 ataaatcatg aatcctatca tagaatatct gactggcatg aatgttctaa cagaccaaat 2110141 cattgctatg gacttattaa tttcagcaaa gaacggagtc agaaattatg cgatggcagc 2110201 cactgaagcc ggaacgcctg aagtaaaaga ggtccttatc cgccatttgg aagaagcact 2110261 cgatatgcac gaacaactct caagctatat gatggaaaaa ggctggtacc atccttggaa 2110321 ccctgacgaa caagtcaagc tgaatttaaa aaatattgat acagccattc aattgccaac 2110381 cctttaacat acaatgactg atttgctgag gaacagtatt gattggccac aactgttcct 2110441 cagcttcaaa atgagcactg tttgttcggg tcctatgacc gtaaatagat taaccgcttt 2110501 tctccatctg atctccgata atgtttgcaa attctccaat ccaaataagg aatcgtaacc 2110561 acctcttttt atgcgatctc ttgatggaga aaacaggcca gaaacaaaat ccttcgtttt 2110621 tgacctgccc tcttcacacg caaagaatgc taccttcttt gctccactga tccgtgaaga 2110681 ctttccgttt taggcctgct tttgagcttt gcctcatttt cacgcaattt cccatcataa 2110741 tctttaattt ttgtgtctaa tctcttaatt gtttcatcaa tttctttccg cttctctatc 2110801 agccgctgtc gttcgtcagc caggatattt tttcgagctt ctaccgtacg gtcaccttcg 2110861 gtaaataatg ttgtatattc aattagcgct tctatcgata gtcccgcatt tcgcatgcat 2110921 ttaatgaatt caatccattt gatatcttct tcatcatagt cgcgaatgcc gctgtctttt 2110981 cgttttacag gcgggattaa tcctacacgt tcgtaatatc ggagtgttgc ggctgtcagg 2111041 ccaaactgct ttgccacctg agcaatattc atgatcttca cctctctatc ctgtatgttg 2111101 tgaaggtaac acttaaagtt aactttaagt caagctcaaa acaagtggtt agctgctgaa 2111161 tctgggttta tatattcggg acttgcctta aagcacactt taaactctat acttctccat 2111221 gcactaaaaa cagtgtagtt ggagggattg ctgaatggca aataaacaca ctgccggaag 2111281 agaacaatta ggagaatttg cgccaaagtt tgctgaactt catgatgatg ttctattcgg 2111341 tgacatttgg gcaagagaag aagaactttc atcccgggat cgcagcatga ttacagtttc 2111401 tgcattaatt actgactgtt tctcagctta taaatcaggt tcattttaaa tggttttttt 2111461 aaaaaaccct tgccttaaag cagactttaa ggtttatcgt tatgttgaag acaccataaa 2111521 acataaataa gtgcatgttt ttatttacaa cacttatgat gaagaaagga taggttcgta 2111581 tgtgtaatca acatcaaacc cgtgtattaa gcgtgtcaca tgcaaaagcc aaatttgaac 2111641 aaacgacgat tgagcgaaga ggattacggc cgcacgatgt cttaatcgat attaaattca 2111701 gcggcatttg ccattcagac attcatagcg cttttgatga atggggcggt ggcatcttcc 2111761 caatggtgcc tggacatgaa atagccggtg ttgtaacagc cgttggaaca aaagtcacca 2111821 agttggctgt cggggaccgc gttggtgtcg gctgttttgt tgactcttgc ggagaatgcg 2111881 aatactgtct caacgcagag gaacaattct gcacgaaggg tgttgttcaa acgtataact 2111941 cagtagacta cgacggaaac cccacttatg gcgggtacag ccaaaaaatc gttgtcactg 2112001 acagatttgt tgttcgcata ccagatcgtt tggaaatgga tgttgccagt ccgctgttgt 2112061 gtgcaggtat cacaacgtat tccccgctga aacactggaa tgttggccct ggtaaaaagg 2112121 ttgcgattgt aggcgtaggt ggccttggac atttggcaat tcaatttgca catgcgatgg 2112181 gtgcagaagt aaccgtcctg agccgttcca tgaataagaa agaggaagct ctggaactcg 2112241 gtgcaaatca ttactttgca acaagtgacc cagccacatt cactgcattg gccgggcgtt 2112301 ttgacgtgat cttaaatacg gtatcggcaa atctcgatgt agatgcctat ttatcaatgc 2112361 ttcgtataga cgggacactt gtaagcgttg gagctcctgc caagccggac acatacagtg 2112421 tgttttccct aatcatgggg cgccgcagca ttgcaggttc tctagtcggc ggaattcaag 2112481 aaactcaaga gatgctggat ttcgcagctg agcatggcat cgaacctaaa atcgaagtca 2112541 tcggagctga ccaagtggac gaggcatacg aacgtatcct ccgaagcgat gtccgttatc 2112601 gatttgtgat tgatatttcc acattgtaat aggttagtcc ttatatgggc tgccgctttt 2112661 attgaaactc acgaaaaatg atctctttaa gcaaatattt tgaaggccgg tcaatcttcc 2112721 tgttattcta tgaatagaga gttattagga gggtttttta tgagcaaaaa aattgcagtt 2112781 cttgttacag accaattcga agacatcgaa tatacaagtc cggtaaaagc atacgaagaa 2112841 gctggctaca gtgttgtggc tatcgatttg gaagccggca aagaagttac cggtaagcat 2112901 ggcgagaaag taaagattga caaagccatc tctgatgtgg atgcaagtga ctttgatgca 2112961 cttttaattc ctgggggatt ctctccggat ttgcttcgtg cagatgaccg tccgggtgaa 2113021 ttcgcaaaag catttgtcga aaacaaaaaa cctgttttcg caatttgcca cggcccgcaa 2113081 gtactgattg atacggatct tctaaaaggc aaagatatca caggctaccg cagcatccgc 2113141 aaagatttaa tcaatgccgg tgcaaactac aaagatgcag aagtagtcgt cagccacaac 2113201 attgtcacaa gcagaacacc tgatgatttg gaagcattta accgcgaatc tttaaacttg 2113261 ttaaaataac aagaaggcac agactgttcg ggtctgtgcc ttttttaaaa ttaagactcc 2113321 ttcgttacat tctgaaagac agcagtcgcg tcccacacat tcaagccaaa ttggccttct 2113381 gaaaatacgg aatcatgtgc atcaatcaca agacgatcat ctaaatagat tttaaagcga 2113441 tcgccctcgg cctctgtttt cagatgatac tttttattaa cgtctatcgg tgttttgtat 2113501 tcagcaatga cagaagcagc accgttctca aatttaaaga atttcactag gtcatgcttc 2113561 gcatccacat tggcaaggta accgtttttg gcatctttgt cagagcgaaa cattagtgct 2113621 cctgcccctc ttccgtttcc atccttaatg gtgatatcag attcataagt gaagtctgac 2113681 ccggatgctg aagacaagat aaaggaatcg ccgtccgacc tcccttgttt cccctcaatt 2113741 gtgtctgccc acgtgccatt tacagtcgtc cagccagtca tattggacat aaaaggtgtc 2113801 gttccccata ccttttttaa agggtgtatc gttaaagatt ttacctttac accgccattt 2113861 gcagcatata attcaagccc tttgcttgat cggtctggga gaataatatc cgttatgacc 2113921 tgctttccgt cattcccaaa tacttcaacc gaggagcggt caacaaaaat gcgcaactta 2113981 accttcccat ttaccggctt caacggggct gtttcttttc cggtgttaaa ggccggatta 2114041 aaggtgtcgt tgcctgactc gctccggtca acgaacaatt tggcgttcct tcggtcatag 2114101 ccgaccttcg taaattgatt ttcacctgtt cggaccttaa aaccaaattc agcagctgaa 2114161 ccagggctta ctttaaattc tgcatttatt tcataggcat ctccagattg ccccgctaac 2114221 acattatgac ttgcaggcga tatggtcaga ttcttccact tcttagaggt tccgcgaatg 2114281 gtttccagct ctttcaccgg tgtttggacc actctaaccc cttcggtaaa cgctttcaat 2114341 tttaactctc ttggaatgga cgttgcactt ctccatgggg atgtcggaac atcattcgca 2114401 tattgccaat tgctcatcca ccctaaccat agccggcggc tgtctgtgga tggaatatca 2114461 gaccaggata cagccgcata aaagtctctg ccgtaatccg tccagagaac tttgtttggc 2114521 gggttttcat ttttaaaatg agttccatca aagtccccta caaaatattg catgcctgat 2114581 cctcccgaga ccgctccgtt tccgacactg acctgcatga cccatttctt ttgattcgga 2114641 ttgccgtcta ccggaagctc aaataaatcc gggcattccc atactccccc gtggcttcct 2114701 tgatcctgtc caaattcact tgcatacgtc cactgcttca gattttttga tgtataaatg 2114761 aggattcggt caccggccgc aagcaccatc acccactttt tttctttctc ataccaaaag 2114821 acttttggat cgcgaaaatc ttttttaccc gggtttggaa tgacagggtt gccagcgtac 2114881 ttcgtccatg ttcttccttt gtcgttgcta taggcaatac tttgcacttg atggccttcc 2114941 cgatcctgtg tataaatggc cacaagcggc ttctctttgc ctgtttgaaa accgcttgtg 2115001 ttatttttat ctacaactgc gcttccagaa aagatcgtgc ctttttcatc cggatacagc 2115061 gcaacaggaa ggtgttccca tgtaaccaaa tctttgctga cggcatgccc ccaatgcatg 2115121 ggcccccact gaagcccgta tggatggtat tgatagaaca agtgatattc cccagcataa 2115181 tataccattc cgtttgggtc attcatccag tttgcctccg gtgtgaagtg atattgagga 2115241 cggtaatcct catcatagta gcttgaatcg gctgcatctg ccgaaaatgc catagtcaac 2115301 agcagggtga acatgatcat gacttgaatc agtctctttt tcatttgttc cttcgctcct 2115361 ctcttcatgt ttgaacactt tcaaaagaga ctgctgcgca agctggtccg tttctggcaa 2115421 ttctcctctg tttcactgtt atccgaatga tttatatatg aaaagactgc tgcagtttct 2115481 ctctctttcc ttcacacacc ttatgctaag aatccagccc aatacccgag aatcccgatg 2115541 acaaagatgc cgcaaataat gagaagtgga ttcacccctt tgcgaagcat ccatgccacc 2115601 aataacgtta atccgagagg cagcgccccc ggcataatgc tatctagcac gttttgtacc 2115661 gtttgaacat ctacttttcc gctttcatcc ttaatcctgg atacaacgat tggaatgttg 2115721 atggtggtcc atttggacac gagagccccc ataacaaata acccgagaat cgaagcgccc 2115781 tctgtaagct tttgaatgcg attccccgct aaatcctgaa gaatctccat tcctttcaca 2115841 tagccatact ttaatccgta atattttgtg cttaatctta tggcattcag caagaaaaag 2115901 aatagcaaag gaccggcaat gtttcctcct aaagcaaggg aggctcctag cgcagctaag 2115961 acaggacgaa tcgttcccca aaaaattgga tcgcctacgc ccgctattgg tcccatcaaa 2116021 ccgattttca ttccgcttat cgcttttccg tcaattcctt tattgttcgc catttcttct 2116081 tccatggctg ccgtcacgcc aaatataggc gctgtcagcc acggatgtgt attaaaccat 2116141 tccaaatgcc gctgtaaggc ttcgtttctt ttcgctccgg gaccgtacaa ttttttgatc 2116201 gccggtatca tgacataaca atatcccatt gcctgcacac gttcgaagtt aaaggaaccg 2116261 agtaaaaaat ttgaacgaat aaacatgctg aaaatttctt tcttcgttaa tcgtttttct 2116321 ttctccattt tttcttcccc ctcatcgttt aggcatcaag atcatcatca tcgtcatcat 2116381 aaacagcaac actgccactg tctgatgcgg ccgcgactgc tccgtgagcg ctttgttttt 2116441 gcatcacctg ctggtataaa agcgccagac agagaccaag ggctccaaat cccactaagt 2116501 taaaatcggt aaacgccgct aataagaaac caatatagaa aaatggcttt aaataaggaa 2116561 tattcatcat attgatcacc atggcatacc cgacaaccac aataatgcct ccgcctattt 2116621 gcagtccttt tgtaatgaca tcaggaatat ttcccaggaa cgcctgaaca gcgctgacac 2116681 taattaaagc aacaatcaat gtaggaatca tgacgcgcaa agcttgaaac accatcgcgg 2116741 taatatgcat aatttcaatt ccttttatat ttcccgcttt tgcatattga tcagcgcggt 2116801 ggatgaaaaa gacagtgatc gtccgaacaa aaatcgtcag cgcctgaccc gcagctgcta 2116861 aagcaacagc gacagcaatc ccttcgccaa ttccttgatc agcggtaata actaaaatgg 2116921 ttgagatgac agaggcgatc gctgtatcag gtgccatggc aagcccgacg ttcatccagc 2116981 cgagcgccat cagctccagt gtgcctccaa gaataattcc cgtttttaag tccccgagca 2117041 ccaagccaac caacgtacag gccactagcg gccggtgtgt ctgcccttca tccaatacac 2117101 ttgcgattcc ggtgattgct gcaatgatta acaacaaaat aatttgtaat gaagacatat 2117161 tctcatcccc ttgattattt tgttacgttc cgtaaaatct gtacaaaatc ctcactggca 2117221 tctgaaggca gctgcctcaa ttccagtttc acgcccttgt cacttaatgt ttcaaatgcc 2117281 tttatatctt gttctgtgac actgactgat tttgtgattt gcctgcgatg attttcaaaa 2117341 cgcattcccc cgacgtttac ggttttgatc ggtacacctg cttctataag agatacaata 2117401 tcggacggat tttcaaacaa gagcattgcc gttacccctt cgtagcgcgg actatgaaat 2117461 gcttttgcca ttttagaaac cgagacggca ctcgccttta catttgaagg cgcaacagaa 2117521 aggatcagcg tttttctcat ttcgtcctga gcaatatcgt cggagacaac gatgattcgg 2117581 tcggctgcat ggacttttat ccaccttgtc aggatttggc cgtgaataaa gcggtcatca 2117641 attcttgcta acacaatgtt catcataatt catcctctct tgtatcttga ttggctgttt 2117701 ttactttttc taaatgttca ctgcacactt gaaagctttg ctgactcatt gcttttaagt 2117761 tgttcagcaa atctttgaga gccagatgtt ctctcaggct taatacctcc agcagaatcg 2117821 gcaggtttac gccggcagcc atatccattc tttgatcctc agcaataaag gaagctgccg 2117881 cgttatatgg cgtccctcca aaaatatcga ctaaaaaaag cacttcatgt tcttccggga 2117941 tatccttgag cgcctgatga tatttttctt gcagcgtttg tattccttcc cctttgaaaa 2118001 acggcactgc aatcaggtta ttttcttcac cgaatatcat ccctgaagac tcttttaatg 2118061 ctatgggaaa atctccatga ccgctgataa taactgaaat catatctatt gctcctttcc 2118121 tgttttgtac atccatatat aatgcaagga tcgtgccaac acagttgtgt taagcgtttt 2118181 cattgttatt tcagccaata gcaatttgtt gttgaaacac ttaaaacgaa aaaaataaac 2118241 ctgtattaaa atggtgttcc atttaataca ggttcatatg aaaaaactgt ttttaaaaca 2118301 gctggccatg cacttcttca gcaaatatgg cggctataaa taatttttca tcatcactta 2118361 tgcgaagtcc gagcttttct tcataagggg ctaatgttcg ctctgtcacg tacaccattt 2118421 ccttcagctg atcattgatc tcttcttcct ctgagaaagc gatcggattc tgcttaatta 2118481 ccctttcaaa ggcgaaagcc gtgtgcataa tgactttgat caaaaccgca ttattgaaaa 2118541 tgacccccag ctcatcctga acggtttgca gccactccaa taacatgtcg atcacatggt 2118601 ggggattcaa gaagacaagg tattttttca ggctatcctc gcaaagctcc ctgacaataa 2118661 tatttgcttc gttcaatcca ttgctcaagg agatgcttcc ttttgtaatc gcctgttgaa 2118721 tcagcttctc tccctcccct tcaattaaca cttctaaaga tacatgcgga gcattgattt 2118781 tagggtcttt cgttccgact gtcgcaagga tttcatactc tttttcgatt tcttttatgc 2118841 tgttggccag cttaatcgat gatacggtca atatgtgaat gggggtatcg gaggccttgt 2118901 ttacgatcgt ggttagaatg tcttccagct ttttggccgt tccgctaccc gtcgtgcaga 2118961 tggataccaa tgccttcttt ttgccggatg ccgctggctg acgctcccac aactcgataa 2119021 aatccttcgt gaccgattga tagatcgcat gcaaatttaa attcaaatag ttgacctttc 2119081 tgacagcatc cagcaccatt gaagtcgtaa cattgctgat cgttttaata gaaatgcctg 2119141 tcttttcctc cagcctgctt tccagcattg caagcgaccc catatctacc agcattaaaa 2119201 caccttcacc ttcatcaacc tgtttcattt tttctgctac gcattcaaga atgtccgaag 2119261 gtgaaacagt aagcggcatg tcaactgctg caatcggcgt actccctagc agttctgtcg 2119321 cgacttcaac cattgaactc gccgtgctgt ttccatgagc tgccacgata ataccgactc 2119381 ttttgttctc ctttaacgat ttgatggaat gaattaacat cgttaagtag atgacttcta 2119441 tttcaggaat agccacttta aaatattcct gaattttatc tttaaaaatc atcgccaccc 2119501 gatattcttt cacatgggta tcacgaattt catctgtctc ctgtgtattc aaaacatcaa 2119561 tttgctttcc tcgctttaaa aatgcgtcaa tatgcatact caagaaataa ataaacttac 2119621 ggtcaaatgt gcaatccagc tcatgttcag ctatttcttt taactgtttt gtcatttgaa 2119681 tcacatcgtc ttcaacgaat gtcagcaggt tgtctttttg aaaagcttga tgatgaaaaa 2119741 aacttctgac atgcaaatgg acatcagtca agatgtactg gttaatatcc tttttggata 2119801 aaccttcttt cataagcgtt ttcacttttt cctcaatcaa atgatataag ttaaatgaga 2119861 ggtcttcgtc aatttttgtt gtttcatctt ctacaatcgg agagataatc gttgtaatat 2119921 tgacatattc agaaatggct ttgcttcttt gcatgttttt gctgctggac atccattctt 2119981 gcttgatttc atcaggcaga tcgcgaacag tcagttcaat aacttcattt ctgtcaaggt 2120041 tatgcaaaaa tccgtgtgcg caaactaact gaacatttga tttcagctgt ccgacattcc 2120101 caaatttcgc agagtgaata agcgcattat agacatcgat atgcacactc agattcttct 2120161 taattcgctc tgcttctttc cctaataaaa acgtcgtcag atccactctt tcattaagcg 2120221 atcgttcttc aagcgaagga atatgaatgg tcattgggat tcttcgcaaa aacgttttca 2120281 atagtgcaga actcggattt tctgtagtcg cacaaataaa caatacgttc gatgttcgtt 2120341 tatgttcaga ttctccaagc ctgttataag aaccgctgtc aataaaataa aacagcattt 2120401 cttgtccctc gggagggaga cggtggattt catccataaa aagaatgccc ccattggcct 2120461 gttcgactaa acccgcctta tcctcggcag cacctgtaaa tgaacctttt ttgtgtccga 2120521 ataattgaga aagcaataat tgagggttgt tgtagtagtc tgcacagtta aatgtaataa 2120581 atggtgcgcc ggccttcaat atgtcagagt aaatggcaaa ctggtaaatt cggttcgcaa 2120641 aaagggattt accggaacca gtcggcccta ggaggagcat atgcagaccg ttcggcggat 2120701 aaaagacagc tgcttttgcc tgggagatcg ctttcttcaa actccctttt gcccctatca 2120761 taagctctag gggattcgtg gaaatgtgtt gatgattttg ctttgaattt ccggaaaacg 2120821 cctgaaggtc tttcacttcc atcatctctg tatcccattt cttgttgaat aatttttctg 2120881 ctatctcgac tgggatgtat cttacaggaa atgttttaat tttgatgacc tttttggacc 2120941 ggacgagatt gttcaattca aagctgacat tggaccgctc cattttcagc tgctcggcaa 2121001 tctcctttgc tgaattccct tgtattttta aaagatgatc taaggttgaa tcatgaaaat 2121061 tatgcttgag ctgatggtat attttatcta ttcttctcac gtctatcatc ctttgtcctt 2121121 attagataag ccattaacaa gaatatttcg aaactttata gtccgcgttg agatttacac 2121181 gtttaaaaag gtctctatag cagattgaca aagctggctt ttatgcgtat atgtttacat 2121241 gttgaatcat ttgcacctca tattagtatg atagatgctc agttctggag ggccagtccc 2121301 cttcaaaagt aataatcagt aaacagttta tcattctcgg ggaatgtaat gatgtcaaaa 2121361 taatcaatga caaaaaatga atcttataga tcatgacaaa ttacccaaat ataacccctt 2121421 aagttcgttc acaactaaaa agacggacac tctatgtgac cgccacagta ttacaatttg 2121481 caaaacttcg tcatttttgc aatccacatt ggaggttaag gaatctgtaa gcttaaaaac 2121541 tttatctccg atcctatcga tttgatcccc ctgccggcct caatcatagt gggtatgcaa 2121601 ttatacaaat cgttaccgat taaaactagc ctgtcagatt gtccaaatga ctttcctgtt 2121661 ttactctgct attcaggtag aatcacgagt gaaaaataga gccacaagac atgtaacagc 2121721 acttaaaata gttttaaaat ttaaaaataa aagtatctat tcttttaaat gttataatat 2121781 ccgataaaac tttactcatc tttttattac tggaggaaaa taaaattgat aggcaattct 2121841 agcaaagaca attttggcca gcaacagaaa ttgtctagag gccttaaaaa caggcatata 2121901 caattaatgg cgattggagg tgcaatcggt acaggtttat ttttaggttc aggtaaatcc 2121961 atccattttg caggaccatc cattttattt gcttacttga tcaccggcgt attttgcttt 2122021 ttcattatgc gttcgctcgg agaactgctc ttatcaaatg cgggatacca ctcttttgtt 2122081 gattttgtaa gggactattt aggaaacatg gcagcattta tcactgggtg gacctactgg 2122141 ttctgttgga tttccctcgc gatggctgat ttaacggcgg tcggcattta tacgcaatat 2122201 tggcttcccg atgtgcctca atggctgccg ggtcttcttg cgcttattat cctgctgatc 2122261 atgaaccttg ccaccgttaa acttttcgga gaattagaat tttggtttgc attgatcaaa 2122321 gtcattgcca tactggctct gatcgtaact ggtattctcc tgattgcgaa aggtttttcc 2122381 gcagcttccg gccctgccag cctcaacaac ctttggagcc acggcggcat gttcccaaat 2122441 ggatggcatg ggtttatcct atctttccaa atggtcgtct tcgctttcgt gggtattgaa 2122501 cttgttggac tgacagcagg tgaaacagaa aatccccaaa aagtgatccc taaagccatc 2122561 aatcaaattc ctgtccggat tttacttttt tatgttggcg cacttttcgt gattatgtgt 2122621 atctatcctt ggaatgtgtt gaatccaaac gaaagcccat ttgttcaggt cttctctgca 2122681 gtaggcatcg ttgtggctgc cagtttgatc aattttgttg tattaacatc agccgcatca 2122741 gctgcaaata gcgctttatt cagcacaagc cgaatggtct attcacttgc aaaggatcat 2122801 cacgcacctg gactattaaa gaaattaact tcttctaacg tgccaagcaa tgcgctgttc 2122861 ttttcatcca tcgccattct gattggcgtt agtctgaatt atttaatgcc cgagcaagtc 2122921 ttcacgctga ttacaagtgt ttcaacaata tgcttcattt ttatttgggg catcacggtg 2122981 atttgccatt tgaaatatcg aaaaacaagg cagcatgaag cgaaagcaaa caaatttaaa 2123041 atgccttttt acccattatc caactattta acacttgcat ttctcgcgtt cattcttgtc 2123101 atattggcac tggcgaatga tacacgtatt gctttgtttg tcaccccggt ctggtttgtt 2123161 ttattgatta ttttgtataa ggtgcaaacc cgcagaggac ataaggtgaa ataaaaaaaa 2123221 gacaagggat actcactccc ttgtcttttt atatgtgtca aacactaaat taaactttgg 2123281 tttcaaattt cattcacttc atttaagtgt taactcaaac cagttttgat gccgaaacct 2123341 actaatatta ttccggtaat tttttgaaac actttctgga acttcgagtt tttcatccat 2123401 ttttttgcgt aatcaataat ataaacaaga aacaggaacc acaacaccgc taataaggtt 2123461 aggattgaag ctaaaatgat gagctgctgg tttatatttc cgttcaaatt gataaattgg 2123521 ggcatgattg taacatacac caaaacagtt ttaggattga gaatgttact gagtgatccc 2123581 tgcataaagg aagttttata ataacgtttc ggagaacttg ccatattttt tgcttgggat 2123641 tgcatgtcat ctaacgaaaa catactttta gcaaaaaaac tttttacacc taaataaatt 2123701 aagtatgccg ctcccaaata tttgatcgtt gtgaaaagaa tcactgactt tgcgattacc 2123761 actgataatc ctaaaatggc aatcaccgtc caaaaggaaa gtcctgtcgc caatccgaga 2123821 atgttataac ggccggcttt cggaccatac ctaagcgtat ttttcatcac aagcatcgta 2123881 tctgcccccg gtatgataac catcatggca gcgatcggta tgtatgcgag taagctgtgc 2123941 attgttctct ccccctttaa aaatcccctc aatcatatag tgactacaaa agtaactact 2124001 tataaaagtg tatcaatgcg tttggaataa atcaatatga tttgttaaaa tagcgattac 2124061 taaggcagcg attgctcttt atattggagg atatatgaaa gaaaatatgt tagacatttt 2124121 aaaaaacctc aattttacag aatatgaatc gaaagcgtat ttagcattat tgcaagaatc 2124181 acctttaaca ggctatgccg ttgccaaaaa atccggagtg ccccgttcta aaatttatga 2124241 agtattggaa agtcttgtca taaggggaga tgtttttgtc agtcatggaa atacgcctca 2124301 gtatgttcca gtccccgcaa aagaactgat taaaaaccgc cggctcaaag cggaagagca 2124361 ttttgatcag gctgagaaat attttgaaaa gttcgagcag accgcaaatg accgggaaaa 2124421 catctggaat atcaccggcc gcagtgaaat tcttgaaaag gtgaaggctt gtatcttatc 2124481 tgccaaaaaa agaatcctct tagaaatatg gaaagaggat tttaaggaga tagaagcaga 2124541 gctcaaacag gcggcagaac aaggcgttat tgtcaccatt attgcgtacg gagacatcgt 2124601 atctgatttt gccaatgttt accttcatga tatgagcagt gaaattacag aagagtatga 2124661 cggacggtgg cttgtctata gcggagatga ttcagaagta gtagcgggca ttgtctcact 2124721 tggcaacgac agccgtgctg catggacgat gcatgtaggg ttagtcatgc ctattactga 2124781 agtgatcatt catgatctgt acctcatgga aattctgaaa aagcatagag agcttttaga 2124841 agagagcttc gggaaaaatc tcatccagtt gcgccgtaaa ttttctattc actcagattt 2124901 caaaaaacat tatttggaat aatgtttgtc atctcttacc ccaaaaacaa ggcttgtaca 2124961 aaacaagcct tgttttttta tgcataaacc ccccatgctg atttacttct ctcttttaaa 2125021 aaatgtgatt ctgcgcaaac tatttttcag cctgccgcgt ctatcctagg taacagccta 2125081 cgatatacgt atattcaaaa aggagccctt tattgcaatg aagaaaaaac aaacaacaaa 2125141 agcgttgctt gtcacatgca taactgacca taagcaagat ttctacaggt tggctttcag 2125201 ttatgtgaaa aatcaagatg acgcattaga tattgttcag gaatctataa aaaaagcgct 2125261 gagctcagtt gaaacggtca ggaaccctga gacgataaaa agctggtttt ataaaatttt 2125321 agtacggaca gccattgact ttttgcgcaa acaaaaaaag ataagagtga tggacgacga 2125381 aacgatagaa tttttaagca aaggaaagga agaccattac aaggatactg atctccatga 2125441 agcgcttgac gaattgccgt accgctataa aaccattatt attttacgtt tttttgaaga 2125501 cctcaaatta gaagaaattg cggaaattac aggagaaaac acgaataccg tcaaaacgcg 2125561 cctatacaga gcattgaagc tgatgcgcat tcagttgacg aaggaggatc tttcttaatg 2125621 gataagagat tacagcaatt aagagaagaa tataaaaatg ttcagattcc taaagaattg 2125681 gatatcattg ttgaaaaagc ccttcagcaa gaaccaaaaa agaaaagaat cgttatgtgg 2125741 ccgacatcag cagcaatcgc tgcagctatt ttattcactg cgcttgttaa tatcaacccg 2125801 gacgccgctc aggctatgtc aaagatccct gtcatcggca aaatcgtcaa agcgatcacc 2125861 tttattgaaa tcaaagagga aaaagaccaa tcaagcattg atgtcaaaac acctgctttg 2125921 tccgggcttt ctaataaaga gcttgaaaac agcattaacg agaaatactt gaaagaaagc 2125981 cagcagctgt ataaagagtt tatacagtcc acatccaaaa acaaaaaagg gcatctcagc 2126041 atctacagtg attacgagac ggtcacagac acgccagatt tactctctat ccggcgcaat 2126101 attgaaacaa cacaagcatc ttcctacaca caaagccgtt atattacaat tgacaaaaag 2126161 aatgatattt tacttacatt aaaaagctta ttcaaagatg agcgctatat caaagtcatc 2126221 agtcaaaaca tcaaagaaca aatgaaacag caaatgaagg aagatccaaa taaaatatat 2126281 tggctcactg acgaagatgc agaaccgttc aaaacgattc ttcctgatca gacgttttac 2126341 attactgaag accataaact tgtgatctca tttgacgaat atgaagtcgc ccccggctat 2126401 atgggcgtta cagagtttac aattccaacc ggcgtcattt caaacttgct cgtgggagaa 2126461 cgttatattc gataaaataa aaacatccat ctaagattat ggatgttttc tctcttctct 2126521 attcgaggtc gtaaccccgc tatcaaaaac aacgagaata tttgcatact attggaggaa 2126581 tacccatgta tcacaagaca cagcatcatc gatacattcc tggacttgat ggccttcggg 2126641 ctttcgccgt cctgtcagtt atcacttatc acctaaattt caattgggct aacggtggtt 2126701 ttatcggggt tgatatcttt tttgttttat ccggatattt gattacatct attctattac 2126761 cggcatatgg aaatgatatc aatcttgatt ttcgggattt ttgggtgcgc cgcattcggc 2126821 ggcttctccc ggcagcgtac cttatgatct tttccactgt tgtgtgggtc gtattgtttg 2126881 atcgagaact attgcacact gtacgtggag atgcgatctc ttctctcttt tatatgagca 2126941 attggtggtt tatttttcac aagctatcat attttgatag tttcggttcc ccatcacctc 2127001 taaaaaacct ttggtcgctg gcgattgaag aacaatttta tatcatatgg ccgatgtttt 2127061 tagttgttgg aatgtacata atgaaaagcc gcgccagatt ggctgcggtg atatcattgc 2127121 ttgtgctttg ttcagccgtg atgatgagcg tactgtatga acctggcgga gatccgagcc 2127181 gcgtttacta tggcacagac actcgttcgt ttgaacttct catcggatgt gccttggctt 2127241 tggtatggcc gatgaaaagg ctgtcttcca acaggctgcc aagcaaactg aagcacactt 2127301 tgcacgccac tgaatttttg gcattttgta ttttagtgtt gtgtgtctat ttcacagatg 2127361 aatacgagcc ttttctttac agaggcggaa tgctattcat tagcgtgact gccgcaatcc 2127421 ttattgcatg tgtttgccat ccgagcagct ttttaggcaa tctgctttca tggaggccgc 2127481 ttcggtggct tggaacgagg tcttacggaa tttatctttg gcactaccct gttattgtgt 2127541 taagcacgcc agttcaagaa atcggaaacc ctgttttttg gcatatcgtg ctaaaggtca 2127601 ttgtgacatg tatacttgcc gagctctcct accattttat tgagaagccg atacggacac 2127661 agggatttag gtcattttcc cgccgtgttt ttatacatag aatcaaggaa tggaaaacga 2127721 catctgtcat cagcaaaatg tcaattggtt tcattatttt cgctatactt atttttgcag 2127781 gcgggctgtc agggctagcc ggcgagcaaa agcaccctac caaatggacc tatagctcac 2127841 aagaaacaaa tgctgacacc agccaggctt ctggggataa aaagaacgct gcagcagata 2127901 aaaaacacaa tcctgaacaa aagacaacag attccaatca gggtcaaaag gaaaacaaag 2127961 atagtgggca agagactcat aaaaagaaag acacgcaatc ccaacagttg aaaaaaccag 2128021 cagacactgc gaaagaagtt ttagctatag gagattccgt catgcttgat atttcttcac 2128081 acctgcgtca gtcattttca aatgtgacga ttgatggaaa ggtagggaga caaatgtctc 2128141 aagctttgga actcgcaagg gaatacaagt cttttaatca gccgaacaag gctgtcatca 2128201 ttgagcttgg aaccaatggc tattttacaa acagccaaat cgaacaactg cttcaatctt 2128261 tctcaaaagc tcatatttat cttgtcaata cacgggttcc ccgccaatgg gaaagcaagg 2128321 taaatgaatc tttgcagcaa caggcccacg cacatcaaaa tgttacgtta gttgactggc 2128381 atacagaagc tcttcagcat ccggaatatt ttacccctga tggtgttcac ttggttccta 2128441 aaggggcaaa aactttgact gctcttattg ttcaggcgat gaaatcgtaa aaaagagatc 2128501 ctatacagat cactttttta ctttagtttc tgatcgttga ttatgtcttc tttcagcaag 2128561 gcagccctta tgtttacatg ccgtttacgt aagggtaagc caaaattgaa tggagggatg 2128621 ataatgaaag gaaatgaaga acatgacatc caaaaagagt tgaaacgata tgagcttttt 2128681 ttcaaaaaac gatataaggt tctttataca gtaaacgatt ttatcatcgg tgctatgttt 2128741 ctcgttggaa gttttttctt tttttatgac cggttaatgt cggcagggat atggctgttt 2128801 gcgatcggaa gtttgctgct gttaatcagg ccgaccattc ggctgattca tgactttcat 2128861 taccgtaagc atgtggaaca gcaattcaag catcaatctt caacagatga ctgatcttaa 2128921 ggaataagaa agaacaaaat gccaaaagcc tgagtcgaaa atcaaaaaca agactttcag 2128981 actatttatt tttaaaaaca aggtaaaaag aactaaactt ttgcctctgc atgccgatat 2129041 gaataataag gccggcgcga tactccctat aacatccttt tcagtagatt tcattatcgt 2129101 gccggttttc tcatatgcaa agcaatcccg ccaatcagat tggcgggatt ttatatttta 2129161 cattcctgtc caaacgtctt tcacataacg tctttgatct tgcagctttt gcagccatac 2129221 agctgattct tcctgacttg ctgctttttc agcttcatat gccaatcgca aagttctctc 2129281 tacatcagga gccatttgcg atccatcacc gcatacgtaa atatgagccc ctttttcaat 2129341 gagtgtcatc aatttctgcg tatcttgctt gagcaagtgc tggacatatc cttttggttc 2129401 gttttcgacg cgcgagtagc atcggcggat tgtgaccaaa ccgtcctgtt ccgcttgatc 2129461 cagctcttct ctgtaaaggt cgtcatggtc cgggcggcgg cagccgaagt ataaaagtgc 2129521 ttcaccaagg gtgcttcctt ccttcttcaa aaccgatctt gcctgaataa agcctctgaa 2129581 tggcgcaatt cctgtgcccg gcccgaccat aatcataggc gtttcaggat cattcggcat 2129641 ctgaaatccg gactgcggcg tacgaatgaa gcaagctgct gcatcacctg tattcaattc 2129701 tgctaaataa ttagaggcga caccccggta ttcacctcgg ccgctccatg ctgaggcttt 2129761 cacaactcct accgtcatgc tcacgatatt tgcatgaact ttcggtgagc ttgaaatgga 2129821 atagtatctc ggttttagtg atggcaaaag tgctaaaaac cgttcaaacg gcatttcgca 2129881 agcaggataa tcctctaaaa aatcaagcat ggtaagacgt tttgcaagta cctgctcttt 2129941 gtaaatgcca tcatctgaaa cgagctgttc cagctctttt tgatgcggcg gacaaactgt 2130001 ataagaggcc agctcccgaa gctgaagcct tgatgccggt tcctgcagct ctacatagga 2130061 cgacaataaa tccactactt tgattggccg atccatcggc agatgagcca tatgagcgct 2130121 tccgcttact tttatcacat gattggactg caaaccgaat cggctgagaa cccgctgaac 2130181 aagctccctg ctgttctttg gcaggattcc gatatgatcg ccttctttat atgttttacc 2130241 agccggaatt tccaattcaa tatggcgggt tgaacgcgtg ctggcagctg tctggagttc 2130301 tcgattctct aacacaatcc cttcaaacgc gccatatgct ttagcaaccg gcgtttccgt 2130361 cgcttcactg agaaaagtaa tcgataatga aggcctgtct tctttctggg ctatttcgtt 2130421 aatatcaaat gcgtccatcg tttccttcca gaagcggttt tcccaagact cgcggtggct 2130481 ttcaaaatca tcggcggcgt caccttcccc aatcgctgtt aaacgcgatg ccccctttgc 2130541 tttcatcatg tcatcaatca ggcggggaat ccgctgatac gtgctggccc agctccggtt 2130601 tccgcagccg aataccgcat aggaaacacc tttcaattgg ccttcctcaa gctctttcag 2130661 ccactctaca aatccggcag cattatcagg cggcgcccca ttataagaag ccgttacaat 2130721 gacgactgcc ccttcttcag ggagcttgcc gatataatca tcaagcggag ccgtttcagc 2130781 tgtaaagccc atctggcggc cttgagcagc cagttcaccg gctattccct cagctgtccc 2130841 aagatttgaa ccaaaaagaa caagtaaagg tgtgccgtgt ttaggtttgg tttcttttgg 2130901 ctttgtttct gctttgatgt ctgcctgttc ttttctctgt acattgattg ccgctgtttt 2130961 tcgcggtttc acagtaattt taaaatcatc cggcttgatc gttaatgctt ctttgatttt 2131021 tagttcgtag ccagtatggt ttatcaattc aaaatgcttt aatacaagac cgagaaccat 2131081 tgtcgcttct tgaagagcaa actgcatgcc aatacaagcg cgctgtccgt ttccaaacgg 2131141 cttatacgca tggtgaggga tacttgaagg atcctcaaac cgttccggac ggaaatcttc 2131201 cgcatccggt ccccaagcgt tttgatcccg gtgcagtttt ggaattaaaa cagtgactgg 2131261 ctgccctttg ctgatcggat attccccgcc tagaacagta tcctccttcg catatagaga 2131321 aaaagccgga gctgttggat acagtctgag ggtttcattt aaaaccatcc gaatgtattt 2131381 gagctgctgg atttgtttat attcaggcgt gtcatccgtt aacacgcgat ccgcttcctc 2131441 ctgagctttt ttcagttttt ccggatgtgt aagcagacaa taaatcgcaa aggatagcaa 2131501 cccgcttgtt gtctcatgtc cagcaattaa aaatgtgatg atttggtatc gaatgttttc 2131561 gtcatccagc gtttcacccg ttactggatc tttggcataa agcatgagag acaagagatc 2131621 cttaatgttt tcatccggat tcgcctttcg ctccgctatc attctatcaa ccagggagtt 2131681 catgacttct atatcctttt ggaactgcag cttcgttttc accatcattt tatcttgcag 2131741 gcccagtctt ttcgattgat tcatcgcctc ttttaaggca cggagcatac tggtgataaa 2131801 cggatgctgt gaatcacggt aaaagctgtt gaatcgatag ttaaacccgc ataacccaat 2131861 cgtatcaagc gtcagacgtg tcatatcgtc cgctacatca atttcttcat tagggtttaa 2131921 ccggctccac ttttgaatca gctgggttgc gatatccagc atcatagaat gatagccttt 2131981 catcgctttt tgactaaaac tcggcagcaa aatgcggtgg gctttttgcc agttcggttc 2132041 gtgcgtccag cttgtaaata agccatctcc cccgaactca cgcacctttt gcaagccttt 2132101 gccaaggttc ttgtcaaagc gtttttcatc acacacttca gccacaagat tgtggccgga 2132161 cacaaaaaca ctggatactc ccggaaaatc aaaacggaaa atcggtccca attcatcagc 2132221 tatccgccat aaggattgag aaagctgttc tttttccaga tgcggaagat tttttaaagg 2132281 tccgtatgtt ttgggctgag gtattgcgct tgcctgtttc attaacatct ccctttccta 2132341 tttttgtgat gaatgaagct taatggcgtc ccagcagcat tgttccaatt cagtaattaa 2132401 atcagtgtcc atctctatat cacctgtttg aacgagctga tatatcttga gaaacgcccc 2132461 taatacaatc gcaattaaca cattagaggg caggctgcga atcacgcctt ccgcttttcc 2132521 cttattaaaa tagtcatcaa gcatttgagt cagattttct atcatttttt tgcttgtatg 2132581 atttaagtaa tgagcgtctt ttttggtttc aagaaaaaaa agcgcatagt cgctctcttt 2132641 cgtaaactga acgagacagc aaaatacgtg gtgaaagcct tctctgacag gcaattctga 2132701 aacgtcttgc ttcagttttt ccgtaaatcg ctggatgctt tcttgaaaca gtacgttaac 2132761 gagtgtttct ttgctgtcaa aataacgata gatcgttcct gtccctacat gagcacgttc 2132821 agctatcata ggaatagtgg tagcgtcaaa acccctttcc gtaaaaagtg agactgacgc 2132881 tttcataatc atgtcgtatt tactgctgga tgcggatatc atgtaatctg acaacctccg 2132941 attcgtttac ggaatgaata ttcattcctt ttgttcacaa agaatgtctg ccctgtctga 2133001 tatcacctct ttgttctttc ttctgttata agtttatatg aaaaaaactt tttttaatat 2133061 aaagtatatg caaaaaataa aaaattaaga aaatataccc aaatcctaat acgaggatct 2133121 tggatatatt tcccgagaaa ttttttattt aacagccaca atacatagac aggaagcacg 2133181 cctgataaca gaaagatccc tgaaatgctg gtctttcagc agttgaatat acgttttctc 2133241 tttttcaccg gtatttgtgt caatactgat ataaaaccgg ccgtcaattt gaagcaccct 2133301 gtaaatttct cttaatgcaa gcctaatatc ggtgcagctt tgaaccgtat gtaaagaaaa 2133361 gactttatta aaggtacggt catcaaaggg aatgtcctct ggatagccat gaaaaacctc 2133421 cccgttcccc atgttctttc gattcgcacg tgatatctgt cttacctttc gttttgaagg 2133481 atcaatgctt tttaggctac ccttttttag tttcttggtt atgcttttaa agacagtgcc 2133541 gtttccaatt ccaatttcta aaattctgtc attttcttgt atatctatag agtcaatcat 2133601 catatgctca attgttttgg ttagcttata tttccgagaa aataatttcc aaaaatccga 2133661 tcgtttatag agtctatttt ctagcatttt aaacacctgc ttttggtttc ctatgtttat 2133721 ttattatctt aaaaaaataa acatcatctt catttctaaa agtgaaggaa ggtaccaact 2133781 agacggcaat gtattgaaaa atgtttcaat agaactaaac tttttcattt ttttccgaaa 2133841 aaaaagcaga aaacataatg ttttctgccc tctttctaat gccaatgata agggaataca 2133901 tacagccttt gctgctgcat tgccatcagc ctctgctgtc ggaatggatt tccataacca 2133961 tgtttgaagg aatgcggcat ggacgcataa ccatggccaa tcgacggcag tcttttttga 2134021 taatcgttca tcatgccatc acctgcctca caataacgtt gatttactat atgcaggcgc 2134081 gcattttctt gacagctatt tcgctaaact tggtccttct ccattgtata atgcatcaat 2134141 agttccattc taagcatatg ccattccccc ttcagttttt ttcgttgctt ttagcgccag 2134201 tttgttaaat aaagatgctt taactgagac tctttcattt catcataaat ttgttcaatc 2134261 tgctgttctc gttcgaattc ttccaggctt ttaaaccgtt ttttaatcgt taacgttaaa 2134321 aagaataggt taatcgtcat atcgctcacc ccctttcaaa gtccgcatca agcgaaataa 2134381 cccgcggcac aacccttctg ccgcgggcaa ataaaaaccg cagacaaaag aagacaccaa 2134441 tgcctctact gcctgcgggg agttgcgtat gtccgactat tccgaattta atgcgtgcga 2134501 taagcatcgg ttaaggaagg acacgaactc ttccacaggc tgaataaacc atgaactttt 2134561 acatgtgtat cacgtacagg ttgacgtcgt tgtctcattg tcattttggt tcagcctcct 2134621 ttgctttttt cttactttgt aagtatatcc accaaattcc attttgtaaa catctttttc 2134681 taaaaatgga cggaaattgt gcaaatcatc gaatggattt gcccgttggt catgacacct 2134741 gcttcatttc ttttctggag cggtctttct tatgatatgc aataaaataa atgagaccga 2134801 caaatacagc tccgccgatg acattaccga taaaagccgg aatgatgttt ccgatgaact 2134861 gcccccacgt gaatgagcct gcaaaaatgg cagcaggaat cacaaacatg ttggcgacaa 2134921 cgtgctgaaa tccgatagcc acaaaagcca tgattgggaa ccagatgcca aggatttttc 2134981 ctgctgcgtc ttgggcgccg aaagaaagcc acactgcaag acatacaagc cagttacagc 2135041 cgatggcgga aatgagaacc ttgccaaagc tcatatcaag ctttccttgg gcaacggcaa 2135101 tcgttttttc taaataagga cctgtttcag tcaatccaac caaatgcccg aaaaagtaag 2135161 caacaaacaa tgcgccgatt aagttcataa ttgtgacgat tccccagtta atcgctaact 2135221 cttttactga tatttttctc gaaaataacg ccatcgcaac tgacatcata ttgcctgtga 2135281 tcagttcagc gccagcgaga acgacaagga tcaggccgac tggaaatact gctgcaccaa 2135341 tcaaactgga caggctcccc cattctttcg gaagatcgcc aattaccctg atatcaagca 2135401 aatacccaag cgcgataaat gcaccgccta aaaaccccag cacaagcagt gacggcagcg 2135461 ggagctttat ttttttcatc cctgcttcaa ttgctgcttc cgctatttca tccggttttc 2135521 gaaaagccat aataaaacgc ctccattact tcttcttttc tcacagttat gcaagaaagg 2135581 caataaaaaa ggcagcactc aaataacctg tgtcaaacca ggcgtttgaa tgctgcctaa 2135641 cttgtatgca tacccataca acaatatcaa gcagtatata agatattgaa agagaatata 2135701 tacagttcgt gcatacattc cattgcttta gccttctata actgtagcaa catcatatca 2135761 aatgtgacaa atttgtgtca atgacaaata tactagcttt gcagagcttc tttttgctca 2135821 tctatttttc ggtcaaaaac aaatacagat acagcgatgt tttcctcaat tttaatatca 2135881 gaaaacaaat ggactagctt agctcccata agttcctcca ttccttccgg tgtttgtttg 2135941 gaataaaggt cttgaattag gcttgtccgg gccgcatgta ccatctctct tccttcaggc 2136001 gtgcgggcaa taaactgctc gcttgcactc agatttccgt atagtgttga aactgccatg 2136061 ttttctacaa atacagtatg aattctctca ggcccttttc cgaacaattc tttgcgaagt 2136121 tttcgaataa tatcattgaa ttcatgaatt tttttagaca tgctgattac cccttccgat 2136181 attgccttat aaaggctttt cccggttccc ctcaggacat ttcacttggt taaaattttc 2136241 ctgccatatt gtattataat aaatatcaca ttataataaa agcagtgttg atggatttgt 2136301 aataggatct tgttatgagt ctatcgtttt ataaaaatca aggattggtc tgttagtaag 2136361 acttgctagt gaactattcc gccatgtgtg tttacacctt cttagaatta agggcaggtg 2136421 tatctataca tggctttttt tgacttcttg aaagaaagat ggaggggaat atgaatatga 2136481 tggacgttaa gtcgatcagt gtccgtgtag acggaacaga aattcaagca cgagcagggg 2136541 ccacaatttt agatatttta aatgaaaacg gaattgagta cccgcagatt tgccacgtac 2136601 cagaggttga cccgattcaa acttgtgata cttgcatagt agaggcaaac ggcaagctgg 2136661 ttcgttcatg cgcgacggtt gcagaaaacg ggatgtctat tgatctttca ggaaatcgag 2136721 tgaaagaagc gcaaaccgaa gcgatggacc gccttcttga aaatcatttg ctgtattgta 2136781 cagtttgcga taacaacaat ggaaactgta cgctgcataa tacagcggaa atgatgggga 2136841 tcgagcatca aaaataccca tacacgccaa aagaagatcc ttcttgcgcg gttgatatgt 2136901 ctcatccttt ttaccgctat gatccaaacc aatgtattgc ctgcggccag tgtgttgagg 2136961 tctgtcaaaa ccttcaggta aatgaaacac tctcaatcga ctgggaacgc gaacgccctc 2137021 gcgtcatttg ggatgaggga gttccgatca atgaatcttc ctgtgtcagc tgcggtcagt 2137081 gtgtaacagt atgtccatgt aatgcactga tggaaaaatc aatgctcggg caggctggtt 2137141 ttatgacagg cattaaagag gacgtcatgg aaccgatgat tgatctcgtg aaaaatgttg 2137201 aaccggggta tggcagcatt tttgccattt ctgaagtcga agcggcaatg cgtgaaacga 2137261 gaacgaaaaa aacgaaaact gtatgtacgt tctgcggtgt cggatgttca tttgaagtat 2137321 ggacaaaagg acgggatatt ttaaagatcc agcctgtttc tgatgctccg gttaacgcaa 2137381 tttccacatg tgtcaaaggg aaattcggct gggattttgt caattcaaaa gagcggatca 2137441 caaagccttt aatccgtaaa aacggagcct ttgtggaatc ttcttgggaa gaagccctcg 2137501 atcttgtcgc aagcagatta ggatcaatta aagagcagta cggtaaaggc tctgtagggt 2137561 ttatttcttc ttctaaaatt acgaatgaag aaaactacgt cattcaaaaa ctagcgcgtc 2137621 aggtatttga aacaaacaac gtcgataact gctcacgcta ctgccagtct cctgctacag 2137681 acggattgtt ccgcactgtc ggcatgggcg gtgacgccgg cacgattaaa gatattgcca 2137741 aagcaggcct ggtcatcatt gtcggtgcca atccggcgga aggacaccca gtgctcgcaa 2137801 cacgcgtcaa acgggcacac aagctccacg gtcaaaaact gattgttgct gacctgcgta 2137861 aaaatgagat ggctgagcga tctgatctgt tcatcagccc taaacaaggc acagaccaag 2137921 tttggctgat ggctgttacg aaatatatga tcgaccaagg ctggcacgat caggcgttta 2137981 ttgatgagaa cgtcaattac tttgaagatt ataaagaaac ccttaaaacg tatacgcttg 2138041 attatgcaga acgcatcaca ggcctttcaa aagaaaacat cattcaaatt gctgaaatga 2138101 ttcgtgatgc tgacggcact tgtgtccttt ggggaatggg tgtcacacaa aatacaggcg 2138161 gttctgatac atcagcagcc atttcaaacc tgcttctcgc tacgggcaac tatcgccgtc 2138221 caggtgccgg cgcttatcct ctgcgcggac acaataacgt gcaaggcgca tgtgatatgg 2138281 gaacattgcc tggctggctg ccgggatatc agcatattac agatgacaaa gcacgcgcta 2138341 aatttgaaga ggcatatggt gtcgagattg atggaaagcc tggtttagat aatattcaaa 2138401 tgcttcatgc cattgaagaa ggaaaaatga aagctatgta tcttgtcggt gaggatatgg 2138461 cactggtcga ttcaaacgcg aaccatgtgc atgatatttt atcaagcctt gatttcttcg 2138521 tggtacagga catcttcctg tcaagaacag ctcaatatgc tgatgtcgtc ttgccggcca 2138581 ctccttcact tgaaaaagac ggaacattta ccaacacaga acgccgtgtc cagcgattgt 2138641 atcaggcgct tccgacgctt ggtgacgcaa aaccggactg gtggattatt caagaggtgg 2138701 caaaccgttt aggagcgaat tggaattaca gccatccaag tgacattttc tctgaaatgg 2138761 cgagtctttc tcctctgttt gccaaagcaa gctatgaggt gcttgaaggc tggaacagct 2138821 tcctatgggg cagcttcaca ggtgaaagca caccgcttct gtatgaagac ggatttaatt 2138881 tccctgacaa aaaagcccgc tttgcccttt ctgattggac cgagccagcg gcatttccgg 2138941 aggaatatga ccttcatatc aataacggcc ggatgctgga gcatttccac gaaggaaaca 2139001 tgacaaataa atcgaaaggc atccaagcga aagtgccgaa tgtattcgtt gagatctcac 2139061 ctgagcttgc acaagagcga ggtgtttgtg acggttcgct tgtacggctc gtttctccgt 2139121 tcggagcagt caaattgaac gcgctgatca cagaccgggt acggaaaaat gaactctatt 2139181 tgccaatgaa ctcgacagac aaggagtcag cgattaactt cttgacgggc cctgcagctg 2139241 ataaacggac gaacacgcct gcttataaac agacaaaggt ccgcatggaa gtgcttggcg 2139301 gctgtgaaac agcgccgctt ccaaaaacaa atccgcgcaa caaaaaacgg catccgcaaa 2139361 acggagtcga agcagaaaga aaatggaacc gccctggcta tgtacatctg actgattaaa 2139421 cgataggagg aaaacgaatg gccactccga ttacgacgat caaaaaagaa acaaaaacag 2139481 ctgagcaaat taagcttgaa aaaatagaag aactgaaaga gctgctggcg gaaaatgagg 2139541 acgccgtctc taaaacgatg acgttaatga atgaactcaa tgatcttgga atttttgatg 2139601 cggcaacaag catgctcaga gcgaaggaag acattgccaa gattgcgctt ggccaagttt 2139661 cccgcgagcc tgtcaccaac ctcatcaaca cgatgatggc cgccggaggc gcattgacaa 2139721 aagccgatcc tgagtttaca gcaaagcttt tagaaagcgt aatggctggg actgaacagg 2139781 cacaaagctt tttaaaagaa gacaagaaag tcgggattct cgacctgtta aaagcaatga 2139841 acgatcctga catcaacaga gccgtcgggt tcggccttca gtttttaaaa ggcatgggaa 2139901 aagaacttcg agaacaataa cagaaaaaca gccatctctg atgatggctg tttttttatt 2139961 cgtcggcttc ttccagacgc ttcttgtaaa taagtgaacg gtcagcgcaa aagaaggcac 2140021 cggctaaaaa tacgcaatcc gctaaaaaca tcgtcgattt ctggcctaat gttaagcctt 2140081 gatcagggag aactgcgcct atatataaaa aagtgctgac tgcaagcaat gtaaaagcaa 2140141 aatgcttgta gtcttctttt aaagatttca ttctattttt gttcaaaaga atcacctgcc 2140201 agattcatag tatacgacta ttataatata atccggcggc ttacagagaa agtaattcta 2140261 tccatttgtt atatattttc aagcgcttgg ccgatatctt ccaacaagtc ttccgcatct 2140321 tcaattccta cagaaattct gatcaagccg tccgtaatgc cgagctcaag ccggcgttct 2140381 ctcggaatag aggcatgtgt cattcttgca ggaacagaaa ttaagctttc aaccgccccc 2140441 aggctttcag caatggtaaa cagtttcaga tttcctaaaa acgcatcaac ccgttcttca 2140501 ctgccaatat caaaggagat catgccgccg aagcccgctc cttgcgtttt tgcaagctca 2140561 tgtccgggat gatttgaaga accagggtaa tataacgttt ggacagcagg gtgattctca 2140621 agaaagcttg cgattttccg cgcattttga tcgatcgctt ccattctgag tcccaacgtt 2140681 ttgattcctc tcattaacag ccaggaatct tgagggccga gcacgccgcc tgtggagttt 2140741 tgcacaaaat gcagctcttc tccaagctct ttcgaagctg tcacaactaa acctccgacg 2140801 acatcactgt gtccgccaag atattttgtc gcactgtgca gtacgatatc agcgcctaaa 2140861 gtaagcggct gttgaaaata aggagtatta aaggtattgt ctacgataag cagaacaccc 2140921 gctttttttg cgatatcagc catgagcgtc aggtcggtga ttttgagcaa cgggtttgtc 2140981 ggtgtttcaa tataaattgc ttttgtatta gggcgaatcg ctttttcaac ttcttccctg 2141041 ctgctcgtat caacaaatgt tgattcaatg ccaagacggt taagcacctt tgtcatcacg 2141101 cgatatgttc cgccgtacac atcatcagtc aacacgacat gatctccgct gttaaacagc 2141161 atcataaccg ctgtaatggc agccattcct gagctgaacg catagcctgc ttccccgctt 2141221 tccagttctg tcacaagtgc ttcgagagcg gttcgagtcg gattggccgt tcttgaatac 2141281 tcgtagcctg tatgctgccc tgctttcggc tgcttgtacg tgcttacttg ataaatcggc 2141341 acggaaactg cgcctgtttt ctcatcacct gtgattccgc catgtatcat caatgttttt 2141401 ttcttcatat cagatgcctc cttcgtatat ttgtttgctg atatatcgat cgctgctgtc 2141461 aggaaatact gtgacaatgt tagttccagc ggatgctttt ttcgcttcct ccaatgccgc 2141521 ataaagcgct gcacctgaag agcttccgat cagcaggcct tctttttctg ccgcttcttt 2141581 cacaagtcta aacgcattct catctgttac ggtgtagatc tcgtcaaaat ggctcttatc 2141641 catataatcg gggataaact ccatgccgat gccctctgtt ttatgagcgt ggggctctcc 2141701 tccgtttaaa atcgagccca ccggttcaac aatcaccgtt ttgactgctg gatttttttc 2141761 ttttaagaag gaagctgtcc ctgcgaatgt gcctcctgat cctgcccctg cgacaaatgt 2141821 atgaatattc ccgtcaagcg cttcccacat ttcaggtcca agcgtcttat agtaagtcga 2141881 tggatttact cggtttttaa attgcaaaac gcaataagaa ttttcaattt cagtctccag 2141941 ctgaatggct ttttgaatgg ctccctgcat tccgtcttga cgcggtgtat gaatgattga 2142001 tgcgccaagc gcttgcataa tttgctgttt ctctctgctg aaatgttcag ggacacagaa 2142061 aatcgctttc agcccatatt ttctggcact taacgcaagg ccgatccctg tattgcctgc 2142121 cgtagcttct ataatcactc cgccgggttt cactttgcct gaatcgagcg cgtcacgaat 2142181 cagcatatct cccagtctgt ctttgatgct tccccctgga ttcatcattt caagcttggc 2142241 atacaccgcg actccttctg gaacatcaaa gttcttcaag cggagaagcg gtgtattccc 2142301 aatcagctcg gtaatgtccg taatcactgt catatatgtc ctcctcctta atagaggttg 2142361 tttttagaga aaaacggagg agaacgttct ccccgtttta atgaattcgt ttgatcacct 2142421 ttaacacaag ctctgttgaa tgaacagccg cctgctctaa aaattggtca aatgaaacat 2142481 gtgattcttt gcctgcgata tctgataacg ctctgatgac gacaaacggc gttttaaatt 2142541 gatggcatac ttgagccact gccgcagcct ccatttcaac cgcgtacaga tcagaaaatc 2142601 tcgcacgcac ctcttcaacc cgcttcggat cgttcatgaa agaatcgcct gttgcaatcg 2142661 ttccttttgc aacctgaatg ccgtcgagtt cagataccgc ttcttcagtg atgctgatca 2142721 gcttttcatc cgccgcataa gcagccggaa gacccggcac ttggccgtat tcatagtcaa 2142781 aagccgttac gtctacatca tggtggcgaa cgtcagtgga aatgacgaca tcccctacat 2142841 tcaatgtatg atgaaatccg ccggctgagc ctgtgttaat gacataatca ggcttgtaac 2142901 ggtcaagcag aagcgtcgtg ctgatagcag catttacttt tccaattcct gattttaaaa 2142961 gaatcacttc agttccttca tattcgcctg ttgtaaattc acagtgtgcg atcgtttctg 2143021 tttttgcatt ttcaagtttg tttcttaaga tggtaacttc ctcttccatt gctccgatga 2143081 ctgctagtct catctattca cattcccttc actttaccgt ttgatcgcct ccattatcca 2143141 cacgaagtcg ttttgctgag tgaatcggac tgcaaaacct tcagctgtaa acatttcttt 2143201 caacgcatcc aatgtaggat aatgctctgt ctctaaatca tttgcaagct gataaaagcc 2143261 ttgagaacgg gctttatcga tagcctgttg atacgcttgc gcattttcaa agacggtatc 2143321 ggcaaacact attttatcat gcaagtgaag gtatttgcca tattgcttta tggcagcccg 2143381 cttttcttcg tcagtcaaat gatgaaaagc atatgaactg acaatcgtat cagcctgaaa 2143441 tggcggctca gggaatgtca ggaagtctcc atcaacgatt tccgtcctgc ctgagagctt 2143501 gtcagaagcc agtttacgca ttgctggaga aggttcgatt ccaaatacag ttttgcctgc 2143561 atcgagcagc ttagctgtca aattcccggt ccccgggcca aattctaaca catgcgttcc 2143621 agattttctg acgatggcat caaggatatg atcgtagcct ctgaacgctt ctttatactg 2143681 aatatctaaa ccttgtactg tttgatcata agttgctgcc caatcttcaa agagagggat 2143741 aaattcacgg cccatatttg tcacactcca tatttaataa ttcctataag tatactatgg 2143801 attaatgatg gaacagttcc tataatacca catattctga aaagcaggta ctaaaacact 2143861 ttgtgtattt tatgccatct catattgcgc attgaccgca aaaaagctta tacttcatat 2143921 gacttgtgaa agctggaggg tcaagacatg aattttcaat tagatctgat taaagacaaa 2143981 gtggaatttt ttgaagcggc ttcattgcag gagcttgaaa agaaaatcaa tacacaaatt 2144041 gaaaacaata aagccatcat gctccgggtg aaatctgttt cacaccaaac tcttgtggca 2144101 gaaggaagaa tattgtacag cgcggtggtt catttctcag ctgaagccta aaacaaaagc 2144161 agccggtttt aacccggctg cttttgttta ttttagcttt tctacttttg tcggcttcca 2144221 gcctttttca tcgacccatg taatcgtgac ttgatattta ttcccagtcg ccttgtccaa 2144281 aatcttgcct ttggcatcct gagggctgcc gttatttcca agccagagca ccgtcatgtt 2144341 atctgttgag acaccagttg cgtacgaaat ggctttcagc atctcagccc agtcttgtga 2144401 gcttgaatca taagtagcgg catgctcgcc agtctgctca gttccgactg ctttccagtc 2144461 aggattttca tacgtttttt ccacatcgct cgatgagccg ccttctgtta cttttgcatc 2144521 tttaagcccg tcaccggctg aatctgagct tgaatctgaa tcagagtcat cttttttaga 2144581 agaagaatca tcttttttgg aatcagagtc agaagacttc tcagaatcct tttcgctgtc 2144641 agatgtatct ttcttgctgt cttttatatc ctcatccgat ttcttttccg tctttcctga 2144701 agccggagat tcctgttttt gcgccgtttc agaatccttg ctgacatctt tgctagaagg 2144761 actgttaatg aagagattcg ctgctactac gacaattagt atggatacga ttgcgattaa 2144821 aatgttaagc actaaattgg cttttctgcg tttatcacga ttttcataac gagattgatt 2144881 attgctcaat aattctgcac tcctttatcc ctcttggctc agcatatatt ttaacatgtg 2144941 ctgagaagtt gttctatttc tgattgattt caatttcgtg tactttttta acaatatcat 2145001 aaaacaccga atttgtcaga gccttatctc ccggtgtatc catgtgtaaa acaactagag 2145061 cgtatttcgg cttatccgcg ggaaaatatc cggcaaacca tttttcgtag agcgtttcct 2145121 tctcttttga aagcttgcct gtctgggctg tgcccgactt ccctgctaca gtatacggaa 2145181 gatcttgaaa ccttctgccc gttccggaag gagattctac tacccgccgc agtatttttt 2145241 gaagctgctg tgacgtatat ttgtctatcg tttccccttt gagcttctga tctttaaacg 2145301 taacgagcgt tgtgccgttc ttatactcaa tttgttcggc aattttcacc tgccgttttt 2145361 ctccgccgcg ggcgattgtc gccatcatat tggctacctc cagcggcgtt acctttacat 2145421 ttttctgccc gattgctgtt tgcgcaatgg cttttttgac tgatttgtct ttttcatccc 2145481 cccaaatcac gccgcttttt tcgttataca gctggcggaa atcggtttcg tggtacagtt 2145541 ttccctccca gcctgcccga tcagtgagag ccagcttctc ggacatatct tcaataaccg 2145601 agctgtcttt tttcattaat tgttctgcaa gactcgtaaa tgtgtaatta cagctttggg 2145661 caaaactttc atcaaaagac aaggtgcctt tgtcgtcccc cggttccccg tacaggttta 2145721 aattgcaatt aaaggtttga ctaggcttca ccatattatt ttcgattgca gctgcggcaa 2145781 tgactgtttt aaaaactgat ccgggataga ttggcgtcag catataattt tgaagtgtgt 2145841 tttgccggga cacgtctgca tctggtttgc ttacaattcc cagaacactg ctattttcga 2145901 tgtccagcag cacagctcct ccctttttca gcccctgttc atccaatacc tcctccatcg 2145961 ctttttgaat gctttgatcg atcgttgttt tgatctggag cggataaaat gtattggctt 2146021 cagctgtata tttgacgtcc atgccaaaca aagggtttcc ttttccgtcc acatgatata 2146081 aaagctttgt gtcttgttcc ggaagcaaaa actcgtcaaa tgtccgttct aaaccggttg 2146141 ttccgatttc tgttgtaatc ggaaggctct ccttgtcagg atatttcttg cgaagcagcg 2146201 ccggatcttg gttcgtgctc cctatcgtat gtgaagcaag gctgggcttg tcttcattct 2146261 ccatatatac gccgtaaatg ccgggatatt tcaaagaatt gatttttgtg atagattgtt 2146321 ttgaaagtgt tttgattttc ttttgctgca aaatgaccgg tttttttgcc tgacctagtg 2146381 tctggcgcaa atcatcttca gacatgccga ggatgtccgc aacttttttg atcggccaat 2146441 cctgcgtcag cagaaaaggg aacaaaacaa ccgcaggctc gctttgtcct gtcagcgccc 2146501 gcccgtttcg atctaaaaaa gagcctcttc catctgaaat gagcacttcc tccgtccgct 2146561 gtttcacact ttcttgaatc aaattaattt tctttttaga aaatgattct gtgaaaaaca 2146621 gctggatttc tgcaagtctc agcagaagca gaaaaaatac aatcaaaaaa gcgatgactg 2146681 ccagcttcat tcgtttcgat atcttcataa aaaaacacct cacccacatt gtggacgagg 2146741 tgtttcgctg ctaaacagat attatgaaat tttcacaatt ttcacgagca tttctccgcc 2146801 cggtgtttgt actgtgactt cttcatctac ttttttgccc aagaggcttt ttgcgatcgg 2146861 tgaatcgttt gagattttcc cttcaaacgg gtcagcttcc gcgcttccga cgatcgtata 2146921 tgattcttca tcaccgtcag gcagttcgac gaaagtgacg gttttaccca aaccgacaac 2146981 gttagagccg ccgtcatctt caatgatttt cgcattgcga atcatatttt caagagtcgt 2147041 cacgcggccc tctacaaatg cctgctcttc tttcgctgaa tcgtattcag agttctcgga 2147101 aaggtctccg aagcttctcg caattttgat tcgctctact acttcttttc gtttaaccgt 2147161 tttcaaatat tctaattctt gttcaagttt ttgttttcct tctgcagtca taggaaaaac 2147221 tttctcttgt gccatgtccc ttcactcctt ctggttgtcc ctcaacatct tcgattatgt 2147281 atgagagcat aaactaaaaa atacaagaat gagaacacag ggcagtcctc gttcttctct 2147341 cccatatagg tactgtttat cttaaactga atcgtgtcgt tctgcaaata tttcgcgttt 2147401 ataaacaggg aaagaaggga attcgcacat tcccttcctg cctatacata atatggtcag 2147461 agttatttat gtctatgcta tggtattaca aaatcgcgtt ttgttcaaga atggtttgaa 2147521 tttttgtgac catcagatca attgcgacgt gattctgacc gccttccggg ataataatat 2147581 cagcgtatcg tttcgtcggc tcgacgaatt ggttatgcat cggacggacc actgacacat 2147641 attgttcaat gacagaatca atagagcgtc cgcgctcatt aatatctctc ataatccgtc 2147701 tgatgatacg caagtcagcg tccgtatcaa cataaagctt gatatccatc agatcacgaa 2147761 gccttttgtc ttcaagaaca agaatgcctt caaggataat aacatccttt ggctctacgt 2147821 gaaccgtttc ttctgaacgt gtgtgaagct tatagtcata aatcggcttt tcaatcgggc 2147881 ggtaattcaa tagatcttga atatgctcga ttaaatagtc attatcaaac gcaagcggat 2147941 gatcatagtt tgtgttcagc ctttcttcaa acggaagatg gctttggtct ttataataaa 2148001 ggtcctgctg gatcattaaa attgagtgtc ctttaaactg ttcataaatg gaccgtgtga 2148061 cactcgtttt tcctgaaccg gaacctcctg cgattccaat gactactgga ttcttaccca 2148121 tgggctgtta cttccccttt ctcatcatgt tgctcggata aatctttttg tctagtttga 2148181 atttgacaat ttgcagggga tggcgggcag catctagctc atttccgtct tcgtcccaaa 2148241 tggtttcaat cgtatgtgta aagttttcga tttctggacc gaaaaattcc acttcgtcgc 2148301 cttttttgaa gaaattgcgc tgctgaagcg tgaccatttg tgtatcttca tcataattca 2148361 gcactaagcc gacaaaatca tatgtcgttt tcttggcgtg ttcgccgaac atttgctctt 2148421 catagcctgg cgttccttca aagaaagctg tcgcagtgtc cctgttggcg cacttatcaa 2148481 gctcttcaag ccattctttt tgaatcacaa agttttctgg atcagcgcaa taagcatcga 2148541 ttactttgcg gtatacgctg acaacagttg ctacatagtg aatggatttc atgcggcctt 2148601 caatctttaa gctgtcgatc cccatttcaa tcatttttgg aatggattca atcagcttca 2148661 aatctttcgg gctcatcgca aatggtgcat cttcttcacc atacaaagca acggcgttgg 2148721 caccgtctgt ttggtagaga tcataatccc agcggcatga ctggcagcag cctccgcggt 2148781 tggaatcccg cgctgtcatg tgattgctca gcacgcagcg gccggaatat gcaatacaca 2148841 ttgcgccatg aatgaaggat tcgatttcga tatctacctt ttctttcatt tctctgattt 2148901 caagagcgct agtttcacgt gccagcacga cgcggtcgag accttcttcc ttccagaact 2148961 ggacagcctt ccagtttgaa agagactgct gtgtgctcaa gtgaacctca acattcggcg 2149021 ccactctgcg gcatgtttca ataataagcg gatctgccac aataataccg gcaacgttgg 2149081 cgtctccaag cgcttttaaa tagtcttcaa gcccgtccat gttttcatta tgagcgaaaa 2149141 tattcgttgt tacgtagatc ttcgcgccat atttctttgc gaattcaacg ccttctgcaa 2149201 tttcttcgat cgtaaagtta tcggcattcg agcgaagccc gtattcctgt cccccgataa 2149261 agaccgcgtc cgctccgtaa tgaacagcga ttttcagctt ttcaagatta cccgcaggtg 2149321 cgagaagctc cggctttttc gtaatcacac gctttccatt aacgattgtg gatattttat 2149381 catttacggc agtcatagct taacctcctt ttgattaata aaccgtttcc ttgaagaaga 2149441 atccggtatc aatttttctg tttactggct ggatgctttc aatgcgttcg atccagtctt 2149501 cttttttcgc ttcgtattcg tcacggtttt ccacgcacaa atcaattgct tctctgtaca 2149561 ttttggtgac ttctattagg tattcaggca ttttcaaaac accatcgatt ttgaaagaat 2149621 caattccggc atctatcaat tcctcgagct catcaatgat gcacacatcg ttcgggctca 2149681 tgatgtgagt gccgttttca tcttcgaaaa tcggatattt attatcgcgt tctttatcgt 2149741 gtaaaaacat gcctgattct tttttctttc tttcaatgtc catgactttg ccctgatatt 2149801 caaaatagtt tccaatcaaa gaacgcttcg attggaacat gcacgtcatt ccatgcacct 2149861 ggatttcaat ttcgacttca gcattttctt taatctcaac aatgctgtcc atgtttaatt 2149921 ctctggcaag cacagaacgc gccgcaccct tgcgtcccca gtagttgcat gtataatagt 2149981 tggtgcctgt cgtttctgtg ctccaatgaa gcttcagatc aggcgcagat tcacgggcag 2150041 ccatcagcac ggcaggatcg ccgaataccg ctgcatcgac accggcttct gctaagaaag 2150101 ccagatattc gccaagctca cccactttat cattatggaa aattgcattt acagcaacgt 2150161 atacttttgc cccttctttg tgagcaatct ctacggcttt tgttacatct tcacgagaaa 2150221 attctccggc taatctcaag ccgtatctct gttccccaac taaaaacgca gttgccccag 2150281 cctgtatgag cggcaaaatg tccgctgtac tcgtcggcgt cactaagagc tctggttttt 2150341 tcatgacgtt cacctcttct ttttactaat cgcaagtccg tccccgacag gaataatcgc 2150401 agtttgataa tccggatgat tcatcagcca atgattatat tcatcaattt tggctacaag 2150461 cctgcgcctt ctcttcggtt ctattttgct gtaatcctct gccaccagac ctttaaacag 2150521 cacgttgtct gttataatca ccccgtccgg tgaaagcatc ggttcatata aatgaaaaaa 2150581 gttttgatac tgaccttttg cagcgtcaat aaaaatgaca tcgtaaggcg cggttacatg 2150641 aacggcgtcg gctaattcaa gcgcatctcc gtaaaaaaca tgaatccggt catcaagctg 2150701 aaattccttg atattgttta ccgcttcttc atgccgtttc tcattgcgtt caattgtata 2150761 tatttcagca gacggcagtt ccagagccat tcgaatggct gaataaccaa tggccgttcc 2150821 gatttctagt atttttttcg gctgtttcac agacaaaatt tgaagcagca cctccatgcc 2150881 cgctttttcc ataatcggga catgatgttc ttctgcatat gcttcaagtc tcttcacgtt 2150941 atccggccga ggctttaata atgcttctat atagtcattt atttgttcat accggtcagt 2151001 cactacaaac agcctcccgt tctaaaaagg agtgccccag tcttatgcgc aggacactct 2151061 ctgaatacat catgatacat cggtaaacaa cccgatatat tttatcataa aaccttgcgg 2151121 aaagcgaaca aaaggagagc tttttgctct ccttttattt ctcatttttt gaggaaatgt 2151181 atttttcttt tgctttatta tgctctttta gcgtttttgt aaatacgacc tcaccatttg 2151241 atttggccaa gaaatacaga tagtccgttt tatccggatg cagcgctgct tcccatgatg 2151301 acatgccggc attggcaatc ggccctggcg tcagccctgt gtttttatac gtattgtatg 2151361 gtgaatcgat ttccagatcc ttataaagaa cccgatcttt atgcttgcct gccgcgtaca 2151421 ggacggtcgg atctgtttgg agcggcattt tctttttcag gcggttataa aagacgctcg 2151481 caattttatg gcggtcggct ttttcagtcg cttcttcttc tatcaaagaa gccattgtca 2151541 gcagcttatg cacagaaact ttgtttttct tcatttctga tttatatgtt tccacataag 2151601 aatttgtctg cttaatcatt gccttgataa tgtcttcaag tgatgtgtcc ggatcgttaa 2151661 aagggtatgt agccgggaat aggtaccctt caagcgggtg cttaatgttt ttattgaaaa 2151721 catcatttgt cacagtgtcc gggaattctt tcttcagctg attgataaat gtttcatcgt 2151781 ccagcttcgc tatgacttgt tttttagagt attttgtttc atcagcaata gcagccgcga 2151841 tttgggtcag ctgtgctccc tcagtcactg tgatttgaaa agcgtaacct gtagccccgc 2151901 ttgtcagctt ctgaataatg gcatctaaat ccataccttt attcagatgg tagaatccgg 2151961 cctgaaaccc ggaagcacct ttatatttca catagtactg aaacgccttc tcgcttttta 2152021 tgacatcatt tttctttaat atcgatgcga tggctgaaac agacgaaccg ctcggaatgt 2152081 taatattaac tgtcgtttta ctgtcttttt caacaggttc aagcaatgat ttcccatata 2152141 aaaatgcccc gccaatgatg agaaacagca caacaatgga agacagtatg attctttttt 2152201 tattaaaaaa cgattttttt tgctgattga tatacattag gtctcctccc atcagctctt 2152261 atactacatg attcattgta tttcggcaat ttattacaaa aagaggcctg cataaagcag 2152321 aaaaaagccg gagcagtata gctccggctt tggtttggcg cgatgtttta ctcttcgtct 2152381 tcgtccgcta agaatgtgtt tagtgtttct tcgatcatat cccattcttc gtcagtttca 2152441 atcgggaata gctcaccgtt ttcaccgtct tcgtttggcg tgaagctgga agcaagaatt 2152501 tctacttctt cgtcatcttt tgattcgatt ggatagtaca agacataaga tttgccaaac 2152561 tcttcatttt caaatgtaaa cagcacttca caaagctgtt catttccttg atcgtcaaca 2152621 attgtaatat ttttttcgcc gtgttccatt ttcttcacct ctggctttaa tttaagctgt 2152681 caagatatcc ttgtaaaatc ataacagccg ccattttatc aatgactttt tttcgttttt 2152741 gcctgctgac gtcagctgca atcagcattt tttcagccgc cattgtggta agacgctcgt 2152801 cccacagcac aacaggaaca ttgtacgttg tttcaagcac tttcgcaaat gtttggctgg 2152861 cttcgcctct cgggccgact gttccgttca tgttcttagg aaagccgagc acgattttat 2152921 ctatagtata gtcctttatc agttcagata aacgggataa accataatcg ccttctgctt 2152981 catttatctt tatggtctca atgccttgag cagtccagcc catttcatcg ctcagagcta 2153041 caccgagtgt tttggttcct aaatcgagtc ctaatattct cattctttat ttacgcctct 2153101 ttatgctgtt ctaaataaga ctttaccaat tcctcgatta attcgtctct ttcaagtttg 2153161 cgaattaaat tgcgagcgtc acgatgccta ggaatataag cgggatcacc tgacagcaag 2153221 tatccgacaa tctggttgat tggattgtag cccttttcct gaagcgcgtc atacactgta 2153281 atcagcacct catttacgtt agtctcagca gaatcatcgg agaaattaaa tttcatcgtt 2153341 ttatcaaacg agctcaccgt tttgcacctc tttcccaaat tcgcaggcaa agttcagcct 2153401 ggggtcctaa tcttaccatc attctacact acatgggcga attataaaac ggatttcacc 2153461 caatcttcta cagaagccaa agcttcttct aatttttccg gctgtttacc gcctgcctgc 2153521 gccatgtccg gacggcctcc gccgcctccg ccgcaaactt ccgcagcttg tttaaccagc 2153581 ttgccggcgt gaagtccttt ctcaatgagg tcctttgtga ctccggcaga gatattaact 2153641 ttatcgtttt gtaccgcacc aagcacgatc accgcagagc caagctttgc tttgagttca 2153701 tcgaccatag tgcggagatg attcatgtct tttgcattta cttttgccgc aagcacgttt 2153761 acgccgtcaa cttcttttac tttcgacagg attgctcctg cttccacgtt gcctagtttt 2153821 gcaagaagag attcattttc tctttgtgca tccttcagtt cagcctgcag agccgcgacc 2153881 cgtttcggca cttctttgat atttgttttc agctcgtcag cggtctgctt caatacagaa 2153941 atctggctgt tcatttcgac gtaagcgcct tgtcccgtta cagcttcaat ccgtcttgtg 2154001 cctgctccga ttccggattc agaaacgatt ttaaacaagc cgatttctgc tgtatttctg 2154061 acgtggcagc cgccgcacag ctctaagctg taatctccaa cttgaacgac acggacaata 2154121 tcgccatatt tttcgccgaa cagtgccatc gcacccattt cttttgcttc agcgatcggt 2154181 ttcaaatcaa tgctgaccgg gatgctcgcc cagatctttt cgtttacgat tctttcaatt 2154241 tgttcgagct cttcttttgt cacttggcca aagtgcgaga agtcaaaacg aaggcggttt 2154301 tccgttacaa gagagcccgc ctgattgaca tgagttccaa gaacatcttt tagagcctga 2154361 tgcaataaat gcgttgccgt gtggttttta atgacgccgc ttctcatatg gtcttcaact 2154421 tcagccgtaa catgcaggcc tttttgaaca gtaccgctct ccacaacacc ttcatgcaca 2154481 tgctggccgt tcggcgcttt ttgaacatct ttaattctta caactgcctg ctcgcttcgg 2154541 agatagcctt tgtcgccgat ttggccgccg ctttctgcat agaacggtgt ttcatcaaga 2154601 atgatttgaa cgctttctcc ttcatgagcc tcttcgatta attggccgtc ctgaagaagc 2154661 acaatgatat tggcatcagc tttggtttga gagtagccga caaatgtgct ttcaactgtc 2154721 acgtcgcgca gtgcgccgcc ctgcacctgc atgctgccga catcctggcg ggcgtttctt 2154781 gcccgttcac gctgctggtt catttcctcc tcaaagccct catggtcaac cgtcatgttc 2154841 tcgtcttctg cgtattcttc agtcaattca accgggaatc catacgtatc atacagttta 2154901 aacacatcag cacctgagat aacgctgctg cccttgtctt tttctttttt gatcatttct 2154961 gacaggatcg caagcccttc attaagggtc tcatggaagc gttcttcctc ggttttaatg 2155021 acttttgcga tgaaatccgc tttctctttc acttcaggat agaaatcagc catgatttct 2155081 gcgacaaccg gcactaaatc aaacatgaac ggacgatgga tgttgatcgt tttggcataa 2155141 cgcacggcac ggcgtaataa gcgtcttaat acatagccgc ggccttcatt tgacggcagc 2155201 gcaccgtcac tgacagcaaa ggcaaccgtt ctgatatggt cagcaatcac tttaaacgca 2155261 gtgtctttca cattgtcttt gccatatgtt tcaccagaaa tcgattctgt tgctttaatg 2155321 atcggaacaa acaaatcggt gtcaaagttt gtcggaacat tctggatgac agacaccatt 2155381 ctttcaagac ccatgcctgt atcaatattt ttctttggaa gcggtgtgta cgtgccgtca 2155441 gggttatggt tgaactctga gaacacaagg ttccatactt ccaggtaacg gtcgttttcc 2155501 ccgcctgggt aaagctccgg atcttctgga tcattaccgt atgcttcacc gcggtcgtaa 2155561 aagatttccg tattcggtcc gctcggccct tcaccgatat cccagaagtt cccttccaga 2155621 cggataattc tttcttcagg aataccgatt tttttcgccc aaaactcata tgcctcttca 2155681 tcttcaggat gaaccgtaac agagagaagc tctttgtcga agccaatcca cttgtcgctc 2155741 gttaaaaact cccaagccca tgtaatggct tcttctttga aataatcgcc gatggaaaag 2155801 tttccgagca tttcaaagaa agtgtgatgg cgcgcagttt tacctacatt ttctatatcg 2155861 tttgttctga tcgctttttg agcgtttacg attcttggat tttccggcac gacacggccg 2155921 tcaaaatatt ttttcagcgt cgcaacaccg ctgttgatcc aaagcagtga aggatcctca 2155981 tgaggcacta atgacgcgct tggctctacc gcatgtcctt tttctttaaa gaaatccaaa 2156041 aacatttgac gcacttccgc agaagttaag tgtttcattg tatttcctcc tctataaaaa 2156101 tcgaaattct cttcagtgac agcaaaaaag ccctccccct atgcaaacca acgtttacac 2156161 agggacgaga gctgtctcgc ggtaccaccc tgattacggg cattcatgcg cccgtcacct 2156221 ttaaccctgt aacgcaggat aagcggcagt gattaactgc actcaggatt agcttcctcc 2156281 gatcttctga taaagctcct ttcagcttat ggagcttctc tctttaacag ggcttcggcg 2156341 tactcagatc cgtcactcga gattcgtatg tattctacga gaaattatag acaagcggca 2156401 cgccgatgtc aatgctccgt cctcatccgc aaaaaatgga tcatcattac ttttaaaaca 2156461 gccgtcgcag gaacagccag aatcatcccg acgatacccg caagctcccc tccggcaagg 2156521 agtgcaagca tgataacgac cggatgcatt ttaaggcttc tgccgacaat gaacggactg 2156581 aggatatttc cttccataaa ctgcagaata aacaccgtaa tcaccacaac aagaaccgcc 2156641 ttgactgaga tcgtcatcgc aattaacaac gcaggaacag ctccgatgaa agggccaaaa 2156701 tacgggatga cattcgttac cccagagata aggccaagta tcagcggata cggaagccca 2156761 aatacccaga acgaaatgcc tgcaatcacg ccaagaatca agcagaccaa aagctggccg 2156821 cggatataat cgccaagcga atcatccaca tcccgcaaaa aggcgctgcc ccgctttctc 2156881 cacgacttcg gagtcaagta ccatactgtc tttttcatta actcaatgtc cttcaccata 2156941 taaaacacga gaaaagggat tgttgcagca attaagaagt aatcaagcac attgcggatc 2157001 ccgctgatcg caccctcgat cgttcccgca aaaaacgcct ccgtctggcg gatcatttta 2157061 tctatacggt gatgcatacc atcaggccag tcatccgtat ggttatgcac atgaagaaga 2157121 agcccgttat acgtttcggc aaacatgggt atattttctg acaaatccgt cagctgcacg 2157181 attaaaacag gcaccccttt atacaacgcc cagccaatcc cgccaaaaaa aagaacataa 2157241 atgaccaaga tgctcaaagt cctaggcaat cctttgccat gcagccattc tgtgaccgga 2157301 agcaataaat aagatataaa aatagaaatg atcaagggaa taaagatcgt ttttatgacg 2157361 agccaaaagg gtgaccataa catatcaagc ataaaaaaga catagactgt taacagaacc 2157421 agcaaacaaa tagccaccca caacaaaagc tgcaccggtt tttggagcat ctgctttcac 2157481 ctcacctata tcttttgagg tttacaagga attattcttt atgtttcttt agtcagtcag 2157541 aagtcatgga cattttttca cttttaattt tcagaaaagt ttgatcattt actttttggt 2157601 caaattttct gataggagga ttgcgatgat cacatttcaa aatgtaaaca agcattacgg 2157661 agattttcac gtgttaaaac aaattaatct tcaaatcgaa aaaggtgaag tcgttgttat 2157721 catcggccca tccggttccg gtaaaagcac attgctcaga tgcatcaaca gacttgagtc 2157781 gatcaatgag ggagtgctta cagtaaacgg caccgccatt aacgacagaa aaactgatat 2157841 caatcaagtg cggcaaaata tcgggatggt gtttcagcac tttcatttat atccgcataa 2157901 aacagtgctg cagaacatca tgctggctcc ggtaaaagtg cttagacaat cacctgaaca 2157961 agcaaaggaa acggcgcggt actatcttga aaaagtcggc atcccagaca aggctgacgc 2158021 ctatccttcc cagctttccg gcgggcagca gcagcgtgtt gccatcgcaa gaggactggc 2158081 gatgaagccg gaggtcatgc tgtttgacga gccgacatca gcacttgatc ctgaaatgat 2158141 cggtgaggtg ctagatgtca tgaaaacact cgccaaagaa ggcatgacaa tggttgtcgt 2158201 gacacacgaa atggggtttg ccaaagaagt tgccgaccgg attgtcttca ttgacgaagg 2158261 aaaaatttta gaagaagcag tgccggctga attttacgcg aacccgaagg aagaacgggc 2158321 ccgcttattc ttaagccgta ttttaaatca ttaaaacaga aatgggggag cttgtatgaa 2158381 aaagattttt tctttagcat tgatttcttt attcgctgtc atcttgcttg ccgcttgcgg 2158441 cagcaaggga tcaaacggag aagcctcaaa ggagagcaaa aaagatacgc tagccgccat 2158501 taaagacaat gacaaaattg tcttcggcgt aaaaacggac actcgactgt tcggtcttaa 2158561 aaatccaagc tcaggtgaga ttgagggttt tgatattgat attgctaaac aaatcgctaa 2158621 agacatttta ggtgatgaga aaaaagctca atttaaagag gtcacctcaa aaacaaggat 2158681 tcctatgctg caaaacgggg atatcgacgc cattgtcgcc acaatgacga tcactgaaga 2158741 acgaaaaaag gaagttgact tttctgatgt ctatttcgag gccgggcaat cgcttctcgt 2158801 gaaaaaaggc agcaaaatca agagtgtcga gaatcttggc aaaggctcaa aagttcttgc 2158861 agtaaaaggc tccacctcct ctcaaaacat tcgtgaaaag gcgcctgaag catctgtttt 2158921 agaatttgaa aactacgcag aagcctttac agcccttaaa tcggggcaag gcgatgccct 2158981 caccacagat aatgcaattt tatatggaat ggctgatgaa aataaaaatt atcaattaac 2159041 aggaaagcct tttacagatg agccttacgg gatcgccgtg aaaaaagggc aatctgctct 2159101 cgcgaaagaa atcaacgctt cacttaaaaa gatgaagtcg gatggcagat acgatgaaat 2159161 ttataaaaaa tggatcaaag aagacccagc tgaataacaa ccatcccggg atgagcaggc 2159221 gatgctcatc ccaatttgat aaggagtgaa taggcagatg aatgtgtcaa ttcttttcga 2159281 taacttcagc atgtatatgg acggttttta ccataccttg ctcgcaagtg ttatcgcgct 2159341 ggccggcagt tttgtcctcg gcgttgctgt agcggttatg agaataacag tctttaagcc 2159401 gctgcaatgg ctcgggaccg catatgtaga attcatccgc aacatccctc ttcttttaat 2159461 tacctttgtt ttctatttcg gacttccaaa cgcaggcctg aggcttgacg gttttcaagc 2159521 gggaacggtt gctctcacca tttatacctc tgcgtttatc gctgaagcca tcagagcagg 2159581 catccagtct gtttcaaaag ggcagatgga agcggcacgc tcgtcaggct ttacctacag 2159641 ccaagccatg ctccatatca ttttgccgca ggcaatcaaa atcgtcattc cgcctttagg 2159701 caatcaattt ttaaacttag tcaaaaactc ttcgattctt ggggttgtgg ccggattgga 2159761 tcttatgtac caagccgatt tagtttcgtc gagcacactc gttgtatttg atgtttatat 2159821 ttttgtggcg cttttttact tagtgctgac gattccgctt agcatcggtg ttaactatct 2159881 ggaaaaacgg ctggaaaaaa gctattgata aggagtgagt tacattggat ttcatcggtg 2159941 cttattcaca ggagcattta gcgtttttat gggatggctt tctcgtcacc ttgtacgttg 2160001 ctttcatctc catcattctg agctttttct tcggtttaat cgcaggcacc ctgcgttatg 2160061 cgaaagttcc cgttctttct caattgattg cagttctcgt tgaaacgatc agaaacctcc 2160121 ccttgctgtt aattattttc tttacgtttt ttgcccttcc ggaaattggg attaagcttg 2160181 aaattacagc tgctgcaatt acagcactaa cgatttttga atccgctatg ctatctgaaa 2160241 ttatccgaag cggactgaaa tcaattgaca aaggacaaat tgaagcggcg cgctcctccg 2160301 ggctgagcta tacacagacc ctgttcttta tcgttatgcc gcaagcgctt cgccgcatgg 2160361 ttccgcccat cgtaagccag tttatttctt tattaaaaga tacatcgctc gctgttgtga 2160421 tcgccctgcc tgaactgatt cacaacgcgc aaattattaa cggccaaagc gctgacggca 2160481 gttatttttt cccgatcttt ttacttgcgg cccttatgta tttcgcagtc aactacagcc 2160541 tttcactcgc agcaagacgc ctcgaggtcc ggcaaacata gaaaaggata ctctttggag 2160601 agtatccttt ttgcattaaa acattttcgt aattcttctt ctcatccgct tcatgcttcg 2160661 attattcagc atgtcagatt gagtcgccat tcggtacacg agagctccgg ctcccattgc 2160721 caaaagagaa gtcatcgtcc gattcatcct gcgcatctcc tttcatgatt aaaaattgat 2160781 gctgcgttca tcctcagaaa acaaatcatc caagctgctt aacgttccgt cttcttccac 2160841 ctgatgagtt gcaatcttcc ctttcgccac tgtcagttca ataaaacagc cccagcaata 2160901 atattggttc acgccgattt tgccgatatc cttacttttg caattcgggc atataagcat 2160961 acctcacacc tctatccgtt cagaacgatc tcgtctttcc gcacctcgac aagcgaatcc 2161021 gctctttgga tctggcgctt gcttcccgcc aggtcagaaa agaaaccgtc cgagagttca 2161081 tatgctacga ttatgcccct gtccaaacaa aagtatacat cttccagcat ccccaatata 2161141 tccccctctt gcgatttcac aagcttcatc ttcatctgct cgtatgtgaa gcatgatttc 2161201 ggaagaggca aaagctgttc tgaactgacc gaagccaata tgcggtcatc aaaaatggaa 2161261 gagatatcac acgcccgtaa tagcgcatga tgatgatgca aaaagcgttt ttgtgcaaga 2161321 ataaacccaa gacaatctcc tttcagagaa aaacaaatat cggaaattgt cccgagataa 2161381 ctagaagttc gttctgagta tactgggaat ccttctactt catggcatgt tctcaaagtg 2161441 tgatcaacca ccttttgttg aacaggctta ggttttgctt tgcgccttag actcatacga 2161501 tgaaatcaat tccactgcaa atgaaaaaaa actcccgctt gcacgggagc attttattgc 2161561 tgttcttctt tcataaaatc gaatggtgta atgccttcca tgccaatgtt ggcgtcgtgt 2161621 acgctgaacg ggagctcttt ttgcaaagct tcaagctcgg catccatttc ctcaacctgt 2161681 acggacagcc tgtttttcaa ggaggtctgt ctgacagttg catcattatt tttcacgccc 2161741 cactccagcg cctcctcttc cccgcataaa atgagaaatt tcttcgctct tgtaatcgcg 2161801 gtataaagaa ggtttcttct gagcattcta taatagcctt tcacaacagg caaaaccaca 2161861 atcggaaatt cacttccctg cgatttatga atagaacagc aatacgcatg ggtaaattga 2161921 ttaaaatctt ttttcgtaaa tgtcatttca ttgccgtcaa aagaaacgac ggccatgtct 2161981 tctttttctg tattttcctt tgcataaaat atcgacgtga tttcgccaat atctccgttg 2162041 aacacattgt tttccggctg attgacaagc tgcaaaattt tatctccggt tctgtagaca 2162101 acatccccga acttcaattc tctccgtttt tctttaggag gatttaaaat gtcctgcagc 2162161 atcacattca attcattaat gccggctttt cctctgtaca tcggagcgag gacctgaatg 2162221 tcctttgctg tatagccttt tttcaatgca ttggcgacaa ccttctcaac tacttctttg 2162281 atttgcgacc cgccgcagcg aataaaggaa cggtcctttg tcggggcagt caaattgttc 2162341 ggcagcaatc catttttcat ctggtgggca agctcgacga ttgatgaccc ttctgcctgg 2162401 cgatagatgt ctgtcagtct cacagtcgga atcacctggg atgccagcag gtctctgagc 2162461 acttgtcccg gaccgacgga aggcagctgg tcttcgtctc cgacaatgat gatttgtata 2162521 tgatcaggga tcgccttgaa caaatgattc gccagccata tatcaagcat actggcttca 2162581 tcgataatta acagcttccc ttcgatcggc tgatcctctg tatgagtaaa gccttcagcg 2162641 ccgttccagc caagcagcct gtgtatcgta actgcaggga gtcccgttga ttcactcatc 2162701 cgttttgctg ctctccctgt cggagcggcc aaaacaatcg gaaaagcttc atccttttta 2162761 taagctgacg ggtctagtga cacaccgtga agctctccgt agagctcgac aatccctctg 2162821 attaccgtcg tttttcctgt tcccgggccg cctgttaaaa gaagcatcgg cgaggaaagg 2162881 gctttttgaa tcgcttcctt ctggctgggg gcatactgaa cgtccatccg ttcttccagt 2162941 tctcccaacg cgagcaaaaa ctctgattcg ggaaactggt tctcatattc ggtttggcta 2163001 gcgatatgtt tcacacgctt tgcaacgttt tgttctgcgt aaaacagcga aggaaaataa 2163061 cagcggccat cttctatgac aatgtcttta ttttctccaa gggcaataat tgcgttagcg 2163121 gcatccattt ctgtaatgcg ctgcccttcc cttgctgact ggtttaacag tgattgagtg 2163181 tcgatgatca gctgttccgt ttctatgtac gtgtgcccct ctgacagaca agtcgtttca 2163241 agcgtgtaca aaatagcagc ttttacccgc tcaggatgat tacccgaaag acccattctg 2163301 ctgcccagct catccgcttt tccaaacccg atgccttcta catccttcac aagctgataa 2163361 ggattttcct gaatcttttc aagcgtctcg gattcatagg cttgatagat tttcatagac 2163421 agctgcgggc caaagccaaa ctgattcaag gaaatcatga tttgctccag tccctgatgc 2163481 cgctgcaatg cgccagccag cgtgtctgct ttcttttttg agagtctggg aacatcataa 2163541 agcactgaag catcagccaa tattttatta atggcgctgt cgcccagctt tttcacaatt 2163601 tcttcagctg tttttttgcc gatcccctcg aataaatcac tcgataaata ttgaatgatg 2163661 ccttccttag tcgttggaat ctcctttttg aaatgctccg cctgaaattg gagcccgaat 2163721 tttggatggg ttacgatctt tccgtaaaac gtgtaggtct cttcttcttg aagcgcaggg 2163781 aagtagcccg tcacggatac ggctttatct tcaatggctt cggaggtctc tgtgactttc 2163841 actttcagaa ccgtatataa attggtgtca ttatgataga tgactgtgtt gactgtccct 2163901 tttaaatagg gctcttcctc cagtttaagc tgatccggat gctgctgcac gagctgtccc 2163961 tcctcctgtg cctgttatga tggatcaatc agttttttag catgaagcgc aagcatatga 2164021 tctggctgga tatcgattgc cttgtccagc atttccagcg ctttttctcg gttttcttta 2164081 taagcataag tgacaccggc attataaaat gcatctgcat gccccgggtc ttgctctgtc 2164141 acagctgcga attggctgag cgcttcgtcc agcatgccct cgttggctaa gcacatcccg 2164201 aattgaaaac gcgcttccgt atcgttttca ttcagttcga ctgctctttg taaatatggc 2164261 agtgcaagct taggctgttc gagcttgaca agtaccgttc cgagcatgta aaacaggtcg 2164321 ccgttttcca tccccgcacg tagcgctttt tcaaacatgt ctttcgcttc tttgtacatt 2164381 tcttttacaa catagacatt tcctgctcca taataagcag tggctgcgct actgtctaat 2164441 tcaagcgctt tatcataaaa cgcaagcgca cgttccagct cgtttacgga tgaaagaagg 2164501 ttggcaaaat tgatatacgg aatcgcgtct tctttatttt cttcaatcgc ttttgtaaat 2164561 gcctctgccg ctttctcgta atcgccttcc tgcatcgcct ctataccgag ttgattataa 2164621 tccaccgatc atcttccttt cattaaaaaa ccccaactca gtgttgaggt ttttcatctt 2164681 ttatacgtac cacaattttg ttccgtcttt gtacacatca tcaattgtcc cgccgccaag 2164741 gcattcttcg ccgtcataga agacaacggc ttgtcccggc gttacagcgc ggacttgttc 2164801 atcaaagatg acttccgctt caccttcgcc agtcatgcgc actgttactt tatgatcctc 2164861 ttggcggtaa cggaatttag ccgtgcagga aatctcttcg cccttcatga tatccgaacg 2164921 tacccagctg atatttgttg ctgtgatttt gtcggaatat aaaagcgggt tatggaaccc 2164981 ttgatctacg tagaggatgt tcttttcaag atctttgcct accgcaaacc acggctcgcc 2165041 gcttccgccg atgccaaggc cgtgacgctg tccgatcgta tagtacatca acccgtcgtg 2165101 gcggcctttt acttcgccgt ccatcgtcat catatcgccc ggctgtgcag ggagatattg 2165161 gctgagaaac gttttgaagt tgcgttcgcc gataaagcag atgcctgtac tgtctttttt 2165221 cgtcgctgtt gcaagttctg cttctttggc aatttcacgc acacggcttt tttgaagttc 2165281 gccgatcggg aacatgactt tgctcagcgt atcttctgtc agctgattca ggaagtacgt 2165341 ttgatccttg ttttcatcaa tgccgcgcag cattctgact tttccgccgc ttctgtctac 2165401 tcttgcatag tggccagtcg ctaaatagtc ggcgccaagt gacaatgcat gctccaaaaa 2165461 ggccttgaat ttaatttctt tgttgcacaa tacatccggg tttggtgttc tgcctgcttt 2165521 atattcatca aggaagtatt gaaatacctt ctcataatat tgcttttcaa agtttacggc 2165581 ataatacgga attccgattt ggttgcagac gcggatcaca tcttcataat cctctgtcgc 2165641 cgtgcaaaaa ccgttttcgt ccgtatcatc ccagtttttc ataaagattc cgattacatc 2165701 atagccctgt tcttttaaca gcagggccgc cacagatgag tctactccgc cggacatgcc 2165761 gacgacgact cttgtatcct ccggccgttt ttccatttca ttcactccaa ttactacgcc 2165821 gccttattat gtcagccgtt tgacaacgtc ggccacatgt ttggcagcag ttttcacttg 2165881 ctcagccgta ttgccgaggc cgaagctgat tcgaatagag gacgtcagcc ggtcactctc 2165941 ttcgccgaac atagcagtca gaacatgtga cggcaggact gaaccggccg tgcacgctga 2166001 accgctggag acagcgacac cagccatatc aagattaacc agcagcgctt ccactgacac 2166061 accggggaaa taaagattca gaacatgcgg cagactatgc tctttgtccc cgttgacctc 2166121 gaatgccaca cctgcatctc taagcgtgtc ggcaaagatt gctttaaacg attgatactt 2166181 ctcgtttttt tcgtcacgtt cttcacttga cagcttgatc gcttctttca gcccgacaat 2166241 gcctggaaca ttttccgttc cggcacggcg ttttctttct tgctctcctc cgaataaaag 2166301 gggtgaaagc ttcacatctt tactagcata taaaaagcct gtcccttttg gcccgttgag 2166361 cttgtgcccg gaaacagaca gaaggtcaat atggctgttt ttcacatcaa ttggcagcaa 2166421 cccgaatgcc tgaacagcat cggtatgaaa ataagctttg tgttccttta acagctcacc 2166481 gatttcttcg atcggctgca ctgttccgac ttcattattt ccatacatca ctgtcacaag 2166541 gattgtatca tcacgcagtg cttctttcac ctgttttgca ctgactcttc cattttggtc 2166601 aacgtccaga tacgttatgt caaatccgtc tccctcaagt ttttcacatg tgtgaagcac 2166661 ggcgtgatgc tcaatttttg ttgtgatgat atgtctgcca agatcttttc ttgcaagtgc 2166721 ggttcccatg atcgccaagt tatcagcttc cgttcccccg cttgtaaaaa tgatctcctg 2166781 ctctgccgct ccgatttctg ctgcgatctg cgctcttgct tcatccaccc attttcgaga 2166841 ttctctgcca aatgaatgaa tactggaggg attaccgaaa ctgccggaga agtgcggtat 2166901 catttgttcc agcacgcgct catccatcgg agacgttgcg gcatgatcta aataaatccg 2166961 ttccattatg tttacacctc tgatctaaat atagaacata taagcttctt gctctccgtc 2167021 tgtatagctg gcaagatcct ctaatgttgt actgtctaaa acctctttta cagcatcccg 2167081 gatgcgaatc cagagctcac gcttggcagg ctcctcatct tccagcactt caacagggct 2167141 gatcggcccc tcaagcacac ggataatatc tcccgcagta atggcatccg gctcactgcc 2167201 taatacatat ccgccatatg cgcctctgat gcttttcact aaaccggcat ttctgagcgg 2167261 cgataccagc tgctccaaat aatgctcgga caaattattc gtctgtgcga tgctttttaa 2167321 tgaagtcggg ccttcaccgt gcttttttgc aagctcgatc ataatggtga gcccgtatct 2167381 tcccttagtt gatattttca acatgaacac ctctgttatt tcatgatttt ccacatttat 2167441 aatggtaatt tctatatgtt tcgtccgttt attatcttat agaccaactg ttattataac 2167501 ataccttcag cgaattttca ttgaggcaga aggaaagggg cctttaccct tttctaatgt 2167561 acggttttcc gttaccctgt aattaagtaa ggagagatga tagatgaagc cattggcata 2167621 tcggatgcgt ccgacaaaaa tagaggatat tatcggccag cagcatctgg tggctgaaga 2167681 taaaattatt ggcagaatgg tccaggcaaa acatttgtca tccatgattt tgtacgggcc 2167741 gcccggaatt ggaaaaacat caatcgcaac agcaatcgcc ggttcaacaa gtattgcttt 2167801 tcgaaagctg aatgctgtca ttaacaataa aaaagatatg gaaatcgtag ctcaggaagc 2167861 caagatgtcc ggccaagtga ttttgattct ggatgaagtc cacaggctgg ataaaggaaa 2167921 acaggatttt ctattaccct atttagaaaa cggaatgatc attttgatcg gagcaacgac 2167981 ggctaacccg tatcatgcca ttaatccggc gatcagaagc cggacccaga tttttgagct 2168041 tgaaccgtta acacctgaac tgattaaaca ggcactggaa cgtgcgctcc atgatgagca 2168101 tcggggcctt ggcacctatt ctgtatccat tgatgatcag gcgatggagc attttgccca 2168161 cggatgcgga ggagatgtcc gctccgcttt aaatgcgctt gagcttgccg tgttgtcaac 2168221 gaaggagtca gcagacggtg aaattcacat tacattagaa accgcggaag aatgcttgca 2168281 gaaaaaaagc ttttctcacg ataaagatgg tgacgcgcat tatgatgtac tgtccgcttt 2168341 tcaaaaatca atccgcggct ctgatgccaa cgctgctctt cactatttgg ctagattaat 2168401 tgaagccggt gatctggaga gcatcgcaag acgattgctt gttatcgcct atgaggatat 2168461 cggtttagca agcccgcaag ccggccctag agtgctgaac gctattcaga ccgctgagcg 2168521 agtcgggttt cctgaagcgc gaatcccgct ggccaacgca gttattgagc tttgcctctc 2168581 accgaaatca aactctgcca ttctggcaat cgatgaggcc ctggcagata tcagagccgg 2168641 aaaaattggg gatgtcccga agcatttaaa agacgcgcat tataaaggag ctcaggaatt 2168701 aggaagagga atcgactata aatacccgca caattacgac aacggttggg tcgaacaaca 2168761 atacctccct gatcctctga aaaataagca atactataag ccgaaacaga ctggaaagtt 2168821 cgaatctgcc ttaaagcagg tgtacgataa attaatgaaa agaaaataaa acaaaaaaac 2168881 agccttgatc atcaaggctg tttttatgca ttatttatcc ttcacacgtt tgatttcaat 2168941 gtctttcaaa agatccatga caacatgtcc gcccataatc aaacctgcaa ctgacggcac 2169001 aaaagcatta gaggaaggcg gcatttttgc tttacgtatt ttcgcttcgt cattccccac 2169061 ttcttttctg acatcttccc gaataacaat cgggctttca tcagagaaaa tcacttgaac 2169121 gccttttttg ataccctcct tgcgtaattt cgtacgaacg accttcgcaa ttggatcagt 2169181 gtgcgttttt gagatatcag cgatttggaa gcgtgtcgga tccgttttat ttgcagcacc 2169241 catgctggag atgagcggaa tatcccgttt tagacattct ttcattaaat gaattttata 2169301 acaaatggtg tctgacgcat caatgacata gtcaagacca tagtcaaaaa actgctcata 2169361 cgtttcctcc gtatagaaca tttttaacgc gatcacttca cactccgggt taatgtctgc 2169421 gatccgcgcc ttcattaaat caactttcgg ctgtccgaca gttgaaagca gcgcgtgaag 2169481 ctgacgattt acatttgtaa tgtcgacatc atctttgtcg acaagcagaa tgcggccgac 2169541 gcctgaccgc gcgagagctt ccgccgcgaa cgacccgact cccccgactc caagcacagc 2169601 aactgtgctg tttttcagcg tttcaaggcc ttcttttccg atagctaatt cattgcgtga 2169661 aaactggtgt aacaagaacc tcactccaca ttcgtattct ggtttcatct ataaaatggc 2169721 tgatccatga gcagccgttt tttctgcgca caaaaaataa agtcccaata gtgccgttgc 2169781 agctttcctt tgttttgaac ccgctctcag caggtgggtg ccctctttta aatcttgtaa 2169841 gtcctcttta ccgaatgaaa agaggcatgt acgccattta aaaatgcggg ctcccaaatc 2169901 aaaaaaatgt tcggtcaaaa ctaggtgtac aactaacaca tcaggacttt atttaacttg 2169961 tcaaaatcat atcacagacg attttgattt tcaagaatcg aactgcaaat tcagttctta 2170021 acttttttct tgatagaaag atgaagctcg tcaagctggg cgtcgcttac ttcgcctggc 2170081 gcttctgtca tcaggcagct tgcacttgcc gttttcggga atgcaatcgt atctctcagg 2170141 ttcgtacgtc cagcgagaag cataacgaga cggtctaagc cgagtgcgat tccgccgtgc 2170201 ggaggagcgc cgtattcaaa tgcttccagc aggaatccga actgttcagc cgcttcttct 2170261 ggtgagaagc cgagaagcgc aaacattttt tcctgaatat ccttttcgaa aatacggatt 2170321 gaaccgccgc caagctcata gccgtttaag acgaggtcat aagcttgcgc tttcatgtct 2170381 tcaggcgctg tttcaatcag ctcaaggtct tctcggacag gcattgtgaa cggatggtgc 2170441 gctgcgtaaa aacggccttc ttccggatca tgctctaata gcggccagtc gatgacccat 2170501 aagaaattga acaatttttc gtcaatcagt ccgcgttctt tcccaagctt taagcgcagg 2170561 gcgccgagtg atgcggccac aacttcgaat tgatccgctc cgaacagcag caaatcacct 2170621 tcagcagcat caagtgcttc aatcagctta gactgctttt cttcatcaaa gaatttagcg 2170681 atcgggcctt tcactccgtc tgcctcaacc ttcacccagg caagcccttt tgccccgtag 2170741 tttgcagcaa aagcgccaag agcgtcgatg tcttttctgg agtaatcgcc ggcaccgcct 2170801 tttacattga tggctttgac cacgccgccg tttgctacag ctgatgagaa cactttaaat 2170861 tccgtatcct ttacaatgtc agacacatcc gtcaaaagca tgtcaaaacg cgtatccggt 2170921 ttatcagacc cgtacttgtt cattgcttcg tcatacgtca ttcgaggaag aggaagctga 2170981 agttcctcac cttttgtttc acgcataacc tttgccatca tctcctcagc caatgacata 2171041 atgtcttcct ggctcataaa ggacatttca atatcaattt gcgtaaactc aggctgacgg 2171101 tccgcacgca agtcttcatc gcggaaacag cgggcaattt gataatatcg ttcaatgcct 2171161 gataccatca gaagctgttt aaatagctgc ggagactgcg gcagcgcgta gaactcacct 2171221 tcgtgcacac ggctcggcac caagtagtca cgtgcgcctt caggcgtgct tcctgttaaa 2171281 atcggcgttt caatatcaag aaacccattt tcatctaaaa agctgcgaac agctttcgtc 2171341 acgttatggc gcagctgcat cgtctggaac atagccggtc tgcgcaaatc taagtaacgg 2171401 tgttttaaac gaacgtcctc tgacacttct tcagcttgat cagaaatcgc aaatggaggt 2171461 gtctttgcag catttaatac gttcactcca tcagcatgta tttcgatcgc gcctgttttc 2171521 aaattcggat taactgttcc ctcttcacgc gccaccactt ttccttgaat atcaagcacg 2171581 tattcatttc tgatgccttc cgcaatagca agcgcttctt ttgacacatc agggttaaaa 2171641 acgacttgaa caatgcccgt acggtcacgc aagtcaataa aaatcaatcc gccgaggtct 2171701 cgtctttttt ggacccagcc tttcagcgtt acagattcgc caattgcttt ttcagttata 2171761 tcaccgcaat aatatgttct tccaaacaat gcgtttcact ccttatccct tttggtttgc 2171821 cttcatcaca tgtataaatt catcaagtgc cacttcaatc tgttcgcccg tctgtgcatc 2171881 ctttacattg attttgtttt gggcaagctc atcttcaccc aaaatcgcaa taaatctggc 2171941 ctttaagcga tcagctgttt taaactggcc tttcattttc ttattttcat aatcgatttc 2172001 actggaaatg cctgcttctc tcagtttgta caccaatgaa acagaataat cctttgcttt 2172061 ttcgccgagt gtgacgatat agcagtcgat tcccttatca acaggcagct ctcttttttc 2172121 agcatcaatt gcggcaagca agcgttcgat gctcatcgca aatccgatgc ccggtgcttc 2172181 aggtccgccg atctgttcga caagcccgtc gtagcgtccg ccgccggcaa gtgtcgtaat 2172241 cgcgccaaag ccctccgcat tgctcataat ttcaaatgcg gtgtggttgt aataatccag 2172301 ccctctcaca aggttcggat cgatttcata cgaaatgcca agatcattta agtattgttt 2172361 cactttttca aaataagcgg ctgattcttc atttaaatat gtcaaaatcg aaggtgccga 2172421 tttcatcagc tcatgatcac ggtctttttt gcagtccaaa attctaagcg ggttcgtgtg 2172481 cagccgggac tggcagtctg aacaaaattc ttcgatgcga ggctcgaagt gtttcacgag 2172541 cgcttctctg tagcttttgc ggctatcttg atcgccgaga ctgtttatga caagcttaac 2172601 gttttctaaa cctgcttttt cataaatact catcgcaagc gccattactt cagcgtcgat 2172661 tgcagggtct ttcgaaccaa tcgcttcaat tccaaactga taaaactggc ggtaacggcc 2172721 cgtctgagga cgttcataac ggaacatcgg cccgacataa taaagctttg tcggctgtac 2172781 aggatttgcg aacagcttgt tttcattaaa agcgcgaacc gcagcagctg ttccctccgg 2172841 acgaagcgtc aggcttctgc ctttgcggtc ctcgaaggta tacatttctt tttgtacgat 2172901 atccgttgat tctccgacgc ctctggcaaa cagttctgta tgctcaaaaa tcggtgtgcg 2172961 gatttcttta tattgataag tgcggcaagt gtctctcata atttgttcaa caaactgcca 2173021 gcgatctgat tctccaggca gaatatcctg tgttcctctc ggaatgttat atcccatagg 2173081 tagacctcct tatgtattcc ttataaaata tccaatgatc gttaatgatg aaaatgaaaa 2173141 aaactcccgc ccctactata catgatagta gggacgagag ttatacccgt ggtgccaccc 2173201 tagttggaat acgttcatat tcccgctcga tcctttaacg caggttcacg ttcactgcct 2173261 aatggcgtta ttcacgcgtt cagcaggaaa cctccggagt gttgtttcga gaaagacgca 2173321 atgggatccg ctttcagcct ggggcgggtt cctctctaat catgcaatct gacctactct 2173381 tctccattat tggttcaaat ctttcatcat ttgctatgta ctcaatttct attataataa 2173441 tgggattggg gttctctgtc aagctttatt ccggttgttt ttcctcagcg ctgcttcttt 2173501 ggacataaga ccaaattcag atgctgtttc cgtaagataa ccagtcgtat cgggatctgc 2173561 gtgatcgctg taatgcagat tcgcttcacc gtcgtgaaat gcacgtccca tttttggatg 2173621 atatttcatg atttgcacac ctttttgatt gtatttacgc ttagtataaa caaatcattt 2173681 tatttttatt taaaaatcag aaaggacttt acgatattaa acaagaatgc ttttttaatg 2173741 atcatcagaa aggaggacac aatgaacaag aaatactttg tccttattgt atgtattatt 2173801 ttcacctcag cgctattccc gaccttttca tccgttacag ctgctcaagg agaagcggtc 2173861 atcgcaacag atgaaatgaa cgtcagaagc ggcccagggc ttagctacgg cattacagcg 2173921 gaagtaaaaa agggagaacg ctatccaatt ttaaaggaag atggagactg ggtgcagata 2173981 cagcttggtt ctggagaaaa gggctgggta gtctcctggc ttattacaaa ggaagaccag 2174041 gccagcacaa gctcctcagg aagcagtgac actgtgacat caacagaccc cgatctgcgg 2174101 atgagaagcg gcccgggcac ttcctacgaa gtcatcggca aattcccgca aggcagccaa 2174161 gcatctgtca ttgataaaga ttcgggctgg atcaagatat cctatcacag tgccaccgga 2174221 tgggtatcat ctgaatatgt cacatcagga ggcagcagtt cagcgtctga tgagagtgac 2174281 caaaccgagg attccggtgc gtcaacgacg ggcacagtcg gtgtttcttc gctaaatgta 2174341 agagcctccg cctcacatga cgcggcaatt ataacaaaac ttgatcgcgg aacgaaactg 2174401 acggttctca acgagaaaaa tggctgggct cacattgagg tgaacgggct aaaaggctgg 2174461 gttgcaagcc attacctttt gactagttct gttccagctg atgattcagc aaatgccggc 2174521 agttcatcct ccgctaaaaa agcctatatc atgtacggag gaacgaatct aagaagtgat 2174581 gcgtcaacat cagcttcgat cgttgagcgc gctgccaaag gagattcata caccattacc 2174641 ggttcaaagg gaagctggta tgaaataaag cttgataacg ggcagactgc ttatgtagcc 2174701 aattgggtgg tccaaacgtc taaaagcgca gaagaagcag gtgaaccgcc agtctctgat 2174761 tccccgtctg gaaacggctc tctaaacaat aaaacgatta ttgttgaccc gggacatgga 2174821 ggaaaagaca gcggaacgat cgggtattcg gggaaattcg agaaaaacct gacgatcaaa 2174881 acggcaaaac tgctcgccag caaacttaga tcggctggag cggatgtata tgtgacacgc 2174941 caggatgata cctttgtcag cctgcagtca cgggtctcta cctctcacta ccgtaacgct 2175001 gacgccttta tcagcattca ttatgacagc tatgcggata cctctacaag aggcagtaca 2175061 gcatattact acagtcctgc caaagatcag gaactcgcat cagatgtcca ctcagaagtg 2175121 gtgaagcgtt cttccattcc agaccgcggc gtattattcg gagattatta tgtgctccgg 2175181 gaaaacagac agcccgctat gctgtacgag ctgggatatg taagccatcc gcaggaagaa 2175241 gccattgtac atagcaattc ataccaagaa aaagtaacag atgggatcga aagcggatta 2175301 gagaaatact tccaataaaa aaagctgcct tttggcagct ttttttattt tgaatccata 2175361 atgagcgtga ccggtccgga gtttgtaagc tgaacatcca tcattgctcc aaacgttccg 2175421 gtctccactt tgattccttt ttcacgaagc aggtcattcc atttttcata aagacctaaa 2175481 gctttatcag gtttggccgc gttcatgtag ttcggccggc gccctttttt cgtatctcca 2175541 taaagcgtaa actgtgagac ggataaaatc tctcctccta tatctacaag agacagattc 2175601 attttccctt cactgtcatc gaaaatacgg agattgacaa ctttatcggc taaataagct 2175661 gcatcatctt ctgtatcatc gtgagtgatg ccgaccagca ccataaggcc ttgtccaatt 2175721 tggccgacga cctcttcgtc cactgtaacg cttgcttctg ttactcgctg aacaactaat 2175781 ctcttttcta acccctttag ttcatgacgc ggcgcacaga atagatatct ctaatctgtt 2175841 taatacgctc gacgacttta tgcaagtgat tgatattctg gataaaaatc gccatatgga 2175901 tggttgccac tttattgcga tccgatttgc cagagacaga tgaaatattg gttttcgttt 2175961 cattcactgc ctggagtacc tcgttcagca atccgcggcg gtcataccca agaatctcta 2176021 tctcaacatt gtattccttg cgcttttgaa cttgtgactc atgttcccac tctaccggga 2176081 tcagccgctc ttgggcttca ttcgttttga cattcggaca gtcttcgcga tggaccgaaa 2176141 cccctctgcc ttttgtgata aagccgacaa tatcatcacc tggcacagga ttgcagcatt 2176201 ttgataaacg gacaaggagg ttgtcaatgc ccttgacacg aacgccagct tcccgttttc 2176261 ttccttgcgg gtatggctta ggttccccag tgacttcctg aacgatcttt tcctgttctt 2176321 cctggtcgcg ctgctttctc tctttttctg ttaggcggtt cgccacctgc agagctgtga 2176381 tgccgttgta accgaccgcc gcgtacatat cctcttcatt tgagaaatta aatttgtcag 2176441 caaccttttg aatattctcc ggcgttaaaa catccttcaa ttcaaaatcc aagtttttaa 2176501 tttctttttc gaccagctca cggccttttt cgacattttc ttcacgccgc tgtttcttaa 2176561 agaattgacg gattttatgc ttcgcttggg atgtttgggc aagcttcacc caatcctggc 2176621 tcggaccgta ggaatgctta gaggtgagaa tttcaacgat atcacctgtc cgaagcttat 2176681 ggtcaagcgt aaccattttt ccgtttactt tggcaccgat tgttttattg ccgatttcag 2176741 agtgaatccg gtaagaaaag tcaatcggaa cagaaccgga cggaagctcg attacatctc 2176801 cttttggcgt aaagacatac accatgtcag agaacaaatc aattttgagc gattccataa 2176861 attcttctgc atctgtcgat tcattttgaa attctaaaat ttcacggaac caagaaagct 2176921 ttttctcaaa ggttgcacct tcattggctg ctttcccttc tttataagcc cagtgagccg 2176981 caaccccgta ttccgctatt tcatgcattt caaaggtgcg gatctgcact tcaagcggat 2177041 cgcctttagg cccaataacc gttgtatgaa gcgattgata catattcggc ttcggcattg 2177101 cgatataatc tttgaatctg cctggcatcg gtttccagca tgtgtgaatg atgccaagca 2177161 ccgcgtagca gtcctttatg ctattcacaa gaatacggac agccaacaaa tcgtaaattt 2177221 cattgaattg cttattttgc agcaccattt ttcgataaat gctgtaaata tgtttcgggc 2177281 gtcccgagaa gtcagccttg atatttactt cttcgacacg tttcttcact tcattgacaa 2177341 cctcatcgac ataaagctct cgttctgcac gtttcttctt catgaggttg acaattctgt 2177401 aatattgctg agggttcaaa taacggagcg ccgtatcttc caattcccac ttaatttttg 2177461 aaatcccgag acgatgcgcc aaaggagcaa aaatttccag cgtttcattg gagattctcc 2177521 gctgtttttc ctgaggcaga tgtttcagtg tccgcatatt gtgaagacga tccgccagct 2177581 tgatcaatat gaccctgata tcttgagcca tagcgacaaa cattttgcga tgattttccg 2177641 cctgctgttc ctcttgagat ttatatttaa ttttgccgag tttcgttacg ccgtctacaa 2177701 gcattgccac ttcttcggaa aatgcttctt tcaggtcatc gagcgtcaca tctgtatctt 2177761 ccacgacatc gtgcaaaaat ccgcccgcga ttgtggaagg gtccatttca agatcaacga 2177821 gtatccccgc aacctgaatc ggatgaataa tatatggctc gcccgatttg cggtattgct 2177881 cgcgatgagc atcttcagcg tacagatatg ctttttcgac aaatgcgata tgctcatcag 2177941 atagatagct gcgtgcttta tctataactt gctcggcagt caatacttgt tcgttcgcca 2178001 tggaatcacc ttttttaaaa tgtaaactgt attgtagttt attatcaaga aaaaaacgaa 2178061 agatgtaaag agcagaagtt caaatagcca aatattatat aaaataaatg caaaacaata 2178121 ggaaaaaagc accctgacat ggagtgcttt ttcgttatgc ggttatcctt agtatttcat 2178181 caatgttaag atgtcgtaat cttcgagctt atttctgccg tcaaggtaag aaagctcgat 2178241 taagaaagcg ataccagcaa caacgccgcc aagttcttca acaagtttga ttgtcgcttc 2178301 aattgtgccg cctgtcgcaa gcaggtcatc tgtaataagc acacgctgac caggcttaat 2178361 cgcatctttg tggatcgtta atacgtcttt tccgtattcc aagccataat ccactttgat 2178421 tacttcacga ggcaacttgc cttctttgcg gaccggcgca aaacctacgc caagcgcgta 2178481 agcaacggga cagccgataa taaagccgcg cgcttcaggg ccaacgacca aatcaatttg 2178541 cttttctttc gcatattcaa caatttgatc tgtggcatag cggtatacat cgcctttatc 2178601 catcagtgtc gtaatatctt taaattgcac gccctctttc gggtaatccg gtacaattgt 2178661 tacgtattgt tttaaatcca tctgttttat gtcctcctcg tactttcata agcctctgaa 2178721 tcttgtttca tcagcttatt cagccattcc ttcagctctt cagcagaaga ataattcagc 2178781 ttttgatcca gttccatcag ctgctgtttc gcctgatatg tttgtgagtc tgttaagtcg 2178841 cgtttctttg ctccgctcac aacagacagc acaccattct ctattttaac aaaaccgaga 2178901 tcaaaaaaca cctttgtcat gaaattgatt gtttcaacgg accagccttt atgttttgca 2178961 agctctgaac cgtgtttttt cacgtcaaaa gcgcctcttt tcagcaagaa cgcataatac 2179021 catttaaagt ggtctcttgc gggaaaagtt gataaaaagt ggtcctcatg attgagaaaa 2179081 ataaaatata tccgctcggg cgcctttcct tccagcaaac gtgcgagcat gtccagcgaa 2179141 ggcggcggat ccagtaatac aatatatgca ccatcgaggt caaacgcctt tgcttgatct 2179201 ttagaactga tgacgtgcac ttctcggcga aggtcttcag tttgaagtaa tgttgttgag 2179261 tcttctttga aagagacaat ggcccgttta gcagatggaa gggcggaaac tgtgtcttcc 2179321 cacgtccgtt ttccccttaa atcaaacagc tgccattcag aaacagcggc atcctttatc 2179381 ataagctgcg gcttttttcg attgttccat tcgttgattg acatctcacc gacaatggaa 2179441 attcttgaac ccggtacgat gccttcttga agctcgcctt tattaaaacc gacgcaatca 2179501 agctgggacg actcgtttct gatcgtcatt ttgacatgag ttttatttgc ccctatcttg 2179561 cggacatctt ccagtactgc attttctacg agaacgtgcg gtttcgggtt cagcatgcca 2179621 aaaggagaca gcatgttcat ttctgcgatg ctttcaactg taatgtcttc gacgccgcag 2179681 acaaggtcga cttcctgtac gggaataaaa tcctcttccg taagcgtatt gtccgctatt 2179741 tcattcagcc tgcttcgcaa atccggcaca tcttcggctt tcagcgtcat ccccgcagcc 2179801 attggatggc cgccgaaatg aggaagaata tctctgcatt cagaaaggct ctcaaataaa 2179861 ttaaatcctc tgatgcttcg ggccgaacct ttagcgattc ccttttcttc atcaatacca 2179921 agaacaatgg ccggtcggta gaaacggtcc acaagctttg aagccacaat cccgacgact 2179981 cccgggttcc atccggcttt ggccacgaca attgcagttt gatcgagccc ttgctgttca 2180041 accatttcaa tcgcttcatc cgtcattttg ctgaccattt tttggcgctc tttgttcagc 2180101 tggtcaattt ctgcggcaag ctcttccgct tcaaacgaat cctctgacat aagcaaatga 2180161 acagcgggat ccgcctgttc gattcttccg acggcattca gccttggtgc gagctgaaat 2180221 ccgactgttt cttcgttcgc ttctccgatg tctccgcctg acagcttaat cagctctttt 2180281 aagccgagcc gatttgtccg tcgaagcctt tcaagtccta gtgttgctat taatctgttt 2180341 tcgtcatgca gcgggactag atcggcaatg gtgccgatag ccgccaggtc aagcagttca 2180401 tcaggaagtt cacccaataa agcgtgggca agcttaaacg cgactccaac cccggcaagc 2180461 tctttaaacg ggtaagtgca gccaggctgc ttcgggtgga cgatcgcacg gacatccgga 2180521 agctccggtc ccggttcatg atgatcggta atgatgacat ccagtccgag ttcctttgcc 2180581 accttcgctt catgcacagc ggcaattcct gtatcaaccg taatgatcaa agagaagccc 2180641 cgttctttaa tcgaacgaaa cgcctgttca ttaggtccat atccttcttt aaaacggtca 2180701 ggtatataaa aatcaacttg agccgacagt ttttgcagcg tgtgaagcat cactgacgta 2180761 cttgtaaccc catcggcgtc ataatcgcca tatatcataa tcttttcttg ttgtgaaatc 2180821 gcctgtttta ttcgatctgc cgcttctttc atgcctttca tttcaaaagg atcataaaaa 2180881 tcggcatcct ttgtatgtaa aaacagccta gcgctttctg ccgtatcaaa gcctcttttt 2180941 acaagcaggg acgcaacaag aggtgttata tgcaattgtt ctgtgagtga tttgacctta 2181001 tcctgatctg gtcgctggat ttcccatcgc atttttgacg ctaacataaa ttcacccctc 2181061 aaccacccta ttatactaga gcaggctgag gggtttcaaa taatattcga aaactagtct 2181121 tttttctcaa tcatggctga tgcatcctgt gtgtcagtct gatcagcaag atgagtatcc 2181181 tcttgtttat gtattgctgt tctattttct ttccgcaagg tttttatttc ccgcttcaat 2181241 ttcattacct gaaaaatgcc gacagaaaat acgatcagtg ctcccattaa aactgagccc 2181301 aaaataacaa gaatgagcgg ccattctgat cttccaaaca ggtaatcaac ttctacggat 2181361 cgaacattaa tgactgcgaa aatagcgaca attaaggtga aaataagtgc gaaaataatg 2181421 gtccattgtt tattcattct cttttccccc aaacttctta ttgaggtaac tttcccaatc 2181481 aagactggtt ttaaacatgg cttaacacta ggttaagctc cctttgctgt taatttttcc 2181541 cggatcagcc tcttcagtcc ggttccctca ccggaaatca caagtgtatc gccttcgtca 2181601 atgactgttt cagagctcgg attcagttgt ttatcctgat tctttttaac aattgcaatg 2181661 accgtcacat gatattcctg acccacattc aaatcaccaa tcgtctgatg aatggcaggc 2181721 gctcccgcct ctgctttaca ccactctata atcaaatcat caagggctga ctcgacctgt 2181781 tctaatgctt tcggtttata tgccattccg ccaagaattg cagacatttg ccttgcttca 2181841 gcgtcatcaa actgcacgga ggcaacacat tcctcatggt cgttttcgtc aaaatagtaa 2181901 agctctctcc gtccgtcatg atgaatgata attgaaattt tatcacggtt tctagtaatc 2181961 atttcaactt tttgtcctat gcccggcagc tctgattcgc gaaccctcat atataaaccc 2182021 tcctacatat ctgaaaacca gccataaaca cttttaacac catatatatg tttaaatgta 2182081 agcgtatgtc attatagcaa atgtctattt taagttcaat gaaacttcaa aaaacaggct 2182141 gccctgcaga ggacagcctg atatttttta ttgcgccgaa tcttttttca gttctcttcc 2182201 tttccatgca agccaaattt gtgcggcaat gtatagagaa gaataaacgc ctgttaacag 2182261 cccgaccaat aaagcaattg agaagttagt aatagaagat gctccaaaga tcagcaatgt 2182321 cacaacaaca atcacaacgg ttaatacagt gttaattgaa cgtgtaaagg tttgctgcag 2182381 gctcaggttt acaatatggt tcagatcggc aaaggttttc ggcttacgct ttttcatatg 2182441 ctcgcggacc ctgtcaaatg taacgattgt atcgttaatg gaatacccga ttatcgtcaa 2182501 gatggccgcg atgaatgtaa catctacctc aagccttgta atactgaaga acgtgacgat 2182561 aaagaatgcg tcatatagca atgaggcgat ggcagcaatc gccattttgt attcgaatcg 2182621 gattgaaacg taaataatga tgccaataga agctatagca actgcgtaca gcgcatttct 2182681 cgccagctcc ttaccgactg tcggtgaaac tgtgctgaca tttggatcag atccgtattt 2182741 gtctttaaaa tacgttttta cttttgcaat ggtttcttta tctggcaccc cgacaaaacg 2182801 ggcaacaccg atattgctct tttcgcctga cagaactaca gtatcagggt ccatacccag 2182861 agattcaaaa tccttctcaa cttgctctgt cgtcagctta tggtcgcttt gcacttcaat 2182921 ccgtgcaccg cttgcaaagt caatgccaag attcagcctg aacacaagca ggataataat 2182981 cccggcaacc gtgaccgcac tggagaaaat aaagaagtat ttgcgtttgc tcgtgaaatc 2183041 ccatttttgg aatggcgtat gcggctctgt attttcatcc gtatcctgaa tatccatgat 2183101 atgtttctta ttgacaccaa accagccttt tttccgatca agccatctgc tttccacaag 2183161 gagagcgagg agaaatctcg ataagaaaac ggcagtgata aagcttgtca aaatcgatag 2183221 gatcagcatt gtcgcaaacc ctttaacaga gcttgtccca aagataaaga gcacaaccgc 2183281 tgcaataatg gttgtaatat tcgcgtcaaa aatcgtcgca aatgaccgtc tgtttcctga 2183341 acggaaggca gagcggactg actttcctag cttgagctct tctttaatcc gctcataggt 2183401 aataatgttg gcgtcaacag ccatcccgac acctaaaatg agagcggcaa ttcccggaag 2183461 cgtgagtacg gcattcatcc agtcaaagat ctggagtgta atgtagatat aaacagacag 2183521 cgtaatcacc gcgattaatc ccggcagacg gtaatagaaa agcataaata agaaaataat 2183581 tgcgataccg acaataccgg caaacaccgt atcatggaga gcctgctggc cgaattgcgc 2183641 gcctactgat gtcgaatact tttcagtcag tttcacagga agtgcgcctg cgtttaaaat 2183701 gctggctaaa tctttcgctt cttgagctgt gaaatgacct tcaattttta catcagttgt 2183761 atttagttcc tgacttacat ttggagcgga tacaaattta ggatgctctt tttgaacttc 2183821 tttcttaaag gaatcacctt tatcataatc caaccaaatg acaagctggt tgtttggcgc 2183881 cattttcatg accttcttgg tcacttcacc aaatttatca gcgtctttca gcttaatcgt 2183941 gacaattggc tcatttgttg tgctatcata agtttgttta gcgccgtttt cgactagatc 2184001 agcaccgttt aacagttcct tatcatttgc atctctgaaa gaaagctgcg cttcagtcgc 2184061 caaaatttca cgcgctctgt tttggtttgt cacgccagcg agctgaacgc gaatccggtt 2184121 attcccttca atttggatgt tcggttcgct gacaccgaga acattggccc ggcggttcag 2184181 tgcctctact gtgctgacca gaacgtcttt tgtgattttg tcaccttttt ttacaggctg 2184241 tacatcatac agcacctcaa atccgccttg caaatccaat cctaacgtaa tattgttagc 2184301 ggcaggcttc gtaaagtagc ccaagcccgt gccgatcaat agaacgaaaa ggaaaaacgc 2184361 aatcaagcgt ccttttttca ttatgtatat cctcccttaa acctgtgcga atcaacctgc 2184421 tatctcagca gttcttccaa tgcttcctgg ccctcttcac tgcccagcca attagacgtt 2184481 ttaaatgact caacggttgc atagttcata aattcgccaa ttttcactga taaaatatca 2184541 ctcgccagtt cataaatgct cagttccgtt ttctttttcc acttcttatc tgttaagtat 2184601 gaccacaaac tttcgagttc aacatcatca tacccgagaa tcttaaactc ttccagtttg 2184661 ctgtaaagaa acggcctgac gtggtcttta tatagatcgg ctggatgctt ctccacgaat 2184721 tccacgctcc ttttttattg tttttcaaga agacttgtca tgcttggacg acatatacgc 2184781 atatctttat tgtatatgat tccaggtagt ttgagaaggc agggggtaaa aatggcgaaa 2184841 cagacgtttt taaagggcac tcttatcctt atcgcagcag gaatggttac aagaatgctc 2184901 gggtttgtca accgggtggt tatcgcccgt tttatcggtg aagaaggagt cgggctttac 2184961 atgatggcag cgcctacttt cttcttggcc actacattaa ctcaattcgg tctgccggtc 2185021 gcgatcagca agctagtcgc tgaagccagt gcgcgcggag atcatcaaaa aacgaaaaat 2185081 attttagtca tgtctctgac cattacggga gtgctcagcc tcatctttac accgctgttt 2185141 ctgtttttcg cccctgttat ggctgaaacg atgctgacag ataagcgaac actgtatccg 2185201 ctcttggcca ttacgcctgt tgtgccgatt attgctatat cgagtgtgct gaggggatac 2185261 tttcaaggaa aacagaatat gaacccgctt gctatgtcac aagtccttga acaggttgtc 2185321 cgcatttcac tcgtggctgt ctgcacaacg atttttctcc cttacggaat tgaatatgct 2185381 gcagcggggg caatgctatc ctcagtggca ggggagctgg catcacttct ttatttattc 2185441 gtttgcttta agtataaaaa gacaattaaa atcagaaagc attttttaca gtcaattaaa 2185501 aacggaaaac aaacctttac ccaattaatg agcgtgtccc ttccaacaac cgggagccgc 2185561 tttatcggaa acctctcttg gtttttcgag ccaatcgtcg tcgctcaaag ccttgccatc 2185621 gccggtgtgg caacagttgc cgcaacaaag caatacgggg aactaaccgg ctttgccatg 2185681 acgctgctga ctctgcccag ctttattaca tattctttgt cgaccgcgct tgttcctgcg 2185741 atcagtgaag gaatggagca gaaaaaattg caggtggtgg aataccgctt agaacaggcg 2185801 atgcgtctct gtctgctcag cggaggcatt tcagttgtta ttttatttgt atttgcggat 2185861 gagctgatga gagtgatgta cggttcctca ggcgcagctg tatttataaa agtgatggcc 2185921 ccgttttttc tgctttatta tttccaaggc ccgcttcaag ctgtgctgca ggcgcttaat 2185981 ttggcaggag ctgcgatgat gaacagctta atcggagcgc ttgtcaaaac aggccttatt 2186041 tttgtccttg ccacaaggcc ttctcttggc attatgggcg cggcattagc cattgtgaca 2186101 ggcatggtgc tcgtcacgct attgcacgca gcaaccgtaa gcaaagtgct gccgatcagc 2186161 atcaaaatca aggagtacgc gctcagcttc gctgttattg taatttgcgg attcatcagc 2186221 tccgccatca aacaatatat aagctttgga gcatctgagg ctgtcaatct agccggatgg 2186281 attgcggcga gcgccgccat ttatatgatc ctcctgctcg ttttccgttt aattaaaaaa 2186341 gatgagcttc gccgcattcc cattatcgga cggttgatca tccgataatg gtcacgtgcg 2186401 gtgcccatct ttttcatcaa tatatatttc tccgtctgta aacgagcaaa atgaaatatc 2186461 tgaagggttt gtgtatccgt gtttttgcaa actttcaagc agccattttc tatctttact 2186521 gattctggac aggttttctg tttgaatgaa gccgtctata atgagcggca tttcgagctg 2186581 ccgatgctct ccgctgtttt ctttcttaac aatagtcagt ttgcccgacg gctctaaaat 2186641 agcaaatgat acgtcagcta ctctgtcgat gctattttct ctgagctgaa ccattaaatc 2186701 atcaaaatta taacgctgtg atttcatggc ttcttcgtca atttttccat atttgataat 2186761 tatggtcggc ttaccgtcaa gaagctggcg gacttttcgg ttttttaaag aaaagtatgc 2186821 caaagtcact tgaatgatca ttaatacaag cattggcaaa atggtatgaa atagatgatc 2186881 gtctacgttt tctatggcta aaacggcaat ttcagccatc atgataaaga caacgagatc 2186941 taaaatacta agctctccga tctcccgttt gcccatgaaa cgaaaaatga ccaatatcac 2187001 aaaatacaat acgactgtgc gaaacgcaat agtgagaagc tcttccatta tgcacctcca 2187061 actcattata ggttgcaaca aaatgatcaa tttatgtaag aaaaaccgat tgcatttcac 2187121 aaagctttta cgtctaattc atgggataag ggaatacatt tttacaaaga cgagccatca 2187181 gcatgtctga cggttttgaa caaaaagaac agaagccttt taatacaggc agagaggaga 2187241 caatcatgga ggaaacgaaa caagttggaa aaggcattct ttacggctta atcgccatat 2187301 tttcagccat gctcctgaca agtttagcgg tttcactttt attgaccgca acctcgctgg 2187361 aagaatcatc atttaactgg ctgatcaccg ctatctcatt tctctcttta tttatcggcg 2187421 ggttcatttc aggcgggaaa ggcaaggaaa gaggctggat gattggcgca ttgaccgcct 2187481 taagtttttc tctgattatc ttattgtttc agtatttagg attcggaaag acatttacag 2187541 cagaacagct gatcttccat ctgggatttt taggggtgtg catgctgggc gggattttcg 2187601 gcgtgaacat gaggggaaac aggtcttcca cataaaaaag agcgggctca cttgcccgct 2187661 cttttttgtt tgctatgtat agctcctgct gttattcagc agcagaaact tctctgatcg 2187721 cgcggcggtc gaacgtaaga cgtgtgttat caccagtctt aattacgact ttgctttcgt 2187781 cgatagagtc aacagtaccg tgcaatcccc cgattgtcac tactgaatcg ccttttttca 2187841 gttcctcttg catttggcgt acagcctttt gctgcttttg ctgaggacga atcagcaaga 2187901 agtaaaggac cgcaaacatt aaaataatag gaaccaatgt acctaaagtg ccagtcatca 2187961 ttttcacccc tttctgtaag cctgttatgt ttatttagaa gcttttcgca tttggcttgt 2188021 tatagccgta acgctcaaag aactcttctc tgaaatcacc cagacgatcc tcgcgaatag 2188081 cctgtcttac ctgctccatt aagtgtaaca gaaaatgaag gttatggtaa gttgttaatc 2188141 gaaggccgaa tgtttcattg cagcgaatca agtgcctaat gtacgcgcga gtgtagtttt 2188201 tacatgtata gcaatcacac tcttcatcaa tcggacggaa gtctctttca aatttcgcat 2188261 ttttcatatt gagtcgtcct tcagcagtaa acactgtgcc gtttcttgca atccgtgtag 2188321 gcagcacaca gtcaaacata tcgaccccgc ggatcgctcc gtcgatcagt gcgtccggag 2188381 aacctactcc catcagatat ctcggtttat ccttcggcaa gagcggtgtt gtgaattcga 2188441 gtacacggtt catgacatcc ttcggttcac ctacagacaa tccgcctata gcatatcccg 2188501 gaaaatcaag cgaaatcaag tccttcgcac tttgtgtccg cagatcttca tattctccgc 2188561 cttgtacaat accaaacagc ccttgttcat cctgacgatt gtgggcattc aggcagcgtt 2188621 ccgcccagcg gcttgtccgt tcaactgacc tcttcatgta gtcgtactcc gccgggtatg 2188681 gcgggcattc gtcaaacgcc atcataatat cagagccgag tgcgttttgg atctccatcg 2188741 ctttttccgg agataaaaac agcttgtctc catttagatg attgcggaaa tggacaccct 2188801 cttcctctat attacgaaac ttgcttaaag aaaagacctg aaaaccgcct gaatctgtta 2188861 aaattgcgcg gtcccagttc ataaatttat ggagcccgcc cgcttctttg acaatgtctt 2188921 ggcccggacg aagccataga tgataagtgt tgctcaaaat gatgcctgca tccattgctt 2188981 tcagctcttc aggcgacatt gttttgactg tcgccagtgt gccgaccggc ataaaaaccg 2189041 gcgtttcgaa ggagccgtga ggcgtatgca ctttgcccag ccgcgctcct gtttgtttgc 2189101 attcttttat aaattcatag cgtattggtt gttcagccac ttttgatgag gcctcctgtt 2189161 ctcaaattat ataatcagca tcgcgtctcc gaagctgaag aaacggtatt cctcttccac 2189221 tgcatggtta taggcacgca gaatgttttc tcttccagca agcgcgctga ccagcataat 2189281 caatgacgat ttcggcaaat ggaagtttgt aatcattccg tcaatggctt taaattcata 2189341 gcccggataa ataaaaatag atgtccagcc gcttgatgct ttaaattgcc cgtcatgttc 2189401 tccggcaatc gtctcaagcg tgcgtgtcga ggtcgtgccg acagaaatga tccgaccgcc 2189461 attttctctt actttgttta aggctgcagc cgtttcttct gacatttgat aaaactctgc 2189521 atgcatatta tgctcttcca cttcatcggc actcacaggg cgaaacgttc caaggcctac 2189581 gtgcagtgtg atgaactcaa tttgcacgcc tttgtctttc agctgctgta agatttcttc 2189641 cgtgaagtga aggccagctg taggcgcagc agcagagcca atttcttttg aatacactgt 2189701 ctggtagcgc tctttgtcat caagctgttc tttgatatat ggagggagcg gcatctctcc 2189761 aagggattca agcacctcgt agaaaatacc gtcatattga aattccatct ttctgccgcc 2189821 gtgctcaagc tcttccgtgc agattgcctt caatcttccg tctccaaatg tgacaacagt 2189881 tccttttttc acccgtttcg ccggtttggc aagtgtttcc catttatcac cggtttcctg 2189941 tttcaacaaa agaagttcca ctttcgcgcc ggtatcctct tttgtgccga ataaccgcgc 2190001 aggcagtacc cgggtattgt tcaggactag acaatcgcct tcgttaaaga agctgataat 2190061 gtgtttaaac gagctgtcag taagctctcc tgtatgttta tcgagcacca tcagccttga 2190121 agcatcacgc tgctccaacg gtacttgtgc aattaaacgt tctggtagtt caaaatcaaa 2190181 taaatcgact ttcatgatga tttcaccttt attctagtct tttgttattt cattctgcca 2190241 aaaagattaa gcaaaattga taataccaca cttataataa tacaagtgac aaccgggaag 2190301 aaaaacgtaa catttccttt ttttacaaaa atatctcccg gcatcttgcc gacaaaatgc 2190361 aaaactgctc cgataataag caaaacagca ccaagaatca taatgatctt aggaaattca 2190421 gtcatatcgg ggagcctcca tttggaaatg atgataaacg gccggtgtca cgatccttcc 2190481 acgcggcgtt ctttgtataa atccaatttg cagcagatat ggttcatata cgtcttcaat 2190541 cgtatgcgat tcctcgccga tggtagctga aatcgtatca aggcctactg ggccgccgtt 2190601 gaatttttcg atcatgccca tcagcagctt atgatcaata tgatccaaac cgaggcggtc 2190661 aacctgaagc cgctccagcg cattctgaga aatgtcttcc gtaatcctgc tgtcacccag 2190721 cacttgggcg aaatcgcgca cccttctcag caggcggttc gccacgcggg gcgtccctct 2190781 cgatcttctt gcaatttcaa gagccgacgg tttatcaatc tcaacctcga atacatcagc 2190841 ggttcttgtg acaatatccg ccagttcttc ttgtgtatag tactcaaggc gagacattac 2190901 gccgaatctg tctcttaaag gagccgtcaa aagccccacc ctcgtcgtgg ctcccaccag 2190961 cgtaaaaggc ggaaggtcga ggcgaaccga gcgggcagat gggcctttgc caatcacaat 2191021 gtccaggcaa aagtcttcca ttgcaggata aagcacctct tcgatcgatc tgtgcagcct 2191081 atgtatttca tcaataaata atacatctcc cggttccagc gccgttaata tagcagccaa 2191141 atcaccaggc ctttcaatcg caggccctga tgtcgtccgc aattccactc ccatttcatt 2191201 agcaacaatc gaagcaagcg ttgtttttcc gagtccgggc ggcccgtaca gaagaacatg 2191261 atccagcgtc tcctgtctca ttttcgccgc atctataaac acgcgcaaat tttcttttac 2191321 cttatgctgc ccgatatact gtgccagatt ttgcggcctc aggctttgct ctatcactga 2191381 ttcatggttg tctgcttcac ttgagacgag ccgttcatcc atgaacatca ccttacttta 2191441 atagtttttg taatgctttt ttcacatatt ggtctgttgt cagcccaatt tcttctttaa 2191501 ggtgaggaag cacctttttg atttcttttt cagcatatcc gagaaccctg agggcttcaa 2191561 gtgcttcttc aagagccgtt tccgctgttt gcttttcaag cctttcttca tgattaaaca 2191621 gattttcaat catttcaggc acaacatctg ccagctttcc ttttaaatct agaataatct 2191681 ggcgtgcggt tttctttcct actccaggaa acttgaccaa aaaagcttca tcttcatttt 2191741 caattgcttg gatgaccgct ccgggatcac ccgagcccaa gatggcaagt gctcctttcg 2191801 ggccaattcc ggtcacgttt aacagctttg taaagagcgc cttctcctct cttgttgaaa 2191861 aaccataaag cgaaaaagca tcctctctga tatgatggta tgtaaaaatc gtttcttggc 2191921 ttctctcctt atatataaac ggattcggcg tgaaaatctg atagccgatg ccgccgttct 2191981 ctatgacaat atattgggga gatacataat caatcgtccc tttaacaaat tcaatcacgc 2192041 aaattcacct ctttgactgt tcttcattgt accataaaaa cagccaaagt cttatagaaa 2192101 agttaacata tgttcgcttc tctctcattc tttcacgaaa aaaaagacat gaatacatgt 2192161 cttcaatcag cggacgctac ccgctgtatg tcttcatatg ttcgatgaca tcctcaaact 2192221 ccgcttttgt ccgaaatgga atgcctttca gcagattttt ttgcatatgg ctttccagcc 2192281 tttctaaatc aatttgaaaa aaagactgaa ttggttcgga agctggctca ggccgcccat 2192341 gaaaagtgga aatcactcca ttatccgata caccgatata cccgttgacc ttgctgagcg 2192401 gagaaatatc gtccatttgc ttccggaaga gcacatatcc ctttttttgt tccactagcg 2192461 tccatccggc ataagctgcc caaaaatcat ccatagaaaa cactttttca tgcttatgct 2192521 caatgctgac atcgccgtcc aaatacacct tttcaagctg cacatgcacc tgcagcggct 2192581 catagtgctc cacttccgcg ccaagtgcgc gggaaggagc tcctattaaa aatactgccg 2192641 ctgagcaaag aatgcccagc aaaagatacg ccgtgctgaa tcgtttcacc ctctacacct 2192701 ctttgcacac gtttatgatt agtttgacca aagaggctac tgcttaaccg ttttatcaaa 2192761 atttgtctgc acattttccc tgacaaaccg ttcctccgta tacacatctg tgctttgctc 2192821 agaaattgtc aagaatcgcg tcagaaaggc actgaaaaaa tacaatgccg caaagatcca 2192881 aatcacgcca cctgcaccga gcggcccaat gaaaagactc acgatgcccg gcgcgataaa 2192941 cgcacataaa ccagatccca aattcaacac tgacatggca gcacctttat tatcaggtgc 2193001 aagcgtcggc aaaagcgcgc ttaatgggac gtaccctgct aaagccgcgc cgtagcagca 2193061 ggcgataatc atgagcaccc aatactgatg cccgatcagc tgaggcgtgt aatacagcgc 2193121 cagcgtaaaa ataccgcatc cgacaccgcc aaaccacatg accgtattgc gccagcctag 2193181 tttatctccg actgcaccga aaatgatatt aaacacaata ttcacaaaaa acagcgtccc 2193241 ccatatttgc agccattccg aaaccgaata cccgtatcgt gctaaataag taggaagaaa 2193301 gatggcaaat ccaaattgtc ctatcgcatt aatcgtcttg accactccgc cgatgcctac 2193361 cttagggttt tcaaacataa tcgtaaatgc cttcgacagt tctttccatt tcggctgatc 2193421 ttgtttttgt atcggagtaa atttatcttt gttaaaaaat aaggcaagaa ttccgcctgc 2193481 cgccacaaac agtaaagcgc tccaaagcgt attgatttct ccaaaggccg gaactgcata 2193541 gctggaatag aacggaccga gcacgttaag gccgcacgta aacataaacc aaaaccagcc 2193601 gacggctttt ccaagaatat tttgagaggt gctgtatgac acccatacga gaaaagagta 2193661 tgcaaacagc ggatatccca agcctctaag agcatagctg cccaagagag ccggataata 2193721 catatgagga atcgcccagc cgataaaagc ggccgaaccg aggataaatg caagcaatcc 2193781 gacagtcatc gtttttctcg gcccccaagt ttggacaaac gttcctgaaa gccaagctga 2193841 gatggtgaca gcaatgccgt acatggtaaa taacgatgcg gattgctgca tactgagacc 2193901 atgatcaacg agaaaaggag acagccagcc ttgttcgagg ccgtctccaa ccataaagat 2193961 gacaacgcca atataacccc aaaccatgtg agaaggaatt ccgattttgt tcaaaacatt 2194021 tcctttagca tgtactgtat tcattttctc caccgcctac ttaaagtatc aatggagtat 2194081 atacccaagc ttgctgaatt gtaatcctgt tagattaaaa agcgattttt tcagtgtgct 2194141 caatgctaac aggcatgcca aaagcaagcg attgctgtgc tgctctggcg atcctcccgg 2194201 cctgtaaacc gtcattgccg gtgcagggag tctcctggtt tgtgccgatc gcttctgcaa 2194261 aacggagaat ctcctcctca tatgaatcct tatagcgttc aaggaaaaag aaatgcggtt 2194321 tatccttcat cacaaaatca gctgttgaca cctcaaccgt tgtcggcctg ctattgtcag 2194381 ccgctgcaga gcctttcgtc ccgaaaacct caacccgctg gtcatatccg tacacagctt 2194441 ggcggctgtt atcaatcaca gccatggcac cgttttcaaa agtcagtgta ataacagctg 2194501 tatcaatatc acccagctcc gcaaaagaag gattcaccaa agccgcccct ttggcataca 2194561 cttccgtcac ttcgcttccc ataatatatc tggccatatc aaaatcatgg atcgacatat 2194621 ccataaacaa tccgcctgac gtacggacat aatctatatt cgggggttct gggtcccggg 2194681 acgtgatttt taataaatga ggtgtaccga tttcaccatt ttcaacaatc gttttgattt 2194741 tcttaaaatg aggatcaaag cggcggttaa atccgacttg aagtgttacc ccgtgtttcc 2194801 ggacagccgc aagcgcttca ctcgtttcgt ccagagagaa actaacgggc ttctcacaaa 2194861 atatatgctt tttcgcctcg gctgcttctt tgatcatctg tgcatgtacg gctgtaggag 2194921 agcaaataaa aatagcatca atatcaggat catgtaataa atcacgataa tcagaggtta 2194981 tgtattcaat ctgatgactg tcggcccagc tttttatacg gctcgcctga atgtcagaga 2195041 ttgcttttat tttcatgtga ggaatccggc ttatattttg aacatgaagt ttgccgatgc 2195101 ggcctgcacc gataatccct gtcacaatct gttttgtcat ggcttcttcc cccttgatca 2195161 ttcacgaaag cgctttattt aaaattaata ctatcccatt tgtaagcgct tttcaagaat 2195221 ggaaattaaa cgttctatgt ctcttttatc acaattcatg cttataagta gccttcttct 2195281 tcaagaccag atacactaga attaggctct ttttcctgaa cagtttatga ttttcctata 2195341 aacagctgca taaaatagag caaagaaggt gaatgaaatg ctgacaaaag cagaggcact 2195401 ggcccatacc gtcatatacc gcaagaacag cagatttgat aaagtcaaag agaaatccga 2195461 ggaattaaca ctaatcggca agggaagaag cgcctatgtg tttgccttaa cagaaggcgg 2195521 tcgaaaaatg gcgctgaaag tattttttcc ggaatatcaa gcgacagcag tcaaagaagc 2195581 agcgatctat gaaaaattag ccgggtccgc attctatcct gacatttacg aaactggcga 2195641 ttcatttatt ctcatggaat atattaaagg tgaaaccttt tataactgtc tgaagaaagg 2195701 cattgcaatc agtgatgaca tgattcagca ggttgaagaa gcgctttctg acgcccgggc 2195761 agccggactg aacccgtcag atattcattt gcggaatctg atattgacag aaaccggggc 2195821 ggtgcgggtg attgatgttg cgagatttga gcagacaaaa acatgcacgc agtgggacga 2195881 cttaaaatcc gcatatcatg cactctacaa aaaaccgata ttccccaaaa agattccggg 2195941 tttttggctg gagatcatcg catttttata taagaaagat tggtttcaaa agcatttcgc 2196001 acagcggaaa agaaaatatt cttaaatcaa aaaggcagcc gcacaagcgg ctgcctttat 2196061 catgtatttt ttactttctg acggcagaaa tcagtttcat ttgttcaggc gacagcttaa 2196121 ttcgatagcc tctcacagtt aagtagaccg cttctgggtc cttctcgccg gaatgacaat 2196181 acgttttttc catttctgtc tcccctcacc ctttattggc tttatttcat cttatcattg 2196241 ctttattgag gtaattttaa agaaatgtaa agattatatg aatccgatat atagtaaaat 2196301 gagagaaaaa aagggagaga gtcacattaa gaccgaaaac accttgagct tagatgcagc 2196361 cagaggtgaa cttgtaaatg aaaaaacact tgtcaagaga acaatctact ggaattaccc 2196421 ggacagccgc ccagcagtga cgtggatcaa tcacaataca gtgaaaatcg gcaatcagac 2196481 tttacatctt gatactgatg aaacgtatga ttggcgaaaa gatgatcatt ggatccgtga 2196541 agaaccgccg caggcgtcag tgaggtgatg aaacatgaat aagatgaacg gaacaaatga 2196601 tgaaaagcat ttcaatcatt ttgtgattgc tttatccttt atatacggtt tgactgaact 2196661 aggctatttg ttgctgaagg attttataac aattgccata agtttgcctc tgtagaaaaa 2196721 cgcagcgtag tcgatacgcc gcgttttttc tttttccctt cctcttctta ttgataatta 2196781 caggtcatat aatgtgacaa atcgattgta gaaatagttc gattagacca aaatcctttt 2196841 tatacatgta ttcgaatttg aagtgagggg gaagcttgat ggcagatttt gttgctagtt 2196901 tgaatgcggt cttatggagt acgcccgtca tttatatttt attgggaatt ggattcgcct 2196961 tttcaattat gacccgtttt ttacaagtcc gacatttaaa agaaatgatt gttcagatgt 2197021 tcaaaggcaa gagctctgaa gccggcgttt catctttcca agcgttatcg attgcgctgt 2197081 ccggccgtgt gggcacagga aacatcgcgg gagtggcgac agcaattgca ttcggcggac 2197141 ccggtgcagt gttctggatg tgggcgattg cctttatcgg ggcggcgagt gcctttgtag 2197201 aatcaacgct tgctcaaatt tacaaagtga aacaagacgg tcaatatcgg ggcggccctg 2197261 cttattatat agaaaaaggc ttaggcatta agtggtttgc cgtcttattt gccgctgctg 2197321 cccttattgc aatggccttt ctaatgccgg gcgtacagtc caactccatt gcggctggga 2197381 tccaaaatgc attcggcatc tctcctttcg tcacagggtg cggtctggtt ttattattag 2197441 ggttcattat ttttggcggc gtcaaacgaa ttgccaatgc ggcgcaaatg attgttccat 2197501 ttatggccat tggatatatc ctgctgtctt tgattattat tgtcatgaat gtgtctgaat 2197561 tgcctgctgt gatctcatta atattcaaaa gcgccttcgc attggattcc gcttttggcg 2197621 gcttgatcgg tatggcgatt tcctggggcg ttaaacgtgg catttactca aacgaagccg 2197681 gccagggaac aggcccgcat ccggcagctg ctgcagaggt ttctcatccg gtcaagcagg 2197741 gactggttca ggcattttct gtttatattg acaccttgtt tgtatgttcc gctacagctt 2197801 tcatgatctt gtttaccggc atgtacaata cccaggctgc agatggttcc tttatcgttc 2197861 accagcttaa aggcgtagaa gcaggacctg gtttcacaca agcggcaatt gacagtgttc 2197921 ttcccggatt cggtgcaggc tttgttgcca tcgctttatt cttcttcgct tttacaacaa 2197981 ttatggcgta ttactacatc gcagaaacaa atatcgccta tttagcacga ggcagagaaa 2198041 gcaaatgggc gatgcttggc ttaaaactga ttattttagc cgccacgttc tatggtactg 2198101 tgaaaacagc ttcacttgct tgggcattag gggatgcagg gcttggcatt atggtatggc 2198161 tgaacgtcat tgccattgtg ctgcttgcca agccggcgct ccttgcttta aaggattatg 2198221 agcgccaaaa gaagcagggc ttagacccga tctttgatcc aaaagcgctg ggtatcaaaa 2198281 acgctgattt ctgggagaaa gaatacactc atgaaagtga acgtgtctcc tgaacatact 2198341 aaaaccggcc cgatatgacc tcgtgccggt tttttatgaa cgatagtttg tatacacttc 2198401 ttgaacatca tcgtcatctt caaggacgtc tattaatgtt tccagcttct caacagcctg 2198461 atcatcggct tctgcatagg tattgggaag catggtcacc tccgccgaag aaattagata 2198521 tttcgattcg agggctgttt tcacctcttc aaaatgctca ggctctgtga aaacctcata 2198581 taggtcttct tcaattcgca gctcttctcc tcctgcttca agcacatcaa gcatgagctc 2198641 atcttcttct atttgccgtt cagtacggtc tatcgtaatg aacccctttc gttcaaataa 2198701 aaaggctaca catccgcttt ctcccagact tccgccattt ttattaaagg ctgtccgcac 2198761 atttgacgcc gttcggtttt tattatctgt tacgcattca accatgacgg caatccctga 2198821 agggccgtag ccttcatagg tgatttcttc atagctgctt ccgtcttggc ctcccgcagc 2198881 ttttttaatg gcccgatcta tattttcatt cggcatattg gcgccttttg ctttttcgat 2198941 gacaagacgc aatgctgaat ttgcttctgg atccgctccg ccttctttcg ctgccacata 2199001 gatttctttt gccagcttca taaatatttt cccgcgcttt gcatcctgtg cattttttct 2199061 tttttgaatg tttttccact tggaatggcc tgccatgttt tcaccttctt ttacattttc 2199121 tatgtacact ttaatgggaa atgttcgctg atgcaaagaa aaaggctgcc gaatatcact 2199181 tccggcagcc cttccttcct agcggttgtt cattttatga agttttctga acagcccttt 2199241 atctgttgat acttggacgt cacggccatt tgcatagttg cgcgctgctt ttacaacatt 2199301 atctctgtca gactttgtga actctctgtg gcttttgact gcgataacta ctcggtcatc 2199361 cgataccata acttgtgtgt cattgacgtt tttcacttgt ttcacacggt tggcaatttt 2199421 tgcagccagt cttctgtttt cttggttgtc atacccgttg ttcgctgcat tccgattcat 2199481 gtttcggtta ttcgtgttgt tatatgttcc gtcagttgcc aaaggaacac gatcgtcagc 2199541 agtaacacgg tcacggttat ttacattcgt ggtgtttcgg ttaccgtcgt tctgatcctc 2199601 cattaattca gaaacaggac catcgtggtc gattccgtct ccctgtctat cggcgtcatt 2199661 ttcatttgta taatatccga ttggacgggt attgccgtta ttgcgcgtat cattcatagc 2199721 attatcgttt gctccgcatg ctgttaagcc ggctgtcatt agaatcaggc tagcgatcgt 2199781 cattttttta cccaatggaa aaaccccccg tggacgaatt gagcatgttt gctcgctttt 2199841 atcatgtgcg tatggggggc atgttaagcg tgtcagttct ctccatttgg cagtgatctg 2199901 cttgaaaaca aaaaaaggaa cgatttacat cgttccgaac gatcactcat tttcttcttc 2199961 cggacggcca aacatttggt ttacagaagg ctggttcgtc attggcatag aaactcctgc 2200021 cgaatatggg tttggatttg ggttagctgt gccatatggc atattagggc ttccataagc 2200081 tcccattccc gaatggccag gtgcagagaa atatggctga tgatcaccgt cacagccgca 2200141 gtcgtcatga tctttgtatg gcatgtaacc atgagccgca gcaggctggt atgctcccat 2200201 tacttgggga gtgccgtaat aagggccata cggcatatgt ccatacggag atccataagc 2200261 cggagatgcg tattgcggcg caccgtatga accgtaatgt ccgtgatggc tgttttcatg 2200321 atgctggttt tcataacccg ggtcatactg aggcgataca aagcctggct ggtatccatg 2200381 catcggatgc attggataag cttgtgccgg atagtacgga tagcataatc ctgatcctgg 2200441 aagaattggc gaaacaggca ccggacacgg tacgaaatga gccggataat gataataagg 2200501 ctgaacagcc ggcatcggca tattcggaac tgtgtgatga acgttttcct cttctatacc 2200561 gcctacctct ggcgcctttg gcatattagg catattcgga taatttgcat tttccatatt 2200621 actcatagcc tcctgttgtg gaaattggtc ttgcatatga tacatatgat ccatatttcc 2200681 gtcatgatgt tttttcggct cctccggttt aggaggcgac caaggctgga aaagctgttt 2200741 catatcataa taatcgttca catcagcttc agggtacaca ttttcctgca aattaggcat 2200801 cggcgggaca tacggcatgg acttcttttc tttcggcttt gtgtcttcta catcgacaac 2200861 ggatttaggc ttctctttcg catatggatg ttcttgcttc acactcccgg ccgcaggact 2200921 tttgcccgct tttggctctt ttctgaccgg gactccttct gacggcactt ttattttcat 2200981 tccaggcatg attaagtctg gattgctaag ctgtgtattg agttttttca cttcctcaac 2201041 atcgactccg tacttttcag ctattttcca gagcgaatcg cctttttgaa cgatatggat 2201101 tttcaacgtt ttcccctcct atgcaaaacg tgaacagttc agctgtgatt acaatatgtt 2201161 tcttcacaac atatgcctga acaaaagaag ttatgagtaa aggaagggaa aatatttctg 2201221 atctacgtga tcgaaagcat tcgattcagg gcaaggagtg catcttcctg aatggctttt 2201281 ggcaccttga tgacgcctga aggttctcct ttttcaattt gttccagcga ccacaacaaa 2201341 tgcggcaaat caattcggtt cattgtcagg caagggcaca tgtcagggtt gagtgattcg 2201401 atttgtttat ctggatgctc gtgaatgatc cgctgaacaa gattcatttc tgtcccgatt 2201461 gcccacttgc ttcccgccgg agcctggttg attgtgtcga taatatattt cgttgatccg 2201521 ttatcatcgc ttagtgtcac gacttcgtgt gaacattccg ggtgcacaat gatctgaatg 2201581 tcggggtctc gctctctcat atcatggata tttttagtgg tgaatttctc gtgaacagag 2201641 caatgccctt tccacaaaat cactttcaca ttcgtatgcc cggattcagc tactaattca 2201701 tctttcatcg gatcccacac agccatatct tcaagcgcaa tgcccagatc ataagccgta 2201761 tttctcccta aatgctgatc aggcaaaaat aaaattcttt ttttctgtgt aaacgcccat 2201821 tcaagcactt ttttcgcatt cgaagaagtt acagttgctc cgccatgctt tccgacgaat 2201881 gccttgatct ccgcagtgga gttcacataa gttaaaggta tgatcgtatc tccaaatata 2201941 tgctgaagct tcttccatgc cctattggtc tgctgcatgt cagccatgtc agccatagaa 2202001 catccagctc tcatatctgg caggacgacc gtttgctgct cgcttgtcag catatcggcg 2202061 gtttctgcca taaagtgaac gccgcaaaat acgatataat ccgcttcttt gtttttttcc 2202121 gctacttggg ccaattgcag ggagtcgcct gtttggtcag caaattgtat cacttcatcc 2202181 ttttgataat gatggcctgg tataaagagc ctgctgccga actttttctt aatggcggca 2202241 acgcgcgttt ccatatcctt tctcgatagt tctttataac tttcgggcat catatcattc 2202301 gattgtttga tcacatcaag aattgacata acagcattcc tccacagatt catttgataa 2202361 cgtaacatcc atgctgatat ctaaactttt gacggaatga gtcagaaatc ctaatgaaat 2202421 ataattcaca cccgtccctt taaaagcagg caaagattct aacgtaatcc cgccagaggc 2202481 ttcagttttt atattagccg gtgtgagctt tgcaaaatga cggaccgtat caggcggaca 2202541 gttgtcaaac ataataacat ccgctccagc tgcaattgct tcccgcagct gttcctccgt 2202601 ttcaatttcc acctcgatat ttaccatgtg ccctgcggcc tgacgggctt ttttgcacgc 2202661 ctctaaaata gagccgcatg ctgcgatatg attatcttta atcatgatgc cgtcatacaa 2202721 accgaatcga tgattatacc cgccgccggc tctgacagca tatttctcca gcattctgag 2202781 ccccggtgtt gtttttctcg tgtcacaaat tttaatctgt tcatcatcca gacaccgaac 2202841 agcctctctt gtcattgtcg caattcctga cagcctctga ataagattta atacgacccg 2202901 ctctcctgaa aggagcgcag ctgcgggacc gtgtaactcg gcaatcactt cacctttatg 2202961 caacatgtcc ccatcttttt tgtgtaaaat gctttgaaca ttttcgtcca ataacgaaaa 2203021 gccttctttt atgatcgctg ctcctgcaaa aataccctct gactttgcaa caatctccgc 2203081 ttcacagctc tgttctccaa aaatagactg cgatgtaaga tcccctgtcc caatatcctc 2203141 aagaaaaaag tgattcagta attttttcag ctgtaaatga ttcattgttc caaatcccct 2203201 cgttttttct gatcttcgtt cctttttttg tatggacaat ttgtcttcct tgccagctca 2203261 cctcagcatg aggaaaatcg gtgcggaagt gagcccctct gctttcctcc cgcaaaagcg 2203321 cagaaaacgt catcagcttt gcagtttgcc atagatgaga aagttccatc tgccgaattg 2203381 tgatatcctt cacatttact tcctgaaaag gcagcgtatg aagccagatg ctaagctcaa 2203441 tcaaactgct ttgttcccgc agaatagaca tgtggcttgt cattttgctt tgcagttcat 2203501 gcccctctat atccggcacc tcgtagaaga cactggtttc tagccctgat tgatattgcc 2203561 tgttataaac cggtttttgg ataatatgct ctgctgccct ttttccaaat accagcgctt 2203621 ccaataaaga attgcttgca agccggtttg ctccatgtaa accggagcat gctgtctcgc 2203681 caatcgcata aagccccggc actgtcgttt ctccccagcg attaactgaa acacctccca 2203741 ttaagaaatg cattcccgga gcaacaggaa tttttccgct gtggatatca atccctgctt 2203801 tttcacaaat agcggtgatg gtagggaaac gcgtttcaaa atcagaaatc gcactgaagt 2203861 ctatataaac gcgatttcct tttgccattt cttcgtgaat aacccgtgag acaatatctc 2203921 ttggagccag gtcacctaaa ggatgccgtt cagccataat cctgcggccg ttttcgtcta 2203981 ctaaacatcc gccttcccct ctgacagctt ctgaaacaag cccgtaggaa acaccatttt 2204041 tcacaagcag tgtcgggtga aactgagtaa actccaaatc cgttaattcc gccccggccc 2204101 ggtaagccag agaaagaccg tcacctgtga cagtgagatc attcgtatgg tgaagaaaca 2204161 ggtttccaca gccgccggca gccagcacaa cttcgtctgc gtgccttacc ttgagccgcc 2204221 ctttgctgtc ttttgtcatg acgccgatac atcgtccgtc ctctataagc aaatctgctg 2204281 ccgtttcatt ctcgattaac ttgattttgc tgttgatccg tttgagcaaa taatcgataa 2204341 gcagcctgcc tgttgcgtct ccgcctgcat gaaatatgcg gttgtatgag tgggcccctt 2204401 ctcttccaag acaaacaccg cctcgttcat tgcggtcgaa tggaaatcca cgctccaata 2204461 ggctttgaac catcattttt ccatcatgta atacgtctgc tacaatagct agattattat 2204521 ggccgcaccc tgcgtataac gtatcctcca gatgggcttc aatcgagtca tcttttgcat 2204581 aggccgcagc aatcccgcct tgtgcataga cagaattgct gtttttgacg cttttttttg 2204641 tgataacagt cacttcgtat gagggcggga aagctgcagc taaggaaagt gccgccgccc 2204701 ctgaaccgat gactgcaatc gtctttttag acatatgcca tcctcctgtt gtttacacct 2204761 gtcttgacac ctatatttac acaaggataa aataaactca agagtttttt atggagaacg 2204821 gatggaggaa gaccggatga tttatttaga ttatgcagcg acaacgccta tttgtgagga 2204881 agcccttact gtatatcaga agcttagtat ggatatgtac ggaaatgcca gcagcctgca 2204941 tgatgcagga ggaaaagcaa agcacatact ggagtactgc cgtgaaaaaa tcgccaacat 2205001 cattggcgga gaagcaagcg gcatctattt tacaagcggc ggcactgaat ccaattttct 2205061 ggccattcaa tcattgttaa acggcctgcc aaaaacgaaa agacatttta ttacgactgc 2205121 catggagcat cagtccattc ataattgcgc tgcttttttg gaacagcagg gatatgatgt 2205181 aacagtcatt gaaccgaatg aatacgggct tattaccgag gaaatattac taacccatat 2205241 ccggccggaa acaggccttg tatctattca gcatgcaaat tctgaaaccg ggatcattca 2205301 gcccattcaa cacctgtctt catacctgca caataagggg attcttcttc attgcgacgc 2205361 tgttcaaacg tttggaaaga tcccgatcaa tacaaaaaat ctgggagtag atgcactctc 2205421 aatgtccagc cataaaatcc acggtcctaa aggagtaggg gcggtctata tccggccgga 2205481 tgtcccttgg aaacccgttt atcctctgac tactcacgaa tacggattca gagccggcac 2205541 cgtaaatgtt cccgggatcg gtgccttcac tgccgctgca gaattgatcg taagcgaaat 2205601 ggaaaaacag atatcccgca atgaggcatt aagaacatac tttctagacc aaatccgtat 2205661 tcggtctctc cctgtaaccc ttgcagcaga cacttcgaaa gcagaatgtc ttccgcatat 2205721 tatagggtgt ttttttcact catttgaagg acaatatgtt atgttagaat gtaatcggag 2205781 taatatttgc atttcaaccg gcagcgcttg ttctgcaggt taccacggtc cgtctgaaac 2205841 aatgaaagca ttaagaaaaa ccgaacaaga agctctgcaa tttatccgca tctcttttgg 2205901 caggcataca acagctgaac agctggaaca gttattacat acgtttacag tgctttggga 2205961 acaaaagaaa ggagaatttg atattgaccg aagaattaaa gctaatgggc gccaacaggc 2206021 gtgaccagct tcttctgtgg ctgaaggaat ctaaatcacc gctgacagga ggagaactcg 2206081 caaaaaaagc gaacgtctca agacaggtta ttgtacagga tatatcgctc ttgaaagcga 2206141 aaaatgtacc gattatcgcc acaagccaag gatatgtata catggatgca gccgctcagc 2206201 agcaccagca ggcagaaaga atcatagcat gtctgcacgg tcctgaacgg acagaagagg 2206261 aactgcagct catcgtcgac gaaggcgtta cagtaaaaga cgtaaaaatc gagcatcccg 2206321 tatacggaga tttaactgca gccatccaag taggcacccg gaaagaagtt agccatttca 2206381 tcaaaaaaat caattctacg aatgctgcct acttatcaca gctgaccgac ggcgtgcacc 2206441 tgcatacact gacagcacct gatgaacatc gcatcgatca agcctgccaa gccctcgaag 2206501 aagccggcat tttaattaaa gactaaaaaa agccctctag tgggcttttt ttataattgg 2206561 taagactggt atgcacccag aagcctcact ttgcagccga gtgcttcaag ctcctgcatg 2206621 gcccctggaa tcaatacatc atcaaacgct ttctcaatat caataataaa gaaataatgg 2206681 cctaatccgg ttttagtcgg acgtgactca atttttgaca ggtttaaatt tctccaagaa 2206741 aatgcagaca gcactctatg cagcgccccg gactgatcat cctgcggcag catgaccatt 2206801 aaggtcgttt tgggcctaga gctcaatttt gaattcactt caaaagatat gttttcatcg 2206861 ggagacagga taacaaatct tgtatgattg tccctataat cctgtatatc ccgtttcacg 2206921 atttttaatt cgtatgtaga agctgccata tcattggcaa tgaccccgat attcagctcg 2206981 ggatggtcac tgacaaactt tgctgccgcc ccggtagaat tggcgtattc atatggaacg 2207041 gaaggaaaat gtcgatgaag aaatttatgg cattgcgcaa tcgcgtgtga atgtgagtaa 2207101 attttgtcga gctctttcca tgcattctct cttgagggat ggacgagcaa gtgctggtga 2207161 atcggcaacg tcatttcacc cacgattggc aaaggctgtt catgtattaa atagtctatt 2207221 gttagattaa cagatccttc taaagcattt tccaaaggaa caaaagcaaa atcaacttcg 2207281 cctgcaacgg ctgcatctat acactccgga atggtgcggt aagcaacatg ttcggcgccg 2207341 ttttgaaaac aagaactgac tgctagatgt gtaaatgtag ctgctggacc taaataaccg 2207401 actttcatga cgattttctc tcccttatgc acctgaacct aatatttcaa ccttttctac 2207461 aaaatcaaac ttcctgagct tattcattaa tgtatgaatg tcttcttcca ttgccgacgt 2207521 actgatagac agtgtcacat ttgctctgcc ttgaagcgga atggtctggt gaatggaaag 2207581 aacgttgctt ccagaatcag ctaccgcctg aagaagctga gataacgcac ctgacctatc 2207641 ctccaaatga aagaaaagtg tgataatttg ttcttttacc atggtgtaga atggaaaaac 2207701 agcatccctg tatttataaa acgcacttct acttaaatcg accttttgaa cggcatctgc 2207761 tactgaatct gctttttttc gatcaagcag ctttttgact tctaatgttt ttctcattgc 2207821 atcgggcaat acatcttcac ggacaagata aaatgtctcc tctttcattt gcatcccccc 2207881 tttaaaatag agagcctggc accaggctct cttttcagcc aacattgatt aatcaataaa 2207941 ttcaaattca aattccagaa gcctgattat atctccatcc ttggctccgc gttctctgag 2208001 tgcttcatca acacccattc cgcgcatctg tcttgcaaac cgtttaaccg attcatcacg 2208061 tgagaaatca gtcatcttga ataaccgctc aaggctgtct cctgaaagca caaatacacc 2208121 gtctggatcg cgtgtaatgt taaatggcac ttcttcattt tccatcgtgt acatgacacg 2208181 gttttgtgta agctcttcct cgtcatacag cgggaattcc ggtgtgttct caagctgatt 2208241 ggcaacctca aacagaagct cacgcagacc ttctcttgtc accgcactga tcgggaatac 2208301 cggataatca tccgtcagct tttctttaaa ggcttcgaga ttttccgcag cctccggcat 2208361 gtccatttta tttgcaacga taatttgcgg acgctcagtg agacgcagat tgtactcgct 2208421 cagctcctgg ttaatcgtaa gataatcatc atatggatca cggccttcta agcctgacat 2208481 gtcaatgaca tgaacaataa ccctcgtccg ttcaatatgg cgcaaaaact ggtggcccag 2208541 tccgacgcct tggtgtgcgc cttcaatcag ccctggcaaa tcagccatga caaagctgcg 2208601 tccgtcatcc gtttcaacca tgccgagatt cgggacaagc gttgtaaagt gatagtccgc 2208661 aattttcggt tttgcagatg agacaacaga cagcaaagta gattttccca cactcgggaa 2208721 cccgacaagt ccgacatctg caagcacttt taattcaaga acaatgtagc gttcttttcc 2208781 cggctcgccg ttttctgaaa gctgaggcgc gggattagcc ggtgtagcaa agcggctatt 2208841 tcctcttccg cctcttccgc ctcttgcaat gacagcccgc tgtccgtgct ctgttaaatc 2208901 agcgatgacc tgttttgtat catcgtctgt cacaacggtg cccggcggaa ctttaatgac 2208961 catatcatca gcatttcgcc cgtgctggtt tttggacatg ccatgctcgc cgcgaatcgc 2209021 tttaaagtgt tttttgtatc taaaatccat cagggtgcgg agaccttcat ctacttcaaa 2209081 aacgacgtct cctccctttc ctccgtcacc gccggcaggg ccgcctttcg gcacatattt 2209141 ttcacggcga aacgcaacca taccgttgcc gccgtcgccg ccttttacat atactttgac 2209201 ctgatctaca aacataatgt cctccgttct aaaccgttaa aaactccgct agtccaaccc 2209261 aatttcaatc agacattcgt gactcgtgat ttcaaaacgc atgatatcaa cgtcctcata 2209321 tccattctgc cgaatatcat caaaagcaga tggatcggca aaggcgccgt gaaaatcaag 2209381 gtacagaatc agctgtctgt caggatgatc cgtttgaagc gaaaccgtta aatgattttc 2209441 actctctctg ctgactgctt gatcaaacag atgaaacagc tttctcatca gtttcgccag 2209501 cttttgatca taagccgaca aatccttaat ttctccgaga acttcatatt caagcgtcat 2209561 ataatgggtt ttccaattaa acgtaagaaa atcaaacgcc aaatgcggtg ttttcaggtt 2209621 tgagagcttt gattcgtgct ttgcgtctat aaccatttct tcaatcattt caaagacacg 2209681 gtcatacttc tgtaagctta agtttccttt aatcagctgc agcttattca tccaatcatg 2209741 ccgggaatgg ccaagcagat gaatcagttc gtttgttaat gccgtgtcgc ttatattttc 2209801 ttcttgattt tttgaaacat ccttcatttt cgcactccca atcatttaat ttcttattta 2209861 ggagtctgta taagtgtgta ttatgaatta taacagagaa ggctttgtta gaaaaacaat 2209921 tgtttttccc agaaatatca tgttcctttt ttctggcttt ggttgatttg cagccaggca 2209981 gaacatttta tgtattactg cttggggaac atatccagtg ggtttgagat gtttattctc 2210041 attcttggcg gggtctgctc gcacatactc tgcatttcat tctaggtgtt tactccgcat 2210101 attgcaaaaa aaactccagt catcatcgac cggagttttt tgaatcatta ttgagctaca 2210161 ggatatacgc tcactttttt gcggtcacgg ccgaaacgtt cgaatttaac agttccgtcg 2210221 attttcgcaa atagagtgtc atctccgccg cggcccacgt tttcacctgg gtaaattttt 2210281 gttccgcgtt gacggtaaag gatagaaccg cctgttacga attgaccgtc agcacgttta 2210341 gcacctaaac gtttagcctc agagtcacgt ccgttctttg tagaacctac tcctttttta 2210401 gaagcgaaaa actgaagatc taatctaagc atgtagctca cctcctatat tatgtttgtg 2210461 gtcacacgca agttgtcttt gtaatcccgt tcgattgtct ccagcgaaac aatcatgcct 2210521 tcaatcagca gctgagcttt ttggcgtgcc tctggatcaa gagattcagg gaattcaaaa 2210581 taaaaataac ccccgtcctc tcctatatca agaagcggct cgaagcccgc gagcacaatg 2210641 accgcgttaa cggccccaaa cacaacggct gtcactccgg cacaaacaag atcttgtcca 2210701 tgttcagcaa aattcgcatg gcccgtcatt tcaaaagaca atatgccttt atcatgagac 2210761 cttctgattg ttgcctgaat catgcttacg cgttgatttt ttcgatcgtc actttagtgt 2210821 aaggctgacg atgaccttgt tttttatgaa cgtttttctt tggtttgtat ctgaaaacag 2210881 tgattttttt cgcgcggcct tgtttttcaa ctttagccgt tactgttgcg ccttcaactg 2210941 tagggttgcc gactttcacg ttgtctccgc caacaaacaa aacgtcttca aaagtaactg 2211001 tttcacctgc ttcagcagca agtttttcga tgtaaacagt ttggccttct tcaactttga 2211061 tttgtttacc gcctgtttta atgattgcgt acattctctg cacctcctat tagactaaga 2211121 ctcgccagat accagggggc tgtaaaagct cttaacacct gtactgagcg gttgtagcaa 2211181 tggtgctaca tccataacat taaaaaatat accaaaatac aaggcgtttg tcaatcagtt 2211241 ttagtagggc agaagcagtt cctccatgga agaattcgtc cgcttatcgg caaagtaagc 2211301 gtgcagcact tcattctcgt caagctggct gagcttttgg cctgattttt ctataataat 2211361 cggatgctta cagccacgtt tgaactcggc catcacatga tagactttat cctccgcctt 2211421 tactgtcagc ggcagaagtt tctcaagctc cctgtttttt ccgtaatacc tttcgaggag 2211481 aaatctcaca tggatatagt gcctttgccg atattcctca aacaaggaaa cagccagaaa 2211541 gacaaacaaa acccatgcgc tgatttgcag aggaatcacg aataaaaccc agcacccgag 2211601 cagcaggcag aagcagagcg acgtttttag attaagccgg tgagcctttt gaaaaggcag 2211661 ctgtttggaa aacaacaaaa ataacagttt tcctccatcc agcggccaga tcggcagtaa 2211721 attgacaaat aagatagaaa gattataaaa ggtgaagagt tcaaaggtat gctgatgaat 2211781 cactgagact tctgcaagca tccaggcggc aaactgaagc cagatgtgct gaagaggtcc 2211841 ggcaataatg accgcaaact cttcctttaa cggccgattc ccgtgctctt ccacttcgac 2211901 cgttccgcca aacggcagca aaaaaacacg cttgattctc caagaaaaaa acacagccag 2211961 agcagcatgc cccagctcat gaatcaatac aatcaggagc agacataata atgctttcat 2212021 atggcctgtg agcaagccca gcgccgcaat aatccaaaga aaaggatgca catggatctt 2212081 taagataagg tcgagccatt tattcaaatg aaatcacctg aatcggatca ataaatttat 2212141 cgccgtcttt catggcaaaa taatagaccc ctttattatg atcatcaagc ttaatcgaac 2212201 cgagcttttt gcctttatcc acaaaatcat ataaagcaac atccacatct ttgagctcgc 2212261 catagatact ataggtgttg tcagcatgct gcaccttaac cgtcagtccc gtttggctgt 2212321 ctttgctgac ttcaaccaca tagccttctt ttacgctatc aatcttatca ctgcttgttt 2212381 cgactttaat tccttcccca ttgtcctgaa aatcctgctg tactttcccg gatgcaggcg 2212441 cgatcagatc tttgcctact tcaatctgct gttccttatt tttgtgttca ggagccagga 2212501 aagcaagcgg atttccgaat ttggtttcga accaatggct tgctgaagca aattgaaatt 2212561 cagtttcaaa ggttttggct acggcgggtt taatctgact gacgggtcca atgtttgttt 2212621 tataggctat agctgaaacg agaacaaggc aggccgacag aagacatttc aggataattg 2212681 aatctgtttt caccaatggg tgttttccgt tgaatgttgg catgttatct tcgtagaccg 2212741 gaagtgttcc atgcttttcc tgatccgtta ccatcaccca ggacgggggt ttctgctttt 2212801 cagaaactgt ctgagtagag aaacgttttg agccggaaag ctgctttctt cttttctcta 2212861 atcgttttct gatttcatct gctctgtgac tcattgccat catcctttgc attcgttggg 2212921 tttgtacatc atatgtcttg tccatggcaa atattcggtt tagtcaagaa caaagcaggc 2212981 aaaaacaaaa aaaacctgac acagcatatg ctttgtcaga ttcttctctt tgattctatc 2213041 acattaagat cttactccga aaaatgactt aatcttagcc atcattcctt tgttttgctc 2213101 ttcaagcacc tgtaaaggaa cagattcacc taagatgcgg cgggcaatat tgcgatatgc 2213161 aatggaagcg cggtttttag ggtccatcgc aatcggttcg ccatgattgg aagctttaat 2213221 gacttcatca tcatcagcca cgattccgag caaatcgatc gacagatgct gtacgatttc 2213281 gtcgatatcc atcgtgtcac cgtttttcat caggtgattt ctgattctgt taacaacgag 2213341 ccgcggcggt tcaatatttt cctcttgctc cagcagtcct ataatacggt cagcatcacg 2213401 aacagctgag atttcaggcg tagtgaccac aatcgcttta tcagctccgg aaacggcatt 2213461 tttgtaccct tgctcgattc cggcaggaca gtctatgatg acatagtcaa attcctgttt 2213521 gagctcttgg accatgtttt taatttgttc aggagcaaca gctgtcttat cgctcgtttg 2213581 agcagcgggc attaaataga gcagatcatc gaaacgtttg tcttttacga gcgcctgatg 2213641 cattttgcat ctgccctcta caacgtctac cagatcgtaa ataattctat tttcaagacc 2213701 cattacaaca tcaaggttgc gcagtcctat atcagtatct actaagcata cgcgcttccc 2213761 taaaatggct aaggcggtac cgaggttcgc agatgttgtt gtcttaccta ctccgccttt 2213821 tcccgaagtt attacgatag cctcacccaa ttcacattcc tccctcaagc cttgttagat 2213881 caggtcttaa atgagccaaa tgttgaaggc gttcaatgac catatttccg tctgtatcta 2213941 aataagcaca ttccatttcg ttcccttttt gaatgtggtc tggggagcga tttaacacat 2214001 gattgattct taattgtgtc ggaagcattt cagaggcggc gatgaccgct tgattatttc 2214061 cattgaatcc agcatgcgca attcctttca gtgagcccag aacaaaaatg ttccctccgg 2214121 ccctgactgt tccgccggga ttcacgtcac cgatcaggag caagtcgcct tttacctgca 2214181 gcacttggcc tgaacggaca atttttgaaa cagaaataat ttcggcttcc tctcttatct 2214241 gctgtgcttc ttttttagta atgacttcac tgtcaataga atgaacaaac aaatctttct 2214301 ttgacgcaat caattcggtt agctgttcct cttgctcctt atataaaaag cgatttccca 2214361 gcttaacatg aacgctgatt ttctggcctt ttccatcggt atattgttca attgacagca 2214421 tattctgaag accatcgaga agctcatcaa aagaacacgc atcatccaga tgcaatgtta 2214481 gtccattctt tgttcctttt attgttacat attgctgctt tttggtcttc acaatattca 2214541 cctcaacaac atactcattt cgtcaaaaaa agataaaatc ctttttactc atctctcaat 2214601 tctttcttta gactcataaa aaacaatcta aatggcagaa caagaataag agctgctgca 2214661 atatttaata aaattgtcgg tataaaccgg tcaagcacaa atccgttaaa cgtcataatg 2214721 tctttatgaa tcaaagactg aatgccgaat acgtaaaatt cgagcagaca gacagccaga 2214781 actgctatca atatcactac aaatgcgttt gtatgcaaca ctttaaacgc ttttgaagcc 2214841 aaatagcata gccctgcaaa accaaacatg taaacgccta atagacttgt atagttcatg 2214901 tcatatagaa agccaaaaat aaatccgtaa atcatcgcgt gtttttggtt gataaaagcc 2214961 gacatgaata tcaatacaag catcaaaaaa cgcggggcga gcacttggtc atctgtaacg 2215021 aaaggaaaat gcaccaaatc tgtaaaaatg ctttccgcag aaaaaacaag catcataacg 2215081 aaagggagaa ggaaacgttt cacgatcctt cctcctctgt atcgacagtc ggcacgtcac 2215141 ggttaacaac gatcacatta tttaaatctg taaggtcagc cgcaggtttt acataagcaa 2215201 ccttcgttaa tccataggaa tctgactcga tatcagtcac ttcaccgatt gtcagccctt 2215261 ctgggaaaac accgcctgtc cctgatgttt caataagatc gccttttttc acgtcttgtt 2215321 tatccttacg ctcaataatt gtcatcttaa gacgtttttt ctctttgtca tatccttcga 2215381 tcaagccgta gcctttgctg cctttttttc cggaaatttt tgtcgcgact ctgttattgc 2215441 ggtcagtatc gcttaaaagc tgaacagcag acgtaaaatt gttaagtccg gagcttttga 2215501 tcttgccgat taatgcgcct ttttcgtttg taacggccat atctttcgct acgttttgct 2215561 gagtcccctt gttaatggtg acctgtttcg cccaattatc agggcttctg gcgatgaccg 2215621 ttgctaaaat cggcttgtaa tctttaatcg atttgacatg gccaagctcg tcacgcaagg 2215681 atttgttttc ttcttcaagc tcttgaagct tggcttcata ttgtgtctgt ccgtcaagtt 2215741 tttctcttag acgctcgttt tctttgtatg tgttttttaa atcattgatg ttctcaaata 2215801 ttcctgcaaa aaattcggca ggcgtatgaa aaatattttg aaatactccc gtcgtatcgc 2215861 cgatcacttt ctcaggccag gtggtattgc ggccgccctt cagcgaaaat ccaatcatag 2215921 ccaccaatat gataatacac agaagtaata gcattaaccg cttattcggc atcgtgttac 2215981 acctcttcta ttgaactccc gattatctag ttttcccttt gaaaagatgg atgtgctcca 2216041 gtgctttccc tgttccgatc gctacacaat caagcggatc ttcggcgata aggaccggca 2216101 tttttgtttc ttcgctgatg actttgtcca aattgcgcaa aagcgctccg ccgccggtta 2216161 acactatacc tctgtccatg atatctgctg caagctcagg cggtgttttt tcgagtgtgc 2216221 tcttcactgc ttcgacaatt gtagatacag tgtcgcgtag agcgttagaa atctcttttc 2216281 ctgtaatttc aattgttttc ggcaaacctg tgagcaaatc gcggccgcgg atttccatgt 2216341 tgtcggattc ttcaggagct tctgcagatc cgatttccat tttaatcgct tcagccgtac 2216401 ggtcaccgat catcagattg tacgtttttc tgatgtagtt gataatcgcg tcatccatct 2216461 catcaccggc tacacggatt gactgagacg ttacgatgcc tccgagggaa ataatcgcaa 2216521 cttctgtcgt accgcccccg atatcaacaa ccatgcttcc agtcggttcc caaactggca 2216581 gattggctcc gattgctgcg gcaaaaggct cttcaatcgg atacgcgtca cgcgctcccg 2216641 cctgtcttgt cgcatcgata acagcgcgtt cttcaacagc tgtaatgcct gatgggacac 2216701 ataccattac atatggtttt ctggcaaaca tgcctttatt ttttatggcc tgattgatgt 2216761 aatatttcat catcgtcgcc gttgtttcat aatcagcgat aacgccgtct ttcatcgggc 2216821 gaagagccac cacgttgccc ggtgtccgtc caatcatatt tttcgcatca tttccgacag 2216881 cgacaatcga tttcgtatcc gtctgcaaag cgacaactga cggctctctc acaacaattc 2216941 cttttccttt tacaaaaaca agcgtattcg cagttccaag atctatacca aggtctctag 2217001 caccaattcc aaacatatgt atgtatcttc ctttcttaaa gcaaaaatac cctaaaggga 2217061 aaaactcata aactctatta tagcttaatt cgacgaaaaa aaaagtgtta caaatatcct 2217121 ttttccttta aactcacaaa ttttttatcc ccgatcacca aatggtcaag cagctcgatg 2217181 ccaatcaggt ttccgcattc aaacagccgt cttgtcactt caatatcttc cctgctcggc 2217241 gtcggatctc cagaaggatg attatgaaca cagataaagg aagcggcaga tcgtttaaac 2217301 gcttctttaa acacctctcg cgggtggaca atagatgaat tcaggcttcc gataaatacg 2217361 gtgcgtttat ggatgacttg attttttgta tttaagtata aacagacaaa atgctcctgg 2217421 gttaaaaagc gcatatcctc catgacaaga ttagcgccgt cttccgggga gcgaataacg 2217481 aaatgttctt cgttggctaa tttatgaatc cggcttccaa gctcaactgc tgccagtatt 2217541 tgaatcgctt ttaccatacc gattcccggg atgcttgaca gctcttcaac cgatgcttcc 2217601 ttgagcaggc gcagcccgtc aaatgagcgc agcagccggt ttgacaggtc caaaacagat 2217661 tcgtgtttag tccctgtccg caataatata gccaaaagtt catgattcgc taagttctcg 2217721 gctccgactt tcaggagccg ttcccttggc ttttctttca ttgggaaatc tttgagtttt 2217781 aatggcagat cgtgtatgac caagcactcc ttttctttcc cttcccgttt atagaaccgt 2217841 catgccctta tatcaaaatg gcgaagagct ctcattgttt ttgatatagg aaggcccatg 2217901 actgaataat aatctccgtc tattttcttt acaaaaagcg cgcctcttcc ttggatgccg 2217961 tatgcacctg ctttatccat cggctctttt gtttcaatat atgtccaaat ctcttcttca 2218021 ctgagggacc aaaacgcaac ttctgtctta tcataaaaag tctcgctgtg attttcagct 2218081 tgaatgctga ccgcggttat tactgagtga cttcggcctg aaagcctccg cagcatagaa 2218141 gcagcttctt cttgatcctg cggtttgcca agacattcgc cgtcaaggca taccattgta 2218201 tcagcaccga taacgattgc atgcgggtgg agatcagcta cagccttagc tttttgtttt 2218261 gccaaccatt ggacgttttc ttctggtgaa aagtttcgat ttaatttttc ttctacttca 2218321 ctgacaataa tggagtaggg cagctggaga agatcgagga gttctttcct gcgcggagat 2218381 tgtgatgcaa gtattagcgg ttttgtcatg ttcgtcatcc tttcagggtt tgcttaagaa 2218441 aaaaagatac tcgtttatcc taccaaatca cgaggcttgt cacaatttca gaaaaataac 2218501 tttttcatga caaaataaaa aaagcctgtc actaaaggac gaaggctcag ggcactatct 2218561 cttattttac gacggctaac agctcctgct gagccttcca cccggcttca gcacttggat 2218621 cctctaattc ctttaaagcc tgcaaaatcg cttttttctc tcctgtttct gacgcttttg 2218681 tttcaccaag cgacttttct attttctcta cactcgcttt tgtaatgtct tcgtcgagaa 2218741 tcgcctttgc tgcaagctcc gctgtttcct taaaagaatc tgtcatatct gactctattg 2218801 ataaggaaag ctccttgcct ccccaggctt caaaatcact gtcgattaaa acctgtccta 2218861 actgctgtga gacctccttt tcacttgcta agcctgcaat aacatacgta tacccgtcat 2218921 cctttgacag tgacacggcg gaatatcctt tttcggtcaa ttgttctgtt aacgtttcgg 2218981 cgcccttttc atttgaaaat tttccggctt gcacagcgta tgttttgtat gtaccttcag 2219041 tttgtgccgc ttgtttttct gcgcctgagg tttgtttatc agcagaagta tcccctgctt 2219101 ttgccgtttg gctgcctaaa gaatcctcta aagaggccgg tgctgacgct tctttattcc 2219161 ccgatatgtt taacgcgaat aaccctaatc cagtgccaat gacagccgcg aaggcaatcg 2219221 tcgcggccac tctttttacc ggtttggcag ccccggtctt tccttttgcg taaagctttg 2219281 tttttttctt ttgaaaagga ggaacaactt tagggtcctc tttaaacacc ttgtcctcct 2219341 cggaatccca attgaattca tcttcatcag ggtgttcctg ggatgccgca acctcttgtt 2219401 ctgcctgtct tttttcctcc caatttgaaa atgtcatgct tttattcgcc tctgtctcag 2219461 gcgtctcttg ttcgtaaacc gtctcttctt ttccattaat cgtcaccttg agggcttttt 2219521 ctgcggcttt actgtttttt ttattctttc tttttttcaa ttccgcttcc tcccttcatt 2219581 tgcttgaccg ttcttgtcgg cttttcatgc tacacacttt agcacaggca aagaaaaaaa 2219641 gaacaagact tttgtcgcct tgtccaaaaa acgttcgtca aatttttcag cagtcagccc 2219701 aatgccattt tgatataaaa agaaatgata gagtcaccgt ataaataggc taaaatgctc 2219761 cctgcggcta tagcgggggc gaagggaagc ggctgccttt tagcgagtct accagtcaga 2219821 acagctgccg ctccatataa tgcacctatc aaaactgaaa agaaaaaggc agctgccagc 2219881 attttcacac caagcacaaa gccaatcacc gcaaataatt taatatctcc tccccctact 2219941 cccccatggg tgattgcggc aattacagcc agaaacaaaa atccggctgc cgcacctaac 2220001 aggcctgcat accaggaatc aagcggagaa atcaatctcg cggccgccaa aaagggaaga 2220061 aagaaaatca atattcgatt tggaatcagc ataaaatgaa tatctgtcac tgcaacaata 2220121 atgagaagag agataaacac cacagcggga aacagttcca gcgatatgcc aaagcgtatt 2220181 cctgcggcgg caaataaaca cgctgtcaca agctctgctg cgggatacat aaaagaaatc 2220241 ctatgcccgc agcttttaca tttacctttt tgaaatagga atgacaggat gggaattaat 2220301 tctgcaggag ttaatgttcg ccggcaaaac gggcatgatg aacggggcgc aataatagat 2220361 agatgtaagg ggatacggca cccggccgta tagtaaaaag aaccaaggat aagcccgaag 2220421 ataaaaagaa tggatagcat agacaacaca cctttactca ttgagttctg gtatggattg 2220481 tagcaaaatg gacatcctga gctccaattg ggaatattca attttacaca tgaaaaaaac 2220541 ggcagaatct ttttttgatt ctgccggagc cggatgcttt tatttcaacc tttttcgaat 2220601 gtcagaaata aagtaaagag atccggtaat cagcacaatt tcatttgagc cctttttact 2220661 ttctatgaat ttgattacat cgtctggatc ttcactccag cttttattgc tgatttcact 2220721 tgcatcatag agatcttttg caagggaagc acgcgggaaa tcaaaagaag caaaatgaat 2220781 cgcatgagca atggtttcca gtcttttaat catgttctga tacggtttgt cctttaacgc 2220841 gctaaacacc acagaaatgc gtgaattggc gaaacgctgc ttcatcgttt ccgccagctt 2220901 ttcaacacct tcttcgttat gcgcaccgtc taaatatacc ggaggatgtt cctgaacaag 2220961 ctctaaccgt cccggccaag cagccttcac aagcccgctc cttaacgctt cgtcactgat 2221021 atgggcgata ttctccttat tgagccactc cgcagccaaa atggacaaag cagcattttg 2221081 tctttgatgg gtgccaatca gagatgtccg aatatcttca tagcatttct cttccgtttt 2221141 gaatgaaaac tgttctcctg caggcagagc ctcttcattg aaaataacac atgcatcatg 2221201 caatgactgg aacggcgcag catgccgttc ggcttcatgg cggatgacct gtaaagcttc 2221261 cggctgggta actgctgtaa cgattggaat accttcttta ataatgccgg ccttttctcc 2221321 tgcaatttct tcaatggtgt ttcccaaaat gttcatatga tcgtgtccga tgcttgtaat 2221381 cacagttaag agcggttcaa ccacattagt agaatcgaat ctaccgccca gacctgtttc 2221441 aaaaataaca aaatcgacct tatgaaactc tgcaaaatat aaaaatgcac aagctgtcat 2221501 aatttcaaat tctgtcggct gtccgtattc cgtttgatca agggcttcaa cgtgcggttt 2221561 catttgattg acgagtgctg tccattcctc atctgaaatc ggtatcccgt ttacgctgat 2221621 ccgttcatta aacgtaataa tataaggcga tgtaaatgtt ccaaccgtat atccggcttc 2221681 ctgcagcata gaacggataa aagcgacagt tgatccttta ccgtttgttc ctgcgacgtg 2221741 gaacgctcgg attttttttt caggatgtcc taaccgcgcc atcagctgtt tcattcgacc 2221801 aagtccgggc ttcaccccga atttcagcct cccgtgaatc cagctgcgcg catcttgata 2221861 tgcagtaaac aatgataatc ccctctttta taagacaagg cggtttctct agaaaccgcc 2221921 ccggcttttc attaaccctt cagctcagcc attcgttttt gaacagcgtc acgcttcgcc 2221981 acataatctt tttctttttc acgttcttca tcaattacgt gtgcaggcgc ttttttcata 2222041 aatccttcat ttccaagttt cttttggaca cgctcaactt cttttgtcag tttatcaaat 2222101 tctttttgca gacgggcaat ttcttcatca atattgatta agccttcaag cggaagaata 2222161 acctctgctc ctgagacaac ggccgtcatc gccttatcaa cagcctcaat atcggtgccg 2222221 attttaagca cgctcggatt cgtaaagcgt tcaacatatg aacggttcgc ttcgaggcgg 2222281 gacgctattt cgtctgtgct tgttttaatg tacagttcaa cctgcttgct cattggcgta 2222341 ttgacttcac tgcggatatt gcgcacagaa cggatcagct caacaagaag cttcatgtca 2222401 gctgccgctt cagtatcggt atgctccggc actactgcag gccattgact tactgtaatc 2222461 gattcccctt ggtgaggaag gtgctgccaa atttcctccg ttaagaatgg cataaacgga 2222521 tggagcagac gcatcgtttg atcaagtacg taagcaagga tggaacgggt agttttctta 2222581 gccgcttcgt cttctccata aagcggaagc ttcgccattt caatatacca atcacagaaa 2222641 tcatcccaaa taaagttata taaatggcgt cctacttcac caaattcata tcggtcagca 2222701 agctgggtca cgtgctcgat cgtttcattt aatcgcgtta aaatccactt gtcagcgact 2222761 gacttttcac ctgacagatc aagctcatcg tacgtcatgc catccatatt cattaatgca 2222821 aaacgggagg cgttccaaat tttattggca aaattccagg tcgattccac tttttcatag 2222881 ctgaagcgca gatcctggcc aggagagctt ccagtcgcaa ggaaataacg cagagaatcg 2222941 gctccgtact tgtcaatcac atccatcggg tcgacaccgt tgccaagaga tttactcatt 2223001 ttccggcctt gctcgtcacg gattaagccg tggattaaaa catctttgaa cgggcgctcg 2223061 cctgtaaatt caatgccttg gaaaatcatg cgtgataccc agaagaaaat gatatcgtac 2223121 cctgtcacga gaacatctgt cggatagtag cgtttaaagt cttcagccgt tacatcaggc 2223181 cagcccattg tggagaaagg ccatagcgca gaactgaacc atgtatccag tacgtctgta 2223241 tcctgttccc aattttcgct gtcttccggc gcttcaagtc cgacatatag ctcgcctgtt 2223301 tctttatgat accaggcagg aatacgatgg ccccaccaca attgacggga gatacaccag 2223361 tcgcggatat tttccatcca gtgtaaatac gttttttcga aacggtcagg cacaaagttg 2223421 accttttctt cttttttttg cagctcaatc gctgcatcag caagcggctg catgcgcaca 2223481 aaccattgtg tagaaagata aggctccaca acagccccgc ttcgttcact atggccgaca 2223541 gagtgcatat gatcctcgat cttgaagaga actcccgcct cctgtaaatc tttcacgagc 2223601 tttttgcggc attcaaaacg atccatacct tgatattgga gcgcattttc attcatcgtg 2223661 ccatcttcat tcatgacaag gatgcgttct aaattgtggc ggttgccaag ctcgaagtcg 2223721 ttcggatcat gagcaggcgt aattttcacg gcacctgaac caaattccat atcaacatag 2223781 tcatcaccga caatcggaat ttcacgattt acaatcggca ggatcaccgt ttttccgata 2223841 aggtgtttat agcgctcgtc ttcagggtga acggcaacag ctgtatcacc gagcattgtt 2223901 tcaggacgtg tcgtcgcaat ttcaattgag cctgaaccgt cagcaagcgg atagctcata 2223961 tgatagaatg cgccttgaac atccttgtaa atcacctcaa tgtcggatag ggctgttttt 2224021 gtcgctgggt cccagttaat aatatattcg cctctgtaga tcaggccttt ttcataaagc 2224081 ttaacgaata cttcccttac cgctttgctc aagccttcat ccagcgtaaa acgttcacgg 2224141 gaataatcta ggccaagacc taatttcgcc cactggctgc gaataaagtc agcatattct 2224201 tccttccact tccacgtttc ttcgaggaat ttttcacggc ctaaatcgta gcgggatttg 2224261 ccttcttcac gaagtttcgc ctccacttta gcctgtgtcg cgatgccggc gtggtccatg 2224321 ccaggaagcc acagcacatc atagccctgc atgcgtttca ttcttgttac aatgtcttgc 2224381 agcgttgtgt cccatgcgtg gccaaggtga agtctccctg ttacgtttgg cggcgggatg 2224441 acaacagagt atggctcttt tgtctggtca ctgcccgctt caaaaaattt gccttttagc 2224501 caaaaatcat atcggtcttt ttcaaccgct gccggatcat atttcgtcgg cattgtttgt 2224561 tcattcgttt ccatcataac cctccagcat gtttaaaaat ggctgagaac gaaaaaagag 2224621 ctcttcatcc ctgtaaaagg acgaaaagct ctttcgcggt accacctttt ttcatgaact 2224681 caatcagttc atgcacttat aacggataac gggtgtttcc cgaatttctc tactcttctt 2224741 tcaagaaatt atgctcccgg gcgaccttcc aatcagacaa cataagaagc ctttcagcaa 2224801 acggcttctc tctctgcatg cgcctttttt gtactcttcc cgttctaagc aggtgtattt 2224861 atcagctcat tgtatacatt atttatgttc tttattatag taaaagtgtt tttgattcgt 2224921 caatcatctt ttccaaaaac accgctttct atacagatgg gcaggcacct attgcccaag 2224981 tttacatatg atgcttgtaa atgcgtagag gaggatgcac cgtgaagaaa cgtttcagct 2225041 cttattcgct gccgccatgg gtaaggcaaa ttcggcttgt atccgcacaa gtgattattc 2225101 ccattacgat ttttcaagga atcagaacca ttttctttcc gacaaccttt gatgttttgc 2225161 tgctcgcaat cctaatcttt ttagcttgcg cccttcattt agaatggata taaacaaaca 2225221 agtccgcgcc attaagacgt ggactcgttt tcagcctgaa attttttctc ttgttcaatc 2225281 tgatgaattt tcatcacaaa cggctctatg tttttcattt gccaataagc ctttaataat 2225341 tgtgtacatt cctctttttc atgctgtctt ttcccagttt gataaccgtt cagcaccttg 2225401 tacatggctg ccggatatgc catatagctg agaaaaaggc tgacttccgc ttcacgcaaa 2225461 gggaatgatt tcgtatatcc ataaaaccat tcgacgcatt ccggacaagc tttcggaaag 2225521 cctctgaaca tttttgtata aaagccgagc aggtcgtttt gcggcggacc gacagatgct 2225581 ctttcgaagt ttgtaaaata tccggtcccg gcatcattat acagaaaatg gtgtatagac 2225641 aggctgccgt ggttcattac aacccttgaa acgtcctttt cctttgcgga ctcataccag 2225701 tcctccagcc gttccagcgc aaagttcacc gcggaaatgg tttcagaaaa ataggttatg 2225761 gcctggagtt caaagggaga aaggtaccat tccttctccg ctctatccac aaactgctca 2225821 tagaaaattt tatcttgttc ccactttttt ttcgtttgcc cgtaataacg ttcaatctca 2225881 tcacgtctaa cctttagttc ctgcgcggtt ctctcgtgaa gacgggctgt ttctctaaat 2225941 aaataagcat gtttttgatc ccgttcttcc tcttggtcaa attggagcca aggcattaaa 2226001 tagtagatat ctccgtattg tatgcctgct gagaaaaact caccgctatt tgttctgtaa 2226061 acgggaacga atgaacgaaa gcctttttcc tcaatcgcca ccatatgatc tgtaaaatgc 2226121 ttgccgcgac cttctttcaa ttttttcagg gcaaatatgc cgtagtctgt atacactttc 2226181 caaacaagag gactgacagg ctcaataaat tgagcagtca gtccgtattc ctgaagaacc 2226241 gattgggtat cttccatttc attcaccaca ttttccgatc acttacggtt tacgcatggc 2226301 tatttttata ttgaggaata tagagaatct gtcctgcttt taattcatca tccaaggcta 2226361 aagaattcat cctgatcagc tgctgggatg taatttcata ccgttcgcat aaacgctcga 2226421 tcgtatcttc ctgctgcaca atacaaattt tcattctcga aaactcatcc gcttcttttg 2226481 taaagagttt tgttaaataa agagaattat cactttcctt tgtttgaggt tccttcgttt 2226541 cagcagcagg agcaacccta ggaacagcat ccgtttcctt cctttcagtc tcagaagatt 2226601 caggcagctg gaaggattga aaaggtgttt cttccttagg ctcttcagct gatggtgttt 2226661 ttctcacttc aatttcgaag ctctcttcct cttgttcttc ctcctccagc agcttaggcg 2226721 ctgaataaaa agaatcctcc tcttcttgtt caggcaggaa ggtacggtat gccggttcag 2226781 gcaattcttc ttgagatgcc tcctccgagc ttgttttttg attgaaatgg aaatgtaaat 2226841 cggcattgtc attctccata tatacagctg aagctgtttc tctgctatct tctatggaga 2226901 gagcggcctc tgatacactc tccaaagctt catccggttc cgcctcttct tggcaaagcg 2226961 caggatcagc ctgatccgat tgagctgctt cttcattttg agcctcttgg cgcagcgcat 2227021 attcatgatt aggagacact gttgtttcct ctttttcctt tgcaatcaca gtctctgaat 2227081 gaagctcagc ttccaaagca ggcgattctt ctgctccaac gtgttcacga agctcagtct 2227141 ccgctggaga gtctgcttct tcacgaacat ccgctattgc agctgccggc tctgccgttt 2227201 ctttttttgc tttaacgatc tcttgaatct ctatttctga aggatcaggt tctggctcag 2227261 attcttctgt ttccgattca gcacgaacct ccgtttccgg cacagcaagc tcttctgact 2227321 cttcttcctc tttcacatct tctctggcct ctggttctga agcaaccgat tcaggcggct 2227381 cagattctgc tttttctgtc tccagttctt cacggagccc cgctttcgag ataaaaagtt 2227441 ctggcggttc ggctggcggt tcatgctgaa gaactgcttc ctctgccgat gatgcacccg 2227501 gttcttctac tacactatgt gccggcggct ctgaaagctc ttcctccctg aatgccgcag 2227561 gagcttcata taaaggtatc tccggctctt tgtcttgcgt atcgtccaaa agcccttcga 2227621 tcgctaaatc agcttgaatt gttaaaatgc gcgaatccgt caattgatag tcaaatgcgt 2227681 caataaagac gaagacatcc tgtaaatggc tcactttatt tttcggaatg gtaatatcca 2227741 caggaaaaca gtgagtcagt tccgcacttc catcctctct ctttctgact tgttcaacaa 2227801 accgcttatc tgtataaatc tcttcggtat gtttgttttg atctatgttg tactcacctg 2227861 taagttcaag cgatcctatg attgatacat aatcatttac ttcctgaacc ctaatatcag 2227921 gatctaatga aatagaaagc agttcagaaa cttcctgtcc tttttggaaa cagatcgatt 2227981 cttctacaga aaattgcaat cgatgatttt gcggcaagtt catatcctcc tttcatctaa 2228041 tccttaaaat tagatgtcac taaaggtgta tgtatgaact ggagaaaata tgagtgggag 2228101 agcacgaaaa aaccggcaca aggagtcctt gataccggtt ttcactctta tctgcggctg 2228161 atctcagcaa atactttctc agctgcctgg attgtgtttt caatatcttc atcagtatgg 2228221 gccgttgaga ggaaaagacc ttcgaattgt gatggcggaa ggaatacccc ttcatttgcc 2228281 atccctttat aatagcttgc gaacagcttc aaatcagatg atttcgctgt ttcataattg 2228341 atgactggtt cgtttgtaaa gaagaaaccg atcatcgaac ctgcacggtt aaaggtatgc 2228401 ggaatgccat gagccccggc ggtttttgaa attccttctt ccagtctgtc gccttttttg 2228461 atgaaattct tgtaggattc aggtgtcagc tgtttcaatg tctctaagcc agccgtcatc 2228521 gcaagcgggt tgcctgacaa tgtaccagct tgatagatcg gaccgcttgg agcgatctgc 2228581 tccatgattt ctgcctttcc gccataagcg ccgacaggaa gtccgccccc gattactttt 2228641 cctaaacaag tcagatcagg cgttacgccg aagtagcctt gagcgcagtt ataatcgacc 2228701 cggaagccag tcatcacttc atcaaaaatc agcagggagc cgtactgctc agtgatatca 2228761 cgcagaccct gaaggaaacc ttcttgcggc ggaacaacac ccatatttcc ggcaactggc 2228821 tctacaatga ctcccgcaat gtcttcaccg aattgctgga aagcaagctt tacactttct 2228881 aaatcattgt acggaacggt gatggtgttt ttcgcaatgc cttcaggcac ccccgggctg 2228941 tcaggcagac cgagagtggc aacacctgaa ccagctttaa tcaagagaga atcgccgtgt 2229001 ccgtggtagc agccctcaaa ttttaaaatc ttgttgcggc ccgtatagcc ccttgccaaa 2229061 cggagggcac tcattgtagc ctctgttccg gagcttacca ttcgtacaat ttctacagat 2229121 ggcacacgat caatgacgag cttagccagt tcattttcta cttcagtcgg agcaccaaag 2229181 cttgtcccgt attcagccac ttttttgagg ctttctacga cgcggtcatt tgtatgccct 2229241 aaaattaaag gcccccatga caagacgtag tcaatatatt cattcccgtc aatatcaaag 2229301 attttcgagc cttttccgcg ctccataaaa atcgggtcca tgtctaccga tttaaatgcg 2229361 cgaacgggac tgttcacacc gcccggcatg agtttttgcg cttctttaaa agccgttttt 2229421 gatttttcat agcttctcat ctgcctcaac tcctgtcaac tgaataaaat tactccgcaa 2229481 gccatttcgc tgcgtctttc gcatgatacg taataatcag gtcggcaccc gcgcgcttca 2229541 tgcttgtcaa aatttccaac acaatttctt tttctttgat ccagccgttc tgcgctgcag 2229601 ccttcaccat tgaatactct ccgcttacat tataagcgac gagcggcaaa gtaaactcat 2229661 tttttacgtc acgcatgata tccatataag aaagcgaagg tttgacaatc aaaaagtccg 2229721 cgccttcctc aacatctgat tgtgcttcgc ggagtgcctc catacggttg gcagggtcca 2229781 tctgatatgt tttgcggtct ccgaattgcg gtgtgctgtt tgctgcatca cggaacggac 2229841 cgtaaaactc acttgaatat ttaacagcgt aagacatgat gggaatattg acgaatcctt 2229901 ctttatcaag tgcttctctg atcactgtaa caaatccgtc catcatgttt gatggcgcaa 2229961 tgatatccgc acctgctttc gcttggctga cagctgtctg cgccaaaagc tccagcgatt 2230021 catcattgag aatgactccg tctttgacaa gtccgcaatg gccgtggtct gtatattcgc 2230081 acaggcacgt gtcagcgaca acaaccattt cagggaagtg ttctttaatt tctgtgatgg 2230141 ctttttggac aattccgtga tcatggtacg cttgtgttcc gcaatcatct ttttcttccg 2230201 ggatgccgaa cacgataaca gattgaatgc ccagtttgac cagctccgct acttcatcct 2230261 tcaataaatc taatgataca tggtgaacat caggcattga cggaacagct tttttgcctt 2230321 ccagcccttc aacgacaaaa atcggatata taaaatctga tggatgcaaa cgtgtttcct 2230381 ttaccatttc tctcattgct tttgatgtcc gcaggcggcg gtgtctatta aatgattgac 2230441 tcatattctc tcttcctctc ttgacatgct gcacattaac tcaagcatgc catctattgt 2230501 aaatgtatca ggcgtatgcg atgtgatgcc gtacgtcaga agggcatcat ttgttaaagg 2230561 cccaatgctg atacaggccg tcccattcgc cttccacttt tttaattctt ctcccaagac 2230621 atgcataaac gtatgtacgg ttgatgaact cgtaaatgtt acatagtcaa aggaatattg 2230681 acccgcagcg tctttcaatg cctcaatgcc ttcttcatcc ggaatcgttt cgtagagaac 2230741 ccattccttt acttcaaaac cgagcgggac aagctcttgt tttatcacat cacgtgacaa 2230801 attccctttc atcacggtaa tggtctcccc cggttcagca tgctgcttaa gagcgtcagc 2230861 caattgttca gcaatatact cctgtggcat cacatcaacc gatacgttat gcatttttaa 2230921 acggcgcgcg gttttttcac cgacggctgc aattttttta tgcgcaggga gaataagctg 2230981 attttccttc agataagaaa aaaagaagtc tgccccgttc acacttgtaa aaacaagcca 2231041 gcctggcgcg gcaagatcct ctcttacctg ttccgcaaca tcattcggca aagcgcggcg 2231101 aaacgtaatc aaagaggtta aaaccgcttt accgccaagc gcctccactt tttgctgaaa 2231161 tgatgctgcc tgtgccttat tccgggtgac aagcactgtt tttcctttca acggaaaatc 2231221 attttccatc ctcgtcaagc tcccgtttta cacgatcaat taaatctttt gctcctttgt 2231281 cagccataag agcggcacag cgctttccta cttcctccgg atcgtttccg gtgacggttt 2231341 ctttaaaaat gattttgccg tcaggtgaag cgacaagacc tgtcatttca atttcatcct 2231401 gtccatttaa cacggagtag cccgcgatcg gaacctggca gccgccctcc atcgcgttta 2231461 aaaaagcacg ttccgctaag acagtccgtt ttgtatattc atctgtaaac tgagaaaaca 2231521 acgccaacag ctcttcatcc gattctcggc actcaatcgc cagggctccc tgccccacag 2231581 caggcaaaca gcgctcaggc tcaaggaatt cggttacgac atcttgcttc caacccattc 2231641 tggaaaggcc ggcagccgct aaaataattg cgtcataatc ctctgtttcc agcttttgaa 2231701 gtcttgtatc tatattacct ctaatccatt taattgtaag gtcagggcgc tcaatcaaaa 2231761 gctgcgcgct tcttcttaaa ctgcttgtgc caatgacagc acctttcttc atttctgaaa 2231821 gctttacgcg attctttgaa ataagggcat cacgcgggtc ctcccgttca ggaatacagc 2231881 cgatcacaag gccttcaggc aaaacagcag gcatgtcctt catgctgtgc actgccatat 2231941 caatctcttc gtttaaaagc gcctgttcaa tttctttgac aaaaagccct tttccaccca 2232001 cttttgagag tgtaacatcg acaatccggt cgccctttgt cacgatctct ttaatttcaa 2232061 aagcaaacga aggattgatt tccttcagtt tttgaataac ccattttgtt tgagtcatag 2232121 cgagtttgct ccgtctggaa cctactttaa tcgttctcat catttctttc ctcccgaatc 2232181 tgcttgggac atcgtttaac tgaaccaatg gaattgcgac aggcttccaa gcaggaaata 2232241 attgatcatc agcaccagaa aacaagccgt attccacagt gcagcgacct ttccttgcag 2232301 ctccttaatc agcctgatat aaagataata gctgtacagc agcaggacga caaacgaacc 2232361 aagcactttg gcgtcaaacc aatacagcgt ttctagtgag acatacgccc aaatgacgcc 2232421 gagaatcaaa ctcagcagca gcatcggaac cccaatgaca tttaaaacat acgccatata 2232481 atcaagctta gataaatctt ctattctcaa cagccatttt ccccactttt tctttttcag 2232541 cagatgatat tgaaacatat atagcacaga aaaaacgaaa gaaagggaaa aagcgccgta 2232601 tgaaagaatc gccattgtaa tatgaatcac caaaagctcg gatacaagct gcccggaaaa 2232661 agcagctgac tgctgctctg tcggtgaaaa tgtgtgaatg gcgatcatag aaaatcctat 2232721 aacatttgta aaaaacacga taaagtcaac acgtaaaagc tttgtcagta caagtgacag 2232781 cgtgacaagc acccaggcat aaaaataaag tgcctctgtc acatttaata ccggaaaccg 2232841 ccccgtcacc cacataaaat aggccaaata cacggtttgc agagtccaga caatagaaag 2232901 caaccagaag gccatttttc cagccttccg gttgtgttga agaaaatcta taaaataaaa 2232961 gagtacactt aacgcgtaaa tgacgattgt cccctcatta agtcttgcca ttgcagtatc 2233021 aatcattcag ctttcactca cttacaagtg ggctaaagcc cgcttttgat tcagccttct 2233081 taaaagagtg gaccttctgg ctgctttcaa cggttttcat catttgacgg cccgcagctt 2233141 cttcaatatc aaaaatctgc ataaacaacg cgagcttttc ttcagaatca gcatctgccg 2233201 caagctcttt cacctttaaa atcggatcac gaagcatttg gttaataata cttttggtgt 2233261 gtttgttcaa cagttttttc tctcttgtgc ttaagtgagg cagcttacgc tcaatgctgt 2233321 ccatcgtttc tgactggatg gcaagcgcct tttcgcgcaa tgcagaaata acaggcacaa 2233381 caccaagtgt attcatccat tgtttaaatt ccacaatggt ttcttcaatt aacagttcaa 2233441 ctttttcagc tgtttctctc cgctctttca tgttcgcttc tacaatgcct tccagatcgt 2233501 cgatatcata aagaaaaaca ccttcaagat cattcagcgc cggatcaaga tctctaggca 2233561 cggcaatgtc gaccataaac agcggacgtc ccttgcgaag cttattcgcg ttttccatca 2233621 tctctttgga cacgacaaat tcacttgcac cggttgaact gattaaaata tcagcctccg 2233681 caagcgcgct ttcaagctga ttcaagcttc tcgcttcacc tgaaaaacgg tctgcaagct 2233741 ccttcgcttt caagtatgtt cggttaatga cagtgacctt gccgattccc tgtccgtgca 2233801 ggttttccgc agcaagctcg cccatttttc ccgcaccgag aatcaatatg tgcttgcttg 2233861 aaagatttcc gaagattttt ttggcaagtt caactgcagc atagcttact gacaccgcat 2233921 ttgagccaat gtctgtttcg gcgtgagtcc gtttgcccac tgtaactgcc tgcttaaaca 2233981 gctcattaaa aatagtcccg atcgtttttt cttgctgagc tgttttaaag ctgtcgcgta 2234041 cctgtccgag aatctgcgtt tcgccaatca ccatagaatc aagtccgcag gctacacgga 2234101 ataaatgctc aacagcggca tcgctctcat aaaacgttaa gaacggtgac agctcttctt 2234161 tgcttaattg aaaccaatca gctaaaaact tttttatata ataacggccg gtatgaagct 2234221 ggtcgactac cgcataaatt tcagtgcggt tgcaggttga gacaatgatg ttttcaagaa 2234281 tgcttttctc ttctttcagc tgcaccattg cttctgccag ctcattcggc tgaaaactta 2234341 ctttttcacg tatctcaata ggggcggatt tataatctac tcccacaaca agtatatgca 2234401 tcgctctaat tacaccccca acacccaatc ttaatttata atcattctaa catagaactc 2234461 attatttata ataattataa catagtttct ttcacaaaat gtgaacagat tttaaaattc 2234521 ttatgctata ttagaaaaag cttcagggaa aagaagcatt cctattgaca ataccaaaaa 2234581 cagcagaaat ttactacaca tcagctctaa aaaacaagaa ggtgatatgc atgaaacaaa 2234641 aatcaatttt attcccttgt ctgctgcttg ccgcttctgt atatgcatgg ctagaaagcg 2234701 gccaagccga actgttttca gggcaggatc aatggcctgt tctcctcatg ctgttaggcg 2234761 cagcctttgt atatcaagga aaaaaagaag ccgtcacacc ccattttttt atcggtttgc 2234821 ttctcttcgg gatcggttta cacttttttg ccaagccgaa atgggtatgg tggccggatg 2234881 attttgaaat gctcctcttt atgatcggct tctcacttct cgtttcaacc gttcaaaaaa 2234941 aagaatatgt atatgaagct gtgtcgatga tttgtttttc cctgtttttg tactttttca 2235001 aacaaattat ggcatggctt gagtctgcgc atattccaac agcgcttctg aaggagtatt 2235061 ggccgtttgt ctttattgga atcagtttat tgttattatt gataaaacga aaaaaatcta 2235121 tacgataaat aaaaccggta gaggatcctc taccggttta tcattttttt gatcgctccc 2235181 caagcttcgt cttttccctt tttcgtttct gaagaaaaga ggatcagctc gtcttccgga 2235241 tcaatattta atgtttgtcg gacaaccttc gcgtgtttgt cccatttacc tttcgggatc 2235301 ttatccgcct ttgtagcgat aacaataaca ggaatgccgt aatactttaa aaattcatac 2235361 atctgtacat catcattaga tggcgcatgc cgcaaatcaa cgatctgcac cacagctttt 2235421 aattcctcgc gtgtcgtgat ataggtttca atcattctgc cccatgcttc acgctcagac 2235481 tttgacactt tggcaaaacc gtagcccggc acatccacaa aatgcagctc atcattgata 2235541 atgtagaaat taagcgtttg tgtttttccc ggctttgatg acgttctcgc aagatttttg 2235601 cgattgatta atgaattgat aaaagacgat tttcctacgt tcgatcttcc ggccaatgcg 2235661 atttccggaa gccccccttc agggtactgt tccggtttta ctgcactgat cacgatttct 2235721 gactttgtga ctttcatttc ttctctccta ctaaggcatg ttccaaaacc tcgtctaagt 2235781 gggacgccaa tataaatgtc agcccctccc tgacgctttc cggaatatcc tctatatctt 2235841 tttcattatc tttaggcgca ataatggtcg ttaatcccgc tctatgtgcg ccaagcgctt 2235901 tttcctttaa gccgccgatc ggcagcacgc gcccgcgaag cgtgatttcc ccagtcatgc 2235961 cgacttcacg cgaaaccgcc cgtcccgtta aagcagaaac aagcgctgtt gccatcgtaa 2236021 taccggctga cggaccatct tttggcaccg caccctctgg tacatgtata tgaatatcat 2236081 acttctcatg aaagtcaggt tcaatgccaa gttcttctgt tttggatcgc acatagctga 2236141 atgcagcctg agcagactct ctcataacat ctccgagctt tcctgtcagg attaatttcc 2236201 cttttcccgg tgaaagcgat acttcaatcg aaagcgtatc tccgccaacg gttgtatacg 2236261 caagccctgt cactacacca acttgatcct ctgtttcagc ttgtccatat ctgaaaatgc 2236321 gttttccgat aaaatcttga aggttcttct cagtaaccgt aattcgtttt cgctcttcag 2236381 caacaatggc ttttgcagct ttacggcaaa ttgcggcaag ctggcgttca aggcttctta 2236441 cacccgcttc tctcgtatag taacgaataa tatcaagaat cgcctgatca cgcagctgaa 2236501 gattgctttt cttcagcccg tgttctttga tttgctttgg aagcaagtga tcctttacaa 2236561 tttcaagttt ttctatttct gtgtagcctg cgatattaat aatttccatt ctgtctctga 2236621 gcgggcccgg gattgtggcc aaattgttcg ccgttgcgat aaacagcact ttggataaat 2236681 caaaggtttc ttcaatatag tgatcactga agctgctgtt ttgctctgga tcaagcactt 2236741 caagcatagc ggatgatggg tctcctctaa aatcagatga cattttgtca atttcgtcta 2236801 ataagaagac cggattcagc ttgcccgctt ttttcatccc ttgaataata cgtccaggca 2236861 ttgctccgac ataggtccgt ctgtgtccgc gtatctctga ttcatcccga actcctccga 2236921 gtgagattct gacgaatttg cgtcccaagc tttttgcaat tgatttggct aaagacgttt 2236981 ttccgacacc tggaggtcct gccaaacaga gaatcgggcc tttcagggat tttgtcagct 2237041 tctggacagc caaatattct aaaatacgtt cttttacttt ttcaagcccg tggtgctctt 2237101 cgtccaagag acgtcctgct tctttcaaat caagcttatc atctgtttca tccgtccacg 2237161 gaagagcaac cagccagtcg atatagttgc ggatcacaga gctttccgca gaacttgacg 2237221 gaattttttc atatctgttc aattctttaa gcgctgtttc tttcacatga tcaggcatgc 2237281 ctgcttcttc gattttttcc gtcagcgtct gaacttcgcc agttttgcct tctttatcgc 2237341 caagctcttt ttggatcgcc ttcatttgtt cacgcaagta gtattccttc tgcgtacgct 2237401 ccatcgaacg tttgacgcgc tggccgattt ttttctcaat ctccagcact tctttttcat 2237461 tattaataaa atcaatgacc ttgttcagcc tgtctttgac atcagccgtt tctaaaatat 2237521 cctgcttatc ctttagttta aggggcagat gagaagcaac gatgtctgcc attctccccg 2237581 gctcttcgat atcagtaacc gcagcgtacg tttcggccga gattttttta gaaattttta 2237641 tgtactgatc aaagtggtct agcaaagtcc gcatcaatgc ttcgtcttct gtatcttttg 2237701 aatcatcttc atgaataagt tgaatgtcaa ccgacgtgta atcctcgtgt tcattgtatt 2237761 tgacgatatg ggcgcgcttg aggccctcca ccaacacacg aatcgtaccg ttcggaagct 2237821 tcagcatttg cttaattttt gtataggtgc cgacagtgaa aatctcgtct tcaccaggtt 2237881 cgtctatcga aatatcctgc tgagtggcta aaaatatcat atgatcatgc atcattgcct 2237941 gttcaagagc ctgaaccgac ttgtcacgtc ctacatctaa atgcaaaacc atcgtcgggt 2238001 acactaataa acctcttaaa gggaggagcg ggatgctgcg ttttaattct tctgccatgt 2238061 gactgacacc tccgtgactt tagtatgaac cattataata caactttttc atccttgtac 2238121 aataaacggc atggttccat tttctataaa acagtctcct cgtagtatac cctttctttc 2238181 tgatatgaaa aaggaaaaga tgtccttcat gaaaaaaacc ctattatcaa aatagggttt 2238241 aaacggattc tttattgatt tcgatatgaa acggtttttg ttccgttggc ggattcacca 2238301 aaatttcatc aagcacttct tggaacgtct tcactgcaat aatctcgatc ccgtcaatct 2238361 gctttaagat ggcctgctga ttttcatatg ggataatcac ctttttcgca ccggactgct 2238421 tggccgcttt tattttcgga atgacgcctc cgatgggttt cacaagaccg ttcaggctga 2238481 tttcgcccgt catcgcaacg gtattgtcaa taggaatttt gtgtatcgcc gagaaaatcc 2238541 ccgccgccat cgcaatgcct gctgacggcc catcaatcgg aatccctcct gggaaattga 2238601 tgtgaatatc ataatcagaa ggcttcattc ccattgtccg gagcacggtt aatacatttt 2238661 caaccgaacc cttcgccatg ctttttcgcc tgatcgattt tgattggctg ccgatgcttt 2238721 cttcttcagc tattcctgtg atgttaattg atcctttatc ttgagccgcg gttacactta 2238781 cttcgatttc cagaagcgat ccgctgttag gcccatagac tgcaagccca tttacaatgc 2238841 caacctgtgg ttcaacaccg attttttgct cgtgctttgg agtaagctga ctggagtgaa 2238901 tgacccattc aatatcctca atcgtaatgt cctttcgatt ctccgttaca gccatccccg 2238961 ctgcgatttg aatcatattg acggcttccc gcccgttccg cgtgtagctg gtcaaaagat 2239021 ccagtccttc ttcggagata tttttttcaa ttttatccgc tgctgttttg gcaaccgttt 2239081 tcagctcgtc cttttcaagc tcgcggaaaa aaacctccaa acagcgggac cggatagctg 2239141 gcggaatttc gtttggcatt ctcgtggtcg cgccaatcaa gcgaaaatca gccggcagcc 2239201 cattttgaaa aatatcatga atatgattcg gaatttgtgt attttcctca ctgtaatacg 2239261 cactgtctaa aaagactttt ctgtcctcaa gcaccttcag cattttattc atttgaatag 2239321 gatgcagctc ccctatttca tcaataaaca gcacaccgcc atgggcatgg gtgacagctc 2239381 cctgcttcgg ctgcggaatc ccagcctgtc ccatcgctcc ggccccttgg tatatcgggt 2239441 catggacaga gccgatgagc ggatcggcaa ttcctctttc atcaaaacgg gctgttgtcg 2239501 catcgagttc cacaaagaca gcctgctctt taaacggtga ttgtttatgt ttttttgctt 2239561 cttccaacac aagccgcgca gcagccgttt tcccaactcc cggtggccca tagacaatca 2239621 catgctgagg atttggcccg cataaagccg cctttaatgc tttaatgccg tcttcctgtc 2239681 cgacgatatc tttaaagctt ttggggcgga ccttctcaga taatggctcg gacaagctga 2239741 tagcgcgcat tttccgaagc tgctccattt ccttctttga ttctttatct atcgtgacct 2239801 tttgtgtcct ttgattttta agcaaattcc aaaaatacaa accgatgatg atcccaaaaa 2239861 acagctgaat aaataacgcg atccctgtcc aactcatggt ggtccctcct gaaaaacaat 2239921 ttatgtatcc aattcattcc tctgattgct agtatctccc atagaagacg ggaataaacg 2239981 tttttccgga agagttgcat gcaaaaaaac ctcctgagtg ttaccactca ggaggtttgt 2240041 gcttatcttt atgcagatgt tttatcttgg cttacctcag tgccgtcttt taataagagg 2240101 cgaggaggct ctccgtgtgt cacagttgcc ccggtgatta cacatttttc aatgtcatca 2240161 cgagaaggca gctcaaacat cacatcaagc atgatgcctt caatgataga acggagtccg 2240221 cgtgctccag tcttgcgttc aattgctttt ttagcaattt cagaaagcgc ttcttcttca 2240281 aactcaagct caacgttgtc aagctcaagc attttcttga attgcttaac aagagcgttt 2240341 ttcggttttg ttaagatcgc aaccaatgct tcttcgtcaa gcttttcaag gcttgcaata 2240401 accggaagac gtccgataaa ttcaggaatt aacccgaaac ggagcaaatc ttctggaagc 2240461 acttttgaaa gaagatcttc tttctcaaga tcagcagctt tattgtcggc accgaatcca 2240521 atcacttttt ggcctaaacg gcgtttgatg atttgttcga taccatcgaa agctccgccg 2240581 caaatgaaca aaatatttgt tgtgtcaatt tgaatgaatt cttgatgagg atgcttacgt 2240641 ccaccttgag gcggtacgct tgccactgta ccctcaagaa ttttaagcaa tgcctgctgt 2240701 acaccctcac ctgacacatc acgtgtgata gacgggtttt cagattttct agccacttta 2240761 tcgatttcat caatatagat aatgcctttt tcggcttttt ccacatcata atcagcagct 2240821 tggatgagct tcaagagaat attctctaca tcttcaccca cgtatccagc ttcagtcaaa 2240881 gatgtagcgt ccgcaatcgc aaacggcaca tttaaaatgc gagccaatgt ttgcgccaga 2240941 agggttttac cgcttcccgt agggccgatt aatgaaatat tactttttga aagctcaaca 2241001 tcatcaactt tgctgttgga gttaatgcgc ttatagtggt tatacacagc aacagcaagt 2241061 gatttcttcg cttgatcttg gccgatgaca tattcattca aaatttcgcg aatttcctga 2241121 ggctttggta cgtctttaaa ttctacttct tcttctgttc cgagttcttc ctctacaatt 2241181 tcagtgcaga gttcgataca ttcgtcacat atatatacac caggtccagc tacaagctta 2241241 cgaacctgat cttgtgtttt tccacagaac gagcatttta attgtccttt ttcctcgtta 2241301 aatttaaaca ttctttcacc ccttaatctt gtctcacttt ttcttttacc ggcagagcaa 2241361 aagaaaatga ttcttgaaac gaacgagtat gtattgcatt ttaccatact ttccaaaaag 2241421 acggtaacaa tgtgtttctg acttgcacat tctatatgta tgacaaaaaa cagccctgca 2241481 ttaactatat tgccccaaga aaaagagata actcataatt gtacaaaaca aggcacgaat 2241541 gattcgcgcc ctgttttatt agtactatta ttatgcacca tattaacggt tttctacaag 2241601 aaaatcaatt gctttgcgaa cttttaaatc ttctttcatc gcgtcagtag aaccgatggc 2241661 ttgtttaata ttttcaacag gcatgttgta tgcttcagcc atttttgtaa gctcagcatc 2241721 aacttcctca tctgatactt caaggttttc cgctttcgca atcgcctcaa gagtcaggtt 2241781 agattttacg cgtttttcag catcttcttt catttgctct ttaagcgcag cttcatcttg 2241841 gcctgagaat tgagtgtaaa gctcaaggtt catgccttgc atttgcagac gctgttcgaa 2241901 ttctttcagc atgcggtcaa gctcagtgtc gaccattgct tgaggcacat cgatttcagc 2241961 attttcagaa gctttcagaa caagctcttc acgcaattta gcgtcagctt cgttttcttt 2242021 tgcttcttct aaacgtttct ttgttttttc agttaattca gcaagtgttt ccacttcttc 2242081 atcgatatct tttgcgaatt catcgtcaag ctcaggaagc tctttcgctt tgatttcgtg 2242141 aattttcact ttaaacacag ctggtttgcc tgcaagatct tcagcgtggt actcctcagg 2242201 gaatgtcact tcaacatcct tctcagcacc tgcttcaagg ccaactaatt gatcttcgaa 2242261 gccagggatg aatgaaccag aacctacttc tagagagtag ttttcagctt ttccgccttc 2242321 gaaagcttcg ccgtcaacga atccttcgaa atcaagaaca actgtgtttc cttcttcaac 2242381 ggcgccttct tcttttacaa caagctcagc ttgacgctct tgaagggctt ttagttcgtt 2242441 ttgaacatct tcgtcagtta cagttgtgtc gtctttttca atgcccaggc ctttgtattc 2242501 gccaagcttc acttcaggtt ttactgttac tttcgcagtg aagattaagc tttcgccttt 2242561 ttcgattttt tcaacatcga tttcaggacg gtctacaggc tcgattccag cttcttcaac 2242621 cgctttaggg tattctacag gaagaagaat atccaaagca tcttggtaaa gagcttctac 2242681 gccaaagcgc tgttcgaata atccgcgagg aattttacct ttacggaatc caggaattga 2242741 aacttgtttt actacttttt taaatgcatc atcaagtgct gttttaaacg tttcagcatc 2242801 aacttcaacc gttaaaacgc cttcgttgcc ttcttgtttt tcccatttta cagacatgtg 2242861 tttccctcca aaaatctatt caggttgtgt cggtcttcca ttctaaagca atcattcggc 2242921 ttcgtccaac aaaaacaaag ctgccaaaga tcagaatcat tatgtataga tgttaataat 2242981 gaactgcaaa gcctgtccaa ccgtatttct tataacccgt tatacacaaa tacaaccact 2243041 atattataac ataacacata gcgctttcaa ctatatggcg cgatttacaa ataagaaatt 2243101 tcttcaatat cttttaacat tgtgcaagct tcatcgagtt ctctgtctgt aaattcatac 2243161 atcatatgaa gttcttcgct ttcaatttca atcccgtgca tctcgtaacc gactttatga 2243221 agggcagccg cccaaaggtc agccgacagc aatttcggct ggaacggata taaaacgtac 2243281 aaatgtcttc tccacaattc ttctactgct gcatataagg ttggattttc atttccaagt 2243341 gtctcatcta gcaccctgag aacacggtga agaatcggcg cggcatcagg cggaacaatc 2243401 tctgacggtt caattgtcaa cgactcgcca aatttactaa tgtgtacagg tttactgtac 2243461 tcatgctcag ccaacagcat gacaatcatc gttttgataa tcggatgggc tgaggggtct 2243521 tggaggattg ttttgagcaa tcctgtatac tttgctacgt tacggtcttt taaggaatga 2243581 atgagattca tttgctcctc agggcttgcc agcactttct cggtgtcaat tgtatcctca 2243641 tattcttcgg cccaagcctc gtcctcacga tccggatcgg tcattttccg gctgaaatcc 2243701 agcagcttat aaaattgctc ggcactttct gccggcagct gattttcttc caaaacggct 2243761 tcaatggtgc ttttgacttc ttcgtacttt ttgagctgaa ttaagatggt catgtacacc 2243821 tgcaaaaccg taaaataatg gccataacct tctttgagca tcttctcgca cacgctttct 2243881 gcctcttcca gctcgcccag ctctaaaaag cagatggcca tccctaagtg aagatcggat 2243941 tcagtatcat catatttcat cgcttctgaa aacagttcaa gcgcttcttg atactttttt 2244001 tccttgagtg atgacatccc tttttccaca aggcggtctt tcagatgagg aaaaggaata 2244061 atttttgcgt ttttcttgtc atgcgtcata cctatattcc tttcaggcat ttattttgtt 2244121 caagtgtatc aacacctgtg aacaaaaaca agaaatgaaa ggtttcacca ggcaaaaaaa 2244181 gccgccggac aaataccggc cgctttttca ggcttgaagc caagagcttc tttgtgattc 2244241 aaattgcttg atttcatctt ccagcagcag cgttaatgaa atttcatcat atccgttgat 2244301 cagcatctct ttccaatgcg gatcaacttc aaatgaaatt tgattgcctt cactgtcatg 2244361 aatcagctga ttttcaaggt caacagtcat ttgcaatgac tggttttcat actggccgac 2244421 aagctgtttc caattgtcat atggcatgcg gatcggaagc atgccgtttt taaagcagtt 2244481 ctgatggaaa atatcagcga atgacggcgc aatgataatt ttaaacccat aatcatcaag 2244541 tgcccacgga gcgtgttcac gcgatgaccc gcagccgaag ttttctcctg ctattaaaat 2244601 ggaagctcct tgataaacag gctggtttaa ttcaaattca gggttcggtt caccattcgc 2244661 atcatatctc cagtcaaaga atgcaaaacg tccgtagcct gttctttcaa tcctcttcaa 2244721 aaattgctta ggaataatct ggtctgtatc cacattgatc cgatttaata cggctgcttt 2244781 ccccgtatgt gatttcaaag gttccatctc gcgcactcct tacacaactg ttttttcctg 2244841 ataaaacttt ctgacatcaa cgaagtgtcc gtgaatggca gccatcgcag ccattgccgg 2244901 gctgacgaga tgtgttcttg caccttttcc ttgtctgccc tcgaagttgc ggttagaggt 2244961 tgatgcacag cgctctccct caggaacaac atcattattc atactcaaac acatgctgca 2245021 gcctgactct ctccattcaa atccagcttc caagaaaatc tggtcaagcc cttctttttc 2245081 agcctgaagc ttcacgcttt gggatccggg cacgacgatg gcccttacgc tgtcagctac 2245141 cttcttccct ttgatcatgt cagcagcctg tcgaaggtca gtcatgcggg aatttgtgca 2245201 ggaaccgata aatacgtgct ccactttaat gtcttcaatt ttttggtgag gagtcaatcc 2245261 catatattca taagcacgaa tcgcttcttt tttatcgtct tctgcagaaa agctttccgg 2245321 cgcaggaact tcagaatcga caggaagaac cattcccggg ttaatgcccc atgtcaccat 2245381 aggggaaatt ttgttgccgt caaggacgat agatttatcg taaacagcgc ccgggtctgt 2245441 gcgcagcgcc ttccattcct ctacggcctt gtcaaattct tcgccttttg gcgtgtactt 2245501 gcgatttttg caatattcaa acgtcacctc gtcaggtgca atcaaacctg ctcttgctcc 2245561 tgcttcaatt gacatgttac aaacagtcat tcgttcatcc atcgtcatat ttctgaatac 2245621 ttccccagtg tattcaatga cgtagcctgt gccgaatttc acaccgtatt tgccgatgac 2245681 agcaaggatg acatcctttg ccgttacccc tttttgaagc gttccatcta cgcgcacttc 2245741 aagtgttttt ggacgctgct gccaaagtgt ctgtgtggaa aggacatgtt caacttcact 2245801 cgtcccgatt ccaaatgcaa gagcgccgaa agcgccatgt gttgatgtat gactgtcacc 2245861 gcacacaatc gttttccctg gaagcgttaa gcctagttca ggtccgacga catggacaat 2245921 cccttgatcc acactgtgaa gatcggcaag gcgcacgcca aattcctcac agtttctttc 2245981 aagcgccgtt acctggcgtt tcgcaacttc atcctttatc tcaaaacgat tgacagtcgg 2246041 gatgttgtgg tccattgtcg caaatgtgtt ttggggtctt ctgacctttc ttcccttttg 2246101 tctcaagcct tcaaatgcct gaggagacgt cacctcatga atgaggtgca aatcaatata 2246161 gagaagatcc ggctttccct caccatgttt tacaatatgc tgatcccaaa tcttttcgat 2246221 gattgttcga ggcatcatct tttatttcct ccctctacct agagctaaga ccgcttaacg 2246281 taagctgtca cacattagaa attgtatttt cactcatgat tgctgcctta acttcctctg 2246341 taatggcctg agtgctgctg aactcttcac tccgtgccaa gtctcttgtt ctttttccag 2246401 aagccaagac tttgtttacc gcatcttcta cagctttcgc ttcctcttca agcccgaaag 2246461 atgttctcaa aagcattgcc gctgacaata tggctgcgaa cggatttgcc atccctttac 2246521 cggcaatatc aggcgcggag ccatgaacag gttcaaacag atgaaggcca gagcttgata 2246581 ggctggctga cgggagcatt ccgagcgagc ctgtaagcat ggacgcttca tcgcttaaaa 2246641 tatcaccgaa catattttca gtcaccacga catcaaattg attcggtgca taaattagct 2246701 gcatggccgc gttatccaca agcatgtgct caagcttcac atcaggaaat tcttgtgcaa 2246761 cgtcctcagc cacttcacgc cacagccggc ttgattcaag aacattcgct ttatctacag 2246821 aggtcacttt gccttttctg gctgccgcca ttttgaagcc ctctctgatc actcgttcaa 2246881 tttccgttcg cttataaaac agtgtatcta ctgcttcctg ctcaccttca gtgtttacat 2246941 aacgtttgct cggctggccg aaatacaagc cgcctgtgag ctcacgaacg ataacgaaat 2247001 caacattatc tatatattct tttttcaaag gcgaagcgtc agaaaggctt tcaaatacct 2247061 tcacaggccg caaattcgca aacaaatcaa gctgttttct gatgctgagc agcccttttt 2247121 ccggtctcag ttccgaagga ttttgatccc atttcggtcc gccgacagca ccaagcaata 2247181 tcgcgtctgc atttttacaa gcagcaacgg tttcctccgg gagggggtta tgatgttcat 2247241 caatagccgc ccctccaatc aggccatatt caaattcaaa ttcatggtta aagcgttcgg 2247301 caacactttt cagtacgtct gtcgctgatt ctaatacttc agggccgatc ccgtctccgg 2247361 gcaatagagc aatacgtttc ttcaagttaa ccgttctcct ttcttttatg atccgacagc 2247421 tgtgtggttt ttcaatccgc tcatattcga ctggaaaacc aattgacggt ttactgcgtt 2247481 caaataggct ttcgctgatg cttctaatac gtcttgcgct atgccccgcc ctgctgattc 2247541 ttttccgttc accaaaactc ttacatacac ctgggcaaat gcatcttcgc cttttctatt 2247601 agactgaatg cggtagtcta agagctccac atccttatcg atgcagcgct caagcgtatt 2247661 gtagattgct tccacgcttc cagctccagt tgcagcttcc tgaataagct gtgcgttttc 2247721 ttgatttttc aaagatagag tagccgtagg gacctgactt gttccgtaat gtacttgcag 2247781 agaaagaaat tcatacccaa tcttgcgatc tgttactttt tcttctaaaa taagagaaac 2247841 aagatcctca tcagtgattt cttttttctt ctcagtcaac tctttgaaca tcgtaaagaa 2247901 tttattaatc tcttcactgt caaattggaa tcctaaagca gtcagccggt ctttaaatgc 2247961 gtggcgtccg gaatgtttac ctaggacaag cgcatctgcg gttacgccga caagctccgg 2248021 tgaaataatt tcataagtcg atttttcctt taaaaagccg tcctgatgga tgcctgattc 2248081 atgagcaaat gcattatctc caacaaccgc tttgttgcgc gggacagcca tgcctgtcag 2248141 tttgcttact aaatcacttg ttctcttaat ctcgttcagc gtaatacctg tttcgacttg 2248201 gtagaaatct tttctggtat ggagggctac ggcaatttcc tctaatgccg cgtttccggc 2248261 tctttcaccg atcccgttca cagcgcattc gatttgatca gcgccatttt caatcgcagc 2248321 aagagagttt gcgactgcca ttcccaaatc atcatgacag tgggctgaaa gctttgcttt 2248381 gtgaatgttc ggaacgtttt ctttcatata tttaaagata tttccgtatt ccgccggggc 2248441 caggtagccg acagtgtccg gaagattgat aacactggcg cctgcgtcaa tcactttctc 2248501 gacgatttct gctagaaacg gcagttcagt gcggcaggca tcttcagctg accattgcac 2248561 aatcggaaaa cgttcttttg cgtatttcac cattccaact gctctttcaa tgacttgttc 2248621 acgtgtcatt ttcagcttgt gcttcaaatg aatgtccgat gtcgcgataa atacatgaat 2248681 tcttggttga gcgccatcct ttaacgcttc ccaagcagca tcaatatcac cttttacaca 2248741 acgggccaga ccagttactg aacaattttt aatggttctt gcgatttcct gaacagctaa 2248801 aaagtcacct cgggacgaag cgggaaatcc cgcttcaatg atgtctgccc cgagtctttc 2248861 gagctgctta gctatggcaa gtttctcctg tgtattcaag ttcactccag gggactgttc 2248921 accatcacga agcgtcgtat cgaaaaaatt aattttgcgc aacggagacc accgcttcct 2248981 tcttcttgcc ttgtttcaca aacggcatca tttcacgaag ctttcttccc actacttcga 2249041 tttgatgttc gttctcgctt gcattgatag cgttgaaacg aggacggttt acttggtttt 2249101 cgacgatcca ctcttttgcg aatgtaccgt tttggatatc ttttaatact tctttcatag 2249161 attcttttac tttggcgtcc acaacgcgag ggcctgatac gaaatctccc cactgtgctg 2249221 tgtcagagat tgaatatctc attcctgcaa gtccttcttc gtacataagg tctacgatta 2249281 atttcagctc atgaagacac tcgaagtatg caagttcagg ctgataacct gcttcagtta 2249341 aggtttcaaa tccggctttg acaagcgcgc ttaatccgcc gcaaagaact gcttgctcac 2249401 cgaacaaatc tgtttctgtt tcttctttaa atgtcgtttc taatacgccc gctcttgcgc 2249461 cgccgattcc tttagcataa gcgagggctt tgtctcttgc ttctccagtc acatcttgat 2249521 agattgcgaa caatgcaggt acgccagctc cttgctcata tgttcttctt accaagtgtc 2249581 ccgggccttt aggggccact aagaatacat ctacatccgc cggaggaaca atttgatgga 2249641 aatgcacgtt aaatccatga gcgaatacta atgattttcc tgctgtcaat tcatctttga 2249701 tttcagcttc gtatactttt tgctgctgct catccggaag cagaaccatg atgatttcgg 2249761 cttgggctgc cgcttctttt actgaaaata ctttatgtcc gtcttcttgg gcttgagtga 2249821 aagattttcc ttgtctaaca ccgacgatca cgtctactcc gctttcttta aggttcaggg 2249881 catgtgcgtg gccttgcgaa ccgtacccga taaccgctac tgtttttcca gccaatacgt 2249941 tctctttgat atcaccgtta taatatactt ttaccatttc aatctctccc ttgttatgtt 2250001 ttatacaata gatattgttt tattggatga cgccttttgc tgggttcccc tcgcaaaagc 2250061 cgttgtacct gttctcgcga tttctttaat gccataaggt tttaataact caataagcgc 2250121 ttcaattttg ttagattcac ctgtcacctg aacaacgatg ctgtctctgc tgacatcaac 2250181 gacagaggct ctaaacggtt ctatgattcc attaatctct gttcttgttg aaggtgcgga 2250241 gacaaccttg attaaggcca gctccctctg gacaatcgat tgatttgtga tgtctgtgac 2250301 tttcagcaca tcaatctgtt tgttgagctg tttcgttaac tgttcaacat cattttcacc 2250361 ttcaacatga acgacgaagg tgattctgga aacgccggct gtttctgtgt gtccaactgt 2250421 aatgctttca atgttgtaat gcctttttgt gaatagaccg gtgatccggt ttaacacccc 2250481 ggagcggttc accacagtca atgtgataat tcttttcaag gtttcacccc caccatttca 2250541 tgcagccctt tccccggagc caccatcggg aatacttttt cttcgctggc aacccgcacg 2250601 tcaatgacaa caggttctct tgatgttaat gcctcttcca gcttttcctt tgcttccgct 2250661 tctgatgaaa ttctgatgcc tttaatgccg tatgcttcgg acaatttgac gaagtcaggc 2250721 tgagaagcga atttagattc tgaataacgt tcttcataga aaatttcctg ccactgtctg 2250781 accattccga gacaagcgtt atttaaaatc actaccttga ccggaagatt taattcgcga 2250841 ataacatcga gttcttgaag cgtcatttgg aatccgccgt ctccgacaac cgcgacaaca 2250901 gtagcatctt tttcggccag ctgtgcgccg atcgccgccg gaagaccgaa tcccatcgtt 2250961 ccaagtccgc ctgacgtgac ccatttatct gctttttgga acggataaaa ttgcgctgac 2251021 cacatttgat gctggcctac atccgttgcg acaatggcct ctccttttgt aaattgatga 2251081 atatattcaa tcaatttctg aggtttaaaa ccttcttctt cattatctac ataccagagc 2251141 ggatactctt ctttccattc tgcgagctgt tttttccatt cgcttgaatc gctttgtttg 2251201 ccgtcttgtt tgatcagctc ctgcaggaca attttgctgt ctccgactac aggaatctgt 2251261 gttttcatga tttttccgat ttcagctgga tcaatatcga tgtgggctat ctttgcgttt 2251321 ctggcaaagt gtttcaggtt tcctgtgaca cggtcatcaa aacgggcgcc gatactgatt 2251381 aatagatcac attcatgaag ggccatattg gctgtataag taccgtgcat tcccgccatc 2251441 cctaggaaaa gcggatggtc agccgggaag cctccgagcc ccaaaagggt gtgtgccaca 2251501 gggatttgct gctgttcagc ataatttttt aattcttctg acgcttttcc gtgcagtacg 2251561 cccgcacccg ccaggatcac cggttttttc gcactgctca cggcttccac aagcttgcgg 2251621 atctgcaaat aattcggctc tgttgtcggc tggtatcccg ggagattcat ctcatgatcg 2251681 tagctgaatt ctccttcaat tgttgctaca tctttcggaa tatcaatcaa tacaggtccg 2251741 ggtcttccag ttgttgcaat atggaacgct tctttaatga tgcgcggcag atcttccggc 2251801 tggcgaacct ggtagctgtg ttttgttact ggcatcgtaa tccctaaaat gtctgcttcc 2251861 tgaaatgcat cgctcccgat tacagaggtt gctacctgcc ctgtaaagac gactaacggc 2251921 aatgaatcaa tcatggcatc agcaaggcct gtaacaaggt ttgtcgctcc cggccctgac 2251981 gtggcaatga cgacacccgg ttttccggag acccttgcgt atccctccgc tgcatgaatt 2252041 gctccttgtt cgtgacgggg aaggatatgt accaaccctg aattgtatag cttatcgtaa 2252101 atcggaagca cagccccgcc cggataaccg aagatcattt ctactttctc tttttttaat 2252161 gattcaatca gcattaatgc tccgctcatc gtctgtgtac attcggcaga tgctgaatcc 2252221 acctgtacat tagtccccat tttagttcct ccttttggat tttcatcctt taaagatcat 2252281 cttttcatta gctagatagc tgattattca ataaaaaaag cccttccgcc cacaatcagc 2252341 cgcgcagtaa ctgcgatagc taaaaggggc gaaaaggctt ttctttccgc ggtaccaccc 2252401 ttgtttacgg cctgttaatc ggccgtctca tggatatttc tatccgcttt agtaacgagt 2252461 gaatcaagtt cacccggcca agtcctactg tcatttcaga ctggcactct gaggcgagtt 2252521 caccttgtaa agcttcgccg gttctcagct aacccggttc tctgtggaaa actttatcaa 2252581 ggctacttat cctcatctgc gcttttcata ttcagccttc ggaacggctt tccagctgtt 2252641 caagaaggtc gtttgttttt cattttttta gaatcatact gcgatgattt tcgcttgtga 2252701 agcttgcatt tatcttttgt tgaactcata ttacgccgct ttggacgcag tgtcaacagc 2252761 attttttaaa attattagac aattttgatt aatcaatcta tattgtatac gctttcatta 2252821 ttggtacaaa aggaattgca aatgttaaaa gtttttataa tttttttatt aatctatcaa 2252881 gaatacacca gaattattta attttatata aacatggaag attttataac acgatatggt 2252941 tcgtatatgg attgagtctg acagatcatc ttgcaatcca tttcaatttc ggataggcac 2253001 ttctcttgtt ccctcggcat acattaatga tatcttgcaa agaaaaggtg atacgatgaa 2253061 taaatcattt gcagacatgc aaggatttcc tgcgggcttt ccaagcttcc ccaactttcc 2253121 gcagcagtac tatcctgctg tccctccctt ttaccagcaa agccagcagc catttggagg 2253181 ctacggatac ggacagccgt tcagtcaggc atacagcccg ttaaccactc cctctggaat 2253241 gtactcctca ttcccatacg cttcaggatt ttacggacag caattttcag gtgcaggctt 2253301 tagcggccat ggcggcagct taagtgctcc agcgatacat gccggcggat tcagcggggc 2253361 gccaggcgta cacggaggct ttagatatta aagaatacca caagggccga acatctattg 2253421 cggtcctttt attgttttaa aacgacttca caagtacagt cacattttct gtctttatat 2253481 ttggaaacag gatggaatat gattaagatg aattgaacga tattctgcac aatccgtaag 2253541 ttttcgagga ggaataaaat tgcatataaa aatagacgat ttaactggac gtcaggtggt 2253601 ttcactggtg aatgagcatt tacatagcat gacgcttatg tccccgccag aaagcattca 2253661 tgccttaggt ctagaaaaac taagagggcc tgaaataaca ttttggagcg catgggaagg 2253721 tgatgaacta gctggctgcg gagcgctaaa agaactggac acccggcatg gagaaatcaa 2253781 atcaatgcga acatctgcat cacatttaag aaaaggcgtt gccaaacaag ttctccagca 2253841 catcattgaa gaagccgaga agcgaggcta tgagcggtta agcttagaaa cgggttcaat 2253901 ggcttcattt gagccggcaa gaaaattgta tgaaagcttc ggtttccagt attgtgaacc 2253961 gtttgcagac tacggtgaag atccaaacag tgtgtttatg acgaagaaat tgtgagacgg 2254021 ctttataagg atagataagt gcaggggaag gtctgtctta tctatctttt tttatattca 2254081 cacatttttc acctttatga tacacgccaa tgttttcaat tttgtttaat tcaaagaaca 2254141 gcgggaatta caaacgacat gaacgatatc atgcaaattc ataaaggagg agattgatat 2254201 gaaaagcata gttggtgtat atgaaactcc gcaggaaacc atcgcagcga ttgaaggctt 2254261 acttacaaaa ggctatgatt ctgatgacat ttctgttgtg acaagccggc gagatacaga 2254321 ttatttggag tcacgtacag gaacagaagt caatcaagct atcgatgcac atcaggacga 2254381 atctgaatct tttttcgata aactgaaaga ttatttcaca atggatgata ctgctacaca 2254441 cagcaaagca ttatccgact tggatattaa aactgatgaa atagacaagt atcaagaaga 2254501 tttggatgac ggaaaacttc tggtagccgt cgatacagat gcagatgtaa ttgctcctat 2254561 tgataacggc aatgcccttt caggcggctt ttcaagcaca aatgaattgg attatacaac 2254621 gaaagaagaa aaaacgatgc cgctccggga agaacagctg aaggtcgata aggaagacgt 2254681 tcaaaccggc gaagtagaaa taggaaaaga agtgaaaaca gaaaaaagag atatggacat 2254741 tccggtgaga catgatgaaa tttatgtcga acgccgtcca gtggatgaaa ataaaacgga 2254801 cgctgctccc gtcaacgatt cggaagagat cagagttcca atcgttgagg aaaagctgga 2254861 agtgactaaa aaaccggttg tcactgatga agtggttgtc ggcaaacgca ctgttgaaga 2254921 aaatgaacat atttctgaaa ctgtgaaaaa agaagaacct cgtctgaata aagaaggaaa 2254981 agttgacggc ttggatgatg atccgttaaa taacaaatga aaatcataga ccgacaacaa 2255041 aaaacctcaa atcctaaatg gatttgaggt ttttcttttg gtacgtccca ggagagattc 2255101 gaactcccga ccgacggctt agaaggccgt tgctctatcc agctgagcta ctgggacacg 2255161 ttttgttttt ttgtttttcg ctttaactat cagcgacaag atttattata tatgggatgc 2255221 aataataagt caacggtttt ttagaatttt tttcatgagg aagaaaattt tcttcctcat 2255281 gacattttca tagtgtgact cgattttgca gatcctcaat ttcattgcct gcttggtcgt 2255341 aaaaacggac tgtcgcagca tcattttcta atgtcagtat agcatagctt tctgtcctgc 2255401 gcaccctcgg aagccggatg ctgcctgggt taatcatcag ttttccgcgc agcacttcgc 2255461 ttcccgcgat gtgcgaatgc ccgaagcaga taacatccgc cccgagctcc tctgcacgat 2255521 agtatacgtt taacaaggtc tgttttatac cgtgaaggtg gccgtgtgtg actagtattt 2255581 ttcttgagcc ggcagtcaga agaagctcgt ccttaaaatc gccggcaaaa tcgcaattgc 2255641 cttttacaac cgcataaggc tccaatgcag gatgcctcgt ctcaagctca gagtccccgc 2255701 aatgaatcat gagatcaact tctgcctcat gccgtttcgc aatggtttgg agttcttctt 2255761 caagcccatg gctgtcactg ataatcagca cgttcatgta caagcttcct ccttatgcct 2255821 ccaaaagctt agacagcttt ttaagcgcgt cagccctatg gctgatttta tttttttcat 2255881 cacttgtcag ttcagccatc gtcttatctt tatctttcac gataaaaatt gggtcatagc 2255941 caaagccata ttctcctctc ggttcttcag caatataccc ttcaacatgg ccttcgactg 2256001 tttttgtttc ctctccggga atactcacgg ccagtgcgca gcggaaacgg gcggtgcgct 2256061 gttctttttc gatacctttc agctcgctga gcactttttc gatatttgcc tggtcgtctt 2256121 tctgttcccc tgcatagcgg gctgaataaa ccccgggtct gccgccaaga ttatcgatgg 2256181 atagtccgga gtcatccgca atcaccattt tgttcactgc tttggcaaca gcttccgctt 2256241 tcataatggc attttcttca aatgtatggc ctgtttcttc aatttcctct gtgaatccaa 2256301 tttcagctaa agatttgaca tcatagcctc ttggctcaag aatttctttg aattccttca 2256361 cttttcccgg attatgtgtt gcaataattg cttctttcat gatgatcaag cctttctgtc 2256421 tttatttcag ttctggcaga gaatcaccca gcacttcttt ttgcttgtca atcagctctt 2256481 ggattccttt ttccgcaaga cccagaagac cgttcagatc ctctctagaa aaagttgcct 2256541 cttccccggt tccctgcaat tccacaaaac ggccgctgcc tgtcatgatg acattcatgt 2256601 caacttcagc agaggaatct tcttcataat ttaaatctaa caaaattccc tgttccttat 2256661 caattccaac agagattgca gcaagaaaat cagtgatcgg atttgtcttg attgttcctg 2256721 ctttgatcag cttgccaatc gcaatcgcca tagcaagaaa tgcgcctgta atggaagctg 2256781 ttctagttcc tccatcagct tgaatgacat cacagtcaat ccaaatcgtc cgttcaccga 2256841 gcttttccag atctacaaca gctcgaagcg cgcggccgat caggcgttgg atctccattg 2256901 ttctgccgga aattttcccc ttagaagatt ctctgattgt tctttggttt gttgcccgcg 2256961 gcagcatgct gtactctgct gtaatccagc ctttccctcc gccccgcaaa aacggcggta 2257021 cgcggtcctc aacagacgcg ttgcagatta cctttgtatt tcccgctgtt attagaacag 2257081 aaccttccgg atggctgata aaatccaaat cgaatgtgat tggacgcagc tcatcgtgtt 2257141 gtcttccgtc atgtctcatg ttttacctcc gattgtatgt acataaacca tttttgtccc 2257201 ggaattgaat aaagaaagag gcagccggaa cgctaacctc tttcttccta gtatatcaaa 2257261 aatcccaatt taaaaactac ccgtattcac ttgagatggt ctggagaccg gttctgtgag 2257321 cttttcgcct ttttcattta ccagctctga ttttccgttc actttaacag agacgctttt 2257381 tacatccggc tgctccgtta acgtcagcac aatgctgttc agcacttctg aagaaatcat 2257441 tttcgtcttc tcatcggcgc tgccgaatat agattgattg aaatccaacg tcacgcgccc 2257501 gtctttgatt ttcggtttgc tgaccagctt tacatcttca ctgaagtctg ttaacagccc 2257561 gctcaccttg ctcggccctt tagccaattc attaatggct gctgtgatgt cgtctttttc 2257621 cgaattgtcg attcgtttgg tcaccggcac gtagtattca ctgtcttcat tttccgccaa 2257681 atagtagact gtcagcggat gggtagcagt gagatcattt acaccggctg tttccaaatt 2257741 aatgccgtct ttgcggctta aatcatctga gatcggcgtc cctcctacag gcatctcctt 2257801 cagttcatgc ccgtttattc tcagcttcac tttatctatc gaactaaatt gcgtcagcgt 2257861 ccacgtcaca gattgaacga ttttctgttc gtcttctttc ttataatttt tgaactcatt 2257921 agagaaatca gctatcgccg ttccatcttt tttgatgtca acgttaacgg tggtgtcagc 2257981 cggcaataca gctctgaagc cattcggaag aatttcagac acaggcccgc cctgtacgag 2258041 gtattcaagc gcctgcttag ccgtgctctc acttttagga agaggcagcg tttgcgcaac 2258101 aacatacccg tttttatcaa tgagataaag ctccctcata acagtagatg aggcttgatc 2258161 cgcttttgcg gtatcgcttt tttcactttc tgtttttttg gctgctgttg tatttgaatt 2258221 ggcacccgct tcatcgttca cgaatgtaac gtcttgaggc ggatcaattt cctcggctgc 2258281 cttatcagat tgaaacaaac cgcatccgga taaaagcaag gcagaggtga gacaagtggc 2258341 accaatgact gcaggtcctt ttttcagcat acttttccct cctaaggatg tttgtactat 2258401 tatgtatacg agcctcttta ggaaatagac cgaagaattc cggcaaaaca gaaaaaaacc 2258461 cgcaacatac cgttgcgggg aaaactatct tttaatcggt tcttgcagtg agatacattc 2258521 cacatgcccg acttcatggc caaaccaatc gtctgcgatt tttgcaaact gatcacgcgc 2258581 ccctgttgtc aggaactgat gatccggggc aatcggagac tggttcagca gccctttata 2258641 agagagaatt gtgctgactt cccgggctgt ttcatcgccg gacgaaataa tgtttacgtg 2258701 ctctcccata tatctttgaa tggcttcttt taaaataggg taatgggtgc agcctaaaat 2258761 cagcgaatca attgatgtgt cttttaacgg atacagcgag gttttaacaa tctcgtctgc 2258821 tgttttgtcg agaaacttcc cgctttccac aaaaggcaca agcagcgggc aggcaaggtt 2258881 ttcaaccttc aaatcagggt ttaatgccaa aagcgcttct tcgtatgcat tgctcttaat 2258941 cgtattctct gtgccgatga caccgatatg ctgattatcc gtcactttta tcgctgctct 2259001 cgcaccaggc tggatgactc cgaccaccgg tataccgacg ctgcgctgga tgtcatccaa 2259061 agcgatcgct gttgctgtat tacaggcgat cacgagcatt ttgatgtggt ggttttcgag 2259121 taaataattc gtcagctccc acgtatattg aagcacctct tcttcagggc gcggcccgta 2259181 aggacaccgt ttcgtatccc cgacgtagat aatattttct ttaggtagct gtctcatgat 2259241 ttccttcgca acggttaaac cgccaacccc ggaatcaatg actcctattg gttgttccaa 2259301 caaaatcgcc tcattttctc ttcatttcat gctgcagttt catcaaagat ttttcgaaga 2259361 tggctatttc ttcatctgta aacgattcga acatatcacg cagatattcc tgtctttttg 2259421 taatgacctc ttggataatc cgttctcctt caggcagcag atgtatcctg acaacacgtc 2259481 tgtccgccgg gtccttgacc cgctcaacaa gctcattttt ttgcatgcgg tcgattaagt 2259541 ccgttgtcgt gctgcatgcc agatacattt tgcccgataa ttcaccgatt gtcatatctc 2259601 ctaattcata aagccattgc aagccgacaa attgcggcgg cgtaatcgca tattggttaa 2259661 ggatttctcg tcctttttgc ttaatgatcg cggcaatgtg gcggagtgac ttttcaatat 2259721 ccgcaacatg ctccaaaggt tttgatgtca tttgtccatc cctcactcaa ggatctctta 2259781 cgcacaaaag cgttccgtgt ctattttcct tcttttttga agaaaatgca agactcgcag 2259841 gagagaaata gaggacttta gtcaaacaac atcaagaaat aaaatttaat ttatgacttg 2259901 cctacgtttt gcacagcatt ccaaatatgg tttcgaatgt tccaaacaaa cagcaataac 2259961 cggctccttc caaaagaagg aataccggca aggattaaag ctctagctca cccattctaa 2260021 gaagctcaac aacggcttgc gaacgccctt tcacacccaa tttctgcatg gcatttgaaa 2260081 tatggtttcg aacggttttc tcactgataa atagctcgct tgcaatctcc tttgttgtct 2260141 tatcttgaac gagcaattcg aacacttctc tttctctttt cgttagcagc ggcttcgatt 2260201 gaaattcttt ctccttcaag tattgtaacc ctccttgcta aggtgagagc gaatcagaaa 2260261 cgaatgggtt ttgatatagt cgagatatca tatgtaagaa gggcgcagga ggtgacgttt 2260321 acaagataat tagtttatcg tgtatgaaga agcgtttctt tctcctcatc cgtccagctg 2260381 acagccttgc cgctttcctt tgagacttga accatcacga ctgccccggt gaagcagggt 2260441 tcgccttcga ggttctctcc gagatagtgc aaggtaagag atgaactgcc gactgcgctt 2260501 gttttcacat agatgcgcaa ctcttcataa ggcatgactt ggcgcaaata atcgcattgc 2260561 tggcttgcca cgactgtcat ggtctgtttg ttttcactca tcatattcag ctttttaaaa 2260621 taagaaatcc gcacctcctc aaaatatata aaaggggtta cattattcat atgcccaaac 2260681 atgtctgtct cggaaaatct tacggatacc ttattgaaaa aagaaaagga tgttttccat 2260741 tcttgaaacg gcatatcaat ataagcggga agcttcatct tttttcatct ccttattgtt 2260801 taaaaaaacc tctcccatgc ggaagaggtt ttttcttctt atactctgtc gcttccgaag 2260861 aaattgcgga acgcttgtaa gtttgtatct ctattcaagg ctgcaatcga agtggtaagc 2260921 ggaatcccct tcggacagga ttgaacacag ttttgcgagt tgccgcaatc tgcaaggccg 2260981 ccttcatcca ttaatgcttc taatcgttca gatttattca tggcgcctgt cggatgcgcg 2261041 ttaaacaggc ggacttgcga catcggtgca ggccccatga acttcgattt gctgttcaca 2261101 ttcgggcaag cttcgaggca gacgccgcat gtcatgcatt ttgataattc atatgcccat 2261161 tgacgacgtt tttccggcat tctcggcccc ggtcctaaat cgtacgtacc gtcaatcggt 2261221 atccacgctt ttactttttt caatgaatca aacattctgc tgcgatcaac ctgcaaatca 2261281 cgaacgactg ggaatgtttt cattggtttt aaacggattg gctgttcaag ctggtcaata 2261341 agcgccgtac aagactggcg gggttttccg tttataacca ttgaacatgc gccgcatact 2261401 tcctcaagac agttcatatc ccatgtgaca ggggttgtct tctcaccttt gacattaacc 2261461 ggattccggc ggatttccat cagagcggaa atgacgttca gattcgggcg gtatggaatc 2261521 tcaaattctt catcataagg cgtgctgtca gctgtatctt gacgtgtgat aataaatcgt 2261581 atggtttttt gttcactcat gattatttcg ccaccttctt cttcgagtaa tcccgtttcc 2261641 gaggcgttat cagtgataca tcgacatcct gatactcaaa ttccggcgct tcatacgggc 2261701 ttacatgttt agccattgtt gttttgagcc attcatcatc attacgttca ggataatccg 2261761 gtttataatg ggcgccccgg ctttcattac ggttgtatgc gccaagggta atcaccctcg 2261821 caagctgaag catgttcgag aactggcgtg tgaacatcgc tccctggttg ctccattttg 2261881 tcgtgtcatt gatgttgatc tttttgaagc gctccattaa ctcctgaatt ttgtcatccg 2261941 ttttcaaaag cttgtcatta tggcggacaa ccgttacgtt cgccgtcatc cactcaccga 2262001 gctctttgtg aagaacatag gcattttcgg ttccgtccat actcataata tcagcccatt 2262061 tttcttcttc tttcttaacg tgagcgtcga ataaagatga agacatgtct tccgctgaag 2262121 attctaagcc gtttacatat ttcaccgcat tcggaccggc caccatgcct ccgtaaatcg 2262181 cagacagcag ggagttcgct cccaagcggt tgccgccgtg catagaataa tcacattccc 2262241 cagccgcaaa cagtccaggg atatttgtca tttgatcgta atccacccat aaaccgccca 2262301 tagaataatg gaccgccggg aagattttca ttggaagctt acgcgggtcg tctcccatga 2262361 atttctcata aatctcaatg atgccgccaa gcttaatatc aagctctttc ggatctttat 2262421 gagacagatc gagatatacc atgttttcac cgttaatacc gagcttctgg ttcacacaca 2262481 catcaaatat ttcgcgtgtc gcaatatcac gcggcaccag gtttccgtat gccggatatt 2262541 tttcctccag gaaataccat ggtttgccgt ctttatatgt ccacacgcgc ccgccttcac 2262601 cacgcgctga ttcactcatc agtcttagtt tgtcatcgcc cggtatggct gtcgggtgga 2262661 tttgaatgaa ttctccgttt gcataatacg ctccctgctg ataaacgatt gacgcagcag 2262721 atcctgtatt aatcatggag ttcgttgatt ttccaaagat gattcccggt ccgcccgtcg 2262781 ccataatgac agcgtctgaa cggaaggatt caatttgcat gtttgtcagg ttttgtgcaa 2262841 caattccgcg gcaggttctg tcatcatcta aaacagcgcc aaggaattcc cagccttcgt 2262901 attttgtgac cagacccgca acttcgtatc tgcgcacttg ctcgtccagt gcgtaaagca 2262961 gctgctgtcc cgtcgtcgca ccagcataag cagttctgtg gtgctgtgta cccccgaatc 2263021 ggcggaaatc aagcaggcct tcaggcgtcc ggttaaacat gacgcccatc cggtctaata 2263081 agtggatgat cgaaggcgcc gcttcacaca tcgccttgac cggcggctgg ttggcaagaa 2263141 agtctccccc gtataccgtg tcatcaaaat gttcccacgg agagtcacct tccccttttg 2263201 tattgaccgc tccgtttatg ccgccttgcg cacaaactga atgagaacgt ttgacaggaa 2263261 cgatggaaaa caatttaacc gccattcctg attccgctgc tttaattgtc gccatgaggc 2263321 cggcaagacc cccgccgact acgataatgc ttgattgact catgatagcc cctctccctc 2263381 tagtaatcta gtactcttaa acaaatgcaa aaatcgcttt taagcctacg tatgacagtg 2263441 caacaaaaat aatcagcgta acgtatgtcg aaattctttg agaacgaggc gttaccgtga 2263501 tgccccatgt aacagcgaaa gaccataaac cgttcgagaa gtggaaaatt gttgataaaa 2263561 caccgacaat gtaaaaacca agcatagccg gagagctcaa aatattcgcc atcatgtcga 2263621 aattgacctc agcacccatt tgtgcggcaa tgcgggtttc ccacacgtgc cagctgacga 2263681 aaatgagggt gatgataccg gttacacgct gcaggacgaa tagccagttt ctcatgtagc 2263741 tgtattgacc ggcgttattt ttcgcagtaa acgctatgta cacaccataa actgcatgat 2263801 aaattaatgg taagaagata ataaaaattt ccaaggcata cctgaaaggc aggctatcca 2263861 taaaatgagc agcgctattg aatgcttcag cgccccttgc ggcaaactgg ttgacgacta 2263921 aatgctgaat aagaaagatg ccgaccggta tgacgccaag caaggaatgc aatcttcgaa 2263981 aataaaactc tctgttccca gacattactt taccccctgt ttgataagtg cgaaatgtgc 2264041 taaatctctt cccccacttc tttcaattgt aagcacttta ttaagattta ttgacaattt 2264101 cattttactc ctccctcaaa agggcgtcaa gaaaacgcgt acataaatta taattttccg 2264161 aattgattag ttgattgaaa aattttattt tatcaatata tatttcttgc ttaatttttc 2264221 ataagaatta caggatcatt ctgtaatcct cccccctgtt tgagctataa tatacgcagg 2264281 agagagggga gacagatatg aagtctaaat ttgaagcatc tattgacaac ctaaaagaaa 2264341 ttgaaatgaa cgcttatgcc tacgaactaa tacgagagat cgttctccca gatatgcttg 2264401 gccaagatta ctcttccatg atgtattggg caggaaaaca tctcgcccgt aagtttcctc 2264461 ttgaatcatg ggaggaattt ccggccttct ttgaagaagc gggctgggga accctcacca 2264521 acgtaagcgc taaaaaacag gagcttgaat ttgaacttga agggccgatc atttccaacc 2264581 ggcttaagca tcagaaagaa ccttgctttc agctggaggc tggttttatc gctgaacaaa 2264641 ttcaattgat gaatgatcag attgccgaat catatgaaca agtgaaaaag agagccgata 2264701 aagtggttct gactgtgaaa tgggatatga aagacccagt gtaatcaaaa aggcggtgac 2264761 tgcatagtcc cgcctttttg attgtcatta cacagctgaa gggtgttttg aaagctcaaa 2264821 tgcatcgtga agcgactcga ctgctttcac catgtcattt tcgcttacga ctgttgacac 2264881 tttgatttca gatgtgctga ccattttgat taaaatgttt ttttgcgcca gtacagcaaa 2264941 catttcagcc gctacaccgg gatttgagac catgccggat ccaacaatag atactttagc 2265001 caatttgctt tctgtctcga ttttctcaaa ttccagcgcg tctttatact cttcaagcac 2265061 cgcaacggtt tggtctgcat cttctgtttt gacagagaag gaaattccag tcttgtcctc 2265121 ggcctgcgtt tggataatga tatccacgtt tatgtttctt ttggcaagtg ttgtaaaaat 2265181 agtagacaaa gttgtcaggc cgctagtcag cccgtaaatg gttactcttg tgatttgatc 2265241 ttcaaatgca atgcctctga caattaaatt ctgttccatg gatgattcct cctcaattaa 2265301 tgttcccgct tcggtttctg tacttgaacg cacttctaac ggcacttggt aatttttcgc 2265361 gaactcaact gctctcggat gaagaacacc ggcgcctaaa ttggcaagct caagcatttc 2265421 atcgtatgag atgccctcaa gttttctcgc tgatttcaca tagcgcggat cggttgtaaa 2265481 cacgcctggc acgtctgtgt atatgtcaca tttatcagct tttaaagcgg cagccaaagc 2265541 aactgctgtt gtatctgaac cgccccggcc caatgtcgta atttcacaat cctctgtcat 2265601 gccttggaat cctgcaacaa tgacaatttt tcctttttca agctggtctg ctaaaaccga 2265661 agtgtcgata tctgtaattc tggcgtttcc gtgaatggcc tccgtacgga ttcccgcctg 2265721 ccagccagta taagacacag cgtcatagcc tttttcctgc aatgccattg aaaggagtga 2265781 aatcgtgacc tgctcgcctg tcgccagcag catatccatt tcgcgtttgc tcggctggtc 2265841 agaaatagct tttgcaaggc tgaccaattc gtcagtggat tttcccattg ctgaaacgac 2265901 gacaacgact tgatggcctt tctgtttttc tgcaattgcg cggtttgccg cattttgaat 2265961 tttttcgact gagccgacgg aagtgcctcc gaatttttgt acaataagac ccatgtatta 2266021 ccacccttta cattttggtt cgtgcgggtg aggagaaaga gcgctttgtc cacaataaaa 2266081 aaagcaatga gaggaatact ctcattgctt atcaattaat catcataaat gattatgaac 2266141 aacgagatag ccctccaaga aaatgatttc ttgacagcct tacatttatt caatgcacgg 2266201 ccagcaaata ataccgatgg ggttttattt gcttcggcga cgctcccctt tcagcctttt 2266261 tcacagaatc catctttctc caaaggcata ctcttgaagt tcgcacctct atcttcacca 2266321 tataacacga tctaactatg aaattagttc acattttatc agatcttatt taaaaggaca 2266381 acattatttt tgcaatttgt cgtaaaggag ctgagccgcc gctgcgggaa caccggcttt 2266441 tttgatgtcc tcaaggcttg cttccttcat ttttttaacg gaaccgaaat gctttaacag 2266501 cattttcttt cttttctctc cgatacccgg gatgtcgtcc aaaacggatt gaaacgcgct 2266561 ttttccccgg atttgcctgt gaaaactgat tgcaaaacgg tgcacctcgt cctgaatgcg 2266621 ctgcaggagg taaaattcct ggctgtttcg ttccagatac gccacctcca gcggatcacc 2266681 gatcagtaaa tttgaggttc tgtgtttttc atctttcgct aaaccggcga tcgggatatc 2266741 caagccgagt tcattttcaa tgacatccct tgctgcgttg atctgccctt ttcctccgtc 2266801 aatgataatc agatcgggca gcggcagatt ctcacgaagc actctcgtat agcgtcttct 2266861 gacaacctct ctcatagaac cgtaatcatc cggccctgta acagttttga ttttatattt 2266921 gcggtattcc tttttgtatg gtttgccatc gataaacaca atcatcgcgg aaaccgggtt 2266981 tgtcccctgt atatttgagt tatcaaacgc ttcaattctg tgcggcgtat aaatatttaa 2267041 tgcctcacct agtttctgca ctgccccgat tgaacgctcc tcgtcccgtt cgattaaaga 2267101 gaatttttct ttcaatgcga ttttcgcatt tttatgggca agcatgagca gttctttttt 2267161 cgggcctttt ttcggctggt gaacgtttgt ttccagtagc tgctcgatca tagattgatc 2267221 tatgctgtcc ggaactaaaa tctccttcgg aaggaagtgg ttgttttttg aatagaactg 2267281 cccgatgaac gtgaggaact cttcatctgc ttcctgataa agcgggaaca tgctgacatc 2267341 gcgttcaatg agctttcctt ggcggatgaa aaagacctgc acgcacatcc agcccttatc 2267401 gtacgcgtac gcgaacacat cacggtcgac tagatcgttc atcgtcattt tttgtttttc 2267461 catcgttgat tcaatatggg caatttggtc acgaagctct tttgctcgtt caaactcaag 2267521 attctcagca gcttcatgca ttttctcttc aagctctttt ttgacctcat tatagccgcc 2267581 ccttaagaaa cgtgtaatgc tttcaaccag ctctctgttc gtctcttcgg aaatatcctt 2267641 tacacacgga gcaaggcatt ggcccagatg atagtaaagg cacactctgt ccgggagctt 2267701 ggagcatttt ctgagaggat acagacggtc gagcagtttt tttgtttccc ttgctgcctg 2267761 tacattcgga tacggcccga aatagcgccc tttgtctttt ttgacattgc gggtgacaat 2267821 cagccttggg tggcgttcat gggtgagttt tatgaaagga taggttttgt cgtctttgag 2267881 catgacgttg tatttcggat catgcttttt gatcagattc atttctaaaa taagcgcttc 2267941 aagattggag gacgtcacaa tatattcaaa atcctcgatt tccgtcacaa gcctttgggt 2268001 tttcgcgtcg tgagaaccgg tgaagtagga gcgcactctg tttttcagca cttttgcttt 2268061 ccctacgtag atcacagtct gctgccggtc cttcatgaga taacaacccg gttgatcagg 2268121 aaggagggcg agtttttctt tcagttgttt gttcatatgt tacccttcct tatgtttaat 2268181 cctttatttc cagtttaaca cgaacgtttg tttttctcta tggttcacaa ttggcgaata 2268241 aaaaaagcga tccctcaatc ggaatcgctc tggcatgtaa gcagcggaaa attaaagatg 2268301 tttgtttaca agctcttgaa gcgcttcttt tggtttgaag ccgactgaag tttcaactac 2268361 ttcgccgtct tttaacacaa gaagagtcgg gatgctcata acgccgtatt ttccggcagt 2268421 ttcttggttt tcgtctacat cgatttttac gattttcagt ttgtctccca tttcttgatc 2268481 caattcttca agaacaggtg caatcatttt acaaggtccg caccaaggag cccagaagtc 2268541 tgccagtacg acgccttcgc ttgtttcagc tgagaaagat tgatcagttg cttttacgat 2268601 agccattatt gaattcctcc aatgtgaaat gatgattttt agtatagcat ctcccattcg 2268661 ttcacgctat tttaatgctt acaaattatt ttttcctgat cacagccggt ttactcattt 2268721 ttatatggtt gaatgggata tgctcttttt ttaaaacaca aatctgataa tggccccgat 2268781 cactacaatt gccccaataa tcattaaaat ggtacgaagc ataagatcac atctcctctt 2268841 cactgtcatg tactttacca tgccctgccg gagctgtttt aaaacctgaa aaagagcgcc 2268901 ggcatgaagc tccggcgctc ttgcgcgatt aagaatcagc acgcagcgta agtaagacga 2268961 ctgacattgg cgggagtttt actttcagtt tgtttttgct gagcgtgtat tgtctgaagg 2269021 attccggttt gacatgatga ggatcgtcaa acgtgttatg cgcattcatt ttttctgccg 2269081 taagaatgac tccggaatgg tccgctgcct tgtgtaggcc cctcagctcg atttccgcct 2269141 ctgctttgtt ttggtgatcg atgttgcaaa ttgtgatatt gatatcgcct tcagcttgtt 2269201 tcgacgctga aatgctgatt tgcggaagcg tttcaccgtt ccattcatag tcggcagaca 2269261 ttgtctctgt ggctaaaaga gaagcgtcct ggtgcacctt aaacatattg aatacatggt 2269321 acgtcggtgt caaaagcatc cgctctccct cagtcaaaat catcgcttga agaacattta 2269381 ctgtttgggc gatgttggcc atttgcaccc ggcggcaatg ctgatggaaa atgtggaaat 2269441 gagaagccgc caccagtgca tcacgaatgg tgttttgctg atataagaaa ccgggattcg 2269501 tgcctggctc gggatcaaac cacgtgcccc attcatcaat aatcagcccg acccgctgct 2269561 ccggatcgta ccggtccata atcgtgccgt gtttttgaat caattcatcg atgtatttgg 2269621 cttttttcat cgtaataaac cattcatctt ccgtgaattc tgtggctgat cctttgccct 2269681 tccagaaatc ccccggaatc gtgtaataat gaagactcaa cccgtccatc aggccagcgg 2269741 cttttttcat aagcacgtcc gtccaattaa aatcatccac atttgcgccg cctgcaattt 2269801 tataaatgtc attcccgctg taattgcgga cataagtctg aaaacgccgg tacagatctg 2269861 cgtagtattc gggatgcatg ttgccgccgc agccccagtt ttcattgccc acgccgaaat 2269921 atttcagctt ccaaggctct tctcttccat tttgctttct ccagtctgac atcggcgtgc 2269981 cttcttcaaa tgtcatatac tcaatccact ccgacatttc ctgaacggtt ccgcttccga 2270041 cattgccgca aatatatggc tcgcattcaa gcagctcgca aagcatcata aattcatgcg 2270101 ttccgaattc atttgattca attgtaccgc cccagtgagt gttcagcatt gtcttacggt 2270161 caccgacacc gtttgcccaa tggtattcgt ccgcaaaaca cccgcccggc cacctaagga 2270221 caggaatgtg cagctgtttg agcgcctcca gcacgtcctt tcgtatcccg ttgatattgg 2270281 ggatgtctga gtccgttccg acccagatcc cctcataaat ccctcttcct aaatgctcag 2270341 caaaatgacc gtatatattt ttgttaatgg ttccttttgc gatatctgtt tgaatcactg 2270401 cttgatgttc agacatgcct ctgatcattc ctttcatacg gatatgaaaa gcaccacagt 2270461 caaatatgtg atctgtcgtt tgcctgagga gtcagcatga atgtaagcgc ttttaaagta 2270521 accatattat atatgttcgt acatgtcaac gacattttct attgttttta tatttgtacg 2270581 tatgtattta taaatatgaa aaaacccgga cttttaaagt ccgggatttc ctttatgagt 2270641 gtatattcag ctgtttgaat tcctcagtta ataacgggac aacttcaaat aaatcaccga 2270701 cgatgccgta atccgctatt ttaaagatat cggcttcggg gtctttattg atggcgacga 2270761 tcaccttgct gtttgacatg ccggccaaat gctggatggc gccggaaatg ccgcatgcaa 2270821 tgtacaaatc cggagtaacg actttcccgg tctgcccgat ttggagagca taatcgcaat 2270881 aatcagcgtc acatgccccg cgagaagccc cgactgcggc ccctagcacc tctgcaagct 2270941 cctgcagcgg ctgaaatcct tccttgcttt tgactcctcg gccgcccgca acgataattt 2271001 tcgcttcgga gagatcaaca ccgtccgccg tttttttcac gacctcttgg ataacagtgc 2271061 ggaggtcagt aagagaaaca tcaatgcttt cgatgctccc cgatctgctg gtgtcttttt 2271121 ctgaagcttg aatgttattg gggcgaattg ttgcaaagat catcggatcg gttgaaatga 2271181 cgcgttcaaa agctttcccc gagtaaatcg gccgtgtgaa cacaacattc cctccggtaa 2271241 cgcttacatc tatagcatca gaaattaagc ctgtttgcag acgggcagca agcttcggtg 2271301 aaagatcctt gcccattgcc gtatgcccga agatgactga atcaggattt tcttgctcga 2271361 taacacctct catgacctgg ctgtacccgt ctgccgtgta tgttttcagc ttcgggtcct 2271421 cagcggtaag aactttatct gctccgtaat gaataagctc ttgtgcaatg ctttgtacat 2271481 tttcaccgat gagaacaccg atgacttccc catctcctga aatggttctt cctgcagcta 2271541 ttgcttcaaa ggtgacattt cgcaattccc catcgcgtat ttctccaagc acgatcactt 2271601 tttttcccat tctaacatcc ccctgtttct ttgaatgtcc aagttttaaa tgactttagc 2271661 ttcgctgcgg agcaatgaaa caagctcttt tgcctgttca gcaggctcac cttggagaag 2271721 cttcccggct tcttttttcg gcggcagaaa acgttcaatg gttttcagct ttggttcagc 2271781 atcctcttcg tccagatcaa gatcatcaag ttcaagctct tcaagcggct ttttcttagc 2271841 cttcataatt cccggaagcg atggatagcg cggctcgttt aagccctgct gagctgtgac 2271901 aagcaatggg agcgtcgttt tgattttttc aacatcccct tcgacgtccc tttctgcttc 2271961 tgcatcagtg ccgttgattt cgagtttggt gatcgtagtg atacacggaa tgtccagtag 2272021 ctcggcaagc cgaggcgcca cttgtcctga tcctccgtca atggcaacat ttccgccgag 2272081 aatcaaatca aactcctgat ccttcatata gtggtataaa acttgagaaa tggaatattg 2272141 gtcgggttca tcaagatcat cttctatgtt gattaaaaca gcttggtcac aacccatggc 2272201 aagcgccgta cgcaattctt tctccgcttc ttcaccgccg accgtgacag cggtgatcgt 2272261 gccgccatgc ttttccttca gctggatggc ttcttctatc gcgtactcat catatggatt 2272321 aatgatccat tccgctccgt catcctgaat ctttcctgtt tcaatgacga ttttttcttc 2272381 tgtgtcaaac gtccgtttca tcagtacaaa tagattcatg atcatatccc cttttattcg 2272441 cctttgaact gaggctttct tttttcgaga aatgcctgga tgccttcctt ggcgtcctct 2272501 gactcaaatg cttccccaaa tcgctttgct tcaagcttta agctgccttc ataggaatac 2272561 accttgttgg aataaagaag ttcaagcaaa gatgccagcg tttgcgggct tttctctgca 2272621 aacttagcgg caagtgcttt tgctttttca atcacttctg cctcatcttt cgctccaatt 2272681 gagacaagtc cgagatcaag cgcttctttt ccggatatcg gttctcctga tccgatgagc 2272741 tccagtgctt tggctgtacc gacatatctc ggaaggcgct gtgtccccgc aaaacctgga 2272801 atgataccga gattaagctc cgggagcccc agcttagcat cttctgccgc gattctgatg 2272861 tgacaggcca ttgcaagctc cagcccgcct ccgagagcag cgccgtgaat cgctgcgata 2272921 atcggttttg gaaaactttc gattctctcc attaactgct ggccgcgctc agcgagcaat 2272981 gaggaatcct cattgccttt aagcgatgta aattctttaa tatcagcgcc ggctgagaaa 2273041 aatcttccct cgccgtgaat gataatgctt cgtacgcctg catctgtctc acattgatca 2273101 agacaggaag acagctcttc taatatccgg cttgaaagcg cgtttgccgg cggattgtga 2273161 atcgtcaaga ctgccacaaa ttgatcaacc gcaagtgaaa ttgcattcat aggacagaac 2273221 tcctttactt attgtgaatt ccggatacca ataattctaa aacgctgttt gaaagcgcaa 2273281 cgagatcgta cttttggtca ttcatcaccc aagttgtcac agtttcgtca atcgttccaa 2273341 aaatcatctg ccgggcgagg cggacatcga ggccttcttt tatttcgcct gattgtatac 2273401 cttccgtcaa aatgccatcc aaaatattta agtagccttt taatatttcg ttgatttttt 2273461 ggcgcagctc caagttggat tggcggagct caagctgcgt gacaatggcg agattatggt 2273521 cacccgctaa aagggaaaaa tgctttgaaa tcacaagcgc caatttctct ttcgctgttg 2273581 ctttttcttt aatgtcctct tccatccgct caataaattg acccattttt tctttgaaaa 2273641 gagaaattaa aatatcttct ttgtttttaa aatagagata gatggtgccg tccgctaccc 2273701 cggcttgttt ggcaattttg gatacctgtg actggtggta gccgttttct gcaatgactt 2273761 ctactgctgc atcaataatc tgcatatact ttggccgttt ttgcttcaat gttcatcgtt 2273821 ccttcctata gaaatgaatg actattcatt cataatttca tgataagaag gattttcagg 2273881 tttgtcaagt ttattcatag gcgttctctt tttttatttg atatgatgat tttcggtttc 2273941 ttcttcaagt aaacgccttc ttaaaatttt tcccaccgcc gttttcggca gctcctttct 2274001 gaactcatag gctttgggca ccttataggg agctagacgt gatctcgcaa aagcgtccag 2274061 ttcttctgta tcggcttttg cgcctttctt taatacgaca aatgctttta ctgtttctcc 2274121 cctgtaggaa tcgggaacgc ctgcgacaac aatttcctgg atggcttcat gttcataaag 2274181 cgcttcttct acctcacgcg ggtaaatatt gtaaccgccg gcaatgatga tatccttctt 2274241 cctgtcagca atatagaaaa agccttcttc atccatatag cccatgtccc cggtgaacag 2274301 ccagccatct ctcagcactg cggcggtttc ctctggttta ttccagtatc ctttcatgac 2274361 ttgcggacct tttacaatga tttctccatg ctcatacgga gcggcaagct cacccgtctc 2274421 ttcagaatag atcgcagcgt ccgtactcgg ccaaggacag ccgatactgc ccggcttgtt 2274481 ttttccccag ataaagttgg cgtgcgtcac tggggatgcc tcagacaaac catagccttc 2274541 cacaagcttt ccaccagtca ccttttcaaa tttctgcttt acctccacgg ggagcgcggc 2274601 tgatccgcta agacagcttt taatggatga cagatcataa tgctgcaatt cagggtgatg 2274661 caaaaggcca atgtaaattg tcggtgcgcc aggaaagagc gtcggtttgt gtttgtcgat 2274721 gattttaagt gtttcgagcg gatcaaactt aggaagaaga atcatttcga agcctagttt 2274781 aatcgaatag ttcatgactg ccgtcagtcc gtagacatga aaaaatggaa cgatgcccag 2274841 cactttttca gcgccttctt tcacgtcata catccaagcg gcgcacattt cagtatttgc 2274901 caaaatattt tggtgcgtga gcatgacccc ttttggagct ccggttgttc ctccggtata 2274961 ctggaggaca gcgatatcat gctcaggatc gatcttcggg attgtcagga gttcagtttt 2275021 ttcctgcttc atacaggaag cgaacgtgtg aatgttagct gttttgtcaa agtcgatatg 2275081 cactttttgt ttttgcgtca gcgggtaaag aatatttttc ggaaaaggca aatagtcttt 2275141 tacactggtt atcaaaatct ggtcgactat tgataacgtt ttcattttta ttgccttcgg 2275201 gaaaagcaaa tctaaggtga tgattacact tacctgagca tctctaagct ggtattcaag 2275261 ctcatgctcg gtataaagcg gattcgtctg caccacgatg ccaccggcaa acaagacgcc 2275321 ataataagaa atcactgttt gcgggcaatt gggcagcata acagccactc tgtctccttt 2275381 ttgcaggcca ttgcactgca aaaaagctgc aagtttaaga gcatccgtca gaatgtcatg 2275441 aaaggtgagt ttttttccat aaaacgatat tgcggtttta tcagggaatc gtgcggcgga 2275501 gtctgtcagg atggattgca gggttttatt cggcaacgga agctcatgcg ggatatcgtt 2275561 gggatactcg gcaagccacg gcttttgaga ctgcataaaa cctccccttt cgattttaga 2275621 gatccacctt atcattatag cagatggacg gcaaaaaaaa gaaaaagaaa ggtaaatctt 2275681 tctttttctc ataatatgaa cagatatata agaccaatta acaaaaagat tcccgctgcg 2275741 gcgagcagta ttttcgcaag cttttccatc tattctccgt ccccttatat tccggctgcc 2275801 accacaaaag aaagcccgac agaaatgaca aatgaaataa agccgacagc ccggttatca 2275861 ttttcgattt cctgatcaat tttaaaccgc ggagtcaaaa actcaaaaat aaagtagctg 2275921 atcagaagca taacaaaccc gtaaacgccc cagccgatca tttgcagcag cgaattatgc 2275981 tgggagatgg aatgctgaaa tacgtttgcg attcccaaaa tttttccgcc ggtcgccatt 2276041 gccaccgcaa gatttccttt ttgaatctct tcccagtttt tataagccgt caccagctca 2276101 aacacagtca aaaagaggac gaggcagaga accgcgacac tgtaatatgc cgcgatttcc 2276161 acaagctcgt tttcccaaaa atcactcatg gccatactcc cttttatttt agttcaacaa 2276221 ccgtaacgcc tgatcctccc tcacctgctt caccgaaacg ggaacttttg acgctgcggt 2276281 ggtttttcag aagatcctgt acgccttttc ttaaagcgcc ggttcctttt ccgtggatga 2276341 ttgacactct tggatatccg gctaacaccg catcatccaa gtatttttca acccggctga 2276401 gggcattttc atagcgttcg ccgcgaagat caagttcaag cgatacgtga tagtcctttc 2276461 ctttgaccgc tgtaatcatt ttttcttttt ttggctccgg agctgatttg ataaactcca 2276521 gatctttttc ttttactttc atctttaaaa taccgatttg aacgttccat tcattgccgc 2276581 ctgttttttc gagcaatgtt cctttttgcc cgaaagtgag gactttcacc tcgtcgccag 2276641 gcttaaagtc gcgtttttgc gttttcggct tttccggttt cttggacttt tcaaaagcag 2276701 gcatagcgcc ttctaaccgt ttcttcgcgt taatcagctc gtgatccttg aaggatttgt 2276761 gttcttcttt tatggtgcgc aattcatgaa taatgtcctc ggcttctttc attgccgctt 2276821 ttactttttc agcagcctgc tgttctgcct cttcaagcat tttgtctttt ttgctgttaa 2276881 gctcgatgat ttgctgctgc agctctttat gcagtttttc cgcttctttt ctgattgatt 2276941 ctgtctcaga aagctcttct tccgcacgtt ttttgctttg ttccagcgac gcaatcatcg 2277001 tatcgacttc gttatgctcg gccgtcattt ctgacttcgc ctgcccgatg atatggtccg 2277061 ggagcccgag gcgttttgaa atttcgaaag cattgcttcg acccggcaca ccaattaaaa 2277121 gtttataggt cggtgacagc gtttcgatgt caaattcaac gctggcattc atgacgcctt 2277181 ctctgttata gccgtacgcc ttcaattccg gataatgcgt cgtagctaac actcgtgcat 2277241 tggtgcgatg cacgtcatcc aagatgctca tggcgagggc cgccccctcc tgcggatctg 2277301 tccctgcacc aagttcatcg aaaagcacaa ggctgttttc attgacctgt tctaaaatgc 2277361 cgacaatatt caccatatgg gatgagaacg tacttaaact ttgctcaatc gactgttcat 2277421 caccgatatc agcgaatacg tgctcaaata ctgccgcttc tgacccttca tctgccggga 2277481 tatgaagacc tgactgcgcc attaaggtta gcaggcctaa cgttttaagg gtgactgttt 2277541 tccccccggt gtttggccct gtgatgacaa tggttgaaaa atcgcggcca agctcgatgt 2277601 cattggcaac aacctgatca ggcggaagca atggatggcg ggcttttttc aaacggataa 2277661 agccggtgtc gttcataatc ggttttgtcg ctttaaccgc ttttgcatat ctagcttttg 2277721 caaaaataaa gtcaagcgtc tgcagcactt gcaaatctag aaatagctcc tctgtatact 2277781 ctgccgtttt ctctgtcagc acacgcaaaa tccgttcaat ttcttgcttt tctttcactt 2277841 tcgcctgctg aagggaattg ttcatatcta caatcgcctg cggttcaatg aatagtgtcg 2277901 caccagagga tgaggtgtcg tgcacaattc ctccatagct ggatctgtac tcctgtttga 2277961 ccgggatcac aaagcggtca ttccgaatcg taacaatcgt atcagacagc attttcgatg 2278021 cggaagagga acgcagcatc gactctaacc ggtctctgac tcttgattcg agtgttctga 2278081 gctgtgtgcg gattcctctt aatgtttccg atgcatgatc aagcacttct ccgtgatcat 2278141 caatgcagga attaatgtcc cgctctaaat cggacagcgt gataagctgt tcagcatgct 2278201 gatggatcag cggaatgtcg acaccgtctt cagccatttg cgtgataaaa tgtttcattt 2278261 gtttaactgc ataaagcagg cctgagattt cagtgaattc agaaggactg agaacgctgc 2278321 cgatttccgc ccgtcttaac gctcctctga tatctacaag gccgccaaat ggcgcttggc 2278381 ctctcagccg gataatgtca gaagcttcgt ctacttcatc cagctgtttt ttgatttcgt 2278441 ctatagaagc agaaggctta agctcgagaa gcatttcttt tccgagcgat gaagcggcat 2278501 gcccaataac ctgttctttc actttatgaa attcaagagc tgataatact ttttgctgca 2278561 cgattgtgtg agcctcctta cttaatcgtt gcgcttcaga aatgcctcta cgtctttaag 2278621 cgaccgggca ttcagaacgt ttttcgtttc cgtccatcct ttgcgcgcgg cagtaacgcc 2278681 agttttcata tcgtctaaca tctcaatatt atgggcatca gtattaatca ccaatgtaac 2278741 cccttgttcg tttgctttca ttaaatgctc tgtgcgcaga tcaaggcgcg cagggttggc 2278801 attgagttca agcgccgtat ttgttttcct cgcaagctca atcagctgat caatatcgat 2278861 ttcgtaaccg gcccgtctgc cgataaggcg cccggtcggg tgtgcgataa tgtcaacatg 2278921 cttgtttgtc agtgccgtct caagccgttt cataatcacg tgttccggct gattaaaact 2278981 ggaatgaatc gatgcaataa cgatatccat ttccgcaagc acatcgtcat cataatcgag 2279041 cgtaccgtca ggcaggatat ccatctcaac gcctttcaaa atacggaagt tttcaaactc 2279101 tgcattcagc gcgtcaattt cttttgcctg ctgcttaagt ctttctgcag taagcccgtt 2279161 ggcgaccttt aaatattgtg agtgatcggt gatcgccatg tattgatagc cttttttgat 2279221 gcaggcttca gccatctctc tgatcgaaaa tgcgccatcg ctccacgttg agtgcatgtg 2279281 gagatcacct ttgatttgcc cgagctctat cagttcaatg ctgtcgctgt aggtttccac 2279341 ttcctgtccg ctttcacgaa tttccggcgg aatcagcggc aggccgaagt gcgcataaaa 2279401 ttcacgttca ctcggaaatg ttttgatctc tccggtttca actgtctcaa cgccgtattc 2279461 actgatccgc tcgccgcgtt ctttggcgat ttggcgcatc ttaatattgt gatcctttga 2279521 tcccgtaaaa tgatggagtg ttgtcggaaa ctgctcttcc gtcacaagac ggaaatcgac 2279581 gcttgtttca tattcaaagg aaaggatgac ggacaccttc gtatctccgc ttgcgatcac 2279641 gcttttgatg tttggcagct caagaagctg ctctcttact tcagccggat gatctgtagc 2279701 aatgatataa tccagatcct tcaccgtttc ccgcgctctg cggagacttc cggcacgaga 2279761 aaatttgatg atatgcgtaa attgagaaag atgctcctca atttcccgcg cgatccggag 2279821 ggcgtagccg atcgggaacc gttcaggctg ttttccggct tccccgagcg cctgtaatat 2279881 tttttcttcc gattttttgc cgaagcccgc aagaccctgg accttttgct gctcacaggc 2279941 ttccttcaga gattctgcat cgtgtacgcc gagctcttta tacagctttg cgattttttt 2280001 gccgccgagc cccggcagct tcaataaagg cacgagtcct tccggcactt ctttctgaag 2280061 cgattcgagc gtgcttgact ttccttcatc tatatactct ttaatgacgc tgtacgttcc 2280121 ttttccaatg ccggacagcg acatcatatc gtccatttct gataagcttc ggtcgtcctg 2280181 ttccagagct gccgccgctt ttcggaaggc ggatacttta aacgggttgt cccctttgag 2280241 ttccatatag actgcaatgg tttcaagcag ccggataata tcttttttat gcatatcata 2280301 acccccagac gttcacatat gtttccatca tacttgaaaa aaacttctcc ggacaagaga 2280361 agttttttta tgccccgtac tgtgtccaca gctcttgtaa aagccctgac aagtacggtg 2280421 tatggttaat gatcacattt gcgagagacg attgccccat catttgctgc aacgcgtcta 2280481 ccggcagaac ggatgcgaca tacagcagca caaatgtaaa taaatagact tctagaaaac 2280541 cgagaacggc tcccagcatc tggttgattt gtttaatcac cggaatgccg gctacaatac 2280601 tcaggaacga gccgatgatt ctcagtaaga ttttagcaat gataaataaa acgataaacg 2280661 caatcgcatt atagtacgct gcttccaaat tccccgtaaa aaaagaaaga gccggctgtc 2280721 ccgctgaaaa atcgggtgcg ggaatccaat gtaaatgcgg tgccacgttt ttatagaata 2280781 aagccgcaaa ggcaattgat aaaataaagc tcgtcaagcg gataaactgc aggataaaac 2280841 cgcgttttaa ccccagtaaa gtccccatca ggagcaagat taagatgatg atatctagca 2280901 tagttgttca atccttttct ttaagctgac gctccagttt ttcacatttc tcttgtaatt 2280961 tgacataatc gtgcaccaca tttaccgctg tcagcactgc aagtttattt atatcaaggt 2281021 atggattttt ttcattgatt tctctcattt tatcatcaac aattccggcg acatacctca 2281081 tatgggctct gctttcttca ccgacaatcg tgaagtgctg gccgtaaatg tcaacggttg 2281141 tttttgtttt tttgccgtca gacaacgttt ctcctccatt ccgcgagaat cctagttctt 2281201 atcataacac gtttattaaa tgaatggaaa gacgagcctc ccgctgttat gatacactgg 2281261 tatatacagc gaaaagtgta aaaaaaggag attattacgt gtcccattca gtgataaaag 2281321 tatcgttgtc tgctattgac caaatgaaaa tgacgtacag cggttcactt acagcctctg 2281381 ttccgcaggg agccgttttt caggcaaaac cgcccggctg taccattaca gcatatcaat 2281441 caggtaaggt cttgtttcaa ggaaaaaacg ctgcggcaga atccgcgcgc tggggaacag 2281501 cagagcctca ggaaaagaag aaaacggcca aaaagccggc tgatccccgc tatgcccctc 2281561 cggcagatat cgccggaatg tctgttatcg gttctgacga agtcggaacc ggagattact 2281621 ttggcccaat gacggttgta tgcgcgtacg tcgacaaaac catgcttcct ttaatgaagg 2281681 aactcggtgt taaggattct aaagatttaa aagatccgca aatcatcgag attgcccgaa 2281741 acctgattaa aaccattccg tacagcctgc tggtgttaaa gaatgaaaag tataacagca 2281801 tgcaggaaaa aggcatgagc caagggaaaa tgaaagcttt gctgcacaat caggcgatca 2281861 cacatttatt aagaaaattg gatggagtaa agcctgaagc cattttgatt gaccaattcg 2281921 ctgagccagg cgtctacttc aatcatttaa agggcagaga cattgtgaag gagcggacct 2281981 attttagcac aaaagctgaa ggtattcacc tggctgtcgc cgctgcttca atcattgcaa 2282041 gatattcatt tttaatggaa atggataaac tatcacgcgc ggcaggaatg acgcttccaa 2282101 aaggggccgg tccgcacgtc gatgaagcgg ccgccaagct gatcctcaaa aaaggggcat 2282161 ctgcactcag aacctttaca aaactccatt tcgccaatac gcaaaaagcg cagcgccttg 2282221 ctgataaaaa acgttcatag aaaaaagctt gcagatttct ctgcaagctt ttttatcagc 2282281 ctcttaaaac agcttgatat gtgtcttcta acgctttcag cactttgctg tgcgcctttg 2282341 tcacttcttc ttcagtcagt gtttgttcag gattgacata ctggagtgag aaagcgactg 2282401 acttcttgcc ttcctccata tgctctcctt cgtatacgtc aaatacggtt acctctttca 2282461 gaagcttgcc cccggcctct ttaatgacgc tctcgagctg tccgcttgtg acggttttat 2282521 ctgttacaag agcgatatca cgtgtcacag acggatattt tggaatcgcc gtgtaaacaa 2282581 gcggtgctgt ttctgctgcg agcaacgcat gaagatcgag ctcaaatacg tatgtttcct 2282641 ttatatccag ttctttttcc aatgaaggat ggacttggcc gatgaagccg atcagagaac 2282701 cattcaataa aatgttcgct gttctgcccg gatgcagctg tttgcgttca gactgtacaa 2282761 attcaatgct gtctaggacg ttgagtttgt ctaacagccc ttccacaatt cctttgacaa 2282821 caaagaaatc aactggtttc ttttcaccct gccatagctg cttgcgccat aatccggtaa 2282881 cagctcctgc tacgcgttct gtttcaacag gttttgtgtc ctcttccttc gttaggaaaa 2282941 cggagccaac ttcgtacagt gcaactgagt cagtctgcct cgcaagattg taagaaacag 2283001 aatcaagcag atttggaaca agactgtgtc tgagaatgct tctttcttca ctcattggaa 2283061 gcgcaagcac agtattcagt gatttttcaa tcgcaaacgc tgtcgctttc ttctcgtttg 2283121 tcagtgagta agtgatggct tgtgataagc ctgcgccttc aaggaagcgt ctgactttac 2283181 ggcgttttgc ctgatatggc gttaatccgc ctgtagttcc cgctgtctca ggaagcgtag 2283241 acggaatgtt atcgtagccg tacagtcttg ccgcttcttc gattaaatcc tcttctattg 2283301 taatgtcacc gcgccgtgat gggacagtca caacgagaag atcatccgct tcaccgaccg 2283361 taaaaccgag acgtttataa atgctgatca gttcttcttt actgatcgtc aggcctagaa 2283421 cgctgctcac tttgtcagca gatacgtgaa tgttatttgc ttcgattgtc aggtgatctt 2283481 cctcaaccgt tccagcaagc acctcaccgc cggcatacag atggatcagc tgcgcagccc 2283541 gttctgctgc aagacgtacg cgtgccggat caattccttt ttcaaatctt acgcttgatt 2283601 cacttctcaa accaaggtct ttggaagcct tgcgaacctt ctgcccgttg aaatacgcag 2283661 cctcaagcaa aatggttttc gtatcttcct gaacctctga ctctgctcct cccatgacac 2283721 cggcaacggc ctgcgctttc gttccgtttg taatgacaag gtgatcggca gacagcttac 2283781 gttcttgatc atcaagtgtt acgatcattt cattctcagc tgcttttctt actacgactt 2283841 ccttagagcc aaatctgtca taatcaaacg catgaagcgg ctgtccgtat tccaacagga 2283901 caaaatttgt gatgtcaacg acgttgttgt gcggacgaat gcctgcattc atcagctttg 2283961 tctgcatcca aagcggtgac ggagcaatcg tgacattttt aatgattttt gcagtgtaca 2284021 gcgggttcgc ttcttgatct tcaattttga ctgaaatgta atcagacgct tgttctgaag 2284081 cagccgggta atccgtttgc ggaagcttta cctcagtgtc taaaatcgcc gcaacctcgt 2284141 aagcaacacc aagcatgttc atggcatccg cgcggtttgg cgttaaaccc agctcaagaa 2284201 tcgcatcgtc aagctgtaaa gccgctaagg catcgcttcc tgtttcagcg tcattcggga 2284261 atacgaaaat gccttctgca tactccttcg ccacaagttt gctttcgata ccaagctcct 2284321 gtaaggaaca gatcatgccg tttgattctt caccgcgaag cttggctttt ttgattttga 2284381 aattgcccgg cagcaccgct ccgactgttg caactgcgac tttttgtccc ttatccacat 2284441 tcggcgcgcc gcaaatgatt tgtacagggg cttcagctcc gatatccaca aggcacttat 2284501 tcagcttatc agcattcggg tgctgctcgc gctccagcac atggccgatg acaacgcctt 2284561 tgatgccttc tcctttgtat tcaattcctt caacctcaat accggctctt gtaatttttt 2284621 cagcaagaac agccgggtcc atgcctttta aatcaacata atcctctaac catttataag 2284681 aaacaaacat ccttgcatcc tcctcttacg cctgtttaaa ctgcgaaata aatctgacat 2284741 cgtttgtata gaagtggcgg atatcatcaa tgccatattt cagcatcgcg atgcgctcaa 2284801 cacccattcc gaatgcgaag ccctgatatt ccttcggatc aaagccagcc attttaagca 2284861 cgttcgggtg aaccattccg gcaccgagga tttcaatcca gcctgttcct ttacatactg 2284921 agcagccgtt cccaccgcat ttaaagcatg tcacatccac ttctactgaa ggctcagtaa 2284981 acgggaagaa gcttgggcgg agtctgattt cacggtcttg cccgaacatt tttttcgcaa 2285041 caagttcaag cgttcctttt aaatcactca tgctgatgtt tttgtcaacg acaagccctt 2285101 caatttgcat aaattggtga gagtgcgtcg catcatcgtt atcacggcga tatactttac 2285161 ccgggcaaat gattttaacg ggacctttgc cttcatgctt ttccatcgta cgtgtttgga 2285221 caggagaagt ttgcgttctc atcaaagttt cctctgtgat gtaaaagctg tcctgcatat 2285281 cgcgcgctgg gtgttctttc ggaagattga gcgattcgaa gttgtagtaa tccgtttcaa 2285341 cctctggccc ttcctcgact gtgtagccca taccgataaa taaatcttca atttcttcaa 2285401 tgacaacagt gagcggatgg cggccgccga ctgcaacagg gttccccggc agcgtgacgt 2285461 caattgtctg tcctgcaagc ttctgtttca tttcctcttc ttcaagcttc tcgtttttgt 2285521 cagcaatcgc attggcaata cgctccctta cttcgttcgc gagcgccccc atttttggac 2285581 gttcctcagc agaaagcttg cccattccgc gcagcacttc tgtaatcggc cctttttttc 2285641 cgagatattg cacccgaata tcattgacaa ccttcaatga gcttgccgct tctacttgtt 2285701 ctaaagcttc ttgttccagc tgttttagct tttcttccat tttgcatcct ccttttatgt 2285761 aaacaaaccg tcatatgtct ttggaaaata aaaaaaaccc gtcccttgta caagggacga 2285821 gttgtggccg cggtaccacc cttatttcag acagactgat gctgtcgtca gcttcattga 2285881 cataacggaa tcagattccg gttcaccttt acgcgcagtg tacgcggtcc cggcgacaac 2285941 tcaagaggtg aagccaattt ccggctgcgt taaaaatgct ctcagtcagc ggcattttct 2286001 ccctggaaag cagttgatca gaaattgagg tcctctgtca cggtttttga aatattatgt 2286061 tctattatag agaaatccaa cgcttggcgc aacactatcc tcgcaagtga tacacgagga 2286121 tggcagccgc aaccgcaacg tttagtgatt cagcctgtcc gtaaagcggc acgtacaggt 2286181 tcaaatccgt tttttccagc aatgcagcat ctacccctgc accttcattt cctacaatga 2286241 gcgcaaagga ttcagactga ggaatctcct ggtaaggcgc tccgttttgc agcgccgtgc 2286301 cgtatacttt tacgccctct gccttcaatt cgtccacata tgaaggcagg tttcttctca 2286361 caacaggaat atggaagtga gatccttgag cagatcgcag tgtttttccg ttaaaggcgt 2286421 ccgccgtgcc gtcaccgagt acaaccgcat ccaaaccggc cgcatcagcc gttcgaatca 2286481 ttgtgccaag gtttcccgga tcttgaacag cgtcaatcag cagcaccttg cgtgccgttg 2286541 ccagcttttc ttcaggcata tggcacacag cggcaatctg ctgcggcgtt tcggtttcag 2286601 tcacagctga aaacgcatct tcactcagca tatagcactg gataccagtc tcaagatctg 2286661 aaggaatcct cgtttcatcc tttacaagga tttctttcac aatgcccggg cttttcaacg 2286721 cctcttcaac gaggtgttct ccctctatca gaaatgtatt tgtttttgtt cgttcttttt 2286781 ttgtgtgaag ctttttccaa tccttcactt tttggttttt tgccgattct atttgtttca 2286841 ctgtctatgt ggcgctcctt tttttaacat gatgttatta tatcgcaaga acagcacata 2286901 ataaaccagg tgcagggtta gaatatacgt attacatttt agaaaaagga gcgttttaca 2286961 tggatcttaa tttacgtcat gccgtcattg ccaatgtcac cggcaataat caggagcagc 2287021 ttgagcatac aatcgtagat gcgattcaaa gcggtgaaga aaaaatgctt ccagggctcg 2287081 gcgttttatt cgaagtcatt tggcagcacg catccgaaag tgagaaaaac gaaatgctga 2287141 aaacgcttga aggcggatta aaacccgccg aataagacat gaaaccgggt gacagcgccc 2287201 ggtttttttc ttatataata aaaacatgat gagggggaac gccatgtttt tacagccgtt 2287261 attagcgaaa aaaattattg ctgaagttaa aaaaatgtac gaacgtgaag tcattattgt 2287321 aaacacggac ggtcttatta tggcaggcac aaacgatgag cgtgtcggac aatttcatga 2287381 gggagcgctt atctgcgcaa aagaaagacg cagcgtgatt attacaaaag aagatgaaac 2287441 aaggttaaaa ggagtgaaag caggcataaa cctccctgta ttttttgacc atgatgtgat 2287501 tgccgtcttc gggctgacag gtgagcctgc agagattcag ccattcggag aactgcttcg 2287561 aaaaatgaca gaactgttca ttaaggaatc gcggcactta gagcaatccc agtggcgtga 2287621 gagaatgctg gagtccttta tgatcgattg gctgcaatta aaggagtggt ctcccagttt 2287681 tcttgagaaa gctcagcttc ttggtgttga cctttcttcc cggcgccaaa tgattcttat 2287741 tcaggggtat gagtggtcac ctcatgatat tgaacaaatg gcacgcagct ggaaatcctc 2287801 gtaccctgcg gatttgttca tcaggtgggg aaatgaacgg attttgatta atcatgaagt 2287861 gccgcagcat gaacaaaggg atcggctttt gcggaaaatc cttcacattt gttcgtttgc 2287921 caataccgca agcagccaat atacagcagc tggcgccgga agggctgtcg caagctccag 2287981 cctgacagat tcatacgagc aagcggaaaa agcgctggct gtcagcctta agcgaaaaac 2288041 gcccatattt gaagaggatc tgaagcttga tatgtgtctg acggagatca gcccgggaac 2288101 ccgaaacgaa tttccgcaaa gagtattagg aaaggcgcta gagcatcagg aacttatgaa 2288161 tacgatacgg actttctttc atcacgattt gtctttgaaa caaaccgctg aagacatgca 2288221 tatacacatc aatacattgc gttatcgtct ggctaaggct gaacagctga cgggattacg 2288281 ttttgaccgt accgaggacg tcgtcacgat gtacgtcgca ctctattttt tagatcaaga 2288341 tacaaaatag agagagtttc agtttcattt tttgtatgtt tctccatgga aggctttgct 2288401 ttttttcttt tacaatagat tgaaagcgtt ttttgacagg gggatgggtg aaatgatcac 2288461 caaggatgta aaggagcagc tgattcaggt ctccggacca gaaaactttg atgactcgaa 2288521 tgccggccgt ctcgtctatt catatgatgc gacgcctcag tatcagtcta tgcctgatgc 2288581 cgtgattgct ccgaggaata ctgatgaaat atcacgcatt ttaacaattt gcagcgaaca 2288641 tcgagtgccg atcgttccaa gaggatcagg gacaaacctg tgcggcggca cgtgcccgac 2288701 tgaaggcgga cttgtgcttc tctttaagca catgaaccag attcttgaaa ttgatgaaga 2288761 aaatttaact gccacagttc agccgggcgt cattacgttg gatatgatcc gggcagttga 2288821 aagcaaaggt ttattttatc cgcctgaccc gagttctatg aaaatatcaa ctatcggggg 2288881 caacatcaat gaaaattccg gcgggctacg cggattaaaa tacggtgtca cccgcgacta 2288941 tgttattgga ctggaggttg ttctcgcaaa tggtgacatc atccgcaccg gcggaaaact 2289001 cgcaaaggat gtggccggat acgatctcac acgtcttttt gtcggctcag aaggaacact 2289061 cggcattgtg acagaggcaa tcgtcaaact cgttccaaag ccggaaacaa agaagacgct 2289121 gcttgccctt tatgaaaaca tcgatgccgc tgctcaaacg gtatcggaca ttattgccgc 2289181 aaaaattata cccgctacgc ttgaatttct cgatcagcct acactattgg tgattgagga 2289241 ttatgccaaa atcggacttc cgacaagcgc aaaagcagtt ctgttaattg aacaagacgg 2289301 gccatttgaa actgttgaac gggatatgga aaagattgag gcgatctgca aaaaaggcga 2289361 cgccgtatcc gttcagaccg cacaaacaga ggaggaagcg tttgccctga ctgaagcccg 2289421 gcgttctgca ctttctgccc tagcccgcct caaaccgacg acgattttag aggatgcgac 2289481 cgttcctcgc tcagaaatcg ccaatatggt taaagcgatt aatgatattg ctgctaaata 2289541 tgatatttcc atctgcacct ttggtcatgc gggagacggg aaccttcacc cgacatgcac 2289601 gacagacata agaaataagg atgaaatgga acgtgtcgaa caggcttttg ccgagatttt 2289661 tgagaaagcg attgaacttg gcgggacgat aaccggagag cacggagtcg gggaaatgaa 2289721 agcgccttac ttggaaatga agctgaaaaa agaaggcatt gatgcgatga aagcgttgaa 2289781 agcggcattt gacccccgga acatattaaa tcccggcaaa atgtttgcga aagatgccag 2289841 aaaacgtgtg gtggcggaaa gatgacaaca gaaaaagaaa tgaaacagat ccaaaatgaa 2289901 tttaaagagc gtatggatga aggagagtta ttaaattgta tgcgctgcgg cttctgtctt 2289961 ccttcctgtc cgacctatat cgaatcggga tttcaggaaa cacactctcc gcgtgggcgc 2290021 atcgccttaa tgaaagccgt agccgacggt atgattgaac cggatgaaga tgtcgaacgg 2290081 tcgctgtcac tttgcctcgg ctgccgcgcc tgtgagcctg tatgcccgtc tggcgtgaaa 2290141 tacgggcagc tgcttgagga agccagagat attatccacc aaaataaaaa acactctctt 2290201 ggtgaacgtg tcatgcgaaa gacggctttt cacgagctgt ttccgcatca aaaccgcatg 2290261 cgctcagctg taagccttat cggtttgtat cagcgttcag gactgcaaac cgctgtgcga 2290321 aaatcaggca tgcttcgggt cctgcctgag catttgcgga cgatggaagc tgttcttcct 2290381 gatgttccaa aaagcaaaga catgaaacat cggccgcgtt tcctgccttc cattggcccc 2290441 atgaaaaaac gggtcgcctt tttttcgggc tgcttaatgg atacaatgtt tttaccgacc 2290501 aataacgcca cattgaagct tttacagctg gcaggctgcg acattgtcat tccgcctgaa 2290561 caggcttgct gcggggcgct tcatggacac agcggtgaaa aaaacacagg gaaagagctc 2290621 gcgaaacaaa atatcgctgc tttcgaagca ttagacgtgg atgcagtcat tacaaacgca 2290681 ggaggatgcg gagcctttct cactgaatat gatcatttgc tgaaggatga ccctgagtgg 2290741 tcggaacggg ctgccgcttt tgttcaaaag ctgaaggatt tttcttctgt tttggttgaa 2290801 ctcgatttcc atcaaatgga tctagcactc gagacgcctc aggtcgttac ctaccaagat 2290861 tcatgtcatc taagaaatgt gatgcatacg tcacttgagc cccgccagct tcttaaaagc 2290921 atcaaagggg cggaattcaa agaaatggag aaagcagaca gctgctgcgg gtcagcggga 2290981 atttacaaca tcgtcgaagt tgaaatgtct atgaaaatac tggacagcaa aatggctgcc 2291041 gtcaaagcaa ccgaagcgat cctcattgta acagcaaatc ctggctgcct gctgcagatg 2291101 aagctcggca ttgaacgcga aggactaagc ggtaaagtca gagccgttca cctggctgat 2291161 ttgctattag aagcagccgg gcacaaaaca tcatgagaaa gcccaaaaca gacattgttt 2291221 tgggcttttg tgcgttattc catcggactg caaatttcga tataatgtcc atccggatca 2291281 gcgatatagg cgaccgtctg cccccatggt ttcactttcg gctccccgat aatcgatacg 2291341 ccttgttctc tcatcctttt gatgaccgct tctacatttt cagtaacaaa cccgatttca 2291401 aatgtgtttg aagcagatgt atccggaatg tccagcgccg tgatgtctct ggcgctttcc 2291461 cgggtattaa gcgccaatat cgtagaccct gtatcaaatt cgacatacgt gccgtgttca 2291521 gcacgaatcg gcagtcctaa aatatcccgg taaaaaatga atagcccgct tgctgtccga 2291581 tacgtataga ataagatatt tcattgatag attcattgcc aacccctctc agcattttca 2291641 atagtccttc tagcccggta tagatgcttc catccttaag ctcggatctt tccacatctg 2291701 cgcccatttt ttcacagccg ccacgataat gatgaagcct aacaccagca tgatgataga 2291761 taatacgcca ttcaatacac tatatcctgc tgcttcagga ttgagataca cattgcgcac 2291821 catccaatag cccgcataat tgacagtgac atataaatag gcaagcggga taaggcaagt 2291881 cagaatgtac cggcgtttat cggcgatttt cagcacgatc gtcgctccga taatcagccc 2291941 cactgaagcc atcagctgat tagaaacgcc gaagagcgcc caaatggaac cgatatctcc 2292001 tgaatacagc aagtaccccc acatcaaaca ggcaagcgcg ctggcaaata cagagcccgg 2292061 aatccagtct gttttcttca gcggcttata cacctccccg aagaagtcct ggatcaaata 2292121 acgggcgaca cgtgtgccgg cgtcaatcgc tgttaaaata aagaccgctt caaacataat 2292181 gacaaattgg aaaaagtatg aggccaaatg gctgaaaaac ggcattccgg taaaaatata 2292241 agtcatccct accgcaagcg tgacggctcc ccctgttctt ccttctaagt ccaaaccgat 2292301 ttccccgctc aattcaggca aatgtacgac attcatgcca agcgtacgga aaacctcagg 2292361 cgtgctgtta atcgcaaagt aatcagcagg ctgtaaagcg gtcgctgcaa tcagcgccat 2292421 gataccgaca agacactcaa caagcattgc gccaaacgca accggcttca tatcactcca 2292481 tttattcagc attttcggtg tcgttcctga gccgacaaag gcatggaacc cagagatcgc 2292541 cccgcaggcg atggttattg agatgaacgg ccagacaggt cctgccagca ccggccctcc 2292601 gccttttacg aattctgtaa acgcagggaa cggaatggac ggattgacga caaacacacc 2292661 aacaatcaaa gcgataaaaa caccgatttt cataaagctg cttaaataat cacgcggagc 2292721 cagaagcagc caaacgggaa gcgcagccgc aaaaaacgca taaacaggaa gcgcgattgc 2292781 aagcgttttc gtatctagcg ttaaaaagtc accgagcgcg gtagtctgta cccatggacc 2292841 gataaagact cctgccatta aaaagagaaa gccgaccgtt gaagcgagct ttaaatttcc 2292901 cgttttctta taaaataagc ccacacccat cgcaatcgga atcgtaatcc ccaccgcaaa 2292961 tgttccccat ggattacgtt caagcgcatg caagacaacc atcgacaggc ccgccattgt 2293021 gatcgtgatg ataaacagca tggacagtcc tgtacaaaat cctgcaacag ggccaagctc 2293081 atccttcgcc acttccgaca gcgattttcc gtttttgcgc atcgatgcaa acaacaccac 2293141 aatatcatgg acggctcccc caattaccgc cccgattaac agccacaata atcccggcaa 2293201 atagccaaac tgcgccgcca gaattggtcc gaccagcggc ccggccgctg cgatcgcggc 2293261 aaagtggtgg ccgaacgaaa cccatttatt tgtaggcaca tagtctttcc catcctcaag 2293321 cgcatgagca ggtgttggct tgtcatcatt cactttgaga accttcacca tcataaatgt 2293381 tccgtataaa cgataggcaa tagccaaaat acacattgat gctatcacaa ttgtaaccgc 2293441 attcattttc tcccatcccc ttttctgttt ttcataaata tatcataatt tcatggtgaa 2293501 aagcggtcat tttttcctat acaaaaagcc ggctggaatg ggccggctcg tggcagttga 2293561 aagacaagcc ggagagaaat ctccggcttt gctattctta tgactgtttt ttcaggcgga 2293621 tcacattcca ggaaagcggc gtgaaatgag cagttaagcc gttttcgctg acagacgatg 2293681 atccgttgga atgcggaacg acattttttc tgttatgctg gtttgttgct ttgatatcct 2293741 gatgctcaag tacgatgtgc tctgcgattt ggtaggattc aaagcctctg agcgaaatct 2293801 ccgtctccat ctgatcctca gccttgttta ccgcaaaaat agtgagtgtt tcttcctctt 2293861 cagagtacac aacagcagca tcaacatatg gcacatcagt gaaatcagaa caatcgtact 2293921 taggagaaga aataagcggt ttcagtgact cgccccttcc gtaaacagaa gcatgcatgt 2293981 atggatagaa aatcggctgt ctccatgctt ctccgccttt ttccgtcatg atcggcgcga 2294041 tgacattaac aagctgtgca agacacgcaa ttttcacacg gtctgcgtgc tgcagcatcg 2294101 taatgagcag agagccgact aataaggcat cttcaaaatt gtaaatatcc tctaaaatcg 2294161 gacgcgcagt gatccacggc tcgacttttt tatcagcctc atttgagtgg taccagacgt 2294221 tccattcatc cagagagaga ttgatagttt tcttgctgcg tgtttttgct tttacatagt 2294281 cacaggtcgc agcgactgat ttgataaaat gatccaaatc catagaacgt gccaagtagt 2294341 ttggcagatt gttatcccgg tttccgtagt aagtgtgaag agagatatag tcgacatgct 2294401 catacgtatg ctcaagcacc ttcgcttccc aatcgataaa ggtcggcata ccgctgtttg 2294461 agctgccgca ggcaacgagt tcaattgatg ggtcaaccca cttcatgacc tttgctgtct 2294521 ctgcggcaag ccgtccgtat tcatcagctg ttttgtggcc gatctgccat ggtccatcca 2294581 tttcgtttcc taagcaccat gttttgatgc catacggctg ttcatagcca tgcgatcttc 2294641 ttaaatcact ccagtaagag cctttcggat ggttgcaata ttcaacgaga ttacgggcgg 2294701 catctatgcc tcttgtgcca aggttgacgg ccatattgac ctcagtgttc accttttttg 2294761 cccaagataa aaattcattt gttcccactt cattggtttc tgtcgtttgc catgccaagt 2294821 caagccgtct cgggcggttt tcgactggtc cgacaccgtc ctcccagttg tatccggata 2294881 aaaagtttcc gcccggatag cggatgatgg gaacctgtaa ttctttgatc agcgactgga 2294941 catcttttct aaatccatct tcatccgctt cagggtgatc aggctcgtat atgccttcat 2295001 ataccgcacg acccatatgt tcgataaacg agccataaat ccgtttatct acttcaccga 2295061 ttttatattc tttgtctaca atcattcgcg cttttttcat cacacgtttc ctccttcatt 2295121 aacctttgac tccccctacc gtcaggccgg agataaagta cttttggaaa aacaagaaaa 2295181 tgataatcac cggcaaaatc gcaaatactg agccggatat aagcatgtcg taattatttc 2295241 cataagggct cagcaagctg gacagcccta ttggaagcgt aaacatttct ttcgaccgaa 2295301 gcacaatcag cggccacaag aagttgttcc agctgtttaa ggactgaagg ataatcatcg 2295361 caccgaaagc cggtttcatc agcggtgcca taatcctgaa aaagatgccg aattccgtac 2295421 agccgtccat ccttgcagag tccagcagat ctcttggaag gccaagagca tattgcctga 2295481 aaaagaaaac agcaacaggt gaaacgataa acggcaatat gacacccgta tatgaatcga 2295541 tcaagtgcag tccgacagta agtttaaaca gaggaagcat catcacttcc agcggaacca 2295601 tcataataat cagcacaaga acaaagatga tatttctgcc cttaaaatca taaaccgcaa 2295661 gcccgtaccc gatcatcgaa gaaaaaaaca gagtgagcac agtcgtaaaa agtccgagta 2295721 caagactgtt aaaaaaccat ttgaaataaa tgctgccgcc attaaacaga aatgtgtagt 2295781 tatcaaaact catcactttt ggatcaatat caagattcag ccccacacgc aaaagctcag 2295841 atgacggctt taatgatcct aaaagcaaac agaaaatcgg aaaaagatac aataggctca 2295901 gcatcataaa aaacagggtc agcgcaattc tataaacgct aaactgagga ctgtgccgca 2295961 acatttatcc ctccccctta aacgagcctg acagctttaa tgaaatcagg ctgacaacaa 2296021 ggatcacaat caaaagcaca atgccgatgg ccgctccgta tcccatttca ttgtaggcaa 2296081 gtccctgctg atacaaatat ccgacaagcg tcagaccaat attacccggg gaattattct 2296141 gccaaaggac gtagctttcc tcaaacatcc tgaagccgcc gatgatgctg atggtcagca 2296201 catatacggt tacaggcttg agaaacggca gcgtgatgtg cagaaatttt ttcattgtat 2296261 tcgcgccgtc tatatcagcg gcttcgtaca gctctttcgg cacattttgc aaacctgcta 2296321 aaaagtaaag gatgttgatt cccatccatc tccatgaagc aagcagcacc atcaaaaaca 2296381 tgccggtatg ttcattgttc atccagttct gaggtgaaaa gccgagttta agtaggatgg 2296441 aattggccag agacgtttcc atttctccga agatcagccg aaaaatgatc cccgcgacaa 2296501 tggttgaggt caatgccggg ataaataatg ctgatttaaa tatatttcta aatttgacca 2296561 gctttgaatt caggaatatg gccagaagca atggaacagg aatcagcacg atcagcgtcc 2296621 aaaaggtgta ttccagcgta ttccaaaggg cggtatagaa cgtcgggttg tttagcgctg 2296681 tataattaga caatccgaca aaggacacct ctcccggcaa aattctttgg aagctcatga 2296741 tgaagacact aatgatgggg tatagaaaaa atacgagaaa ggataaaacg aatggcgctg 2296801 taaacagata gggcgccgct ttttttgaat aaaacagatc tcgccagcct gattgtttcg 2296861 cagctgaagg aacgggatga accgttcccg ttttcacagg tttcatgaga acctccccgc 2296921 tttcactttt tgaatgggat tctatttctg tttcagttca cctgccgctc tgtccaaggc 2296981 ttgtttaggc gttttttgct gagatttaag cgcgtcgaac aatacgcttc tgttgacaag 2297041 gtctgaagcc ttggcaaaat cctcatgtaa ataaattgga ttgatttcat ccttgatatc 2297101 gagcagcaca gaaaaaatgc ctgttccgtt ttggaagtaa tccgtgtatt tgtttttctc 2297161 tttcaattcc ttggagctcc aaacatccca gcgaagcggg tcaaagccga gtacgctcca 2297221 gagtttttta tttccttctt cagagccctt cgcaaaggcc aaaaactctt ttgctaactc 2297281 aacatgcttg gattgcttcg gtacaacagt tgccgtaccg cccaaacctg ccgagcggtc 2297341 gcccccctct ttccatgccg ggagcggtct gatggcaatc ttccctttca gatcaggcat 2297401 ataatcgata aatcttccca tataccaaat cggcatgaga actgaagcag ctcctccttg 2297461 gttcataaag ccgtagtatt cttcactgtg atgcccgccg cccggcgcag gaatcatcgt 2297521 tttatcattg atcatgtctt ttaaatattg aagtgttttt acgttggtgt cattattgag 2297581 gatcagcttg ccgtttttat caaaatagcc tgagttttgc tgtgaaatca tagataagaa 2297641 cgttgcggaa tcatttgttt ccaccgttcc catcggcttc ccggtcactt tgcgcacttt 2297701 ctgtccggct ttatggtaat catcccatgt tttaatatcg tcaggattga cgccggcttt 2297761 tttcatcaca tccatgttat aaaacatgac cgttgtccct acatgtgtat cgagtccgta 2297821 aagctttccg tttttgctgt acaatgtcag ccgcgcctca acgaatttat cgcgatcctt 2297881 ttcaatcagc ggagtcaagt cggcaagcgg tatgtcagag cccttcaaaa agtttgaaaa 2297941 acgggccaat tcgacatctg caatatcagg aacgccttct cccgctatta gggagataga 2298001 taagttatcg tgcatttgtc catatggata aacgaccgta ttcagcttaa ttttgcggtc 2298061 aggatatttt ttgttccatt ccttcaccat ttccacatag aactgctcat gaagcccgtt 2298121 aaatgtccaa aaggtcagct cagtttcacc cgatttgccg gatgattttt ctgctgaaca 2298181 cccggcaatg actaatgtca gcaacatcat gagcacaaga aaacagacag tcattttttt 2298241 catctgcgtt accccttcca ttcgaggtgc gggctattca tatagaccat ggttgatcag 2298301 cgttttgttt tcattgatga ttcttaatcc ggtgcatcgg tctcttaagg tgtgcgcgtg 2298361 tctgaaggca tttttgacgg aatcctgccc gacaccgatt tcgtcaaaat acgcagggcc 2298421 tccggctgat ctcagccaat cagccagcac ttctcctctc gggagtgttt gataagccga 2298481 ttggatggct tcccggcggc ttggtgaaaa ttcgttcagc ccgtcatcct gagcgagctt 2298541 tctgtatgtg tcagttaata aaacagcggc acagcccacc tttgccccat gaagaatctg 2298601 aggccgtttt ttctccatta actccatttc aatccaatgt gaaatatgat gctcgccgcc 2298661 tgatgccggt cgggaatgat ctaatgccag catgacaagc cccgatacaa gtaaagactc 2298721 catcaaaacc cgtatgccag tttccgtttt catcgcaatg tcttctgtgt gttcaatgca 2298781 ggcagcaagc gcctcctgaa cgatcttagc tcctgcaggc gaataaggct caccggcaag 2298841 atgccgggat atttcccaat ctgctaaaga cgtgatttta ccgagcatgt caccaaagcc 2298901 agccgccacc attgactgcg gtgccgcttt taatagatcc agatcagcga acagcgcaga 2298961 tggggccttc gtttgaatgg ttgttttcgt gccgtataaa ataatcggcg caccggctga 2299021 tgtaaaaccg tctacagatg gagcagtcgg ataagaaata aacggcaaat ctctttgaaa 2299081 cgccgcaaag cggacgatat catgaatcgt gcccgaaccg actgcgatca tgacatccgt 2299141 tggttgtttc gtatggatca gcacatgaat gagcgatcgt tcatcagctg tcacatctcc 2299201 ggcttcattt tctggaatga tcaggcactc ggcctgaaat ccttcttgat tcagtcggtt 2299261 ttctaaatca attcctgcaa tgcggtgtgt attcgcgtcg cagacaagga caatatgttg 2299321 attgtttttt cgttttacat aatccaaaag cgaatcagct gcttgcttac cgagaacaat 2299381 ttcttcaact tttataggca acgtcttttc tccggcgttt tcaaaagcac gctgaacgtc 2299441 agctgcgata cgattcatat cagaatcccc tcctcagcca atttggttac atccttaata 2299501 gaatccagca cataatccgg cgtgtacaaa cgctgttcac cctgtttcgc agaaccagtt 2299561 agcactaagg cgcttttcat gccataaagc ttccccatcg caatgtcaga ttcaatgctg 2299621 tctcctataa tcatgcattc atgtgcggac agccccattg ctgtacaggc agcctccgcc 2299681 atcagccatg acggttttcc gacaacaagt tcagtcttcg cttgtgcaga agtctcaatt 2299741 gccccgatca ttccggccac atcaatggca tttccgtctt cgttcggaaa agagcggtct 2299801 ttgtttgtag cgataatacg agcgccgccg gcagccgctt gaaaggcttg atttaaatcg 2299861 tcgtacgtga gcgtttcatg aagggagatc acgagccaat ccgcttcctt cggttcgctc 2299921 gcgttctgca caccggccag cctcagctcg tcaaccaagc cttgctcccc aagcacccat 2299981 acctttgaaa aacgataatg ttttttcaga aaagccgctg tcacgcttga tgacagaaca 2300041 atgtcgttta cgtccgtttc aatccccgcg ccaagaagtt tttttctgca catggcacgg 2300101 gagatattcc cccggttgct taaaaagacg attttctttc ccattctcct aagcgttttg 2300161 atcgcttctc ttgctccttc gatcaactca tttcctctga atacagtacc gtccaagtca 2300221 atcagaatgc cagccggtga cacaggcgta tcatgactgg ccataatacg catttgctcc 2300281 gtgttttcga taaaaatgct tttcatgcag gactgtattg attggggtta catccttgtt 2300341 cagcataatg gagtgatagg ccatttcggc aaccgtttct aatacaactg cgttatgaat 2300401 ggcatttaag gcgtcagtgc cccagcagaa cggtccgtga ttattcacga gcacacccgg 2300461 cacctgttcg taattatgat gctgaaaggt ttccgctatg acttttcctg tattcagttc 2300521 gtagtcatga atgatttctt catcgtacat ttctcgagta catggaatcg cactgtcaaa 2300581 ataatcagca tgggtcgtgc ctaacggagg gatgtctctg cccgattgcg cccagcttgt 2300641 cgcccattga gaatgggtat ggacaattcc cccgatattc ggaaaggctt tatatagata 2300701 aacatgggta ggtgtatctg aagaaggttt aagcgagcct tcgacgacct ctccatcaag 2300761 gttcaaaaca accaagtcat cggctgtcag gtcgctgtat tcgactccgc taggtttgat 2300821 gacaattctt tctttttcac ggtcaatgcc gctgacattt ccccacgtaa aggttaccag 2300881 ctgatgctct tgaagcttca ggttggcagc cagcacttct ttttttaatg tttcaagcat 2300941 gctccatcac cctttatcaa ttctttttgg cggcagatga aaattgaaga tttttgatcg 2301001 ttttcagacg cttcatgaca tggttttctt ttccgaaata atgaaccagc tctttatatt 2301061 cagcgtacaa tttttcataa accgcggcgt tttcggcatt tggcgtataa gttatatctt 2301121 tcagttttcc catgttcgcc gctgcctttt tgatatcatc gtagccgcct ttttctttgc 2301181 ctgctgcaag cgcgccgaaa atggcagatc ctaaggctgg ggcttgcggt gaaccagaga 2301241 ttttaatgtc catgtttgtc acatccgcat aaatctgcat gacaaacggg tttttctcag 2301301 ctattccgcc ggctgcgaac agttcctcaa tcggaacacc gctttctttg aatgtttcga 2301361 taatcatccg ggttccgtaa gctgtcgctt caactaacgc tctataaatc tcttcaggct 2301421 tcgtcagcag tgtcatgcca agcagcatcc ctgttaaatc tgcatcaaca agagttgaac 2301481 ggtttccatt ccaccaatct aaagcaagca agccgctttc accaggcgct tgatggtttg 2301541 ctttctcact cagcagctca tgaacgccaa tgtttttttc ctttgcttcc tcttgataag 2301601 ctggcgggac acatgttttc acaaaccagt caaaatgatc gccgacacag gactgcccgg 2301661 cttcatatcc cgcatagccc gggagaattc cgttgtccac aacgccgcac attcctggaa 2301721 cgatatgcac ctcttcacca agtagaacat ggcacgtcga ggttcccata atcatcagca 2301781 ttttccctgg ctctgtaatg ccgaccgccg gtaccgaaac atgagcgtcc acattggcaa 2301841 ccgcaacagc cgttcccggg agaagccctg tcagctttgc cattttttca gtcagactgc 2301901 cggctttttc tcctactgaa tgaatagaac ctgacaattt gtcctttgta atcgttttca 2301961 ttgaaggatt taatttctca aagaaatcat ctgacggata ccccgctttt tcactccaca 2302021 tcgctttata ccctgcggta caattgcttc gcttgagcga gccgcacagc tggtacacga 2302081 tccagtccgc agcctcgatg atccggtcag ccgcttcata aatgtgaggc gcttcctcgg 2302141 caatttgcat gacctttgga atcatccatt ctgatgaaat ttttcctccg taccgctgta 2302201 aaaaagcctc tccttcttct tccgcgattt gattgagccg atcagcatgt ttttgggccg 2302261 catgatgctt ccagagcttc acatagctgt gcggctcctc ttcatattca ggcagcatgc 2302321 ataacggctg cccgctgctg tcaataggaa ggatcgtaca tgccgtgaaa tcaattccaa 2302381 tcccgataat gtctttcggg tcaacgcccg tctgttcgag taaagacgga atggttgttt 2302441 ccaagacttc gaggtaatca gcagggtgct gcagcgccca gtcacgcggc agcttttgac 2302501 ccgtttttgg aaggacggta tcaatgacag catgcctgta ttcttttaca gcagccgcaa 2302561 gttcctcccc tgtttggaca tgaacgagca ctgctcttcc tgataaagtt ccaaaatcaa 2302621 cccctattgt gtaagccatg tgacatcccc ctctactttt gaagccggta aagcgcctcg 2302681 ttccatttta actcgtgttt cagtttatga attgtcgtat cacgggaaat gagaacactt 2302741 tcgattcccg ccatttccgc ccaatcaagc atttgctccg ctgtcagttc ataagacagg 2302801 caggtatggt gtgcaccgcc ggctaaaatc catgcctccg ctgctgtttt caatgacggc 2302861 tccggcttcc agagaacacg ggcaaccggt aaattcggca tgtctttttc aatttcctgg 2302921 ccgttgactt cattcagcac aaggcggaaa cgcccgccaa tatcaacaat gctagcttga 2302981 atggcagaac cgctgatgcc gttaaatacc aaacgcgcag ggtcctcttt gccgccaatc 2303041 gaaagcgaat gaacctcgat tttcggctga tccaaagcga cagtcggaca cacttcaagc 2303101 atgtgagagc ccagaatcat ttcatttccc ggttcaaaat ggtacgtgta atcttccatg 2303161 aaggaagttc tttttccttt agccatgatt ttcatcatcc gtacaagggc cgctgtcttc 2303221 caatctcctt caccggcaaa cccatagcct ttctccatca ggcgctgaac ggcaagtccc 2303281 ggcagctgtt tcattccgtg cagcacttca aacgatgtcg taaacgctgt gtatccgcct 2303341 tgctcaagaa aagcggttaa tccaagttca attttcgcct gttctttaat ggacgctacc 2303401 tttgcttcgt cacgttttgt ttcctcactg atcacatata gtctgtcata ctcggcataa 2303461 agcgtgtcaa cctcgtcgtc cgtaatgcga tccatcactt caacgagatc cccgatgcca 2303521 tatccgtcaa cctgccagcc aaattgaata tgcgctccca ccttgtctcc gtccgttacc 2303581 gcgacatgac gcatgttatc tccaaatctg gcaaccttaa tatgtctgct ttcatttaat 2303641 gcagccgccg tatccatcca ctgggacatt tcttttttca cttcttcatc atcccaatag 2303701 ccggcaatga cttttcggct aagccccatt ctcgagttga tgtaaccgta ctctcgatcg 2303761 ccatgcgcgg attggttgct gttcataaaa tccatgtcaa tcgtacccca cgggatatcg 2303821 cgattatatt gggtatgcaa atgcataagc ggtttttgat aagaggaaag gccttctatc 2303881 cacatttttg caggggaaaa tgtgtgcatc catgtaatga tgccagcaca tgtctcactg 2303941 tactccgctt ctcttaacag ctctctaatg gtttccggtg aagtgacgac gggcttatga 2304001 gtgattttat atctggaaga aatcccgctg agcccctcac aaatgctttt agcatgctga 2304061 tctacgagtt ccagcgtctc ttccccgtat aggtgctggc ttcctgtcac aaaccagaat 2304121 tcataatcct ttgtctgaag catgtaaact gcccctttct cataaaataa aacgctttca 2304181 aatacaaaag atacgtacta atgatagaaa ataaacctat aaataaatat ttgtacgaac 2304241 aattttatta tagtaattga ctattatact gtcaatcttt tcttttaaaa aaagccgggg 2304301 gcagagcccg gctttttaat tcaataggac ggccagcccg agctccaatt caaatcattg 2304361 atgagaagct ttggaatgcc gttgtcattg gcatcatagg catggcgaac aagaatgttt 2304421 ccgttcacaa tatcctggcc tccaggtcct ttccattggt cattgcccga atccaaaatg 2304481 gtgcctccgc cttcaagcat gctttttccg cttttatcaa gataagggcc tgtaatgctt 2304541 ttggatcttc cgtaagcaat tttgtacgta ctgtttaccc cgtcacagca tttatcaaat 2304601 gaaaccatta aatagtaata tccattttga tacgtaagag taggagcttc taaggcacct 2304661 ccattattcg gtctagctgc aatcgaatag agcgagcctg taggcttcat tgtactctta 2304721 tcgagcttag tcagcttaat gccgctccaa aacgagccga atgcaagcca cgggttgcca 2304781 tccttatcga atgtcagctc cggatcaatg gcgttataat tatttgagct tgtcgaacgg 2304841 atcaccaagc cctcgtcctt ccagcccccc gaactgatgc ttgttgaaga tgccaggcca 2304901 atggcagatg tattgcttcc aaaagaagaa acggaataat atagccagta cttgccgtta 2304961 tagtattgga tgtccggcgc ccactggttt tggccataat tcggcacata attggaccac 2305021 cacgatagcg gtgtagtgaa aatggatttt tgtacggtcc aatttttagc gtctgaagac 2305081 ttcaaaaccc gcagtccccg ttcttcagta agccctgttc cgagcgcata ccatgagctc 2305141 ccctctttaa tcatagtcgg gtcatgaagc agctcattgg atgcacccca aaacgctgcc 2305201 tctgcgggag cagcagaagt gaatatcaaa cctgcagcca gagctgcact cgaaaagtgt 2305261 aagaagcgtt tccatgtttt tttctttttc aattttgttc aacctccttt attttagaaa 2305321 gcgcttacaa attagattat ttatcctccc ttcctgtcaa atcgactgcg tatcgtatat 2305381 cgtcatgttc aggaaatttt cggtatcccc tttattgtag tcactatgct gtaatttgta 2305441 cagacaaaaa aatagaatcc acctcaatag gcggattctt ccgtatcttt attggtacgt 2305501 aatttcgtca accgtttttc ggtctaactt cttaatgact tctgtaatta actttaccgc 2305561 gttttcataa tcatcacgat gcagcatggc cgcgtgcgta tgaatgtagc gggttgcaat 2305621 ggtaatggac agcgcaggaa cgccatttgc cgtcaaatgg atggcacccg aatcagttcc 2305681 gccgccggca atggcatcaa attggtacgg aatgccggct tcctccgcag tggctacaac 2305741 tgcatcgcgc aaacctttgt gagagaccat ggatgcatcg taaacgataa tctgcgggcc 2305801 tttgcccatt ttgctctgcg cttccttctc ggaaatgcca ggcgtgtctc ctgctatccc 2305861 tacatcaaca ccaaacgcaa tatcaggctg aatggtgtgt gcagccgttt tcgctcccct 2305921 cagcccgact tcctcctgca cggttccgac gccatacact atatttggat gatctgtgtt 2305981 ttgtaagttt cttaacacat caatagcaat cgcacagccg atgcggttgt cccaggcctt 2306041 tgcgagtagg aatttttcat tgttcatgac cgtaaattca aaatgcggaa cgatcatatc 2306101 tcccggaagt acaccccact ccaaggcttc ttcccggctt gaagctccaa tatcaataaa 2306161 catgtctttt atttccactg atttttttct tgcttcagga gacaaaatat gaggcggctt 2306221 agatccgata acccctgtga tttctccttt ttttgtgaca atggtgacgc gctgagcaag 2306281 cataacctga gcccaccagc cgccaacggt ttgaaaacgg ataaagcctt tatctgtgat 2306341 ttgtgtcacc ataaagccga cttcatccaa atgtccggcg atcataattt tcgggccgtt 2306401 ttctgcacca gttttttttg caattaaact gcccaggcga tctgttgtca cctcatcagc 2306461 aaatggttct atgtatgatt tcatcacttg ccttacttct ctttcattgc ccggtatgcc 2306521 ttttgcatct gttaaatctt tcagcatggt caatgtttca tctaattttg ccatgttcca 2306581 aaccctcctt catcagtcct gcattcttat tatacaaaac atggcgctaa ccatacgact 2306641 atttcacttg aaaatcgggt atatgttttt acagctttct tttagaaaaa gtgaaacctt 2306701 tttctatgct tttcgtatta catcagatca tcaccataag ggaggtgcct tcacacaatg 2306761 tttgtcatgg ttctaaggat tattttgctt gcactttttg cttattgtat ttatgccgtg 2306821 gtcaaatatg tcgcgaatcc taagagaagg cttaagctgg cccaatcaaa agaacatttt 2306881 tatattattg atgaacaaaa caatacccgg aagaattttc agctgacgta taaaggcgtg 2306941 ctttttgagg gagaaaagca tattccttcc aaggatcatc cgctgtttat tcacacgatc 2307001 tttgtctgga cagaatctcc tgagaagctg aaacatttct ctgcaaaaga ttttgagaac 2307061 attgaagaaa aagtgctgga acgatatcca aattgtaaga ttgactggga ccagcccatt 2307121 aaactcgcaa aaaaagcaga agagcgttaa acgcttttct gctttttata aatcaaacgg 2307181 gctgtagtaa atagcgatga gaatcgcttc tattaccaga agaagcggta ctccgtactt 2307241 aaaagaagcg tgtttcgttt tatgtctgaa ggtttgcatg ccaagccaga caccgagcgc 2307301 tccaaacacg atggctatca gccacagccg gtcttcagaa attctccact tgtgctgctg 2307361 cgctttgcgt ttgtcaatgc ccatcaccca aaaaccgcac agattaatca acaccaaata 2307421 agcagcaata atcatgttgc ctcatccttt atatagaaaa agccgctctg ctggagagcg 2307481 gctctatatg attacttgtt taattgagct ttagcagcat cagcaagctg attgaatgca 2307541 gtaagatcgt ttacagcaag atcagcaagc attttacggt ttacttcgat accagaaagc 2307601 ttaagaccgt gcattaaacg gctgtaagaa aggccgttca tgcgagcagc tgcgttgata 2307661 cgagtgatcc aaagtttacg gaaatcacgt tttttctgac gacggtcacg gaaagcatag 2307721 tttccagatt tcatgacctg ctggttagct actttgtata atgtatgttt tgaaccgaaa 2307781 taaccttttg ctaatttaag aaccttttta cgacgcttac gtgtaacagt tccgcctttt 2307841 actcttggca ttgaatttcc ctcctaattg ttccttatcc gattacttga tgttagcaag 2307901 catttgtttg atacgtttga agtctcctgc gcttacaaca gcactcttgc gaagcttacg 2307961 cttttgcttt tgagatttgt tggcgaataa gtgacttgtg tacgcgtgag aacgttttaa 2308021 cttcccagaa cctgtctttt taaaacgttt agcagatccg cggtgagttt tcatttttgg 2308081 catgggattt cctccttatt gcttttcgtt tttcggtgcg agcattaaga acatgctgcg 2308141 gccgtccatt tttggttttg tttcgactgt cgcaacctca gcacatgctt cggagaaacg 2308201 gtctaataca cgctgaccga tttctttatg agtgattgcg cgtcctttaa agcggataga 2308261 agctttcact ttatcgcctt tttcaaggaa tttaatcgca ttgcgcaatt tcgtgttaaa 2308321 gtcatgctca tcgattgtcg gacttaaccg aacttctttt aagttaatga ttttttgatt 2308381 cttgcgtgct tctttttcct ttttctgctg ctcaaatcgg aacttaccgt agtccatgat 2308441 tcggcagaca ggcggttttg cattcgctgc aactaacaca aggtcaagat ttgcgcggcc 2308501 ggcgatttca agtgcttcct gacgggactt gattccaagc tggtcgccat tttgtccgat 2308561 taaacggacc tcacgtgcac ggataccctc attaaccaat tgatctttgc taataatgag 2308621 ccacctccat agtttcttcg aattgattca caactcattt tgaatgcatt ttgcaggcaa 2308681 acaaaaagtg tgggcattat aaaacaccca cactacgaac atctgtatca ataaaaatgt 2308741 acggtcaacc tgccaactac atgcatgtgt caatcaggtg agaagcgggt gcttctgctt 2308801 gtgatttata ttcaattcaa taactattct acacaatacc ggatctttag tcaaggacga 2308861 cttatccgga acaactttta cattgtaaca tgggttttct atgagcgcaa gagagaaaaa 2308921 gaaaatcttt catccccacc cagaatacaa agaaccaaca attccccctt attacgcaat 2308981 ttacaacaaa accaccgaca ggaagaaatg taaaacaaag ttaatctctg accgatataa 2309041 ggagcagaag ggagcctgac acatgaacaa actgatacag cttgctttat ttttcacatt 2309101 gatgttaacc ggttgctcga atagcagcac atcttccgaa tcaaaagtcg aaaccactgt 2309161 taagacaacg gcagcatttc ctcaaaagga gctggagaaa gagctaaaaa aactaaaacc 2309221 cgtttcattg gacatgaagt tcgagagtcc actcgctacc gagttaggaa agcggaaggc 2309281 aaaagaggaa gctgaaaagc aaagacaaat cgccgctgag aaaaagcttg aaaaagagcg 2309341 ggaggcgaaa cgaaagaaac agcaggagga aaaagcggag agacagcgat tagcagagca 2309401 gcaggctgca gagagacagc gattagccga agcggaaaga caagctgaac ttgaaagaca 2309461 gcggcaggca gcaatccaaa aagagcagaa agcgaacgct gagaaaaagc ggcaatcgca 2309521 ggcacaacgg cagcagactg aggcaccctc atctaatagt caagatccac catcttcctc 2309581 gagtcagaca gataaaacca ttcaacagcc agcttcagag cttcctgatg acgatggtta 2309641 tggttatgaa gaacgaaaaa agtggcatga cgatcaagta gaatggggca ttaaacaagg 2309701 gtatatcgat cccgaagacg caccataaaa taaaaaaagc caaggcattc agccttggct 2309761 tatcctccga tcagctgcac gaacacaggg atgaccagaa ccgttaccac tcctactacg 2309821 acaacagcaa tacttgccat cgcagcttca acttctccca tctcaatccc gaccgctaca 2309881 ccaagtgcat gtccggatgt tccaagagcc aatcctttag aaatcggatt tttcacttta 2309941 aacaccttca agaacaatgc tccgagcgca tatacgatga cagcgttaaa gatgaccgca 2310001 aaggctgtga tgtcgctgat gcccccgatg ccttttgata aaggaagcgc aattgccgtt 2310061 gtagccgcct gcggaagcat gcttttcatt acggccgaat cgagatgaat gcctttagcg 2310121 agcagataaa caatcgtgac agagcagata gagccggcaa taatggaggc catgatttgc 2310181 caccagtact ttttaagctt atctctttgt ttgtacaaag gaattgcaaa tgcgatcgtt 2310241 gccggttcaa gaaaaaactt aatgatctct cccccgttat tataatccgc gtaggaaaaa 2310301 ccgccgattt ttaaaaatgc gatccccagc accatggcaa caaacaaagg agtgaaaagg 2310361 aagaagcctt tcgttttctt aaataaaaag gtgccgatgc cgaatgcagc aagtgatacg 2310421 acaatcccaa aataaggact cattgtgctt tccatgtgaa gaacctcctg tttcccttaa 2310481 tggtgaacga gttcgttatt gttctgcggg ctttgcactg tttttgtttt catgtccgct 2310541 tcggttttgc gttttccgct cagcgacaga atcagctgag aaaacaatcc cgtagccccc 2310601 agcaaaataa tcgttgcgag cagaatgaca agaacaattt gcaggccgta ttgctgcatc 2310661 acaccaagcg aattcataac agatatacct gatggaacaa ataaaaatcc gatcagagag 2310721 gttaaagacg ttccgagcgt ctccacttgt tccagtttaa tgactttcaa acataatagg 2310781 agaaataata agaccaaccc tacaaccgat gccgggatag gtattgggac aatagcggca 2310841 atcatatttg aaaccagcat aatgacggca aaaataaatg cttgtgttaa aaacccgtac 2310901 acttttttag cactcatttt cttcacctct ttctctttgg taccctcatt ataaataaga 2310961 attccctgtt ataaagcgct tacaagataa catgccgtat agcgggtctg agttgcagaa 2311021 tcaaatggct gaaatgcaaa aagccgccca tcaaatatgg agcagctttt tcaattcctt 2311081 cgcatatgtc cggctgaccg gtattttcga tccgtctttc atgatcagat tatacgttga 2311141 attaaaccat ggctgaattt ctttaatata ttcagtattc acgacaaagc tccgatggac 2311201 gcggataaaa tcagaatccg gcagcttttt ctcaatcaca acgagtgtat cgctgaccgt 2311261 ataagaatga tcgaaggttt ttacattgac atgaccatct tctgttccgg catagataat 2311321 gtccttcgta tccacaatca caatcgattc ccccacagat agcgcgagct tgtgctggcc 2311381 ggcatggctg ttttgctctg tttctacaat atcccgattg acttttttat attttttcag 2311441 cgtttgctga attctttctt catcgaaagg cttggttaaa taatcaagag cgtccacctc 2311501 aaacgctttg agcgcatact ggtcatacgc tgtcgcaaac acaatagcag gaggatgctt 2311561 cattttcttc aatcgctttg cgatatcaaa accgttttct ccggataaat caacgtctaa 2311621 aaacagcaaa tcaggttttt gatccatcat ttggtcaaaa gcggattcga tattttccgc 2311681 ttcattgatt tccatttcat cattggtccg cttaagcaag taagccagtt catcccttgc 2311741 cagcatctca tcatcaacta ttaacaccct gagcatgttc ttctccctct ttcatctgtt 2311801 gcattggcac ttgaaaggaa acctctgtcc ctttatgaac ctcactgctg atatgcagtg 2311861 cagcctgctg tccgaataaa ccgatcagcc gctgatttag gttataaagc gctgtaccgg 2311921 ttccctcctt agacggaaac ggtttcttcc ccagttccgg caagacgtcc ggcggaattc 2311981 cgcgtccgtt atccgccacc ttcatataga cggatgcatc atcagataag acacagactg 2312041 taaccttgca tatgtcttgt tttttcggaa acgcgtgccg aagcgcgttc tcgacaagca 2312101 cctgcaaaac aaacggaggg atttcaatct gctccagtct gctgtcgata ttaagctcaa 2312161 ttttatattt cccgggaaaa cgcgcctgtt ctaatgacaa ataggcgtta agatggttca 2312221 gctcctttga gagcggaatc agcagctgtc tcgctccttg aaggtttgaa cgaaaataaa 2312281 cactgagctg caataggagc ttacgggttt tttcaacatc tgtacggcat aacgcagaaa 2312341 tcgtgttgat cgcattaaat aaaaaatgcg gattcacctg tgcttgaagc gctttaattt 2312401 cagcatcctt gagaagtttg ctttgcagct ctgcttcccc aagctcaagc tgtgtcgaaa 2312461 acagcatggc cagcccctcg gcaagttcct cctctacctg actcaggcct gccgggcttt 2312521 taaagtacat ttttaaggtg ccgattgtat tgccgttcga tgtcagcggt aggacaattg 2312581 cagcgtgcaa agggcattca gcatgcgtgc attcaatctc ttcctgcgaa atcgccttca 2312641 taatatgccc tgttttaatc acctttttgg acaggccggt gatcaagctt ttcgatggga 2312701 tgtggtgatc cattcccgca ccgacatgcg caaggatctt ttctttgtca gtgagagaca 2312761 ccgcatctgt tcctgtcagc ttatggataa tagccgctac acttttacag gagttttcat 2312821 ttaatccttg gcggaaaaat ggaagtgtct gatcagcaat cgtaagcact cgatgcgttt 2312881 cgagagccct tgcctgttct tccttgcgaa tgatcgcttg aataatagac agaaaaataa 2312941 aactgcctgt tccattgatg agtatcatcg gaattccgat catgctgaca agctcccaag 2313001 cgtcactgaa cggctttgcc atcagcaaaa taatgatcat ttgcagtgac tccatgccga 2313061 ttcccacaag agcggcgatg cgcggtgtcg gcattcgata tcgcttcgta aaatacctgc 2313121 cgatcaagcc tgcaagaaca cccgctaaaa tagatgagac ggcacagctt aaggccgtgc 2313181 tgccaccgag tgaaaaacga tgcaggcccg caagtatgcc gatcccagcc cctacaaaag 2313241 gacctccgag aaggcccccg atttccacgc ccaaaatacg ggtattcgcg atagagcccg 2313301 atggatctat cgtaaacacc cagtcattgt ttacaatcat atttctttga atttcgatgc 2313361 ctgtataatt gctgatgatg ctgaaaagag aaaaaataga aattaaaatc gcttttcctt 2313421 tatagccgtc ctgattctga agagcttgtc tgaaaagttt cgtatgggcg agaatgaacc 2313481 ctaatataac aataatcccc actctctcca gcatcataat cattaaatga atcattcatg 2313541 tcacctgttc tttccgtttt cattctagca tgttttcgtt ttgcggctga ctgttttttt 2313601 aaaatcgtct gaaaacatat ttcacaaggc ttttatctat tgtaaaataa aacatgagcc 2313661 ttttggcaga aagatttgaa tctgaagcag aggagaagat catgaaagcc gtattttttg 2313721 atttagatga tacactactt tgggacgaaa aaagcgtcag aacaacattt gcagaaactt 2313781 gcttacaggc ggagaaaaaa tatggccttg cccctgagga attcgaagca gctgttcgcg 2313841 aagcggcgag agaattgtac atgtcatatg agacgtatcc atatacagtg atgatcggca 2313901 ttaacccgtt tgaaggactg tggtccaatt tctcagagcc aatcagtgaa ggctttcaaa 2313961 agctgaacaa gattgtgccg gagtacagaa gaaatgcatg gaccaacgga ctgaaagcgc 2314021 ttgggatcga tgatcctgca tatggcgaat acttgggaga gttttttgcg gcagagcgca 2314081 gaaagcgccc gtttgtatat gatgaaactt ttgctgtact cgatcaatta aaaggcaagt 2314141 atgaattatt gcttttgaca aatggcgatc ctagtctgca aaaggagaag cttgccggcg 2314201 tgcctgagct cgctccttac ttcaatgaaa tcgtcatctc gggcgcattc ggcaagggca 2314261 agccggatgt ttcaattttt gaacactgcc ttaagctgat gaatattgaa aaagacgatg 2314321 ccatcatggt cggcgataat ttgaatactg atattttagg cgcttcaaga gccggaatca 2314381 aaaccgtttg gatcaaccgg actgataaga aaaacgaaac tgacgtaaag cctgattaca 2314441 tcatcagcag ccttcatgat ttgtttccta tattagagaa ataaaaaaag catgatctct 2314501 tcaatgagat catgcttttt tattttattt tttcgcttca gctactgcct ttttcacaaa 2314561 ctcatcaagt gaaatggttt cagagttctg ttctccgtat ttacgcacgt ttaccgctcc 2314621 gttttctgct tcttggtcac cgaccaccag catgtacggg attttttgca tttgcgcttc 2314681 acggattttg tagccgattt tttcatcgcg gctgtcgact tcaacacgca ggccttcaca 2314741 ttgcaggcgt tcctgcactt ttttcgcgta gtctaaatgc acagccggag aaaccgggat 2314801 gacttggaac tgaaccggtg caagccatgt cggcagcgcg cctttgtgtt cttcgattaa 2314861 gaaagcaaca aagcgttcca ttgttgaaac gacacctctg tgaatgacaa ccggacggtg 2314921 ctgcttgccg tcctcaccga tgtatgtcag gtcgaaacgt tccggcaata agaaatcaag 2314981 ctgaaccgta gacagtgttt cttcttttcc gatcgcagtt ttcacctgaa catcaagttt 2315041 aggtccgtag aatgccgctt caccttctgc ttcgtaatag tcgtggccga tttcatccat 2315101 tgcctctttc agcatggatt gcgctttgtt ccacatttca tcgtcatcaa aatatttctc 2315161 tgtatcttcc ggatcgcggt aagacagacg gaatgtgtaa tcacttaaac cgaagtcttc 2315221 ataaacatcc tggattaaac ggactgtacg gataaactca tccttaattt gatccgggcg 2315281 cacaaagatg tgtgcatcat ttaacgtcat tccgcgtacc cgttgaagtc ctgacagcgc 2315341 acctgacatt tcatagcggt gcatcgttcc aagctctgca atacgaatcg gaagctcgcg 2315401 gtaactgtga atgtcttgtt tgtaaatcat catatggtgc ggacagttca tcggacgcaa 2315461 tacaagtgtt tcattgtcca tttccatcgg agggaacatg ccttcctgat aatgatccca 2315521 gtgtcctgat gtttcataca gctctttgct gcctagcaca ggtgtgtata cgtgctcata 2315581 gccgaggctg atttctttat cgacaatgta gcgctcgatg acgcggcgga ttgttgcgcc 2315641 ttttggcagc caaagcggca ggccttgtcc gactttttga gagttcgcga acagctttaa 2315701 ttctttgcca agctttctgt ggtcgcgttc tttcgcttct tctagcatac gaagatgctc 2315761 ttcaagatca gcttttttga agaaagctgt accatatacg cgctgaagca tttggttttt 2315821 gctgtcaccg cgccagtatg cgcctgcaag gcttaacagc ttaaattctt tgatttttcc 2315881 ggttgaagga acatggacgc cgcggcacag gtcaaagaat tcgccttgct catagatcga 2315941 aacggtttct ccttcaggaa tcgcatccaa tagttcaagc ttcaggtcgt cgccgatttc 2316001 cgcaaaacgg gctttcgctt cttcacggct gacttctttt cgaacgatcg gaaggttcgc 2316061 attaacgatt tttttcattt ctttctcgat tttcggcaga tcctccggtg taatcgcttc 2316121 gtccatttct acatcgtagt aaaaaccgtt ttcgataacc ggaccgacgc cgaatttaac 2316181 atccttgtag atgcgtttaa tcgcttgagc cagcaagtga gccgcactgt ggcgcataat 2316241 ttgaagacct tcttctgagc cttctgtaat gatttccact gtaccgtctt cattgatcgg 2316301 cgttctcaaa tcgatttctt ttccgttcag ttttccggct aatgactttt tctttaatcc 2316361 cggactgatg gatgccgcga tatcttctgt tgttgttcct ttcgcaaact ccttgactgc 2316421 tccatcagga aatgtgattt ttaccatatc tgacatcttt gtcactcctt tttttgcata 2316481 taaaaacccc gccccctatg aaagggacga ggttgaataa acggaatcgt ggttccaccc 2316541 ttttttccgc aaagccaata cacggcacct gcggctctaa gctctgtaac gggagttccc 2316601 gtcagccatt actgttcctt ttcaagaggt tcacagctga agttcaaagg cggtaaagcg 2316661 aatggtcctt agctgggaag cttgcagcca gggcttccct ctctttgagc cggtatcatt 2316721 ccttcgtgtc cttatcaata cgtgtgtctt tcttaatctc ctatgtatta taaattgttc 2316781 aatccaaaaa atcaacacga tcgcgtttcc ttttttttaa accgacagcc ttaaatagac 2316841 aggctgccgg ccctcatcct tccgagtgct tcaccggtat ttctgcatct gtaaaagcat 2316901 gcagcgggag catttccact ctctcttgaa atacgttttg aatggtcctt gccatcatgt 2316961 gctcgggctg gtcggtataa agcacgactt catcaggcgc aatggaaatc agcggcgcga 2317021 gcaaatgaga atcaatatac ataggatgat cccggacaaa tcttctgtct atgtatttca 2317081 ttttttcccg ttccggcaca tagcgcagct cccataatgt aaaggaacca tcatggacaa 2317141 tatgcacttt tttgattcgc ggctgtttgg cgtccacata gtctctgagt gtttgaataa 2317201 agttttgata ttcctgttcc atcttatatt catcaatcgc tgcttctgta atatctctca 2317261 gctgcttata gtatgatcca agtcggaagg tctgaaagga gcgaatgtaa aatactcctt 2317321 cctctaaaca gatcgtttgg agttcatcca aaattgattg tttccgtgaa agcttcagcg 2317381 gctcaaacgg aagatcgtct gcttcacctt caataatact gtgtgcgagc tgaaggattt 2317441 gctgctgttc atcctggtcc gtgaaacaat acgtttcctc aatcaatgac agcatatgct 2317501 cgtcttcttt gcattccaaa aaaaatttga ccagaatcgg ctccataaaa cgctgaatag 2317561 gaaaagccgg attcgctttt tcaatcccga tttttcgtat gccttcacgg acaatgatat 2317621 tgttccgatc gtccgaatgc tgaatgagat gtaaaaaagc ggctgcatca tggtcatctt 2317681 caaagattat ttcaagcatg tttgtccccc cttacggcat ctgttacaag tatatggggg 2317741 atgtttttaa aatagacgta aaggtcattg gcaaatctta atttgattct tggaacaagt 2317801 tttgcatttt ctttctgaag atgaacggca atgagataaa cacgatatac aaagcgagca 2317861 ccataaagaa agcgggcaga ttgccagcca aaaagctcgc acccagcaca ttaagcgcaa 2317921 tcgtcccagg gatgattccc acagccgttg cggcaaaata cggcagcgct ttgacattgg 2317981 aaaggcctgc cgcatagctg acgaaatcaa aattgatcgg caggattctc aaaagaaaga 2318041 tatagaaaaa tccgttatcc tccatttgct tctgtatggc ttcaagcctt tcgtaatgcc 2318101 cgttcttttt cgccgaaaac aaaccagccg caaaaaacga aacagctgaa gcgcacatcg 2318161 aaccgaataa cgtataaagc gtgccgagaa gcgggccaaa cgcaagtccg ccagctattg 2318221 aaataacaga caccggaaat aaaacaagtg gcctgacgat ggatatcccg ataaacatca 2318281 gaggtgcaaa gactccgaac gacaataccc ataccctgat ttctttcggc gatacattca 2318341 aatacgtttt atttccccaa tagagtaaac cagcacctgc aagcactgcc agccatttga 2318401 cagccgtttt tcgtttcata ccctcagttc cttccccttt gaaccacagc aattatggat 2318461 gtcggcggtt ttctccgtca aggcggatcg gagcagccaa atataatatc cgctccatta 2318521 atcttgcagc ttttacttct tctttttctc ccctctgcga atacgtaaaa tgatgcttca 2318581 gctcgtcagg tgagaaatta gaagaaaaga acgttggcag ctgctgggac attctgtgct 2318641 gaagcaccgt tccgatgacc tcatccctta cccagcttgt cattgattct gctccgatgt 2318701 catcaagcat taatacgggt gtggtcttta ccatattgag cttctcttcc aatgtctggt 2318761 cttgcagcga attcttaagc tctctcacaa attcaggcac ataaacaatc atggaggaat 2318821 actctttttc cgccagctca ttggcaattg cagcgagcat aaacgttttt cctaccccaa 2318881 atttcccgta taaatataat cctttccctt ttcccgtctc attatagctt ttcaggaagt 2318941 ctgtaacatg ctgaaacatc gcgagtctgc ttgggtcact gatatcaact tgctggaacg 2319001 tcgctccaag aagatcctgc tggatataca tgcttttcat aagagactgt tgtttcttct 2319061 gctggtcgag cttccgtttg actggacatt cgtaatactc gatatcaata gacctcccat 2319121 tgacaacaag cttcggatgg tagccctcca acaaattgtt gcagttttca tcttccgaac 2319181 aataggagca attcttgctt tgttcgatat attcataaag cttatttaag ctcttttcga 2319241 tcattttttg gtcaatcact tcttcgtttt ccttcaaaaa tgcttgaaca tcttgatctt 2319301 tcatgacttt ttccttcatt tgttcaagac gtttttggaa atccggcctg ccggttacgc 2319361 cctgcaggga acggccgatt ggttccatct attccttcac cccgcatctc tgtctttaat 2319421 aggcagagta ttttttcagt ttttgcattt cttccatcat ctttttcttc tgttcttcca 2319481 aatcctgcgg atgcagcttc tgctgtccgg attctgaatc ggacgctgtt tccttttctg 2319541 tcatccaatc aggaagcttt tcttcacgaa tcactttttg gtttcgtttc gaagactttg 2319601 tttttccctc agcccattca agatactggc ggttttcttc tattgcgagc ttcatcgctt 2319661 ccctgaccgt tttcaccttt ttgcgtgccc aatgcgaagc gattttttgg atatagtttt 2319721 tcgacagctt catgtcggtt ttcagcatga cataataaat taacacattt gtgacgcctg 2319781 gctcgagctt ctgttcgaac ataatttctt ctatgatctt cagatcagct tttgacggct 2319841 ctgttccgtc agcaatgtcc tgcagaagct tcttcgggga aatcgcctcc agcaatgcaa 2319901 tcagcttccc atccagagaa tcctcttctg ccggttgttc gccttcacgc agatgcaccg 2319961 gctgtgtttt ttccaccaaa tcgggcagct gtccgtttct ttcaatttga taccagtcgc 2320021 tcgccgcttt tcttaatgcc tccgtcgtaa tgacgtcacg ctcatcaatt gcgctcatca 2320081 caacattttg catttgcaaa gggtcaattc cgtacagata agaaagcttt ttgattgtgt 2320141 cccgcacctg ctgggtcatc gcttttctcg gtatcatcgt ctcagaaagt cccgctaaaa 2320201 acaaatcaaa atcaaacaca tcctccgtta tggtgtagga cggagactgt ccgacagaag 2320261 tatactcgga cccctcggca agccttaccg tttcctccat atcggatgtg agcttccatt 2320321 cactcggctg cagcgattca aacgcatgat taaacggacg cgtaatgtcc ttcgcatctt 2320381 ctgaaatggc cgggtgcgta aaaaattgtt ttaattgctg atatttcgtt tttccgaccc 2320441 tattatacag aaaaacattc agcattccgt cttcaaaaaa ttcatttggt ctgagcggcg 2320501 gaaggagttc atatataaag aggcgctcct gccgctcgga ttctttcata tatactttca 2320561 gcaatccgat gccctcgagc ttcccctgtt cctgatggat cgtttttaag ttggactgtg 2320621 tcatccccat cagctgtcta tgtgtggact ctccgcccca cagacggttt tgttcaagct 2320681 ctccccacaa tgtcatataa agagagaatg caacagggcc gattaagggc tggtacagtt 2320741 gtgtaataat ttgtctgtca atatcctgca gcatcgatct gcttttaacc acatacgggt 2320801 ctacaggcag tacatctttc caatagtcag ccatacattc tcaaaccttc cgaatttgtt 2320861 tctacctttc attttacacc gtttcttata tctatcaaat gccaattttg cacatgagaa 2320921 aagagctaga agaatcctct tagctctttt aacgctcttt ctttattaag tcttttaatt 2320981 catcgataaa gacgtttata tctttaaact gccgatagac ggacgcgaac cgcacatatg 2321041 cgacttcgtc aatcttagcc agccggtcca tgaccatttc tccgacgagc tcactcttca 2321101 cctcggagca gccttgattg cgaagttctt tttcaatatc aaagcacatg tcttcaagcg 2321161 ttttgagtga aacaggcctt ttttcacatg cttttatgag gccgcgcagc attttttctc 2321221 tgctgaattc ctcacgcaca ccttcttttt tcacaacgat gagcggggtt tcctccactt 2321281 tctcaaaggt cgtaaaccgg tagtggcagg attcgcactc gcgtcttcgg cgaatcgact 2321341 ttccgtcatc cacaggccgt gaatcaagga ctcgtgttcc gttatgctgg catgaaggac 2321401 atttcaataa aatcagctcc caactatatc gttccctgca atgtattttc ggcagcctcc 2321461 gccttttaaa aatagatgtg acagcatctg tcgggagagc cgttgttaaa tttgtttcta 2321521 tagcattagg tggtttgtga aaatctcctt cttattttac aaaaaaaatg aaaaaagaaa 2321581 aagctgacac tctcgtttct ttataaaaat aaaaggagca taagctaaaa agcgcataat 2321641 ggctttctag cttcagctcc ctttgtgttc gcaatttact ttatagtact ttcgcttgcg 2321701 cctgtttaat ttgcacaggc cccattcctc ttggtatttc aatgttttct cttgtatcag 2321761 catgtaatgc ctctgcaatg taatcagcag cgacattagg atctaagtct ccacaagtat 2321821 aaacatcaat gctcgcatat ccgtgctcag gaaaactgtg aatcgttaag tgtgattcag 2321881 aaataatcac aactccgctt acgccttgcg gtgcaaattt gtgaaatgca acctcgcgca 2321941 cctcagcacc tgattttaga gcagcattta caaacgtttt ttcaataaaa tccatgtcat 2322001 tcagcttatc aaaatcgcat ccccatagct cggagataac gtgacgcccc attgtttcca 2322061 tagtcatgga ccccccttaa caagaattaa aaagtgaaat tccaacaact gggtcggcca 2322121 tttaccacgg gggaaagtta gtccggagag gtcctaaccc tttaagtaat tccgaaacag 2322181 tctcaagcaa gaagttcacg aaaaatagta tactgtgttt aagtctaatt tgcaaggtgc 2322241 gttttttcag aaatatgctg ttaagggttt tttctttaaa atgtgtccat gaccttattt 2322301 tatacagcag acggatgttt cattcgtgcc gctacatggc ggattagatc aacaactctg 2322361 caggagtagc cccattcgtt gtcataccac gccagcacct ttactttcct gtcttccatt 2322421 accattgttg taagcccgtc aatgaccgct gaatgcggat tcgtattata atcagtcgaa 2322481 acgagcggtt catctgagta atcaagtaca ccgtacatcg acgttttggc agcgcgttta 2322541 aatgcctcgt ttacttcttc agccgtaaca tccgttttca gatcaacaac gagatcaacc 2322601 aatgagacgt tcggaacagg gacacgcaag gcgaggccgt gaagttttcc tttcagatgc 2322661 ggcagcacaa gcgaaagcgc ctttgccgct cctgttgttg ttggaatgat ggattcaccg 2322721 caagcccgcg cccggcgcaa atctttgtgc gggttatcaa tatttttttg gtcattcgta 2322781 tacgcatgaa ctgtagtcat cagaccgctc tcaatgccaa actcttcatc cagcactttt 2322841 acaacaggcg caaggcaatt tgtcgtgcat gacgcatttg aaataatgac atggcgctca 2322901 gcgtcgaatt ggtcctcatt tacgcccatc acaatggtaa cgtcttcatt ttttcccgga 2322961 gcggtcaaaa tcactttttt tgcacctgct tctatatggc ccatcgcttt atctttagca 2323021 ttaaacttcc ctgttgcttc gacgactatg tcaatatcat attcccgcca aggcagctgt 2323081 tttggatcac ggctgtttaa caaaagcact ttctttccat ttacgatcag gctatcttca 2323141 ccagccacaa cctctttgtc gtatctgccg tgaattgtgt catactttat taaatgagcc 2323201 agcgtttctg cggaatagct ggcgttaatg gccactactt gaatttgatc gtctaacatc 2323261 gcttttctaa aaaccattct tccgattctt ccaaacccgt tgatcgctac ttttaccttc 2323321 atgttggaca ccccttatca attatgccat cctaatttgt tactatctaa aattagtata 2323381 acacattaaa acaaattcgc cagtacatat tgataaaaat caacgattat aacgctaatt 2323441 tatgatgcat cttatgtttt cttgcacaga atatcaggcg taagaaccaa aaagcagcca 2323501 gcgctccgca ctgactgccc tcatgcttta tgattcctgt tttaacttat cattgagcac 2323561 actttcttct agcacagaaa atgtatcccc gtacactctg ttaatatgat tcgctcccca 2323621 agcacacagc atatctaaaa tcccttctaa gctgcggccg tattcgctga gctcgtattc 2323681 cactttggga ggaacttgat tatatacgat tcggttaatg acaccgtccg cttccagctc 2323741 gcgcagctgc tgagtcagca ttttttgcgt gatattgggc attaggcgtt ttaattcact 2323801 tgtgcgtttt tttccgtgcg tcagatggca taaaatgacg catttccatt tcccaccgat 2323861 cacttcaaga gtcgcttcaa cagaaatgtt atattttttc ttctccatac aatccattct 2323921 cctcacaggc accaaaaagt gactatagca cttcaaagta cgtactttta tttcttaacg 2323981 atatgtttca taatcacatt tgccggctga tttgaatctg ctctttttta tttatatagc 2324041 ttactcggca gaatttcaat catacaacac atcttacaaa ggaggaacat catgacttca 2324101 gccaataaaa gcaatattcc tgcactactg gctttggccg taagtgcatt cgcaataggg 2324161 acaactgaat ttatcagtgt cggccttttg ccgctcattg ctgatgacct ggatattccc 2324221 gtcacgacag caggattgac cgtttccctt tatgcgctcg gcgttacatt tggggcacct 2324281 atattaactt cattgacctc aagcatgtca cgtaagacac tattgctttg gatcatgttt 2324341 atttttattg ccggtaatac gatggcagca accgcttcaa gcatcgggat tttactagca 2324401 gcacgtgtga tatcggcatt ttcgcacggt gtgtttatgt cgatcggttc gacaatcgca 2324461 gcggatattg tcccggagga taaaagggct agcgcgattt caattatgtt tactggcctc 2324521 actgtggcaa ctgtaaccgg agttcctttt gggacattta tcggccagca gttcggctgg 2324581 cgtttcgcct ttatggtcat tatcgccgtc ggaatcattg ctttcattac aaatggcatt 2324641 cttgtaccgt ccaaattacg aaaagggacg aaaacaacga tgcgggatca attgaagctt 2324701 gtgacaaaca gccggttatt gcttttattt gtcattacag cgcttggata cggaggaaca 2324761 ttcgttgtgt tcacgtatct gtctcccctg cttcaggaag taacaggctt caaagccggg 2324821 actgttgcag tgattctgct cggatacgga atagctattg ctatcggcaa tatgattggc 2324881 ggaaagctgt caaaccgaaa tccgattgcc gctttattct atatgtttat cgtacaggca 2324941 atcgttctat tcgtactgac atttacagcc ccgtatcaag cagcagggct cattaccatt 2325001 ctctgtatgg gattgctggc ctttatgaac gtgcccggcc ttcaggtgta tgtcgtcatg 2325061 ctggctgagc gttttgtccc gagtgcagtt gacgtcgcat ccgcgatgaa tatcgctgcc 2325121 tttaatgcag ggatcgcgct tgggtcatac cttggcggtg tgatcaccga ttcaatcgga 2325181 ttgattcata ccgcttggat aggcggatta atggtggtcg gtgcagtcat tttaacaggc 2325241 tggagccgct tgatggaaaa acgagatcgg caggaagcct gacaatttta aaggaggaaa 2325301 taaacatgac aacacattta caagcaaaag caacacttca taatggggta gaaatgcctt 2325361 ggttcggcct cggcgtgttc caagtggaag aaggatctga actggtaaac gcagttaaaa 2325421 ctgccattgt tcacgggtac cgcagtattg atactgcagc aatctatgga aatgaagctg 2325481 gagtcggaga agggattcgg gaaggcattg aagaagcagg catttcaaga gaggatctgt 2325541 ttatcacatc gaaagtatgg aatgcggatt taggctacga agaaacactc gccgcgtttg 2325601 aaacaagtct gtccaaactc ggtctggatt atttggatct atacctcatc cactggcctg 2325661 tagaaggaaa gtataaagaa gcttggagag cgcttgaaac gctgtataaa gaaggccgta 2325721 tcaaagcgat tggcgtaagc aacttccaaa ttcaccatct tgaagatctg atgacggcag 2325781 ctgaaattaa gcctatgatt aaccaagtgg aatttcaccc gcgcctcaca caaaaagagt 2325841 tgataagata ctgccaaaat cagggcatcc agatggaggc ttggtcacct ttaatgcagg 2325901 gacagctgct ggatcaccct gtattggctg acatcgctca aacatataat aaatctgtcg 2325961 cacaaattat tttgcgctgg gatctgcagc atggcattat aacgattcct aaatcaacga 2326021 aggaacaccg cattaaagaa aatgcaagcg tatttgactt tgaattaacg caggatgaca 2326081 tgaaccgaat cgatgcactg aatgaaaact tgcgcgtcgg tcctgatccg gacaactttg 2326141 atttttaatg gccaaaaaac accgttcaat atgaacggtg ttttttgtat tatgcccagc 2326201 tgttcatgat ttcatcaagc tgccttttgg tctcttcaag cgtgccgctg ttatcaatga 2326261 cttgatctgc tcttgctgtt ttttcctcta agggcatttg agagcggata cggctgactg 2326321 cttcttcttc tgtcagctga ttgcgcttca tcagacgttc cagttgaagc tcttttgtca 2326381 cactgaccac aataatttta tcaaccaatg attccaattt gctttcgaac aatagcggga 2326441 tatccaatac aacaaatgcc tcccgatttg caacggcttc atcacggcga ttgagcattt 2326501 cctgcctgac tgcgggatga acaattgcat ttaaagcgag acgtttttgt tcatttgtaa 2326561 ataccagcgc tccaagcttt tttctatcta tatcgccatt tgagagcagt atgtcttcac 2326621 cgaattcgtc aatgatttgc cggtaggccg gcatcccttt ttctaccgct tgttttgcaa 2326681 tgatatctgc atctataact gttattcctt tttcaatcag catattggct accgtgcttt 2326741 tgccgctagc tattcctccc gttaaaccaa tgactaaggt caagagatcc actccttttt 2326801 acaatttcca gagcccaatc gtgattaata gaagccccgg caaaaacgcc attttatcga 2326861 tccatttcca cttagacaga aaatggccgg cattgattcc aattgataca aacagcgagc 2326921 tcatgattgc cacggcgatg ctcatcacaa tcggcgaaaa accgagaatg gctgcgccta 2326981 tacctgctcc aaaggcatca atcgataagg caaatcccaa taagaccgcc tcaattccgt 2327041 tgatcacacc cgatttgtcg atatccgcac tcatgggttt tctcaaaata tgaatcacaa 2327101 ttcctaatga ccgaacctct agattaagca gtgttttttc atgcaatagg tattctttat 2327161 cttttgccgg tttgaaaaat tgatacagaa cccacgcacc gattccaacc aatatcaaac 2327221 cgccaagctt ctccgtcaca tatacaggaa aaaacttcgt gagaaagctt ccgatcagca 2327281 tggatataaa catgacagca ccggaacagc aggcgataac caaaatcgct ttaaacggta 2327341 ttttcatttt tctcaatccg tacgtaaatc cgactgaaaa actgtccaag ctgacagcca 2327401 acgccagcag cagtatagaa accatttgca tatccgtttc ttcctttctg ttggtgctct 2327461 tgtatcagat gtgaaatgcc cgggattcat cacaatcata tatatgggaa agtgaaaaat 2327521 ccgtgtttcg aaaatggcat ccttaatcca gagttactga tatatgcacc gacagcttgg 2327581 acaatgaagc attatgctac ttttttgtct ggcactttgc gcaaaaatgc gtgcctcttc 2327641 ctccaacgac aattttcgaa atcatcgttc cgcaattttt gcatggctcg tctttttttc 2327701 cgtacacaaa atgctgcagc tggaacattc cgatttcccc ttgggagttg atatatgaac 2327761 ggactgtgct tccgcccgca tcaatcgcct cctgcagagt gtttttgatt tcagcgtgaa 2327821 gggttttgat tgttttatct gataattgat ttgcttttgt ctcgggatgg acacccgctc 2327881 tgaaaagagc ctcatccaca taaatgttcc cgagtccaac taccgttttt tgatccagta 2327941 gggcagtttt gacagcgcgg tttgttttcg caagccggtc ttttaaatac gcacttgtaa 2328001 attcttctgc atccggctcc ggccctaact gagaaagcgg gagctcgccc gcttcttctc 2328061 ccggtttaaa taagtgcatg gttccaaatt tccgcacatc cctgtaccgg agctgggttc 2328121 catccgtcat cgtgaatatg acatgcacgt gtttatcgtc aggctcctcg gcttgatgaa 2328181 gaccgtattt tccttccatt cgaaggtgag aaaccataac ataatgatct aaatgaaaca 2328241 gtaaaaactt tccccgtctt ccgatggact gtatcgtttc tcctgctagt tttcgcgcaa 2328301 attcctccgg ttcggcaggc cgtttgatga tattcggcca tctgatctct accgatttga 2328361 ttgtttttcc ctttacaagc ccggtcagag tgcgccggac cgtctcaacc tctggtaatt 2328421 ccggcacatc catcacttcc tatctctgtt tatttcgcat cgtaccaaga tgggcctgat 2328481 gcaaagtcca cctttaacgg cacatctaat gcaagcgcat gctccatcac ttcaggaaca 2328541 agcttttcaa gaatttcaat ttcttccttt ggcgcctcaa aaatcaattc atcgtgtact 2328601 tgaagcagaa gccttgcttt caactgtttt tctttcagct tggcagccat gtcaatcatg 2328661 gcttttttga taatatcagc ggcgcttcct tgaatcggcg tattcatggc cgtccgctcc 2328721 gcaaaacttc ggatattaaa gttccggctc gtcagctcag ggatgtagcg gcggcgatgc 2328781 ataagcgttg ttacgtatcc tttttgtttc gcttcctgta ctgaatcttc catgtacgct 2328841 tttacgcctt ggaagctttc cagatagcgg tcgataaatg ctcccgcttc cttccgggta 2328901 atgccgaggt tctgtgacag accgtaatcg ctgatcccgt aaacaatgcc aaagttgacc 2328961 gctttcgcct ggcgtctcat cgcagatgtc acttcatcct tagcgacatg gaacacatcc 2329021 attgccgttt tcgtgtgaat atccatatca ttagtaaaag cttcgatcag attttcatcc 2329081 tttgaaatat gggcaagcac ccgcagctcg atttgtgaat aatcggctgc aaaaatgagc 2329141 cagtcttttt cagacggcac aaaagcttgg cgaattttcc gcccttcctc aagcctgatc 2329201 ggaatgtttt gcaggttcgg atcagtcgag ctgagacggc cagtttgcgt taaggcctgg 2329261 ttaaatcgcg tgtgcacttt atgcgaatcc ggtctcgtca cctttaaaag cccttcgata 2329321 tatgttgatt gaagcttgcc aatttgtctg tactgtaaaa tatagtcgac aatatcatgc 2329381 ttgtcagcca gcttttcaag cacatcggca gacgtagaat agcctgtttt cgttttcttt 2329441 acgacaggaa ggccgatctt ttcaaataag atgacgccta gctgtttcgg agaattgatg 2329501 ttaaacggct ctcccgcaat ctcatggatt ttttcttcat attccttcag cttcgcaccc 2329561 agttcttcac ccatccgttt taaacggtca acatcgacct tgacgccagt tgattccatt 2329621 tcgccaagaa taagcgcaag aggcatttcc agctcttcaa acagttcaag ctggtcgttg 2329681 ttttccagct cttgaacgag cttttcccga aggctttgaa tcgctaacgc ttttcggcca 2329741 aggtgctcag acagtacgtc ttctgacggc actgcccgtt ttgctccttt tccataaact 2329801 gattcatcac ttgaaacgat atgcaggccg taatccttag ccacactcgc aacgtcgtca 2329861 tatgaattgc ccgggttgat gatataagcc gcaaggagcg tatcaaactc ggctcctttc 2329921 agctcaatgc cctgccagcg caaagcgaca acggcccgct tgctgtcgaa gacccatttc 2329981 ttctgctcgt cattttccac ccattcttta aacacctcag actcaacggc aatgtctttc 2330041 ggaatgaaat aagctcccgt ttcatttacg atcgaaaatc cgaggatcgg ctcttcatga 2330101 taattatcgc caatctgttc aacgacaaat gcggatggag aaaccaatat atcgcttgtc 2330161 acgtctgtga ctgttttgac attaatgtct tccaacgatt gatcctgttc tgcttctgca 2330221 ctgtcttctc caagccgttc aagaagcgtg ttgaagccaa gatctttaaa gatggcaatg 2330281 acctgttcac gattaaagcc ttgatattcc aggccggaaa cagatacctc aatcggagca 2330341 tccgtcataa ttgtcgcaag ctccttgctc atcaatgcct gatccttaaa ctcctcaagc 2330401 ttttccttca atttctttcc gctcacctcg tcaatggact ccagcagctt ttcaacggaa 2330461 tcaaattgtt ttaaaagctt aatcgcagtc ttttctccga cgccgggcac acccggaata 2330521 ttatctgagg aatcgcccat cagacccttc atgtcaatga tttgttcagg cgtaagccca 2330581 tatttctctt tgacatgctc cggtgtgtaa aattcaacat cggtaattcc ctttctcgta 2330641 atggcaactg tcgttttgtc cgttgccagc tgggttaaat ccttatctcc tgagaaaacc 2330701 ttaacttcaa atccgtcttt ttcagccgat ttggccagtg tgccgataat atcatccgct 2330761 tcatattgtt ccagttcata gcggctgatc tggtaggcat ccagcagctc gcggataaac 2330821 ggcatttgtt cggaaagctc aggcggggtt ttctgtctgc cgcctttata ttctttaaat 2330881 gtgccgtgac gaaatgttgt tttcccggca tcaaacgcaa ccagcatgtg cgtcggtttt 2330941 tcatcctcaa gcattttcat caaaatcatc gcaaagccgt atacagcatt cgtatgaaca 2331001 cctttatcat tgcttaacag cggcaatgca aaaaacgccc ggtaagccag actgtttccg 2331061 tctacaagca ctaatttttt tcgttccgtc attcaatttc ctcctaagaa gcctcaggct 2331121 tccattcatc tcttacatag tcattagctc ctcttatttt aacaaagttc aatttgaaag 2331181 gaaaatacgt gaactataag agaagacaca aaaaaggacg ggaacacaaa taggttcccg 2331241 ccgtcaaaat tggctccttg gatgaagggg ttctactaca tcctaccagc ataggtttaa 2331301 cagtgcatga agatattgtt aaacctttgt aaacattagg cggacttttc agcggcccgt 2331361 ttcagcgtca cggtaaagac agttccccgt ccaagctcgc ttgtgacatc aattttccct 2331421 tcatgagcct ctattaaatg cttgacaatc gctaggccca gcccggttcc gcccgaattt 2331481 ctgcttctgt ctttatctac acggtaaaag cgttcaaaga tgcgcggaat ttcttctttc 2331541 tgaattccga ttccagaatc ggcaacctca atctgaatgt ctttttctct gggctttaca 2331601 ttgatagcca cggagccccc ctcaggcgtg taggttaatg cattgtttac gagattaaga 2331661 aatacctgtt tcagcctgta cgggtcacca gatacatatt gagggtcttt cgggacattc 2331721 aggtgcaagg agatgccttt ctcatccgcc ttatgcttca gaagcgtttc aatctcacca 2331781 agcattttgg ccggctcaaa cgtttcgata ctgagcgtga aattttgctg ctcgattttt 2331841 gagagatcga gcaaatcctg aaccaaagac tgaagccttt cgctttcctt aagaataata 2331901 gagagaaatt cagaaagcgc ctctttgtct tccatcgccc cgtccaataa cgtctccgta 2331961 aaccctttta tggacgtaat cggtgttttc agctcatgag aaacattggc cacaaaatcc 2332021 ttcctcatct gctctaattt cttcgtttcc gtcatgtcat ggaaaacgag cacaattcct 2332081 ttccattcat cgtccggccc cataatcgga acgccgtcca cttcaaaata acgccgttct 2332141 attttgatcg gcagtcttaa cagcttgcat ttctttgtct ccgtcataaa aatgtcttcg 2332201 acaagctgga tcacttcttc atgttcaaat gcatcgtgat aaagacggcg cagcatatga 2332261 ttcggattga tatgaaactg cttggcgtaa gacctgttta cgagattaat aaagcctctt 2332321 ccgtcgatca taatcagccc ggagccaatg ttttcaatga ctgtcagcag ccgatcccgc 2332381 tgcatttcct gcgttcgcgt catttccatc agatcaatgg caaggctgtt catcgcatgt 2332441 cctagcttat cagaacgcct aatatagccg ccgtacgtcc gtgcatcgta gttgccctta 2332501 gagagttctg tggctacatt tgtcgctgac tcaattgacc ttttataacg tgaggtcatg 2332561 ctggaataaa aataaacaat gacgataaat gcggtacaaa gactggccgt cagcatcccc 2332621 cacaattcgc cttttaagcc gtcgcttttt tcagaggcgg aaagcagcac atatcctgtt 2332681 ttttcacctt cgcttctaag tgaaagtccg taataaagct tgttatctgt tgttgacaga 2332741 ataccctcat ggccagaaac aagcgcctgc accttttggg aatcagccga tctaccgttt 2332801 gacccataca gcaccttacc gtctgtatcg ataacggatg cgctcacatc aagcgcgccg 2332861 cctgcatctt taatgatttt ctcatttgct tgattattca gattgccggc atcaagaagc 2332921 gaagccaagt attttgcttc tttttcaatg tgttcctctg ctttcctttg atcagatgtt 2332981 tcaaaaagct gctgtaaaaa cagcccgagg acacaaaaca ccagaatcat acagacaacg 2333041 aatacagaaa aaaggcgcac acggtattta ttcattcatt tttggctcct ccagtttata 2333101 ccccaatccc ctaatcgttt taatgtagat cggttttttg gtattgtttt caattttgtc 2333161 gcgaagatgg ctgatgtgca catcaacaat tctcgtatct ccggcaaaat cataattcca 2333221 gactgcgctc agcagcaggt ctcttgtcag aactctgcct ttatgtctgc ctaaatagag 2333281 cagcagttcg aattctttcg gtgtcagttc aagctgactt tctttaaagt acgcttcata 2333341 atgatcaggc aggattttca gatcgccgat tacgatctgg ccttccattt catcgttctt 2333401 catctcacta gagggcgcag ctatttccga acgccttaaa atcgctttga ctctcgcatt 2333461 tacttccctt ggactgaacg gcttggtcat ataatcatca gcaccgagct ccagccctaa 2333521 tactttgtcg aattcctcat ccttcgctgt cagcattaaa atgggaaaca tcagtttttg 2333581 ctgtctcagc tgcttgcata cttcgattcc gtccaatttt ggaagcatca catcaagcac 2333641 aatcaaatca ggtttctctg tttccgcttt tttgagtgct tcttccccat ccgaggcggt 2333701 aatgacatca tagcctgacc gttccaaatt gtactgtaaa agagtaacaa tagattcttc 2333761 atcatccaca actaaaattt tcttgttcat gctgtgcctc cagtattata attccccgac 2333821 atcctatttc tctattttat gtcatcttaa catgtttcat gattttattt tagcgaaagc 2333881 aggacattcc gacaattcgc cttttacatc atttttaaaa gaaataaaga cgtttatgat 2333941 agcgctttca tttatagtaa aaagagaaag gctgtattaa gcaagccttt ctctcttttt 2334001 attaggataa tactttcatg acatttttga cagattcaac tgatttattc agctgcgctc 2334061 tttcatagtc tgtcagttca agttcaatga tttgctcaag accgttgccg cctacaattg 2334121 taggaacacc aaggtagatg ccttcatagc cgtattcccc ttcaagataa gcaattgtag 2334181 gaaggacgcg gcgctgatct ttcaagatcg cttcgaccat ttctgtcaga gaagccgcag 2334241 gcgcataata cgcgcttccg tttccaagaa gattcacgat ttcgcctccg ccttttctag 2334301 tgcgctccac aattgcgtca atccgttctt tcggaataag agtttcaagc gggataccgc 2334361 cagcataaga ataacgcaca agcggaacca tatcgtcacc gtgtccgccg agtacgaaac 2334421 cagtcacatc tttcactgac aggtttaatt cctctgccac aaatgttctg aatcttgccg 2334481 tatcaagcac acctgactgg ccgattacac gctctttagg gaagcctgat tctttgtaca 2334541 ccgcgtatgt cattgcatca acaggatttg tcagcaccac aataatagag tcaggagaat 2334601 atttcacgat ttcctgcgta acgcttctca taatcttttc gtttgtagag accagatcat 2334661 ctctgctcat accaggtttt cttgcgatac cggctgtaat gacaacaatg tcagagccgg 2334721 ctgtatcctc gtaattggat gttcccgtaa tttttgcgtc aaagccttga accgggcttg 2334781 cttcaagcat atcaagcgct tttccctttg tcgggttctc caattgcgga atgtcaacaa 2334841 gaacaacgtc tgccagctct ttttgagcga ttaaaaatgc agttgtagct ccggtaaaac 2334901 ctgctccgat aacagaaact tttttacgag tatttcccat gtctctcttc tcctttatgg 2334961 ctagttttag gctttttcct tgcttagtcc atgtttttga tcagttcttc tccgaactct 2335021 gaacatttca cttcagtcgc cccgtccatt aatctggcaa aatcgtaagt tacgacttta 2335081 gaagcgattg ttttttccat agatttgata accaaatcag ccgcttcgtt ccatcctaaa 2335141 tgctcaagaa gcagaacgcc tgaaagaata actgaagatg ggtttacttt atcaaggcct 2335201 gcatatttag gagccgttcc gtgcgtcgcc tcgaaaatcg catgtcctgt ttcgtagttg 2335261 atgttcgctc caggagcaat gccgattccg ccgacttgcg cagcaagagc atcagaaatg 2335321 taatctccgt tcaagttcat tgtcgcaacg acatcaaact cgtttggacg cgttaagatc 2335381 tgctgaagga aaatgtcagc aatgctgtct ttgataatga tttttcctgc tgcttccgct 2335441 tcgctttgcg ctttgttggc agcgtctttt ccttgttctt cagcaatgcg gtcatattga 2335501 gcccatgtga agactttatc tccgtattct ttttcagcaa gttcatagcc ccagtttttg 2335561 aaggcgcctt ctgtgaactt catgatgttt cctttgtgaa caagtgttac agatttgcgg 2335621 ccatgctcga tcgcataatc aatggcagct ctgaccaagc ggcttgttcc ttcttctgaa 2335681 acaggcttaa tgccgatacc tgatgtctca gggaaacgga ttttattgac gtttaactca 2335741 ttttgaagga agctgataag cttttgcact tcttcagagc cttttgcata ctcgatgcct 2335801 gcgtaaatat cttctgtatt ttcacggaag atgaccatat cagtatcttc agggcgtttt 2335861 accggtgacg gcactccagt aaagtatctt acaggtctta agcagacgaa taggtcaagc 2335921 tcttgtctga gcgctacgtt caaagaacgg ataccgccgc cgacaggtgt cgttaacggg 2335981 cctttaatcg cgatgaaata ttcgcggatc acatctaatg tttcagcagg gagccactca 2336041 cctgttttat tataagcctt ttctccggcg taaacttctt tccatgtaat tttcttttcg 2336101 cctttgtatg ctttttctac tgctgcttcc aaaaccttcg aagccgcgtt ccaaatatca 2336161 ggaccggttc cgtctccttc gataaatggg ataatcgggt tgtttggtac gtttaatact 2336221 ccgttagaga ctgtaatttt ttcaccttgt gccacaataa aaacctccca gtatgtaatt 2336281 catatttaga aaacatttta tttttcttat atagaaaata aaatgatttt tcctaacatt 2336341 caatttaaag tgtaacccaa ttttgatgtc tgaacaagag gctaacctca ttgacgcaag 2336401 ccagcctcca atggttcttt aggctctttc ttcaatcgga acgaattttt gtttgtcagg 2336461 gcctgtgtaa tctgcccgcg ggcggatcag acggttgttg tcatactgct caagaatatg 2336521 agcgagccag ccggacattc tgcttacagc aaaaatcggt gtaaacaaat catggtcaat 2336581 accgaggctg tgatatacag aagccgaata gaaatcaacg ttaggcggaa gctttttctc 2336641 tgatgtgacg atgtcttcta tacgaatcga catctcatac catttgcttt cgcctgtcag 2336701 gttggtcagg cgcttgctca tttctttcag atgcttcgcg cgcggatcac catgcttata 2336761 cacacggtgg ccgaatccca tgattttttc tttcttttca agtttagcgc ggatgtacgg 2336821 ctcagcgttt tccacttcac cgatttctgt cagcattttc ataacgcctt cattcgctcc 2336881 gccgtgaaga ggccctttca gcgcgccgat tgctgcagta atgcctgaat agatgtcaga 2336941 aagtgttgcg acgcagaccc tcgctgtgaa cgttgacgcg ttcagctcat ggtcagcatg 2337001 taaaatcaat gctttgttga aggcttcaac ttcaattggt gaaggctctt caccgtttaa 2337061 tgtgtaaaga aaattctccg caataccgta atcttctctc ggttcaacag gctcaagacc 2337121 cttgcgaatt ctggaaaacg ctgcaaccag gccaggcacc tttgcctgaa ggcggatcgc 2337181 ctttctgtag ttggcttccg ggttcatggt atcagcctcg ctgtcaagca ggcctagtaa 2337241 tgaaattgct gtccgaagag cagccatggg atgaacattt tcgagggaat aagatttgaa 2337301 gtgctcaata atttcttgcg gaacggcagc ttcctttgca agctgctgct ttaactcttc 2337361 aagctctttt ttgtttggca gccttagatg ccaaagcaag tagatgattt cttcaaaact 2337421 tgcattctct gtcaaatcat cgatatcata ccccacatat gtaagggtat catcaataat 2337481 agaactaaca gatgatgttg ttgctacaac cccttcaaga ccgcgtgtcg ctgtcatata 2337541 taacatctcc ttttcaataa atttcccctt taagagtgtt gtaaaaacat gaggcttact 2337601 taaaaagcac gatgcaagta tttctctccc ccaaaaagaa aatgcttaca ttttactggc 2337661 tgctggaact aaaacccttt gcttttgaaa gaacataaca aatttttata agcttattta 2337721 agtttaagcc tattctcatt ataaacaata atcagacatt tgttaaatgt ttacctataa 2337781 tttttttttt ccattctgtg atttccccga aaaaacgcct ttatttgcgg gtttttgcat 2337841 aaaaaaaagc ggctttaagg ccgctttttt ttatgaagtg aacagtttta cgatctgcat 2337901 ggctaaataa gcaatccccg ctccgatcag cggccccacc gcaactcctc caaaaagcgc 2337961 gactgcaaga atggtcccga tcacgagagc agttgtaata tgcggatcat tttcaagcag 2338021 ggtcaggccg ttttttgcaa tcagcgccac tgcgatcccc gctccaaggg cgatccatgc 2338081 gtaggaagac cgcattgctt ctccaagctg cttaaatccg atttctcccg tggcaatcgg 2338141 gacaagaacg gcgatggtaa taatggtcac accccagtta atgccttttg actggatggt 2338201 cggaaataat ttctgatcaa gcccaacgat tttgatgatc aaaaggacgg atacagcaaa 2338261 gagcaatgat tggttttttg cgataagtgc gatagccaag agtaaaatta aaaataaatt 2338321 cgcttgtgta aacacatgcc atccctcctt taagatgaat gtattcatat tcagccgcag 2338381 cgtgaataca tataaaaaat aggacatgct gacgagagga ggaccgtttt tgtgaatcaa 2338441 tcttatatca ctattttttt cagaaccctc tttgtcatat caatgaccgc agggtcgata 2338501 gctgcggcct attattcgtt tccgttaact tatccgttcc tgatcgccct tattctatct 2338561 tcagtgattc atcctgttgt cgattatttg gacaaagtga caggattccc ccgaacgata 2338621 aatgttctgg gcgttcttgc tttttttctg ctcgcagcct tcggcgtgct caccattctg 2338681 gtagccgaaa tcgtaacggg aacagcctat ctagcaaaaa cgctgcctcc gcatatcagc 2338741 acgtttattt catattgcga aaaattgttt accactcata ttcagccgct ctataacgag 2338801 ttaactcttt tgtttcaaga attggaaacg aaccagcagg cttccatcgt cactcatatc 2338861 cagacactcg gtgattctgc cgctaaaaat gccgggctcc tgctgtccca cattctagag 2338921 atgatcccga gatttttcgc tcttcttccc aatacggcgg cggttctgat tttttctctt 2338981 ctggcaacct tttttatgac aaaggattgg cataagctga aagccatgct tgttttaatt 2339041 ctgccggatc gtgtgacagc taacagcaaa gcaatcagca gcgaattaaa aaaagcaatg 2339101 actggtttta tcaaagcaca agccgtcctc gttttcatca cgatggtgat tgtatttatc 2339161 ggcctttctc tcttaaaggt tgaacacgcc gcaacaattg cttttttaat cgggcttgta 2339221 gatcttctcc cttacttagg tgccggctcc gtatttgtgc cctggatttt gtatttatcg 2339281 attacgggcc agctgcccca agcaatcgga attggtatcc tgtacctcgt cgttcttatt 2339341 cagcggcagc tgacagagcc caagatacta agtaaatcta tcgggatcga tccgctggca 2339401 acactcatcg ccctgtttgc cggctttaaa ttattcgggt ttttaggact gattgcggga 2339461 ccggctgtac tcgtcatcat ccaagctttc atcacaacag gcgcattaaa agaaatatgg 2339521 tcctatatca ccgttcagca aaaataaaac ggcagccgtt ttttcatggc tgccgttttt 2339581 tatttgatga tgatccgctt attcttcgac attcctctca gccatttgaa cagaatcggc 2339641 ttacaccagc cgcgggtaaa cgggataaga agacaggcgc cggccaaatc tgataaaaag 2339701 cccggaagca tcagcaatag accgccaatg aaaatgcaca gaccgtcagc aatcgcttct 2339761 cccggcattt tgccatattg aagatcacgc tgaaccttat aatacacttc ggttccttgt 2339821 ttttttgcag ctgctgcgcc gataatgcca gtcagaatca tgaatagaac tgtcggcaaa 2339881 ataccaatca gatttcctaa aaataggaat ataccgattt ctattgccgg aaacacaata 2339941 aaaagcaaaa acaaaaatct catatccaag ccccccacac gtgtaacacg ttctgttcaa 2340001 caaaaggcat gataaagaga aaaggaaggg attccccttc cattttcacc tgtaattaaa 2340061 gaacgctcgc acggccttga tagactgcgc ctctggaagc gtcaactgta atatcctggc 2340121 catctgtcaa aatagatgtc gcattttcca gacccacgat aaccgggatg ccaaggctta 2340181 atccgactac cgcagcatgg ctagtcaaac cgccttcttc tgtaataaga gcagacgctt 2340241 tttcaaggga tgcaatcata tcacggtcag tgcttttggt aacaagtacc gcaccgtcag 2340301 tcattttttg ctcagcttct tttgcatttt gtgcaacgac aaccggaccg taagctgatt 2340361 tgcgtccaat gccttggcct ttagcgatga tatcgccgac agtatgaacc ttcattaagt 2340421 tcgtagtgcc ggactcaccg acagtgccag ctgtaataac gataagatcg ccgtgtttta 2340481 caattccgct gttcaatgat ttttggacag catcctcaag catctcatct gttgagctcg 2340541 cattttggcc gctttccgcg aatacgccag atacgagggc aagctttctg gaaatagagt 2340601 catttacagt aaccgcaaca atcggagcct gcggacggta ttttgcaatc atacgtgctg 2340661 tatggccgct ttctgtcggc gttacgatcg cagcagcatt caggttaatc gccgtatgtg 2340721 cgacagattg tccaattgcg tctgtaattg tcatgcccac ttggtctctg cgttttgaga 2340781 gaatttcttt ataatttaat gcttcttcag aacgggacgc gatgttatgc attgtttgaa 2340841 ctgcttcaac cgggtaactt ccggcagcag tttcaccaga aagcatgatc gcatctgttc 2340901 cgtcgaagat cgcgtttgca acgtcacttg cttccgcacg agtcggacgc gggttgcgct 2340961 gcatgctgtc aagcatttgt gtcgctgtaa taacaggttt gcccagcgcg ttgcattttt 2341021 tgatcagttc tttttgcaca agcggcactt cttcagctgg aatttccaca cctaagtctc 2341081 cgcgtgcaac cattaagccg tcagacactt cgagaatcgc atcgatgttg tcaacgccct 2341141 cttggttttc gattttaggg atgatttgaa tatcctgagc gttgtgctct tcaagaagct 2341201 cacggatttc gagcacatcc gtagaacgtc gaatgaaaga tggtgcgatg aagtctactc 2341261 cttgctcaat accgaaaacg atgtctcgcg catccttttc agtaatcccc ggaagattga 2341321 cacttacgcc cggtacgtta acaccttttt tatttttgag tgttccgttg tttaatactt 2341381 ttgttttgat ttcgcgttta gcggcatcta catcaagtac ctcaagaccg ataaggccgt 2341441 catctaacag aatcgttgaa ccttgttcaa cgtcatggac taaaccttca tatgtcactg 2341501 aaattttatc tgttgttcct acaacctcgt ccattgaaat aatgagctct ttgcctgttt 2341561 caagctcaat accgccgttt tccattgtat gtgtgcggat ttcaggacct tttgtatcaa 2341621 gcagaattcc aacgttcttg ccaagttttt tacttgcttc gcggatattt ttaattcttg 2341681 caccgtgctc ctcaaaatct ccgtgagaaa agtttaatcg agccacgttc attcctgact 2341741 ccattaattt cgtaagcatt tcaatacttt cacttgccgg accgatggta caaacaattt 2341801 tagtttttct catttggttc acttccttct gaaatcttca gccttcagct gtacattaga 2341861 tagacagttc ttttgaaagc tgatacatgt tttgctcaac tgtgtgtttt gtctcaagta 2341921 tttctataat atcatggtct acaagcttat tgttttgtat acctacacag cgtccgcctt 2341981 ttccttcaag cagcagttca actgcatatg cgccgagacg gcttgccaac acacggtcag 2342041 cagcactcgg agaacctccg cgctggatat ggcccaatac agatacccta gtttcaagat 2342101 ttgtttcttc ttcaatgcgt ttcccgaatt caacaccgct gcctacacct tcggcaacaa 2342161 taataatact gtgcttcttg ccgcgttcgt ggccgcgttt taagcgggca atgatttcgt 2342221 gcatgtcata gtctgcctca gggattaaga tcgattctgc gccccctgca agaccggccc 2342281 acaatgcgat atcgccggca tgacggccca ttacttcgat tacatatgta cgttcatgag 2342341 aagtcgctgt atcgcgaatc ttatcaattg cgtcaattac tgtatttaaa gctgtatcga 2342401 aaccgattgt aaaatcagtg cccggaatgt cattatcaat tgtacccggt acacctacac 2342461 atggaaaccc gtgttccgtt aattttttcg cacccatata ggaaccgtct ccaccgataa 2342521 caacaaggcc ttcaatacca agcttcttca agtttgctat ccctttttca cggccttcaa 2342581 ctgttttgaa ttcaggacat ctcgccgtat aaagcttagt ccctccacga tgtataatat 2342641 cgcctactga tccgagttca agcttttcaa tctttccgct gatcaatccc gcgtatccgt 2342701 tgtaaatacc gtaaacttca acgtcatgat agatcgcttt tctgactact gcgcgaactg 2342761 ctgcgttcat tcccggggaa tccccgccgc tcgttaatac ccctattcgt ttcattctcc 2342821 attcacctca gcaacatata tgattaaaca taacatgatc attgccctaa aaacaatgaa 2342881 aagggatctc catcctccct atgaaacctt acctattata caattaaata aattgttttt 2342941 aaataaaatt taaggaatgt cacaaaaaat aaacgtgagc caaaggcttc acgtttattt 2343001 agtttacccc gatatattga tcttcaaccg agactttgcc aattgcttta tatttttcat 2343061 aacgctgctg aactaattct tcttcgctca gcttcagtaa agtttttaac gattgtttaa 2343121 gggtttcgtc catatagctt gcctgcagct tcacatcatg gtgcgctccg ccttttactt 2343181 ctttaatcat atgatctata atacctaatt cttttaaatc cggcgcagtg attttcattg 2343241 tttctgctgc ttttttagca agactggagt ccttccataa aagtgccgcg gcaccttccg 2343301 gagaaataac agaataagta gagttttcca gcatatgcaa gtgattgcct acacccagac 2343361 caagggctcc gccgcttccg ccttcaccaa tgacgatgca gataacaggc actcgaaggc 2343421 cggccatctc aaacaggttt ttggcaatag cttcactttg tcctctttct tcagctgctc 2343481 gtccagggta tgcccccttc gtatcaataa aacagataat tggtctgtta aatttgtcag 2343541 cctgtttcat cagacgaagc gcttttctgt agccttctgg atgcggcatc ccaaaattgc 2343601 ggactaggtt ttccttcgtg tctttgccgc gctgatgccc gattaccgtt acagggaggc 2343661 cgtggaactt cgcaatcccg ccgacaatgg cttcatcgtc cccgtacgct ctgtctccgt 2343721 gacattcaaa aaagtcggta aacaggtgtt cgatataatc aagagttgtc ggacggtccg 2343781 ccagacgcgc gatttgaacc cggtcccacg gcttcaaatt tttgtaaata tcatcctgaa 2343841 gcttagcgag acggtcttcg agccgttcga tttccgcact tagatccata tcggaatctt 2343901 gggtgaattt ttttagttcg gcgattttgg tttgcagttc aatcaccggt ttttcaaatt 2343961 ctaatcttgg agccactcaa tgtcacctcc tgtttgatgc atatccagca gattttctaa 2344021 cgtttttttc atatcgtcgc gatgaataac cgcatcaagc tgtccatgtt ttaataaaaa 2344081 ctcagccgtt tggaagtcct caggcagttt ttctcctatt gtctgttcaa taatccgtct 2344141 tccggcaaaa ccgatcagcg cgccaggctc agcgaaattg taatcgccaa gggatgcaaa 2344201 gcttgctgat acgcccccgg tagtcggatg cgtcattact gaaataataa gaccctgttc 2344261 ttcactgaac agttttaacg cagagcttgt ctttgccatc tgcatcaaac ttaatacgcc 2344321 ttcctgcatt ctagcaccgc ctgaagccgt aaaaataata aacggaactt tatcagcttt 2344381 tgctttttca atcgcaagcg tgattttttc accgacgact gaacccatgc tgcccattct 2344441 gaatgaagag tccatgacgg cgacaacagc cgggtgtccg ccgatggtgc ccttgcctgt 2344501 cacaacagcc tcgtttaagg atgttttctc gcgatctttt tcaagctttt ccagatatcc 2344561 cgggaaacca agcggatttt ccgagagcat tccctgatta aattcctcaa aggattgttc 2344621 atccatcaag ctttcgatac gctgttttgc gttcattggg aaatgataat cgcagttcat 2344681 gcatacccgc atatttttat ccaactcttt agtgagcatg atttttttac acttaggaca 2344741 ttttgtcata atgccttccg gaacatcgtg cttcgcttga tcagacggta cggaagcata 2344801 ctttttcttt ttcgtgaata tatcctttaa caaatgatta cctccctttt gtgaagggtt 2344861 ctcttcaccg catgtcatca aacagataga cttgctaata actttaccga aactattgta 2344921 ctttttttgt caaacgctgt catcctcaat tcgacaactt tttattcgat gacgtgctcg 2344981 gaaaggcttg tatgaaatca gataaggtgt tgaaacgaca aggttgacag cgcattcaaa 2345041 aataatgtta aacccggctg aaattttttt aaggctaacc ccctaaaaaa atttcagccg 2345101 tcagtttaac ttgagaacag cgcgccggtc tccgccaacg cgctgccatt tttggaatga 2345161 attaaaatta ttcaccaata atcgtaagtt ttcttgtttt ttctgcgact tcctcagggt 2345221 caacagtgat tcttgcaaca cctgtttcca tcgcagcttt tgccacagcc ttcgcaacag 2345281 caggcgcaac acgtttatca aacggtgcag ggatgacata gtctgcgcta agctcatctt 2345341 ctgaaaccag tgaagcaatg gcttcaaccg ctgcgatttt catttcctcg ttaatatgag 2345401 tggcacgcac atcaagcgct ccgcggaaaa taccagggaa tgcaagaaca ttgtttactt 2345461 ggttcgggaa gtcagaacgg ccagttccga caacgcttgc tccggcttca cgcgcatctt 2345521 ccggcatgat ttccggattt ggatttgcca ttgcaaagat aatcggatct tttgccatgc 2345581 tttgaaccat ttcttttgtt aacgcgcctg ctacagagac accgataaat acgtcagcat 2345641 caacgataac atctttcaga gaaccgtctt tgcgatcttg gttcgtgaac ttcgccactt 2345701 catttttgac atcgttcatg ccgttcgggc gcccttcata aatggcccct ttggaatcgc 2345761 acatcacaat gtcgcgaacg ccataatgat gaagaagctt gataatcgca atgccagccg 2345821 cacccgcgcc gtttgcgaca actttaatgg atgacatgga ttttccagac agtttcagcg 2345881 cgttcacaag acctgctacg gttacaatgg cagtaccgtg ctgatcatca tggaaaaccg 2345941 ggatgtttgt ttcttttttg aggcgctctt caatgataaa gcagtttggc gctgcaatat 2346001 cttcaaggtt gacgccgcca aatgtcggtt ccagcaattt tacagtttca acgattttat 2346061 caacatcgtt tgtgtttaaa gcaatcggga acgcatctac gcccgcaaag cttttgaaaa 2346121 gaactgcttt cccttccata acaggaagcg ccgcttcagg gccgatgttt ccaaggccaa 2346181 gcacagctgt accgtcagtt acaactgcta ccatgttccc cttcattgta taatcatata 2346241 ctttgttaat gtcttcatga atatccttac acggttctgc aacacccgga gaatacgcga 2346301 ggcttaaatc tttcgcattt ctgacctcta cttttgattt agactccagt ttcccctggt 2346361 tgactttatg caggtgtaat gcttcttctc ttaatgacat tctcctaaac actccttatg 2346421 gatatttttt gattcgtata ctgctgcgtt gattgctgca ttctgcggag taaatctatc 2346481 tgaatattta aacaggatca cataattgct ccaattgtat aacaaaaagc gaatcgttac 2346541 cactgtttta aaacgacgtt tttttgaccc aacagctctt ttaagcgata taacacctgg 2346601 tgatctgcat tgatatggaa cgactcaggt agcttaatcg tctgtttttg cctttcataa 2346661 tagagataaa cgcctgtttc ccctttatgc tccagcaaaa tgcgcttaat ctttgccagg 2346721 atctcctggc tgtgctgact gctttctatt tttatataaa ccgatggcgc tttttctgca 2346781 tccatatctt ctaataattc tgcccgggac atgatgaatt ggatcttatc ttgtctaact 2346841 tcacatttcc ccgcagtgaa caaaagagcg ccttctctta aaacgggaga aagctgtctg 2346901 aattgttcag ggaagactac ggcttccatc tcgccggttt catcactgag cgttaaaaac 2346961 gccatgtttt gacctgtttt cgtccgaatc gttttgatct tcgacagcag aacgcctagt 2347021 gaaagctgcc ttttgactgc ccgctgagcc tgcagaatgg agactgctcc ttgcgcagtg 2347081 agctgttttc ggaaggcgga gaggggatga tttgaaaaat aaatgccaag cgtttccttt 2347141 tcaaacgcaa gtaaatccac cagaggaagc tcctccgtct ccacatactt cggcttaatt 2347201 gaaaacgatt catctaaaaa caatcccatt tggtcatcgt ccgcggcgaa tagctcagca 2347261 tgttccaaag caacatcaat ggatgcgagc agcgtggccc ggttttggcc gaattcgtcc 2347321 atcgcaccag aaaagataag tgcttcaagc attttgcgat ttacgctttt tgacggcacg 2347381 cgaaagcaga aatcgaaaag atcttcaaat ggtttctctt ttcttgcttt atatatatct 2347441 ttgactgctg agacgcctac actttttatc gcgcggaggc tgtatctgac agatccgttt 2347501 tcaactgtaa acggaaaact gcttttattc actgacggag gaaggatacg aatcccgctc 2347561 ccctttgctt cgtaaagata ttgagagatt ttatcctcat tgccaatgac gcttgtcagc 2347621 aatccgcaca taaaatataa cggataatga gctttcaaat acgcaagctg gcacccgatc 2347681 atgctgtatg ccaccgcatg gcttctgtta aagccatagt ttgcgaattt gacgattaaa 2347741 tcgtagacct catttgcagt gtctacagaa tactcctttt ttaagcaccc ttcaacaaaa 2347801 tggcttcgct ctctgtccag gatttctttt ttctttttgc tgaccgccct tctcaatagg 2347861 tccgcttcgc ctaaagaaaa ccccgccata cgggaagcaa tcatcataat ttgttcctga 2347921 tacacaatga cgccatatgt atcttccaaa atgctcctta aatcttcatg aggatagtga 2347981 acaggcgccc gaccgtgttt acggtcgata aataacggaa tattttccat cggacccggc 2348041 cggtacagtg cattgaccgc cacaatatct tctaggcccg aaggtttcag ccgtttcaag 2348101 acgcttctca tccctgcaga ttcaagctgg aaaatgcctg tcgtatcccc ttttgacagc 2348161 aaggagaacg ttttgtcatc gctgtaggaa atacttgaaa ggtctatttt aatattttct 2348221 tctttttcaa tcattgaagt gatggattca ataagtgtca gattcctcaa acctaagaaa 2348281 tccattttta aaaggcccaa gtcttcaaga tggtccatcg cgtattgcgt taaatagatc 2348341 ccttcatgcc cttcttgaag cggaacaaca tctgttaacg gttcttcact caggacaacg 2348401 cccgctgcgt gggttgatgc atgccttggc agcccttcta ttttccgggc aattgaatag 2348461 acttgctgaa gcaggcttga ctcccgaagc cgcttatcca gctgcggtga ctgctgtctc 2348521 gcttcatcca gcgtcattcc cggtcttgaa ggaatgagtt ttgcaagctg atctgcctcc 2348581 ttcgggctga cgccgaatac tctgccgacg tcccggagcg ccgcctttgc cgcaagtgtt 2348641 ccaaaggtga taatctgtgc gacgtgcatt gcaccgtatt tctgctgaac atattgaatg 2348701 acttcatccc ttctagtatc gggaaagtca atatcaatat ccggcatgct gacgcgttcg 2348761 ggatttaaaa atctttcaaa cagaaggtga tgcttaatcg ggtcaacatc tgtgatatac 2348821 agcacatatg ccacaagaga acccgccgca gaaccccttc ccggtcctgt aacaatccct 2348881 ttttcatggg cgtgcttcat aaaatcccac acgatcagaa agtaatcgct gaacttcatc 2348941 cgcttgatga catcaagctc atattgaaga cggcgaaggt atcgttcatc aggcttgccg 2349001 aaacggctgc ggagtccctc catacagata tccgttaaat aatcatcagc ggacgttccg 2349061 tctggggtcg gaaaagacgg tagacgggtc tgcccgagac tgacgtcaac ccggcattgt 2349121 tccgcgatct ctacagaagc ttgcagtgcc tcgggatgct ctcgataaat gttttgcatt 2349181 tcttcgagtg gtttcaaatc gagatcaggc aaatcttcag cgggtgcatc cgtcagtttt 2349241 tcccccgctt taatcgcttt caaacaacgg taggcagcct tatcttcctt ccttatgtaa 2349301 tgcacatcgc ctgtggccgt aacagggata cccgtttctt ctgacagctt tagaatctgc 2349361 tcagacaaga cttgattccc tttaaaaggc tgataggaga aataaaaagc tccctttccg 2349421 aatatagact gaaattccag cgaggcttga gcagcctgtt cgaacagccc tccttcaaga 2349481 agcgtttcaa tatatccttt ttcgccgggc gttattgcga taatcccttc tcgataactg 2349541 tgaagccatt tcggcttcag tccgcctttt gatttagatt gcagaacgct gctgattttc 2349601 agcaggtttt gatagcctgt attcgatttt gccagcagga cgagcgggta tgcttcaagc 2349661 tcgctgtcat ctgtaaaaac agaagccgtc aaaccgatta ttgggttgat ccctctcgcc 2349721 ttgcaagctt tataaaattg aatagctccg tacatgacat gatcatctgt cagcgccaaa 2349781 gacgcatatc cgagcctgtc agcttcactg acgagttctt ccacagccgc ggcgctgttt 2349841 agcaggctat acccgctatg cacttgcagg tgaacaaaag acatgctatc acctctttct 2349901 cattacgatc catttcttcc ttcattataa ggccggtttc caaaagaaac aaatgttctt 2349961 ttttgactca tcatcatact tgtcctgaaa gctcaatatg atataaaagg tgaggtgata 2350021 aagatggatc aggaagcagg atttatggtg aattttatca atagctactt cattgcgtta 2350081 ggggtgctga tcgggggcgc actcatcgga gggctcggag catacttggc aggcgaaccc 2350141 ccgcttacag ccattacaaa gcttgccaac cggttaaaaa tatgggcgct tgtcgcagct 2350201 atcggaggca cctttgatgc ggtatacagc tttgaacgcg gcatactcga aggcaatacg 2350261 agagatatct ttaaacagct tcttttaatt atttcggcca tggggggcgc gcaaagcggc 2350321 tggcttatta tatcatggct gacccaggag catctttctt catgagggtc ccccagcatt 2350381 acaaaaaacc gggatggcag cgttttttcg cgggaatgat gtgcggagcc gtaatcagct 2350441 ggttcttttt cctgtttact tacggaacat tccaagagga gcaggtcagc ctcatcgaaa 2350501 agcaaaaaga gcatgtaaaa gacttgaaca atcaaatttc gatctatcag gaagacctcc 2350561 ataaactgaa tgaagataat aaaagaaaac tgctgattca aagcgtcagc gtcaaattgc 2350621 tgaatgggga taaatataaa atatcacagc cggataaaac gaaattcgag gagcatgtaa 2350681 aggatgatat ttcagaggtg attacaaaag acatagagag cgtctatcaa acaaaggatc 2350741 tcttgaagcg gacaattgaa aataaagtct atatgatcaa tgaaaaaaaa tacgaggcaa 2350801 ccgtcagaga attgattatt tatacgaggc tgacagtgga acttgaaatt tctttcgcca 2350861 cataattatg gatttttttt aaattctcca aacttctgtc gctttttccc attctttttt 2350921 ataaactata tgtgaggctt aatggcgaaa ggaaggagga agggaaatgg aggtttacag 2350981 tgaccgtcag ttagcaaaag atcaagcagc ccgtctcaga caaggttttt ctgcatatgc 2351041 cgaaacaaac tcactcgctt ccctcatcaa aaaagaactt caatcacaca atctccaagt 2351101 ctacgaggac cttactgatt tcggctgctg gttcatcccc gtcacagatg aacactaaga 2351161 gagagggtct cccctctact cgtgttcttt acataatgtt tccagatcag ctaaaatacg 2351221 atcagcttca tcccagctgt aaatagaggc gcctgaagct aacggatgcc ctccgccgtt 2351281 atatttccgg gcaagtccgt taatgacagg ccccttcgaa cggaatctga ctctgatttg 2351341 atcgtcttct tctacgaaaa acacccaggc gcgaatacct gagatattgc caagcgtccc 2351401 gacaagctgc gacgcttcag aagccgttgt gccgaatttt tcaagcgtat cctttttgat 2351461 gaaaacagaa gccgccccgt tttcggacaa agacacattt tgaaagataa agccgttaag 2351521 cttcaccaca ttcagttttg tttcatacaa ttgattaaat aactctgagg aagagaatgg 2351581 atactgaatg agctcgcctg catattttag tgttttttcc gtggtattcg gaaataaaaa 2351641 gcgtccggta tctccaacaa tgccggcgta gatcagctct gccgctttcg tattcagctt 2351701 ccagccgtgc tcttttcctt ctaaatacag ctcgtaaatc atttcactta ctgagctggc 2351761 gcttgtatcg acccagagaa ggtcaccgta tggatcttcg ttcggatggt ggtcgatttt 2351821 cattagtttg gcgcctgaag gataacgctg atcgtcgatt ctttcctgat ttgccgtatc 2351881 gcagacaatg acaagtgcgc cttcatatgt ttcattgtcc acctcatcaa gggaatataa 2351941 gaaagagagg gacggttcag gcgtgccgac cgcaaaaata tttttttcag gatatgtttc 2352001 acgcaggatt tccgtaagcc cacactgtga tccgtaggca tccggatcag gacgcacatg 2352061 tctatgtaag ataatcgtgt catataatga tatggttctg atcaattctg ttttcatttg 2352121 atactccttt attgttttta ttcattaaat cacattctct gccgacggaa aagaaaaata 2352181 acgtcaaaac caagcccgtt tttgtataaa atggggttgt aaacttttac gatggaggat 2352241 ttcatttatg ctggttcttg tttttttgat tgggctttca gcctgctttt atgtgtacta 2352301 taaagtaaaa ggcgtacggg caaagccatc tttggcaaaa gaaatatgtt cagcaaaatc 2352361 aagcatggcc ttagggtcac tagtcctgtt ctacgggctt aaccaaatga tattattcca 2352421 ttcagtatta acgttagtaa tcggcggtat ctttatcgtc ataggagcag gaagcgcttg 2352481 ggcaggttat aaagccttca ggcattacaa tccccttcac gccaaagaag ctgaaagaga 2352541 tcacgcgtaa ggggcgcctg aacgtccctt agcttctttc catcagctga accatcagca 2352601 tcgctttaga cacgatatga ccttggctgt gcacttccac ttccattttc ccaaactttc 2352661 tgccggcctc caagatgcga ggtttgactt cgatgactga ttccatctgc acaggcttca 2352721 aaaagaagat ggtgatgctc tctatgacga gttcgccgcg ttttttcgag cgcaaaaatc 2352781 ggtttgccgc ttgcgtcaaa atggtcgtaa atacgccata agaaatggtt ccaagctgat 2352841 ttgtcatttg cggcgtgact tcatactcgt aaaccgtttg atcttcttta tcatcaccct 2352901 catctttaaa cccccttgaa acgatatcat caagcttctc cccgacctgc ggctgctttt 2352961 gaatcatttg aagagctttc aatacgtctt ggcggctgat catgccgatg agtttttggt 2353021 ggccgtcagt gacgggaagc acttcgatcc cttcccatac catcatttgc gcagctgaag 2353081 cgacagatgt tttcccaata accgtgacgg gatttttggt catgactttt tctatagatg 2353141 catttcggtc atggccagca atatcttttg atgtcagaat gccatggatt ttcatttgat 2353201 cgtcgacaac cgggaagcgg ccgtgccccg tttcaaaatt tttctcatac catttttcaa 2353261 gtttatcctt aggcgaaaga tataccgtgc ggtcagcagg tgttaggatg tcctccacca 2353321 aaacaatttc ttttttgatc agctggtcat atattgcccg gttaatcatc gcggcaactg 2353381 taaaggtgtc atagctcgtg gataaaatcg gcagttcaag ctcatctgcc agctgcacaa 2353441 tgctgtcatc cgtgttaaag cccccggtca ccaatacggc cgcgcccgct tcaagcgcct 2353501 gcctgtgtgc attgattctg tttccgacaa tcaaaagatt ccccgctgcg gtgtaacgca 2353561 tcatcgcgtc aagctccatc gcgccgatga cgaatttatt caatgtctta tggagccctg 2353621 ccctgcctcc gagcacttgt ccgtctataa catttacaac ctctgcatag gtaagctttt 2353681 caatgttctc ttttttcttt tgttcaattc tgattgtgcc cacacgttca atcgtgctga 2353741 caaacccttt attctctgct tccttgatcg ctctgtacgc ggttccttcg cttactttca 2353801 tttcctttgc aattcttcgg acagaaattt tttcaccgac aggcagtgaa tcgatatacg 2353861 ttaaaatttg ttcatgcttc gttgccaagc ctttcacctc taaggacagt cttcttgttt 2353921 ttattataag gtttcaaagg atttatacgc aatgaggctg gaaaataaaa aagaagcccg 2353981 accggcttct tacagcgttg atttcgttcc agtcaaacgc aaggaccacg tgattccttt 2354041 tacatcgtaa agcggaaaaa cctttatttt tcttttaaat ggacatcaac cgctgtctta 2354101 acaatatttc gattccctat tttagataaa acaaataaaa ctgcggatag ccatatcgcc 2354161 cctatggccg tatagatcaa tggatgaaca gctgtgtttg cgatccattc atttattaat 2354221 gttctggcat ttaccagaat aataaatcct cctacaagca cacccatcaa ttgcggatga 2354281 aacttctgca ccagccatgc tgcgataggg gcagcgataa ttccgccggc cattagtgaa 2354341 aacacccata accaattgac gtcctcccat cctaatgaaa taagaaaacc ggcggttgca 2354401 gatacggcga tggcaaattc acttgtgtct acagtcccga caactttcct cgggctcaag 2354461 cctttgcggg ataataaaat cggagtggtc accggtcccc agccgcctcc gcctgtggca 2354521 tctgcaaaac cagcgatcac tcccaatggg atggattgtt ttcggtttaa cggcacatgc 2354581 ttcttctcaa gagccggctt atattgaaat aaaaacctga tcaatacata tccgcccaga 2354641 aggagcaaaa acaaagaaat atagggtttc gccacatctc caggtaattg gctgaggaat 2354701 gccgcgccta aaaaagcgcc tatagagccg ggaatgacaa gctgataaac ggtttgtttg 2354761 tcaacattgc caaatttaat atgcgacact cccgatgcgg cagtcgttac gacttccgct 2354821 aaatggacag aagccgaagc cacagcaggt gtgatgccaa acgccaataa caaagaagtt 2354881 gaggtaaccc cataagccat acctaacgaa ccgtctatta actgcgacaa taaaccaata 2354941 aatgcaaaaa cgattaattt cttcatcaga acaccccatc tatatcaatc agatattttt 2355001 gactcttcat tcgaatctaa caatctcttg gcgctttcat ataaaaaata agaggctttg 2355061 ataattgcag tttcatctat tgtaaatgca gggtggtgcc aatcatgatc accgtctgtt 2355121 ccaaaaaacg caaaggatcc cggaatatgc tcaagataat aagcaaaatc ttcccccgcg 2355181 gttgatgggg cgggatcaat gacttgaagt ttcgctttat gtgcagcgtc tcgcaccagc 2355241 cccgtaattg cctcatcatt acaaagcggc ggcggtccgg aatgccactt cacatttgcc 2355301 tttaacgaga aagcggcaga aatctgctct gtgactgcaa aaaaacgctg tttcacttga 2355361 ttacgaacct ctgaatcaaa tgtacgaaca gtgccctcaa tgaccactgt atccggaatg 2355421 acattccaag tgctgccgcc gttgattttc cctacggtta aaatcgcgct ttgcagcggg 2355481 tttacatttc tgcttacaat cgtttgcagg gcgacaataa gctgagaggc gccgataatt 2355541 ggatcaaaac cattatgcgg caatgctgca tgagcacctt tcccttctat ctctacttta 2355601 aatcggtcaa cagcagccat aagcgggcct gtttttaacc ctacagtccc aaccgcgata 2355661 tccggtttat tgtgaaggcc aataaccgca tcaatgccat ccagttggcc gtcctctatc 2355721 acttttgtag cgcctgcacc cgcttcctct gctggctgaa ataataaacg aatctttcct 2355781 ttcagactgt cttgattttc cttcaataaa aaggccgcac caagaagcgc tgccgtatga 2355841 aaatcatgac cgcacgcatg catgatccct ttatgtttag acgcataagg caatcctgtt 2355901 ttttcttcaa ttggcaaggc gtcaatatca gccctcaaag caatcgccgg accttctgac 2355961 tcccctgcta tgtctgcgaa cacacccgtt tttagagcag tagggcgaat ctgtatcccc 2356021 ttttctttaa ggcatttttt tataaaagca gttgtttcaa attcttcttt tgacagttca 2356081 ggatattggt gcaggtgccg gcgaatgccg atgagctgct tttctagcgt tgagagattt 2356141 acgggattag actcctcttt caacgtcagg atgtcatttc ctgtagtctg atatggatag 2356201 gagccttcta tatttctcca ataatccaaa gacatatgtt ccgctccttt ccctatccca 2356261 atatattttc ttcagactct tcaacataag atgaaataaa tcggttcaat ttatcagcaa 2356321 gaccgcccgc cccaaatctt atatacttgc tggaaacttt cggattatct tctttcaaaa 2356381 agcttaaaaa agataaaata taaatgcgcc tgtaagctac ttgtgtaatt ccgtactcaa 2356441 aaaaccagtt atcaatgaca ttgtatacgc ctcggttgac gccatatagg ttattacatt 2356501 tcttgtaaaa gcagagatcc ggaagattta actcctgatg ggaaagaagg ctttcttttt 2356561 tgtttggtgc cataatccca atcagctcaa agcgttttgc aacgcacgaa atatcctttt 2356621 taatttgctt tgttaaagac tccaaagaat caaaccttct ttcttctcta attttaaaga 2356681 gaatgctgca ttcgattttt tctccataaa tgtctctatg aaagtcaaac aaaaaaatct 2356741 ccaatgtctt ttcaaggtta gagcccaccg tcggtttcac accgatattc ataaccccta 2356801 aatgaaattg atgattgact gtcgccagaa ccccataaac tccattacgc agcccatgta 2356861 tttttgcatc tacatttgcc gtggggaatc caagctttct gcctaattgt tttcctttca 2356921 caaccgtacc ggcaatgatc gtcaaaaaag tcagcctcct ctctcagctt ccgcattcga 2356981 tcagacgaaa cctaatgatg tgatgaatgt aaaacggatt gatgctgcgg aatgccaaga 2357041 ccgagatttt cccgcaatgt cccgccgcga taatcttgac gataaagccc tctttcttga 2357101 agaatcggaa tcaccttttc tacaaaagca tcaagtgttc ccggtatatc cgacccaacg 2357161 ataaacccat ccgccgcctc agcgttgaac caagtttcaa ttaaggatgc gacacgctct 2357221 ggtgttccga tgaatagagt ccgtggaaaa gccatttcct gtgctacctc ccgcaatgtc 2357281 agatttctgg cttttgcttc tctcttaatc cggtctgttg tgctttgaaa cgcattcttt 2357341 cccacatcgc caatatcggg aaatggctca tccaacgggt aaacactcag atcataatca 2357401 tcaaaaaaac gggccaaata agtaacagca ttttcaatcg gtatcaattc tgcaaattca 2357461 cgatacttct tttccgcctc ttcttccgta tctgccacaa tcgggctgat ccctggaaaa 2357521 atccgcacac ttgaaggatc acgcccttca tcagcagctc ggcttttcac atccgcataa 2357581 aacgcttttg tctcttctaa tgaattggaa tgggtaaaaa tcgcatccgc atttttagca 2357641 gcaaactgcc ggcctgtttc tgatgaaccc gcttgaaaca ctacaggctc tccctgctta 2357701 gagcgcccga tattcaaggg cccctctact tgaaaatact ttcctttatg attcaggcga 2357761 tgaagcttcg cctgatcgaa aaactgccct gttttcttat tgtgtataaa tgcgtcatgc 2357821 tcccaggaat tccacagccc gcgcacaaca tccaaatgct cttgtgcgat ctcgtaacgt 2357881 tcagtgtgtt ctggcaaatt agacttacta tggttgcgcg ccgctccttc ctgcggcgaa 2357941 gtaaccagat tccagccggc cctgcccccg ctgatatggt ccagcgacat caattgtctg 2358001 gagatagtga atggctcagt aaaagatgta gagaacgtcc ctactaaacc aatatttttg 2358061 gtaaccgatg ccagcgcaga taaaatggtg atcggttcaa aacggtttaa aaaatgagga 2358121 atcgattttt cagaaataaa taagccgtct gcaatgaaaa taaaactaaa caaacctttt 2358181 tcagctgttt gcgccttttt catgtaaaat tcaatattcg tgctggccga gggatcaaca 2358241 tcgggatgac gccagccgtc agttgttccc ccgacaccgt gaatcatggc tccaaactga 2358301 ataaaatctg cacgtgtcat ctttttgcct cctttatctg tgcatgatta gcaagtgcaa 2358361 gatcaaggtg ttcaatgccg atttcagtta tcccttgata ctgattgccg cgcccgattt 2358421 cgaccacagg cacatggcgc accccatatt tcacctgtaa aatatcccga agcttttctt 2358481 tctctgaaac atcgatattt tggaacggga accctttttc attcaaataa ttcttgactt 2358541 cctcacaata cgaacagcct tttttactcc aaaccacaat gttcacaaca tcactcattc 2358601 ttctgtccct ccttaacgtt ttgcagctaa aactgcatcg ctcagcagct gataagacag 2358661 ctgtttttct acagcatttt tgatcggtgt aaaaataaca aaatcattga ttttgtatgt 2358721 gcctgataaa cgtgttaatt cttctgccac ttcttccttt gttccggcaa taatcccggt 2358781 tttttgcacg atgatgtcat agggctctgt gacgttttcc agataggcct cagcctgttc 2358841 gcgggaaccg acgttgacct tacgcccgtc tttcaaaacc acttttatcg attcacgcga 2358901 cacaatatgt ttttccgctt cttcttttgt atgtgccgca aaaacagcgg gggcaagatg 2358961 aaattcagcc tcagatcctg gcgggagatg cgcgtcaaat gctcggcggg cttccttcag 2359021 cacttcctct tcaccgttaa taaagtaagc aaagacaaaa gagattccca gttttgcagc 2359081 agaaatggca ctctctgtgc ttcctcccaa tagaaaaata cccggcttcc gatcaacctg 2359141 cggcctagga cgcaatgcgg catagcggtg ggtatcagga aaatcatccc gaacgaaatg 2359201 agtaagctcc tccagttttt catcaaactg acgcaccggt tttttatatt cggcctgcag 2359261 cgcgtctgtg gacagctgaa acccgccggg cgctttgccc actccaagat ctatacggcc 2359321 gggagctaac gctgatagaa gatggaattg ctccgctact ttataagagc tgtaatgctg 2359381 cagcatcact ccgcctgatg ctaaacgaat ttttcttgtg cttgcagcaa gatagcctaa 2359441 aagaacctcg ggtgcagacc ctgcaatctc atcattgttg tgatgttcgg ccacccaaaa 2359501 tcggtgatat ccacattctt cagccatttg tgccaatttc actgtatgct gtaatgtatc 2359561 agctgctgtc tccccttcac caatcaagct ttggtctaaa atacttaagc ggatcatatc 2359621 accggctcct ttatgtgttc ttttggttca aataaatatt ccggcgaaac acggcggaga 2359681 aactgcctcg ttctgtcttt tttggtatgg cggaagactt cctccggggt tccttgttca 2359741 acaatgactc cttcatccat aaaaacaact tgatcagaga cccttcttgc aaactccatt 2359801 tcatgtgtaa caacaatcat ggtggctccg gttttcacga tttccagcat tacctcaagc 2359861 acttcaccga ccagctccgg gtcaagcgct gccgtcggct catcgaacag cagcacatca 2359921 ggatgaatgg caagcgccct tgctatccct accctctgct tttgtcctcc cgataactga 2359981 ctcggataag cgttcaattt atcttgaagc ccgacctttc tcagttcatt ttccgctacg 2360041 gcatacgcgt cttgttttct cattttccgg gcaatcgtca agccctccat gacattttca 2360101 atcaccgttt tgtgagcaaa caggtggtat tgctgaaata ccattgccgt ctgttttctg 2360161 agccagtgaa cctctttttt ggacggaaag cggcaattaa tcactttgtc atgtatagaa 2360221 atgatccctt cgtctggacg ttctaataaa ttcaggcacc gtaaaaaggt ggttttccct 2360281 gatccgctcg gcccgataat cgtcacaact tctcccttgc gtaccgtgag atttatccct 2360341 tttaatacat ggtggatgcc aaactgttta tggatatttt taatctcaat cataaagtgc 2360401 ctccttgaaa tctggctgcc tttctctcta atactccatt tgcggattct aggattagag 2360461 tcagcaccca atagataatc gctgctccga taaacgcttc taaaaatgca taattatcag 2360521 aagcaacgat agtcgccgtc cctgtaatct ctgggacagc cactatagcc gcgatagagg 2360581 tggtatgcaa aaagccgata cccaaatttg tgaagtttgg gatggaaacc ttcagcgcct 2360641 gcggcaatat tacacgccga aaggtttggc tgtatgtcaa gccgattgaa taagccgctt 2360701 cgacctgtcc ggtatccatc gccagaatgc ccgaccggat gatttctgtg agataagctc 2360761 cggcagttaa agacaaggcc atgatgacaa acatggagac cggtatctca ttagcggacc 2360821 agccgagatg aaaaaaactg ctgacttgat ctgcaacagg cggtatccct aaataaatca 2360881 acataatgtg aagaattgca ggtgtacttc gaaagaaaga cacataaaac cttgagcaag 2360941 ccaccaagcc cttaattcta aaaattctaa caattatatt tccaagagcc acgagaaatc 2361001 caaacacaat cggcaaaaca gccatcatca atgtcagagg aatggtcttt accatttctt 2361061 tcatggcgga aacgataaat ggaaagtcaa attgcaatct tctcccccct catccgaaga 2361121 aatatatcaa tgtatgttca tgtcaaaaac agtaacaatc cttgtttgat tcttcttgat 2361181 tcgtttttct gccactcgaa agaaccattc gaataaaacc gctacagcat aataaacaat 2361241 cgatagcgca atgtaaactt caagagaatg gttgcttgag gtaatcagtg tttggcccct 2361301 tccggacata tccataacac ctattgaaaa ggctagagac gtatctttta aagaactgat 2361361 caccatgttt cccatattcg gaaacgcctg gacaagtgcc tggggcagaa cgattcgcct 2361421 gaaggcctga ctaccgctta agccaatact gtacgccgct tccgtttggc ctttatctac 2361481 actgcccacc cccgctcgaa tgatttctgc ggctgccgct gcattgctta acgcgtaggt 2361541 tgcgacagca gcataaaacg ggtccatttt tgatgtatca atcccgataa gccccgtaag 2361601 cgccgggatc ccgtaaaaca cgatgaaaag ctgcaccatg ataggcgttc ccctgaaaaa 2361661 cgagatatac acttttgcca attgatttac aattggaata ttatagatgc ggggcagtgc 2361721 cagaaagagt cctaatacaa aaccgaaaag caaggacagt gttaaaatgt ataatgtaac 2361781 cggtaaataa gcggttaacg tcggcacaaa atctccaatc atgttcatat caaacgcttt 2361841 ttccatcact gctccctctc tttttaccta atactgctct ttggaatagt cgtcaccaag 2361901 ccatttcaaa ctgagccttt tcaacgttcc gtcatcaatg atttcctgta aggctttatc 2361961 aatatcgtca cttaacgttt gttcattttt gttaaacata aaatacactt tggcatttga 2362021 aagcacatta ccgacggttt tttctttaat agtgctcgtc ttgttttgaa agtctactgc 2362081 aaaaggcgtt gagatcgttg cgtccgcacg ccccgatttc agctgattcg cagtctcatt 2362141 tgcgccttgg ccctcatagg caatctcaaa cggccgtcca ttatcctcat tccatttttt 2362201 cagtacaagc gctccgttgg aggttgcact cgtaatcacc cgttttcctt ttaagtcttc 2362261 aattccacgg atcgtatcgt tattttgaag cacagtaatt tttaaaggaa aatggttgta 2362321 agcaaccttg ttaaacagaa attttttctc acgctctttg cttttctcca tttgatgtgc 2362381 cacgatatcg actttatgct gtccgaggct gacaagcagg ttggaaaatt ccatcgtttt 2362441 aaatgtgaat ttataatgtg gcaggcgctt atcaagctct ttgatcagtt cgacatcata 2362501 accggttaaa tcgccttttt catcgataaa gcaaatattc ggaaattggg ttccagttcc 2362561 gaccgtgatc gtctgtacct tcttttgccc ggctcccgtc gtttgactgc ctgcaccgca 2362621 agctgacaga actgttataa gcgaaaataa tattgccatg aatgctgttt tcgttttcat 2362681 ctcatcgccc catttatttt tcaaaacttg attttgaata atctgccccg agccattttc 2362741 ggcttagttt ttttagcgtt ccgtttttct ccagcttttt aatcgcttga tccgtgtcat 2362801 ccgccaaggt ttggctgcct ttattaaaca taaagtacac ctcggtatct aataacacgt 2362861 caccgactgt cttttggcgg aaggcgtgcg ttttattctg aaaatcgacg gcaaacggtg 2362921 tagctatcgt tgcatctgcg cgcccggttt caatttgatt ggcggtatca ttgcttccct 2362981 gtcccgcata tttcaaatga attgggctgc cgtgcgtttt gttgtacttt gtaatataat 2363041 ctgccgcatt tgacgtggcg ccaactatga ctgtttttcc gtgtaagtct tttaatgtat 2363101 gaatcttgtg attatcctct ttcaccgtga tgtacatcgg cgagtagtta tatgggactt 2363161 tatgatacaa aaaacgcttt tctcgttctt tatttttggc catattgtgc gcaatcacat 2363221 caattttttt atttccgaga ctcgtcagca aatttgagaa atccatcgtt ttaaattcaa 2363281 atgtatattg aggcaactcc ttatcgatgg ctttcatcac ttcaatgtca tacccggtca 2363341 attcaccttt ttcatttaaa aacgcaatat tcggaaaatc tgttccagtg ccgactatga 2363401 ccgtttgagc ctgacgatct gttttgttat ttgtttgcga acatcccccg ccaagtaatg 2363461 caaacactga cagcagcaaa accaatcctt tacgcttatt cataggctgc ctcacatcat 2363521 gcccagctgg gcgcacctaa aagcgttggg ttaaatcgtt ccggaatcag aaccttgtgc 2363581 atcatcacac ctatgtcccc gtctttttcc tgctcaaaat acacttcata ccctctcctt 2363641 ctgtacatgt cagcaagcca aggatgcttg cgcgccgatg tgccgagtgt cagcgcagga 2363701 gccttcagca tatctcgaag cactttttct tcaacatacg taagcagctt acttccggcg 2363761 ccttgccctt tatattccgg cagtgtcgca aaccaccaca caaatggata ttttgaagga 2363821 ggcgtctcac tctcccacgg gaacctgatt gtaatcgttg aaatcagctt cccatcccgc 2363881 tccagcacaa tcgctgaatg atgttcaata ttttctgata ccatttggat atcagctctc 2363941 gtggatggcc aatcaatatc cagctgccga atgggctgaa atgcgctgtt aaccagtttc 2364001 aacagctccg atgcatcttc aacagttgcc agtcgaaaaa tatcatcact catttttgtc 2364061 actcctcttc acaaaatata taattcctat ttgtttacta agcttttatt gtttatacta 2364121 taaagcatac tctgatcttt gactaatcaa aaaaagtaaa ccttcacttc agtaatttta 2364181 atgatgaaaa acaggaggga gcacattgga gttacgctca atcaaaacgt ttcatacgat 2364241 tgtaaaattt ggaagcttct ataaagctgc agaaatactc aactactcgc agccgacgat 2364301 atcgatgcgt atgaagcaat tggagcagga tttaggcgta ctgctgtttg aaagaggaaa 2364361 aagcctgcag ttgacaaaag cagggaagct tttttatgaa cgaacaggag atcttttgat 2364421 gcaatacgag gcgcttaaac acaacctctc cgacttaaag gaagaagagg caggcattat 2364481 caacataggg gtttcagagc caaccgccag tctgatattc cccgagattt taaaggattt 2364541 cttaatggat tacccaaaga taacggttaa tatcaaggtt gatgacgcca atacctgcag 2364601 tcaaaagctc ttagacggga cgattgattt tgcagtctgc ggcgagccgg agctgattct 2364661 tgaaaattac taccatccat ttttttatga cacattaaat gtgattgtat ctgatcaaca 2364721 tccgctcgct gagaagaagg ctgtccattt gtctgattta gcagaagagc gcttcatatt 2364781 tacgcccgcc aattgcccca ttcgcttaca aattgaacag catttacata gagaactcgg 2364841 gaatcgctac aaaaaaatgg agctcacaag cagcatgtca catgaatatt acgtacgtga 2364901 aaacatcgga atttcaatct ttaccagcac cgcacattct aaaccgttca acggcactaa 2364961 agtcattcca attctgaacc tggatatcac cccgcccata gggctgttga caaatcaaaa 2365021 agaagttcat tttgaccgcg ccacgaagga cttgatcgcc cggataacca aacgttttca 2365081 gcagcgcagc aaagaattgg aaggaacctc tgataagacc attacaggat aactgaaaaa 2365141 ataaaaacca cctcctgatt catcaggaga tggtttcacg gtttaaagct cgatcgtctc 2365201 accgaccgac atgactttgc cgactccgcc cggcaggctg tcagcgaatg cttctgggtc 2365261 ttgttcgatg accgggaatg tattgtaatg caccggcacg acctgttttg cgcgcagcca 2365321 ttcagcagca agcttggcgt cttcaggccc cattgtaaag ttatcgccaa tcggaaggaa 2365381 agcaaggtcg atatgattca attcgccaat gagtttcata tcagagaaaa gtgccgtatc 2365441 gcccgcgtgg aaaatcgttt tatcttctac agtcagcaaa ataccggcag gcatgcctgt 2365501 gtaagtgatc gttttgtttt cttcatctgt gatggctgat ccatgaaagg cctgtgtgag 2365561 cttcactttt ccaaaatcga actggcggga gccgccaata tgcattggat gaacattcaa 2365621 gcctttccag cctaagtaca cagcgagctc gttcggggct ataaccagcg cgttattttg 2365681 cttggcgatt tgttcagtat caccgacatg gtcattgtgg ccgtgcgtta gtaagatgac 2365741 atccgctttt acatcctccg gctttatatc cgttaatgaa ttccctgtta aaaacggatc 2365801 aaaaataata tgatggtcct tcgtttccac tgtgattaca gaatgtccgt gatatgtcac 2365861 tttcatttct ttcacctcgt cacatgattt tgtttttttt attttccctt tttaaaaagc 2365921 tgaaaaactt atgttgtttg attcttgtta atgacattga ggcctccggt ggcttcaatg 2365981 acagtccctg tcacaaggtc tgagttctcc tcacacaaga aagcgataat cctggcaata 2366041 tcctcgcctg taccggatct tcctatcggc gttttttctt tgccgattcg cattctggct 2366101 tcctctatcg atgcttcttt catgtcgccg acaatgtctc ctgggcaaac catgttggcg 2366161 gttatgccga attcggcttc ttcaatggca attgtcttcg tcaaagaagc caagcccact 2366221 ttcgcagcgc caaatgccga tcggtgaagc cagccgggcg cgtgagccgc accttggaat 2366281 ccgtacgtaa taatgcgtcc aaattgctgt tttctcataa taggaataac cgctttgaat 2366341 aaatgaaaga cggcgcttaa atttccttcc agcatgccat accattcatc atcagtataa 2366401 tcggctaact ttttacgttc aaatatgtat ggtccagcgt tgttaatcaa aaagtcgatc 2366461 cttccgaagc ggtttaaggc agcctctgca atacgcagca gatcttcttt tttggtgaca 2366521 tcacctttta caaattgcag ccggtcaaga caatcgggac aggcttcctt caggcggctg 2366581 actgcctcct catcctgtct gtaattgact gttactgaat acccctttgc aagcaacgtt 2366641 tcagtcactt tgcggcctaa acccttcgaa ccggcagtaa ttaaagcatg tcgcacatga 2366701 atacctccca aagcaacgtc gccgctttca ataaagtgtt tcttcttcta ctttactata 2366761 aaaggcttgc aatatcactt tttacacttt ggcatacaaa aaaagctgcc tgtacagaca 2366821 gcttattctg caggagatga agactcctga tcaggcatat cgacataacc gctttgatat 2366881 gcttctgaaa tgagccttgt tgtctcctgg ctttcttgtt catcataaat atagcgttcc 2366941 ggttcttttt tcatcattct gcctcccatc attatagagg taggttggct ataatgacgg 2367001 gattttatga aggaaatttt aacaaactcc tgctgccacg caagctttcg ctttttcaag 2367061 cgcctgttcc acctgtttga atccggtgcc cccggcgctc attctttttt caactgcgta 2367121 gtaagggtct aacacagtgt aaatatcttc ttcaaatagt gtgctcgcct gctgaaactc 2367181 gccaaacggc atatcgctta aatagatccc tctttcgatg catgtgtaca caagtttccc 2367241 gaccacttca tgcgcttctc tgaacggcat tcctttttta gctaaataat cggccagttc 2367301 cgtcgcgttt gaaaagtctt gttttgttgc ttgcttcatg acgtctttgt ttacagtcat 2367361 tgtttggatc atgcctgtga agatttgcag gctgccctcc accgttttca ccgtgtcaaa 2367421 catgccctct ttgtcttcct gcagatcttt gttgtaagcg agcggaagtc ctttcatgat 2367481 cgtaaacagc cccatcatat cgccgtatac gcgtcctgtt ttgccgcgga tcagctccgc 2367541 catatcaggg tttttctttt gcggcatcat gctgcttcct gttgcgtacg tatcgtcaag 2367601 ctcgatgaat ttaaactcct gcgagcacca taaaatgatt tcttcagaga aacgggatag 2367661 gtgcatcatc agcatactgc tgttgcttaa aaactccaaa atgaagtctc tgtcgctgac 2367721 gccgtccaag ctgttttcat aaatggcatc aaagccgagc agttccgctg aataatcacg 2367781 gtcaattggg aaggttgttc ccgcgagcgc cccgcagccg agcggagatt tgttaatccg 2367841 cttcattgaa tcctgaaaac gctccttgtc gcgctcaagc atccagaaat acgcaagcag 2367901 atggtgagcg aatgaaatcg gctgggcgcg ctgcaaatgt gtgtagcccg gcagaatcgt 2367961 ttcaacgttc gcttccgcct tttcaatcag cgcactttgg aatgcctcaa tcagctcgat 2368021 gatgtggccg acatgattct tcaagtataa atgcatgtca gtcgccacct ggtcattccg 2368081 gcttctgccg gtatgcagct tgccgccaag aggaccgatt tcgtcaatga gcattttctc 2368141 aatgttcaaa tgaatatcct cataatcgac tgagaattcc aatgctccct cctctgcttt 2368201 ttgcaaaagg gtattcaggc cctctcggat tttcaactct tcttctgctg tcagaatacc 2368261 gcattttttc agcatggcag catgtgcgag agaccctgta atgtcttcag caactaaatt 2368321 ttggtcaaat gatatggacg cgccgaactc gtcgacccat ttttccggtg ttttttgaaa 2368381 tcggcctccc caaagcttct tcatgcttta atctgctcct tctttttcac gatgctgttc 2368441 acttttgtcg gaagtcccca aagctcgata aatccgattg ctgcatggtg atcaaatgca 2368501 tcgtcttttg tatatgttgc aagtttttca tcatatagag agtattccga tttacgtcct 2368561 tctacaattg catggccttt aaacagcttc acgcggacaa tgcctgtgac atgcttttgc 2368621 gtttctttta agaaagcgtg cagcgcgtct tttaacggtg agaaccataa gccgttgtaa 2368681 atgatttctg acattttttg ctcgatgatc ggtttaaagt gggctacctc tttcaccagt 2368741 gtcaaatctt ctaattcttt atgcgctttg atcagtgtca tcgcaccagg gcattcgtat 2368801 acttcccggg atttaatgcc gacgaggcgg ttttccacgt ggtcgatacg tccgacaccg 2368861 tgcgcgcccg ccatttcatt cagcttcaag atcagctcag aaagcgagta ggaaacaccg 2368921 tcaatggaga caggcacgcc ctgttcaaat gcaatttcaa tcacttccgg cgtgtccggc 2368981 gttttttcca gcggagctgt taaatcgtat gcaccttctg gcggcgccgc ccatggatct 2369041 tctaaaatgc cgcactcatt ggcgcgtccc cagaggtttt ggtcgataga atacgggctg 2369101 tcaagattga tcggaatcgg aatgccgcgg ctagccgcat attcaatttc ttcttcacgt 2369161 gaccactgcc attcgcgaac cggcgcgatg acttctaggt cagggtttaa tgatttaatg 2369221 gagacttcga aacgaacctg gtcatttcct ttccctgtgc atccgtgggc aatcgcctgt 2369281 gcatcttctt tttccgcaat ttcaaccagt tttttcgcga tcagcggtcg agataatgcc 2369341 gaaacaagcg ggtattttcc ttcatacatt gtgtgggcct gcaaagagat aagcgcgtaa 2369401 tcctgtgcaa attcttcttt tgcatcgatc acgtaggagt ttgtcgcgcc gacttcaagc 2369461 gctttctgct gaacaaatgc caaatctttg ccctcaccga catccaggca gcaggcgatt 2369521 acattatatc cttgctcctg aagccatttt attgcgacgg aagtatcaag acctcctgag 2369581 tatgctaata cgactttttt ctgttctgac atgataaaaa tcccctctca accgtgtttc 2369641 tattttgtat aaaaataaat tatatttaat aaaaatacat tttgtatgta tacactttaa 2369701 caagtacgtt tcgttttttc aagcctttta taaaaaaaac ttcacctaaa tttcaggtga 2369761 agtttcatag tatttattca tttacttgtc ttttctgatt tctctgacca catgcgcaag 2369821 ttcgggaata atcagcttat tcattgccag ctttactgcg ccgcttgagc ctggcgttga 2369881 gaaaacagcg gtatgctgaa tgacgccggc agttgctctc gacatgattg cggcagagcc 2369941 gatatcctct gtataactca gcatcctgaa tatttctcca aagccgggca gttctttcga 2370001 aaacagcggc gttatggctt caattgtgac atcccgatct gctatgcctg tccctccgtt 2370061 taagagtacc gcgtctgtct gttcatccat gcagcccgca agcactgacc gttgcaaagc 2370121 atccttttcg tcttttacaa tttcatatgc ggcaatatga tgaccggctt cttctaaaaa 2370181 tgagatcatc agcttgccgc ttttatcggt ttcatctgtc ctcgtgtcac tgacagtaat 2370241 cactttgcac cgaacgatat cgggagcttc ttgtttatgc tcttgaacgc tcattggccc 2370301 acctctttta tgttttctgt ctgtcactat catgcatcaa caaaaaagca cattcaagag 2370361 aatgtgcttt catgcgattt attttgctaa acgaacaacg tcgcgcgcaa tcatgacttc 2370421 ttcatcagtc gggatgatca tgacttttac tggagaatgc ggatagctga tgaaagcttc 2370481 ctcgccgcgc acgttattaa gcgcagggtc ccagtatacg cccatgaatt ctaaaccgcg 2370541 aagaacgcgt tctctgactt ccacactgtt ttcaccgata ccggcagtaa agatgatcgc 2370601 atctacaccg ctcattcttg cagcgtaaga accgatgtat ttgtggattc tgcttgcgaa 2370661 tacttcaaga gccgtttccg cgcgctcatt tccttctttc gtagcttcaa cgatgtcacg 2370721 aagatcgctt gagaaaccgg aaatgccgag cagtccgctt tttttgttta atgtattcag 2370781 tacttcgtca gccgtttggc ctgttttctc catgatgtat gggatcaggg cagggtcgat 2370841 gtttccagag cgtgtgccca ttgctacacc ggcaagcggc gtaaagccca tggatgtgtc 2370901 aatagatttt ccgccttcaa cagcggcaat acttgctccg tttccaaggt ggcaggaaat 2370961 caggcgcaag tcttttaacg gacggccgag aagctctgcc gcacgctcag ttacatattt 2371021 atgtgaagtg ccgtggaagc cgtatttacg gatgccgaat ttttcatagt attcatacgg 2371081 caagctgtaa aggtaagact gctcaggcat tgtttggtgg aatgctgtat caaatacagc 2371141 taccgcagga acatttggaa gcacttcttt gaacgcttta attccaacga tatttgccgg 2371201 attgtgaagc ggtgccaatt cagaaatatc ttcgatttcc ttaatggttt catccgttaa 2371261 taaaacagaa tcgctgaatt tttctccgcc gtgaacgaca cgatggccaa ttccgtcaat 2371321 ttcattcaag tctttaataa tgccgaattc cgttaactta ttcagcagca ttttaacagc 2371381 taccgcatga tctggaatat cagttacttc tgtatttttt tcgccgttca cagaaattgt 2371441 gaatacgctg tcggcgatac cgattcgttc aactaaaccc ttcgttaaaa cggtttctga 2371501 aggcatttcg aaaagctgaa atttcaaaga cgagcttcct gcgttaattg caataatttt 2371561 ggacatgatt gacgctcctt tatactctgt atcaacaact tcgtttttcg tacttttttc 2371621 ccggtgaata tcaacatctt ctccgaaaaa tatctgactt ttccatttaa acattgtcat 2371681 gtcggctttt caagtcaact tgcgtattga taacgcttac aataagaagt cgttattttc 2371741 agacacattc actataggtt ttgtattgat gaacgcttac aatttgcggt ttttccctct 2371801 gtattttgtg tttcaaagct ggattcaatt cgtcaagtcc ggtcttcaaa agcataaata 2371861 aaagcagctt aggcatcgac ctcatacggc tgtctaagct gcttttaaaa cacttacttt 2371921 tcttttttaa accattcatc aaattgagcc atcatatcaa gcatcgcctt ttgattggag 2371981 aaagacggaa gattcgcaag cagaatttgc cccggcgctt tcgtattctc tccttgtttc 2372041 tgaagcacaa ggatgctttt ggcatgagct tcgtctttaa aaatagattt tggcagctgc 2372101 aacagtgcgt tgatatgaac cttatctttg aaaaactgtt tcagcttgcc gctttgggag 2372161 ctctcaaaca aatgattcgg aatcataaaa aataagtagc cgcccggttt ggtatgcttg 2372221 acgctctgtt caataaacag atgatgagcg aaggaatggc cttcgtcagc tttgagctca 2372281 aacgcttctg ctccttcgtc attcggataa tagccgactg gcagatcaca aatgaccgtg 2372341 tcaactggat cgataaacaa cggctcaagg ctgtcctggt ggaaaagctc aagctctttt 2372401 ttcagaaggt tcgcttgggc ataggcgatc ttcaagagca catcatcaat ttcaatgcca 2372461 aagctgtttg ccgttttttc agacagctgg ttcagcacgg taaacagaag gttcccagtt 2372521 cccagggctg gatcaagaat ggtcagttcc tttttgtccg ccataaattt attcaccaaa 2372581 tagctgatga aaagcccgat cgtatccggc gtcatttgtc tgtttggatg cgagatatct 2372641 ttcattcctt taaggacggc aagctgaaaa gccttgcgta cccactcatg ctcatacgtg 2372701 ccgaattccg ctttttcaag cagagcctga agttgtttgg ttttctgatc agcaggcagt 2372761 ttcagctgat ccgttttttc aagaaaatac atttctcctg cttcggccag cgcctctata 2372821 tatgaaatct gcaattcatt ctttatcata atcgcggctt cgtttaacag ctcatacacc 2372881 gcacctacat ggtctttttg catattgtgt tcctccttgc catgaaaaaa gctccggcgg 2372941 cagcctggag cttttttccc tgcttacttt actaatgcct tagcagcctc aattggcttt 2373001 tcatagttcg ggtggtttgt tgcttcgctt acatattcag cgtaaacgac ttttccgttc 2373061 tcatcaagga caaatacgga acgcgcaagc agacgaagtt ctttaatata cacaccgaac 2373121 gcttcgccaa atgacatatc tctgtggtca gacagtgttt ccactttgtc aattccgtta 2373181 gcgccgcacc agcgcgcttg cgcgaatgga aggtctgcac tgattgtgta gacgttgaca 2373241 tctccaagct ttgcagcttc ttcgttaaaa cggcgtgttt gtgcatcaca aacacctgta 2373301 tcaattgaag ggataacaga aataatcgtt acctttcctt tcatgtcagc taacgatttt 2373361 tcttcaaggc tgttagtcag cactgtgaaa tcaggagctt gatctcctac cttcacttct 2373421 tgtccgacaa gtgtaaccgg accgcctttg aatgtaattt cagccattat aattcctccc 2373481 ttttgtatgt atgtctctat catagtaaag tttcctgcaa actgcaaagt ttatgccaaa 2373541 aaaaagttaa ctgcggccag cgcagttaac ctttttttaa taattcatat tgttcatttg 2373601 gttttgattt tggccttggc tttggttttt gttatttttc ttgaacattt gctggatgcg 2373661 ctcgagtgtt tgaggggctg cgtctaaaat tttctctatt aaatgggtat tttcatctaa 2373721 atgaagcatt ctgatgcctg tcgatccgac aattaaaaac gcgatcggcg taatggacac 2373781 accgcccccg cttccgcctc cgaaaggaag tttctgttct cttgtctcat cgtcttccga 2373841 tttcttttcg gccggctttc cgccaaactc gcttccgcct gcggcgaatc cgaatccaac 2373901 tttagaaaca gttaaaatca cacttccatc aggcgtttcc actggatctc cgatgatggt 2373961 gttaacatca atcatttcct tcaagttttc cattgcggtt ttcattaaac cttggatggg 2374021 atggtctgcc atatacgctt cctccttaaa ctgatgaatc attctttgaa gtcattctag 2374081 ccgacggatt cttctttaat acggatagct cccgtccgta tttgacgaat ttgaaagctg 2374141 caagcatagc atgtccaaag cgaaaaaaga atatacactg aaaatgggtc ttggaaacag 2374201 ggacttgaaa cgacgggatc acctcataga caggtttatt cacaaagtcc aggtggtcgt 2374261 agagcattgc tgcgataccg cccttcacgc cccatacagc accggttaac acacctgtca 2374321 ctgccgcgtc ctgaattccg attactgtaa cccattctag ttttgtgata tgtaaatgcg 2374381 cgagaaaaga cgcgctgatt ttccgcagtc tggtgacctg atgcaaaagc atttcgattt 2374441 tattaatgct ttgctgcaca tcgttttgtg taattttttt ctttccgctg ctttttttca 2374501 ttttggattc agttttttgt ttgatatcca ctgttccgtc ttctttgttc accttaatcg 2374561 ccgggattgt ttttttgatc cttataaggc caaacagcgc cgtaatcttc aaggtcaatt 2374621 tgtcattatc atcggcatga agatactcca gcgcgacatg gattttcatt ctgagaagca 2374681 gtacgatccc tatgagaata agaatggctg tcagtacata caccatattc ttcacttcct 2374741 ctaggagcat tatcgccaat tcctaaaaaa ataaacccgg acggaagtcc gggttatcgg 2374801 ttatttgcgg tataattttt catgcaccac ggtggtatcc gcgatgtaat catgaatccc 2374861 ttgttttgta ggtgaaaagg caacaacgat atataaaatc caaatcttat caatataccg 2374921 tccaaccact tcacgaaaaa tcactgtact ccatgtcagc ttgctatctt gcttcacaga 2374981 aaccactttg aggccgaaca ccattttacc aagcgtctgc ctgaagtatt ttgtcatgag 2375041 tgcgaaatag gcaagataca caataagcgt tgtcacactg taggccgaga aggtaaacat 2375101 gccggatgtt ttcggcagat ccaatacggt aaagagggga gaaacgagca aatggtttaa 2375161 tccccatatc acgagccaat caagcaggaa agcccagaaa cgaacccaaa agccagcata 2375221 ggcatgtgtc agcagctccg cttcttgcgg gcctttgatg tcattgcgct ctaactcttc 2375281 atatgtcgcg tccattattg ttccctccta cttcgcatag agatacatca ttctcggcga 2375341 accggattgc gatagaattt ctctcatatt caaaaaatca atttcacttt taaacatttt 2375401 gttcgcgccc atggaaaaca gtgagcctaa tccgaagctt tcctcataag aaatgacaga 2375461 ggcgtttttc aaatccttgt gatccttttt catggccgta atggtatcgt cataaaaacc 2375521 aagctcatca acgaggttca gttttttcgc ctgccgtccg tcatacacgc ggccgtccgc 2375581 aattttcttt acctctgctt tcggcatgcc gcgccctttt gaaatgacat caacaaagcc 2375641 ttcatacgaa ttatcaacca tcgattgcat gatgtttttt tcttctttcg tcatctcacg 2375701 ggaaggagac ataatgtcct tatgggcccc gctcttaatc gtttcaaaag aaatgccaag 2375761 cttgtcggca agctttgaat aattgacgct ttccataatg acgccgagtg acccggtcag 2375821 ggtttccggt gtcgcaaaaa tcttatcagc cgctgttgag atgtaatagc ctcctgatgc 2375881 tgccatcgaa cccattgaca cgtaaatcgg ttttttcgtt tctttcttga tttcttccag 2375941 tttcttatgt atttcagcac tttcatacac tccgccaccc ggagaattca ccttcagaac 2376001 gatacctttg accgtcttgt catcttttgc gcgctcaagg ttttttaaga acgttctgtg 2376061 gttatatccg tctgcaccaa gcagactgct tgagtcccca ttatcctgaa tggtgccgct 2376121 gacctctaat acggcaattt tacttgaggg actgccgttt tccagcgtct tctcctgcga 2376181 ttcatccgtc agtgatgtga gatccgtttg agcgcctttg acgctttcaa agaaactcat 2376241 agagatgctg acgataatag acacgccgaa aatccccaga gcaatcacta atgcaatcca 2376301 tctttttgca ttcatttttt ctcctccttt ttcctaaact ctctcattat acgattcaat 2376361 atgaaaaatg tttcacttca tgagaaagct ccggcttaac gggctgccgg caaacgtggt 2376421 acacttatgg ccaaaggtat tttatcacaa atactggatg gcagaaaaac ttaaatatga 2376481 cagcaaaggg gaaatgggat atgaccgatc aacgccgtaa tgtttatttt tttcacaaac 2376541 aggatcagga aacgaacgaa caagcccgct cgttaacaca attagcggaa gagcatggat 2376601 ttaccgttgt gaaccagcac tcagacgcca atattatcgc tagcattggc ggggacggca 2376661 catttttgca ggcagtcaga aagacgaatt ttcgtgacga ctgcttgtac gtcggcatta 2376721 ccaaaaaggg gaaagctcat ttatattgcg actttcatag tgatgagcga gaaaaaatgg 2376781 tcgatgcaat gacgtttgaa caaattgaag tgagaaaata cccgctgatt gaagtgacag 2376841 tggatcaagc cagtcctttt cactgcttaa acgaggtatc catccgctca agcatcatca 2376901 aaacctttgt gatggacgtg ctgattgacg atctgcactt tgaaacgttt agaggtgacg 2376961 gaatgattat ctcaacgcct acagggagca ccgcctataa caagtctgtt gcaggagctg 2377021 ttgttgatcc attgcttcca tgcatgcagg tatcagagct tgcatccctt aacaataata 2377081 cctaccggac actcggctcg ccatttgtcc tcagctctga ccgaaagctg acccttcgtg 2377141 tggtgcagga cggcaacgaa cacccaatca tcggcttgga caatgaagca ctcagcacga 2377201 gaaatgtgaa aacgatcgaa atcaaactgt ctaataagaa aatcaaaaca gtcaaactaa 2377261 aggacaattc attttgggaa aaagtgaagc gtactttttt atagaaaata aaaggacagg 2377321 ctgctgcctg tccttttatg atttctcata tacaatctgg ccgttaatca cggttttttt 2377381 aatctctaaa agatgaagct gtgcggggtc aatggcaaac ggatcaccac tgagaactgt 2377441 aaaatccgcg tcatagcctt ccgcaatttt tccgcgtgac ttctctttat aaatgatacc 2377501 ggcgctacct tctgtataaa gctttatcgc ttcatataca ggtaaacatt cactttcatt 2377561 atagcttggc ccgttttgct catgactgct tttccggagg accgcggact ggatccctag 2377621 aagcgggtca acaggctcaa tcggggcgtc tgaaccgccc gcgcataaaa tgcctttaga 2377681 tatgagggtt ttccaggcaa atgcagtctt catccggtct tttccgagac ggtcaatgac 2377741 ccacggaaag tcgcttgcaa cgaagtgcgg ctgaaggtca agtgcgatcg gcatgcgtgc 2377801 tgctctctcg attaattcgt tatcaagcac ttgagcatga ataagccgat catgccggcc 2377861 gtttttgggc ggatgctttt ctattgcgtt cagcactttt tcaaaagcaa gatcgccgat 2377921 tgcatgaaca gcaacctcca tccctttttc tctcgctttg cgaatgagcc ggccaagggt 2377981 ttcgtcatcg tgaacctgaa caccatttgt tgatggatca tcctgatatg gttctttcaa 2378041 taaagccgtt ctcccgccaa gcgccccgtc cgcaaagatt ttcatagcac cgaactccac 2378101 atacgggccg gacagcttct ccagctgctc ccatcgatcg acagcttcat gatgaacgag 2378161 caaatggcag cgaaacggat actttccgcc agcggcagct ttctcataag ctttcatcgg 2378221 caccgaaaca tcaccataat aggacaagtc ttccgaatga ccgcccgtca ggccttttgt 2378281 ccagcaatcc tttattgcag ccgttaatgc ctcatcaaca tagtgctggg agactggcgg 2378341 gacagccttc agaatcaaat cctgcgcctt atcaaacagg agtccggtcg gctcgccatt 2378401 tgcatctttt acgatgactc cgccgtcagg atcaggagta tttcttgaaa ttcccgctgc 2378461 ttgaagagcc gcagaattga cagctattgc atgccggcat atacgcttga gcaagacggg 2378521 cctgtcagga aacaggcgat caagatcatg cttagtcaag tagtcaggtg tctcaaactg 2378581 attttcattc cagccttctc caatgagcca atcgttttta ggaagctgcc gctctctttc 2378641 cttcgcagcc tgtaaaattg aatctttcga cgtcagtgcg gacagatcga gctgaagctg 2378701 tttctcaccg tggccgatca aatgtagatg gctgtcaaca aaaccgggga acatcactgc 2378761 tccgttcagg ctgatttctt ctgtttccgg cgacccgtac ttttccttca aacgttcata 2378821 gctgccggtg ccttttataa caccatcctc aacataaact gcctcagtcc gatcgccttc 2378881 ttcgagcatc gtataaatga aaccgccgtg ccatatcgcc ttcattcacg ttcactctct 2378941 ttctttacgc ctttttattg gctttgagct gttcttcacg ttttcttaat tccactcgtc 2379001 tgatttttgc agaagccgtt ttcggcaggc tttccacaaa ttcaatttct ctaggatatt 2379061 tgtatggagc ggtaatcgtc ttcacatggt tttgcagcat tttgacaagc tcatcactgc 2379121 gtttttcatg attttgcagg acaacatatg cctttacgat ggagcctctg atttcatcag 2379181 ggcttgcgac aacagcacat tcttttactt ctgggtgctt aacaagcgcg tcttccacct 2379241 cgaaaggccc gatcgtatag ccggagctga taataatatc gtcatttcgg ctttcaaacc 2379301 agaagtaacc ttcctcatct tttcttgctc tgtctcccgt taggaaataa tcgccgcgaa 2379361 tttgtgtttt cattctttcc ggatctttaa aatactcttt aaagagcgca ggcgtactga 2379421 ggtgaacagc gatatcgcca acctcaccag gtttgcagat ttcaccgtct tcatttatga 2379481 tctccacctg atttcccggt gtcggttttc ccatgcttcc cggtttaata ggcgtatctt 2379541 tcaaaacacc aaccaaaagc gtgctttctg tttggccata tccgtcccgt accttaatgc 2379601 caaagtgctt ttggaaaaca tcaatgactt cacggttgag cggctcacct gcggaaacag 2379661 cgctgtgcag ggcagaaaga tcaaagcgtt tcaagccttc aaccttcgcc attaagcggt 2379721 attctgtcgg agtgcagcag aaaacattga ttttgtagcg atttaaaagc tctagatatt 2379781 tttctgcttt gaatctgccg tggtacacaa aaccggttgc tccgctgcca agcaccgcta 2379841 aaaacggact ccatacccac ttttgccagc caggggcagc agttgcccag acgatatcct 2379901 tttcagaaat gtcaagccaa gcgccggcag aagtttttaa atgagcaaat gcccatccat 2379961 gtgtatgtac aacacctttc ggctgacctg ttgtcccgga tgtataagat aagaaagcca 2380021 tatcatctct tgttgtgtca gctgttttaa attggcttcc gtccgcttca attgataaga 2380081 ggtttttcca gccggcatca ttttcaccaa tagacagtgt aatcagtttg tcagccgtac 2380141 tgacatcccg gaaagcgcca ataaattcgg agtagacgat agcgcctttt acctctgcat 2380201 gttcaatccg gtattcaaga tctttcgcgc gaagcatttc ggagcacgga atgacaacca 2380261 ttcctgattt caggatagcc aaataaacag cataggcttc aagcacccgc ggaaccatta 2380321 caatcagctt gtctcccttt ttaaatccaa gatcagctaa ggccgctccg attttatttg 2380381 tttcttccat cagcttttca tacgaccaag attcttgctt gcccgactcg tcctcccaaa 2380441 gaagagcggt tttttgtcca gcagcactga acttttccat ttcattcact aaattatatt 2380501 gcacaggggc aattaaatct tcacgtttta acacgaacaa ctcctcactt tctccaccca 2380561 ttatacataa atacaggctc tttccgtaag gatatgccta aaagcaacct ctgtaaacat 2380621 agattttata ggccgctggt ccttttttat atgtaaaaaa tgaaaaagag tggggatacc 2380681 cccactccta agccattatg tgaaattgta aattagaatt gtcctccgcc catgttttgt 2380741 tgagcaaaag atacaagacg ttttgtgatc tctcctccaa cagaaccgtt agcgcgagaa 2380801 gttgtgtctg ctccaaggtt tacaccgaat tcagaagcga tttctaattt catttggtcg 2380861 atcgcttgag cagctcctgg tactaaaagg ttgttgctgt tacctgagtt attgttagcc 2380921 atgtgtctca cctccttgtg agtatagaat gtgtcaaaac acatggcttc attcagaaaa 2380981 actttggtaa ttgtatacag gagctgaaaa ttgatttaaa agagttcagc gaatttatcg 2381041 ttagcttctt gttcgctata aagggtcatt gtctcaatgt tatctaccgc ttcttgaata 2381101 tacggctcga aatcaacaaa gctttcaaag tgttcaattt tctctttttt agggcgtgtt 2381161 ttcgggcttg gcggtgtaaa gatcgtgcag cagtcttcaa acggctgaat acttgtctca 2381221 tatgtgccaa tttcccgtga tttttcgatg atttctgttt tgtccatggc gattagcgga 2381281 cgcaaaatcg gtgttgacgt caccgcatta attgcataca tgctttcaag cgtttggctc 2381341 gctacctgac cgaggctttc tcccgtaata atggcaagcc cgtttctctt ttctctgatt 2381401 ctgtcggcta tctgaagcat gaggcggcgg gttgccgtca ttgtgtaatt ttcaggaatt 2381461 tgtttttgga tgagctcttg cgtttttgta aatggaacaa tatgaagtgt catgcttccc 2381521 ccaaaacggg acagacattt cgccagatcc attacctttt gctttgcgcg ctcgcttgtg 2381581 tatggcgggc tgaagaaatg aacagcttct accgacaatc cccgtttcat cgcataaaaa 2381641 ccggccacag ggctgtcaaa accgccagaa agcatcagca tcgcttttcc tgctgaacca 2381701 actggcagcc cgcctgcacc tttttcatca cgaattgtca aaaatgttgc ttcttccctg 2381761 atttcgattc tgagcgggat gtctgggttg cgaacatcga ccgtcaatcc ttctgtattt 2381821 cgcaaaatat ggccgccgat ttcagcgttc atctggtttg tatctaattc aaattgctta 2381881 tacgctctct ttgtcgcgac tttaaacgta tcacctggtt tatactgatc tttgatagcc 2381941 tttagtgcgg ttgccttaat atcatcaagg cggctgtcac acttaattgc caggctgaag 2382001 ctttgaatcc caaacacttg ctttaaatga ggaaaaagag cctcaggatc ctctccattt 2382061 aatgtaatcg tcatacgatc cctgttggaa aagtatttta aattcggata gtctttcaaa 2382121 acgagtctga tgttttgttt taagcgctca ataaagcttt ttctgttttt gcctttggtc 2382181 gaaatttccc caaaacgaat taatatatga tcgtaattca tgttctacct catcatttcc 2382241 cttaattttt tgatgccagg acgaagcgcg ttcataaacg gttctgccac atcgcttgtc 2382301 tggctgtaat ttaaactgat tctgatgctg cttccggcaa tctgctctcc tttgcccatc 2382361 tctaagagaa ccttgctggg cttatgttct tttgccgagc aagccgatgt tgtggagacg 2382421 aatatatcct gttcctcaag catgtgtaaa agcacttccg ctttaatccc cggtacagag 2382481 aaattaataa tgtgcggcgc gctattcatt tgaggcgtgt tgataacgac gccctcaatt 2382541 tcactcagcc tattcataaa caattccttt acggcagtca tcgtgtcaag ccgtgtgtca 2382601 aaatcagcag aggccagatt aatggccttg gcaagcgaaa ccgcaccagc agtatgttct 2382661 gttccggccc gtatgccttt ttgctgagag cctcccgtta tgagcggaat aaggcgtgtt 2382721 ccttctttta caataagtgc gcctgtcccc tttaggccgt gaaatttatg ccccgaaatt 2382781 gaacatagat caatgccggc cttttcaatt gccaagggca ctttatagat gccctgcaca 2382841 taatcgacgt gaaacaaaat gttcgaatgc tctttcagca cttctcctgc cgcttcaatc 2382901 ggctgcacgg aaccgacttc attgttcaca tgcatcatgc tgacaagcac ggtatcggga 2382961 cggatggctg cttttagatc ttcaatagaa acaaatccgt cttcattcac agaaagataa 2383021 gtgatatcaa acccgaacaa ctctttcagc tgttctaacg attccgtaac ggatggatgt 2383081 tcaatagaag tggcaatgat atgtttgcct gtttttatct ttgacaaagc cgctcctttt 2383141 aaagccgcat tattggcttc tgtggcgcct gacgtaaata caatatcata tttttttagg 2383201 cctaaggacc ttttgatttg atttttggct gcttgaagca gctgttccgt ttcggctcca 2383261 tatcggtgca aagatgaagg attgccaaag tatcggctgc tcgtctgttc atatacgttc 2383321 aagacttcat cgtaaggctt cgtcgttgaa ctattatcta aatatatcat cttttttact 2383381 cctttatgaa agcggtacaa ggtatgatat ttatgttacc ataacaaaat ttaatagaaa 2383441 attacgaaaa actagtattg acttctaatt tttttaccat ataataagat ttgttcgttt 2383501 cgtcatatta tctgacaatt aattgacaga atattttaac ataattatta ggaggatttt 2383561 tttcatgaaa cactcactgc ctgtcaaaga taccattatt attggtttca tgctatttgc 2383621 gttattcttt ggagcaggaa atatgattta tccgccggaa cttggacaag cagccggaca 2383681 caacgtctgg aaggccatcg gcggattttt actgacaggg gtaggcctgc cgcttctcgg 2383741 cattatcgcc atcgcattaa ccggtaagga cgctaaaggc cttgctgaca aagcgcaccc 2383801 tgttttcggc acaatcttta ctgtcgtgct ttatttatca atcggaccat tattcgccat 2383861 cccgagaaca ggaactgttt catatgaaat tggcgctgtt ccgtttttga ctggtgtacc 2383921 agaaagactt tctttattaa tatttacact tatctttttc ggcgttacgt actatttagc 2383981 gttaaaccca tctaaggttg tggatcgagt cggaaaaatt ctgactccca tcaaattcac 2384041 aattatttta atcattgttc tcaaagccat cttcacgccg atgggcggat tgggcgccgt 2384101 gacagaagca tataaaggaa caccggtttt taaaggattt ttagaaggct ataaaacaat 2384161 ggacgcactt gcttcaattg tatttggcgt tgtcgttgta aatgctgtaa aaagcaaagg 2384221 cgttacacag tctaaagctc ttgctgcagc ctgcattaaa gcaggtgtga ttgccgcttt 2384281 aggcctgact ttcatttatg tatcccttgc ttatttaggt gcaacaagca caaatgccat 2384341 tggtcctgtt ggtgaaggag ctaaaatttt atctgcgtct tcccattatt tattcggttc 2384401 attgggcaac atcgtactcg gagcagcgat tacagtcgca tgtttaacaa caagcatcgg 2384461 ccttgtcaca tcttgcggcc aatatttttc aaaacttatt ccggcattat catataaaat 2384521 tgtcgttacg attgtcacgt tattcagctt gatcattgcg aatttcggac tcgcgcaaat 2384581 tatcgcgttt tctgttccta ttttatcagc tatctatccg cttgccattg tcattatcgt 2384641 tctttccttc atcgataaga tctttaaaga aagacgcgaa gtgtacatcg catgcttgat 2384701 cggtacagga cttttcagta ttttagacgg tatcaaagca gccggttttt cacttggatc 2384761 tttagatgtg tttctaaatg cgaatcttcc tctttacagc ctcggcatcg gctgggtgct 2384821 tccaggaatc gtcggagcgg ttatcggcta tgtgctgacc ttattcatcg gaccatccaa 2384881 acagcttaat gaaataagtt aatgtcacag aacgcctgcg ttattgcgca ggcgttttgt 2384941 aataaaaaaa gagcctgctc attacactgc gggctctttt tcatggtcgt gattatctaa 2385001 gcggatatgt cagctttgat tttttcaact gcacctggcg cagccttttc tacagcggca 2385061 gcggcaattt cataagagtc gtcataatca aaagcataaa aacgtctttc cgcttctttc 2385121 agctgttcag ataaaatatg attctggctt ctgaaccggt ttccgaactg aatgattttt 2385181 tcaatgagga tgacctgctc gacaagttcc tctgattccc ggcttgccct gttgacgata 2385241 tcttctgctt gtttcaaatg ggctccggct tcttccatat ttaatggaag ttcgtttagt 2385301 tgattgaccg tttcttgaat atgatgatgc gcgttctcca gcatctcttg aatatggctc 2385361 ggaatgcctg gaatgttgct agtcttcagc agtcttgctg tctcagaaat tgtttttttc 2385421 aaattgctga gcgtctccct cgcctgaagc tcttcttttc tcagcgcttg cagattttca 2385481 cgatactcgg catgctcttt tttcacttct tcaatttgct tctctattga agcaacttct 2385541 tctactaaaa gtgagtaggc gacatgctct gcatcaagct tatctttaac ggatgatagc 2385601 agctttccaa tttcatcaag gcgcttttca aaagcctgct gtttgccgag ctcaccggct 2385661 gtcagcctgt agctttcctt caccagctca gtttccgctt tcgtatgctc tttctcttct 2385721 ttaagcttgt cgtaagcaat aatcaattca ggcattttgc ttagtacgga ttgaccggct 2385781 tcaacttcgc cctccagctg ctgataaaca gattgaatat tttcgtcaat gagctgcagg 2385841 attgcggacg cttcatcaat atccagttca gtcatcagga catgttccgc tcgtttcagc 2385901 tggtttgaca gattttctaa ttccttatca agctggatat gctcaagctt gtaccctttt 2385961 tctttcattt cgccatagcc atccttgagc tttgcaatct gtccgggcac cgtctgttta 2386021 cagtcagcta acagcttcgg cacatcatct atgtatgact gaagccgttc aagattgcgg 2386081 tcctgctcaa gcagtacttt tcgtgcagta atatagtttc cgccttctgt ttcttcttca 2386141 aattgtttga tgccgctcca aatttcgtcc agatcctttt caaggctgtc ataaagctcc 2386201 ccgtaaaggt ggctgtaagc cagcaggttt tttcgagatt tcgaatagcg ctccctcacc 2386261 tgttcaatct cttcacggct cttttcctca cttgtgacaa gatcgctgat ttcccgaaga 2386321 atcttttcaa tgcttgattc agccgctgtc agcaggtcgt cgatatgaac gagcacttga 2386381 ttggcctttt taaaccggta tttgtctgca ttttcctcgg catcataaag gagctcttca 2386441 actttcggca tgtgggctgt gacaatctca tcccattctt cacgccactt ctcaaagaac 2386501 tcttctgtct gacccgtcat ttttaaatgt tttattttag acatttcttc cacgatcgac 2386561 cgattcagaa tttcaatctt ccacgattcc agccggtcga tttcggcgta gatttttttc 2386621 ctgaaaaagt agcctgccgc aaacagcgca agcagtacaa ttaataatcc aatgacaaac 2386681 tccataatga gcccccttgc tgtttacctt aatctgtcag ggtgttttat ttattcagaa 2386741 agatttcagg atatgtattg agaaaaactg tcgttttcat tgttattatg ataccatgta 2386801 acaaacattt tttgaccaga aatcaaaaac tttttgtgca aaatcggcag gatttgacta 2386861 ttttttcatg gggtgacatc aatgcaaaag cgagacggac atattcacac accattttgc 2386921 cctcacggct ccaatgacac actcagacaa tatgcagaag aagccttaaa aaaagggttc 2386981 gaatcgatta cttttaccga acacgcccca ttgccgccat cttttaccga tcccacgccg 2387041 ctgaaagaca gcgcgatggc gcaagcttct ttggaacgct atattcatga aatttccgga 2387101 ttaaaaaaag aatatcgcgg acagcttagc atacggacag ggcttgaagt cgattatatc 2387161 gctgaatttg aagacgaaat tacattattc ctagacacat acgggccata tttagatgac 2387221 agcatcttat ccgttcattt tttgcgcaca gactcttcct atctatgcct tgattatgac 2387281 gagcatacct tcaaagagct gatttcagcc tgcggaagca ttgaagcggt atatgaacaa 2387341 tattaccgga gtatctattc ttccattgta gcatctctcg gcgtttataa gccaaaaaga 2387401 gtcggtcaca tcacactcgt ccaaaaattc atcaagctgt ttccatacag catgtcagag 2387461 catattcgcg gcctcgtttc tctgtgcctg aatgccattg aagaaaacgg aatggagctc 2387521 gacttcaata cttccggctt aagaaaaact tacgctggcg gtatttatat cgaggattgg 2387581 atgctgaatg aagcgaagca aaagaagatc ccgcttgtgt ttgggtctga tgcccatcaa 2387641 gcgggagatg tcggatatgc gtatgaggcg tttttggaac ggtgctagtt ggtgagcgcc 2387701 acgtctcctg tccggaagac gcttctgatc caaatcttga tttcttcaaa atacatttta 2387761 taaaaatacg gctcgtgcgg ctgcatgtag agtacttctg aaatatattg aggctggaga 2387821 tagggcatca tcaagagaga ttttaattgg agaataaaat gaggcagcgg cagcgttaaa 2387881 tattcacgct gtttttctcc ttcctcaatg atcagctgga agatatactt ttccttcatt 2387941 agatatgtcg acataatttc cctgattaat gtggagtcaa ttgtgacttc ccggtagaca 2388001 aaacgagtta attgacgatg attatgctga taggataaaa tatcgaaaac caattgaaga 2388061 agctgttcct gcgtgctttg agtagagata ttgcttgccg ctgtttcaag cgttttgctg 2388121 tagccttcgt aaaactctga aactaagtgt tccatcaagc ctcctttgcc tttaaaatag 2388181 taggagatgt gcgcaacatt tacatcagct gactttgcga tttcacggac agacgtgcca 2388241 gaaaatcctt tttggttaaa aagcatgaca gcagattcaa taattttgtc tttggtgctt 2388301 actttcatac ggctcactcc ttcctcttga tactattcaa gcagaaagcc gctgttcctg 2388361 taagaactta tcgacaaatg ccggcagaaa agccggaact ttgttttata ttatagaaaa 2388421 agtgagggtt ttccatgttc catgtcgaaa aacaatctgg agataaagaa aaagactatc 2388481 agcttctgct aaaacagctc gaagccatga ccgaagacga aacagaccaa atagctaact 2388541 atgcaaatgc ctcagcactg ctgtatcatt cgctgcctga agtcaactgg gcgggtttct 2388601 attttgccaa agaagaggat ggacagcttg tgttaggtcc gttccaaggc ctgccggcat 2388661 gtgttcggat tcctttcggc agaggggttt gcggcacagc gtacgcaaac ggaaaagtgg 2388721 aacgtattga ggatgtaaac gcgtttccgg gacatatcgc ctgcgatgca gcgtctcaat 2388781 cagaaattgt gcttccgatt cgtgtagacg gaaaaattgt cggcgtcttg gacatcgaca 2388841 gcccagtgaa aaaccgtttc gacgaaattg atgaaaaata cttaactcaa tttgccgaaa 2388901 cgctagaaaa agcgttagcg cagtaatata aaagcccaaa actgatatcg ttttgggctt 2388961 tttttatttt attgagtcat gaatcatcaa gcggtttttc ccgctccgtt tcgcgctgta 2389021 gagcgcttca tctgcctcat gcacaagctc tttcagcgac ttttttgttt ctgtcgtcca 2389081 gcaggagata ccgcaggaaa tggttacctc gggtttcgta ttttttctga ccgcgtaaac 2389141 cagtcgctcg gtaatccgtt tccccactgc aaccggcaca tttggcaaat aaatcgccag 2389201 ctcctctcct ccccagcggg caccgacatc atgctttcgg atgttgcttt taatcactga 2389261 agcgacttga attaaaatct cgtccccagt ctgatggccg tacgtatcat ttacattttt 2389321 aaaattatca atatcaacaa gaataaaaac acccttttga tggattttca tgctgtattg 2389381 aattttttca tctaaatacg ctcgtgaata cagttcagtc agctgatctg ttttcacgag 2389441 atgctcaagg cggtcgcgaa gcattgaatt ggttacagcc agtgtcgcgt gatgaatcag 2389501 cgcctgaaac agcttgtaca tttcaaatgt aaaagcgtac agctcctgtt tcaataaaac 2389561 cgcaaagcct aaaagccggt cgttttgaat catcggagca gccatcagcg agccgtaccc 2389621 cgccttccca aaaacagact ggccattccc gatgaaaacc cctttttcac cttcatacag 2389681 cttttctttc agctcattat aaaaatctga cggcttcgct tctttaaaaa atgctgtgct 2389741 gcctgggagc aatgttaggt tttcaaaatg gtctatatga aaaaatccca cttcttctgc 2389801 ctgaaacgat tctgccattc tcacagccag atcattcatt gtatcagtca atgtcagccg 2389861 ctgattcagg cgtcgtgatg tttcattaat caattccaaa tttgcgatgc ttgctttgga 2389921 ttgttcgtag agctgggcat tttcaaacgc ttttcccgcg gcgtttgcta acagcgacat 2389981 ttcatcaagg caggcatcag taagaaagct gtcacccgtt ccttcagcct tcaacacccc 2390041 gtatgtgccc tgctgtcctt tgatcggaat ataggcgaca gattcatttt tccgcaaaat 2390101 gtctccggac aaatacactt tgagcgcaaa ggaatcggat ttttcccctt ccatatacag 2390161 ctcttttgca ggaatcccta aacattggtc ttgatcgtgc gatataaata aagaaaactc 2390221 aaaaagagaa aatgtgcttg tcaagctttc taaaagctgc ttcagcacat ctgtctgatc 2390281 aagcagtgaa tggaacagct ctgtcatttt gtatatcttt ttttggtaga tcgttttgtt 2390341 atagagtctt tcctgtttca tcgactggtt taaaaatgaa gcaaccacgt ccggaagccc 2390401 ttcaggaatc tcttcatcct gcctgcacgc aagatggaaa cgcctgccgg agccgtcctc 2390461 aatcagataa catgaagcgt ttatttttga agcggaaaaa cgcgcttcac catctgccag 2390521 ttttgtcaca aagtctgatg gtgacggtgt aagcgaaaca caaagggttg aaaaataggt 2390581 ttgaatagcc gaagtcagcc atatgaaaga gtcggtgaat gtgacttttt cagatttggt 2390641 taataaaaaa tcgagcatat gataatgaaa ggcggataat tgatctttag tttgttctac 2390701 catgttttta tcacctaaaa gtttaccact aatttttgtt tattatatca taaacggtga 2390761 agcaataatg gaggaatggt tgacttcaaa acaaataaat tatataatga cctttgtgtg 2390821 aaatattgca gcctttttgt tcagcttcta tgttttcatt ttgttcctta tcaataaggt 2390881 gtatcgtgta actctctgct gctggagcga ggatacatga aaacaaaatg tgcatggtcg 2390941 aatagagcag acggttttta ttttccacaa aaataaaacc aaaggaggag tcacattatg 2391001 gctcgctata caggtccatc ttggaaactg tcccgccgtc taggaatctc tcttagcggt 2391061 acaggaaaag aattagaaaa acgcccttac gctccaggtc cacacggccc aggacaacgt 2391121 aaaaaattat cagaatacgg tttgcaattg caagaaaagc aaaagcttcg tcacatgtac 2391181 ggtgtaaacg aacgtcaatt ccgcactttg tttgacaaag ctggcaaact agctggtaaa 2391241 cacggtgaaa acttcatgat tcttttagat tctcgtcttg ataacgttgt gtacaagcta 2391301 ggtttagcac gtactcgccg tcaagctcgc caattggtta accacggtca cattcttgta 2391361 gacggaagcc gcgttgacat cccgtcttac ctagtgaaac ctggtcaaac aatcggtgtt 2391421 cgcgaaaaat caagaaacct ttctatcatc aaagaatctg ttgaagtgaa caacttcgtt 2391481 cctgaatacc ttactttcga cgctgaaaag cttgaaggta ctttcactcg tcttcctgag 2391541 cgttctgaac ttgctccgga aattaacgaa gcgcttatcg ttgagttcta ctctcgttaa 2391601 tcgttttaaa aacccctgcc gctatgcggt cggggttttt ttatcggctt tcgcctcttg 2391661 ctggccaaca ctatcttgcg cctgctgctc ccaatgatcc cgctgcagcc gttcttttgc 2391721 aatcgtacac atgagattca cgctttagcg ctcctttcat ttaaaaggtg gtgattggtc 2391781 gtgtttgccc tatctaatat actcttttcc tttcattcct atgcggtaaa caaaaagatc 2391841 ctttgccttc agtggcaaag gatctttttc ttatttatac gtcacaagga agtatttttt 2391901 cttcccgcgg cgcagaacag taaattggtt ttcgatgcgg tcttcacctg atagggtata 2391961 atttatttcc gtctggcgtt caccgttaat gtaaacagct ccgttttgga tgtcttcacg 2392021 cgcttggcgt ttagaaggag ataatttaga ttgcaccaac acatctacaa gtgaaagctc 2392081 ttgggtgctg tcaacttcca tagaaggaac atctttaaag cctactttta cgtcttgagc 2392141 agaaagctct ttaatattgc cgctgaacag cgcttgggag atgttgatgg cttgctccag 2392201 cgcctcgcgt ccgtgaacaa gtgatgtcac ttcttctgcc aggcgttttt gcgcttcacg 2392261 tttttctggc gccgtttctg ttttttcagc gtatgcttca atttcctctt ttgaaaggaa 2392321 cgtgaagtat ttcaagtatt tgacaacgtc acggtcgtct gtgttgatcc agaattgata 2392381 gaattcatat ggcgatgttt tttctttatc aagccagatc gcgccgcctt ccgtttttcc 2392441 gaacttcgtg ccgtctgctt ttgtgacaag cggaatcgtt aggccaaacg cttttgctcc 2392501 ttcttcttct gattttctga tcagttcaag acccgctgtg atgttgcccc actgatcgct 2392561 tccgccgatt tgcagtttac agtttttgtc tctgtaaaga tttaagaaat cataagattg 2392621 aagaatcatg tagctgaatt ccgtgtacga gatgccggat tcaattcttg agctgaccgt 2392681 atcttttgcc agcatgtaat tgatgccgaa atttttacca acgtcacgaa ggaaatcgat 2392741 cacattcatt ttgccgatcc agtcaaagtt gttcgcgatg acagctgggt tttctgctgc 2392801 ttcaaaatct agaaatctgg acagctggtt tttgattttt tgggaccatt cggatacgat 2392861 gtcagcagtg tttaatgtac gctctgcttt ttttccgctt ggatcaccga tgaggcccgt 2392921 cgcgccgccc acaagcgcaa tcggatgatg ccctgcaagc tgaaaacggc gaagtgttaa 2392981 aataggcagc aggtgtccga tatgcaagct gtctgctgta gggtcaaagc ctgagtacaa 2393041 gcggattttt tcttcattca gctgtttatt taacccttct tcatctgtca tttgctgaat 2393101 caatccgcgg aaggataagt cttcaagtaa gttagtcata agataaagct ccttttttaa 2393161 ttaaaataaa aaacgcccct tcgtttacac gaagggacga ttgattatcg cggtaccacc 2393221 ctactaataa gagaatgcaa acattcgtct tatcactttg cctgataacg gatcaggtcc 2393281 gttctttcac tactgaaagc ctggccggct ttgtttgcaa aagcggttca tgagtgtatt 2393341 cgatatatcc gtctgtgctg attttcaccg gccatcagct ctctggaacg taaggatatt 2393401 ctacttgtct caatctttac cttttcatat gaagctatat catttttaac ataaataaaa 2393461 tcctgtgtca acgccgcctt ttaatcctcc attgttgaca gatctccagc cggcagatta 2393521 agctcccatg ccttcagcac gcgcctcatg atctttccgc ttctggtttt cggaagctta 2393581 tctttaaatt cgatctcacg cggagccgca tgggctgcaa gaccctgctt tacaaatagg 2393641 cggatctctt ctttcagttt atcagacggc tcaaatcctt ccctgagtgc aataaaggct 2393701 ttaatgattt ctccacgcac cgggtcaggc tttccgataa cgcctgcttc tgcaatagcc 2393761 ggatgttcga caagcttgct ttccacttca aatgggccga cgcgctcacc ggaggtcatg 2393821 atgacgtcat caactctgcc ttggaaccaa aagtatccct cttcatccat gtaagcagaa 2393881 tccccagaca cataccagcc gcccggcatg aaatacgatt catacttttc agggttattc 2393941 caaatggtat gcatcatgga aggccagccc tttttgatgg cgagattgcc cattcggtac 2394001 ggcggtagct cgttgccttg attgtcaacg atcgctgcct ccactcctgg aatcggctta 2394061 cccattgaac ccggtttaat atccatgcaa ggatagttgc agatgagctg actgcccgtt 2394121 tcggtcatcc accaggtatc atggattcgt ttgttaaaaa ctttatgtcc ccatctgatg 2394181 acttccggat ttagcggctc accgacactg agcacatgcc ggagtgaagt tagatcatat 2394241 ttcgcagcca tttcatctcc cgctcccatc agcatccgaa aagctgtcgg cgcgctgtac 2394301 cagacattga cgccaagctg ttcaatcgtt ccataccagc tttccgggct gaaacgtccg 2394361 ccgacgatga catttgtcgc tccgttcagc cacggtgcaa aaatgccgta taccgtacct 2394421 gtcacccagc ctggatcagc cgtgcaccaa taaatgtctt cttcctttaa atcaaggacc 2394481 cactttcctg tttgatattg ctgaatcatc gcttcatgga catgcaacac gccctttggc 2394541 gtaccagtgg aacctgatgt atagtgaagc agaaagccgt cttttttatc catccattcg 2394601 atatccaatc ttgtgctttc ctgtttcgct gcttcatcat aattgatgat attcgtgccg 2394661 ctctcagcct ctcccccgac tacgaagaca tgctgcaagt gaggcagttt gtctaccggt 2394721 attctctcca gcagctcagg cgttgtgaca acaacctttg cctcactgtt ttcaagccgg 2394781 tctttcaccg ctccctccat aaatgcttcg aacagcggcc cggcgatggc gccaattttg 2394841 attgcgccaa gcataataaa ataaagctcg ggtgatctcg gcataaaaat aaaaacgcgg 2394901 tccccttttt ccacatttcc ataccgtctc agcacattcc cggctctgtt tgattcttcc 2394961 ttcatttctt taaatgtgta tttttcatcc ctttttgcgt ctttataata aagcgctact 2395021 ttgttttttc gaaacgattc ggcatggcgg tcaatcgctt catacgccgc attcagtttc 2395081 cctgtctcat gccaagagaa atgtttctct gcctcggccc aatcaaaatg ccggtacgtt 2395141 tcttcatagt tttttaagtt atgatccccc tctattgctg gtaacgcttt caagttcatg 2395201 cccaaacatc cccctttgct gaagttgtca caattattat agtatatatt catattcttc 2395261 tcaattttta aaatataaac catgttgaaa acgctttata atttggtatt cttaaagaag 2395321 gcatgtattt ttgataagaa ttgatgggac ggtgaattag tggaacatca taaaacatac 2395381 cattcagcaa acatcaaaac agcaaccggc tctttactga tagaagggcc tgtctctcca 2395441 gaggatttgg caggttatga gtttcataaa gatttaaccg catttcgccc gcctcgcgag 2395501 cagcatgaag cgctagtcga cattgcaggc cttcccgaag ggcgcattat tattgccaga 2395561 gacggccgaa ccattgtcgg ctatgtcacg tatttatatc ctgacccgct cgaaagatgg 2395621 tctgaaggaa atatggagga tttgattgag ctcggagcca tcgaagtagc gccggactat 2395681 cggggatgcg ctgtcggaaa gacgctcctg accgtcagca tgatggatga acaaatggaa 2395741 aactacattg tgatgacgac agaatattac tggcattggg atttaaaagg gatgaaaaaa 2395801 gatgtgtggg aatacagaaa gatcatggaa aagatgatga atgcaggcgg attggtctgg 2395861 tttgcaacgg atgagccgga gatcagctcc caccctgcaa actgtctgat ggcccgcatt 2395921 ggaaaaaacg tcagccaaga atcaattgag caatttgaca ggctccgttt ttatcatcgt 2395981 tatatgtatt aactgacact gacaaagggg aaaaaataat gattgttgag caaatcatga 2396041 aaagagatgt cattacatta acgaagacgg atacgcttga aacagcaata tgcaaactga 2396101 aggaattcca tatcaggcat ctgcctgttg tagatgaaga acgacacgtg atcggcatga 2396161 ttacagacag ggacatgaaa caggccagcc cgagtatttt tgaagaaaac aaacgaagcc 2396221 tatttctcac acgaagcgta gattcaatta tgaaaaagga tgttgtctgc gcccacccgt 2396281 tagattttgt cgaagaaata tcagccgtgt tctacgagca tggcatcggc tgcctaccag 2396341 tggtacacca tcaaaaatta ataggcattt taacaaaaac cgatttgctg cggacgtttg 2396401 tcaaattgac aggcgctgac cagccgggct cgcaaattga gataaaagta aacgacatca 2396461 ccaaaagcct cgctgagatc agcagtcttt gccaagacct tcaagtgaaa atattaagcg 2396521 tgcttgttta tccgcatgac gatcccggtg taaaagtgct tgtcttccgt gtaaaaacga 2396581 tgaatccgct gccgtttttg caggcattac aaagaaatgg acaccacgtc gtatggccgt 2396641 cagagcaaag ggatctgcta tgagagacag tgtatttatc tattctccat cctaccaaac 2396701 ctatatgttt catcaggagc atccctttaa tcagcagcgg gttctgttaa catatgattt 2396761 gcttaagacg atcaatgcct ttgatgatgg agacattgtc acccccagac tcgcttcaga 2396821 agaggagctt tcccttgtcc acacggacga ttacattcag gccgtaaagc ttgcgggcgc 2396881 cggaaagctc cccgctgaag aaggagaaag ctacgggctc ggcactgaag acacacccgt 2396941 ctttgccggc atgcacgaag cggcatcact cttggtcggc ggcactttaa cggccgcaga 2397001 ctgggtcatg tcaggacaag ccctgcatgc ggcaaacctt ggcggagggc ttcatcacgg 2397061 ctttcgcggg agagcatcag gattctgcat atacaacgac agcgctgtgg ctattcaata 2397121 tatccagaaa aaatatagcg ccagagtgct ttatattgat acggacgccc accacgggga 2397181 cggtgtgcaa tttacatttt acgataatcc tgacgtatgc acgctgtcca ttcatgaaac 2397241 aggaaggtat ttattccctg gaaccggtca gatccaagaa aaaggaagcg gaaaaggata 2397301 tggctattcc tttaatattc cgcttgacgc ttttacagag gatgattctt ttcttgaggc 2397361 ttaccggaca gcagcttcag aagtcgccgc gtatttcgag cccgatgtca ttatcagcca 2397421 aaacggcgcc gatgcccatt actacgaccc gctgacgcat ttatcagcaa caatcaatat 2397481 atacgaagaa atcccccgtc ttgcacacac tttggctcat caatattgcg gagggaaatg 2397541 gattgcagtc ggaggcggcg gatatgatat ttggcgtgtc gtgccccgcg cctgggccag 2397601 aatatggctt gaaatgaagg gaattgaccc gggtcacgag atcccgccgg aatggattgt 2397661 taaatggcaa aaacaatgcc ccgtggccct tccgtcgagc tggagcgatc cggctgattt 2397721 atatcctccg attccccgca agcctgaaat tacagaaaaa aatgcccaaa ctgtcagcaa 2397781 agcattatat gcgatacgtt ctgaacagca aagaacaaag taaaaaacga cctttacgaa 2397841 gaggtcgttt ttgatttttt aatcactatt tccacacgcc gattttcctt catgtgttca 2397901 tttgtcttgt tatcctttac tggctttgta tccgcataac cgacagcaat aaagcgcttg 2397961 gagggaagct tctctttaga cgtgaagtat tgaatcactc cacttgcccg tgctgctgat 2398021 agctcccagt tcgacgggta tcggtatgtc gaaatgtttc ggctgtctgt atgtccctca 2398081 acctgaatgt catttggaat tgtttgaaga agaacggcaa tttggtgaag aagtgtttcg 2398141 gcatttttca gcacctttgc ctcacctgta tcaaacagca cagcctcctg aagaacgagc 2398201 acgacaccgc gttcatcccg tttggctgtc atttgggcct tcaaatgatt gtcttttata 2398261 tatgtattta ctttcttgag aagctgatcc tgctgatcct cttgcttctt cgtatcagat 2398321 ggggatgtat tctttttttc tatggatgtt tggtccggct gaagcccgtt gccttccttc 2398381 tggatcgagt ccactgccgc tttgaatttt tgcagatcga tttgggacat cgaaaagagt 2398441 aaaataaaga acacaaggat caaggtgatc agatctgtaa aggttaccat ccagctggat 2398501 gaagattgac tgttttttcc gcttccattc cttctttcaa aacgttctct tctaagcttc 2398561 atgtacagat cccttttttg tttttacttg ttttggctgc ttctgccatt cttcccgtga 2398621 gctgaaaacg accagctggc tttcaaggtt gcgcgggttt tttccggatt gaacaccgat 2398681 aatcccttcc accattacct gcttgatgaa aatttcactt tctgttttct cttcaagctt 2398741 agccgcgatc gggttgaaga ccatatttgc cagtaatgaa ccatataaag tcgtcagaag 2398801 cgcaatggcc atgtttggtc cgagcatatg cgggtcgttt aagtttttga gcatcagcac 2398861 aagcccgacg agtgttccga tcattcccca tgccggagcg aattctcccg ctttttcaaa 2398921 aactcgccgc ccttttcggt gccgttcctc cattgctgcg atttctgaat ccatgacgag 2398981 ccgaatcgtt tcttcatccc agccgtcaat cgctaaaagc agcccttttt tcaagaatgg 2399041 atctttgatt tcccgagcct gatcatccaa tgataaaagc ccgtgttttc gcgcgtgatc 2399101 ggaaagggaa acaaaggttt tcacaagatc tttcacattg tcttcctggc ggatgaatgc 2399161 ctgctttaac acagagggcg cttttttcag ctcacttggc ggaaaactga taaaaacagc 2399221 ggcgcaaagt ccccctgtta cgatgaagaa agaggtcaga tcaagaaaag agcggaaacc 2399281 gcttactccc gatcctgaaa taatcccgat aacaataata atcgttccta acacaaatcc 2399341 aacaggtgta agataatcaa aacgtttcat catttctccc catgaaaaaa gcaagaattc 2399401 accataaagg tgaagcttgc tctttgtttt tcttatgact tggttgactt tctaagctct 2399461 atacggtgcg gcagttcgac gatatgctct tcaaccggct ctttattcat gagcttcgtc 2399521 agcagtctca tcgcaacggc gccgatatca tatgtcggct gaacaactgt tgaaagctga 2399581 ggacgaacca tgaggcttaa tcttgtatta tcaaaaccga taatgtcgag atcctccgga 2399641 atggataagc cctgatcctg agcggcatgg ataatgccga gtgccatttc atcagttgca 2399701 gaaagaatgg ctgtcggttt tttatccagg ctcatcagat gctgcagtgc ttcgagtccg 2399761 gaatcatatg tgtaatcccc ttcagctaca aattgttcat taaacggaag gttcgcttct 2399821 tcaagcgcac gtttgtagcc ttggagtttt ttcgaacggt tgatcggttc tgccattggt 2399881 ccggaaacga acgcgatgtc tgtatgtcct ttatcaacca aaagcttcac ggcatcataa 2399941 atcgcctgtt cgtaatcgat agcgactgac ggtgtttcct cctgctcttc tacagaagcg 2400001 gcaagtacaa tcggcactgg agaacgctta aattccgcca catgctcgtc cgtaatgttt 2400061 ccgcccataa acacgatgcc gtccacttgt ttgccgagca ttgtgtttaa caagtgcagc 2400121 tctttctcca tgttttggtc agagttgctc aaaataatat tgtatttata cattgtcgcg 2400181 atatcttcaa ttccgcgcgc aagctctgaa tagaaaatgc ttgagatatc gggaatgatg 2400241 acacctacag ttgttgtttt tttacttgcc agccctcttg ccaccgcgtt tggacggtaa 2400301 ccgagacgtt caatggcttc caagactttt ttcctcgttg tcggttttac attcgggttg 2400361 ccgttcacga cacgggaaac ggttgccatg cttacattag cttctctcgc tacatcgtag 2400421 atcgtaatat tgctcatcct aaaaccactc cttttactgg atacacttat ccttatctat 2400481 agcataaaca ctttatgtag agaaatgtca taatgtccga atttatgtcg tttatgattt 2400541 gtaagcgtaa gtcagtagtg tacattattt ttcattattc atcaaattta attacttctc 2400601 atgaaattat acacgttttt atagatgatg aaaacgtata cttggttttt ataactaaat 2400661 aaacgagaaa gcataaaaaa aggccgcagg cgcggccttt tggattgttc aattaagcgt 2400721 tgactttcac cattggcttc agttcattca gccatttttc gaattcagga atcgccattt 2400781 gctgagcaga gtcagaaagt gcgactgacg gatcagggtg aacctcagcc attacgccat 2400841 cagcaccgat cgctaaagcg gctttagctg tcggaagcaa gaggtcacgg cggcctgttg 2400901 aatgcgtaac atcaacaaag actggcaaat gcgtttcttg tttcaaaatc ggcacagctg 2400961 aaatatccag cgtgtttctc gttgctgttt catatgttct gattccgcgc tcacaaagga 2401021 taatttggtc atttccttgt gacatgatgt attcagcagc attgatgaat tcagagatcg 2401081 ttgcagcaag accgcgcttc agaagcactg gctttttcac ggcgccggcc gctttcagca 2401141 attcgaagtt ttgcatgttg cgcgctccga tttgaatgac atcaatgtag tccagcgctt 2401201 cttcgatatg agccggagtt acgatttcac tgataaccgc cagatcaaat tcatccgcta 2401261 cacgttttaa aatttgaagg ccttcaacac caagcccttg gaaatcgtat gggctcgtac 2401321 gaggcttaaa ggctccaccg cgcaaaattt taatcccttg ttttttcgca gctgcagcga 2401381 cttcagctac ctgctcatag ctctctaccg cacatgggcc gacaatgaat ctttgctggc 2401441 cgtctccgat tttttcgcct ttgatatcaa caattgtatc ttcaggtttt ttcttgcggg 2401501 agacaagcag cgctttgctg tgatcttctt cctgaagctc taaaccggct ttgaatatct 2401561 ctttaaaaat gtgctggatg gttgaatttt cgaacggccc gtcattgttt tcaatgatat 2401621 tgtttaacat tgtgcgttct ctgacagggt caaatcggtt gacaccctgt gcttccttcg 2401681 ctttaccgat ctcttttaca acattgccgc gttcgttgat taattttaaa atttgtaggt 2401741 ttaattcgtc tgctttctgc cttaaaagct ctaactctgt gttgctcatt tttttcatcc 2401801 tttccctgca cattcatttt ttattttgta gttatcatgc atcttactat aagtaattcc 2401861 aaatggaaat actgaaatac aaaaaatttt ataaaaactc tactttatta cccaaacgct 2401921 tttaagtgat aaagtaatct atgaagctat cctacatgat gtgagggcaa tgttcaaggg 2401981 ttttttacaa aaaaaagcgc cagatgatat ctggacgctt ttttctatga caaatgctgc 2402041 tcaatagcgg cttctgtaat ttgtgaatgt gaggtatgcc atttcacttc accgttctgg 2402101 atgatgaata tctgagggct ttcatgcttg accccatatg tttctgcaat gaaattggac 2402161 agcggccggg cttcttgtac ttgaagatag taagccggca catcctcatg ctgatttgca 2402221 aaggcatcaa actcatgaaa tgctgcctgg ctgatcgggc atgtggtgct gtgtttcaag 2402281 aagacgaaaa cgccttcctg ttctgcaatc cgtttaaatt cttcctcaga ttgaataagc 2402341 tgtttagcca tgactcaagc tcttccttcc ctgctcagcg attcaactgc tcagcctgtt 2402401 tttgtgcatc tttcagttcg tcttttacat cttctttcgt ctggaggact tgatcttttg 2402461 tttcatcagc tgcctgcatc gcttcttccc tcatatcttg cattgcagtc gatgaatccg 2402521 ttttgtcaga tttggaacgg tctctcaaat cctttacctt gttcatgatc tgtccagact 2402581 gatccgctac aagctgtgtg atgttggaag ttttgtcttt tgcgatgctg acatattgcg 2402641 tgcctttttc cttcgcatct gccgtcattt tatcagtttt gtcccgtaag gcaacagcct 2402701 ggctgccgag atcgtcgcga agttctttgc ctgatttagg cgctagaaaa agagctgtag 2402761 tggcaccgat gattcccccg attaaagttc cgattaaaaa atctttacta ttaattccat 2402821 ctttgctcat cattattcct cctcttagta tttttttctc ttacagggct gattttttct 2402881 tttgcttcca tttctcccaa atttccattg ctgcttgact ccaagtgaca acttgattga 2402941 tcttatcttg attctctcta actgatgccg atacagaccc tgccgcttgt ttcatggatg 2403001 tattgaactg ctgtacagaa gctcccactc cttgaacagc atgaacgacc gtgttcagct 2403061 tttctgattt ttcctgaata tcttcagcca ggcggttggt cttatgtaaa agctcggctg 2403121 tttcagttgt gatgcccttc atttgtccct ccagcccttc aagagtggat gcgacgtttt 2403181 ttagtgtcag ctgcagtgac ttcaatgttt tagacaagta gatcactaat acgagaaatg 2403241 caactgcgat gagtgcaacg ctcaaataaa gaataataat catctcaaac ctccttgctg 2403301 caggatatac tgctgtttac ccgttttctt caatcataaa catgtgtact gggctgtata 2403361 catactattc tccgttatgt aagaaaatcc tttaataagc tttcccatca gataaataaa 2403421 aagcagtgag atcactgctt tttattatgc catgacgttt tcgtaggctc tcatatattt 2403481 ttggatatct cctgctccca tgaagatgag aacggcttta tcatgagctt ttaaaacaga 2403541 tgtgtcatct tcttcaatca gcttggcatt atgaattttt ccctggagat caccgatcgt 2403601 cagctttccg gcattctcac gggctgagcc gaaaatatcg cataaataca cacagtcggc 2403661 gccgctcagg ctttctgcaa attcgtcaag gaactgctgc gtccgggtaa atgtatgagg 2403721 ctggaatacc gcgacaattt cccgatcagg atacttctgt cttgccgcct cgattgtcac 2403781 ttttatttct gtcggatgat gggcatagtc atcaatcagc acttgatccc caagctgctt 2403841 ctcattgaat ctgcgtttga cgcccccaaa ggatttgaga gcatgcttaa tgatgctgga 2403901 atcaatttct tcataatggc ataacgcaat gaccgccaat gagtttaata cattgtggtg 2403961 gccgtacgca ggaatataaa acgtatcata gaacgtattg cggacaaaga catcaaaagt 2404021 tgtcccttcc gtgcttttta cgatgtttct ggcttgaaaa tcattttctt cccccgtgcc 2404081 ataatacaca accgggacgt tcgcatggat tttcggcaga tgctcatcgt ctccgcaggc 2404141 aataatgcct ttgttgactt gaagagccat ctcttggaaa gcgtcaaata catcgtcaat 2404201 gcttgagaag taatcagggt gatcaaaatc aatattcgtc ataatcgcat aatctggctg 2404261 atagcttaag aaatggcggc ggtattcgca cgcttcaaac acaaagtatt cgctgttttc 2404321 atttccctgg cctgttccgt ctccgattaa gaaagacgtc ggttttgcgt tttggatcac 2404381 gtgagccagc agacccgtag tcgacgtttt gccgtgtgcg cccgtaacgg caacactcgt 2404441 gaattttttc atgtagtcgc ctaaaaactt atgataacgt atcaccggaa ttccctcaga 2404501 catcgctttt tctatttcag gatgcgtgtc tgggaatgcg tttccggcga tgactgtcat 2404561 gccgggttta atattttccg cgctaaaagg aagaatcgta atatttcttt tttcaagcgc 2404621 tgtttgcgta aaaataaatt tttcgatatc cgatccttgg acagtatatc cattatcatg 2404681 aagtatttgg gcaagcggac tcataccggt cccttttatt ccaacaaaat gataaacagt 2404741 cataattgta cctccaacaa acgtctatct gttccccagt atatgacgct catttcaatt 2404801 tgcgaccgcg gcggctgaaa agcctccctt agcggcgtat tttatatgtt ttgttatgtt 2404861 tagtatcagg ttatttcttt ccgattaaac ccagatatca agatttgtct atgcacagct 2404921 gctgtaaagc ggcatagctg ttaaatgctc taaacactat cataccatgt ttggtgtgaa 2404981 aatgaaccca tattattcgt ttattaaatc acttgctgtg atcagcacct ctcgaggctt 2405041 gcttcctttt gcctcagaga tcatgccttc cgcttccatc atgtcgatca gccttgccgc 2405101 acgattgtaa ccgattctga atcttctttg caggcttgaa gtgctcgcac tgttttgctc 2405161 tacaacaaac tcacacgctt cgtaaaacag ttcgtcctct tctttcaggg cagatccttg 2405221 tcttacgagc tcttcttgtt caaataaata ggtcggcggc atttggcttc tgacgtggga 2405281 aacgacgcgg tcgatttccc ggtctgacac aaagttacct tgcagacgaa ccggttttcc 2405341 cgagccgttt tccaaaaaga gcatatcccc ttttccgaga agcttttctg caccggctat 2405401 atcaataatt gttcgggaat caacctggct tgagacagaa aaggcgattc tcgttgggat 2405461 attcgcctta atcagacctg taatgacatc gactgacgga cgctgagttg cgacgagaag 2405521 atggataccg cacgctctgg ctttttgggc gatccgcgca atgctttctt ccacatcgtt 2405581 tggagccacc atcatcaaat ctgcaagctc atcaataatg acaactaaat acggcagctt 2405641 ttcacccatt tggtgttcag cggttaattg attaaagcgg tcaatgtcgc ggacacctga 2405701 atgggcaaaa agctcatagc ggcgctccat ttcctcaacg acccatttca aagcagccgt 2405761 agccgcttta gcatcagtaa tgaccgggct gacgaggtga ggaattttat tgtaaggggc 2405821 cagctctacc attttcggat caatcagcag cacctttacc tcactcgggt cagctttata 2405881 aagcaggctt actaatattg tattgatgca tacgcttttt ccggagcctg tagcgccggc 2405941 aatcaagcca tgcggcattt tcttcaagtc gataacaaca ggatttcccg aaatatctaa 2406001 tcccagcgca gctgtgagcg gtgacttgct tgtcctgaaa gctgagctgc gaatcatttg 2406061 gcgcaaatca accaccttgc tcgtgcggtt cggcacttca attccgatcg tgtttttccc 2406121 cggaatcggc gcttcaatcc gaatatcttt agctgagaga ctgagtttaa tatcatcgga 2406181 caagttggtg attttattca cctttacacc cggttcagga tgcacttcaa atctcgtgac 2406241 agacggaccc tgggttacat ggaccacatt ggcgcggaca ttgaaatttt tcaaggtcaa 2406301 atcaagaagc tgacgctgtt cttcgatcca cgcagtatca tcttgaacct gcgctggcgg 2406361 gacatcaagc agtgcaacat tcggaaatac atagctgccg cggcgctcct ctgctttttg 2406421 ctgtttatgc gtatctcttt tcagcatcat cacattaaaa ggaacggatg gccctttttg 2406481 agaagatgcg ctttgttcag tccttttctc ctgtacacca ggcctttttt tcggctcttc 2406541 tgaagcttcg cgaggtttgt ctgcgcgaat ttcctgccgg ttttcaagag ttgcagtaga 2406601 cgatttggaa ccctgctcca tgtgttcagt tttctcaagc tctgtatggc tgtctggctg 2406661 aacatctatc ttcgtttcct gagcctctcc cagggtgtca taatgattat ttattatgct 2406721 ttctgatggc tcttctgatt cttttgccac agtttctgct tgagccagag cctctgatga 2406781 atactcatga tcagtaaata aaggctcttc ctgacgaatg tccatttgtt cttcttgaac 2406841 gaacggggac tcagcacctt ctgccgcgtt ttcatgatga ttgtatactg ggctgtctga 2406901 cggctctttt gctttttcat cctcagatac tgcctctgtc tgagattcag gagctgtttg 2406961 ctcttcatca agttcagcgg agaaaacagg ctcttcaaat ttctctggct gctgctccct 2407021 ttgttcttcc tcagccgttg caggctcttc gcggcctact tcactgtctg aaagcccttc 2407081 agccgccgta tctgtgagca tctcaggcgg tgtttgctct tcggcttgtt cagctgggaa 2407141 gaaaggctcc tctttttccg gctgttgaac gcctgactca aatggcactt tgttacctga 2407201 cggctcggct ggccgtttcg ccagcgcctc atcatgctcc gtatcctttc tgtttaaaac 2407261 gccagaaggc tgtttttcaa attgggtatc cgggaagaaa ggactttcta ttttggaatg 2407321 cgcctgtgtg tctgaagcag gatagccgcg ttcacgttcg atctcttctg acagcagtgt 2407381 taccttctct tttaccgatt tatccggttc gttcaatgtt tcagaaggct ttttcggcac 2407441 atccttttta acagatggtt tttgattgaa tccatagaca ggcgaaggga tatttgtcgg 2407501 tttaaacggt ttcttcgccg gctctgctgc ttgatatgta tgctgctctt cttcatttct 2407561 gggacgctct ctgtaaggtg cagcacttgg acgaggcgcg gatttcggtt cgtccgatgg 2407621 tgtgcggcgc cttctcaggt catgattttt gtatccgtca ggcacgactg gaaaacggaa 2407681 tttgcctttt ggatattcat aatatatttt aggatcttcc aatcttttta attgtccttc 2407741 aggatgatgt acttcttgtt gctgcggaat ttgagcgggt tttgtctccc gttcagcatc 2407801 ctcttcgctt tcgcctaaaa acaaatcaaa aaatttatga agccaactca taatttatct 2407861 ctaactccct tatagttttc tgggacggtt tttagtatac cactgctggt cggcccagaa 2407921 aagattaagc tatcagcaga aacaaagccg ctaaacaagg gcttagcggc ttttcacatg 2407981 attcgttttt tttggcggat ttatgggagt ctaaaactga aatgcgtctc ccgcctcata 2408041 gtctccttct aacacaagga ttcctttttc agcaggggca tccggcaaat caagctcttt 2408101 cgctgagcag atcatcccgc ttgacggaac gccacgaagc tctgcatcct taatgacaag 2408161 tccgctaggc atcacagcac cgactttggc aacgacaact ttttggcctt ggtcaacgtt 2408221 aggcgcgccg cagacgatct gaagcgtttc ttctcctacg ttgactttac atacgcttaa 2408281 tttatccgca ttcggatgtt tttcttttga ttctacataa cccacaacaa acttcggaga 2408341 taaatcaacg actaatgttt cttcaacgcc gtttctgttt aaaatctcat tcacatcttg 2408401 cacgaatgtt tctgagagcg caacagggcc gttttcatca atggtcaagt aagaagacgc 2408461 attgaaaatg ttgaagcccg ttgtttcttt tgtttcgtta ttgaaaattt tgacgacgtc 2408521 gccgtgtttt tcatagccta attgttcgcg tgtcacatct tgaagagaga tcaggagcgt 2408581 gtctcccaca ccttctttat tataaaaagc gttcataagt aaaaatcctt tctaatcctt 2408641 tttcggacgg cttttcgcca ggataaacac cggttccagc tttccttcat tgtacaaaaa 2408701 tgatagggcg gtaatcggga cggtgccgcc tgcaaagaag ctcatcgaca tttgtcctag 2408761 aatatcatac cccgattcat tccggatgtc agcaagaatc aaaacgtcct gatgaggaac 2408821 agagatcgcc agctcacctt ctgcatgctg cttatactca tttaagatcg cttcgttcaa 2408881 aatccggctt gcgtcgtatc cgtcgtttgc cctgaagaaa taaaagtaat tgccggcaac 2408941 cgtatcctct ttgacaaccg tcggcaggga acggagatta aatgcggccg tctctctgat 2409001 ccgctctttt gtccagtttt ctttctcaag catgcgctgg tcaattaaac ggtaggtttt 2409061 cccgagatct agcgcgtaat aaattcttgt ctctgcggta tgatcgtcat aaatgagcgg 2409121 gatatcttcg ctggacttgt ccgggaagga agtcgagcgg atgaccggat aaatgcgagt 2409181 ttctttcccg gtcatttcct gagccttccc ttccattgcc gtcatcgctt cggagacata 2409241 gtacacgatc tcatcaatgg cttcgtcttt tttcagttcc cattttgcaa taatcggcgg 2409301 caaatcgagt gtaatccctt ttttagtcgt ttgatcctca acacggaggg tgtctttttc 2409361 tctgtcaaac agaaaggagc gattctcgtg ctgaaggcgc tgcttcagta tatctgacag 2409421 cttccttgag gtcattttca aaccgatgtc ctcctttacg ctttagcgag agagtctgtt 2409481 aaaaactgtt caatttcttc ttttgttttg cggtctttgc tcacaaaacg atttacttct 2409541 tttccttcat taaacaccac aaagcttggg attccgtaaa tttcccactc tgcacatgta 2409601 tcaatgaatt tgtcacggtc tacgtagtag taggtgaatt cagggaaatt cgcttccagt 2409661 tcaggcagga aaggctctac aaaacggcaa tccgggcacc aatcggccga aaacataaat 2409721 acagaccaat catcctttac cgctttttcc agctcttgag ttgattcaat ttttttcatt 2409781 tcatatccct ccagttgttt atgttcttac atgtttttta tcgatactcg tccatttgga 2409841 tcataccaaa ctgcttgagg caaaaccact tatatgcaac gaatgaatat gtaagattgg 2409901 ctttcccatt atcattatca tattttattt gcattatcaa gctcgtttcg tttaacatcg 2409961 tgtacatgag ggtgaaattt acagatggat atacataagg agggattttt attatggagt 2410021 ttatcgtcta tttagcagga gaaatccaca gcaattggcg cgaggaaatt aaagaaaaaa 2410081 caaaatcact gaagctcccg attacgtttg ttggcccgat ggagaatcat gaccgctcag 2410141 acaatattgg tgaagaaatt atgggcgtac agccaaatgc cgttttaaag gatgacaaag 2410201 cctctgacat caacaacttc agaaccgccg tcctgatgaa taaagcagac tttgtgatcg 2410261 ccctgtttgg cgaaaagtac aaacagtgga acacggcaat ggatgcatca tatgcgatcg 2410321 caaaaggaaa acccctgatt atcatccggc cggaatcgct ccaccatcct ttaaaagagc 2410381 tttccaataa agcgaatatt acggttgaaa ccgttaacca agccattaag gccctttcct 2410441 atctatttga aacagaataa gaaaaaagct tgtcgatccg ggcttactgc tcgttcaaca 2410501 agcttttatg aaacctacat attttcttta atcgcatcca ctgtctgctt atcgcaggct 2410561 gttacaagtt tgatgagcat ttctttagca gcagcataat catcaatatg aatgatagta 2410621 gcgtttgtat gaatatagcg ggaacatatt ccgataaccg ctgacggcac accgctgttc 2410681 gaaatatgaa ccttgcctgc gtctgttccc ccgccggata caaaatattg atatggaata 2410741 tcatgcgttt cagccatatc aagaacgaat tccctcattc cgcgatgcat gactgtcgtt 2410801 ctgtcaagaa tgcgcagcaa aaagcctttt ccaagctggc cgaattcatt tttgtctccg 2410861 ctcatatcgt ttgccgggct ggcgtcaagg gcgaaaaaca agtccggttt aatcatatga 2410921 gaagccgtct gcgcgcccct tagccctact tcttcctgaa ccgttgcacc cgcatagagt 2410981 gtattcggaa gctctttacc gtgtaattcc ttcagaagtt caatgcttaa gccgcatcca 2411041 tatctgttat cccatgcttt tgataaaatt ttcttttcat tcgccatcgt cgtaaacgga 2411101 caaacaggca cgatctgctg tcccggtcta atgccgattt tgatggcgtc ttccttatca 2411161 tccgctccaa tgtcgatcat catgtttttg atatccatcg gtcggtttcg ctgcgcatct 2411221 gtcaataaat gcggcggtat gcttgaaatc acacccggaa ccggcccgtt atctgtttga 2411281 atttcaaccc gctgcgcaag caaaacttgg ctccaccagc ctccgagcgt ctggaatctg 2411341 agcagcccgt tgtctgtaat ggatgtcacc atgaagccga cttcgtccat gtgcccggct 2411401 accataattc tcggtgcgtc ctctgcgcct cgtctgactc cgaaaacact tcccagtctg 2411461 tcctgaacga tgtcatctgc atatttggct agctcctgct tcataaaagc acgaacctga 2411521 tgctcattgc ccggcgcgcc gggaagctgc gtcagtgttt ggaaaagcgc tttcgtttct 2411581 tgattcatgt tttcccctca tttctatgta gtccttttat tttattagaa acaatgaagt 2411641 tttccaagca ctctgaccca atctgctcga tcagccgcgt attgcttaac aggatttggc 2411701 tgtttctgta taatgaaaag tacgatcaac caggaggtgc tttattttga aattgcgtca 2411761 tcttctttta ggagcaggac ttggaatttg tacggctgtc gttgtgagac aatatgtgat 2411821 gaagccttat atttcttcag aaaaagcgct tcgaattgta aaatctgctt ttaagcagcg 2411881 gggcccgatt gacggatcat ggatttacac ccagccggag ccctacaata ttaacggaga 2411941 aacggtacag gtatacaaaa ccggcattac acgatcagct ttcggagaat tagaacagta 2412001 tgaagtcatg gtggatgcga aaacgggaga aattgttgat gtcattgata caatcgcctc 2412061 ttaacaccgg acaagcaaaa aatagaagcc gctgcctatg cagcggctct tttttattat 2412121 atcgcgcgaa tcggtttgta taccggatac cacatcgcat cctgcactgc ctgtataatg 2412181 tcttcaggct cttccgtagc gacgccttcc ttcattgcgg tttttgcaac ttcaacagca 2412241 acggttgccg aaacagtgcg caaatcttca acttttggaa gcatcggcgc cccaggcacc 2412301 ccgacattga ccatacctgc gattgcccgg gcacatgctt caaacatgcc gtcggtaatt 2412361 aattttgatt ttgtaacaat cgttccaaga ccgagaccag ggaagacaag cgcgttgttt 2412421 gcctgcccga tatgatacgt aactccgtta tattcaactg gcgggaacgg gcttcctgtc 2412481 gtgatcagcg cacggccttc tgtccattcg attaaatcct ccggctttgc ttcagaaaga 2412541 gttgtcggat ttgacattgg caaaatcgcc ggccgtttca catgtgacgc catttctttt 2412601 acaatttctt cagtgaaagc gccggaaacc gtagatgtgc cgatcaggat cgtcggtttc 2412661 gcctgccgaa ccacttcaag aagatcaatg cctccgccgt ctccgttccg ctgataatcc 2412721 ttcacttcat cagccgaacg ggcatacggc ttttggaaat caagaagctg atccatatca 2412781 tctgttaaca gcccgttcct gtctatgcac cagaagcgct tgtatgattc ttcttcactc 2412841 agtccctcgc gcaccaatgc ttcccgcagc tgttcggcaa ttccgattcc tgccgttccc 2412901 gctccgaata taacaactct gtgatctctc agcggaactt tagacgcttt tgcacaggat 2412961 aagactgcgg ccaaagaaac agcgccagtt ccttggatat catcattgaa ggtacacact 2413021 ttatctttat agcgtttcaa aatgcttcgc gcgtttttcg ccccgaaatc ctcccaatgc 2413081 agcaatgcat tcggaaatgt ttctctcgcc agcgcaacgt agtcgtcaat aaattggtca 2413141 taacgttccc cgcgcactct ggaatgctgg ttgccgacat aaagcgggtc gttcaagagg 2413201 ctctcctgat ttgtccccgc atctaaaaca acagccagca ctctgctcgg atcaatgccc 2413261 gcagccgctg tataaaccgc cagcttgcca atagaaattg cgattcctcc gacgccccag 2413321 tcaccgattc ctaaaattcc ttccgcatca gttgcaacaa ttaaatcgat cgtatcgctt 2413381 tgatctttat actgtttaaa agcttctttc ataccgtccg ggtcatcgat tgacagatag 2413441 agccctcgtg gttttctgta ttcatggctg tatctctgaa ttgccgttcc gactgtcggt 2413501 gtgtagacaa tcgggagcat ttcccctaaa tggtcattta acaggcggta aaacagcgtt 2413561 tcattccgat cgtgcagcgc cgttaaatag acatttttgc tcaaatcgtc aggctgtgcg 2413621 gaatattgtt catacgctct tttcgcctga tcatcaattg ttaatacctt gggcggcaga 2413681 aagcctttta aaccaagttc ttttctttct tcctcagtaa aagcaacacc tttgttcaaa 2413741 aaaggaacag agagcacttc aaggcctctt aatgttgttt gaatgtctcc ttcgtttgtt 2413801 actctgaatt gtttcaccct gcctcttcct ttctgagcat aatagtacta ggtttgcatt 2413861 attagccgga aaacatgcag ggtaaacata aaaatatgct atcgcttcat tcgcttaact 2413921 gactttttga tgcttccgtc ctcctcccat tgaagggcgc gatactcggc atcatggtaa 2413981 aaaataaacc aagcatcttt ttctgctgcg aacgcctgcc atttctgctt ttgcgggata 2414041 gaggtcatcg gataatcatc gtaagccagc acccatagcg gattgcggtg ggcatgtgtc 2414101 ggcatcagat ctgccatatg tacggcagtt tcacccgcat cctcgcatat caggacactg 2414161 tgtccgtcgc tatggcctcc ggtgtgatgc attgtaatac cctctgtgat cgttaaggtg 2414221 tcttcaaagg ttttgacttg gccagctaca gcctcccaat tttctttcca atacgtattt 2414281 ttcgacctga tattcggatg gcgcatttcg tcccattcaa cagctgatgt ataaatcact 2414341 gcattcggaa agacagagac gagccgttca ccttcatatt ccgttaaacc gcatgcatga 2414401 tcaaaatgaa ggtgtgtcat tgcgatcaca tctatatcgg caaccgttaa tccgagtgca 2414461 gctaatgagg gtttcacatt cgactcttgt gtcacgccat agtttcgttt ttgtttatca 2414521 gtcagcttgc cgtacccaat tccggcgtca atgatgatat tgagcccatc cttttgaatc 2414581 aaaatagggt ctgttcttag ttcaatctgg tttttttcat tgactggata ttttttagac 2414641 caaagcggct ttggcacaac gccgaacatg gcgcctccgt ccatatgcgt cacgcctccg 2414701 tcaagccagg tcaacgtgat gtttccaatt ttcattgttt ccattttcac ccccccctat 2414761 catcatggta gcaaacggcc cataaaaaaa acagactcct gtcagagtct gtctttacgt 2414821 tctccattca acctcagccc gatagatcgg ctggccgagt gcagagaatt tttcttcata 2414881 ttctgtcata atattgcctt ccagattgct gttatgcaaa tcgagactga cgtatgtcag 2414941 caggaggccg tactcagaga agctcttcaa agagtactca aataaacctc ggttgtccgt 2415001 tttaaaatga atcgatccgc ctttgcccat tacttcttca tattttttga ggaagtggga 2415061 atatgtcagg cggcgttttt catgccgttt cttcggccaa ggatcagaaa agttcaagta 2415121 gacccgtttc acttcccccg gctcaaacac atccgtcagc gtgtccgcat ctatattcag 2415181 aagctttaca ttctgcgctt cgctgtcttt tactttttgg acggctgtca cgatgacgct 2415241 tttaaataac tcaataccaa tataattgat gtcgggattt tgtttggcca taccagaaat 2415301 aaattggcct tttcctgtac caacctcgat atggatcgga ttgtcgttgc caaacactgt 2415361 gttccatttc cctttataat cagcaggatt gctgatggca atatctgcgt tttcagccaa 2415421 aaagtcatca gcccaaggct tgtggcgcat tctcatatga ttgacacctc tatctattat 2415481 ttcgactaac aacataccat gaattaaaaa gacccgcaag ctcgtttttc cagtgtatct 2415541 ctcttaaggc cgagcgcata aaaaaagagg gtcccgtctg ctggaacact cctttcccat 2415601 gtataaaaac gctctgtttt gaacaattta acccgtatga tactgaaggg atgtgtaccg 2415661 ttatgggttt acattatgag catcaagttc atttattgaa ggatatattg actgaccatc 2415721 aattggactg ctgcggaaca gtcgcagagt acgagcagct tgagcgtgtg attaaatcac 2415781 tgatggcaaa caccgagctt gattcaaatt tcaaaaacgt gcttgaagat gtttaccgct 2415841 acagccaatc aggaatatcg tccaaatcca tcgactcaca catacaagag catcagaaca 2415901 gcctgtctca atgggtagag caaatggatt cgtattcctg attaatcaac aattcgtttc 2415961 atgaggatat gcagctcttc cattgcatca tgaaattcct tatcattgcc ttttgcttta 2416021 tgccaggcaa tgaaagtaat tgtttcagat aacacatacc aagccattcg caaccgaagg 2416081 ctttctgtca gctctatgcc gtacatgctc agccagctct cccaagctgg cttttcgacg 2416141 tagtggtaca gcaaaggccc gaggtccatc gccggatcag cgatcatggc gccgtcccag 2416201 tcaattaaat acagctggtt gtcttcagac aatagccagt tattatgatt gacatcacaa 2416261 tggcaaacga ctttctcacc gaaatgcact tcatgcaggt gttcttccaa atacttgatc 2416321 ccttcttgaa tcagcggcga agattgctgc acagcaaata cagcctgctt cagctgagac 2416381 aaaagagccc ccgggttcag cggttctttt ccaagtctct tcagcatgtc cagcaaggct 2416441 tttgatgtgt gtattttacg aagcaattca gcaacgggcc gtccgctcat gtctttaggc 2416501 ttcagctctc tgccggtcat ccagtgctgg gccgtaatga cgtccccatt ttccatccgt 2416561 tttgtccaaa ccagcttcgg aacaatgcct tcggcggata aaacagctaa aaaaggtgag 2416621 ctattacgtt ttaaaaaaag ctgctgcccg ttatgtttcg cataatatgc atctcctgta 2416681 gctcctccgg cggggaagat ctcccaatcg ctacctagta attgtcccaa ccagttcata 2416741 tcaatgttca acccatcatt tcttaaaata ttttagaatt aaggctaatc gtttctagtc 2416801 tatccagcga atgccttttt cgtacgaatc gtataaaaat aaaaaagaca gctattgaga 2416861 gtctcatatg ctaatcaata gccgtccttt aaattttagc gctatagcac aaacttcgtc 2416921 aagcaaaact cttaagatct gatgctaaat ataagataac cgttccgatg ccgtttactg 2416981 caaccgtttt cttgatttct gttgggtctt cctgaaatcc tgatggatca cataaaagcc 2417041 gataaggtat gtcgtttggc agcctccact cgacggagtc tggactcgcg tgatggataa 2417101 caatgatatc tttccattcg tcaacctcgt caagatcata aagcctgtat gcgataaggt 2417161 gttcttttag cgtcaagcat tcaagatggc gctggatgtc tgcagcggac ctaagacgga 2417221 atgcaggatg cgcttttctc agcgagatca gcctgcggat atagtgaaca tcttctttga 2417281 atgtttcacg gcgatcccag tcgagctggt tgatgctgtc actggattga tagctgtttt 2417341 ccactccctg cttcgtccgg aaaaattcct ggccgctgtg aataaacggc accccttggg 2417401 caagcaaaat aatcgcggct gcaagccttt gcctgcttcg ctttcggctg tcattttctt 2417461 gaggaagcgc aaagctcatt ttatcccaaa aggtgtgatt gtcgtgtgat tcgacataat 2417521 tgatggactg gcttggttcc ggaacaatcg gtgctaatgc cttccatccg gaagacccgg 2417581 caattccatg catcacagct tgtgctgatt caccgttgcc gagcgcaaac cctgttgcct 2417641 taaggtgaaa ggtgttccct tttacagcgt cacgaaacat atcattaaaa aagccgatgc 2417701 ccggcattct tggcgcgttc gccaaagcag ctttctgttc atgcggcagc ggtgtagcca 2417761 ggtcccaccc ttctccaaaa agcaggattc cgggctttgc cttagttgct ttctctttca 2417821 tataaagcac ggtgtcaata tctaaaatcc cgaggagatc aaagcggaag ccgtcaacat 2417881 tgtattcttc aagccaatag accacgcaat ccgcaatgaa ttttcttgcc atccttcttt 2417941 ctgatgcaat atcattgcca acgccggtgc cgtttgatgg catcccacat tcgtcgtgcc 2418001 ggaaaaaata accgggcact gtcttttcaa agggggaatt ctccctctta tacacatggt 2418061 taaaaacaac atccagaatg actcgcagac cgtgctgatg cagggtattg atcatttgtt 2418121 tcagctctgt ttttctcgtt tgaggatcat gaggatttga ggcatagctt ccctccgggg 2418181 caaagaaatg aagcgggtta tatccccaat tgtatgcatc aagcggcttc tcttcatcaa 2418241 ctccggcaaa atcattcacc ggcagaagct ccacatgtgt cacaccaagc tcttttacat 2418301 acgctaatcc cgaagaactg ccatttgcgg tttgtgtatc agtttccgtc agcgctaagt 2418361 attttccctt gtttatcatg ccgctgtttt catggatgga gaagtcgcga agatgcgtct 2418421 catagatgac ggcatccaca gggtgtgaga atggtttaag aggagcagtc catttcattt 2418481 gatccgggcg caagacgacg cccttctctc catttacagt cacagccttg gcatactggt 2418541 caactgtttc catccattct gaattgttgc agatgcaaaa caaatactca tatccgtgaa 2418601 ggtcacctgt gaccgtgacg gcatagacgc ctttttccaa gcgagtcatt tggaatgtgc 2418661 gcccgctttt attggggtgt gaaagcttga cagcagctga ggttgcagca ggcgcccata 2418721 ctttaaatac ggtatgatcc gcggtataaa cggcgcccag ctctccgtca taataaaatt 2418781 cgtcatcaaa cgctgccgtc cggatgaccg cgccaatttg gagatccgtt ttgtggccgc 2418841 tggatgctct gacgcaatgg atttttccaa atgtcacagg atggtcggat acgcagacgt 2418901 acttgtattt tgcttcaagg gagtattcct ccctgacagc cagaggaaaa tctgttattt 2418961 ctgtctcaag ccgaaacggc ggtgtcatga tttccttttg ttcagcagga atcagaacag 2419021 taatgatatt catgtcatcg acatacgctt cgaagctgcg gcggatgctg accatcggaa 2419081 gctctctcct ccaaacacgt ttatgttttg attcttaggg gtgaaggact agatgccaga 2419141 cgaaacgggg tagtgcccat gatttctccg tcagcatgga acgggatttt gtccttcgtg 2419201 taaaatgtaa tgtccttcgc tttaaacatc gtaacgccat ccatctttgt atgttttcca 2419261 aatgccatga gacataaaag ccaatatttt ttcaaaaacg gctggttttc aacgattacg 2419321 atatcaaatg tcttctcgcg cggatttgct aggggcgccg ccttcatgcc tcccccgtaa 2419381 aacggatggt tggatacaac ggcaaaccag acatcatgaa attcgcgcgt ctcgtcttcc 2419441 gtcgtacaag ctaatgtaaa cggcttaaag gttgccgaag cgtgcaaatg agaaagcgga 2419501 tacacaagaa atcgaaggcg gagaaaaaga aaaacccgtc tcaacggaaa ttccatcgcc 2419561 tttttattga catatgcgtc aaacccgatc ccgatatgat tcataaaata aagaatctgt 2419621 gatttatcct gaaggaaatt gacgctccct aaatgaaagg ttcttgttaa cgggcgcttt 2419681 accttcttga tttcctgtat cagatcgatt tttttaatag agaaccctcg cgaaaaatca 2419741 ttatacgcgc ccgccggcac aaagctcagc tcaatatcgt caacatcttt cagcccgttg 2419801 acaacttcat gcatggttcc gtctccgcca atgacgatca ggcgcttcag cttatattcc 2419861 tgtatcgttg aaatctgtct ggcgagcacc tcggcgtgtc ccggatgttc agttaaaaat 2419921 gaacggtgct caacctttcg tttgatcaat tctttttgaa tggacttcca aacacgcagg 2419981 ccgtttcgat gtcctgctgt cggattaata ataaaaaacc aatggctcat ctttctcacc 2420041 tgcttatgtt atgagaaaac cgctcaaatc gttctctttt actccagcca ctcctgtctg 2420101 cgataggagt cagacatgca gtaagacaat agagcctttg cagcctttac ctgatgatgt 2420161 ttgatcggag cagtgttttt cttctgccgc tcaatccatt cttccgcgct ccgcttatcc 2420221 gctatttcta agccgtatgg cggctccggg taatcgatgt acgacgttct gctcagaagc 2420281 aattttcgaa ccggaatctc agcctgtttt tcctttacga tctttgacac aaccgagtcc 2420341 gtacgaaaca ggctaagccc tggatttaac actgatgcag tctgagaggc tgttttcttg 2420401 tcccaaaaac gatttttaga ccctatgtag acactgtctt cctcagcctc taaaaaagaa 2420461 acgcaataaa tttccagagg agaaataatc acaatgctta attcaaccgc cgcctgctga 2420521 attttcagca caggcttata cataataaaa taagaatcag gcagctgctg ggtcagataa 2420581 cgcaaaatgc ggtcctgctt cacttggttt gagagttgag atatttctga aagagtagag 2420641 cttgcccatt tgagctgaaa atcatataaa tgccttttat aaaaagaagc aagcgccacc 2420701 ctgctcttcg ggagccttac atgaatatct tcttcgtcct caaaccattg gtgtctctct 2420761 tcttgtatat cggcttttat ctcttctttt cttcttttca atgaaaattt ttttcgtttc 2420821 tgcaccggtt ccggttcttc agcactggct tgcctttctt catgctggcg ctccgctgct 2420881 tctactagtg aaagccagcg ctcttttttc aaacgtacaa actggttgat ataatggtac 2420941 ggatcaagct catatctcga tatataatca tgaattttga tgatttgtgc catgtttgtt 2421001 tctccactcc gcaatgaatt aagataattg aaatttgaat atttcctcgt attttggtga 2421061 ttggttcaag tgtatttgaa agagcgaaaa tcgttcagcc atcatcgaaa cctcgccgct 2421121 ttcaaacgga acatgagctg gaaatccatc ttcgcctgtc cattttcttg ccagcgtcat 2421181 atgaggatga tacggtcttt tttccacttg aaagccggcc tgaagtacag cctgcttcgt 2421241 atgttcccgc agtctatcaa gcgttttgtt tttctttggc tccagatgta aaacgcgcgg 2421301 ctttctgcgg tcgccgaata catctatctt gccaaactta attgaaaatg gatcaatttc 2421361 tgaagcaatc tctgctagcg aaccttcaag cttctttatt tgtgtctcat ccgccgctcc 2421421 gagaaaaatt aacgtgatat gatagtcaag cgggtgcacc catttttgaa acgtcaatat 2421481 cggttcgttt ttcgcagcct ggtagatcgg atttgcaatt ccctcaggta tgggaacgcc 2421541 gatgaaataa tgaggccgta tatctggcat ccgtctgaca ctcccttctt tgacagctat 2421601 tattttatca ataaagaggc tgtgcggata gaggaacagt gtatgaaaac actctcgcac 2421661 aaacgtttat tatgttagga tattatatga cacttgtttt attcagaaag gaatgacaat 2421721 gttgaaaatc gttgcaaaca cagctgatct gataggagat acaccgctag tgagattgaa 2421781 tcggcttcag ccggaaaatg cggcacaagt ctatttaaag cttgaatttt tcaatccgag 2421841 cggcagtgtg aaagacagag ccgcttatca aatgatcata gaagctgaac aaaacggttt 2421901 actcaagccg ggatcagtta ttatagagcc gacaagcgga aataccggca tcgggctcgc 2421961 catgaatgcg gcagcacgcg gatataaagc aatcttagtt atgcctgata cgatgacgaa 2422021 ggaacggatc aacctactta aagcttacgg tgcagaggtt gtattaactc ccggagagga 2422081 aagaatgccg ggcagcatca aaaaagcgaa ggagcttgcc gaacaaattc cgaacagcta 2422141 tattccaatg cagttcgata acactgctaa tcctgatgcg caccgaaaaa caacagcgcc 2422201 tgaaatcgcc cgggcaatag aggaaatcgg aaaaccgctc ggcgcttttg tagcctcctc 2422261 tggaacgggc ggaaccatta ccggaacagg tgaggcgctc aaagagcttt ttccggatat 2422321 cacggttcat gttgttgagc cagcgggttc gcctgtatta tccggcggaa aacctggcgc 2422381 gcataaactt gtaggaacga gcccaggctt tataccgccg attttaaatg aagacgttta 2422441 tgatgaaatt atcaaaatct ctgatgaaga cgcgtatacg acgacaagac ggcttgctgc 2422501 tgaagaagga attcttgtcg gtccttcatc aggcgctgcc tgcttcgcgg caatcgaaac 2422561 agcgaaacgc ctctctcctg acaaagttgt ggtctgcatg acagctgata caggagaacg 2422621 gtacttatca actgatttat ggtcatttat ttaaaaaaag gactggcttc agcagaagcc 2422681 ggtcctttta ttttgcaagc tcgtaaatgg cctgagcata taacgctgtc gatctcagca 2422741 ggtcatcaat ttcgatatat tcatcctttt ggtgtgcgct gtcagggcgt ccggggaaca 2422801 gcgggccgaa cgcgacaccg gcttttaagg atctcgcata agtccccccg ccgattgaga 2422861 ttaaatcagc ttttttaccc agctggcctt cataaacctt ttgcagggtt ttgactaacg 2422921 gatgatctgc ggacacgtga tgcggcttgc tgtctttgaa ttctcccagc tcaaattcag 2422981 atgcgctttc gaatgtatcg cggatcactt tgctttctgc tgtcacagga tagcggatat 2423041 tgatcccgag ctcgcctcct tgcccttctt tatagcgcag tgttccgaca tttaatgtca 2423101 gctctccgct gatttcatcc tcacagtcga tgtccagttt ttttcctctt gtatcacctg 2423161 agaacttatc tgtcacaact tgcacaaacc gctttcctgc atcgtcaagc tcagtctgct 2423221 ggagaaattc gcacaataaa atgccggcat tgatcccatt gttcggttcc atcgcatggc 2423281 aggaaagacc gtacatacgc aaaatgagct gtccgttctc tattgcagct tccccttttt 2423341 ggtccgtcgt gcggagcatg tctttaaatg aagacagaat ctcttcattt ttcggccctt 2423401 caatgacagc ttccgcagcg tcgggcacca tgtttaagcg aaggcctgat tgaaacgaga 2423461 caagcactgc ctttggttca gcttgatttg ggcggtgcgg aataagtaaa gaagcatcga 2423521 tgatcccttt ttccgcatta atgatcggaa aatcggcgtc aggcgcaaag cccattgttg 2423581 gcatttcttc atgcttgaaa taatgctcta cgcatctcca atcactttct tcatctgttc 2423641 cgataatcat tctgactcgc ttggacaggg gcaaattcat gtctttcacg attttcagcg 2423701 cgtagaatgc cgccattgtc gggcctttgt catcaatggc gccccttgca taaatccgtc 2423761 cgttgcggat ttcagctgaa aatggatcac tcgtccaccc atctcccggc ggcacgacgt 2423821 caacatggca aagtacgccg ataatgtcat cgccctcccc ccattcaata tgacctgcga 2423881 agccgtcaag attttttgtt gtaaagcctt ctttttctcc aagctccagc aatgaagtca 2423941 ggctggcatt taccccttct ccaaacggtt taccgggtcc ggcggttgtt tcgtccatga 2424001 cactgttgat tctcaaaaat tcctgtgtat cacgaattaa atcctctttt tttctgatca 2424061 cttcaacttc ccagttcata atgatcccct ttccgcaaga aatgacttgc aaaaaccaaa 2424121 taaaacgaat aatattaatg gtgttttgtt aaaacgttcg taattggagg atactatgtt 2424181 tcatctaaaa gagcagcaaa catccataaa gcaagaaatc atagcagggc tgacgacctt 2424241 tttcacaatg gtctatatcg tcgtggtcaa tccggtcatt ctggctaacg ccggggttcc 2424301 tttcgaccag gttttcaccg caacgattat tgcctccatt gtcggaacgc tgtggatggc 2424361 cctggcagca aattatccga ttgctattgc gcccggcatg ggcttgaacg cttatttagc 2424421 ctttcatgtc gtaagcgcaa gcgatggcgg catcacgtac gcaacagctt tcagcgcagt 2424481 atttacagca ggggttctct tcattattct atcgttaacg cctttaagaa aacaacttat 2424541 agaagcgatt ccaaacaatt taaaatacgg gatcacaaca gggatcgggc tgtttattgc 2424601 ttttatcggt ttgcgtcaag cgggaattgt ggcagctgat gagtcaaacc tggtcactct 2424661 cggcaatctg cattcacctg gtgttatctt aacgctggtc ggccttttga tcagcgtggt 2424721 cctgatggtg ctgaatgtaa gcggcgcttt atttatcgga atggcagcta ccgctttgat 2424781 cgcctttttc accggtcagc tccatttttc aaagggattt atgtcgcttc ctcatttgcc 2424841 ggaaggattg atgatctcaa atccatttac cgcttttggc gatgtcattc atcacggcct 2424901 gtacgctgtc gtcttttctt ttctattagt caccattttt gatacgacag gcacgatgat 2424961 cggagttgcc gagcaagccg ggctgatgaa aaacaacaag ctgccgaacg tgcgaaaagc 2425021 gctgcttgct gattcaaccg cgacgacagt aggagctgtt ttcggcacaa gtccgacgac 2425081 tgcatttatc gagtcttccg ccggtgtcgc agccggggga agaacggggc ttacggcttt 2425141 gactgtcgcg gtgatgtttg cggcttcaat gtttttcagt ccgcttgtca gcgccttgtc 2425201 aggtatagcc gccatcacct cgcctgcttt gattatcgtc ggcagcctga tgatgggctc 2425261 agtttccaat atgaactgga aagagatgga cgaggcattt cctgcgtttc tcgtcattct 2425321 agccatgcct ttgacctcga gcatttctac aggaatcgcg cttggcttta tttcgtaccc 2425381 aattgtaaaa gcggcgcggg gaaaatggag agagattcat ccgctcgtca tcgttttcgc 2425441 cattctgttt ttcatccagc tgtttatttt ataaggatag accaaaaaac ccaaacgtcg 2425501 ccgtttgggt tttttatgta aacaataaag agacagcggc cgctaaaaaa caacaggcgg 2425561 caaacgcata gtgcaggatg ttgatacagc tttttctggc ccgataatat tcatcacttt 2425621 ccttatcggt gccaattaaa aaaggggcat ccatgacctt gtcaaaaata agcgtcagga 2425681 tataacggca aacccctgtg tataccagca gcgcaatcac cttcagccaa attggggaaa 2425741 caaatatgag aacagtgaaa gctgacagta gcatgtacat ctgccttgca tactcgccat 2425801 tcctcagcat aactttaaaa aacaactcct tatagcctgt gcagatcgtt cgtcttttaa 2425861 atatcctttt tgaatttcgg tataataatg gttttcttct catcctgtct tttacttttg 2425921 gcattcccgc ctcctgactc atcatcatca caagtcctgc aagggcaagc ctgctttttt 2425981 tctcttcagt cacctcagct tcaaaagccg tgaacgaggc tgtctttttc aaactgcgga 2426041 taactgagaa aaacaaaaat aaaatgccaa aaagcgcaag caagtgccgc tcagtaaaaa 2426101 caatcaggat agcagaacca gcaaaaagaa tagctctgac aagggtatcg ccaatccatc 2426161 tcgaaatgga gcgcggcttt ctgatcctgt cttgctttaa ggataaaaag aatatatgaa 2426221 ggccaaacaa ataacacaat agagcagtgc tttctgcgaa tgtgatgaga acagaatgac 2426281 tgatcaaggg aaggacaatg aaaaagagaa gcagccattt agccagcgtg gccagaaaag 2426341 aatacaaaag cgcataccgt ttgagctgat agatgatttc cttcttttgc agcaaaaaca 2426401 ctttgtccgc ttccattaaa aatgtacgaa tcgaacctgt aaacatgatc agcacacaca 2426461 cagcatacag ccatctccat tccgccactt cagaccactc ataaagaagg cctcttccgt 2426521 tcatcaaatc aatatactga tagatgacaa aagcaatcgc cggcaaaacg atatagagag 2426581 cgactgtcca gtcaatgacc gcatgcaaca ctttaaactg atacttataa tagtcaaaca 2426641 gccttcgaaa aaagagcgta cgcccgttca tagccgatca ccttgaactg ccttataaaa 2426701 acagtcaagc aatgactgcc cctctaatcc ggtcttgtcc tgaacatctt ttaacgtgcc 2426761 ttggagaaat aatgaacctt tctcaatcat ataaaaccgg tcacagattt tttccgcggt 2426821 atcgagtaca tgcgtgcaca taagaattcc ggctccacgt tctttttcag ccttaagcat 2426881 gtccacaaag cgtttcgtcg atatcggatc aaggccgata aacggttcat caatcacata 2426941 catatccggc ttagagagaa aggcctggat aagcattagt ttttgctgca tgcccttcga 2427001 aaaggtgaca ggcagctcat gtttgacatg atctagcgaa aacgtctgca gcaggctttg 2427061 ggcccgatgc gcaaattcac tctcttcaat gccgtgaagt gtgctgatca gatccaaatg 2427121 ctcccacagc gtcagttctt cgtagaagga cggatgctcc ggaatatatg caaatgaaca 2427181 gtcgttccag gcaatatgcc ctttaaaatc ttctgaaagg ccgagtatcg ccttgattgc 2427241 ggtgcttttt cctgcgccgt tagctccgat cagtccaacc agttcccctt ttctgacttc 2427301 cagaaaaaca tcggtgagca ctttttttcg gcttgtatac ccggcctgtt ctattgaagc 2427361 ttcaagcaaa tttgtcaaaa ctcactcacc tccaaaattt actacgaaat agaataaaaa 2427421 aagtttcttt aaccataata atattgagcc gaaatacata gtaatccaac aaggatggct 2427481 gcccaacgcg aaattggaaa aaattaatag gagttatccc tagattcatc actgcaatat 2427541 cgtgtataat gagggcgaat tattttaaca attacagatg tctgcctttg ttgctatttc 2427601 gtacgcagtt gatagtcgtg agttgtggtt agtcaagtcc atccgatctt atgataggga 2427661 gtggtttttt gaaaccttca acaaaccgta tgctaactcg aatcaaatca gtttacatgt 2427721 ttattcaaga aaaaggtctt gtgacaacac aggaactggt tgacgaattc ggcattacac 2427781 ctagaacgat tcaaagagac ttaaatgtgt tggcatataa tgatcttgtt catagtccaa 2427841 gccgtggcaa gtgggagaca acgagaaaga aagtaaagat tacctcataa attgaaaatt 2427901 acatagggcc gcctgagagc ggtccgatag ataacagggc gaagaaacta ctgagccttg 2427961 tttttgtgtg cttataaata aaaccccgca ttcggtatgc ggggtttttg tcatgcttgc 2428021 ggctcattta gcaaatgaag ctcttcctct gtcagctcac ggtattctcc gggtgccaga 2428081 gcgggatcta gggaaacgcg tcccatcgaa agccgcttca gataaaccac ttcattgccg 2428141 actgcctttg ccatttgctt gacctgatgg tattttcctt ctgtaattgt cagatatata 2428201 acggtattgc cactgtcgtt tgttttgatt tccgcttttg ccggctttgt tttatagccg 2428261 ccctctatgt agacacccgt ttccaaatcg gaaatgtctt cccgagaaat ctgtgatttt 2428321 aaatggactt catacgtttt tggaacatgc tttttaggag aaaggagccg atgtgcgagc 2428381 tggccgtcat ttgtgagcag caaaaagccc tctgtatctt tatcaagcct gccggctgga 2428441 aatggctcaa atctcatctc ctccggcgtc agcagatcga ccactgtttg ctgccggctg 2428501 tcctcagtcg ccgacagcac gccctgcggt ttattcatca taagataaat gaactctcga 2428561 taatcaaccg gttccccgta tacggtcacc tcctgcgtat caggatcaac gtgctccttt 2428621 acatctttgg caggtttgcc gtcgatcatc acggctccag ccttcacaac ggctttgact 2428681 tcttttctgg aaccataccc gctgttggca agcagcttat caagtctcat tcccaatctc 2428741 tcctttataa aagaaagccc gcagcatgcg agccctcagt ttcatcatat ctagttcatc 2428801 agcctgcatg tctgcctttc ctaaagaaac ctggcaaacg gcggcctaaa attttctgca 2428861 aaaatcctaa tcggtagccg caatacaggt agacagctcc gccaacagcg gccgcgatca 2428921 ccacaacaat cgcagcttgc atctggccat cctgatagga aataaagaag cctaataccc 2428981 actgcacgat tttcacggca atacccataa tggctgataa gaccagcatc aaaacagttc 2429041 gtttaacaag tatcttatac gaatagcctg catggcgctt aatcatgata aacccatata 2429101 aaagggaagc gatatatcca agcgccgtcg ctaaaatcgc tccgtcagcc tgcatcagct 2429161 tgatcagcgg aacattcagc acaagcttga tcacgacacc gatcacaagg ctgacaaccg 2429221 caaatttttg cttattgatg ccctgcagaa tagctgcgtt gactgtaaac aaagagaaca 2429281 gaattgcgac aggcgaatac caaagcaaaa tgtttgcccc cagttcagga tgaaggctct 2429341 ctgacccgta aaagaacgta tacgtcggtc ctgacaatag agagatcccg acaacagccg 2429401 gaataattaa aaacaggatc gtctgcatcg tttgattaat ctgctgattt aacagcttat 2429461 agtttccgct tgtaaacgat tcagtaatcg ttggaattaa tgtcagtcca aaagcagttg 2429521 ctagggaaac cgggatcatc acgagcttct gaacatacag ggttagaatc gcaagcatgt 2429581 cctggctgat ggcttgatga ccggcttcaa tcatcgcttt gttaaacgta tttgtatcaa 2429641 tatagttata caaagggatg gctagtccga caaaaacgta cggagcagca tagctgaaca 2429701 gctcgaaaaa cattttcttg tagcttaggt ttgctgtcgg acccgtattc ggcatcatcg 2429761 ccagcaggct gcccttccgt ttgttccaat aaatataaag cacgaccagc cctccgaagg 2429821 caccgatcag cgctgcgaag gttgcatagc ccacagcgat gacaaggccg ccgttgaaaa 2429881 ccttcaaaat caagaatgtc gcactcaata gaaagatgat gcggacaatc tgttcaacga 2429941 cttgggaaac agctgtcgga cccatcattt ggtgcccttg aaagaatccg cggacaaggc 2430001 tcataatcgg tacgaccaaa agcgctaagc tgaccatgcg gatgacataa acgacatgat 2430061 caattgtcag gccgttatta tccttgcctc ccagcgatat ttccgcaaac atcggagccg 2430121 atagatacag aatgaaaaag gctatcattc ctgtgactag cataaccgac atgcccgcct 2430181 tgagcatttt cctgcttgtc tcataatccc cttttgaatt atatttggaa acaaatttag 2430241 aaacagcggc cggaaagccc atcgtagcaa tattcaaaaa taaagtgtat tggttgtatc 2430301 cgtattgaaa taatgcaccg cctgtcgccc cgaccataat gctgaaggga attaaataga 2430361 ccatccccag aatccgcgat atatatgtac cgagcgttaa tacaaacgtg cctcttaaca 2430421 gtttgcttga catgtttctt catcaccatt ttctacgaag attcaacttt tctattttac 2430481 cacaactggg catttagacg gtaataaata caaaagcaat cctgtgaaca ttcatgtccg 2430541 cggcaaaaga cgtttaagga gcggctttct ttcgctataa tagtactgcg gacgggtgtc 2430601 cgcacacgaa atgaaaagaa agttgatgat aaagatgaaa caatatgacg taatcgtaat 2430661 cggcggaggc ccttcaggct tgatggctgc gattgcagca ggagaacagg gcgctggcgt 2430721 gttgctgata gataaaggaa ataaattagg acggaaactc gcgatttccg ggggcggccg 2430781 ctgcaatgtg acgaaccgcc ttcctgtgga agaaattatc aagcacatcc ccggcaacgg 2430841 gcgtttttta tacagcgcgt tttctgaatt taataatgag gacattatca agttttttga 2430901 aaacctcggc attcaattga aggaagagga tcacggccgg atgtttcctg tgaccgacaa 2430961 agcccaaagt gtcgttgacg cgctgttaaa caggctaaag cagctccgcg taacaatcag 2431021 aacgaacgag aaaattaaat ctgttttata tgaagatgga caggcagcag ggattgtgac 2431081 gaataatggc gaaatgatcc atagccaggc agtcattatt gctgtcggcg gtaaaagcgt 2431141 gcctcatacc ggaagcacgg gagacggcta tgaatgggct gaagccgcgg gccataccat 2431201 aacagagctg tttccgacag aggttcccgt cacttctggc gaaccgttca ttaagcaaaa 2431261 aacacttcag ggcttatcac taagagatgt agccgtcagt gtgttaaata aaaaaggcaa 2431321 accgattatc acacataaaa tggacatgct gtttacccat ttcggcctct caggacctgc 2431381 cattctcaga tgcagccaat ttgtcgtaaa agagctgaaa aaacagcctc aagtgccgat 2431441 cagaatcgac ttgtatccgg atatcaatga agaaacgctt ttccaaaaga tgtataaaga 2431501 actgaaggaa gcaccgaaaa aaaccattaa aaacgtgctg aagccttgga tgcaggagcg 2431561 ctatctccta ttcctgctcg aaaaaaacgg catctctccg aacgtatcgt tttctgagct 2431621 gccgaaggat cctttcagac aatttgtaag ggactgcaag cagtttactg tcctcgcaaa 2431681 tggcacactg tcgcttgata aggcatttgt cacgggaggc ggggtatctg taaaagaaat 2431741 tgacccgaaa aagatggctt ctaaaaaaat ggaggggctt tatttttgcg gtgaaattct 2431801 ggatatccac ggctacacag gcggatacaa tattacctcc gcccttgtca caggcaggct 2431861 tgcagggcta aatgccgggc aatacgcccg ttcttaatca ttactcttta aatctcttgc 2431921 cgccaaactc acatttgaac attccccgca ttcatgttag ggtgagactt gttttgtttc 2431981 acctgattgc ggggtaattt taagagagga atgagctgcc atcgtacgac catactaagc 2432041 ctgcgagcaa gatataggcg tacacaaaaa attagagggt gagaaatgtt gaaacatata 2432101 tctagtgtat tttggattgt gattgcaatc acagctgcag ctgtattatg gggtgttatt 2432161 tctcctgaca gcctgcaaaa tgtgtctcaa tcggcacaag catttattac cgattcattt 2432221 ggttggtatt atcttttagt tgtctctttg tttgtcgggt tttgtctctt tttgattttc 2432281 agcccgatcg gaaaaatcaa actcggaaag cctgatgaaa aaccggaatt cgggttatta 2432341 tcatggtttg ccatgctgtt cagcgcaggc atgggaatcg gcttagtatt ctacggtgcg 2432401 gctgaaccga tcagccatta cgcaattagc tctccatcag gtgaaacaga aaccccccaa 2432461 gccttcagag atgcactccg ctatacgttt ttccactggg gtttgcacgc ttgggccatt 2432521 tatgccattg tggcattatg cattgcctat ttccaattcc gcaaaggcgc acccgggtta 2432581 atcagcagca cactgtcacc gattctcggg gataaagtaa acggaccgat cggaaaggcc 2432641 attgactgta ttgcagtttt cgccactgtt gtcggggtgt caacaagtct tggtcttggc 2432701 gcaacccaaa ttaacggcgg tttgaattac ctgttcggca ttccgaatgc gtttatcgtc 2432761 caattggttt taatcattat tgtgacagtg ctctttttac tttctgcgtg gagcggactc 2432821 ggaaaaggaa ttaagtattt aagcaacaca aacatggtat tggccggatt gttaatgttg 2432881 tttatgctcg ttgtcgggcc tacagtgctg ataatgaact catttacaga ttctatcgga 2432941 caatacattc aaaatatcgt tcaaatgagc ttcagactga caccgaacga tcctgaaaaa 2433001 cgcgaatgga ttaacagctg gacgattttc tattgggcat ggtggatttc ctggtctcca 2433061 tttgtcggca ttttcatcgc ccgtgtatcc agaggccgga cgatccgcga atttttaatc 2433121 ggcgtcttgg tgacaccttg tattttgaca tttctatggt tctccatttt cggcgtatca 2433181 gccatggatc tccagcaaaa aggcgcgttc aatgtagcaa agctgtccac tgaaacgatg 2433241 ctgttcggaa cacttgatca ctatccgctg acaatggtga catcgatcct tgcattgatt 2433301 ctgatcgcag tattctttat cacgtcagct gattcagcta cattcgtgct gggcatgcag 2433361 acgtcgtacg gttctttaaa tccggcgaat tctgtgaaac tcagctgggg tatcattcag 2433421 tccgccatgg cggctgtgct cctatattcc ggagggcttg ccgctttgca gaacacagcg 2433481 attctggcag cgctgccgtt ttctatcgtt atcctgctga tgattgcctc tctctatcaa 2433541 tcgctctcaa aagaaagaag agagatcaaa aaagcggaga aactcgataa accaagaagt 2433601 ccaagagtga aaaaagcata ttaacaaaaa agatctttcc gcgcctgcgg aaagatcttt 2433661 ttatttgcga tataaaataa gggcggaaaa acagtaaagc tgctcgccgt ctgggtcgca 2433721 cgccgccgaa accgtatatt tgatatctat cagctgctcc tccgatatcc cttttaaaaa 2433781 tgaattgatt tccgtttgta agtctttttc atgctcttca tcaaataccg ctaccttcag 2433841 cattttatcc gctctccttt ctctatcaat ctattccgtt tggaacagcg ttatgataga 2433901 gaaatgatga ttatctcgtt tccggataaa aagctttccg tatatgggat ttcctctgtg 2433961 gctcgccgcc gtgctgctcc actttcagca gcacggcata aacaatgcgc atatggcagt 2434021 agctgataag gctgacgctg aaaaaaggga caatgcccgg caggtacgca agcaagaaaa 2434081 agagagcaac agtcagcgca agcatagtaa gcgtatattg caaatacgcc acactgagca 2434141 agagcgaaaa tttcacatac agacgttttt tccagtcaaa atggacaagc agcggaaaca 2434201 cataaaaaag catggatacg aacaaaaagc caaatatcat aatggcgaag cgcaggatgt 2434261 gcagaaggaa atgacttgga taaattaagg ccaaatcaat ataaatgatc actccgatga 2434321 gcgccagtac agcgccgagc agatttgaac gaaaaaattc acccttgtat tcctgccaaa 2434381 acgttttgag caccggaacg ttgtcctgcc cctggatcca cttccgcatg acagcgaata 2434441 aagccgcggt cgcgggcatg atgccaaaca cgccgagacc gagcaacgta aaaaacagcc 2434501 acagcaagtt tgtatacgca aatctcataa tccattcgca aaaacgcagc atccgtccca 2434561 gtgagccatc atgttccatg gcgccccctc cttttttgca ttatacattc tgcatctgaa 2434621 aaagctcttt catgccgatc ggcttctttt cggcaaccga gcgccacatt ccctcaccaa 2434681 ccgcgatgga gtaggctcca gcttcagccc cggctaaaat atcatagcgg cgcagcgggt 2434741 ctttccctaa aaaaagatcc tcaagcaaaa gcggatcacc tccgccatgc cccccttcat 2434801 ttttgaccac ttgtatcgtc tgctttgatt caaaaagcgg atagtattcg attgtctgct 2434861 caggaaaagc aaacggaatt ctggaaggtt cgtgaaattc atttgattca atacgtcctt 2434921 ttgtgccgtt gatcgtcagc cggtagcctt catacggggc cgaaaaaata atcgagtagc 2434981 ttaacagtgc gccgccatca tatttgactg ccgccacgta cgtatcctcg atgtcaattt 2435041 cctcgtcaaa aatacacgcg tcaggcctgt atgcagtata taagctggac tggtctcctg 2435101 cttcaagatg atcatccttt atagaagctt tagaggaacg gggatgccac cttgaatagt 2435161 agtggcattt ttctttaaca cggcacgtcc cgcaaaaacg cccgtcttct tccggcaagg 2435221 ggttccactc actgtccggc ccatagtaat tcaaggcgcc ataagcaaat acctcttccg 2435281 gattttgccc gagccaccaa ttgacgagat cgaagtgatg tgttgattta tggacagaaa 2435341 gaccgccgga aaactgtctc gacctgttcc agcgtttaaa atagctggcg ccatgatacg 2435401 tatcaatata ccaatttaaa tcaacagaag tgaccctgcc tatttttccg tccagaatca 2435461 tttcttttat tttccgatga aacgggctgt agcgatagtt aaacgcgacg gtgacttttc 2435521 cttcgctttt ggcctccgct tcaagcaccc gattcgcatc ctgcactgtt gtcaccattg 2435581 gtttttcagt aatcacatct gtattccact gaaggctttt tacaatatat gcgacatgcg 2435641 tatcgtccct gcctgccaca atgacgatat caggctttga gacgcgcatc atctcgtcaa 2435701 aagcatcttc gctaaactca ggcacgtggg ccagctcggg aaatttcttc ttgcaaacgg 2435761 caaaacgttt cggatcggca tccagcaatc ccgtaatctc ataatgagtt gaaaaccgct 2435821 ccatcagtgg tttgataaac atactgaatg ctctgctgct caatccgcaa aagacgatgt 2435881 tcttcaatat cctcacctct atcgggcttc agttagttga gaaatcagct gcagcgcttc 2435941 ctctgttttt tcagcataca cagggataaa cgccgccata tcgcgattca attgaaaaga 2436001 atagccgttc agctgttttt tccctttttc gatctgaacg gcatagatcg ttttttctcc 2436061 tgttttttta ttaacagttg tataaggaga tgttttttca ggaggcaatc cgtttaacgg 2436121 ctgaaaattt tccggatcat cgtaagcttg aaacatgtct tcaggcacga tgaaaacatc 2436181 tccctcatgg gcggtaattt cagtcagcag tttttcctga aaagctggaa agatatcgac 2436241 cttcccggca ttctgctcgg cggccttttt tattttttcc tgtacgccag cctgcatatc 2436301 agaaaagaga atgacatgca ttccgtccgg cctgcttgag catgatgcca aaaagagcac 2436361 tgagacgatc acacacaaag ccgtacgtat cctttttgtc atttccccgc tgacctaaaa 2436421 agaggctcca gctctgtcat agctaaaata aacgcgccgg ctccgtgcag atcgtttgtg 2436481 cttctttcgc ggctgacata atagtcatag aaaccggctg acgttccgac acatatgtct 2436541 ttgacgagaa acgctccgtc ttctgatgtt tcggttttat gctgaatcaa gccttgatac 2436601 gcttttagca gtgttgtttc gtaagctctg tctagatagc ctttattgat tccttttgcg 2436661 attgcgtaca tgtacagaca ggatcctgag ctttccagcc agttatcaga cctgtctccc 2436721 ttatcaacga tctggtacca taaccccgtc tctttgtctt gatagcgaca gatgctttta 2436781 atcatgtcct gcagcgtgtt tttccacaca tgacggttcg gatgcttctt cggcagctct 2436841 tcaatcatgt cagcaagaga catgacgtac cagccgatgg aacgtgccca aaattccggt 2436901 gaacagcctg tctcttcatt ggcccaaggc atttttttcg cttcatccca ggcgtgataa 2436961 aaaagtccgg tttttgcatc cttcgtatgc tttctcatca atgactcctg aagcacaacc 2437021 tgatcaaaca gctccgtctc ctgcttcaga ttggcatatt tcagtgcaaa cggccccccc 2437081 atgtataagc cgtcaagcca catttggtaa ggataaccgt ctttgtgcca aaaaccgccc 2437141 tcagacgtcc ggttcagtgt tccatataag ctgcgcagcc tttttgccgc tttgacatac 2437201 cgttcatcct tcgtctgctc gtataatgga aaaagaatga gacctgcttg aatggcgtcc 2437261 agttcatctc ttctaaataa tagattgcca ttatcatcga ttaagagatc tgcataagcc 2437321 ttcgcatact caaaataccg cttttccccg gttgcttccc acagccgcaa tacaccgcat 2437381 aagaaaacac cctgatggta gtgccagcgg tttgcaggtg gcagctcctc gactgtgtac 2437441 gtgttcataa tggtgtttgc caatgcctcc gcgtacgtaa gaggcgattt tacagcgatt 2437501 gattgatcca ttgatcccat ccctttccta ataaattcct tcctcgccaa atttcttcgc 2437561 caaacgattc gctagcatga ccaaaatcag cccgaccgcc gctttaaata cgccgactgc 2437621 tgtactgtag ctgaattggc cctgtttcag ccctgcagta taaacatacg tatcaaaaat 2437681 ttccgccact tccctgttag tcgcatttaa cagcaaatac acatgctcga agccaagctc 2437741 cagcgtgtct ccgattttca aaatcagcaa aacgacgata acgcttttaa tggcgggcag 2437801 cgtaatatgc cacatttgcc gcagccgtcc cgctccgtcc attttcgccg cttcatacag 2437861 ctgggggtca accgctgtaa tggccgccag ataaatgatc gtcgaccagc ccgcttccct 2437921 ccagataacc tgcagaatat acaggggccg gaaccattct tcgttcagca gaaaattgat 2437981 tttttcaccg ccaaaaaaca caatcagttc attaatcaag cctccgtcta ccgttaaaag 2438041 cacaaacgaa agcgatacaa caatgaccca agacataaaa tgcgggatat aaatcagcgt 2438101 ctgaacaaat tttttaaaga gagcaatccg cacttcgttc aatagaagcg ccagcagtat 2438161 cggcaccggg aaaaatatgg ccaggttcaa agcaaataac acgagcgtgt tttttaacaa 2438221 gagaaaaaat gtaggctcag taaacagcct gataaaatgc ttcagcccca cccactcact 2438281 gcccaaaatg ccgaggaacg gctgataatc ctgaaacgca atcacaattc cccacatcgg 2438341 gacatactta aaaagcaaaa aataaataca ccccggcaaa atcatcaagt acaaatattt 2438401 ttgttgaatc agcttgatta gtaagcgctt tcttttttct tttttaaaaa tgactgcatc 2438461 aacagccggc gcttgcgctt ctgctgtttt cattttttcc tagcctcctt tcacggattc 2438521 ttgcattcac tgtagcgcag caggcaaaag tccgtctaca atcatatgat cacatcctgt 2438581 tttatccctt tataatcaag ggttcagccg gtccacctga aaaaaagaca ccgatattag 2438641 aaaatgatta ttgacaatat ctatcaatct ttggattaat tgtattaagg tgaagtggat 2438701 gttatgaaat ggggggtttt atgaaaagaa gccaatacaa gttttactac aaactgatca 2438761 cgtttttctg cctgctcagc accattccgg ttattttggt cggattattt tcgtacgagc 2438821 actctcagaa aacggctatt tccaacgttt cggaggaaaa attcgacaca ctccagcaga 2438881 cccagcaaag catcgagcat atattgaaaa ccgtcgatca ctctttaacc cactatgtga 2438941 gttcgccgcc tctccttcgc acattgtccg agcctttgca ctcagaccaa tttcaaatct 2439001 ataaccaagt gaaccaagag ctcaattatc tgcaaagctt tgataccgat ctgtccaaca 2439061 tgacgttagt cagttatacg aaaaaatggt acatgaacaa ttccggtttg taccgtttga 2439121 atacagacac tcttcatgaa gcagcctcag cgtacacgaa acaaaaagcg agccgctcct 2439181 attggacgct tgaggaaaac aatcatttga tttcaaccaa agaaggcaca gcagaaaact 2439241 gccgctacaa tatcaattta attaagcagc ttcctttgaa cagcacaaat acaaagggat 2439301 tggccgccgc aagcatcccg agctgttcgc ttgtcaaaaa tatgcccggc tattcaaacg 2439361 ccaacaacct gtttatcatc gatgaaaaag gcctcatcat ccttcataac aatatgtctg 2439421 acgttggtga atctcttcat aacgacggct ttgtccaaaa agtgctggcg caaacggcca 2439481 atagcggaca gtttgaaaca gtgattgacc ggattcatta taaagtcacc tatcaaaaat 2439541 ctgactataa tgcatggact tatttttctc tcgtttccct gcctgagtta aaaaaagaag 2439601 ccaaatcaat cggctggatc acttttgcag tatgcctcat tttgttaacg ctttcattgc 2439661 tgttctcttg gcttggctcc cgccattttt acaagccgat cagggtgctt tacgaatcat 2439721 tcgcaagaca tggagccata caagagaaac aacagcctcc tcaaaatgaa tttgagttaa 2439781 ttgaacagag ctttaagcag ctgaaggaca gaaatgacga ccttgaagaa acgatgaagc 2439841 agcaggccac tcatctgcag caatatttta tggtcaggct tatgcttgga aaactgacgg 2439901 atgaggaggt tgataaccgt tttgaaagcc tcggcttaaa gcaaaattgg cggcaccttg 2439961 ccctgcttgt gctccaaatt gacacactga atcatacgcc ttatgagaaa aaagatatgg 2440021 atctgctttt gtttgccgtc aacagcctga ttgagcgcaa catcccgacg gacaaacatc 2440081 ttgcccccgc cgtagttgac aaacagcagg cgacgatttt gatcaatcaa agcgggacaa 2440141 aggaagaatt catggctgag ctgaatgaga ctgcaaggat gattcaggaa aaagcggaag 2440201 ctgagctgca gctgtctgtc agcatcggca tcagccagcc gtttgatgtg ctgacaaaag 2440261 cgaaaacagc ctatgcggaa ggctcagaag cgttgaaata tcggctgaaa gcggaaaaca 2440321 agtcgatcat cttttacgaa gaccttgacc agaaaaaaac cttcaaaacc cattttccaa 2440381 agcagcttca gcatgagctg ttcgatgctg tcaaagcagg agacaaggag aaagcggata 2440441 aatgcctgca cgcgatttta caagccattt tcacccagaa caccaacccg tatcaatttc 2440501 aaatcgccat cgcccgtttt ttgaaccatg tgattgagct gatgcatgtg cttgggatcg 2440561 aattgtttga gcttgaagaa aacaaaatgc tgtatgacca aatttttgag ctgaaaacgt 2440621 tcgaggatac cgaaaactgg ctaaagaatg agtttattga tccgatgaca gacaaagtga 2440681 acgcccgcgc ggatgcccag tacaaaaata tttccgacaa catcattcat atcatccatc 2440741 atgagtttga atccgaattg acactggacg aaatcgcacg caggctgcat tacaacccaa 2440801 attatttaag cagtattttc aaaaaagaaa tgggaatttc attcagcgag tatgtctcaa 2440861 gctaccgaca ccatatggcg aaaagctggc ttgccgaaac cgacatggcg gtcaaggaca 2440921 ttgccgaaaa gctgaaatat aaaaactccc aaaacttcat cagatcattt aagaagctgg 2440981 aagggattac accgggaaac taccgccagc aaaaaagaag catgtaaaaa acccaaaacc 2441041 gcttgcgcgt tttgggtttt tccaatgtta ttttgcttgt ttaaacgctt cttcgtattc 2441101 ctgaataatt tgttttcctc cgcttgactc ccatttttcc acttctttat cgaactggct 2441161 ttctgtgatg tctccaatca tatatttgta ggtcgcgtca tcaatgattt tcttcagttc 2441221 gtcaccccgt tccgactccg atgcggaata caggctttca gccgggtttg agacgataat 2441281 cttttcattg tcctcggtca gctcctcgta cgccgtccga agcggatctc cagtgttttt 2441341 taagtaggct ttatcaatgg caattaaagc ggacagcggc tgaatatcag tctgccagtc 2441401 ttttacctgg ctttctttgc gtgtaaacgt tttgtcctca cctttgttgt aatgaacgcc 2441461 gtcaatgcca taagtcatca ggctatagac atcttcttcg gcaattcggt caaaaaacgc 2441521 caagatccgt ttaagctcag cttccgtttt cacactcgtt ttcgggaaag caaacacgcc 2441581 gttatggcct cctgatgccc atacccgctc tttcccatct gggcctttta tgcggttgat 2441641 gatctcgagc ttcatcgatt tatcagaggc atggtcgcgc agattgaccg catctaccat 2441701 attgccaata taaattccgg cttttccttg agaaaacagc tcttgctgct gggttttgct 2441761 tgtgacggga aaatccttat tcatataccc gttatcacgc agctttttca tatagttcat 2441821 cgtgtctttg tattcctgtg tcatgaaatc aggcgtgaat ttgccgcccg attccttcca 2441881 atctgtcggc atgccttcat acgagccaat cgttttaaac gcgccgtaaa tcaagtcatt 2441941 acggtctgcc agcccgaatg tatcatcttt cccatccttg tccgggtcgt cctccgtaaa 2442001 tgctttggcc acttcataaa gctcatccaa cgttttcggg gttttcaaat ttaaattgtc 2442061 cagccagtcc ttccgaatga cgatcccctg tctggaaagc gggcgctctc tgtatatccc 2442121 gtagagcttg ccgtcaattg tcacattttt attaatgagt ttgttcattt tgtttaagtt 2442181 gggataatcc ttgatataat cgccgatttc ccaaaacatt cctgaccgaa aggcattcat 2442241 gactgacgaa tttttaatat cctggatggt cacgatttgc ggaagattgc cggctgcaag 2442301 cgctgcattc agcctgtctt ctttcaccgc gtctggaacc caggtgatgt cgagttctgt 2442361 atttgtcagc ttttcaattt ctttaatcgc cctgtctttc ggcggctgct ggtgatacaa 2442421 aatcgccatc caagacagct ttacctttga atctgggcca gctttgcctt cagccgaaga 2442481 ctgatcagtt cctttacagc ccgccagcac tccgccgagt gccagtacaa gcacaatcaa 2442541 aagcaccctc catttgtttc ccatcgtacc cctccgtttc atatttcttt atcctttgac 2442601 agatcccagc aaagctcctt ttgcaaaatg cttttgtata aacggataga caagcagaac 2442661 agggatggtc gccaccacta tgaccgccat tttaatggtt tgctcaggcg gcgggctgcc 2442721 cgaccccatt tcagacatat ccccctgcat accgcttgat acaatgacga tttggcgcag 2442781 aagcacctga attggccatt ttgctgaatc atttaagtac aagatcgctg tcatatacgt 2442841 gttccaatac gtgaccgcat aaaatagtga aatcgttgcg atcgcaggaa gagacagcgg 2442901 cagcacaatt ttaaagaata tgcccagatc attgcacccg tcaattttcg cggactcttc 2442961 caggcttgac gggatatttt gaaagaagtt tttcagaatg atcaggttaa aggcattaat 2443021 ggctgtcggc aaaataagcg cccagtaaga atcgagcaat ccaagcgatt tgaccacaag 2443081 gaaagtcgga atcatgccgc cgctaaacag catcgtaaat acgacgagaa acatgagcgg 2443141 ctgccggccg attaaatcac ggcgggataa cccgtaagcc atcagtgacg aaagaaacat 2443201 gctgaccgca gtgcctatca ctgtcacaaa cacagaaaca agcaaactct tataaataat 2443261 atctgttgaa aaaatgtagc gataagcatc tagcgaaaaa gtggtcggta ttaaaataaa 2443321 ttttttcgac acgacttctt ctactgtggc aaaggatgct gcgataacat gaatgaacgg 2443381 aagtacgcat attaaagcga acatcagcaa gaaaccataa atcaacatat caaacagacg 2443441 gtttttcagt gaatgtgcga tagctcccac ctccctttgt aagcgttatc atatttttgg 2443501 aaaccgagct cagcatgtga cgatatcgtg tctaaaatgt agcaaatctg tgattgccat 2443561 gtctataatc atttgaacag tgtccccggc cgggcggggg ctgccgcgaa ttgagaccga 2443621 taacaaaaga aaaagagcat aatcttagaa aatgattatg ctccgttctc ctcctcgttc 2443681 agaagttcag ccgtattgat ttgtggcgaa aacccaagtt cattcacggc agattcaatg 2443741 gaccatggcc ggcccggatt atcagagacg gcgtaataag tgccataccg gatgttggtc 2443801 tcaatggcgg ctttgaaaat cgacagcaga tcggggtgag aaagcagtgt ctttttcgtc 2443861 cgttcttttt catgcagcgt atccatttca tctgtcacga ctgttccgat tcgaaggttg 2443921 attactgata gcttattttc caaataaaac aaatggccga tctgttcaga ggtcagcttt 2443981 aatacaccgt acaagttttt tgacagcgga taatcgcttg ttgtgatttc ccgtcctaag 2444041 agcgagcgcc cgtctttttc atatacatct gtgacatgat tgctgctggc gaacacgagc 2444101 ttttgaatgc cgagctccgc tgccgcacgg cacagataat agcttgccct atagaaaaca 2444161 tccgtcattt tttcaaactc agcgatgtcc ataatatcgt atttgatttt cacagcgagt 2444221 aaattcaaga tggcatcggt atcttttgga atcttcttca acagctcctc ataatttgcc 2444281 gcgtcagcct gaatggaaga ggctttgcca tcgaaatgat ctttatcaag cacagtcact 2444341 tcatagtctg aaataagccc ttcagcaagc agtctcccaa tcacaccatt tccgccggcg 2444401 atcagcactt ttttcacgat gttcactccc cttttttata gattgcccat tttcggcggg 2444461 gctgacactt ttttggcact cacattctta ggcttattca aaagtcaccg gcagctcctc 2444521 aagcgcccga aatccaaaaa gcggccgata ccgccattca aaatccgcaa gattaaggct 2444581 gggcattcgc tgcagaagag tgttaatcgc aatttgcgct tctaatcgtg ccagcgagga 2444641 ccctaagcaa acatgatggc catgcccgaa tgaaagatgc ggattaggac ttctcgtaat 2444701 atcgaagaca tcggggttcg tgaatatgct agggtctcga ttagccgctc ctaacaaaag 2444761 atagacttgt tctccttgac ggatcgtcac cccgcagatg tcaatatcct ctgacgcaac 2444821 tctggctgtc atttgcgtgg ggctttcata gcgtaaacat tcctcgactg cggtaccaat 2444881 aagatctgga ttttctctca gtttcaaaag ctgttctgga tgctgcagca gacaaaggac 2444941 tgaattgctg atgagattga ccgttgtctc atgtccggcg atcgccagca atatgcacgt 2445001 agatgccgcc tcctcttccg tcagcttatc cttttctctc cccttcaaga gcatgctgat 2445061 catatcctgt tgagggtggc gttttctctt ttgaatcagc tctttgaaat atgccatagc 2445121 ctgcacagcc ataatattgc cctctgttaa tgcctttctt gagcgggtaa aatcaatcgt 2445181 ttgaatgaga ctcgcagccc actcctttaa ttgctcccta tcttcctccg gtacacctat 2445241 aatgttagct atgacaaaac ttgctaaagg aaaagcaaag tccgaaatga cctccatctt 2445301 ttttttacct tgcacttgat caagcaaatg atggacagtt tcaatgatat acggctgata 2445361 actctctgtc gttctcggcg taaacgctcc gctggcaagc gtccgcaatc gtctatgatc 2445421 aggctggttc tgaaacagca tcatttgatt ttgcacatgt gaaaggtcct gatatttggt 2445481 tgagctctca ggcagcgggg tgcggacttt gaatctcgca tctttcaaaa tagcagccgt 2445541 ttcttcatat cctgtgacat accagcccgg gtattttaag aaactccctt tatagatagg 2445601 atgaacagct cgcaatgtgt cgtaaaaaga atatgggttt ttcaaaaact cagaagatgc 2445661 agttgacgat gcaattgtca cgtgattttc tcctttctgt tcaaaaataa aaacaatcga 2445721 catcataccg attgctttta ttgattcttt cagcttttcg cacttaaact agccttcatt 2445781 tcttcgactg attcaacttc aaagcctaaa tcactcagca ttttatgatc ctccgtctcc 2445841 tcttgcccgg cagttgttaa gtagtctccg acaaaaatgg agtttgcggc gtaaagccct 2445901 aatggctgca atgtgcggag attgacctct cttcctccgg aaatgcgaat ttcttttgat 2445961 ggattgataa aacggaacag cgccagcact tttaaacaat acagcgggtt taattcgttg 2446021 acgccttcta acggcgtgcc atcaattgca tgcaaaaaat tcacaggaat ggaatccgcg 2446081 tcaagagcct tcaagctttt ggcgatgtca atgacatcct gtttcgtctc cttcatcccg 2446141 ataatggcgc ctgaacacgg agacagcccc gattcttttg cgatttcaac cgtattgact 2446201 ctgtcatcgt atgtatgtga ggttgtgatg tttgaatggt ttctctgtga cgtattcaaa 2446261 ttatgattat agcggtctac tcctgcatct ttgagccgct tcgcctgctc tggcttcaac 2446321 agtccaagac atgcacaaat cttcagtcca tacgtctctt taatttcctg aaccgcatct 2446381 acgacctgat ccacttctct gttagacgga cctctgccgc ttgccacgat acaatatgtg 2446441 ccgatattca gatcgtgcgc ccgcttcgcg ccttcaagca gcgtttcctt attcaccatc 2446501 cggtaagact caatcggcgc tttcgaaatc gcagactgtg aacaatagcc gcagttttcc 2446561 gggcagagcc cggatttcgc attcataatc atattgagct ttactttttt tccgtaaaag 2446621 tgttttctga tgtgaaaagc cccgtgcatt aatagcaaaa tatcttcatc aggacaatgt 2446681 aatattgaaa gcgcctcttc gtcagtcact tctgctccag ccagcacccg gtctgcgagt 2446741 tccatccatt gattcattct cataccccca cttgattcat cagtaatgat agattgatat 2446801 ggtcttttac catatgtaga accgtttctt tcgtcacgtt ggcaagcttt ggcgtaaccc 2446861 ctaaaatcgg cacaccgcat aagcgctcaa tcatctcagg attggttttt tcatcttcat 2446921 caggagagtc actgattcca ttgatgataa ttccggcgat tggaagcccc atgctttctg 2446981 catatttgac agttaaaaag gtatgattaa tggttccaag gcgaggacgc gccacaataa 2447041 tcatgggaag ctgcaacgct tttatgacat gactgaccaa atagtcctct cccaatggca 2447101 cagaaatacc gcctgcacct tctacgatga agcattcatg tttttctcta atccgccccc 2447161 aatggcttaa aacctcttcc atggtgacag tctttccctc aagtttccct gcaacgtatg 2447221 gtgcaagcgg cgccttgaag gcaaaaggcg taatgtcttc atgagaaaga ctggtctgcg 2447281 acatatcttt cagcaaactt gtatcactat ctggatgatg gcgcgatatc ccgcttaaaa 2447341 atggtttata caccccgaca tgtctattat tgtctttcaa taaggcagca agaccgctgg 2447401 atataaccgt tttccctact tctgtatcag ttcccgtcac aaaaaaaccc ctcaaatgat 2447461 gtgcagctcc tttccgattg aatgaaatgt ttgcagcaaa tgatcaatat cacccatact 2447521 gtggtcagac gtgattgtaa ttcgaatccg gctttcaccc ggcgcaacgg ttggcggccg 2447581 aatggcagga gcataaattc ccttgccctg cagtttttca gcaaatagga ccgttttatg 2447641 ggcatcgcca atgactacag gaataatcgg tgtgtgatct cctttcacca cataacccat 2447701 attcttcaga ctggttctga tcatgctgat ataagaaaat aaaagctgtc gtttttccct 2447761 gctggcttca atgatgttga aagcctcgtg agcagccgca cagctggctg gcggaatagc 2447821 ggtttgaaag ataaatgttc tggcatggtt cagcaaaaag tcgatgaaga ccgctgatcc 2447881 tgccgcaaaa cctccttccg cgccaacagc tttgcttaag gtgccgataa caatgtcggg 2447941 acaaacacca aagtattcac tcgttccttg tcccgaatcg cccaaaactc ctgttgcgtg 2448001 ggcatcatca acgaccacga aggcatgata gcgtttcgca agtgagatga tctgatcaag 2448061 aggggcgatt gtgccatcca tgctgaatac tccgtctgtt acgataaaac ggcgctgata 2448121 acgctgtgtt tcattcagct tgttttcaag atcattcata tcaatatgcc gataaacaac 2448181 tgtatcagcc ttagaaagtc ggcagccgtc gatcatactt gcatgattga gctggtcact 2448241 taaaatgaca tcttcctttt ctggcaagga tgaaaggaca ccgacattgg ccaagtaacc 2448301 gctcgaaaac agcagggccg cttctgtcag tttaaagctg gcaatcttct tttctagctt 2448361 ttcatgccag accgaattgc ctgtcgttaa acgtgaaccg ctgcttcctg tcccaaattg 2448421 ctgcaatgct gtttgggctg catcgatcaa acgtctatcg cttgcgagcc ctaaataatt 2448481 gtttgaggac cagaccgttt gattttcgcc atcaatattc ctctctggaa ccggcgctcc 2448541 atccattgac cgcaggttac gatgtacgcc ggcttctttc attctgtcta accgctcgtt 2448601 taaccaggaa tcaatcttca aggctcgtaa cctcgtggat cgcttgtttc ataatggcaa 2448661 ccatttccga gagctcttca gctgtgctgg caagaggagg aagaaatgca atcacgtccc 2448721 caagcggtct tgtcagcatt cctaactctc tcatttttaa ggaaactttg tatccaatcc 2448781 gccgatcagc cgggtaaggt tctttagttt cctttgatcg tacaagctct gcaccgcaca 2448841 taaagccaag ctgccgaata tccccaacat gaggaagagc gtgcagatct tgaagaagaa 2448901 aatggagctt tttacttttt tccgctactt gttccacaat gttttcagat tcaaataatg 2448961 ccagattttc aagcgcaacc gcacagccaa gctgattgcc tgtataggaa tggccatgga 2449021 aaaaggtttt taggttttca taatcatcat agaatgcctt atagatgtct tcagtggcaa 2449081 acgtaacggc aattggcaaa tagcctcctg taatgccttt accggcagcc atcagatcag 2449141 gctggacatt ctcgtgctcg cacgcaaaca tttttcctgt acggccaaag cctgtagcga 2449201 cttcatcaac gatcattaag acatcgtatg ttgtacatag ctcgcgcacg cctgccaaat 2449261 atccttccgg catcacgatc ataccggacg cgccttgtac cattgattca atggaaagcg 2449321 cggcaatttc ctcatgatgt tcctcaagca gctgtgcaag ctctcggagg cactgatcac 2449381 ggcactcatc aggatcaccg ctttcagaac gatacacata aggaatcggg gccttgtaac 2449441 tctcgaacat caacgggccg tatacgtggt gaaaaagctc aattgaaccg acactgacgg 2449501 cgccaatcgt atcaccgtga tacccgtttt tcattgcgat gaatttttgt ttctcgggct 2449561 tcccgatgtt cttccaatac tgaaacgcca tttttagggc tatttccatc gcctctgcgc 2449621 cgctgtctga ataaaagacc cgcgtgagct tttttgggct gatgtcgatt aatgtttcgg 2449681 caagctgggt tgctggaaca ttggtcatgc ccaataacgt ggagtgcgca atttttccga 2449741 gctgtttttt tatggcgtca tctagttctt ttttgcggtg tccgtggaca ttaagccaaa 2449801 ccgatgaaaa accgtcatag tattccttgc cgtttatgtc tttgactttg attccagtcc 2449861 cgctttcgat gattaagggg ttttcatcat aatctttcat ttgggtaaat ggcagccaga 2449921 ggtgcttttt acttttttct atcaaatcat gagtcatgat cttcctccca ctctattaaa 2449981 ataggctgct tctccaggtc atgtatgtac gtgtttacat cattggatcc atcaataaaa 2450041 aagactcggc agccctcttc agtcccgtat tctttcattg ctgtaatacg ctgatagccc 2450101 attttcttac ccgcaacata gcctgttatg taatccggat cgtccgacca gcataattct 2450161 gcaacgactg ccgggtgccg gcttaccttt gaagcgagcg caagggcctc ttttattctt 2450221 gaatgagctg gcacgtgact gtgaagcgcc catttttcaa aattagcgtc cggccaatcc 2450281 attctggaga cccgcacccc tttttctttt gtttgatcca ttcgcttgcc tgtatgaata 2450341 tcaaacaaca ccgcacccct gacatctgac cattcaggga tttgttcata tgctttttca 2450401 atcacgtctc gtgaaacgcc ttctttttcc aataacaatc gggcaagctt ttgtccttct 2450461 tccgggcagc tcacttcatt cgtatgcaca ggcaatggct gaatggtttt tatcgattca 2450521 tgtacctctt caaattgaat ttgcataaaa tcaggttttc ctcttgaatg ggataaccct 2450581 ttttctaata aagcattgac tgtatgcttc atctcatgga aaggaataag ccgttctccg 2450641 ccggatatat gctttccgcc gtcttcatga gatccattca ttgaagccct cattctgaca 2450701 ctataaaaag tttcttcttg catcatttct cgccctttca ctgataactg aagaacgtgt 2450761 agcgcttctc acctaaattg ttaaccaatt atattcaaag gttaacaatt agaatatatt 2450821 attctctcct gtttctgtca atagaagaaa ggatcgattt atggcagttg gttaaaagga 2450881 aacaaaaaga ccgttttcac acaaaacggt ctttttcgat ttctttttac agtcacagcc 2450941 acttttgcaa aaaccggaca gcttcatgcc ttataactgc tgtttcgaaa tgtcccgaag 2451001 cagaacggac cactcggtag caatcagcag ctccctgtcc agcatagaca gctgtcaatt 2451061 ctttttcgat tttgtccacg ccctcagccg gcgttaaccg atcgtgtaca ccaacaagac 2451121 taaggtgcgg gcgcggcgcg atcaggcttt ggatctccga tgcggaaaaa tgctttgcaa 2451181 gcgatgggac gtaataataa aagccgtgcc tgtcaagatt ctgtgttttg atcagcacgt 2451241 gatgatccac ctggctgcac aaatccacac acaccttaat ccggtcatcg agcgccgctg 2451301 tccaccacgc catcaaacct cccatagaca tgccgatggt tccgatcctg tcaggctgaa 2451361 catcagagcg tgactgcata tagtctaacg cacttaaact gtcataaatc atcatccccc 2451421 acatcacttt tccggtgaga agcatttctt taaatatctc gctttccgct tttccccgcc 2451481 gatctccaaa cccccaatga tcaatcgcaa gaacgccgta tccgagtgaa gtaagctcat 2451541 cagaaaaaga aggcgttttc aaataatccg ctccctcaat cagctcactt tttcccctat 2451601 catactggcc tccatgcgaa tgctgaaaca atacggctgg gcacggtcct tctgttttct 2451661 tcggcttcac aaaataagcg ggcgcctttt catgtccatt taaatcgagc aggagcgttt 2451721 caacgatatt ttcttctctt tcttcaatac gtaatgtctc aacactgatt ggcctccgat 2451781 caggcaaatc accaagcaat cgaaacagtt gctttcttct ttcggctctc atcccatcac 2451841 ccttccttat tcgcttactt cacatttacg agacagatct gggttcccct ttatttttcc 2451901 aacataaatc acatcattta ctaaatattt agtaaatatt atggaatatt tcgaaaacaa 2451961 ttattgtaac cgcttacttt tatatgataa tatcaattta tcaaaaacag atgagttaat 2452021 attttactaa atagatgaga gggataccca tggttcgtat taaagatatc gccttgaaag 2452081 ctaaagtttc cagcgcaact gtgtccagaa ttttaaatga agatgagtcg ctttctgttg 2452141 cgggcgaaac gagacaaaga gtcatcaaca tcgctgaaga gcttggttat caaaccgttg 2452201 ccaaacgccg aaaatcccgc gggcaaaaac agcgggctca gccgctgatc ggtgtgctga 2452261 gctgtctgtc ccctgatcag gaaaggcagg acccttattt ttcttccatt cggaaaggga 2452321 ttgaaaagga atgctttgaa caggaaattt tcattacaaa ttcgattcat ctcggctcct 2452381 ttcaggaaca tatctttcgg gaattggatg gtgtcattgt catcggccgt gttcatgatg 2452441 aagcggttaa gcatatcagc gggaggctgg agcatgccgt atttatcaat cattcaccag 2452501 atccgcaagc atacgattcg attggcatcg attttgaatc ggcttcacgc caggcgattg 2452561 atcacctttt cgacttaggc tacaaacggt taggctacat tggcggacaa gaaaaagagc 2452621 atacgctgaa ggacggccaa agcattcgca gaacgattga agataaacgc ctgaccgctt 2452681 ttttggagtc agccgccccc cagcctgagc atgtgctgat cggagaatac agcatgcgtg 2452741 agggctatcg cctgatgaag aaagcaatcg atcaaggcca tctgccggaa gcattcttta 2452801 ttgccagcga ttctatggcg atcggcgcat taaaagcgct gcaggaagcc ggactgcaag 2452861 tgccgcggga taccgcaatc gtcagcttta acggcattga ggaagctgaa tttgccagca 2452921 cgcctttaac gacggtgaag gtatacacag aggaaatggg ccggacaggc gtaaaactgc 2452981 tgcttgaccg tctcaatggc cgaacgcttc ctcaacatgt caccctgcct acaacattaa 2453041 tcgtaagaca aagctgcgga tgtacagcaa aggaggtgac ataagcaaag attcatcacg 2453101 atgataagga ggaaaagatg aaacacactt ttgttttatt tctctctctt attctgcttg 2453161 ttctgcccgg gtgttcagca gagaaaagct cagcagatac cgcaaaaaag acgttaacca 2453221 tttattctac aatgtcaacc gacagtgaaa gagatacgtt cagaaaacta gcggcagcat 2453281 tcgaaaagga acacagtgac attcatgtca gccttcattt cccaggcaat gactatgaaa 2453341 atatgatgcg tgtcagaatg gcggccaatg atttgccaga tctattcgat acacatggct 2453401 gggggaaaat caggtacgga gaatatacag cggatctccg ggatatgaaa tggactcaag 2453461 atcttgatcc caatttaaac agcatcctca aaaataaaag cggaaaggtg tatgcctatc 2453521 caatcaatca ggcaaaagac ggtctggcgt ataatcgcaa tattttagac cgttacggca 2453581 ttgctccgcc ggaaaccatg gatgacttta tcaaagcact gagaacgatt aaagaaaaga 2453641 gcaagggaag cattgttccc ttctggtttg ccggatatga caaaagctca ttcgcccaat 2453701 attacgacca attcgctaca cctcttctca tcacagaccc tgcccataat gaaaaaaaac 2453761 agctcatcaa cggcactttt caatggagta aattcactta tttatcagaa atcctcaaac 2453821 aaatgcagaa agaaaaattg atcaatatcg acgccgtcac ggcaaaaaaa tcacagctca 2453881 ttgaattaat ggcccaaaac aaaatcgcct ttacaatgca aggcggcaca ctcggccaag 2453941 acgttgccca gatcaacccg aacgtcaagg tcggcattat cccgacacct gccatccatc 2454001 ccggtgatga cccgatatgg atcggcggtg aacgctacac ccttgcagca tggaaagatt 2454061 cgcctcaatt aaaagaggca aaagatttta tcgcatttat ggcccgcccg gccaatgcca 2454121 aacaaatggc tgaagccaca tcgcttcctt cagggctgac caatgtgaaa gctgatattt 2454181 tctacgcaaa cgattatgag tattatcaag atgtcaaagt cgagccttac ttcgaccggt 2454241 tatacttgcc aaacggaatg tgggatgtcc tgggcacggt tgggcaggag ctcgcggctg 2454301 acattttggc gcctcaagac atttcgcaga agctgggaag agaatataaa cgactccggg 2454361 agcaatccga aacacaggga gctgaaaaca atgagtgaga tcgcaaggga cgttcatgtg 2454421 aaacaggtta agccaaaaaa gcagtcctca ctttggtgga tgtacattcc tgctttgctc 2454481 tccgttctgg tctttatgat ttacccgttt gtgaaaggca cattgattac ctttacaaac 2454541 tggaacggat tttcacaagt ctaccaatgg gttggattcg cgcaatatga aaggctgttt 2454601 tctgatcctg atacttggca tatcttaaaa aacacgctgc attacgggct tggcagcacc 2454661 ttttttcaaa atgtggtcgg gcttctgtac gctctcctct taaatcaaag cattaaaacg 2454721 aaagcggtaa caagaacaat tgtgtatttg ccggtgatga tcagcccgct cattatgggc 2454781 tacatttggt actttttctt ctcctatgac ggaggcgcgc tcaacgattt gctcggggtc 2454841 ttcggcatca gccctattaa tgcgctcgcc agtccctcgc tcaatccatg gatcattgtc 2454901 atgattaaca cctatcaata tgtcgggatc gctatggttg tctacttagc cggtctgcaa 2454961 agcattccga aagactacta tgaagcggcg caaatggatg gcgcgaaaca aggccagcag 2455021 ttttttacca tcacgctgcc gctgttaatg ccctccatta ccattaatat agtcatcaac 2455081 attatcggag gcttaaagct gtttgacgtc atcattgcac tcaccgcagg cggccccgga 2455141 aatgcgtcac aatccatgtc cacgtttatg tatgatttgt atttcaaacg gcaggatgcc 2455201 ggctatgccg caacgcaagg catatttatg gcatttgtca ttttgatcat cagcttttgc 2455261 gcgcttgcgt actttaaaag aaaggagacg gaaatgtcat gagagccgcc cgtacaaaaa 2455321 gcatgcggat cattacgctt cttgcagcca ttgtggcctg tgcgcatttt attccttttt 2455381 atatcctgct gaccacttca ttgaaagcaa aaggagacta cagttcgaaa tggatatttc 2455441 cagccgacat ctcctttcat aatttttcag aggcgtggga gcgcgcttcg ctaggaaact 2455501 cttttataaa caccatgatc atcacaggtt tttctgcctt gttattaatt atattcggct 2455561 cacttgccgc ctacccgctt gcccggcggg aaacgaaact gaataaagcc gtttttgcct 2455621 tgctgatttc cattatgatc atccctccgt taacgtccat ggttcctttg taccgaatgg 2455681 tcgtggacgc cggaatggtc aatacacacg caatcgccat tttcatcaat acagcggctt 2455741 acatgccgtt aaccgtattc ttatattcag gctttatccg atcgaccatt ccaaaagagc 2455801 ttgtagaagc cgcaagaatt gacggtgcag gcatgctgaa aatctttttt acgattgtgt 2455861 ttcctctgct gaagccgatc actgcgacca tctgtatcat ttcttgtgtc tttatttgga 2455921 acgactatca atttgccatt ttctttttac aagatcaaaa ggttcagaca ttaacagtag 2455981 ccatggcagg ttttttcgga gaaaacgcaa acaaccttca tttagttgcc gcagcggcac 2456041 ttatggcaat gctgccgatg gttgttctgt ttttggcgct gcaaaaatac tttattgccg 2456101 gcctgtcttc cggagcggta aagggttaac attaaagggg gaagcaatat gaaaaagatt 2456161 acatttatcg gtgcagggag cacgattttc gccaaaaatg ttttgggaga ctgcctgtta 2456221 acagaggcac tgaatggatt tgagttcgct ctttacgaca ttgatcccaa acgcctgcag 2456281 gaatcccagc tcatgctcga aaatctaaga gaccgttata acccaagtgt ggccatcaac 2456341 agctatgatg acagaaaact cgccttgcaa aacgcaggct atgtcatcaa tgcgattcag 2456401 gttggaggat acaaaccgag cacagtcatc gatttcgaga ttcctaaacg gtatgggctg 2456461 cgccagacga tcgccgatac agtaggcatc ggcgggatat tcagatctct cagaacaatc 2456521 ccggtcttat ttgatatcgc aaaagatatg gaggaaatgt gccctgacgc atggttctta 2456581 aactatacaa atccaatggc cactcttaca ggcgccatgc tccgctatac caatatcaaa 2456641 acaatcgggc tctgccacag tgttcaagtg tgcacgaagg atttatttaa agctctcgga 2456701 atggagcatg acggaattga ggaacgcatt gcgggcatta atcatatggc ttggcttttg 2456761 gaagtcaaaa aagacggcac agatttatat ccagaaatca aaaggagagc gaaagaaaaa 2456821 caaaaaacaa agcatcatga tatggtgcgg tttgaattaa tggataagtt cggctattat 2456881 gtcacggaat cgtccgaaca taacgcagag tatcacccgt actttattaa acggaattac 2456941 cctgaactga tcagcgagct gcaaatcccg ctcgacgaat atccgagaag gtgcgtcaag 2457001 cagattgaaa attgggagaa aatgcgggat gatatcgtca ataataaaaa ccttacgcac 2457061 gaacgctcaa aggaatatgg ttcaagaatt atagaagcaa tggaaacaaa cgaaccattc 2457121 accttcggag gaaacgtctt gaatacaggg ctgatcacca accttccttc aaaagcggtt 2457181 gtggaagtga catgcgtcgc cgacagaaaa aaaattacac cgtgcttcgc cggagaactg 2457241 cctgagcagc ttgcagcctt aaaccggacg aatattaata cacagctgat gacaatcgaa 2457301 gcggctgtca cacgaaaaaa agaagcggtt taccaagctg caatgcttga tccgcataca 2457361 agcgcggagc tttccatgaa ggacatcatc tccatgtgcg acgatttatt tgcagcacac 2457421 ggcgattggc ttccggaata caaataaaaa ctaggggacc gctctcccct agttttttgg 2457481 ttttgtttcg ccttcccagg ccatcatgcc gccttcaaca ttgactgttt taaagccttg 2457541 ctcatccagg tacttgcaga cgttcatgct gcgcattcct gagcggcaga taaatacgta 2457601 ctctttgtct ttatcaaggg tttccatttt ttcaggaata tcccccatgc gaatatgaac 2457661 ggcttgcggg atcatgcctt ccgctacctc ttcatcttct ctgacatcaa ttaaatataa 2457721 ttcttcgtcc gcctcaattt tttctttcaa agcggctgtg ctgatttctt ttatttccaa 2457781 agaaaacact cctattcaca gtgatcatgt tcagtatatc aaagtcagcc gaacgattgc 2457841 tattctgaga ctgatgaaaa aaaatcccct tttggcaaag gggatttttt ctaggcttag 2457901 tttgccacaa tattgacaag cttcccaggc accgcgatga ttttccgaat cgttttgcct 2457961 tcaagctgct ctttgacctt ttcatctgct tgagcaagct gttccagctg ttctttcgtt 2458021 gcatcggcag gaacctgtaa tttcgctttt acttttccgt tcagctgaac aacgatttca 2458081 acttcatcat ccacaagttt tgtttcatca tatacaggcc aagcttcgta ggcaattgtg 2458141 ccggaatggc caagcttctc ccatagctct tccgctaagt gtggcgcgac aggagaaaga 2458201 agcttcacga agccttccat atattctttc ggcagttctg ttgctttata agcttcatta 2458261 ataaagacca tcagctggga aatacccgtg ttgaaacgaa ggccttcata atggtctgtg 2458321 actttcatga ccgtttcatg atagacgcgc tccaatgttt cacccgcgcc ttcaacgatt 2458381 tttccattaa gctcaccgct gtcttcaata aataggcgcc atacacggtc aaggaaacgg 2458441 cgcgcaccgt ctaatcctga ttcagaccag gcgattgaag catcaagagg tcccatgaac 2458501 atttcgtaca atctcagcgt atcagcaccg tgagaggcca cgatttcgtc aggattgaca 2458561 acgttccctt tagatttact cattttttcg ttgttttcgc cgagaatcat tccttggttg 2458621 tacagctttt ggaacggttc tttcgtcggc actacgccga tatcataaag gaacttatgc 2458681 cagaagcggg catacagaag gtgaagcacg gcatgttctg caccgccgat atacatatcg 2458741 accggaagcc atttttccaa tttttctggt gatgccagct gatccggatt gtgcggatca 2458801 atatagcgca agaaatacca gcagcttccc gcccattgcg gcattgtatt cgtttctctt 2458861 cttccttttt tccctgtctc agggtctgtg acttccaccc actctttaat gttcgcaagc 2458921 ggtgattcgc ccgttccgct cggtttgatt tcatccgttt ttggcaaaat cagcggcagc 2458981 tcctcttccg ggacagctgt tgacgttccg tcttcccaat gaatgaccgg aatcggctcg 2459041 ccccaataac gctggcggct gaagagccag tcacgaagac ggtacgtcac tttcttctca 2459101 ccgtttttcg tttcttccag ccaagcgatc actttttcaa tcgcttcctg tttgtgaagg 2459161 ccgttcagga aatcagagtt cacgtgctcg ccgtcgccag tataggctgc ttcctcaacg 2459221 ttcccgcctt ttacgacttc cttcaccgga aggccgaatg ttttggcgaa ttcaaaatca 2459281 cgctcatcgt gtcctggaac tgccatgaca gcacctgttc cgtatgatgc aagaacataa 2459341 tccgcaatcc aaatcggcag tttttctccg tttacaggat tgatcgcata cgctcctgta 2459401 aatacgcctg tctttgtttt cgcaagatct gtgcgttcta ggtcactctt tgattgaatt 2459461 tctttgatat aagcttcaac agcttctttt tgctctgccg ttgtgatgtt ttccaccaat 2459521 gcgtgttccg gggcaaggac agtgtatgta gcgccaaaca gcgtatctgg tcttgttgta 2459581 aacactgtaa aggaatcatc atgtccatct atagcaaaat gaacgtgagc gccttccgaa 2459641 cggccgatcc agttgcgctg catatcttta atgctttccg gccaatcaag ctcttccaag 2459701 tcctcaagga gcctgtccgc ataagcggtg attttcagca tccactgctt cattgggcgt 2459761 ctctctaccg gatggccgcc gcgttcgctc ttgccgtcaa tgacttcttc gttggcaaga 2459821 acagtaccga gcgcagggca ccagtttaca ggcacttcgt caacgtaagc aaggcctttt 2459881 tcgtatagct ttaagaaaat ccattgcgtc catttatagt attcagggtc agtcgtattg 2459941 atttcgcgat cccagtcata tgagaagcca agcgcttgaa tttggcggcg gaagttatca 2460001 atattctgct tcgtaaacac agcggggtcg ttccctgtgt caagcgcgta ctgttcagct 2460061 ggcaggccga atgcgtccca gcccattgga tgaaggacat catagccctg catgcgcttc 2460121 atgcgggaca gaatatccgt agctgtgtat ccttcaggat ggccgacgtg caacccagct 2460181 ccagacggat aaggaaacat gtccagcgcg taaaattttt gtttttcatt attatcaaga 2460241 gtggcaaatg ttttgttttc aagccaatat gtctgccatt tcttttctat ctctttgtgc 2460301 tgaaaactca aagtaaaaac ctccttctga ttgaatacgg cgtgtatggt tcaagtattg 2460361 acgggaagga gaggattata ttcagaatat tcccaaacta aaaaaaactc cctcatccca 2460421 aaaagggacg agagactttc gttttcccgc ggtaccaccc tcgttagcgc ggcatacgcc 2460481 gcactcactt gatactttta acgcagttat gcgtcagcgg cttttcaccg ctgcaactct 2460541 gaggtgagtt cggaaacaaa cttgattgac tttcaccagc cgtcaactct ctgcaacaat 2460601 atctgtttct tactgctcct cttcattgtt cttatcgcaa ccgtaatcta actgtatttt 2460661 atagaattct gttcataagt gcaagcaggt ttgtatacaa tgggaatgta ccctgaacgg 2460721 gcggagattg aggacaatta ttcgggtgga gttttggttt gacgtttgga ctcggccggt 2460781 tcgccgccgc tgttcagttc tctcacaaag tcaaaacttc tgagaacagc ttcaccgccg 2460841 tagcctgaga taatggataa gatgacaagt tgaattcctg aatcggggtc agcggataat 2460901 acaagtaaaa tggaagccgt catgccgata aaccaatctt ccaaaaatcc aaggtagata 2460961 aaccgcttcg tcattctggg cttctccagc ctgcctctct ttttcacatg accgagaatc 2461021 cccatgattc ctccaattac acaagcaatg agtacctgat gcagcatctt catcatcacc 2461081 ttcctaaagc ccttatttcg taaagcgact tcaggccatc cagccccctt aaacgattcc 2461141 gatgattttc gatatctaca taccggcaaa tctgtaaaaa gcttgtttct tccattatat 2461201 gtgaacacat gatcggtaag cttgatgcat tggattcatt tttcacccag tgacattgac 2461261 ctagtcacct atttagcatg tagaaaacct ttccgttcat atgttcaaat tctgttctta 2461321 tttttagtgt atacgaggac aagccctaat gacaaacaac aaactgcact tgcttgaatc 2461381 agaacatgtg ttgtgctacg gttactgtag aattcatttt taaaaagggg aatatcaggc 2461441 tttcgcatag caagctgacg gcctaagggg gatttatatg gctagttttc aatcatttgg 2461501 gataccagga cagctggaag tcatcaaaaa agcacttgat cacgtgcgag tcggtgtggt 2461561 aattacagat cccgcacttg aagataatcc tattgtctac gtaaatcaag gctttgttca 2461621 aatgaccggc tacgagaccg aggaaatttt aggaaagaac tgtcgcttct tacaggggaa 2461681 acacacagat cctgcagaag tggacaacat cagaaccgct ttacaaaata aagaaccggt 2461741 caccgttcag atccaaaact acaaaaaaga cggaacgatg ttctggaatg aattaaatat 2461801 tgatccaatg gaaatagagg ataaaacgta ttttgtcgga attcagaatg atatcaccaa 2461861 gcaaaaagaa tatgaaaagc ttctcgagga ttccctcacg gaaattactg cactttcaac 2461921 tcctattgtc ccgattcgca atggcatttc ggctcttccg ctagtcggaa acctgacaga 2461981 ggagcgattt aattccatcg tttgcacatt gacgaatatc ttatcaacat ccaaagatga 2462041 ttatttgatc attgatttat ccggattggc ccaagtgaac gaacaaacgg ccgaccaaat 2462101 tttcaagctg agccatttgc tgaaattgac cggaactgag ttaatcatta ctggcattaa 2462161 gcctgaattg gctatgaaaa tgaataaact ggatgccaat ttttcgtcgc tgaaaacata 2462221 ttcaaatgta aaggatgccg ttaaagtgct tccgattatg taaaaagatc ccgctcaccc 2462281 agctggatct ttcagattgt tgacaaaatc ctaaaatggt tttcatttta ggattttgtc 2462341 atcttttcag cgtgattgaa aacccttgaa gtctaggaag gacgagcata ggagcggagc 2462401 gaatgttcta attcgtgagc accgaagcgc aggcctgaca acgaatgcga gggtttgtcg 2462461 acacgctgaa agatcccgct cattcggcgg gatcttttat tatgaagaga ttgatgcctg 2462521 cttatttgtt tctttagctg attttatccg tttgtcatat agaagcgttg tggcaatact 2462581 gatcagcagc aataccaaca gagataaaac aagagcccta atgccgtaat gatcgacaag 2462641 cactcctccg aacaggggac caatcattct gccgcctgtc gccgcactgt tgacaaagcc 2462701 ttgataaaag ccttctttcc ctttaggggc aagctgattg gcaatagtcg gcacagcagg 2462761 ccaaacaagc atttctccga tagtcaggat caccatcgca gcgagaaaca tcggaaattg 2462821 ctttgcagtc agcagcatgc tgaaagacac aataaaaatg ataaagccga tgaccatttg 2462881 cgcttttagc gactcggccc attttttcac cacaaaactg acgagcggct ggccgagcac 2462941 aatgagaatt ccgttaaccg tccacagcac gctgtataag gaaagagata ttccaatgct 2463001 ttgtgtgtac gaagcaattg tggttgacca ctgagaataa gccagccatc cgagtacata 2463061 gcctccgctt aaaatgatca gtgcggcaaa ttttgctttg ctgttcacag catcataatc 2463121 aagcacggat gtttgggatg catcgcccgt ttgaatattt cgaaatccga aatatacaat 2463181 aaagaaaaag atcagataca atacggcatt tgccaaaaat acatatgaaa acgagaaaga 2463241 tgccacgaca ccgccaagcg ctgaaccaac ggccacgccc gcgttttgcg cgacatatat 2463301 cgcattaaat gccttccttc ccccttcagg ccataccgat cccgccattg cgtagcttgc 2463361 cggaaaaaca acaccggagc caaagcccac aatcgtcagc agcacaatat aggctggcca 2463421 atcatgaaaa aagacaagac ccatcaggct tgctaacgta atggctatcc caagcataat 2463481 cgatttaaaa ccgccgattt tatcaaacaa aaaacctccg cataaattgc cagccacact 2463541 ggcgccggaa ttcagcatca ggacaagtcc ggctactgtt aacgactttc ctaaatgatt 2463601 atggatataa atcgtattca gcggccataa aaaagaagca cccgtcacat tgataaacat 2463661 tccaatgact aaaattttaa gagcacgcgg catactcatc cccctttctt acctaaaaaa 2463721 gctcatgaaa aaaacgaaac ctaaaacggc tccgtacgaa tccagttatc atagcacatt 2463781 cattctatct gtctctctca catttttcaa ctgatgagcg tgaaaaaatc taacaaatat 2463841 tgtttgaaaa atgtaaaata aatagaaaaa ggggtcatat tatggaaatg gtattagcat 2463901 tcttaggttt tctggcatgt ctcattgcac tgggctatgg attatatcac cttgtcagat 2463961 atgtactgaa aaaggaaaaa cgtttctcaa agagactttt ttggccgctt ttcattggag 2464021 gccttgtgct gctctttacc ggggcagcat tggcagaacc tgacactgcc gcagcaaatg 2464081 ccgagaaaaa atattcagcg ctaaacgccg aatataaaaa cctcacaaaa gagcacgaag 2464141 aacttgagaa agaatataaa tctgtcagct ctgaagcaaa gaaattaaaa gacaacaaag 2464201 aagatcaaga caagcttgag aagcttaaaa acgaaaatag cgatctaaaa aagactcaga 2464261 aatcattaaa agctgagatt aaagagcttc aagaaaatca aaagcagctc aaagaagatg 2464321 caaaaacggc aaaggctgaa aatgaaacac ttcgacaaga taaaacaaag cttgaaaatc 2464381 aattaaaaga gacggaaagc caaaccgcca gctctcatga agacactgga agttcttcaa 2464441 acaatacgag taaaagtgat gaaaccaaaa cagctgacaa agcagaaggc tgtaatatca 2464501 aaggaagcag aaacggcatc taccacacgc caggcagtac atactacgac cggacaaccg 2464561 atccggctga aatgttttgc tcagttgaag aagctgaagc cgccggttat cgggcgccaa 2464621 aacgataaac aaaaagctcc agaatgtctg gagctttttc tgtttcacaa cgacgattta 2464681 atgaccttct tataataaag aactgacaga aaaccaaaaa tggagtagag cgcagtatat 2464741 aacaccatca ccataatcat aggcgcccat acctctgatc cgaataagaa ccagccggat 2464801 tggacggcaa agtaactgtg gaagaggccg acaacgagcg gaatgccgaa gttgtacatt 2464861 tgtttgatgc gtatcccctt tatcaggtcg ccctgcgtaa agccgagttt tcttaaaatt 2464921 gtatagctcg gtttttcatc ttcactttca cccatttgtt taaaataaag gatacaacct 2464981 gatgtaatca ggaacgttaa ccctaagaag ccgacgatga acatcaccat accaaacagt 2465041 gatttttgcg cagcgcttgt atctagtctt gataaatgct cgtttttctt gttcacctgt 2465101 tgaaaaagct catttgcttt ttccatttga tcgtcatgtt tcacattgac gccgataaat 2465161 gtagattgcg ccagctgaat gcgggggtct ttatccttgt ccagctgttt aaacaggctg 2465221 tcatccacaa tgacagcggg catgcccccg cttgtaaacg tgtaggacac aagaaactct 2465281 tctcttaatc ctttatattt taatggctgc gtctcgtgct tgctttttac tttaataaca 2465341 ccagagtcct tgaaaaccat tattttttgc agcaagtcgg tgtatcctga gaaaacggct 2465401 tctccagccg ccacatcgac tccttttaca tctttgtcgc taacaacagc aagctgcata 2465461 ttgccgggat cgccctgcat ctctttcgga gttccatcca taatatttgc aatgtcaaca 2465521 tttgcttgca ggacaggtgt tgcctttttt acaaacgaga tgttgctttc cctcaatttg 2465581 ttttcaaata acttggcatc tttctcattc atgaatgaaa aatcagccgc tacattttgt 2465641 tcagcggtct tttccgacga gtaatacgag atgtaagcaa gagataacag cccgatggcg 2465701 agcgctgaaa cggttgtaat aatcgtcagc agcagcgcat tcgatttcat tctgaacatg 2465761 atcgaagaca gtgacagaac ctcagaaata tttaagtagc cgcccttgct ttttcgaatg 2465821 atattcgaga taaacgtaac tgatccttta taaaacaaaa acgtcccgat aatgacgctc 2465881 cccagaatga agctcatcgc aacaaacagt tcattaatgg tcttaaattt tccgccaaac 2465941 agctcagaag acacatagta tcctgtcaaa atcaacacga tgcctaaagc gccgatcagc 2466001 atttggaaaa atgatatttt cttcactttg tcttcagtgg aggacgttac tttaaacaaa 2466061 gataaaatac tctgtttttt gataaacgta taattcatga tcatgatcaa aaggtaaatg 2466121 ccgcagaaca caatgaccgt ttggaccaag gcctgctcag aaaaatgcag tttcgcatcc 2466181 gctttgacat cgacaatttt gaacagaatc atcaagacaa gcttcgatat cgaaaacccg 2466241 gccgctaccc cgatcgctaa tgaaccgaaa tacagcatga cattttctgc acttaagatg 2466301 cgaaaaattt tatgcttcgt cattccaatt aattgaaaca gcccgatttc tttactccgt 2466361 ctcttaataa aaatcgtatt ggcatataaa atgaagatcg ccactacagc cacaagcaaa 2466421 atcgaagcgg ttttaatagc cgcggctccc ttgattgaag ccttcacttc gttaattgct 2466481 ggatcatact gcagcgtgac aaaggcgaaa taaagcgcca cgctaaagat gagcgcaaac 2466541 acatacaaat agtaattccg gagattcttt ttcaaatttc gcaggatgag ctgattaatg 2466601 ttcatgctgc accccgccta acacgccttg cgttttcata atatcctgga aaaacgtttg 2466661 cctgtcctgg ccccctttat tcagctgtgt atacatttgc ccgtccttaa taaaaatgac 2466721 tctgccgcag tagctggcag cgacgggatc atgggtaacc ataataatcg tcgcgttgcg 2466781 tttttgattg agctggctca gcttatttaa tagatcggag gccgatttcg aatcgagcgc 2466841 gccggtcggt tcatcagcga aaataatgct cgggtcatga ataaacgctc ttccagcgga 2466901 tgttctctgc ttctggccgc cggaaatttc attcgggtat ttatcccgca attcatatat 2466961 tcccagttcc ttggcaactt cctcaaactt gcgattggct tccttttttg atagtttcgt 2467021 gatcgataaa ggcagaagga tattctcttt cactgtcaat gtgtctaaca aattgtaatc 2467081 ctgaaagata aagcctaaat gctgttttct aaattcagcc agctgctttt ccttcatagc 2467141 cgtcatgtca tttccattaa tatgaatggt tccgtgactg acctgatcga ttgaggacag 2467201 aacgttgagc aaagtggttt ttcccgaccc ggaagcaccc ataatactga cgaattcgcc 2467261 cttttcaatg tgaatatcga tgcccttcag cacttcctgt ttattcagct tgtttccata 2467321 actttttcga attttattcg cttctaaaat caccatttac gcagtctcct ttatattgga 2467381 taatctcatt ataaaaagga atgccgggct tttccttcga tacggcgaac aaaaaagaaa 2467441 agcatgtgac attttcgtca cacgcttatg acatgttcaa attgattccg tattggaaag 2467501 gttaatgtaa aaactgttcc cgcaccaaac tccgactcaa catcaatatg gatcaataac 2467561 ggcgccgctg ctttttttgc caagtacagc cccatgccag ttgacgcttg atcatggtga 2467621 tccgttgtgg atgtaaaccc tttatcaaaa atacgcggta catcttttgg atcaatgccc 2467681 ctgccacaat ctttcacttg gagctgcgtc tgttcccctt tttgaaagct tttgatctcg 2467741 atttcagagg cttcgctgta tttcaccgcg tttgtcagca gctgcctgat gataaacgcc 2467801 agccattttg catcgctcag cacttctttg gcctcgagct gtatgtcaaa accgatccct 2467861 ttttggatac accacgattg taaatctttg atttctttaa agatcaaagg ctgaagctga 2467921 atgaattcta ctgacaggtc gttttcaata aatgaaatgc gtttttgatg aagctgctga 2467981 tcaagaagca ggtgaatacg cagccattca tatgacagct gggatttcag tgctttttct 2468041 tccattctat caatgattaa atgcatcgct gttaatggag ttttgacctc atggatccat 2468101 gccatcagct catctttttc attttccaat gctaagcgat gccgtgctgc ggtctgcttc 2468161 aagtgttctg tttgcccggc aatgcttctt tcaaccattg cttcaaacgg cgtttccggt 2468221 tcatttatgg ctgtcacatc gagattgttc tcccatgttt tcaagctttt ataaaacgct 2468281 gtttctttcc gatagcggaa ccaaaggaat atgataaaaa acaagatgca caaatacacc 2468341 atataaagta cattcccaaa tgatatggaa ggatcgacaa aagcaatgaa cagcatcaaa 2468401 gcctgctgaa acaaaaacgc ggcaatccag ctccgccttt cgataaggaa tgctttaatc 2468461 atagaacttg tcctcttcct tcgcgatgta gccctggccc acctttgtct cgatatatgc 2468521 accaagctgc agggcgtcca gtttttttcg caggcgattg acattgacgg tcagcgtatt 2468581 atcactaaca aaacgctcat cgttccacaa gcttctgatc agctcttccc ggctgacgat 2468641 cttgtttttt tgctctatta attgttttag aatgaacatt tcatttttgg tcagttcaac 2468701 agatcctttg tcattgctga cgaggttctg ctccgcgtct acagcagcgc cgcaccacgt 2468761 tttaatcgta ctcggctccg tattataatg gtgcacacgc cggaacatcg cttggatttt 2468821 cgcgatcagc acatcaaaat gaaatggctt ttgaataaag tcatctgccc cgagctgcat 2468881 ggacatcacc atatcagcag gatgatcccg ggaggataaa aagagaatcg gaacatttga 2468941 ccgggagcgg atcagacggc accaatgaaa gccgtcaaat ttaggcagct gcacatcaat 2469001 aatgacacaa tcaggattaa ccgccgcaaa ttcctgcagc acctgactga aatcctgaat 2469061 gccgtataca tcataggacc atcccgttaa acgatccttg atttcatgaa acagcgattc 2469121 atcatcttca atcagcaaaa gtttaaacaa tcgactcacc gcactttttc cttttttatc 2469181 aagtgtatag caaaacgcca gcatgcgcta tagaaaaagc cggctgtctc agccggctcg 2469241 ttcgcattat aattctcttc tcaacgctgt cagcacgttg gttttggtag cttttctcgc 2469301 cgggttcatt ccggaaatga ctgcgacccc tccgcaaatc acaacggcaa tgatcacaag 2469361 gctcgccggg atgtaggaga atgtgtaatt caaatcgccc gcatcgccac cgcttgtggc 2469421 cgcaagaatc atcggaacgg ccaggttgac aaggtagctc acgccgtaag aaatgataat 2469481 cccaatcaca cagcctaaaa ttccgatata cgcgctttcc atcaagaaca ttcggcgaat 2469541 gattgacggg ctcgccccaa tcgctttcat aatgccgatc tcttgcgttc tctctgtcac 2469601 cgccatcgtc atcgtgttaa aaatgccgat cgctgaaatg ataactgcga tacatccgac 2469661 aaagatcagt ccgattttga agaccatgaa gaaggtattg gctccctcaa gttcagtagt 2469721 cactgatgtg acatagtacc cgtcatctgt tagatcattt gtcagctgtt ccacattctc 2469781 aaacttatca gcaaaaacac caatgttcgt ttcaacattt ccgcctttga aatctaagaa 2469841 ttccgaaaaa tcttttttga attgatcact gataaaaata tttgagtcct ccatccagtc 2469901 ttgagatggt ttttttgtaa taccgacaat tttaaagtca tatgtttttg tttttgtaac 2469961 atcccctgtt ttagaatctg tcttcgatac acttagttca attgttttat ttagaatatc 2470021 tttcgtatag ccctttggtt cttttatatc ttctggattt ccttttgctt cctcgatttt 2470081 tttgttatat tcttccgatt cttttttcgt taataatctc tttgcgaagt cgtatcctac 2470141 tacgatttca ttttccgact ttgcgactct tcccttttcc aattccatat tggcctttaa 2470201 ttcatcattc atattagtaa aaatgagatt tgagctttca tttgtacgat tgcctaaagt 2470261 agctttgttt ggttcataca cttgcgttct ttctacaact gaccttacgt gatcatactt 2470321 ctctaaatca gcttttttaa tcggcttgtc tccttccttg cccattacgc tgactttcgt 2470381 tacaatctgc tggctcattg tcatatctgt aatcgtcttt tgaatcccaa atccaacgga 2470441 cgacaacaca accaaaaacg cacacgccat tgttgtcgcc agaatcgtca taaagacgcg 2470501 aagcctgttt ttcttcatat ttcttctgat aaaatgaacc tgatccttaa acctcaacgg 2470561 taattcctcc ttttagcaca ccatcatgaa gctgaaattt tgaatgtccg atagaagcga 2470621 cttcatcatc gtgagtaatg atcacaaatg taatgccacg ctcacgattc agctgctgga 2470681 tcaattccag cacttcatgt tccgtttctg aatcaaggct tcccgtcggc tcatccgcta 2470741 agataatcga aggatttaaa atcaatgctc gagcaatact gacacgctgc tgctggccgc 2470801 ctgacagttc attcggataa tgagcggcgt ggttttccag accgacgcgt ttcagcatgt 2470861 cctgcacctt ttgcttccgc tcagatggct tgattccttt taacgccagc ggcatttcca 2470921 cattctcata cgtcgttaaa cccgggatga gctgaaagct ctgaaaaata aacccgaaat 2470981 ggtcaagccg aaattgcgcc cattcctttt cattaaaccc cgtaacatca gtgccattaa 2471041 tgacaatccg cccttttgtc ggcgatatgt agccggaaat taaattcaaa agcgttgatt 2471101 tccctgagcc gcttcgtccg acaatgcagg cgatttcccc tttcgccacg ctcaatgaaa 2471161 catccttcaa tactggaact tcattctcac ggcccttttt tccgatcgtg aaagaatggt 2471221 cgatatgctg aacatcaatc atatgttctc tctcccttac aaaagtttca tttttttata 2471281 aatcgcaaaa taactaatca agaaaccgat taccgcacct gtacccatgc caatgagata 2471341 accggcaaag ctctcgcttg cagtaaatcc aaaatagccg aagcccatga ttcctatgat 2471401 aataacgatg atctgcaccg ggcggttaag cggcttccat aagaagaaat atccgtttct 2471461 ttcattagac attttaacaa agctaatata gccgatgatg taaaaaatga tagtcatgat 2471521 agccggaatg actaaataat atggtgaatt ctcagcccat ttcgagtcta cataaattat 2471581 cggaatgaaa tactgcaccc atttaggtac tggaccatgg ataaaatcta ttgatccgcc 2471641 aaaaaggatc tcgaggttga tcacaggcag gctgatgagt aaaaacggcg aaatggccac 2471701 ggtaaatgag actagaagct gtgcgaaact attgcctgtc aaagctcctc cggccataac 2471761 caaagaataa gccagcatgc taacaataat cattcccaag ctgtaattgt gaaaataaac 2471821 ggcctgatct ggcttcaaaa gcatgatcag caaaacagac aaaacataac ctatgagctg 2471881 cggcaccaca atcaccattc cgccggtaag gaacttcgca tgaaatatct gccctcgtgt 2471941 atatggaagg cttaatgtaa aatcaaagaa gctcttgcta cgttcaatcc caagctggct 2472001 gaccgccaaa acgactcccc aaatccaaaa caatgagata aatgagctat ttaaataatc 2472061 aacgctgaat acgcaggggc cgacccaatt ttcttttcca gtgacacagc cttgatagat 2472121 gagatacata tttaaaattg ataatggatt acctaatata aaaaccaaaa tggtgataac 2472181 taaggcgact ttattctgcc gccactcttt gtaaagcagt ccggaatccg gcaactcact 2472241 tccctccaaa cctaaggcat ttcttacact tttgttttct tataaataga gaagtagctc 2472301 acaaagaatc cagccactgc tccaatgatc atacccaaaa tataaccaat aatggaatgt 2472361 ccggtatagt atccaaataa accaaatcca aggatgccga aagccataac cagaatttgc 2472421 accgggcgat ctaatctgtt ccataagaaa aagtgtccgt tccgttcact tggaagcttc 2472481 ttgaagctta taaagccaat caagtaaaat agcatgctca ttacggctgg aatcaataaa 2472541 agatatttac tgttaatcag ccattcattt acaacgtaac taatcggtac taggttcgat 2472601 aaattgcttg ccagagagaa ataactctca ggggaaggga atatttccca tatattcgca 2472661 ccaaaaacaa cttctaggtt tccaaccggc aatgcaataa ttaaatacgg caatatagct 2472721 gctgaaaacg ccgttaacag ttgggcaaaa gcatttccag ttaacgctcc ggcggccatc 2472781 accagtgaaa aagccataaa acttatcacg attactccaa tgctgctgtg ctcaaaaaag 2472841 tagacgtgtt cagggttata gacaagaatc agcagccatg caagtaaaaa gccaatcaat 2472901 tgtgacagca caatcacaaa accgcctaac caaaattttg tctgaaaaat ttggcttctg 2472961 ttatacggga ggcttaatat aaaatccatc gtgcctttcg aacgctccat tccgaggaag 2473021 cagaccgcca aaatgacacc cggcacccag ttgatatcta tcagattgct tatggaataa 2473081 ttcacaataa aatcacaata ttgcgggtct tggcgatcaa gacacccttg ataagacaaa 2473141 tacgtattaa cgatagaaag cggatttgcc aatactaaaa acgcgatact taacaaaatc 2473201 accacttgat tctgcttcca ctctcgatag aggagacctc ggtctaccat ctccgcttcc 2473261 ctccaaactt cgcaatgaac acttcttcca ggttgacagg aagctcattc cacacttttg 2473321 gcttcagctc tctcaaaaag ctctttttct cctcatcgct tttcggaatc agcactgtgt 2473381 aaaacacgcc ggcctgatcg agcatcggaa tgttttgctc tctgatggcc aaattgacat 2473441 ctgtatcgaa ggccatttga attttaatgt attcttcttt taactcatca agatccatga 2473501 cgttggtcag gctgttatct tcaagaaaac caattcggtt gcacatccgc tctatgtctt 2473561 caagccggtg ggacgtaatc aggatgctcg tatcacgctc tgccacttca tcgaccatca 2473621 gctgcagcac atcatgcctt gtcaccgcat caataccatc cgtcggctca tcaaggagga 2473681 tcagcgccgg tctcgccgca aacgacagaa cgagcgatag ctgctttttt aagcctgtcg 2473741 acagctcacg gtattttttc gtttccggaa tttcgtatct gttcatcagc tcattcgcgt 2473801 acgtgacatc aaatttcgga tatattcttc tcaaaatatc gactaactgc ttgtatgtat 2473861 acttatcgta aaacggattt tgaacaggca tgtagatgat attttgtttg actttcgggt 2473921 gctttttgat ttctacgccg tcaaataaaa tcgttccgct gtcagcgaaa atgatttgct 2473981 ggattaagcg aagcatcgtc gttttgcccg atccattgcg tccaagcaat ccaaagattt 2474041 ctcctttttc gattgttaat gaaacatctt ttaatacttg attgccgtca atcgcttttg 2474101 acagctgccg cagttcaatc attttttttg cctcccttca catcagcgct gatttccttt 2474161 atccattcgt gcagtttttc cagctcaacc cctgcatagt gtgcatcgat gatgagctgt 2474221 ttgagttgct ctttaatcat cgtcatcttc ccttcaacca gtgtcgtttt tgcattctcc 2474281 gatatatagg tccctctgcc ccgcagcgtt tcaataatcc cctctcgctc aagttcttta 2474341 tacgctttgc tgacagtgtt cggattcgca ataatgatcg ttgccaattc tctgacagaa 2474401 ggaagcttat caccaggctt catgatccct ttcaaacaaa gctctttcat ttgctgaata 2474461 atttgttcgt aaatgggtgt tgagcttctt ggatcgattt gaatcattta cttccctact 2474521 ttctatacga tctgaacctt ttatagataa aaatgatcaa ttatactttt ttgccattca 2474581 aaaccgatca tcacaagaac aagaaaaaaa gaacaagcga tcacagatgc cgcaatcagc 2474641 attggcacgt tacgtttgtt tcgtttttta tgtttcataa ctgcctccct taatgtcaat 2474701 atataaatga ttttatatta gtgtctatag tgtattactt caattagtac acttaataca 2474761 ataaatactt tgactcacaa agtcaatcct ttttttacaa aaaaacggac ccttttaaaa 2474821 gggtccgttt tcctacacat caagagggtg ctgcaggatc atattatttt gcaaagattg 2474881 aagctgaagt ctcattctgt acagctgttc tctctgctga tcatttgacg acagccatag 2474941 tttattcaag gcatttaccg catcttctag ctgcatttgt gcatcactat attcttgatc 2475001 gttataatgc tcttgtttag aagcgatttt cagctgttct tcagcataat cataggcctg 2475061 catacattgc tggagatgtt catctactga ttgtcttgtt gccacagtaa cccctcctct 2475121 tggtaatgga aatcatccat cattcatatt gtagcctcat ctgactttat tcaataaagt 2475181 aatttatggt cgatattcat ttgttctctt gtgaaatgcg tgctacaatt ttaggatgca 2475241 atcgtacgca aggaggcaca tgaattgtga tgcagaacaa tccttttcct tattcaaata 2475301 cggaaaaacg ctatcataca ttgaattatc atctcagaga acatttcggc cataaggtgt 2475361 ttaaagtagc gcttgacggc ggttttgact gtccaaatcg ggatggcacc gtagcccacg 2475421 gaggctgtac gttttgcagc gcagcaggct ccggagattt tgctggaaac cggaccgatg 2475481 atttaattac gcaattccat gacatcaaaa accgcatgca cgaaaaatgg aaggacggca 2475541 agtacatcgc ttattttcag gctttcacaa acactcacgc cccggttgag gtgcttcgtg 2475601 agaaattcga atccgtcctc gccttagatg atgtggtcgg catttcgatc gccacacgcc 2475661 cggactgtct gcctgatgat gtcgttgatt acttggcaga gctgaatgaa cgtacgtatt 2475721 tgtgggtgga gcttgggctt caaacagttc atgaacggac tgcacttttg atcaaccgcg 2475781 cacatgattt taactgctat gtggaaggcg tcaataaatt aagaaaacac ggcatacgtg 2475841 tctgctcgca tattatcaac gggctgcctt tggaagaccg ggacatgatg atggaaacgg 2475901 caaaggccgt cgcagatttg gatgtccagg gcattaaaat ccatctgctt cacctactga 2475961 aaggcacgcc gatggtcaaa caatatgaaa agggcaagct ggaatttctt tctcaagatg 2476021 attatgtgca gctcgtctgc gatcagcttg agatcattcc gcctgaaatg atcgtccacc 2476081 gcattacagg tgacggaccg attgagttga tgatcgggcc aatgtggagc gtcaacaaat 2476141 gggaagtgct tggcgccatt aataaagagc tagaaaatcg aggcagctat caaggaaagt 2476201 tctttcaacg gcttgaggag gaatcagcgc tatgattttg aagaaaattc ttccttacag 2476261 caaagaactg ctgaaaatgg ccgcgggaga gggagatatt gtcgtagatg cgacaatggg 2476321 caacggacat gatacacagt ttttagcgga gcttgtcggt gaaaacggcc atgtatacgc 2476381 attcgacatc caagaatcag ccgtggccaa tacaaaggaa cggctcggtg acatgtatca 2476441 agcgcgaaca acgttatttc acaaaagcca tgataaaatc gctgaatccc tcccgcctga 2476501 aacacatggc aaagtggcgg ccgcggtatt taacctcggc tatttgccgg gcggggacaa 2476561 atcaattacg acaaacggca gttctacgat caaagccatt gaacagcttc tcagcatcat 2476621 gaaagacgaa ggtctgattg ttctcgtcgt ctatcatggc cacccggaag gcaaagctga 2476681 aaaaaacgac gtgctcgagt tttgccggga cttggaccag caaacagccc gtgtattaac 2476741 atacgggttt atcaatcagc aaaatgaccc gccatttatt gtcgccatcg aaaaaaaagc 2476801 tcagatcagc aaatgatttg agcttttttc tttgaatttt tcatccagga cattttttga 2476861 aatttccggt aggctctgcc gttgatataa aagaaaaggg aggtttttcc gctggctttg 2476921 atcagcttct ttgcgagccg gacctgcttc gtcttacttt accatttttc aaattatatt 2476981 tgaaagcaat aaccatcgtt aacccggacg tcatacagtt cgggtttcga tttttccata 2477041 aaacgttcac atatagcatg aaacgtatga cttttatctt atcacaaaac tataaacagc 2477101 ctctgcaaaa acacatacct attctttcct gttctctatt ttctatgagc acacacaaaa 2477161 agagcccact gggagctctt tttgtcagct gatatttcgt tcgctggcag cagccgcatt 2477221 ttttttatga aacccttttc catagtacac agccagcaag atgagaaacc atatcggccc 2477281 gataatcacg gctactcttg tatcagggct gtaagccata agaatgacga cgaatgctag 2477341 aaatgccaat gacacataag acgtaaacgg aaataaaggc attttgtact ttaattgttt 2477401 cttttcttcc ggcttcaaac ttttcctgta ttttatttga gaaagcaaaa tgattgccca 2477461 cgtccaaatc gctccgaacg tcgcaatact tgtaacccaa gtaaatacct tcgcagggac 2477521 aacatagttt aacagcactc cgactaataa agcgcccgct gaagccagaa cagctttacc 2477581 cgggatgccg cctttcgtca gctgaccata tgcttgtggc gcctctttct gttccgccaa 2477641 gttaaacagc atccgccctg tgctgaaaat accactgttg catgaagaca gcgcggctgt 2477701 caacacgaca aagttaatga tacctgcggc cgatggaatg cccacttttt gaaatgtgag 2477761 aacaaatgga cttccttgag agccaatttc ctgccacgga taaatagaca taatgacaaa 2477821 taaagcgcct acataaaaaa tcaaaatccg ccaaaatact gtatcgattg ctttggctaa 2477881 cgatttttgc gggtttttta cttcgccagc cgtcaccccg atcatttcaa tccctaaata 2477941 ggcgaacatg accatttgaa gagacaataa aacccctttt aatccatgag ggaaaaatcc 2478001 tccgttgttc cacaaattgc tgattccggt tgcaatgccc ccattgccga ctcctgcaat 2478061 aatcatcaat aaaccgacag caatcatgga taagattgca acaattttaa tcaatgcgaa 2478121 ccaaaattcc agctcgccgt aagctttgac agccaggaaa ttaacacccg tcataatgac 2478181 cagtgccgat aacgcccaaa tccagtttgg cacgtccgga aaccagaacc ccatatagat 2478241 gccgacagca gtgatttcgg ccatacaggt gacaacccat aaaaaccagt agttccaacc 2478301 tgttaaatag cctgcaagcg gtcccaaata atcacgcgca tacctgctga aggagcctgc 2478361 gaccggtttt tgaatggcca tttccccaag cgctctcata ataaaaaaca tgaccaggcc 2478421 gcttgcggca tacgctacca aaataccagg ccctgctaat tgaatagctg atgcggagcc 2478481 gaggaacaac cctactccta tagcagctcc taaagacatt aaagaaatat gcctttcttc 2478541 gagtccgcgg tgcagctctt gtttttgttt ttgcatgctt cttctcccct agaaaaaaat 2478601 atcattatat catttttctg aatattccgt acggattggg taaatcaatg atgatggaga 2478661 aataaaagga taacaacaag gctttcgact actcgaaagc cttgttgtct gttacacaaa 2478721 gatgacttct ttaggctgat ggctcagctc ttcaggcata taccgttttt caatattgat 2478781 gctgtgccag atcataaaga ttagcacagt ccaaatttta cggctgttat cagccttgtc 2478841 cgcacaatgg tcttcaagaa gctgaaggac ataatcctta tggatataag catccgtttg 2478901 gctttcttga ataatattcc gcacccattc gttcatttcg tttttcagcc aatgacggat 2478961 cggtacaggg aaaccaagct ttttgcggtt taatacgtgc tcaggcacaa ttccttcagc 2479021 ggctttgcga agaagatact tcgtcgtgcc gttcttcgtt ttcagctcat caggaatttt 2479081 tgaagcgacg tcgaatacga ctttatccaa gaacggcaca cgcagttcca aagaattcgc 2479141 catcgtcatt ttatccgcct ttaacaaaat gtcgccgcgc atccaagtgt ggatatcgac 2479201 atactgcatt ttgttgatat cgctgtacga gctgctttct gtaaagtaag tcttcgtcac 2479261 atcgcgatat gaaaggttcg gattataatg cttcaacagc tgctttttga cagactcttc 2479321 aaagattttc gcgttaccga tataacgatc ctgaagcgga gtgcagccgc gctcaagcag 2479381 gctcttccct ctcatacctt caggcataac ggcagcaacg tgcagaagca tctttttcaa 2479441 gccggacgga atccgttcaa acggtttaag cgaaagcggt tcacggtaaa tgttatatcc 2479501 gccgaagagc tcatccgctc cttcacctga taaagcaacc gtaacatgtt tttttgcttc 2479561 ttttgcaaca aagtacaacg gaatcgctgc cggatcagca agcgggtcat caaaatgcca 2479621 tacgatcttc ggaagctcat tcatgtattc ctcaggcgaa atgactttgc tgatattttc 2479681 aatgcccagc gccgctgccg tttctttcgc tacatcaacc tcactgaagc cctgctgttc 2479741 aaagccgaca gagaatgttt ttaagcttgg atgaaattcc ttcgcaacag acacaataaa 2479801 ggaagaatca atcccgccag acaggaacga accgacagga acgtcacttc tcatatgaac 2479861 gtttacagag tcatagatcg cgtctcggac ttctttcaca agcttgtctt cttcagtctg 2479921 aaccggcttg aagttcgctt tgaaatacgt tttgaatgtg atatcgccgt ccgggcggat 2479981 tgtgaattgt gaacccggct ctactttttt cacatgggca tcaagcgtgc ttggttcagg 2480041 aacaaattgg aaagacatgt actgctgcaa tgcctcttta tctatttcaa tatcattctg 2480101 agcaaccatt aaactttttc tctctgaggc aaaataaacc tgatcattga tcgttgtgta 2480161 gtacaacggt ttaatgccga atggatctct tgccccataa agcacatgat cgtttttatt 2480221 ccaaatcaga aaggcaaaca taccgcgcag tttggacgcc gcttcttctt tatagtgacg 2480281 gtaagtcgca agaagaacct ctgtgtccga atccgtgttg aatgtgtacc cctttgcttc 2480341 aagttcttct ctcagttcga tatagttata gatttctccg ttaaagataa tccaatatgt 2480401 ttcatcttca tatgataaag gctgtccacc attttctaca tcaataatgc tgagccgtct 2480461 gaatccgaag ccgacgtgct catcatggaa atatccatca ctgtcaggac cgcggtgaac 2480521 gatcatttgg ttcatttgtt tgattagttc ttcttgatca gcggtttgag ctaacggatg 2480581 cttgttaaaa accccgacaa atccacacat agtattgcct ccataattaa aattgtcatc 2480641 attgaacccc tatttataga cgctgtgaat agtatttggt ttcacagtta tgtaaaaaaa 2480701 taaacatgaa tacaacgata aaaaagggaa agccgcttaa ccagtaagcg gctataaaat 2480761 tattctccta acgcttcttt acgcagctgc tccgctttgt ctgtgcgctc ccatggaagg 2480821 tcaacatcgt gacgtccaaa gtggccgtac gcagcagttt gtttatagat cggacggcgc 2480881 aaatcaagca ttttgataat gccggcaggt cgtaaatcaa agttattgcg aacaacttca 2480941 atcagttttt cctcagaagc ttttcctgaa ccgaatgtgt tgattgagat tgacacaggc 2481001 tgtgcaacac cgatcgcgta agcaagctgt acttcgcaag aatcagcaag ctcagccgca 2481061 acgatgtttt tcgcaacgta tcttgccgca taagctgcag aacggtctac cttcgtcgcg 2481121 tccttacctg agaacgcgcc tccgccgtgg cgtgcatagc cgccgtacgt atcaacgatg 2481181 attttgcgtc ctgtaagtcc cgcatcccct tgagggcctc cgattacgaa acgtcctgta 2481241 gggttgatga aatattttgt ttcttcatca atcagctctt caggaacaac cggattgatt 2481301 acatgttctt taatgttgcg ctgaatttgc tcaagtgtaa tttcagggtg atgctgagtt 2481361 gaaataacaa tcgcgtcaat gcggactggt ttgttatttt catcgtactc aaccgttacc 2481421 tgtgttttgc cgtcagggcg aaggtacgga agaatatctt ctttacggac ttcacttagg 2481481 cggcgggcta atttatgggc aagtgaaatt ggaagaggca taagctcttt cgtttcgttg 2481541 cacgcataac cgaacattaa tccttggtca cccgcaccaa tcgcttcaat ttcttcgtcg 2481601 ctcattgtgc cttcacgggc ttcaagcgct tggtctacgc ccatcgcgat atcagcagac 2481661 tgctcatcaa ttgatgttaa aaccgcacaa gtttccgcat caaatccgta ttttgcacgt 2481721 gtgtatccga tttctttaat ggtttggcga accgttttcg gaatgtcaac atacgtagaa 2481781 gttgtgatct ctccgcttac aagaaccaaa cctgttgtca cagatgtttc acaagcaaca 2481841 cgcgcgttag ggtctttctt taaaatttca tctaaaatgc tgtcagaaat ctggtcacag 2481901 attttatccg gatgcccctc cgtaacagat tctgatgtaa ataaacgacg atttttactc 2481961 atgatttgct tcctcctgca caaggcctcc cgaaagacct tgtatatatg atacggaact 2482021 cgctccctct tatacaatgt acagttatat tagagaatgt taattggcat atttatgaaa 2482081 taaaaaaacc ttttccatcg aggaaagggt ttggtctttg tgcctttcac tcttatcgct 2482141 caaggaatca tacaaccttg caacaggtta gcaccttggt tgtctcactc agttgaacat 2482201 aataaataac agagaaaccg gttgctgggc ttcatagggc ctgtccctcc gccagctcgg 2482261 gataagagta tccgctcaat gaaatatctt atcgtaaaag ggtttgcaat gtcaatatga 2482321 ttcagaagaa ataggcacct atattgaggg aaaacaatgg aaatgcacac acaaaaaaca 2482381 ataaatagta tagactattt gaaaatatat gttatactaa ttcacaatta gcaaaacaca 2482441 aaaaacgata aaggaaggtt tcatatgaac tcagttgatt tgaccgctga tttacaagcc 2482501 ttattaacat gtccaaatgt gcgtcataat ttatcagcag cacagctaac agaaaaagtc 2482561 ctctcccgaa acgaaggcat tttaacatcc acaggtgctg ttcgcgcgac aacaggcgct 2482621 tacacaggac gctcacctaa agataaattc atcgtggagg aagaaagcac gaaaaataag 2482681 atcgattggg gcccggtgaa tcagccgatt tcagaagaag cgtttgagcg gctgtacacg 2482741 aaagttgtca gctatttaaa ggagcgagat gaactgtttg ttttcgaagg atttgccgga 2482801 gcagacgaga aatacaggct gccgatcact gtcgtaaatg agttcgcatg gcacaattta 2482861 tttgcgcggc agctgtttat ccgtccggaa ggaaatgata agaaaacagt tgagcagccg 2482921 ttcaccattc tttctgctcc gcatttcaaa gcggatccaa aaacagacgg cactcattcc 2482981 gaaacgttta ttattgtctc tttcgaaaag cggacaattt taatcggcgg aactgagtat 2483041 gccggtgaaa tgaagaagtc cattttctcc attatgaatt tcctgctgcc tgaaagagat 2483101 attttatcta tgcactgctc cgccaatgtc ggtgaaaaag gcgatgtcgc ccttttcttc 2483161 ggactgtcag gaacaggaaa gaccaccctg tcggcagatg ctgaccgcaa gctgatcggt 2483221 gacgatgaac atggctggtc tgatacaggc gtctttaata ttgaaggcgg atgctacgct 2483281 aagtgtattc atttaagcga ggaaaaggag ccgcaaatct ttaacgcgat ccgcttcggg 2483341 tctgttctcg aaaatgtcgt tgtggatgaa gatacacgcg aagccaatta tgatgattcc 2483401 ttctatactg aaaacacgcg ggcagcttac ccgattcata tgattaataa catcgtgact 2483461 ccaagcatgg ccggccatcc gtcagccatt gtatttttga cggctgatgc cttcggagtc 2483521 ctgccgccga tcagcaaact aacgaaggag caggcgatgt accatttttt gagcggttac 2483581 acgagtaagc ttgccggaac cgaacgtggt gtcacgtctc ctgaaacgac gttttctaca 2483641 tgcttcggct caccgttcct gccgcttcct gctcacgtct atgctgaaat gctcggcaaa 2483701 aagatcgatg aacacggcgc agacgttttc ttagtcaata ccggatggac cgggggcggc 2483761 tacggcacag gcgaacgaat gaagctttct tacactagag caatggtcaa agcagcgatt 2483821 gaaggcaaat tagaggatgc tgaaatgata actgacgata ttttcggcct gcacattccg 2483881 gcccatgttc ctggcgttcc tgatcatatc cttcagcctg aaaacacgtg gaccaacaag 2483941 gaagaataca aagaaaaagc agtctacctt gcaaatgaat tcaaagagaa ctttaaaaag 2484001 ttcgcacata ccgatgccat cgcccaggca ggcggccctc tcgtataaaa aacaaaagcc 2484061 aagagcaatt atgctcttgg cttgttttaa ttgacggaat gcaaagaagt cagcttgtat 2484121 gtaatgatgg tccggccttc ttcccattga agcttctgca cttcagctgt gcctgacttt 2484181 tcgccaaact ttgttttgcg tacatccatt ggaatctcca tcggatatac tcggtatccg 2484241 tccttctcta acgtgaatat attttcatct atgcgaactt cttttccttt tgtcacaatc 2484301 agtgtattaa attcaacagg cattcccaaa gtgaaatccc ctttcgttct cttttttctt 2484361 tatcataaca tatttcactg tcagcggttt ttcatccatt gtgtgagctg ccgcacgata 2484421 cgccggtttt cttttggcgg gaaataatgt gtgaatgtac tgtagtacca tgtttccacc 2484481 ggcttatgca gttgttttag cttctcttct aataaatagg aatgctgaat cgaaacattt 2484541 tggtcttttt ctccatggat taacagcacg ggagcctgaa ttttgtttac ttggtcaaac 2484601 ggtgtcctcc attgatattc ctcaggcacc tttttcggtg ttccgccgat gactcttttc 2484661 atcattcgcc gcaaatcctg ccgctcctcg tatgtaagaa tcatatcact gacgcctccc 2484721 caggaaacaa atgaagctgc ctgcccgccc atttcgatcg cagtgagcat tcccataatt 2484781 ccgccgcggg aaaaaccgaa gatatggatt ctatccttct tgacatttgg gtgctgctga 2484841 agcaggcgaa aagcagaaaa tgcatcctcc ctgtcttctc cggcaaaatc ctcattgcct 2484901 tctcctcctt gattgcctct gtaaaaagga gcaaacacca caaacccttg ggatgcaaac 2484961 tggataatcc ggcccggccg aaccatgccc acgcttttaa tcccgccgcg caaatataaa 2485021 aatccgtcat attgtcccgg ttccgccggc tcagccagaa gccccttaac ccgtaatcca 2485081 tttgacagat agcagatcgt atacaaacgc acatgctggc ttggcgacgg aaatcttctt 2485141 ttctctacaa tcaaaacagc cgcctccttt tttctatatg ctttccttac tccaaaatta 2485201 catccggaga acctggttag gcattcacac atttttatac ccatcatacg atatgtaaag 2485261 caaaaaagga tattaacttg atgcgaaata aggaggttgt ctatgtgaac agatggttaa 2485321 ggctgggctt cgcctgtgtc ggcagtatct ttctgatgtt cgccctggcg gcttgcaagc 2485381 aggaagaaac gctcaccaaa gtcaaagtag ctgaagtgac ccattcaatt ttttacgcac 2485441 ctttatatgt tgctgagtct aaaggttttt ttaaggaaga agggcttgat gtcgatgtga 2485501 atacgacctg gggcggagat aaaacgatga catcgcttct ttccaacggc tccgacatcg 2485561 cgcttgtcgg gtcagaaaca tctatttatg tcgaagcgca aggggctaaa gatcccgtca 2485621 ttaatttcgc ccagctgact cagacagacg gaacgtttct tgtcgcgaga gaagatgttg 2485681 aacacttcga ctgggatcag ctgaaaggaa aaacgtttct cggtcagcga aaaggcggca 2485741 tgccgcaaat ggtcggcgag tatgtactga acaaacataa gattgacccg cataaggata 2485801 tagacctcat ccagaacata gacttcgcca atattgccaa tgcgtttgct tctggaaccg 2485861 gtgagtatgt acagctcttt gaaccgcagg cttctctctt tgagaaaaaa ggcatcggcc 2485921 atatcgtggc ttcattcgga gaagaatcag gagaggttcc ttatacgact tttatggcga 2485981 aacaaagcta tttgaagaaa aatgaagaca cagccgtcaa gtttacaaaa gccatttata 2486041 aggcgcagca gtgggttgaa aatcattctg cgaaggacat cacagatgcc attaaagatg 2486101 aatttgatga taccgaccca gacgtcatcg aaacatccat tgaacgctat aaaaaacagc 2486161 attcatattc accagaccct ctgcttaacg aaaaagaatg ggagcttctc caaaccatta 2486221 tggataaatc gggagaactg ccgaagcaca ttccatacaa tcagcttgta aataaagaaa 2486281 ttgctgaaaa agtcacctcg gagaaatagg aggcgccatc tatgtctttc ttacatgtcg 2486341 accatgtaac ccatacttat ttttctatta aagaaaaaac aacggctgtg cgggatattc 2486401 atttcgatgc cgaaaaaggc gatttcatct catttctcgg cccaagcggc tgcggaaaaa 2486461 caacattgct ttccattatt gccggtttga ttgagccatc agaaggcaga gttctgattg 2486521 aaggccgtga gccgaatcaa aaagaacata atattggcta tatgcttcag caggattact 2486581 tatttccctg gaaatctatc gaggaaaatg tgcttctcgg tttaaaaatc gccgacacgc 2486641 tgacagaaga aagcaaagcc gctgcactcg gtctattgcc ggagttcggc ctcatagatg 2486701 tggagaaaaa atatccgaaa gaactgtcag gcgggatgcg ccagcgggct gcgcttgcaa 2486761 gaacacttgc gcctaaccct agtctgcttt tgctggatga gccattttcc gcgcttgatt 2486821 ttcagacaaa gctgtctttg gaaaacctgg tattccgcac attaaaggaa tatcaaaaaa 2486881 cagcagtgct tgtcactcat gatatagggg aagcgatagc gatgagcgat acgatctttt 2486941 tattttcaaa tcagccgggc accatccatc agatttttac cattcctaag gaattggccg 2487001 cgatgttgcc ttttgacgcc cgtcaggaac cttccttcca gacactgttt caaacgatat 2487061 ggaaggagct gaattctctt gagaaacagc aaagaaacca ttgatctgct tcacgagcag 2487121 tatcaattca aacagaaaaa ggaaaagtgg aaggtccatt cctttcagct tgccatattt 2487181 attctctttt tctcgggctg ggaaatctcc agcaggcagg gctggatcga tccgctgatc 2487241 ttcagctctc catcagctgt gtggcgatta ttgctggaga aacttggtga cggttcttta 2487301 ctgtcacaca tcggcgtcac tttatttgaa acggtgcttg gctttttgct cgggacgttt 2487361 atgggcacgt gcctagccgc tttgttatgg tggtctaacc gacttgccag aattttagat 2487421 ccgtatcttg tgattttgaa cgcaatgccg aaagtggccc tgggcccgat cctgattgtc 2487481 gcgctcggtc ccagttttat cagcatcatt gcgatgggag ccatcatcag cgtcattatc 2487541 acaaccatcg ttgtctacac cgccttccaa gaggtcgacg aaaactatac gaaagtcatg 2487601 aaaacattcg gcgcaaaaaa gtgggttatt tttaaagaag tcatactgcc tgcatcctcc 2487661 cccgcgatta tttcaacact aaaagtgaac gtcggtttat catgggttgg cgttattgta 2487721 ggggaattcc tcgtttcgaa ggtcggatta ggatatatga ttatttacgg attccaagtc 2487781 ttcaatttta cactcgtctt cttaagcctg ctgatcatcg ccatcttcgc cactctgatg 2487841 tatcagggcg tcgagctgct ggaaaagaaa tggacgaagg ggaggacata aaaaacccgg 2487901 cacatgtgcc gggtttttta ttcaatccat ccagattctt tcagtttttt caagctgatc 2487961 ggaagaacgg aatccttcat aataaagctg aattttttat tgcgggaaag gttctccggc 2488021 agctcgtgaa acaaaaccgg gcctttcgtt tcaaagtaat cagcctgctt ttcaagcttt 2488081 tctatatctg caaaatatat attttttaca atcacttttt cttttccgag aactttatac 2488141 tgtccgagat acttgaggct tttgactctc gcgcccgtct cttcctttac ttcccggagc 2488201 gcagcctctt ctgcgcactc catcggctct actttcccgc ctggaaactc atagcctctg 2488261 tcctcatgtt ctgttaaaag ccatttgccg ccaaaacggc aaatcaccca gacatgcttc 2488321 gggctgtccg agaaaggctg atcgtcaaag gaaagctgaa cagtattctg ataataatct 2488381 ttaaactcgt acatgtttat ccctcaaatc cgttcctagc tatcttccat acatcatacc 2488441 acagttacgt ttcttcggaa gccttttatc aaaaaataag ggaaacccag cacgccgtca 2488501 ggttctgcat gcagactagc tcgtacagtt tttttgcgat acttttgccg gaaagtgcga 2488561 ccgacgctct gggctttatt atgacccgcg aacagggaaa agttacggtt tgcgcttaaa 2488621 tttatttttt aacgtttcta aaagatcgac aagcatctga ggaaccggta tgccaagaga 2488681 gctggctgtc acaacaattt gcacagattc ataaagaata taaaacataa tagccaagtc 2488741 acgaattgat ccctgtgtat tcagcagctg atcaaaaaag tggcatacag agatcagagc 2488801 cagcgtgact aattttttga caagccgggc aaataccttt ttaaatgaca gtttgtgaat 2488861 aatggtttcc ttcaaagtcg tactgataaa ttcaattgcc ataagagaga gcaaaatcag 2488921 aaatgaatac tgaaaacctc caaagaaaaa acccgctgct gaaacgctga ctgctaaaaa 2488981 cgaaaagatg ccaaagtctc tatccattta tcccaacatc ctttcacaga aacggcctta 2489041 cgatattcta tggtaaacaa gccgaacgga ttggattttt cagaaaaatg gactggttgt 2489101 cgcctatttt tcagatacaa aaagaaaagc cggacgtctt ttttaagaca tccggccgtt 2489161 ctatttttga acttaaccta ggtaagcttt tagcatccag ttatgttttt caatattttg 2489221 atggatcgca agaagcatgt cccctgttgt ttcgtcaccg acttcatcag ctaaatccat 2489281 gccgtttttc agctcttccg cgatgactgt gaaatcatca tatacgcttt gaaccatttg 2489341 ttcagctgtt tcatttccag cagcttcttt gacagaagcc gtttctaagg attccttcat 2489401 tgttgcaatc ggttttccgt tcagcgccaa aagacgttct gctaagtcat caatataagt 2489461 tgctgtttcg ttgtacagct cctcaaactt ttcatgaaga gtgaagaaat ctttcccttt 2489521 cacataccag tgataattat gtagtttcac atacatgacc gtccagttgg ctacttgttt 2489581 gttcactgct tgaatcaatt gttctgacat ggtatctcct ccttgttata tgactatgta 2489641 tacccttaat atcgtacgct aaaacctctt ttttaccctt atctgtcacg atttcttcta 2489701 ttatgctaca attgttaaaa aacgggaggt ggaatgtcat gacgcttctc attacgataa 2489761 gtattttgat tgtgctggct gttttgcttg taaccatttg gacgactgta aaagcctata 2489821 atgtaaagca taccattgat ccaccacaag aaaatcactc tgattcacac aatcaatgat 2489881 gatgtgaatg ctcctcttct gactgattgc tggcagcatc ggcgtctccg acttggactt 2489941 ttaaggtcgg catgctatgc tgtttttttg ctgtgacatg agattggaca gtgtatacac 2490001 catcttcctt aaacgtcgtt tccaatcggt atacgccttt ttcttgtttc accttaaaca 2490061 tttggcttgc gtctttttcc ccttctttcc atacttcaaa ctctacttca tcggcatccg 2490121 tcacagcttc atcaccatat gatacagctg cttcataagc agcgctttct ccgggattta 2490181 ctttttcagg cccggtcagc ttgacatcca aaacctcggg cgtctcagct gtatttgctt 2490241 tactttcacc agatccgcat ccattaagca ataaagcaga aaaaagcaga acaaccaaca 2490301 tctttttcat gccatcaccc tttcatcgtt tacctaaata gtagcaaacg cttacagcaa 2490361 atggtacaca aaatatgaga cgtcacaaaa aagacctttt tgcttaagcg caaaaaggtc 2490421 ctttctattt tagccaaata cttttagcaa ttcttcttta tcctgtgaaa gccagaaacg 2490481 cattaaacgt ttagcgcctt ccagatcatg aagcttcgct tggccgcact gcttttcatt 2490541 cgcagcaggt atttctgtaa tctctaccgc ttccttcatt gtgtcttcaa gcagatcaac 2490601 gatttccgct gatgtcggct ctccgctcac aactagataa tagcctgtct ggcagcccat 2490661 tggagaaata tcaatgatat caaaatgatc gtatttctca gcgtgagaac gaatcgtaaa 2490721 cgcgagcaaa tgctcgagtg tgtgaatggt gtcaggcttc atcgcctgtt tatttggctg 2490781 gcaaaaacga atgtcaaatt tatttacaac gccgtctgtt cccactttat gcacgccgca 2490841 atgtcttaca tatggagcaa caaccgcatt atgatcaagc tcaaaacttt ctactgaagg 2490901 cataatggca ctctcccctt ttttaaaaat gtaatttcat tataacatac ttttccgata 2490961 agaattattg attaactttt caatctgtgt tttttttctt atacttgcat cagaaaggtt 2491021 gctgaagaaa catgaaaacc ctattcatcg ctctgatcag aggatatcaa aaattcatct 2491081 cgcccctgac accgccaacg tgccgctttt atccgacctg ttcccaatat ggaatcgaag 2491141 cgattaaaac acatggcgct ttaaaaggcg gatggctgac aatcaaacgg attttgaaat 2491201 gccacccgtt ccatccggga ggagtcgatc ccgttcctga aaagaaacaa aaacattaat 2491261 tgttataacc gtttacgata agatccagtt ttccggtttt aggatcaatg actaagccat 2491321 ggaccggaac gttttcaggg aacagcgggt gatgtttaat aacatctacg ctgtctttca 2491381 cactcgcttc cactgaatca aagcttttaa accattgatc aaagtctaca ccggagtact 2491441 ttattgtttc gatgcgttct tccggaatcc ctcttgcttt gattttttca agcatgcttt 2491501 tgctgctgat tttgctcatg ccgcaatcgt gatgcccgat cacacacacc tcatctgcat 2491561 tcagctcgta cactgcgacg agtatacttc tcatgatgct tccgaatggg tgtgtcacaa 2491621 gcgcaccggc acttttaatg attttcacat caccgtttcg caaattcatc gcatgcggca 2491681 gcagttcaac cagacgagta tccatgcaag aaagaatcgc cattttttta tctggaaatt 2491741 ttgatgtttg atacttttca tactctcttt gttcagtaaa tgtcttgtta aattcgagaa 2491801 tatcatttag aagactcatg ttcgttgtcc ctttctattc tttttactct tcaatatatc 2491861 acaacccttg tttattcgtc ataataaaaa aagacaaacc ctcaggcctg ccttatttcc 2491921 ccatgttata gcgttttttg aactgctcaa ctcgtccgcc tttttcattg aatttctggc 2491981 ggcctgtata aaacggatgc gtgtcagagc ttacctctac tttaatgaca ggatatgtgt 2492041 ttccgtcctc ccactctgct gtttcattag atgttttcgt agaggtgctt agaaaacggt 2492101 agccgctgtt gacatcctga aatatcactt tgtggttctt tggatgaatt ccttctttca 2492161 tgggtatctc ctttcaataa atcgtaataa ttacgtttta ttttataacc ttacaaacgt 2492221 tttgtcaatc ttcttatatc cttccctctg tttcacatcg taaacctcat ggcatttaag 2492281 aataggaaga ataatctaac cgaggaagca aataataaac ccaaaataca tacagaacgt 2492341 ctttttggaa aggtggttta cgattgtgga tgatttagtt ttggccagaa gcctttttgg 2492401 cacgacgatg ggctttcata tcattttcgc aacacttgga gtcggtctgc cgctcatgat 2492461 tttagtggcg gaattgatct atcaaaaaac gaaagatgac cattatgcga tcatggcgaa 2492521 aagatggacg aaagcacaag ccgttttgct gggggtcgcc ataccgaccg gaacgatcgc 2492581 gggcactcag ctcgcgcttt tatggccggg atttatggaa gtcatcggcc gggtgatgtc 2492641 cctgccattt caaattgaaa tctatgcttt ttttgttgaa gccctattca tgtcgattta 2492701 tgtatacgct gcagaccgtt tgtcacctgc aatgaggatt gttgctgttt tctttgtgtt 2492761 agtcggggca gcagcatccg ctgttctgat cacgaatgtt cacgcttttg aaggtacgcc 2492821 cgccggtttt aaaattttaa acggaaaaat tacagatgtt gacccgtggg ctgcgttttt 2492881 taatcctagc ttttttatca ctgccggcca tgtcgtgctg tccgcgttta tgactggtgc 2492941 gtttatcgtg gcttctgttg cggcgtataa aatgatccga acgaggaaaa aggaaagggt 2493001 ctatcgcttt caccggaaag cccttttgct cgcactgacg atcggcggta ttttttcatt 2493061 gctgaccgct ttgaacggac acgaatctgc acagatgctg tacgaatacc agcccgaaaa 2493121 attagccggt gcggaaggcc tatttgaaac aagatcccac gccccgctcg ctatcggcgg 2493181 ttttaccgac ccgaatgaag aaaaagtaaa atgggcaatc gagattccat gggctttaag 2493241 ctttttggca gcgaaccgtt ttgacactgt tgtaaaagga ttaaatgcat ttccgagaga 2493301 tgaatggccg ccgcttttca ttcacacgct gtttaatgcg atggttggtg taggcatgct 2493361 gctaattctt tattccatta tcggtgtggt ctggagaaag gtgctcaaga aagaccgttt 2493421 cccaacgtgg cttttgatca ttttcatgac agcaggccct tttagtctca tcggcattga 2493481 attcggctgg attttcgcat gtacggggag gcagccttgg gtcatctatc atctgctgaa 2493541 aacgtcagat gtcgtaacaa cgactggctc gatcggggtg ctgttcttat ttttcacatt 2493601 tgtttatgcc gtgttaggcg cagctgtcgt ctacgtgctg ctgtattatt tccgcaagca 2493661 cccggttgac gaagatttaa atacagcgga gtcgtaatgg ctccgcaaac aggaaaccaa 2493721 atggaaggaa gatcgtacaa atggagattt caactgacgc tctgatcgcc atctcaatta 2493781 tctggggctt tgtgtttatt tacgccgtca tggcgacaat ggattttgga gcgggatttt 2493841 ggtctatgat ctatttaaac aaggagcata tgaaggccac cgatattgcg aatcgctttt 2493901 tgtccccgac ttgggaggtc acaaacgtct ttattgtggc catcgtcgtg gcgcttttca 2493961 gttttttccc cggcgcgaca tttgtgctcg gcaccgtttt attaattccc ggaagcatga 2494021 ttttgctgct tttagcaatt cgaagcggat ttctcgtgtt ttcaaataca gcaaaggagc 2494081 ggaaaacgct aagatatatt tccggcatct ccggctttat cattcctgct attttaattt 2494141 tggtgcttcc tgtgacacac ggagggttta tagaaaaaac ggatggaatc tataacttaa 2494201 atatgtctaa aatcttttca agccccaacg cctattcatt tatcgggttt gcgattttaa 2494261 gcaccttatt tttgtcctcg ctgttgcttg cagatttttc aaatgtggca gaggaacagg 2494321 atgcgtaccg agcctacaga aaaagcgccc tgattaccgg cccgatttca ctgttgtttg 2494381 ctgtatgcat tatggtaact atgcggaatg aagcaaactg gctgtacagc ggaatgatga 2494441 atgatttttc ttggattatt gcatcgttca ttacatttgt cattgctgga atcgctcttt 2494501 ttctgcctaa caaaagcttt ggtcaaaaca tcggaaaacc gcgtctcgca cttgttgcga 2494561 ttgggataca gtattttctc gcaagctacg cgtacgggcg ggcgcatctt ccgtatatga 2494621 tttatcccga tgtgacagtc atgtcaggct tcacagagcc agcaacgttc agagcgctgt 2494681 ttgcaacgta tatcgttgca tttatcattc tatttccggg cttctttttc ttctggaaaa 2494741 tgtttatgcg agataaacgc tatatccgcc aggaggaata gagggcaagc cagccggcta 2494801 tactaatcca gaacctttat aaggagggga tggcatggag cagaaaattc tatgtgaggt 2494861 caacaactgt tcttattggg gcaaaggtaa caaatgcacc gctgatgcca tttatgttgt 2494921 cagccatact ggtgaaacgg ctgaaaacag ccgggaaaca gactgcaaaa cgtttaagcc 2494981 gcatgattta taattaaaag aaagagctgc atcagccagc tctttctttt tgcatgttga 2495041 gtgttctcag ctttttagtt atgaccccgt ttgcaggtga aaacaaaaag gcgcttgcat 2495101 aacatacacc tgtcatggcc gccatcgctc ctgaaatcga aacattaagc cacgttgcga 2495161 agaaatagcc catgaccgcc gacagcccgc caatcaacgc gctgagaatc agcatataaa 2495221 gaagccggtc tgtcagcaaa tgtgccgcag ccggcggaac aatcagcatg gccacaacca 2495281 atacggcacc caccgaatca aaggaagcaa cagtcgtcaa ggacagcatg cccatttgca 2495341 cgtaatgaat gagcaaaacc ggtattccca aggctaaagc catttgagga tcaaacgaag 2495401 cgattttaaa ctccttatag cacacactga tcaacactac gtttaaaacc agaacagatg 2495461 ccagcatcca aaacgctttc ggcccaatat caaccccgaa taccgtcacc gtattccacg 2495521 gcacaaaagc gatttctccc attaacgagt gctcaatatc gagatggaca ttcgctccat 2495581 acacagaaag caaaataacc ccgattgcaa ataaggatgt aaacacaact cctatggcag 2495641 catctgattg aacccccttg ctatgaagaa gctgaaccaa gaaagccgtt aacagaccgg 2495701 ttgcggctgc gccaataaac atataaatcc catcgagact tcccgtcact agaaaagcgc 2495761 cgacaatgcc aagcaacact gtgtgactga ttgcgtcggc cagcatcgcc atgcttctca 2495821 gcacaagaaa tgtgccgatc aatccgcagc ttacaccgac taatacaccg gtagctataa 2495881 tccatgcttc aaaactcatt tgcgatctgt cccttctcgg catcatgaga cgcttttcga 2495941 cgctcaggca tccgtccata cagctttaag agtgaataaa gccgctctct cgtttctctc 2496001 ggtaaacggt ccgggtcaaa gtagtcctga tcggattcta tattggcaag ttccatttca 2496061 tgcatgagat acacttcata catccgctgc ttcaaagctg tgtgatagcc tttttctatc 2496121 cctttgcttg tgatttgcca aatcccattt tcgatacgct caatgcacct ctcttgttcc 2496181 aagtcattta atgccttaag gcataatgaa ggggataggc gtcttttctt tcttacactt 2496241 tcaacagtta cacaaagatt attcttttca tactgttcat aaatcgccaa aagcacttgc 2496301 tccctgcttg ttctgcgccg cagcctcatc agccttatgg ctttagcagc caatccccgc 2496361 ttaggcgcgc aaatcattga aaaaagaaag agcagcgttg cagataagat cattaatggc 2496421 cctgtcgcca ttcccttcat cgtggtgcta agcagggttc cggccactcc gctgaccccg 2496481 cctgtaatcc cggcaatgat gatcatcccg gttaatcgtt cggtccaata tctcgcggtt 2496541 atggcaggtg taatcagcat agccgccatt aatatcacac caacagtctg aagcccaatg 2496601 acgacagcac agacaatcag acaagccaaa agcccgttta aaaaacgcac cgggattcct 2496661 aatccctttg caaacgcgag atcaaaagta atcaatgtaa attccttaaa gaaaacaata 2496721 cataggagca gtagaacagc ggatatccct gcaataagga tgatatcctg cctgaccaat 2496781 gaagcagcct ggccgaataa aaaagaatca agcccgcttt ggcttcccgc cccctgttgc 2496841 tgaatatatg tcagcagaat gatcccgacg ccaaaaaaca cagaaagaac aatcccgatc 2496901 gccgagtcct cctttgtttt tgaaagccga ggaatcagct gaatacaaaa cgttccgagc 2496961 agtccggcga gcgctgcccc cagcaaaaag aaaggcagtg atttttgccc ggtgaacaga 2497021 aaagcgagac acactcccgg cagagctgaa tgggccatcg catcgccgat taaactttgc 2497081 tttctcagca gcacaaagct gcccaaaaca ccgcttgccg tcccgagcaa aagcgtaccg 2497141 gccagcaccc actgtgtatt cggatgctga agctgcagcc acaaactttc aaacattgcg 2497201 ctcactcctt atgtccttct gccagcactt tatcttttaa aaacgtaagc cttcctccat 2497261 atgttttttg caggttttcg atcgtaaaaa cgttttccgt cggtccgaaa gcgattttcc 2497321 ttaaatgaag cagtaagatc caatcgaaat aatcctcggc ggtctgcaga tcatgatgga 2497381 cgacaagcac ggtttttcct ttttctttga gttctgccaa cagcgtcata atcgcgcgct 2497441 ccgtcgctgc atcaacacct gcaaacggtt catccataaa ataaatgtca gcgttctggc 2497501 agagtgcccg ggcaagaaac acccgctgct gctgtccgcc tgacagctgg ctgatttgcc 2497561 ttttcgcata atcatgcatc ccgacttttg ttaatgcggc cttcgccatc tccacatccg 2497621 ctttctttgg cctctttaat aaaccgattc tcccgtatct tcccattagg acgacatcga 2497681 gcgggcttgt ggggaaatcc cagtcaaccg agccgcgctg cggaacatat ccgattctgg 2497741 tccgctgatc cttatagtct ttgccgtaaa tagagatgtc tccggaagct ctgggcacaa 2497801 gaccgagaat cgttttgatc aaggttgatt ttcccgcgcc gtttgggccg ataatgccaa 2497861 taagttttcc ttcaggcacc tgcagcgaaa tgtcctgcag tacaggcttt ttatgataag 2497921 caaccgtcac attatcaagc tcaacaggga acatatcctc cacctctttt ctttatttaa 2497981 gcgctttagt aatcgtgttg atattgtggc ggaacattcc ttcgtatgtg ccttcttttg 2498041 tgcccttttc acccatggca tccgaataaa gctgaccgcc gattgtgact gtatggcctt 2498101 tttctttagc gccttccacc actgcattga ttgatttttc agatacactg ctttctacga 2498161 acacagcttt tatttgtttt tctgtcagaa gatcaaccag ctcctgaaca tcccttaatc 2498221 catagtccga atctgtgctg agtccctgca ggccttttac cttaaatcca tactcattcc 2498281 caaagtacgc aaacgcatca tgagcagtca caagcacacg gcttttctcc ggaatatgtg 2498341 cgatctcctt acgcgaccac ttatctaaat attgcaaatc ttctttgtac tctttggcat 2498401 ttttccgaaa ggcatctgcg tgctgaggca ttgctttgct gaattgcgct tcaatttcat 2498461 ccaccgcata gatccataac ggaatgctga accagacgtg gggatcaaac gtcttgcctt 2498521 cccccgcggg aataagctta tttttcggaa tggcctcagc tactgccgcc gattgttttt 2498581 gttcgccgat tttttggagg acatcctcca ttttcccttc caaatgcaac ccgctgtaca 2498641 gaacaacatc ggcagacatt aattttttcg tgtcaccttg ggaagctttg taaaggtgcg 2498701 gatcaacccc cggtcccatt aaagaggtga cttttacgtg cttacctccg atgttttctg 2498761 ctgcatcggc aatttgagat gttgtcgctg tcacttgtaa ttgctgatca gcgctttttc 2498821 cggctgaatc cgttccgcat cccgttaaag caaaggtcgc aaaaagtact gctgccatca 2498881 gcccttgtct catatttctc ctcctctttg ccatcaatgt ccgattgttt tatcttatgt 2498941 tgtcagttct tagacatgtg acattaaatt agccaaaagc atgttttatt tacacaggac 2499001 aaaaagtttc cctcatgcaa aattatcgcg tttggccatt tttgtcaagc tgatttacat 2499061 aaaaaaaccg gctgggtcag cagccggtcc aaacgagaag ggatgtattc aacgaacact 2499121 tttactgtaa cagcacagtg tcatttattc aaaatagcaa aatgcttttt tcttaaccat 2499181 gctgtgtgaa aacatccatt ttggtcacat attttcgcat aatatcttgg tttacctcaa 2499241 cccctaaacc aggctgtttt gacacagaaa taaatccatt atcaatacga atatcaggag 2499301 ttacaatatc ttcatcccaa tagcgtgagg atgaagatat atcgccaggt attgtgaatt 2499361 gaggcagtga agcaagcgcc acgttctgcg ctcttgatat gcctgtttcc agcattcctc 2499421 cgcaccaaac ctgcatatga tgctctttgc ataaatcatg aatttttaag gcttctgtta 2499481 agccgccgac acgagaaggt tttatattaa taattttgca gcttcctagc tcaatcgccc 2499541 gtctcgcatc atcaactgaa caaatgctct catcaaggca aatggccgtt ttcaaatgtt 2499601 tctgcaagtg gcggtggtca acgatatcgt cagcttggag cggctgctca atcatcatta 2499661 aatgatagtc atcaagctcc tttaaacggc tgatatcctt cagttcgtaa gaggaattgg 2499721 catcggccat aagcgggatg gttgggaatc ggctgcggat ggccttgacc aattccacat 2499781 cctgcccagg ctgaatttta atttttattc tttgataacc ttctttttga tagctctcaa 2499841 tttccttcag catatcgtca agaggcgcca ggccgactac caccccggca gggactttat 2499901 ctcttgttcc gcccaatgcc tcagcaaggg atacgccctt ctttttggca taaatatccc 2499961 atacagccga ttcaagtccc gcttttgcca tccggtttcc tttataccgc gccaggctgt 2500021 ccggcacttc tgaagggtga ttgaattcac ggccgacgac atttgggata aaaaaatctt 2500081 ttagcatatg caaacatgtt ccaatggttt cctcggtgta ccaaggcgaa gagaaagcgg 2500141 aaacttctcc ccagcctgtg acacctgatg tatcaatggc ttccacgatc agaaatttac 2500201 gctcttgaag cgtttcgata ctgtttttaa acggtttctt taagttcatg ctcaaatggt 2500261 aaagcgtgat tttttctatt tcgatcatag cagttctcct ttacgcgcat ccttcagctg 2500321 atttcgcaag agcttattag acgcattgcg cggcaggcgg tcaagcacaa agaattttgc 2500381 cggaatttta tacttcgcca agcgttcttt gcagtagtca gtcaattctc ctgcgctcac 2500441 aggcttgtga aggacaagat aggcgtgagg cactttcccc cattttttgt cctcagcccc 2500501 tgaaaccccg gcttcggcca cagcggggtg tgaaagcagc actgactcca cttcggccgg 2500561 ataaatgttt tctccgccgg atatgatcag atctgaacgt ctgtctaata catataaaaa 2500621 gccttcattg tccaaataac caagatcacc tgttttcagc cagccatttt gaaaggaggc 2500681 ttcgtttgcg ctctcccggt taaaatagct tttcatgaca ttcgggcctt tgaccatgat 2500741 ttcaccgtgt tcatacggtt cacatacctg tccgtcccgc tctattttga tttcacacga 2500801 aaacagcggt ttccccgcag atccgagctt ttccatgctg aattccggcg acagggtaac 2500861 aatttgcgag catgtttctg tcattccata tgactgaaag acagggaatc ctttctcacg 2500921 gcattcctca agcaatggca gcggtgcagg accgccgccg agaagaatgc atctgatgga 2500981 ttcagggcag cggtttgttt cttccaaaag actggccagc atagtctgca ccgcagatat 2501041 cattgtcact tcatgcctgt tgatagaatg cagcacatcg cttacggaaa aacgctggtg 2501101 aagcacgaca gtcattccat agatcacaga tttaaataat gcggacaatc cgctgatatg 2501161 aaagagcggc aatgcgataa gccagcggtc ttgttctgtt atacccaaat taagagcgga 2501221 cgacaccgca ctgaaataat ggtttccgaa cgtttgctga actcccttgg gctttcctgt 2501281 cgtacccgac gtatacatca gcgttgccgt tgcatccatt tgcatataag cctcgatctc 2501341 aatttcctct gctgcttctt tcatcagttc atccacatca atcgtttgaa cgatgtgttc 2501401 atattctttc ttctcaaagc ttgaatctgt caataaaaag ccggatcccg aatcctccag 2501461 ctgaaacagc ctttcatgtg ttgacagctt cgtattcaaa agcaccgcct taacaccaag 2501521 caaaaaacaa gcgtgaacag cgtataccat ttctgcacgg ttttggagca aaatagctgc 2501581 agtatcccct ttccgaaccg aatgagcggc aagctgttcc gccattcgtt tagacgcggc 2501641 aaacaattct gcaaatgtca cggtttggtc ttcatagatg agagcgattc tctcaggtgt 2501701 cagctgtgcc cgctgcatga gccagttggg ctgttctgtc agcatgtcat catctccgag 2501761 gtaaaatgtc tgtattgaaa agaaaacagc ttggaccgca aagtctcaag ctgttggttt 2501821 actagatatt gctgatcacg gaaaacgagg gaactgtccg aaatcaggtt tgcgtttttc 2501881 cttaaaggaa tcacggcctt cttttgcttc atctgttgtg tagtaaagaa gggtagcatc 2501941 ccctgcaaac tgctgaattc cagcaagtcc gtctgtgtcc gcgttaaacg cagctttaag 2502001 aaagcgcagt gcggtcgggc ttttttcaag catttcttca caccatttaa tcgtttcttc 2502061 ttcaagctgt tccaaaggaa cgactgtgtt gacaagaccc atgtccagtg cttcctgtgc 2502121 gttgtactga cggcataggt accagatttc acgtgctttt ttatgtccta caattcgagc 2502181 caggtagcca gaaccgtaac ctgcatcgaa gcttcccact ttagggcctg tttgtccaaa 2502241 aattgcgttg tccgcagcaa ttgtcaagtc acatacgatg tgaagcacat ggcctccgcc 2502301 gatcgcatat ccggacacca tcgcaacaac cggtttcggg atgacgcgga ttaaacgctg 2502361 aagatccaat acgttaagac gagggatctg gtcgtctcct acatatccac cgtggccgcg 2502421 cactttttgg tctccgccag aacaaaatgc tttgtcccct gcaccggcaa gcacgataac 2502481 cccaacgttt tggtcgtctc ttgcgtcagc aaacgcatca atcatttcag caaccgtttt 2502541 aggggtaaac gcattatgta cctcaggtcg gttgattgtt atttttgcaa tgccattata 2502601 cgtttcatac aatatctcat cgtatgtccg ttttgttttc cattcagcca tatgatgacc 2502661 tccttttatt ctctatgtga atgagtcaga tgcttgtcaa aaactcactc actattttac 2502721 caaacaatcg cggctgctcc acatggaccg tatgtcctgc ttttggaaca atctctattc 2502781 tactagaagg aagcatctta tgcacctctt gattgatggc gcaaaatttt tcgtcccact 2502841 ccccgcagat cagaagcaca ggaacatcta tttcctctac acggctccac aaggaaggct 2502901 gtgaaccggt gcccatgccg gttaaactgt tcgcaagccc aatcttattg ttccgcagac 2502961 ggcccgatcg tatcctgtac cgaatatctt cagccagcct ctgctgagat gaaaacaaag 2503021 ggatattctc ccaatacgca acaaacgctt cgagcccgtc tcgtaaaata aaatcagcaa 2503081 gcttccggtc ccgcatgatt cgttcccgcc gttccccaag tgttttgagc cccggcgtcg 2503141 tgctttcaag cacaagtgcc gatacccgct cgggatatgt catcgcaaaa gagtaagcaa 2503201 gccttcctcc catagaatac ccaatcaatt tcactttgtg aagttttaat tgatcaaaaa 2503261 tctcggcaag gtcagaaact tgccgggttg tgctgtatct tttcccattc agcggggcat 2503321 cggtttcccc atgccctaaa caatcaattt tgatcaaacg ggaatcaggc agcatttcat 2503381 caagaaaagt ccatgattgt ttgctgccgg taaacccatg cagacagacg acggcttcgg 2503441 aagcattcgg tccctcgtct gccactgcat atcggacacc atctgatacc gttatgttta 2503501 cagttcccat tgttttttca cttcccgcac agcctcattc agcatatcgc gatgaagctg 2503561 gactcttgat tggcgatccg ttttgatttc aatcaaatgg agtccgggct tgtctgcctg 2503621 cggcgcgtaa gctgttttga attcatccca agaagccggg catgaatacg ttccgccgta 2503681 aagtgcagcc gcatgcttga aatcgagccc tgtcggtgtg ccgaacaaat cttcaaagtg 2503741 tgtcttctca gaagcctgcg gcaaaaagga gaaaatccct cctccgtcat tattgacaag 2503801 aatcacagta agaggaatac ccagcttttt ggccgccagc aggccgttta aatcatgata 2503861 aaaagataaa tctccaatca caagggtaac aggcgctttt gttccttcac atacccccat 2503921 ggcagaggag acgacaccgt ctatcccgtt tgctccccgg tttgaataaa tccggaaagg 2503981 gcggtcctgc ttttcaaaaa acgtatcaac atccctgatc ggcatgctgt ttcccacaaa 2504041 cagcgagctg ttttcaggca caagatgctg aaggattcga tagagattgc cttcaaacga 2504101 aacatcttca ctgctgattg tttgcagatg ctcgcggaac cgcccattga caaactgcca 2504161 cttttccagc cactctgagg atctggtggc agcagtaagg cctgccatga tctcctcagc 2504221 aaaaacagac gcattacaat gaatcatatg cgcgcttgcc tgtgtcgggt ctctccaccc 2504281 tccatcctcg tcaatcacga tttgctgaat cgtcggatca tccttaagcc ataagaaaac 2504341 cggttttgaa acaggcatcg gtccaaaccg aatgacaaca tcaggacgga gtttccgctt 2504401 cagctcatca tcttttaaaa acgaatcata cgcatcaata acagtgcttt tatcatgaac 2504461 accattccgc agattagaca gcggatctgc taaaattgga tactgaagcg cttttgacag 2504521 cgcaataatg ttttccttgt ccgcatcact atggagctct ccgcagacga tcattccttt 2504581 ttcagcctct gcgagcatct cagccacatc agacagggac tctcggtcaa cagactgcgt 2504641 acccgttttc acagacacat gacggcctgt tctcattctt ccaaacggct catctgaaag 2504701 atccggcatc agcggttcgc gcagcggcac attcacatgg acaggcccca tcgggcgctt 2504761 ttgtgcttct ccggcagcgc ggcttgccag cgttcggatg tatctcagca tttgcggaga 2504821 ctcttcagga agagcagagt ctgtgaaaaa cttaacaaag ttaccgaata agaagtgctg 2504881 attaatagcc tgcggtgcgc ctacttcgcg cagctcatga ggccgatcag cagttaacac 2504941 aataataggc acccttgaat aatgggcttc aaccacagcc ggataaaagt tggccgcggc 2505001 tgttccagat gtacagatca atagtacggg acgctgcttc gcttttgcca aacctaatgc 2505061 aaaaaatccg gcagaccttt catcaatttg gacatggacg ctgatatcgg gatgcgcagc 2505121 acaaagaaca gccagcggtg tagatcttga gcccggacaa acgacggcgt ccgtaattcc 2505181 ggaaagggcg aattcatcaa taaaacttcc gatgtaatga gtaatcgggt tgactgtcaa 2505241 cgcctctcac ctcctaatgc agagatcatc ggcttcaatt taatctgtgt ttcttcatat 2505301 tccgagattg gttccgagtc ttccacaata ccgcacccgg caaacagcct tgctgtgctt 2505361 ccttcgatga gccctgaacg aatggcgacc gcgaattccc cgttatcctg gctgtcaatc 2505421 cagccgatag gggccgcata ccagccgcgg gacatcggtt caatctccct gatcacgtca 2505481 acagcttttt cctgaggtga tcccccaagc gcgggagtgg ggtgcagctt ctcaattaag 2505541 tcaaaaatcg aagcagactc gcgcagctgt ccgacaatcg gcgtaaacag gtgctgaacg 2505601 ctttttgttt tgtacaaaac aggtccatca ggcttttcaa cctctgaaca gcttgataca 2505661 aaagcattat gaatcatacc taccacaata tcatgctcaa gcaggttttt ctcatcgttt 2505721 aataattcaa ggcctatccg gcggtcgtct tcttcattca cgcctcgttt aatggagcct 2505781 gccagacagg aagacatgac agtgccgccg tctcttttga tcagtctttc cggagacgcg 2505841 ccgacaaagg ttttgccttc ttgttcaatt gcaaaaacat agcttgtctg ctgatcgtcc 2505901 agaagcgttt taagcaccgg ttcaatttgg attggaccgt caaacgtgag cagcagctct 2505961 cgggcaagaa caaccttatc atattgtttc tctttaattt ggcttgtggc cgtttcgatt 2506021 gctttcagcc aatcatcctt atccagctct tcggctgctg caatcacagc ctgatcttct 2506081 tgcttgaaat cgggaaccat aaattccgcc gcaaaagctt ttaagccttc taaaacagct 2506141 tctgcgtctt ctcctccgct tacccatctg ttaactgtta agaacgggcc ttcagcagtc 2506201 atcgtcagca taagcgcagg cacaaagaaa tccccttccg agaaatggtc ccattgtgaa 2506261 cctctttctt cgcaagggtc aaaagaaaat cctccgaata acacaggtcc cactgcagaa 2506321 tgctgcagct tttcttcttc ataaatatga aaagccgtct ttttaaagcg ctcccattgt 2506381 tcaaaaacct cacgataccg ctcgctgttt ttttgatttg tctggaaaac cgcttctttg 2506441 ccaagaccga ctattgtcaa ttcactttca ggatctgacc aaaaaaatcg attgcctgta 2506501 tatttttttg ctccgtaatt gaaaaatgat agagggtcaa gagactcgat ttgtctcgaa 2506561 tagcttatta agacagcatg gttgacttct ttggctttat gtaatgcatg tagaacttcc 2506621 tttcggaacg tacgctgcac cgttgtcacc atgagacatt cctccataat ccttaaaatg 2506681 cttttaatac catacacctg tgtctccttt gtgtcaaaca cagatcatgc agtccaaatg 2506741 gcctgcctta cctattataa acctaatttc agaaatgaaa aagaaacaaa gcttaaattt 2506801 ctttctccac tgatagcaaa ggttgtatcc gcttaccata aaaggaaaac ctcctatatt 2506861 cctccacccg ccatttatga aagttctcag gcgatctgtt catactaaag gtatgcatca 2506921 cagagaaacg aggcgatcac attgcttacg aaagaacagc ttcagcattt aaaaaatgaa 2506981 ctggaacaaa cgaaaaaaga tatcttaaac cgtttcaaag acaatgatca ttttcagctt 2507041 aactcagcct ttccttatga ttcgtggggt gagctttcgg catacgacaa ccatcccggc 2507101 gatcaggcga cagaacttta cgagcgtgag aaagacatcg ctctagactt gcatgagaga 2507161 gagcaccttc gggacattga gcattcattg aaggcgatag aaaacggtac gtatggcatt 2507221 tgtgaagtca gcggaaagga aatccctttc gaacgacttg aagcgcttcc gactgccaca 2507281 accctcgcgg agtattcgtc acaggacgtg gtttccaaag accgtccgat tgaagaagaa 2507341 acaccattcg ggcaatttga atttgatgat gatgaagaaa tcagagcgcc atatgacagt 2507401 gaggattcct atcaggatgt cgaaaaatat gggaactcac aaacgccgca ggatatggaa 2507461 aaccctccgc tcagctatga tgatatgacg atgaatgccg aagagaatat cggcaatacg 2507521 gagtcttacg aaaatttcat cgctacagat atcactggga aagaaattac cgtttatcaa 2507581 agcagagccc atgagcgcta tgaagaagaa cttgacgaag agggaatcat gaccacattc 2507641 ggcgatctcc acgctgattg aacccccaat tattgggggt tcttttccgt tttcagcata 2507701 tcgtaaatca gcttcagata atccttttgc aggccgatgt cataccgctc gccctctagc 2507761 aatttcccgt atacggtaca tgccccgagc gaagctttta tcgcatccgt tacctgcact 2507821 tctcctccgc tatcagcttc taatgcctcc agctcattaa aaatatccgg tgtgaaaata 2507881 taacgccctg ctgcggcaaa atgagacgga gggttttgtt taggcttttc cacaatatcc 2507941 tgtatgcgat aaagcccttt ttcaacaggc tcccctttta tcaccccgta atgatgtaaa 2508001 tcctccgttt ttgtttcttt taagccgatc acactggact gatatttcgt atacgcttca 2508061 atcagctgcc ccaaagccgg ctgattggcg gaaaaaatca gatcatctgg caaaacgacg 2508121 gcaaaaggct ctcctcctgc aaattgcttt ccgaaagaaa tggcgtcgcc aagacccttt 2508181 gcataaggct gccgcacata gtgaatccgt atatccggaa tgggatgctc tctaagtaaa 2508241 tgcagtttat tcttagaggc caaaaaagcc tcaagtgcca aagaggaatc aaaatagtcg 2508301 acaatcagat ttttatggct cgatacaacc atcaaaatgt cctcaatgcc tgactccttt 2508361 aattcttcaa caagataatg aatcacaggc ttagatccta ccggaaacat ttctttcgga 2508421 atcaccttcg tcaccggcag atttctcgtg ccgaatccgc ctgcaggaat gatcgctttt 2508481 tttatcatgg tattttcccc tcagctcatg tttattacat gatattccaa gagcgcatcc 2508541 cgatgtttgt acatctgaaa ttaggcggaa gcaactgggc agaaagcgga atcacgaacc 2508601 agcccttttt taataggata ttgatatatg accagtaatc ttgtaaagga gctcaggtga 2508661 tgaaaatttg tgtggttggc gccgggtatg tcggtttaac cctatcagcg gcactggcat 2508721 ccatcggaca tgacatgata tgcacagaca aagacgtcaa aaaaatcggg cagctgaaaa 2508781 aaggagtcat tcccttttac gagcctgggc tttcagatgc aatacttcgt tgcggcaatc 2508841 tctcgttttc ttctgaagtg aaatcgagca tggaggaatg tcccgttatt tttatcgcag 2508901 tcggaactcc gccgcgttcg gacggatcag ctgatacgaa agccctgcag tccgtcatcg 2508961 gtgatttaag cgaggcgatc cgatcgtata aaaccattat tacgaaaagc actgttccgc 2509021 ccgggacaaa tgaaaacata gcaaaacagc tgattgcctc cggagtgtct aaaaacctct 2509081 ttaatatcgt atccaatccg gagtttctgc gggaaggcaa tgccttatat gacatgctgc 2509141 atcctgacaa aacagtcatc ggtgttcagg aagaagatca cgtatcggca gccatcgtca 2509201 aatccattta caaacacatt gatacccctt ttatcgttac aagcttagcg ggagcagagc 2509261 tgatcaaata tgccaacaat ttctttttag cggccaaaat ttcgttcatt aacgaaatgg 2509321 cccgcatatg tgaagcctat caatcagata tctcagatat ttcccgcgct atcggtctag 2509381 acccaaggat cgggaagcac tttttgcagg caggcatcgg atacggaggc tcttgttttc 2509441 caaaggatct gcaggcgctg caatttgctg cccaggaaaa aaacacggag accttcctgc 2509501 tccgggccgt gcagcacatt aatgacaccc agcttggcct gtatatcaaa aaaatacagt 2509561 cattcttcga aacacttcaa ggcaagaaag cggctgtact cggcatttcc ttcaaaccga 2509621 atactgatga catccggaat tctcaggctg tcagactgat ggaaaggctg gcggagctgg 2509681 gatgtgatgt tcatgcatat gatcctgaag ctgtacttcc agaacatttg cggcaacatg 2509741 taactcagca ttctcaagct tttgatgcga tcgaagagag tgacttttta tttttggcga 2509801 cagaatggtc tgagttttta gcgtttgatt ggaaaaaggc tgcagatatc atgaaagggc 2509861 gtcttgtgat tgacggacgc aacgtactaa aaaaagaact gatcgaggct tgcggcctga 2509921 tctgtacggg agttggccgt ccatgaaaat actcgtcaca ggagcagcgg gctttatcgg 2509981 ctcccacctc tgcgaagaat tactaaaaga taagaaacat aacgttatcg gaatcgatga 2510041 ctttatcggt cctactccat tttccttgaa attaaaaaac cttaaaaacc tgctgccgga 2510101 aaagcgattt acgttcataa aggaaaatct gctgacagcc gatcttgctt ccttactgga 2510161 aggagtggac gtcatctttc atttggcggc cataccgggt gtccgctcaa gctggggcaa 2510221 tcattttcac ccatatgccg cacataatat ccaagcgctc caaaggctcc tcgaggcgtg 2510281 ccgggaacat tctattcaaa cgttcgtctt tgcatccacc tcttccgtct atggcgaaaa 2510341 acaaggaaaa gtcagcgaaa acacgtcgct ttctccttta tctccgtacg gggtaacaaa 2510401 gcttacggga gaaaagcttt gccatgtgta taaacagagc tttggcattc caattgtgat 2510461 tctccgtttt tttaccgtat acgggccaag acagcggccg gatatggctt ttcaccggct 2510521 cattaagcag caccttcagc aaaagccgct taccatcttc ggtgatgggc agcagtcaag 2510581 agatttcact tatatcagcg actgtgtcaa aggcatcacc gctgttcttg ggaaacccca 2510641 ccttattggt gaaacagtaa atatcggcgg cgcagagcgt gcctcagtct taaaagttgt 2510701 ctccctcatt gaggatattt ccgggagaaa agcaacactg cacttttcgg acaaaatagc 2510761 aggggaaccg agcaacacgt gggcggatat ttcaaaagca aaacagctct tgcattatga 2510821 tcccgccaca tccttaaagg atggcttgac caacgaaatc gcctatttat cgtcgctgta 2510881 tcagggggaa taaaaatgaa gcttgccttt atctgtacag aaaagctgcc ggcgcccgca 2510941 gtacgcggcg gcgctattca aatgatgatt gacggtgtca cgccctattt cagcagcagg 2511001 tacgacctga ccattttttc aatagaagat ccatcgctcc caaaaagaga aacaaaagac 2511061 ggcgtacatt atatccatct gccaaaagaa cattaccgcg aggcggtagc cgaagagctg 2511121 cgagcctctt cctttgacct cattcatgtg ttcaacaggc ctttaaatgt ctctttatat 2511181 aaaaaagcct caccaaacag caagatcgtt ctgagcctgc ataacgaaat gttttctgaa 2511241 aaaaagatga ccttcgcgca aggaaaagaa gtactcgaca atgtctccat gatcacaaca 2511301 gtgagcgaat ttattaaaca aaccgtcatt gaacgtttcc ctgaagccga ggacatcaca 2511361 aaagttgtgt attccggcgt tgatttaaac tcttatccgc ccgtctggac gatgaaaggc 2511421 tcggctgtca gaaaaacata ccggaaaaaa tacggtattg aagataaaaa agttatttta 2511481 ttcgccggcc gcttaagccc gacaaaaggg cctcaccttc tcattcacag catgagacgg 2511541 attttgcagc agcaccctga tgctgtactg gtcatagcag gcgggaagtg gttcagcgat 2511601 gacagcgaaa accaatatgt cacctatctg cgcacgctgg cgctgccata cagagaccac 2511661 ataatcttta caaaattcat tcccgcagac gatatcccaa acctttttct gatggcagat 2511721 gtatttgtgt gcagctctca gtggaacgaa cccctcgccc gtgtgaatta tgaagcaatg 2511781 gcggccggca cgcccttaat taccacaaac cggggcggaa acggtgaagt cgtaaaacac 2511841 gaagtcaccg gccttgtcat cgatagctac aacaaacctt cttcatttgc aaaagcaatt 2511901 gacagagcct ttacagatca agaattaatg aacaaaatga caaaaaacgc ccgaaagcat 2511961 gtagaagctt tatttacctt tacccatgct gccaaaaggc tcaatactgt ttaccaatcc 2512021 gttctgaccc cgaaaaacaa acaatttccg ccgccttttc tgacgcaaaa ttttgattta 2512081 tcatctatca atcagctttt tgtgaaagca aaaacataaa acctacagct cgtgttgcaa 2512141 aacgggctgt tttttcgcta cagagaactt aaaaaaaggc ataaatgtga ctttatgcct 2512201 tgcgctttac agtttgagaa aaccatggag ctggtttaga ttcacttgga agaatgatga 2512261 tttccacttt agcttcttcc gctaagtctg gttcttcatc ttcatcctct tcttcatatg 2512321 ggggcgctga gcgtttcgaa tcacgctcct cctcaggctc cagagtggtt tcgaattttg 2512381 tttcttcttc atcatcgacg attttgcgat ctgtttcctt ttccttcgtt tctttttgat 2512441 attctttcgg tgcattgatg tgagggagct ctcgaatgct gcccacatct aaatgcttct 2512501 cctcttcttc cttctcagct gagattgagt catgagcctg ccatcccatc ggtccaggcg 2512561 gtgtaaatac gaattggtcg agatccagtt tagaaataga ggctttttgt ctcgatgacc 2512621 tcatgtcaat tcgcctcccg atacgctttt atctttttat acagttccgg cagtttatcc 2512681 aaaaacgaat ctttagattc ttcaacagaa atcatgtttt gcagcgccca gttatacttc 2512741 tcatctgacc acgttttctt ttgcttcaaa taatatttgt gcccgattgc acagaacaaa 2512801 tgcggaaacg cgagatcaat ccaaagtacc tcgtactgtt tttctgtgag cggatacact 2512861 gcgtcgtagg ccgcaagcag tgcaaccatg aaatcagtat cccatacaga aagcttaacc 2512921 atcactttat tcagcagaat acgaaggtct cttgacggca aatcgtaggt aatcgagtga 2512981 agctccttta aaaaaggctc cccttcgatc tcagtcaaac gtgccaatgt aaaatcctga 2513041 aaacagaatc cgccatgctc gagtgtctct tttgtccagg tttcgtattc tgagtcatca 2513101 agcgctctga gagcttcttt tcctcttgcc agcattttat cagcatgttt taagaaagtt 2513161 tgcgaaaata cgtcatcagg ataggatgct gcgatctgca tattcccttc aagttcctgc 2513221 agcttccaac ggtacaattt gtgccatttt cccagcctgc ttctcttctt gctttcatct 2513281 gtgcaaacat atccttttga ggcatgatga aaatggccgg caaatgacat gacttttttc 2513341 atttgctctg catcatagta aatcatttct tttcctgtca ctttgtcata taaactgtaa 2513401 gaaacctgat ccgtgcccaa gcagctaccg ccattttttg tttgatgaat cggcgctatc 2513461 ggcagccctt tctcttgtaa atgggcgtgt gcctgagtga taaaaagcat ccgctccggt 2513521 ttcatttgcg cttcttttag cagctttggg ccatgatcag tttcgacttc ccagattttg 2513581 cgcccgcttt tgttcgattt cagcgccaca tggtcgatat gaaacggata ataactgaga 2513641 atttcggaca caatctgttc ttcatgctct ttttggtaca ctctgttcac cccttctatc 2513701 tgttcttttc atagacgctg agcagatttt cagccaccct ctgccagcca aaattgcttt 2513761 ctgcctcacg gcggctgtat ttcccaagcc gttcccgctt ttccgagctg ctcagcaaat 2513821 cattgatacg ttcggcatat tgtttaggat tttcaaagtc atgaatgatg tagccgtttt 2513881 tcccttcctc tatgacctct ggattgcctc cccgattgct tgtaataata ggaagtcccg 2513941 cagccatcgc ttcataatgc acccttgcta aaggctcctg ccattgcgaa gagcatacaa 2514001 atacatctga catggtataa aggcgcggaa tgtcctttgg cttcacaaat tgaataaatg 2514061 tgacatgatc cttttgcatc gcaccaaggg tatgaagatg tttgacatag ttatttaatt 2514121 cattatctcc gaaccatttt gacccgataa acaccatcat gacatcgggg tgctcctcaa 2514181 tgatgtccgg caaagcctgc aataatatgt gcgggccttt gactttgcta agccggccga 2514241 caaacaagac gatttttttg ccgtgaagcc ccagctcgct tcgcatctct tcgcgagctc 2514301 gctgcccttc attcgtccag cgagggtggt acgtttttaa atccacacca gaatacaccg 2514361 tttttgtttt tgatcgtgct gacggaaaac ggcttgtgat cgtctgtccg atataatcgc 2514421 tgaccgtaac aatctgcgct acggagtcga tgcaaatctc gccttccgcc tggctgattt 2514481 tatcgtaagc gaacatttca ttgtgaacgc ttaaaataaa aacagcatcc ggcgcctgtt 2514541 tcttcaattt cggaacccag cttgggcgat tacaaacatg cacaagatca aaacggctct 2514601 ttttcagctc tgctccaacg gcttcttcat aacggtcttc atccaaatgc acataatgga 2514661 caccgtctac cttctctcta tcagcgagat tcggatcttt aatagaaaac acagtcacct 2514721 catgtttttt tgcaattaaa ggggcaaccg cttcgaggta gatttgaatg gcgcctcctc 2514781 gaaccgatgg gacaggaagc ttctctgtgg cgatcagtgc tattttcata catagcctcc 2514841 attcctgcat gatttttaac tagttagaat catgatacgg ctgaacaacc aacttgtgcg 2514901 gaatgggact gccctaaaaa caaaacgggt aaacaaccag attcatctat taaatatagt 2514961 caaataactc aatcattttt tccttttgat tcataaggta ggagtaaaac aggtaaggat 2515021 gtgtccttta atggcagaaa accatgaagt cattgaggag gggaattcat cagagcttcc 2515081 tttatcagca gaagatgcaa aaaaattaac ggagctggct gaaaatgtgc ttcaaggatg 2515141 ggatgtgcag gctgaaaaaa tagacgtcat tcagggaaac cagatggcgc ttgtctggaa 2515201 ggtccacaca gactccggcg cggtttgtct aaaacgaata cacaggccag aaaagaaagc 2515261 gttgttttcc attttcgcgc aggactattt agcaaaaaaa ggcatgaatg ttcctggcat 2515321 actcccaaac aaaaaaggca gcctatattc taagcacggc tcatttctat ttgtcgtata 2515381 tgactggatc gaaggaagac cgtttgagct gactgtaaag caggacttgg agtttatcat 2515441 gaaaggcctt gctgattttc atacagcttc cgtcggatat cagccgccaa atggcgttcc 2515501 catatttacc aaattaggtc gctggccgaa tcactacacg aaacgatgca aacagatgga 2515561 aacgtggaag ctgatggcgg aggcggaaaa agaagatcct ttctcacagc tttatcttca 2515621 ggagatagat ggctttattg aagacgggct gcgcatcaaa gaccggcttt tgcaatcgac 2515681 ctatgttcca tggactgaac agctgaaaaa aagccctaac ctttgccacc aggattacgg 2515741 aaccgggaat acactcttag gagaaaatga acagatttgg gtcatcgact tagataccgt 2515801 atcatttgat ctgcctattc gcgatttgcg caaaatgatt attccgcttt tggatacgac 2515861 gggtgtttgg gatgacgaaa catttaatgt catgctgaac gcatacgaat ccagagcccc 2515921 attaactgaa gaacaaaaac aagtcatgtt tattgatatg ctgtttcctt acgagcttta 2515981 cgatgtcatt cgcgaaaaat acgtccgcaa gtctgcttta ccgaaggaag aattagaatc 2516041 agcttttgaa tatgaacgca ttaaagcaaa cgcattgcgg cagcttattt aagaccatca 2516101 tttcccccgc atatcggggg tttgatattt ataagataaa gggtaattaa atacatgcgg 2516161 aggttgcaaa tatgaaaaag attgtcggcg ctttagccgt ttttgtgatt acatatgcgc 2516221 tgttttcagc cgcaggctac ctgtttcctg tggaccaaga atggtacaat tcattgaaaa 2516281 aaccggactg gacgccaagc ggaactgcga tcggcatcat ttgggccatc ctgtttgccc 2516341 tgatctccct ttcagcagcc attgtatatg ctgcgttttc atttaaaggt gcgaaaagct 2516401 tttggtttac acttttgata aattacgtgc tcaatcaagc cttcagctat ttccagttta 2516461 cgcaaaaaaa tctgctggct gcatcgcttg actgcctgct tgtcgccatc acagcaatcg 2516521 tattactgat cattgccaaa aaatacagca gagccgcaag ctatcttctt ttgccttatt 2516581 ttttatggag tgcatttgcg acgttcttat cctttacaat caattcaatg aatctgtgaa 2516641 caaaaaaagc cgcttataca gcggcttttt cacatcatcg gcttgatgcc ccaaatgtcc 2516701 ttcgcatatt cccggatcgt gcggtcgctg gagaaatatc cagaatgagc aatgtttaca 2516761 atcgaatgct cagaccattt ccttcgctct cgataatcag cttgaattcg ctcctgtgca 2516821 tctgcatatg agctgaaatc cttcagcaca aaatactcat cattatgcgg aagcagcgag 2516881 tcaaagatcg attcaaattc atctgcctct ccttcaaaaa aaccattgat caactgatcc 2516941 gctacctgcc tgattctcct gtcatgctga taatattccc tcgacctata gccgccgttt 2517001 tcctgatacg atagaacctc atccgccttt aagccgaacg tgtaaataca gtcagggccc 2517061 acccgctcaa ggatctcgat atttgcgccg tcatgcgtgc cgatcgtcaa agccccgttc 2517121 atcataaact tcatattccc tgtaccagac gcttccttgc ttgcggttga aatttgctca 2517181 cttacgtctg atgccggaaa aattcgctca gccatagaaa ctctataatt ttctaaaaaa 2517241 acaactttga tcagctgttt gaccgccgga tcataattga ctttttctgc gacagaatgg 2517301 atcagcttaa tgattttctt ggcataataa tagcttggtg aagcctttgc cccgaaaata 2517361 aaggtttgcg ggtagattga aaaccccgaa tcctccttga ggcggttata caaatacata 2517421 atgtgaagaa cattcagcag ctgccgttta tatgcatgaa gccgtttcac ctgtacgtcg 2517481 aatatgctct cagggttcac aaccaccccg gccgtgcaaa aaatcaaatc ggcaagctct 2517541 tgttttttct tgcttttgtt gttttgaaac tgttcaataa atgcaggatc agtggcgtac 2517601 ggttctaaac ggatcagtga ttccggctgc ttgacccatt catcgccgat cgcctctgta 2517661 atgatggcag acaagcctgg attcgctttt aacagccagc gcctgtgggc aattccattc 2517721 gtcttattgt taaaacgatt cggaaacagc aagtgaaagt cgcgcatctc cctttccttt 2517781 aatatatcgg aatgtatttt tgcaacgcca tttacactgt agctgcctac tatggccaga 2517841 tgagccattt tgacaacacc atgcgctgta atcgccatgt tctctatcct tttccagtct 2517901 ccaggatact tttcccaaac tgcacggcaa aacctctcat tgatctcttc aataatcatg 2517961 tacattcgcg ggagcagcgg cttaaacaaa tgaatcggcc atttctcgag cgcttctgac 2518021 aatgttgtat gatttgtata agaaatcgta tgtacagtga tatgccaagc ttcttcccag 2518081 ctcatgttct cttcatcgag caaaatccgc attagctcag gcaccgcaag cgcagggtga 2518141 gtgtcattaa tatgaatgct cactttttta tgcaggccgg ataaagattt atgtgtttta 2518201 cggtaattgt tcacaatgct ttttaagctt gcgcatacta aaaaatactg ctgcttcagc 2518261 cgtaaaattt tcccctcatc atgggtgtca tcgggatata agaattcaga aaccgcttct 2518321 gtttctcgct tataagacaa aatattaccg ccgtgataat gggcataggg ctcggcgttc 2518381 caaagcctta acgtgttgac agtgcccgtt tcatagccga tgatcgggat atcataagga 2518441 acagcggtaa caattgtcgc ttgttcatgg cgaaaatgca ggcgcccgct tttttctgtc 2518501 atatggactt cgccccaaaa cggcacgtcc actgcttgat ccgcattcct tacttcccat 2518561 acgttcccgt ttttcagcca ttgctcaggc agctccacct gatgtccgtc tacaattttt 2518621 tgctcaaaca aaccatgctt ataacgtatg cccatgccgt gcccaggcag gttcaacgaa 2518681 gcaagcgaat ctaaaaagca agcggccaag cgcccaagtc cgccattgcc gagacctgca 2518741 tcgttctcta tctgaaggat ctcctctaaa ttgatgccga tttcctttaa accagcttct 2518801 acaacatcac gaacaccaag attcattaag ttttgctcaa ggagctgacc gagcagaaat 2518861 tcgattgata aataatatgt ctgcttcccg gaatttgatc tgcttttttc attcgtttcg 2518921 atccaatcag cgctgatata ctctctgacc atattgccca acgttttata ttgatccagc 2518981 ttggcagaat ctttaaagct ttttccgcac gtcatttcca gacgctttaa aaataagtct 2519041 gcaaagcgtt ctttactcga gaacatcccg tccactcctt gtcacctgct cgaaaatacg 2519101 ctgatactct ttagccgact tcccccagct gtaatctgca ttcatagcgg tcttcacgat 2519161 gctcttccat acatcctgtt ggcaataaaa cgacagcgcc ctttctatcg taaatttcag 2519221 atcatgcgca ttaaaggcgg aaaacgtaaa gccattgccc gttccctctt cctcctgata 2519281 ggcacggaca gtgtcgtaaa gaccgcccgt ttccctgaca atcggaatgg cgccatattg 2519341 aagagcaatg agctgcccca aaccgcacgg ctcaaatttc gacggcatca aaaacatatc 2519401 agagcccgca taaatttgat gggctagcgg ctcatcaaac ccgatataag cccggcactt 2519461 ctcatgaaaa gcaaattctg cataccggaa ataatcttca aattcacgtt ctcctgtgcc 2519521 tagcacaacc agctgtatgt cttgctcctc aagaagttcg tgcataattc tgcggacaag 2519581 atcaagcccc ttttgtttag tgagccttgt caccatactg atcagcggaa tatcgttttt 2519641 ctctggaagc cccatccgct gctgaagctt cgttttgttt tccagcttgc atgcaagatc 2519701 ccctgaatcg tattgcgcct ctatataagg gtcgcttttc ggctgataga acgtatcatc 2519761 aatgccattt aatatgccgg ttacatcatc ttccctatat tgcaaaacct gttccaactg 2519821 ctcaccataa tacggcgtca tgatttcatt tctgtaagtg gggctcacag ttgtcacatg 2519881 atcagccgca atgatgcccg ctttcataaa attaacaaat ccgttgcatt ctaacctttc 2519941 ataatgaaaa tgatccatct caagacccag caagtcatgt gtgacatcag gagggaatat 2520001 gccttgaaac tgcaggttgt ggatcgtgag cacgcttttc atccgttcat aaaaaggatg 2520061 ttttctgtac tcctctttca gcaaataatt gaccatcgct gtatgccaat cgtgagtatg 2520121 aacaatatcg gcttgaacat tcacaacttt ggcagcctcc agcacagctc ttgaaaaaaa 2520181 ggcaaaccgc tcaccgtcat cataatgccc gtacaacgaa tccctgttga aatagtactc 2520241 attgtcgatg aagtaataat tcacatcatt ctctgccata tgttcaattc cgcaatattg 2520301 ctgccgccag ccgacagcta cggtacactc agcctgtttt ttcatacgct ttttccacgg 2520361 ttcaggtatt tggctgtact tcggcagcat cacagctacc tcattgccta atcgcgcaag 2520421 cgcctttggc agagcacctg ctacatcggc aagacctcct gatttcacaa atggggtgca 2520481 ttctgacaca gcaaataata tcttcaagaa ttcatcagct ctccttgcac caaacctttt 2520541 cttaatacaa gcggctgctc agctgttcct gcagcttccg tcgccttgcc gattttaaca 2520601 tccttatccg aaatgacctg ctcaagaaga caatcctctc caatctgcgt tttttgcata 2520661 ataatgcagt ttttcagctt cgtacccttt ccgacatgga ccgccctgaa caaaatgcag 2520721 ttttcaacct ctccttcaag cacacagccg tttgccacca aagaattttt gacagtgctg 2520781 tgctttccgt atttcgtagg cggctcatcc ttcacttttg tatagatcgg ctgctgcggc 2520841 aaaaacacct gctgccaaaa acgaggctga atgagctcca tactgtgggt ataatatttt 2520901 tccaccgaat caatgacagc ggcataacct gaatattcat aagggcaaat ggtcagggcg 2520961 gaagattcct tttcaacagc ctcctgaatg gttttatagc ctttttcgct atgtccgtag 2521021 atcagatcct ttaaaagcgt tgttgacatg atatagattt gcagcgactg gccgtcctga 2521081 aatacctcgg tgacgtcgca gccaacctcc tgatggcgtt tcagcacata ttgaaattga 2521141 atgttgcata cggtatggct gttggagatt acagcatatt gctgagtgct tctgtggaag 2521201 taatctagat ggtccgaaaa ctggcgaaag gaaccgaatt catcgtattc gtgatgaaga 2521261 tggggagacg ggaaaaaaaa gaggccgtcc tttttccggt gcaaatccca ttccttaccc 2521321 gccccaaggt gatccatgag cgaacggtaa cgatacttcg gaaaaattgc aacactccta 2521381 atatccgcat tcaccatgtt ggaaagcata aaatcaatca gtcggtacct gccggcaaaa 2521441 gggatcgccc cgagcgaccg ctgtgctgtt aaatcctgaa gagaatgctt atatgtggtt 2521501 tcatctataa cacctaacat ttgattattg aacactgact ctgccccctc ttcagtaatt 2521561 aaatcaattc tttttctaca aattcctctg aaacgagcag cacctcttca atgtcttttt 2521621 cggagcgaat cactgcgcca tccggcagca ccatcccatt aggaacgatg gcattttcaa 2521681 tgactacatg ctccccaatc gtcacatccg gcattatgac ggatgatgta acagtcgtat 2521741 gcttaccaac agtcacacct tgaaaaagaa cggagtgaga cacatttcca tatacaacac 2521801 aaccttcgtt cacaagcgaa tcttgaacct gcgcatcaga tgaaataaat tgcggaggct 2521861 gatttggatt gacggagtaa attttccatt tgcgttcaaa cagcttcagc tccgagtcct 2521921 cttttaacaa atccatattg gcttcccaca agctctgcac cgttccgaca tccttccaat 2521981 atcccttgaa cggataagca gaaagcttct ttttctcttc caaaagcagt ggaataatgt 2522041 ctttgccgaa gtcgtggcta gaataagggt tttgatcgtc catctcaaga tactgtttca 2522101 aaagcggcca attgaatata taaattccca ttgaggcaag attgctctta gggaatttgg 2522161 gcttttcatc aaaatgtgtg atcgtcccat ctggattggc cttcatgatg ccgaaccggc 2522221 ttgcttcctc ccagcccact tcgatgacag agatggtcac atctgctttc ttttcaatgt 2522281 gataatcaag cattttgccg tagtccattt tgtatatgtg atctcctgat aaaatcagta 2522341 catactcagg atcatactga ttcaaataat tgagattttc ataaatggag cttgccgtcc 2522401 ctttatacca tttgacttct gatgactcgg cataaggggg taaaaccgtc acgccgccat 2522461 tatatctatc caggtcccat gcactgccga tcccaatata ggaattcagc tcgagcggct 2522521 gatattgcgt taaaatcccg actgtgtcta tgcctgaatt agaacagttg cttagggtaa 2522581 aatcaataat cctgtatttt cccccgaaag atacagccgg tttggccata ttttttgtta 2522641 atccgctgag acggctgccc ttcccgccgg caaggagcat ggctacacat tgttttttca 2522701 tctttttatc tctcctcttt ttttaaccgc ccgtaaaatc gagatgccgt aaggggggat 2522761 ggtcatcgtg atataacacg gtttatgatg aagtgctccc tttttagccg ataacggctt 2522821 tttgttgatt tgccctgagc ctccatatgt ttcactgtca ctgttaagca cttcaatgta 2522881 ttgagtaaaa aaaggaactc caacatcata ttgatgatag accacgggtg taaaattaca 2522941 aatgatgaca agcgcctcac cgtgcttttg gccataacga ataaaagaaa agattgattg 2523001 ttcgtcatta tggacatcaa tccattcaaa cgattgtgca cgatggtcat gctcataaag 2523061 gattttgctt ttttggtaaa agcggagaag atcttgcgta aaaacgctgg ctttctgatg 2523121 catggggaag gagtccaaaa accaatcaag ctgttctgta tctttccatt catcaaattg 2523181 agcaaactct gatcccataa agatcaattt ctttccggga tgcactgtca tatagcccag 2523241 caaaagccga tactgggcaa atttctgcca gtagtcgcca ggcattttat tgagaagtga 2523301 tttttttccg tatacgactt catcatgaga aaacggcaat acaaaatgtt cactaaacgc 2523361 atatagtaat gaaaaagaga taagctgatg acaatgccgc ctttcttcgg gcggcgtctc 2523421 catgtatttc agtacgtcat tcatccatcc catattccat ttataatgaa aaccaagccc 2523481 cccttcctca acggcacctg tcacttgagg ccattctgta gaatcttctg caatcatcat 2523541 cacatgggga tatgcctctc tcatggtttg attgagtttt tttaaaaaat caacagcata 2523601 tggattcgtg tggcgttcat cctgatttgg ccaatacaag atattagcca ctgcatcaac 2523661 cctaaatcca tctatatgat agaattccgc ccagtacaac gcattcgaaa ttaaaaaact 2523721 atgaacttcc ggtttcccca ggtcaaagtt tgccgtgccc cataaccagt tctcccgatc 2523781 acgttcttct ttgtattcat aaagcggttc tccatcaaac atataaaggc catgtgcatc 2523841 tttacaaaaa tgtccgggga cccaatccaa aatgactccg atattttgtt gatgacattc 2523901 atccacaaac ttcatcagat catgcggcgg gccaaacctg cttgtcgggc tgtaataccc 2523961 cgttccttgg tacccccatg aacgatcata tggatgctca tacacgggaa gcagttcaat 2524021 atgggtaaac ccatgcttct tgatataagg gataagcgtc tgacttaatt ctttatagga 2524081 ataatgcctg ccatcagaat gcttcttcca agacccaaga tgcagttcat aaatgaaaac 2524141 aggtttttca tacagcgtct tagccttctg tttcttttgc catttttgat cttgccagct 2524201 gtatccttcc aaatcgtaag taagtgacgc tgtgtttggt ctgacttctg aataaatagc 2524261 gtatggatct gccttcagcc tgatctcacc gttattcgtc acaatttcgt atttatatcg 2524321 ttccttttct cctatacctg gaataaataa cgtccaaatg ccattatcat tcactctgtg 2524381 catcacatgc tcttctccag accagctgtt aaaatctcca gccactcgta cttccgacgc 2524441 atgaggcgcc cacacacaga attcatatcc gcttttgcca ttcagctcgc ggtaatgcga 2524501 gccaaacagc tgatagcttt taaacagact gccttcgtga aaaagataaa catcatgtgc 2524561 tgtcgggctg gcagcggcca tgtaatcatc ctttctgaca tcatagtttt catttatagt 2524621 atttattcga agaaataaaa aaaagccctt tcctgaaagc gcttatactt atagacaatt 2524681 aacttcattt tctgaagaaa aacgaaatat atggagattt ttgtagtctg tttttaaaat 2524741 aaagaacaaa atctaagaca tatcatgatt tataaaaaca aaaaaacctt gcaggatatg 2524801 caaggcttct ggatgacccg tacgggattc gaacccgtgt taccgccgtg aaagggcggt 2524861 gtcttaaccg cttgaccaac gggccgataa ttatgatatc tgtaatcata tggcggagaa 2524921 ggagggattt gaaccctcgc gccgcttaca cgacctacac ccttagcagg ggcgcctctt 2524981 cagccacttg agtacttctc catttggctc cacaggcagg attcgaacct gcgaccgatc 2525041 ggttaacagc cgatagctct accactgagc tactgtggaa caaaagtcat ggtgggcctg 2525101 aatggactcg aaccatcgac ctcacgctta tcaggcgtgc gctctaacca gctgagctac 2525161 aggcccatga cgatatagaa atggagcggg tgatgggaat cgaacccacg acatcagctt 2525221 ggaaggctga ggttttacca ctaaactaca cccgcaattt ttatttgggg cgattgatgg 2525281 gaatcgaacc cacgaatgcc agagccacaa tctggtgcgt taaccacttc gccacaaccg 2525341 ccaaagcata ttgataaatg gtggctcggg acggaatcga accgccgaca cacggatttt 2525401 cagtccgttg ctctaccaac tgagctaccg agcctaagta tttaaatggc ggtccggacg 2525461 ggactcgaac ccgcgacctc ctgcgtgaca ggcaggcatt ctaaccaact gaactaccgg 2525521 accattttaa aatttggttg cgggggcagg atttgaacct gcgaccttcg ggttatgagc 2525581 ccgacgagct accgaactgc tccaccccgc gatgattagg aatatgtatg gcggaggaag 2525641 agggattcga acccccgcgg gctttgacac ccctgtcggt tttcaagacc gatcccttca 2525701 gccagacttg ggtattcctc cgtatagtgg tggaccttgt aggactcgaa cctacgaccg 2525761 gacggttatg agccgtctgc tctaaccaac tgagctaaag gtccattggt agcggcggag 2525821 gggatcgaac ccccgacctc acgggtatga accgtacgct ctagccagct gagctacacc 2525881 gccaaatatt tttgaaatca agtggagcct agcgggatcg aaccgctgac ctcctgcgtg 2525941 caaagcaggc gctctcccag ctgagctaag gccccaagaa tggtcgggaa gacaggattc 2526001 gaacctgcga ccccatggtc ccaaaccatg tgctctacca agctgagcta cttcccgatt 2526061 tcatatagat catggcgcgc ccgagaggag tcgaacccct aaccttttga tccgtagtca 2526121 aacgctctat ccaattgagc tacgggcgca aaacttaatg ccgagggccg gacttgaacc 2526181 ggcacggtag tcacctaccg caggatttta agtcctgtgt gtctgccaat tccaccaccc 2526241 cggcgtggat ggtatagttg gagcggaaga cgggattcga acccgcgacc cccaccttgg 2526301 caaggtggtg ttctaccact gaactacttc cgcagaaatg gtgcggatga agggacttga 2526361 acccccacgt ctgtaaagac actagagcct gattctagcg cgtctgccaa ttccgccaca 2526421 tccgcaacat gtaaatggtg agccatgaag gactcgaacc ttcgaccctc tgattaaaag 2526481 tcagatgctc taccaactga gctaatggct cttcttacaa tagacttgaa tattatatca 2526541 tataaaagtg gtgccggcaa gaggacttga acccccaacc tactgattac aagtcagttg 2526601 ctctaccaat tgagctacac cggcatatat gtaaaaccga tatgtataat gaaaaatggt 2526661 ggaggatgac gggctcgaac cgccgaccct ctgcttgtaa ggcagatgct ctcccagctg 2526721 agctaatcct ccatacttgc actaacgtgc aattgcttgg cggcgtccta ctctcacagg 2526781 gggaaacccc cgactaccat cggcgctgaa gagcttaact tccgtgttcg gtatgggaac 2526841 gggtgtgacc tcttcgctat cgccaccaaa caaattgaga gtgttctctc aaaactagat 2526901 aacaggtgtg acatcattca aaaatatggt taagtcctcg atcgattagt atctgtcagc 2526961 tccatgtgtt gccacacttc cacctcagac ctatcaacct gatcatcttt cagggatctt 2527021 acttccttgc ggaatgggaa atctcatctt gaggggggct tcatgcttag atgctttcag 2527081 cacttatccc gtccgcacat agctacccag cgatgccctt ggcagaacaa ctggtacacc 2527141 agcggtgcgt ccatcccggt cctctcgtac taaggacagc tcctctcaaa tttcctgcgc 2527201 ccgcgacgga tagggaccga actgtctcac gacgttctga acccagctcg cgtaccgctt 2527261 taatgggcga acagcccaac ccttgggacc gactacagcc ccaggatgcg atgagccgac 2527321 atcgaggtgc caaacctccc cgtcgatgtg gactcttggg ggagataagc ctgttatccc 2527381 cggggtagct tttatccgtt gagcgatggc ccttccatgc ggaaccaccg gatcactaag 2527441 cccgactttc gtccctgctc gacttgtagg tctcgcagtc aagctccctt gtgcctttac 2527501 actctgcgaa tgatttccaa ccattctgag ggaacctttg ggcgcctccg ttacctttta 2527561 ggaggcgacc gccccagtca aactgcccac ctgacactgt ctccccgccc gataagggcg 2527621 gcgggttaga aggtcaatac agccagggta gtatcccacc gatgcctcca ccgaagctgg 2527681 cgctccggtt tccaaggctc ctacctatcc tgtacaagct gtaccaacat tcaatatcag 2527741 gctgcagtaa agctccacgg ggtctttccg tcctgtcgcg ggtaacctgc atcttcacag 2527801 gtactataat ttcaccgagt ctctcgttga gacagtgccc agatcgttgc gcctttcgtg 2527861 cgggtcggaa cttacccgac aaggaatttc gctaccttag gaccgttata gttacggccg 2527921 ccgtttactg gggcttcaat tcgcaccttc gcttacgcta agcgctcctc ttaaccttcc 2527981 agcaccgggc aggcgtcagc ccctatactt cgccttacgg cttcgcagag acctgtgttt 2528041 ttgctaaaca gtcgcctggg cctattcact gcggctctct cgggcttgca ccctaacaga 2528101 gcaccccttc tcccgaagtt acggggtcat tttgccgagt tccttaacga gagttctctc 2528161 gatcacctta ggattctctc ctcgcctacc tgtgtcggtt tgcggtacgg gcacctctca 2528221 cctcgctaga ggcttttctt ggcagtgtgg aatcaggaac ttcgctacta tatttcgctc 2528281 gccatcacag ctcagcctta tgggaaacgg atttgcctat ttcccagcct aactgcttgg 2528341 acgcggatat ccaataccgc gcttacccta tcctcctgcg tccccccatt gctcaaatgg 2528401 tgaggaggtg gtacaggaat atcaacctgt tgtccatcgc ctacgccttt cggcctcggc 2528461 ttaggtcccg actaaccctg agcggacgag ccttcctcag gaaaccttag gcattcggtg 2528521 gaggggattc tcacccctct ttcgctactc ataccggcat tctcacttct aagcgctcca 2528581 ccagtccttc cggtctggct tcacagccct tagaacgctc tcctaccact gttcgaagaa 2528641 cagtccgcag cttcggtgat acgtttagcc ccggtacatt ttcggcgcag agtcactcga 2528701 ccagtgagct attacgcact ctttaaatgg tggctgcttc taagccaaca tcctggttgt 2528761 ctaagcaact ccacatcctt ttccacttaa cgtatacttt gggaccttag ctggcggtct 2528821 gggctgtttc cctttcgact acggatctta tcactcgcag tctgactccc aaggataagt 2528881 cattggcatt cggagtttga ctgaattcgg taacccggta ggggccccta gtccaatcag 2528941 tgctctacct ccaagactct taccttgagg ctagccctaa agctatttcg gagagaacca 2529001 gctatctcca ggttcgattg gcatttcacc cctacccaca cctcatcccc gcacttttca 2529061 acgtgcgtgg gttcgggcct ccattcagtg ttacctgaac ttcaccctgg acatgggtag 2529121 atcacctggt ttcgggtcta cgaccacgta ctcatgcgcc ctattcagac tcgctttcgc 2529181 tgcggctccg catcttctgc ttaaccttgc acgggatcgt aactcgccgg ttcattctac 2529241 aaaaggcacg ccatcacccg ttaacgggct ctgactactt gtaggcacac ggtttcagga 2529301 tctctttcac tccccttccg gggtgctttt cacctttccc tcacggtact ggttcactat 2529361 cggtcactag ggagtattta gccttgggag atggtcctcc cggattccga cggaatttca 2529421 cgtgttccgc cgtactcagg atccactcag gagagaacga agttttgact acagggctgt 2529481 tacctcctat ggcgggcctt tccagacctc ttcatctacc tcgttctttt gtaactccgt 2529541 acagagtgtc ctacaacccc aagaggcaag cctcttggtt tgggctgatc ccgtttcgct 2529601 cgccgctact cagggaatcg catttgcttt ctcttcctcc gggtacttag atgtttcagt 2529661 tccccgggtc tgccttctca tatcctatga attcagatat ggataccact ccattacgag 2529721 tggtgggttt ccccattcgg aaatctccgg atcaaagctt gcttacagct ccccgaagca 2529781 tatcggtgtt cgtcccgtcc ttcatcggct cctagtgcca aggcatccac cgtgcgccct 2529841 ttctaactta accgttaaaa agaatcacta tgtgatatct tgtgttacta attgaatgtg 2529901 atgtctactg ttatctagtt ttcaaagaac acgtttcgaa ggaatgatcc ttcaaaacta 2529961 aacaagacag ggaacgttct gtttataaga ccttgggtct tatattccgt ataatatcct 2530021 tagaaaggag gtgatccagc cgcaccttcc gatacggcta ccttgttacg acttcacccc 2530081 aatcatctgt cccaccttcg gcggctggct cctaaaaggt tacctcaccg acttcgggtg 2530141 ttacaaactc tcgtggtgtg acgggcggtg tgtacaaggc ccgggaacgt attcaccgcg 2530201 gcatgctgat ccgcgattac tagcgattcc agcttcacgc agtcgagttg cagactgcga 2530261 tccgaactga gaacagattt gtgggattgg cttaacctcg cggtttcgct gccctttgtt 2530321 ctgtccattg tagcacgtgt gtagcccagg tcataagggg catgatgatt tgacgtcatc 2530381 cccaccttcc tccggtttgt caccggcagt caccttagag tgcccaactg aatgctggca 2530441 actaagatca agggttgcgc tcgttgcggg acttaaccca acatctcacg acacgagctg 2530501 acgacaacca tgcaccacct gtcactctgc ccccgaaggg gacgtcctat ctctaggatt 2530561 gtcagaggat gtcaagacct ggtaaggttc ttcgcgttgc ttcgaattaa accacatgct 2530621 ccaccgcttg tgcgggcccc cgtcaattcc tttgagtttc agtcttgcga ccgtactccc 2530681 caggcggagt gcttaatgcg ttagctgcag cactaagggg cggaaacccc ctaacactta 2530741 gcactcatcg tttacggcgt ggactaccag ggtatctaat cctgttcgct ccccacgctt 2530801 tcgctcctca gcgtcagtta cagaccagag agtcgccttc gccactggtg ttcctccaca 2530861 tctctacgca tttcaccgct acacgtggaa ttccactctc ctcttctgca ctcaagttcc 2530921 ccagtttcca atgaccctcc ccggttgagc cgggggcttt cacatcagac ttaagaaacc 2530981 gcctgcgagc cctttacgcc caataattcc ggaaaacgct tgccacctac gtattaccgc 2531041 ggctgctggc acgtagttag ccgtggcttt ctggttaggt accgtcaagg taccgccctg 2531101 ttcgaacggt acttgttctt ccctaacaac agagctttac gatccgaaaa ccttcatcac 2531161 tcacgcggcg ttgctccgtc agactttcgt ccattgcgga agattcccta ctgctgcctc 2531221 ccgtaggagt ctgggccgtg tctcagtccc agtgtggccg atcaccctct caggtcggct 2531281 acgcatcgtt gccttggtga gccgttacct caccaactag ctaatgcgcc gcgggtccat 2531341 ctgtaagtgg tagccgaagc caccttttat gtttgaacca tgcggttcaa acaaccatcc 2531401 ggtattagcc ccggtttccc ggagttatcc cagtcttaca ggcaggttac ccacgtgtta 2531461 ctcacccgtc cgccgctaac atcagggagc aagctcccac ctgtccgctc gacttgcatg 2531521 tattaggcac gccgccagcg ttcgtcctga gccaggatca aactctccga taaatggatc 2531581 acaggttaag ttcaccgcat cctgcggcga cacctgtgtg acctgcgtcg tgcaggccct 2531641 agtttgactg actacgcaca tcgcagtgcg atttttaaaa actgaattaa caggtacgtt 2531701 ttgtcttgtt tagttttcaa agatcatttc gttacttctc aatgaagcag ctttactaat 2531761 ataacattca gcttcttttt tgtcaacaac ttttttcaag ttgttttgaa gcatctagtt 2531821 tgtgtccgct gtgcatcagc gacgtttaat aatataacac ctgtatttat ttattgcaat 2531881 agttttttaa aaaaaatcta taaaacaaat aaactataat cctcgccatg atttctaaag 2531941 cgtgtgtatc atataagttt cttaaaagaa catatacatc agtcatgtga tcttgttgtt 2532001 tttttcgttt tcttgtatag tagaaacgaa ctaaatactg atgaccacaa ggggagcatt 2532061 aaagctgaga gtgagcggtt tcgttctgac cctttgaacc tgttagttaa cgctggcgta 2532121 gggatgtggc aaagtcaaat gaattgcaga tcgtaaagca gtgcgtggaa cttttctcat 2532181 ccttccgcgt gctgcttttt tgttgtcctt ttggttgtct gtcaatggaa ggagatagat 2532241 atgaatcaat ctaagcaact ggttcgcctt attgaaattg ccattatgac agcggcagcc 2532301 gttattttag acattgtctc aggaatgttt cttagcatgc ctcaaggagg ctcggtctcc 2532361 atcatgatga ttccgatctt tttaatttcg tttcgctggg gtgtcaaagc aggtcttact 2532421 acaggtttgt tgacaggtct agtacaaata gcaatcggaa acttgtttgc tcaacatcct 2532481 gtacagctat tgttagatta cattgtcgct ttcgcagcaa tcggcataag cggctgtttc 2532541 gcttcttctg tccgtaaagc cgctgtatca aaaacaaaag ggaaattgat tgtttcagtg 2532601 gtcagcgcag tttttatcgg cagtttgctg cgctatgccg cgcatgtcat ttcaggagct 2532661 gtgtttttcg gcagctttgc tccaaaagga acaccggtat ggatttattc tttaacttat 2532721 aatgcgactt acatggttcc ttcattcatt atttgtgcaa ttgtcctatg tttattattt 2532781 atgacagcac cccgtctgct taaaagtgac aaagcgtaaa agtaacaatc ccccagcgaa 2532841 ttccgctggg ggatttttcg ttatctgtta agaagtgttt ttaaagctga aagatccggc 2532901 cagccaagac ctacttcttt cagccttact ccggcaattt caaagttgtc ctccgctact 2532961 ctttcaggtg aataggcctg ataaaatata atcgagggat tctgctcaat aacccaaaca 2533021 aacatacttg aaaaaccatg ttgaagcaaa aactccgctc cttttgctaa gagcgccctg 2533081 cctgcacctt gccgctggcg ctcttccaga agataaatag cgtataactc gccgtcatag 2533141 ccttcttgtt cagagcgaat aggtccaaat gaagcaaagc cgaatactga acccttttcg 2533201 tcctgagcaa caaatactcc ctttaacgag cgacttttcc atttgtcttc aaattcctta 2533261 tagttcaggc tgtttaaata atcaatcggg ataatttcgt ggtatgttgt cctccagctg 2533321 tctacatgca cttttgcaat gtcctttata tcctctaact tcgcttcacg tacagttacc 2533381 atacggttct gccctttcct tactctgatt tttggatcgt tttggcttct ttgatttcat 2533441 ttgttaattc attaatgctt tgttttacgt ttccttttcc tgaaaagttc tcaagcattt 2533501 cttttacatc aattcctgag gatgctttta aactttcttg cagacttgac attaagttcg 2533561 tcgcatagct ggttactttg tttgctccgc ttgattcacc gcttcctcct gtatcgacaa 2533621 cggtgatttt atcaatattt gaaagaggtg ccgctgcttg tttcgcgtat tccggaagca 2533681 ttttgacaat catatcgaaa atcgccgcct gcccgtactg ttcaaaggcg gccgcaattt 2533741 tctcttttgc ttccgcttct gcaagacctt tcaggcggat aacctctgct tctgtctctc 2533801 ctttcgcttt ttccgcttct gcttttgcta gcccgtcaat tcttactttt tccgcctcag 2533861 cctttgccat tgcttcaata ctgtacttct tggcatcggc ttccgcgagc tgtttggctt 2533921 tctcagctgc tgcggactgc tcaacagaat aacggtctgc atcggctttt ttctttacct 2533981 ctgagtcgta ttgacgttca cggcgaagaa tttctttttc ttctagttct atttgttttt 2534041 ggcgttcgat aattttaacc tgcatttcct gctctgtgac ttgctggcgc gctcgggcag 2534101 tctctaaatc atatgcttgg tcggcattcg cttttgccgt atcttgttct ctgcggaatt 2534161 cagccatttt gagctgattg attttttcag cttcagcgat ttccgtcgcc cgttcaagtt 2534221 ctgatttttt tgcgtcttta tcggcttctg cccgcttaat tcgggtttct ttatcagcct 2534281 ctgctgttgc gatatcagca tcgcgtttta cttgggcaat tctcggtttc cctaatgatt 2534341 caagataacc gtttttatca cgaacatctt taatggtaaa cgagacgatt acaagtccca 2534401 ttttcgcgag atcctgtgaa gcgacacgct gcacctcttg agagaatttt tctctgtttt 2534461 tatagatttc ttctactgtc attgagccga gaatggaacg aaggtggcct tctaaaacct 2534521 cccgcgcttc ctgctcacgg tcgtcttttg atttccctaa aaattgttcg gccgctgtag 2534581 cgatttctcc tatagaaccg ccgattttaa taatcgcagt tccatcggcc attactggca 2534641 ctccttgttc tgtatagact tcaggtgtcg aaacatcgag tttgcttgat aataggctta 2534701 gcggctctgc ctgctggaag acgggaagga caaaggttcc tccgccgcgg acgattttaa 2534761 tacggttgcc gccttcatcg acatgaacat ttttattacc cagatagctc cctgttacaa 2534821 ttaacgcttc atcaggccct gctgtacgat acttcgtaat aaacacagct attagtgcaa 2534881 ttaataaaaa gaatacaact ccgatgatca ttataatcgg cattgtcata tcaaattcct 2534941 ccttttatgt taaatgggtt catgcggagt aaccgaaaga actccgttgt taatatctac 2535001 gactaacacc gttgtcccgt aactgatctg ctgattatca aaactgaccg ctgactttga 2535061 aatggtcccg cctatccctt ctatgaccac ttcaccaaac ccgtcaaccg gcacagctgt 2535121 aatcacttta ccgagtcttc ctctgagatc atcttctcta tatgccaatg attcttctgc 2535181 agatgataat ggcaccagta caaagatgtg aagcaatacc accagcatga tcgaaaggat 2535241 gcaagataaa agcgcaatca gcaagcttga cagaggcaat acaagttcac ctatatatcc 2535301 gcccgctgaa aaacatgtaa aaaatgagag cactaatgtc ggattaagaa acggaatgcc 2535361 ttctgacagc cctgaaaata catctccgaa aaacaggaat aacagcgtaa ggctgcccgc 2535421 aataataagc gtataaagat acattgtttg tataggtact ccaaataact ccaacttcct 2535481 catcctttct tcatcaatgc attgatgaac ggctgccgtt accatttata cgagacacct 2535541 cgggaaaagt ttcaaaattt taagacaaat aacccatttg aagtgcttta taaatgataa 2535601 ttgcttatat atatggtaat gtcattttag gaggagatat gatgagtatc tttaatgaag 2535661 ccagattaga aacgtggaac gaattgaaag gactttctga cgaaaagctg aatcaaaagc 2535721 cttctgctga agaatggagc atacgggaag ttcttgacca tttgaaaaaa atcgatatga 2535781 ccgcacaaaa aatgttgaag gaacgtgtaa aggacgctcc gattaaagaa attgaagaaa 2535841 aaccgcttga agtagcacag gacagaaata ataaacggaa agccccgagt catcttgagc 2535901 ctgcgcatga ttttatttca ggcagccaaa tgaaacgtga gcttgatgtg gtaagagagc 2535961 agctgactgc tgcgattgcc tctctgaaag aagaagattt tgaaagagtg cttccgcatc 2536021 ctgtgtttca agagctgact gtcagacagt ggatcgattt tatcggccat catgaaaaac 2536081 ggcacctcag ccaaatgaaa gaaattaaag aaaagataga aagggcctga tttaatcaga 2536141 ccctttctgc ttttcgtttg acttttcgct gataggaatg aacttctatt tcatcacctg 2536201 tgtaaacagc accaggtctc tccacaatac agacaatccc tctaatgccc agtgcgtggc 2536261 ggacgaaagc cgacgccagc ttcggttggt ccggataata agactgaatg acttctcccg 2536321 gctggataca cggatcattt tcgccctcac acagcagagc cgctccgctc ggaaaaataa 2536381 tccggcttcc ttcttttaat gaagtaagat ctggcatacc gctgactgcc acattcgccc 2536441 cgagccattc cggcaaaatt ctcggcactc ccatttttaa agcgatttcg ttgcattcct 2536501 ctattgaaac aattgaaatt tgtctgcggt tgaaaatttc agtccctctt gaaaacattg 2536561 gttctctggc tcccgctttt ttggtcaggc caaaatgcaa gtcgccgggg atgccgccat 2536621 aatcaaaatc aagcttgtcc atttgctttg ttacgaagct ttttgtatct gcgatatata 2536681 agccttccgc ttttgcagtc atacgcttcc acatcagctg gcaccttcct tcttatctaa 2536741 aatttccacc tatgcttcat tatcccaaaa aatcccgctc tgtaaaggag cgggattttg 2536801 attataccgt tttaggcgta aggttaaagc agcgtttgta gatccagttg tatgcttttt 2536861 catttaaatc tctagggttt ccgaaggttt gcggatcttt cattgcttct ttagacaagc 2536921 gttcgatcat atcaggtgat actccctgct cttctaaagt cggcacttct aaatcttcga 2536981 ccagatcata catccaattg acagatgctt tcgcagcttc ttctgttgtc atcttgcttg 2537041 tatcaatacc gaacgctttc gcaatacgcg caaacttctc aggatagccc ttccagttgt 2537101 attccatgac agggcccatc atcgccgcta cacattggcc gtgagcgact gggataatac 2537161 cgccaagcgt ttggctcatc gcatgagcag cgcccgctga ttcacttccg taagaaagac 2537221 cggcaagcat cgcagcctgc gccattccgt accttgcttc cagatcctct ccatcagcaa 2537281 atgccctctt gatgtaatga gcggcatact caatcgccat taaggcaacc gcatccgtga 2537341 ttggctgtgc aaatttcatt gtatagcact caatggcatg ggcgagcgca tcaattcccg 2537401 tcatagctgt tacatgcgga ggcattgaaa catgaagctc aggatcaatg attgtcaagt 2537461 gcgctgcaat cagcggaccg cccgtgttga atttgaattc tctttcttca tctgtgataa 2537521 ccgcccattg ggttacttct gatccggttc cagctgtagt gggaattgtc gtcagcggag 2537581 gaatgcggtt ttccagcggt tttttcccat ctgccgcttc ataatcaagc acgcttcctt 2537641 cgtgagtcgc ttctactccg attgcttttg ctgtatccat ggagcttccg cctccgactg 2537701 ccaccaaacc attacagttc tcttttttgt aaagctcaga tccttcattc accagacgga 2537761 caggcgggtt tggctcaact ttattaaaga gtaccacttc aatgcctgct tctttaagtg 2537821 attcgattac gggatcagca acaccggctt tataaatccc agggtctgtg acaaggagcg 2537881 cttttgaaac gcccagtgca gctacttcct cacccgtatg cttgatggct ccgattccat 2537941 gcttaatcac agtcggaatt tcaaatgtgt ggaatttctg catgctttct accttcatat 2538001 ttaatgtcat catcaatctc cccctcttat gaattaaacc agttaaccgc tgccggtttt 2538061 gtattgcggt atacatgttt gacttctgtg tattcttcaa ggcctatttt tccaagctcg 2538121 cgtccgaacc cggattgctt atatccgccc catggcgctt gtgcaaagta cggatgaaaa 2538181 tcgttgatcc aaacggttcc cattctcaag cgggctgcta cccgttcgca cttttcaatg 2538241 tcttttgacc ataccgctcc agccaagcca tagatggtat cattcgcaag ctcgattacc 2538301 tcttcttcag agctgaaggt ttcgactgtc aatacaggac cgaaaacctc ttcctgaacg 2538361 attctcatgt cagaattaca gtttgagaaa atagtaggtt catagaaaaa gccgttttga 2538421 agctcaggat cttccgggcg tttgcctcct gtctccagct tcgcgccttc ctctattccg 2538481 atctctacat atttttctac ctttgccctg tgctccgccg aaataagcgg accgctttct 2538541 gtctcagcat gaaaaccgtt tccgagtttt atgcgttttg cccgtttgac cagctccgcc 2538601 aaaaattgat catgaatggc atcctcaaca agcaagcggg aacctgcaga gcatacttgg 2538661 ccggcgtgga aaaatacagc gtttaaggcc tgatcaaccg caacttctaa atccgcgtcc 2538721 ttgaaaacaa tatttgggtt tttcccgcca agttcaaggg cgattttttt gacgtttccg 2538781 cttgccgccc gcatgatttt tttgcctgtt tcaattccgc ccgtaaatga aatcaaatcg 2538841 acgtctttgt ttacggcaag ctcgtcgccc actgtggctc ccggtccaag aacaagattt 2538901 gcgacacctt ttggaacacc ggcttcttcc atcagcttaa agactttgat tgtcgtcagc 2538961 ggcgtaatct cactcggctt catgacgatt gtgtttcctg cggccagtgc aggggcgatt 2539021 ttccagctcg cttgaaggag cggataattc catggagtga tctggccgca aaccccgatt 2539081 ggctccctaa taattttgct ttctgaatca ggaatcggag atgaaatgat ctctccgcca 2539141 tctttgtctg ccaagccggc gtaatattga aaaacattgg cgatatcgtc catatcggcc 2539201 ttgctttctt cgagtgtttt tcctgtatca agagattcaa gctcagccag ctcctcaaga 2539261 tcgcgtctga ttaattccgc aattttcaga acaatttttc cgcgttcaag cccggatagc 2539321 gatgaccatt ctcctttgtc aaatgctcta cgtgcggctg cgattgcttt gatggcgtcc 2539381 tctcgccctc cctcgcttac agttgcaatt tcttcttgat taaatgggtt gataatactg 2539441 cggatctgtt ctttttcggc actgatccat tctccgtcaa tgaataatgt ttgactcata 2539501 taagcctcct tgacgtaaat aaagtttgtt aaataaaaat ttaatgtttt taacaacctt 2539561 aatctaacat atggttttta aactgtcaaa gtcccatttt gatttttctt tttgactttt 2539621 cctcatgttt cgttaagata aagaacataa agaaataact taacgaattt aattttctaa 2539681 aggaaaagag ggtcagtatg gatgaaaatc cagaatttgc agctatagaa caggctcggg 2539741 atcttgttat tgactccatt gctgaaacga tggatcttta cggaattacc cgcagtgtcg 2539801 ggattttata tgggacgatg tatatgaggg atgagatgac gcttgacgaa atgcgtgagg 2539861 agttgcaaat gagcaaacca agcatgagca ctggcgtcaa aaagcttcaa gacttaaatg 2539921 tagtgaaaaa aacatttcac cggggcatcc gcaagcatac atttgtggct gagaaggatt 2539981 tctttaaatt tttcacaaat ttctttccac ctaaatggga gcgggaggtt caagtgaatg 2540041 taacagcgat cgaggaagct caagctgatt tacaaaaggt tttatgcaag gaagatctcg 2540101 atgaggatat caaaaatgaa gcactgcagt tatatgatca gctggaaagc tctaaagctt 2540161 actatgactg gctgaaacgg cttgctgaat cggtgcagac cggagaaatt tttaaattta 2540221 taccggtcga aacaaagtaa agcagaaaac gcctgggaaa ctaggcgttt ttttgatgta 2540281 actactacaa atttgaaaaa tacgggaaaa acaccccatt tacttccaaa atatttgatg 2540341 gtaattttat gtaggtaaaa tttgtatttg gcctttcaga ggaggtgaaa agcgggcagg 2540401 cctgtttaat ttatcatttt ttagggggaa ttttgttatg aaacgcaaat tattatcttc 2540461 tttggcaatt agtgcattaa gtctcgggtt actcgtttct gcacctacag cttctttcgc 2540521 ggctgaatct acatcaacta aagctcatac tgaatccact atgagaacac agtctacagc 2540581 ttcattgttc gcaacaatca ctggcgccag caaaacggaa tggtctttct cagatatcga 2540641 attgacttac cgtccaaaca cgcttctcag ccttggcgtt atggagttta cattgccaag 2540701 cggatttact gcaaacacga aagacacatt gaacggaaat gccttgcgta caacacagat 2540761 cctcaataac gggaaaacag taagagttcc tttggcactt gatttgttag gagctggcga 2540821 attcaaatta aaactgaata acaaaacact tcctgccgct ggtacatata ctttccgtgc 2540881 ggagaataaa tcattaagca tcggaaataa attttacgca gaagccagca ttgacgtggc 2540941 taagcgcagc actcctccga ctcagccttg cggttgcaac taatgtaaaa gaccggttaa 2541001 cgccggtctt ttttgcgttt taccctcccc tttttctcta atccccgtta tcttttttct 2541061 ggtttaaaat ttaaattgac aaacactaga aacaggagta aattcttgag tgttcaattt 2541121 catacagtct cttttaccgc ttaatcaaac acgaacgggg gaaccaacga ttggctgttt 2541181 tattaacagc cttggggtga atcttactaa gtaagagggg gtactctgaa tccctaatcc 2541241 gacagctaac ctcgtaggcg tatacagaga ggaggtctat tatcggccat tctttgcaat 2541301 ggtctttttt gtttcaaaaa cgttaattca ctaagggaga tatgaacatt gggaagaatt 2541361 aaaaataagc aatttgccgt gatcgggctg ggccggtttg gcggcagcat ttgtaaagaa 2541421 cttcatagaa tggggcatga ggtccttgcg gttgatatca acgaagaaaa ggtcaatgca 2541481 tatgcttctt acgccactca tgcggtaatt gccaacgcca ccgaagaaaa cgaattgctt 2541541 tcattaggaa tacgcaattt tgaatatgtg attgttgcca tcggagcaaa tattcaagcg 2541601 agtacgctga ccaccctatt attaaaggag cttgatattc caaatatttg ggtgaaggct 2541661 caaaactatt atcatcacaa ggtgcttgaa aaaataggcg ctgaccgcat tattcatcct 2541721 gaaaaagata tgggggttaa aatcgcacaa agcctttcag acgaaaatgt tttgaattac 2541781 attgatctat ctgatgaata cagtattgtc gagctgctgg ctacgcgcaa gcttgattca 2541841 aaatcgatta ttgacctgaa tgtaagagca aagtacggct gcacgatcct ggccattaaa 2541901 catcatggag atatctgtct ttcccccgcg cctgaagaca tcattcgcga gcaagattgc 2541961 ctggtgatca tgggccacaa aaaggatatt aaacgttttg aaaacgaagg gatgtagaca 2542021 aaggtgacac ttcaaaagga taaagtgatc aaatgggttc ggtttacacc gcctcaagtg 2542081 cttgccattg gttttttcct taccattatc atcggggctg tcctattaat gcttccgatt 2542141 tccactacga agccattgtc atggatagat gcccttttta ctgcggcttc cgctacaact 2542201 gttacagggc ttgctgttgt cgataccggc actcaattta cggtattcgg gcaaacagta 2542261 attatggggc tgattcagat tggcgggctt ggatttatga catttgcggt cttgatcgtc 2542321 atgatattag gaaaaaaaat cggcttaaaa gaacgaatgc tcgtccagga agccttaaac 2542381 cagccgacaa tcggcggtgt cattggcctt gtcaaagtcc tgtttctgtt ttcgatcagt 2542441 attgaattga tagcagcact cattttatcc atccggcttg tacctcaata cggctggtca 2542501 tccggcttgt ttgcaagttt gtttcacgca atatctgctt ttaacaatgc cgggttttcg 2542561 ttgtggcctg ataatttgat gagctacgtt ggcgatccta cagtgaacct cgtgattact 2542621 ttcttattta ttacaggagg gatcggattt acggttctgt ttgatgtgat gaaaaatcgg 2542681 cgttttaaaa ctttttcttt acatacaaag ctcatgctta caggaacgct gatgttgaat 2542741 gcgatcgcta tgcttacggt ctttatttta gaatacagca accccggcac gctcggccac 2542801 ctgcatatag tggataaact gtgggcctcc tattttcagg cagtgacgcc gagaaccgca 2542861 gggttcaatt ctctagattt tggaagcatg agagaaggaa caattgtatt tactttatta 2542921 ttgatgttta tcggagcagg aagcgcatca acggcgagcg gcattaagct gactacgttc 2542981 atcgtgattt taacatctgt tattgcttac ttgagaggta aaaaagaaac ggttattttc 2543041 cgccgttcca tcaaatatcc gattatcatt aaagctttag ctgtgagcgt caccagtttg 2543101 ttcatcgtgt ttttagggat tttcgccctg acgatcacag aacaagcgcc atttcttcaa 2543161 attgtgtttg aaaccttttc cgcattcgga actgtcggcc ttacgatggg gcttactcct 2543221 gaactgacaa cagctggcaa gtgtatcatc attgtcatca tgtttatcgg aagaattggt 2543281 cctttaacgt tcgtgttttc attcgcaaaa acagagcaat caaatatccg ttatcctgat 2543341 ggcgaagtgt ttacagggtg atatcaaaaa aatccggcgt gcagtcgccg gattttttat 2543401 gattcgatat gagattgatt ttgtcttttt tcctgttccg cgatgatttc gttatcctcc 2543461 gcgttatcac gggtcacttt ttgcgtaaga atcgcaccaa ctgctacaag tatcataaca 2543521 gcgatgtaat aacctttttc attgagttcc agattatcag cattatagag tccgatacta 2543581 aacaaaaata ctcccgcaaa aaaagtaaaa taagctagta ctgtaaaggc aaccgtgttt 2543641 ctgcgtctat atttctgcac ctttgttccc tcccgaaagc atagttaaaa agtgataact 2543701 tccgtggaat attatacctc aaattccccg gaatggaaca aagaattaaa aataccagta 2543761 aaaagggctt aggttgcctc ctttatttca acagctgaat catcaatcca gccgataagt 2543821 ttatcattga tttggaattg gtaccataca gactggcctt tctgtttttt agacacaacc 2543881 tttatgtctt tgccgacgta agattgggca gaggtaagcc ttatggaccg atcatcagta 2543941 gaaggcttgg accatacgtc ttgaacggca ctgtctttaa tagaggcgtt taaatccaca 2544001 gatttgaggg atggatttac ctcatcgtac tcatctaaat cgtatttttc cacaatagcg 2544061 ctgattttgt cagcgtagtc agggtctgta gcatatcctg atgtttgcag ggcggttgcc 2544121 gcttccttat aattccctgc ctcaagcacc ggtttatact tctttttatt ccacgatgtg 2544181 ccacggacga acaattgggc gtgatcatcc atagattcaa aaaacgtgct gtattttcga 2544241 aacttcgcgc gaatggtttt tcttttccct ttttcaactt cgtccgtttc catcgtgaca 2544301 tgatggcctt tataattccc ttttacgcca aaaaggttgt tggccttagc agccagttca 2544361 ctgttccccc agtccgattc gagaatggcc tgagcaattg tgatgctggg gagaacatgg 2544421 tatttttcat acaaaatttg ggcatgtccg gacagactgt ctataaatac ttgctgttca 2544481 tcgatttctt cagtttcttt ggatatttca atcggttttg ataaagttgt cgctaaaaca 2544541 aacagagcta gcggaatcga tacaaggaaa aatagtgaaa tcaagagttt acgtttttta 2544601 agttttttac gggccatgaa aaccttcctt cgaattaaaa gattacgaat gtaaaagaat 2544661 ctacctttta gaattttact tgcacttcta atatttttca attctttagg gataaagttg 2544721 ggaaaagatt gcaaaataaa aaccttttcg ctcaatgaaa aggtttttac catgtttcta 2544781 tttttgtaaa tttctgagtg cattccgata ttccgtatca tttattactt tatatgattt 2544841 gacagttgcc ttcgacaaac cttgtgctga gacggccggt ttttccggag ctgttttcgc 2544901 tttatcatgt ggtttatgtg ccagcttgtg ccccattcca gtggcattca tacaaaatga 2544961 caggcagacg agcagcacgc taaggataaa agaaatgaag aagagatcat gataagcagt 2545021 catcatagaa tcctgtaccg aaccgctttg tctggcagca tcttttttcg tgaaaaagcc 2545081 gatgagaatg ggaactccca tatagacaaa caatcttaaa aactgaacag ctgtcattct 2545141 cttgaccaaa tcaggcagcg ggcctcccat ggcagctccc atcagccctg cggcgactgt 2545201 caggcctgtt cccgctgcaa gcatgataaa cagtgccgcg aacatataaa gagatgatcg 2545261 atcctgtata tgcagccatt gaaaattcac aaaaacgaga atgagtccgc cgataatacc 2545321 gagcatccct ggtccgactt tatcgtataa cagagcgctc aaaatggccg cgatcgccac 2545381 tccgattaaa agagtcaagc ttaaaagaat gagatgctcc tgagaaatat catacatttg 2545441 acggagcaag ccttgaaaag cagaaaggct gacagctacc gttatcgtcc ctgcagctat 2545501 gatcaataag ccgagcaccg gttttggcag cagcatcagt ttaatagata tgaaggggtt 2545561 tttcacttta tattccacaa tcaatagacc aatgagcaaa cataacgtca ccccgaaacc 2545621 aatccataca taacccgatg acagccccca tttttgcaga aaaatgaatg aaaccgctga 2545681 ggctgcggca aggaagacag ataaaagaat tcccgcacga tcaagcggct gttcttgatc 2545741 cgccgctccg tgatgctcat catgaagaaa gaaatagctc accgcgacac cgatcaggga 2545801 caaggtgcca aagatgaaaa acagccatct ccaatgcccg cagcttgttg caatggttcc 2545861 caggattgta ccgatgataa cagaaccata gaatcccccg atcagcacaa gcagtgcata 2545921 gttcctgcgt tcaatcggga atgacagtac aagcattgga atcataatca tcagcatgac 2545981 gcctgttgcc gccccttgta aaaagcgccc tgccgccatc aatgcaatat cgcctgaaca 2546041 tgcgatgagc agtgagccta gtataaagac aggtaatgaa gccagataga cgggacgagc 2546101 accgaatttt ttcctcagca gcggtcctgc cggaactaac aaggcaaagg ccatattgcc 2546161 gatcaatatc ggatttactg atgtaaagac acttgttcca accgttttct gaacaaggcc 2546221 ttgaactgac gacaatgccg tgttagacat caatcccggc ccgaccgcta agacggcgag 2546281 caaagaaatc acccaatagt gttttgtctt catgttgtca tcccttccta tatgaataca 2546341 tgcgaaacac atcatttttt gaaaacaaaa gaagctaata gattttgcat accattagct 2546401 ttcattctaa tattctccct ttcaggggaa atgatattat tttattataa ttatgtgaat 2546461 gaatgagcat ataatcaaat attatttcaa atcgattgtg ttttgtcaat ggagtaaatt 2546521 tcaagcacaa catagaaagc ttgaaagctt ttccccgata ttgtgtctag aactgcactt 2546581 atgaatccct gctcgttccc tcaagcgaat taaagcaggc cgttttaatc ctttcaatcc 2546641 actattccaa ctaataaact caaataagtt ggtgataaga caacatttta cccccacatt 2546701 tttttgtgtt cactgggcgt ttgccgcctc taaattgtat atgggtaaat accatgaatt 2546761 aacctatgaa ataccaatgt aagggaggca aaaacgaatg gaactgtatg agtgtatcca 2546821 agacattttt ggcggcttga aaaatccatc ggttaaagat ttagcaacgt ctttaaaaca 2546881 aattccaaac gcagcaaaat tgagtcaacc gtatattaag gaaccagacc agtacgctta 2546941 cggccgaaat gccatctatc gaaataatga attggaaatt atcgtgatta acattccgcc 2547001 aaacaaggag acaacagtac acgatcatgg tcaatccatt ggttgtgcaa tggtgttaga 2547061 aggaaagctt cttaattcta tttatcgttc aaccggcgaa cacgcagaac tctccaattc 2547121 atactttgtc cacgaaggag aatgccttat ttcaaccaaa ggtttaattc acaaaatgtc 2547181 caatccaaca tctgaacgaa tggtgtctct tcatgtctac tcccctcctt tggaagacat 2547241 gacggtcttt gaggaacaaa aggaggtatt ggaaaattca tgattgacag ataaactgct 2547301 cactttgact tcactcaact ggaggattca gagaatgaaa ccttttcctc aaaacaaaaa 2547361 aacccttatc gaataagggt ttaaaggtat ggagccaagg gggctcgaac ccctgacctc 2547421 tacgctgcca gcgtagcgct ctcccagctg agctatggcc ccgtatgtaa cgtcatgttt 2547481 attatagatg attttatttt gaaaaacaag ctgtttcctc ttgaattgac agaaaaaata 2547541 aggctcggaa aagagcctta tttttcgact tacatcatga tcaaaagtaa aatcacaccg 2547601 agaataattc gatagattgc aaatgggaca agtttgattt tgttaatcag ccttaagaag 2547661 aaacggacga caaacagtgc gaccacaaag gcacagataa agccgacgat gaaaaacggc 2547721 atcagatccg aacttaagct gtcccaatgc ttcacgaggc ttagaaagct ggctcccatc 2547781 atgatcggca tcgccataat aaacgtaaag tcggctgcag ctcggtggtt taatccgaga 2547841 ataacaccgc cggaaatggt tgaacccgaa cgcgagaaac caggccaaag ggaaagacat 2547901 tggaataagc cgacggctat cgcctgttta taggaaatgc ggtcgagtgt gtctgtcgct 2547961 gttttccgtt tattgaccca gtcagcaaaa agcatgagga ttgccccggc aattaaaccg 2548021 atggccacag ttttaacgga aaataaatat tcatcaatgt aatcttcaaa caaaaagccg 2548081 agaacagctg caggcacgag tccgacggca atttgggcaa tgcttaattt atgtccctgc 2548141 tcctggtcgc ttgtaatatt ttttttcaag cccagtaaat ttaaaattcg gtctttaaac 2548201 acgatagcta ctgctaaaat ggagcctagc tgaataacca ccttgaatga gttagcagct 2548261 tcttctgaca tcagattact tgattttagc cagatgtcgt ctactatgat catatgtcct 2548321 gtcgaagaaa ccggcgcgta ctctgttaat ccttctacga ttcctaaaat ggcggctaca 2548381 aacaattccc atagagtcat gattttgatt ctccccatta gacatttatt tttttacata 2548441 acgggagctt cccataaatg gaaagcccgt cttatataac tataaacgaa aatcacactt 2548501 tatgccccgg cgtattttca tttttttctt catcgtataa atgtgactgc attttaaacc 2548561 agtcaaataa atgtgtcgta atgactttgg caaccgcata gccgggaatc gcaagaatga 2548621 ttccaacaac gccaaacagc ttgccggctg ttaacagcag aaaaataatc gtaatcggat 2548681 ggatgtgaag gttttttccc ataatttgcg gagagatcag cttcccttca atcagctgaa 2548741 caatcgtcca aacgatcacc agcttaagca gcatgagcgg cgatgtcact atggcaatga 2548801 taatcgcagg cgtaatggca atcgttggcc ctaaatatgg aacgatgctt gtgcaagccg 2548861 caatgactgc aagcaatgaa gcataatcca gcccgataat caaataaccg ataaacagca 2548921 aaaacccgat acagaagctg acaatgatct ggcctctgat ataagagctt aaccgatgat 2548981 tcatttcgct taagactgta tatgtctgtt ctttcaatcg agtcggcaca aacttcagta 2549041 tgtagaccgg taattttctt ccgtctttta gcaaataaaa tagaataaac ggaaccgtga 2549101 cgatcgaaat gataatctca gtcagtgcgc cgataaaatt cccaacaccg gtaaaggtgc 2549161 tgttcacgat cgtcgctgcc tgatccgaaa cctttgtagc aagatcagat atattaatgt 2549221 tcatcgtttg ctgggcctga ttgacgaagt tgctgccaat cagctgtttc gtctgatttt 2549281 ctacgacgtc cacatatctc gggatattgt caatcaaact cataatttgt tcttttaaga 2549341 agggaatgat cgacacgatc gtgatcgtga tcagcccgat aaccaatagg tatagcagca 2549401 atatagaata gattcttctt attcttcttc tctccagaaa atcgacgact gggtttaaca 2549461 gataaaaaac aatgcctgtc aaaataatcg gaagtgatat cgttttgagc agaacaataa 2549521 tcggggtgaa aataaatgat gtttttgtaa atactagaat atttaaacca atcagcagca 2549581 gcacaagcaa aaataaaaca aacttattat ccaagaagaa tcgcttgaat ctgccgctcc 2549641 atgtttgcaa cgtctccact atcgttcctc cgtcatacat agtttaatta aattgtacac 2549701 tatcgtccct ataatgaaaa ataaaaaccg ttaattgctg gaaaagcttt ctcggtttta 2549761 acattctatt tatatctatc atgtgatttt gttcttttta agctataatt tagctatatc 2549821 atgcaaaagg agcgatacga gtgatacgtt ttgcaataat aggaaccaac tggattacag 2549881 accgctttct tgagtcagca gcggatatcg aagattttca gctgactgct gtttattcaa 2549941 gatcggctga acgcgctggc gagtttgctg ctaaacacaa cgctgcgcat gccttctcag 2550001 accttcagga aatggcggcg agcgattgct ttgatgccgt atacatagcg agcccgaacg 2550061 ctcttcacaa ggaacaagcc gttctcttta tgaaccatgg caagcatgtg ctttgtgaga 2550121 agccgtttgc ttcgaataca aaagaaacag aagagatgat ctcagcggct aaggcaaacg 2550181 gcgttgttct catggaagca atgaagacca ctttcctgcc gaatttcaaa gaactgaaaa 2550241 aacacctgca taaaatcggc actgtccgca gatttaccgc aagctactgc cagtattcct 2550301 cacgatatga cgcgttcaga agcggaactg ttttgaatgc gtttcagcct gagctttcca 2550361 atgggtcatt aatggatatt ggcgtctatt gtatttatcc ggctgttgtg ttgtttggcg 2550421 cgccgaagga tgtaaaagca aacggatatg ctttatcctc cggagtggac ggagaaggaa 2550481 ctgtcattct gtcttacgac gggttcgaag ctgttctgat gcattccaaa atctctactt 2550541 cctatgcccc ggctgaaatc cagggtgaag acgggacgat tgtaatcgat acgattcacc 2550601 ggcctgaacg tgttgaaatc cgctaccggg acggccgcct tgaaaacatc gcgatccctg 2550661 atcctaaacc ggcgatgttc tatgaagcag aagaatttgt cacgcttata aaagagaata 2550721 agctggaatc tgaagaaaat acatttgaac ggtctttgac caccgcaaaa attatggaag 2550781 aagcaagaaa gcaaatgggg attgtatacc ctgctgatca agcgaattca tgccagtcag 2550841 ctttctcaca ttaatcttcc agacgttttt caagctctgc ttttttctct tcaaagccag 2550901 gtttgccgag taacgcaaac atattgactt tatacgcttc tacaccaggc tggtcaaacg 2550961 gattgacgcc aaggaggtaa ccgctcatcg cgcaggcttt ttcgaagaaa tatacaaggt 2551021 atccaaaagt atatgcattc agctcaggaa tgttaacgat taagttcgga acatttccgt 2551081 ctgtatgggc aagcattgta ccttggaatg cttttttgtt aacgaaatca acagttttac 2551141 cggctaaata gttcaagccg tcaagatcgt tatccgcttc ctcaattgtc agttcatgtt 2551201 taggcttctc tacgttcagg accgtttcga ataaatctct gcggccttct tgtacatact 2551261 ggcctaaaga atgaaggtct gttgaatagt tcgctgaaga aggataaatg cccttctcat 2551321 ctttcccttc gctttctccg aacagctgct tccaccattc cgcaaagtat tgaagcgccg 2551381 gttcgtagtt gatgagcatt tcaattgttt tgcccttatt ataaaggaca ttgcgaacaa 2551441 ccgcatattg gtatgctggg ttatcttcca gttcagatgt tgcaaaatct ttgctcgcat 2551501 ccagggcgcc tttcatcatg tcgtcaatgt tgacgccgct gacagcaatc ggcaagagac 2551561 ctacagctgt taaaactgaa taacggccgc cgacatcgtc aggaattacg aatgattcaa 2551621 agccttcttc gttagaaagc gtttttaatg cgccgcgctc tttatcagtt gttgcataaa 2551681 tccgcgcttt cgcttcttct ttaccgtatt tctcttcaag aagcttgcgg aaaatacgga 2551741 aagcgattgc aggttcagtt gtcgtacctg atttagaaat cacattaata gagaagtcaa 2551801 catcttcaag aagatccatg acgtctctca tataagatga actgatgttg ttcccgataa 2551861 aaatgacttg cggattgccg cgttttgctt ttggcaaagt gttataaaac gcgtgattca 2551921 gcgcttcaat cgctgcccgc gctccaagat aagaaccgcc gatgccgaca acaagcaaga 2551981 catcagagtc agatttgatt ttttccgcgc tttttttgat gcgcgcgaat tcttctttat 2552041 cataatgttc agggaggtcc acccagccta gaaaatcgct gcccgcgcct gttttctcat 2552101 ggatattatg gtgtgctgtt tttacaaagt cccgcaggta tgtaagttca tgttcgttga 2552161 agaaagtcaa cgcttttgag tagtcaaagc gtacatgcgt cattgcttgt ccctccataa 2552221 cggtataatg ttttcatctt tcactttata tgaacttatc tgtgaaatca agtcaagaag 2552281 aaagggcgga atgactggat tccgcccttt gggtttatag agacgcgcga aggatggcaa 2552341 gcacgtcatc tttgttcagt ttttggaagt tgccgaagcc gccgtgttcc atttccttgg 2552401 ctgcgatatc agcaatcagc tcaagctttt cttctccaat attgtaatca gcaagacgag 2552461 aaggtgcacc gaggcttgtc cagaacgcag acagtttatc gattccttca agcgcaattt 2552521 ctttatctgt tttgccttca gtatcaatgt caaacatgtt gagcataagg tttttaaaac 2552581 ggcctacatt tgtatcaagc gtgtatctca tccaatttgg gaacagtatt gccaaaccgc 2552641 ccgcgtgcgg aatatcatat acagctgaaa cagcgtgttc cattgtatga gaagcccagt 2552701 caccgaagta tcccatttgg agcgtgccgt ttaaagcaat agtaccagca tacaaaatcg 2552761 tttcacgaag ttcgtagttt tccagatctt caagaagctt aggagctgtt tcgatgaccg 2552821 tctgcaaaac agcaaagcac attctatcct gaagcggcgt gttttcaaca ttatggaagt 2552881 attgttcgaa tacgtggctc atcatgtcaa ccatgccgta tactgtttga ttttctggaa 2552941 cggtgaacgt attttcaggg tctaaaatag agaaacgcgg atgagtgaca ttgctgcccc 2553001 atacaaattt ctcgtttgtt tcccagtttg taatcacgga atcagggttc atttcagacc 2553061 ctgttgcagc aagagttaaa acagtgccaa acggcagcgc atcctccgct gttacttttt 2553121 tgctgaaaat atcccaagcg tcaccgtcat atttgacgcc agctgcgatt gcctttgtac 2553181 agtcaatcac actgcctccg ccgacagcaa gcagaaaatc aatgtcatgc tctctgcaaa 2553241 gtcctatgcc tttttccact gtcgcaagac gcgggtttgg ctctacacct gacagctcat 2553301 gaacaacagc gccctcttct tttaaaatgc ctgtgacttg atcataaagg ccgttgcgtt 2553361 taatgctgcc gcccccgtaa acaagcagta cattcttgcc gtatcgtttg aattcttttc 2553421 ttaattgttc aagctgacct tttccaaaaa tcagctttgt cggattataa taagtgaaat 2553481 tttccatagt aaaacctcca aatgatgctg gtaaaaaaca gattttccat tgtaacataa 2553541 gttgacaaaa aagaaaaagg gaagcagcca aacggctatt tccccttttt ttatagtgat 2553601 gctttcaaaa ttgacagcac atcttctttg ttgagtgatt taaattggcc gaatgtaccg 2553661 ttagccattg ccttgtcagc gattgtgtca agctgctcat cattaatatc ataatcagca 2553721 agacggttcg gagcgccaag acttgtccag aatgcggaca gcttatcgat accttcaagg 2553781 gcaatttctt catccgtttt acctgcttct tcaacatcaa acacgcgaac tgcaagctgt 2553841 ttcatgcggg cagggttttc agacaatgtg tgtctcatcc aattcgggaa cagaatcgcc 2553901 agtccgccgg catgcggaat atcataaacg gctgatactg catgttcaat attatgagta 2553961 gcccaatccc ctcttgcccc catagaaagc atgccgttta atgcgattgt tcctgtgtac 2554021 aggatcgtct cacgcaattc gtaattttcg agatcattga tcagcttagg cgctgtttca 2554081 atgactgtac gcaaaagtga ttcacacatg cggtcctgat acggcgtgtt tgatacatga 2554141 tggaagtatt gttcgaatac gtggctcatc atgtcaacca tcccgtagat cgtgtggttt 2554201 ttaggtacgg tgaatgtatt caccggatca agaatcgaga atttagggaa tacgagcggg 2554261 ctgccccagc cgtatttttc ttttgtttcc cagtttgtaa taacagatcc tgagttcatt 2554321 tctgaaccag ttgcagcgag agtcaatacc gttccgaatg gcaaagcatc ttttggctga 2554381 tgctttttcg taacgatatc ccacgcatca ccatcatact tcgctcctgc ggcaatcgct 2554441 tttgtacagt cgattacgct tccgcctccg acagccagca agaaatcaat gttttgttct 2554501 ttacagatgg caacaccttt attaacagtc gacacacgag gattcggttc cacacctgct 2554561 aattcatgca cggtcgctcc ggctttattc agctgttcaa tcacttgatc atacaggccg 2554621 ctgcgtttaa tgctgccgcc tccgtacaca agcaatacgt tttttccgta aggtttgagt 2554681 tcctccggaa gtctttccac ttcgccgcgc ccgaaaatta atttggtcgg attccagtat 2554741 gtaaagtttt gcatgacatc tcctccttag attttttatt atgcagaatg tcctcaccac 2554801 atgtaaagca atcagctctc accgatcagc ataccagatg gttttatttt gcaaggtgct 2554861 gggaaagaag ctgatataag cgagggcagg ccagcttccc tcatatggag aatgcatgta 2554921 tagattctcc aatatgtcac aatctataac tgttttaata attcatggag gaggttgcaa 2554981 aacatgagta ccattcaaag aatttgtctt gtattaacca tcattggcgc cattaactgg 2555041 ggactgatcg gatttttcca atttgactta gtagcggcta tcttcggcgg ccaagggtca 2555101 gctctttccc gaatcattta cggacttgtc ggaatcgccg gcttaatcaa cctcggtctg 2555161 ctatttaagc caaacgagga aagatcacgt gaagaagcag caaatcctga aatgcgatag 2555221 gatatcaatc acgctgaaat aggattttgc atgaaatcaa aagcaccgaa cattcctgtc 2555281 cggtgctttt ttcatgctta ttttttgata aggtctttgc ggttggacat ttcgatccac 2555341 tcttcaagct tatcttttaa tgtgttgaaa ccttgtggtg tagaagcttc ttcgcttact 2555401 tgagcagctt taggttttct tggtttgctt tcttttttct caggcgcagc ttgtgtcgca 2555461 cgaattgaaa ggctgatttt gcctttttct tcatcaacag caagtacttt tacttgtact 2555521 tcgtcgccaa ctgaaaggtg ctcgttgata tcttttacga aaccgtgagt cacttcagaa 2555581 atgtgtacta aaccttgagt ttcttcatct aatgcaacaa acgcaccata cgcttgtaat 2555641 cctgtaactt taccagtgta aacactgccc acttcaaatt ttgctgccat tcataacaac 2555701 tcctaagtta aattaaatat ctgtttatac gcaatttaaa attatatcac acatgtctta 2555761 tttccgcaaa gaaaactttt ttataaaaaa tcaggtttat gcacagcaaa aagggggtaa 2555821 actgaaaata ccaaaggctt tctagtattc ccccctttta ttggatgcga acaaaaggtt 2555881 cgtatctttt tttatgttgt tttgtgcagg aagcgtttca ttctgactaa cgcttcttga 2555941 agctgttcaa tcgaggttgc gtatgaacaa cggatatatc cctcaccgct cggaccaaac 2556001 acacttccag gaacaactgc cactttttcc tgcgtcagta gctcctcggc aaactgttct 2556061 gaactcattc ccatgctttt gatagatgga aaagcataga aagcgccgcc cggatgatga 2556121 cagctgagac cgatttcatt gagcgattct acaaacagat tccgtcttct tcgatagctt 2556181 tttttcattt tttctacgtc ttccatgccg ttcttcaggc cttcaagggc ggcaaactgc 2556241 gccattgcgg gcgcgcacat catcgcatac tgatgaattt taagcatggc atcccgaagc 2556301 aaggatggtg ccgcggcaaa accgagcctc cagcccgtca ttgcaaatgc ttttgaaaag 2556361 cctgagatga ctaccgtccg ttccttcatt cccggtaatg ccgctatact tgtaaattcc 2556421 tcatcatatg tcagctccgc gtagatctcg tcggctaaga cgatgacatc atgttttttg 2556481 gcaaactcag caatctcatt cagctcttcc ttcgaataaa ccgaacctgt cggattcgat 2556541 ggtgagcaga tgagaatggc ctttgttttt tcagtgactg ccgcttcaaa atcagcagcc 2556601 gttgctttaa atcctttgtc tgccgttgta tgaacgtgaa ccgggatacc gcctgccaaa 2556661 gaaacaagcg catcgtacgc aacaaaacac ggctcaggaa tgatgacttc ctcacctgga 2556721 ttcacaatgg cgcggatcgc aatatccaaa gcctgacttg cccccactgt cacaatcagc 2556781 tcattatctg gcgagtagct aaggtcaaac ctgttgctca aataacggct gatttcctcc 2556841 cgcaatgagt ataaacccgc attggccgtg tatgacgtat atccttgttc aagagagaga 2556901 atgcttgctt cgcggacatt ccatgcggta acaaaatcag gctcgccgac gcctaaagaa 2556961 atgacgcctt ccatcgttgc cgccaaatca aagaatttgc ggatgccgga tggttttatt 2557021 tgttgtacat agtctgataa atacgaagtc atttacggtg acaccacgat tcttttgtcg 2557081 tcgtctcctg tttcaaacac tttgccgtca tgcttgtatt ttttcaggat aaaatgggtt 2557141 gtcgtagata caactgaatc aagcgttgag agtttatccg aaacaaaacg cgctacgtca 2557201 gacatcgaat tgccgcgaat cacgacagac aaatcgtata cgcctgacat caggtaaact 2557261 gattcaacct cttggaatcg gtaaatccgt tccgccactt catcaaaacc gacgccccgc 2557321 ttcggcgtta ctttgacgtc aatcatggcc gtaacgccct catgtccgtc gacttttcgc 2557381 cagtcaatca tagcggaata atcgataata accttttctt tctccagttt gtcaataatt 2557441 gttttcactt catttacagg gatgcccgcc atctttgcga ttgtttctaa atcggcgcgg 2557501 ctgttttcgt ctaaaatttc taatatttct gtttcttttt ctgtcaattt catttgattc 2557561 acacctttgc aatgtcaaga aatctcatga cattatatca cgttttttga cgaatgctaa 2557621 gaaaaaacga ggagaaactt ccgctagaat tgacaatttc agggcataat acaaccatca 2557681 aaaaaaggga gtgacacaga atggaggcgg tttcaccaat aaggcggttt acggtcgatg 2557741 gagtcaatgt atactacgaa cattatcaaa atcccggcag gcaaacgctg gtctgcgtac 2557801 acggtttttt atcatctgca ttcagcttca gaaaagtaat tcctctcctt cgggacaagt 2557861 acgacatcat cgcgcttgat ttgcctcctt tcggccaatc tgaaaaatca agaacgttta 2557921 tctataccta tcaaaacctt gctaagcttg tcattgggat tttggagcac ttgcaagtga 2557981 aacaggctgt gcttgtcggg cattctatgg gcgggcagat atcgctgtct gctgctctcc 2558041 aaaaacctga gcttttttca aaggttgtgc tgctttgcag ttcagggtat ttaaaacgtt 2558101 cacacccgac gattattttc gggacccata tcccgtattt tcatctttac atcaaacgct 2558161 ggctctcgaa agaaggcgtg atgaaaaatt tattaaatgt ggtgcatgac aaatcgctga 2558221 ttgatgagga gatgattgac ggctatggca gaccgtttca ggacgagcag attttcaaag 2558281 ccatgacaag gtttatccgc cacagagaag gagatttaga acccgagcaa ttgaagaaaa 2558341 tgaacaagcc tgctctattg atttggggcg aggaggatcg aattgtccca atggagatcg 2558401 gtaaacggct gcacgcagat ttgcctaatt ccgtgctgta ctcacttggc cagaccggac 2558461 atctggtgcc tgaagaacgg cctgaactta tttctgaaca cattgctgat tttatcaaat 2558521 aacaaaaaaa ccggtgctga accggttttt ttaaggcgtg caggagctgc tgtttttaat 2558581 gaataaaagc tggccagcca cttcccggca gctggcgatc ggcagcgttt gttcaaaaga 2558641 agtttcaaat atttgctgaa tgcttttcgc cagcaagtcg ggatcgtttt catcatagac 2558701 tgcctgcacg acatcaacag cctccgtttc gtaaaactct tctccatatt taaacgggtc 2558761 ccatttggca atgatcttaa tcatttccct gaccgcatga ctttcttcca tattcatcac 2558821 cgcttataat aaaatttgca gttctatctt atcatagtga agcttagaag aataaacata 2558881 catgaggggg taacagaatg aactttgata aacgagaaga acgccttggc acccaatcgg 2558941 tcaaatggga taaaacaggc gaattatttg gcgtgacaga cgccctcccg atgtgggtgg 2559001 cagatatgga ttttcgcgcc ccggaagcga taactgaagc gttaaaagag cgtcttgacc 2559061 acggtatttt tggttataca actccagatc aaaaaacgaa ggatgctgtg tgcggatgga 2559121 tgcaaaacag gcacggctgg aaggtaaatc cggaaagcat cacattcagc cccggcgttg 2559181 taacagcttt gagcatggcg gtacaagctt ttacggagcc gggcgatcaa gtagttgttc 2559241 agcctccagt ttatacgcct ttttaccata tggtggagaa aaacggccgg cacattttac 2559301 ataatccgct gctagaaaaa gacggcgcat atgcaatcga ttttgaagat ttggagacaa 2559361 agcttagtga cccaagcgtt acattgttta ttttatgcaa tcctcataac ccttctgggc 2559421 gttcatggag ccgggaagat ttactgaagc taggcgaatt gtgccttgag catggcgtca 2559481 cagttgtatc ggatgaaatc cattccgatt taatgctgta cggacataaa cacacgccgt 2559541 tcgcttcgct ctctgacgat ttcgctgata tttccgtgac atgtgctgct ccaagcaaaa 2559601 catttaatat cgccggattg caggcttcag cgatcattat tccggatcgc ctgaagcgcg 2559661 ccaagttttc cgcaagcctt cagcgaaatg gtttaggcgg actgaacgcg tttgccgtca 2559721 ctgcaatcga agccgcgtat tcaaaaggcg gaccgtggct tgatgaattg atcacttaca 2559781 ttgagaaaaa catgaacgaa gcggaagcct ttttgagcac cgagctgcca aaggtcaaaa 2559841 tgatgaagcc ggatgcatca tacttgattt ggctcgactt cagcgcttac ggcttgtccg 2559901 atgcagagct tcagcaaaga atgctaaaaa aaggaaaagt tattttagag cccgggacga 2559961 aatacgggcc tggcggagaa ggatttatgc gcctgaacgc cggatgctct cttgcaaccc 2560021 tgcaggacgg cctgcgccgc atcaaagccg cattatcgta aatatagctg taaacgcctt 2560081 tacgtcttca tttgtaaagg cgttcttaat aaaggaattt tatattttac ttctaatatt 2560141 tagtgttata atagattcat attttatacg aaaggatttc acacgaatgg aaattctaaa 2560201 agactatctt ctgcacatct gctttatttt gtttcctatt cttctttacc aagtgttttg 2560261 gcttggaaaa cctgcgattc ttgtgccaaa aataaacagc ggtttggtca cgctcttcgc 2560321 ctgcggcgcc tccgttttat gcattatttt cccgattcat gaaatggact acatacaata 2560381 cggccttcag atgattcccg ttatcatttg tttattttac attagtaccg cttccggact 2560441 tacagtcgcc gcatctgtcc tatgttttga actgcttttt tacgaacctt ccgcaatgtt 2560501 tgttttcact ttgctgcctt ttcttatcat tatcccaatc ttatttcaga aaaaatggcc 2560561 attcatgtcc aaagcgaaaa aactgctgct gtctttattg atcagctgcg tggagatttt 2560621 cctatttttc gcctcaagct ggattctttc cgccttgaat attttaaatt ttcaaaaatc 2560681 aggaattttc gtttacgagg cggcagtctc agggcttttc cgctccagtg ttcttctatt 2560741 aagcatctat attatcgaaa gcatcgccga aaatatcgcc ctgcgttcac agcttatcca 2560801 ttctgaaaaa atgacgattg tgagtgaact ggcagcgagc gtcgcccatg aggtcaggaa 2560861 tccgctgaca gttgtccgcg ggtttgtcca gctgcttttt aatgacgaaa ccctacaaaa 2560921 caagtcgagt gcggattaca aaaagcttgt actgtcagag cttgaccggg cgcaaggcat 2560981 tatcacaaac tatctcgata tggccaaaca gcaattatac gaaaaagagg tttttgacct 2561041 atctgccctt atcaaagaga caagctccct tatggtgtcg tacgccaatt acaagtcagt 2561101 aaccgtcgag gctgaaacag aaccggacct tttgatatac ggagacgcaa caaagctgaa 2561161 gcaggctgtc atcaacctga tgaaaaacag tattgaagcg gttcctcacg ggaaggggat 2561221 gatccacata tcagccaaaa gaaacggcca tacgatcatg attaacatca cagacaatgg 2561281 ggtcgggatg acagaccatc aaatgcaaaa actcggcgaa ccttattatt ccttaaaaac 2561341 gaacggaacg ggactcggcc tcaccgtaac cttttccatt attgaacatc atcacgggac 2561401 catttcattt aacagcagct tccaaaaagg cactacggtg accattaagc ttcccgctga 2561461 tcttcctcac tagcaaatcg attggaactt taatagaata aatgcgaggt gatgacagat 2561521 gagcacgttt gagacaggct ctatcgttaa aggattttac aaaacaggtg tatacatagg 2561581 agaaatcacg gcttgcaggc cgcagcatta tttagtgaaa gtgaaagcgg ttcttaccca 2561641 tcccgctcag ggagaccttc atcatccaaa acaggcggat gtgccatttt ttcatgagag 2561701 aaaagcgctc gcatatggtg aacagaccaa tatcccccac catatggtga agccttatga 2561761 cggtgaagtg ccggattata ccgaatctct gcgggaggcg acagcacaga tgagagccaa 2561821 attgaatgag gatggttcgg agtgggcaaa gcgctccctt cataatctgg acattttaga 2561881 aaaagaatat tttaaccggc cataacccag tctgacaaaa gattgggttt tttacgtcgc 2561941 gcgcttcaac agttcggtta aatcgattct ctcgccgatt gtgggcggtt ttggcttttc 2562001 gagatactgc ttatcctgct caacaagctt aaaaagttta tatgctgtga gagcatcatc 2562061 aagcgcttta tgatgggtgc cggttccgga atctccatac tcttcggcag ctttccataa 2562121 acccgtcaat gtccggtctc caaaaaagtt tttgtattca agcgataaat ctctcatttc 2562181 tcccttaaac gggaaaggga tatggttaaa catacagttt tgcttcagca ctttcatatc 2562241 catgtttccc cacgtaataa ttgtgctgtt tttctcagga tccagctcgt ttagtttacg 2562301 gatgaaatcc tcgaatctca ttccttcgtc tacctgtttt tgggttattt ttaaaaatga 2562361 tttgcagcgt ttcgtaagct tcgggaactt tttcggtcta acatagctag aaaacgtctc 2562421 aaccacttca tcatcaatcg actttacaat tccggcttca atgatttccg ggaagaagtt 2562481 ttgaggactg tactttccat caggcattgt aaattcgaaa tcaataatga gtaagctgtt 2562541 tgtcgtcacc ttttacacct gcctttcctc cgatcagaaa atgctatctt tatagtatat 2562601 caattcccct tctcgacatt tcttcatttt ctaaaaataa tgaattttcc cagccgcttc 2562661 gtttctttta aattgtgaat cgtttcttta taattagtaa ggaacccgaa ataataagaa 2562721 ggtgatgtta tttctatccg taagaaaaac tttgtcattg tgtggctggc gaactttttt 2562781 gtctccgcta gcacaacgat gatcgttcct tttctctcct tatacattga gacgctcagc 2562841 tctttttcaa acggctttgt gcaaaggtgg agcggctatg tgttcggcat tacatttctc 2562901 atggcgtttt tggtatcccc gttttgggga cggttcggag acaaacgcgg atacaagaaa 2562961 atccttatgg caaccggaac aggcattgcc ctcagcattt tcttcatggg ctttgttaca 2563021 tcggtgtacc aattgttttt tctgcgtatg gcaatgggtc ttgtaaccgg attcatcccg 2563081 acatctcttg cgatgatttc ggcacagact ccgaagagct cagctggcaa aacactcggc 2563141 acgctgcaaa tggggcaagt gtccggaagc ttgttcggcc cgcttttggg aggcatgctt 2563201 gctgatcgtt tcggctttac gtataccttt tttatcacat cctttgtgat tttctcgtct 2563261 gttcttctcg tgttatttgg tgtcaaagaa aagcatcttg cagagaaaac agccaaacgt 2563321 acgtcttact cgagaaaaga agtgctctcc tatatttttc accatccggc gctgtgggtc 2563381 atgatgctgt taaccatgct gattcaaaca ggcaatttca gtatccagcc cctgctcgct 2563441 ttatatgtaa atgagctgca cggacctgtc aatcttgcct ttttctccgg catggcattt 2563501 tcagcaacgg ggctcggaag tttgctgctg gctagaaaat ggggtgatct gggcgaccgc 2563561 tacggccacc gccgcatttt aatcggactt ttgctcgccg cctctttctt ttttattccg 2563621 caggcgctcg cgtcctcact cagcgtgctc cttgttttca gatttttatt cggaatggcg 2563681 atgggcggtt tgctgccatg cattacggca gcgatccgcg ttcaggctcc cggcagcatt 2563741 caaggtgaag ttctcggcta caatgtcagc tttcgctttt taggaaacgt gctcgggcct 2563801 ctgctcggcg gaatcatatc gagccatttt accatttcgg ccacctttta cgtcacggcg 2563861 tttctctttt tcgccggcgc ctgcatgctt tggatcatgc agaaacttcg gaaagattct 2563921 tatgccaaag caagctgatt ccgagaaaaa actaaggaat cttctaaatt taaccttctc 2563981 gtaatctcaa aagaatggta cgatatggct agaatttagg agaaaagaga gtgaccatgt 2564041 tacgaaaaat aatcggatgg attttgctcc tttgcataat cccattgttt gcatttacag 2564101 ttatcgcttc cggaaaagaa gtaaaacaaa tgaagtccct ggatcaggtg cttgataaaa 2564161 atattgatct gaaagatatc agccttgttc agaacagcta catgtatgac agggacggct 2564221 cccttgtctc ggaaatcgtc agcgaccacg aaaaccgtgt gctcgttcca tttaacaaga 2564281 ttcccgagga agtcaaacag attttcttaa catctgagga ccgccatttt tacgagcata 2564341 aaggctttga ctttatggga atggtgcggg ctactgcttc taacgtaaaa gacaagaaaa 2564401 ttgaccaggg tgccagcacc atcacacagc agctttcaag aaacttgtat ttgagccacg 2564461 aacgctcctt cagccgcaag ctgacagagc tcgcgtattc ctatcagctg gagaaaaaat 2564521 atacgaaaaa tgaaattctt gaagcttact taaataccat ttatttcaac aacggtgttt 2564581 acggcgtcgg ttcagcagct caattctatt tcagcaaacc gctgaaatct ctcacagtgg 2564641 gagaaatggc ttttatctgt gctataccta ataaccctac attatatgat cctctcaagc 2564701 attttgacta cacgaaaagc cgtcaagaac gtttacttaa agggctaaaa gatgccgggg 2564761 tcattacgga caaagagctg aaaaaagccg taaaacaaaa aatcaaactg gatgttgaaa 2564821 aaagagaaga caaatatcct gactacgttt cctacgtcaa tgatgaattc actcagctgg 2564881 tgtctgaatc agaaggcttt gataaacgcc ttcaaaaagc atcaggaaaa caaaaagaaa 2564941 agatcgagaa cgagctgtcc gcaagagtca gcacgctgat gaaagacgga gtgaaaattt 2565001 atactgcact tgatccgtac atgcaaaatc aagttgtggc acaaatgaat tccaagctcc 2565061 cgtatgcgga cgtacagggc ggagcggctg tgattaatca ccagacgcat caaatcattg 2565121 ctctatccgg cgggaaaaac tatcaaaaat atgactttaa ccgcgcctac caggcgtaca 2565181 ggcagccggg ttcatccatt aagccgcttc ttgattacgg cccttatatt gaacagaccg 2565241 gcgcgacaac aagcagcacc attgatgcca gcaagttttg cagcaaagac tactgtccgc 2565301 aaaactacaa taaccgcact tacggcacag tgacgcttga tacggcgttt aaaaattcat 2565361 ataatacccc ggctattaga atgctcgacc gcgtcggcat ccaaaaggca ttcagttata 2565421 ttgagccgta tcattttgcc aaacttgtcg acagtgacta tcttcttccg gcggcgcttg 2565481 gcggatttac aaacggcatg acgcctcttg agatgacaaa ggcttatacg acattcggaa 2565541 acagcggaag ctatacgccg agccatgcga ttacaaaggt gacagacctt aaaggaaaaa 2565601 cactttataa atggaatgat aaagcgactc aaatattcag cgtccgcacg aacatgcagc 2565661 tgaaaaaact gatgtcttcc gttgtgaaaa gcggaacagg gaaaaaagca tatttcaatg 2565721 cgccttacat cggcggtaaa accggaacat caaatgatta tcacgatatg tggtttgtcg 2565781 gcctgactga tacgtataca atgggtgtct gggtcggaaa ggatacaccg accagcgttg 2565841 aatatcttca cagcatcagc cctcagcttt ccatctggaa aggaacgctg caagcggctt 2565901 attaaaggat cggaggggat atggagtgac ttcagaacaa attccaaatc gcgttttgct 2565961 gtttgacggt gtctgcaatt tatgcaatgg cgccgtgcag tttatcatta aacgtgatcc 2566021 ggacggattg atttctttca catcgctgca gtcggaaaca ggacagagcc tgctgaaaaa 2566081 aagcgggctt ccgactgatc ggtttgacag ctttgtcttt attgaagacg gccaagtgta 2566141 cacaaagtca actgcagcca ttaaggtttt caggcatctg cgaggcccat ggcggctctt 2566201 cgtccttttt ttcgcagtgc cgaagcctgt cagagatatg gtctattctt tcattgccaa 2566261 aaaccgctat aagtggtttg gcaaaaaaaa tgaatgtatg ctcccctccc cttccattaa 2566321 aaaaagattt ttaccgtaaa taaaaaatgg ctaggaagct agccatcaca gattgttgac 2566381 aaaatcctaa aacggcttcg ttttaggatt ttgtcatcta ttcagcgtga ttgaaaactt 2566441 ttgaagttgt gaaacggcgg aaacctgaga atctagccgc cgtttcattg cgtacagagc 2566501 acgaagcgca aatctgacca ccaaacgctg aaatggctag cttacacagg taagctagcc 2566561 attatgctat tataaagctt gataaatatg aacagaatac cgataacaaa ggtaaaccaa 2566621 aacagcagtt ccaatagaat gaatccaact aatgacatga gagaaagcgt cgaataaatc 2566681 cggtatacgg taaacacaaa gtaagcgagc gtgacgaccg caaaccagat cacaatccaa 2566741 atgacatttt gcaagagcac aaaggataaa atcccgccgc ccaaataaat catggaaccc 2566801 attctgagtt ttttcaggtt gttcccttcc ggatcattag caaaaaacag caatgacagc 2566861 tcggtcacgg tatttgcaat taatttcaga gcggacagaa ccataaaata taaaagtgca 2566921 aaggcagcaa ataacgcaag cctgattcct ttctctgaaa aataatcgag cattccatca 2566981 tacattccaa atgaagacag catcttcaac gcataaagtg aagttgagat ggataaggac 2567041 gaactaaaaa gcaggatcgc aatcagcgga aaatatcctg tcaaataagt atttttcata 2567101 taaaaaagtc cctttctata atctacctca tttattatgg aggacttaaa acacattgac 2567161 aagataaatt attccatttt ttctcctttt tacgaattac gggcccaaat cttcacaaag 2567221 cagcattttg agagtaaagt agtacgcagg aatcataaaa cgtaaggaag ttttatatga 2567281 aaaaaacatt aaaactgcaa accagactca ccatatttgt ttgtatcgtt gtattaatcg 2567341 cattgctcat tacgtttttt acagtcggtg cccaaaccac caaacgaatt agagatcagg 2567401 aaaaggccac tgcgctgcag actgctgaaa tggtagctga agcgccgatg acagccgctg 2567461 ctttagaaag cggaaaaaaa caaaaggaac tgcagagcta cacaaagcgg gttcagaaaa 2567521 ttaccggcac ggaatttgtt gtcgtcatgg atatgaacgg tatccgcaaa actcatcctg 2567581 acccgagcaa aatcggaaaa aaattcagag gcggtgatga gtccgaggta ttaaaagggc 2567641 atgtccatat cagcacagcc tctggcacgc tcgggaaatc gcagagagcg ttcgtccctg 2567701 tctacgcgga gaatggaaaa caggtcggtg cagtcgcggt cggcatcacc gtaaatgaaa 2567761 ttgatgaagt gatcagccat agcttacggc cgctttactt tattatttgc gtcagcatct 2567821 tcgtcggtgt gatcggagcc gttatcgtcg cccgtacagt gaaaaatatc atgtacggac 2567881 ttgaacctta tgaaattgcg actctgcttg aagaacggag cgcgatgctg gaatcgacga 2567941 aggaaggaat actcgctgtc gatgaacatg gcaaaattaa acttgccaac gcggaagcaa 2568001 aacgcctatt cgtcaaaatg ggcatcaaca caaatcccat tgatcaggat gtagatgaca 2568061 tcttgccgaa aagccgcttg aaaaaggtca ttgagacaaa aaaacctctt caagacagag 2568121 acgtccgcat taacgggctg gagcttgtgt ttaatgaagt tcctatccag ctgaaaggac 2568181 aaactgtcgg agcgattgca acattccgcg acaagaccga ggtaaaacat ttagctgaac 2568241 agctttccgg tgttaaaatg tatgcaaacg cactgagagc gcagtctcat gaatttatga 2568301 acaaactgca tgtgatatta ggtctcgtcc agctgaaaga gtatgatgat cttggagatt 2568361 atattaaaga tatagccata cagcaaaaat cagaaacaag tgaaattata aatgatgtca 2568421 aaagctccgt actggccggt tttctgcttg gaaagcaaag ctttatacgt gagcagggcg 2568481 caaatcttga tattgaatgc aacggtgtca tcccgaacgc ggcagaccct tctgtcatcc 2568541 atgaacttat tacaatcatc ggaaatctca tcaacaatgg cttagatgcc gttgccgata 2568601 tgccgaaaaa acaaatcacc atgtccatgc gcttccataa cagcatactt gatattgaaa 2568661 ttaccgatac tggagcaggc atgtctgaag aagaccaagc caaagtattt gaacaaggct 2568721 attcaacaaa gggcaaaaac cggggattcg gcctttattt cacacagcaa agcatcgaaa 2568781 atttaaaagg ccaaatgatc ctcacaagcg aaaagaatga aggaacgaca ttcagtattc 2568841 gcatcccgta cgaaccgaag gaggaaaatc atgattaatg tactaatagt tgaagatgac 2568901 cccatggtgg gtgaattaaa taaacgatac ttaagccaaa tagatggctt tcagctgaaa 2568961 ggcatcgctt cttcctttca aagcgctctg catattttag gggagcacca tattgacctc 2569021 attttgcttg atatttatat gccgggaaaa aacgggctgg aactgctgac ggaattgaga 2569081 gcccaaaatg aagcggttga cgtgattgtc atctcagcgg ccagcgagct tgacgtgatc 2569141 aagaaaacac ttcggtacgg agctgttgat tatttaatca aaccgtttga atttgaacga 2569201 ttccaaacgg ctctgtctga ttacagacga aaacaaaagg tgtattcaac ccatcgcaac 2569261 atgagccaaa aagaactgga cgccgagctt tttcaaaaga aagaagcaac agaaaaagtg 2569321 cagcttccta aaggcctgac aaaaagcacg ctgaagctga tctggtccag tatccagtca 2569381 tttgaaaatg aatcttttac gacagaagac ttggcaaagc acacagaaat ctctcaagta 2569441 tccatacgaa aatacttaaa gtttcttgaa gatatacagg ttctgaatgt agaaatggcg 2569501 tacggaacga tcggaagacc tgtgtttcag tacaacgtca acaacagtaa cattaacgga 2569561 ataaagcaat atctataaga aaacgcactg cttgctttga gcagtgcgtt tttctgtcat 2569621 atctcttgcc aagatgcttg attctattgt tgataagtta tacaagaata acaaagggct 2569681 ttcacatttt taagcaaata attctaaaaa tagataattt ttaaaaaatt atgcgaaatt 2569741 ctatttattt cttattagtt aaatgataaa ttatgattgg ttagttgatc ccgaaaaact 2569801 aagtcataag tcttacttca gaaaacgatg tcacggtttt ccgcccggaa cgccttccgc 2569861 atccttctct tccccgcctt tcgaaggaaa tactcacacc acgcttattc agggaagaat 2569921 agaactgtct cagcgcattc catttgttat tatcagaaaa ttttatcgat tctaagaaat 2569981 tgttcaggac agcccatcac atgactggcc ggatcagctt tgaaccaaat ttttctgggg 2570041 ggttatatct tgaataaacg aaaaatcgga ttggcgatgt cacttgtgat cgcagcaggc 2570101 accatattag gagcatgcgg aaacagcgaa aaaagcagcg gctcaggcga aggcaaaaac 2570161 aaattcagtg tggcgatggt tactgacgta ggcggagtgg atgacaaatc cttcaaccaa 2570221 tcagcctggg aaggcatcca agcctttggg aaagagaatg ggctgaaaaa aggcaaaaac 2570281 ggttacgact atcttcaatc caaatctgat gcagactata caacgaactt aaataaattg 2570341 gcgcgtgaga attttgactt aatttacggc gtcggctact taatggagga ttcaatcagc 2570401 gaaattgctg accagcgtaa aaatacaaac tttgcgatta tagatgctgt tgtcgataaa 2570461 gacaacgtcg caagtattac gtttaaagag caggaaggct catttctcgt cggagtggcc 2570521 gcagccctat caagcaaatc aggaaaaatc ggctttgtag gcggcatgga atcagagttg 2570581 atcaaaaaat tcgaggtcgg cttccgtgcc ggcgtgcaag cagttaaccc taaagccgtt 2570641 gtagaagtga aatacgcagg gggtttcgat aaagccgatg tcggtaaagc aaccgccgaa 2570701 agcatgtata aatcaggcgt agatgttatt tatcactctg cgggcgccac tggcacaggc 2570761 gtctttactg aagcgaaaaa cctgaaaaaa gaagatccaa aacgcgatgt ctgggtcatc 2570821 ggtgtcgata aagaccaata cgcagaaggc caggtagaag gaacagatga taacgtcacc 2570881 ctcacttcca tggtgaaaaa agtagataca gtcgttgaag atgtaacgaa aaaagcgagt 2570941 gacggaaagt tcccgggcgg cgaaacactt acctacgggc ttgatcaaga cggagtcggc 2571001 atttctccat ctaaacaaaa tctatcggat gatgtgatca aagcggtcga taaatggaag 2571061 aaaaaaatca tcgacggatt ggaaatcccg gcaactgaga aagagctgaa aaccttcaaa 2571121 gctgaataag aatcgcaggg ataaggaggt cgagccctta tcccttgttt ttcttttatt 2571181 ttgaaataaa ggagcggtca atcaatggaa tatgtcattg aaatgctcaa tatccgcaag 2571241 gcgtttccag gtatcgtcgc caatgacaat atcaatcttc aagtcaaaaa aggcgaaata 2571301 cacgcgttgc tcggtgaaaa cggagcgggg aaatcaacat tgatgaatgt ccttttcggg 2571361 ctgtatcagc cggagcgggg tgaaattcgg gtgcgcggcg agaaggtgca catcaacagc 2571421 ccgaacaaag cgaatgacct tggaattgga atggtgcacc agcactttat gcttgttgac 2571481 acctttacag ttgctgaaaa tattattctc gggaaggagc caaagaagtt tggcagaatt 2571541 gaccggaagc gtgctggcca agaggtgcag gacatttccg atcgatacgg cctgcagatc 2571601 catcctgaag caaaagcagc tgacatatca gtcggtatgc agcagcgcgc agaaatatta 2571661 aaaaccctct accgcggtgc cgacattctg atttttgatg aaccgacggc tgttttgacg 2571721 cctcatgaaa ttaaggaact gatgcaaatt atgaagaacc tggtcaaaga agggaagtcc 2571781 atcatcttaa tcacccataa gctgaaagag attatggaga tttgtgaccg cgttacggtt 2571841 atccgtaaag gaaaaggcat caaaaccctt gatgtccgtg atacaaacca agacgaactc 2571901 gccagtctaa tggtcggccg tgaggtatcg ttcaaaactg aaaagagagc tgctcagccg 2571961 ggagcggaag tgcttgcgat tgacggcata actgtaaagg atacccgcgg aatagagaca 2572021 gtcagagatt tgtctctttc tgtcaaagcg ggagaaatag tcggcatagc aggcgtcgac 2572081 ggaaacgggc aatctgagct gatcgaagcg gtgacaggac tccgcaaaac agattcagga 2572141 acaatcacct taaacggaaa acagatccaa aacctgacgc caagaaaaat cactgaatcc 2572201 gggatcgggc atattcctca ggatcgccat aaacacggtc tcgtccttga ttttccaatc 2572261 ggagagaata tcctgctgca aagctattac aaaaagccgt attcagcatt gggcgtttta 2572321 cataaaggcg aaatgtacaa aaaagcacgc agcctgatca ctgagtacga tgtcagaacg 2572381 ccggatgaat atacacacgc tcgggcattg tcaggcggaa accagcaaaa agcgattatc 2572441 gggcgggaaa tagaccgaaa tcctgattta ttaattgccg cccagccgac tcgcggcctt 2572501 gatgtcggag cgattgaatt tgtccataaa aagctcattg agcagcgtga tgccgggaaa 2572561 gccgttcttc tcctctcgtt tgagcttgaa gaaattatga atctcagtga cagaatcgcc 2572621 gttatttttg aaggacgcat tatcgccagc gttaatccgc aggaaaccac tgaacaggag 2572681 cttggtctct tgatggcagg aagcacgcaa aaggaagcgg ggaaagcaaa tggttaaacg 2572741 actctctcat ttactcgtgc cgctcatcgc aatcatactt ggtcttgcgg ccggcgcgtt 2572801 gattatgctt gtgagcggct acagtgtggc tagcggatat tcggctttgt ggaatgggat 2572861 attcggagaa atctattatg tcggagaaac aatccggcaa attacgcctt atattttatc 2572921 cggattggct gtcgcctttg cattccgaac cggactcttt aatatcggcg tcgagggaca 2572981 gctgctcgtc ggctggacag cagcggtttg ggtcggtacg gcgtttgacg gaccggcata 2573041 tattcacttg ccgctcgcat tgattacagc ggcagctgca ggaggattat gggggtttat 2573101 tcccggcatt ttgaaagcgc gattttacgt tcatgaagtc attgtcacca ttatgatgaa 2573161 ttatatcgcg ctgcacatga ccaattacat catttcaaac gtcttgacag atcatcagga 2573221 caagacgggg aaaattcacg aatccgcctc cctccgctct ccttttcttg aacagatcac 2573281 cgattactca cggctgcatt tgggaatcat cgttgccctt ctcgcagcag ttatcatgtg 2573341 gtttatcatc aacaaatcta caaaaggatt tgagctccgg gcggtcgggt ttaaccagca 2573401 cgcttcccag tatgccggca tgagcgtgcg gaagaatatc atgacctcca tgcttatctc 2573461 cggcgctttt gcaggtcttg ccggagccat ggagggccta gggacattcg aatacgcagc 2573521 agtgaaaggc gcatttaccg gcgtaggctt tgacggtatc gctgtcgctc ttctcggggg 2573581 aaacacagcc gtaggcgttg tactggcagc atgcctgctt ggcgggctga aaatcggcgc 2573641 attaaatatg ccgattgaat caggcgttcc atcagaggtc gttgatattg tgattgccat 2573701 tattattcta tttgtggctt caagctatgc gattcgtttc gtcatgggca aattgaagaa 2573761 aaagggggcg aactaagtgg acattgtgca gattttatct atcattgtcc ctgccacact 2573821 cgtctatgcg gccccgctta ttttaactgc tctcggcggc gtgttttccg agagatcagg 2573881 tgtggtgaat atcggcctag aaggcctcat gattatcggg gcgttcacca gcgtgttatt 2573941 taatttattt tttggtcagg aattaggtgc cgccgcacct tggctttcgc tccttgccgc 2574001 catggcagca ggcgccctgt tttcactgat tcacgcggca gcggcgattt cgtttcgcgc 2574061 cgaccagaca gtcagcggtg tcgccattaa catgctggcg cttggggcaa ctttatttat 2574121 cgtcaaactg atctacggca aagcgcagac agacaaaatt ccagagcctt tttataagac 2574181 gaaaatcccc ggtttgggcg atattcccgt cttgggaaag atcttctttt cggatgtcta 2574241 ttatacgtct attcttgcaa tagcacttgc ctttatttcc tggtttatct tgttcaaaac 2574301 gccgttcggc cttcgtatcc gttctgtcgg cgagcatccg atggcggccg atacgatggg 2574361 aatcaacgta tataaaatgc gctacatcgg cgtgatgatc agcggattgt tcggcggtct 2574421 cggcggcggc gtatatgcct ccacaattgc gcttgatttc acgcactcta ccatctccgg 2574481 gcaaggtttt atcgccctgg cagcgcttgt attcggaaaa tggcatccga tcggagcact 2574541 gggggccgcc ctgtttttcg gattcgccca aagcttaagc atcattggat cgctgctccc 2574601 tctttttaaa gacataccaa atgtgtatat gctgatggct ccttatatct taacgattct 2574661 cgctttaacc ggctttatcg ggcgggcaga tgcgccaaaa gccaatggcg tgccttatat 2574721 taaaggaaaa agataaacat tctcccctgg gaagacgatt ctcagggatt tttttctaat 2574781 ccaaaagacc cccttaattt aattgtttat tagtttttta acttaaaaaa atatgaagtg 2574841 ttaacgcttt cttgtagact gtaacaaaca atacatgggg gtgtatgaca tgggagcaat 2574901 tccaaaaacg gggacaattt cacctgagca aaaagactca caggagaaaa acctgtttca 2574961 aaaaatttgg tcttgggaaa tcggtgtgat tcctttgcca ttatacacag tattagctgt 2575021 tattattatt cttgcagcat attacaatga gctgccggca aatatgcttg gcgggtttgc 2575081 catcattatg attcttggtg tgtttctcgg agacataggc caacgcatac cgatattgaa 2575141 ggatattggc ggccctgcta ttttatcttt gtttgttcct tcatttttag tcttttacaa 2575201 tgtactgaat tcaacatctt tagacgctgt aaccaacttg atgaaaacgt ctaacttcct 2575261 ttatttctat atcgcttgcc ttgttgtggg aagtatcctc ggtatgaaca gaattgtttt 2575321 aatacagggg tttatcagaa tgttcgttcc actggttgca ggaacgatcg cggccgttgc 2575381 agccggcatc cttgtcggat ttatttttgg ctatagtgcc tatgattcct ttttctttgt 2575441 tgttgtcccg attattgccg ggggaatagg tgaagggatt ttgccgcttt caatcgccta 2575501 ttcacaaata ctgggctcat ccgccgatgt atttgtgtct cagctggtgc cagccgcaat 2575561 tataggaaac gtttttgcta tcatatgtgc agccttaatg aaaaagcttg gcgacaagcg 2575621 tccagatcta aatgggaacg gacgtctcgt aaaatctaaa aaagcaaatg agattttcaa 2575681 tcaaaaagaa gccgaagcaa aaattgattt taaactaatg ggagcaggag ttctgctcgc 2575741 gtgtacattc tttatttttg gcgggttatt ggagaaattc atcttcatcc cgggcgcgat 2575801 cttaatgatt atttcagctg cggctgtcaa gtatgcaaat attcttccga aaaaaatgga 2575861 agaaggcgct taccagcttt ataagtttat ttcttcaagc tttacatggc cgctgatggt 2575921 cggtctcggc atcctcttta ttccgttgga tgacgtagcg tctgtgattt ctataccgtt 2575981 tgtcatcatc tgtatttcag ttgttatcgc gatgattggt tctggatatt tcgtaggcaa 2576041 gctgatgaac atgtatccgg ttgaatccgc aatcgttacc tgctgccaca gcggtctcgg 2576101 cggaacgggt gatgttgcca ttttatcggc atcaggaaga atgggcctta tgccgtttgc 2576161 ccaaatttca acccgtctcg gcggtgcagg cacagttatt tgcgcgacag tgctgcttcg 2576221 ttttttcact tcataaacag aaagagttcc gttttatgcg gaactctttt tttatttatt 2576281 cacaatccga atatactctc ggggaccaaa cggcagatcc tttgattccg tctcactcat 2576341 tctggctgac aggtggtgct ccagtaaata cagctcccac tcatcacaag ccgccacacc 2576401 gctgcgcccg tcatattgat tcaacatgaa tgcccctgca aatactgagc agaataaacc 2576461 tgagcacatc acgacttttg ttttcacatg accagctcct ttccttcagc ttgatcagga 2576521 ttgattttaa atatacaaat aacctctttt ttgttagact tattttgagg tcaaaagaac 2576581 tcataaaaat ccattacagc agttcgaagc gtggcagctt gcagaaaagt gcgatataat 2576641 ttggactagg tcgtttgacc gtatatttta tacatagcgc atttttcaat tgagaacgag 2576701 aaaaggaggt cttatctttg cagctcttac atcttgctat tttatcgcct tttttatttg 2576761 cttttatcat tcccttcttg gcaaaatacg caaaaagagt gcatacgggc tggtttgtgt 2576821 tgatcctgcc cgtcttgctg tttatatact ttctcccaat gatcaggatg acgcaatctg 2576881 gagaaacact tcgatcggta ttagagtgga ttccgtcact cggcattaac tttaccgttt 2576941 atatagacgg cctcgggtta ttattcgctt tactgatcac aggcattggc tctttggtca 2577001 ctctttacag cattttttat ttatcgaaag aaaaagaaca gcttgggccc ttttatgtct 2577061 acttattgat gttcatgggc gccatgctcg gcgtcgttct agtagacaat gtcatggttc 2577121 tctacatgtt ctgggagctt acaagccttt catccttttt gctgatcggc tattggtata 2577181 agcgggaaaa gtcgcgctat ggcgcagcca aatcactttt gattacggtc agcggcgggc 2577241 tgtgcatgct cggcggattt attctccttt atttgataac ggattccttc agtattcgag 2577301 agatggttca ccaggttcaa ttaattgccg gccacgaatt gtttatcccg gctatgattc 2577361 tcattttatt aggggctttt acgaaatcgg cgcaatttcc tttttacatc tggctccctg 2577421 acgcgatgga agctccgacg cctgtcagcg cttatctcca ttcagctact atggtaaaag 2577481 ccggcattta tgtgattgcg agattcagtc ctattttcgc cttttcagct cagtggtttt 2577541 ggatcgtgtc cctcgtcggc ctctttacga tggtttgggg ttcattccat gccgtgaaac 2577601 aaactgattt aaaatcgatt ttggcgtttt caaccgtcag ccagctcggc atgatcatct 2577661 ccatgctcgg agtcagtgct gcggcccttc attacggaca tacagaatat tatacagttg 2577721 ccgctatggc tgccattttc catttgatca accacgcaac ctttaaagga agcttgttta 2577781 tggcagtcgg gattatcgat cacgaaacag gcacacggga tatccggaag ctaggcggcc 2577841 tgatggcgat tatgccgatt acttttacca tttccttaat cgggacattt tcaatggccg 2577901 gcctaccgcc gtttaacgga tttttgagta aagaaatgtt tttcacaagc atgcttcgcg 2577961 tgacacattt tgacctgttc aacgtgcaga catggggcgt tctgttccct cttttcgcct 2578021 ggatcggaag tgtatttacg tttatctaca gcatgaaatt gctgtttaaa acattcagag 2578081 gaaattacca gcctgaacag cttgaaaaac aggctcacga agcgcctgtc ggtatgctcg 2578141 ttccaccggt cattcttgtc gctttggctg tcagtctctt ctttttcccg aatatattgt 2578201 cgtacagcct gatagagcct gcgatgaact caatctatcc gacactgctt gacggccatg 2578261 agaaattcca cgttcacatt tcacagtggc atggggttac aacggaattg ctcatgactg 2578321 cgggtattgt tgtgatcgga acaattggtt atttgtcgct gaataagtgg aaaggaatct 2578381 ataaactgtt tccttcgaaa ctcacactca accggttata cgataagctt ttgactatga 2578441 tggagaaagg ctcttaccgg gtcacaaaac aatatatgac cgggttttta agagattatt 2578501 tgctgtatat cttcgctggt ttcatcattc tgataggcgg agcttttgcc attaaaggcg 2578561 gattttcatt taaaacggaa ggcatggcta aaatcggtgt atacgaaatc attttgacgc 2578621 ttgtcatgat cagcgccaca gtggcgactg tttttgctag gtcaagactg acggcgatca 2578681 ttgcactcgg tgttgtcggt tatacgcttg cattgttttt tgtcattttc agagcgccgg 2578741 acttggcatt gactcagctc gtcattgaaa cgatttctgt ggcactgttt ctgctttgct 2578801 tctaccattt gccgaaactg aggctgaaaa caaaaacgag aacgttccgg atgacgaatt 2578861 ttatcatttc tttaggcgtc ggtgttatcg ttacactgct cggcatcgca tcctcaagcc 2578921 agcggacaaa agacagcatt gcgtccttct ttgtcaaaca cagccacgat ctcggcggag 2578981 gggataatgt cgtcaatgtc attctcgttg atttcagggg atttgataca atgtttgaaa 2579041 ttacggtatt aacgatagcc gctctcggca tttacagcat gattaaaaca aaagtaaaag 2579101 aggaggggaa aagcggtgaa tgaacaaaaa acaaatgact tgattcttca aaccgcgaca 2579161 aagcttgtat cctttatcat tttgcttttc tctttctatt tatttttatc agggcataac 2579221 gcgcccggag gaggctttgt cggcggactg atcacgtcct cttccatcgt tctcttgctc 2579281 ttggcatatg atttaaaaac cgtgcgttcc cttttgcctg tcaatttcat ttatgtcgcg 2579341 ggagccggcc ttctgctcgc tgtattaaca ggcgttggct cctttgtctt cggggctcct 2579401 tttttaaccc acacattcgg atactttcag ctgccgatcc ttgggaaaac ggagctcgcc 2579461 acagcgacga tatttgattt aggcgtttat cttgttgtcg taggcataac gatgaccatt 2579521 attcaaacga ttggagagga agaataatgg aaatcttaat ggctgtatta gccggtatta 2579581 tttttatggc tgctacgtat ttgctgctgt ctaaaagcct gcttcgcgtc attatcggaa 2579641 cagcactgtt aagccatggc gttcatttaa tgcttttgac tatgggagga ttaaagaaag 2579701 gcgccgctcc gattttgagc gagcatgcca aatcatttgt cgatccgctt ccgcaagccc 2579761 tgattttgac cgcaattgtc atttcttttg gcgttacgtc attcatcctc gtcatggcct 2579821 ttcgcgctta tcaggaattg aaatcggacg atatggatca aatgagggga aatgatcaac 2579881 atgaataatt ttgttatttt gccaatcctg atcccgcttt tgtcggctat tcttctgatt 2579941 ttcatgacga agaatcttat gctcatgaga atcttcagca cggcggcatc ggccatcggg 2580001 attgtgatta gcggcatact tgtacagact gtcttcacaa aaggcatcca gacactcagc 2580061 ctaggcggat ggaaagcgcc gtacggcatt gtgcttgccg cagaccaatt cgccagcctt 2580121 ctcgttctca caacagcgat catcggttta ttggttgggc tttattcctt ccgttctgtc 2580181 ggtgaaaaac gggagcgctc cttttactac tccggcgttc agttcttgct tgccggcgtc 2580241 agcggagcgt ttttaacagg cgatttattt aatatgtacg tattttttga gcttctgctt 2580301 attgcttcct atatgctgat tgtattaggc ggcacaaaaa ttcagctgcg ggaatccctt 2580361 aaatatattg tgtttaatat tgtatcgtct gccctgtttg tcataggggt cggcttttta 2580421 tacgctgtaa ccggtacgtt aaacatggcg gatcttagcg tgaaaatcag cgaatcagga 2580481 caaaccgggc tgatcactgt gattggtgtc ctgctgcttt tggtatttgg catgaagggc 2580541 ggaatcttcc ccctctactt ttggcttcca ggctcttatt acgcgccacc ggcggcaatc 2580601 tccgcgttgt tcggcgcttt gctgacaaaa gtcgggttat atgcgattac gagggttttc 2580661 acattgattt ttattcacga tacagccttt acccatcagt tgatgatttg gctggcggcg 2580721 ctgactgtga tttttggtgt gatcggttca ctcgcttatt cgaatgtcat gaaaattgtg 2580781 atctataaca ttattaccgc tgtcggcgtg attttgttcg gtgtggcagt acacaccccc 2580841 gcatccattc agggcgcgat ctactatctg attcacgata tgctgattaa gggcgctttg 2580901 ttcatgctgg caggtacgct gatcgcattg actggaaccg cgagcctgca taaaatgggc 2580961 gggctgatca aacgctatcc tgttcttgga tggatgtttt tcatttccgc tatttctctt 2581021 gcaggcattc cgccactgag cggatttgtc ggcaaattta aaattgcaga gggcggcttc 2581081 gcagaaggtg aatttacgat atccatgctg attctgcttt cgagtctgct tgtactgtac 2581141 tctgtgctga ggatctttat acatgcgttt tggggcgaag aaaaagaaac gccaaaacca 2581201 aatcatcgaa cagctaaagg acttctttat ccggcagcta tttttctctt gctgtccctt 2581261 ctcttcggat tgggtacaga atgggtgtcg ccttacgttg atcaagcggc cgagacgctg 2581321 ctgaatccgg aaaaatatat cgaagctgtt ctgaaggagt agatcgcatg gcatttcaaa 2581381 ttttattaaa tgtgtttctc gctttttgct ggatgttctt aagcaacagt ccaagcgccg 2581441 caggattcat tacaggctat attctgggaa tgctctctct ctttttcttc cggcgctttt 2581501 tcactcgcca gttttatcta tggaaattga tttctattat caagctctgt ttcattttta 2581561 taaaggaact gtaccttgcc aatgtcagtg tgatgaaatc agtcttatct ccaaaactga 2581621 atatcagacc gggtattttt gcttttaaaa ctgaactgac gaaggactgg gaaatcacca 2581681 tgctttctct gctcattaca ttaacgccgg gaaccttggt gatggatatt tcagatgaca 2581741 gaacaatact ttatattcat gcaatggata tcgaggatgc ggaaaaagcg atttttgaca 2581801 ttcgggagtc atttgaaaaa gccatacagg aggtgagccg gtgatgttta cgctgatcct 2581861 gcaaatcgcg ctcggcatta tggcagtgtc tacctttttg tatgtcattc gtgtcattaa 2581921 aggtccgact gtgcctgacc gggtcgtggc tctggatgca atcggcatca atctgatcgc 2581981 aatcacggcg cttgtctcca ttttgctgaa aacaagtgcg tttttggata ttattttgtt 2582041 gctggggatt ttatcgttta tcggaacgat cgcattttcc aagttcctgg agaaaggaga 2582101 gattatcgaa aatgatcgaa accgctaagg tcgttgtggc tgtattcatt ttgctgggtg 2582161 ctcttatatg cctcattgct tcatttggcg tacttcgcct tcccgatgtg tttacacgcg 2582221 ctcatgctgc ttctaaaggc tcaacattag gtgtcaatat gattctgctc ggtgtcttct 2582281 tctatttgtg gtttgtgacg ggggagctct ccgctaaaat cctgcttggg attctcttta 2582341 tctttattac gtcgcctatc ggcgggcact tgatctgccg tgctgcgtat aactccggcg 2582401 tcaagcttga tgagagaagt gtgcaagatg actataacgg aatcagaaac tttgtgatta 2582461 aacgaaaaga ggattcttat ttataaaaat aagcagccgg acaggcagag ttccggctgt 2582521 ttttttattt cttgatgaca gccagcgtgc atctggatat acagatcagc ctctcttgct 2582581 cgtcatatat gtgaatatga tagacaatcg tcgttctgcc tatatgaacg ggctcggcta 2582641 tcgcctttac cgttccttcc tttacagatt ttaaatggtt ggcgttaatc tccaaaccaa 2582701 cacaagcttg cgttgtatga tcaatcaggt tctgtgcacc tgcgctcgcc gcggtttccg 2582761 ccagggccac tgaagcgcct ccatgcaaat atccgaacgg ctgtaccgtc cgatgatcca 2582821 ccggcatgac cgcaacgcat cgttccgctg tgttttcaac aatctcaata ccaagcgctt 2582881 caagcaatgt gtgcttcata tccatctcta caccccccaa catttaaagt acaccgtctg 2582941 atttcgcaat caaaaccgct tccgtccgtg aaccgacatt cagcttattg aaaatcgatg 2583001 tcaagctgta ttcaatggac cgcttgctta aatgaagggc atctgcgatt tcttggtttg 2583061 taaatccctt ttcaacttct tgaagaatca ggcattctct aggtgtgagc acatcttgtt 2583121 ctttttgaga ggaaggagcc ggctttgttt tttgctgagt catcagctgt ttaaagtaag 2583181 caaaatcgac taaaatttct ccgttgagta cgtggtatat gtattgggtg atcttttctt 2583241 tagattccgt tttgctgatg gcaccgtgca gacccgcacg aatcgcttcc tcgaaataat 2583301 cctcgacctc ataaccggta tacacgataa ttttacaatg aggattctct tgtaaaatct 2583361 gtttagaaag ctccatccca ttgacctcgc cgcctagatt cagatccatt aaaatgagat 2583421 catatgacga gaaatcatgc tgcttgataa actgttcgct cggttcagga ctgagacaat 2583481 caacagacaa attcgaatcc gtttccaaaa ttgtcttggt gccttccatg acagccggat 2583541 ggtcatcaat cactagtatc tttttcatgt tttcctccct tttactcact cttttccatt 2583601 ttataaaaaa gacttggcct gtgccaagtc gtttccgtta taaatccatt acaattcgat 2583661 ttcaatatca gccttaaagc cctttccttc acttgtttca atccgaaggc gcccatctaa 2583721 agccctgact ctctccttaa tgccagaaag ccccatgctc atggaatgct cagtattttt 2583781 ttcttgatca aacccaacgc catcgtcctc ataatgaaga acgattttgt tttgaatact 2583841 gatgagcata atcagcacat ccgtcgcctg agagtgcttg accgcattag acagaaactc 2583901 ttgaatgatc cggtacaaat tcagctgcga atccagatca agggaagccg taaatctccc 2583961 ggtatttaaa cggatatgaa acggaacccg ctcctgctgc tgcgccacca gcttcgacag 2584021 cgccttcacc aatccaagat catacagaag ctgcggccgc agctcatgac acgtctccct 2584081 cgtcatcgaa atcacatcag acatctgctc attcatctgt acaagcttgt cctgcacctc 2584141 ttcacggcac ggattatcat ccttcttgaa atcacccaaa aacagctcac actggcgttt 2584201 taaggaaatc aaatcctgaa gaaccgaatc gtggagatcg cgggcgagtc ctgaacgctg 2584261 tttttcttcg attgcaaaca ttagcttttt cagccagatg gggttggttc cctcttgttt 2584321 taagtccttc aaatgttcca tgagctcctc aatatgcagg acattttcca tggacacact 2584381 tgtataaaaa gacagtgttt tcagccacga tatttcatca cgtgttagcc ggggagtgtt 2584441 aatattagat aaacaaagca gaacataaga actaccgcct cgttcaccaa ctttcataag 2584501 aaagccttga ttgacttcta taattttccc aatttctgaa gttacgtttt caaattcctc 2584561 ttgataaaaa ttccagtccg gtccaacttc atgcttatct aaaaatatca ctttgtgatc 2584621 aggagtaacc tcaaaggtat aagctttgct tacaagcaaa acatccagta tagtattttt 2584681 cagttcttta aaaacttgtt gaagagaagt tacacccctc attagctgag tatatttaaa 2584741 aatactgtcc tgatagttga atttttcgga gaaacgtttt aaccgaaatt taaaatccat 2584801 gacctcttta aaataaaaga cagcgaacat gacaacgaaa aaaaatacag tttgacgcac 2584861 agggttcatc tggatgtcca ttacatcaaa cagaactaat gcaccaacta ttagaagagt 2584921 tggtatcatg gcaagtagag catagtatct cattcttcct aagataaact ctatatcaaa 2584981 catcttattg gctacaaatt ggtatactaa cccgaacgga attagtacta gtaatgacgc 2585041 cgaagctaat gccgggaaaa tataattacc tgtaaatatt attggaagaa caaaaaatat 2585101 caaaaaaggc gcaaatgaaa gagtgtttgt taaaattagt aatttaagaa taaacgaatg 2585161 ctcagcatat ttatatttat taagatgtaa gtatatcgct gaaaaagaaa atagagtcaa 2585221 agttgcaaaa gaaaccaaat taagagttgc taaaaaatca atatctactt gtaaatagtc 2585281 ttgaaaaaac tcaataccaa gattaaatat tggtatgata taaagaaaag aaattctatt 2585341 caaaaaagtt ttacctattt ctccaaggta tctttgtata aattgaagat aaagaatagg 2585401 agaagatata aaagtaaaca agttaatata ccgattgatt atatgtcctc taaatggtcc 2585461 gcctgcactt atatatgcta tcgaaatgtc taataacaat agaataagaa tataggcagc 2585521 aaatgatctc ctttttttat ttactttaag tatataaaaa atacatatta tgcttaaaaa 2585581 ataaaaaaac aaaggaagta cgaacagaaa aaaactataa ggtctattta gagtaactaa 2585641 atcaaaatct ttgagatgaa tcttttttcc acttctcaaa atatccagac tgttaatatg 2585701 actcaaatat ccccatttca aatgtttgtc tgaaggtttt tctttattaa tttttaatat 2585761 gatgtctccc tgtctcagac caacaaattg tccatatgaa gattccgata tttcttctat 2585821 cataaattga cttttatcat ttttatgaat cttagtccca ataataattc cattcatact 2585881 gatataagtt gtatagctta tataaaggat actcaaaaca attacagcta ttgtgaattt 2585941 ttttattaag ttcttcaata ttaatccacc tattaatcac cccattgacg ggttattgga 2586001 tcagccagat aataatcatt ataagcttta attattgttt cagtttcttg cacatcaaaa 2586061 cctataaggc aggcttcttt atttttcaat ttttttaaag cctcaggata atttaaaaag 2586121 tagttaatta ggtcttgcat cttgtatccc cctttgtata acttaataag cattccttta 2586181 ttagctcttt ttttctttat ctaaatttaa ttgttctata gcagaaatac atttctgttt 2586241 atatatttcc aataataccg aaatgtattg agtaactccc gctttaatta atttttcttg 2586301 gaatttctct ttatcaagta acgatttata atataagtct ttatgtgaaa ttaagtataa 2586361 taaatcttcc gaagcatcat taaaaaggcg cttaagatat aagtaaatca gtgtatgttt 2586421 gtttttttca atatcactgc gatttccgga taaaagaaca taataatctc cagaaatttg 2586481 agctataatc cctttatagt aggaatatct ttcaactgtt tcattatatt ctcctgtagc 2586541 caataaaaca cctgctacat ttgctagtgc aatcagactt ccacatttta atctaattac 2586601 ttctaaactt tcatcttctg ttttagattt attagtgata tcgtcatgtt gaccttgcat 2586661 ggcctcgttt acgtatttta aaacatattt aaaaattaga ggattgttat ttaatgaata 2586721 aatactcgtt aatcctactg tatacaagga aagtgctgca tttaacgact ccgagcgatt 2586781 aattttcatc cataatgcat ggtgattatc ttcatcttca agatcatcca taatatctga 2586841 tgaaagaata agaatttcta ttcccgcgcc aagccttgtt gcaacatcta aattctcccc 2586901 tccaaaaaca acataatgta agattgtgga ttcagcaaag gagaatgttt ctttagaatc 2586961 aataaatgag taaagaagtt gtgacaaatc ctcgttaaat atgttttgct ccacaatctc 2587021 cttcattttc tccttgatcc ggacagaatc taaacatatc tgctcaataa cgacttcccc 2587081 cctcccattc cattttacta aatgggacat ttaaaggaca gcaggttttt cgttttttaa 2587141 caatcatata atactttatc catttattgt atcggtagaa cgaaaaaaaa gacttgtttc 2587201 caagtctttt tcacgaaatt ttcattgcat aattgtattt atcgagttga tcaatgcttt 2587261 tgttaatgtt tcgtaatgaa tctgtcgttt ctttaatatc aagttcgagt cggaataaca 2587321 attgttttac ttcttcaagt ttcttttcca tcgtttccac actccttttt ttgaaagatc 2587381 aatgaattgt gtatggtgaa cgagtcctag gtatttgatc tgttactaat agtgtgtctg 2587441 ctttcggctc atttttcacc gaaaagtatg caaaaaagtc ctgcgtgaca ccgcaaatct 2587501 caataggtcc ttatactcaa aggaatcaca acaagaacgg gactatcttt ctatgcgaaa 2587561 gagcgtttat atgtgctgaa attgagaaag attcttaatc tccttgattt taacgggttt 2587621 cgcattttca ctaagcaaga ctatagtcct tcataccgta ttttcaaaat tgaatatgcg 2587681 attcttggcg tttcctgacc gacaaacacc gaaaaagacc gcaacgctaa agttgtggcc 2587741 ttttcgcttt gtcatattcg gcaattaggg atctatacat atagaaacat ccttttttgc 2587801 gaggtgctcc catgagatat cgttatccct ggttttacgt gtatccgtat gaggtacgcc 2587861 gtccgcccgc tcctgccaac aatattgata cctttatccg ttcagcgaag caggccgcag 2587921 ggatatttgc ggatgcccag ctcgttctca gccgcattgc gggctcgcgg gagctttcgc 2587981 gccgcattct gaccgcagcc gaacagtctg ataaacaaac tataaggcgc ctgatcaaac 2588041 aaatgggcgt ccggcatgaa gtggatacgg tctttaatcc cgacggcatc tatatcagcc 2588101 ttatcggaac gcaaagccga atgattcttg ctttgcggtg gtcagaggac cgcaatcatt 2588161 ttgcgtccat aagattatga caccattcca gagcctctaa ataacattca tacgcttctt 2588221 ctttgtccag ttgattgcct aattctgagc aagtgtccca gttgttgctt tcaattaatt 2588281 tcacaagctc aagcatttgg tagtagtcgt tttgatggcc taataatgct tgcccgactt 2588341 catcttttaa aggcaattct tgaacaattt cctctatttc tctatgcagg agggtgtcta 2588401 tgagagaaaa cattccgatc agcatataag aagcaggctg cggccgggat gtctttctcg 2588461 ccagcagttc gcaaagcttt gctcttatca gagaaatctt aatgatttcg tgcttgctgg 2588521 aatgcccttt cctgcttaaa tccttaaagg aaagaatata tatccaccgt ttgatttcat 2588581 taaatcccag cagcataatg gcctgttgaa tgctttcaat tttctggctc aaacggctgt 2588641 gggatgagtt taaaaatttt aaaatttgat aggacagtga taaatcccgc tctatgtact 2588701 ctgtcacacg ctttatgtta ggctgctctt tactcagttc gttaagcagt tcatagtaag 2588761 aatagaaatg agtcgatagg tcatgcccgc tgatgatgcg cggctcgctg aaaaagtagc 2588821 cttggaataa ttgaaagccg tcttggaccg cctgtttata ttcttttcgg gtctctactt 2588881 tttccgctaa aaaaatcagg ccgcggcagc cgtaggtttg caaaattgtt ctgcgttcca 2588941 ttcgtgttgt tttgagaaaa tcaattttca atatatcaat atagctcatg agtttttcca 2589001 gtaagtcctc atcttgcgga tttattgcat aaaaatcatc aagcgccagc atatacccca 2589061 tttttttcaa ttctttgcat ctagaaatga gggccggcgt gatcggtata tcttcaagga 2589121 tttcaatgac aagctgtttc ggattgaagg aggtgggaag attcgaaaac atcaggcttt 2589181 ccgtaaaatt aacaaaacag cgtttccctt ccgtcagctt ctcaattccg atgtttaaaa 2589241 agctgttgat caccaaatct gttgttgcct gatcgccgtc tttagcgcta tacacgttct 2589301 cttcgctttc tctatacagc agttcataag caacaacctg ttcttttcta ttaaaaatag 2589361 gctgtcttgc aacaaacacc ctcattgatt tatccccctt acaatacgcg cggctttcac 2589421 ccctaagtat atcaaataat ttgacgaaaa ttgtctaaac atgaaaaata atatatacat 2589481 aaagaaaact ggcccttcgc gaatgaaagg ccagtttttc tttattcttc ctcaagctct 2589541 tcttcaattc tgcttttcac ttcgtggatc cgctgcattt tattgctcca gcagtcctcg 2589601 cttaaatcaa ccgggtattc ctccggcttg ctgattctct tatattcctc ccaaagcagg 2589661 ctgaggttat cctgcacata ctgctgtatg tctgaaatct cagggttttg gtagcaaaga 2589721 atacccttct caaaaatcag ttcatgaaga tccttcgcat aaaaattcgt gacaaatttg 2589781 ctgatgaatg tatgaaccgg gtggaacatt ctgagccgct tctgatcatt cacctgctca 2589841 tcataaagcg caatatagtc gccttcagaa tgatggttgg actgattaat aatgcggtag 2589901 actttctttc tgcccggtgt cgtcactttt tcaggattgg acgaaatttt gatcgtgtcg 2589961 accattttcc cgtcttcttc aatggcaacg agtttataaa ctgcgccgag agccggctgg 2590021 tcataggcag tgatcagctt cgtaccgaca ccccagacat caatgcgcgc tccctgagcc 2590081 tttaaattca taatggtgtg ctcatccaaa tcgcttgaag caatcacctt cgcatctgta 2590141 aatcctgctt catcaagcat tttccgggct ttttttgaca ggtacgccaa atcgccgctg 2590201 tccagacgga tgccaatgaa attaatgcgg tcgccgaatt ccttggcaac cctaatcgcg 2590261 ttcggcatgc ctgaacgaag cgtgtcatac gtgtcaacta agaagacgca atccttatgt 2590321 gtttccgcgt attttttgaa agctgtatat tcatcgcggt aagcctgcac aagcgcatgc 2590381 gcatgtgtgc cggaaaccgg gatattaaag cgctttccgg ctcttacatt gcttgtcgcg 2590441 ctaaagccgc cgattaaggc tgctctcgct ccccacatgg ccgcatccat ttcgtgcgcc 2590501 cgtcttgttc cgaattcaag cgcaacttca tcaccgatga cgcctttaat ccgggcagcc 2590561 tttgttgcga ttaatgtttg atagttcaca atgttgagca aagctgtttc aatcagctgc 2590621 gcttctacca ggggtgcctc caccctcata atcggctcat tgttaaaaac gagttctcct 2590681 tctttcatgg agtaaagtga acctgtaaaa gataagccgc gcaaatattc aataaaatct 2590741 tcatgatacc cgagttcatc ctgtaaataa ctcaaatcgc tatccgtaaa cttgaaattt 2590801 tccaagtatt caatggcttt ttccaagccc gcaaatacgg catagccatt ttcaaacgga 2590861 agccttctga aaaacagctc aaaaatcgct ttcttttcat gaatgccgtc tctccagtac 2590921 gtttccgcca tattgatctg ataaaggtct gtatgtaatg acaggctgtc atctttaaat 2590981 ccgtactcta acactgtttt tccccttcct tactctgcca cttgcgctcc gatgctgttt 2591041 gcaaaatggg aaagagccca tgcgtgcccc tcctgattaa agctggcaac agcttgttta 2591101 tgcacaacaa tccgaaaacc tttgttgtat gcgtcaacag ctgtatgcaa cacacaaata 2591161 tctgtgcaga caccggcaag atgcagttcg ccaatctgcc gctctctgag tttgagctct 2591221 aaatcagttc ccgcaaaagc agaatatctc gttttttcca tgtagtaaac attaggttca 2591281 tgttcatgtt tctgatatag aggcaaaagc tttccgtaca gatcttttcc ttccgtgcct 2591341 tttatattat gcggaggaaa aagacgggtt tcagggtgat attgatcccc ttcatcatga 2591401 gaatctactg ctaatacgac gtaatcaccg tttgtgatga attctttagt taaattgacg 2591461 atcgcctctt caatcattct gccgggctcc ccgcaggtca attttccgtc actcgccaca 2591521 aaatcattcg tataatcaat acaaataagt gcttttttca tagccggcct ccccgccatc 2591581 agtatgagaa cattatatct tatctccagt tgtaagtgaa ttgccatgaa caaaaagaca 2591641 aacggtccgt ttgtctctta cgatttcagt actgaccgat tataaatgtc gtcctgaata 2591701 tatatcaatt cacgattcac agcgatatca gccgcaatga cgatgcctaa gggcgtatga 2591761 aactggagat cagatacaat cttgaaaggc actccgtacc ggctcgccat ttggatataa 2591821 gaagagtaag actgatactg aagctctcca ttaatcaaaa gggtgacgtt atggctgttt 2591881 ttcagctcgt gctctgcctc tttatacggt ttgcttctaa gcacctgtcc tttcgtcagt 2591941 gccaaaacga ctctttctct taaagagcct aaaaacaaat ggcgctcgtc aggctttgtc 2592001 tccaaaggcc catacattcc ttgctgcaaa tagagatcca ttttatcttc actcaaaagc 2592061 ctgtcctccc gtcttgtttg tcttcattat cacctgatca ggcaggagct aaactttcaa 2592121 gcgccgttta catttctgtt acccaatgaa tgattttttt ggccagctca ccagcagggg 2592181 tttcctctgt atgccggcgc aacgacgctt ccagccgttc aggcagagtt gctttatctt 2592241 cttcatagga aatgatcgtg ctccactcca gctgcggtac cgctacaagc gtgcgcagtt 2592301 cttttctgtt ttcatgcaga tacacgtccg tgatcattcc ggtttgcgta ttgatatttg 2592361 cttttctgat tttcataaca tgacctctct attcaaagac tacccatatt atacaataaa 2592421 aaagcaacag cctcttgtga aaaggctgtt acccgttaaa cgaaactgtt tcatcagtga 2592481 tatcggcatc tttgaagaga gttttactcg tttggttgtt aatcttcaca aaatcaccaa 2592541 gctgaaatgt gcctgacccc gcccctgaat gagcgacgct tttgggcgaa atcgcaaata 2592601 cgtctccaaa gcttgccgcg gcattatccg taactgacat gatataaatc ggccccacaa 2592661 ttgcaggcat ttccccacct ccgcattgat ttacagcatc atatgcaagg agccgataat 2592721 ggtgcccgcc tattcagctg gctttgcgtt ttcctcgagt cgtgaccgct ggcgcagctt 2592781 gatcaagcgg acaatattca ggaagaacgc cttcactacc gcataaaccg gcaccgctaa 2592841 aatcatgccg agaattccgc cgaagcttcc cgctccgatt aatagcaaaa taatcgtaag 2592901 cggatgggta ttcagccgct ttccgatcac aagaggagac agcaggtttc cgtccagctg 2592961 ctgaacgatg acgaccacaa taatcgcaaa cagcgctttg gccggcgagt ccataaaacc 2593021 gacaatgaca gccggcgcgg caccgagaaa aggcccgaca tagggaatga tattggtaat 2593081 cgccatgaca atcccaagaa tcagggcata cggcagtccg gcaattaaat agccgataaa 2593141 acacgctgtt ccgacaaaaa gacagattaa cagctgcccc tggaaatatg ccgcaagcgt 2593201 atcggataaa tctttaaaaa tctttaagcc ttctgtccga taagaagccg gtagaatttt 2593261 tactgccaaa tgcggaaagc ggtgtccgtc tttcagcatg taaaaaagga taaatggaac 2593321 agtaataata acaagcgtga tgtttgtcac gacaccaaac accgcagata aactggacgt 2593381 gatattttgc ggcaggtttt ggagaaaact tgtcaatgac tgttcaattt ttgatatcga 2593441 tacataatcc tggttcatca tccaggtaaa ccattgagaa tgggacaaat cctttgtcag 2593501 cgcctgaatc tgttttatat aatcaggaag gttgttaaac agccctgtca cctgtgcggt 2593561 gatgataggt ccgactgacg ctgaaataaa ggcaagcaaa ccgataaaca gtaaatagat 2593621 caatagaatg gataatgtcc gcggaatttt tttctcaagc aggcggacga ccggattaaa 2593681 tatgaaatac aaaattcccg caattagcat cgggaaaaac aatgtcgaga taaaaacaat 2593741 aaacggctga aatacaaatg aaacttttgt tgctacaaaa ataatcagca aaacaaataa 2593801 aatctgcaat gtccaaaaat ggacttttga tttcaacaag ctttgttcct cctagttttt 2593861 ctttgtctgt cagataaaag aacttatacc ccatcattgt aacaaaaatg aactcatatc 2593921 agaactctta atataatgaa aggagtgttg gtgatgaagg ccgtgacata cgatacagat 2593981 tcagaactgg cttatatcta tgttcttcct ccgaaaaaga acaggaatgt acggactgag 2594041 gagctcagag tcaatgattg tctcctgctg gatatcagcc aagatggcaa aatcgccgga 2594101 ttcgaatgtt ttggtgaggc agcacacctc tgtgccccat ttgccgggaa atcccggctg 2594161 tatgtaaaag attcagacgg ttatcatttt cgggtctgcc agcatgcttc agtccgttcc 2594221 tgctatacgg tgtaccgtgt cactttctgt ttttcagatg gtgactatca ggaatttgcc 2594281 ggctttgacc ttgatggaac aatgtatcat agtgcgtttt tacagcgctt aactgaaaaa 2594341 taggacgtcc tgttgtacgc ctatttttca tgcgcaagca ctgttagacc cgctcactgt 2594401 aatctggggt gacggaaatc atgtgctgga ttctgatcaa acaaacagaa tttcgggctc 2594461 cttcaattgt gatatggtca ggttttacat cgatcagtct gcctctgacc gtatctcgta 2594521 ctgtctgtat aacgaacctt gagccgatga gctttttaat ggtctgatag acataaggat 2594581 cgactaaaga gaccagttgc ggactacctt ggttgaccat acttttatcc cctttgtgtg 2594641 ttttatctca gcttatgccg cgcttatgga taatgacaca ggcttacctg ataaaacaaa 2594701 ggggtgcgga gattttagga gaatacgttt ggaggcgggt gtaaaggaag tatcgatgaa 2594761 gcggagacag cgaagaaagc tggcgctgtt ccgtacttat acaggcttta tcacggatgc 2594821 ctgggcttgg tcgattaatt ggtccagctt ttctattttt tttcgtgcgg ttgaaggatc 2594881 aatttggcgg taatgatggt ggccgcccgg ctcttcatcc agttcgtccg cttttttgac 2594941 aatctgctgc agtgtgtttt tatctaattc gccttcaggc aaataggaat ctgtatgaag 2595001 caaaatggct agtgcaatct cttttgctgc tttcggttcc tcgccaagcc gaatcagaag 2595061 tttatgcgcc cgttccgccc ctttaatggc atgaatgtca tttcttttgt atttctcata 2595121 atcccacttt ccgtctgtat accattcata atggccaatg tcatgaagca gtgccgcttt 2595181 tgctgctaaa tcaggattaa tgtcagcctt cacagacagc ctgtatgcat gataagcgca 2595241 ggcaatcgca tgtgccacgc cggaacgctg aagatatttt tgtgcaattg gatgggtgaa 2595301 aacatccatt aatgtaacct ttctcatgga aacccctcct ttagatattt ttagaatcct 2595361 aacataattt gcagagaaac tcaattctta tgtcacatca ttttgatctt cttatcatca 2595421 ttgttatacc ctaaaagcaa cgtttcagtc agtatatgcg gctgttcaat aaaatgcgct 2595481 ggctgcagcc ttttgtataa aaaaaagagc agaaaatatc tgctctacaa aaactcttta 2595541 atatcataaa tgcggccgtt ttccgtccct ttttctagta aagaaagcag cgtgccggca 2595601 ataaagtccg gactgcgaag gcttcctgtt tcatttaatt tccggaatcg ttcaatgtgg 2595661 tggaaatcct ttttcgatga agaacggatg acggcctgca tctcagtgtc catcactcca 2595721 ggtgagaacg aaatcatgtt caccggcagc tcttcatcct cctgttcaaa tccgaatgtc 2595781 ctcgtaaaca tgtcgagccc ggcttttgaa ctgcaatacg cgctccatcc cttatatgga 2595841 tttttggcgg ctcctgaagt aatgttgaca accgtctttt tgccgctgta tgaagcaaac 2595901 cgttttgtaa acagctgact caaaagcacg ggcgcagtca ggttcagctg ataatggcgc 2595961 tgaagctcgt caagagacgc ttcgccggca cgtttgatcg gcgttaccat tccggcgtta 2596021 ttaataaggg taataccaga ataacgatct gaatcgatgg atgagagcaa tgtttcaaat 2596081 tgctgttcag cttcttcgag attgatgagg tctatttgat gctgcgttag ttttttgtga 2596141 gagacatctg ttttcgttct ggataaggca tggacttcat gccccttttc taaagcctgt 2596201 aatgcaatgg cttgacccag cccttttgac gctccggtga tgatataaag ttccattgga 2596261 aacctccttt tccgttatta ttgtacggca cctcttttac acaacacaag cacgcggcct 2596321 acgccttctt gttttcctgc gctgtgactt ttgggatgag gaacacgatg cctgcaattc 2596381 cgagcaggat cagtacgaca tagatcatcg gcagcagcaa tgatgatgtt tcttgttcat 2596441 cttctgtttc cgttgatgat gtctttgtca ttggtttttc agcaaaagta attccaagct 2596501 gtttcgactg ggccgcaatc gtgttggaat cctcggcatt tgttgatgta aacaaatctt 2596561 ttatcagctc ggcgtccttg tccttcggtt tatcaaaagt gatatccttt tgttcctcag 2596621 gcagttctgt tttttcttca tagtaggtat cttcatgcaa ataattcgta tcgatttcga 2596681 tgtctttttt ctcatactgg tttggcgcga catctgtatt ttcttcagtt tgggcagccg 2596741 ctgcagaggg tatgaaaagg gaaaaggaga gcatacaaat catgatcccc ttttccatgc 2596801 tgcgatcacg cttcatacgt ttcatcgctt tctgctgtgt gttcagccat caaccggata 2596861 atcagcggca gagccacggc aatcaccgta atgatcagca gaactgttat tcccattgta 2596921 aacaagtgcc cagtaccgta ctggatgtcg atatatactt tcgaaaccgg atcttcaaat 2596981 gtaaagttcg gcatgatcaa atcaataagc ggtgcgacat agaataggat cattgctgct 2597041 gaagcaaccc agccagggat tgatccgaat ctgaatgccg tccggatgaa ggcagagctt 2597101 gcgaccagca atagaatcgt aaacaccgac cacttaatcg tctgatcgtc cggcagtgaa 2597161 taaatattca agccgaacaa gctgatcata agtccgacaa ggatattcag aattccgaat 2597221 aacgctcctt tgacgagaag cggtgcgttt tggtaatacg agctgaaata gccgattaac 2597281 agactgctga tcaacacaat gacaaggatg acaaccggag gtaccgtctg aattttttct 2597341 tccggaacct ctccgctgat tttaagcgga ttcgctaagt aatcatatac atagccattg 2597401 ttttgcccgt ctactaatgt atttccgagt atgccgtata cgtcatttcg cacgagtttc 2597461 gtggaggcga catttttccc ccagttgttg tttaaggtgt cggctttcgc ttgaacatca 2597521 ttaacgcttt gctgcatgtt ggttgtgtaa tcaatgatgc cggactggcg atcagacaat 2597581 gaacccatca tgtctgacat ttgcagcact tcctggccga ccgtatcttg gacactcagt 2597641 gccatggtac cagacagccc atcgttgctg aacgtcgcag attcctgtgt tgcgcccgtt 2597701 acaagctgtt ctgacgcttt tgcggcactt tcagagattt tcgtcagttc gtcgagaaca 2597761 cctgcttgag agtcacggat atagccgctg tagtcgtccg caaatttggt catgccgtcg 2597821 atgaagctgt taatatcctc atctgtttgc atcgtgttgt ttttgagagc ttcccagctg 2597881 gctgattctt caggtgtgag agccaggact gattggacgt tgccatcttg ctcttggatg 2597941 acttcacctt taataatagt caaagagcct agatccagat tatcatttag cgtagactta 2598001 tataaattta aagagttgta atacttcatc aagttagaaa tattatcagt ttcaattcta 2598061 cttgaaaaaa ttgaacttag tttttctttc tgatctatat agcctctact ctgcaaagtt 2598121 tgtattattt cgtcttccaa attgtatatt aacctataag catcattgac attattatca 2598181 aaatcaacca acttttttgt taagtcacca atttgatcat ttaattttga aactgtttta 2598241 tttaactctt taatttcttg atttaactca tcaatatgtt tctctagttt gttgttatgt 2598301 tcctcttgtt tttcttgaag tgcattttct atttcctcta attttatcgc tgcttcgttc 2598361 agacgttttt ttgcacctga aatatcagtt tcaccgtcag ctccgtcacc ctgtagccca 2598421 tcactttgat ttgagccatc gttttcatct gcgagttcaa tcaaagagaa atctgtttta 2598481 gaggttcctg tattctccgt gtttgtatct tgttcaggaa cgttttttga agattcttga 2598541 tgtttttgtc ccgtttcaat gttagtttga acatcatttt gtgatccatt atcttgagta 2598601 ccctcttctg atgagccagt atcttcattt gttggctgat catcggatgt tggaatatca 2598661 ttcgacggtt cttcagtatt aggagaatca tcggttgatg gttcttcagc atcgggtgtt 2598721 gttggttttt cttgttcagg ttcttttaac ccttcagaga tatctttaat ttcagttgca 2598781 acatttttga gctcatcccg ctgcttctct aaatccaatt ttatatcttc aatatcttcc 2598841 ttatctgtgt catctttatt atcagatgtg tcttctccat cttccttttc gtcgctttcc 2598901 ttaggtttaa gtaaactaag gcggttcttc ccgatattct cttgcaattg atttaaattt 2598961 tgatatttaa tagcttcata ttgactttta tatcgagata gaaatgcatt aaacatgtca 2599021 ttctcaattt ttttcatacc catttcttgc aatggcactt gattttgcct taacttttca 2599081 gcattgttca acgcaaggtt tgtcagtcct atttgtgtct tcgcttggcc gatcccggtt 2599141 gccaatccgc tcatgcgttc gctgaactga ttcgcctttt gctgtgcctg gatggcatcc 2599201 agacctgtcc ggatttgctg ctgtgttgaa tcctgggctg ccaaaagcag ctttttctga 2599261 ttctcttgat attctttgta cctttcaact gtatcaatga attctttcag cgtgtttttg 2599321 gcttcctccg ccgtagaagc tttttctttt gtcgtgcctt gcgcttcatt cattgatttc 2599381 ttcagctcat cgattaagtc tttttgctgt ttgatttcac ctgctaaatc attagagctt 2599441 ggtttgtaaa agttgtacat gacattctgg aattcagatt ctttattgac gatcttgtca 2599501 aattctcctc tgatgttgtc cactttttgc gaaacaaaat tccagtataa ggccgacatt 2599561 tttttgttca ttgtcttttg ggcatcctca agctcacgct gaactttttc tttgttaacc 2599621 gcattcaggt tatcttgaat gctgaattcg agcgttgcct tttgaggatg gtctttgtca 2599681 tagctcaaaa tgttttttga gaagtctgag ggaatgtaga caatcgcatc gtatttcttt 2599741 gaagcgagac cggtctcggc cgcgcttcgg tttacgaccg tccacgaata atcaggacgt 2599801 tcacccagaa cggccgctac ttccttgccg aactgggcgg atttgtcctc ttcatcagac 2599861 tttacctcat cactcaatac gcctgtgtct tcattcacca ccgcgatttg ccgggtagaa 2599921 ttgactgctt ttttcgttgg gtcgtctccg ataaatcgga aaaacaacac cggcagcagc 2599981 aaaatgatga tgacggcgga tattaacttg atcaagcttt ttcgttgttc tgtcatctag 2600041 cactctccct ttcagcagaa cataaaggaa tttgaacttt ttgctccttc ccgttttcca 2600101 caacatatcc gaagcccggc tgaatctcag gctcctgtct ttggtacggg agaggaatga 2600161 cattttgctc agactttttc atcagcagaa tcgcgtggcg gatttgcttc atctcagtcg 2600221 tcaaggagtc atagcctttt gagaattcgc tgtggtttcc gcccgggata aagctgaacc 2600281 caagatgagc gtatgatttc atgaagttag cgagacgatc ttgtattctc gtatcaatcg 2600341 tctgctggaa tctcgttatc ccgtcaatca tcagcacgac ttgtgagaat cgcagatttt 2600401 gtgcgtctcc ttggcggacg gcttctacat acatggcttc tcttgttttg aaaatgtctt 2600461 ctgctgtttc aatccactgc tcaatatctt ctttcgtttc caaatatgaa acatctgatt 2600521 ccttcgcata atgagataag ccgcggtcaa tcgagtcaaa caggccgatc atttcggttt 2600581 catcatcaat cagatgttca agcatgactt ttaggacgtt tgttttcccg cgctgagttt 2600641 ggcctaaaat caggcagtgc ttatgcttgc ccaaatcaaa atagactggg ctgactgttt 2600701 cttcatgaag cccgatcggt acagataaag gcttgcgttc cagcttgaag cggatagaca 2600761 attctctcgt cgacaagctc tcaggcagca tcggaatcgg tgccggctgc tccattgaag 2600821 caaatcgccc ttgaagtttc tgtacgtctg atttcagctc gttgaacatg ccgatatcat 2600881 catcggcgtc aacaggcagg aacatttgcg cgaaataaag ctcttccttt tgaatgatga 2600941 cgcgtcccgg aatcggctca agattgaatt tcggacggcc gtaaatggaa tatccttctg 2601001 attgatccat gagataatgg acaatctttg ttttcaagtt atttaacaat gactggcgga 2601061 cagcattcac ccgcgttgct gtcagcataa agtagatacc caagctttgt ccgtctctgg 2601121 aaagctggac aaattccgat tcaagctcat gcatctcatc cttgacaatg tcaaagttgt 2601181 caatggtgat aaaaatgaat ggaagctctt cttcgctcag cgcattgtac attttgatgt 2601241 ggctgatttc tttttcccgg aacaaacgtt tacggcggtc aatttcttct ttgatgcgaa 2601301 tcatgaactt ttcaattttc cttgactggt ccatcaggaa gtaatccgcg gtatgcggga 2601361 gcttcgctaa tggcagcagc gttccgtttc cgaaatcaaa gatatagaca tgaagctctt 2601421 caggtgtgta tacgtccgca aaactcatca ggaacgttgc ggctgcaatc gattttccgt 2601481 agcccgaaga gccgaagatg ccgatatttc catcttccat catcttataa gcaattggcg 2601541 cctgtctttg cagatcaggt tcatcgacat acgcaaagtg gaaatggtct ttttcgtttg 2601601 aagggaaaag agtgcgcgga atacgttccg caagcggcgg cagccaaggg cttggcagct 2601661 tctcgattcc catttcatct tggatgcgtt caatttcgtc aactacagct tcgatttcgg 2601721 tttgaacgtc ttttttcgcg ttatcttcgg tatcaacctc agaaagcggg atcagacccg 2601781 tatctgtgac gatcgcgatt tcatcctcgg taccgtagac ttcctctaag taaggcgccc 2601841 cgctccatgc agattggaac agctcataca cttcattgtt tccgacctgc aaatagccgc 2601901 ggcctgttac ggtaatgttt gcggcatcgc tgtttttcaa aatttcttta ctgtcggtgg 2601961 catcctggac cttgagcgct actttaaagc gcgagttact ccagatctgg tcgtcgatga 2602021 tgccgcctgg cttctgtgtc gccaaaatca aatgaacgcc gaggcttcgt ccgatacgcg 2602081 cggcactgac aagctccctg ataaaatcag gctcctcgct tttcagctcg gcaaactcat 2602141 cagaaattaa gaacaagtga ggcatcgcca cttctgcttt cccttgcttg tatagctttg 2602201 tatagtcatt gatgtgattg acttgatact ggtcaaacag gcgctgcctt ttttttagct 2602261 cgcttttaat ggaagcaagc gcacgcatac tgaagttttt gcttccttca atatttgtga 2602321 tcgtgccgag gaggtgggga atgttacgga acggctgcgc cattcctccg cctttatagt 2602381 caattagtaa gaaagccgct tcatgcggat gaaaatgcac tgcaagtgac aagatgtagg 2602441 tctggagaaa ttcacttttc cctgatcccg ttgtccccgc aagcaagccg tgcggaccgt 2602501 gtgctttttc gtgaaggttc agatacacaa tgtcatcttt ccctttatag ccgatcggca 2602561 ctgacagcga cttcgacgat tcacttgtca gccatctttg ctgaatgccg atttctttta 2602621 cttccttcgc atgaaaaagc tccaggaacg ataccgtttc cggaatggaa ttcgtaatgc 2602681 cgacctggtg gttcagcgtc cgcagtgtgc gtgaaaaccg ttcgttatcc tcacgctgat 2602741 gatgatcgag acggaacgga attcttaccg cttttttctt ttgtattaaa atgtcgcctt 2602801 catgctcatt aatgtagcgg acaagagttg taatgttttc cgacaagctt tcctttgttt 2602861 ctgcagcgac aattgtcgag atgcccagat gctcatgctg cccttctaaa tattcgagaa 2602921 tgacatgctc agagatcagc tgctgattcg tgatgacaaa tacaaaatgc ggtttgaact 2602981 gcagtttttc tttgtcatct tcgagatcac gctctctgat caattcgtaa agtgaagaca 2603041 ggagctgatc tcgggtttgc tcattataaa taaatccttt tgcataaata tggggcattt 2603101 gaaattgcgg aagccacttc atccactccc agtctttata ctcttcttca tgaaaaataa 2603161 atacgaaacg caaatcgtga tagctgttaa agaacgacag ctgtccgatt agctggtgaa 2603221 tctcattttt cacaatttgt gatttaccga caagccccat cggaccttct gccaaatcga 2603281 ccgtcaccgg cgcattacgg atatctttat agacgcgttg catgtgctgc gatttctcca 2603341 tgaggtcatc gatatcacga ttcgccaagt ctccgccact catattgatt tcatagcttg 2603401 acggaactgt tcccgtccca agccgcagct ggagataatc cttgctttca agtgattttt 2603461 cccagatccg gtcactgatt tcacttgtta agtatttcat ttgttcaaat gaaggaaagt 2603521 gaaattcaag aacctgcttt tgcttttcag caagtgcctg aagctctttc cgcttattgt 2603581 ctaagtaaag cttatataca cgctcccgtt tttcctcgcg ttttttccgc tggtttttat 2603641 cacggaaata ttgcactgtc gaggtaatga gagtcatcat aaacatcgcc aaagaaacga 2603701 gtataaatat gccgcgcggc tggatgatgg caactacgcc catcacgatc agcatcacaa 2603761 gcggaggcag gatgacgagc cacagccctc tgttggtttg atcgctctcc tgagagggaa 2603821 aactgaaaga aacgcggtca tccggcagat cgtataccat ccgcggcgtt cttctgtact 2603881 gcggatattt tttctgcatc tctgtactcg gtttgaccgt ttctgttaac gctgtttcaa 2603941 actgggcata atgaacaatt tctaaaaggt cttgttccgt caccctcatt tgcgtgaagt 2604001 tccagaatat ttcatccccc ggcttgagcg gcgtattggc gttgattttc tctccgttca 2604061 agaagatcgt tccgctttca gggcggaccg accagctgcc gcctgcacgg agcaaagaaa 2604121 acgtgctttg ttctgcaaat gcaaaatctt gcggattcag ataaatatct gcattcgttt 2604181 tttctgagga acatacaatt tcatcccgat ttcccgtaaa ataaacggat ttctcaggtt 2604241 cactgcccgt caatatcaag cgtatatcct gctgatccgt ttggagagta aatgatatat 2604301 ccgtctcaat cgtgccgaga caatcatttc ccaggaaaac ttcgtattgg ccgccggatt 2604361 cctttctttt aagagaaatc actccgctat taaatggaat ggtgctgatc gtaacagaat 2604421 ccttcacatc aggccctatg gtcaccggat gagacgacgg gaggttagac agatttaatt 2604481 tttgaacgtt attttggtaa aaaacccata atagactcaa atggcgaacc cccttacggc 2604541 cgaatggcag catgcgatga cctgcgcttc atgtctcacg ttatttgtca tcttttttct 2604601 catctttctt ttctgtttct tttttctcgt cttctttttc cttctgttct tcttttttcg 2604661 ctttttcctc ggctgcggct ttttcttctg ccgctttctc ttctgcttgt ttttcttcgt 2604721 ctgtttgtgt ctgttcttcg cttgtatcga ctaacgatgt ttcagaatta gactgtttat 2604781 tttcttgacg ttctttttgg gctttttcaa gctcactatt tactgaatca agttcttttt 2604841 gtatgtcttc atcatttgta tcctcagata aaagctgctg tttatattta gctagggcaa 2604901 agtaaatata atcattgtat tccagcttac ggccgatact gatcgcttct ttgtattctc 2604961 ctcgaccata atcaatccaa tataagaaat gctgagggtc tgattgaagg gtgactaaat 2605021 tattttctat atttttggtt tttgcactcc ccaggttttc gacctcaaca taggacgtcg 2605081 ccagctgata ctgcaccgat tcaggcaggc tttccgcatc gtacttggac agtgtgctga 2605141 tgacttcact gtactgcttg tttaagaacg cacggttgct gtccactatc gcctggtgct 2605201 ttggctgcgc gaaaaataag gcgtacatcg aataaataag tgccggtaca agcaaaacaa 2605261 tgagccccag gccgatatat cgctggatgt tccacttctt tctcgggata tgtatgtatg 2605321 tttttgcttt ggcttcgagc tcatcaatat gggtttgaat cagctcgagc aaatcatcat 2605381 aggattcagc atctaatatc gcctttgcct ctgcggagaa cgtcagcgtt tcattgaatt 2605441 tcaggtagtc ttcaaacgca aaagcgccgt caactgccaa agccgctgcc gctttcagct 2605501 cctgccatac tctttcctca tcacgctcgt aaggaggaat gctttctttt actccataat 2605561 ggagaaaata aggcgtaagc cctttatcga atacaatgtt ttcaggagcg acaatcaaat 2605621 tcagcctcga cagattgtgc tgctgtacgg cttgaacaag ctgataggca aactgccatt 2605681 tacttttttt atccttagct ttcatgaagc ggaatgcttt ataggaggag ggaggttgga 2605741 ttgtgatgat tacttcatca tccgtcacat cgatttcttt atgaaaaaat ggatttatat 2605801 ctttgatcac gttagcttca agaccgtcga gaagctttat tttttcccgt tgaaaggtaa 2605861 atgtatagcc ggcatctgtt ttctcggcaa cagcttctaa ttggttttct aaatatgatt 2605921 tttgttcacc tgacattcaa ccagatcctt tcataatatt tcaagccggt ctccgtttgt 2605981 aatgccgcaa tcagacagct tgcattctcc ggaaaacacc ttatccttgt tcaccactct 2606041 gatccagtgc ccttcgcgcg gaggcataga tacgctttgg gcctgccaag caatatcaat 2606101 tacttttttc accgggtggt aatctgacaa tctgagatca aagacactgc cgttataatg 2606161 tttcaaatct attgtaatat caatatacat ttaggatcac ccttacatag aaagagcgcc 2606221 gtcttctttt gaatcaggcg ctccttccct ttcatactgt tatccgcgga tttgatttgc 2606281 gatgtcttgg tcagtagact caagtgtatt tgctgtttga tcaagctgct gattcacatc 2606341 ttgaagcaaa tctgacattt tgataaatga aggtttgagc tgctcgtatt gatctgcgaa 2606401 cgcttcgctt gaagcacctt cccacatgct tttcaaatca gagatcattc ggtttaaacg 2606461 atcaacctga tttaatactt cttggctttc aacgccgtat tgcttcgcca tcgctcttag 2606521 ctcttcgggt gtgacacgaa ttaatcctgc catattcctc attacctcct gtgccatcag 2606581 cctaaatatg ggctaattca cttattttta gaacgtcatt attataaaaa cagtttttcg 2606641 gcatagtcaa acaaatatgt tttaatttta caaaatgagt ccaatggttt accccgaatc 2606701 actcaaaaat gacatatact gtaaagtaaa taggtttatt ttcttaatct tctcttcatt 2606761 ctccgaataa tccaaaagac ccaaataact ctccaactcc caaaaaaaac ctttcagaaa 2606821 atttgatgct acagcaccat ttctgaaagg ttcagttttt tctttcctta attagtcttg 2606881 cctccgatga ctttcttaga agattaatag gataagctgt cgtattatat gagacataca 2606941 ctgtcctgca aaaaggcgat tacaccgcca aatgtatata gaacgtttct ctcatgaaat 2607001 tgtttttttg cttctgttct ttgttgttga ttttcacaaa caacaacaat cataataaaa 2607061 ggaaggggat gagatgtcaa agagaaatca agcacgaaaa gtagggagat ttatgaccat 2607121 gccgaatgat ccgtttaaat atagttttga cagacttgaa gatgtggctg atcatatcag 2607181 cgacgttctg cggtgcccga tcaccataga ggatgttaac cacaagctgc ttgcctacag 2607241 tacacacagc gactgcacag accctgcccg gacgtctacc attattggca gaagggtacc 2607301 ggagaaggtg attaacaagc tgtggaaaga cgggacaatt cctgctctct taaaaacgga 2607361 ccagccgatc agagtcaagc aaatcgatga agtcgggctg agcaatcgcg tcgctatttc 2607421 gatttggaaa aacaagcaag tacttggctt catatgggcg cttgagatcc aaaaaacatt 2607481 gtccgatgaa gatctgctga cattgcaaat ggcagcaaaa gcagtgaaaa acaagcttct 2607541 caaacttcaa atcagaaaaa cgaaaaatga agaacgcagc caagaatttt tctggaaaat 2607601 gctgaccgga cacatccatc aggaggatga tatggcggat gggttccata agcttggaat 2607661 ggccgctcct tcagagtttt ccgttatgat catccgcata aatggcgagc tgactgaaaa 2607721 aatcgaacag cagctgcaat atttacagga aacgacccag caggtttacg tgctgctggc 2607781 gaccgtagat tccaatgaac ttattatatt aacctcaccc aaaacagatc atccttttca 2607841 agatttaaaa cagtttgctt taagtacgca aaaacagctg aaggagcggt ataaaataga 2607901 agacgtttct atcgcttttg gcggaatata caactctatt tcttttgtct cccgctccta 2607961 tcaggaagca ttgtccgtct taaaaacgaa ggaacggttc gctgaagaga ccaaacatct 2608021 tttcagcttt tctgagttag gcatttatca atacttagat gtcttaaatg aaaaacggaa 2608081 acaggcgggc cattataatt actcgctttc caaactggaa caatatgacc gggatcacca 2608141 gtcaaatatg gtagagacgc tagagcgctt tattgaagcg gacagcaacg tgaataccgc 2608201 ttccaagctg ttaaatatac acgttaatac gttgaattac cgactcaagc ggatcagcca 2608261 gatcgctgaa attgatttga aaaatgtgaa tcaaaaattc accatctatt tagatatcaa 2608321 acttcggcac atggatttgt gaaatttcac aaatccatgt ttttttattt tcttaatcaa 2608381 acaaagaatt ttccaaaata tcaagctaca ctaaaaatat cacatataca ggaggagaca 2608441 gatatgatca taggggttcc taaagagata aaaaacaatg aaaaccgtgt cgcattaaca 2608501 cccgggggcg tttctcagct catttcaaac ggccaccggg tgctggttga aacaggcgcg 2608561 ggccttggaa gcggatttga aaatgaagcc tatgagtcag caggagcgga aatcattgct 2608621 gatccgaagc aggtctggga cgccgaaatg gtcatgaaag taaaagaacc gctgccggaa 2608681 gaatatgttt attttcgcaa aggacttgtg ctgtttacgt accttcattt agcagctgag 2608741 cctgagcttg cacaggcctt gaaggataaa ggagtaactg ccatcgcata tgaaacggtc 2608801 agtgaaggcc ggacattgcc tcttctgacg ccaatgtcag aggttgcggg cagaatggca 2608861 gcgcaaatcg gcgctcaatt cttagaaaag cctaaaggcg gaaaaggcat tctgcttgcc 2608921 ggggtgcctg gcgtttcccg cggaaaagta acaattatcg gaggaggcgt tgtcgggaca 2608981 aacgcggcga aaatggctgt cggcctcggt gcagatgtga cgatcattga cttaaacgca 2609041 gaccgcttgc gccagcttga tgacatcttc ggccatcaga ttaaaacgtt aatttctaat 2609101 ccggtcaata ttgctgatgc tgtggcggaa gcggatctcc tcatttgcgc ggtattaatt 2609161 ccgggtgcta aagctccgac tcttgtcact gaggaaatgg taaaacaaat gaaacccggt 2609221 tcagttattg ttgatgtagc gatcgaccaa ggcggcatcg tcgaaactgt cgaccatatc 2609281 acaacacatg atcagccaac atatgaaaaa cacggggttg tgcattatgc tgtagcgaac 2609341 atgccaggcg cagtccctcg tacatcaaca atcgccctga ctaacgttac tgttccatac 2609401 gcgctgcaaa tcgcgaacaa aggggcagta aaagcgctcg cagacaatac ggcactgaga 2609461 gcgggtttaa acaccgcaaa cggacacgtg acctatgaag ctgtagcaag agatctaggc 2609521 tatgagtatg ttcctgccga gaaagcttta caggatgaat catctgtggc gggtgcttaa 2609581 ttcacaataa gcttgcagaa agatttctgc aggctttttt attttttaaa aggaaaaaag 2609641 agaccatttc acgaattatg actatgaagt tgatcataaa ggaggattca tatggctgtt 2609701 cagcaatatg gcgtgttaaa aggcatagta ttagacatga agcgggaaac agatgatgac 2609761 agtcctcatt tccaagtcaa aatgctcggt gaagagaata cgtattacag gtgcgccatc 2609821 aatgtgatgt ccagttctga ggaatctgaa gtattgtatt tggctgacga tcagtttgat 2609881 tcgggctcaa ttaccatcct tccgaacatg ccgtatggat atacaaggat caatgaagca 2609941 aaccgtgaag tggcactgga ttatgtgcgg ggcaatttgt ttgacccgcg ggaaatgaag 2610001 cctttgcctc atgaaatcac gggacctgat aatgatttaa atgattttat tgaaacctat 2610061 atgaagaaag cacaagatga gaaaacgccg gtttatatat tcggttcaaa attcggccct 2610121 gaacaggctg cagataaaat attcggcttt accccgacta acggaatgca caatatccat 2610181 atgaatcaag ggaatgcaat ggatacccgc tggaaaaaag acaacggctc ttggcatgac 2610241 gggggtattc tgattcagtt tgcagatcag tgggccgctg tgtttttagc gtttttatcc 2610301 caatcttggt gtaccgatga aaacggaaac cctgtcagag attgtgatca tacccaaacg 2610361 tctgcgtaag atagaaaaag agactgcggc aagcagtctc tttttgataa gattacacat 2610421 tttcaacagt ctttaggctg tttggcctca tatcgctcca atgcgattgg atatagtcca 2610481 aacaagcttc acgccctttt tgctcatgaa cgactgtcca gccgctcggc acatctataa 2610541 aacccggcca tagggaatat tggccttctt cattgaccag caccaaatat gtgccatccg 2610601 cattttcaaa aggatttgcc attctatttc tcctccctta tttattcaac tcttccaatt 2610661 tgacagcgag aaccttgccg atttgagcca gaggttcagg ctgacataaa tctttatgac 2610721 ggcagtcgat gtcgatttgt tcaatctgtc cgttaatata aggcttccac gagtcaggtt 2610781 caatcgggtc aaaccattca ggaatgattg ttgatctgaa aaacaaaaca tttccgcgga 2610841 aggttttcgg cttataggaa cctaaaatgc cgacagaatt tacatacgta ttcttcaaat 2610901 ttaaaatgac cgtttcatcc aggctcgcaa gcgcactgcc gtcacggcga agaatctcaa 2610961 tcgccgcttc aaaatctagc ggtttttccc ctaagctgtc tggatcatac ccgcctaacg 2611021 ccagaagggc aataagcgct tcctcatcat ccggtgcctc ttttatagga aggaagtggt 2611081 tcggataggc gtccagcatc accaacaggg atacttcttc tccttgattt tgcagctggg 2611141 tagccatcgc ttgaacgaca ttcccgccca gggaccagcc cagcagatgg tacgggcctt 2611201 ttggctggac cgttcggatt tgtttaatgt aatcggcagc catgtcatca agtgttttcg 2611261 gaagctcctc gcgctgcccg attccccgtg cctgcaagcc gtagatcgga taatctgttc 2611321 ctatattggt catcaaaccg gcataacacc agctgagccc ccctgccgga tgaacacaga 2611381 ataaaggagg cttgtctccg cttgttcgga gcggcagcag aacgtcaaga gcgctttggc 2611441 ttgatcccat ttcaagtctt tcagcgagcc cggctacagt aggtgcttcg aacaagttgc 2611501 cgatgctgag ttcaacgccg agcgcttcac gaatgcggct catgagctgt acagcaagca 2611561 aggaatgtcc gcctaaatca aagaaacggt catcaatgcc gacacgcggc aagtgaagca 2611621 cctccataaa gaggtcacag agaatttctt cctgcggcgt tctcggtcct cgtcctgtca 2611681 ctgccgctgc gaaatccgga gcgggcagcg ctttacgatc aagctttcca ttcggtgtca 2611741 gcggcaattc tttcatcgtc acaaaggcag caggcaccat gtaatccggc agtctctcag 2611801 cagcatatct gcgcagttcc gccgtatcaa atgtttcttc cgaagggatg acataagctg 2611861 ctaaccgttt atctcccggc tgatcctcac gaacgatcac tgccgcatct tcaagctgcg 2611921 gatgctgaac aagcgcggct tcaatttctc ccaattcaat ccggaatccc cgaattttca 2611981 cttgatggtc tgcacggccg acatagtcga gagaaccgtc agcgcggagg cgggccacat 2612041 ccccagtgcg gtacatccgg gtgcctggag gaccgaacgg atcagctatg aagcgttcag 2612101 atgttaaacc aggccggcct agataacctc gtgctaaccc cgctcctgat acatacagct 2612161 ctccggcaac acccggcggg accggctgca ggcgttcatc cagcacgtat acaccaagat 2612221 cgggaatgcc gcagccgatc aagctgtttg cccgtaaagc tgccatgctt cggtctaatt 2612281 cgatatagct cacatgcacc gtcgtttctg taataccata catattgata agctgcggtc 2612341 tattttcagg gtggcggttg taccaatcct ctaaacggct gagttcaagc gcttctccgc 2612401 caaaaatgac atagcgcaga ctgagtgcct gtccgagatc cggctgttcc cgttccgcct 2612461 gcataaactg atagaaagca gacggtgtct ggttcagaac agtcaccccc tctttgacaa 2612521 gcaggcgcag aaacgcttct ggcgatctgc tgacgtggtg aggcacgatt acaagacgtc 2612581 cgccatgcag cagaggaccc cagatctccc acaccgaaaa atcaaacgca taggaatgga 2612641 acatggtcca gatatcacct gagctgaaac ggaaccagtg ctcggtcgct gcaaataaac 2612701 gtgttacatt ttggtgagga atcatcacac cttttggaac acctgttgag ccggatgtat 2612761 aaatgacata tgccgtattc aaaggggaaa gcggctgagt cctatcctta ttttttggat 2612821 tacctgcagg gtacgtgttt agtttctctg ccagctcggg atcatccagc acgattttcg 2612881 gcacgttttc aactggcgga atgtgatttg cagctttagt gttcgtcatg ataaacgcag 2612941 gctgtgcatc ttttagcata aaagcaattc gatcagccgg ataatccgga tcaagaggga 2613001 gataagctgc cccggccttt agcaccgcca ataggccgac agccatttcc aacgatcggg 2613061 gcagtgccaa tgccacaaat tgctccggcc cgacaccttc actaatcatc attcgggcaa 2613121 gccggtttgc tctttcattc agctctgcat agctcagttc ctgattttca tatacaacgg 2613181 caatggcatc aggacgtaaa gcagcctgct tctcaaattg ctctggcaaa catgcgtgcg 2613241 gaatcttttc agatacactt tgccaatcag tcaccatgct gctgtgttcc tctggcgcaa 2613301 gaatatccag atttccgatt tgctcgtcag gatcagactc ggcagcctcc aacaggcgca 2613361 tcaatcggtc agcaagagcc tgagcagttt cccgtttgaa aagatcagtg ctgtattcaa 2613421 gcagtccttc cattccgttt ggtgtcccgt cagcaaggcg atcttcacta atttccagcg 2613481 tcaaatcaaa cttggcagaa ccgacactgt tgattcgcag gctgctctcc atatcaggaa 2613541 gatgcagttc agcgtccggt gtgttttgga acgcaagcat gatttggaat aaaggatgcg 2613601 tcgcacgcga acgagccgga ttgagcacct ctacaagtct ctcaaacggc agatcctgat 2613661 tgtcataggc ggccagattc acttcccgta ctctgtctag aagctcacga aagcttgggt 2613721 caccggacgt atcagttctg agcaccaatg tattaatgaa cagccctaca agatcgccca 2613781 gcgcatcatc attccgtccc gcgatcggac tgccgatcgg aatgtcggtg cccgccccga 2613841 gccttgtcaa taaagcggcg agaccggatt gaagcaccat aaacaggctc accctatttg 2613901 cgcgagccag ctcctgcaat cgcttgtgaa actcgggctc aatacgaaaa tgaatcgtat 2613961 ctccatcatg actcggctca gccggacgtg aataatcggt tggcagttca agctgatcag 2614021 gcaggttttt caaggtttct ttccagaaag caagctgtcc ggcaatcaag ctatttggat 2614081 catcctcgtt tccaagcagt tcttgctgcc aaagcgcata gtctgcatac tgcacagcaa 2614141 gaggcgccca ttcgggagat cgtccgtggc agcgagccgc ataagctgtc ccaaggtctc 2614201 tggtcagcgg tgttaaggac cagccgtccc cgacaatatg atggacgaga agaagcagca 2614261 cgtactcgtc aggaccgatc acaaaaagct cggcacgaaa agcaggttca gctgcaagat 2614321 caaagctgta gcgtacagct tcggcaagcc gatcagaaag ctccttctca gcaatttcag 2614381 taacatgtaa ctcgggacag gctcgatcgg catctaaaat atgctgatag gatgtcccct 2614441 gtgattcagg gaagatcgtc cgaagacttt catgacggca gacgaggtca taaagtgccg 2614501 ctttcagcaa tccttgatcc aactcacctg acaaacggac agcaaccgga atattataag 2614561 taggactcgg tccttccaga caatgcagga accatagccg gcgctgggca aatgagagcg 2614621 ggatcttttc aggccgctca gctctctgca aagcgggaca tgcactctgc gccaaatcaa 2614681 gatgggcagc gagtccggct actgtcggtt cgtcaaagag cttggcgata ccaagttcgg 2614741 ctcccattac ctcgcgaatg cggctcatca gacgggctgc aagaagagaa tggcccccaa 2614801 gctcgaagaa actgtcatcg ataccgacgc gtgccaaacc gagaacctct gcaaacaagt 2614861 cacacaatat ctcttcctga ggagtccgcg gggcccgatc actgacagat gtgctgaagt 2614921 ctggtgccgg cagtgctttc cggtcaagct tgccattagg tgttaacggc agctcgtcca 2614981 tctccacaaa cgccgacggt accatataat caggaagact agcccccata taacgacgaa 2615041 gctctgcagt atcaatagca gcatcagcga ctacataagc cgccaatcgt ttgtctcccg 2615101 gctgatcttc ccgtacgaca accgcggcct gttcaatgtg cgggtgattg gcaagcacgg 2615161 catcaatttc tccaagttca attcggaatc cgcgaatttt gatttgatga tccgcccgcc 2615221 cgatataatc caaagaccca tcggcgcgcc agcgggcctg gtctccggtc cgatacatcc 2615281 gagttcccgg cggtccgtat ggatctgcaa cgaagcgctc cgccgttaaa tcaggacgat 2615341 ggaaataacc tctggccaag ccggttcctg caatataaag ctctccgaca acgcccggcg 2615401 gcaccggctg caatccatta tcaagcacat acacctgcgt gttccaaatc ggtttcccaa 2615461 tcggaggaac gcccttcagc ccttcttcaa gaaaagctgc ggcagaccaa atcgttgttt 2615521 cagtgggacc gtataagttc gtgactgaac aatgaaggtc ttgaagttcc tgcaaaagac 2615581 cgctcggcag cgcctcgcct cctacaagca ctctaagccc ccgaagtttc tcaggttcac 2615641 tcgttaccaa agcgtgccac agtgtcggtg tcgcctgcat aatgttaata tcgaaatttt 2615701 caatcatttg agctaatgcc tgcggctcac ggatcgtttc tttctttgcg atcacgattt 2615761 gcgctccgct aatcagcgga agatataact ccaatgctga aatatcaaaa gcgacagtcg 2615821 tcacagccaa cagcctgtct tcttctccta gagaaaatgc ctcctgcata gacagcagaa 2615881 aattgcttaa gcttttctgt gtcacaacga ctcccttcgg tcttcctgtt gatcctgagg 2615941 tatagatgat atacgcagga tggtcaagcg aaaccgatac atcctgattt tccggcgaat 2616001 agcgttttat aatctcctgt gtaacagcct gatcaagcac aagctcaggt acagccaggt 2616061 catcaggcag actggctgct atttcctcag tcgttatgat gcatgaaggt ttcgcatcct 2616121 ccagcatgta agaaatgcgg tcggctggaa actccggatc aagggggaga tacgccgcac 2616181 cagtcttgag cacaccaagc attgaagcca ccatctcagg ggaacgcggc agcgccaaag 2616241 cgacaaattg ctccggacca atcccttttt cgatcaacag acgcgcgagg cggtttgcct 2616301 cttcattgag ctttcgatag ttgacttgaa tgtcatcaca catgagagcg atacgttctg 2616361 gcgtaagaac tgcctgcttt tcgaacatgt cctgaaggct gaccagcttc tcggattttg 2616421 ccgtctcatt ccatttagaa atgacttttt ctttctcctc tggcaacaga agctccattt 2616481 gcccaatcag catgtcctct ccggcagaag ccgtttgcag cagctgcaaa atacgctgct 2616541 gatgaagctt aatatcagac tcactgtata cctcgggatt cgcatcaaca tcaattcgca 2616601 gcccgctgcc gtctgttctg tcatatacat tgattgatag atcatcaaca ggaccggctg 2616661 aaagattatg cgttgtgccc cggacgccgg caaagtcgag accgtaatca aacggcataa 2616721 gattgatttg agggccaaat aatctatgat tttctcctat caatttcaga tcgcgcctaa 2616781 gctcttcatg gcgatactta tgatgtcgcc gaatactgcg gatttcccgg gaaatttgct 2616841 gaatcagttc agaaaagctc atcgaagagc ttaccgtcag ccggagcggg agaaggttca 2616901 tcaccatagc cggtacattc agtgacgcgg accctatccg acccatcatg ggcaggccga 2616961 gcacaacatc ctcagagccg gtcatacggt gcacataaac agctgacacc gcaatcatga 2617021 cttcatgcca gcttcctgag aaatagcgcg ccgcttcttt taacgcgttt acatcagacg 2617081 gaggcagata tgccgtatga cgaagaaaac tgttagatgt tcttggcgcc cgatcagcca 2617141 agctcacaac ttcaggtgca tctgcaaaac ggtccagcca gaattgacga tccttctcat 2617201 actgctctga tccgcgataa tctgtatcct cctccaaaat ggcctggaga gacccaaagg 2617261 aacggctttt agctgtttgt ccttttataa gggcagtata tgtacttgcc acacgctggg 2617321 ctatcaggga aaaaccgaag ccgtcgatcg ctatatggtg aatgcgctga taccaaaaga 2617381 aacgatcagg cccggcaata aacagagctt cattgaacaa aggggcatac cctaaatcaa 2617441 ccggctttgc taaatcagct ttcatccagt ttaatgctgt tttttccgga tcaggctcag 2617501 agctgacgtc aatgacgtgc agctgtacat ccggagacgg gtttatcatc tgccaaggcc 2617561 cgtccatatt ttcaccgaag cggacatgca gcgattccgc ttccttgatc acgtgccgca 2617621 aagcttcttc aaaaagagca atattgactg gtccattgat ttctatatat tccgctgtat 2617681 tgtagattgg attgtccgga tcaagctgct gagcaaacca tatgccagtt tgcgccccgg 2617741 tcaaagaata ttgaagatct tttgtatcag gcatccgttt gtttaccctc cttttataaa 2617801 taatccgcgt ttggcagcac ttgctggctg cgagttgtga gcaatttctg ccattcttcg 2617861 atcgttgggc gttcagccaa ttccacgaaa gtcacctctg ccccttcacg gcgccattgt 2617921 tccaccaatg tcatgatcct taccgaatca agaccacgat cgagcaaatc ctcttgatct 2617981 gtgatgtctt ccggtgtttc ttgtagaagc tcagcaattt gtttacggat attctcacat 2618041 gtaaacacgt tctttttgcc agtgtttgct gacgtttttt gaacgtctgc cggcgcattc 2618101 tgcagctgat caagaagact gtcagtcatc acggtaaacg cacagcgtcc agccgcatat 2618161 tccagcgcca tttgatgttt ttctaatgaa aaatcagcaa ctgcatctcc cacaaaaaag 2618221 gctttaatat cctccataaa tgcttcacat gctgtaacaa gacagccgat atgggcgtaa 2618281 attcctgtaa tgatcagctg atcgcgtccc tctttgcgca tcatttcaag cagattcgtt 2618341 ctcttaaacg cgctgtatct ccattttgtc agcacaagat catcatcctc tggtgccagc 2618401 tcggttataa ttttctcctc ataaggaccg ctgtttaatc ccgggcccca aaagtctgtc 2618461 agcagcgcac ggtcatccgg attttggctt cccggctgtg cggtatagac aacaggaatc 2618521 ccaagctgaa cacattgatt cttcagcttt cgtatattcg ctgaaagctc tgttaccgga 2618581 gacgctcccg ctgtgaaagc atcaacaaaa tagttttgca tatcgtgtat taacaagaca 2618641 gcccgattcg gatcaggcac ccatgatact ttgttttgcg gcatatcaga tgctgtcggc 2618701 atttgatacg gctgaatggc aggtatagcc atatgaacac ttcctctcaa attgttgttt 2618761 tattttttaa atcctgcaag aagcttctcg gaaatggctt cacggagcgc ttttttgctg 2618821 acttttccta ctcctgtctg cgggaaggat tcgacaaatt caactcgatc agggatttta 2618881 tatgccgcca gtccgcgctc tctcaaaaat gctttaagct ctgcggcttt tggggcttca 2618941 tcccggggaa taatgaacac acaagatctt tcgccaagaa attgatcagg catggagacc 2619001 attgccgcat catggacagc cggatgcgcc agcagatgat tttctacctc ttcagccgca 2619061 accttttctc ctccacggtt aatttgatcc ttcgcccggc cttcaacgac aatatagccg 2619121 tctcgtgtca gcctgacgat atcacccgta cggtaaaaac cgtcctcagt aaatgaagcg 2619181 gcgttatgct cttctgcctt atagtaacct cgaattgtat acggcccccg cgtcagcaga 2619241 tggcctgttt caccaggttt tacgtcgcga tcatgatcat cccaaacacg catttcatca 2619301 tatggagaca tcggttttcc ttgggtgttg acaatgatct cctcaggatc atccaatctc 2619361 gtataattga cgagaccctc tgccattccg aacacctgct gcagcgtgca gccgaaaaca 2619421 gcttttaccc tgcgcgcggc ttcagcacta aacttggcac cgccgacctg cagcacttga 2619481 aggctggata aatcatcacg gcgtgaggat gccgcatcca tccataccat cgcaagaggc 2619541 ggaacaagag cggttatcgt gaccttttcc cgttcaatta aaggaaatgc gtcatctgga 2619601 cttggagaag gagataatac cactcttcct ccagcgtata atacgccgag aacgccgggt 2619661 gagctcagcg gataattgtg tgccatcggc agcgcggcca agtacaccgt gctgtggtcg 2619721 agccagcaga cctccacact ccgcttcagg ctgtatatgt agtcatcgtg ggtcctcgga 2619781 atcagtttcg atagcccggt gctcccgcca gaaagctgga ggaacgccac atccgatgat 2619841 ttgacttcag gcagttttac aggttctgca tgcaaatcct ccagcggtaa aaattcctct 2619901 gcctcacctg cgacaatgat gtttttcaaa gtcggcagct tgctttgaac ctgtctggca 2619961 agcgaacggt agtcaaaacc ggaataagcg tcgggaatga tatatgcagc cgcttcagca 2620021 aactcgcaaa aatatgtaat ttcactgctt cgatgagaag gcagtgcgaa gactggaagc 2620081 gcccccagac ggaaaagcgc gaaaatgact tcaaaaaact ctttgatatt tggcaactgc 2620141 accacaacac gatccatctg ttgaatgccg agcttttgaa atccggcagc caggcgatca 2620201 gcccttgtgt caagctctcg atagctccaa tgggtgtttc cgcatgtaat ggcaatgcga 2620261 tcaccatatt tggctgcccg gtcccttaac aaatctccaa acgtctcacc ggcccagcag 2620321 ccgttctttc gataggtctc agctaactca tcaggccaag gcgtaaatcc tttcagcatg 2620381 ttgtatccct ccagcaattc attctgttca tatgtgatcc acgcccattg cccgcagcat 2620441 tgtccgaaac tttgcggacg tctcctgaag ctcgtcctca ggctttgaac cggccacaac 2620501 accagctcca gcatacaggc ggagtgagcg ttcttctgct tctgcacaac ggatggtcac 2620561 gatccattct ccgtcaccgg catcgtcaca ccatccgacc atgccggtaa agaaaccgcg 2620621 gtcaaatggt tcaatgctga gaatcgcttc tcttgcaaga tcagtcggtg ttccgcagac 2620681 ggctggcgtc gggtggagcg ccgccgccaa ttcaagtgcg gttacagacg ggtcggaaag 2620741 ctctccctta atcacgctgg acaggtgcca catcgtttcc gttttgatca gtgaaggctt 2620801 ctccggaacc tccagcgtcc ggcagaaagg tctcagcgct gccgcaaccg cgtcagcgac 2620861 aaccgcgtgc tcatgaagat cctttgcgga agaaagcaat tcagctgccc ggcgctggtc 2620921 ttcaacagga tcattactgc gcggtcttga gccggctaat gggttggaaa cgacctgtgt 2620981 tcccatcctt gaaacgagaa gctccggact tgctccgagc aatgttctgc ggggagacgt 2621041 ttcctcctga ctggacacgt ctgcggcaaa cgtgtagcca tgcgagttat gctgagccag 2621101 atggcgaagc aattcatccg tctgaatcgg ttcaggcgat gtcaaatgca gcgatctgga 2621161 caggacgatt ttgctgagtg ttccatcggc aatgcgtgcc agcccttgtt caacaccatt 2621221 tttataatcc tcaggttcag gaacaggctt tatgtggtat gtatgcccag cctgctgttc 2621281 cttttcctca tgatcaaatt gaagcggtcc tgaccagcgc acttcttcag gtacaacgag 2621341 ccgcgctgct tttacttgat caaaaggaac ggccccgaca acaagcggcc ggctttgccc 2621401 tgattgtttt gcctgacgta acgcctctgc aattcggcca gaaagggttt ccatttggtt 2621461 ttgcccgtct gcctccggta caatttcaca tatgcctttc gctaacagta cacgatgagg 2621521 agacgctaag aaaaaggcgc ccggctgata ttcatgaagc aaatgctccg cttttgtttc 2621581 tgttataacg ttttgatcca acattctcat gaacctcctt taaattcagt tacacgccta 2621641 aggtcgcgcc gccatctacg cataaattat gcatcgtaat atgccctgcc tggccagaaa 2621701 ccaaaaagag caccgcatcc gcaatatccg aaggcttggc tagttttttg agcgggatcc 2621761 ctgttttaaa tgtctcaagt gatcctttta tgacttgctc cgctccattc tcgtcggccc 2621821 ataatgacca ctgcatgtct gtttccgttg atccgggaga tacaatgttg cagcgaatat 2621881 tgtattctgc aagctcaagg ccaaggcatt tcgtaaacat cacagccgca gcctttgaag 2621941 acgcatatgc cgccatagat gttcttggta caccggcagc attcgatccg actgttacaa 2622001 tcgaacccga tcttcggtcc atcatatatt tgctgactga acgcgaggcg ttaaatacgc 2622061 cagtcgaatt cactgagaac gtcgcctccc attcctcatc gctaagcgaa tggatcagtc 2622121 ccgggcgaag gacacccgct acattcacta aaatatcaat cggccccatt tcacgttcga 2622181 tgcgcgccgt gatctcgtca atcgccgcgc tgtctctcac atccgcagga aaagcttctg 2622241 catggcggcc ttctgctttg aggctgctca caaccttttc cagcttttca ggattataat 2622301 caactgccgc aatatgtgcg ccttgactgg caagcgtccg cgcaacagct tcgcctattc 2622361 cttgggcagc ccctgttata aaagcaattt ttccctctat accctttgca ttcatatcat 2622421 caattccttt cttcgctcta aatgccaaac agacatccag cgaaaaagac tgctgcgcct 2622481 tgaaaaacgc aatctattga taatgattat cattatcaat tataaaaata atcatatcca 2622541 aatgtcatgt gacagtcaaa tataatttca gtgacaaata tttttttaaa ggcaaggctg 2622601 agtatgtctc agcccattga tagatgcggt ccgtcagggt gaagcgcaaa acgcagcgcc 2622661 ctgctgacca aaacaggaag aactgaaata tgtccttctc ctgaaaactc gcaaaattct 2622721 gcccgtatac cttgttcaga taaaacggcc agccgctcat aaagctccct tgcattatca 2622781 ttcatccggc ttttatgatg ctgctctaat tctcctgcgg caagcaggat attgataggc 2622841 tgattgtttt tcttggtgag agagacgaaa tggtccgttt tcttgagaat aaacggttta 2622901 ttccaatgaa tggacggact tcccgcgata tacgtttgaa acgcatcggg ctttgttagc 2622961 agcacctgca gcacgaaaag ccctccgagc gaatggccaa agattgtttg tcttttttta 2623021 tcaatctggt aatctcgttc tatctccggt tttaaatcct cttcaataaa tctgaaaaag 2623081 ccctccgctc cgccatgctc cggccattct ctgccgtcgg gcctttccgg cagcttcgat 2623141 tgggctgttg gcattgtaaa atcccggtgg cgtgctgagg agaacggctc cgctgtctca 2623201 tagccaatgc cgacgatcac tgcagggatc accccggttt tttcgggtcg gcgtccctgt 2623261 attcgaacgg cttccgtcat cgttccgaag acagaattgg catccagcag ataaatcaca 2623321 ggataaccag cgggtggcgg cggcgtacta ggtttcgaga taaaaatgtg ataggtacgg 2623381 ttttcattgc gtgaagacat catacgcact tccgtaccag gaatcgtaaa tgcgtttgat 2623441 gtcccgccat ttgtccggtc tgttgtttgt tctttcatgc agtacgacat tcctctcctt 2623501 aaactaaacc gcaatgtatg ataatgattt tcactatcaa ctagacacct caaataatag 2623561 gttttcttcc aaagaaagtc aactttttcc cgaataaaaa aggcaccttg atcaaataag 2623621 gtacctgcag actatcaata tggaagtaaa aacctaataa agatgcgtat tgtcctattt 2623681 gaaatagaac cttaatccca tgtaaacctt tgattttgcc aagggtcgcc tctcatgtga 2623741 tagccattcc gctcccaaaa gccagggtga ttttctttcg taaattggat gccgcgcagc 2623801 cacttggcgc ttttccaaaa atacagatgc ggaaatacac cccgcagcgg aaagccgtgt 2623861 tcaggggtta aaggttcgcc attatgcgca taagccagaa gggaagtttc cgctaagaaa 2623921 tcatcaagcg gcagattggt cgtccagccc tcttcagcat gtaaaatgac gtagcccgct 2623981 tcttctttta cacccgcttt ttccgctata tcacaagccc gcacgccttg ccacacatta 2624041 tcaagccttg accatcccgt gacgcaatga atgtcgtttt tcgattcata ccgtggaaag 2624101 gctttgacat cttcaaagct tagcagcatc ggatggtcaa ccaaaccgta tacttgaaga 2624161 ttccatttcg tcatatcttc gtaatatggg acatctccgg tatgaagcac aggaaatgaa 2624221 gtggtgacgt tttgatttgg cggcactctt ccagattgat cggactgtct tgtttttccg 2624281 aaatacatat gggcctcctt tttgttaacc taatttaaaa tcatgttgac aatctttttg 2624341 ttctttatta ctctatgatt gtgtatgtca acctaagggg gaacaacgat gaaacaacgt 2624401 aaacttcgtg cgggagatat ggcgctgatt ggcatgttcg ccgcacttat ggctgtcggg 2624461 gccaacatta catcagtagc acccttttta caagtagccg gcattccgct ttcgatgcag 2624521 ccgtttttct gtctcttggc agctttgctt cttggcagca aacgggcagc gattgccatg 2624581 attgtatatg cacttgtggg attggccgga gcgcctgtgt ttgctcaatt ttcagcaggc 2624641 ttcgcaccgt ttgcagggaa aagcggcggg tttattatct catacattcc ggcagcattt 2624701 gcagcgggat ggtttttaga acgaaacatt cagccaagta aaattcgatt tctcattgct 2624761 tcacttatcg gaacggcgat catgtatctc atcggcacta cctatatgta tcttgcactg 2624821 aagctgtgga ttcatacgcc agtgagctac ggcacggctt ggggctttat gatttggttt 2624881 atggtaaaag atacagcgct ggctgtgata ctgtcgttta tcgcaccagc aatctaccgc 2624941 tctattcata aagcaaccgg ctttaacaga aatcacatat catctacgta aaaaccgttc 2625001 tattggacgg tttttttatc ataacgagaa aaggctcccc agtaaagggg agcctttttc 2625061 ctataaaaca agcgctgcaa tccagccaaa gatgacaagc ggaatattat aaaatataaa 2625121 tgtcggcaca caagtatccc aaatgtggtg atgctggccg tccgcactca aacctgaagt 2625181 cggcccaagc gtactgtcac tggcaggtga accggcatcg ccaagcgcag cagcagcccc 2625241 gataatcgca atcgttgcca tcgggctgaa tccaagctgc atgcatagag gcacgaaaat 2625301 ggttgtgata acaggaatgg tcgcaaaaga agatccgatc cccattgtaa ttaataagcc 2625361 gacaatgagc atcagcaatg cgcccaagga ctgactgtgt ccgataaaac cagctgacgt 2625421 tttgaccagt gactcgacat ctccggtttt cgtcaatacg tttgaaaatc cggctgcaac 2625481 aagcatgaca aagccgataa aggccattaa aaccattcca tcagtaatca gtgagtccgc 2625541 ttcatcacgc ttcatcacac cgctgacaaa cagaacaatc agaccagcga gcgcccccat 2625601 aatcattcct tctactccca aagtctgaga taagtaaagc tggacgccga gtgacacaac 2625661 aatggctaga accgcgatac caatactttt tctcgtatat ggcgatgctt ctgcacctga 2625721 aatgtctttt gtttcatatt gtttcggttt acggtatacg atcactgata aaataaggcc 2625781 gacaaccata cctgcaactg gaataatcag tgcgtacgga atatcagcaa gcggaacgtt 2625841 taacccggca tccgccatat tgtccttcag catgccttgg aagatttggc cgaaaccgac 2625901 cggaagcaaa atataaggag ccgttaagcc aaatgtaatt acacacgcga tcagacggcg 2625961 gtccatttca agttcattaa agattttcaa aagcggcgga atcagcaccg ggataaacgc 2626021 gatgtgaacc ggaacgacgt tttgcgaaaa acaagataca attaaaataa tcagcacaat 2626081 cagcacctta gacagtgctt tttttcgaga atcttcttta tttccgatta atttaacgga 2626141 ggcttccacc attgcgtccg gaagacccgt tttcgtcaaa gcggcggcaa acgcgccaag 2626201 catggcatag ctaactgcaa cggtggcatt tccgccgaga ccgtctgtga aagctttaac 2626261 cgtttcgcca agaccgagcc cgcctgttaa cccgccggcc aaggcgccta taattaatgc 2626321 gataacaata ttgacacgca gcaggcttaa tacaagcata agcaggactg cgatgacgac 2626381 tgcattcatg atgatacccc tccaaaaatc ctttagtttg ctaatgtagt agataaataa 2626441 agtacgaacg tatcgtatca taaccgatcc actttagtca actaaagatt tcggaagaaa 2626501 aaatccctgc cgcatcatac agcagggatt tttcattact cgtttttatc ttcttccaat 2626561 gtaaatcgct ccgcaagtgt agccagtgtt cttgccataa cgccagtagc cccggccggt 2626621 ccgaagcagg ttgctttatt ggcagtcgct gtgcctgcaa tatcaaggtg aacccaaggt 2626681 gttgactcag cgaattcacc aagaaacgtt cctgccataa tcgcatgtcc ctcgcgtccc 2626741 ggtgaattgc tgagatccgc catttggctg cttttcacgc gttttttatc cttctctgtt 2626801 atcggcagct gccagatcgc ctcgccgcac tcttgtgcag catcagctac ctgctggtaa 2626861 aagctttgat catttgtcat tgcaccggtt gtttctgttc ctaatgccac aacgacgccg 2626921 ccggtaagcg tagctacatc gacaagaact gatgcgccat gctgtttcgc gtatgtaatg 2626981 ccatctgcaa gcactagcct tccttcagca tccgtattaa ggatttctat tgtttttccg 2627041 cttaaagata cgatcacgtc atccggcttc atggccccgc cggagatcat attatcggtt 2627101 gatggaataa cgcacagcac gttttgttca ggacgaagct ctccgatcgt ttccatagcc 2627161 ccgagaaccg cagctgctcc tcccatatct gatttcatgc caacaattcc agatttcgtt 2627221 ttaatggagt agccgcctgt gtcaaaggta attcctttcc cgactagtcc gacgacgtct 2627281 tcccattcct ttttgccctg atatttcaac acaatcattt tcggcggttc ggtggagcct 2627341 tggtttaccg caagtattcc gcccataccg agctcttcca tctctgattt ctccaatatc 2627401 tcacactcaa aatcatattt cgccgcaagc tcttcagcat acgaagcgag gtcagtcgct 2627461 gtcagcatgt ttcccggcat attcacaagc gttctagccg aatttgtccc ttgtccgtat 2627521 gcctggccga cgcgaagccc tgcctgcact tcctgtgtat cttcatctgt tacaacatac 2627581 acggcttcaa tttgtttgtc aggctcattt gatttatgct tataatcctg cacctcatag 2627641 gaagcaagca ggcagctctc agctaaagca tgagcggcat cggctggagg cacgtcttcc 2627701 gaaataaacg tatcaagcag aacagcagtt tcttgttttc gatctttatg aatggcttga 2627761 aaaacatgag caaaacgttc cttcgcctgt tcaaacgaat aatttgcttc tctccccagg 2627821 ccaacgaaat aaatccgttt catacccgca gaagatggag ggaatacttt tgatacttga 2627881 ttcggtttcg cagagacatc accctctttt aaaagctgtg tcagatggcc ttcgagcatt 2627941 tcatcaattt ccaacgcttt tcctgtcagc tggctttttt gaaaaagccc gacaacaagg 2628001 gtttctgtat gctctgattg ttgaaccgca taaaacatga ggcttacact cctaacgtaa 2628061 tgggtatttg taatgaacaa tggtataata ggaaaaacat tctttccact atacttattt 2628121 taacaaacaa cagtctaaga cttgcttttt tcttttgaaa cacgaaggat ttttcaaata 2628181 gaaaggatgt cgccgatgga acttttaacg aattttcctt tattatcaag cctggccgca 2628241 attatttttg ctcaggtcat caaagtgccc atacagttta tcgtgtccag aaaactggac 2628301 tggtcgctgg tcacaagcac aggcggcatg cctagctctc actccgcagc ggtcactgcg 2628361 ctttctacag gcgtagcctt ggagcatgga ttagactcct cactctttgc ggtttccgcc 2628421 attttcgccg tcataaccat gtttgacgca actggcgtca gacgtcacgc cggtgagcag 2628481 gcaacagtca ttaataagct tgttattgat tttaaccgtt tcgtaaatga agcgaaggac 2628541 ttccctaagg ctgcagagaa agaaaagcaa aaaaagctga aagagcttct cggacatcag 2628601 ccgatcgaag tctttttcgg aggattaaca ggtattttac tgacattggt actcgcttac 2628661 tttttcatgt aaaaaaaacg ctcctgcttt cgctggagcg ttttattctt tcaccgtttt 2628721 atattgattt ctgaacactt gcaaagattt tgtttcattg agcttctcaa gctcatcctc 2628781 ggtaatcttt cccgttccct ttttaatcac atatacatca agggtttttt tgccccattc 2628841 attgtataca tctttgactg tctcaaagta cagatcaagg cggtttccct taatagctga 2628901 tcctgtgtcg gccacaactc cgagaccgta gttcggaatg aataaaattg ttccgatcgg 2628961 gaaaacggac gggtcagcag caaccgtgga atataaatcc cgtttcactt tcacacctga 2629021 atatgtaagc ccgtataatg gatcaccggg atttttgccc gtcgactcag ctcctgctgt 2629081 gtagcctgtt gctgttactc tttggactgg atattcatcc caatcaaatg cctcttctaa 2629141 cggttttgtt ttatcctcag ccgcggacgt ggtttgtgtt tgtttctgct gcaatgcttt 2629201 taatctcagt cctgcatgct tcaagtgctt ttcctgatgt tcctgcaccc attttgacaa 2629261 gtccttcgct tcaattcctg acactgataa aaatgtcgtg ccaaatgcaa gcagaaataa 2629321 acaggtcatc agcaaacgtc tgatcatatt caacatcatt cacctctcct ccgaatcatt 2629381 gttcccaagt ggagagagca ttattcaaaa tggtgaatga gctgaacgca taaaaaaagc 2629441 tttctttaga agaaagcggc atttaaaaca tttgatatcc tctttttcta agcatgttga 2629501 tcgctatacc ggacacgatg gcgccggcca aaccgctgac taaaatcagc acatcagcag 2629561 ccgctaatga taagacacga tgaaacaggc tggcaaagga ttctcccggc gactggacat 2629621 agctgatcag cttttctttg ctgataatga aaaggcatac aattggataa atcacagcca 2629681 taatccaaga cattctcagc agcatgttta ataagaaacc gattccaaaa aacaagacaa 2629741 aaaacaaaac aattgagatg attacgactg gcagactaat caacctattc cacccccctg 2629801 cgttgttttt agtgtaacgc gggggctgaa ataaagtcaa cggctggaaa aagaatgact 2629861 gtcttttcct gtcccctggc aagacggaca agtctctgaa ccgccgagaa tcaattgaaa 2629921 atatcctttc cctgaacaaa atgggcatgc atgtgaagcg gttgtcgttg cagttttcat 2629981 ctaatcatca ccctttttct taattttctg ataatatacc atatcaagct gtcaacaata 2630041 aagtcagatc atgtgacaaa tcttttgatg taagcggaaa catacttgtt ttcctctcgt 2630101 tctcttttta ttttggcgtt ttttaataaa gaaaacccgc ttccgcgggt ttttagaaaa 2630161 acttgaactt gccttttttc aatgtcagtc cgagtccgcc aatcataaac agtgagcggt 2630221 tatcaatgac ttttttcata aacgaagcgg gcgtgccttt cagctttctg ccataaacaa 2630281 ccccaaccgc gttatgctcg ccaagagaag ccactgttcc cttaatgtcc ggcttgaatt 2630341 cctcaagctc tccgccttta ataagcctgc caaggttttt agcgaccgtt atgccctgct 2630401 gcattgcaat ttgcgcagtc ggcggatacg ggcgctctgt atcttcattc ataaacagcg 2630461 agctgtcgcc gagaataaag acattgtcat gtcccggggc gcggagatca gggttgactt 2630521 tgactcggcc gcgcatattc tcaaaaccgg cttcctccac aatcggatgg ccgcggacac 2630581 ctgccgccca tacaacggtt tgcgatttga tctgctctgg ttcttcatct tttttgccga 2630641 ctctgactcc ttctggtgta cattcttgta cagccgttcc gatcttgaac tcaactccgt 2630701 tttcctcaag ataatgtacg gcgtaatcaa caagttccgg atcaaagccc ggcaaaacgg 2630761 tcggcgctgc ttccacacaa atgatgcgga caaggcttct gtcaacgtca tattccttac 2630821 agagctccgg cacgcgagca gccagttcgc caagaaattc aattcccgta aatccggcac 2630881 cgccaacaac gatcgttaac ctgtccggcc gtttttccgc ttccgtattg taagtcgcaa 2630941 actgcagctc aatatgttcc cgcagcaggc gcgacgtgtt gatgttggca atcggaaacg 2631001 catattcttt taagccttta atgccgaacg tttcaggcac ggcgccgagc ccgatgacta 2631061 aataatcgta ctgcaattct ccattcgcaa gcacaacttt tttctcatca attttgattg 2631121 cctttacggt atcctgtaca aaattcaccc gtgactggtt gattacatct tttatctgat 2631181 aacggcagcg gtcatgatgg agcgtacccg cgctcgcttc atgcatccat gtcgtttcat 2631241 aatgataatt gtgtttattt acaagcgtaa tgtcagcatc attcggcccg acatacttcg 2631301 tcagccttgt caccgtcatc aatccgccat atcctgcacc taaaatcacg attttgggct 2631361 tattcaatgc catcacatcc accttctctt tttttgcttt tgttagaccc ataataaaat 2631421 catcatttgt gttagcttca gcttattggc gggattttat gaaatatatt gaaaagtttt 2631481 ttgtgaagtc cttacccgta gcactattat catgtttatc cggctggccc aagaaacatt 2631541 cagaaaaaga tcatttcatt tggttattat cgtagcggcc tgcggaaata ttttcaagaa 2631601 cggatgggca cgttagatcc ttacgatttt ttctgctgac tcgtcaattt gaacggcaat 2631661 atggtataat taataacaat tttcatttag gaggcaattt tcgtatgcga gaggatacaa 2631721 aggtttatga tattacaatt ataggcgggg gaccggtcgg cttattcacc gctttttacg 2631781 gcgggatgag acaggcaagc gtcaaaatta tcgaaagcct gcctcagctc ggcggacagc 2631841 ttagcgccct ataccctgag aagtatatat atgatgtagc gggattcccg aaaatccgcg 2631901 cgcaagagct tatcaataac ctaaaagagc aaatggcgaa attcgaccaa accatttgtc 2631961 tggagcaagc ggttgaatct gttgagaaac aagcggacgg cgtgtttaag cttgtaacaa 2632021 atgaagaaac ccactactct aaaacggtca tcataactgc aggaaacggc gcattcaaac 2632081 cgagaaagct ggaacttgaa aatgccgagc agtatgaagg caaaaacctc cattacttcg 2632141 ttgatgatct gcaaaaattc gccggcagac gcgttgcgat ccttggcggt ggagattccg 2632201 cggttgactg ggcgcttatg cttgagccaa tcgcaaaaga agtatcgatc attcaccgcc 2632261 gcgacaagtt ccgagcgcac gagcacagtg tggaaaacct tcatgcgtcg aaggttaatg 2632321 tcctgacacc attcgtccct gcggagctga tcggcgaaga caaaatcgaa cagctagtgc 2632381 ttgaagaagt gaaaggcgac cgcaaagaga ttttagaaat tgatgactta atcgtcaact 2632441 acggtttcgt ttcatctctt ggaccgatca aaaactgggg cctggacatc gagaaaaatt 2632501 ccattgtcgt gaaatcaaca atggaaacaa atatcgaagg cttctttgca gcaggtgaca 2632561 tttgtacata cgaaggaaaa gtcaacctga ttgccagcgg cttcggcgag gcaccgacag 2632621 cagtgaacaa cgccaaggct tacatggacc cgaaagcccg cgtacagcct cttcactcaa 2632681 caagtctttt tgaaaataaa taataaaaaa aggagcttgt gtctgcgaca cagctccttt 2632741 tttatttgaa gatatttata taattcaatg cagttcctac aaccagcgca atcacaaggg 2632801 ctgcgactac ccagatcatt gccataataa tgcggtcctg aatcttttgg gacttcggtg 2632861 ttttttcttc gttttgggcc atcttattcg ctcctttccc atgtccatgc cataaagaaa 2632921 gcctggtgct gaacgaccaa gctttgctga acgtatatca ttcgcgtttt gatccgctct 2632981 ctaagaccat tcgttaaaac tatgatacct aaactcaccc tgcatgacaa gcttcggcac 2633041 ttgcaccaca cctgccagca aatcataatg tttgacatcc taaataaaac agagtacatt 2633101 atataaggcg aacatttcat atattatact tttaaatatt cgtttttagg agtgaaaacc 2633161 atggaaaacg tatttgatta cgaagatatt cagctaattc ctgcaaaatg cattgtgaat 2633221 agccgttcag aatgtgatac atccgtacgt ttaggcggac atacatttaa attgcccgtc 2633281 gtccctgcca atatgcagac gattatagat gaaaaactag cgatttcatt agccgaaaat 2633341 ggctactttt atgtgatgca ccgatttgag cctgagacac gaattgattt tattaaagat 2633401 atgaacgcac gcgggttatt ctcttctatc agcgtgggcg tcaaagatga ggagtatgaa 2633461 tttgtccgcc agctggcaga agaaaatctg actcctgaat acgtgacaat tgacattgct 2633521 cacgggcact caaatgctgt cattgaaatg atccagcacc ttaaaaaaca tttgccggac 2633581 agctttgtta ttgctggcaa tgtcggaacg ccggaagcgg tcagagagct tgaaaatgcg 2633641 ggagcggatg ccactaaagt cggcatcgga ccgggaaaag tatgtattac gaaaatcaaa 2633701 acaggcttcg gcacaggcgg ctggcaatta gcagcgctgc gctggtgtgc caaggctgcc 2633761 agcaaaccga ttatcgcgga tggcggcatc cgcacccatg gcgacatcgc aaaatcaatc 2633821 cgattcggcg caacgatggt catgatcggt tcactatttg ccggacacga agaatcgcca 2633881 ggccaaacga tcgaaaaaga cggaaagctt tacaaggagt acttcggctc agcctctgaa 2633941 ttccaaaaag gcgaaaagaa aaatgtcgaa ggcaaaaaaa tgcacgtggc gcataaaggc 2634001 tcaatcaagg atacactgat tgaaatggag caggatcttc aatcttctat ttcttatgca 2634061 ggcggaacaa agcttaacgc catccgcaat gtggattatg tgattgtgaa gaattccatt 2634121 tttaatgggg ataaatatta atcataaaaa aacgccaagt cagcggttct ccgcttgagt 2634181 tggcgttttc tgctacttct tcagcaaagt aagcttatat ttgctttttg agtttatctt 2634241 ccatcagttc tgccatttgt tttgcatttg gattttcttc attttgcaac tgttcaatga 2634301 cgttcatata atccgtttca tttcggttct ggcttaattt atatgccgct tgaatgtctt 2634361 ccaccttaat cttaaatcca acaatacctt tcaattcact ttctaagagt tttggagaaa 2634421 gcttatccca taacacagga ttgtcacgat gtttttcgta tttctccaac atgattgtta 2634481 attcttctgc taattcatct ttctctaaca tacttgcttt tccatacatg tggacagcct 2634541 gataattcca cgtcggaaca ttttcgcgcg aataccagga agaagaaata taagcgtgcg 2634601 gtccctgaaa catcacaagc acatcttcac aggcttcaaa cgttctccac tgaggatttc 2634661 cataagcgaa atgccccgta atatagtaat gatcgtcttt tttattgaat cctaacggca 2634721 aatgtgtggc aattggtttt ccttgttctg ttgtgacaac cgtaccaaag gagttttctt 2634781 gtacaaaatt ccaaatttct tcagcatttg tgactttaaa atattttgga atatacatca 2634841 tcatccaccc ttcgaaaaat attatatgag tgttttagcc atgattaaat ccgtttgttc 2634901 ttcatcaccc atataaaatg agtgggcgcc ggtctgaaca aaccccattt tcttataaaa 2634961 ggcaatggca ttttcatttt tttcccacac acctagccaa atgttctttt tattacgttc 2635021 cagcgcaatt tctatcgctt tattcagcag atgtttgcca agcccatgtt tttgaaagct 2635081 gttctttata taaattctct cgatttcaag tgattcagca cccatttctt cagactgagc 2635141 atcatcgata ttgaccttta catatccagc gatttcatga tcaaagtaaa taaaaaagaa 2635201 ttgcgaagac atattagata actctttttc cagctgctca gtgttaaatg cgctttctaa 2635261 ataggctttc atattttcag gtgagttctg ttctttaaaa gtgtcattga atgtttcaat 2635321 actcaattgt tgaagtgttt gtaaatcttc ccggctgcat tttttcattt ttacactcat 2635381 tgttcggatt cagccccttt atttaaaatt caattgtctt gtgtcccttt tatatattta 2635441 aacacggaac acatactgac cttgttacca ttccaaaaat cttcttcatc accaactccc 2635501 tatcgtgatt ttgttgtaaa tgcaataaaa tatactccgc attaaatata tcgtaacttt 2635561 gctgtattta caacaaaaat caaacaacaa agcagcgttt ctcttgccga agttcccgga 2635621 actctctgca tcatttcccc ataataaaaa cgcctccctt aacgatgatt tatcgctaag 2635681 aaaagcgtca gtaatagttg ctatccgttt ttagtgctta gcactcttca ggcttgcctg 2635741 cattcgttgc tgttctgaac gaagaaccgc agccgcatga agcgatggcg tttggattgt 2635801 cgatggtgaa gccgccgccg agcatggatt gtttataatc aatcacggtg ccgttcatga 2635861 tgtcaaggct ttctttgtca actagaacag tgatgccgtg ctgatcaaac acactgtctg 2635921 attcactctt ttcatgctca aagcccatgc cgtaagaaag tccgctgcag ccgccgcctt 2635981 tgacgcctac acgcagaaac gcgttttctt cttcatgctc tttcatcata tcttttatat 2636041 gcaaagctgc tgcttctgta attgttaccg ggttgctcat cattatgaac ctccttttaa 2636101 aaaccggttg ctgtctttta ttataaacat gatcgttcca attctcaaac aaggtgtttt 2636161 acaagaaata gacaccctca caaacggttt cagccggccc tgtcatcatt acatggccgt 2636221 tatctttcca gtttatcacc aaatccccgc ctgctaaatg caccgtgatg tcttgatttc 2636281 gctttgatac gccgtttaat acagatgcga ctgccgctgc acatgctcct gtcccgcatg 2636341 cctgagtaat ccctgatccc cgttcccaga cgcggaaatg caattcttgt tcattcacgg 2636401 tttcaacgaa ttccacattg atgccttccg gaaatctcgg atctttctca atcaccggcc 2636461 ccagtgtcgt taagggtgcc tgttcaatgt ctgcgatcgg aaaaacgata tgcggatttc 2636521 ccattgaaac ggcagtgcct gttagttcta cttcaccaaa tgccatcgtt tcattgattg 2636581 tgtgctcttc cccgccgtca agcataggaa gctcggattt tgtcaagcgc ggttcgccca 2636641 tatcgacagt gaccacattc acttttccgt tttcgacttg aacctccgct ttcacaagcc 2636701 cggagagagt ttcaatcaga aaagatgttt cctcaaccag cttatgctca tatgcgtatt 2636761 ttgcgacgca gcgcaggccg ttgccgcagt ttttcccttc agacccgtca ttattaaaaa 2636821 tccgcatttt aacaggcgct tggtctgatg ggcatatcag gatcattccg tcggatccga 2636881 tccctgtata aacagaagaa acctgaattg caatctctga cagtttttct tctggaagct 2636941 gttcttcaaa ttgattcaca taaatataac tgtttcccag gccgtgcatt ttggtaaatc 2637001 gaaatgagtt cataggtgcc tccaactttt tttctttttc ttagtataaa agctattata 2637061 agcggacaca atacaattat cccccgtttt tcatacataa aagctccttg cactgacgca 2637121 aggagctttt atcgtttata taaacatgcc ggcaatggct gcgctgagca gattggctaa 2637181 tgttcctgca agaacagcct tcaggccgag acgtgcgata tctgaacggc ggctgggcgc 2637241 taaaccgcca agcgtaccaa gcataatcgc aattgatgaa aaattggcga atccgcataa 2637301 cgcgaaactg ataatggtag cagttttctt agaaaactcg ccgatgtgcg aaccgaagtt 2637361 agaataagcg acaaactcat tcagcaccaa tttctggccg atatagcttc ccgcctgcaa 2637421 tgcttcatgc caaggcacgc caatcaaaaa ggcgatagga gaaaacacat agccgagaat 2637481 ggattctaat gttacgcctt ttaaaccgaa caagccgaaa gccccgccga gaataccgtt 2637541 tactacagcg attaacgcaa caaacgcaag cagcatcgcc ccaacattta acgcaatttg 2637601 cagtcctgtt gacgctccct ttgcagctgc gtcaatgaca ttggctgcgc cttcgccttc 2637661 atccattttg aaatcgcttt ttacggtttg cgttttttcc gtttcgggta taatcaattt 2637721 accaaagact agtccagctg gagcagccat aaagctggcc gccagcaagt actcaatcgg 2637781 aataccgaga agcgcgtacc caaacaaggt agatcccgca actgccgata gaccgctcgt 2637841 cataatcgta aacaactcag agcgcgtcag cccggcaatc aggggtttga tcactaacgg 2637901 agattctgat tgtcctacaa aaatattggc agcagccgcc agagattccg ttttgcttgt 2637961 tccaaggagc ttcgacaatc cgccgccaat gacacggaaa acgagctgca tgattttcaa 2638021 atgatataaa actgcaatca gtgctgagaa gaaaatgata acgggcagta cacttaatgc 2638081 aaatgccgga ctgtctccga cctttagaag cggtccaaaa ataaaactga tgccttcatt 2638141 cgcatagtca atcagaagct gtacacggct tgaaaaccat aaaaaaacag cgcgtcccgc 2638201 ttcccatttc aacacgatgt atccaaacgc cacctgtgtg cataaaccaa cgatgacggt 2638261 tcttatctta atattgcttt tcttttctga aaataaaaac gcgatagcaa tgatcgcaac 2638321 tgcgcccagc agcccccaca gaacattcat gaatactcgt acacctctta aattttattt 2638381 aaaaaaatat cttttatacg ataacaataa tattttttga tgtctacaca tttttttagt 2638441 tcttttgtac ggcaaaataa aaaagggcct gtccaggccc ttttctttaa aacattggat 2638501 tttcttcaat aaaggtatat atattctcaa caagctcagc aggcgtttca cccatgacga 2638561 cttctccgtt taccagagcg aaaagcgatt ccatacatgt cccgcagtag cttaagcagc 2638621 catattcaag gacatcaagg ttgggatcct tctccaaaat cgcccgggct tcctgagagc 2638681 cgtgagccag attgctgaca caaaattcaa tcattggatt catgcggttt cacctcacat 2638741 atgtccatta tcgcgaattt ttcactattc gtcaaagaca acggatgatt caaaatttat 2638801 tatcgtaaca tattatttct caaataacgt tttactaatt tgtgttttca ggctaaattg 2638861 taggttattt tgaaactatt attgtgattt tagatcaaat tcgatataat tctagatgtt 2638921 attttacata gttcgtattt tcttcaatgt atctatcata ctcttcggat taaaggggaa 2638981 ttcaaatgaa aaaattggtc ttgatcggcg gaggttacgg gaacatgcgc gttcttcatc 2639041 gcttattgcc aaaccagctg cctgatgatg tttcaatcac gttaattgac agaaatcctt 2639101 atcactgctt gaaaacagaa tattatgccc ttgccgcagg cacaatttct gaccatcata 2639161 tcagagtgtc attcccagag caccctcgcc tggatgtcca atacggtgat atcacatcaa 2639221 ttgatattgt acaaaaacaa gtgctgttcc aagatcgtga accgatttct tacgatgacg 2639281 ccataatcgg gctcggctgt gaggataaat atcacaacgt gccgggagcg cctgaattca 2639341 cctacagtat tcaaaccatc gatcagtccc gcgaaaccta ccaaaagctg aataatctga 2639401 gcgctaatgc caccgtcgcc attgtcggag cgggcttaag cggcgttgag cttgcaagtg 2639461 aattgagaga aagccgtgat gacctgaaca ttattttgtt cgaccgcggt aatctcattt 2639521 tatcaagctt tcccgagcgt ttaagcaaat atgtgcaaaa atggttcgaa gagcacggtg 2639581 tccgcattat taacagggca aatatcacaa aagtagaaga aggcgttgtg tataaccacg 2639641 atgatccgat ttctgcagac gccatcgtgt ggacagccgg catccagcca aacaaagtcg 2639701 tcagagactt agatgtggag aaggacgcac aagggcgtat tgtattaacg cctcatcata 2639761 atcttccagg tgatgaacat ctgtacgttg tcggcgattg cgccagtctt cctcatgcac 2639821 cgagcgccca gctggcagag gctcaagcag agcagattgt ccaaatcttg caaaaacgct 2639881 ggaatggaga agccctgcct gaatcaatgc cgcagtttaa gctgaaaggc gtcctcggtt 2639941 cactcggaaa aaaagccggc ttcgggcttg ttgctgaccg tccgctgatc ggccgtgttc 2640001 cgcgtatgct gaaatccggc ttgctgtgga tgtataaaca ccataacggt taatgataga 2640061 gaagaaccgc tgatcaagtc agcggttttc tgtataccca tgcttctcca tttcctcata 2640121 aacgtctttt aattttggat tgccttcacc gacaattttg tcttctacaa gcacaagcgg 2640181 ataaaaatac tcgtcatttc tgattttttc cgcaagctct ttcgcatgtt cattgtcagg 2640241 cggctcatga atatcgatgt actgcatctc aaaaggctga tttggatatt ttcttttcag 2640301 cgcagcctca agccactcgt atgtatcctt ggctgtcggc atatttacac agctcgcaca 2640361 aacgttttct gccccgtaca cgcttagcat gactggtttc atcacttgta gacgccccct 2640421 tctcctatgt aagtcctttc ttttaagtat acagagccta agggcgtttt tatagaaaaa 2640481 aaccgttttt gtgttgaagt ctgaatgtgc tataataggg aaagcaactt tgcaaaccaa 2640541 acaatagatt tttattgtta cactgaatat aatggtttta tgacgacgaa aggagcgaat 2640601 gtcatgactg aagttgaaat gaaagaacag gtgcaggaag tactggacaa acttcgtccg 2640661 tttttacttc gtgacggcgg tgactgtgag cttgtagacg tagatgaagg tatcgttaag 2640721 cttcgtcttc taggcgcatg cggcagctgc ccaagttcaa caattacgtt gaaagccgga 2640781 attgagcgcg ctcttcttga agaagtgccg ggtgtcgttg aagtagaaca agtcttttaa 2640841 taaagcagcc aggctgatat ttgatcagcc tggctttttt attagagatg ttgatcaaac 2640901 catgagctga tataattcag gcgcttgatc cgctgtcttg ggtgtccggt gcgtgataaa 2640961 ttgtgcgatg cattcggaaa acggacaagc ttggtttcct tgcccatttt tttcagagcg 2641021 ataaacagct gctccgcctg ctcgatcggg catcggtcat cccgctcgcc atgcagtatc 2641081 aaaagcggtg tctccacgtt tgctgcgtat tttaaaggag accggtccca gagcttttct 2641141 gtgtcctcaa acatgtcatg ctcaagctgc cagtctgtaa agaaatagcc gatatcactg 2641201 acgccgtgaa agctgatcca atttgatatc gagcgctggg taacggcagc tttaaagcgg 2641261 ttcgtctgcc cgacgatcca gttggtcata aaacctccgt agcttccgcc cgtgacaccg 2641321 agccgcttag gatcaatatg cggatctcgt ttgatagcct catccacagc ctgcatcaca 2641381 tcgtcataat cctttccccc ataatctcct ctgaccgcat tcacaaattc ctgcccgtag 2641441 ccgtggcttc ctctcggatt gatataaacg accgcgtatc ctttcgccgc cagcacctga 2641501 aactcatgaa aatatgtatg tccgtacatc atatgcggac cgccgtgtat gttaagaata 2641561 agtggatatg ttgtctcacc ttccatttgt gcaggcctca tcagccagcc gttcaccatc 2641621 acgccgtctt ctgtagcata ttgaatctct tcaggtattg atatcgtatg ctccctgaca 2641681 aacttgtcat tcgcgccagt cagctgtttc tcttcctgtc caagcgggat actgtaaagc 2641741 tcactcggtc tgtccggctt tgtcacactg gcaataaagt gctgttcatc aggtgaaaga 2641801 gaaaagctat tgatgtactc tttttccaga cgaatcggat acacaaggcc ttcaatcgaa 2641861 atataataga tgcccgtact gccttgatct gtgccgatga cataaaaccc ttggctgtcc 2641921 tttgtccaaa tcgggcgctg ttcagcacca ccgatcaatg aatctccaat cagcgcatcc 2641981 gctaaatgaa cgtccagcat ctcagtaaga catgtgaggc ggccttgttc gatatcatag 2642041 agccacgcct ttgagagcgt agcattctta tattcctttt catttccaag caaagcaaga 2642101 taccttccgt ctggtgaaaa tgagcttgat ccgaatgagc cgcgatgagg tgtaacctgc 2642161 ttaagatctc cagactccag tgacattatg taaacatcat gcggcttgct ggcatcatct 2642221 gtttcagtta aattagctga gaaaacaagc catttgccgt caggagaaaa agcaggatca 2642281 ccatgatcag ctttgtgact tgtcagctct ttcatctcac ccgactttac gctgacaagc 2642341 acaagctggg catacgcacc tctcgtcagc cctttgccgt cccgtttgta ggagaggcct 2642401 tgcacttcaa caggttcata gctgtcctgc tctgtttttt ctcggtcatc aatgctttcc 2642461 ccctctccca aactgacagt gaccagaatc gattcaccgt ccggggacca tagcggcttt 2642521 gacacgccat atgggatatc agtcagtttt cttgcttctc cgccttcagt gctcatgata 2642581 taaagctgtg ccgcatcgcc ttctcgatca gaaataaagg caagcgtgcg cccgtccgga 2642641 gaccatcttg ggtcggtgct tcgcttttct ccatgtgtcc aaggaacaga tcctcccgtt 2642701 ttcgtttcat agatccatat atttgatgta tacgaatctt tctcttgatt tacttgtgat 2642761 tttacatatg cggcacgggt accgtctggg gcgtattgag gatcggtcac agagacaatc 2642821 gctgtgatgt cgtctgcggt tatcagcttt ttcatattca tctcctcctt tttacatgta 2642881 tttcgttttt ctaaataaaa actcctttat ctccagcaaa aaaaagcgcc ctccgctgac 2642941 gctgaggaac gcttggcatg atctatacac tttttacttg atataaagga tttcgctcta 2643001 ttatacttcc ctctttcgga acggtcaaag cgtctacttc acaatgaggg aaatgaagcg 2643061 cgagctgttc ttttagctct tctccctttc ctttttcggt catgacgaga atcgttgggc 2643121 ctgctccgct gagagccgtt ccatatgcgc ccttcatctc ggcgacgtgc tctacttttg 2643181 acagctcagg cacaagcatc gcccggtacg gctgatggaa catatccttc ttcatgattt 2643241 tcccgacaag cggccaatcc ttggacatga tcgcagcaat gaggatattg ctgacagcac 2643301 ttgcttttac ggcatcggca tatggaaact ccttcggaag cacgtctctc gcgtctcttg 2643361 tcagcacttc ataaaaagga atgacaacga ctacgtcaat gtcagcattc gggacgcgga 2643421 tcatttgggt ctcgtcatcc tcatgcaggc cgatcacaag tccgccgacg agagaagcgc 2643481 cagcattgtc cgggtgtcct tcttctagac tcgctaaatg cagcttgtcc gcttcagaca 2643541 gctttaagcc gcataattca tcagccagtt caatggccgc tacaatcgct gcggcgctgc 2643601 tgccaaggcc gcgtgcaagc gggatgtcgc tccacacctt cacatggaca ggaggcattt 2643661 cttttccgta caaatctgcg gtccgtttag ccacttggta gatcaggtta tctgtacccg 2643721 ccggaattcc ggcgactgtt tctgtttcag cctcaaaaga ccatttgtcg ctttcaaaga 2643781 cggtcagctt caaatatctg ctgagcgcca ttccgactga atcaaagccg gggcctaggt 2643841 tagctgtgct tccgggaaca gtgacagaga acagcatgtc ggcttcgttc atacacgggc 2643901 cgctcctttt acatattcaa ggatgctgtc ttcatcagtc ggcaatgtga caggcttgat 2643961 ttctgaaatg tcgaccgctg tgttcggatc tttcagtccg tttcctgtta acacagctac 2644021 gaccttgctg cctttcggaa tttctccgga tttcacctgt ttcagcactc ctgcgataga 2644081 cgcgcaagaa cctggttctg caaacacgcc ttctacacgg gcgatcagct gatatgcgtg 2644141 aaggatttca tcatcagtga cttcgtcaat tttcccattg gattcctcgg ctgcctttac 2644201 agctttgtcc cagcttgccg ggtttccgat acgaatggct gtcgctattg tttccggatt 2644261 ttcaatcact tcattgcgca cgattgccgc cgcaccctca gcttcaaagc cgcgcatttt 2644321 cggaaggcct gtgccgtttt tctcatgata ttccttgaag cccttccagt acgcagtgat 2644381 gtttccagca tttccgaccg ggatcgctaa aacatcaggc gcttccccca gctgttcgca 2644441 cacttcgaag gcagcagttt tttggccttc aatgcggtaa gggttgactg agttgacaag 2644501 ggcaatcggt gatttctcac agatggaacg gacaatttta agcgcatcgt caaagtttcc 2644561 gtcaattgcg ataatctcgg ctccgtacat gacagcttga gcgagttttc caaatgcaat 2644621 ttttccgttc gggatgatga caatgcattt catgttagca cgggctgcat atgctgccgc 2644681 agcagcggaa gtgttacctg ttgacgcgca cataatcgtg tcattgcctt cttcttttgc 2644741 ctttgccaca gccataacca ttccgcgatc tttaaatgat cccgtaggat tgacgccttc 2644801 cgttttgaca tgaagctcaa ttccgagctg ctcagacagc ttcggcaggt gaataagagg 2644861 tgtgtttcct tcatgtaaag ttagcgccgg tgtttgatct gttacaggta aaaattcttt 2644921 atattgatgg ataagtcctt tccacattag ctccaaccgt tcccttctac acgatatgtg 2644981 cttttgactt cttgaacgac ttccaaatca tttaggtttt gcaggatatc actgaaatca 2645041 gcttctgatg tatgatgtgt gacaattacg atttcagcta actcatcatg gcctttaatt 2645101 ggcagctgaa ggattttttc aaagctcacg ccccgctctg agaacacaga tgtaattttc 2645161 gagaatgaac caacctcatc ttttacatga attcttaaaa actgctgtgc ataaatgtca 2645221 gacggcgatt tcatgttttt ctcatattgc ggtccgacaa agctgttgcc ggttacacct 2645281 aggcgcatat ttttcatgac agcgacgagg tcagaaacaa cggatgtcgc tgtcggcatg 2645341 cttccggctc ccggcccgta gaacatcgtc tcaccgacag cctcgccgta tacataaaca 2645401 gcgttaaact cattatgaac agcagaaagc ggatgatggt caggaagcag tgtcggctgt 2645461 acgctgacct cgattttgct gccgtcacgc tgagcaatcc cgatcagctt cattgtatag 2645521 ccgaggcgtt tgctgaagct gatgtcctcg tctgtaattt gggagatccc ctttactttg 2645581 acgtcttcca gatccacgtt catcgagaag ccgaggcgcg ccaatatcgc cattttccgt 2645641 gcggcgtcaa gcccttccac gtcagaagtc ggatcagctt cggcaaaacc gagatcctgc 2645701 gcttccttga gcacttcctc gtatgggctt ttctctttga tcattttggt taagataaag 2645761 tttgttgtgc cgttcacaat tcccatcatt tttgtaattc gatctgatga gaggccttcc 2645821 tctaacgtgc gcagaatcgg aatcccgccg gcaacactgg cttcaaagta gatatcgcat 2645881 ccattttcct tcgcttcggc aagcagctcg gagccgtaca cagccattaa gtccttgttt 2645941 gctgtgacaa catgcttttt cgatctcagc gcgtcgacca aatattgttt tgtctgttca 2646001 acgccgccga tcacctcgat gacgacatca acatctggat catcaatgac atcatacact 2646061 tctgtcgtga gcacttcctt cggcaaatct acttctctct ttttctctaa atcttttaca 2646121 agcacttttt ttatcgtaac cggacagccg acctgatgca taagcttatc ctgatggtct 2646181 tgaataattt taacgacacc gcttccgacg gtacctaaac ctaaaagccc tacacgaatc 2646241 gctttcaaaa aaactccacc tttcttttga ttgtcctctt ggaaaagaca attgttaact 2646301 caacacagac atataagtta caaacattat ataagcccgc tcctgttttg acaagacatc 2646361 attaggctga attttgcgaa tgtaaacgct taacgcattg atatgacaag attctttatt 2646421 ttctaattat ttttgtcaga ttttctcctc accttgagct gcctttgccg agccagctga 2646481 cgcgtggaac aaacagcttc tgcgcccgca tattcatgaa ttcctgcgct gtattgagaa 2646541 attgttcata acgcccacag tcattaagaa tgaagtcaag ctgttcttca aaataatgct 2646601 tttctgattc tgatgacatg taatagcttt ctacgatttc aaaataatga agcgggaaaa 2646661 gcagacggct gtataaaagg cgtttcgaaa atgaagacag cggtgtgact tgctcgtatt 2646721 cctgtaaaaa gagaaagccc tgctgattaa aatcttgtct gtgatgcaaa aacgtatgcc 2646781 tcatatattc agccaaatca cgggaagcgt ggtcaaacac ccaatccgcc ggaatcctga 2646841 tcaatgattc cggtgaccat gtatgccttt ccatccgctg atggcatatc gttcctgaat 2646901 cagcggcttg gggcttgtca tccagctcag tgtccactaa atattgtatc gcgttttctg 2646961 acagtcctaa ataatatgga aatgattcga tcattttttt atcgaatggc tcatgcggag 2647021 gggtctgaac ctttctctgc caaaatgctt ccagctgatc aattcgtttt ccccacagat 2647081 ccttccactg gccgattctt ccggccgcct tcacctcata tggatatcct cggccttttc 2647141 ggtgaaattc cgcaagctcc gctccaatgg agaacgccct gtttgaataa gggggggccg 2647201 ccttcagcag agcgtacgtt tttccctcat gttcaaatgt cagttcacct tcttttgtaa 2647261 agataaaaac cgaaacgtat gggtcacttt gttcttgtaa atactgactc atgtaataaa 2647321 gctccgccag ctctgtttct gagaattggg aaacggggac aatcagaaag tatgaattag 2647381 gcgtctgaaa gcattgatat gtgtgctggt acatggaaag ctgcctgatg tgaatgccgt 2647441 atttttcttt tattgtacct ttcaccatga tcacctgcct gttgaattag ggctcatcac 2647501 atcgtagtca tacacagccg gaattatgaa tacatatttt aatccgaaga aggcgcaaga 2647561 aaaagtcgta aacttctcaa gcattttgta taaactagta aaaaagattg ggtgaagctg 2647621 atgtcagaaa acgaacaatt cagtcagatg gaagctaaag caagagcacg gatgaaggag 2647681 cgcggcgttg aggtatcaga cattgccgag cttgtctttt ttctgcagaa aaaatatcat 2647741 ccggatttaa ccattgatga atgcacgctg aacgtcaatc gtgttctcgc aaaacgcgag 2647801 gtgcaaaacg cgattttaac gggcattgaa ttggatgttc ttgctgagca gaaaaaattg 2647861 tctgaaccgc tgcaaacgat gctggaaata gatgaaagcc tatatggagt agatgaagtt 2647921 ctggcatttt ccattgtgaa catttacgga tcgatcgggt ttacgaacta cggttacatc 2647981 gacaaagaaa aacccggaat ccttaaacga ttgaatgata aatcaaccgg tgaatgccat 2648041 acctttttag atgacatcgt cggagcgatt tccgccgcgg cttcaagcag acttgctcac 2648101 cgcgcgcggc atacagaata agggcaccct tttagggcgc ccttttttca aatgtatgga 2648161 atccattcag tcagagagtc aatggcgtga gtcggttttt ccatatcgtc tgtcatatgt 2648221 tctcttttcg ttacgcctgt gtgaacgagc agcgtatcca tacccgcgtt aatgccggcc 2648281 ataatatcag tggcgtagtt gtcgccgacc atgagtgttt cagacacatc tgtgccgaga 2648341 acgcgcatcg cctgctccat aataattgat tccggcttgc cgataaatac aggctgtaca 2648401 cctgtagata cggttaacac cgatgtcagt gagccgtttc ccggcaggag ccctctttca 2648461 gtcggaatcg caatatctcc gttagtggaa ataaagcggg cgccatttct gattgccagg 2648521 cagccaacag caaatttttc gtatgtaatg gaacggtcga tgccaacaac gacaaaatcc 2648581 gcgttttctc cgccaaatgt caggccgttt tcttcaatcg cctggcggat tccttcctcc 2648641 ccaatcacat acacagacgc gtcttttttc tgctgtgcaa tgtgctgggc agttgccatg 2648701 ctggtcgtga agacctgctc ttctgttgcc ggaatatcaa aagacacgag cttgtccgct 2648761 acctgcttcg gtgtgcgcga agagttgttt gtcacgaaaa gataaggaac gccgcgatct 2648821 ttcagcgttc tgacaaattc acacgcctcc tcgatttttt ccgtgccatt gtacatcgtt 2648881 ccgtctaaat caattaaata ccctttatat gttttcatat ccaacactcc tgtggctttc 2648941 cagttgttat ttaaacgcgg aaacaggtcc tagctctgtt tccaaatagc ttctgatccg 2649001 tttcgggaag tcctgaagag ctgtttgatg cgccttgatc agcctgtaaa gctcgccgct 2649061 gtcagcgagc agatactgtt gaaccaacgt tttgcggtag gcgatcaatt ttttgagctc 2649121 atcaccctct ttttccgtga caactttctc atcaacaagt atatccataa tgtcgtcata 2649181 gctgcccggg tcccgcataa taaagccgtc aatcatgtca ttgcctgtat ccaaaatgca 2649241 ttcgattaac agatggccta tacgctgaag tgccaattcc ccgatttcag actgccagtc 2649301 tgtttgtgag tcaaatagcg ccagctggtg ctcgaagaac cctagtgttt tttcgatttt 2649361 gcttctgtca acaaaataca tgacagcatc ccctttgtgt atatttattt tctgatccgt 2649421 ttcaagacaa aatacgcaca gccgaaattg cagtattcgt aaatatattc atctaatgtg 2649481 ctgattttcg tttcgaaggt tgccttttga ttctggtcgt caaagaagcc cttgagcctt 2649541 aactgaccgt atccccagtc tcccacaata taatcgtatt tatttaatat atcggagtag 2649601 cgggctttaa aagcctcttc gttgaagccg tctttgaaat tgtgcaccaa ttcaaattcg 2649661 gcattttgaa taagaatcat gatctcacct cttttttcac tcattcctat cataattcat 2649721 tgccccgtcc ccatcaattg ctaaagaata aatcatgcga tttggctacc ctacacatga 2649781 ggagggattg ataaatgaaa cgaaccgctg tcagcctctg cctgctgacc ggactattat 2649841 ccgggtgcgg aggcgcagga ttggataatg cccaaaatgt ccggaatcag acgcagaatc 2649901 aaaccaaacc cattcatgtg tcggaccgca acgaggcttt taacaggcat aatgagaacg 2649961 aacaatttgg ctatgtccgc tatcaaaaag aacaatttga cggagaacag cagaaaacgc 2650021 cggtgatgaa ccgggaagaa accgctcaca tgatatcaag tttaacggtt cagctccccc 2650081 atattcaaga tgctgcgaca ttggtgactg accgagaagc gcttgtcgta tacaaaaccg 2650141 attctaaaaa ccgggagctg accgccgatc aggtgaaaaa aacagcggct tctgtgatac 2650201 cgcgatacta tcacgtgtat atttccgata atccaaacca tatgcaatcc gtcgaaaatt 2650261 acagcaatct cggctctggt tcaagggata ttagagagat catgtcgggg acgattcaag 2650321 aaatgaaaac ctccccgcaa ggaagccctg tctcagagaa tgaaaatgcc aatggagaaa 2650381 cgcgtcagga catgaaaatc gataggaatg acaaaaacgc cagatgatct ggcgttttgg 2650441 cattatgctt gtgcttgacg ctttttagat gcttcgttta cttgttcatc cgcatggtaa 2650501 gaggaacgga caagcggacc ggcttcacaa tggctgaagc ctttttgcat cgcgatttct 2650561 tttaattctg caaattcatc aggatggtag tatttttgga ctttcaagtg tttcttcgtc 2650621 ggctgcagat attggccgat tgccataata tccacgttgt tcgccaagag gtcgtccatt 2650681 acttcaataa tctcttcttt tgtttcgccg agtccgatca tgatacttga ttttgtcgga 2650741 atgtcaggct gcatttcctt cgcacggcgc aaaaattcca atgaacggtc gtacgtcgca 2650801 cgcgcgcgga ctcttggcgt caggcggcga accgtttcga tattgtgatt caggatgtct 2650861 gggcgtgtat ccatcaaggt ttttaggtta tcgtagtttc cgcccatatc agacggcagc 2650921 acctcaattg ttgtgaacgg gctttttctg cggatcgcac ggacagtttc cgcgaaaatg 2650981 cctgccccgc catctttctg atcgtcacgc gcaacagccg taatgaccgc gtgtttcaaa 2651041 ttcataagcg cgactgaatc cgctacgcgt tccggctctt gcagatcaag ctcagttgga 2651101 aggcctgttt tgacagcaca gaaacggcat gctcttgtac aaacagaacc taaaatcata 2651161 aatgtcgctg tacgtctgac cgcccagcat tcatgaatat tcggacactt tgcttcttcg 2651221 catacggtat gcaggttgtt ttcccgcatg agttttttga gccctgtata gttttcattt 2651281 gtatttaatt taattttaag ccattcgggc tttctgaggt gttcgtcttt ctttgccaat 2651341 tcccatcatc tccaatatcc aatatactca atttctgaca cgaaacattc tgaaaacgag 2651401 aaaggtgcag gttttagttc tgcaacaaaa ataatgtttt tctaactaaa gaaagtcttt 2651461 tctttagaca ctttaacata ggaaaaattt ctcgacaagg gaagatgatt actgacattt 2651521 ttaagccggg ttgccgcaaa ctatgtgtat tcaatatgaa aggagattat tttgtgaaag 2651581 ttttgttatc cgctcttctt ctccttttgt ttgcatttga gccttctgcg tctggaaaaa 2651641 aactttcaga tccagtgctg tcgaaacgga tggaattata tcataaaatc gaagctgtga 2651701 cgcagatccc ttggtatgcg ctcgccgctg ttgatcaata cgaagaaaac gtgcggagca 2651761 accggaaaga tctgcctgaa aaggcgggaa tcatcagcat ctatataccc gatgatatct 2651821 ggagcgggcc tgaaaacccg aatccgaaag acgatgcgcc gttaagcatt aaagtgtttg 2651881 acggaatcgg aatggatggc gatggagacg ggaaagccga ggtcagcaac gatgaagata 2651941 tcttgtatac gttcagccaa tacttactgt cgtatggcac agatgaagac aacatccgga 2652001 tcgggctttg gaattattac cggcgtgatc agacagtggg gattatatct gaattcatga 2652061 agctgtttaa agcctacggc catattgatc tgggcgagca tgcattcccg cttccgatca 2652121 gaaccgatta cagctaccga agcacgtggg gagatgcccg cggcttcggt ggaaggcgga 2652181 ttcatgaagg tacggatatc tttgcccatt acggccttcc tgtcaaatcc acatgttacg 2652241 gcgtagttga aatgaagggc tggaaccgct tcggaggatg gagaatcggc atcagggaca 2652301 ttaacaatac gtatcattat tttgcccatc tcaatgggtt tgccaaaggg attaaaacag 2652361 gacaaatcgt tgagcctggc caagtgatcg gatcagtcgg cagctccgga tacggcccgc 2652421 cgggaaccgc cgggaagttc ccgccgcatc tgcactatgg catgtacaaa gataacggaa 2652481 gaaccgaatg gtcatttgat ccatacccgc atttgagggc gtgggagcga tatgaatacc 2652541 aaaaaaagaa gtaacaaaaa gccgcctctt caacaggcgg cttatttgct gcttttttct 2652601 ttttttgaat cggcaccgtt ttctttgctg ctcggaagct ggacagaagg cgtgacaccc 2652661 gagccgccgc ttccattata aaactgcggc acttcgccct gcactgcttt aatcgataca 2652721 ggaacattat ttgtgacgac agcggttttg ctggcaaatg gaatgatgac cttcacttta 2652781 atttcgacaa agatgctgat atcaataagt gcgttattta tgccatacgg cttgattttg 2652841 gttttgacat ctgtaaaagc gtcaccgatt aaattgaacc ggaccgggat tttcggcccg 2652901 aggtttccaa gaaggctgtt gccggttacc tgtcccagcg gaatgttgat cataatgttt 2652961 tcactggcgc cgctgtgtcc ggtatgggtt tccatctctt tcaaatgagc ctgaagctgc 2653021 tttgtcactt ttgttttcac actgtttaca acctgtgtat taaaatcgat tgtcgttaag 2653081 tttccgtttt catcagaatt catttgaaac atatctttca tattttcact gtcagacata 2653141 tagtcctcaa tcgaatcctg gatcacctct gtcgctatac gcttcgtttc catctcgccg 2653201 atgtccatta aaacaggttt gatcgagcca ttgatcatcc aaaggctgac cgttgttgac 2653261 aggataaaaa agacaacgga caggagcatc acgtaacgga aaggcaaagg tcctctcttg 2653321 cgaaaagggc cgcgatatct tggcaagaaa atcccccctt acatatcaca atgtatgctt 2653381 gtaagagggg acatagtaat agccggggcc aatttatttt atttcatcat ttttaaaagc 2653441 gcttctctgc cgctcatgcc gactttgatg ccaagatctt ccgcagcgta cgtgacggat 2653501 tctaaaggtg cgtctaacag ctggtcaatg gtgcggacac caactgcgcg tcccgccacg 2653561 atgccgcgct cctttaattt ttcattcagc agcgccacat caagcgcgcc gcacataatg 2653621 tatccgtgat cattggcgac ggccataaaa ttcgttttgg gaagctttac tgtcacagct 2653681 gtaaaaggct gtccttctat catgatcggt gtcaggttta ccacgtcaac cactcccttc 2653741 attcatcact ttatgatgaa gggcacagct tgttgtgggc tgactgcctt attgtgcaag 2653801 cttccaagca agcagatccc gcaaaaattc cggcataaaa tattcttttt ctgcagcgtc 2653861 gcgaatcaac ggaaacagtt tgccgagcgt aaacatatca agcaccgcaa cggagtattg 2653921 tttatgtttt tcaatatctt ccccgttcag tgtgatccga gtgacgtggg tgatcccgtc 2653981 atcgagccgt ttcgtttcta cctcaacgcc ggcatacacc attttcccca tcacttctcc 2654041 gcggaagccg agtcctttga tccggagctg ctccatttgt tcggaagcgg catggacaat 2654101 ggtttccttc agttcttctc ccgtcaggcg gacagccacc gggttgatcg gatgcggaca 2654161 gatgcggtgc agatccagct ttgtcacagg acctgctttt agcggaccga gaatgacacc 2654221 tgaattgacc atactgatgt ccgtctcgca ccattccttt aaggcgtatg ccaaaagcaa 2654281 aggcagctct gattcttcaa accacttcac ctcagcatct tgtgcaagct ctgcaacggc 2654341 atcggacagt ttctcctcgg cttcacgttc tttttcattg agaaacgctt tagtttctgc 2654401 ggattctcct gtccattccg ccatgttctg cacagaagcc gttttgctgt tgatgcttcg 2654461 ctgtacgctg tccaccgtga tttctacaca gccgacataa tgcccgtatt tctcggcgct 2654521 ggccagcagt accccattaa ccacttgtcc atcttcgagc aaatgatggg tatgtgattc 2654581 gaggattaca tcaatctcag gcaccgcttc agccactgct tgatcatcaa gaatgcctaa 2654641 atgtgacagc agaacgataa tatcagcctg ccctttcact tccagaatgg tttcctttat 2654701 gctttcaagg gcatccgtaa ctgtccatcc cagcttgtca tatacaggat aatacggcac 2654761 agttacacct aagaaagcaa tggacatacc gtttttcaat gatttgatat ggtaaggcac 2654821 cgcccaggac ggacggtttc catttttatc aaacaggtta gagacgatga caggaaattc 2654881 agcatgatca tataaggcag caagctcttc atgcggaagc gtaatccctt cgttattgcc 2654941 gatcgccgct ccatcaatgt gaaggcggtt taagagatcg acattcgctt ttccgaatgt 2655001 cgcctctgtc acgaattgaa aacgatcaag atgatcgcca atatcaaaaa cgagcgtctc 2655061 ttcgccgtct gactgatgct cttttctttt ctgctcgata taatctacaa ttttcggcca 2655121 gttttcaaaa tggctgtgca aatcatttgt atgatataag cggagcttct ccttcataat 2655181 atctctccct aatcgttcag ctgaaaatgc cttcataaat gagctggcag ccgatcaaaa 2655241 tcaatacgat ccgcatgatc ataacgatcg ttttcgtctg catttttctg ttgatggcgg 2655301 cgccaagctt tccgccgaac caagcgccgg gcacaagcgc gagggcgtac agccaattga 2655361 cgtgcccgga aatcatatgt gaaacagacc ctgtcataga agacaggaaa ataataaaca 2655421 tggacgttgc caccgcaacc ttcggcggaa acagaaataa cagcatcatc gccggaacca 2655481 tcagtgatcc gccgcctata ccgaaaagtc cgcctaaaaa accgacaaca aaggcaatgg 2655541 caataccgac agaggcctga tatgagtacg tataaggctc accggcatca tcctgaaatg 2655601 tccggataat tcctttgtgc gctttgttga ttggccgggc tttcgctttc agcattaagg 2655661 ataatgaaat cagaatcata aaaatgccaa accaaacgga aaacgagttt gaattgaaca 2655721 gctttgacac gtaagccccg atcatgctgc cgggacccga accgataaag aaaatgagtc 2655781 cgctcttata atcaactgtt ttatatttaa tataagccaa agttgaagaa aggcccgtaa 2655841 aaataatgac caaaagcgaa gttccaatcg caacctgcgg cgtcacatcc tgaaacagct 2655901 gcgtcactgt gcttaaaaac atcagagatg gcacaatgac aattccgccg ccaagcccga 2655961 tcagacttcc taccgtacct gcgattaatc ccagtacgac caaaatcaca aacgacatca 2656021 atcaaaacct cttttctaaa ataaatcgag ctgtctcgga gcaagtccgc tgtactcgat 2656081 atcaagcagt tcaagcatct gcttgccatt atccgcagcg tcaccgccgg aattgttgtt 2656141 gaacaggaca aaaacatcct tacattgctg ctgcaattca ttcaggtgct ttttccaatc 2656201 ctccagctcc tgttggttgt agcggtataa gtacctgacc tcccgccagt ttttcccgcc 2656261 atcaggcttc atccagccct gcttgttgcg tccgtgaaac ctgacgagcg ttttgttttc 2656321 atcggtcgcg cgcaacacgg tcggaacgct gccttctccg atttgcggtt catcacagac 2656381 actgtgaatc cagccttccg ctttcataaa tgaaagcgtc tgctcataaa atggcggcga 2656441 gaaccaggaa cggtttctga attcaagcgc gcaaggaata tctcccattt ggtgcttaca 2656501 ccatctcaaa taggcgacat tctccttctt gcagtcaaac cacggcggaa attgaaacag 2656561 caccatggcg agcttattgc tatgtaaata tggcgttaaa gacaccttaa acgcatcaaa 2656621 catctcctct tttgagtcaa agggaatttc gccgcgctga tgccctgtca tgccctgata 2656681 tgctttcacg ataaattgga aggtttcggg cgtttccttc acccactttt cattattgcg 2656741 cgccggctga atcgcgtaaa agctcgcgtc taattccacg atcggaaaat gggaggaata 2656801 ggcctgcaat tttttctggc tggccgtttt cggcggatag atgctgtcat gatcccccca 2656861 tcccgtcagt ccgatataaa tcacactcat tcacctctct tccagtttat cacacgtgtt 2656921 ttcaggtttc ctcggaaatg ctgttcatat ggcgggaaaa tgcctcacgc aaatgctgat 2656981 attgttcctc attcgtatct aaaaacgcct cttctcttga ggaaggaatg tgctgatatt 2657041 caataggcgc ctgaaactgc tcactcgtaa aatcgtacac cacaccattg atgctgttat 2657101 aaaaatgcca gctctcatcg actcttgttt tgaaaatcgt gccgccgaaa tggtcttgaa 2657161 tcaccaatgc cgtcacgccg cattggccgc atgacgggca ttcttccgtc catttagagc 2657221 tcgaatggcg cgaccaggat tgcttaagta tgtatttgac atgctccatt gcctccgcct 2657281 cctttaaaaa aagataccac gttgatgaga ttttaaaaac tagaacggag gaaatcaaaa 2657341 aacccggcgg taaaatccgc cgggcttacg aaggaacgac cagagctccg tcaatttcag 2657401 tgactttttc cccatcattg tacacgcacc ggcctttgct gtaagtggcc gaaatgctgc 2657461 agggaaatgt atgtccttcg taaatgcttt ttttatgctt tgcaaacatc gattctcttg 2657521 taacagtgta cggctccatg ctgacgagca cgaaatctgc atcacacccc gcctcaagcc 2657581 gccctttttt ctgaaggccg aatcgttttg caggggccgc cgctgtccat tctgcgatgg 2657641 tttcaaatgg aatctgatgc tcaagcgcca gttccagcat tcctaataaa gtgaactgcc 2657701 cgccgctgat tccgccccat gataaaaaca tgttatcctc ccgcttcaag gatggacggc 2657761 aaggggaatg gtctgaggaa accatgtcaa tgtccccggc aatgagcgtc tcgatcagcg 2657821 tctcttttga ttgccgtgac cggagcggag gcgcgcattt tgcgacagag cccctttgcc 2657881 gtaaatcgtc atggctgaac aagacataat gcggacatgt ttcaaccgaa acatcaagac 2657941 cttcctgttt cgcctctctg atcagccgga ccgctttcgc cgtgctgata tggacaaaat 2658001 gaaccggaca gcctgtcacc ttcgcatact gaatcgtgcg atacaccgct tcaacttctg 2658061 cttcctccgg gcgggaggcg gcgtacgcat ccgcatccac ctttccttta ttggccaaaa 2658121 ccatctgcaa gtagcttgtg atcgcgtcgc tttccgcgtg gagagcgagg atttttcctg 2658181 cagccgcgat ttctgccatg cctttgagca atgtccgttc atcaacagag cggaactcat 2658241 cagtgcctga ctttgataaa aacgctttaa acccgatcgc tcccgcttca gccatcggac 2658301 ggatgtcctc gatatggcct ggcacaaggc cgccccatag cgcaaaatcc acggcagatt 2658361 tttgcctgcc tagctcagct tttgcgagaa gatgctctgc cgtcacggtt gatggaatac 2658421 agttgagcgg catatcaaaa taggtagtgc aaccgcctgc ggccatcatt tgagaacctg 2658481 tttcaaaccc ctcccaatcc tccctgcccg gttcattaaa atgaacatgg caatctatca 2658541 caccaggaaa cacgtatttc ccgtctgcct ggatgatttc cgtcccgctt gcttcaatgt 2658601 cagaacctat ctcggcaatg acaccgtttt gaactacaat atcagcttct ataacgccat 2658661 ctggcgtaac tgccttcgca ccttttatca ccatatcgta agccatattg atccccccat 2658721 gtcaggatga cgattttcca tgtcagttta tgtaacacaa ccagttctat tttcaacagt 2658781 ttactgctac tatgatcgta ttacatcagc aaaaccgcta gaattcctat tgaaaattat 2658841 tcaccttaac caatgttttt atagaaaagg agaatgcgct atgaatattc ttgatgtgat 2658901 gaaaataccg gcttttgaaa acgccaattt aatcgctgga aaagcaggag gggaaagaga 2658961 ggttcagcat gtcaatatga tggacgctcc ggatatcgta gactttttgc ataagaatga 2659021 attgctcgtc accaccgcct atcacctgaa ggatcacccg catcaattat ctgaactgat 2659081 tcggcaaatg gcaaaacgcg gctgcgcggg cctcggcatt aaaacaaagc gctatctgga 2659141 agatatcccg aaggaaatca tcgaactggc cgattcatat gcgtttccga tcattgagct 2659201 tccggaacac atccgactcg gcgatattgt gaatgccaca ctcagccata ttctcgatat 2659261 gcgttctaac gagctgcagc aagccattta cgcgcacaaa aaattcacaa accacattat 2659321 gagcggcaag gggctgcaat ccctcctcaa aaaggtgtca gacatccttc agcttcccgt 2659381 gctgctgctt gaccagcatg ccaaaatgct gtctgcgtct catcagattt cagttgagac 2659441 cgaaaagctg aaaggcaccc tgaataccgt atccgggcca tttttcactt gtttctctac 2659501 aatctcagat cagaaaacat attctgtcct gcctatttat aatcacgaaa aaaactgcgg 2659561 ctacctgctg atacccgaca tggtgcaggc aggcgacaaa ggattgatcc tcacgattga 2659621 acaagcggcc aacgtcattt cctttgaact gctgaaggaa aatgcgctga agcagttcag 2659681 ccggcgggcc cgcaatgagt ttttcaacaa ttttattgag cggacctttt cttcagatga 2659741 cgaaatcaaa aaccgggcga aagaattcaa gctgcgctgg gatcaaaaat acatgtgcat 2659801 cgccggcaaa ctcgatcgca atgacgaatc aatcagcttt acagaaaatc agctcgcttc 2659861 cgacagcgta ttcgaatttc ttgaaggtga attatcagcc ttcccgtttc cacctcactt 2659921 ctttatgaaa ggaaatgtcg gcattattct aatcgaggcg acagacagct ggagtgaaat 2659981 gcacgcctcg gtgatcagct ttttagaaca gtttcaaaca caggtcagcg ctcaatttaa 2660041 acgaaccgtg tcctttggca tcagcaatat ctgccaaaag ctcattgatg ttcccgacgc 2660101 tttcacagaa gcttctgatg ctctgcaatc ggggcatttg tcaagaagca ccgcatttat 2660161 ccaggtgtat cacgccaaag atgtgcctga gcttctgcgc ttgctcccag ttgaggattt 2660221 gaagaaattt tacaactcca cgcttcagag cctcgctgaa aaacagcagg aggatcaaag 2660281 cctgcttcat acgctttccg tctatttaga gacacactgc caaatttcag agacggcaaa 2660341 gcgtctgtac gttcatcgca atacggtcat ataccgcctt gaaaaatgcg aagagcttct 2660401 ggggaaaagc ttaaaagatc ctgaaacaac gatgcgtttg cggcttgcat tacgtatgca 2660461 gcggctgatc agctaaagtt tgttacattt tcttacaaaa cgaatcgttt ttcgtcactt 2660521 tcagcaatca cacctgtctt tttcagctac tgtatccaat gacacccctc gaccggaacg 2660581 atattatgtt actaaagttc acatacaggg agggactata gtgaaaaaaa gatcgtttaa 2660641 ggtgtttaca cttagcctgc agcatgtgct cgccatgtat gcaggtgcga ttttggtgcc 2660701 cctgcttgtc ggcagggcgc tgaatgtaac aactgaacag ctgtcctacc tattggcgat 2660761 tgacctgtta acatgcggcg tcgctacgct tttgcaaacc ttgcgcggaa catacatcgg 2660821 catcgggctt cccgtcatgc ttggcagttc atttgtggcc gtcaccccaa tgattgcaat 2660881 cggcagcaat tacggcattc acgcgattta tggttccatc attgcggccg gtgtgttcat 2660941 ctttttgttt gcgcgttttt tcggcaagct gactgtgtta tttcctcctg tcgtaacagg 2661001 taccgttgtg accttgatcg gcctttcact tgttccgaca ggtgtgaaaa atatggctgg 2661061 cggcgaaaaa ataaacggca gcgccaaccc cgaatacggt tcgctcgaaa accttcttct 2661121 ctctgtcggt gtccttgttc tgatcttagt cctcaaccgc tttctcaaag gatttgcccg 2661181 aacactgtcc gttctgatcg gcatcgccgc cggaacagcg gcagcagcga tcatgggcaa 2661241 agtcagcttt tcttctgtta cagaagcacc gttcttccaa atcccgaagc ctttttactt 2661301 cggagcccct gcgtttgaaa tcggtccgat cttaacgatg ctgatcgtcg gaatcgtcat 2661361 tattgtggaa tcaaccggcg ttttttacgc aatcggaaag atatgcggca gacctttaac 2661421 tgacaaagat ctcgtcaaag gctatcgagc ggaaggaatc gccattctca tcggcgggct 2661481 gttcaatgcc tttccttata atacctttgc gcaaaacgcc ggcttattgc agctgaccaa 2661541 agtgaaaaca agaaacatcg tcgttaccgc aggctgtatc cttgtctgtc tcggactgat 2661601 tccgaagatt gccgcccttg catctgccgt tcctgctgct gtacttggcg gcgcgaccgt 2661661 cgtcatgttc ggcatggtga ttgcctccgg cgtcaaaatg ctcagcacag cggatctcaa 2661721 aaatcaatac cacctcctga ccatcgcatg ctcaatcgca ctcggcatcg gcgccagcac 2661781 ggcccccggg atttttgctg aattccccgc tccgatccgg attctggtca gtgacggcac 2661841 catcaccgga agcctaaccg ccatcttttt gaatctattt ttcagcttgc gcgacaaaaa 2661901 agaattaaca gcacagcaaa cagaacttcc ggtattagaa catacactcg cattagaaaa 2661961 agaggtgtaa aaaagatgaa ggaacagcac aatgccttac agctaatgat gctggggctt 2662021 cagcacatgc ttgccatgta tgcgggagcc attctcgttc cgttgatcgt cggagcagcg 2662081 atcgggctga atgcggggca gctgacgtat ttaatcgcga ttgatttgtt tatgtgcggg 2662141 gcggcaactc ttttgcagct ctggagaaac cgatatttcg gcatcggcct tcccgttgtg 2662201 ctcggatgca cgtttaccgc agtcggcccg atgatttcca tcggaagcac ttacggtgtc 2662261 ccagcgatat atggtgccat tatcgccgca ggactgattg tcgtcttagc cgcgggcttc 2662321 ttcgggaagc ttgtccgttt ttttccgcct gtcgtaaccg gatcagtcgt catgatcatc 2662381 ggcatcagcc tgattccaac ggcaatgaat aacctggccg gaggtgaagg aagcaaagaa 2662441 ttcggctcac tcgacaacgt gctcctcggg tttggcgtca cagcttttat cttattgctg 2662501 ttttatttct ttaaaggctt tatccgctcc atagcgattt tactcggtct tatcgcagga 2662561 acagcggctg catatttcat gggaaaggtc gatttttctg aggttttgga ggcgtcttgg 2662621 cttcatgttc cgtctctgtt ttatttcgga ccgccaacct ttgagctgcc ggctgttgtc 2662681 acgatgcttc tcgttgcaat tgtcagcctc gttgaatcga caggcgttta ttttgccctc 2662741 gctgatatca caaaccgcag gctgtcggag aaggatctgg aaaaaggcta ccgggcagaa 2662801 ggccttgcga ttttgctggg cggcttattt aacgcgtttc cctatacagc tttctcgcag 2662861 aatgtcggca tcgttcagct ctcaaagatg aaaagtgtca acgtcatcgc catcacagga 2662921 atcatactgg tcgcgatcgg gctggttcca aaagcagcgg ccctgacaac agtgatcccc 2662981 accccagttc tcggcggcgc aatgatcgtc atgttcggca tggtcatttc ttacgggatc 2663041 aaaatgctat ccagcgttga ccttgattcg caaggcaacc tgctgattat cgcctcttcc 2663101 gtcagcttgg ggcttggcgc tacaacagtt cccgcgttgt tttcatctct ttcgggcgcg 2663161 gcctctgtct tggcaggaag cggaattgtg atcggcagtt tgacggccat tgcactgcac 2663221 gctttttttc aaaccaaaca gccgaatagc gcagacataa aaacgtaaag gaagatgcca 2663281 atgttcacaa tggatgacct gaaccaaatg gacacacaaa cactgacaga cacacttggc 2663341 tctatttttg aacactcttc atggattgcg gagagatccg cagcactacg gccgttttcg 2663401 tccctttctg atcttcaccg caaaatgact ggcattgtaa aagctgcgga tcgcgagaca 2663461 cagcttgatt taatcaaaaa gcatccccgg ctcggaacaa agaaaacaat gagcgatgac 2663521 tcggtacgag agcagcagaa cgcagggctc ggcaaattag aacagcagga atacgaggag 2663581 tttctcatgc tgaatgaaca ctattatgat cgcttcggct ttccttttat tttagcggtg 2663641 aagggaaaga cgaaacagga cattcaccaa gccctgctgg caaggcttga gagcgaacga 2663701 gaaacggagt tccagcaggc ccttatagaa atttaccgaa tcgcccgctt tcgtctggct 2663761 gacatcatca ctgaaaaagg agagacgcaa atgaaaagaa ccatgtctta tggcaaagga 2663821 aatgtatttg cataccgaac gtatttaaaa ccgctcactg gagtgaagca aatcccggaa 2663881 tcatcttttg ccggaagaga taataccgtt gtcggcgttg atgtgacatg cgaaattggc 2663941 ggagaagcct tcctgccatc atttacagac ggagacaaca ctctcgtcgt ggcaacggat 2664001 tcaatgaaaa actttatcca gcgccatctc gcatcctatg aaggaacgac aaccgagggg 2664061 ttcctacact atgtagctca ccgattttta gatacctatt ctcatatgga cacgatcact 2664121 ctgactggcg aagacattcc gtttgaagca atgcctgcat acgaggagaa agagctcagc 2664181 acaagccgcc tcgtcttcag aagatcgcgt aatgaacgaa gccgctctgt gctgaaagca 2664241 gaacgaagcg ggaataccat aacgattaca gagcaataca gcgaaatcat ggatcttcag 2664301 ctcgtcaagg tgagcggcaa ctccttcgtc ggcttcatcc gggacgaata tacgactctc 2664361 ccggaagacg gcaaccgccc gctgtttgtc tatttaaaca tcagctggca atatgaaaat 2664421 acaaatgact catacgcttc tgatccagca cgctacgttg cggctgaaca agtccgcgac 2664481 ttagcgagca ccgtttttca cgagctcgaa accccttcaa tccaaaacct aatctatcat 2664541 atcggctgca gaatattagc gaggttcccg cagctcactg atgtcagctt ccaatctcaa 2664601 aatcacacgt gggatacggt tgtcgaagaa atcccgggct caaaaggaaa agtctacacc 2664661 gaaccgcgcc cgccatacgg tttccaacat tttaccgtga caagagaaga cgccgagaaa 2664721 gaaaaacaga aagccgctga aaaatgtcgg agcctgaaag cctgatggga aaactgacaa 2664781 cccatatttt agatttaacc tgcggcaaac cagcggcgaa cgtaaaaatt ggattgaagc 2664841 ggctgggcga aagtattatg aaagaggtat acactaacaa tgacggcagg gtcgatgtcc 2664901 ctctgctggc tggtgaagag ctgatgtcag gagagtatgt gatggaattt catgcaggag 2664961 actattttgc gagtaaaaac atgaacgcag ccgatcagcc gtttttaacc atcgtcaccg 2665021 tccgttttca gctagcagat ccagatgcac attatcatat cccgctcttg ctgtcgccgt 2665081 ttggttatca ggtgtatagg gggagttaag aaggaagccc gcctcaccgg cgggcttctt 2665141 tttgcacttc aattaacttt tgatcctagg acagtacttg aagtgatccc cacacttagt 2665201 gaaacaacag ctagaataaa cattcaccta tatttttcag gataattgcc tacgagaaaa 2665261 ataccctgta gtcctttcat ttataaatcg aggtttcaaa ctaataagtc agctcttagc 2665321 agccgagctc ccttctccaa tcctataaac agaccgcgtt ttttctcgaa aaaatactct 2665381 gaagacaatt gctgcgtttt taatagtttt gataacgcgt tctctcttac acctttagac 2665441 aaaatattca ttttttcttt tttagactta aatctatgtc gaaaataatc gttggcatat 2665501 cttatcctat ctccactaaa ggaggtgaca ttatgggatt ctacaattct ggtggataca 2665561 gtggaaactc tggttactca aacggtttcg ggagctcctt cgctttgatc gtggtgctat 2665621 tcattttgtt gatcattgtt ggagcagcta tctttaatta ttaagtttaa ctttccttgc 2665681 ctccgccgta tccaacacct ccctgtccga cagacgccat aagaagtttt tatggcgtct 2665741 ttgctatgtg ttcactaatc tttttgtaat ccagaagctg tcaagttcta cgagatttat 2665801 cgtgtgtttt cccacaacgc ttctgcgtct tgatcgcgct gtctgactga ggctaaaaaa 2665861 gtccggcttt taaaagccgg actcccgtct acccccgttc aactctcttc taatcctgca 2665921 agctgaccgc ataatcccgc catacccggt acaccggcac aaattccccg ccagcccttc 2665981 ttctatatct ttgtcagaag gttgaggggt ttcccgaaac aatgctttaa gcgcaatgat 2666041 cattcccggc gtacagtagc cgcattggaa gccgccttct tccaggaaag cggtttgaca 2666101 catatccagc tcttcttttt gaagcccctc gatggttgtg atggaatggc cgtctgcttg 2666161 ataggccatc gtcatgcacg cattggccag ttttccgtcg attaaaatag agcaggctcc 2666221 gcagcggccg attccgcagg acacctttgt cccggtcagc tgaaattcct ttctaagcag 2666281 gtcactcaga tgtgtcgtag gaacggcagc aacctcccac gcctgaccat tcacggtcat 2666341 ccggaactgt tcctttttta caggaaatgg cccggcctct tttatgtcca ttgcttcagc 2666401 ccctttctgt cgatcgcttc aagcaactct tctcttgaaa ttggcagctt gtttatccag 2666461 catccgaccg catcatgtac tgcctttaca atcgccggag tgatggcgat tgttccgatt 2666521 tcaccaacac cgcgcggtcc atatacgtct cccttcatta agtcttctat tgcaatcagc 2666581 ttcatgtcag gaacatcttt gattccggga atcaaatagt gatcgagatt ttccgcagca 2666641 taacggccat ccgtcatttt cgcttcctcc atcagtgtgt agccgagtgc catggcagcg 2666701 ccgccttcaa tttgacctcg atatccctgc ggactgacaa ccggacctgc cgcaatagcg 2666761 tgctcacaat ctatcaattt gacatcgcct gttaacagat ctacctccac ctcaacggca 2666821 gccgctccaa atgagtagag gaaatggccg cccaccacag gatcaggcgt tgttggaaag 2666881 tcaaaggccg tttcctctgc caaagggcct ttttcagcca gctccttata cgtcaccacg 2666941 agcgcctttg tgtttttgtc acgcaagcct gcagcgccgg gaataagatt ttccgctgaa 2667001 cagccgctcc attctgccgc ccgttttttc aactgagcta gaaacggctt cttcaaacgc 2667061 tggatcgcgt gccacaccat gcttgtgccg cgggatgctg tggaggagcc tgacttcggc 2667121 acttttgcgg tatccccaat aacaatggaa atatcctctg cggcacaacc cagctcctcc 2667181 atgacaatct gttcaatcgc tgctagaatc ccctgtccgc attcttcaaa tccaaacgaa 2667241 gcagtgattt tgccttcact cgaaagagac aaacggcctc ctgccgcatc cattcggcca 2667301 aaccccagcc cgccgccgtg cattgtaatt gccgctcccg tgcctctttg cagatacccg 2667361 cagttccggc ttgttttttt aagaatggga gatttagata tggcattcaa cacctgtgcc 2667421 gctccgtcag ttggtgcaat tcgatgctca agcggcccca agtcatgcgg ttttctgata 2667481 ttttttcttc tcagctcgag cgggtcgatg ccaagcatgc cgctgagacg atcgagatgg 2667541 gtttcgagtg caaatgtgat ttggttgccg ccaaagcccc gaaattcccc cgccaccccg 2667601 ttgttcgtaa atactgatat tccttcagtc cggatattcg gaatacggta cggccccgcg 2667661 gcatgctcga cagaaaaatc aagaacagcc ggtccgagcg tagcgtaagc gcctgtgtcc 2667721 gccacaattt tcacgtcgtg cgccaataga tttcccgaat gatctgcacc cgtttttatc 2667781 gtaatcttca tcggatggcg cttaatgcca gaacgtacag attcctttcg tgtctgatga 2667841 attttgacag ggcgtccgct tttcagggcc aaaagcgcag catacggctg aatattcagc 2667901 tcatccttcc ctccgaacga gccgcccatc ggacttgaca caattctgat cttctcttca 2667961 ggaatatcaa aaatacgggc aagctggaaa cggtctttat agccgtgctg ggttcctgca 2668021 tacatcgtaa aacccccgtc gtcttccgga acggctacac ctccctccgt ttccatatac 2668081 gtatgcatct gccgcggcag ctcataggtt tcttcaaaga ctgtgtcaga tgcttgaaac 2668141 ccttcttcca catcaccgtt tgaaaaaaat gcgcggtgca ggatattccc gtcctcatgc 2668201 agtctttgcg cattcggccg aagcgctttt tctggtgaat ccatgacttc cagctcttta 2668261 tactcaactt gaatcagctc cagcgccgct tccgcgattt cttccgtttc cgcagcaact 2668321 gcggcgatcg catccccgac ataccgcacc ctgtcctcac ataaaaccgg ctgatcaggg 2668381 atgacaatgc caaatcggtt taagccggga acgtctttat gtgtgacgac ggcctgcacg 2668441 ccttccattt tctcagcttt tatggtgcaa accgacacaa tctctgcatg aggataagca 2668501 cttctcagca ccttgccata cagcattcct ggaaagctga gatcggtcat atatttcaat 2668561 tcccctgtga ccttacccct tccatccggc ctgactcttg acggtttgtt gatgatcatt 2668621 tattcccctc cctcagccat cagctctgcc atgatgacgt tggcagcggc tttttttctg 2668681 tatgccgctg acataaaaac atctgaggaa aacggcagct catggataag tgttttgtac 2668741 agctcatgcg ggtcccaccc tggtgccatc catttcgctt cgctgtccaa taatctccta 2668801 ggagtgatat cggcatggcc agcggcgagg cgaatgctgc cgtctttcaa aaaacgtcca 2668861 gctgcaacag cagccgctcc ggtaaaagcc tggcgccttc caagcttgtg ataaaataca 2668921 cgctctccct ccgcccgcgg gatgatgaca cgcgtgacga tagccgttct aaagtcttcc 2668981 tcactgagcc aagcgccaag cggcagcctg attagctcct tttgatatac gataagctca 2669041 gcaccaagca caagcagaag cggaatgaaa tcaccgattt tactcgctat gttgccgcca 2669101 atcgtggcac ggctgcgaat ccccggtgca gcgacagcgg aagcagcgtc actgaaacag 2669161 ctaagcgctc tcttaatcaa agggttcttt ctgcattcat tcagtgatgt gagccccccg 2669221 atcgacacgt gggtgtcact ggtgctgatc cctcgcattt cgtcaatccc ttcaaggctg 2669281 acaaggtgct gtttcggtag agttcctttg tcccactgaa gctgaaggag cgtgcttccc 2669341 gatgcggcac acacatccgg agcaagcttc tctaaaagcg aataggcctc atcaagcgct 2669401 gccggtctcc ataattgaat attcatcctt gcttttgtca cttggccgtt caagacatcg 2669461 ccctccttac catgtcatat tcctcgggtg tatcaatatc gtccaactca ccgctatcct 2669521 ttgcctccaa aaccgctcct gctccaagct gtccgctttt caggagcctg cgagcccctt 2669581 catctccctt taatcccttt acataaggaa aacatgtcga cgagaagtag attggcgggg 2669641 tgaacgcccc taaaaacgat gacacggcaa atgactcagg agccagagcc acaagggcat 2669701 tgagatgatc gacggaaagc tgaggctggt cggctaacaa aatgacaatg ccgtccgccc 2669761 ccatgctttc tgcttttctc accccgctgc tgactgaatg cccctgaccc ttttctgcgt 2669821 cttggcaaac gtgcaggctc cagcgttttt gaaaaggcgg agcgtgatac ggcgctccta 2669881 tccactcaag ggaggcatgt tctgtccgct cgacgaccag cacgtgatca aggcgggacg 2669941 acagagcagt tttcaaggaa agtgagccta tgttttctcc ttttagcggc aaagccagct 2670001 tgttttgtcc cattcttctg cttttgccgg cagcgagaaa cacgccgatc agataggggc 2670061 ttctcataca accgccaccc gttttcttgt ttgaatgatt tctgcaacta cacttaccgc 2670121 aatttcctcg ggaccttccg caccgatttt cagcccgacc ggactgtaaa agtgagacgg 2670181 aggatgtttt ccgctcagca gccgtttcgt gcggtttgcc gaacccaaca gtccaatata 2670241 atggaggttt tgagaaaata agaagttgat gatcgtttga tcgtgctgat aatgatgggt 2670301 tgccacaaca gctgcatcat gcggaaaaaa ttgaaattcg ctaagcattt gttccggaaa 2670361 agcggtgatc agctgatccg cttttggaaa aagagaggat gtacaataag cgggccgcca 2670421 atccgtcacg ataacagaaa accctgtgtc agccgccaaa ttggccagcg gtacattatc 2670481 cggtcccgcc ccaaacagaa tgagacgcgg cttcggttca attcgctgaa taaacatgtt 2670541 agtggtttga tcgaaatgcg gtaaatgaag cgttgaaaca gtacgttgaa tatcttgcag 2670601 aggcgcgtcc ggccagttcc caaaatgtcc gttctccgtc agaaataaat aatgggagga 2670661 ttcaatcttt ataacggaag tgacagcttt gcctgaatga aggcagtccc tcactttctc 2670721 atagtgccgc cttttttcct gagtgattcg ctctgcatga acatgaataa tgccattgca 2670781 cccggctccc atgccccaag aaagatcgtc ctccgaccgc atgtcgtagg gaatcagcgt 2670841 tgatgtgagc tgatcgccca gcgcactgat tctttggaat acatcttctt ccacacaccc 2670901 gccgctcagc aagccaatcc gtctgccttt tttcttaaag agcatagagg cgcctgcttt 2670961 tcgatacgcg gagccttcaa cttgaacaat tgtcgccagt acagcctcct cctggtcttc 2671021 caggagcgca tctaacatcg tgtgaaaatt ccccaatgcc gcatcctcct ctcgaaaatt 2671081 gccgtgagaa acaactagtt cagcgtgatt ttataggtaa cttgtataaa gaatagacga 2671141 tggaagaaaa aatgactcat gatttgtcag aaaatgaaac acatagaaag aggatttgta 2671201 aaaagagtca aacgaagaaa atcagattgg agaaaacacg aaatcatatc gttaaaaagc 2671261 ttgcggagtt ccgcaagctt ttctttacac cgctgcctgg cggccagcgt tttcatacac 2671321 atccagcgct gcttggagcg cttttcctgc ttcgattcct gcgttatgtc tgagaagcac 2671381 agcctctaac ccggcaagca cgaatagcac gttttctttt ctgcagctgt accccatcgt 2671441 gccgatcctc cagatcttcc ctgcaagcgg gccgaatgag ctggcgattt caatgccgaa 2671501 ttgtgccagc agcatgtcac ggacagactc gccgtcaatg ccgccgggaa tttcgacaca 2671561 ggtgacaaca ggcattttgc agctgtcatc tccaaacaat cttagcccca ttgcctttat 2671621 ccctgctgct aatgcggctt catggtgccg atgccgctcg aaacgcgtct caagaccttc 2671681 ttcaagcacc agtctgactc cctcacgtaa ggcgtacagc atcgtcgtcg cttctgtatg 2671741 atgattgagc cgtctttcgc tccaataatc ctcaagctgg ctcaaatcaa agtagttgct 2671801 tgtaattggc cgatttcccg aaagtgctgc cctgtcagct tgtgtcgcaa tcccgcgttc 2671861 cacctttttg cgagctgcaa tcacgtccgc cacccgctca ttatatgtaa tcggcgccat 2671921 tcctgaaggc acagacaaac atttttgcgt tccgccgatg gcagcgtcaa tcttccattc 2671981 atcgacttta acctcgcagc ccccaatcgt tgcgactgca tcgacgataa acaatgcatc 2672041 ctcggtgcgg caggcttcgc cgatggcttt cagcgggtga atccgtcctg tcgatgtttc 2672101 tccatgcacc atggccacaa ttttcggctt cacttttttt atctcccgta tgatgtcctc 2672161 cgggtcaaaa accgttcccc attcgcactc cagcatatga acatttgccc catatcgctc 2672221 ggcgatttca gtcagcaaat aaccgaaacg gccgtaaatg ggaatgagca catcatcttc 2672281 cggctctatc acactagcca gcactgcttc aattcccgcc cgtgaagtgc cgtcaatcgg 2672341 gtatgcccag cggttttttg tttggaacag ctcccgaagc atctccatcg tttcattcat 2672401 aatacctgta aacgccggat caaattggcc gacaaccggg gtgctcatta ctcttaatac 2672461 acgcggatca acctcaacag gccccggtgt cataatcgtt cttaacgggg tgcataattc 2672521 tcttctgcct gacacagcca ttcctccttt atcagtaagc cagtttgtat aataaatcag 2672581 tcagtgcgcg gacgccgatc tcaagctgtc tggctgacgt atattccttc ggtgagtggc 2672641 tgacgccgcc tcggctcggc acaaacagca tacaagcagg atagcgcctt ccgatcattt 2672701 gcgcgtcatg ccctgctccg ctcaccattt cctcacagct gaagccgttt tctaatgctg 2672761 tttcaaaagc cgcagccttc agcctttcgt ccatcggcac aggctctatc cgcatatatt 2672821 catcaatcac agcgcgaatt cctttttgta ggcaaatgcc gttgatcaaa gcaaccatgt 2672881 cttgatgaaa ctgttccagc acatgctgat gctgatggcg aatatcgatt gaaaactgga 2672941 cgcggcccgg tatgacattg gctacattgg gctctgccgt tatttttccg catgtcagac 2673001 ggagctcatc cggcagctca tccgaccgca gcagcagctc atgaatgata cggctgctgg 2673061 ctgcgagcgg gtccttgcgc catttcatgg aggtggttcc tgcgtgattg cattctcctt 2673121 cgagcgtgac gagatatcgt ctctgccccg caatacttgt cacgatgccg agatcccggc 2673181 ctgacatttc caacgtcttc ccctgttcaa tatgcagctc aacaaacgcg ctgatatctg 2673241 tcctatatgc tgactgaaac acacctttgc caaaaccgct ctcatgcatc gctgtttgga 2673301 gggagactcc cgactcgtct cttggctctt ttgcatcttg ttctgaaaaa acacccgtca 2673361 tattccccga cccccaatag gtcattggaa aacggctgcc ttcctcctca cataaggaga 2673421 ccgcctcgag cgtttttttt ggcgctccgt atgtttcctt gagctgcttt aacgcgagca 2673481 ttgccgccag aacgccatag gcgccgtcgt attttcctcc attgatgaca gtatcgatat 2673541 gtgaaccggt tacaatgact tcatccggag actgggtgcc cgaaagcctt ccaaacacat 2673601 tgccgacatc gtcgaatctt gtttcaagcc cgaaagaaga catttccgtt ttcacagcaa 2673661 gctgtgcgtc catccactct tttgtgtata aaagcctcgt tacgccgcca tccgcagacg 2673721 caccgtattg ggcgagccat tcaatataat ctgtgatgct gttttttact gaaagcttct 2673781 gcttttccat gtactccccc ctctggccgc tatggtgact tcattataga aggagcaaca 2673841 tgatagttca ttgacagatt aaccaaaaaa acgtttattt tttagccaca gtatccatcc 2673901 agcaaccaga tacaccctac atgtcacaac tattttgatg taaaggtcaa aagaaaacac 2673961 ggtaaggaag agagccagca agagcgaaag agagggtcaa aatgcctttc atatgaacaa 2674021 gctaagctgg agaggcgatg ttcgcggaac ggatgaaaac agaaatgccg gcagcccgca 2674081 aaaacaggac ctaaagatat ggaaacagga gatttccgcc tcctccaaag ggactaattt 2674141 acaattttaa tgaaaaatat acaaaatgac acttctatcc tttatttcaa ttttagataa 2674201 tagatatgat ctgataaaag gagggcaagt gatgacaaaa aaagcatggt ttctgccgct 2674261 cgtctgtgta ttactgattt ccggatggct tgcgccagca gcttcagcaa gcgcgcaaac 2674321 cacattaagc cttaatgacc gattggcgtc ttccccttca ggaacgggaa gccttctctc 2674381 attagccgcc cccgctgcac cctatgctga cacagatacc tattatgaag gggctgaagg 2674441 taaaacagga gactcgctaa aaagcaccct gcaccgtatt atcagcggac acacgatgct 2674501 gtcctacagc gaagtgtgga acgcgctgaa agaaacggat gaagacccaa gaaatccgaa 2674561 taacgtcatc ctgctctata cgaatgaatc gcgttccaaa aacctgaacg gcggcaatgt 2674621 cggcgattgg aaccgcgagc atgtctgggc gaaatcccat ggcgattttg gtacgagcaa 2674681 gggacctggt actgatattc atcatttgcg cccggctgat gttcaagtta acagcgccag 2674741 aggaaatatg gattttgaca atggcggcac tgaatatgcg aaggcacccg gaaattatta 2674801 tgacggcgat tcatgggagc cccgcgatga tgtgaaaggc gatgttgccc gcatgctgtt 2674861 ttacatggct gtccgttacg agggtgatga cggctatcct gatcttgagc ttaatgataa 2674921 gacaggcaac ggctcagctc cttatcatgg caaacaatct gtcctgctcg aatggaataa 2674981 gcaggatccg gttgacgacc gcgagcggaa aagaaatgaa atcatttatg aaaaatatca 2675041 gcacaaccgc aatccattta tcgaccaccc tgaatgggcg gatgagattt ggccgtaaga 2675101 aaaaggtgct ccttttgagg agcacctttt tctaatacac agcctcttcc gtttccgcat 2675161 cgaaaaagac gacgtggtcc attttcactg agagctggat tgaatcgcct gcatcgattc 2675221 gcgtgtttcc gtccaggcgg accttgagcc gctcgtcccc agccatgaca tgcactatga 2675281 gctccgagcc cagattttca ttcacttcca cgttcgcttg aaacactgaa tcaaacaact 2675341 ggtcatttcc tgtcatttgt gtgatgtgct ccggccgtac accggcaatc atctgttctc 2675401 cggcatatcc cttttccttc agccgctttg ctttttcttc aggaatatga agccggatcg 2675461 aagaatttgt gaaaaacagc tcgccatgct gctgttctat gatgcctttc aaaaagttca 2675521 ttccgggaga gccaatgaag cctgcgacaa acaaattggc cgggtaatga taaatgtcat 2675581 gaggtttcgc cacttgctga atttcccctt cattcatgac gacaatccga tctcccattg 2675641 tcattgcttc ggtctggtca tgcgtgacat aaatgatcgt tgcctctaat cgctggtgca 2675701 gcttgctgat ttctgtccgc atcgtcactc ttagttttgc atccagatta gaaagcggct 2675761 cgtccattaa aaagaccttc ggctccctca caatcgacct gccaagcgcc accctttgcc 2675821 gctgcccgcc ggagagcgcc ttcggttttc tcttcagcaa atgttcaatt tctaaaattc 2675881 tggctgccgc atgaacccgc tcggcaattt cctgtttcgc catctttctg agctttaatc 2675941 caaacgccat attatcaaaa accgtcatat gcggataaag cgcatagttc tggaatacca 2676001 tcgcaatatc acgttctttc ggcggaagat cattgacccg ctccccatca ataagaagat 2676061 ttccttcaga aatgctttct aatccagcca ccatccgcag cgttgttgat tttccgcatc 2676121 ctgacggccc caccagcacc aaaagctcct tatcctttac atctaaatca aagtccttca 2676181 cggttaattg tgagtgatat gattttttga cgtgttcaaa tgttaatgaa gccatcagaa 2676241 aagtccccct atcttttgac ccgttatttc gtcactggaa acaacttggt ctttctgtta 2676301 tttttagagt aatcgattcc catttttgct atatttctaa aataaaaaat gtaaatttgt 2676361 attataacgt cataatacat tataatataa ataataggtt aaaaggaggc taccctttgt 2676421 taaacaacgg aagttctaca cctttataca ttcagctaaa acaaatcatc actgatgaca 2676481 tcaaaaaggg cgtgtattcc ccaaccgcca agctgcctac cgaaaacgag ctttgcacca 2676541 agtataacgt cagccgcatc accgtcagga aagccattct cgatttagtc gaagaaggct 2676601 atctgatcag gcagcaggga aagggaacgt tcgttaaaag ccctaaatta aaacgagagc 2676661 tgatcgctgt aaacggctac tcggaattta tggaatcaac cggcaaaaaa ccgaagcatc 2676721 atgtgctgtc ccatgacatc attccagcgt caaaacccat cgccgaaaag cttcaaatcc 2676781 aacccgagag ccctgtggtt gaattaaaac ggattttata taatgatgat cagcctctca 2676841 cctttgaagt gacgcattat ccgcttgatt tgtttcccgg cattgatacc tttattgctg 2676901 acggcgtctc catgcatgat attttgaaac agcaatacaa agttgtaccc acgcacaata 2676961 cgaagctatt aaacgttgta tatgcccaac aggaggaaag caaatacctg gattgtgata 2677021 tcggggatgc gctgtttgaa attgataaaa cggcttttac atcaaacgac cagccaatct 2677081 attgctcatt gtttttgatg cacacaaacc gtgtcacttt taccatcaac agcccctaca 2677141 cataacaggc ataaaaaacg agacactgct tatagtattc tcgttttttc actgcttccc 2677201 ccgtcctcca agcgataagg atagccatag ccgaaagctc cgtacacacc gcaagttttc 2677261 gcagccgttt cagcagcctg gcgcaaagca tacgttatat cctgcttcac gcaaaaggca 2677321 gtcaaaaagc ctgctataaa agaatctccc gctccaagtg tatctattat atcagcttcc 2677381 acaatcggct gatgatagac tcgatcaccc gcagacagga ttgctccttg gccccctcgg 2677441 gtcatacaaa ccattttggc tccgtaccca tgagctgttt tggcaagctc accgcattcc 2677501 gactcactca aatcgcttcc tgaaaaaaac gcatacgtca cataaggaca gaccctcctc 2677561 aaataatcat cctcccgatt ggttgaaaaa tcaaatgaga ccgggaccag cccgcacagc 2677621 tgcggaagat cgttctcaag cctgctgtac acgctcgtat gcagcagatc atgcccgctg 2677681 ataaaagata catctttctc ctgaaacgcg aggcgaagcc gggactgaat gccgccttta 2677741 tttgatctga caaaaatgcg gtccccctgt tcatcaaggg tgacaatcgc catcccgttt 2677801 tctccgtgcg cctggcggat ataatctgca ttgacctgct ccagcttgag aacgttcaac 2677861 agatgcgccg cggcttcgtc attgccgacg attccgatat aggaagactc atgcccgagc 2677921 cgcttggcaa gcacagcaac gtttaaggca tttcctcccg ggtaaaatgt ttcttgatcc 2677981 tggtagtaat ctacaacatt atctccaacc gcaatcaatt tcatagcgct tcctccttta 2678041 tccttttaca ctgccgcttg caatcccgcg gacaaaatat ttctgcatca ataaaaatag 2678101 aataataatc ggcgcggctg aaatcgttaa ccccgccagc aggacgcccc agtctgtctg 2678161 cagcgcgtct ctgaactgca tcagcccggc tggaatggtc cgtaaattct catcatctat 2678221 gaaaataatc gcaaacataa actcattcca tgtatggtaa gccgtcaaaa tgccggatgt 2678281 caccaaaatc ggcacgctca ttggtaagaa aattctgaaa aatactccaa aacttgtaca 2678341 cccatccaaa taggccgcct cctccaattc ttttgaaata gaaagaaaat aagagcggat 2678401 caaaatgatg gtgaatggga tccgataagc cgcatacggc aagattaacg cccaatacgt 2678461 attgtacagg cccagcgact gaataataga ataaagcggc acaagactga cctgcggcgt 2678521 cagcatcaat ccgccaagac atagcaccaa aaagaatcct tttcctttaa actcaaaccg 2678581 ggaaaggcca tacgctgccc atgcactgat aaagacagtg atcacacacg tcagcgccgt 2678641 aacgatgaca ctgttcataa aataagaaga aatcccctga ttccaggcgg aaacaaaatt 2678701 ttccggatgc cacgaagacg gcagcgacca gctgtgctca aaaatatcgt cagagttttt 2678761 aaaggcgctc atcaccatcc agagaagcgg ataggcaatc gcaatcagat aaagaaacag 2678821 aaaaacccac acagacgttt ctccgatata ccattttcgt ctaggcttat ctttcacctc 2678881 aatgtgctgg tcaggcaccg gctccaatct gaacgaatct gtcttcttct gaggcagcat 2678941 cagttactcc tcctttccgg ttttaaagaa cttcatttgc atgagcgata atgcaagcgt 2679001 aatgattaac acgacagtgg caatcgctga ggcgtagccc atcatatcct ttgtaaaggc 2679061 gcttttatat aaaaacgtgc tcaagacttc tgacgctttt cccggcccgc cgcctgtcaa 2679121 aatgtacggc tcattaaaga ccgtaaaggc tccggtcagc gtcatgacca ccgcaacaaa 2679181 agacatctct ttcgtctggg gaacagtaat atgaaaaaac tgctgaattt tacccgcgcc 2679241 gtcaagccgg gccgcttcat acagttcatc cggtattttt tgaatcgaca cgatgtacag 2679301 catcgcaata taaccgacag attgccactg ggacacaaaa atgacagaaa gcatagctgt 2679361 gctgtcatcc ccgagccagg ccctcgtcag ctgatcaaga ccgatggcct gaagcagctg 2679421 attcaaaagc cctgtctccg gattgtaaat aaaatcaaac aaaagcgcga tcaccgtcat 2679481 tgagatgaca accggcaaaa agaaaacggt acgaaaaaac ggcgaccatt ttctgaccag 2679541 cttatcctca agcaccgccg ccaaaatcaa accgccaaat acctggcata caattgagat 2679601 cactgcataa agcacattat tggtaagtgc ctgatagaag acaggatcat gaaataattc 2679661 aacatagttt tttaagccga taaacgtttt ttccggagaa aatgagctcc actgaaacag 2679721 gctgaggaat acattctcaa aaatcgggat ataaacgaaa agtaaaaaaa cgagagcggg 2679781 caccaaaaac aaatagggga ttattttatt ctgattgacc aagggtatct catctccttt 2679841 ataaaaagaa aaggtgcgaa gcttcacctt ttctttgatt tattcagctg acgccctcac 2679901 ctgctttgct gccttttgaa cggctttcat cacctgctgc ggtgtcatgt cgccgccaag 2679961 catttgctgg acgcccgtta ggtacgcatc tgcgacttca acatcgacat ccatatcaaa 2680021 ccatggaacc attgatttgg catcaacaat atgctgaacg gcttcacgct gaatggctgt 2680081 tgcattttct tcagtagccg taccttgcac tgcactgtat ttcccgacat ctttcacgag 2680141 cttttcgccc attcttttcg acgtcaagaa ctgcaaaaat tccatcgctt ccttcggatg 2680201 ttttgttctt gaggagatca tgaatccttc cggcgctccc gttaacgctt ctgaagatcc 2680261 tttctgcccg ctgatttcag gaaatgggaa catcccgaga ttaaccggtt caaccagctt 2680321 gatttccgct gtttccgcat atatcatcgc cgactttccg ctcttaaatt gctgtctcac 2680381 atattcgtgg tcgacggagt ttacatgttt attaaagtaa ggcatcagct cttgaagctt 2680441 ttcaagtgct tttacgtagc cttcatcagt aaattcaccc gttttggcgt tatagtcctt 2680501 ttcccgtgtt ttttcatcga ccatccgctg attaagcgtg ccgatatagt gcgagattgt 2680561 ccaagtcgcc tttgttccaa agctgatcgg tgtgtagcca tgttctttca gcttttttga 2680621 cacatcgatt aattcatccc acgtcttcgg gggatcaaga ttcagctttt ggaaaatgtc 2680681 tttattatag aagaatgatt tagcgtccat ttgccacggt acgccatatt gcttgttttc 2680741 ataagtaaat ggtgtaattt gcgattgaac gagctgtgat gaccaatcgg tgtcattttt 2680801 gtagtaggac gagagatcaa gtgctttatt gcctctgata aatttaaaag caaactcatc 2680861 gctccaagag aagtaaatgt caggagggct ggtggttccc agcatgacct taattttatc 2680921 tttataggag tcatttaaaa cggcttcaat ttgaatgtcg atatctgggt gatctttttc 2680981 aaattcctta acaacctctt caaaataact tttttccggc tcctttggcc atctgtggaa 2681041 aaatttcaat gtcacctttc cgtccgctga actgctttgg ctcgaacagc ctgcgatggt 2681101 gagcatactg acagctgcaa tgatcaagaa caacaacatt ttcttcaaag ggttggcctc 2681161 ctctggacat tagactataa tgttatataa cattatagtc taatgcataa tggttcttca 2681221 ttttcagatc aatactcaac tttccacatg tatcttctat gagataaagg atgatttctc 2681281 tcctctgcca gctcgtctgc atagcttctc agcacacgat tgagaacgag cggagcaaga 2681341 tagcctttaa ctgaatcgtc aattgcagtg aagtcgtaag atgcagcatc aagcacagtg 2681401 agctttttgc catacttttt cgagaaggta agcgcccgct cttcaagagg tcttgtttca 2681461 tctaaaccga gcaggatgat aaacggcacg gattcatcaa taatttcaaa cggtccgtga 2681521 aaatattctc cggcatgaat ggcgtgggaa tgaatccatt gcatttccat gagaatgcag 2681581 atgctgtagg agtaagcgac accgtagttt gcaccgcttg ccatggtata aataatgctt 2681641 tctttttcat gggcttttgc aaattgcttg gcgttgtcag cttcctgctt aagggctttt 2681701 tcatatacag cctgcaattg atctaagcct tcaattgctt gctcaaattt cgtattgttt 2681761 tctaatactt gcagggttcc aaaaacgatt tgatacaaaa cgccatagtt tgtattgatc 2681821 gcaagcgcct catcacccca atcgtactgg gcaacatatt gcgcttcctg cgctaaagga 2681881 gactccggtt taaacgtcat cgcaatcgta agtgcgccct tgccccttgc aaacgcagca 2681941 gctttgactg tctccggggt atttcccgaa tgcgagcaca aaataacaag agacttttca 2682001 ccaagctgaa cagggttgcg ctgaataaat tcgttggcgc tgtagagatc ggagtttatt 2682061 gattttgact ctctgtcaaa cacatactta ctcggataca taatggcaga agaccctccg 2682121 catgcgacaa agaatacatg atcaatggtt ttccctttca aatcctgcaa gaaagcttga 2682181 acctcacgat ttacttttgc tgtggcctga ctcaaatcct tcactcctcg tttttattat 2682241 ataacgttat ataacattat atattgttat attaaagtcc gcgggtagga ttgtcaatat 2682301 tattttctga aatttctcaa taatttattc ggatgacaga caaagggtct atatgcgaaa 2682361 aaatgcccaa atcaaaagcc agaacttgac ttaagctctg gcttcgctgt tcaatccgca 2682421 gactgacgtc ttatttaaaa aataccttgt ctatattgta cttcgagtgc tgtgtattga 2682481 tgatatatgt ttcgtaaatc tctctttcca ttggatcatc aactacacat acctcaattt 2682541 tataaacttc atctctgtga tgtttgatcg gtgaaacagt gtcttcgaaa tgcttcttaa 2682601 ttctctgtct taactttctg gctttaccga caaacagcag ctcgtcatga atgttgtaaa 2682661 acataaaaat gccgcctttg tcccttggga tctggtgaaa gtcgatgaat ccgtgaatcg 2682721 gttttatctt cggctcgtta tcattagctg actgctgtcg ttcagtgatg gtgacattcg 2682781 gtgcgggtat atcaattttt atcaaaatca gttcacgtcc tctttttcat taaagataaa 2682841 tgctaacaca tacagaaaag aaaagctaga acagctttat tatatttgtt tgtcatgctc 2682901 ttacttatta tgcaagtgct ccggctggat cataaggact aaggtctaat tctgtctgct 2682961 ttccgagaac tagctttgcg agctctgcac ccaaaaacgg ccccatcgtc agtccagaag 2683021 cacccaaacc gtttgcagcg tacaggcctt gaacattcgg cacggcccct acgaccggca 2683081 gaaatcccgg tgtaaacggc ctgaagccca ctcttgtttc aacagcagcc gcatcagcaa 2683141 gacccggtgc aacggctaac gctttgctca atacttcgtg ctggcctccg gctgtcacac 2683201 gaagatcatc aagaccggca tcgttttcgt gtgtggcgcc ggctacaatt ctgccgttat 2683261 caaacgacag aatgtactga tcactcggcg gcattacaac cggccacgat cctgtatctg 2683321 catctgtcat ttcaaaatgc ataatctgcg ctttttgaaa tgacacttga aaatgaatgc 2683381 caagaggctt caatatctca ttggcccatg ctcccgccgt cacaatgacc gcgtcagccg 2683441 caaactgctt tgtatctgtt tgcacgccgg tgactgttcc gttttcaaaa agcaaggacg 2683501 catttccttt gatgaccgtt gcgccgcgtt tctctgcagc gcttaaaagc gaccggcaca 2683561 gcgctcttcc gttcacacgg gcggcaccgc tgatatgaac cgattcatag ccgtcagcta 2683621 aaatcggaaa cagctttttc gtttcacttg cagacaagcg ggtaatgtcg ccgatttccg 2683681 gcgcatcctc ccgtctctta tacgcccttt cctccatttt atcgagttta gacgcgtcag 2683741 tatgaatgct gatggcaccg acacgtttgt atcctgtatc cgattcaccg tctttttcca 2683801 attgatggat taaatcctta tagtaccgcg ctcccccctt agcaagctgg taccaatcct 2683861 gattacggcg ctgcgagagc caaggacaga cgatccccgc cgccgcatca gtcgcttgtc 2683921 ccggctcttt ccgatcaatg acagtaacgc gagcgcctgt ttttgcgaga tgataagccg 2683981 tcgacgcgcc cagaatccct gcgccgacga tgatgtacga tttcatatgc aaacaccttt 2684041 tctattataa tgtctattca ttttaccaaa tcaaatgctt tccttcgacc ttttgcccta 2684101 atgtggaaaa accgcgaagt tcgtccaatc tctttactct cctatcgaat atcctgtcac 2684161 tatcaataga gaaaggatga taccatgagc gaaaatcgtc atgaaaatga agaaaacaga 2684221 cgcgatgcgg cagtggcaaa agtccaaaac agcggtaatg caaaagtcgt ggtcagcgtg 2684281 aacacagatc aggatcaggc acaggcgcag tcacaagacg gagaagacta atgaacgaaa 2684341 acatcattcc tcttaacaga catactcaag agatacccac tactgaatct gttatcaaaa 2684401 acagcggcaa ctcagaggtc catatcgaca ttcacattga tacaatgcca attgcttttg 2684461 ctatattatg ctctgcatta gccgcaaagc agatgacaaa agaggaattc gatatggctt 2684521 atactcaatt gcgagagatg aacagagaaa ataacagcag atcatctgta aagcaaatta 2684581 tcaatcaaga gacagaagaa gagtaaaaaa ccgcggcccc tcggccagcg gtttttcttc 2684641 tgcatacaaa aaggacgcga ctgaatcggt tacttctgta caatttgaat aaggttaccg 2684701 catgtatcgt cgaagacagc tattgtgact tcgcccattt ttgtcggttc cgtcgtaaac 2684761 gtcacgcctt tttcctttaa tcggttgtac tctttttgaa tatctgcaac gccaaacatt 2684821 gtggccggga ggccttcgga gaatatcttc ttttgatact ccttggcggc aggatgttca 2684881 ttcggttcga gtaaaagctc ggttccgtct tgatcatctg gagaaacaag cgttatccac 2684941 ctgaatttcc ccatgggaac gtcttccttt tttataaacc caagtttttc tgtataaaac 2685001 tccagtgcca tgtcttgatc ttgtacaaat atactggtaa caacgatttt catactgttt 2685061 ttccctcctt cgatatgaat gaagcatggt actatgctaa caatctggct acaagcaaaa 2685121 caacccacac atttatcaga ggccctgttc tgattttata aaattattct atccatcctt 2685181 tcagcaaatt tttaagcggt tcgttgttga atataagtac tcgatatttt ccctttcgtt 2685241 ttgatgttac gagtcctgca tcctccagta cagaaaggtg tttagctatc gcctgtcgcg 2685301 taatagaaag gtcgtacttt gtaataagac gtatcgtaag ttcatacaac gtcagctcgt 2685361 tgcgttcaga taattcgtct aatataagcc gccgagtcga atcgccgagt gctttgaata 2685421 tagcgtcttt gttcccattc atatattgag tataagcaac ccattagttg catgtcaagt 2685481 ataagcaact gtatggttgc gtgatataga aactgaacct atccggcgca ggtctgaaat 2685541 attctaatcg ataaggaatt aaaaccatta aaataacagt ggatatgtct ctgaaaaata 2685601 aaagaagacg aacttcaaaa gttcgtcttc tacaatcaaa ttcggcacgc cggccatttt 2685661 aaagttgata actatctcta aaccccttga taaacaaagg agttttcatc attaaccgat 2685721 agaaccttcc atttcgaact taatcaaacg gttcatttca actgcgtatt ccatcggaag 2685781 ctcttttgtg aatggctcga taaagcccat tacgatcatt tcagttgctt cttcttcaga 2685841 aataccgcgg ctcatcaagt agaagagctg ctcttcagat actttagaca ctttcgcttc 2685901 gtgctccaat gaaatgttat catttaagat ttcattgtaa ggaattgtgt cagaagttga 2685961 tttgttatcc ataatgagcg tatcacactc gatgttagag cgggcgcctt ccgctttgcg 2686021 tccgaagtgg acgattccgc ggtacgttac ttttccgccc tgttttgaaa tcgattttga 2686081 tacgattgta gatgatgtgt ttggtgcaag gtgaatcatt ttcgcacctg catcctgatg 2686141 ctggccttta cccgcaagag cgatagaaag cgtcataccg cgcgcgcctt cgccttttag 2686201 gatacaagcc ggatatttca ttgtcagctt agaaccgatg ttgccgtcga tccattccat 2686261 tgttgcgttt tcttcacaga ctgtacgctt tgttacaagg ttgtaaacgt tgttcgccca 2686321 gttttggatc gttgtataac ggcagtagcc gccttttttc acgatgatct caacgaccgc 2686381 actgtgaagt gagtttgttg tgtaaacagg cgcagtacag ccttcaacat aatgaacgct 2686441 tgcttcttcg tcaacaatga tcagtgtacg ttcgaactga cccatgttct cagagttgat 2686501 acggaagtaa gcttgtagcg gtgtttcaac cttcacgcct ttaggcacgt agatgaaaga 2686561 accgccggac caaacagctg agttaagcgc cgcaaacttg ttatcagtcg gcgggattac 2686621 ttttgcccag tgctcacgga aaatatcttc attctctttc agcgcgctgt cagtgtcttt 2686681 aaagacgatg ccttgtgctt caagatcttc tttcatgttg tggtatacaa cctcagattc 2686741 gtactgagca gaaacacccg caaggtattt ttgttcagct tcaggaatac cgagcttgtc 2686801 gaatgtttgt ttaatttctt caggaacttc atcccaagaa cgctctgaac gctcagacgg 2686861 ttttacgtag tacgtaattt cgtcaaagtt cagtgagttt aaatctccgc cccattgagg 2686921 catcggcata ttgtagaaat gctcaagtga tttcaagcgg aagtcaagca tccattgagg 2686981 ctcttctttc atgcgagaaa tttcttctac gatttctttt gtcaatccgc gctctgaacg 2687041 gaaaatggaa acgtccttgt cgtgaaaacc atacttgtat tcaccaatat caggcatttt 2687101 tttagccatc cattttcact ccaatccttt taattgccgc cttcttcttt cgcgactcct 2687161 ttttcaagtg ctttccatga cagggttgca catttgatac gggcagggaa ttttgaaacg 2687221 ccttgaaggg cttcaatatc cccgagatct atagaatcat catactcttt cccttgcatc 2687281 atatccgaga aaatcttaga catggaaagg gcagtttcaa tatctttccc tttaatcgcc 2687341 tgagtcatca tcgaagcgga tgccattgaa atggaacagc cttccccttc aaacttcgca 2687401 tcttccacga tgtctccgtc aagcttcatt gtcagtctga tgcggtcgcc gcatgtcgga 2687461 ttgttcatat ccacgacaat gctgtcattt aaaacccctt tatttcgcgg gtttttgtaa 2687521 tgatccataa tcacctgtct gtacaatgta tctaagtttg cattaaaaga catttgtaaa 2687581 atactccttt gtcttttgaa gagcttccac aagcttatca atctcttcct ctgtattata 2687641 cagataaaag cttgctcttg cagtagcagt tacatccagc catttcatca gcggctgcgc 2687701 acaatggtgg ccggctctga ctgcgattcc ctccgcatca agcacagtcg ccacatcgtg 2687761 cggatgaaca tcatcaaggt taaatgtgac aagcccggca cgctcttccg gcccgtaaac 2687821 cgttacgccg tcaagctggc ggaagcgttc aagcgcataa gctgcaagct tgtgctcatg 2687881 gcgggaaatc tcatcaagac cgatttcttc gagaaaatca atggcggcac cgaggccgat 2687941 tgctcctgca ataatcggcg tacccgcttc gaatttccac ggaagctctt tccaagttga 2688001 ttcataaagc ccgacaaagt cgatcatttc accgccgaat tcggcaggct ccatgttttc 2688061 cagcagggct ttctttccgt acagcacacc aacaccggta ggtccgcaca ttttatggga 2688121 agaaagcgca aagaagtcgc aatcgagatc ctgcacgtca attttcatgt gaggcgtgct 2688181 ttgtgcaccg tccaccacaa tgacagcccc attgtcatga gcgattttcg ccatttcttt 2688241 aatcgggttg accgtgccga gaacattaga tacatgagac accgcaacaa tttttgtgtt 2688301 gcttgtgacc gtttctctga cgtcttctaa agaaatcgtt ccgtcttcct gcaacggaat 2688361 atattttaat gtggcgccag ttgcttttac agcctgctgc cacggaatga tattcgcatg 2688421 atgctccatg taggtgatga ccacttcatc accaggtttc aggttggcgc gcgcatagct 2688481 taacgccacc atattcagtg atgtggtcgt gccttttgtg aaaataatct cagccattga 2688541 cttcgcgtta ataaacttgc ggactttttc acgcgctcct tcataaccat ctgtcgctct 2688601 ggttccaagt gtatggacgc cccggtgaac attggaattg tattggttat aatacttatc 2688661 cagtgtttca atgacagcac gcggcttctg ggaagtcgcc gcgctgtcga gataaacgag 2688721 atcatgtccg ttcacttgct gatgaaggat cgggaactgt tcacgaatat ctgtgatatt 2688781 cattacttca ctttcctttc gataacagaa actaattgtt tcttaacgcc ttcaatcgga 2688841 agttcattta ctaccggtgc aaggaatccg taaatgacta agcgttctgc ttcttctttc 2688901 ggaattccgc ggctcatcag gtagtaaagc tgaatagggt ccacacggcc gacagatgcc 2688961 gcatgtcctg cagttacatc gtcttcgtca attaaaagaa tagggtttgc gtctccgcgt 2689021 gctttttcgc taagcatcag cacgcgtgat tcttgctccg cattcgcttt agaagcgcca 2689081 tgttcgattt tgccgattcc gttaaagata gaagaagcgg aatccttcat cacaccgtgc 2689141 ttcaagatat agccttcaga agctttaccg aaatggatga tttgtgttgt gaagttttct 2689201 gtttgctctc ctcttccgac aacaaccgtt ttcgtatcgc cgtatgtgcc gtcaccgtaa 2689261 aggtttgttg tgttttcgga aatcgtgtcg ccatcgttca tcaggccgag agcccactcg 2689321 attttgctgt cgcgtccgcg cgcagcaccg cggcggttca cataagttgt cacaccgctt 2689381 gacagattat ccaccgcacc gtatgtcacg ctggcattat cacctgtgat gacctcactg 2689441 ataatattga agacagcgtc tttcgggttt acagtgctga tgtagttttc tacatatgtt 2689501 acagagctgt ggtcttcagc cacaatcagc acgtggttga atagagctgt atcattgctt 2689561 tcgtggacat aaacagcctg aaccggcgtc tccacctgaa catttttcgg aacataaagg 2689621 aatgctcctc cgttaacaag agccgcgtga agtgcagtta acttatgttc gtcaaccttc 2689681 acgccgtcct tcataaagta tttctccacc aagtcgctgt gctcgcgtgc agcagtcaga 2689741 atatcagtga agatgacgcc tttgtctttc aattcttgag aaagagaaag atgtgccggc 2689801 gtctggtcac gctgtacgta taatgtttta tcttcgtttt caatgtcgat cagcgctttt 2689861 acttcatcag tcaaatcttc taatgaagaa agcggttcgt tatccactgt atgcttcgcg 2689921 aaattcgtga agttccagtt tgtgattttt gttttgtcag gtttcggcat cggcagatcc 2689981 tcagcttgtt caagagcctg taagcgcagg ttcttcagcc aggcaggttc ttggtgcttt 2690041 tcggaaaagc ttttgagata ctcctgatct acggatagtt ttgtacctag tgtcatatta 2690101 atccccctaa cgcttacgct tcttggccaa cagtttcgtc ttcaatgcca agttcttgtt 2690161 tgatccagtc ataaccttct gcttcaagac gctgtgcaag ctctgcaccg ccggatttta 2690221 caacgcggcc ttgcatcata acgtgaacaa catccggagt gatgtagttt aacaggcgct 2690281 gatagtgagt gatcatcagg cagccgaagt tttcgctgcg cattttgttg atcccttttg 2690341 atacaacttt caaagcgtca atatcaaggc ctgagtcaat ttcatcaagg atggcgattt 2690401 tcggttcaat catcattaat tgaaggattt cgttgcgttt tttctccccg cctgagaagc 2690461 cttcgttaag atagcgctga gccatttcag ggtccatttc aaggaactcc atgttttcgt 2690521 ccattttgcg gatgaatttc atgagagaaa tttcatcgcc ttcttctctg cgcgcgttga 2690581 ttgctgagcg aaggaagtcg gcatttgtca caccgctgat ttcacttggg tactgcattg 2690641 caaggaataa gcctgcctgc gcacgctcgt ccacttccat ctccagtaca tctttgccgt 2690701 caagcgtgat gctgcctttt gttacttcat atttaggatg ccccataata gcagctgata 2690761 aagtggattt accagttccg ttcgggccca ttactgcgtg gaattctcca ccttttattt 2690821 caaggtttac accctttaag atctctttcc cttcgatttc aacgtgaaga tctttgatcg 2690881 ttaatgttga agcagccata tctatacctc caaaaatata taatcattat tctcatttta 2690941 ttctcattct aattttataa caaatgaaaa gtaaatacaa ctttttatcg tgccttgcac 2691001 attcctcaag tttaacaaag atcagcactt tattaaagcg attgaaaaag aaaaagagtg 2691061 gattcccacc cttttttaaa agattgattt tctcaataag ctcccgcaga aatccgcttg 2691121 cttttttcat aatcaagctc tctctgccgc tctactttca ttcttgtttc cagccggcgt 2691181 ccatattcct cgtatccaat tccgtgtgac agctgcatcg ctttttccat ttctgacgta 2691241 taatcgaggt tcagtctgtc ctggctgctg caaataatga atcaatccct tcatatattt 2691301 gctttttatt gtaccagtgc tgcgttggat gccgcaaaaa cgatttggcg tgaaatagcg 2691361 gcagatgaga cgaaagcatc ctttcagaac aaatgagaat ggtttttcgg aatattcctt 2691421 ctcttaatgc gtggtgtttc cgaattcctc aatgcactgt tgaacgactg tcacgccttg 2691481 gctgaaagct gcgccgcctc caaatgccgc tgccacactg acggcttcga gaatgttttc 2691541 ttctgacgct ccctgatcaa gacagccttt tgtatgatag atcatgcaat attcgtcctg 2691601 agcattgatg gcaattccga gggcgatcag ctgtttttct ctttcagtca gagaattccc 2691661 ggcaaagcac tgttcagtaa attcgttaaa ttttcttccc atcagcggca tcttttgttc 2691721 aaatgtgcct aaaccatgtt tatattgttt taacgcgtcc tgcatgcttc ctctgtcttg 2691781 attcaaagaa aatccctcca tctgtttaac attccttttt attatgaaca gcttttagga 2691841 aaatacgcga aaaaaacccc ggaattctca tccggggttt cagtcttatt cagatacagg 2691901 aagcacagct ccgtcgtatt ttttctcgat gaagtctttg atctttttag agtgaagaac 2691961 ttccatcagc gctttgattt ttgcagaatc ttcttcgcct tttcttactg cgatgatgtt 2692021 agcgtatggg ttgtttttcg ttgattctac ttcaattgcg tcttttttag gatttaattt 2692081 attttggatc gcatagttta cattgatgaa gaccgcgtct ccttctttgt tttcatatgc 2692141 ttttgccgtt aattcaggcg ctactttttt gaattcaagg tttttcgggt ttttcttaat 2692201 gtctttcaat gttgcgtcaa ctgtttccac tttagaatca agagtgatta atccagcgtt 2692261 ttcaagcatt gcaagcatac ggccttgttc agcaacgttg tttgtcagaa tgattgtcgc 2692321 accgtctgga aggtctttca gtgatttgta tgttttagag taaataccga atggctctaa 2692381 gtgaacagcg ccggcattca caagtttgta atctgtgttt tctttcattt cttgctcaag 2692441 gtaaggaatg tgctggaagt agttcgcgtc cacttcttta tcagctaaag ctttattgta 2692501 cattttgtaa tcactaagca ctttcacttt cagcgtatag cctttttctt tcagcaatgg 2692561 ttcagcttct tttaaaattt ccgcatgcgg tgtttttgtt gccgcaacga caatttcttt 2692621 cttgccggat tcagcgccgt tattcgaacc gcaggcagcc ataactcctg caaatacaag 2692681 cagtaatgca cccaaaaata gctttttcaa tgtaaatcct cccttatcgt ttgtctataa 2692741 tatttgttat tagatcaccg atgatttgaa taataaacac gatgattaaa ataaacacag 2692801 tagcaacgaa ggtaacatca gcgttattag actgatatcc ttctacgtac gcaaggtttc 2692861 caaggcctcc tgaaccaatg gctccggcaa ttgccgttga accgattaaa gcgatggctg 2692921 taaccgtaat gccagaaata agagcaggca ttgattccgg aatcagcact ttgaaaataa 2692981 tcgtagacgt tttcgcgccc attgatttag ctgcttcaat cacaccttta tccacctcac 2693041 gcagcgcgat ttcaacaagg cgcgcgtaaa atggtgccga gccgattacc agcgccggca 2693101 atgcggcgtt tggccctaag atcgtgccga ctaaaaattt cgtaaaacct aatagtaaaa 2693161 taattaaaat aaggaacgga atcgatctga atatgttaac aacggctgca atcactgagt 2693221 tgaccgcttt attctgccag aggcttcctt tgctcgtcag aaagagcagc aagccgagga 2693281 tgaccccgat gacaaaagca aacagtaaag aaatcagcgt catataaagt gtttcatatg 2693341 tcgcgttcca taattcagtt aaatcaacgt tcgggaagta tttttcaaac attcgtgatc 2693401 acctctgctt tcacctgttt gtcattaatg aatcggatca cgttttgcac ttcttcctcg 2693461 tccccgtcaa tgtggatgaa cagtgaaccg taagccccat ccttcgtctg cgaaattttc 2693521 ccttgcagaa tattgacgct gacattgaag tttctgatca tctctgtaat cagaggctgt 2693581 tcagctgact caccgacaaa tgtgagctga accatttttc ctgatgctgt atcatcaaga 2693641 aggtgctgaa gcgtctcttt cgtttcttcc ggctctgtca cctgttgaac aaatcgtttt 2693701 gtcatttgtt cctttggatt tttgaagaca tcgagaacct cgccttcttc gaccaccttg 2693761 ccgttttcca tgacggcgac tctgttgcag attttgcgta tgacatgcat ttcgtgcgta 2693821 atcagcacaa tcgtcaaacc gagtctttca ttaatatcgg acaatagatc cagaattgaa 2693881 tctgtcgttt gcggatctaa tgctgatgtc gcttcgtcac aaagaagaac cttcggattg 2693941 tttgcaagcg ctctggcaat tccgacacgc tgcttctgac cgccgctcag ctgggacgga 2694001 taagattttt cttttccttc taaacctacc agtttaatca gttcattggc gcgcttgatc 2694061 cgctcgctct ttttcacccc ggcaatttct aaaggaaaca tgatattatc tctgacagtc 2694121 cgcgaccaaa gcaaattgaa atgctggaaa atcatactga tctcatggcg tgcttttctt 2694181 aaaccgcgtc catttacttc attaatcttg gttcccgcca cttccacggt tcctgaggtt 2694241 ggtttctcaa ggccgttcag cagacggatt aaggaactct taccagctcc gctatatcct 2694301 ataattccaa aaatctcacc ttttttaatg gaaagcgaga cgttttggac agcattgaca 2694361 tctccatgtt tcgacttgta aacttttgaa acatcctgaa gattgatcaa agcaatcacc 2694421 tgccttaaca ctattctaag aaatcttccg gttttttctg caaaagaaaa gcctttctgc 2694481 acacttgagc agaaaggctt atataaaatg cctttctctc atctttcaaa gctgaacgct 2694541 tcgtgtgaat tggcaccatt tcaacagtgt tgatggttgc cgggcttcat agggcacttc 2694601 cctccacctc tcttgataag agaaatatat agtctttttc gtccggaaat tcttaatgta 2694661 gaatagcacg gcgaatgatt aaatgtcaat aaaataaatg atgtcaactt ttactattat 2694721 aataatttat tattttttaa ttttttaaaa tcctctgaaa aaatccattt gtcagccaga 2694781 gaatggcttc cagctttaac agggccctga atgacccctt tactttgagg cttccgctct 2694841 gaataaggtg ctgaagggaa atgtctccgt gcaataaatc aataatttcc gtttggtttc 2694901 cgtaaaaggt caggttggac gtttggggcg gagaaacttt tttcatttct ccctgttcgt 2694961 ttattgagac ggttaaggct tctgcttctc cttggaaggt aatgagcaat gttgaggcat 2695021 tcaaaagggg ttttaaaaac agatgctgat actcatcttc taaaacttcc gctttctcca 2695081 tatgtacaac ctcctatttg ttggtcatac atacacattt ctctctttgt cgcaagaacc 2695141 cctttataaa acgaacgaca atttcattgg atatgctgag aaatatgtca taaatgggat 2695201 gcggaagatg atttttgttt gatcagctca tataaataag aaacggaatg aaatgcatat 2695261 cctctttcga ccatctttcc gcctttaaac agcagaaaac aagggacgct ttcaatttga 2695321 tacgcttttg cgaatgtcgg agagtaattg acattgtttt gatagaaggc gacatccggc 2695381 agcatttctt tcaccactgt cagcattttg cttgcaagct ggcaggtgcc gcaaaacgga 2695441 gtatataaat atagaaggta cacatcatct tcaatgtgat caagttcgtg ttcttggagt 2695501 tctttcatgc tatacacctc gggactttct ttcaagaaaa atagtatgga cattcagatt 2695561 cgcacgcagc aatacagaag cgatatggtg cctgggcgca gccgctactt ccttataggc 2695621 tctgtcgaca tggagatggc aggcttcatt aaattcacgc ttcagctgtt ttctcaattt 2695681 ctcacctgat tcatcagcat caactaatat atagacgtct ttatcataaa gctcgtcagc 2695741 caattcctcg agcctcagct ggctgattgt tccgtttgtg cagataatgc gcatcggttc 2695801 attcaggacg ctttcgattt tctctttatc tgatttcccc tcgacaatca taaccttttc 2695861 cagctcatcc atcttcatct tgttcacctg ccgcgtcaaa tttgaaatgt tcagattgta 2695921 aaagaaggca gtgaaattca ccgccaacat taacaccagc cgttttcgta gtcacaatct 2695981 acatattttg cgtcgtctcc agagaccaca tcggctgtct tataaaattt ctcattttca 2696041 aaggaataac cggacttaag ctcatattca ttcatgcttg tcatttggcc gatcatctca 2696101 ttatcatgat ataacgagag ccggccattt tgaaagcggc ctgtcacgtc attggtgaca 2696161 tcgagctttt gtttgtcgaa agccatattg gacacctccc ataacgttag cgtgtccaat 2696221 tgcttttacg gctatcctgt tttagtcttc ttgtgtcatc tcttcgtatt gctctgctgt 2696281 catcagtttt tcaatttcag aagcgtcaga tggctcaacg acgatcatcc atgctttttc 2696341 gtacggagat tcgttgacga attccggact gtcatcaaga tcttcgttta cttccacaac 2696401 cgttccgtta atcggtgcat aaagctcaga taccgtttta acggattcaa cactgccgaa 2696461 tggctcgtcc gctttgattt cagcgcccac ttcaggaagt tcgacaaaca cgatgtcgcc 2696521 tagttcggac tgggcaaaat gcgtaattcc gattctggct ttttctcctt caacttttac 2696581 ccactcgtgt tctcctgagt aacgcaaatc ttttggtatg ctcaattgaa tccctccatt 2696641 ttttacagca ctacaataag aagataccac acttttcaaa aaaaatttac attaagccca 2696701 gttttcttca aattggtctt ctttaaatcc gacagtcact ttttcgccgt ctgttgtaag 2696761 cgggcgttta attagcatac catctgaagc cagcagttcg agctgttcgt cctctgacat 2696821 atgatacagc ttttccttga gattgagctc gcggtatttc atgccgctcg tgttgaaaaa 2696881 tttcttgaga tccagcccgc ttttttcata aagcgctttt aattcttctt tgcttggcgg 2696941 ctgctcagca atatgtattt cgtttatttc tttcccatgc tcttcaagcc acttctttgc 2697001 tttgcggcac gttccgcatt tagggtacca gtaaaaagtt aacgacatct tcttccccct 2697061 caataaaata atcgaggtta ttttaacaca gtttgtttta aaaacctaaa acagtgcttc 2697121 ttaaaaaaga gctccgcgca tgcggagctc atggccaatc agacagtata tttctcagcc 2697181 tcaaaaatgc ctgccgccgc ctcgcgtttt ttctgaatca cgtttttagg cgttacgcgt 2697241 gtcagcttgc gcagagcgga aagcatcatg cggagtgaat ctccttcttc cattgcgata 2697301 agggattcct ttgcatgcgc ttcgatttcg ttaaaggcct cttgaacgaa aatttctgtg 2697361 tacagcacct tttgcgctgc tttttcagcg ccttgtgcgg caatggcctt ttccgttctg 2697421 agcacggctg attccattgc gtatacattg ctgacgatat ccgctacgtt cacgagaatt 2697481 tcttgctcac gatcgatcgc ttttccgtat ttttgcgcgg ctaggccggc agcaaacaac 2697541 gcaatttttt tggcttgctt gacgatatat ttctcctgct ctaagacgcc gcttccaggc 2697601 tcttcaggca taagcatcat gagttcttcc tgcagcgact gcgctttttc gaataaaggc 2697661 agctcgcctt taagcgcttt tttcaggaag gtgcttggca cgattaaccg gttgatttcg 2697721 tttgtgcctt caaaaatccg attgatcctt gaatccctat aggccctttc tacttcgtat 2697781 tcctgcataa agccgtagcc tccatgaatc tgcacgcctt catcaacgat ataatcaagc 2697841 gtttcagagc cgaatacctt attcagagag cattcgatgg cgtattccgc aatcgatttg 2697901 gcgatttgcc ggccgtcctt gagatcttcg gccgtgaact ggctcatatt gtcttcaaac 2697961 agcccgacgg ttctgtatac agagctttcc atcgcataca gccttgaggc cattgtcccg 2698021 attttttcct gtgtcaatga aaaaccagca atcggcgttt taaattggcg gcgctgattt 2698081 gcgtatgccg cagacagctc gatgacgcgt ttagatgcgc cgattgtgcc aaccgccagt 2698141 ttgtaacggc cgatgtttaa aatattaaag gcgatgacat gccctttgcc gatttctccg 2698201 agcaggtttt cctttggcac ttcagcttga tccagaatga gggttcttgt cgatgatccc 2698261 ttgattccca ttttcttttc ttccggtccc gtggagacac ccgggaactc tttttctaca 2698321 ataaaggctg aaaacttgtc gccgtctacc ttagcgtaaa ctacaaatac atcggcaaaa 2698381 gcagagttgg taatccactg tttttcccct gttaatacat aatgggttcc tgcttcattc 2698441 agcacagctg ttgtttttgc tccaagtgca tcagacccag agccaggctc agtcagagca 2698501 taagcggcga tcttttcgcc tgaagcgagt ccaggcaaat attttttctt ttgttcttct 2698561 gacccgaaaa agacgatcgg caaggaaccg ataccgacat gcgcgccata agaaagagaa 2698621 aagcttcccg cacgcgaaaa tttctcagtg atgagtgccg agctgatttt atcaaggccg 2698681 agcccgccgt attcttccgg cacatcggcg ccaagcagcc ctagttcgcc cgctttcttc 2698741 aacagtctga cagaatgctc gaattgatgg ttttcgatat catctatatg agggagaaca 2698801 tcttgctcga tgtaatcctc tgttgttttc gcaatcattt tatgctcgtc agtgaaatcc 2698861 tccggtgtat acatttgatc gtatgtgaca tcctcgatta aaaatccgcc gcctttttgt 2698921 acgtcagccg ctttttttgc catttgtttt tcccccttta gcataattca aatacaccgg 2698981 ccgctcccat tccgccgccg atacacatgg tcacgactcc aaattgctcg tttctccgtt 2699041 tcatttcatg gatgagtgag agtgtaagct ttgtgcccgt acagccaagc gggtgtccaa 2699101 gcgcgattgc gcccccgttg acattcactt tttcttcatc aattcccaat tccctgatta 2699161 cttgaatggc ctgtgaggca aaagcttcat tcagttcaaa caagccgatg tcctgcagct 2699221 gaagtccggc aagcttcaaa gcgcgcggaa tcgcttccac cggtccgatt cccatcactt 2699281 ccggcggcac gccgcctacc gcaaaggagc ggaatttcac aagcggcgcc aggccaagag 2699341 catcggcttt ttcccggtcc atcagcatga cagccgccgc tccgtcactc gtttgtgagg 2699401 aattgcccgc agtcaccgtc ccgtcaacgg aaaaggccgg gcgcaatgtc gataagatgt 2699461 ctgcagtcgt ttgcgggcga acaccttcat cctgagaaaa cacaaactgt ttttccatag 2699521 gcttatggtc ttctccgatt tctgtcaccg tcacttcgac gggtacaatt tcatctttaa 2699581 attttccttc tgcaagggct ttagcggcgt tttgatggct gcgaacggca aacgcgtctt 2699641 gatcctcacg ggagacgccg tattttttcg cgacttgctc ggctgtgtgc cccatgctca 2699701 tataatattc cggtgccttt tctgccaaag caaggttcgg acgggtaaca tgccccatca 2699761 tcggaacttg cgacatggat tctgctccgc cggcgatcgc tgtatcgtag gcgcccagca 2699821 taattttttc tgctgcatac gcaatagact gaaggcctga agagcaatag cggttaactg 2699881 taatcgccgg aaccgtgtac ggcaggcccg cgagcgcacc gatatttctc gccatattaa 2699941 gcccctgctc cgcttcaggt gttgcacagc cgataatcaa gtcatcaata ttgccttcgt 2700001 agccgcctgc ccgtttcagc gtttctttta cacaaatcgc tcccaaatca tccgggcgaa 2700061 cggtggccaa cgatcctttt tttgcttttc caaccggtgt tcttgcacct gacacaatga 2700121 ctgcctcttt cataagctcc ctcctaattc cgtaaaggtt tacctttcac aagcatatgc 2700181 tgcattctcg cttgagattt tgcctctcct gacaaactca aaaacgcttc tctttcgatc 2700241 tccaataaat actcttcatc aacctctgta ccaaacggca cttttccgcc cgcaatgaca 2700301 taagcgagtt ttttcgcgat cttaaaatca tgctcagata tatagccgga cagcttcatc 2700361 tgctcagcgc caagcaagag tgccgcataa ccggtttctc ccggcacctt gaccttttct 2700421 tttacaggcg gccgccagcc ggtatcgtat aaagatgcgg ccagctgctt cgcatcgtat 2700481 aacaggtggt cttgattcac gctgatctga tccgtttctt ttaagatgtt catctcacga 2700541 gcctcttgag cggaagcgga cactttcgcc atcgcgattg tttcaaatgt tttcattgcc 2700601 gcattcatcg gatcatggcc gcggcgaaga tggttgatgt acagctcttt gttacctcct 2700661 ccgccaggga tgaggccgac accggattcc acaagtccca tataggcttc gcttgccgct 2700721 tgaatgcgcg ccgccggcag gcatgcttcc gttcctccgc cgagcgtcat gccaaatggc 2700781 gcggcgacga ccggtttcgc actgtatttg atcttcatca tcgtctcctg aaaacggcgg 2700841 atcacaaaat caacttccaa aaagttgtca tcttggactt ccattaagat catggcgaga 2700901 ttcgcgccga cgcagaaatt tttcccttga ttgccgatga caagcccctt gtaattccgt 2700961 tctgtttcct ctaatccttt gtggatcatt tgaatgatat cgaggccgat cgcattgctt 2701021 ttcgaatgaa attcaagaag ggccacatca tctccaaggt caattaagct tgctccgctg 2701081 tttttcgcaa tcacgccttt tgtttcttta agtgcttgta aatgaattcg ttttttgttt 2701141 tctttcacgg ctctgtattc gccgcggtca taataaaata ccgttccgtt ctctttgatg 2701201 tagaaggttt catttccttt gtccagcatc tcttttatcc agccaggcat atctgctcca 2701261 agctgctcaa gcttttccgc tgactgcttg aggccgatgg cgtcccacat ctcaaaaggt 2701321 cccagttccc agccgaatcc ccacttcatg gcttggtcaa tcgcatgaat atcatcggca 2701381 atctcgccaa gcagctcggc tgagtaaagc agggtttgag aagtgatatt ccacagcaaa 2701441 cggccggccc tgtcatccga ataaataagc gctttcattt tggcttttgt cccttttgcc 2701501 tgttttgccg cttcaagtgc cggtgatttc atttttgtcc gctcgccgta agtaagcgtc 2701561 actgggtcaa gctcataaat cgtttttcct tcttttttat aaaagccttg gccggccttg 2701621 cttccgatcc accctttttc cagcatatcg ttcatgaagc ttggaatgcg aaacacttct 2701681 ttttcatcgc catcagcttt gtcatacaca tttcgggcaa cgtgggcgaa tgtatcgagg 2701741 ccgaccacat caagcgttct aaaggtggcg cttttcggcc tgccgatcag cggtcctgtg 2701801 atcgaatcaa cctccccgac ctgataaccg cctttcagca tttcttggac tgtcacgaga 2701861 agcccgtaag tcccgatgcg gtttgcgata aagttcggtg tgtcctttgc tgtaacaacg 2701921 cctttcccga ggacattttc tccgaaagct gtcataaact ttaaaatatc aggatccgtt 2701981 tccttaatcg gaatgatctc tagcagcttt aaatatcgtg cgggattaaa aaaatgcgtt 2702041 ccaagaaaat gggctttaaa atcatccgac cggccttcag ccatttcctg cactgatatg 2702101 ccggatgtgt tgcttgagac gatgcttcca gtctttcgat gttcatccac aagagcgaaa 2702161 attttctttt tgacttcaag gttttcgaca acgacctcaa taatccaatc tgcttctttc 2702221 agtttttctg catcatcctc cagattgcca ggtgtaatat aggaggtatt tttcgctgat 2702281 gtgaggggag cgggcttttg tttcagcagt tttttcatcg cctgccggct cagcctgctg 2702341 cgcacctccg aactgtcctt cgtcagcccc tttttttcct cttcctttgt caaatcgttc 2702401 ggcacaatat ctagcagcag gacaggaatt ccgatgttag ccaaatgcgc cgctatcccg 2702461 gaacccatta cccccgatcc taaaacggct gccttccgaa tgtgtttgtg catgagatat 2702521 cccccttgaa cattgaatga atagtcattc attttttgac taaaaaaaat gaaacccgtt 2702581 tcttctttca tcttaaaaga tttccggttc gacttcaata gctaatttgt tatttttttg 2702641 tatgaagcct ataaaagtcg ggcaacttaa gcccggaggt gaagggaatg gtacgagaga 2702701 aaaaaaatcc gtcttcagcg gcagtcagcg cggcgagcgt aaagggagat gccggtccga 2702761 ctcagcatta cggcggcgga aaacggacaa gtcaaaatca gcagtataaa aaacataaca 2702821 tgggacaatc ataatgcagc tgcttcccac ggctgctttc actttttcaa aattcctttt 2702881 aacacaaacg ctgcattggc aggccgttcg gcaattcttc tcataaagta gctgaaccag 2702941 tccgttccat atgggacata cacacgcatt ctgtagcctt ccttggcgag ttccttctga 2703001 cgctccggcc tgatgccgta tagcatttga aactcaaatt gcgatgcggg gatttgatgt 2703061 tcggcgacga gctgtttcgt aaatgcaatg atgtcatcgt catgtgtggc gacagccgtg 2703121 tagttcccgc ttaacaactg cagctttatt aagctctgaa aatgaaggtc cgtgcctctt 2703181 ttgtcgggaa acgctacagc cgcagattct ttataagcgc cttttacaag tctgagattc 2703241 ggctttaagt cccgcatctt tctgatatct tctgccgccc ggtacaaata cgcctgaatg 2703301 accgtgccga gcttctcaaa ttcctgtttg cattgcctgt aaatagaaag tgtctgttca 2703361 taatgagaat agtcttccat atcaatggtc acagcaacat catattgctt cgcaacggaa 2703421 agaatggcgc gcaaatgagt aagagcaagt tcttctgaaa gatcgagccc gattgaggtc 2703481 agcttaagtg aaagctctga attcaattga tgttcggcaa tggcttgaat ggctttcttg 2703541 cattcctctg cgacttggtt tgcttctttt tccgaagctg catactcgcc taaataatca 2703601 attgttgcac acaaaccgga tctgtttagc cttttgacgg tcttaaccgc cgattcaatc 2703661 gtatcccctg cgacaaacct tcgtgctcca agccgcgttc cgtatgcttt tgcgaacttg 2703721 gtaagtgttt tattttgaga taagaataaa aacacatgtc tcaacatccg actccctccc 2703781 gccgtcatct tcaaaacacc tgtatataac tcccagtctg aaggaaacta taaaatgaac 2703841 agaaaccaaa ggaggatcac aatggataat cagcagcaat ctcaaatgcc gccttccgtt 2703901 atttcgacaa aggatcattt gtatctcaat gacatgctga actggaattt gctcgcgatg 2703961 aaaaaagcgc atttcatggc gcagcagtgc caggatcaaa cgttaaagca agaactcgac 2704021 cgcgtcggac acatgcatca tgatcactat caaagaatat taaagcacct gcagccaggc 2704081 cagcagcagt ccggctacat ccaataagga ggcgccagaa tgaatcagca aaatcaaaaa 2704141 atcagcaacc cgcagacacc tgtaccgaca acatcggaaa tgaatgacag agatttcgtc 2704201 aacgaattgc tgacaaccga aaaatacatg acaacagctt attgcactgc cttgcacgaa 2704261 ttcagccacg agtctcttta tcaggatatt caatccattt ttgatgagtc acaaaaagcg 2704321 caaagaaaac tatatgatct catgttccaa tatggatggt attctgttga agcggaggat 2704381 tcacaaaagc tgcagcagtc ctatcaaaaa ttccagcaga ccattcagca gcagtctcct 2704441 tatcagcaat aacaacatta gtaaaaagga tacgatgttc tttcgggcat ctatcctttt 2704501 tttgtgtaaa atcagttgac ttttcattta cgcttattta tatttaataa gcattaacta 2704561 ttttgtcatt aaaatatata tacagtgtat gtaacagagg ggaaatgaat atgaagagtg 2704621 cggatcagtt aatgtccgat attcaattat cgcttcaggc gctctttcaa aagatacagc 2704681 ctgaaatgct ggaaagcatg gagaaacaag gtgtcacccc agcgcagctg tttgtgctgg 2704741 ccagcctaaa gaaacacggc agcctcaaag tttctgaaat tgccgagcgt atggaggtga 2704801 agccaagcgc ggtgacgctg atggcagatc gccttgaaca aaaaaatctt atcgccagaa 2704861 cacacaacac aaaagacagg cgagtgattg atctcagtct tactgacgaa ggagacataa 2704921 agttcgagga ggttttggcg ggcagaaaag ccataatggc gcgctatctt tcctttttga 2704981 cggaggagga aatgctgcag gcggcgcata ttacagcaaa actcgcacaa gcagcagaaa 2705041 cggatgaaaa gcaaaacatg aaaagaggaa acggatgaaa atgagtaaag aaggcaaaca 2705101 atcaaaacga acgttattaa taacaggctt aattattgcc atgttttttt cagcccttga 2705161 cggtaccatt gtcggaacgg ccatgccgaa aattgtcggt gatctgggcg gtttgagcat 2705221 gatgacctgg ctgacaactg catatttgtt aacatcaaca accattgttc caattgccgg 2705281 taaactggct gatttattgg gacgccgcat tgtctatgta tcaggtttga ttatttttat 2705341 ggccgcttct gctttgtgcg gaatggccaa caacatgacg gaattgatta tcttccgtgg 2705401 actgcagggc atcggcggag gcatcatgat gccgatggcg atgattgtca tcggtgactt 2705461 gttcacagga aaacagcgtg ctaaattcca aggtgtcttt ggcgcaattt acgggctggc 2705521 ttcagtgatt gggccgcaaa tcggcggctg gattgtagac tcgttaaact ggaaatgggt 2705581 tttctatatt aacctgccag tcggaattat tgcggttatt tttattgcca ggggattaca 2705641 gggacgccag cagactggtc cgatcaactt cgatatcgct ggtattttca caatgattgt 2705701 cggtgtggtc agcctcctgc tcgccttaag ctttggcgga aaagattatg catgggattc 2705761 atggcagatt cttgggttgt tcgctctcgc actgatcggc attgtcagct ttatcatcgt 2705821 agaatcaaaa gcaaaagagc caatcctgcc aatgtattta tttaaaaaca gaacatttac 2705881 atttctaaac ttgatcggct tctttatgag tatcggtatg tttggcgcca ttacgtttgt 2705941 tcctttcttt atgcagggaa ttgtcggtgt aagtgcgtct gaatcgggta caattatgac 2706001 accgatgatg atttctatga ttatcacaag tatcatcggc ggacagcttg tttataaaat 2706061 tgggattaaa ccgcaaatca ttacaggcat gctggttatg gccggcggat tcctgctgtt 2706121 aacgacattg gatctcgaca cgagcaagct tgtcgctaca tcttttatgg cgattattgg 2706181 tctgggaatg ggtcttgtta tgccgattct gacattggct ttacaggaaa gcttttcgaa 2706241 ggaggagctt ggagttgtca cttcatccag ccaattcttc cgttctatcg gcggaacatt 2706301 cggcattacc atgctgggag ccgtaatgaa tgcgagatca ggaaatctat taacagataa 2706361 attggttcca tatttagact ctcttccggc acaggcaagc tcgtttgccg cccagctaaa 2706421 gggtatgatt gatacaaatc cgcaagggct gctgcaatca ctgttcagtc cggacgcggt 2706481 caaacaaatc cctgcggctt tctcatccca tattgtgccg attttaaaaa catcgttgat 2706541 ggattcgctc cacagcgtgt tttatacggg cctgatcttt atcgcagtcg gagccgtatt 2706601 caccttgttc ttaaaaccta tcaagctatc aaataagaaa gcggaagacc aacaagaaaa 2706661 agagaaggcg gcaaaagccg ttgaatcacc ttcccattaa tagagcaccc cgcgggtatc 2706721 aatccgcggg gttttttatt caatcatctg ggctcttcca tttccgaaag accaatcctc 2706781 atcctgattt ccggccagca tgataaacac atcttctttt cttacaccaa gctcggaatg 2706841 aatccggctc gcgattgagc ggtaaagtgc ttttttctgt tcagttgttc ttgactgttt 2706901 cagtgtaaaa tgaatgtata tcagttcatc agtacgctcg acttggagat aaaatggatc 2706961 ataaaaaaat tcgctttttt catattgtct gatgacttgg aaatagtcat cttccggcac 2707021 attgatttct tcaatcatcg attggtggat agtcctgctc agtttttgaa gccacacttc 2707081 gcttcttccc gaccgtaaat gaatctgtac aaatggcatc tccccgcatc cctttcttta 2707141 cagcgtctgt ccgctgtcaa ttgtgataat ttggcctgtg agtgattcct gttcaattag 2707201 tgaacaaatc aatttggcaa catcatctgg ttcagcaata cactgcagca gcaaagagcc 2707261 gatcatgctt ttcatttttt cttcccgtcc ggcccaccat ctcgttgcca cagctcctgg 2707321 tgctacaccg ctcactctga tttcaggcgc taaggcgtgg gccaatgatt tcgttaaacc 2707381 gtgcaccgct gattttgata ctgcgtaagg cattgatgag ccggcaccag ttatccctgc 2707441 gatgctgccg acgtttacga tcgccccgtc cttgcttttc ttcatgaacg gaaccactgc 2707501 ccgcgcgcag aaaaacatcc ctttcacatt gacggcatac agctcatcct agacgtcttc 2707561 tgtcgcagcc tcaagatcat ccattggaat atgccgtgta atgctggcat tgttgactaa 2707621 aatatcaacc gtgccgtgtg tgttcacgat tgcttgaatc atatcctgca cgtcgctgtt 2707681 tttggataca tctgcttgga tggcgaaggc ttgcccgcca gctttttgaa tcatttccac 2707741 tgtttcctcc gcttctgatt gcgagcgtga ataattcacc gccacaatcg ccccacgctt 2707801 tgccaattcc atactggctg cttttccgat tcctgtgccg ccccccgtta cgagagctat 2707861 tttgttcaag acattcattg ccgccactcc ttgctgttga ctaaagtata tttctgattc 2707921 cattgtaatc cagctttgat gttacgtata atgattgtta aagatactag atatcactca 2707981 gattgatagt aaacgaacgg aggagttcaa aatggaaagc ggagatttac gtgtgtttca 2708041 aatggtagct cgtgaaggga ccattacgaa agcagccctg cagcttggct atgtacaatc 2708101 gaatgtcacg gccagaattc aacaattgga agctgagctg ggtaccacac tgtttttgcg 2708161 ccataatcgg ggcatgacac tttctgcaag cggaaaattg ctgctggact acgcaaataa 2708221 aattataggc cttcttgatg aagcgtctaa agcgctctca tcctccgcag aaccaagcgg 2708281 gccgcttatg atcggctgca ctcagacaac cgccgcggta aggcttccaa agcttctggc 2708341 atcttattat gaagaacatc caaacgtcca gctgtcttta acaacaggac atacgcaatt 2708401 tctccttgat aaagttcttc gttatgaatt ggatggcgcg tttatcggat gcgaatgcca 2708461 tcatcctgag ctcgaatcct atcctgcgtt tgaggaagaa ccagtagttg tttcggctgc 2708521 ctccgtgccc gatgttgagg aagccatcac aaagccgatt ctcgtttaca gcacaggctg 2708581 ttcgtatcga gaaacacttg aaaaatggct gcgttccgtc ggtgtcacac agccggtcat 2708641 tatggaattt gggacgcttg aagcaattat cggcggggtt acagcaggtc ttggcatctc 2708701 gttgctgcca agaacggttg tgcagaaaca tgaagcagaa ggatcaattc gattgtaccc 2708761 gctgcctgaa gctctcagcc agatgaaaac agagtttatt gttcgaaaag attcgtttat 2708821 cagcagcgcg ctgagaacct ttatggattc ctttacgcca gttaaaacgg ctgaatcaca 2708881 aaaaagcagt ctgctataat gaacagactg ctttttggct attgtttgtt tcgatgcgct 2708941 tcatttaatt ccttaatatg ctgaatgatc tctttaatgc cctgcttcgc gtcggggtat 2709001 gtcgcattcc aatgcttagc gagcggaggc atgcttttgg ctatatgggt gtacaaaatc 2709061 cattgcttca cttcttcttt tagctcatcg tttgtttcac caagcagaag ctcagtatac 2709121 ttctccagca atccatcaag ctgctcctga agtttttgtt ccattttcca tcttcctttc 2709181 gaaaaaacag caaggagctt tctcaattga aagctccttc gctgcgttat ttatccatgt 2709241 gatgtgaaag ccgcttcctg gacaatgcat ctgcccctgc catgaggaat gcaaagaggc 2709301 gttccgaaga gcgggtcctg tgtaacctga cagttcatag aaaacacatt ttgcacaaga 2709361 tcacaagtga tgacctcttc cggacggcct tctgcataaa tccgtttatc ttttatggcc 2709421 acaagatgat gcgcatagcg gcacgccaag tttaagtcat ggagaaccat aacaatcgtc 2709481 cggtcttcct tttcattcag ctcaaacagc aaatcaagaa tttcaatttg atgcgtcatg 2709541 tctaaatacg tcgtcggctc gtcaagaagg atgatatccg tttcctgggc aagcgtcatc 2709601 gcgatccaag cccgctggcg ctgtccgcct gacaaagaat caacggcacg gtcagccatg 2709661 tcctcaagct ttgttgcttt aagcgctctt tcaactgctt cctcatcctc ttttgaccac 2709721 tgcttcagcc agttttggta aggatatctt ccttgcttca ccagctgatg caccgtcagc 2709781 ccctctggag ccgaaggacc ttggggcagg attgcgagct cttttgcgac ttccttcgtc 2709841 ggaagcttgg caatcgctct tccttccagc agcactgaac cgcctctcgg cttcatcagg 2709901 cgcgctaatg aacgtaaaag tgtcgatttt ccgcagccat tgctgccaat aaatacggta 2709961 atttcacctt tgggaattgt taaattcaac tcatcaataa taacggcatc cccgtatcct 2710021 aagctcagcg tttctgtaga aattgcactc atacccataa ccgctccttt ttgctggctt 2710081 tttagcagca ctatgtattg cacgttttct atatacatgc ttttaagtca attgtcatca 2710141 atgcaaatga ttccgatatt cagccatttg atatggtcat atatccctca ttgtagcaga 2710201 aaacactgac tttgaaaatc attttcaatt agttttatgg acataattga cgtttatggg 2710261 ttttttatca caagattact tcttgatttc tctgatggag ccgtccttca gcttcaattt 2710321 taaatcgata tgatcataat gactgtccag attaaatgct gccagcacac tgtgtatcac 2710381 ttctgtttca gccatttggt ctgtcacgga aagctcgctc aaaatcattt tcatctcatc 2710441 taacgcttct tctccttcct gattgacacc ggagagctta tcctgtattt ccgctttttc 2710501 ctgagtcccg ttctttgtat agattccttc ataacggtta tgctcaccat ccccgtagct 2710561 cacacgaagc gaaaaattac tgtagggaac ggacttcagc tgggtgacgg ctgtattttc 2710621 tccttctgcc tgatgctggt cttcattgaa acggcagccc gcaatcagaa ccactgcgag 2710681 acatacagcc ccggctgctc tgatcaaatg catatgtttc ccccctgtag gattccattt 2710741 attttaggta tatccagaga atgaaatcct cattcagaga agaattgaaa aagccggggc 2710801 atttaacgcc acggcttttt ctttaagatt cggtcatttg taaaaaggtt tcggcgtcac 2710861 gcacagccag cttgatggca ttctcccaga aatcgcgctt tgtgatgtca gcgcccaaat 2710921 gcttcatcgc caaatcctcc actgtcatag aagccgtatc gcgcaatagc gccatatact 2710981 tctcttcgaa tgtgtctttt tcttcaagcg ccaacgcgta aataccaaga gaaaacaggt 2711041 agccgaatgt ataagggaaa ttgtaaaacg gcaccctcgt gatgtgaaaa tgaagctttg 2711101 atgcccaaaa aagcggatga tattcttcta acgcattgca gtatgcctct ctttgcgcct 2711161 cttccatcag ctcattcaag cggctggccg gtaccactcc ccgctttcgt tcctcgtaga 2711221 atctcgtttc aaatagaaat cttgcgtgaa tgttcatgaa gaacgcaacg cttctttgca 2711281 ctttatcctc cagaagaaca agcttttctt ccctcgtctc ggcctgctgg acagtcgcgt 2711341 ccgccactat catctctgca aacgttgaag ctgtttctgc aacgttcatg gcgtaggaac 2711401 ggtttaacgg cctgacgttg agcattgctt cctgatggaa cgcgtgcccg agttcatgcg 2711461 caagggtaga gacatttgag gcgcttcccg aaaatgtcat gaaaatccgg gattccccgc 2711521 tgtccggaaa actggtgcaa aagccgccga ctctttttcc gctcctgtct tccgcctcaa 2711581 tccagccgtc ccgaaacgct ttttcagtga atgaggacag ctttttgcca aacgttgaaa 2711641 actggctggt aatgatattt gcggcttcat catacgaata gacctttccg tcagaaccga 2711701 tcggtgcctc gacatcgtac cagctgagtt tttcaaggcc gagcatggat gctttccggt 2711761 tcaaaaactg aacgaacggc ttcttgtttt cagtgatgac ctgccacatc gtatcaagtg 2711821 tttctttttt catcctgtta atttgcagcg gttccttcag gacattctcc cagccgcgcg 2711881 ctttataggt ttcaagccgg aatcccgcca aatgattcag cgtgctgctg aaaatatctt 2711941 gcttgctctc ccaagcttgg cggaaacgtt catatactgt ttttctgaca gtacggtctt 2712001 gatgatccat catattctcc gcctgaccga cagacaattg cttgttttca ccgttttcct 2712061 catacgggat cgtcattttc ccgacaacca tattgtataa gtcactccaa gcgtgatatc 2712121 cgtccaccgc aaggtttccg atcagttttt ccttaccggg gctaagcttt tcggcaaccc 2712181 tctgtcttct ttcatttaat atgtaagaaa catcgcgcaa tcccggtttt gttaacaatt 2712241 cattccacac gtcttgatta atgtccacaa gtttatgatc taatgtaacg agcgacgatt 2712301 gaaaatctgc ggaaagccga ttcatgaggc ctgatgctct atagcctttt gatcattgat 2712361 attctgggcc tggaggcaag caacaaaagc gccggcctgc tgaagcttga cggatgtctg 2712421 ttcgaataaa tcaagcaacg cggtcagccc ttcagcctct tcaggcgatt caggcacctg 2712481 aaacgcatca gtcctgtctt gaaatgcacg cagactttgt gacagcttct caatataacc 2712541 tttgaattct tccgattggc tcccgccctt aaaaaatgaa tcaagatccc atctttggcc 2712601 taccccttgc agcgccatat cacaaaaccc ctttccttct ttcgttctat tatagaacaa 2712661 ttctgaatta ttgtataaaa atttctatta caggcgtcat ttcgtgttca ggatagtaca 2712721 atagctgtag cagtttaata ggagggttag gatgaataaa aaaatagcca tcgtgacagg 2712781 agcgtccagc ggcttcggtc tgctggcagc tgtaaagctt gcccgatcat ttttcgtgat 2712841 agccacatca agacagcctg aaaaagcgga acagcttcga gaattggctg cagcacacaa 2712901 tgtgtctgat tctattcaca ttacagctct cgatgtcacc gatgaacaat ctatagtctc 2712961 attcggaaaa gctgttagtg cttacgcccc gatcgattta ctcgttaaca acgccggaac 2713021 ggcttatgga ggatttatcg aggatgtgcc gatggaacat ttcagacaac aatttgaaac 2713081 gaatgtcttc ggtgtgatcc atgtgacaaa aaccgtgctg ccttacataa gaaagcatgg 2713141 cggcgcaaag attataaacg tgagcagcat cagcggactg acaggattcc cagcgctgtc 2713201 gccatatgtt tcttccaagc atgcattgga aggtttttct gaaagcctgc gtatcgagct 2713261 gcttccgttc ggtatcgaaa ccgctttgat cgagccgggc tcatacaaga catcgatctg 2713321 gtcaacgtca ttatcaaatt ttatgtcggt gcctgctgac gattcagcct atcatcaata 2713381 ctataaaaag atcctttcct atgttcaaaa aaacggagaa gaaagcggag atccccaaga 2713441 ggttgccgac ctcatttatc aattggcaac aaaacagcac ataaagaatt tgcgataccc 2713501 gatcggaaag ggcatcaagc tcaccctgct gttccgatcg ctttttcctt ggtctgcgtg 2713561 ggagtctatc ctgaagaaaa agctattcag ctgatctaaa ttataattat tataatttag 2713621 tattgatttt tatttagtat atgatataat taagtcaaca gatcacaagg aggacgttat 2713681 cttatgaaaa ctgaaaacgc aaaaacaaat caaacattag ttgagaattc actgaacaca 2713741 caattatcaa actggtttct tttatactct aagctccacc gtttccattg gtatgtgaaa 2713801 gggcctcatt tctttacatt gcacgagaaa tttgaagaac tttatgacca tgcggctgaa 2713861 acagtggata ccatcgctga gcgcctgctg gcgattggcg gacagcctgt tgccacagtg 2713921 aaagaataca ctgagcatgc atctatcaca gacggcggaa acgaaacatc agcatcagaa 2713981 atggtacaag cattggtaaa cgactacaaa caaatcagca gcgaatctaa attcgtgatc 2714041 ggcctggctg aagaaaatca agacaatgcg acagcggact tgtttgtcgg attaattgaa 2714101 gaagttgaaa aacaagtgtg gatgctttcc tcttatttag ggtaacaaaa aagctgaacc 2714161 ttaatcgggt tcagcttttt gttttttctt agcttgaact gctttctgtc tgcttggtca 2714221 gtgttgcgtt caacgttttc gtttttccct ttcgcagcac ttggattgtt gttttatctc 2714281 cgacttttaa gtctttgtaa aggatctgac ggatatccgc actgctttcc acgtctttac 2714341 cgtttagttt gacaatgaca tcctcagatt taatacctgc tttttctgcc ggcgaatttg 2714401 cttgaacttc ttttacataa acacctttgc ccaattgatc tccaaacagg ccgagcgtat 2714461 tttcctgata ggtttcagga acttgtgaca tgtcaatcat ctgcacgcct aaaaacggac 2714521 ggtccacctt cccgttttgc agcagctggt caacaatcgg ctcgacatca ttgcttggga 2714581 tcgcaaatcc aagtgattcc acgccgcttt cgctcacctt caagctgttg atgccgatga 2714641 cctggccgct tgcattgatt aatgggcctc cgctgttccc cggattgatc gctgcatcgg 2714701 tttgcagcac gttcatttcc accgtcccct gtgttgtatc cacatcaatt gtccggttca 2714761 gtccgctaat gataccttgt gtcactgtac cggaaaactg ctgtccgagc gggttaccga 2714821 tagcgattac cttttcgcca gtgcgcagct gtgaagagtc accaaagctc gccacttttt 2714881 ttacattctt gccgctgatt tccaaaactg ccaaatcagt aatggtatcg ctgccgacaa 2714941 gcttggcagt ttccgtttct ccgttgtata gcgtaacagt cagcttgttc gcgccttcaa 2715001 cgacatggtt gtttgtaatg atatacgctt tatcgctgtc ttttttgaaa ataacacctg 2715061 acccggttcc gctttcactt tctgagctgg agcctcctcc cgtgccgaat gtgttatttt 2715121 gagaggtttg gatatttgag attccgacaa tcgtaggctc taaatcctct accatatcag 2715181 cgatgtttga tgcgttcgtt atcggcgccg ttgtaaaatt atcagactgc acctgtttat 2715241 ttgcggaagc ggtttcggtc gcctgatttt ggtctgacgg cagataaggc gcgatgccaa 2715301 gcatgaggcc cccgccgata ataccgccta aaatcgggct cagccatgcg gctctccgtt 2715361 tcttttcttt tttcacagcc gtttcttgct tttccatttc taaagcagaa gccgtttcct 2715421 gccgtcccgc ttcatacgac acaggcgcgt caagcaattc ttgttcagaa tgtccaatca 2715481 gcttctggtt ttctgtattc tgctgttctg tatgtgaagg ttcagtttga tgttgatcgt 2715541 tttggccatc acgtcgataa tccatgttct tacactcctt taacggttat tcatttatcg 2715601 ttacatattc atcgcatgta caagttcaat tgtcccaata atgaggagaa aagcaaagca 2715661 ccaaaataga atatgtttga tcatcctaca tcttcctcgc tctttttctc ttcctttctt 2715721 cccttaacca tatcataaac aaacattgtg ggataaaaat gaaaagaata tgtgaaatta 2715781 tgaaaattgc ctgccgtatg ttaaaactag tttataatga cgttgaaagg atgtgaagag 2715841 ccttgtcata caccatttat ctagttgaag atgaggataa cctgaatgaa ctgctgacga 2715901 agtatttaga gaatgagggc tggaacatta catcttttac gaaaggtgaa gacgccagaa 2715961 agaaaatgac accgtctccc cacctatgga ttctcgatat catgctgccg gataccgacg 2716021 gctatacatt aataaaagaa atcaaggcga aagatcctga cgtgccggtc atttttattt 2716081 ccgcccgaga tgcggatatt gacagagtgc ttggcttaga gcttggcagc aatgactaca 2716141 tttcaaagcc gtttttgccg cgggagctga ttatccgtgt gcaaaagctg ctgcagctcg 2716201 tatataagga agctcctcct gtccaaaaaa atgaaattgc cgtctcctcg tatcgggtcg 2716261 ctgaagacgc ccgcgaggtc tatgacgaaa acgggaatat catcaatttg acgtcaaagg 2716321 aatttgatct gctgctatta tttatccatc ataaagggca tccatactct cgtgaggata 2716381 tcctcctaaa agtgtgggga catgactact tcggaacaga ccgggtcgtt gatgatctcg 2716441 tccggagact gcgcagaaag atgcctgaat tgaaggtgga gacgatttac ggtttcggct 2716501 acaggatgat gtcatcatga aaaacaagcc gctcgcgttt cagatatggg ttgtcatatc 2716561 cggcatcctg ttagcgatat cgattttact gcttgtgtta ttttcaaaca cgctgcgaga 2716621 ttttttcact aatgaaacgt atacgacgat tgaaaatgag cagcatgttc tgacagagta 2716681 ccgcctgcca ggttcgattg aaaggcgcta ttacagcgag gaagcgacgg cgccgacaac 2716741 tgtccgctcc gtacagcacg tgctccttcc tgaaaatgaa gaggcttctt cagacaagga 2716801 tttaagcatt ctgtcatctt catttatcca caaggtgtac aagctggctg ataagcagga 2716861 agctaaaaag aaacgttaca gcgccgacgt caatggagag aaagtgtttt ttgtcattaa 2716921 aaagggactt tccgtcaatg gacaatcagc gatgatgctc tcttacgcgc ttgattctta 2716981 tcgggacgat ttggcctata ccttgttcaa acagcttctg tttattatag ctgtcgtcat 2717041 tttattaagc tggattccgg ctatttggct tgcaaagtat ttatcaaggc ctcttgtatc 2717101 atttgaaaaa cacgtcaaac ggatttctga acaggattgg gatgacccag taaaagtgga 2717161 ccggaaagat gaaatcggca aattgggcca taccatcgaa gagatgcgcc aaaagcttgt 2717221 gcaaaaggat gaaacagaaa gaactctatt gcaaaatatc tctcatgatt taaaaacgcc 2717281 ggtcatggtc atcagaggct atacacaatc aattaaagac gggatttttc ctaaaggaga 2717341 ccttgaaaac actgtagatg ttattgaatg cgaagctctt aagctggaga aaaaaataaa 2717401 ggatttatta tatttaacga agctggatta tttagcgaag caaaaagtgc agcacgacat 2717461 gttcagtatt gtggaagtga cagaagaagt catcgaacga ttgaagtggg cgcggaaaga 2717521 actatcgtgg gaaattgatg tagaagagga tattttgatg ccgggcgatc cggagcaatg 2717581 gaacaaactc ctcgaaaaca ttttggaaaa tcaaatccgc tatgctgaga caaaaataga 2717641 aatcagcatg aaacaagatg atcgaaatat cgtgatcacc attaaaaatg acggtccgca 2717701 tattgaagat gagatgctct ccagcctcta tgagcctttt aataaaggga agaaaggcga 2717761 attcggcatt ggtctaagca tcgtaaaacg aattttaact cttcataagg catctatctc 2717821 aattgaaaat gacaaaacgg gtgtaacata ccgcatagca gtgccaaaat agactgtaga 2717881 tgttttgcag tctatttttt tatgtgaaag aatagccgtt aaaatctctg taatttgttt 2717941 tgagcggctg tttgcattga tgaacccatt ttttctctga caaggtctgc ttcggatatt 2718001 tgactttctc cactttgatt cctctgtttc gcaagcggct gatcatttcg tccaattctc 2718061 tcattctaga ttcacccttt cgcttgagct ttgaccattc ggtcatctca atttataata 2718121 taaataatac atgataaaaa aacaagttac aataaggtta attttataac agacggtgtg 2718181 actatatggt catatcctag caggcctccg ggctccgaaa gggtggaacc attgaaggaa 2718241 aaagaaaaac tgattattga aacagcctta aaactatttg cccaaaaagg atacaactca 2718301 acatcagtcc aggaaatcgc aaaagaatgc aaaatatcta aaggcgcttt ttatatttat 2718361 tttccttcga aagaagcgct tcttctctct atgctgaact actattatga taaaacgttt 2718421 acccgaattt taaatattaa aacgaagggc gacagcccca gaacggctta ccgtaaacag 2718481 ctgaccgtcc tctatgaaaa cattcttgaa cacaaagatt ttatcagcat gcagttgaag 2718541 gagggttctc tgccttacac agaagaagtg gagcaatgcg caaaaaaaat ccgccagtcc 2718601 tcacttcaat ttcatatcga cagcctgctg aacatctatg gaaaaaaagc ggaaccgtac 2718661 actgctgagc tttgtttttt aatagagggc atcagccaga tttacctgga atgcatgatt 2718721 ttgctcgggt acactgtgaa gccgtctcaa ttagctgata tcattatgaa tcgaattgat 2718781 gatatggtaa aaggcatgtc tgaacgaaac gataagcctt tcatcacatt ggaagaggcg 2718841 agctctttat tcggacctct tacgcacgga cggcctgacc cgctgactga atcaattgtg 2718901 aaaagcctac gtgacaaaat taacagctta aacacaaact cctctcttga attatcggag 2718961 agcttggaca tacttgaagc agaaatgaag aaaaaaacac cgaagctggc gatcataaaa 2719021 ggaatgattc ataatctgac ggagtctgaa gctctcgcca aagatgcgga acagcttaaa 2719081 tatttattaa aacagcaaca tatttagaag aacggctgct taaaaagcag ccgttcttcc 2719141 tattacgcct ttggttttac catgtcttcc ggcttaacca tttcgttaaa ttgctcctct 2719201 gtcagcaatt caagcttcaa agctgcttct ttgagcgtca atccctcttt atgggcaagc 2719261 ttggcgattt tcgccgcgtt ttcataaccg atatgcgggt tcagcgccgt aacaagcatt 2719321 aatgaatttg acaggttttc ctgaatggtt tctttattag gctcaatacc gacagcacat 2719381 ttatcatgga atgaattcat gccgtcactg agcagctgca cagattgcag gaagttgtaa 2719441 ataataacag gcttaaacac gttcagttca aagttcccct gactcgccgc aaagccgatt 2719501 gtcgcatcgt tccccatgat ttgcgctgcg atcattgtta acgcttcgct ttgtgtcgga 2719561 ttgactttac caggcataat agagcttccc ggctcatttt caggaatgac gatctccccg 2719621 atgccgcagc ggggtccgct tgcgagccat ctgacatcgt tcgcgatttt cattaagtca 2719681 gccgcaagcg cttttaatgc gccatgcgca taagtgattt cgtcatggct tgtcagcgcg 2719741 tggaatttat tcggcgagct gctgaacgtt tggccggtca gcttagtgat ctcttctgag 2719801 acaagctctc caaactctgg gtgggcgttg atacccgttc cgacagccgt tccaccaatt 2719861 gcaagcgcac gcattttatc tgtcgcttcc aaaatcattt ccttcgaacg gtccagcatg 2719921 tgaacccatc cgctgatttc ctgtccgagg gtcagtggcg tagcatcctg aagatgcgtg 2719981 cgtccgattt tgacaatatc attgtatgct tttgcttttt catccagtgt attgcgaagc 2720041 tgatcaagcg ccggcacaag ctgctcgtaa acagccaaaa cagcggcaac atgcatcgca 2720101 gtcgggaatg tgtcgtttga gctttggctt cggttcacgt catcatttgg atgaatcgtt 2720161 tgatcagagt tcttctcttt taataaagca gtcgcacggt tggctaccac ttcgttcatg 2720221 ttcatattgc tttgtgtgcc gcttccggtc tgccatacga caagcgggaa gttgtcatcg 2720281 tacttgcctt tgagcacatc atcacaaacc gctgcaatcg cttctgcttt ttcagcgtcc 2720341 agattgccga ggcgtttatt agctagagca gtgcttcgtt ttaaaattgc aaacgccttc 2720401 acaacacgca tcggcatttt ttcagaaccg atcttaaagt tctccttgct tcgctgtgtt 2720461 tgggcgcccc aaaatttatc agcaggaact tttacttctc ccatggtgtc tcgttcaatt 2720521 ctgtattcca tttatgtatc cctccataac ggttgcttca atagatcata attcgccaat 2720581 gacacaaaaa atccttttta tttttcgatc ttggcagatt ttaattttaa ttcaagatat 2720641 acgcgggaat cctttgaata tttgtatttt ggatttgtcc tgccgtactc ctttgatgta 2720701 taagagacat cataatgctg ttcaaatgat ctaatgagct gttcaatttc ttcttgtttt 2720761 ccagctagcc ttacctgtgc cacttcgtat cctccgcttt cataaaaaaa cttactccat 2720821 gaaatactct aacacagtat atcatttttt taacaggaaa agataacctc tactaaggtt 2720881 ttggataaga ggtgacctca ttggaacaaa cagagtttaa ggaatatata cacgataatt 2720941 tagcattggt gctgccaaaa ttaaaagaaa acgatgatct ggtgaaaaac aaaaaaatgc 2721001 ttgcgaacgg actggttttt tactatctct atttcagtga aatgactgat gagaataagg 2721061 tgtcagaagc cattaaaact ttgattaaag atgaggagac cttaacgctt gaccaggtca 2721121 aaaaacgcct tgaccagctt gacgcaagac ctgttgaaac tgcaaaaaaa acgattgaat 2721181 cgattctcaa cggcaattgt gctgtgttta tcaacggatt ggataaagcc tatattctga 2721241 ccacaggaaa gaaaaaaaca agaagcctga cagagccgac aactgaaaaa gtggttcgcg 2721301 gcccaaaagt agcgtttgta gaggatattg atacaaatct cgctctgatc agacaaagaa 2721361 cctctcatcc gaaattgatc accaaaaaaa tcatgatcgg cgaaaacaag ctgaagcctg 2721421 cagccattat gtacattgaa ggcaaagcaa aaaagtccgt cataaaagaa gtgaaggcgc 2721481 ggcttaaaaa tatccagctg gaagatatcc aggacagcgg aacgctcgag gagctcattg 2721541 aagataataa atattcacca tttccgcaga tacaaaatac ggaaagacct gacaaagtat 2721601 cttcagccct gtttaacggc cgtgtggcaa ttttggtcga cagttcacca tttgtgctgc 2721661 tggtgccggt ttctctcggc atcctgatgc aatccccgga tgactactat gaacgctgga 2721721 tttcagcatc tcttatccgg tcgctgcgct ttgcttctat ctttatcacc ttgtttttgt 2721781 catcgattta tataacactt gtttccttcc atcaggggct gctgccgacc gcactcgccg 2721841 tcacgatttc ggcgaacagg gaaaacgtgc cgttccctcc gatatttgaa gccctgctga 2721901 tggaagtcac catcgagctg ctaagggaag ccggactgcg actccccaat ccgctcggac 2721961 agacgatcgg cctcgttggg ggcgtagtca tcggacaggc tgctgtagaa gcgaatctcg 2722021 tcagttcgat tttggtcatt gtcgtcagtg tcattgccct ggcatccttt accgttcctc 2722081 aatacggaat gggtctgtct ttccgggtgc tgcgttttat ttcgatgttt tccgccgcta 2722141 ttttagggct atacggcatt attttattta tgcttgtcgt ttatacgcac ttaacgagac 2722201 aaacgagctt tgggtctccg tatttttcgc caaacggatt ctttagcctg aaaaatacgg 2722261 atgactccat tatccgtctc ccaattaaaa acaaaccaaa agaggtgaat aatccaaatg 2722321 agccaaaaac agactccact gaaacttaat acctttcaag gtatttctat tgttgcaaat 2722381 acaatgcttg gggccggact tttaacattg ccgcgagcgc tgaccactaa ggctaatacg 2722441 cctgacggct ggatcacgct gatattagaa ggtttcattt ttattttctt catttattta 2722501 aacacgctca ttcagaaaaa acatcaatac ccttcactct ttgaatattt gaaggaaggg 2722561 cttgggaaat ggatcggcag catcatcggc cttttgatct gcggctattt cctcggcgta 2722621 gccagcttcg agacacgggc aatggctgaa atggtgaagt ttttcctgct ggagagaacc 2722681 ccaattcaag tcattatttt aacgtttatt tgctgcggca tttatttaat ggttgggggc 2722741 ttaagcgatg tgtcgcggct gtttcccttt tatttaacgg taaccattat tattttgctg 2722801 attgtgttcg ggatcagttt taaaattttt gatatcaata atttgcgtcc tgttttaggc 2722861 gaaggccttg gacccattgc aaactccctt accgtcgttt ccatctcttt tttaggaatg 2722921 gaagtgatgc tgtttcttcc tgaacatatg aagaaaaaga aatacacgtt cagatatgcg 2722981 tctctaggat ttctgattcc gattatctta tatatcctta cgtatattat cgttgtcgga 2723041 gctttgaccg ctcccgaggt gaaaacgctg atttggccga ctatttctct ctttcagtcc 2723101 tttgagctta aaggcatatt tattgaacgg tttgaatcct ttttactggt ggtctggatt 2723161 atccagtttt tcaccacatt tgtcatttac ggatactttg ccgctaacgg gctaaagaag 2723221 acatttggat tatcgactaa aacaagcatg gtgattatcg gcataacggt cttttatttt 2723281 tctctctggc cggatgacgc caatcaagtc atgatgtata gcgattatct tggctatatt 2723341 tttgtctccc tgtttctgct tccgttcatt ctctttttca ttgtagctct caagaggagg 2723401 attacaacaa aatgaaaatc cggattttat gtatgtttat atgcacccta ttgctgtccg 2723461 gatgctggga cagtgagaat atcgaggaat taagcttagt gatcggaata gggctagaca 2723521 agcctgacga tgaaaattta gagctgacac agcaaattct cgtgccgaaa ataatcagcg 2723581 ccaaggaggg ctcttcatct gatccgacac agctttctat cacaaagggt aaaactgtcc 2723641 atcaaatgat gagaacctct gcattaaagc ataagcctac gttttcacag catttgcgtc 2723701 tcattctgct ttccaaaagc gtgattgcgg atcaaattgg aatggacgcc attattaacc 2723761 agtttgtcag agacaacgga acaaggagga gttcctacgt ctttatcacc aacggccgaa 2723821 ctaaggatat atttaacatg aatgatgaag gcgaacccgc atccaacgtg atatatgatc 2723881 tgacagagaa taataaggtg acgatcagaa cgatggagcc agttacattg ggggagatct 2723941 cagaacactt aacctctgac gattcattcc tcatccctca tgtcggtaag gaaaacggca 2724001 agctcgcgat aaacggagcc tctatcataa aaaataaatt atggcaccgg gacctcaccc 2724061 cgattgaggt tcaaaatatc agcttatttt caggcactgt cgagggaggc gtcattgact 2724121 tgaagcgcga tggccatctc ttttcttatg aagtatattc aagcaatcgg aagatcaaga 2724181 cggcatacaa ggacggaaag ttcaaattca ccgttacccg caatattgaa ggtcgtctat 2724241 ctgaggactg gaatcccaat gaagactcgt ttaaggattc atatattaaa agtattgaaa 2724301 agacagtcga aaaacgagta cacgaaacag taacgtcatt tattacagag aagctgcaga 2724361 aagagatcaa agcggacgta accgggctgg gaaacgaggt cagaattcat tatcctcaaa 2724421 agtggaaaaa gatttcaaga aaatgggatg atgattattt cagcaatgcg gaaatagact 2724481 accgggtcaa tgtgattgtc agagacttcg gaacgaaagg cgcaaacaaa tagcagccgc 2724541 ctaattcacg agatgatttc ggtgtgcgta caccgccgcc tgcgtccggt cactgacatc 2724601 cagctttgat aaaatattcg taatatgtgt tttgactgtt ttaatcgtaa taaacagttc 2724661 ctcgcctatt tctttgtttg tctttccttc tgcgatcagg cagagtattt cgagctcccg 2724721 ttttgtaagc gattcatgcg ggagcgcgtt ttcacctgag tggcgcagcc tggataatac 2724781 ttttcccgcc acttttgact ccagcttcgg ctctcccttg cttgcggcgc ggatggcatc 2724841 ggcgatttct gccgcttttg aggttttcaa cagatagctg agcgcgccag cttcaataac 2724901 cgggtacact ttgtcatcat caatgaagct agtgagcaca ataattttcg ggtcggaaag 2724961 ctcccggcaa atttgctttg tagcttcaat gccatccatg ccctccatga caaggtccat 2725021 taaaatgaca tcaggcgaca gttccacagc aagccgaaca ccttcgctgc cgtccgatgc 2725081 ttcgccgatg acttcaatat cgggctgcgc ctccaaaaaa gccgcgagcc ccattctgac 2725141 catttcatga tcatcaatca ataatactcg aatcacgttc gttctctcct ttttcttccg 2725201 gaaaaatcgg gaccttcact tcgatttgag tgccttttcc ttctactgaa atcacttcgg 2725261 cgacaccgcc gatttcactt gcacgttctt tcatagaatt caagccgtat gaggaggctt 2725321 tcacctggtc cattttaaag ccttttccat tatcaatcac cttcagacgg agctggctgt 2725381 tctttatgcc cagaatcacg gttacttttg acgcttttga atgtctaaat acgtttgaaa 2725441 gggcctcctg cacgattctg aacaagtggt cttcaacacc cttggatatc gctgtgtcct 2725501 gtatatccca ctcaatatca atcggctgct tttttcggaa ctcgtccaaa agctccgtaa 2725561 ggccctcctt cagccctttt ccttcaaggg taacaggccg taaatggagc agcagcgccc 2725621 tcatctcatt ttgggcttcg cctgccatat gctcgaccat cctgatccgc ttgactgttt 2725681 tgtcatcagc atccttgaca tgttccagca cggctgatgt catcatcgat atggcaaaga 2725741 gctgctggct gaccgcatca tgaagatctc tggccaatcg ctggcgttct tctgagataa 2725801 ccgacttctt catttgagcc tgccattccg cacgttcatt ggaaagtttc tggagggatg 2725861 cgacttgaag ctccacgcgc ttcgccattt cgttcagctg atcagcagcc aggccgattt 2725921 catcatcacc gagcggcggt atccgataag cgaaattgcc gttttcaaag gttaaaatgg 2725981 attcaattaa tgtatcaatc cttgtcttca accggttgcc gtacatatac cctgaggcga 2726041 aaccgacggt cacgctgatc agaagcaaaa tcaggataaa cggaattccg aaccagcttg 2726101 atgacagcaa aacaagcgga tcgagccgat agtaaaacat cataaaggaa atcaggcaaa 2726161 caaaaaggag caggctgatt cccgttgtca tgcggatggc gcgccattgg aggctggcaa 2726221 gcattttttt tctcatacgt acttcacatc cacatcaccg ataaataagg aaacggacac 2726281 ttttacccgg cgctttgact cgctaaaatc agttgacgcg gcatatacct tcgtgcttaa 2726341 tccgcttttc ttcgagccga tcagattaat gtctcctata aaaacagccg agctgacagc 2726401 cacttcaagg tccgatggta cataaatatc aacgttacca atgactccgc taatgacgat 2726461 tgtactttct ccctcgggaa tcatcgcttt agataaatcg attttgatat caccgataaa 2726521 accagagaca tttaaatcgt tcaggtcaaa cggctgcttc atcatttgca gctcaccgat 2726581 aaaaaagctg cgcatgtcgg gatgttttac atcttttggc ggctcatgat gttctttttt 2726641 attgagattg acctgtttct cattcggttc aaatatcggc ttccctttga taagcctgta 2726701 gccggcgtaa atcagaaatg cggcaaacgc atagccgaat aaattaaagg tgatgctgaa 2726761 gaggtttttc aaaaatagaa acgcggcaaa gatatacatg acggagccaa gccaatcacg 2726821 ggaatatttt ttaaggaaat agccggcaat cagaaaaaag agcggccaaa acagcagatc 2726881 gcctattccg ataatttgca aaaacatact gatgccgaat aaagcaatga tcaatccgag 2726941 aagctgtttt tttgtcattc ctggtgtccg cctcctttct tctgcctagt gctaccgtat 2727001 cgctagatcc ccgctgtccg ttttgatgtc gattggatgc cggccgcttc cttgcgtgcc 2727061 tgtgatgtga tgctgttctt tatgtccttt atcagcaaat gaatacggcg aactgacgtc 2727121 accgcttgct gataaagcat tgactgcaaa gctgccattt tggggaaggc ttacattagc 2727181 atcaccgctt gtcagcgtga cagatacggg accggttacc tttttcaata cagcattaaa 2727241 atctcctgaa gtcattttca catcaagaga gcctgataca tgaaccagat ttgcgtcccc 2727301 tgaagctaaa tcaatgccgg ctgttttgga gacggtattt gaaatggaaa catcccccga 2727361 tgatgccttc actttcagat cttgaatgcg gacgtccgtc acgctcgtat ttccgctcgc 2727421 agatactgcg ttcagcccgg aaagcgcaag atggtcattc ccggccacag acacgtcacc 2727481 gcttgaggtt cgtactgcca gatcaccttt ataatcatac ggaagcctga cgataagagt 2727541 tgaacggtta aatccattca aaaattgaaa ttctttttcc tttacggtca gctccagttt 2727601 tcttttgttt tcagtaacaa ataactttcc tgagtctcct gaaatgcctg ccgatatgtc 2727661 acttcgttct tccgctataa tccggacatc cttgctatcc gactcaatga ccatgctgtc 2727721 aatgtcccgc ggcgatgcgc tggctgaatc agcttctgtg ccatttatga aacctaggcc 2727781 tgcagcaaac acatctttta cgacgacggc gaaaaaaacc agaataccgg cagtgatcaa 2727841 cagtttgcca agcatttttt tcattcggtt tcatccttct cattcattct attataaagg 2727901 aaaagcttgc gaattgatac gtgcggaagg gaaggacttg accgcaaatc cttccccgtt 2727961 ccgcttattc atttgccgct tttgtctggt ctgatttttg cagtgaaagt gtccgcattt 2728021 tttcaatctc cgcttccaca tcgtctgcga attctttacg tgtaagttct gtgccggctt 2728081 ccgctgactt tgaataattc gcgcggattt ccatttcttc aatacgattt tcaatacgta 2728141 aaaattcacg atacgcgctt tcactgtcaa ttttgtcaaa tgtcgtattc atatgctctt 2728201 tagctttcgc cgcatttgcc cgcgcaatca gcgcctgttt tttatccttt acgtcctgaa 2728261 gctttgtttc aagtgcagcc agctgctctt tcagatcagc cagctgactg tttgcctgtt 2728321 cataggaagc tttatgctca gccgccttcc cttctaaata cttcatttca gtcagcgcct 2728381 ttttcgccag ttcttcttca cctgcgtcaa atgcgagctg tgcctgattt ttccgtttgc 2728441 cagccacttc agcggcttct tcatattttt tcttaaattg ataggcaatc gtgtgctgtt 2728501 tcacaattgt ttgctttgct tttgcgatgt cgctttccat atcgcgtaca tattgattca 2728561 gcatcacctt tggattctcc attttatcaa gtccttcatg aactgacgca acaaacatgt 2728621 ctctgattct ttttaatacc atacctgatt cctcctaata tattgatatt attttttctt 2728681 caaaaattct tcccattcgt catcaaagtg agattggtag gcagcagaag ccggttcagg 2728741 atcaaaagat gatacaccgt tatcagctga tccgtttttc atcagcttcc agccgtaata 2728801 caccatagcg gccgccaatg cgattccgac gacaaacgga agtgagcaga tgagcataat 2728861 ggctccgata ccgcccacga tgattcccgt gatggttttt cccgcggcaa accttttgat 2728921 tcctgcgtat gtcatcaagc tcccgatggc gagcgggatg ataaagccga agcttcctcc 2728981 tccaaaaaag acggagatcc caaatacaat taataagaat ccgcctattg ttttcttgtt 2729041 tattttcatg cagatcctcc tttcgttttc cttgtcttca tcttatacaa gttggaagat 2729101 atgcaaaacg aatcagagat tgatttttat ataagaccgg agtcgtatct cgcaccggac 2729161 ccattggcac aaaaaaacgc catgcacgag gcatggcgtt ttaaaaccct ttacagatga 2729221 acacttgctt ccctttcttt aattaggtcg gacctttctg ctttggccaa ttttgtaaac 2729281 agcaagattc cgatacccgc aataatttcg acaatcccac cgacagcgat cactttacct 2729341 gagccgaaag cattagcggc atacccgcaa atgacagctc cggcagggat cgaaatattt 2729401 gagatcatat gtataacggc gtaaacctgc ggctgatcct cactatccac agacgtctgg 2729461 ataatcgtgt actcaggaac attaacagca ctgactgcgg caccaaaggt aaaagcagcg 2729521 aaaaagacga gcggcaaaaa ggtattcatc ccggtaataa agaaagcaaa tccttcaata 2729581 atgccggcag tgacgaataa caagccgtac ctgtttacct tgactttcgc cagcacaaac 2729641 cctaataaaa acgcgcccgc ggcggtggtg gcctttaaaa gcgagtatac gatcggctgg 2729701 ccgtttaaat cttccgcaac gtatacggca gagagcgctt cccatggggc agccgcgaaa 2729761 ttcataaaga tacagtaaat ggcgagcgga tataaaatct ggtgttttct gacgagccta 2729821 aagccgcgtt tcagtcttcc gatatatgtg cctctctgtg taacaaccgc agactctgat 2729881 tgagattcaa ccgcagtgta cttaataaaa agaacgagaa aacctgacac caaatagagc 2729941 acaagtgcga taagcatggt ataagaagga ctaataaatg taagaaaagc gccgcataat 2730001 gtgacagccc caagccggac aatttgagcg gaggattgca gcacagcgtt tgctttttga 2730061 atgccctgtt cattgacgat ttgaggaatc aaagcgatag aggcgggatt gtaggcagct 2730121 ccagtagctg aatgcacaat cataagcgtc atgacaaacc acagcggaga gaagcccgca 2730181 aaatgacata gagggataat caaaacaatc gccgcccttg tcagatctga aaagtacatc 2730241 caaaatttca gcgtggtctg tttcataaaa ggccccgtca caggcgccag aacggcttcc 2730301 ggcaaaaacg tgacagcaat caataaagca gtgccgatcg cacctttgcc gtcataaatt 2730361 aaaaaccata atattgaatt aaatgcgaac atatcgccgg atatcttgac tattcttgag 2730421 aaaaacagat aattgaaatt tctcttccag atgctatcac tttcaattaa attcaccatc 2730481 catcagagcc ccccgttgcc tattttttac atctatttat tacaatatct catttttcca 2730541 tttttcagtc aataattcat aaggttcatt ttttgtcgta aaatgggaaa ttgacagagt 2730601 gaaaaacaaa aaaagccggc atgtatttga acacgccggc tttccttttc actttttatg 2730661 attcgctgct gtttcggtcc cgaaacacaa tggcacttct ttcatattct acatcgccaa 2730721 taccgcttct tgcattcaca acccgggcgg cggcaaagaa ataatcggac agacgattga 2730781 gataacgcag cactgtttca tgaatctcct ccgatttcat cagcgccacc actcttcgtt 2730841 ctgcccgcct tgtaatggtg cgtgcgatat ggagaagcga agcacacttt gatccgcctg 2730901 gaagaataaa tttcttcagt tccggcgctt ctgctgtata ggcatcaatg cgcgtttcta 2730961 aaaaggaaac agattcttcc gttagtttat agtcttttct ttctgtgacg attgccagat 2731021 cgcctccgca gtcaaacagc tcatgctgga tggtcagcag ctcggctgtc agatcttcaa 2731081 agccgggctg cccggaaagc tctgccaaag caagcccgat aaagctgtta agctcgtcaa 2731141 tcgtgccgta gctttcgacg cgtaggctgt ccttgtccgt tctgcccccg actaagcccg 2731201 tttgtccctt atcgcctgtt tttgtatata gtttcatacc ctgaatctcc tttacagact 2731261 tattcaaaca actcagcagc ctcttttata cattcagctg tccctttctt tatcaattgg 2731321 ttcagccgct gttctatgtt ttctgattgc tgagtttgag tcgcggcgat gagaatatca 2731381 cctgtgcctc ctccgtctcc cagcactttc gtccgttctg cttcggcagc cataagagct 2731441 ttgatgaaga attgatctgc cgcatagccg ttaatcaaaa tccaaatcga aaagccggtc 2731501 tgaacgcata tgaaaacgga taactctccg tcttcatatg ttcgatacac gaaacggtca 2731561 agtctttctg aagaagccat cgcacacgtc tcctgcagtt gaaaaccgct ttctgaaaga 2731621 caggccgtaa gtccttctat cggatctggc tgatctggca gccgtttatg gatcagcgtc 2731681 ctgctccacg aaaaccctgc accgataggc gtggaggaca atgttcgaag cgggatttcc 2731741 gtttgcagaa gaatgtcatc acgccccgct tggagcaatg cttcaaatgg gatagactgc 2731801 cgcttcacgc tatctttttc aggctgaatc acaatcatcg gtttaggtga gctttgatga 2731861 accaaggcgg tgacatctgt atcgtacacc gcctttatgc tttgttctgt aacagcatat 2731921 tccggttttt gcttaggccc ggcggtaccg tttttcataa acatgagccc atcacagtac 2731981 aggcttgcgg tgttcagatc atgaaaaacg ctgacagctg ccaatccgct ttctctcgtc 2732041 aggcgtttga tcagatcaag caggtctttt tgataagcca gatcgagaaa attagtcggc 2732101 tcgtccaaaa ataaaatacg cggctgctgc gccaaagctt gtgccaaata cacccgctgc 2732161 tgttcccctc cgcttagttc gcgaatcggc ttttgcgcaa aatcggccac tcctgtttgc 2732221 tccattgctt cctgtacaat ggcttcaccc ttttcagtct gctgtctgaa cagccccgtt 2732281 tggaatggat atctgccaaa ggctacagtt tcttcgacag taaaggtgaa ggcttgatcc 2732341 attttttgcg gcaggacagc catgatttgc gccagttcct tcggtttata gtccgccagc 2732401 agttttccgg ccagataaac cctgcctttc ttggccggca gcgtacctgt cagcaagtgc 2732461 aaaagcgtgg tttttccgct tccattaggg ccgagaattc caagaaattc tcccttctcc 2732521 actgttaagc tgacattgtt gattaggcgg ctgtcgccgt atcctcccga cagcccttct 2732581 gccttcatca taagcttctc cccccgcgat gctgccgaat taaaataaga gcgaacacag 2732641 gcgctcccgc caaggacgta atgatcccga tcggcagttc aatcggctca atgatggttc 2732701 tggaaagcag atcggctaaa acaagaaacc ctgccccaag caaggcggac aacggcagta 2732761 aatgccgatg gtccgttccc cacaaaagcc ttgtgatatg cggaatcaca aggccgacaa 2732821 agccaatcgt acccgatact gccacagcgc ttcccgtcaa aagagatccg gctattaaaa 2732881 tcatcatctt cctctgctga acgctgactc caagaagctt tgctttatct tctccatatg 2732941 tcatcacgtt cagttccctt ccgtttataa tcaataaaat ggttcccaaa agaaaaaacg 2733001 ggagaaacaa aataacatag ctccagcccc tcattgagac gctgccaagc agccaatgca 2733061 caatcggaag caggttgtct cctgtcaagg cgatgataag agaaataaat gcgcctaaaa 2733121 aagagttggt gatgacaccg gtcaaaatga gggtggaaac agacatcgaa gcatgaacga 2733181 ggcggctgaa gaaaaggacc gccgccatcg tggccagtgc cgcggctaca ctcaaaaccg 2733241 ggagtgtaaa ccctccgatg acaggaaggt gcaaacctaa gaacagagtc acaacagctc 2733301 cgactgaagc accggatgac acacctagcg tatagggatc agcaagcgga tttttcaaca 2733361 atccttgaaa agcggcccct gcaatagaaa gagccgcccc cacaagggcg gccagcacaa 2733421 ctctcggcag tctgatattc atcataatat tagtgtacat cggatcatca gaaccgatag 2733481 agccgccgaa accttgatgc caaaagacac gaaaaacagc gggaatagga atatgcaggc 2733541 tgccgcaaga aattcctaag atgatgctca cggctaaaaa tgagaaacca atgatatatg 2733601 cggcataacg attattcctt aaacgtatcc gggtaaatgc tttccgcaag ttcttcgacc 2733661 ccttcgatca gacggggacc ggaacgtgtc acaagatcag ggtccacatc atatacacga 2733721 tgatgtttca cagcattgat ttcgctccag ccatcgcgtt tttccacagc tttcgctttc 2733781 acaccgtccg ttgtaacaat tgcatcagga ttgagtttta cgatcgcctc gtctgtcatt 2733841 tgcacccatc ctgtctgatc cgcagctgcg tttttagcat ggatgacatt tagcatttca 2733901 ttcataaacg tatcttttcc ggttgtataa atgtcaggat caggagaaac ctcgataaat 2733961 acgcttttct cctcgtcttt tgaaatggtt ttcgcttttt cttgaatatc ctttagatct 2734021 gatttcatgc ttttcacgag ctgatcggct tttttctccg ccccgccagc ttctccgatc 2734081 atttcgattg atttgtacac ctcggagaat gattgtgcat cattgacagt cagcactgta 2734141 atgcccgcgt ccttcagctg tttgatggca tccgctgatg ctgacatgga agactcatgg 2734201 gccagaacga gatctggttt tagagaaatg actttttcaa cgtttacatt catatctccg 2734261 actttctcaa cctttttgac ttcctttgga taggtatcgt ttgtggtgac accgaccact 2734321 ttgtcaccaa ggccgagtgc gtatgtaatt tctgtgttgc tcggcattaa tgaaacaatc 2734381 ttttttggct cttttttgat ggttacatct tggtttgacg catcatcaat ggtgacaggg 2734441 aacacttctg ttttttgttt tgcctttgaa tccttctgat ccgcaggatt gccgcagcct 2734501 gccagcataa cagcagccaa cagaagcgca gcccatatcc cggctcgttt tttcataatc 2734561 ttttcctcct aaacgaacta aaaaagcatc tctacgacgg taaagatgct gtaaacaaca 2734621 caaaaaagcc tattgtttac acatcatctg tcctcgcaga attcgtgctg atcaaacagg 2734681 caggtatcct ggctcttggc gcttggccaa ttacagtggc gggaccgcac cggcttttac 2734741 cggtttccct tttaagccgg ctgttgttca cggaccggca cctatttgac attcgtatcc 2734801 gtttttcgga gtaattatac tatatgactg acaggcttgt atatgtgtcc tgaatgactt 2734861 ttccccatat tgtgtatgga agcaaaatcc tcgtaaacac taaatttgat cttgtatact 2734921 taataccatc atctatcaaa aggaatgatt cttatggatt tacagctaaa agaaaaactc 2734981 gtcttaatca ccggctcgac gtccggtatc gggaaagccg ccgcaaaaag ctttctgcaa 2735041 gagggtgcgg cagtcattgt caacggacgc aaacaggaga ctgtcgatcg caccattgaa 2735101 gagctttctg gctatggaac agtgcacggt gctgctgccg atttgtcaaa aacagatgaa 2735161 gcagcggctt ttatcgaaaa agtaaatgaa atcggtgata tcgatatcct tgtcaacaac 2735221 cttggtttct tcgaggtaaa agacttcgcc gatgtgacag atgaagagtg gaatcaatat 2735281 ttcgaagtga acgtgatgag cgccgttcgg acaagccgtc acttccttcc aaaaatgctt 2735341 gccaaaaaca gcggccgcat tttaaatatt gcaagtgaag caggcgtcaa accgctgcca 2735401 acgatgattc catactcaat gacaaaaacg gcactgatca gcctttcaag aggaatggct 2735461 gaaatgacaa aaggcacaaa tgtgacggtc aactcagtgc tcccgggacc tacttggaca 2735521 gagggcgtgg cctcctatat ggaaggcgcc gcacaagcag ccggacagga tacagataca 2735581 tttatcaaag actatttcaa ggtcaatgag ccaacctcac ttattcagcg atacgcgaca 2735641 gcagaagaag tcgccaacac aatcgtattc ctcgcgtctg acgccgcatc cgccattaac 2735701 ggcacggcac agcgtgtgga aggcggcatt atccgttctc tgtagtataa aaaaacgcat 2735761 ccgtgtttcg gatgcgtttt ttttatacgt ctccagcaaa tggtaccggc tgatatccgc 2735821 ctgtttccag ttgtgctgaa aacaaccctc cagcgtgagg ctgctcgtat ctctcttttt 2735881 ctgtcatttg ttctgttgcc gttgtaatgt aaagggtttt taagtctctg ccgccgaacg 2735941 cgcagcacgt gacatattta gccggcacgc tgattgaatt gatttctttt ttctgaaacg 2736001 ggtcaatgtg aacaacgcgg ctgccgccaa acagcgccac ccacagcatg ccattttggt 2736061 caattgtcat gccgtccggc aatccgtctg actgatcaaa acgatagaca ggttctggat 2736121 tcgaaacatc tccgctttga ggatcatagc tgtaacgtac aatctcctgg gtcggcgtgt 2736181 cgatgtaata catcaaattc cgctcgcggt cccaatccaa accgtttgag gtggagactt 2736241 gatccttgat tttgacaaga ctgccgtcta gattcaaacg gtacagcgac gcctgttttt 2736301 gctcgccttc catgctcgtc gtccccgccc aaagccttcc gtacgggtca catttagcat 2736361 cattaaatct caggctctca tgcatgtcct tcggctgttt aattttttcc aagctgtcat 2736421 cccgaagatg atacaggtaa aacccgtcct tcatcgtcat aatcagttca tcctttgaat 2736481 atttcgcaag cgccgtcaca aaggatttga atttgattga tcggttgatt ttttcttcag 2736541 ggtcaaagat gtggagctcg ctccccagga tatcaaccca atataagcgg ccgttctctt 2736601 catcccataa cgggccttca ccaatcactg cccgagtgtc tgcttccaat actgcatcca 2736661 tgtgttacac ctctttagct tcagtctata tattgttatt cccggcaaag aggtgtccaa 2736721 accacttgat gtttattgtt ttttaaaaag gatggtaatg accgttccaa tgttcgttct 2736781 gctgttcaca tggatcgttc cgttatgcag atggacaagc tccttggcaa tcgcgagccc 2736841 gagacccgtt ccggcagttg aatcttttgt gttcgtccct ctgtagtagc ggttaaacaa 2736901 atgggtgatc gtttcttcat ccattccttt cccattgtcc ttcactttta aagaaatatg 2736961 attttttgtt tgctccagaa tgacttgaat ctctgttcct ttgccgttgt gcttcacggc 2737021 attcccaagg aggttttcta atatgcgcct gaaccacgct tcatcaaggg caaattcaat 2737081 atgctcttct ttggatacaa acgagatatc atagccttca gaaaacggat ttttcttaaa 2737141 atcctcaatg acatttttaa aaaacgggat aaggctagtg agctttctct caataggaag 2737201 agcatcattt ttcaggcgat acgttaaatt taagtcttca atcagcttag acatgtattc 2737261 agatttttct ctgacaacct gccccatttc tttcacttct tccggcgacc agtcatactg 2737321 cttcgactcg agcatcatgc tgtagccgta aatgctgctg agcggtgttt ttaagtcatg 2737381 tgacaaaccg gcaatccatt cttcccttgt cgcctggatt ttttctctgt ttcttttatc 2737441 ccttctcagc gtttcagtca gctgatccat tgattcaaat atctcaccga agaagcggta 2737501 cggctgtttg atttttccct ttttattttt gctgacagga cggccttccc ggtttctggg 2737561 ctcctcaagc ttcccttttg acagattgac cagccatcta atcgtgtgaa aaatcggcag 2737621 cccgaatcgg aacatatacc aaacggtcat ccaaatgata tacatgaaca aaacggccat 2737681 cacgagaaac atcgctttta atacaacctt caggaatgat ttgttaaact cctgatcggt 2737741 tacatagact gggttcggca ccgtagcgac catccatctg tctttattga ggatcttaac 2737801 ggaaatttcc cgcttatagt tccaaggctt agagctgtat ttaagcagct ccagctggtt 2737861 catcgttttt ctctcgcttt ttgtgctgtt gatgctgtcg agaatctttc cattgctgtc 2737921 taacaggtaa atggcgcctt ttttccgttt aatatagtcg atggtactag acttatagtg 2737981 cgctagtgag tctatctttt gttcacgctt ttcaacggaa gtcaggagct gttcactttt 2738041 tgatttccag ccggacaata gaagatacga cttatcttca atattgatgg cccaataatt 2738101 cagtttatag ttatgaagct ttttggtttt ataaatagac aaaagctctt tcttggtata 2738161 ggtgcccggc acgtcttttg gcacgccgta ggaataatca gtgtttcctt ccgaatcaat 2738221 gatttgcatc cagccgtgct gtttatcaac agatttcttc aggaaattat ccacttccca 2738281 tgtcccgtct tcgtttacat cgagatatgc ctcaagtgtg tcggtcgttg ctttcgtcag 2738341 ccctgaattg gattccgcat cgctaaaacg ggcgtctaaa tagaaaaacg atgcaacaag 2738401 cataaccgta agcagcagga tcacaatcag catctggccg aaaaagtgaa acaaaaactt 2738461 ccatcttaac ctcatgaccg cttgccttca ggatttggga taaaacgata gccgagacct 2738521 cgaacggtta caatatactc cggattgctc ggatcgcgct caatcttctc cctaagcttg 2738581 cgaatatgaa ccatgacggt gttgttgtca ccgtaggaag gatagcccca tactttttca 2738641 tatatttgat ctttggaaag caccacgtta gggtgttcac aaaaatactg caaaagctgc 2738701 agaagctggg ctgaacaggc aacggcttcc ccgcctacga tcaactcggc attttgcgga 2738761 gaaaaagtaa agtaatcata tgtgtaggtt tgatttgaac tcgtttcttt cgattgatat 2738821 gtacgcttga gatgcgctct gatccgcgcc gctaattcca gcggattaaa tggttttgtg 2738881 atatagtcat cagctccaac cgcaaagccc gataatttgt ccgcgtcgga tgatcttgcc 2738941 gtcaggaaaa aaatcggagc gtctgaatac tctctgatca atgtgcaggc ttcaaaaccg 2739001 gacattccgc ccatcatgac atccagcaca atcaagtcaa ccttattggc cttcacaacg 2739061 ggaatcgctt cttctgcgct tgccgcatcc agtatatttc gataaccttc tttttcgaga 2739121 acgcgtttga tcatgtccac aatcgctttc tcatcgtcta cgattaaaat tgacgcattt 2739181 tccactttta tgttcctttc tgtcactgtt tttttcatct tatcattata tcgtttattt 2739241 atggtacatt tttgaataca ttggagcctt ggcaaatcaa aacagcaaaa aaggagcaaa 2739301 caagcgctcc cttttgatgt tttttcatat gaaaatatta tgagttctca tctaccatgt 2739361 acaaaataaa ctcccaaaac cccggtacat cctgacataa aagcatatca gccttttcaa 2739421 acattttgat cttcagctct tgctctaaat cttctctttc ttgataggac gtattgctga 2739481 gtttttttct gatcatcggt gaaaagcatg caatcaggtg ctcaatgtca taagtctcgt 2739541 ctttttgttt ctttttttgt tcaaactggc cgtccacagc ttacttttcc cccttttttt 2739601 gcgccgctaa ctgctttctg atattctcca gccccttttt atgaatgttg gagatgtttt 2739661 gtcgggactc ccctaatgaa tctgcaatct cctgcatcgt ggcaccgtga agatagactt 2739721 tcgtcagcac acttttttgt ttgtcagtca gcttctggat cgcttggtag agctggtaat 2739781 cctgtacatg ctggctcaaa tcatcctgcc tgtctaaaaa ttcttcaaat gcatcgctac 2739841 ctgtttcgga agaaagccga tctcccgcct ccggatgatc aaccgtcagt ggataccgtt 2739901 tttggttttt gcgaacccgc ttatcaaaat caatagaaaa gatgcgaatc attgaattca 2739961 tatacttgac gatgcggatt tctttataaa attgcttaaa tagctcgtcc aatgatcttg 2740021 catctttttc gttagggctt tccattacgt ttttgaacaa acggtaatgc tgaggattgc 2740081 tcaaaaaatg cttcacgatg ggatgcttca ttatctcctt acattttgac cgtaaaagac 2740141 tttgatagtc catcaaaccg cctccctact aaattaaatg aaggaaagca aaaaaaagta 2740201 aactactact ttccgcctag tgtcttccaa aatactttgc agcagtttac gttttatcgg 2740261 ttttcctcac ttacatacat gactgcagaa aaagaaggga ggtattttcc tatggatcag 2740321 gtttttatag aggaagtcgt aaaacagatc ggcaatttgg ggtttcccgc gctgattgca 2740381 atgtatctgc tgacccgatt cgaaaagaag tttgatcaac taatagaact aatgacagaa 2740441 ctgaaagatc atgcaaaaaa ataatttttc aatcgaagtt gacttttcac tggttttttt 2740501 cacttaacaa aacagaaggg aaaacgaaag gcctttcacc ttctctttct gctatcacat 2740561 ttaaatgtaa ggaggaaaca tttcatgaaa aaacaaaatg acattccgca gccaattaga 2740621 ggagacaaag gagcaacggt aaaaatcccg cgcaatattg aaagagaccg gcaaaaccct 2740681 gatatgctcg ttccgcctga aaccgatcat ggcaccgtca gcaatatgaa gttttcattc 2740741 tctgatactc ataaccgatt agaaaaaggc ggatatgccc gggaagtgac agtacgtgaa 2740801 ttgccgattt cagaaaacct tgcatccgta aatatgcggc tgaagccagg cgcgattcgc 2740861 gagcttcact ggcataaaga agctgaatgg gcttatatga tttacggaag tgcaagagtc 2740921 acaattgtag atgaaaaagg gcgcagcttt attgacgatg taggtgaagg agacctttgg 2740981 tacttcccgt caggcctgcc gcactccatc caagcgctgg aggagggagc tgagttcctg 2741041 ctcgtgtttg acgatggatc attctctgaa aacagcacgt tccagctgac agattggctg 2741101 gcccacactc caaaagaagt cattgctgcg aacttcggcg tgacaaaaga agagatttcc 2741161 aatttgcctg gcaaagaaaa atatatattt gaaaaccaac ttcctggcag tttaaaagat 2741221 gatattgtgg aagggccgaa tggcgaagtg ccttatccat ttacttaccg ccttcttgaa 2741281 caagagccga tcgaatctga gggaggaaaa gtatacattg cagattcgac aaacttcaaa 2741341 gtgtctaaaa ccatcgcatc agcgctcgta acagtagaac ccggcgccat gagagaactg 2741401 cactggcacc cgaataccca cgaatggcaa tactacatct ccggtaaagc tagaatgacc 2741461 gtttttgcat ctgacggcca tgccagaacg tttaattacc aagccggtga tgtcggatat 2741521 gtaccatttg caatgggtca ttacgttgaa aacatcgggg atgaaccgct tgtcttttta 2741581 gaaatcttca aagacgacca ttatgctgat gtatctttaa accaatggct tgccatgctt 2741641 cctgaaacat ttgttcaagc gcaccttgac ttgggcaaag actttactga tgtgctttca 2741701 aaagaaaagc acccagtagt gaaaaagaaa tgcagtaaat aaaagacttg cggcttgcag 2741761 agagcactcg ttctctgcaa gccttcataa ggagctgaac cagtgaaaca tcaaaaccct 2741821 tcaaaacgct tattgcggct ctccataaag tacttgctgg ccgcagcagc agtggtgttg 2741881 acctattttg ctgtcatcta tatattgttt tctttagcgg gaacgagcta ccgctcagca 2741941 gctcatgtcc tgctttttgc cgtggtattc cttgttctcg gattatgctt tgaaccattt 2742001 gaacggctga tgatacatag ctttacattt ttcaagacag gaaaacgtct attcattctc 2742061 cttgctggca tcgtacagct gctgtttttg tggatgactg ctcatacaac agaccaattg 2742121 atcagcgaca tctggctgtc caccacagaa gaaatgattg tcgcagccgt ttttttgatt 2742181 ttagacaaat gcaactcggc tcttcccagc taaaaaaaga acgcattcca attggatgcg 2742241 ttctttttat tcatagcgaa gcgcgtctac aggctgaagc ttcgaagcct tgatagacgg 2742301 aagcaagccg aagataatgc cgactgccat tgaaaagatg agtgctccga caacagctgg 2742361 aatggagacg ataaaaggca tcggaaaaat gaccgtcagc agcttggcga tgccgaagcc 2742421 cgccagcaca ccgagtattc cgccaatgct tgtcagcacg acagcctcgg ttaaaaattg 2742481 aaataaaatc acacgccgct tagcaccgag cgctttctta attccgattt ccctcgtgcg 2742541 ctccgttacg gaaacgagca taatgttcat gacgccgata ccgcccacca aaagtgaaat 2742601 actggcgata ccgccaagca gcaatgcaaa tgactgatta aaggactcca cttcctgcgc 2742661 gatctcctga agatccatta cactgtactc tgctttttcc agctcagctt ctgacagtcc 2742721 ctgatttaaa agatctgcag ccattacacc cgcttcttgg atatgctcag aagaatcagc 2742781 ctgcacggca atctgcgttg gcgcgtcaaa tccttcaata agcggccaca cttttttcgg 2742841 cacgtacaaa accgggttcg catagtcgcc ttcaaacatg ctttcctgtt gatttttttc 2742901 tttaaaaaca cccacgacct taaacggcac accattcatc tcaatgcttt tatgcagagc 2742961 ttctccgtct ggaaacagtt catctctgac agcttcattg atcatcacta cttggtgtgt 2743021 gctgtttaaa tcgttttccg tcagctttct cccttcggtt attcggattg gaaacatgtc 2743081 gaagtaatca tcgtccactc catacacttg gggatacgaa acgttagtta aatgaaaaac 2743141 gctcgcgcct tctgacaagt aatataagga taatcctttg accatcggat ctgatttgat 2743201 cgcctttact gtttcttccg ctacaggcgg cgcggacgca tacgacacct gagggccgcc 2743261 gctctcctct tctccgccag acggctggta gacaacattg atggcgttgt ttcccatgcc 2743321 gatcatactt tgctttaact gctcactttg gcccttcagc attgaaacaa tcgcgatgat 2743381 tgccgctatg ccgataatga cgccaagcat tgtcagaatc gatcttaatt tatgagagaa 2743441 aatggattga aaggagattc gaatatgttc aagcatggct gatatcccct ctctcatcta 2743501 ataccaactc tccgtctctg ataaaaacgg ttctgtcagc ttttttggcg acgtccgggt 2743561 cgtgggttat cataataatg gtcttgcctt cccgatgcag ttcagaaaac agtgccaaaa 2743621 tttgttcact tgatttggta tcaagcgccc cggtcggttc atcagctaaa ataaacctcg 2743681 gctgattgac aagggccctc gctatcgcca cccgctgctt ttggccgccg gacagcttag 2743741 gcggtttgta ggagaccctg tcttttaatc cgactttttc cagcgcttca tatgcccgtt 2743801 gccttctctc ttttttcttc actttattgt agatcatcgg cagctcgaca ttttgcagcg 2743861 cggtgagacg cggcagcaaa tgaaaagttt gaaacacaaa cccgattgat tcattgcgaa 2743921 tttcggctaa agccccgtct ttccctttca atatatcgat ctggtcaagc gtataggttc 2743981 ctgaggttgg cctgtccaaa cagccgataa tattcattaa cgttgacttt ccagaaccgg 2744041 aaggccccat aatagctaaa aactcccccg cctgaacggt cagattgata tgtttcaaga 2744101 ttggaacttc ttcttttccc agcttgtacg acttcgaaat attattcagt gtcagcattg 2744161 actgtaacct gctttccttc cttgaccgcg ggatcaggat agatcacata atcttccggc 2744221 gtcaggccgc tcttaatttc caccatgtca ttttcatcag tctctccgat ttcaacaggc 2744281 tgcttaaccg ctttgtgatt ctcatcagct ttccatacgt acggttcgcc gtcatcctga 2744341 atgaccatgt cggacggcag cttgatcgtg tccgcatcag cattatcact catcacttcg 2744401 atgttgacat gatagccgac ttcaagacct ttatggctgt ctaataaaat ggtgaaagga 2744461 tagttagagg actggggatt catttcttca tcagcaaagc tttctgattc ttcaccctcg 2744521 cctgctcccg ctggaagctt gccgatcgag gtgacctttc ctttccactc gccctcaccg 2744581 cctgttttca gcgtgaccct gactttgctg ccttttttga tcgtgtccat taacagctca 2744641 ttgatttggc ttttgaccag atatttgcct gtcgaaacaa tctggatata cgggcctgct 2744701 gcctggtcgc ctgttgcacc gtcagcgata tcctgattga cgctttgaac gattccgtca 2744761 tgcttgcttg taatgacatt ggaacctttg tttttcgtca ggccagccag ttctttttga 2744821 tgctgcttca gttcaagctg gcttgttttc aaatcgaaat tggtttgatc aagttcatct 2744881 tgaagctggt ttttctcttc ttttcctgca actttcagct ttttttccgt ttccgttatt 2744941 gatttttgca aacggttgat ttgcagattt gtcatttcaa tttgcaaatt ggcttgctcc 2745001 acttcatcag aatgatcctc gccctcatac tcaaaaagct tatcgccctt tttaacctga 2745061 tcgccttctt tgacgtatgt ttttttaatg ctgccttttt ctgaatctat gtatactttc 2745121 tgctgtttct caggttcaac ctttccagaa aacgtttggc ctgattctga atctcctccc 2745181 atgtataccg cgaccgattc agcatagggc tccgatgata cggcaacttg gttcatgtga 2745241 gtaaaaaagt aaaaaccgcc agcgccgatc ccagccaata caagcacacc ggcacatatc 2745301 gcaccgccaa taagccattt tttcttcttg gacacaacga tctcctcttt ctgtaaacta 2745361 tgtaatattt tcgaaacatt ctaaccaata ttatctatta attcaaaaag acttgcaatc 2745421 cttttattga aatgacggaa tcaaatagaa aaattgtatt ttcaaagccg aataaaaaaa 2745481 atcccggctt caaaccggga ttttttcata cagtaactag ctctttttca tttttaatca 2745541 agtcatatgt caagcataca ggtttatttg tacggggatc agtcacgatt tcggcatcaa 2745601 tctgaaatac ctgcttcaaa atgtctggtg tcatgacctc cagagcagtt ccttccttga 2745661 tgaccgtgcc ttttttgagc gcgatcatat aatgagaaaa acgagctgca tggttaagat 2745721 catgaatgac cattaaaatc gtccgccctt gctctttgtt gagtctgtca agcagctgca 2745781 gaatttcaag ctgatgtgca agatcaagat acgttgtagg ttcatccagc agaagcagtt 2745841 ccgtcccttg cgcaagcgcc atggcaatcc acacacgttg acgctgtccg cctgacaatg 2745901 cctcaatcgg ccgttcagca tattcagcca tgcctgtttc ttcaagcgcc catttgataa 2745961 tccggcggtc ttcgtcattt aatctgccga atcctgattg atgcggaaac ctgccgtacg 2746021 acaccaattc gtgcactgtt aggccgctcg gcgcttcagg tgtctgtgga agaatcgcca 2746081 tatcttttgc aatgtccttt gtagacattt tatgaatcgc tttgccgttt aaatagacgg 2746141 cacctgcatg tgaacgcata attctggaca ttgtttttaa aatcgttgat ttcccgcagc 2746201 cgttcgggcc aattaaggtg gtaattttcc ctttaggaat cgatatattt aaatcctcta 2746261 caatcaccct gtcgccataa ccgattccaa gctgttccgt tgataatgaa ttcatattcg 2746321 gccccctcct ctaattcgct ttcatcaata aataaataaa gtaaggcgca cctagcacgg 2746381 aaatgacaag tccgaccgga atttctgatg gtgccaatac atttctcgcc agcgtatcag 2746441 caagcaaaaa caggaatgag ccgatgaagg cggagaccgg tatcagcgtc tggtgacgtg 2746501 gaccggtcag ccttctagcc acatgcggcg cgatcaatcc gagaaacgca atgccccccg 2746561 cagctgccac gcatgaagcg gcaagagtga ccgctgccag aagaagaatc cgtctttcct 2746621 tttcaacagc ggtgcccagc ccggtcgcca attggtctcc gagctgcata atgttcaaat 2746681 agcgtgcctt atataaagta aacagaagca agatcacaat ccaagggaga atcgcccaga 2746741 tcatattcca gttcgccccc catattgagc cggatatcca aaccgcggct tgcataaaat 2746801 catgagggtc catcttgagc tgaaaaatca gcaacagggc gttgaatccg gcattcaccc 2746861 ctatgccgac taaaatcagc cgaatcggtg tcacgccttt tttccatgcc agaatataaa 2746921 tgagaaacgc agcgaggatt gctcctgcca aagcactgaa cggcagcata aatgttccga 2746981 aaaagctaag atctgaagct gacccttgaa aaaagtatat aaaaagcact acagcaagtg 2747041 aaccgccggc gttaattccg agaataccag gctcggcaag ttcattttga gacacgcttt 2747101 gcaaaatggc tccagctacg gagatccctg ctccaacaag caaagaaagg atgatccggg 2747161 gcagcctgaa ctcaaataag acaagttcat cacgcgccgt tccttggccg aaaaagacct 2747221 gaagcgtttt aagcggtgca attttgataa cgcccaaatt gagactgata aaaaagacca 2747281 ccacgataag caaaaaggtc acagccatta caatgagcgg tttgtttgtt tttgttttca 2747341 ttacagccct ctcctttcac gacgtgccaa ataaaagaaa aagggaacgc cgataagaga 2747401 agtcagcgcg ccgacaggcg tttcaaaggg cgcatttacg agtctggccg ctatgtcagc 2747461 aaaaacaagc aaaacagcac cgagcaccgc cgagcaagga atgatccacc gataatccac 2747521 accgaccaaa aaacgggtaa tatgcggaat gatcagcccg ataaatgcaa tggtgccggc 2747581 aatggaaacc gcagctccgg tcagaattac tacaataagc atgccaacca gtttcaccgc 2747641 tgatgtatat tgtccaagcc cttttgccag atcgtcaccg agacttaaca ctgtaacaga 2747701 ccgggcgatg aaaaacgcga gcgttaaacc gacagcccct gcaataagca aaagctggac 2747761 ccccgaccat ttcacacccg ctaccccgcc tgcgtaccaa aagctgatat cctgagcgac 2747821 atcaaagcgg attgcaatgg cagttgaaat gccggtaaag aaataagtaa ctgccgtacc 2747881 cgccagagca agctttacag gcgtaagtcc gccccttgaa aacatgccta tgcccattac 2747941 cgtcgatgcc cccagccccg ctcccgcaaa ggaccatagc acaagcccca ttgcagaaag 2748001 tccgggaaaa aaggcaaacg caatcgaaac cgcaaacgca gagcctgatg tcacacccat 2748061 aatcgaaggc tctgccaaag ggtttctcgt catcccctgc atgattgctc ccgacactgc 2748121 caacaatgcg cctacaagcg cggcagccgc cgttctcgga agccgaagat catgtataat 2748181 ttggtgagat gtctttgtcg gctgataatg aaaaatggcc tcccatacag tgcgcaaatg 2748241 aatatccgct gcacctaggg atatggataa aaatgcgcca aggcaaagca ggcatagacc 2748301 tgcgataagg acgatgaccg cgccatatgt ccttgacgtc cattggattt cttctgatgc 2748361 agtccgtata tttttatgtt gactcaactg ccgtacttcc tttctgttac tgataatgat 2748421 tatcaattgc tgtttcagta tatcactttt ttcagctgat ttaatagagt gttttgaaca 2748481 aaaatgaaaa tgcatttgca aaaatatcgt gtcaaccggc acttgcagtg gtataatcac 2748541 agatgataat gattctcttt ttcatctatc ttttagaaag aaggtatgag atatgaccca 2748601 tatatacaag aaactcggag ccgcgttttt tgccctgtta ttgattgcag cgctggcagc 2748661 ctgcgggaat aactcagaaa gcaaaggttc tgcctctgat tcaaaaggcg cagaaacctt 2748721 tacatacaag gctgaaaacg gaaatgtaaa aatcccgaag catcctaaac gggtggttgt 2748781 catggcagac ggctattacg gctacttcaa aacactcggc atcaacgttg taggtgcgcc 2748841 tgagaatgta tttaaaaacc cttactacaa aggaaaaacc aacggcgtcg aaaacatcgg 2748901 agacggcact tcggttgaaa aggtcattga tttgaaccct gacctgatta tcgtctggac 2748961 aacacagggc gctgatatta aaaagcttga aaaaattgcg ccgactgtcg cagtaaaata 2749021 cgataagctc gacaacatcg aacagctgaa agaatttgca aaaatgacgg gaactgaaga 2749081 taaagctgaa aaatggctgg ccaagtggga taaaaaagtt gcggccgcta aaacaaaaat 2749141 caaaaaagcg gtcggtgaca aaaccatttc cattatgcaa acgaacggaa aagacattta 2749201 cgtatttggt aaagactttg gaagaggcgg aagcatcatt tacaaagacc tcggcctgca 2749261 ggctacaaag ctgacaaaag aaaaagccat tgaccagggg ccaggttata caagtatttc 2749321 attagagaag ctccctgact tcgccggaga ttacattttc gcgggcccat ggcaatcagg 2749381 cggtgatgat ggcggcgttt ttgaaagctc catttggaag aacctgaatg ccgttaaaaa 2749441 tggccatgta tacaagatgg atccgatcgg attctatttc acagacccga tttcattaga 2749501 aggacaactg gagtttatta cggaaagctt gactaaataa acaaaagagc cgcctgcccg 2749561 cggctctttt gcttatttat aaggaacggc tcaatttgaa tcatatcgga tattttcttt 2749621 gagccattca tattaagctg catcctcatc acgatcagtt tttttatgct ggagagactg 2749681 aaaaacgttt tttgcatatt taacgaacgg attcctaaca ggagaaattg tgattttata 2749741 aaaaagacac ctgagcaaat caggtgtctt ttcattatgc ttgtttttct ttctggaact 2749801 tgttactcac aaatggataa acgattaagc cgacaaagaa taaaccgatg ccgagtataa 2749861 atgtcgttaa atctgctgtg cctgttacga taacaaacac ggagtatgca cacgccagta 2749921 tcgcgatcaa tccgtctctt acacgggagc ctttcagctg gtcatacgtt tcacctttga 2749981 tgactacctt caagctgtag attgcagata ccagatacgg aattaaatat gcgagtgtag 2750041 ccgctgtcgt taaaaatgta aatgcgtcac ttattgtccg ggaaataacc gagaaaatga 2750101 agacctgtga catgacgttt gtaataatga gtgcaatgac cggacttccc tttttattcg 2750161 tttttgcaaa aaatgccggg aaatctcctg ctttagcggc ttggtatggc acctcagagc 2750221 caagcaaaat ccagccgagc atcgttccga ataaacaaag gatagccaaa agcgccataa 2750281 tcacgcttcc cgcgtttcca acaatcgcat agagtacatc aacaaatggt ttttcagagc 2750341 cgacaagctt atcatgcggc agaacaccca tcgtaattaa agtcacaata atatatatgc 2750401 tcaaggcaat cagcaagccg gtaattgtcg cacgtttcac atcacgctga gagcgcgcac 2750461 ggccggacag gatcaccgcg gattcaattc cgacaaacgc ccacagtgta gaaatcgcag 2750521 cgttatgaac ctggccacca attccaatgc ttgtgccgtt ttctccttga accgggaaat 2750581 aaaaatgacc gaataatgac gtttgaaaca caaacaaacc ggcaacgata aagaagacaa 2750641 aacctaatac tttagaaagc gttgtgacaa agtttaattt acttgcgccg ttaatgctgg 2750701 caacaagaat cgcgtgcgtt ccccataaca agatcgtaca tacggcaaac gtcagtaatt 2750761 ggccgagtgt cacctcttgc ccgccgatcg aaaacatctc acgtttatca accaagatcg 2750821 ggaagaacga agtcaagtaa ccggcgagac ttgtgatgat cgccacgtta ctgatccagc 2750881 tcgccaccca gtagccccac accattgtga aaccggcagc gttgcctttt ttcgggtcag 2750941 aaaacagcgc tcttgcataa ctttgcggtc ccgctgtcag ttcaggcttg cgaatggaca 2751001 agtgtccgaa cacaagtgca atcatcagca cgccggcacc tgtcaaaagc caggcggacg 2751061 tagctccaaa cggactcgca attgaagcaa gcgagctcgg caaggagaaa attcctgatc 2751121 caaccatatt tccaacgaca aacgccgtta ataaccaaaa accccatttt tttgtctgtt 2751181 ccattccagt acctccatga ttctttgtac ggaccagacc ccgagatcat ataaacgcaa 2751241 aaaaagcctg aacaaaagtc catgcttaaa gaaacacaca cccttgatct ccggatagcc 2751301 ctccgcgaaa aagcacgcgg cagtcctgca cttattcaga tacagtccca gcatagagaa 2751361 ggatcggctt tctccacact tcggcgctga tgccttttac acatgtttaa cagcccctgt 2751421 cagcctagca tgtgtgactc atcatccgcg caacctctac ctcactgaga aagagtgagg 2751481 atttaattat tcagttactc ccagaaggtt atcaaagaaa ggatgatctg tcaaagggaa 2751541 cagatggaaa atacggatag agccaagccc tatccgcatg tggttatcga ttatttttct 2751601 ttttttgcac agcttcttga agcggatcat cttttagagc tgaaccagca tcttcaagag 2751661 ctccttggat tacgtttttt tctttttcgg aacgttttcc tttatcttta ttaaagaaac 2751721 ccattcgtat cacctctttt aaaaaatagg tacatgttta agatgccttt ttcctgaaaa 2751781 attatgcggg atatttttta tcgtccaaag tcctgttgat caaacataca ttctcttgat 2751841 atatttgtaa ttcagagatt ttttgcaaaa gataaaagga gaagcggcaa atgacaggaa 2751901 aaacacacat catgggaggc atcgcttctt gtacggcagc ggcttattat tatggatttg 2751961 atccagtgct tatggctgcg tcaggcgcgg ttggagcatt aatacccgat atctgccaca 2752021 cacaaagcaa aatcgggaga aaatttccta ttttatcgaa agtggtcagc tccgtttttg 2752081 gccatcgcac ctttacacac agcctgctgt ttatgctcat catgtttttt atcacttcta 2752141 catacattcc agataaaaac atatcagccg gcctgatgat cggaatggcg agccacttga 2752201 ttcttgacgc ttggacggtg aacggaatca aattattatt cccttccacg atccgcgttc 2752261 ggcttccatt atatatgaag acaggcagtt tttctgagca gctcgtgcta gccggcctga 2752321 cccttgcttc atgttactac ttttatatgc tgtttcatgg ccgcatgttt taaacatgag 2752381 tgctgagact tgtctgaacc ggctgttttt agtaggtttt acttaagaag catttcatgc 2752441 agatgatcaa gaaaacgtga ggagtcatat tgatgaaagg aacctttttt cacaatcagc 2752501 ggtttttatg tttttcgatc ttatttatgt ggatcaaaac gtatgtgata tataaactcg 2752561 gctttgattt gcaaatcgat actctgttgg aggagctaat gctgctggtc aacccgctca 2752621 gctttattct tcctttattc gggatcggcc tgtttctaaa agaaaacaag cagcgggcct 2752681 ttttgctgat tgccaatttg gttctgactg ttatcttgat ctctaatacg attttttacg 2752741 gcttttatat cgattttatt accatcccgg ttttatttca ggccagcaac atgagcgata 2752801 tgggcagcag tgtaaaagaa ctgttccatc ctctgtttat cgccctgttt gtggatttgg 2752861 tttttctgct gttgttcgcc agaaaaacca aacacccaca gacaaaagcc gctccccaca 2752921 cgatcaaacg gtactatgca gcttcctgcg gaatgctttt atgcacactg gcacttgcag 2752981 aagtacagca gccgaagctt ttggcacatt cttttgaccg ggaaatgcta gtcaaaagca 2753041 tcggcctgtt tcagttccat atttacgata caatttctca gactgttaat atcagcgcga 2753101 aagcttttgc cgatgaagac agtataactg ccattaaaaa ctacacagag gctgattaca 2753161 gcaagcctga tcaaagcaaa ttcggtcttg caaaggggcg caatgtcatc tttgtaacac 2753221 ttgagtcgac ccaaagcttt gttctgaatg aaaaagtaaa tggaaaagaa attaccccat 2753281 ttatgaatga tctcataaaa aaaagctatt cctttgatca tttctatcag caaacagaac 2753341 aaggcaaaac atcagattca gaatttatcg tcgctaactc actgtatccc tcccttagcg 2753401 gcgccgtctt tttcacgaaa agcgaccatc aatttcatac gatgtataaa tcgctgaagc 2753461 agcacgatta ttattcagcc gtctttcacg ctaaccataa aacattttgg aacagagatg 2753521 tcatgtacga tacatttggc attgaccgct tttttgatgt tgatgatttt catgtcactc 2753581 ccgggacatc gacaagctgg ggcttaaaag acaaagaatt tttagagcag tccgccaaaa 2753641 agctgaaaag cctaccgcag ccgttctaca gcagttttat cacgttaacg aatcattttc 2753701 cgtttgagat tgatgaaaag gatcagctga tagatgaatt cgattcaagc agtgatctgt 2753761 taaaccgcta tgtgaccacg gttcgctatg aggatgaagc attgaagcat tttatcaaaa 2753821 aactgaagga cgaaggctta tacgaaaatt cgatgatcgt atttatggga gatcattacg 2753881 gcatttctga agcccataac gaggcaatgg ctgagttttt agggaaagac gaaatcacac 2753941 cgtatgacaa cgttcagctc cagcgggtgc cgtttatcat acatatcccg ggaatcaccg 2754001 atcaacagcc ggaaaccatc cctgatgccg ggggacaggt cgacgtcagg ccgacgctga 2754061 tgcatttgct cggcgttgag acaaaaggcg atatccaatt cggcaatgat ttgctgtcgg 2754121 gcgaccgcac cccattcgcc gttctgcgaa acggcagctt tattacgaac gattatgtat 2754181 acacaaagaa cacgtgctat agccaaaaaa caggtgaagt gctggaagat caggatgcgt 2754241 gcctccctta caaggagaaa gcaaacgaag aactgtctct ctctgataaa attttaaatg 2754301 gtgacctgct caggttttcc gaatgaaaaa atccctctat caagagggat tttttacgtt 2754361 tccaatatca ccttgccagt cagcttcgtt tcatagccgt ttaaatgaga cagattcgcc 2754421 ttgtagtcct cagaattcaa aatctccttc acggctttga gcaactgctc attttttttc 2754481 aaaacaacga tatcatattg ttcgtcgatg agcgggataa aatcaacact gcccatatgt 2754541 gccgcgtgct gtgccccgat tcccgcgtca gcctgtccgc ttgaaacttg tgaagcggca 2754601 gcgtaatgat cagtcacgat atcgccatat cccactacat cagccggatt cacaccaagc 2754661 aagccaagct gttcatcaag gagcaccctt gcgccagaac ccttttccct gttgatgatc 2754721 cggatatcgg ctcttttcaa gtctttccag ccttgaatgt ttttcggatt ccctttttgc 2754781 acatacagtc ctgctttgcg gagaacgaca ttgatgagac aaaacggttc acctgtcaaa 2754841 atccgtttta cataaggcgc gttatactgg cccgtttctg catcgtacaa atggaggctg 2754901 acaatgtcac acttgccttg atacatatca atcaggctgt ttaagcttcc tttgtattta 2754961 cggagcggcg tctcctgaat ggcattctcc aaatgcttgc tgaggatatc catcgaaatg 2755021 tcctgtccgc tgatcatgac atttggtctg ccgtccggct cagcctcctg cacctgtttc 2755081 ggcgcttctt ttgcagcgat gggctgagac attctcatat tcgttttata ttgctttaaa 2755141 tcttcttcat ccacacgcat ctgccttccg acacggtaag caggcagcac gcctttttta 2755201 atcaagtcat aaacggtcag ctttgatacc ttcagcagac ctgcaacttc ttctatcgta 2755261 taggaagagg tttcattcat catcatcact ctcctatttt attatacctt ttcgccgaat 2755321 gtaaaaaaac ccacataaac caaacataat cagttataat tagttatatc taatgataag 2755381 gggtgcaatc atgtttaaga agtattctat tttcatcgca gccttaactg cttttctgct 2755441 tgtagcaggc tgttcttcaa accagtcttc aacggacagc gagaaaaaag taacgttaac 2755501 catctcagct gccgccagcg cgcaggatgc acttgaggaa atccaaaaaa attatgaaaa 2755561 agatcatcaa catataacca tccaagataa ctatggctca tccggcgcct tgcaaaaaca 2755621 gatttctcaa ggagcaggag cagatctgtt cttctcagct gctgaggata aatttaaaaa 2755681 gctggtggat gatggagata tcgcaaaaaa agacagcact gaattagtcg gtaatgaaat 2755741 tgtgctggtc gtaccgaaaa acggagattc acctgtgaca agcttcagca atctggctga 2755801 atcagaaaaa atcgctcttg gcactccgga atccgtaccg gcaggagctt atgggaaaga 2755861 atcactgaca aagctgtctt tatgggacaa agtgaaggat aaaattgtgt atggaaaaga 2755921 cgttcgccaa gttctttctt atgttgaaac cggcaatgta gacgcaggtg ttgtttataa 2755981 aacagatgcc ctagtctcga aaaaggtcaa cattgttgac gaggcaaaag cagatacaca 2756041 cagcccaatt gtctatccgt taggaatcgt aaaagataca aaacaccgta aggaagcgaa 2756101 ggaattttac gaatacctgc aatctgatga agcaatgaaa gtatttgaga aatatggctt 2756161 tactgccgag tagcataagc gcttcagaat ttttcacacc cgttgtgctt tcctttcagg 2756221 tggcggcagt tgccggaatt gttgtcatta ttctcggaac acttgctgga gcatggatgt 2756281 cacgggcatc atttttcgga aaaacggcac tcgaaacatg ttttatgctt ccgctcgttc 2756341 ttccgcctac tgttgtcggt tttattctga tcgtcatttt cggaaagcac agcttcatcg 2756401 gacaagccat cgagtggatt ttccagcagc ctgtcatttt cacctggtgg gccgctgtga 2756461 tcgcctcggc tgttgtagcc tttccgctta tgtatcaatc agccaaaacc ggatttgctg 2756521 acattgatcc cgatatacaa ggtgcggcaa tggtagacgg cgctagcaga tggaaagtgt 2756581 ttatccatat ctccgtcccg cttgcctatc cttcgttact gaccggaagc atccttagcc 2756641 ttgcgcgggc gctcggagaa tttggcgcaa cactcatgtt tgcaggaaac atccccggtg 2756701 ttacgcaaac actgccgacg gcgatatatg tcgcattgga ttccggcaac aatacccttg 2756761 cttgggcgtg ggtcgtctgt attgttgtca tttccttttt gatgctgttt ttcattcaac 2756821 agaaaaaaac gcactaaaaa aactccccat aacggggagt tttttgatta aaacagaagc 2756881 tcatcaggat ttggaccgac acgctcatct ttatttaatg cgtcaatttt gtccatgtct 2756941 tcttgagaca attcgaaatc aaaaatatca gcgttttcga tgatacggtg ttctttaatg 2757001 gattttggaa tggttacaac tccatgctgc agatcccagc gcaaaatcac ttgagccaca 2757061 gatttattgt gtttttcagc aatctgtgtc agtacttcgt tatccaaaag ctgtccctgc 2757121 atgagcggag accacgcttc cagctgaatg ccttgccctt tgcagtaatc tcttaattct 2757181 ttttgcgtca agcgagggtg aaattcaact tggttcacca tcggtttgat ttcagcatct 2757241 ttcaacagct cttctaaatg atgaacttgg aaattgctga cgccgatcgc gcgaattttg 2757301 ccgtctttgt acagcttttc aagcgcgcgc catgtatctt tatatttatc tttgccaggc 2757361 caatggatca aatataaatc taagtaatca agctgcagtc tttctaggct tttttcaaag 2757421 gcagcaagcg ttgtttcata gccttgatct tcattccaca cttttgatgt gatgaagagc 2757481 tcttctcttg ccacaccgga ttctttaatc ccgatgccaa cgccttcttc atttttgtag 2757541 atcgctgctg tatcaatact gcgatagcca tttttaattg ccgctttcac tgattcagtc 2757601 gcttcattac cattttctac tttaaaaacg cccagaccga accaaggcat ttcaactccg 2757661 ttatgtaact ttacagtatc ttttaaactt gttggcactt gaacctccac cctttcactg 2757721 aaatgtaagc gtctatatta tctcacattc ctctcagccg ataccaataa tacgcttaag 2757781 accctctttt tgcttctttt ttcacagcac aggcaaatcc aaacactatt tttttcctat 2757841 tttaacaata ttgagattac aaatacattg agcagggtat gcgtgtagtg taaccaaatg 2757901 aaaacaaagg aggaaacaac ttgaaacgta ttcgtatccc aatgacactt gctcttggtg 2757961 ccgctttgac aattgcccct ttgtcctttg cttccgctga agaaaatcct gctccgaaga 2758021 tgtcgcagac aactactgct ggaacaactg ccgctgatgt aggtttaaac gtcaacctgg 2758081 atgtacttgg aattgccaac cagatcgctg atgccatcaa atccgcacag aatagggatg 2758141 gctttgtgaa aaacctcatg gagtcttcct tctacgcgtc cggccaaaaa tataacgtca 2758201 tggtctttaa tttaagccag gaatatgaag atcatttgaa cggtgtgcaa ttttacggct 2758261 cagccgttta cgacggcatt acgtatggca tttgggtatt tgaagatgga acctttacaa 2758321 acaaaggcga tggcggctgg atcaactggg ccttcagagg ctggttcgac cgggatggca 2758381 gcactgtcgc atttcatcgc ccttaatata aaaaaagctg gcgctctaac gccagctttt 2758441 tttctgcatt tattcgccgc cttcaagcat ggcggcttcg acatcattaa tgtattggcg 2758501 aagctcatgg gagatgtccc gggaaatttc cctctcttcg aagagcgttt gaatttcatt 2758561 tctgatcgcc tgcacagcct tcagcttcac ttccagcttc tgattttcaa aatgggcact 2758621 tgattttaac tcatgatggc tgtgctccag cctgaaaatt aactgcttat agaatgtaat 2758681 gacagataaa aacacttctt tatgctcatc cgtcttatgt ttttccagat attctatcgc 2758741 tgcttttgcc gttttcactc ttgttgcccg tatcaatccc gcttcattta aaatcgacat 2758801 ctccggcttt ttatgttcac cgaagaaaat ccaatacatc agcctcttga gccttgtttt 2758861 tgataacccg actttaaacg ggttggcata caaaatttcc aactcgttaa atcgttcttg 2758921 cagcacattt gctgtttctt ccgggatgtc tccccgctcc agcattttca tcagcgcctc 2758981 ttgctcagcc ttaaccccct gcgcacggac ttttcgctcg tgcttcttaa tgcgattaga 2759041 tgatgtatac tgctgaaaac gaagattttt cattttctca ttgtattcag ctatcaccgc 2759101 aagagaggcc gttttgtttg tctcattcat gtcctcttta atcgtttgaa gggctgtttt 2759161 gatcaacttg cgtctcgccg tcagcagctt cttatttcgt tcctcgtcct cttcttcttt 2759221 ttcagtcaga attggcagca caacggtggc aatgacaagc gtgcataaaa tgacgccggc 2759281 tgctaaaaag agaatcagat ttctttccgg aaacggcgta ccgtcctcca ggaaatacgg 2759341 aatggaaaaa gaacctgcaa gcgttactgc tccacgcaca ccggaaatcg aaattaacag 2759401 cgtcgaacga agacccggtt tatagatgtt ctgatcttta ttaaagaacc atttgccgtt 2759461 ccagaagaac agcacccaca ggaatctaag gagcattaat gtaaatgtga tgactaggat 2759521 atagccgatc accttcatgt tgctgatggc agtgtcgtta aagataacag aaataacatc 2759581 agggatttgc gtgccgagaa taacgaagac caggccgttc aaaataaata aaataatgtt 2759641 ccacgtactt gaggagacga tttgcagctt gatcatcgtt gattccagac gatcctgttc 2759701 aaccgcatgg gtaataccgc cagctacaac agctaaaatg cccgaaacgc cgatttcttc 2759761 agctgccaaa taaatcacaa acggcgtcag aatttgaatc agcatatgca tcgtgacatc 2759821 ctgcatgcca aggcggcgca gaaataggcg aaaacgaata atcaaaaatg aaatgacaac 2759881 cccgcacagc aagcctccga gagaaataaa gacaaagctg acagccgctt gtgctaatga 2759941 aaatgcacca gtcactgccg ctgcaatcgc aaacttaaag gccaccagac ctgatgcatc 2760001 attcatcagc ccctcacctt ccagcaggcg aagaatccct tttggcattt tcactcttcc 2760061 tgataatgcg ctgacagcga cgacatcagt cggtgaaaga atggccgcaa gtccaaaggc 2760121 cgctgccagc ggaatagcag gaatcatcca gtgaatcgtg tagccgccta caatcacagt 2760181 cgcaaataca aggccgagtg caagcaataa aatcggagcc cttaaattcc aaagctctgc 2760241 ccgcggtgtc ctctttccat cattaaatag cagaggcgcg ataaaaagaa caaaaaacaa 2760301 ttcggtgttt aattcaaaat gaagtccctg tggaaatgag gcggcaagaa tcccaagagc 2760361 cacttgaatc agcggcaccg gaataaacgg aataaaccgg ttcacgatat tagaaatcgc 2760421 aataatcgtt aataatacga gcacaactaa aaatatgtcc aaatgcatga cctccttcgt 2760481 ctgttgtgtg tcggcatgat gagccaaaaa atctgtttgt ctaaaagccc ttgagctagg 2760541 gtggccttgc atccgctatg tggtttcgca ggagttctct ccacacttgt cttcttttat 2760601 agtacccttt ttagggtatt ttttctcatg atatgctcac agtgaacttt tttgcagaag 2760661 agcaaattat agaaaaaaga gacaggaagc tactccctgt ctctcgtctt tctttctcaa 2760721 tcatgaaaat tcgtaccgtc agttgttgct ttaataatgc ccgcgcgaat gacaaagtca 2760781 ccgaaatgct cgccttcctc gcgttctttc gcatagcggg aaagaaggat gcgcagctcg 2760841 cttaaaatgt ctgcttcacc gatgttttca cggtacattt tgcttaaacg gcttccgtca 2760901 aacgcagcgc caagatacat attatatttg cccggcgcct ttccgataaa tccgatctca 2760961 ccgagtgcat gacgtgcaca gccgttcggg catcctgtca tgcgaatggt gatttcctga 2761021 tcacgaaggc cgttttcgtc aataatctct tcaatcttat ctaacagggt cggcaaataa 2761081 cgttctgctt cagccattgc caatccgcag gtcggaagag cgacgcacgc catcgagctg 2761141 cggcgaagcg ctgaatagtg cttgccgtca gttagtccgt actgttcaat taaagcactg 2761201 atttcttctt ttttatcgct tgaaacgttc gcaatcatta agttctgatt ggctgtcagc 2761261 cggaactcac ctgtatgaac tttggcgatt tcccgcaagc cagtcatcag cttataatca 2761321 tcgtaatccg ttatacggcc gccttcgaca aacagcgtga aatgccattt atcctcgatg 2761381 ccttccaccc agccatagcg gtcgccgtta tgatcgaaat gatacggctt cgcttcttcc 2761441 aggctccagc cgagacggtt ttccaattct tcttttacgt tttctaaacc gaggcggtca 2761501 actgtgtatt tgaaccgcgc atttttacgg acagaacggt tgccgtaatc acgctgaatc 2761561 gtaatcgttt tttcagcaac gtcatacatt tgctcaggcc ggcagaaacc gatcaccttg 2761621 gctaattgcg gatatgtcgc agtatcgcca tgcgtcattc ccataccgcc gccgattgcc 2761681 acgttaaaac cgatcagctt gccatcctcg acaatcgcaa tgaatccgag atcttgtgaa 2761741 aagacgtcaa tatcattaga cggcggaacg gcaataccga ttttaaactt ccgcggcaga 2761801 tagagcggtc cgtacattgg ctcgacttct tcctccggcg tgccggcaac tctttcctca 2761861 tcaagccaaa tttcatgata tgctctcgtc cgcggcagca gatcatcact taatttttta 2761921 gaccactcgt atacctctga gtggatttca gattgataag ggtttgatgc acacatgacg 2761981 ttacggttta cgtctccgca ggctgcgatc gtatccaaaa gtgctgagtg gatcgtctga 2762041 atggttttct tcatgttcca tttcagaatt ccgtgcattt ggaatgtttc acgtgtcgtc 2762101 aattttaatg tgccgttccc gtatttctgg gacaggtcat ccatgacaag ccattgttca 2762161 ggcgtcgaga cgccccctgg catacgcacg cgcagcatga actgatatgc gggctcaagc 2762221 ttctgctttt ggcgttcatt tcggaggtcg cggtcatcct gcaaataact gccgtggtgt 2762281 ttcatcaggc ggttatcatc atccggaatt cccgcactga ttcgatcgag catcacttct 2762341 ttcagcgtgc cgcgcaaata atcactttct tttttaatgc gttcaacatc acttggagag 2762401 ccgtccggtg cttttagaat tttggtcacc atgttgaaaa actcctttca agtcaaatca 2762461 atatacatca cgctgatagc gtttttgctg ctgcatatcg gcaagataag cctccgcctc 2762521 ttcgcggctc atattgcctt ctttttcgat aatttcaagc aatgtgttat ggacgtcatg 2762581 cgccatgtgc ttttcatctc cgcaaatgta aacagccgct ccttcttgaa gccattcaaa 2762641 caattctgcg ctatgttcaa gcatgcggtg ctgcacatat actttttctt ccgtatcacg 2762701 tgagaacgcc acatccattt ttgtcagcac accgtctttg agccaattct gccactctgt 2762761 ctggtaaagg aaatccgtga caaagtgctg atcgccaaag aacatccatg cctttccttc 2762821 cgctcccgtc tcctcacgct cctgcataaa cgaacggaaa ggtgcgacgc ctgtcccagg 2762881 gcccaccatg ataatcggtg tttcagggtc tttcggaagc ttaaagtttt gattgtgctg 2762941 tacataaacc ggcagtgtgt ctcccggctg cagtcgttcc gcgcacaaaa tcgagcagac 2763001 gccttttcgt tcacggccgt gcgcatcgta gcggactgcg ccgattgtta agtgcacttc 2763061 atccggattt gcggataaac tgcttgcaat cgaataaagg cgggcaggca tttttcgcaa 2763121 aatcgagaca aactcctgcg cagatacact aaatgggcca tagtcacgga cgagatcaag 2763181 caaatcgcgc ccttcaatat aggcttttac attctcctca tttcccgggg ctaaaagctc 2763241 tctaagctca tcgttccctg tcagctgggc tgcctgttca agaagcggtt ttgtgagaac 2763301 ggtaatctca tagtgagaaa tcagcgcttc tttcagcggt cggacatcac cttgcttatt 2763361 aagcgtcaca atttcttccg ggtcccaatt catttcctta aggagcagct cgacaagttc 2763421 cggatcgttt tccggataga cgccgaggct gtcaccaggc tcgtaagtca ggccagatcc 2763481 ttcaagagac agctccacat ggcgtgtttc tttatttgat cctctgccgt ttaaatttaa 2763541 attttctaac acttcagccc gaaacgggtt tgttctggaa tacgaagact caccggtttg 2763601 tgacgcagcc gccggcgcag gcgcggcgct tccgccccca gcttcattta atcctttcaa 2763661 tacaccctca agccattcgg ctgccggttc atcatagtca agatcgcaat caacgcgcgg 2763721 agaaatccgt tttccgccga gttcttctaa gcgttgatca aattctttcc ctgtctggca 2763781 gaaaaattcg tacgaactgt caccaagcgc caaaacggaa aagcgcaggt cttcaagctt 2763841 aggcgcccgt cttccgtgca gaaattcatg aaacgacagc gcgttatcag gcggctcgcc 2763901 ttctccatgc gtactgacga cgattaaaag attggttacc ttcttcagct gattcggctt 2763961 aaaatcgctc atggatgaga cggtcacttg aaaaccgctc tgttcaagct gcttgccggc 2764021 attttctgca agcccctgtg cgtttcccgt ctgtgaacca taaagaacgg tcacttcttt 2764081 tgaaacggcc ggtgccggtg cttccgctga cacagctgcc gccggcgtac ccgcagcttc 2764141 ttgggcggaa acagattgag cggataaata tccgctcagc cagattttct gggattcggt 2764201 caaggtcggc agaaggcggt taaggagctc tgcctgctcc tgattaaacg gactgttcat 2764261 tacctgaagt tgcaacgtat ccacctcaca aagttataaa ctgatcgaaa attgcatcta 2764321 attgaacttt accggaatac taggcttaag taaaatatat ttacatgatg ataactatta 2764381 agaatcctaa tgataaaacg gctatgcttc atgtaaatag aaaaaagaga aggactccct 2764441 tctcttcatt cagcaatctg atataagtga ggcggcacag cggttacaaa cggactggct 2764501 tcacctgtat aaaataccgc cagcatgtgc atcgcacggg tgcacgcagt atataaaagc 2764561 ctgcggtcgt gctctgtatg atagtgttct tcagatgcat catagacaag cactgcgtca 2764621 aattcaattc ccttcgctaa atacaccgga atcacgcaaa cacccttttg aaatggttga 2764681 ttttctttat gaatcaggcg aacatctgta tattcactca tgtgggcgtg cgcctgtatg 2764741 cattgatgcg cagtcttgca gatgacggct attgtttcgt gccctttttt cttgagccgg 2764801 ccaatttctt gcgcgagctt ttggcaaagg ctctcatgtc cttcagtttt gacaacgagc 2764861 ggcatttccc cgcttctatt aaacggctca atatccgctc catcttgaag catcgctttg 2764921 gtaaactcga caatctgcct tgttgatctg tatgttctct ttaaacgaac atactcagca 2764981 ggctcatcct caaagcacgc atccatacgc tgatccccgt ttatggtatg cgcgtagatg 2765041 gactgattga tatcaccgag cactgtcatg ctggcagccg gaaaaatgct tctcatgtaa 2765101 gccatctgaa acggtgaata gtcctgggct tcgtcaataa atagatgttt gattttcgta 2765161 tttttctttc tgccctcaat cagatcctgc atataaagaa acggtgccgc gtcctcatag 2765221 agcaatttat tatccgtaaa tgccgaacgg gtcagctcac ctatcgcatc catcttctca 2765281 tgttgaaatt ttcctcccca gccagaaaac aattgcaaat aaagttgtgt aacatcaaga 2765341 aatgcaagga gcctgactgc ctgtttgagc ggtttgaaag cttttttcac aatgatggcg 2765401 gcaagcagct gctgctctct ttgataatcg ttaaacgtac tctcgctgaa ccgtttcctt 2765461 tcctgcagtt ttttgtacac gtccaagtag tcctctttgt caagcagctc agcttcatga 2765521 acaacccaat cctttcgccg ttcctttttc tcaagcttgt taagctcact cagcagccac 2765581 ttcgcggttt gctccatccg attcggaatg gagtgatttt gatccaatga gtaaaaatag 2765641 gattgaattt gctcctttgt gatcagcttt tgtccgcgga atataatatt tttaaaaatc 2765701 atcccttcag aggaaagccg tgtgacgtat tcattaatga attgctgaaa ggataaaccc 2765761 gccttccatg tgattcctgc aagccttgtt ggaaaatcgc ctccctttgt ttcggtcagg 2765821 caatattcga gctgatcaaa ggggctttca catttgaact tgcggccaag acgatgctcg 2765881 atatattcct gaaacgtcgc ctgctccata ttctcttctc ctaactccgg caaaacagag 2765941 gagacatagc tgttaaataa gaagttgggt gaaaacaaaa cgatttgtcc ggcatcaatg 2766001 acaccgcggt gcctgtataa caaataagcg acacgctgaa gcgcagccga tgttttcccg 2766061 ctgccagccg ctccctgcac gatcaggatc ttgctttttt cattacggat aatctgattt 2766121 tgttctttct gaatcgtaga cacgatgttt ttcatttggg tatcagagtg atggcttaat 2766181 acctcttgca gcatttcatc gccaatcgtc atatcggtat taaacatcgc cttgagagtg 2766241 ccgtttttga tcataaactg gcgtttcagc accatttccc cttctatcgt ttcaccgggc 2766301 acctcgtact ccgcttttcc tggggaataa ttgtagtaca aacttgatat cggcgccctc 2766361 cagtcataga tcagaaagtg ttcctccttc tcatccaaac aggaagctaa accgatataa 2766421 attcgctctg cctgctcctc gccgttttca ataaaatcaa tccggccgaa ataaggcgat 2766481 tttttcaatt gatgaattcg tttgagctgc tgatccatgc gccgatgatt gtgttcccga 2766541 tcagacagca gctctgcctg ctgcttaatg ctagccatcg tttcaatcgc ttcatgggca 2766601 tcatcaaaat taaccttaac atcctcccaa aagctttttc ttaatccgat gatatcatgc 2766661 ttcaacccgc ccgcagacgt ttccagaaac cgctcttttt tttcgagctc cttcagcacc 2766721 tcatctattc tcgactgctc ttccttccat tccttatcct gctgattcat gaacggcacc 2766781 tccagaaaat agttgacaaa catagatgaa atactgtaaa atataattgg atacatatat 2766841 taaatatatg atgcaaactg gcaaatacaa tttataatag cacattcacc caataccaat 2766901 caaggtttgg gttatttata ttatgcagaa aaaaaccgat ttcacttcga aatcggtttt 2766961 tttgctatta attatctaag cgaaaagaac ggtttggcag cttccaatta aacatatagg 2767021 aacaaacccg gcaaacaacg agcacgaaaa acagaacgta taagccgaac gagttcccca 2767081 gccagcccaa gccgacgatt aaaccgccga gcgccgccca taccgcatag atttccgctt 2767141 tcagcacaag cggtttgcgc ccggcaagaa ggtcgcggat gatcccgccc ccgcttcccg 2767201 tcagcaccgc agccacgatc acggcactaa gcggatggcc cattttgacg gcatacagtg 2767261 cgccttggat agcaaaggca gcgaggccga tcgcatctga taaattgccc cacttattcc 2767321 aatgcttcag cagcagcttc ggaaacagaa acacaattgt aatagataaa agcgcgattt 2767381 gaaagtacgc tccctgctcc catagcgctg acaccggaac accgatcagc aaattgcgga 2767441 tcgctcctcc tccaaaagct gtgacaatcc ctaatatata aactcctaaa atatcatatt 2767501 cctcttccat cgcaacaatt gcgccgctga ctgcaaacgc aatgatgcca atcacactaa 2767561 gcagctccca agccattctg atgactccct tttatgtttg ttaaattttc tgacgacctc 2767621 tagattttat aatcgctcca gcgtaaaatc aataacattt tcatgagaaa aaaagataaa 2767681 tttagaggga atacggctat tgctgatgga catgagtttg cgaaattaaa aaagcgcccg 2767741 gcatacgcgg gcgctttttt tgttattcag atttttcgcc tttcagcagg cacataaaaa 2767801 tgataatcag gataaaagca atcagggcca ggaatggaat cgtaataaaa ccaaaccagt 2767861 taatatattg gcccgagcac ggcacgccgc tgacacatgg cttaatgccg ctaaagccgg 2767921 gcactttttg ctctaagtaa tgcatgatcg aaatgaatgc cccaataatc gccatcggga 2767981 gcacatattt tttcactcgt gtgtcccctt gaaaggtggc gatgcctaaa atcaggacga 2768041 gcggatacat gaggatacgc tggtaccagc acagttcaca tggaataaac tttctgattt 2768101 cactgaaata caggctgccc agcatagcga taagagccac aacccaggaa gcatataaaa 2768161 atacgattct atttttcata ttgttacttc cctttcagct ctttttctat tgtctctttg 2768221 atttcatcat aatccgcaaa atttttgatc actttatcat tgacgtaaat cgtcggtgtt 2768281 gcctgtatgt tcattttttg attaaggtca gaatcctttt ccacttgaga agcgaatgtt 2768341 tccttatcaa gattttcctt gagcgtctca ggttttatct ttgtggtgct ttttgcaaga 2768401 tcaccaagga ggcctggggt tacccattcc tgttccgtat ccggctgttt ttcgaacagc 2768461 ttttcatgga aatcccagaa agagtcaggg tcttccttcc atacttcttc agatgcaaga 2768521 gccgctaacc ttgaaccttt tccatggaac atgacgttca cgaaagaaaa tttcacatcg 2768581 cccttatcaa taaagtcttt ttgtattttt ggaaagatgt cactgttaaa caccttgcaa 2768641 gacggacatt tgtaatctcc gaattctact acagttaccg gtgcatcgtc cttgccaagc 2768701 acaggctgcc ctttgataga cggctgtccg gacaccgcat cattgccttg ttccgttttg 2768761 ttattaatga tgacaatggc tgctagcaat acaacaacca caaccgtaag gatgaccgcg 2768821 aatttcgcag aagactgctg tttctttttc actccgacac ctcatcgttt taaaattaaa 2768881 aaagaagcgg atcgcaattg acccacttct ttattttaac aagacaagcg ctgataagaa 2768941 aaccccgaaa aaatgaattc tctccgacaa tttatttgtt tttgagacgc atgacgcgca 2769001 tggcgttcgc cacagcaagc agtgtaacgc cgacatctga gaaaaccgct tcccacatgg 2769061 tcgcaattcc aaatgcacca agaatgagaa agatcgcttt cacacctaaa gcaaagccga 2769121 tgttttgcca cacgattcgc cgtgtccgtt tcgcaatccg aatcgcttct gctatttttg 2769181 acggctgatc tgtcatcagc acgatgtctg cggcttctac cgcggcgtct gagccaaggc 2769241 ctcccatcgc aacccctata tctgcgcgtg caagcaccgg cgtatcattg atgccgtcac 2769301 cgacaaaaat gagtttttca ctaggcaaaa gcttagcttc taatgcttcg acctgcgcga 2769361 ctttatcttg cggcagcagc tctgcatata cctcaccaat cccaagctgt tttccgacgg 2769421 cttctcccgt ttgtttcgaa tcacccgtca gcatagctgt ctgtttgatc ccaagcgact 2769481 tcagatcagc aaccgcctgt gctgcgtctt cctttatctc atccgctatg atgattgctc 2769541 cggcatagcg ttgatctaca gcaacgtgta cgattgttcc agcattttca tccgggacat 2769601 cctcaatttg ttctctttcc atgagctttt tattcccagc aaggatctca gttccattta 2769661 cctttgcaaa aatgccgtga ccggagattt cttcgtatga ctcaatctca tcggaggaaa 2769721 gcattttccc gtaagcttta cgcacagatt cagcaatcgg atgctgtgaa tgaagctcag 2769781 cgtatgccgc cgcttcaagt aatctatcct ttgtaaaacc ttccgcgggt ttgatttctg 2769841 tcacttcaaa gctgcctttt gttagtgttc ccgttttatc aaacaccgcg tatttgactt 2769901 gattcaaagc ttctaaataa ttgcttccct ttacaagcac tccggccttt gaggccgctc 2769961 cgattccacc gaagaaaccg agcggaatag agacaacaag cgcacaagga caagaaatca 2770021 ctaaaaagat aagcgcgcgg tacacccaat cggaaagcgc ggcgccagaa agaacaagcg 2770081 gcggaacaaa ggccagcaat accgcaatga tcaccacagc aggtgtataa tacttggcaa 2770141 acttcgtgat aaagttttct gtccgggctt tacggctgct cgcattctga accaagtcta 2770201 atatttttga tactgctgat tcctgatagc cctttgtgac ttcaatatgc agaacgccgt 2770261 tttgattgat aaagcctgac attacatctt gtccttccgc agcttttctc ggaacggact 2770321 cacctgttaa agcagatgta tcaaccatcg ctgacccttg cacgacctta ccgtccaggg 2770381 gtatgctttc tcccggatta accacaatga tgtctcctgt ctgaacgtcc tccgacgaaa 2770441 cctgttcgat gccgttcttt gttttgagat tggcgtaatc aggccgtatg tccattaacg 2770501 cactaattga ttttctggaa cggctgaccg cggctccttg aaaaagctca ccgatttgat 2770561 aaaacagcat aacggcgacc ccctcagggt attgctgaat cagaaaagcg ccgattgtgg 2770621 caagagccat taagaaatgc tcatcaaaca cctgaccgcg gatgatgttt ttgactgcgc 2770681 ggattataat gtcaccgccg ataatcaaat aagcaccgag gaaaaggaaa aattcaatgg 2770741 ttcccgactg aaccaaatat gccgctgcgc cgagaatgac agccgccgcc attctgatca 2770801 gcatattgac cattcgatta cgatagccat catcagctga tttctttata tgcttttggc 2770861 gaaccgttac atgcggatca attgatttca cttttttctc tactttattc gtgacccatt 2770921 gctcttcttt cccatcggct gagacagtta aggtgcttgc cgcaaaattt accgcgcatc 2770981 cgttaatgcc ttttatgcct ttgactccat tttcgatttt tcgggcacaa ttgctgcaat 2771041 ccaaaccgtc cagaacatat tcctgtttca ctagtctcac cttaccttcc gatttagggt 2771101 tccctcttca aagcgtatca atgagtattg tatttatttt atatatatga gcatatactc 2771161 atatataagt tacacctatt atatgttgtt ttccaagaaa gtgtcaatga aaaacaaaaa 2771221 ccggcatata gccggttttt cattttactt tttgcagacg aagagcattc agaacaacgg 2771281 aaacggagct gaatgccatt gctgctcctg ctatccacgg tgctaaaaat ccaagtgctg 2771341 cgattgggat gccgaggctg ttatagccaa gcgcccagaa taagttttgt ttaatgtttt 2771401 tcattgtcaa tctgctcatg cggattgcgt cggcaatgct gttcagatcg ccgcgaataa 2771461 gtgtaatgtc tgctgtttcc atggcaatgt ccgtgccagt tccaatcgcc atgccgatgt 2771521 cagctgtggc aagcgccggc gcatcgttaa ttccgtcgcc taccattgct gtctggcggc 2771581 cttctttttg caagcgggcg atttccgccg ccttttgttc aggaagaact tccgcaatga 2771641 tattcgcaat tcccgcttcc ttcgcgatgg cttctgcggt tctgcgattg tctcctgtca 2771701 tcatgatgac atcaagaccc aactctttca gacgggcaac agccttccgc gacgtatcct 2771761 taatcgtatc tgcaactgct actagccccg ctgcttctcc atcaatggat acaagcataa 2771821 ctgttttccc ttcggcctct agctcttcca tttgggcgag aagagcccca tgctcaacct 2771881 gttcgctctc cattaatttt cttgtgccga cgagaatgct ttttcctccg gcttcagcca 2771941 aaatgcctgc gccgactttt gcttcaaagc gggtaagttt cggtatctca agccctttat 2772001 ctttcacgcc agcaataatc gcttcgccaa gcggatgctc tgatcccgtt tccgctgccg 2772061 ctgcaaattg aagcaaatct ttttcttcaa aacggccgaa tggaatggca tccgtcagac 2772121 gcggcttccc gtttgtcacg gttccggttt tatcaagaac aattgtatcg agacgatgtg 2772181 ttttttctaa atgctcgccg cctttaaata aaatcccgaa ttcagcagcg cgtccagatc 2772241 cagccattat gctcgtcgga gtggcaagac cgagggcgca aggacaggca atgacaagaa 2772301 ccgcaatgaa cttgctgatc gcttcggcaa aatcgccagg agccgcccaa agataccaaa 2772361 tgagaaaagt gagaaccgca atccccaata caatgggtac aaaaatgcct gaaatctggt 2772421 cagcgagacg ctggatcggc gcttttgacc cttgtgcttc ctcaacaatt ttgatgatat 2772481 gagaaagcgc agtatccttt ccgacgttga cagctttaat tttcagaaag ccgtttgcgt 2772541 taacggttga acctgtcacg ctgtcaccag gatttttgtc aacaggaaga ctttctcctg 2772601 taatcatcga ttcgtcaacc gctgaacggc cttcaaccac ttctccgtcg acaggaattc 2772661 gttcgccagg tttgacgtaa acaatgtcat taacaagcac ttcgtcgatc gggatgattt 2772721 gctcctgtcc gtctcttaca acagtagctg ttttcgcttg aagcttcatc agctttttaa 2772781 tcgcatccga ggaacggcct tttgcttttg tttcaaacaa cttgcctaat aaaatcagcg 2772841 tcagcaaaat cgcgcttgtt tcataataaa ggccgtctgt atgcccgtga gagccaatgc 2772901 tttgaaaagt tagataaaga ctataagcgt aagcagccgt cgtaccgagg gcgaccaata 2772961 catccatatt ggcgctttta tttctaagcg ccttatacgc acccacataa aacggccagc 2773021 cgatcagaaa ctggactggt gtcgccagcg caaactgcat ccacggattg agaaatatat 2773081 ccggtaccca aatgaatgat gtaaatgtaa aatggctcac catcgcccaa agcaatggaa 2773141 atgacaggac agctgaaaaa atcagtctcg ccgtttgctt ccgttcttct ttctttttag 2773201 cagcagcctc actgtcctgt tcacccttca actttagctt atatccaagc ttatctaccg 2773261 cttctttcaa atcgctgaca gacgcttctt ttggattgta ttcgaccgta actgtttcta 2773321 aagcgaagtt tactggtgca tttgcgacgc cttctatttt gttaagccgt ttttcaatcc 2773381 gattggcgca agccgcacag gtcatgccct caatatcgaa ttcagctttt tctgtaacga 2773441 cgtgatagcc cagcttctct attttttcct gaatcgctgc agtccctgtt tcagcaggat 2773501 cgtagattac atttgatgtt tccgttgcca gattaacatt tgcatccgtg acaccgggca 2773561 tccgcttcag gcctttttca attctggcag cacatgccgc acaggtcata ccagagacct 2773621 gcatcgcgat ttccttttgt tcactcaaca tactcactcc tttatataca cctggggggt 2773681 atataaaaat gaaagaaata tcgcgcctcc ctaaaggcgc gataccttga atcacttggc 2773741 tacgtcatag ccctgatctt ctatcgcatc cgcaatatct ttgactgata ctttgtcagc 2773801 atcaaacgaa acatcgactt tacccgcttc cagattgaca tgaacggcac tgacgccgtc 2773861 cagttctcct acgcttgttt ctactgcttt gacgcagtgc tgacaagaca ttccttcaac 2773921 ttgcaatgtt ttttgttcca tatcaattcc tcctgtttat tctttctatt ttcatcctac 2773981 catacccccg tagggtatta caataaaaaa cgctttatga ttttgtgaac tttttaaata 2774041 cgtccaaaag ctcagaaatg gcctgttccc cgtctccgct tttgatggca tctgctacac 2774101 aatgatgggc atgatcctca agcaaatgaa gcgccacatt tttcattgcc gcctgaacag 2774161 ctgaaatttg cacaagaata tctacacaat atctgtcgtt ttccaccatg ttttgaatgc 2774221 ctctgacctg gccctcaatc cgcttaagcc ggtttgtaat ctgatccttt tctttcgagc 2774281 ttttatggtt taatgtttta tgttcgttat gcttttccat gcgtacacct ctgtttaatg 2774341 atattaattc ccattatact gattgtccaa acggttgtct aagcatgccg acgcaaaaaa 2774401 tgaatcagtt aggttttacc atttgatcag gagggtatat acttctgttg ataacgcttt 2774461 taaaggggag aagaaaagtg gatacgatca aggttggaat attaggatac ggattgtccg 2774521 gttctgtttt tcacgggccg ctgctggatg ttctggatga atatcaaatc agcaaaatca 2774581 tgacatcacg gacagaagaa gtgaaacggg attttccaga tgctgaggtt gtacatgagc 2774641 ttgaagaaat cacaaatgac cctgccattg agcttgtcat tgtcaccacc ccgagcggcc 2774701 ttcattacga gcatactatg gcatgcatac aggccggaaa acatgttgtg atggaaaaac 2774761 caatgacagc aacggccgaa gagggggaaa cattaaaaag ggctgccgat gaaaaaggcg 2774821 tattattaag cgtatatcat aaccgacgct gggataacga ttttttaacg attaaaaagc 2774881 tgatctctga gggatccctt gaagatatca atacatatca agtttcctat aaccgctaca 2774941 gacctgaagt tcaagcgcgg tggcgggaaa aagaaggcac tgccactggt acgctgtatg 2775001 atctcggctc ccacatcata gaccaaaccc tgcatttgtt tgggatgcct aaagccgtga 2775061 ctgcaaacgt gatggcccag cgggaaaatg ccgaaacggt tgactatttt catttaaccc 2775121 tggattatgg caagcttcaa gccattctat acggaggatc aatcgttccg gcaaacggac 2775181 ctcgttatca aatccatgga aaagattcta gctttatcaa atatggaatt gacggacagg 2775241 aagacgcact cagagcggga agaaaaccag aggatgacag ctggggtgcg gatgttccgg 2775301 agttttacgg aaagcttaca accattcgtg gctccgacaa aaaaacagaa acgattccat 2775361 cagtaaatgg ctcctacctt acttattacc gtaaaatagc ggaaagcata cgagaaggtg 2775421 ctgcgctgcc agtcactgct gaggaaggta ttaatgtcat ccgcatcatt gaagccgcga 2775481 tggaaagcag taaagagaaa cgaaccatta tgctggagca ctaaaacaaa agcctcccca 2775541 aataagggga ggctttttca ttagaatgtt tttcctgctt ctttcgcacg cgcaatcgcg 2775601 tcttctttga tttgctgtgc tttatcaggc tccgcattat gtccctctac gaaaatgcca 2775661 tcgaatgatg gtacgccgaa gaagttcatc atgatgccga tgtagcggtg ccccatttcc 2775721 atctcagccg cagggccttc tgaatagtag ccgccgcgcg cttggatatg aattgctttt 2775781 ttatcagtta acaagccgac aggaccttgt tctgtgtatt tgaatgattt tcctgcaaca 2775841 gcaacagaat cgagatacgc tttcatcact ggcgggaatg agaagttcca taaaggagta 2775901 acaaatacgt acttatcagc tgatgcaaat tgatcgctaa gctctcccaa acggcctact 2775961 ttcgcttttt cgctttcaga aagctcttca aagcctgtac ctgactgaag ctttccccat 2776021 ccgctaaata catctgcgtc aatgtgcgga atgttttctt tgtacaaatc gatatgtaca 2776081 acttcatcat ttggattcgc ttctttgtaa gattcgataa atgctttacc tgttgccata 2776141 ctgtacgaag ttgcttcgtc atgtggatga gcagtgatat ataatacttt tgccattttt 2776201 accagccctt tcgtttttaa aaatcacaca tcaattatta tcatacagat gcataatgat 2776261 tattctgtct ctcttagact ttattataga gacaaagaaa tttactttca agtaaaacat 2776321 ctcgaattaa agattattta actttcccaa acagcttact tttcaaaagc tgttctcaag 2776381 ccggaataca gcgcggacaa ttctttactg atccgaggat aatgagggac atgcggcact 2776441 tgaatatccg caggcatcct tttcatgata aaggattgct cagcctgttc aaaaaacgcc 2776501 cgcagctggt tgatctcttc atcagaaaac ggagcagacg gacggcggtg agcttgcgcc 2776561 gagagcaaat agtaccctaa gtgctgagca ccggaaatgg caggccagag cgcatccgca 2776621 ttcgcgtgag gaaactcgcc aagcgccttg tcatacgcat cccgaagcct gacaagactc 2776681 acccttaact tgtgttcgtc ggcaatttgc ccggttaaca gtttctccat aaactgccct 2776741 tccagccgga tgacattccg cacaagttct ggcagccgct tggttgaaaa ccgccgccac 2776801 aaaagcattg ttcccaacag cccgatcacg ctgccgacag ctacatcagt cagcctcgct 2776861 atcataaaat aaccggcgcc cgccccgcca tgcatacttt ctgtgataac aagcgcattt 2776921 gcggttaaaa agggaacagc cagcgcataa ttgcggacga tcagcatctc aagaagacat 2776981 tgcagcgctg caatacaaaa cgcaatataa acaccgcccg gcttaaaaaa caggattgcg 2777041 cctgccagta taacaccgat caccgttccg gccgaacgct gaatagccct gtgaagcgta 2777101 aaaacaacag tagtgccaag catgaccgct gctgccgaaa gcggaatcca ataggagcgt 2777161 gcaaagccga atgcgagggc aaacatatcg gcggcaaaca gaacaattcc gtactttaac 2777221 gctctaatca aaactggaga cttccagtca aaggcatttc tcaaaaagta aaaagaggat 2777281 ggcaggcggc ttggttcccc gtcaagctgc ttatcaaaac gtcctgaagc gatatacaaa 2777341 acctcattga tttcttcaaa cagcttccgc ctaggctcag attcattttc attaatctga 2777401 aacgtattga aaacccgtgc attcgcaagc atatctccgg tttggcgaag tgccttttca 2777461 atctgcgcgg tctctctgtc cggcgtttca gctgaaaaat gaataatggc aataaatatg 2777521 tcgtcagctt tctcaaggag gcgaaaaaat cgttcatcat gccgcgattt tttccgtctg 2777581 ttccctttcc caagaaccgt ttggcgggct gttctaagca tgagcaccgt ctgatgctgt 2777641 gcgttatgaa aacctggcgt tccgacggct gaaagacatg cagccagctg atgatatgtt 2777701 ttttgcagca ccgctccctc cggtccatgt ttgttccata accagccgat taaagcgata 2777761 cccatggcga aaatgccgcc gagaaacgtc agtcccgctc tgaacagcgc ttgtgaagga 2777821 tcggccggca gcccggaact gactaaaaag gcaaggacaa aaaacatcgg cgcagggcct 2777881 tgaatgccga gcgcgctaaa aataaacatc gccgctgcac cgatcagccc caaaacagcc 2777941 gccatcatcc aaagcatccc ggacaaaagc gtccctaaac caaatgagag ggcgatccca 2778001 atagaaacca agagcagctt caaggcgcgc tttttgtacg attcaccgcc cgcatataaa 2778061 taaacaaagc ctccgatact tgcaattaat ccgtaatccg tgtgacctgc caatgcaccg 2778121 accagcacag gaaaccctga agcgaaacct gatccgatag cctttttcca aggaaatgga 2778181 tttgcatgaa tgcgaaaggc atccttcacg ataggcatga ttctttgatt gttcgcagca 2778241 gttttgttca tttgacaaaa tccttttcaa tgaatgtgta gaacttttcc agtttcttcg 2778301 ctttagtatg cccaaaaacg cggttagctt ctcaattggt gcgcacgata aaaaaacaga 2778361 gacttatacc gtctctgctt cattacatca gtttattata aaagcggcac ctgtcaggac 2778421 tgttttgtcc ttctgccttc cttcaagagc aggtgaataa aaaataaagg ataaatcaat 2778481 agatacccat taaacagcca ccacacaaga tcaaagtcac tgctgaatgt ccagaatgat 2778541 agcgcctgca gacctgaaca acaggtcagc acaagagaaa tcagcgccat cagcttccag 2778601 tcagcacgat tcacccgctg taggtacaag ctgtacaacc ctgtgacaga aatcaggata 2778661 tccagcggaa aaaaagacca gttccaagcg atcataaacg gatggtcatg atgtttaaaa 2778721 gcccagcttt ccggtatgag cgaaaatccg gctgacagcc agtacaagat aaaaccgata 2778781 tcagtcacga gaaaaaacag cttcatatat ctcatttgta ctgcccgctt ttatgtaccg 2778841 gctcagacac cgcaacatgc tcgatcaggt ttaaagacac aacaccggca ataatcaatc 2778901 caattgaaat gactttcatg acactcacat gttcttgaaa aaacaaaaaa ccaacgactg 2778961 taatcaagac aattcccatc cctgaccata cagcataagc aactgataca tcaatggatt 2779021 taagcgtaag cgtcagaaag aaaagactcc ctccataaaa gaaaatcaac agcaaactgg 2779081 gaataagctt tgtaaaacca gacgatagct tcatgctgac agttcccgca acctcaaaca 2779141 aaatcgccaa gcatagaaac acccaattca tgtggcatca gcctcctcat cagctgttat 2779201 accgttaaac aaaacatcta caattgattc aagtacctct cctgtcgtga actgatgttt 2779261 cagcggatat tcagggtcat acacttgatt gatgctccct atatacatgt gaacaaacag 2779321 gtccggattg atgtttctga ttctcttttg ctgtttgcac tcatttaata atgctaggac 2779381 aatcgcccat tcttccttaa taaacgcgtc taatgtaagc cacgcatcgt aatggtattt 2779441 ctttagttca tttaataatc ccatgttcag cagttccatc ccctgcggaa ggctgatcag 2779501 catttgtttc accttttcga gcacatttaa actttcattt tcatagatgt ctctttctat 2779561 ttgcttcatt tcagctataa attgttcgac aaccgcctca acaagctgat ctttagatga 2779621 ataatatgca tagagcgtcc gcttgctcgt tcccagcgct gccgccaaat cattcatcgt 2779681 aaatgaaaat cctttctgct tgatcagccg gaaggtttcc gccagaattc ttttatccat 2779741 attaatcccc cgctttcggt accaagaaaa ctatttcggt accaatatta tacggcagaa 2779801 atttatggaa atcaacaata tataaaaaaa cctctcctat tgggagaggt ttaaaagaca 2779861 ctgcggacca aaccgccgtc cgcccgaagt gccgcgccat tgatcgcaga ggaaagcgga 2779921 ctgcttaaaa atgtaacgaa gtgggcgatt tcttccggac ggatcagtct ttgaataata 2779981 gatgtcggcc ggttttcttt cataaaacgt gcctcagctt cttgaacagt caggttttca 2780041 ccaggataca gcgagttcag catggtttcc acaccctctg ttaaggtaga gcccggcatg 2780101 acggtgttga ctgtgacatt cgtgccggtt gccagctccg ccaaactgcg ggaaatggac 2780161 agctgcatcg tttttgtcgc actgtaatgg gccatttcct gtgacggcat aatcgccgct 2780221 tcactggcaa tgaaaatcac acgcccttct tttttctcta tcatgttatg caaatacctg 2780281 cgtgtcagcc ttacaccgct cataatattc acttcaaaaa aacgaaacca ttcatcgtcg 2780341 ggaatatcaa agtactccgc cggttcaaaa atccctaaat tgttgaccaa aatatcaacc 2780401 tctggatatg cctgaaacag ctcattgcag ccttcttctg ttcccaaatc aaatgcagcc 2780461 ggataaagaa ccgcttcagc atgttgtgtt ttcagttcat ctatcgtttg attcactttc 2780521 tcttcccggc gtccgttaat gatcactgcc gcaccttctt cagctaacga agaggcaata 2780581 gcttttccga tccctgatgt cgaaccggtc accagtgcgg tttttccttg taaattcagc 2780641 ttcattattc atccctccgt ttttgattcc tcttatttat tgacagaaat ctgattggtg 2780701 aaacatctgc tctgcaatca gtatgaaaca gctgggattg aaatggaagt acgcactttt 2780761 tggtgcctgt ggtttggaga aaaaataaag cagaacctct taagaggttc tgctttattg 2780821 tcagtatgta tggagacggt gggagtcgaa cccacgtcca gaaacatcga ttacttaagc 2780881 gtctacgagc gtagcctgca tatttatggt ttcactcatc ttcttgcctg cgggcgggcc 2780941 ttccgagagc tagtctgttc atctcttctt acgttctcag acgggaacgc aagcgtagcc 2781001 tacttggatg tgctcttcac agacacatag gcaatgtcag gaagagctcg ctgcgcttat 2781061 taggcagcta atgctacgtt ttggttaaaa ctgttagttt tgccagttat atttaagtgc 2781121 gtgtttacga gatcgcctct cggctcgcag ctcaagctcg atccatccct gtcgaatccg 2781181 taacgtcccc ttggtataag ggaaatacgg gagaaaatat caagctctca ctcaaactgg 2781241 ctatagtctt attataacat gatcacggct cttttcaatt gtcaaatcct tcaaatgaat 2781301 ggcgtcgtga tctgatcgtg aacacagtat agcacaggcc tgattttcga atcaagcact 2781361 atgcctttag aagccttttt gactgtctct gaacgctctt tcgatttccc gcttcgcgtc 2781421 cttgcgcttc agatcttccc gtttgtcata gttcttcttc ccttttccaa ggccgagaag 2781481 cactttggca aagccgtttt ttaaatacag cttcagcgga acgagagaat agcctttttc 2781541 ctttgttaac ccgatcagct tattaatctc cttgcggtgc attaacagct ttcttgtccg 2781601 gagcggatcg tggttatagc ggtttccctg ctcatatggg ctgacgtgca tattgtggag 2781661 aaacacttct ccccgttcga ttttggcgaa ggaatcctta aggtttacgc ggccggcgcg 2781721 aatcgatttg atttcggttc cttgcagaac gatgcctgtt tcataggttt cttctataaa 2781781 ataatcgtgg ttggctttct tattttgaga taatactttt cctgaccctt ttggcatgcc 2781841 agaacctcct ctctctaagg aaaaactgtc caccttttgc gatacgctct attttaccaa 2781901 atgtcacgta ccgctacaat gaaaagctgt ttccgaaaga aagcaaatag agcgctgcgg 2781961 ccctatttgc tggttgagct gctatttctt ctttttccgt ttctgtttcg gagcattctg 2782021 gaagccgcgt tttttctttt tcttcttcgg cttagtgaac cactcccctt tttcctcaga 2782081 cggagctgga gaaacaggtg tattggtgct ttgaacacgt tttctggcag gctttccgcg 2782141 ttttctgctc cggctgctgt ccaattctct cggacgccgc ggagtgcctt tcatgccgac 2782201 aatttcaaag tcgatattgc gctcatcttt attgacatcg acaaccttga ctgtgatttc 2782261 atccccgatg cggaagacgt tgcctgtccg ctcgccaatc attgcgaaat gctgttcgtc 2782321 aaagcggtag tagtcatctg tcataaagct gacatggacg agtccttcaa ttgtattcgg 2782381 cagctcgacg aacattccga agtttgtcac agagctgatc atgccgtcaa actcttcacc 2782441 gattttatca agcatgtatt ccgctttttt cagatcatcc gtctcacgct cggcgtcaac 2782501 tgcacggcgc tccatagatg atgtatgttc ggcgatatcc ggcaggcgtt cagcccactt 2782561 ttcctgtgtc gcttcatcga ccttgccgtt gatcaaatac gttcggatca gacggtgaac 2782621 gattaagtcc gggtaacggc ggatcggtga tgtgaaatgc gtatagaatt ccgttgacag 2782681 accgaagtgc cccaagcttt gcgggtcgta tttcgcctgt ttcatcgaac ggagcataac 2782741 agtagatata accgtttcct ctggtctgtc acgcacagcg tccagaatgc tttgcagcgc 2782801 gcgcggatga atattccccg ccgttccttt caccacatag ccaaatgtcg tcacaaattc 2782861 taaaaacttt tgcagctttt cagcattcgg ctcttcgtga atccggtata taaacgggac 2782921 attcatccaa tggaaatgct ccgcaactgt ttcgtttgct acaagcataa attcttcaat 2782981 cagcttctcg gcgacagagc gttctctgat cacaacgtct ttaaccgctc cttcgtcatc 2783041 aacaagcacc tttgcttctt tgaaatcaaa gtcaacggcg ccgcggtcca tccgcttatc 2783101 gcgcagaatt tgagccagac gctccatgtc tttgaacatc ggaacaagag gctcgtattt 2783161 ttgtttcagc tcttcatcat catcaacaag aattttattc acatctgaat atgtcattct 2783221 ttccgttgtt ttgatgacac tttggaagat ctcgtgctct gtcacctgtc cctgactgtt 2783281 aattgtcatt tcacaagaaa gcgtcaggcg gtcaaccttt ggatttaagg agcagatgcc 2783341 gtttgacaat ctgtgcggaa tcatcgggat gacacggtca accagataca cacttgtccc 2783401 tctttcaagc gcttctttgt caatcggcga gttttcggtt acgtaatggc tgacatcagc 2783461 tatgtgaacg ccaagcttgt agcttccatc atcaagcttc gtcacggtaa ctgcatcatc 2783521 caaatccttc gcatccgcac catcaatggt gacaatcacc tggtcacgga gatcacggcg 2783581 gtctttcaga tctttttcat caatcgtgtc aggcgtactt gatgcctgtt ccatcgcgtc 2783641 agctggaaat tctcccggca ggccgtgctt atgaatgacc gataaaatat caatgcccgg 2783701 gtcgtttttg tggccgagaa tggtttcaac ctcaccctct gcgttcatgc ggccttcagg 2783761 atagctcgtc agcttgacaa caaccttatg cccttccgca gctccatttt tcccattttt 2783821 cggaatgaag atgtcactcg tgattttttt gtcgtccgga atgacaaagc cgaagtttct 2783881 cgtttctgta tacgtgccga caacccgctg aatcgctctt tctaaaatcc gtatgacggt 2783941 tccttcctgc ctggagccgc ttgattgtga gttcagacgc accatgacga tatcgccgtt 2784001 cattgccgta tttagctcat taggcggaat aaacacatca cttaacgacg tatcctcagg 2784061 cagcaaaaag gcgaatcctt tcgcatgggc tgaaatcttt ccttttatta aattcatctt 2784121 ctccggaatg ccgtagcggt cgcttctcgt ccgtacgata agcccttttt cttccaaggc 2784181 gactaacgct ttgacgagct ctttaaactc ctcggcttcc gtaatattta acatctcctc 2784241 aagttcctga acggtcagag gtttgtacgc ctcttccttc ataaacgaga gaagcttttc 2784301 cataaatgct tctttttcca ttatccgacc tcctgttgat taccaatcga gcttctctaa 2784361 aaattcatac acatcctgat ggacgaggtc acgttctttg tcgagtgtaa tgacatgccc 2784421 tgattcctcg taccatttca gctgtttatc atcagtttcc acttcgttgt aaataatatt 2784481 ggcgctttcg gtattaatca tgtggtcatg acgggcctgc accacaaatg tcggtgaata 2784541 aatcatatcg acattattcc gcacatcagc aattaagtct tgcagcgcct tgagggtatt 2784601 catcggcgtt ttttcgaatt ctttcatttc ctcttcaatt tgctccgggc ttttcccctc 2784661 aaactttttg taattgcgag cgtatgaaag aacgccttga tacatgacct cttcactctt 2784721 aatatgcatc ggtgcgcaca ttgggacaat tccctttatg ggtacagtgt aacccaattt 2784781 cagcgaaaaa accccgccaa gcgacagtcc gcaggcagca atgctctcat aaccttcaga 2784841 ttttaaatat tcatagccat ccattacgtt tttccaccag tcttcgggcc ccgtatgtac 2784901 aagttcttca ggcgggacgc catgtccttc atattgaggc gcgtggcacg tatagccgcg 2784961 ttcattcaaa tatcgtccca gcatccttac atccgctgta tttcctgtaa agccatgcag 2785021 caaaagcacc gctttgtctc cgcctttaaa tgtaaatggt tttggtgtca caactttcat 2785081 gctcatgtct ccctttctat ctgcacgatc attttagttt tccacagttt aatcagaaaa 2785141 aaacgttttg aatatcatcc agaaacgtga aaaaggcctg acttcacatc agaccttata 2785201 caaacattgc cctataggat ataagcaagc gcaatcgtta acacgaaaaa caagactgcc 2785261 agcactaccg taatgcggtg caaaattaaa tcaagacctc ttgctttttg tttcccgaag 2785321 agctgctccg ctccgcctga aatcgcacca gataatccgg cacttttact ggattgaagc 2785381 aaaacgacaa taataagtgc aatgctgacg ataaccaata aggtaatcaa aactgcgtgc 2785441 atcccataca cctccagact cactggctac attacttcta ttttacatga aaagggttgg 2785501 catgtcacgc tgtatcagac gccaaaaggc cggataagac gttttatctt ggttacccta 2785561 ttcatatgaa aaggtcaaag gagaaaagcg atgccgctta tcagcataga cagcaggaaa 2785621 catctttttt atgaagaata tggacaggga atccctatca tttttatcca cccgccgggc 2785681 atgggacgaa aggtttttta ttatcagcgc cttctatcca agcatttcag ggtgattttt 2785741 ccggatttaa gtggccacgg tgatagtgat cacatcgatc agccagcgtc tatttcctat 2785801 tacgcaaacg agatcgcgca attcatggac gctttgcaca ttgataaagc tgtgttattc 2785861 gggtattctg ccggaggctt aatcgcgcag catatcggct tcacccgccc ggacaaagtg 2785921 tcacacctta ttctgtccgg cgcctacccc gctgttcata acgtaatcgg ccagaagctg 2785981 cacaaactgg gaatgtatct gcttgaaaaa aaccccggtt tgctcatgaa aatcctcgct 2786041 ggcagccaca caaaagacag acagcttcgc agcatattaa cagaccatat gaaaaaagca 2786101 gaccaggccc attggcatca gtattatctg gattcgcttg gctacaactg cattgaacag 2786161 ctgccccgcc tagaaatgcc aatgctgttt atgtatggcg gcctgcggga ctggaccttt 2786221 acaaacgcag gctattaccg aagatcgtgc agacatgccg aatttttcag attggaatat 2786281 cagggacatc aattgccgac aaaacaatgg aaaacgtgca atgagctggt gacagggttt 2786341 gtgctgacac atcattcata ggaatagaaa acgcttggct tccttgcgtt ttttgttact 2786401 ttattgactt ttgtcaacga aatcatagta aaaaagatcc tcaaatttca aattaaaata 2786461 gtgaagcatt ttaccaatca caagctgccc cggccttctt tctccattca gcacgcggct 2786521 cagtgtggcg ggtgagactc cgatttccag cgcaagctga ttaagggaat aatcgttatt 2786581 aaccatatac tgcaagacat aatcacgtct aatctgtatc ttttctactg gcactttcct 2786641 caccttccat tcctgaaaaa cttttttcta tacttttaca ttacggctta tgttaacttt 2786701 tgtcaataca tttccagtct acctattccc tttagtcaat aaacatacta aaatatgagt 2786761 aacagtgagg gacggggtga gatatatgga aagctttggc gaacaattac gggcattgcg 2786821 tgaagagaga aagttaacag tcaaccagct ggcgacttat tcaggcgtaa gcgcggccgg 2786881 catctccaga atcgaaaacg gaaaacgggg cgttcccaaa cctgccacca tcaaaaaact 2786941 ggcagaggcc ttaaaaattc cttatgaggg gcttatgtac aaggctggtt acatcgaaga 2787001 agtgcatgaa gccagggccc cttatgaaac gaagtgcaag ctgcttgaaa aagcggaggc 2787061 ctatgacctg aaaaaccttg cgcttcttga gaacgaaaag tggcaatatc tcaataaaga 2787121 agatttgctc atgctggatc attatttttc gtttatttca gatgaagcga aaaaacggtc 2787181 tgctgatgac tgactcttga tagaaatgtg aggcgataga ccatgtcacc gttcggacag 2787241 caattacggg agctgcgccg cgcccgcaaa ctgacagtga atcagcttgc ggtgtactca 2787301 ggcatcagct cggccaccat ttcaaaaatt gaaaacggca aacgcgggac gccaaaaccc 2787361 gccacgatta aaaaactggc agccgtcctg aaagtgccgt acgaaaacct aatggccgcc 2787421 gcaggccata ttcaggcctt tcctgaagaa atccgcgaag catctgaagg ctatcaatcc 2787481 gtttatgaaa tttaccagac ggctgtcaca cgcggagcgg agcacctccc gattttcaat 2787541 agtcaaaaat gggaacatct ctcaaagcag gatattgaaa atctcagcaa atacttcgat 2787601 tttttgtctt cagaagcaaa aaaacgcgcc tcttcctcat aatcccctgt ttctctttct 2787661 atattttatc aatcacgctt gcatgccctc cctcgttatt tgcgttataa tagtgacaga 2787721 cgaggtgaaa agtatgaacc aatcagaaat gtgtcctaga tttgaaaaag cagtcgacat 2787781 cttaagtaaa cgctgggtcg ctttaatcgt atttcagctc ttgaacgggt cgcagcgatt 2787841 tagcgaaatt gaagcagcac ttccaaatct aagcggcaga gttctgtcag aacggctgaa 2787901 agaacttgag cttgaaggag tagtgaagcg ggatgtcatc cctgaaactc cggttcgcat 2787961 cgaatattca ttgactgata aaggaaaggc actagcaccc atattaggtg agatttctaa 2788021 atgggcgact gaatggattg acccttcctt tcttgactaa ttgctaaaat ggttctgatc 2788081 tcaaagacga gaaaagaacc gttttttatt ttccaggtga aaaaaagata tctcagccga 2788141 tatatagtac atccacacat tacgttttta aaggagacca ctatatgcga ctgacgattt 2788201 cccgcaaatt cagcctggta tttttgacac tgatcctgat caatttactt gtaggcggaa 2788261 taggcgttct taatatgcag catatcattc aaaaaacaga tgaaatcaac acaaaatgga 2788321 ttgacggcat caaaggaatc acttcaatta attatgtaac cgagcacctg tcttctaaag 2788381 aaaaggactt tctgatttat acagacaaaa gtaaaatgga tacacttgat caagaaatga 2788441 atcaaatcat ggaagacatt aaccaaaagc tcgataacta cgaaaaaacg atctccactg 2788501 ataaagagca gaaactgttc gagcagcttc aaactaaagt gaatacctat atggatattc 2788561 atgcgcaaat tatcgaaagc ggccgcacga atgacatgga caaagcaaga ggtttattgg 2788621 ttcagactga ggccagcttt gaggatatga aaaaaacaat cactcagctt gttgacttaa 2788681 atcaagaagg cagcaacaca gcggtaaaag aaacgaaggc cgtctatcat aaagggctca 2788741 tttacactgc tttgcttgtg gcagcatcaa tcctcatcag cattttcatc tggctttata 2788801 tcacgcgaaa cattgtaaag cctatcattc gcatgaagga atctgccaat catattgccg 2788861 aaggcgattt gtcgaacgat atggaggccc tcaactcaaa agacgagctg ggtgatctga 2788921 atgaagcgct gcaaaaaatg gtagggaatc tgagagatat tgtcggatat tctaaagaca 2788981 tatcaagccg ggttctttct tcttcacagg tgcttgcaac cgcaacgaat gaaacaagat 2789041 ccggcagcaa acatattacc gagacgatga acgaaatggc tgagggctct gaacagcagg 2789101 cccaagacgc ggtgacgatt gccgaatcga tgaatgagtt taccgaaagc attgataaag 2789161 cctataatca cggcatcaca atcagcgata cgtctcaaaa cgttctcgaa ctcgcggtaa 2789221 gcgggaacga aaatatggct acgtcattac agcaaatgaa aaccatccat catattgttg 2789281 aagaagccgt gcataaagtg agatcactgg aacagcattc tcaggatatt aacaagctcg 2789341 ttcaggtcat caacgggatt gccgagcaga cgaatttgct gtcccttaac gccgcgattg 2789401 aagctgcccg cgctggagaa agcggcaaag gcttcgccgt tgtggcagag gaggtcagaa 2789461 agctggctga cggcgtttct gattccgtgc aggacattac ccggattgta aacgggacac 2789521 agcaggagat ccacactgtc attacgtact tggaaagcag ctttacagaa gtcgaaaaag 2789581 gaacggaaaa cctgacagac accggacagg ctatgcagca tatcaaacaa tccgtcaccc 2789641 atgttgcaga cagcattaag gaagtaacgg atggcttgaa gcagttaaca aaccaatcga 2789701 ttaccatcaa tcaatcgatt gaaaatatcg cttctgtatc cgaagagtct gccgccggca 2789761 ttgaagaaac attttcaatt accgagcaat ccgcccattc gatggatcaa gtgcttctaa 2789821 atgctgaaga gcttgagcag ctggccaatg agcttaatga gaagatgggt cagtttacga 2789881 tttaaagaga aaaaagaggc tggactccag cctctttttc tattctatgc agctgattga 2789941 acatgtttcg ccccggttct ttttttcttc accggactta atgcccgctc cagccaagcc 2790001 atgagcaaat ccgcccctac cgccatcacc gcagttggta tcgctccggc tagaataatc 2790061 gcagttccgt ttgttgcgtt tgagccgcgt acgatcatgt ccccaaggcc tccggcaccg 2790121 acaaatgtgc cgatcgctgt aattccgatg gcaatgacga gagccgtgcg aaggcccgcc 2790181 ataatgacag aaagtgcgag cgggagctca accattctga gcacttggaa tttcgtcatg 2790241 cccattgctt ttccagattc taagtaggca tgttcaatac tgataatgcc tgtgtacgtg 2790301 tttcgaataa tcggcagcag ggaatacaga aataatgata gaatcacggt atttgcgccg 2790361 agccccataa caagcattaa gacggccagc atagcgagcg ccgggattgt ttgaataacg 2790421 tttgttacgg caaacaccca ggctgacaaa cggcgaaaat gcgcgatgag gattccggcc 2790481 ggaaccccga cgacagcggc aaataaaacg ccgtaagccg acatgagaaa gtggcggccg 2790541 aattcatcca tgacgtaact gccattctgc gcgtaatacg tcattaactg ttcaagcacg 2790601 ttcattgacc tcttccccct ttcacgattc gaaatagcga tgtttttcta aatattcctt 2790661 ggcaacgaca gacggttctt tgagattgcc gtcgacttca tagttaagct cctgcatcgt 2790721 ggctgtgtcg atttttccga gcattttctt gatgatgcct tcaagttcag gatgttcttt 2790781 gagcaccttt tccggaacaa ccggagagca gtcgtacggc gggaaaaatt gtttatcatc 2790841 ctttagcatt ttgagaccat aggacttgat tcttccatcg gttgaatacg caagcacaat 2790901 gtccattttt ccgcttttca ccgcgtcgta cacaaggccg atctgcatcg gatacgtgcc 2790961 gccgaatgtc atgccgtagg ttttcgtaaa atcctgatag ccgtttcctt tgagcttcat 2791021 ccaatagtta tcaacgccca gctttaattg cggcgcccat tttttaacgt ctgatacggt 2791081 ctctaaatgg tattggtcgg ccagctcctt gctgactgta aaggcatatg tattatcaaa 2791141 cccgtaggag tcataccact ttaaatcata tcttttttta aactcccgct gagtaagcgc 2791201 cagcgctttg tccggatctt tttcaggttc cattctcaac gtgcctgtca gcgcgtctcc 2791261 cgtatatctt gtggccgcaa tgtcgatttc cccgttcatt aaagcctgct gctgcaccgc 2791321 gttggagcca agatttttaa tcgttgttgt tttgagatca gtatggtgtt cgatcaactg 2791381 gccaagcatg ctggcgatga tttctgattc gctcatgctt tgcgcgccga ttttaatggt 2791441 ctggtctgca gcagcgctga gaccaggaag cgaacagccg ctcagcgtca gcgttgccgc 2791501 aagtgctaaa cctatcatta atttgagata ttttcttttc atgagccgcc tccttatgac 2791561 aattccttca atctctgcat gccggcaggt gtcagttttc gttcagcaac tgccagcaca 2791621 taatcaatca caattgccaa tatcgtgaca ggtaccgcgc ccccgatgat atattccggc 2791681 tgatataaat tcagtccgat aaaaatgtaa tcacccaatc cgccgcctcc gataaaggaa 2791741 gcaagcgtgg cccagccgat taagtaaatc gtcgatgttc tgattcccgc catgatcact 2791801 ggtgcggcaa gcggcagctc caccaagcgg acttgttcag ccggcgtcat tcctattcct 2791861 ttaccagact cgagcagatt tttgttgacg ccgcgaatgc cggtatacgt gttgcgaaga 2791921 atcggcaata cggaatagaa aaacaaagcc acaatggccg gaaccttccc tacaccaagg 2791981 agcgggataa aaaaagcgag gatggccaga ctcggcagcg tctgaatgat attgacaatg 2792041 ccgataatgg tgccggctcc ttttttcatt ctggtaagca caaccccgag ggggacggca 2792101 accagcacac ctaagatcac agcaatgagc gatatcgtaa tatgctcgta tgttttataa 2792161 agaagctctc ccccattggt ttgcaaaaat tgaacaatat gatgcatgac ttatcgcccc 2792221 tccctatgac aatgctgcga gctgcttttc ttctccccag agggagtcat acacgatgtc 2792281 gaccagactt gccctcgtca caattccgat caggcgtcgg tcttcatcca caacgggaac 2792341 atatttgaca ccccgtttta aaattttgcg gaccgtgtcg cgcagcagtg tgccgcccag 2792401 tactgtgtat atatcttcat gtaaaacttc actgacgaga ttggcctttt tccggcattg 2792461 atcaatgatt tcaacatcga catagccttg cagaacgcgc tcgtcattga cgaccagcaa 2792521 tgaatcgacc cgttcctgcc tcatcagctg aatggcctca gaaagcgttt tatccgcggt 2792581 gatcgttaca ggctgtgtgt tcataatctg gtcaacccgt tcaacatccg ggctggatga 2792641 ctgaatcagc cgctccttgc cgataaattc ctcaacaaat tcgtctgccg gatttcttaa 2792701 aatgtcatcg ggcgttccaa cttgaacgat ttctcccgct tttaaaatca caatccggtc 2792761 tgccagctta atcgcttcat ccatatcgtg ggtaacaaat acgatggttt tatgtaaggt 2792821 tttttgcagt tttttaaatt cttcctggag ggaatccctc gtaatcgggt cgagtgcccc 2792881 aaacggttca tccattaaga taagcggcgg ctccgcggca agtgcccgta atacaccaat 2792941 tcgctgctgc tgccccccgc ttaattcatg agggtaacgg tctacatatt ctggccccat 2793001 atcgaccaat tttaaaagct cacgcgcccg ctctttccgc tgctgctccg gccatttcag 2793061 cagttttggg acgagtgaga tattctgctg aatggtcata tggggaaaca ggccgatctg 2793121 ctgaatcaca tagccaattt tgcgcctgag ctctacagga tcctggtcca tgatgttttc 2793181 gccgtcaatg aaaatcttcc cggcggaagg ctcaattaat cggttaatca ttttcattgt 2793241 tgtcgttttt ccgcagccgc tcggcccgat aaagcagata aattcgcctt ttgcaatctt 2793301 aagatttacg ttgttcacgg cttttttgcc gcccttgtat gttttcgaga cattttctaa 2793361 tgtcagcaaa catcgcacct ccaaaattaa gtttattcaa tttgttcagt ttaaatttaa 2793421 tttttcagac aattgaatgc ttcccattat agaataaagt ttataaaata aaaagtttac 2793481 aatttgttca tattatttat aaagtatgtg taaacgctga tttacccgca ttgacgtgtg 2793541 ttgatctcct tattgctcca atttcctgcc aaattctctt ttgacagcat tttcgccgta 2793601 tcaaaaatgt ggtatattga catcggaatt gttagctgaa aggatgaaac cgttggagaa 2793661 agatccgtta acgatcattg aacaagccga ggaccatttt atagaaagaa tcgcggaaaa 2793721 catgcatgca tttggaatgc cctctaccgt cggacgagtg ctgggcatta tttatatgaa 2793781 tcgaaaaccg atgacgctta cggaattatc tgaggccacc ggcatgagta aaacacgtat 2793841 gagccaggta gtgcgggaaa tgcttgatgc caacattgcc gagaaggtat tcgaaaaagg 2793901 cgtgcgaaaa gatttatatg aggttgagca ggactactat caaacattta tcacgctgtt 2793961 ttcagccacc tggagcaaag tcgtcagcaa aaacaaaatg atgcataaaa aactcaatcg 2794021 ggagctgctt agcgtgttgg atgaagagct tactcctgaa gcggaagaaa aagtgaatga 2794081 gctgctgaag gaattaaagg aatggctcga ttattataat tggctcagcc gtttgattga 2794141 gttttttgag agcgaagaca tttttaaata tgtgccgaag ccgtaaaaag ttcccaaatt 2794201 caattctggg aactttttta agtccaatcc aaatggttga atatcaaact tcgagctccc 2794261 aacgctggaa aatatgttta acagatacta acacatgttg tttatttaaa aaaaccacct 2794321 ctgttgtatt taaatagagg tggtttttct atcagctata ataaaatttc cttttttctt 2794381 tttaatcggg cttaatgctc gttcaagcca gcccatgacc aaatcggcaa tcaccgccat 2794441 cagagctgtg gggatcgctc ccgctaatat aatcgcggtt ccgtttgtgg cgtttgatcc 2794501 tctgacgatg atgtccccga gaccgccagc accgacaaat gtcccgatgg ccgtaatgcc 2794561 gatcgcaatg acaagcgcgg tgcgcaggcc ggccattatg acagaaagcg caagcggaag 2794621 ctcgaccatc cgcagcactt gaaattttgt catccccatt gcttttcccg attcaagata 2794681 ggcgtgctca atactgataa tccctgtata cgtatttctg ataatcggca gaagagaata 2794741 cagaaataat gacaatatca ccgtattagc gcccagcccc atgacaagca tcagcacggc 2794801 gagcatggcg agagccggga tggtctgaat gacattcgtg accgcaaaaa cccatccgct 2794861 taatcttctg tatctggcta tcaggatgcc gagcggaatt ccaacaatgg cggcaaataa 2794921 aacgccatac accgacatca gaaaatggcg gtaaaattcc tgcagcacgt aaccgccgtt 2794981 ttgcgaatag tatgtgccaa gctgctgtag tacttccata tgatccacct cttttcttag 2795041 tcaaaataat gatgtttctc taaaaattcc tttgctacga cagacggctc cttcagcttg 2795101 ccatccacct cataattaag ttcctgcatc gtttccgtgt cgatttgccc aatcagctta 2795161 ttgatcacac cttcaagttc cggatgctcc ttaagcacct tttccggaat caccggtgaa 2795221 cagtcatacg gcggaaagaa acgcttatcg tcttttaaga ttttcagatc atatgcttta 2795281 atccgtccat ccgttgaata agccaaaacc gcatccattt tcccgttttt gactgcgtca 2795341 tagactagcc cgatctgcat tggataagtt gtgccgaact caaagccata tgtgctgaca 2795401 aagcctttat acccgtcgcc ttttcgtttc agccaagcat tgtcgacgcc taatttatat 2795461 tgggaagcat ttttcttcag gtcagacacg gtgttaatat gctccttttc cgcaaacttt 2795521 tttgttacgg tgaaggcata tgtgttatca aagccgtagg aatcaaacca tttataagaa 2795581 aagcgctttt gaaactcgtt ctgcacaatg ttcagcgctt ttttcggatc tttctccgct 2795641 tccttgccga gggtgcttgt taaatctgtt ccggaatagc gcgtggctga aatatcaatg 2795701 tcaccgccca gcatcgcttg gtgctgaaca tagtttgagc cgaggttttt cactaaagca 2795761 gtattcaaat ctgtatcatg ttcaataagc tgcgcgatca tattcgctac aatttctgat 2795821 tctgtcatgc tctgcgcccc gattttgatc gtatcgtcag aagcgccgcc tagacccggc 2795881 agagagcagc cgcctagcag catgacaaag acgagagcaa acgcgccaag ccatttgatt 2795941 tttgtcattt tcaacagtgc caactcctta cgatacttcc ttcatccctt gcaagccttt 2796001 cggcgtcacc tttcgttctg tcacagccag aacataatca ataataattg ccagaattgt 2796061 gacaggcacg gcaccgccaa tgatatattc aggctggtat aggttcagtc cgataaaaat 2796121 atagtccccg aggccgcctc ccccgataaa cgacgcaagt gtcgcccagc caattaggta 2796181 gatcgttgat gtgcggatcc ccgccatgat gatgggaatc gccagcggga tttcaacgag 2796241 ccgaatctgc tcccagccgg tcatgccaat tcctttcccc gattccagga ggtttttatt 2796301 tacaccttta atgccggtat acgtattgcg caggatcggc agtaccgaat agaaaaataa 2796361 agcgacaatc gcaggcactt ttcctacgcc gagaagcgga ataaaaaagg ctaaaatcgc 2796421 cagactcggc agggtttgca caatgtttac gaaaccgata accgcacctg cgcctttttt 2796481 cattctggta agagcaacgc cgagcggcac tgcaacgata atgcccaata caacggctat 2796541 gagtgaaata tataaatgct ctcctgtttt atacagcagc tctccgccgt tcgtttgcaa 2796601 aaaagtcatc atttgattca tcttaaaaga gctcctcccc tggtcagatc gtcatgagct 2796661 ggttttcctc gtcgccccaa atggaatcgt atacgatatc aacgaggctc gctcttgtca 2796721 caatccctgc taaatggttc tgttcatcga ccaccggaac atacttgatc ccctgcttca 2796781 aaatttttcg gactgtatcg cgaagaagcg cccctttttg aacggtatat atatctgaac 2796841 ggtatacatc gccaacgatg ctcgcttttt tgcggttttg atcaatcatt tccacatcaa 2796901 catagccctt cagcacgttt tgccggtcca caacgagcag cgagtcaaca cgtttttctc 2796961 tcatcagctg aatcgcctga gaaagcgttt tgtccgcaga taccgtcacc ggcgttctgt 2797021 tcatcatttg ctctacccgc tcgatatccg gtcttgactg aatcaggcgc tctttcccga 2797081 taaattcttc aacaaactca tttgccgggt ttcgaagaat ctcatcaggt gtgccgactt 2797141 gaacgatttc tcccgctttt aatatcacaa tcctgtcagc aagcttaatc gcttcatcca 2797201 tatcgtgggt tacaaacaca atcgttttgt ttaaggttct ctgcagtttt ttgaattctt 2797261 cctgaaggga atcacgcgta atcggatcaa gcgctccgaa cggttcatcc attaaaatga 2797321 gagggggttc cgctgccagg gcgcgcagca cgccgattct ctgctgctgt ccgccgctga 2797381 gctcatgcgg ataacggtct aaatactctg ggcccatatc cacaagcttt aacagctcgc 2797441 gcgcccgttc tttccgtttt tcctcaggcc atttcagcag ctttggtacg agtgagatgt 2797501 tctgctggat ggtcatatgg gggaacaaac caatctgctg tatcacatag ccgatttttc 2797561 tcctcagctc aaccgggtcc tgttccataa tattttctcc gtcgataaag atccttccag 2797621 acgatggttc tatcagtctg ttgatcatct tcatcgtcgt cgtttttccg cagccgctcg 2797681 ggccgataaa acagataaat tcaccttttg caatatctaa atcaatgctg ttcacagctt 2797741 ttttgccgcc tttatatact tttgacactt gttccaattt cagcaatccg tgcacctccg 2797801 caggtttcct ttaaattttc tgaaaagtat aatccttatt atagtttgaa ctttgtaaaa 2797861 taaaaagttt acaatgtgtt gaaattatat gttatttata gattatttat tgttatgacc 2797921 gagacggaaa gggtgttctt acaattactc cggatacctc ccacttcctc tgcattcagc 2797981 tattttcaac accaggaaga aatatgatat attgacacca tcaattgcca tttgaaggga 2798041 tgatcagctg tgaaaaaaac cgctctcgac atcattgaac atgctgaaga gcatctcatt 2798101 gagaagattg ccgaaaatat gcatacgttt ggaatgcctt caactgtcgg acgtgtgctc 2798161 ggaattattt atatgaatcg aaaaccaatg accttaagcg agctctctga ggcaacgggc 2798221 atgagcaaaa cacggatgag ccaggttgtc cgggaaatga tcgatgccaa tatcgccgaa 2798281 aaggtgtttg aaaaaggcgt acgaaaagac ctttatgacg tcgagcagga ttattatcaa 2798341 accttcattt ctttatttgc ggcgaattgg acaaaggtcg tgagcaaaaa caaagtgctg 2798401 tataaaaaat taaaccggga gctgagtgat cttttacaaa gggacgggct taccccggaa 2798461 gcggaagaga aagtcaatca gctgctgaat gaattaaaag aatggcttca ttactatgat 2798521 tggctgagca ggttgattga attttttgag agtgaggaag tctttcggta tgtgccgaaa 2798581 acaaaagaat gcagctctct aaaataagag agctgctttt tgcatcatga agttaagacc 2798641 ggaaacatgc ctttcagccc ggcaccaatc atcccgaccg caaccacggc taagattaat 2798701 cccatcagtc tggtaatcac attcatctcg gtttttccga gtttgctgct gataaaagca 2798761 gaatagtgga aaaagagaaa ggtcagggca ataacggcgg ctatgccgat catgacagcc 2798821 gcataatgac caatgccgct atgtccggcg gaaaggctca tcactgttgc aatcgttccg 2798881 ggcccagcaa tgatcggaat ggataaaggt gtgactgata tatccgcttt ttccttgctt 2798941 tccttatgtt catcatggtg aagagattgc acgtgcgatt ctttcgcatt caatagatta 2799001 taggcaatgc cgaaaatgaa tatgccgccc gccactcgga gcgcgtgaat gttgatatca 2799061 aacagtttaa agataagatg accgaaaacc aaaaaagctg cgagaataaa aaaggataaa 2799121 atagctgcct tccgggcaat cgcttttctt tccgctgcag tatagccttc tgtcagcgtc 2799181 agaaatatcg gtacgtttcc gatcggattc gatactgcga ataaagaaat gaagacgtga 2799241 acgataaatg agaacatcat atacctcctt gttgatagtc tctgcacagg aaatagaatg 2799301 attctccacc cttttacccg gaggcgattt cccggtaaac ctttatagcc tgtcagaaac 2799361 gcgccatgct acaatgaagt gacaaattga ataggaagga cgtatacaga tgttcaaaaa 2799421 aattgcggca gatgccttgg gcttatctga tatcggaaaa attatcgaac ctcaggacta 2799481 tgacaaaaca gacgcagatg actatgtcat gcatgaagat aatgagaaaa tttatttctt 2799541 gattaaaaca aaagcagacg agtattgctt tacgaacctg gccctgatcc atgtggacgg 2799601 cgaacgcgcc acttcctcaa aacgaacgtt gaaacgctat ccttattcgc aatataaaat 2799661 ctctgacgtt tttcttgaaa ctgccggaaa agtggatttg gatgttgaaa ttaagttcaa 2799721 gctgggcggt gaacaattcg acattgatgt ccacaaagac cagattgaaa agttaaaaga 2799781 cctttataaa gcactgcttc gcatcgctga aacaacctat gaaaatgaca ttttaatcaa 2799841 tcaagcggag caaagcttag ataaagcagt gacgattctt caccataccc gccctgagca 2799901 cgtcaatatt gaaacgcaat acaaagagct gaccgaattc ggattcactt ggctgacatc 2799961 cgttcgctcg cagtatcata ttaaggattt tggggatgta tttgagaaat atattaataa 2800021 ctagataaaa aaagacacag ctgctatcgt gctcgtgtct ttttttgtat gaatattgat 2800081 tactttacaa cttttttctt ttataataaa actattagtc tattttccct atattacaga 2800141 taaaggagtt attttatgta ttgtcctcaa tgcggccatc aaacagatgg cggaaatttt 2800201 tgtgagaaat gcggatcacc gctccccggt caatcaggcc accagcatgc agctcaaact 2800261 ggagccgctg caaagcaagc agcaaaacag ttcggttcat ttgtcttatc cgtcctgaaa 2800321 cgcccttatc aggaatgtaa agcaacaggc ggagaacagc tgatcagcgc aatcattacg 2800381 atggttcttt tcagtttgct gacccctttg atgttttata ttcttttttc agacggtccc 2800441 ggaagcgtaa gctttacagc aatcttctta gagccaacca tttattttat tttatttcta 2800501 tttggcctgc atgcatgcat ctttttcgcc ctgaaaatcg cgggaaacca agtgtctttc 2800561 aaggattcat tctcaagatt cggagcattt cttattcctt ttacggctat tttgattctt 2800621 gcccttttct tctttttatt acatacagac atttgcttta ccatattagc cgttggttta 2800681 atcggtgcat tcttcgccat tcctcctgcg atgctgagca gttaccagca ttcatataaa 2800741 gggaaggttg atttcattta ctcaacgatt gtgatttatc tgatcatctg cgttacattt 2800801 cagcttatta tcgaacacta tgtcaaagaa attttccgtt atatgctctt ttaaaaacaa 2800861 ccccatcacc tgctggtgat ggggttgttt tattgaatag acgttaagta aattcttccg 2800921 ttcttcacta cgccggtgta ggtccagtta tatgttctga gctttggact gccgcctgat 2800981 tttgtgatat agaattcttc atacgtctta atcgtgatag ccgacccatt ttggctccag 2801041 cttttcactt catagttatt aaagtcttct gttgtcccct ctttatttaa tttcgacacg 2801101 agatgctgct ggtcggaata aagggaactg cctttttcaa ggctgtcttc catcagtgag 2801161 aaattatttt gattcacggc atctgcctga ctttgcagat aactgcccat aaataatgtc 2801221 acttgttcat ctgtaacatc gccgcttgca gagctttcac tgcctttgtt tttcgagcca 2801281 gcccaggcgg aagtgtatgt ctctggttta tcatttttga ttttctttat atttgtgcct 2801341 gcagattcga atgttgattc tgcatcttcg aaaatccact ttttctgttt tttatcatat 2801401 gaaagaagat attcataact cggactgtcg tcagtcattt cagactttgt atagtcgtta 2801461 tacgaagaag actggtgaag ttcttttcct gttaccgata cctgccacgt tccgtcgttt 2801521 ttctgagaga gggcaaatgt gtccaggtca aaatcagttt ccaagtatct atcttttaag 2801581 tatgaatccg cgcttttcat agaatcgacg gtgtccttcg tctccgcctt ccaattggca 2801641 cttgcctctg tcatctgggc tgtattccca tcagatagag ctttggagta ttgttttgtt 2801701 gttttgacaa ttgtgttcat aatctgttcc tgtgtatctt gatcaggaat taacgttaac 2801761 tccatttctt tatcatcgat cggaacgccg gcagtttttg tttttcccca cggaaattct 2801821 gcctcgactg aagctgtcat tgatccatct gtcagcagcg gaccatatgt tacggatttg 2801881 aacggatctt tatgaattga tttaccgtta atcagcaaat ctcccttccc gctcttgatg 2801941 tcattcgcta agctgaatgt cacatcgtct gcttccaatg agagatcaac acgaaagctg 2802001 ctatcgccaa tcgcctgaat gtcttccttt ttcacaaggt caacgacatc gtttttcagt 2802061 ttggctgaga ctgtatattc gccgggaatg tacggaccaa gggtttgtgc ttgatctgct 2802121 ttctttacag atccggcttc ctctttattg acatatagat cggtattttt ataattgctg 2802181 ctcacttcaa aataaacagg tgctaccttt aagtcataat ggtcaaatac cagcaggctt 2802241 ttcccgtctt tttccgcata tacgatatcc ttctgggctg tttcatcacg cagcgatgca 2802301 aaaagttcat cttttttgtc tggatgatcc ttcaaatatg taagaaacgg ttttacatta 2802361 tttttagtga gtttaagatt gtcatttacc ggtgtaagca gagtcgcgat ttggtcctga 2802421 tccccatcat ttacggcctg ttcaaacttg tctactaacc tatcctttga agtaaaatac 2802481 gctccggttt tatatgcggc gaataatata acgcacgccg cggcaatgct gctccataaa 2802541 atgatggttt tcttagggat cggttttcgc ggagcctgcc tcgtttctgc agtgctagct 2802601 gtttcttgat ttgcctgttt gctgccccct ccgatcgggg tgccgcattg tttacaaaac 2802661 ttggctcctt cattattctg ggagccgcaa ttcttacaaa ataacatgac tttcctccta 2802721 ttctactaat ttgataacat ttactgcttt tcatatttta taataaaaca gaatgaaatt 2802781 gggaacgaat gaaaaaatta aatgtctatc agactaaaaa ggtggaatga atatgcaaaa 2802841 gctcaggatt gaattaggag aagaaacaaa tgacgaatta tatgatctat tgctgctcgc 2802901 cgatccatcg aaagacattg tagatgaata tcttgagagg ggagaatgtt acacagcttg 2802961 ggccggtgat gagcttgcag gggtttatgt attgctaaaa acaaggccgc aaacagttga 2803021 aattgtaaat attgcggtaa aagaatctct tcagaagaaa ggctttggca aacagcttgt 2803081 acttgacgcc atcgaaaaag cgaagaagct gggggcggac acgattgaaa tcggaacggg 2803141 gaattcgagc attcatcagc tttccctcta tcaaaaatgc ggattccgca ttcaggcgat 2803201 cgaccacgat ttctttctca gacattatga tgaggacatt tttgaaaacg ggattcaatg 2803261 ccgcgatatg gtaaggcttt atttggatct ctgaaagcat aaaaaagccg ccgagagaaa 2803321 atcccggcgg tctttttatt acttgtttaa gttgtagaaa gagttgatac cgtggtattg 2803381 agcagtttca gccaactgat cttcgatgcg aagaagctgg ttgtatttcg caacacggtc 2803441 cgtacgagac ggagcacctg ttttgatttg tcctgcgttt gttgccacag cgatgtcagc 2803501 gattgtgctg tcttcagttt caccagaacg gtgagagata acagctgtgt agcctgcgcg 2803561 tttcgccatt tcgatcgcat cgaatgtttc agtcaatgta ccgatttggt ttactttgat 2803621 caggatagag ttgcctacgc cgtttttaat accttcagaa agttttttcg tgtttgtaac 2803681 gaagaggtcg tcaccaacaa gctgaacttt tttgccaaga cgctcagtaa gaagcttgtg 2803741 gccttcccag tcgttttcgt caagtccgtc ttcgatcgag atgattgggt atttagaaac 2803801 aagctcttca taccagtcaa ccatttcagc agatgttttc acaacgcctt cgccagacag 2803861 atggtatttg ccgtcttctt tgttgtagaa ctcagaagat gcagcatcca tagcaagttt 2803921 aacttcttcg ccaggtttga agccggcttt ttcgattgct tcaacgattg tttgaagcgc 2803981 ttcttcgtta gaaccaaggt ttggagcgaa tccgccttcg tcacctacag cagtgtttaa 2804041 gccttttgcg cttaatactg atttcaggct gtggaagatt tgagcgccca tgcgaagtgc 2804101 ttcacggaag ttaggagcac ctacaggcat gatcatgaat tcttgaatat ccacgttgtt 2804161 atcagcatgc tctccgccgt ttacgatgtt catcatcggt acaggaagcg tttttgagtt 2804221 gaatcctcca aggtattggt aaagaggaat ctgtaagaaa tcagcagcag cacgcgcaca 2804281 agccatagat acgccaagga ttgcgttcgc accaagtttg cctttgtttt cagtaccgtc 2804341 aagctcgatt aaaagctgat cgattgcgtt ttgttcagtt acatcaaagc caagaagctc 2804401 tggagcaatg atttcgttta cgttgttaac agctgttaac acgccttttc caaggtaacg 2804461 gtctttgtcg ccgtcacgaa gctcaaccgc ttcgtattca cctgtagaag ctccgcttgg 2804521 cactaatgcg cggccgaaag ctcctgtttc tgtatatact tcaacttcaa ctgttgggtt 2804581 gccgcgggag tctaatactt cgcgtgcata aacatcaaca atgtatggca tgagttttgt 2804641 ctctcctttt gattttcaaa ttatttttga attaaagatg ttcctgtcat ttctttcggt 2804701 ttttcaacac caagaaggtc taataacgtt ggtgcaaggt cgcctaggat tccgccttca 2804761 cgcagcgtaa tgccttcttt cgttacaatc acagggactg ggtttgttgt atgcgcagtg 2804821 tgcggttcgc ctgattctgt aatcagaatg tcagcattac cgtgatcagc ggtaatgata 2804881 gcgtgtccgc ctttagcaag gatcgcgtca acgacttcgc ccaagcattc gtccactgct 2804941 tcaattgctt taattgttgg ttcaaccatt ccggagtggc cgaccatatc agggtttgcg 2805001 aagttaagaa tgatcgcgtc atgcttgtca gcttcaattt ctttgacaag cgcgtctttc 2805061 acttcatacg cactcatctc aggcttcaag tcatacgttg caactttagg cgagttgatg 2805121 agaatacgct cttcacccgg gaattcagct tcacggccgc cgctcataaa gaacgtgacg 2805181 tgcggatact tttcagtttc tgcaattcga agctgtttta acccgtgctg agataatact 2805241 tctccgactg tgttatcaag atttatcggt ttaaacgcta catagccgtc aactgtttca 2805301 ctgaagtgag tcaggcagac gaaatacagg ttctttggat aattctcgcc gcggtcgaag 2805361 tcacggaagt ctttgtttgt gaacgtgttg gaaatctgga tggcgcggtc cggtctgaaa 2805421 ttatagaaaa tcacagaatc gccgtcttgg attttcgcaa caggctcacc gttttctttt 2805481 gtgatgacag atggaatcac gaattcatcg tagataccat ttgcatatga atcatcaaca 2805541 acatccaggg cgctgcggta agatgggcct tcgccgtacg ccattgcgcg gtacgctttt 2805601 tctacacggt cccagcgttt gtcgcggtcc atagagtagt aacgtccgga aatgctggcg 2805661 atttcaccta caccgatttc cttgatttga tcgttcaact ggttgatgta cgttttcgct 2805721 gtctgcggac ctacatcacg gccgtcaagg aagccatgga tataaacctt tgtcagccct 2805781 tcttttttcg caagctttaa cagtgcgaat aaatgattga tatggctgtg cacgcctccg 2805841 tcagataaaa gaccgaacag gtgcaaggct ttgttgtttt ctttcgcgtt gctgatcgcg 2805901 tcaaggaatg tttgattgcg ttcgaactct ccttcacgaa tggcaacatt tacgcgtgtt 2805961 aagctttggt acacaatacg tcccgcaccg atatttaagt gacctacttc ggagttcccc 2806021 atttgccctt caggaagacc tacagcctcg cctgaagcag tcaaagtttg atgaggatac 2806081 tggttccaat agcggtcaaa attcggtttt ttcgctaaag cgactgcgtt ccctactgtt 2806141 tcgttacgta atccgaaccc atcaagaatg atgagtgcag ctggtttttt actcatattg 2806201 accttcctcc aataattgaa cgaatgactg tggctcaagg ctcgcgccgc cgaccaaagc 2806261 accgtcaata tcggactctg ccatatattc tttaatgttt gcaggcttta cgcttccgcc 2806321 atattggatg cgaagcttgt ctgcagcttc ttggctgaag ctttcagcga cggttttacg 2806381 gatatgcgca cacacgtcat tcgcatcttt cgctgtagaa gatttgcctg ttccgattgc 2806441 ccagattggc tcatacgcaa taacagaagc agcaacttgt tcttcagaaa gaccagcaag 2806501 gccttttttc acttggtcag caacaagatc atttgttttg ccggcttcac gctcttcaag 2806561 cgtttcacct acacagatga tcggcacaat gccgtgtttg aaagctgcgt gtgctttttt 2806621 gttaactgtt tcatcagttt cagcgaacat ttcacggcgc tcagagtggc cgatgacgca 2806681 gtagtcaacg ccaaggtctt tcagagcaac cgggctgatt tcgcctgtga acgcgccgct 2806741 ttcttcgaag tgcatgtttt gagcgccgac ttttaggtca gtgcctttca cagcagaagc 2806801 aagcttttct aagaaaagcg ctggcgcgca aacaacagct tcagctttgt ctgctgctgg 2806861 aatggaagat ttcacttctt caacgaagct gacagcttcg ccgagtgttt tgttcatttt 2806921 ccagttaccg gcgataattg gttttctcat ctgttccact tccttatagc agttttgaga 2806981 ttatttatcg ttcagtgcag ctacccctgg aagctctttg ccttccataa actcaaggga 2807041 tgcgccgccg cctgttgaga tgtggctcat tttgtcagca aggccgaatt tttcaaccgc 2807101 tgccgcagag tctcctccgc cgatgacaga gtatgtatct ttcgcctctg ccaatgcttc 2807161 cgcaaccgct tttgttcctt gagcgaacaa gtcgatttcg aatacgccca ttggtccgtt 2807221 ccacacgaca agtttgctgt ttttgatgac gtcagcatac gtttcgcgtg ttttcgtacc 2807281 aatgtcgatt gcttctaaat cactagggat ttcagagatc ggcacaattt tcacgtttgc 2807341 atcgttagag aaatcatctg caacgagtac atcttcaggc atgtagaagt taacgccttt 2807401 ttctttagcg cggtccataa atgatttcgc aagctcgatt ttatcctctt caagaagaga 2807461 tttcccgact tcatagccaa gcgcttttac gaaagtataa gcaagacctc cgccgatgat 2807521 caggttgtct actttatcaa gaagactttc gattacaccg attttgtctt ttactttcgc 2807581 tccgccgatg atcgctgtga acgggcggtc aggattggaa accgcttttc caagtacatc 2807641 aagctctttt tccattaaga aacctgcaac tgctggcaga tgctcggcaa ttccagctgt 2807701 agatgcgtga gcacggtggg cagcaccgaa tgcgtcattt acatatacat ctgcaagctc 2807761 agcaaatgct tttgcaagct caggatcatt tttctcttca ccaggataga aacgtacgtt 2807821 ttccaataca agaacgtctc cgtccttcat ctcagaaatt tgtgctttta cagcatcgcc 2807881 gtatgcttca tccgcttttt tcacttcttt gccaagcagt tcgccgagac gtgcagcgac 2807941 aggagttaaa cgaagctcct caaccacttc gcctttcggg cggcctaagt ggctcgcaag 2808001 aaggactttt gcgccttggt ctgcaaggtg tttgattgtt ggaagcgcag cacggatacg 2808061 tgtatcgtct gttacttccc cgtctttcat tggaacgtta aagtcaacgc ggcagaatac 2808121 aactttgcct tttacgtcga tgtctttgag agttttttta ttcatgccta ggagatcctc 2808181 cttcaaaatg gtttgcatac agcacgaaaa acgtgaaacc gtctgttcaa gcgataactc 2808241 cgctagggca gatcgcagtc tttttcggca cagggcagtt cgtctaaaag ccagggcagc 2808301 ggccttaggc gaaagcgccg gcaaagctgc ttaaaacgcg gtcgtttctc tatcacagag 2808361 cgttttctga aagccggtct tcatggaaaa agggaaaggg agtccgtccc cttcccttgt 2808421 ccgctttcat tatagcgctt ctattcgaaa gaaccaagtc aggtcctttt tcagctataa 2808481 attaaagacc tttttttgcg atgtaagctg caaggtcaac aacgcggtta gagtagccgc 2808541 tttcgttatc gtaccaagag attactttta ccatgctgcc ttccataacc attgtagaaa 2808601 gagcatcgat tgtagaagag tttttgtttc cgttgtagtc gccagaaact aatggctctt 2808661 cgctgtagcc aaggattcct ttaaggtcgc cttcagccgc ttctttaaga gctgcgttta 2808721 cttcttcagc tgttacttct tggttcagtt cagcaaccaa gtcaactaga gaaacgtttg 2808781 gagttggaac acgcattgct ccaccgttca gtttgccttt tagttcagga agaactagag 2808841 aaactgcttt agcagcacca gttgatgttg ggatgatgtt ttcagctgct gcacgcgcac 2808901 gacggtagtc tttgtgcgga agatcaagga tttgctgatc gtttgtgtaa gagtgaacag 2808961 ttgtcatcat accgcgtttg atgccgaatt tatcgttaag tacttttgca aacggcgcaa 2809021 ggcagtttgt tgtgcaagat gcgttagaga taacatcgtg gttagccgca tcgtatttat 2809081 cttcgttaac acccataacg attgtgatat cttcttcgtt agcaggagca gagatgatta 2809141 cttttttcgc gccagcttct aagtgtttcg cagcgtctgc gcgttttgtg aagaaaccag 2809201 tagattcaac tacgatttca acgccttgtt tgccccagct aagtttagca ggatcgcgtt 2809261 ctgcagaaac ttcaattgtt ttgccgttaa caacaaggtt gttaccgtca actgaaactt 2809321 cagcgtctaa ttttccgtgt acagaatcat attgtaaaag gtgagccagc atgttagcat 2809381 ctgttaaatc gttaaccgct actacctcaa cttcaggatt gtttaatgct gcgcggaata 2809441 cgttacgtcc aatacgacca aaaccgttaa taccgacttt tactgccatg attgtttcct 2809501 cctttaaata agtgagagat atttatattg agggattatt catcccttaa taacttcttt 2809561 gcggctcctt cgtctgtgac gagaaccgtg ttgcgtggct ttttaaagta agcctcgatc 2809621 gcttcggctt ttgatgatcc gcccgctacc gcaataatat cggggatggc gtctatgtca 2809681 tccagctgca ttccgacaga atgcactttg tgaaccactt cgccgtccgc gttaaaatag 2809741 tagccgaacg cttccgtcac cgcgtcgtta tcatctattt tctttaaatc ttctaaaggc 2809801 gtgtttctgc gctgagccat agttttagct tcgccgattc cgtgaaccag catactcgct 2809861 gatttaatgg tgttcagcac ctctttgaca gaaggctctt caataataga tgaataggcg 2809921 ccttgtgaca gctgtcccgg aacaaacaaa agccggtaag tgcctgaagc cttctccgcc 2809981 atatgcgcgc atatggtgtt cgcctggttt ttcacgtctt cgcctaaacc gcctcttgca 2810041 ggcacaaaca aaagctcgcg gtttttagaa tccggcgtca tcatttcggc gacagcttca 2810101 attgtcgtac cgccagttac agcgacgata tttttgcctg aaaatctttt tttcatacat 2810161 gcgacagccg ctcttcccat ttcttttttg acccatgggg attgatcgct gtctccggat 2810221 acgataatgg catcctttag atttaaacgt tcttttaatg tcttttccaa aagagtcaaa 2810281 cctaaaacat ctttcatcgt atcttccaaa acagaaagca gttcatagcc ctcttctgtc 2810341 aatgtcatgc cgtttgtctt aatatcgacc aggttctgtt cctttaaaaa ctgaacctcg 2810401 cccctcagca cacgctcgct gattccgaga ctggcagaca ggcttcttcg cccgatgggt 2810461 tctgtcagcc tgatatactg caagatttca aacctctttt gcataacgag cagaagatca 2810521 ggcaataatt ttttttgagc ttgtattaac tggttcatga ctcaaacgtt ccttcctttt 2810581 ttgctggaca ttatatgtcc cgctatgaca aaaaacgtcc cgtcatagcc aaaaaaaatc 2810641 atttctgctt tctttaatta ttttaacagg gtggaattgt ttattcaact gttaagagcc 2810701 aattcatcga caatattcgc agagttttca tgccgcgtcg ttttatccag caatatttta 2810761 tcctatatat ctttatctta tacagaaagc gccaaatggt gcatcccaat ataaacagcc 2810821 cttcccgtag aaagggctgt ttcattaaag cgttttcatt ttatccaaag cttttcaatt 2810881 tcctcgagcg atttgttctt cgtttctgga cagatcgtaa cgacaaacag gaaacaaagg 2810941 atgttaatca ccgcaaagat ccaaaatgta taggcgagcc cgaaagaatc gatcatcatt 2811001 ggcacaaact gtccgatcgc ccagtttgct ccccataaaa agatggtcgc aatgcccgcg 2811061 gcccgcgcac gcagatggtt cgggaagatt tcagaaatca taatccatgt gatcggtccg 2811121 accgagacac agaaagcagc gacaaaacct aatataagga cgatcatcat gatcccgctt 2811181 gttaactcaa aataaaacga cgtcccgatt aaaatcataa aaatagccat aaaagcagaa 2811241 ccgatggaca tcagtttttt tcgtccgact ttatcaatca gcaacaccgc aataacggta 2811301 aaaataactt ctacaacccc gacgatacaa gtcgtcacaa atccggcgtt ttgcccgaat 2811361 cccatcattt taaagatttc cggcccgtag taagtaatcg cgttcatgcc gatgacttgg 2811421 ttaaacagcg ccagcaggat tccaatgaca agcgcctttc tgagacccgg cttaaacagc 2811481 tgggagagcg accccatttg ttctattttt aaagagttct caatgttctt taattcttct 2811541 tttgcaacag tttctccatt aatacgtgtc aggatcttta aagcttcatt tgttttgccc 2811601 gctttcgcca gccatctcgg actttccggg acgacgagca ggacaaggaa aaaaatgacg 2811661 gatggcacca ttccataagc aagcatccat ctccagccgg tgtgcacgcc ccattcgtat 2811721 gttccggacc gctgcacagc tagattaata aagtatgttg cggaaatacc cagtatcgta 2811781 aagagctgat ataacgaaga taaacttccg cgtatagcgg gcggtgccgc ttctgtaata 2811841 tacgtaacag agagcgatga gcccatcccg attcccagcc ccccgataat ccttgcaatg 2811901 attaaggtgg acacgtcttg agaaagcgct gaaacgattg ctgatatcgc aaataacaaa 2811961 gcggctgtca ttaaaatttt tctccggccg aatctgtcac ttaaaaatcc ggatatcccg 2812021 acgcccacaa ctcctccaat cataatgctt gaaatgacaa gtccctccat aaacggactc 2812081 aggctgtata aatctttcag aaaaccgatg gcgccagaaa tcactgccgt gtcatagcca 2812141 tacaataagc cgccaagccc cgccgcacat gagatcaaaa tgacaaatcc cattgaatgg 2812201 cttcttgtta caggaacatt tggttctaat tgagttggag tattcttcat ttccctgccc 2812261 tcccgaatgt tgagtaaagc gttttcattt aaaccttcaa ttgtacgtac ttatattaaa 2812321 atttaacgaa aattacattt aattagtacg tacaaatata gaataatctt gtttgcattt 2812381 tctgtcaatg ttttcttaca aagaacgctg tgatatactg aaatttgtcc gtatacattt 2812441 tggaggaatg gatatgttac caaaatacgc gcaagtaaaa gaagaaatca gttcttggat 2812501 taatcaaggc aaaatactgc ccgatcaaaa aatccctacc gaaaacgaat taatgcagca 2812561 attcggcgtc agccggcata ccatccgcaa agcgatcgga gacctcgtat cacaaggtct 2812621 gctgtacagc gtgcaaggcg gaggcacctt tgtcgcttca cgctctgcta agtcagcgct 2812681 gcattccaat aaaacgatcg gtgttttgac aacttacata tcagactata ttttcccgag 2812741 catcatcaga ggaatcgagt cctatttaag cgagcagggg tattctatgc ttttgacaag 2812801 cacaaacaac aacccggaca atgaaagaag aggcttagaa aacctgctgt cccagcatat 2812861 tgacggactc atcgtagaac cgacaaaaag cgcccttcaa accccaaaca tcggctatta 2812921 tctgaacttg gagaaaaacg gcattccttt tgcgatgatt aacgcgtcat atgccgagct 2812981 tgccgcgcca agttttacct tggatgatgt gaaaggcggg atgatggcgg cggagcattt 2813041 gctttctctc ggccacacgc atatgatggg tatttttaaa gctgatgaca cacaaggcgt 2813101 gaaacggatg aacggattta tacaggcgca ccgggagcgt gagttgtttc cttctccgga 2813161 tatgatcgtg acatttacaa cggaagaaaa agaatcaaaa cttctggaga aagtaaaagc 2813221 cacactggag aaaaacagca agcacatgcc gacagccatt ctttgttata acgatgaaat 2813281 tgcgctgaag gtgattgata tgctgaggga gatggatctt aaagtgccgg aggatatgtc 2813341 tattgtcggg tacgatgatt cacatttcgc ccaaatctca gaagtgaaac taacctctgt 2813401 caaacatccg aaatcagtgc ttggaaaagc agccgccaaa tatgtcattg actgcttaga 2813461 gcataaaaag ccgaagcaag aggatgtcat atttgagcct gagttgatca ttcgccagtc 2813521 cgcacgaaaa ctgaatgaat aaaaaaagca atgtatgggt ctccccgcta cattgctttt 2813581 tttatagctg ttatctgttt ttccaaacgt cagcgatgat ttcaaacgaa cgcattctgt 2813641 ctgcgtgttc aaaggtttct gagttaacca taatttcgtc agcctgtgtc gttttgacga 2813701 aatcttcaag cttcgccttc acttcttccg gacctccgac aatcgtggag ctcagctgct 2813761 cattgaccat cgctttttca tacgggctcc agatttggtc catatcctca acaggcggtt 2813821 taagctggtt aggcgtaccg cggacaagat caagaaacct ttgataatgg gaagtcgcaa 2813881 ggtgctgcgc tttctcgttt gtatctgccg cgataatggt gacaccgacc atcgcatacg 2813941 gttcgtcgag cacgtctgac ggcgtgaagg aattgcggta cagctccaaa gcgggaaccg 2814001 tattcgccgg tgagaaatgg gccgcgaacg caaacggaag accaagttcg ccagccagac 2814061 gggcgctgaa gccgcttgag cccagcagcc aaatcggcac atctatgccc tctccgggaa 2814121 tggcgcgaac ttgattgcgc acatttcctg acggtttaaa ataattgcgc agttcctcta 2814181 attgttctgg aaaatcctcc ccgctgttga tgtttctgcg gagcgctctg gctgtcaatt 2814241 ggtctgttcc cggcgcacgt ccaagcccca gatcaatccg cccgggatac agtgtttcca 2814301 gtgtgccgaa ttgttcagca atgactaatg aagagtggtt ggggagcata atgccgccgg 2814361 aaccgacgcg gattttcttc gtgcctccgg caatatggcc aatcaaaact gcggtggcag 2814421 agcttgcaac accttctata ttatgatgtt cagcaagcca gtaacggtga tagccccatt 2814481 cctctgcccg gcgcgccaag tccatgctgt ttcggaatga ttctgcaatc gttcctccct 2814541 gaacaaccgg agataaattc aagacagaaa gcaaggtatc tttgcgttgg ttgttagaca 2814601 tattgttctc ctttgcaaat gtgttatcag taaacagccc aaagctgtca ggtcatgatt 2814661 gaaagaactt ctatcacacc ataacacaac tgcattcagg aataaaagaa tttgattcga 2814721 tgaaattcga acaatataaa acgaacggtt tggaacatta ttctgctcca aacaactcct 2814781 tagccatctc aataaagagc ttagccgcca gagaagcctc ctttagcgac ggaacagcaa 2814841 gctgcacatc acggtatacc tgcgggtcca attccctggt caccacatgc tctggcagcg 2814901 gcatccccga catggacatt tctgataaaa tggccaggcc caggccttct ctgatcatac 2814961 tgatcgaggt gttgatgtta tagaccgtga aagctgggtg cagcgtagca cccgcctgcc 2815021 tgaacatatc gataaatggt gattcatagc cgccgtcaca gacgatcatc ggttcatggt 2815081 caagatcttt cagcgtaatg gctgaatgac tggcaagcgg gtgatcgtcc ctgagcacga 2815141 cagccatttt gtcttttttc aaatgaatgt actccatctc ctctgttgga tacagaagaa 2815201 tcccaacatc tatcatccgc gtatgaagcc actccttgac ttcatttaca gttccctcgt 2815261 gcagcacgag ctcaagtttc ggatattttt gtttaaattc actgatcagc ttcggcataa 2815321 aataagccga ggcagttgag aatgtgccga tatggatcgt tcccagttca agcccttttt 2815381 ccgctgctgc tacctgctca actttttcaa tgccttttaa gacttctctg atgtgtacta 2815441 agatctgttt tcccgtatcc gtcagcatca ggccattgcg gcggtcacga atgatcagct 2815501 ttacatcaag ctcagcttcg atcgcagaaa tcgcatggct gacagccggc tgtgtcatgt 2815561 tcagcgcctg acccgctttt gtaaagcttc ccgtttcagc tattttcaca aaaaccttta 2815621 attgagtaat ggtcataaca atttacttat gctccttata aaaaagattc attttattta 2815681 tcttatgttc taccgtatca tatgatggaa aagttctaca aggagtgaat gaacaatgaa 2815741 gcagctccca aaaacgcgga cagctctcct gctcgcattt ctcgtcatca tgtggggcgt 2815801 caattggccg ctgtccaaag ccgcgctcgc ctattctccg ccattattgt tcgcgggcat 2815861 ccgaacgctg atcggcgggc ttttattagt catagtcgca ctgccgcgta ttcataaatt 2815921 acgcttaaaa gaaacgtggc cgatttatct tgtttctgct cttttaaata ttacattatt 2815981 ctacggcctg caaacgatcg ggctgaatta tcttccggcc ggcctgtttt ctgcaatcgt 2816041 cttcttccag cctgttctga tgggtgtatt ttcttggctg tggctcggcg aatccatgtt 2816101 tgtaatgaaa gtgattggcc tcatcctcgg ttttgcggga gtagccgtca ttagtgctgc 2816161 gggctttggc gggcatattt ctgtcattgg ggttctgctg gctctcggct ccgcagtcag 2816221 ctgggcgctc gggacagtat atatgaaaaa aacaggcagc cgcgtcgatt ccatctggat 2816281 ggtcgctctg cagctgacga tcggaagcgt gtttctgctt atctccggct tttggacaga 2816341 aagcttttcg gcgatccaat ggacagctcc gtttattacg agcctgctgt tcatctccgt 2816401 attcgttatc gcactcggct ggcttgtctt ttttacgctt gtcggttcag gagaagcaag 2816461 caaggtcgca tcttatactt ttttgattcc gctcatatca atcgtggcca gctccatttt 2816521 cctgcatgaa ccgctcaccc ttagcctctt ggcagggctg ctgctgattg tcacgagcat 2816581 ctgtctcgtg aatacaaaat caaaagcgca gaaagctgcg gcgattggta taaacgagaa 2816641 agctgcacaa taataaaaac cctcttgccg gatgcggcaa gagggtttct tatttactga 2816701 tgcttgcgtc ctttgaccaa atatgcaact gtaatcaaaa ggtagatcgc cgcagtaatg 2816761 ccggtaatga caattgatgt tgtcatgatg accccgatca gaatggcgag taatgccaca 2816821 atcgcaaacc atgtcgtgta cgggaaccat tttacataat aggccggtgt ttccgtttgc 2816881 tgttttctcg attttaaatg agcgaatccg atgatcagcc aaatgaataa aacggtatat 2816941 cccaatgatc ccattaaata attaaatgtt tggcttcctg cgaacagaga aatcaatacg 2817001 ccaatataga gagaagaagt gcacatcaga atcgcaaaca tcggtacgtt tttcgatgaa 2817061 agcttcgaga agacctttgg aagccttccg tcacttgcct gtgtatacaa aatgcgtgat 2817121 gatccgtata aacctgaatt catagaagaa atgatcgcca gcaggatgac tgcattcatg 2817181 atatgatccg cgcccggaat gcctaccatt ttaaagacca tcacgaaagg actttccgga 2817241 acggaattga cttggttcca tggaatcagg ctgacgatga tgaaaaacgg cagcaggtaa 2817301 aacgcgacaa tccgtgtcag tgtgctgcgg acagctttcg ggacaacctt ttccggattt 2817361 tttgtctctg caagcgttac accgataatt tctgtaccgc cgtaagagta gatgacgaca 2817421 agcatcgccg tgatcagccc tgtgccgccg tgcgggaaaa atccgccgtg gtctgtcagg 2817481 ttggaaaatc cggatgctgt atgatcaccg aatgatacaa ataagagcag caatcccaga 2817541 ataataaaga taataataac ggtaatcttg atcattgcca gccaatattc agtttcggcg 2817601 aagattttaa cagaaagcaa gtttacaatc gtgacgataa gagaaattcc taatgccaac 2817661 acccagatcg ggcagcccgg cagccaatat tgaatgaaaa tcgcagctac aacagcttca 2817721 gccgcaatgt taagcaccca cattttccag tagatccagt ccaaaaagta agcagcgtaa 2817781 tttcccaata cctgctggac aagatcacgg aaggttctgg cgttacggtt tcgaacagcc 2817841 atttccgcca gcccctgcat aataaacagc aaaataatcc cgccgagcag gtatgcgata 2817901 atgacagatg gccctgccac atcgatcgct gagctgctcc ccttaaataa acctgcgccg 2817961 attgctccgc ccagcgccat catcataata tggcgggacg tcatcgtgcg ttttaacgtt 2818021 tgattgtcgt ttttcatcct cttctacctc tccttctcgt tttcaaaaac aaaaaagccc 2818081 gccgtctcct acctaatcta atagataaag agacgacgag ccttcggctg accgcggtac 2818141 cactcttgtt gattcttcat gaagaatcct gcttttgacc tgtaacgaag gttagccgtt 2818201 aaaacatagg gaatattcaa tctattccgt tccgtcttac cactcccggg cgagttcaaa 2818261 gaagaatcag gctgcgtcgc accaccccgc agctctctgt tctgatcact ttcttttact 2818321 gctcccaatc tatgtgtttt agttttctga aaaactcaaa ttttatgatc tgaatatatt 2818381 aacataatat acgtgcttct cttttaactg tcaataactt cagagaaaaa agaaactgtt 2818441 attttgtccc ttttcgaatg gctttccaaa aggattctga ctcgtttcct aatgcgtaaa 2818501 ctgaaacacc tgctatttta tattgctttg ccagatggct tttcgtttga acggtttttt 2818561 cgttttcata ccacacgaca tgtttatgct tctttttgtc aacataagaa aacgtcatcg 2818621 agcctgattt tttgttgaat gccggctttg ctttttgttt tttgatgagg gatttgagct 2818681 cattccattc ccttattgtg ctggtacttc cgtcttttac atcccagtca tagccgtacg 2818741 cagggattcc catgatgact ttattggctt tgatcttttt gactgaaaac tgcagagagc 2818801 ttttgatcca gtttgtgctt gccactgacc ccggctcacc ccaaatgccg tgttcatcgt 2818861 aggtcatgac ttgtacgaag tcggcatatt tgccgatttt cgcataatca tacggccagc 2818921 tccagtcatc atttttatca tcggcgcttt tggccggaac ggataccatt gttttaatat 2818981 gtttcttatt caaagcctgt gagacatatt gaatgaagtt cgagtatgca gcgcggtctt 2819041 ctggatttac tgcttcaaaa tcgatattga ttccgtaata tgagtgcttt ttggccagtg 2819101 taattaactg atctgtgaat cgttttttcg ctgttttatt gctcatgacc cgactcgcta 2819161 aatctccgtc aaaatcataa atggcatcat tatagtttga aatgacagcc catgtcttga 2819221 tttttttctt tttcgcatat gtcagctgct tagttggggc atcgccaatg atttgtccgt 2819281 ttttttcaaa cgcaaatgta tcggttgcga tggcattcat gtatgtatga tatttcgtaa 2819341 gagaattgta tgaagccgta tccccagtcg tgtagcctac tgtcataccg gctgccttcg 2819401 cttctccttt tgtatacata aacagaacaa tcgcaatcgc cagtgaaacc gctatgatca 2819461 gccatttttt catcgcattt cctcctgtat caagtcatac tcttctcatc ggccaaaaaa 2819521 ttggaagttg aagttttttc aagcaaaaag cccggcatat gcctgccggg cttcctgagt 2819581 tcagcggtca gagacgagaa tatatgctgc ctttactggt ccatgcaccc ccacaactaa 2819641 atccatttca atgtcggctg agttactcgg tccggtaatg tagttgatac atgaaggaac 2819701 agtgacaccg ttcgcaatgt tttggcggat gatatcactg gcttgtgtca ttctcggtac 2819761 aatgcttgat ttcggcacga tcgcaatata agtcgttggc aaaaggctga cagagcggcc 2819821 gatgtctttt gaggagaaga ggacaaccgt ccccgactca gccaatgtaa tttcgctgaa 2819881 tgtaatccct acattggctt gctccgcttt tttaatattt tcctcgcctt tgtcagcatc 2819941 ccactcccag accggcgttc cttcactcgg ccagtccttg gtgagcaggc ttttcagtcc 2820001 gtattcttca aagcgggggt ccttcggaat gatgacaggg cctccagaaa agcggctgac 2820061 ttgctcgcgc agggcatcgt aaaggccggt tgaatccgtt tcaatcagct ctgtatggat 2820121 tttgacacaa tggtttttga gcactgtgac taagtcatcc gctgaataac cttcaagtgt 2820181 tttatattgc ggctgatgcg cccattcagg gactgccacg cctcctgttc ttcgttcacg 2820241 gcccaggctg gatgcgattc ggtttaaaaa gctctcttga ttctgaatgg ttcccttcgt 2820301 catcactgct cctccttcgt gcgttcactt gtttctctgt ccgcaaacca gtctctgaat 2820361 ctcgatttat gcggtgccgg gaagtcgcga atctgggtcc aatttttaag cgggccgggc 2820421 cctttcgaaa ttttttcgtc ctctgtaaaa ggcgtcatgg cggccggcgc ccattttgag 2820481 cccattttgt aaagcgataa ggaggatgcg ccaagtccga atgctttcat tgcaagcttt 2820541 tcactgatcg gcgccctgcc ttctttttcg acgatattct gacgatgctt gagtagcagc 2820601 tcatgaagcg ggattttgac cgggcaggct tctgaacaag cagcgcacag tgaagatgcg 2820661 tacggcagct ccttataatc gtcataaccg ccgagcaacg gtgataaaac agctccgatc 2820721 ggccccgagt agattgagcc gtatgaatgt ccgccgacat ggcggtacac aggacagaca 2820781 ttgatacagg cggcacagcg gatacattgc agcacagact ggaattccgt tccaaggata 2820841 ttggatcgtc cattatcaac gatgacaaga tggaattctt ccggaccgtc cacttcacct 2820901 tccagcttcg gacccgtcaa agctgtaata tagcttgtca gccgctgtcc gacagcactt 2820961 ctagtcagca tgctgactag cacttcaaat tcagaaaatg acgggacaat ccgctccatt 2821021 cccatgacgg taatttgtgt tttcggcaag gtgctcacaa gccgtccatt tccttcattg 2821081 gtcacaaggc tgacggaacc cgtgtcagcg atggcgaagt tacagccggt aatgccgata 2821141 tccgcttcca gaaacttttt ccggagaatg gcgcgcgcat gcatcaccag ctcttccggt 2821201 ttttctgtat gttgatagtc cagtctttct ttaaacacat cgcgtatctg ctctttattt 2821261 ttatgaagag cgggcgctac gatatgtgac ggcggatcgt gatcatcaat ctgcaaaata 2821321 tactcgccga gatcggtttc tacgacttca cagccttcct tctccagcac ctcattcaga 2821381 ttgatttcct ctgtgaccat tgatttagat ttcacaattt tcttcccgtt cttcttttga 2821441 atgacatccc gaatatagga agacgcctct tccgctgttt tcgcgaaata gacatgtccg 2821501 cctcttttcg ccacattttc ggcaagctgt ccgagataga aatcaaggtt ttcaaggaca 2821561 tgctgcctga tttcctctga taatgagcgc cactcctccc agtttcccag ttcttctgct 2821621 gcctctaggc gccgcgtccg cagacgctcc tgtgcacctg aaacagcgcc tctcataaat 2821681 tcattatcaa tcccctgtga tacccgctct ttaaaagcgt cagtaccgat tttcatcgcc 2821741 atgatccttt ccccctctga atccagtttt atctgctgtt gagcacttcg gcgatgtgca 2821801 tcactttgac attcttatct tttcggccaa gccgtccccc gatattcatc aaacagccgc 2821861 agtcagcacc gatcagcacc tctgctcccg tttcctccac acattcgact ttttcatcga 2821921 ccatctgctc agaaatctgc gccatcttga ctgagaacgt tcctccgaat ccgcagcagt 2821981 tatgtttgcc cggaagctct gtaaactgca ggcccttcac atggctcaac agcttcatcg 2822041 gctccttccg aacacccagc agcctagtca tatggcacga cgtatgtaag gtcgcttttg 2822101 tatgaagggt cgcgccgaca tcctctaccc caaggacgtt cacaataaaa tctgtcagtt 2822161 catacgtttt atccgccagc tttttcgctt tatcggccca tttcggatca tcctgaaaca 2822221 ggtgcggata ctcccggaac atcgttgtgc aggaacccga aggactgaca acatattcgg 2822281 aatcctgaaa cgtttcgatc atccgtttca ttgctttttt ggcgtcatgt acatagccgc 2822341 tgttgtaagc cggctgtccg cagcaaatct gcccttctgg aaaatcaacc tcgcacccaa 2822401 gccgctccag cagctcaacc gttgcttttc cgacatttgt ttgaaacata tcaacaagac 2822461 aagtgacaaa aagtgagact ttcatgatga acccctctct catccccaat atatgatcag 2822521 gtcatctgat gacctgagtt aaaataacta tatgaatatc gtacactatt ctgacaatgg 2822581 aaggaaagag ttttctaggg atattttcat ttgtggcata tcaaaaacac tcccgatctc 2822641 ccaggagtgc agtatatggt tagatccagc ccttttcctc agcgatgctg gcggcttctg 2822701 tccgattttt cgcattaagc ttttggatga tttctgagat atagtttcga actgtgcctt 2822761 gagataaata gagctccagc gtaatgtctt ttgttgtctt gcctaaagcc gcaagcctca 2822821 gaatttcttg ctctctaacg gttagcggat tttcgtctcg catcatatta aacgtcagct 2822881 cagggctgaa gacacgtttt ccctttacac attttcgaat ggcatcggcc agatcgtcaa 2822941 tttcaccgtc tttcagcaga tagccatgtg caccggcctt tacggcgcgt tcaaaatatc 2823001 cggggcgggc aaaggtggtt aaaataatga ccttgctgac gcagcctttt ttcattaatt 2823061 cctctgccac attcagcccg cttcgaaccg gcatttcaat gtccataatg catacatccg 2823121 gctccagctt caaaatagca tgtagcgcct cttccccgtt taatgcttgt ccgatgactg 2823181 tcatatcctc ttctaaatca agcaaagatc ccaaagcgcc taaaagcatt cgctggtcct 2823241 cagcaataaa cagacgaatc attcttttcg tcctccaatc attctgcttt tttaataagc 2823301 ggaatcgtca gtgccacaac cgttccgtta tggtctgaaa ccgttaatcc cccttcaatg 2823361 agcatgagcc gttcttccat tccccacagg ccattcccaa acattttctc cttcggcgct 2823421 ccctttccgt catcccgtat tacgatcctc attttgtcag caaattgaga aatggtgatg 2823481 gcacagtggg ttgctttgct gtgcttgata atgttagtca cggcttcccg catacacata 2823541 ctgataatat tttgagtgac gggagatatc actgaaaagt cgtcggctcc ttcgtattga 2823601 aaggtaatgt tccccgctct taatatgtgc tgaatgttta cgagctcctc tgttatcgtg 2823661 accgttctca tatcagaaac cagctctcga acttgcttga gtgcggagcg tgaactggtt 2823721 tccatttctt ttgcctcaag cttggtccgt tctggatcag atgcagccag ccgctgaatg 2823781 agctggcttt ttaatgtaag cagcgacagg gtgtggccaa gagtatcgtg aagatcacgg 2823841 gcgattcgaa cacgttcctc ccttttagag agttctttta tctgttcgtt ggcttgtgca 2823901 agcttagctt caagctcaat cctccgaaac atagaacgaa ttccgaatgg agaaatgagc 2823961 ataatgacga gaaacgggag aacagaaaaa agctcccgaa gcgagaccga attcgcgata 2824021 aattggtata ggcatggaaa aagcagtata aagattaaag cgcagaacgc acggttaaaa 2824081 ttcgttttct ctttgtaata accaacaaag tttgccggaa aaaaacctaa gtatatatag 2824141 gtgatattgt aaaacacact atacatcaaa ataaccgcca tttgcacgat aagccaatat 2824201 gtaaacgaag ctttgcccac gctgcagaat aactggcgat atgccgctac aaaaaggagc 2824261 agcataccat atccgatccc ctgtttgacc cctgattctt ttaataaaga gaggaacggc 2824321 ataatcgtat acaccagaaa gatataaggg aaaaacccga attccttcgg gaaaatagat 2824381 attgcctttt tcatgtatta caccgcttct tgttttcttc ttatatattt agatagtagc 2824441 atgaagagca tcatataagc gattaatatc agaatatttt tccaagtcgg actcccaccc 2824501 cggacaagtt cccacgctcc gctcccgaaa tgataagacg gaagccactg gccaatgctc 2824561 tgcatcatgt caggcatgac ctcaaacggc atccacatcc ctccgcctaa agccagcagc 2824621 atataaagca cattactgat tccggccgct gtttctactt ttctcatgag gccgattagt 2824681 gtgcctaatg ctaaaaaagg caatgcgcca aacaaaatcc acagtccgct catcatccat 2824741 tcaaacggtg acaaggcaat atcattgatg attgcgccga acagaaatat gacggtaatt 2824801 gataaaacgt gaatgacact ttggccgatc atctgagctg ataaatagat atgatccgga 2824861 agaggcgtaa ggcggataaa ggcggcccag ccttgtgacc gttcttgtac cattcggatg 2824921 ccaagcgtca tgatagagga acccatcacg ctgaagactg tcatcgacat caggtaatgg 2824981 gcttcccatg cacgttgatc agggacgttg gtattcacta catttgtaaa gaaataataa 2825041 aaggcaatcg gcatgatcag agaccaaagc acaaagtact tgttcctaag cacccttttc 2825101 atttcagcga tgctttgctt ttgcagcacg ttcactcaca tcgcctccct gttgccgtca 2825161 gccagctggc gaaatgcctc atcgagcgtt gcttgctcaa ttcgaatatc ccgtgcatgt 2825221 atgttttctt gaaagatcag cgccaacact ttgtctgtat ttgatgtctg gatgatggtt 2825281 ctctcatgct cgtggatcac tctctcgact tccgggtgac aagacagcct ttccaatgat 2825341 tcacttgaat gaagcgtaaa ggaaacagac tgtttttgaa ttcttgagcg gatttgcatt 2825401 ggtgagccgt ctgcaacaag ctgtccttca gtaaaaaata ggattcgctg tgcggcatca 2825461 tctgcttcct gtaaataatg agttgaaaaa ataatcgttt ttccttggtc cgacagtccg 2825521 tgaatggtct gccagaatcg gtgtcttgat gaagtgtcca tgccgactgt cggttcatca 2825581 agtataagca gctccgggtt cccggcaaga gccaaagcaa agctcaaacg gcgtttttgt 2825641 ccgccggata atttttctgc tcttgttttc aaatcttctt tggtgagtgc tgttaacgaa 2825701 acgagttctt tcatggacaa tggattcgga taatagctcc ggaagagttc aaggatttca 2825761 tccaccttaa ggcccggcat gacacttact tcctgaagca ttacacctat tttttcacga 2825821 acctgttgat catcgggaac ccggttaaat agtttgattt ctccctcact cggtttcagc 2825881 aatcctaata tcatcgagac gacggtcgtc ttccctgccc catttggccc gagaatggct 2825941 gcaatttctc ctttttcaat actgaagctg atgttgttta cagcggtttt tcgctggaaa 2826001 tgttttgtca cgttgcttac tgttactgct tctttcatca catgagcacc tcctgatcgt 2826061 ttacattgat tgtaaaatga cggagaagac gatgttagta tggggtgtca tgatgatgga 2826121 gtgacaaatg tcattttttt ctcaccccgg tgtctaggca atcctcctcc tgcatcttcc 2826181 aattcatcca tcttttctat ctcccatgtc ctctttcttt taaactgctg tgacattcat 2826241 agaaagatac actcttcaaa ccatccgagt gttatgatag aaatattgaa ctttatatta 2826301 ctttccggct gaaaggagcc aatcatgaac gaagcgattt tgtctagaaa tcatgtgaag 2826361 gtgaaaggca gcggcaaagc atctatcatg ttcgcacctg gttttggatg cgatcaaagc 2826421 gtgtggaatg ccgtggcacc tgcctttgaa gaagatcatc gggtgatttt atttgattac 2826481 gtcggttcgg gacattcaga tttgcgcgca tatgacctga atcgttacca gacacttgac 2826541 ggctatgccc aggatgttct tgatgtttgt gaagctttag atctgaagga aaccgtgttt 2826601 gtgggtcact ccgtcggggc cttgattggg atgcttgcat ccatccgccg cccggagctt 2826661 ttttcccatc tggtgatggt ggggccttct ccttgctatt tgaatgatcc gcctgagtat 2826721 tacggaggat ttgaagagga gcagctcctt ggcttgctgg agatgatgga gaaaaattat 2826781 atcggctggg cgactgtatt tgcggcaacc gttctgaatc agccagatcg gcctgaaatt 2826841 aaggaagagc ttgaaagccg tttttgttct actgatcctg tcattgcccg ccaattcgcg 2826901 aaagcggcgt ttttttctga tcaccgagag gatctttcga aggtaacggt tccctctctt 2826961 attctccaat gtgcagatga tatcatcgca cctgcaacag taggtaagta tatgcatcag 2827021 catctgcctt atagcagtct gaaacaaatg gaggctcgcg gacattgccc tcatatgagc 2827081 catccagatg agacgataca gctgatcggc gattatttaa aagcacacgt gtgatatagg 2827141 aacgaaaggg atagaggtga ccctcttaga tggacaaaca attgaatgat gcaccatgcg 2827201 gtttcctcgc tttgtcagaa gaggggtcga tcatagctgc caaccgcacc cttatcaaga 2827261 ttctggatta tgaaccggag caggttatcg gccagcacat gaatatgatg ttgaccattc 2827321 ccgcgcagct tttctgccag ctttattttt ttccgctttt gaaattggag catcacatcg 2827381 aagaaatata catttccctg aaagcaagag atggagaaga aattcccgtc cttatcaatg 2827441 ctattgcgag acacgatagc ggggcttctg tctttgattg tgttctgatt ccaatgcgaa 2827501 agcgaaatga atatgaaaat gagctgctga tagccagaaa tgaggctcag gaagctttgc 2827561 ttgccaaaca gaaagccaat gcggagttag aaattgcctt ggaaacgctg aaagcaaaac 2827621 aagaagaact tcttgagatc aataaacaaa atcaacaatt taaattaaac accaaaagag 2827681 agcttgaact cgccagaaag atccagaaaa actcgttgac tgaaccgatt gtaaacgatc 2827741 aggttcagat tgactcttat tacaacgcat cgagtgaatt gtcaggtgat ctttacggat 2827801 attatcaaat cgatgaacac cgttacggca ttattatcct tgatgtgatg gggcacggaa 2827861 tttcatctgc attgattacg atgtctcttc atcctttgtt ccagcgccag atcacgcaag 2827921 gtctcagccc cgttaaagtt atgaaggaat tggaccggca ccttcacagc ttgtttcaaa 2827981 atgatgagga agcaagacat tattgcactg ctatttatct cgagattgat atagcacggc 2828041 aaagaattga ttatgtcaac gcagggcatc cgccggcact ttggcaggac gatagcggaa 2828101 ctcaacatct gcttcacgcg acctcgcctc cgatcgggat gtttgaagac ttagagtttc 2828161 agtcaagcag cctttcatac acggaggacg gaagattgct tctgtatacg gatggcgtga 2828221 tggatcctac ggcttcatgt tatttatttg atttactaaa ggatcatcct gattcgccaa 2828281 tcgctgacct gaaggagaaa atccttacat cactgcagca tcaaaaggaa gctcatcata 2828341 agagtgatga cgaatgtttt atattagttg atgtaaaata aaatgatcca tgagacataa 2828401 caatgatttg ttacatctca tggatttttt tgtttcagcg tttctttgga atatgtcctg 2828461 actccgcata ttgaaacacc tgcaaggaag gcagcgggtg tccattaaaa tcaaataaag 2828521 cttgattatc tacagcactt cccccatacc acttcccggc gtcttcaggg tcgtattcag 2828581 cagcatagct ggacgcccac cctgacccgt atgtttccca taacactttg tttttctcta 2828641 tctgtgtctt cggcccgact ggaatccacg ccggctccca gtagaaaaca ccaagtcctg 2828701 ctttgcccgt attcgccact gcctccatta catctcttac tgcagttgcc tggccttgaa 2828761 cagaaattgg atatggcaac gtctgcccgc tttttggtgc tgtatttcca tgcccatcgc 2828821 catcctcagc ggtataggtg tacgatgtct ccgccaccat gacttttttg ccgtacgtat 2828881 tggcaacagc cttcagcacg gaggtcaaat tttgtaatgt gccatgccag aaaggataat 2828941 aggagctagc aaacacatca taatccactt tgtttttgct gagtgtttct gcaataaatg 2829001 aataccttcc agccgtttca ggattggtaa aatgcagggc gaccaaaata tttgaatttg 2829061 tctccctgac cgctcggctt ccttcattaa ataattggca catcttcgtc caatcagtct 2829121 caccggcaaa tcctcctgtt gtttcatttc cgacctgaac catgccgatg tcaacgcctt 2829181 ccttgatcat cttttgcagg ctttgtttcg tatactcata gagctttgct ttttttgctt 2829241 caaagctgag attcgcccag gctttgggca ccttttgttt cgctggatcg gcccagaaat 2829301 cagagtagtg aaagtcggcc agcaccttca ttccgttcgc tgtcgctctt tttccgattt 2829361 cgatggcttt ttgaacatca ttgtttcccc cgccataccc gttgccattt gaatcatacg 2829421 ggtgattcca gatgcggacg cgaacatagt tgaccccagc ctgttttaaa gttgtaaaga 2829481 tatcctggcg ttttccgttt gtattgtaaa aggtgacacc gctgttttcc aaagcaataa 2829541 cgctggatac atctgcccct ttgataaaat ccttgttcat cccctctact tttttaacaa 2829601 aaagatcctc tgcccgaagc tctgacacgt gcttctcctt ctcaatggca gcggcatatc 2829661 ctgttgaact acatgcactc cacacgatgg cagccgcaaa gaacattttc actttgcttt 2829721 tcatgatttc atccccccaa gacttagcaa gcgttttcat tctatagaaa aaagaatccg 2829781 cccatatcga gcggagcatc agcctaatgt gtgtttacga caattctcac ttcatacttt 2829841 tccatcgtca ggtcgcctga caatatgtct cctgtcatta tgtccttcac actctgatca 2829901 aacgtgacca gctgtttttc ttccgtgaaa ttcatgacaa aaatataatc attgtcctga 2829961 tcctgcctcg cttgtacgga gacgcctttt ccgtgccgaa ccggaaaaac tggagagaga 2830021 gacaggtctg tgatcagacc ctcatagaaa tcacgctgaa attgatcctc caaacgcgcg 2830081 ccgataaaat acgccttgcc ctgctgatac tcatggcttg tgaccgctgg cgtgcgcgca 2830141 taaaaatctt cttgatacac cgcttccact gaagctgtct ttacatcaat cacggttgca 2830201 taatccttca tttcatatat ttggctgcgg tagctgacag cgtttcgatc cttcggatac 2830261 agggtgtccg tttcaagagg ctcaactcca aatatagctt gaagatccgg atgccatccg 2830321 cctgtgtatg ttaagtcatg ctcattcaca accccgctga tatacgtcat gactaaggtg 2830381 ccgccgtcag ccgtaaacgc ttttaaacgg gaaacggtgt cctcgctgat taaatacagc 2830441 atcgggacga tcagcagttt atatggtgaa aagtcttgtt ctttcgtgat gacgtcgaca 2830501 gggatatcgt gttcccagaa tgtgcggtaa tgctgctgaa gcgtttgcgg ataacgtttt 2830561 gtcgccttcg caaacccctg agcatcctcg agcgcccaat gattttccca gtcatataaa 2830621 atcgcggttt gagccggcct cttcgttccg acaacttcgg acagccgttc caatgtctcg 2830681 cctaccttgg ccacttcttg aaagacgcgg ttcttcgggc tattgtcatg atccacaacc 2830741 gctccgtgta atttttctga tgacccccgt gatttgcggt attggaaata gagaacgctg 2830801 tccgagccgt gggcaatcat ttgcatggat gacagcagat tcatgcccgg gcgctttgcc 2830861 ttgttgacgt tatgccaatt gaccgcgctt ggcgtacact ccattaataa gaagggctgc 2830921 tgcttcaagc ttcggtacag atcattgata aagccgacct tcatcgccaa atcagctgtg 2830981 ctttcccagt cattgtgcca gacaggataa gcgtcccagc tgatggcatc gacatgcttt 2831041 gcaaatttgc tgtagtcgag gccctgatac gggatcaaat ccggtgtgtc agccataaaa 2831101 ttcgttgtga tagggatatc aggcgtcaat tctttcagcg gaatgatttc attttcataa 2831161 aacgaaatcg tttgatcggt gacgaaccgg cgccaatcta aattcaggcc atgcaagcca 2831221 ttttcaccga tcggcgaagg gctttcaatt tgtgaccagt cattgaacgt atggctccaa 2831281 aaaggggtcc accacgcatg gttcaatgtc ttgaggctgt tgtcatattt cgatttcagc 2831341 cactcccgga aagcatgctg gcataaatca cagtggcaat ctcccccgta ttcgtttgaa 2831401 atgtgccaca ttaacagcgc cgggtgatgt ccgtatcgtt ctgctaataa gcggttgatg 2831461 tgccgtgttt tttctcggta gactttagat gtgaggcagt ggttgtgcct tccgccgtgc 2831521 agctgtttga cgcgggaggc attgacgcgc aaaacttccg gataggtttg cgacagccag 2831581 gccggacggg ctccgctcgg cgttgctaat atgacccggc cgcctatact gtgaatccgc 2831641 tcaaaaatat catccagcca ttcaaattga tatacgccct cctccggctc aagtgcgctc 2831701 catgcaaaaa tgccgacaga aaacgtattc gtatgagaaa gcttcatcag tttgatatcg 2831761 tcagctaaaa tatcgggccg atccagccac tgatcggggt tgtagtctcc cccatggagc 2831821 ataaattttg cttttgttac gtgcgttttt tcaagctttg acatcacatt ctcctccttg 2831881 ttctcttagc ccttcgttcc gcctgcggtt aatccggaca caaaattctt ttgcagcata 2831941 ataaagatga cggcaaccgg tatgctgata agcagggctc cggccgcaaa tgtcgtatag 2832001 ctggccccca tgacatcatt cactaaattg aatagaccga cgggcaatgt atatgattca 2832061 ggcgttctca atatggttga ggacagcaca aaatctccga gcggaccggt aaagccgttc 2832121 atggccacga ctgccgccat cggttttgat aatggcagaa tgatctggaa gaagattctg 2832181 gtgctgctgg ctccgtcaat cttggcgctt tcgtctaaat ccatcggaat ggaatccatg 2832241 taccctttca tcaaatacgt attcatcggg atcaggccgc cgatataaag caagattagc 2832301 agccagtggc tattgatcat tcccaagatt tgcgccagca caaacaaggc aattaaagct 2832361 gaaaactgag gaatcatctg cagcaataaa aagagcgtta aagcgtattt cctcccttta 2832421 aaccgaaagc gcgaaaacgc ataggccgta aacgtcacac agagcaaaga ccctgccatt 2832481 gtaaacaggc tgatcttcat agagttgaca taccactgca catattgaag gctttccttg 2832541 cccgcaaata attccttgta atgatcgaat gtcggatgct tcggaatgat ggatgtactg 2832601 attaagctgt tgccgggatt aaagcttgcg cctgccgtcc aaaggagagg ataaacaatg 2832661 atgaccgcca taaaggctag caacaagtaa gagaaaagga gacggatata tcttctgact 2832721 ttcatatctg ccagcatacc ttatgcctcc tctttaaaag actttgtctg tctgaactgc 2832781 cacaatgcga tggagataac aaatacagat aataaaatgg ttaaagccgc agcaagtgaa 2832841 tattggctgg actgcattgt caatttataa atccatgaaa cgaggatatc tgtcccgccg 2832901 gctgttgatc cggttacagc cggacctccg ccattgaata gatagataat attaaagtta 2832961 ttaaagttaa acgtaaactg agtaatgata atcggagcca ttgcaatgaa caccatcgga 2833021 agcgtgatgt atctcagctt tgaaaagaca gaagcgccat caatcgtagc tgcttcatac 2833081 agatcgtccg ggatggattg caatacgcct gttgagacga gaaagatgta cggaaatccg 2833141 agccagccct gcatgagaat caatgcaagc ctcgaccaat tggcatctgt catccacgga 2833201 agcggatcta tcccgaagaa agccaagatg tcgtgattca tcgcaccgaa gctatcatta 2833261 aacagtcccg caaaaattaa aatcgtcaca aaaccgggaa cggcccatgg caaaatcaga 2833321 atcgtccgaa aaaaacgttt aaaccgaagg tctttctggt taacaatgat cgcgagaaaa 2833381 atccccaagg tgacttgcag tgtggatgca gcaagtgtcc aaaccaccgt ccaagccagt 2833441 acatcaaaaa aagtcgacct ccaaatatca actgtgaaaa tatttgcgaa cgtttgaaaa 2833501 ccgacccaat caattaattt tgcaggagga gaatgataca aatcatagtt tgtaaacgct 2833561 aatgcaaagc tgaataagat aggaaagatc acggcgaaaa ttaaaataaa caaagatggg 2833621 ccgctgacga cataaggata gccctcagaa atgatatgct ggtattgttc ctttaaggaa 2833681 cttaatggct tattttcatc acgctgtttt ccgctttgga acgcatcgcg aagatttaca 2833741 taatacaccg caaggccaaa gcaggtcacg atgacagcaa taatcccttc cgccagcaga 2833801 aaaacggaat tatcccgcgg cacttctgtt cccagtgtaa agattcccca aaaccccata 2833861 ttgagcagat ctccaaagac cgcaaaaaac gatgcgccta agaaaagaaa gacaatacct 2833921 tttatccatt gcttgttata aaattgcccg agtcccggaa tgatagaaag caacaaagcg 2833981 acttgacgat gctgcaccgt tttcacctct cttacaatac aaatctagct ttctctttat 2834041 tttccgctgt gctttgcctt aatttgtcct ttggccgttt cagctgcttg atccaatgct 2834101 tgtttcggat ctgccttccc tgttgcaacc gtctgtaatg ctgaatcagc cggcgtccat 2834161 atttcattca tttccggaat atttggtgtt ggctctgaga aacgggattg ttcagtaaca 2834221 gcccgtgccg cctcgctttt cataatagcc gggtcattgg ctagggattt cacagcagga 2834281 acttctttcg tttcttcata tcgtgtttta gaattttttt catttgccag gaaaacggct 2834341 aattcttgcg ccagctcttc attctttgaa aatgcactga cgttgtagct tttgacgccg 2834401 ataaaggagc tcatgttttt cccattttcc agcttcggca gtttcgtaat gccataattg 2834461 attcctgcat tcgaaaaggc ttctacattc catggaccag aaataattgc ggcggctttt 2834521 ccttctgtga acagcgattc caacacgtta atcccttgtt ctccaataat gccagccggg 2834581 aacaggccat ctttgtaaaa cttctgaatc agcgccgcac ctttgacagc tccttcatta 2834641 ttgattccaa tgtctgacgg gttatagctc ccatctttgg cctttccaaa aatgtatccg 2834701 ccatatccgc tcatcacact ttctgcataa taaatttgat cgaatagggc taaaaagcca 2834761 aatttgctgc cgtcagcagt ctttttggaa tagtcgtacc actcttccag cgttttgggc 2834821 aattcctttt ctgtgatgag atctttgttg taaaaaagca cagtcgtttc gaccgctttt 2834881 ggcagtccat aaagcttttg atctaccatt tgagactgaa tggaagcgtc agtataaagt 2834941 gattgaacgt cttttttgac atgtaattcc ttgagtaatc cttccgtgac agcggttccg 2835001 atttggtccc ctggcattgt taacacgtca gggcctgtgc cggccggtcc atccattcgc 2835061 aaatcttcaa tctgcttggc atacggtttt tcaacgactt tgaccttcac atcatgctct 2835121 ttttcaaatg cagccacagc gtctttaatg ccgttgctct tttctttatc ctcccataca 2835181 acaagctctg acccttttga actcgatttg gcgctgctgc tttcctttgg gccgcaagcc 2835241 gccaaggata aactgacagc tgcgcagagc atgaatacgg aacacttttt tgccattttc 2835301 attgattgtc accctttcgg taggaatgaa agcgctttaa agataatata gcatgcctga 2835361 gaaaatgtgt aaacaaacta tttacttcat agagtaaatt tttttaccta aataaaaaat 2835421 gacttagtgt cctaagtcat ccttaattca tactcttcct gacgattaat tctgcgccca 2835481 catataatgt ttttaccgtt cttctcttgt cctgcacttg ttcaagcagt aattgaacag 2835541 cgtttttaca taattcatgt atatcaatat gaaacgtcgt cagaggaggc gagacatact 2835601 tcgcgaagct gatgttgttg atactcacaa tgcttaccct gtttggtatg gcaattcctt 2835661 tttcgttcag ggcttgcaga cagcccactg caatcgggtc cgctgcaatc ataaaagcag 2835721 tcggaagctg atcgcctaat gtgtcgatcg ctgctgacat caggcggtag ccgttttcta 2835781 cagagaatcc gcgatgacag aaaatatagc gctcgtccag catggctttt tccctcatat 2835841 aggatctgaa ggtttgttca cggatgtcca tttcatcctg attggtattc ggatttttgt 2835901 atgtgccgcc gataaaaccg atgctcttat gccccttctc agtcaggatg tttaccgtct 2835961 tccttgtcat ttgtgccaaa tcgggcctta ccgagtcaaa atgatcggga tcaggagttg 2836021 aatcgatgaa cacgccgttt tcagtgagat ttctgaggaa agccagctct tcatctgaaa 2836081 atgtgccgac ggcaataaac ccttccgtat gttcaggaat gctctcgatt ccatccgcta 2836141 ttttataagt ggtcatatcg acattgaatg ctttcgccag tttctctact tctaatctca 2836201 tcgttttaaa atagacatct tctaattctt ctttatctgt cagccaatat aaaaacgcaa 2836261 tatgtttcac cagcggcctt actgtttttt tgcggtaatt gagcttttcc gccgcttcat 2836321 agattttctc ccgtgtctca tcaggaacag aaaggctttc atcgttattt aaaacgcggg 2836381 aaacggttga gattgaaaat cccgcttcct gcgcgatatc tttaattgtc gccattgtat 2836441 ctgcctccat tattcagctc gcattgtttt agtaaaatat tttactttct ttttcacaaa 2836501 tgtcaagtgc acaaagccct ctggctgcca tgtaaaaaga ctgaaccatt tgcggctcag 2836561 tctcagttgt tcgtatcatt cggaaccggc ggaattgccc gggaaatgag ttggttattg 2836621 cacattttcc tcgaaatatc ccgaaagcac atcttccaca ttcgtcaaat gcgccagcat 2836681 ggcggcttcc gcctgtgcac cgttcccggc agccacagca ttgtaaatcc gttcgtgctc 2836741 ctcatacagc cgctgaacgg aggtcttctt ggaaaacagc cagattttcc tcgtttccct 2836801 cattgtttcc agcagcaatg atgacacgtg attcatcaag tgtttaagaa gttcattttg 2836861 agaagcgtcc gcaagcgcaa gatgaaatgc aaagtctgct ttctctccca gctccccgtc 2836921 cgcttcaatg ctgcccattt cctttagtgc atcctgaatt ctttcgagat ctgcttctgt 2836981 ccttttttca gccgctagtg aagccacgcc gatttcaagc agttttctga cctcgagcag 2837041 ctgcttgacg tcctcttttt tcatcagaag ggcggctgag agcggctgag aaatttgatt 2837101 gagctcaaat tccttcagat acgtgccttc tccctgtttc atttcgacaa gccccatcgc 2837161 ttttagcgca gaaagtgctt cgcgaaccgc tgaacggctg acttgaaagc tctcagcaag 2837221 cgcctgaaca gagtccagtt tatcccccgg cttcaattcg ccatttttga tcatatctaa 2837281 tagggcatcc gctacttctt catatatttt tttgttttaa tctgtttata tttcaatgca 2837341 attcaccccg taacttgtag gtctggctgt ttacgatcta ttatactctg ttttgtgggc 2837401 cgccaaaaga ttttgactat tttgtcaaaa agtcttgtac tttgattttt ttcaaaatat 2837461 aatgctaggt aactggtctt attacccagt catcagatga tcatatcatc tatagaaacc 2837521 gcttacatat ggcgccagtt tatgtttcaa ggaggggttt gggatgcaat ggacacaggc 2837581 atatacgcct atagggggaa atttgctatt atcagcgctt gccgcacttg taccgattat 2837641 tttctttttt tgggcactcg cgattaaacg gatgaagggg tatacagcag gcttggccac 2837701 attggggatc gcccttatca ttgctgtatt ggtttatcgt atgccggcgg aaaaagcgct 2837761 gatgtccgcg acacaaggag ccgtatacgg attgttgccg atcggctgga tcattgtgac 2837821 gtctgttttt ttgtataaaa tcactgtgaa aacgggacag tttgatatca ttcgcagctc 2837881 tgttctctcg attactgatg accgacggct tcaagctctc ttgatcgctt tttcattcgg 2837941 ggctttttta gaaggggcag caggcttcgg agcgccggtc gccatttctg ccgcgctgct 2838001 ggtcggtctc ggctttaatc ctctttatgc tgcggggatc tgtttgatcg ccaatacggc 2838061 gccggttgcc tttggggcaa ttgggattcc aattacagcc gtagaagggc cgacagggat 2838121 tccggcgatg gagatttcgc aaatggttgg gcggcagctg ccgtttttat ccgtatttat 2838181 tcctctttat ttaatcatca tcatgagcgg gttcaggaaa gccttggaga tctggccggc 2838241 gattctcgta tccggtgttt cctttgctgt tgttcaatat ctcagttcca attttttagg 2838301 gcctgagctg cccgatgttt tgtcagctct tgtttcaatg gctgcgcttg ctgtgttttt 2838361 gaaatggtgg aagccgaaaa caacattccg gtttgccggt gaacaagagt cggccgcctc 2838421 aattgaaacg gcgcgcacaa atccggcggc gcctgcatac agaggcggac agatttttaa 2838481 ggcttggtcg ccatttctgc tgctgacggc gatgatttcc gtatggggca ttccatctgt 2838541 caaatccgcg ctgaccgggc attatgaagg ctctgcggtg ttcttgaagt ggctgaatgc 2838601 tgttggagaa aaactgactt tttcccccgg tgtgcctttt ttgaacaatc agattgtcaa 2838661 tgctgacggt acgccgattg aagcggttta caagttggag gtgcttggtt cggccggcac 2838721 cgcgatattg attgccgcag tgctgtcaaa attcatcacg gcgatttcgt ggaaagactg 2838781 gggaaccgtt tttaaagaaa cagtccagga attgaagctt ccgattttga ccattgcttc 2838841 tgtcgttggt tttgcctatg tcaccaactc ctcgggaatg agcacgacac tcgggatgac 2838901 actcgcgctg acaggttcga tgtttacctt cttttcgccc gttctcggct ggctcggcgt 2838961 cttcattacc ggctcggata cttctgccaa cctgctgttc ggcaacctgc agaaagtcac 2839021 cgcattatca gtcggcatgg accccgttct gtctgtggcc gccaactctt caggcggtgt 2839081 cacaggaaaa atgatttcac cgcagtcgat agcggtggcg tgcgccgcgg taggactcgc 2839141 cggaaaggag tcagatcttt tccgctttac cattaaacac agtctgtttt tgctgctgct 2839201 cgtctgtatc atcacctttt tgcagcatca cgtattcagc tggatgattc cttaaaaaaa 2839261 tcctcccgtc tagggaggat tttatttata tcgctttctc gctgccgatg acggaatatt 2839321 catttgatcg cgatattttg ccacggtgcg tctcgagatt tggatgccgt gttgttcata 2839381 cagcaaatcg acaagctttt ggtctgaaag cggttttgtt ttgtcctctt gattgatcag 2839441 gttttccaga tgcgttttga ctgcataatt cgacgcatct ccatcacctg aagcctcggc 2839501 ttttgctgag aaaaagagtt tcatctcaaa cagcccgtaa ggcgtttgta ttgttttccc 2839561 tttaatggcc cggctcacag ttgattcatg aaggcttaga cagtctgcca cctctctgag 2839621 agtcagcggc ttcattgcgc ttcgcccttt cagaaagaaa tccttttggc gtgtgatcag 2839681 ttcattgata attctcgtga ttgtctgttt tcgctgccgc agcgcgcggc tcagccagcg 2839741 ccactcctga tatttcgcag ataaatagga gacagtatcc tgacaggagc cggatgataa 2839801 aagcgttctg tactgcggat gcagatcgat ctcgggaaac gagcgggtat tcagttccgc 2839861 tgcgatgtgc ccatttttta cggtgataaa aatgtcaggc tcaatataca catcttgctc 2839921 tggccgggca aacagaaggc caggtctagg atgaagagcc gcgatatcat ctgagatatc 2839981 ttgaatggta tgaagcggaa ttcccgtctc tactgaaagc gttttccatt ttttttgcgc 2840041 aaaagcatca aaatgagctg aaaccagcat ttccgcttgt tcatttctgt tcggcagccg 2840101 ctgtaattga agaaggatgc attcctgcaa agatctcgcg ccgattccag ccggttctaa 2840161 cgactggagt tttgccaaaa cagcctccgc ttccttggcc gatacagata atcgccgtgc 2840221 tgcctcctct atatcttctt ccaagtaccc gtttgaatca agcgaatgaa tcagataatt 2840281 aaaaatcttt ttttcagtgt ttgtcagatt catatcgagt gactgctgtt ttaacgcatc 2840341 ctgcaatgtt ttttgcggat tacttaattg aaggcccgct tcctgtgcat tcatcctgtt 2840401 tttgtttgtt ttatggtaag atagtggcgg tgtgtctgtt tcctttcgtt caataagagg 2840461 gttttccagt gagagctcat caatgtactc ggcgagttct gccgaatgat agccaagcag 2840521 cgtgatggcc tgcctgagct cctgtgtcag ttgaggcttt aatacttgta cttgctgaag 2840581 tttcatatcc atcttgctca ctcccctttc ttcattgtac atgattgaga tcacaccgta 2840641 tacatttatg aaaaaggagc tgccaaagaa atgtctgaac ttttttccgt cccttatttt 2840701 attgagaatt taaaacagca tattgaaatg aatcagtctg aggataaaat ccacgcgatg 2840761 aacagctact accgttccgt cgtctcaaca ctagtgcagg accagctgac gaaaaacgca 2840821 gttgtcctga aacggattca gcatttagat gaagcataca acaaagtcaa acgtggagaa 2840881 tcaaaataaa ccttccgaat tcgggaagat gatgatcggt taaagggcta acgttcgcat 2840941 ctatagggga aatctgttta taatggggga aaaagggaga gaacacaatg actcatcaaa 2841001 tagtaacgac tcaatacggc aaagtaaaag gcacaacgga aaacggcgta cataagtgga 2841061 aaggcatccc ctatgccaag ccgcctgtcg gacaatggcg ttttaaagca cctgagccgc 2841121 ctgaagtgtg ggaagatgtg cttgatgcca cagcgtacgg ctctatttgc ccgcagccgt 2841181 ctgatttgct gtcactttcg tatactgagc tgccccgcca gtccgaggat tgcttgtatg 2841241 tcaatgtatt tgcgcctgac accccaagta aaaatcttcc tgtcatggtg tggattcacg 2841301 gaggcgcttt ttatctagga gcgggcagtg agccattgta tgacggatca aaacttgcgg 2841361 cacagggaga agtcattgtc gttacattga actatcggct ggggccgttt ggctttttgc 2841421 acttgtcttc atttaatgag gcgtattctg ataaccttgg gcttttagac caagccgccg 2841481 cgctgaaatg ggtgcgagag aatatttcag cgtttggcgg tgatcccgat aacgtaacag 2841541 tatttggaga atccgccggc gggatgagca ttgccgcgct gcttgctatg cctgcggcaa 2841601 aaggcctgtt ccagaaagca atcatggaaa gcggcgcttc tcgaacgatg acgaaagaac 2841661 aagcggcgag cacctcggca gcctttttac aggtccttgg gattaacgag ggccaactgg 2841721 ataaattgca tacggtttct gcggaagatt tgctaaaagc ggctgatcag cttcggattg 2841781 cagaaaaaga aaatatcttt cagctgttct tccagcccgc ccttgatccg aaaacgctgc 2841841 ctgaagaacc agaaaaagcg atcgcagaag gggctgcttc cggtattccg ctattaattg 2841901 gaacaacccg tgatgaagga tatttatttt tcaccccgga ttcagacgtt cattctcagg 2841961 aaacgcttga tgcagcgctc gagtatttac tagggaagcc gctggcagag aaagttgccg 2842021 atttgtatcc gcgttctctg gaaagccaaa ttcatatgat gactgattta ttattttggc 2842081 gccctgccgt cgcctatgca tccgcacagt ctcattacgc ccctgtctgg atgtacaggt 2842141 tcgattggca cccgaagaag ccgccgtaca ataaagcgtt tcacgcatta gagcttcctt 2842201 ttgtctttgg aaatctggac ggattggaac gaatggcaaa agcggagatt acggatgagg 2842261 tgaaacagct ttctcacacg atacaatcag cgtggatcac gttcgccaaa acaggaaacc 2842321 caagcaccga agctgtgaat tggcctgcgt atcatgaaga aacgagagag acgctgattt 2842381 tagactcaga gattacgatc gaaaacgatc ccgaatctga aaaaaggcag aagctattcc 2842441 cttcaaaagg agaataaata tggggaaaac aggatacatt ggtgctgcca ttgttgtggc 2842501 agcttgtatc attattttgt cggccgtggt atgtttacgg gacacagtct attaccagcc 2842561 tatgcgctgg actggcatca tactgttttt cgcgggaatt gtgatggttc ccgcatactc 2842621 agcaaaaaga aaacccggaa aagagaagta attctctttt ccgggttttt atgtttatta 2842681 taatcttccc gcgcgaatat cgtctgtcat tccctcataa ggagccttcg aaatcacttc 2842741 ttcgttgtcg actccttcat ttttcagaaa tgtaatttcc gcaaattcag gtacaacgta 2842801 ttttggatac gtttcatatt tttcgcggga ttctttcatc aaatcaatgt ggtcattttg 2842861 gtagcaaacc gtaatttcag gatgttcatg cacccatttc gggaagaaaa taatgccatg 2842921 catgcgtttt tcatttggca taaagtttaa tgaaacatcc gtgccagtcg gctctgtcca 2842981 agacacttta tatacgcctt ctgtcagttt gacaatattc acttcctgat ctcgaaccca 2843041 gcgtccggca accattccgc tatgaattct ataatcaatt gtatggtcgt ttttaatata 2843101 aatctcgtat tcccatccgt tttcatacgt ataaatcatg tggcttccga taaagttttc 2843161 catcttacac actctcctta gtcttttact gtacttcata aatgtctagt agaacgtaat 2843221 caggggttct ttctgcggaa ccgataaaca agcggtcatg gagccattga tagacttcac 2843281 tgcctgtttc aaacgtcggt accgtacgaa aataaacatg ctccggttca ataatttccc 2843341 cggctgccgc ttgttttcga aacggcttgc tgacttgccg tattccattg ttttcaatgt 2843401 aaatcagttc atgatctgct gtttcaatca catacctggc agataaatct gttctgccgt 2843461 tagcgcgaat catttgtgaa tcggcaccgc ccggcaaaat acgtcccttt acttccccgg 2843521 ttattgttcc cgaacgaatc ggaatgaatc atctcagtcc caggcttgtc tcaccaatcg 2843581 tgataggcgg atcaaccttg atttctaaag aggcgaatgg ttttaaaacc ggcttcttca 2843641 cgagaaccac ctcaccttca gaaaaaatca tgtaactatt tacatgttca ctttaacacc 2843701 attgcagtta actgtcaaac aataggaaca taaaaaaaca aggactgttt gaagacagtc 2843761 cttgtctgaa gctagctttg ataagcaaga tatgtgctga cagtgctttt ggcaagacag 2843821 gcagaggaat ctataatcgg aatctcactt tgaatatgat ctaacaccgc atttaaatcc 2843881 gtgcaggctg aaatgatgat gtctgcatgc tgactgattt cttcatatag cgtctgccac 2843941 aatgcttgtg tatgctgcat atgatttggc tgtttgattg cggcgataag ctggttcaca 2844001 gcctgctgcc aatggtcctt gtgaataact tcttgtccat ttcccttcag aactttttgg 2844061 tagatggcgg attggatggt tggctctgtt cctaaaacca ccgctttttt tgcgggatgc 2844121 ggaatctctt ttatcgtttc ctcaacaata tgcaacatag gaactgacaa tgcctgctga 2844181 atctcttcat agtagacatg cgccgtatta caaggcagcg caatgaaatc cacgcctgtt 2844241 ttctcgagct ttaccgctcc gtcgataatc gcttttttca tctcgtcatg gtcaattgga 2844301 cgatctgcat agaagggcgt cgggcatgaa tagatcatca tgtgcggata gtcaatatcg 2844361 tttgaagccc catacagctt ctgacagtaa tcaatcacct tatcaataaa cggcgaggtc 2844421 gatttcggcc ccattccggc taatattccg atcatcaaat tcattccttt ctacttcgta 2844481 cggaccgctt cttcctctga gccatcctca tagaggataa agcttttcgc agcatcctca 2844541 cctaatgtaa actcgacttc aacagacaat gctcgcagaa agaaacgggt ttccgaggaa 2844601 ggaaataact ccagtctcag ctgtccggcg atctccaaat aaagccgttc attctcggtt 2844661 gtcacctgtg cagccgtccc atcctgcaac aggtagctgc caacatagcg gctgtatatc 2844721 gccgtatcaa ttgctttttt ctttttatca gcaggacgtt ccgggacatc atatggctgg 2844781 ccaaatagaa tatgttccgc cgccttcaga atcgcttgtt catattcagt atcctcttcc 2844841 ttattactca aatagatcag cgttttacga tgatcgatat atcggatcat catcgtcgaa 2844901 tagccgggcc atcctccgct gtggctgaca atccgccctt tttcaggact gttttgcagc 2844961 acccagccaa agccataatc aattgtttct ccattgttga ggcgcactgg agaaaacgca 2845021 gattccttag aagccttgct gatgaaatcg tcctgatata aagcctgatc aaatcgaaac 2845081 aaatcgcttg tgacagagtt aaccgtccca tctccctgta tgccatcgag atacacaaca 2845141 tagttcgttt cctccagctc atcagggagg acgtatgttt cggaatgtac atcatacaca 2845201 tatccatatg cataatgatc aattcgctca ggcgaaagcc tcctgttata cactcttgtt 2845261 tcattcatgc ctgccggtaa aaaaatactt gtttttataa aatccgcata gctcatgcca 2845321 gatgcttttt caatgataac cgccagcagc acataccccg tattgctgta catccagcct 2845381 tcattcggtt caaaataacc agatagcccc tcattcatca gcatatcgac aatatcctga 2845441 ttcaccgcaa tcttgtgtga atcccaattg gcaaaaaacc atcccatata atcaggaagc 2845501 cctgacgtat ggttcaataa atgccgaatc gttacgccct gatacggaaa accgggcagc 2845561 cagcgatcca ctttatcctc atagccaaga atccccttct cctccagcaa gatgattccc 2845621 aatgctgtaa aaggctttga caaagacgct aactcaaaca aagagttggt tttcaacggg 2845681 cgtttttccg tcatttccgc atagccaaaa gagtggtgat ataaaatatc gccaccctcc 2845741 gcagccagaa ccgtcccgtt aaactgatgt ttttcgccta atgtctcaaa taacgtctga 2845801 agatgctttc ttttattctg cttcattcct ccacctccca tatctctgta cgttactaac 2845861 ctactaacgt ttcaaatatt ttgaaaaatc cttcagttag agatcctttt taacccatca 2845921 catatacctg ccgttcacta ttatttagtg aaatgagata ttatgatatt ttctgaattg 2845981 tgattaaaaa ggcaacttta tgcccatgca acagaaacta taaaaaatac agagaatgaa 2846041 aagaaacaga tagatttttt agttctttag gcccgtagtc tgcaaatcct tttatgattt 2846101 tctatcaaac aaaagaggaa aatagaccag ttgcaatcca aacgagagtc taatagaatg 2846161 aggtcgaaaa gtaaatcgcg cgggtttgtt actgataaag caggcaagac ctaaaatgtg 2846221 taaagggcaa agtgtatact ttggcgtcac cccttacata ttttaggtct ttttttattg 2846281 tgcgtaacta acttgccatc ttcaaacagg agggctggaa gaagcagacc gctaacacag 2846341 tacataaaaa aggagacatg aacgatgaac atcaaaaagt ttgcaaaaca agcaacagta 2846401 ttaaccttta ctaccgcact gctggcagga ggcgcaactc aagcgtttgc gaaagaaacg 2846461 aaccaaaagc catataagga aacatacggc atttcccata ttacacgcca tgatatgctg 2846521 caaatccctg aacagcaaaa aaatgaaaaa tatcaagttc ctgaattcga ttcgtccaca 2846581 attaaaaata tctcttctgc aaaaggcctg gacgtttggg acagctggcc attacaaaac 2846641 gctgacggca ctgtcgcaaa ctatcacggc taccacatcg tctttgcatt agccggagat 2846701 cctaaaaatg cggatgacac atcgatttac atgttctatc aaaaagtcgg cgaaacttct 2846761 attgacagct ggaaaaacgc tggccgcgtc tttaaagaca gcgacaaatt cgatgcaaat 2846821 gattctatcc taaaagacca aacacaagaa tggtcaggtt cagccacatt tacatctgac 2846881 ggaaaaatcc gtttattcta cactgatttc tccggtaaac attacggcaa acaaacactg 2846941 acaactgcac aagttaacgt atcagcatca gacagctctt tgaacatcaa cggtgtagag 2847001 gattataaat caatctttga cggtgacgga aaaacgtatc aaaatgtaca gcagttcatc 2847061 gatgaaggca actacagctc aggcgacaac catacgctga gagatcctca ctacgtagaa 2847121 gataaaggcc acaaatactt agtatttgaa gcaaacactg gaactgaaga tggctaccaa 2847181 ggcgaagaat ctttatttaa caaagcatac tatggcaaaa gcacatcatt cttccgtcaa 2847241 gaaagtcaaa aacttctgca aagcgataaa aaacgcacgg ctgagttagc aaacggcgct 2847301 ctcggtatga ttgagctaaa cgatgattac acactgaaaa aagtgatgaa accgctgatt 2847361 gcatctaaca cagtaacaga tgaaattgaa cgcgcgaacg tctttaaaat gaacggcaaa 2847421 tggtacctgt tcactgactc ccgcggatca aaaatgacga ttgacggcat tacgtctaac 2847481 gatatttaca tgcttggtta tgtttctaat tctttaactg gcccatacaa gccgctgaac 2847541 aaaactggcc ttgtgttaaa aatggatctt gatcctaacg atgtaacctt tacttactca 2847601 cacttcgctg tacctcaagc gaaaggaaac aatgtcgtga ttacaagcta tatgacaaac 2847661 agaggattct acgcagacaa acaatcaacg tttgcgccaa gcttcctgct gaacatcaaa 2847721 ggcaagaaaa catctgttgt caaagacagc atccttgaac aaggacaatt aacagttaac 2847781 aaataaaaac gcaaaagaaa atgccgatat cctattggca ttttctttta tttcttatca 2847841 acataaaggt gaatcccata tgaactatat aaaagcaggc aaatggctaa ccgtattcct 2847901 aaccttttta ggaatattgc tgtttatcga cttatttcca aaagaagaac atgaccaaaa 2847961 aacaaaatca aaacagaagc cggactaccg ggcggcatat cattttacga cgccggataa 2848021 atggaaaaat gaccctcaaa aaccgatcta ttttgatggc aagtatcatt atttctatct 2848081 atataaccgg gattacccaa aaggcaacgg cacagaatgg cgccatgccg tctcagagga 2848141 tttggtgcac tggaccgatg aaggcgtggc gattccgaaa tatacaaacc cggacggtga 2848201 tatttggacc ggttccgtcg tggtggataa agagaacaca gccggcttcg ggaaaaatgc 2848261 gcttgtcgcg attgtgacac agccctcagc caaagacaaa aaacaggaac aatatttgtg 2848321 gtacagcaca gataagggaa aatcattcaa attctacagt ggcaaccccg ttatgcctaa 2848381 tccgggcaca gacgatttca gagatccgaa agtcatatgg gatgaccaag ataacaaatg 2848441 ggtcatggtc atggctgaag gatcaaaaat cggcttttat gaatccgata atcttaagga 2848501 ctggcattac acaagcggat tcttcccaga acaggcggga atggtggaat gtcccgacct 2848561 ctacatgatg cgggcaagcg acggaacgaa taagtgggtt ctcggtgcca gcgcgaatgg 2848621 caaaccgtgg ggcaaaccaa atacgtacgc ctactggacc ggaagcttcg acggaaaaga 2848681 attcaaagcg gatcagactg aagcccaatg gcttgactat ggcttcgact ggtatggcgg 2848741 tgtgacgttc gaagacagca aaagcacaga tccattagaa aagcggtatg cgcttgcctg 2848801 gatgaacaat tgggattatg ccaacaacac cccgacaatg aagaacggct ttaacggcac 2848861 agattctgtc atacgcgaac tccggctgaa ggagcaggat ggaacataca gcctcgtctc 2848921 acagccgatt gaagctttgg agcagctgac tgtttcaact gacgaaatag aggatcagga 2848981 tgtgaacgga tcaaaaacat tgtcgataac aggtgatacg taccagcttg atacggatct 2849041 ttcttggtca gagctaaaga atgcaggcgt caggctcaga gaatcagaag accaaaaacg 2849101 ccatattgat gtcggcattt tcgctgaagg cggctatgct tatgtcaata gagcagccac 2849161 aaatcagcct gacaaaagca atacctatgt cgaaagcaaa gctccttatg atgtaaacaa 2849221 acgtaaggtg catttgaaaa tacttgtcga taaaacaacg atagaagtat ttgttggcga 2849281 cgggaaaacc gttttttcaa atgaagtctt cccaaagcct gaagataaag gaattaccct 2849341 ttattctgac ggcggcacag cctccttcaa aaatataaca gtgaaacact ttgattcgat 2849401 tcatgaataa aaacaggggc ggcgcaggct gcccctgttt ttttattagg agcggtattc 2849461 tctgttacat attgggcatt gtaaggaata taaggctggt ttcaaaggag gaagcgaatg 2849521 tctaaacaag gaaattttca aaaatcaatg tcgctgtttg atctgatttt gattgggatg 2849581 ggagccatct ttggatcagc gtggctgttc gctgtcagta atgtcgcttc aaaagcaggg 2849641 ccctccggcg ctttttcctg gatcctcgga ggagccatta ttttgttaat cgggcttgta 2849701 tatgcggagc tcggagccgc tctgccccgt accggaggca tcattcgata ccccgtttat 2849761 tcacatggcc accttgtcgg ctacttaatt tcgtttgtca cgattgtcgc ttatacaagc 2849821 ttgatttcaa ttgaagtgac agctgtgcgc cagtatgtgg cctattggtt tcccggcctg 2849881 accattaaag ggtctgattc gcctaccatt tccggctgga tcttgcagtt tgccctatta 2849941 tgcttgtttt tcctgctgaa ttattggagc gtcaaaacct tcgctaaggc gaatttcatc 2850001 atatcgattt ttaaatatat tgtgccgatt accatcatta ttgtgctgat ctttcatttt 2850061 cagccggaga atttatccgt tcaaggattt gcaccgtttg gatttacagg tattcaggct 2850121 gccatctcga caggcggcgt catgtttgcg tatctcggcc tgcatccgat tgtatctgta 2850181 gcaggtgaag tccaaaatcc aaaacgcaat atcccgatcg ctttaatcat ttgcatcatc 2850241 gtttcaacca tcatttatac tgttttgcag gtcaccttta ttggtgcaat cccgacagaa 2850301 acactgaaac atggctggcc ggcaattggc cgggagttct cattgccgtt taaggatatt 2850361 gcggtcatgc tcgggttagg ctggcttgca acgcttgtca ttttagacgc cattctgtct 2850421 cccggaggaa acgggaatat ctttatgaat acgacatccc gccttgttta cgcctgggcg 2850481 cgtaacggca cattatttgg catattctca aaggtcaata aagatacggg gacaccccgc 2850541 gcttcgcttt ggctttcgtt tgccctgtcc attttctgga cacttccctt tccttcgtgg 2850601 aacgcgctcg tcaatgtctg ttcagtcgcg ctcattcttt catatgcgat tgcacccatt 2850661 tcttcagctg cgctgagggt caacgcgaag gacttaaaca ggccgtttta tttaaaggga 2850721 atgagcatta tcgggccgct ttcctttata tttacagcgt ttatcgtgta ctggtcagga 2850781 tggaaaacag tctcctggct gctcggttca caactcgtga tgtttttgat ctatctctgt 2850841 ttcagcaaat atacgcctaa agaagatgtc agccttgctc agcagctgaa atcagcctgg 2850901 tggcttatcg ggttttatat tatgatgctg atcttttcct acatcggttc tttcggacat 2850961 ggtttaggga ttatcagcaa tcccgtcgac ctcattttag tcgcgatcgg ctcacttgcg 2851021 atttattact gggcaaagta taccgggctc ccaaaagccg ccattgatta tgataaataa 2851081 agaagcaaga ggttttcttg cttctttatt ctttacaaac aaacatacac gcgataaaat 2851141 gaatgagagt cagtcattac tggaggtgtt cctcatgcca aaacaaacat cgggtaaata 2851201 cgaaaaaata ttgcaggcgg ccatagaagt catttctgaa aaaggcctcg acaaagcttc 2851261 tatttctgat attgtcaaaa aggccggcac tgcccaagga acattctatt tgtatttttc 2851321 atctaaaaat gccctcatac cggccattgc agaaaatctc ctcacccata cacttgatca 2851381 aatcaaaggt aggctccatg gggacgagga tttttggacc gttttagata tattaattga 2851441 tgagacattt ctcattacag aacgccataa ggatattatt gtcctctgtt attccgggct 2851501 tgcgatcgac cactccatgg aaaaatggga gacgatctat cagccttatt attcctggct 2851561 tgaaaaaatc atcaacaagg ccattgcaaa ccatgaggta acggaaggaa tcaattcaaa 2851621 atggacggcc agaacgatta tcaacttggt cgagaatact gcggaacgat tctatatcgg 2851681 atttgaacaa gatgaaaatg ttgaagtgta taaaaaggaa attttcactt tcttaaaacg 2851741 gagcttaggt actgcttaaa aaatgactgg gtaacaccgc tcatttttta atgccctaaa 2851801 aatgactgac gttcattcat aaaatagaga ggtgtttcat ttgaattggg ttcttgtttt 2851861 tattgcaggg cttttagagg ttgtttgggc ctcttccctc aaacatgccg attcgctttt 2851921 ggattggatc atcattttta tcttaatcgc ggtcagcttt atcctgttga tccgctctta 2851981 tcaaaaaatc ccgatggccg cggcgtacac tgtgtttgtg ggaatcggaa ccgtcggaac 2852041 atatctgact ggaattgttc tgggcgaatc cttctcagca gcccaaatgt tctttttagc 2852101 tttattgctg gctggcattt taggaatgaa attatttacg aaagaaagca aatctcagcc 2852161 gggaggtgaa aaataatggc atggttttta ttagtgattg ccggcataga agaaattata 2852221 gctgccattg ccatgaaata tatagacgga acaagaaaaa aatggccgat cattgtgatg 2852281 actgttggat tcggcttatc cttttactgc ctgtcccaag cgatgatcgt cctgcctgcc 2852341 ggagtcgcat atgccgtctg gactggcatt ggaagcattg gtgtttcggc ggtcgggctc 2852401 atctggttta aggagcggtt tcagctttca caggtgattt cactttgcct tatcctagcc 2852461 ggcgtcatcg gcctgcgtct tacgtcatct tcataaaatc aaggcatata cagctgtata 2852521 tgcctttgcc attaagcttc gtgatgtttt tgaagatgaa gcggcggcgg gatgagccag 2852581 cctttgtttt ttagcagcct taagtatttt gcgccggttg ccgctttcga catatgaaat 2852641 tgcccaaaca tcatggcaat atcctcacga atcgattgcc ccatcatttt gctgcatgtc 2852701 acaagacctg cagcattttc tgctgccgcg gaagccgcca catccggatc gagaaaccgt 2852761 gcaccaggcg gaatatcgtt aagatctgct gtcggcggtt caggagaagc cggcggcagc 2852821 gccaccccgt tttctttcag gatcgtgctg acctgtttga tttcatcttg gcatttctca 2852881 atagactcac gaagcagctt cttcaggtcg tcatcaccga catgattcaa tagcatttgg 2852941 taattgccga ccattttatt gcccgccatc acataactcc acaagccgaa tacctcaccg 2853001 taatgcatcg gttcatcctg cggatttccg cttaaaatac ccatgctcat tctcctccca 2853061 tattcaatat tgcacatttc ataacgtgcc caagcggagg aacatttatg tttcagcgga 2853121 aaagatttat gaaatgaaac aaaacaaaaa agacaagagt ggcaagttgc caaaccattg 2853181 tctttcctgt tgtttgattg gacgcactga agggattcgc accccgacag acaagatacc 2853241 ggaaaccatt caagtgcttt ttagtatgag tcattgattc tgtctttaat aaactttaac 2853301 gagatggcgg gatgctttgc ggaaaacgaa atacattttc ggggtcatat ttcgccttta 2853361 tttctcgaag ccgcgcaaag tttgcgccat aatattcttt tccgaagttt tcaatgtttt 2853421 gatctggaac attaacatat gaacctgcta catatggttg catcagctga cgcactcttt 2853481 caactgatgc aagatttgaa tcttcttgtg atttattttt ccaactagcc gtccattccg 2853541 tataaaataa tggatggcgc caaaaaaagg cagtttcgtc tttagggact ctgcttatag 2853601 caccacccca attgataaaa aagaaattgg cttctgttcc agtagcatct tccaaaaatt 2853661 ttctcatgat tgaaatgggt tcgtcagacc aaaaatcatg accccatgcc gaggagaatt 2853721 taacactctg atcatttctg ccagggatgg gttcgtcagg gtctaagaaa tctatagcat 2853781 ctggatagta taatgttttg atatctgctt ctgttggagt tcccgcatgt aataaaggtt 2853841 ttaataatcg aatcaattca gttttcgaac cgaggaaaat tccttctgca tgacacaaac 2853901 catttatttt gctgtaaatt tcaaggtagc atcctaatcg ttcatctaca aacggagccc 2853961 atttctgcca agctttaaat accgtttcta attgttccca cggccagata atattgaaga 2854021 cggttgcagt tttaggggca cgatgaactt tgaatgtata ttgggtatta tatccaaagt 2854081 tacctcctcc tccgcctcta gaagcccata gcaaatcctc attgtgagat tgatctgcgt 2854141 gaataatcct tccttttgca tctaccgttt tcagcgcgag aaggttatca cttataaggc 2854201 caatcgatcg tgagagtaca ccaaatccgc cgcccatcgt aattcccccg attccaactg 2854261 ttgggctatc tccaaacgga gccataaaac cgtctcgagc taatcccttt acaagcgggc 2854321 caacgggaat accagtttga acggttgcaa tagcgttttc ttcatctaag aaaactttat 2854381 tcatgtcact cacatcaata acaattcctc cacttactac tgaaaggttc ttatctaaag 2854441 catggcgacc gcttctgaca cgtaagggca ctttattctc acgagcccat ttaatggcat 2854501 tacttacatc gtatgaattt tgcgcaaaaa caaagacaag aggatagaca tccacataag 2854561 ggttccaatt cttaatagcc tctgtatagc cggggtctcc tttgaagatt acacgccctg 2854621 tcaactgtgt tgatcccata tattatttca ctcccaaaga aattcgattc agatactaaa 2854681 atatgcagga gctggataat cgcatagaca aatgatctac gaactataaa tataatacgc 2854741 taaggccttt ttcgtcggtg aggtctgctg agaaacattt ttcaaacaat tttgagcaaa 2854801 cttcctgtcc aatcctccaa caagcgtttt ttcttatcgt ttttaggagc agtgtccagt 2854861 ttttttcgga gtgaatattc gtttaggcca aaagaaaaga gagatgaaga agtgtttagt 2854921 accagaggta tacatccata caacagactc tagatcatca tatactgaat gtatgtagaa 2854981 aggagacatc agctttggca aaatatcgga ttatgacctt tgacggcggc ggtaccttag 2855041 gtgctttaag tttacaacta ttaaacagat tggctaggca aaacccgaag ttaattagtc 2855101 gaacccatgt attttcggga aattcaatcg gttcatttac tgcccttgca ttagcaagcg 2855161 gaagatctcc gagggaaaca cttcagtatt ttgaggatga aatcctaccc gcattcagca 2855221 tttcccggcc aggcggacct gttttcaacc aacaattacc ctattccggt tttattaaag 2855281 cggtaagaaa ttttttccca gcagatcttc aacttataga tttaagaaaa cgaattgttg 2855341 tcccatcatt caaattatac tctcaaaaac tggaccgttg gactcctgtc ttatttcaca 2855401 attttcccgg ctctccctat ttaaatgaaa aagtgagtga tgtcatactg cggagcagcg 2855461 gtgctcccgc gacgcaacgc gcctatcaaa actatgtgga cggatatgta gtagcaacga 2855521 atcccagtac agccagtatc gcgtttgcag ttggtaaagc caacgtgcca ttggatcaaa 2855581 ttgcggtatt gtccatcgga acaggtgaag ccccgactcg gttaagaaga gatacgaggg 2855641 gatggggaat ggtaagtgca gataacatac gtcccgaaaa tctgaagaac cttcctccaa 2855701 attggggagt ccttttggac aggtcgccta atgaaccttt actgccattt cttcagatga 2855761 ttgctggcgg taatgggtac tatgaatcca tggtcagtgc gaatcttctg ggagatcgtt 2855821 ttttccggtt agatccgcgg attccgaact tctccaaaac ggaccctgcc gtcgttcccg 2855881 ctgtcattga aattgcgaac aaaacaaact tacagcctgc gaatcaattt atagagaaga 2855941 actgggggag caaataatta tttattttaa atcaattctc gcttatacaa ttttgtccga 2856001 gagaagattc tcaaaataaa tacaggcaat gggtagaacc ggattttttt aaaggtttgt 2856061 taatcacaag ctaataagat gaatgaaaaa atcaattcat acttcttctt ttgaaagtga 2856121 gggttcaaac taaagaatgt aattgaaatg ttactctaag gtatgcaatt ccctttttca 2856181 cacaaaaaaa gacaagagcg gcaaatcgcc aaacccttgt ctttcctgtt gttctattgg 2856241 acgcgctcgg agggattcga acccccgaca gacgtggtac cggaaaccac cgctctatcc 2856301 aactgagcta cgagcgcata tagactgcgt tatgagaacg tcagcacaac taattatacg 2856361 ataattcctt tcaaataaca accctctatt tcgagaggcc gttttttaaa tagacaaagc 2856421 atcttaattg gcaatctgac atacgatggt ttgaacccct gtatttttgg ggaaaatggg 2856481 aaaaagagac gactttgcat atcaggccag ctttttgttt gacctttatt gaccaaaaat 2856541 gtatcatgta actacatact tacctaaaag gtgaaggagg agcattatga atttaatacc 2856601 tacagtcatt gaacaaacga accgcgggga aagagcgtat gacatttatt ctcgtctatt 2856661 aaaggatcgt atcatcatgc ttggatctgc gattgatgac aacgttgcga actccatcgt 2856721 gtcacagctt ttattcttag cagcagaaga ccctgaaaaa gaaatttctc tttacatcaa 2856781 cagcccgggc ggctctatta cagccggtat ggcgatctat gataccatgc agtttattaa 2856841 gccgaaggta tctacaattt gtatcggtat ggctgcgtca atgggcgcgt tcctgcttgc 2856901 agccggcgaa aaaggcaaac gctatgcgct tccaaacagt gaagtcatga ttcaccagcc 2856961 tcttggcggt gcgcaaggtc aagcgacaga aattgaaatt gctgcgaaac gcattctctt 2857021 gcttcgcgac aaattaaaca aagtcctagc tgaacgtact ggccagccgc ttgaagtgat 2857081 cgaacgcgac acagaccgtg ataacttcaa gtctgctgaa gaagcgcttg aatacggcct 2857141 gattgacaaa attttgactc acacagaaga caaaaagtaa taacacaacc tgcaagagct 2857201 gcgtctcttg caggtttttt tcatttcaag gaattgactc ccttattcta tactgctccc 2857261 attcctcatg taacagctca agcgtcaaat cactcgtctg cctcacaacc agatcagcac 2857321 caagcatcgg ctgtccttga ccgacaccaa ccgcaaacat ccccgcagat ttgattgcag 2857381 aaatgcctgc ttctgcgtct tctattgccg cgcaatcagc aggggaaaca tcgagcatcg 2857441 ctgcagctgt taaaaagatg tcaggatcag gcttcccctt cgcaagagtc gtcggatcaa 2857501 caatggcatg aaaatcatcg ataattgcca agcgtcttaa aatcttagga gcattgcgac 2857561 ttgaagatgc taacccgatt tttatatttt cgtttttcaa ttgacataga agcctgccaa 2857621 tccccggtaa aagatcttcc ggcgtcaatt tgctgatcag catttgataa tcgcgatttt 2857681 tccgatgcat aagctcttgt ttctccgcat ttgtatactt tgtttccgcc ccgccaaaga 2857741 tcaatatgct ttcaagtgac tcttctctgc tgattccttt tagcctttca ttcatgtctc 2857801 tgtcaaaagg gatatcgatt tgttctgcga tgtgcttcca agcgagaaaa tgatattcag 2857861 cagtatctgt tatcactccg tctaaatcaa aaatgaccgc tttcatatac taatgcccat 2857921 cacagcttca taaggtttga ggctaatact ctttaagtca gcccgctcct gcggatagtt 2857981 tgaaattagc actttccaac gctcatgaat cagttctgga ggcgcttcga acagagcctt 2858041 ttcttccgat aaattcacaa cgacaagaag cttttcccct cgatattctc gaaggtaaga 2858101 aaagacctgc ggatcattct cctgcaacag ctgataatcg ccatatatca taatcttata 2858161 ttgctttcgt aattgaatga gcttctgata gtaaaagaaa atcgaatctt gatcttccaa 2858221 agactctttc acattgatat cttgatagcg ggaatttacc ggtatccacg ggtctccggc 2858281 tgtgaatccc gcatgttttc cggcatccca ctgcatcggt gttctcgcat gatcccttcc 2858341 ttttatcatc acggctttga caaactcttt ttctgacatc gttttgtttt cgacgactag 2858401 ttcacgatat gcattcttta tttcaagatc atcatacatc tccagcggca tatcgctgtt 2858461 gaccatgccg atttcttctc cctggtaaat aaacggcgtt cctttcatgc cgtgcagaac 2858521 cgttgcaaat gccttcgcac attccttacg cagtttcctg tcattgcccc agcgggaaat 2858581 aaccctcggc tggtcatggt tctcaaaata aagggtattc cagccgacat tcattaaccc 2858641 ggtctgccac cttgtcatcg tcttttttaa agcaatcaaa tcaaacggct tgatctgcca 2858701 tttcccattt ggcgagtttt gttctttatc aatatccata tgttcaaatg taaagatcat 2858761 attcagctct tgcctgcttg catctgtgta ctttttcgcc tcttcaatat cagagccgtt 2858821 tgcctctccg actgtcatgc agtcgtaatg agaaagcact tccctgttca tctcttgaat 2858881 aaactcatga agacgtgggc cgttagagtg ataacggccg acaatatagc tgcggctgtg 2858941 atccgtttcg tagtccggaa aatcggtgta tttagaaata gagccaatca catccatccg 2859001 ccagccgtca acgcctctat ccatccagaa tctcattaca tcataaactt cccggcgaac 2859061 ggcttcgttt tcccaattta aatcaggctg ttttttcgaa aagtagtgca aataatactg 2859121 ccctgttcct tcatcgtatg tccacgctga gcctgaaaag atcgatcccc aattattcgg 2859181 ctctgagccg tccggtttag gatctttcca aagataataa tcccggtaag gattgtcctt 2859241 cgacttgcgg ctttcagcaa accaagcatg ctcatctgat gtgtggttca cgaccaaatc 2859301 catgacgatt ttcattccgc gtttatggac ttcatcaatc agctgaaaca tatcttcatt 2859361 tgtcccaaac ttttcgtaca tgtttttgta atcgctgata tcatatccgt tgtcatcctg 2859421 cggggaatca aataccgggg agagccagat gacatccgcc ccgaggtttt tgatgtaatc 2859481 cagcttttga atcacacctt gcaaatctcc gaatccatct ccattggcat cataaaaact 2859541 gcgcgggtaa atttgataaa cgacagcttc tttccaccat tcactcatta ggcgttctcc 2859601 tttcacatcg tccctgtagg acaaccggtt cctcataaac gttcatgtgc agcggctcgc 2859661 cttttacaag ctcaaaaata acgcgctttt cgtcaaccgt cacattgatt aatcgatttc 2859721 gataattgat gttgaatgaa tattcgtccc attctttcgg caaaaacgga gcaaatgaca 2859781 gcgtctcatt cgcggtgcgc atgcctgcaa agccatgaac gattgccagc cagctacccg 2859841 tcattgaagt aatatgcaag ccttcttccg tatcatgatt gtaattatca agatcaagcc 2859901 ttgctgtgcg cttatataat tcgagcgctt tcttttccag cttgagttcg gctgcgagaa 2859961 tcgcatggac agagggcgat aggcttgatt catgaacagt catcggctca taaaattcaa 2860021 aatttcgccg tttttcttcc attgtaaaac ggtcattaaa aagataaatg ccttggagaa 2860081 catctgcctg cttaataaaa ttggagcgga gaatcttgtc ccatgaccaa ttctggtaaa 2860141 gaggccgttc cgctggatct aattcgtcaa ctgtttgcag gtctttgtcc aagaacgtgt 2860201 catgctgaac gaaaatttgc agttcttcac taaatggata gtacatgtgc tggatgattt 2860261 ctctccagac ttccaattct acttcctgca catccagatg gcggcgtttc tccgctgaga 2860321 tactttcgag actttgtaga gtatactcca acgtccaagc cgcaatgaca ttcgtatacc 2860381 aattgttgtt aacgttgttt tcgtattcat tcggccctgt gacgccatgg atcatatact 2860441 tattttttcg tttcgagaag tgaacacggt cggcccaaaa tctgctgact gccacaagta 2860501 cgtctatccc gtattcttcc atatagttac ggtcgcctgt ataattgata taattgtaga 2860561 tcgcataaca gatcgcgcca ttgcggtgaa tttcttcaaa ggtgatttcc cattcgttgt 2860621 ggcattcatc acctgtgaac gtcaccatcg gataaagtgc ccccttcatc cccaattttg 2860681 cagcgtttcg tttggcagcc tccaactgat gatagcgata caaaagcagg tttttcgtca 2860741 cctccggctc ggctgtcgcc aaatacatcg gaacggcgta cgcctcagta tcccaatatg 2860801 cggcacctcc atatttctcg ccagtaaatc ctttcggccc gatattcaaa cgggcatcgc 2860861 ccccgtaata tgtcgagaat aactgaaaga tattgtagcg gattccttgt tgaagctcct 2860921 catctccttt aatctcaatg tccgcttttg cccatctttc cttccatcga tcagtgtgcc 2860981 tccgttttgc atcttcatag ccgttctcta ccacatccgc caaaagctcc ttggctttcg 2861041 ataaaagctc ttcctcccga aaatcacggg aagtcgtgac aatcacaaac tttttcaatg 2861101 atgccttcgt ttgataactg tagcgattct cgacatacat ttcagtcgtt ttaaagcttt 2861161 catggacaaa accctccgtc tcgtttgcca ttgcggctaa taccgtgaag cgcggtgttc 2861221 caaatggatt ttcgatcgtt tttgccgcta aatggccgct gtgagaatca gcacctttcg 2861281 cttcctcctg ccaaaactgt tcttggtagt tagaatcttc atttgccaca tttccatcca 2861341 ggtaaggaac aagcgtaatg acagcatctc ccgtcaagca ctccgcttca taatgaatcg 2861401 cacagagttc ttttacagca aggctaagaa accgctctga cctgattctg acggttttat 2861461 cttgaatgcg gacaacagcg cttcgccgca gaatcccctc tttcatattg agttctacct 2861521 caaataattc gattgggttt tgatggagat cgattttttc accgtcaaca tataggccta 2861581 tgcccataaa gttcatcgca ttgatcactt ttccgaaata ttctggatac ccgtttttcc 2861641 accagcctac tcgcgttttg tcggggaacc acacgcctgc aatatatgtg ccttggtgac 2861701 tgtcgcctga atagccttct tcaaaattcc ctctgacccc catatagcca ttggcaagag 2861761 acgtcaggct ttccagcagc cgtgtatgct ccttattaaa tgtatttgtt ttgattttcc 2861821 attcatcaat ctcaaataac cgctgattta tcatcatttc ctcccgaatg taagtttcca 2861881 ttatcacggc gggttttggt caaatatcta aatgcaaaag agatcatcaa agtaacgcca 2861941 cacgaatgga tcatcaatac agtaatcaaa tcaaaatgaa ccatgccgat agcagctgcc 2862001 gcaaatgccg gcagtgctga tgcgcaaatc gctatagagg ccgcttcctt gaatgatgca 2862061 atagagacca tgtttgatat ttttgtgatc cagaggccac ctgcaagaac aaacgttaac 2862121 aaaagctgga tcatagaaac caccgtatat gccagcatca tgatcatcgg cttatactgt 2862181 gccaaccaca atgtatcgat caagacctct acatcatgga cgtttggttt ctcgagctta 2862241 acgtccattt tcgcatagcc aacagaaaac cccgtttcgt tttgatcggt gatcaccagt 2862301 tgatcaggtt gaaatatgat ggcgttttca aatccagtta ctttcaatcg cccattttca 2862361 ccgcttgtct catattcatg cttcatatcg actgccatca cattctgccc atcttcaatc 2862421 ctctcagagc tcttcccgcc tgttagtttt ccgttcctga tttgaaaacc ctgcaattga 2862481 tcagcaaatt gatcattaac tccttgaatc gctgacggca tgaaagatga aacgctgaag 2862541 cgatccattt tcacaaacga aaccgctaac ggcgccatta agcaggccgt taaaaacaga 2862601 aagagaaaag agagctgcag ccagctgaag gtattcccat agcggcaaac acctgatggg 2862661 gatgcagccg ccttcaggca gcggatgata aagcttttat tctccagatt cttcattggc 2862721 attacccctt tgttccgccg gctgtcaaac cggacacaaa gttcttttgg agaaaaaaga 2862781 atagaacgca tatcggcagt gcggctagta tggcaccggc tgcaaataga gctacttttt 2862841 gctgctgcgg attagaaata aaggattgta atcctacagc gatggtcagc ctttccggtg 2862901 agcgaagcag aaatttcgtc agcaaatagt cgccaaacgg tgccataaac gcccaaagcg 2862961 cttgtaccgc gagcattggc ttaacaagcg gtagaacaat tgaagcgaaa atcctcagat 2863021 gtcccgctcc gtcaattcgc gcggcttcat caatttctct cggcacagta tcaaaataac 2863081 ctttcatcag ccacgtgttc atcggaattc cgccgccgat atagatcgct gttaaaaacc 2863141 agtattgatc gagtgcgcct attagcatcg ccaagacata aaaagcagtc agcgccgcca 2863201 ttgtcggcac catttgaatg attaaaaaga atatcaggct cttttttctg cctgcaaacc 2863261 gatagcggct gtacgagtac ccggcaagtg tcacaatcgt aacctgcaaa accatgaccg 2863321 atagcgcgat gacaagtgta ttgctgtacc aattgagata aagcgtttcg tcaaatagcc 2863381 gcttaaaatg atccaatgtc caagaacccg aaaaatcgag ctgaaaagcc gccgaattcc 2863441 ccacacggaa ggctgatgat gccgtaatca gcaacggata tataatgaca atacttaaaa 2863501 gcgtcaaaaa taaatacgta cagattttat taagcattct ggcagtgctc gcgttcacct 2863561 acataacctc ctcattgcca aaagcattcg attttttgaa agcaatcagt gaaattccaa 2863621 tgacaatgaa agaaattaac agtgtcacag ccgccgcaac ggaatattgg ggtgatgtgc 2863681 ctgttgtcag tttataaatc cacgaaatta agatatcggt cgatccggcc ccggctcccg 2863741 cactgcctgg ccctccctca ttaaataaat agatgatcga gaaattattg aaattaaacg 2863801 tatactgagt aatcatcacg ggtgctgtgg caaataaaat catcgggaat gtaatatgcc 2863861 gaaaacgctg aataaaagtg gccccgtcaa tctttgccgc ttcatacaat tcacctggaa 2863921 tcgcctgaag cactcccgtt accatgacat atatatatgg aaagccgagc cacgtttgaa 2863981 tcataatgag ggctgtcttt gtccagaaag gatcggtctt ccacgcgatc gcaggcagct 2864041 cgacaaacgg caggtgattg aataatggta tcacctgtgc attcaccgct cctatgctgt 2864101 cgttaaacat gttggaaaaa ctcatgattg taataaacgc cggaacagcc catggaaata 2864161 agaaaatcat tcgaaatatc cgcttgcctt ttataaaatc ctgattgacg aaaagtgccg 2864221 tcacaatacc taaaatgatt tgcagcgttg ttgcacagat tgtccagata accgtccagc 2864281 ccagtacatt cacaaatgtt tcacgatagg agccaaggaa aaaaatattt aagaaatttt 2864341 taaacccgac ccagtcaatc agacgattag gcggaatatg ataaaaatca tagtttgtta 2864401 atgcaacaaa cagagtcacc aaaaccggaa aaataatcac aaacaccatc atgatatatg 2864461 ccggcagtgt aaatagatac ggaaaacctt tatcgcccgc atgacagatc atatccttgg 2864521 ctgttgtatt gacttccaaa cccgccgctt tcatagcggc ggtcttacgt gaatcatgaa 2864581 tattaaagat atagaacatg aggaaaatca ttgtcacgat caattgcagc gtgccttcaa 2864641 tcagcataaa cagcgagtga tcttcaccgg gaacacttcc caatgtcatc aatccggtta 2864701 gcgcctgtat accgaaaacg cataattcaa aagcaaacaa gcctgtgatg gcaagaaata 2864761 agagcccctt tgacaactgc tgattcgcaa tctgcccaag tcctggaatg atcgataaaa 2864821 gccctgcctt tcgtttttgc tttgtaagtg tgtgatgttt attcattttt ccgccctcta 2864881 ttcttccgga cgctatcccg ccgttttatt tcacatactt ttctttaata ttttccttta 2864941 tgacgtttac agcatcattc gctgatgttt gtgtcgattt ttttcctgaa gctgcatcaa 2865001 aaattaaact ttccgctcct gtccatactt cagccatttc cggaatattt ggagtcggcg 2865061 ttgctgtttc atattgttta atcacagctg acgtcagttc attcttttgc tcatcggctt 2865121 tcttccttgc agccgtgttg gccggaactt cgtttgtatc ctcataaaaa gcgtaagcat 2865181 tggcatcatt tgcagcatac tcaagccatt tttcagccag ctcgggctct tttgtatatt 2865241 tcgaggcaac ccagcccttc ccgccagcaa aaggggcgta ttcttctcca tttggcaatg 2865301 tcggaatggg agccgctccg tagttcaatt tagcctcttt atagttggca gctgaccaag 2865361 gaccgccaat gatcgcagcc gctttgcctt ctaaaaacat ctgctgaata aagtcgtctg 2865421 cgcttgaatt gtcttgcatt cctttcggcc aatatgtctc aaaccatttc tccgcatatt 2865481 tcaccgcttc tacagcccct ttattgttca ggccgatgtc cccggaatct gtgccgtttt 2865541 ttccaaacac atatccgccg tatccagcca ataagccgta cgacatataa aagtcagtcc 2865601 attttgctaa aaatccggtt gattttcctt tttccgaagc aaacgcgaat cgaggatctt 2865661 ccgttaactt ttcaaggtct ttaaatgttt ttggcgctgt ttttaaaaga tctttgttgt 2865721 aatacaaaat aagtgtctca atgactagcg gcattccgta cactttgccg tcaactgtca 2865781 cctgctgcat ttctttatca ccaaagcttt ttgtgttaga tggcttaata tcaagtaaat 2865841 gtccttgttg tcccaaaccg ccgatccggt catatgcagc aagcataaca tcaggcgcat 2865901 tacccgccgg gccatcaaga ggaagcgctt ctaactgttc gaacatttgc ttttcaacaa 2865961 tttttactgt gacatcattt tctttttcga actttgtttt tatgctttca atgtattctt 2866021 tatacgtttc ttcgacagac acagtcagca cctttttgcc atcagagctt gctggatttt 2866081 ttgaacttga gcaggcggca aggccgattg ccaggaatga tgccgccaat atggcgaacc 2866141 ccttttttaa aagaaccatc tcttttcctc cttctattta cgaaactata acaattgtat 2866201 tgtcctatag aaagcggtta caacaacttt cgatttgtta ccgataacag aatgttatac 2866261 aggggcggca gcactcaaaa tcaaaaattc tcccggctga acggcaatga catcgtgatg 2866321 ctgtagcggc tgctctgtcc atgcatcaca gattttctta ttcctatcaa tattcaactc 2866381 tcgtaaactg acgtgttgaa ccacattccc ttgattaaag aaataaatca gtattttttc 2866441 atcaagagtc cgcgaaaagc taatgaaatc atttttgtcg tccagcagat tccactcaag 2866501 atgtccttca gtcaataaag tgttttcctg cttgcgtaaa gcaattaacc gtttcataaa 2866561 ttgcagcatg tcttggtttt gcttctcttt ttcccaaacc atacatttcc ggcataatgg 2866621 atcattttcg ccgttcagcc cgatttccgt tccgtaataa atgcatggtg agcctgtctg 2866681 ggcaaacata aaggccagca acgcgcgtgc tttcttctca tcattgcggc atctggtcaa 2866741 aaggcgcttt gtatcatggc tatccagtaa attaaacatc acctcattgg cctgcttcat 2866801 tccattcatc aaatgtgcat tgacacggtg agccatacgt gaagctgaga tcgtctggtc 2866861 agcaaagtat tcaatcatag gctctgtaaa agggtaattc atcgccgcat gaaattcatc 2866921 ccctctaagc cagggttcgg cagaatgcca gatctcacct aaaatataaa catcaggctt 2866981 ttcagtagat acagcctgcc taaatgtctt ccaaaaaacg tgatccactt catttgcgac 2867041 atccaaacgc cagccgtcaa tgtcaaattc gcgaatccag tacaaagcaa tatcaagcaa 2867101 atatttctgc acctcgggat tagccgtgtt tagcttcggc atatcagctg taaaagcaaa 2867161 tctgtcataa ttgtcgtctg tgacgggaaa agagtgaata tggaaccagt ccttatagcg 2867221 ggattgatct ccgtttttga cgacatcctg ccattgcgga gacgcgcttc ctatatggtt 2867281 aaaaaccgca tcaagcataa ttctcatccc ccgctgatgc agctggctga ccaatgtacg 2867341 aaaaagctca ggatccccga aatgcggatc aatagaaaag taatccagcg tgtcgtattt 2867401 atgattagaa ggcgcggaaa agatcggtgt cagataaatg ccgttcaccc ctaaatcctc 2867461 taaataatca agcttgtcaa caattccttg taaatcccct ccaaaaaaat cattgacgtc 2867521 cgggtccttg ctcccccacg gcaatgcatt cttcggtgac aagtcttctc ttccatttgc 2867581 aaaacgctcc ggaaaaattt gataccaaac cgttgacttg acccattcag gcgcttgaaa 2867641 tgtatcagcc tcgtgaacaa acggaaattt aaagtaataa tgaatcgttt ccagtgtttt 2867701 ttcgttataa gggcatacac ccgaacttcc gaaaaagatg tcttcatgat cgtctgttac 2867761 aacaaacgca tattgtaaac gcctaaatgg cggcaccact tcagcaaacc aatagtcatg 2867821 catttctgta gcagcaattt tcctcatcgg ctgctcgttt gccgaccatt tgccgtcgtt 2867881 gtactcatag ggatcacccc aaatgaatcg aatgtgatct gcatcacctt ttttcgtccg 2867941 aatcttgata tgcacagtcc gcccatcata agaataagca tctgtgctga atggctggtg 2868001 atgaatcgct gcatattcca tcatgtttcc ccctttgatt tccgttttat tgaagccggc 2868061 tcatagtttg aaagtatcat gatgaaattg tgggaacaat ccttttcacc ctgttaccga 2868121 taacagaata aggcgcttac agcgttgatt ctcgtacaat taactctggt tcaaaaaata 2868181 gacttccttg tgcagcgccg tcttcattca tttttttcag caacattttc gcacaggctt 2868241 cccccatttc aacaacaggc tgtctgaccg tagtcaagcg cggcgaggag atgcgatcaa 2868301 gaaacacacc gtcattcccg gtaaccgcaa cgtcttctgg aattcgcttt ccaagggatt 2868361 gcgccgcacg aatgacgccg agcgcgattc gatcagatgc gcagacaaat gcggcctgat 2868421 tgtccatgga tttcagcagt tctcttgcaa ggcattcact tttcttagaa ctgttgtcga 2868481 tccgaaacat attcgatttt ttaaagcttt tattcatcgc ccgtatatac ccctgttctc 2868541 ttgcacgttc gaaaggctca tctaaatcaa tgccaaaaaa gacaacttcc cgctccccca 2868601 gccccataac atggcgggtt gccataaaag tgcctttctc gttattcaca tcgataaagt 2868661 catagcccat ttcattttgt ccaaatacga cgagcggctt ctcaaaagct tttattacac 2868721 cttcaaaatc gttctttctc aagccggtgg caataatgcc gtcacattgg ccaatattaa 2868781 gagaatttct tgtcacaagc tggagagcat agtgattgcg atccagctcc ctgctgattc 2868841 ctgtcagcag gttcatgtaa tatggttctg tcgtatccat ttcctcaagt atcaatagtt 2868901 tcacaacctg tgttctgttt tgcacgagcg ctctcgccgc ataattaggg atgtaattca 2868961 gctctttcat cgcagaatga acaagctttt tcaattcatc cgtcaccgtc tcagggtgat 2869021 tgatcactcg tgataccgtc attttcgaaa catttgcttt tttcgccaca tctgacaatg 2869081 ttgccatttt catcccctcc ttatctgtgc ttattatcca aactagtgat aaagtcctct 2869141 attactgcta aatatacgat gcaggccaaa gagaaataaa aaagagattt cccttaagga 2869201 aacctcactt tgttaaaaac actcgatttt tcatggattc atacgctagg tggcagactc 2869261 attctctcca cttccatcag aaaatctctt ttttaaattt ctgtccactt tttttctaaa 2869321 atcggataag aataattttg catttgctca attaactcat ccggccgtga cgagctgtga 2869381 atcagtttta ggtgcgattc gttagaaaac ccttcttgaa tgctgtattt caccattttc 2869441 atcattggtt caaaatatcc gtttacattg tacagtccaa ttggcttttg gtggatgccg 2869501 atctgtgccc agcacagcac ttcaaataat tcttcatatg taccgaagcc gcccggcatc 2869561 gagataaagc cgtccgccag ctcgctcatt ttagcctttc gttcatgcat cccgtttact 2869621 tcaatcagct cagtcagatt ctgatggaca acctccccgc tgaacaaacc gctcggcatg 2869681 accccgattg cagttccgcc gttttccata atcgcgtcag caatcgtgcc catcaagcct 2869741 acgcgggagc ccccatagac aaggccgatt ccctgctcag ccatatacac gccaagctct 2869801 gccgcttttc ttttatacgc ttcatttccc ccagggtttg atcccgcaaa tacacaaatg 2869861 gttttcatct tgtcatctcc gcatctatat atcgtgttaa acattcaaaa acacactata 2869921 tattgtccca tcttcatgtg ataatatcaa tatgaaatac ataaagaatg caggagtgat 2869981 gaggttgcag ctggctgatg cagaaaaatg gatgaaagag ttttacgaaa aaagaggctg 2870041 gacagaatac ggacctttta ttcgcgtcgg ctttttaatg gaggaagccg gagaactggc 2870101 ccgggctgtc agggcgtatg aaatcggcag agaccggccg gatgagaaag aatcgtcacg 2870161 cgctgagcaa aaacaagaat tgattgaaga aatgggagat gtcatcggaa atatcgccat 2870221 tcttgctgat atgtatggtg tctctttaga agacgtcatg aaggcccacc aagaaaaact 2870281 gacaaaacga tttgagcatg cataaaaaag cggccgcgat ggccgctttt tttaacctgt 2870341 gatttcatca tggtgatcaa agaaatgctg ctttcctatt ttgtgaaaaa ggcctgtttt 2870401 atgcagtagc tccttcggct gcgattgcaa tcctacaatc atcagctttc cattgtggcg 2870461 tttaattcga ttcataatgt tcccaagcac cgcttcagct gacgtatcca tatagtgcac 2870521 cttattcatg agcagaataa gggttttcgg ttttttctgt acatgctcca gcaatgacga 2870581 ttcaagggaa tcaattgatc cgaaaaacag cggcccttct atggcataca tgctgacaga 2870641 tggatcttct ctcttcgcca gaacaggatg cgtttcctga ttgtggatgc gggtcgcttc 2870701 gctcattctt ctgataaaga acacgaatgc aagcagcaat ccggttgcca caccgatgat 2870761 taagtcaaac agaaccgtaa gggcgaaggt cgccgccaaa ataaaggaat cagcattttt 2870821 cagtctcagc atgtttgcga cttccttgcg ctcactcata ttccatgcga ccaccatgag 2870881 aatcggtgcc atactggcga gcggcacatg ggacgcataa ggcgcaaata caagcaggac 2870941 aaggagaacg actacgccgt gaacgacgcc ggaaactggg gaaaccgctc cgttttttat 2871001 attggtcgcc gttctcgcaa tcgctcctgt agccgggatt ccgccaaaca ggggcgctgc 2871061 catattcgca atcccctggc cgacaagctc cttgttgctg tcatgctttg agcccttcat 2871121 gttatcagcg accattgcgg acaaaatcga ctcaagtcct ccaagaagcg cgatgacaag 2871181 cgcagccgga aacagcataa ccattttatc caaagtaagc tcaggaaact gaaattccgg 2871241 caaatggcgg gggatttctc cataagttga cccgatcgtt gccatgcggt cagggaaaaa 2871301 gacaaccgcg accactgtgg aaataagaag cgccaacaaa gcgcccggca ctttaggcat 2871361 caccttggcg gatacaagca aaatgacgag cccgatcaca gctgtcaaaa tggcatacac 2871421 gttaaaggtg ccgagctgct gcacaatttc aaacatgttg tgatgaaagt tctcatgttt 2871481 ttcaacattt ctcaatccga gaaaattagc gatttgttcc gtaaagatca gcacggcaat 2871541 tccggctgta aaaccgacga taacgggttt gggcacgaat ttcattattt ttccgagctt 2871601 aaacagccca aacagtacca gcatcactcc tgccataaac cccgcaatca gcagattttc 2871661 caagccgtac tgcatgataa tgccgaataa aatcgggaca aaggcgcccg tcggaccgcc 2871721 aatctgatat tttgatcctc caaacaaaga aatacaaatc cctgctataa caacagtgta 2871781 tagcccatat tcaggctcga ctcccgaggc aatggcaaac gccattccta aaggaattgc 2871841 cacgacacct actacgatac ctgcaatcaa gtctttctga aatttctgca aattgtatcc 2871901 cttgaatctc cctgagaatc gcatattttg ttataacctc ccttatgagt gattgtttat 2871961 aagctcagtt tcataaccgt taatgaccac atcaagtttt cctgtttcag ggtgaatgac 2872021 aagcccgtga accggcactt ttttcggaag cagcggatgg ttcttaatca tgttcacact 2872081 gtgggaaacg ctttcttcca cgctgtgaaa accagtcagc cacgttttca aatcgagtcc 2872141 ggcactcgtc agcaaattca ggcagctatc ctccaccccg cgttcctttg ctttctcaag 2872201 aatcgaggac gcattcagcc ctgacattcc gcattcatga tggccgacaa tgcatacctc 2872261 ttcagcctgc aattcataaa tcgcgaccag tatgcttcgc atcacgcttc caaatgggtg 2872321 agaaacgatg gctcccgcgt tttttacaat tttagcatca ccgtttttaa gccccattgc 2872381 ttgcggaaga agttctgtaa gccttgtatc catacaggtg acaatgacga gctttttcga 2872441 aggaaacttt gtcgttttgt acggttcata cttcttctca ctgacaaacc gctgattgtg 2872501 ttccaaaatt gatgttaaag aaaccatttg attcatctcc catccatatg attttgcaag 2872561 ccttcttacc cagcttacag taaggaatta tagcatagga ataagccaag aaaaggtttt 2872621 caaaaaaaga cactataatt ggactgtaga atcaaaacat aaacatttat atctttcaaa 2872681 gataataaaa tttatattta atgcatccta taatccggct gcagttcgta tatcgatgat 2872741 ttgtctgaca aaaaatatgg gtgaattctg ataattaaaa aactttttta agcagattta 2872801 gctgttcgat cttcatttta agttcaaaag aaccagaaat taaaaaaacg cagctatatt 2872861 tttaacatct atttattttc gatataatga attagacaac agccataaag ggggagcctt 2872921 gttgaaacca tttgtattta tcacaaaacc gattcctgaa gagattgaag cattcatcgg 2872981 tgaacattgc cgttatgaag tatggcagga ggatacgctt ccgagtgacg tgctatttga 2873041 aaaattaaaa gaagcggagg ggcttttaac atcagggacg tccggaccgt caatcaatcg 2873101 tgagttgctg gaacacgcgc ctaagctcaa agtggtcagc aaccaatcag taggctacga 2873161 taacttcgat atagaagcaa tgaaagaaag aggagtcgtc gggactcata caccttatac 2873221 actggatgac acagttgcag atctggcttt ttcactgatt ctgtcttccg ccagacgtgt 2873281 tgccgaactg gaccgttttg tcagagcagg aaaatgggga accgtggaag aggaagcgct 2873341 tttcggaatt gatgttcatc atcaaacgtt aggcattatc ggcatgggca gaattggaga 2873401 acaagcagcg agacgcgcca aatttggttt tgatatggaa gtgctttatc ataaccgaca 2873461 tcgcaaacaa gaaacagaag acagcatcgg cgttaagtat gcagagcttg atacattgct 2873521 ggagcaatct gattttattc ttctcattac gccgctgact gatgaaacct atcacatgat 2873581 aggagaacgc gaatttaagt tgatgaagaa ttcagcaatt ttcgtcaata tttcccgggg 2873641 aaagacagtt gatgaaaaag cactgattcg cgctcttcag gaaggctgga tcaggggagc 2873701 cggcttagat gtatacgaaa aagagcctgt cacccaagat aatccgctcc tgcagctgga 2873761 taatgtcacg ctgcttcctc atatcggttc agcaacagct aaagtgcgct tcaacatgtg 2873821 caaacaggcc gccgaaaata tgctcgcagc gatccaaggg caaacaccga aaaatcttac 2873881 aagagaattt caataaatca aaaatccggt ctgataacag accggatttc atattacata 2873941 cgctgaagaa cagcacgctt ataaatatga cgggtgacga tataataaag agcctggaat 2874001 acaaaataaa tgaagatgac aattacggcc tcaagaaata aattggaatt cagcatatta 2874061 cttaacgctg catacgcaaa gcccgcgtga atcgtacctg cgataaatgg gatgaagaat 2874121 aaaaatccta tttgctttcc aaggatcgag tgaatctctt tgtccgtaac ccctatcctc 2874181 tttaacgcta acacctgcac tcccgtatct tctatttccg taaacatccg caaatacagc 2874241 atgcttcctt gcacgataaa aaacagcacg ctgacaaaca gaccaataaa cagcattaat 2874301 gcaactccct gcttcacaat ttgataacta ggagcacgtg tttgaaaatc agatgtatgt 2874361 tctttcggca ccatgttttc aagcttttca gagacatcca ccgtctcctg ccaatgctca 2874421 agctcataac ctaccattct catctgttcc ttcagcggca catcctgtga cagactgtca 2874481 aagctctttt cgctgacaac caataaacgg ctgactccat cgacagacat caatatccct 2874541 ttgttttgct gctttttcat gacataggaa agggtttttc ctgacttcat atgaaatgct 2874601 gctgtttccc cttctccaaa tgtgtctttc accatcattt gaaaagaaac attaataaat 2874661 gcttcatttt cttgtaaatg aataactggg aacccttttt cctttgcgac ttgattatag 2874721 actttttctg aaatcagcaa agcttcagct tccatcttct tatttccata cggcaagtct 2874781 gactgaaaag tgacaggaat ccctgtggca tccaccttat acgtgataac agcatgagct 2874841 tttttcaatg tattctcagc cgtctcaggc ttcatgacct gaaagcggga agcatccttt 2874901 tccacccagg aaacagactg aggaatgctt tgctcctcct gcctttgtaa atcggaataa 2874961 aacatataga tgacacctgt agctgttagt atgaccgctg taatgacaga ggttaaaaac 2875021 agcatgcgtg catgatcctt cagcctgaat atcatgttgg aacgcacaat gatatttgtg 2875081 cctttgtaga agctgtgttt ctttcggtac agcatgcgga aaaatgccac actgctttgg 2875141 gtaaaaaaga aatacgtgcc aattaacact aaaatcaaaa ttggaaaaac ccgaaacatc 2875201 atgtcaattg cattggctgt tgcagataga taataaccgc tgccaagaca tagcaaagac 2875261 aatacagtga gccatttcga ataaactggc aaacttttcg gctttttggc tgatttaatc 2875321 agttcaatga tttccagctt ccgaatccgt cccagtgata aaatgagcag cgtctgaaac 2875381 aggatgagaa agccggcaat tgtcatcaca aacgctttcg gcacaatggc aaacgaaatc 2875441 ggcaccttca cgctgagcat ccatgtcatg atcataaaaa acagttttga aaataacagg 2875501 cctgctccaa tgccggccgc aatcgccgca agagaaataa gtgactgctc ataataaatc 2875561 atcttgcgaa gctgctgctt tgatgtgcca aacagtgtca gcagcccaaa ctctttcttt 2875621 cttgcctgca aaaacgctga attggaatat gtgatgaaaa atatacaaaa cacaatgatg 2875681 acgacaagag ctgcgctcaa gcatgttttg acaaggcttc ctccatatat attgtcttca 2875741 ttgacatcag gatgaaaaat aaatgatgtg aagacaaaaa acaccgaaac ggcaaacaca 2875801 cagcttaaaa agtaggccac ataccgttgc agattcccaa gaatgttttt acgggcgata 2875861 gttctcaaat tcatgaaaat cgcctcccaa cacactcaag gtatccaata tactttgata 2875921 aaacacctgc ctgtttgttc ctctgtgaat ctctgaaaag aaacgtccgt ctttaataaa 2875981 aacaatccgt ttacagaaac ttgctgctgt ggcatcatgc gtaaccaaca aaatcgtcgc 2876041 ttccttttcc tcattcagct gagccagtgt gttcatcact tgctttgccg attttgagtc 2876101 gaggtttcct gtcggttcat cggcaagaat gagcgccgga ttgtgaataa tcgctctggc 2876161 acaagctgcc cgctgctgct gtccgcccga cacctcatat gtgcggtgat cgagaatatg 2876221 ctttatttgc agcgtatccg ccagttcatc caatcgagct tccatttctc tcagctttac 2876281 cttatccaat gcgagcggca agagaatatt ttcacgaatc gtcagcgtat caagcagatt 2876341 aaaatcctga aagacgaagc cgagttctct tctgcgaaac aaagccagct cttggtcctt 2876401 taacgttttc ggctgaatgc cgttgatcat catctcgccc tgggtcggct tatcaatggt 2876461 agccagcaaa ttcaaaagcg tggtttttcc gcttcccgac ggccccataa tcccgacaaa 2876521 ttctcctttt gacacactga gatcaaaggc gctgagcgct tggtatgata ttgttccttt 2876581 atttgaatag tatgttttcg ataggttcgt tgtttgcaac acgttcatgt tctgctcctc 2876641 ctttttcttt attataaaaa ggaagtcagc atcctcccat cgaactttct tgcaattccg 2876701 ctccccaatc ttacaatgct gtcacattca cgagggtgtc acttgaaaac acgatggtca 2876761 tcacagtgcc agccccttct tttgattccg catacagctt atggccgaga cggctgcaca 2876821 cctgttttgc taaataaagg cccattccag ttgcctcttt catggttcgt ccgttttctc 2876881 cggtaaaaaa cgcgtcaaaa atccgcggca gatcctgcgg cggtatgccg attccttcgt 2876941 cggcaaccga caagcgcgtc tcatgtccct gtgtttcaat ccggattgta atagggtctc 2877001 ccacaccttg ctttgaatat tttaaggcgt tgaaaaggat ttgctcaaca acaaaggaaa 2877061 gccacttttg atcactggaa atctgaacgg catttggcgg cacatgtaat gttggaaaaa 2877121 ggcgccgctt gataaactga cgtttttcct gattgatcag tgaacgaacc atttctgcca 2877181 aatcaaaggt ttgcggcttt acatcaaatg caaattcctc cagccgggcc gtttgcagca 2877241 tcatatcaag accgtggcga aatctctcat tctcatcctc cagctcctct aaaaacgtcg 2877301 gaaaagagga tgaggttccg ttttttcctt cctgaatcat taaggatatg acagataccg 2877361 gtgttttcat atggtggacc cattggttgg tgaaggtgta atgctgtttt tgctgattga 2877421 tatattgtga gagcctgctt tcgtattgct gcccgagtgc gttgatcatc ttcgtccaaa 2877481 gcgcttgctc tcctgttctt ggctttctgg ctttcaaaga ctgtccgatg tcattcgaag 2877541 aagaggcttg ttctgcaagc tttttaacat atgtgagaaa ggaaaattgc cgaacataat 2877601 cagcagcaaa acctgcggct aaaagagtac cgggcaaaat ccatatgtac atcatatttt 2877661 ctttggaagg ttctgcgccg ctctctacaa tgcttaaata cgcaatcagc atggcggacc 2877721 ctatccctaa taatgaaaat agaataatgg ctaagcggtc gatgagataa gtctttaaca 2877781 ttccgcttca tccttccgat tgacttgaaa ttgataacct tgtcctctga ttgtggaaat 2877841 gcaatctgtc agtcctgcat tctccagttt tctccgcagc cgattgacat tgaccgttaa 2877901 cgtattgtca tcgacaaaat caacgtcatc ccataacgcc tccaatagtt catcacgaga 2877961 gacaattttt ttatgctccc tcacaaaaat cgagagaagc tggaattctt tttgggaaaa 2878021 caaaatccgg acgctgttcc attcggcctc attctgatca ggataaatcg tcagcccgcc 2878081 aagctccact attctagatt cctgcggcaa agagggcgaa tattcaccat atgtgcggcg 2878141 caggacgctt ttgattttgg ccatcactac ctctagatgg aacggctttg tgatataatc 2878201 atcgccgcca ttttcaatcg ccattacctg attcagctca tcggtccgtg ccgatataaa 2878261 gataatcggc gcattggaaa tggtacggat ttgcctgcac caataaaacc cgtcaaaaaa 2878321 aggcaggttg atatcaagca gcacaagatc aggcttcatt tctgcaaatt ccaattttat 2878381 atcattcagc tgttcagcaa ttttcacttc atatccgtat ttttgaagat gaccgcccag 2878441 caaagaagca atccgctcat catcttccac aagcaaaatc cgatacacgt tgatccccct 2878501 tatatgtaca tcacgatgat ttttctagaa gattccaaaa ttattatagc atgtgcggaa 2878561 tagtaaatcg gtctttttct ttttgttatg atagaatgat aaaggtaaaa ttttcataat 2878621 aggcaggtgt cgtgatgaag aaaatcatgc tgtttctggc aatgacgtca attctttcag 2878681 catgtcagcc caactatacc gggaaataca tagaaattgg ggatacacta actgactata 2878741 ccaaagagtg ctttaaagag aatgaaattc cttataaata cgaaaaggga aaactgtata 2878801 tcccagaaga cgcatttgat acagcaatct acacttgttc ataagaaaaa gcttgcagat 2878861 aacctgcaag cttttcacgt tacaaaaaat gagtatttaa tttctcttca aatcctgaag 2878921 ggccgatgtc gcttttttga atgttaccgc cgttttcata aatcgtaaaa tggcgctctg 2878981 acatgaccat ccttccgctc ggcgtcagct ttgaggcaag cagggatttg ttaaaaggag 2879041 atttttcatg agagtgaatg atgtccttca tgttatctaa atcaccgaga tcactctctt 2879101 caagggtaaa ggcgtaccca atttgccagc cttctccttt gtccatcagc agaacatagc 2879161 tgcccttttc tgtctcttcc tttttgattc ggaatgaccc gactggtgac tgtaccgttt 2879221 ctccggaaag cggtatcggc tggagcgcca ggttgatgcc gaagccgata tcaacgaggt 2879281 aatcgccgtt ttccgcagac agccatacag cagcatgcgt cccttctagt gcccatccct 2879341 cttgatcgcc tgcataaacc gttcctcgaa tgagcttcac atgaaacccg gcctcacgca 2879401 agacaaaata aaggaaacca tttagatcgt agcataggcc gccgtgctga tctttgagca 2879461 gacgtcgcca tagctcttct tttgtgatct tataattctc ttttgcaagt acggcacggt 2879521 tttcgaatgg aaaacggtat gccattgctt taagaaaaag gggaagatcg ccgaagctga 2879581 catggtcttt ctcccagccg attttctgaa agcagtcttt tagaaagtca ctcattttta 2879641 tcacctaaac ttcttcttga acgtaagcag ccagcttctc cagcgcctct tgttcatctt 2879701 ctccctgggc aatcaaggta acctcagtgc ctgtgcttac cgcaaggctc atcagcccca 2879761 tgatgctttt ggcgtttact tttttcccat ccttctcaag aaacacatct gacgtaaacc 2879821 ggtttgcttc ttgtacaaac aaagcagcag gacgtgcttg cagtcctgtc tttaatcgaa 2879881 cttccacttt ctgttgaacc ataagatctc cccttttctt tacggttatt ttaaagtgac 2879941 ggtttgccct gtccgcagct gttctgcgat ttcgtcaagt tttctcagcc tgtgattgat 2880001 ccctgatttg ctgattttcc cgcttgctac catttcccct agctctttca gcgtcacttc 2880061 ctgataatca atccgcagct gcgcaatttc ccgaagtttt tcaggcagcg cctccaggcc 2880121 gattctttca tcgatgtatt taatattttc cacctgtctc agcgatgcgc cgatcgtttt 2880181 gtttaagttg gctgtttcac aattgacgag gcggttgacc gaatttctca tgtcccgaac 2880241 gattctgaca tcctcaaatc gcagaagcga attgtgagcg ccaattacgt tcagaaactc 2880301 tgtaatcttt tcagcctctt ttaaataggt aatatagcct tttttccgtt caagcgtttt 2880361 gctgtttaac tgaaactcat ttaacaggtc acataatgaa tcgttatgct ccttataaag 2880421 agagaagatt tctaaatgat acgaggaggt ttccgggtta ttgaccgaac ctcctgccaa 2880481 aaatgctcct ctcatataag aacgcttgca gcatctcttt ttgaccagct ctttcgaaat 2880541 acttcgttca aacacaaaat tctccccgag tatttttaaa tcctctaaga tcgcttttgc 2880601 attttctgaa aaacgcacaa tatagacgtt attctttttc agccgcattt tctttctgac 2880661 cagcagctcg accgacacat catattgttt tttcagcaat gtatagatgc ggcgggcaat 2880721 cgccgcgttt tcggtttgaa catcgagtac gagatggcgg tttgtaaatg ataaagctcc 2880781 attcatccga atgagtgcag acagctcggc attaatgcag cagtccttca cttccagatt 2880841 cgttaattct ttttttgttt ctgatgcaaa tgacatatag ccacctcatt tcaaggcttc 2880901 attctttcag taaatcaaca agaagagagg ccactttatg tgtatcgtga cgtattacgt 2880961 catttttata cgttacaatt tgatctctga tgacttcaag ccccatcgct ttcagctctt 2881021 cgatatcaaa atcaacagga cgcgccgatt ccatttcgta cttacgtttt atttcgtcgg 2881081 gaatgtcttc actgttcact aatatcgtat caataaaacc acagcccata tgctgattga 2881141 gcgctttcac atgatcagca gcggtgtaat ggagcgtttc gccgggctga gtcatcacgt 2881201 tgcaaatgta tacttttttc gccggcgcct ttatcacttc ttccccgatt tttgggacga 2881261 gcaaattggg aagaatgctg gtatagaggc ttcccgggcc gataataatc aaatccgctt 2881321 ccctgattac gtctattgtt tccggcagcg gatcaatctg ttcaggcgtg agaaaaacac 2881381 gcttaatgcg ctgtccgtat tctgggatcg ttgactcgcc tgagaccacg cggccatctt 2881441 ccatctcagc atgcaaaacg acactggcat tggcagccgg caaaaccttt cctcttacat 2881501 tcagcacctt gctcatttct gtgacagcgt gaaaaaaatc accggttata tttgtcatcg 2881561 ctgccaaaat caaattcccg agagaatggc ctgttaagtc attcccttta ttgaagcggt 2881621 gctgaaaaag atcttcaaca agcggctcca catcggataa agcggcaagc acatttctga 2881681 tgtctccggg aggcggaatt ttcagttcat tccgcagacg gccagagctc cccccatcat 2881741 cggcaactgt tacaatggcc gtgatgtcaa cgggtttatg ctttaggccc cgaagcaata 2881801 cagaaagacc tgtaccgccg ccaaagattg cgattttcgg cttttgtccc atcttatttc 2881861 cggcttctct tttcaatgtc ccggtgagta acatgagtat agtaatcctt tttgaaataa 2881921 tcagctaaat tctcggctaa tgtcacagag cggtgctggc cccctgtgca gccgatcgca 2881981 atgacaacct ggctttttcc ttctcttttg taagatggaa gcataaagct cagcagatca 2882041 attaatttct cattgaactt ttgcgtttca ttccacttca tgacgtaaga ggaaacctct 2882101 ttatccttgc cagtcagcgg ccgcatgctt tcgatatagt acggattcgg caaaaatctg 2882161 acatcaaaga cgagatctgc atcaattgga ataccgtatt taaaaccaaa tgacatcaca 2882221 tttacggtaa atgtctctcc ttggtttgtc gcaaagtgct tcacgatttt ttcacgcaaa 2882281 tcacgcggct tcatgtcaga cgtatcgtaa atgatttgag agcggccttt taattcctca 2882341 agcagctctc gttctagcgc gatgccttca agcggcaggc cagtcgctgc cagcggatgc 2882401 gagcgtctcg tttctttata tcttgtgacg agaatggaat ccttcgcgtc caggaataaa 2882461 attcgcggtg tgatccacgg attttcggcc atttcatcca gcgcttcaat cagccggtca 2882521 aaaaattcgc ggccgcgcaa atccatcacg agcgcaactt tgctcatttt cgaatttgat 2882581 tccttcatca gctctaaaaa cttcggaagc aatgaaggcg gaagattatc gacgcagaaa 2882641 tagccgagat cttcaaagct ttggatcgcg acagttttcc ccgctcccga cattccagtt 2882701 ataatgacaa gctgaatatc atgtgattca ctaacactca tctttctccc ccctgacttg 2882761 tctttctatt tgatgtgctg cgggtctaaa cgataactga gcagctcaaa ttccggtgta 2882821 tacgtaaatg tgccgtgcag cagcccttgt cccttcatca taaaatcaag gatatggccg 2882881 tctccagggg ccataggcag gttctgaatg tcattgacat cgtgccactg cagtttgcct 2882941 tcctctgatt ctgatacatt ttgtcctgta tatgaatcag cgacaaacgt aaacatcatc 2883001 cactcggaga caatgtggtc accgtcttta ataataaagg taaaaacgcc ttttaattga 2883061 ggatttatga tatagatacc agtctcttct ctgtactctc tgatgacgga gtctctgact 2883121 gattctccgc tctccatctt gcctcccggc gcgacccacc atccgcgtct cggcttttga 2883181 agcagaagaa ctttgtcatc cgtctgaagc acacaatttg tcactctttg caagtacgtc 2883241 acctaacctt cgtcctgtca tcgtctcttt attataccgc ttcaagatgc ctcccacaat 2883301 gaagagacat tgacaatctt ttcttctatt ttacagcata ttcattcctt aattcagatg 2883361 attttgctgt aactggaatt ctcttttatt tatggacaaa aaaaggacac ggataactgg 2883421 agaatccgtg ccaaaaaagt gtattcatta taaaaagggg gtcaattact ttattaatca 2883481 taaccgaaaa gcattacaca tgtgttacag cggaattaaa acccagtaac gtaatgtgaa 2883541 actcgtatga cagccctttt tattttaagg ttttcagcgt ttcttggagc tcttcgacat 2883601 aatgttgtac gctttgtgcc gcaatgcttc cgtctcctgt agccgttacg atttggcgca 2883661 gtgatttttc gcggatgtct ccggcagcga aaatcccttc aaccttagtt tccatgcggt 2883721 cgtttgtttc gatatagcct tcttcattcg taatgcccag gttttcaaac ggtttagaca 2883781 gaggaagcat gccgatgtaa atgaatacgc cgtctgtttt gaattcactt tcttcaccgg 2883841 ttaccgtatc gacaagcgtt acgttaccga ctttgccgtt ttcctcatga atttccttca 2883901 cagttttgtt ccataggaag tcaacttttt cattatcaaa tgctctcgct tgaagaatac 2883961 tttgagcacg gagtttatca cgtctgtgaa caatcgttac ttttgaagcg aaacgagtca 2884021 gatatacgcc ttcttcaacc gcggaatctc cgccgccaac aacgacaagt tctttgcctt 2884081 taaagaaagc gccgtcacat actgcacaat aagatacacc gcgtccgccc aattcttttt 2884141 cgccaggcac gccgattttt ttatattccg cacctgcagc aatgatgaca gcacgggctt 2884201 tatattcctt tgaaccagct ttgactactt tgtactcttt gccgtcaatg acctctttaa 2884261 tatcgccata agcgtattca gcgccgaatt ttttcgcgtg ttcaaacatt ttgttagaaa 2884321 gctcaggccc aaggatactt tcgaatccag gatagttttc tacatcttcc gtattggcca 2884381 tttgtccgcc aggaattcct ctttcaatca ttaatgtcga taaattcgct cttgatgtgt 2884441 atacagcggc cgtcatccca gcagggcccg cgccgattat aatcacgtca taaatttttt 2884501 cttctgacac actattcact ccttaaacca tcttttcaag tttgggctct ttcttataag 2884561 ataagaatcc ccatcaaacg tattccttac ccatatccta taaaatctca tggtgatacg 2884621 ctattttttt gctcaacacg attaaatgta ttcgaaaagg gtatatgtta ataaagaaag 2884681 agccttctgt ttatagaagg cccttgtcat atttattatt gaacaacacg tcttacaaca 2884741 cctttaaatg ctgctttcca gtaaggattg ctcatagagt caacagatac gccatgagat 2884801 gtattgtcgt ttaggaaagt accgtttcct aagtagattc ctacgtgtcc atttgttttg 2884861 taagtgtcaa agaacacaag gtctccgcgt ttcatttcag acgcgctgac agcttgtcct 2884921 ctgccaacta acgtatcagt tgttgttccg cctacaggtc caaggttaac acctgcagaa 2884981 gcgtatgccc agcgtacgaa tgatgagcag tcaaaaatac ggttgttgat atcagactga 2885041 gtgcgtccgc cgccaaactt gtacggagat tgtcctacaa tgcttgaacc aacgctgatc 2885101 gcgccttcaa ttccgccaga gttgctgata acagtgccgc ctgaattgct gtttgagccg 2885161 ctgctcttct tagaagatga gccgtttgac gaactgtttg atgaaccgtt agaagaattg 2885221 tctgaagaat tgtctgaaga atcatcagat gagcttgctt ttgatgattc agttgtcgcc 2885281 gtttgactgt catctgtttg tgtttcatca gatgcttttt gtgcttcttc ctgctttttg 2885341 atcaaagcag ccgctgcttc ttgttctttt ttgatgcgtg cttgttcagc ttcagtattt 2885401 gctttttgat ttgcaagttc agacgcctct gattttaatt cagaaatcgc tttagccgtt 2885461 ttcttttggc ttgcttttgc ttcgtcgaaa agcttgtctt tttcattaag ctgtttatca 2885521 aggtcttttt gcattgtttc taatttagcc aaggcagctt gaacttcttt cagcttgtca 2885581 ttcaaatccg cttcagaatc ttcgagcttc gctttatcct gctcttgctg tttgattaaa 2885641 tctttgtctg cgtccacaat agatgaaacc gcagtcgcac gagagataaa gtcaccaaag 2885701 cttgttgatc ctaaaagaac atctatgtat ccttgagatc cgccgctttc ctgtaaagaa 2885761 cgaacgcgtt ttttcaggat ttcattgcgt ttttcgatgc gtgcttcagt ttctttaatc 2885821 tcttttttca gttttttgat ttcttctttt gttttatcgt tttcttcttt tttatcttca 2885881 atcttgttgc ttgtatcaag cgccttatcg ttaatgtctt tcagttcttt ttcaatcttt 2885941 gattgatttt cctgaagctc ggttaattct ttttccttcg cttcaatgct ggaagcaacc 2886001 tcagattgct tgctttcgat tttttgtttc ttttcatcta atgtttccgc cgatgcagtt 2886061 ttacttgtaa atgggatcaa aaaactgctt gtcccgatga cggaagccaa accaagtgta 2886121 attaaactct ttctcacttt ttatatcctc ccttttactg tgaacctgtc ctcatttgga 2886181 atcgtatttt gaacatcaag tttcgttcct catactctac gaggaatgat ggttgtttat 2886241 ggttaattat tctgtgcatc tcttattctg gttgtatagc gtttatttca catcatatgt 2886301 aaaaaacact aattccttat gtacgagaat cattatacca tcaagtttcg acaaattagc 2886361 gataaatttt attacattta tgtttcaaac agatgtcaag tcacacatca tttgtcattt 2886421 ttcttaagcg tgtaaaaaaa ctgtcgatat tattttctta atataatcta tctaacaaaa 2886481 aaagagtcga ttaaataaat caactcttta aaatttacta ttctagaata tcatcaatat 2886541 atttcatata tttcgtcaaa gttgccggag agatgccgaa tcgggccgct gtgtcttttt 2886601 tcgtgtcttg cttgccatgg gcttctttcc aaatataaca gatggctgct gcccagcctt 2886661 tctcattctt caacggagca gctgcacgaa tttgctggat gacatgaaaa acccagcagc 2886721 tcatgacttc tgttttcatc tcttcttttt cagcttgctc taatagtttg accgtttgat 2886781 aagcgaaaag tgcatcctct gaaacgtcag cagccgcaga atctccattc agaagcagct 2886841 ttacaaaatg agtttcaaaa ggagcggtaa ttctctttga gcgtatcacc gcttcaagat 2886901 gctctgtttc tccctttgtg ctgctgatat aataggctgc gagtcgctgc tccacagatg 2886961 aaggaagagc ttccctccgc tcaatccaag gcgccgggcg gtcttcgccg ggatattgcg 2887021 actcgacttt tctccagatc gtctcggcaa agtcggtatg tcccgtaaaa taagcagagc 2887081 aggaaagcca gtaaaagaag gtgtcgtcac cctcaaagcc ggttttatat aatgatttga 2887141 gccatttata tccgatctcg tagcggccga caagcgccaa agtagcaccc aatttataac 2887201 gctgctccaa tagcatcgga tagacattgg agagctgatc actcaattcc gccacttttt 2887261 cgtcttctct ttcataatag tagaaaacga gaagattgca taaggcgtga agatttcctt 2887321 cattatgaga aagcacttca taagcggttt gcttcgcttt tacaacgttt cctgaataga 2887381 aataggcaag cgcgagattg ttgtatgctg accaaagctc cggatattca gttgtgattt 2887441 cctcaagcgc cgcaaccgct tcagcaagct ggccgctttc cagcaatgac tttgcccgat 2887501 cctgtttcac cagcagttca tcctgatcat acaacgaatc ctcaatgccg tcgtctccta 2887561 aatcgagcaa atcaagcaga ctatcgtttt cttcggcgaa ttcaccatcc gggtccgcat 2887621 cagaataagc ggccgcttct ttataagctt cctggaagag ccccagatgg gcaaagttat 2887681 tcgctttaaa gtaatggcac tccggcattt cggcctccag atttgccatg atatagtcaa 2887741 gaagatcgtt cgactcttga tactggccca tttccgaata aatgaccgca agctgtgaaa 2887801 gcatctctga atcctccggc tccaaatgaa ccgcgcgctg aatcagtttg cttgcccgtt 2887861 ttagattgcg ctctttatac gctttcaagc ctttatgaaa aaaatattgt ccatcttgaa 2887921 gcagctggac aatttgtgcg tgatttttat gttcagaagt gtgttttccc acaactaccc 2887981 tccgttttat acaatattac cgtcagtagt ataccataaa tcgtaagccc ctcaatagtt 2888041 caaaaggaag gattgggaaa atccctcctc ttttttattg gctgattcga ccaaaattta 2888101 cccggctttg ttttctaagt ccgcattcat tttcagctgc tgttcagcaa aatcccggta 2888161 aaggccatgg gaagccatta actcatggtg tgttccacga ccggtaattt cccctttttc 2888221 aacaaacaaa agctggtccg catctacaac ggtagatagg cggtgagcga taacaatcgt 2888281 tgtgcggccc tccatcagca cctccagcgc ctgctgaact gatttttcag attggctgtc 2888341 gagacttgag gtagcttcat cgagcataag aatgcttggg ttacggagaa gcgctctcgc 2888401 aatcgcgatt ctttgccttt gtccgcctga cagcataatg ccgcgttcgc ccacttctgt 2888461 atcaaactga ttcggcagct cctttataaa attgagcgca tatgccatct ccgcggcttt 2888521 ttcgatctca gcatccgtca catctcgttc taacccgtag caaatatttt ctctgattgt 2888581 cccggacatt aacgggcttt cctgtgatac atacccgata tgctccctcc acgattcaag 2888641 cgagtaagta tcgaccggct cgtcccccag ccgaatggtc cctgcagtcg gagaataaaa 2888701 gcgttcaagc agcttaaaca gcgtcgtttt tcccccgccg ctcggaccga cgatcgctgt 2888761 cactttccct gcttcaatga cggcgctgac ctcttttaag atcagctgat caggcttata 2888821 tccaaaagac acgcgatcaa gctggatagg cagatgtgca ttttcaattt gttttcctgt 2888881 cactgtatct tcctcttcct ctgccaaaat ctcaatcatt cgttctgttg caccgattga 2888941 tttttgcagc tgtgtgaaaa acgttgtaat ctggcccatc ggcataataa tttgaaacaa 2889001 atataaaata aaagccacga gcgctccggc tgtgagctcg cctgatgaga cctgcatgcc 2889061 gccatatccg atcactgcga caagcgctgc cattaacacg agtgaaataa gcgggccgac 2889121 aagcgattga accttggctt cacgaacgcc aagcttaaat aatgaggaaa tccccatctt 2889181 cccgcgccca tattcgacat cctccgcatt tgaagcctta acaagtctga tttccgggag 2889241 aatttgatta agcaggcctg taaaacgagc cgtttcatct tgcgtttccc gtgaaatgga 2889301 gaacattttc cgtccaatcg gcaccaaaat aagagcggcc agcggaacga ccactaacac 2889361 aagcagtgtc agcttccagt tcataataaa caagattgtc aatgatccaa tgacagaaat 2889421 gatgcctgta ataaatccgc tgatatgggt tgtaatcaat tctttgacca ccatcgtatc 2889481 gttcgttaca cggctgactg tttctccgga agcatttgta tcgaaataag agacaggcag 2889541 cttaattaat ttcttccata ataactcccg cagcccggaa atgatttttt gtccattata 2889601 gttaagcgca taggtggcat aagcgcttaa acccgcctga acgaaaaaca ccagcgcgat 2889661 caaaccgatt tgcgtgcctg acagatttga catagaaaaa ccatcgacaa gctgcttcgt 2889721 taataatgga atgagcaggc tgaccagcgt ggttactaca ctgagggcaa gcgcaaaggc 2889781 gagctttcca taagaaggat tggtccgtct tactaaggca aaaaagggtt tcaatttact 2889841 tttagatttt tgtttcttgg ttggcatata ttttcctcct gtttcagcgt tcagaaaggt 2889901 gaaaagtcat agcaaaagga tgatttttac tctttctcaa tcatatcaat ggagaaagac 2889961 tttttcagta tatttttgcc gtgatcaaaa taaaaatctc ccactcattg tttgaatagg 2890021 agatttttgt gttagacatc tttcactggc ttcttttttc tgtaagtcaa tgttacatcc 2890081 tgctgtcgca ggtcttctat tatcattttg taccgatcaa cttttgcggt atgttcttct 2890141 tttatcatct gaagggcagc ttttcgtttt tcgctattag actcaagctc tttttttatt 2890201 ttttttacaa tcaacccttt ttgccctttg atttcctctt ttaatgaaga ctcaaatttc 2890261 tttgtcaggc tgagaaagtc gttgatcggt tgattgaggg tgcccgcttt ccccttcatt 2890321 tcatcttggg taagaaacat ataggtcgtt gatacaattt ctgtttcact ttctgaaaat 2890381 aaggaagtca ctcttcatat tcctcctaag actgaaaatc aaataactga gaaatcattt 2890441 cttctttttc aaacagcttt tcaatactct cgcggatatt tttgataaaa tctctttttt 2890501 ctgttgtctg tttttttaat tcagcaacaa ttccatcatt tgcaggaagc gcacctgtgt 2890561 ggaatgattc atgaactgag attttctcca atttatcgaa tgtgtggctg aaaccagctg 2890621 caagccggaa ttgaagatcg aaggcataat gcgaagggtt ttcttccata tgatgaatag 2890681 ccgtgatgat cgcctgcttt ttgtctatga agtcttcatc gatttcctga ctgtaaacct 2890741 tctggtactt agaaatcgca tcttccatat cttcaacgat tttcataccg ttttgataga 2890801 ttctgacagc ggatgagaga ttgacttgaa tcgtttctcc cgagccactc ttccctgtaa 2890861 aataaatatc ggagccttta tagctgaagc ctttttcctt tgacaaggcg ttgagcattt 2890921 gaacgatgct gtggccgtcg acgataagtt ttagtgcgtc ttttgtttct gtgtcgagtg 2890981 ttttcaatga ggacagaatt gattttacat agtccactat ttcaccaacg tcttttaaag 2891041 cttgcataaa ttggccatgt tttagatggt ctatgaaatg ttcgtaccgt gactctatgc 2891101 ctcgcatact cgcattaata ttcgttaatt cttttttgat gactttcttt tgcgtttcat 2891161 caatataacc attttcagct aactgatcta cgaccggtcc gctgtttctc aacaaggtat 2891221 gaagaaaacc taaaaacgac ggcagttcct cttttattcg gccatacatt tgcttaacat 2891281 catcaaaatg ctcatatagg acacttactt tctttaaagc gccgtctgtg tttttcactt 2891341 tttcaatcag gtctatgtct atcccgctgg ctgcctttat aaaaccgttc aagccgtctt 2891401 tttcatagtc atccttatat ttttgaagga atttttgaat tgacctcaca tcttcgtcag 2891461 gaaccccatc cataatgttt cggatgcctt ttacacttgt atttgtatct gccatcttca 2891521 catcaccgaa tgtaataaaa tcggccttgc cgctgactcc atacagcggg tcatcttttg 2891581 agatgcgctg agtgatgttt gttgttacgc ctttgtcttc ataatatttt tggatttctt 2891641 tttttaactt ttctggcggg atggaatcta tatcttcata tttataacta aatttcctaa 2891701 taacatatct atataaactt tcatcagttt caagtaattg atcaatattg acttgagctc 2891761 catttacccc ataaacttca tcatattctc catcaatcaa ttgcaccata acttggttat 2891821 tatttgcaag tgaatgtcct aaggcgaatg tttttaaatc ctcagagtta cctgctgctt 2891881 tctttgcttt gttagtaaac tcctttgtag cctcatactg actatgatca attcctaaaa 2891941 aaagaccaaa aaagttatat gaccaatcct tattatcggc actaccttct gaaataatct 2892001 gaagctgatc aatatgtttt ttctcatcta ttatatggat tgccgttcca tcgtaacctg 2892061 attctctggt cgaactttgt atacttgtat tctgatttac aagttcattg gaggtgtaaa 2892121 tttcaatttt catattctca ggaagatcgt ggtgggtttc ctctttataa attctgcgta 2892181 tatctgcttc gaaatccttc ttagctttct taacttcact cgcaatagtt gaggcaaact 2892241 tttgtttata gtcatattct aaatcaatta accttaactt tacgttctca ttctcaaata 2892301 catttttatt tcccatctta tttctccttt ttatctatta aaaaggtgat agaattaatt 2892361 aatttctcaa ctttattttt agccttttct tcatctaagg agcatggttg attttcattt 2892421 ttgcatccaa gggtaaaggc gtattctact cctaggttat cttcctctgt agacttaaca 2892481 tatccaaaat aactgtatga ataattatat tttctatcaa tatcgtcaaa gatgtctttt 2892541 ttcttggcag tgtaaatatc cgttttcttt ttgctgcttt ttttgtattc gcctttataa 2892601 tcattttttc cactaacaat atctagcatt gtcttaggtt cattcgcaaa actttcttct 2892661 ttgtaatatg ttacatggcc atcaaacatt acattggtgt ctttatcata actattaaat 2892721 ccaatacttt ctttgttttt cccggttaac gatgatcttc ttgatagata ctttccatcc 2892781 tccggaaaca acatcctaaa ccctttcagc ttagattcca gcaaataata tcctggttcc 2892841 tcttcttttg ttgacaccat gtactctctc gttttctcgt cctgaaacgc aggtacttga 2892901 ggcagatcct tgggatcccc gctagctttt tatttttaaa aaattgtcac agtcatgtgc 2892961 caaagtcctc tttactttca attgtatagg gactgtaagc gttttaacat agagtcaaag 2893021 ggaagcatca ttctctgaac atatttctta agtgcagaaa aaggatggag gccataatat 2893081 gagtcagaaa acagacgcac ctttagaatc gtatgaagtg aacggcgcaa caattgccgt 2893141 gctgccagaa gaaatagacg gcaaaatctg ttccaaaatt attgaaaaag attgcgtgtt 2893201 ttatgtaaac atgaagccgc tgcaaattgt cgacagaagc tgccgatttt ttggatcaag 2893261 ctatgcggga agaaaagcag gaacttatga agtgacaaaa atttcacaca agccgccgat 2893321 catggtggac ccttcgaacc aaatcttttt attccctaca ctttcttcga caagacccca 2893381 atgcggctgg atttcccatg tgcatgtaaa agaattcaaa gcgactgaat tcgacgatac 2893441 ggaagtgacg ttttccaatg ggaaaacgat ggagctgccg atctcttata attcgttcga 2893501 gaaccaggta taccgaacag cgtggctcag aaccaaattc caagacagaa tcgaccaccg 2893561 cgtgccgaaa agacaggaat ttatgctgta cccgaaagaa gagcggacga agatgattta 2893621 tgattttatt ttgcgtgagc tcggggaacg gtattagaaa aataggtgta tttggaagag 2893681 aacgaaagca aggaggagca gacgtttgaa ccgatcaggc aagcatctta tcagcagcat 2893741 tatcctgtat ccccggccca gcggagaatg tatatcctca atcagcttgg acaagcaaac 2893801 acaagctaca acgtccccgc tgtacttctg ctggagggag aagtagataa agaccggctt 2893861 gaaaacgcga ttcagcaatt aatcaaccgg cacgaaatcc tccggggatc cccgggtacc 2893921 atgggcccgc ggccgcctcg agaattcatc gatacgtagc cggctagcac ccaatataaa 2893981 tctaaatacc tattactttt ttcacaaaac aaaaagagcc gtatcatccg gctctttact 2894041 cttcaatctc agaatggcgt tttttcaata cgtcaagcac atcatccagc ggcagggatt 2894101 gttctctgag caggacaagc aggtgataca gcaggtctgc cgcttcccat ttgagttcct 2894161 catgatcccg gtttttcgcg gcgatgatga cttcggatgc ttcttctccg acttttttca 2894221 aaatcttatc gacgccttca cggaagaggt acgtggtgta agctccttca ggcatttccg 2894281 cttggcgttc cgcgatcacc cgctccagtt cgttcatgat gccgaatcgg tccgcggcct 2894341 gttcttctgt ttgttccttt gtaaaacagc tgtagctgcc agtgtggcat gccgggcctg 2894401 acggttctac gagtacgagc agcgcgtctt gatcgcagtc ataccggata cctttgacgg 2894461 cttgcgtgtt ccctgaggtt tctcctttat gccataacgc ttggcgtgag cggctgtaaa 2894521 accatgtttc cttcgtttcc agcgtttttt cgtacgattc cttgttcata tacgcaagtg 2894581 tcagcacttc tttgcttgcc gcatcctgca cgatagcagg aattaatccg tcctcgttaa 2894641 aacgcagttc atctgcctgt ttcatctcac attcaccccg tactctttca agtatgattt 2894701 cacttcttta atcgatgttt ctttataatg aaaaattgag gcggccagcg cggcgtcggc 2894761 ttctcctttt gtaaaagcct caagcatatg ctgtgcgttt cccgcgcctc ccgaagcgat 2894821 aacagggacg gggacagctt cggaaacaag ctttgtcagc gtgtggtcga aacctttttt 2894881 ctcaccgtcg gagtccatgc ttgtcagcaa tatttctcct gccccgcgtt tgacgccttc 2894941 ttttgcccac gcggtgacct cccaatctgt tttctttctg ccgccgtgcg tgtagacctt 2895001 atatgtgtca gattctttgt catacttggc atcaatggca agtacgatgc attgagaacc 2895061 gaaaaactcg gctccttctg taatcagctc agggcggaga acagctgccg tgttcaccga 2895121 cactttgtcc gctccggcac gcagtatcgt tttcatatcg ctgagctgat tgatgccgcc 2895181 gccgactgta aacggaatgg caagcttcgc ggcaacctgc tccacaacgt caaccatcgt 2895241 ctttcgtcct tcgtgcgagg cggagatatc aagaaaaaca agttcatccg caccttcccg 2895301 gtcgtacact tcggcgagtt caactgggtc accggcatcc ttcaattcga gaaattgaat 2895361 tcctttgaca acgcgtcctt ctttgacatc aaggcatggg ataatccgtt ttgtgatcat 2895421 ttgcgcttca ccctttcaag cgcctcactc agcgtaaact gattggtata cagcgctttt 2895481 ccgatgatcg ctccagagac gccgtccgcc tcattgcggg cgagagcttc gagatccgcg 2895541 acggagctga ctccgccgga agcgatcacc gatttccccg tttccttagc aagctcgacc 2895601 gtgcttttaa cattggggcc tgacagcatt ccatctgtcg cgatgtcagt aaaaataaag 2895661 acttccgcac cttcattggc tagctctttg cccagttcag ttgccttaag ggttgatgtt 2895721 tcaagccatc cctctgttga aacaaaaccg tttctcgcat ccagtccgat tgcaattttc 2895781 tcgccatatt gtttcagcat ttttttgaca aacggagggt tagaaactgc tgagcttccc 2895841 aggatcaccc gctcgactcc tgctgataaa tattcataga cgtcattttc agaacggatc 2895901 ccaccgccga tttcgacttt caggttcagc ttttgcgcaa tctcaatcac atggcggtca 2895961 ttcactcttt tcccttcttt ggccccgtcg agatcaacga gatggatcca ttcggcaccc 2896021 tctttctcaa ataactcagc catgtcgtac ggtgaatcgc catatatcgt ttccttatta 2896081 taatcccctt gaacaaggcg aacacatttg ccgtttctca tatcaattgc cggatataat 2896141 gtaaaagcac tcattttttc accttctgtt ctgctgccat tttcgtaaat tgggttaaaa 2896201 tagacattcc gaccgtgctg cttttttccg gatgaaattg ggcgccgaag acgtttcttt 2896261 ttccgactac agcaggcact cgtacaccat aatcggcgct tgccagaagc gcgttctcct 2896321 ccatcccgtc aatgtaatag gaatgaacga agtaagcgta gccttgttct gttttagtca 2896381 gcagcggaga ttcattatga aaagaaagac gattccagcc catatgcgga accttcagct 2896441 tgtttccttt ttcatcttct gctttcagcc tgactgcttt tccttttaac agcccgagtc 2896501 ctgaagcggt gccgttttct tcgctttctt caaataaaag ctgcatgccg aggcagatcc 2896561 cgagaagcag ccttccctct gagaccatat cgtgaatcaa ttgatcaagc ttcgtgtagc 2896621 ccaaattgtc catcgcgtct ccaaatgaac cgactcccgg caaaatgaaa gcatcagctt 2896681 ctttcagctc ctccggcttt tcagaaacaa aatacggcac gccgacacgt tcaagcgcct 2896741 ttgagacact gtataaattc cccattccgt aatctatcac gccgatcatt tacagcatcc 2896801 ctttcgttga cggtattcct ttaactcgcg gatcgatcgt tgtcgcttca tcaagcgcac 2896861 gtcccagtgc tttaaaaacg gcttcaatca tgtggtgggt atttgttcca taatgaacga 2896921 tgacgtgcag gttcattcga gcttcgagcg ccagcttcca caaaaattca tgtacaagct 2896981 ccgtatcgaa agttccgact ttagcagccg ggaaatcagc gcgcatttct aagtgcggcc 2897041 ggttgcttaa atcaatcaca acttgagcaa gtgcctcatc catcggcaca aacgccgatc 2897101 cgtagcgttt gattcctttt ttatcgccca acgcttcgag cagcgcctgc cctaagcaga 2897161 tgccgatatc ttcagtcgtg tggtgatcat ctatatcaac atcgcctttt gcgttaatgg 2897221 aaagatcaaa ttggccgtgt ttcgtgaata aatccaacat atgtgtcata aacggcacat 2897281 ctgttttaat atccgcttgt cctccgccgt ctattgtaaa tgccagctca atatctgttt 2897341 cgtttgtttt cctgacgcgt tccgcttttc tcatttagaa atcctccgtt ctctcgcttc 2897401 aattgatctg gcatgggctt ctaacccttc cagtctggca aaagccgcga tgctttcggc 2897461 atgttcttca aaggctgatt gactgtaaga aataatgctc gatttctttt gaaaatcagt 2897521 tacgtttaat ggacttgaaa atctggctgt tccgtttgtc ggaagcacat ggttcggtcc 2897581 ggcaaaataa tcaccgacag gctcagggct gtatctgcct aagaaaattg cacccgcatg 2897641 tttgatactg ccaagcaaag cttccggaga ctgtgttatg atttctaaat gctctggcgc 2897701 gagtgtattg acagtctcaa tcgcttctac cattgtttcc gccacatata tacaaccgta 2897761 atctctcact gaagcttccg ctatttctct tcgcggcaag gtttccagct gcttattcac 2897821 ctcggctgaa accgtctcgg ccagcgccat ggaatctgtg acaaacacac atgagctaag 2897881 cttatcgtgt tccgcctgtg acagcagatc ggctgcaatt tcgctcggaa tcgctgtttc 2897941 atcagccagc acgacgattt cactcggtcc ggcaatcata tcgatatcga catcgccgaa 2898001 cacttctcgt ttggcaagcg cgacataaat gttgcccgga cccgtgattt tatccaccgg 2898061 ctcaatggtt tctgttccgt atgctaacgc cgcaatcgcc tgagcgccgc ccattttgta 2898121 aatgtctttt atgcccagct cggctgcagc aaccaaaact ccaggagaca gcagaccgtc 2898181 ttttcccgga ggcgtgacga gaacgattct ttcaacgccc gctacgagcg ccggaatcac 2898241 attcatcaaa acagatgaag gatatgcggc cgttcccccc ggcacatata caccggcgga 2898301 atccagcgcc gtcactttct gccccagcat tgtgccgtcc tttctgtgat aaaaccagga 2898361 ggattgcagc tgtctttcgt gatattccct aatattttcg attgcctgcc taatcacctg 2898421 aagaagacgt gaatccagtg aggtgtatgc ctcctcaaat tcttcttttg tgaccagcgg 2898481 gctgtctatt tcgatgcagt caaatttcgc cgtgtagctg cgaaccgcct gatcaccgtt 2898541 tgctttaaca tcttcaataa tggaccggac cgtctttctt tgctcttccg ttccggcatc 2898601 gatggaacgc ttgagagaaa gccgttccgc tccgctgatg gttttgatct tcattttgcc 2898661 gtctctcctt ccacaacgag agataggcgg gatgccattt cgtcaatcac atcgtctttc 2898721 atgcgatagc ttaccgggtt gacaataaag cgagaggtaa tgtcacaaat gtgctccgtt 2898781 tcaacaagcc cattttcttt cagcgtctgt cctgtggaaa caatgtccac tatccgatct 2898841 gcaagcccaa tgagcggagc cagttcaatt gaaccgttga gcttaataat ctcgacttgt 2898901 tctccctgct ctctgaaata actggaagcc acattcggat actttgtcgc gattcttggc 2898961 gctactccgc tccagtctgt attcggaagt ccggcgacag ctaagtggca tttgctgatg 2899021 tttaaatcca gtacctcata cacatcgcgt tcctcctcca gcatgacatc cttgcccgca 2899081 attccgacgt ctgccacgcc atgctccaca tacgtggtta cgtccatcgg cttcgctaat 2899141 ataaaccgaa gattttcctc cggcacatcg atgatcagtt ttctcgaatc ttcaaactcc 2899201 tcagggagcc tgtagcctgc ctgcctcagc agccctgccg cttcttcaaa tatccggccc 2899261 tttggcatcg ccattgtgag taacttaccc attttgctct tcctttctgg caccgataaa 2899321 ataagtgacg tttgcaaaag attttgtcat ctggtcgata ttttctattc ccgataaatc 2899381 ttgaagaacc actttgttcc ctttcatgcg ttcttcattc gcataagcga tggcttgcgc 2899441 ccgctgctct ttgctgaaaa taacagcgtc tatttcacaa ggttcgtcct tcatatgaag 2899501 ggcttcaatc agccggtcga tccgaagccc gaagcctgtt gccggtgcag gtgaatcaaa 2899561 atggcccagc agcttgttgt aacggccgcc gcttccaatg acaaaaccga cattctcggc 2899621 gtacacttca aataaaatcc ctgtgtaata gctcatgtgg ctgaccatat tcagatccag 2899681 gcggacattt tccgtacatc cgtaatcctc aagaatgtcc cacagcgcct tcagctcatc 2899741 aaccacgctt tttccttgcg cagaatcgac gatttcctcg gcacgtccgc atacttctat 2899801 accgccccgc agttcaagga gctcaagcag cctgctttta tcaatggagg aaagcgggag 2899861 agacttgaca tgctctctgt agccgacgta gttcttttca tataagaacc tccgcagcac 2899921 atcagctcgt tcaacgtttc cgagcacctc aacaaacaaa gcatccgcaa tgccggcatg 2899981 gccaattgca attttaaagg atgccagccc agcgtttttt aatgccccga cgactaaagc 2900041 aatgacctcc gcatccgcgc tcgtcgtgcc gtcaccgatt aactccactc cgacctgctc 2900101 gaactcagcc ggacgtccgc cttcacgctc ctgagccctg aatacatttg ccgcatagcc 2900161 gactcttagc ggatgaccgt gtttcagaag cttcgatgcc gccacccttg caatcggccc 2900221 cgtcatatcc gggcgaagca ccaatgtctt gccgtcctga tcaagtagct taaacagctg 2900281 ctgctcttca attgctgact ggacgccaac ggtatcgtaa aactccagtg tcggcgtttc 2900341 cataaattga tatccccatt tatcaatcaa atcggttaac gatcgtctca cctttttttt 2900401 cgtttcgtat aaaccgggca gtgtatctct catgccgtgc ggtttttcaa acataaacat 2900461 caacccgagc acctccgctg ttatcttatg aaggaaaatt ccgaatcctt tagttcgcta 2900521 atatgataat atgttagcag atgaaagaat gaaaatcaac gcttaacttc agtaaggata 2900581 tttttagttc aaatatcctt ctcctcatta tgaaaaaatc atgaataatg tattaaaggt 2900641 acgtaatatc tcaaattctt tatgtttggc atgctataat acaaatcaaa tagagaacaa 2900701 ggagataaag atgaaaacac tgcgaactct atgtgtcctg atgattcttt caggcgttat 2900761 ttttttcgga cttaaaatag atgcaaaaga tatagatatt ccttttttga acagccttaa 2900821 aaaagtggtt tctgatagcg atacagactc agctgcgaat agcaaaaagg agctgaaggg 2900881 aagcgcaaaa ccgctggatg tcatccttta caatcaaatg gacgcacccc ggctctataa 2900941 cggctgtgaa gtaacaagcc ttgcgatggt gctgaattat gcgggatacg acgtgacaaa 2901001 aaataccctg gcaaatcagg ttgccacagt gcctttgaca tacagcagcg gattaaaggg 2901061 tgatccgaat gacggatttg tcggggatat ggcgaatggc cctggtctcg gtgtctacca 2901121 tcgaccgatc tatcagctgg cgaaaaccta tgcgggagac aaagtgtctg atctgactgg 2901181 aaaaagtatt tccgctgttt atcagcagct tgaaaaaggc aatccagttt gggttattac 2901241 gacagccaac tttacgccag ttgacaacat gcagacatgg aaaacgccaa acggaacgat 2901301 agaaattacg tacagcgaac acagcgtcgc cgttacggga tatgatgata aatatgtgta 2901361 tctcaatgat ccgtatggct ataaaaacag aaaaaccgat agaacaagct ttgaaaaagc 2901421 gtggaaacaa atgggcagcc aggccgtggt tattcaaaag taaacacctg aagcctcact 2901481 atgctctatt ctgagcaaat acgacaatat tcatgctttt tgtatcaatc ggtaagatcg 2901541 attcattttc catttttcac ccaaaattgt ctttactttc aggctgtctg tttttatgat 2901601 taaagcagat tcagccttgc cccgatctat gcgagagaag ccggtgcaag tcgctgacgc 2901661 ttctcttgca aaaaatgaaa gatatccggg gaggatttat cattgaaaaa aatcgtgtct 2901721 atcctattta tgttcggttt ggttatgggt ttcagccagt ttcagccatc aaccgttttt 2901781 gcagctgaca aagtggtgca cgaaacaatt atcgtaccaa aaaatacaac atatgacggg 2901841 aaaggacagc ggtttgtggc agggaaagaa ttaggtgacg gaagccagtc agaaaaccaa 2901901 gaccctgttt ttcgtgtgga ggatggagca accctgaaaa atgtggtgct tggtgcacct 2901961 gcagctgatg gcgtgcacac ttatggaaac gttaacattc agaatgtgaa atgggaagat 2902021 gttggtgagg atgcgttaac ggtgaagaag gaaggaaaag tgacgatcga cggcggttct 2902081 gctcaaaaag cgtcagataa gatattccaa atcaataaag ccagtacctt cacagtgaaa 2902141 aatttcacgg cggataatgg cgggaagttc attagacagc ttggtggttc aaccttccac 2902201 gttgatgtga tcatcgacaa gtgcaccatc acaaacatga aggaagcgat attccggacg 2902261 gacagcaaaa caagcacggt cagaatgaca aatacacgct actctaatgt cggtcaaaaa 2902321 tggattggtg ttcagcatat ttacgaaaac aacaacactc aattttaaca aaaaaagtcc 2902381 gctgatgtta ttcagcggac tttttcaatc tttcttgcat ttcttccttc gtatagatga 2902441 tcctcatcgg atttccgccg acaaatgccc cgtcaggcac atccttatgg acaagcgttc 2902501 cggcggacac aactgcgcca tctcctattt tcaccccggg cagaatggtc gtgttggcac 2902561 caatcatcac ttcgtccccg atcagaactt tgccgatccg gtattcgtga atcaaatact 2902621 catgggccag aatggtcgta ttgtacccga tgattgtatt tgttccgact gagatctttt 2902681 ccggaaacat gatatctggc atcaccatga gggcaaagga tgtctgtttt ccaaccttca 2902741 tccgcagaaa tgtgcggtac agccagtttt tcatccctat aaacggcgta tatctcgcaa 2902801 tttgaatgac aatgaaattt ttgacgacct ttaaaaaagg taccgtttga tagacatgcc 2902861 acagtgagtt ggcccccgag accggatgac gatctgtttt tctcacagat tacttcactc 2902921 caacgatttg taatagatca ctcattttct caagcataaa atccggctca tgcttcgcca 2902981 gcatttccgg ccctttaatc gtccatgcga ctcctgccgt ttttgtaccg gcgtttttcc 2903041 ctgccagcac atcatggtaa ttatcaccga ccataatggc ttccgccggc tcgcttccta 2903101 gctgtttcag cgctaacagc acaggctcgg gatcaggctt tgcattcgtc acatcatcaa 2903161 gggtgacaac tgtttcaaag aattcgccga ttcccgtgag cttgaggccc atattgacag 2903221 tatctcttaa ttttgttgtc acaattccta atgtaaagcc ggcttttttt aatgcatcca 2903281 gggtctcata taccgtttca tattcagtga cgagtgaatc atgcatgtca tgattgtacg 2903341 ctctgtacat agcgatcata tcctcgcatt tatcagggtc catcgaagag aacgtatcaa 2903401 aaagagacgg cccgataaat gcaaggacat cttctcgttt atacttgctc ggataataat 2903461 gctccagtgt atgcaaaaag gacgcgataa ttaattcatt cgtattaata agcgttccgt 2903521 ctaaatcaaa cagaatcgtc gttacttgtt tgtcactcat attgcttcct ttccaaccgc 2903581 tgagggtttc cattttttcc acgtgtgcgc aatagccatt gtcagcagaa ctgctgtggt 2903641 gacacgaatc aaaagaagcg gccagaccgg tatgccaagc ggaataaaga caagtgtatc 2903701 ttccacgacc gcgtggcagg caacgagaaa tataaatgcc aatgtcatgt cccgcttgct 2903761 cacgccgtca tcctcgacag ctttgatcat gacacccgct ccgtaggcca gaccaatcgt 2903821 cagtcccgtc accatcgtca tagacgtatt tttattcatg ccaagcagct gcgtaaacgg 2903881 cgacagccac ctggaaaacc gataaagcca gcctaaatct cttaaaaact ggatgataat 2903941 catcagcggg atcactattg ccgccagctg caaaacacca agtccggctt tcgttaatgc 2904001 ttctgccaac attcctagcc agctgtctgg cgccgcgctc ttcgcagcga taaaaccgta 2904061 ctgcgccgtt tcctttccgc catgccaaat gaggttgatg acgatggctg acacagcggc 2904121 caaaccgatg cgcacggcca atatgacgcc aattctgata ccaacctttg cggcaactgt 2904181 cgattcgata atcaagttat gacagaaaga aagcataaca gctaaaataa agacttcttt 2904241 cacagataaa tccaatgtta aaatcccggc aattcccgca tacagattca gcatatttcc 2904301 cagtacaagc ggaatggccg cttcaccaga aagcccgaag agacccatta ccggtgtgat 2904361 cagccgtaca agccaatcca tgacaggggt atgctggagc aaagtgacca atagcgttac 2904421 cgggaaaatc actttaccca gcgtccatgt tgtttgaaaa cctgctgcaa gaccggccag 2904481 aaagatcttc ttcatccctc atcccccttt gttgacgtct actccgcgta ccgctccttc 2904541 gagtatccct tgacgcgtct gaagatgatg gctgccacag ccaaaacaat caatacgatt 2904601 gaaatcacct gagcgatgcg aagtgaatca gtcagcatta agctgtcagt ccgcattcct 2904661 tcaataaagt atcttccgat tgaataccaa atgatataga tcaagaacat ctcgcctcta 2904721 cgcaaattcg ctctgcgcag cagcagtaaa acaatgacgc cgacaaagct ccatagtgat 2904781 tcatataaaa aagtaggatg ataatattgc ccattgatat acatttgatt gatgataaat 2904841 tcaggcaggt gcaggttttc taaaaaggct ctgctgacag cctcgccgtg cgcttcctga 2904901 ttcatgaagt tcccccagcg gccgatcgcc tggccgagca aaatgctggg cgcggcaata 2904961 tccgcaagct tccagaacga aaggtttttc actctcgaaa acacataacc cgttaaaatg 2905021 gcgccgatta atccgccatg aatggcaatg ccgcccttcc aaatcttaat gatttctccc 2905081 ggatgtgccg cataatagtc ccattcaaag gcaacataat aaattcgtgc gcaaataatc 2905141 gcaattggaa tggcaaacag gacaagatca ataaacgtat ctttctgcag cccccgtttt 2905201 tcactttccc tcatcgctat ccacagcccg agcaaagcgc cgagaccgat aatgattccg 2905261 taccagtgga cggctaacgg ccccagctga aatgctatcg gattgagtgg ttctatcgct 2905321 tcattcattt aacgccaact cctattcttc ttgttcaccg tcttcaatga cgtccgccag 2905381 cttgttggta aattgttcag cggcattcag ccccatccgc ttcaatctga agttcattgc 2905441 tgccacttcg atgatgactg caagatttcg gcctgggcgg acgggaatcg tcagttttgt 2905501 aatttctgta tcaatgattt tcatggtctc ttcctcaagt ccgagccggt cgtattgctt 2905561 gccctgctcc cagagttcaa gattcatgac aatcgtgatt cgtttattgc ttctgaccgc 2905621 gccagcgcca aatagcgtca tcacattgat aatgccaagg cccctgatct caagaaggtg 2905681 ctcaattaat tccggagcgt ttcccacaag agtatcctga tcctcctgcc gtatttcaac 2905741 gcaatcatcg gcaacaaggc gatgccctct tttcacaagc tctagcgctg tttcgctttt 2905801 tccgacgccg ctttttcctg tgatcagcac gccgacacca tatatatcga caagaacgcc 2905861 atgaattgct gtggtaggcg ccagcctgct ctcaaggaag ttggttaaac ggcttgacag 2905921 tcttgtcgtt ttcagcggcg atctgaggac aggcacccca tttttctcgg aggcgtcaat 2905981 cagctcctgc gggatgggca tatctctaga aagaataata gctggtgtta catcagtgca 2906041 cagagaatcc attcgctgct ttttctcctc ttcaggaagc tgttcaaaga aagaaagctc 2906101 tgtttttccg agaagctgca cgcgctccct cgggtaatat gtaaaatatc cggcaatttc 2906161 aatacctggt cttgataggt cactcattgt aatcgggcgg ttaattcctt cttctccgct 2906221 gattaattcc aaattgaact gttccattac gtcttttgtg cgaacctttg ccacgatatg 2906281 ttcctcctgt tccgggctgc cccgagcttg ctcacaatac tttcatttta tcactttcgg 2906341 gcttgaacct aaaacagatt ttataaaagg ggggaaaaca cctcagctgg tctagatcac 2906401 tagtctgaaa aagagtaaaa taaaggtatt caaattccag aaaggcggat catctatggc 2906461 agagagtctt cttatcaaag acattgcgat cgtgacagaa aatgaagtaa tcaaaaacgg 2906521 ctatgtcgga atcaatgacg gaaaaatcag cacagtttca acagaacggc ccaaggagcc 2906581 atattcaaaa gagattcaag cacctgcgga ttccgttttg cttcccggca tgattgacat 2906641 tcatatccac ggcggctatg gcgcagatac aatggatgct agcttttcca cgctcgacat 2906701 catgtcgtca agactgcccg aagaaggcac gacgagcttt ttagccacaa cgattaccca 2906761 agagcatggg aacatttctc aagctttggt gaacgcaaga gagtggaaag cggctgaaga 2906821 gtcctcttta ttaggtgcag aactgctcgg cattcattta gagggcccct ttgtttcgcc 2906881 taaaagagcc ggagcgcagc caaaggagtg gattaggcct tcggatgttg agcttttcaa 2906941 aaagtggcag caggaggcgg gcggactgat caaaattgtt acacttgcgc cggaggagga 2907001 tcagcatttt gaactgatcc gccatttgaa agacgaatcg attatcgcat ccatggggca 2907061 cacggatgcc gattccgcat tgctgtcgga tgccgcaaaa gcaggggcga gccatatgac 2907121 tcatctgtac aacgcgatga gcccgtttca tcaccgagag cccggagtga tcggaacggc 2907181 gctggcccat gatgggtttg tgacagagct tatcgccgat ggcattcact cccatccttt 2907241 agctgcaaag cttgcttttt tggcgaaagg cagcagcaag ctcattttaa ttaccgattc 2907301 catgagggca aaaggactga aagacggcgt atatgagttc ggcggccaaa gtgtgacggt 2907361 aagaggacga acagcacttc tttcagacgg aacccttgcc ggttcgatcc tcaaaatgaa 2907421 cgaaggcgca cggcatatgc gtgagtttac aaattgctct tggacggata tagctaatat 2907481 aacttctgaa aacgcggcca aacagctggg catctttgac cgaaaaggca gtgtgactgt 2907541 gggaaaagat gcagatttgg tgattgtcag cagtgattgc gaggtgattc tcaccatttg 2907601 ccgcggaaac attgcattta tatccaagga ggctgaccag atatgaaagt aatggaatgt 2907661 caaacgtatg aagagctaag ccaaatagca gccagaataa cggcagatac aatcaaagaa 2907721 aaacctgatg ctgttctcgg tttagcgacg ggcggcacac cggaaggcac gtatcgccag 2907781 ctgatccgcc tgcaccaaac tgagaatctc tcatttcaaa acatcactac agttaatttg 2907841 gatgagtacg ccggactttc aagcgatgac ccgaacagct atcacttcta tatgaacgac 2907901 cgtttttttc agcatatcga cagcaagcct agccggcatt ttattccgaa tggaaatgca 2907961 gacgatttgg aggccgaatg cagacggtat gaacagctag tcgattccct cggcgacact 2908021 gacattcagc ttctcggcat cggccgaaac ggacacatcg gctttaacga accgggaacg 2908081 tctttcaagt cgcgaactca tgttgtgaca ttaaatgagc aaacccgcca agcgaatgcc 2908141 agatattttc cctccataga cagcgtgccg aaaaaagcac tgacaatggg aattcaaacg 2908201 atactctcaa gcaagcgcat tctgctgctt atttctggaa aaagcaaagc ggaagctgtt 2908261 cgtaagctgt tagaaggaaa cataagcgaa gattttcccg catctgcttt gcacctgcat 2908321 tccgatgtta cggttttgat tgatcgtgaa gccgcgtcat taagaccttg aaaggaacat 2908381 gctgacttat gaatatcaat aaacaatcgc ctattccgat ttactatcag attatggagc 2908441 aattaaaaac ccaaattaag aacggagagc tgcagccgga tatgcctctt ccttctgagc 2908501 gcgaatatgc cgaacaattc gggatcagcc ggatgacagt tcgccaggcg ctttctaatt 2908561 tagttaatga aggcttgctc tatcgcctga aagggcgggg cacctttgtc agcaagccaa 2908621 aaatggaaca agcacttcaa gggctgacaa gctttaccga ggatatgaaa agccgcggga 2908681 tgacaccggg cagcaggctc attgattatc agcttattga ttcaactgag gagctcgcgg 2908741 ctatattagg ctgcgggcac ccctcctcta tccataaaat cactcgggtg cggctggcaa 2908801 atgatattcc gatggcgatt gagtcctcac atattccgtt tgagcttgcg ggtgaattga 2908861 acgaatcgca ttttcagtcg tcgatctatg atcatattga aaggtacaac agcataccga 2908921 tttcccgtgc aaaacaggag cttgagccaa gcgctgccac cacggaagaa gcgaatattc 2908981 ttggtattca aaagggagcg cctgtcctat taattaaacg aacaacatat ctgcagaacg 2909041 gaactgcttt tgagcatgca aaatccgtat acagaggcga ccgttataca tttgtccact 2909101 atatggatcg tctttcataa aaaaagcctc caaccctttt taaggattgg agacatggcg 2909161 aaaatcaaac tggtctggtg ccggacgata tgtttctttt ttcgtcttga acttccagat 2909221 cggtgatttc gttttgccgt taaaactgtc ttccactata atgtaccaat aataaacaga 2909281 ctgcggttca agatgatccc agcggaattc agctgtgtcc ccgctcttca cttgctcccg 2909341 ttttccgagc tcttcattgg tatatacgtt acattcaaaa taatcggttt ccaccttttt 2909401 gattcttggc ttcaaatcaa gcgaaaggga aaattcatcc ttgttgccat aggtatccgt 2909461 atcatagtag ttcttatcct ttacatacgg agagtacgtc gatacgtgca ccatgtcatt 2909521 ggcttggtca aattgaagca aacgcaaata cccttggccg ccttctggcc cgccctgata 2909581 atcggccagc atttgatgca caagacgatc cggtttccca tcaccatcat catccagctc 2909641 atctgttttt ctcatcgcac tatgataatg cccgctcaac accatcacga cattcgggtt 2909701 cggctttacg atttctttga atattttctc tccgattggg cttctgtttc cgctgaccag 2909761 caaatactca tgaaaagcta aaatggccat ccggtcagga tgcttcttca gcacctgatt 2909821 catccacgcg atgtcttcat ccgtaatgcc ccatcccatg tacagcatga tataatcatt 2909881 gccgttgcta gaaatcaggt cataatgtcc gcggttattt ttataggaac cgccataatg 2909941 aaatttttta tcaaaacgat cgctgccaaa atatttgcca aacgccctgt aggagccgtc 2910001 cttatgtccg acatcgtgat tgccggccag cacgccgtaa ggaattccgc tcttatccag 2910061 aacggacatt gaccgatcag cgtttttcca ctgtctgata tcggcggaat catctacaat 2910121 atcacccgtg tggaacacat atttgatatt gagctgcttt tgattatctt ttatccattc 2910181 ggtctgttta tcaaaaatat gcggatagct ttcggcgtaa tactgtgtat cagacatcca 2910241 gacaaatgtg tacatatcct tcgcaggagg aatttcatcc tgtacaatca cattcatttt 2910301 cgactcccgt acaaaatcgg cggcaatcac agacgctttc agcgtaaacg gtttgtcatc 2910361 cttcgcgacg aagctgtcaa caggctgcca ttcgtttgtc cgataattcc aagcatacat 2910421 cgtcaccttt ctccccggca aagaactgcc cttccagact gattctgcca gatcattctc 2910481 atcaattgat ggatcaaccg tcacttcaaa gcgatgataa gggaaaagct ctttgttttc 2910541 tgtcgatact gtttttccat cagcagctga tacccgctcc aattctttat tcgtaaatgg 2910601 ggtctccctt tccggcacaa agcttttcgg cggttcagtc agtgacgcgt gcttaaatat 2910661 tttcacatga ttgcgcgctg tatattgaaa tcccctataa aaaccaacat ccatggcatc 2910721 attcgtcgga tctttcaccc gtacagaaag cttggcctta tgcgtgtcgg cttcgctgtc 2910781 tataacctcc ggctggtccg gatgctctcg ttcggtttta aatatcctct caatcactgt 2910841 tttattgccc gcgagatccg ttgctgtcac ttttagagaa tgttttcccg gcaaaaggtc 2910901 agaagatgac gtatgatatg ggagtgtaat gctttctcca tctaacgacg cctccgcttc 2910961 ctcaattctg ctccatttat catacatatc cgcctgcagg ataaggtttc ctttatacgt 2911021 ttgcccctcg gtgatattcg gctcaatgtg aggtcctgaa ttatctaccc gtacaaccag 2911081 gctgacattt tccttcccgt cgcttgcttg aatatggtga gcgccttcag aaagctttga 2911141 tgtatcccac tccagcagct gtgatgtaaa tagtccgtca ggcagattga actgaaattg 2911201 ccagctttta ttcgagcgct gattatcgcc aataaagagt tccttctcag gagacaccct 2911261 ctgatctctg atcaccgttc catccgataa caccaatcgg gcgtttttga ctaagaagtc 2911321 atcacggttt tcagccgtat caaacggaga caccttcgaa cctgaacgta tcgtaatacg 2911381 ctgcagctgc ttccctttcc gaagcagtgt ctctggcaat ggaacagaat aggtgcggta 2911441 tttatttgtt gtatcatcga acaccttcag cactttgcct tccatcgtta ccgcgttttt 2911501 aaaataaagg ttcgttttcc tcgtatcgaa tgcaaaatat acttcttttt ccatcgcggg 2911561 ctctgtcact tgttttttcc cgtcaatcca tagcttaatg ctgtcagctc gcccttctgt 2911621 cgtggctttg agaaattgag ttcccgacag cgtgtctctg ttttcaatat tcatccgcag 2911681 accgtgcgcc ttgcttgttt gtttaatatc aatcattttg accggcgttc tcgcttcatt 2911741 gatcccgtcc ccggccgcca cataatactc tagctgatcc ttcccgatca attcaggcga 2911801 atacacaata taatggaaga gattatcgtt gcggtctttt tcagcaagaa ttcgcttaaa 2911861 cggtttgttc tcatccgtcc ggtagtaaaa ggccactgtt ttcactaggc ttcggtcccg 2911921 tatgtcagcc cgcagctcaa tgctttcagc agggcggaca ggcttgcggt cagtcaaatc 2911981 ctcaatgacc ggcttttctt tatcgagctt gattttccgt ttctggtcgg gcacctgtgc 2912041 ctgtaatacg gttccgggag acggattctt ttccccgatt gaaatgttca gaagttctgc 2912101 tgttccgttc agtggatact tataaagcac tgatgacagc cggcgcagcg catgtttccg 2912161 ataatgcgca accgaaatgt cctttcctgt attcgttgat atcacaacgg cccgcggcct 2912221 cgtattggcc ataccctctg tctcgtctat caccgcaaga ttttttcctt cttttagttg 2912281 tgtctgataa taacgattga aatccgctga cgtcaattct ggatgcccgg caggcttcag 2912341 ccagacgaca aacgtttcgc cggatggtat caagatcctt tcatcaggtc tccaaatcag 2912401 atcggagtca ggcccttctt ttgggtagcg gtaacggata tggtagtctt taaaatcaat 2912461 cgttctgtca gtcgtattaa aaatctcaat aaattcataa ccgtctgcgc gtcctatatt 2912521 cttcgtatca accgccagct ctgtgatcag aagctccgga atatgggcaa ggtcagcctg 2912581 gtatccttca agcttcagtt tcttcgtctc cgactcaacc cgctgcttcc cattcgacat 2912641 cacaatgtaa tactcaagct cgctgttcca aatcaaacgt ttcggaattt gtgccaaaaa 2912701 cttgcggacc gctccggggg tcgggtccat cggcaccatt ttgtagccca gctcattact 2912761 ttgtttataa aaaagaaagg cggaaaatgc ttgatacgaa ttatcgcgaa cttgagcctc 2912821 aatcattaga ttgcttctca tttcagcttt cacatcaatt tgaggaggat tttcaagcaa 2912881 gggtatgtaa tgaggcgttt gaaatagttc ctgctgtaca acaggaaaag ctttcgattc 2912941 atgatggccg ccagacaaaa cggaaagaaa agacagtaat atagaagcaa taaccgtgta 2913001 tttcctcatc aaagcacctc ccttttcatg tattttgcgt ctgaacaggg aagcttatga 2913061 gttcattttt gtgcataaag aacaaaaaaa cgtctgtctc ttgaaaattc cactattacc 2913121 cagtaaacta aggatagtta accagttaac aattaaatca gagaggcaaa ttgatggaca 2913181 acagcattca tgatgaatta tttcaagcta tacaacaatt cgcattaaaa agggataaac 2913241 gcgtctggca aaaggtgcag ataccatcca ttggcatatc ctcacaacat cacgatcacc 2913301 tcaaaaaaga ctggactttg acccagcttc acattgtttc ctgcatacat accagccaaa 2913361 atgtgaacaa cagcttctta gcatcccgtt tacacatctc aaaagccgct gtttcaaaag 2913421 cggttcatgc tttgttgaaa cacaatatca ttacagtgac aaaaaagcct ggcaacaaaa 2913481 aagaaatttt ttatacgcta actgatagcg gcagaaaatt ggcggcatta catgaacagc 2913541 ttcatgagaa agcaaaggag caatataaac agcttttcaa tgaattttca attgatgatt 2913601 taaaaacagt gactgcgttt ttcaacttgt ggatcaaata tatgtaaaaa gagtctcacc 2913661 cgcatgggag agacctttgg aattctatta tgccccgtca aacgcaacga gaagtgaaac 2913721 aggtccgcgt gtatacagac cggactcagc ataacaaaaa tcttcctcta atctgatatt 2913781 ccgcatctta tccagcacaa tattagctac aatttcgatt tcgtttttgg caaaagctgc 2913841 tcctacacag ttatgaatgc cggatccgaa agcgagatgc cgggcggcgc cgctaaaagc 2913901 gctcttgata ccaagatctt cccgatgaat attaaacacg tcaggctgtt caaatgcttc 2913961 agggtcccgg ttagccgcac cgatcataca aaaaacaatc gtatcttttt tgatttccat 2914021 accgccgacc actgtatctt gggacagctg ccgcggaatc agctgaaccg gcggtttata 2914081 acgcaatgtc tccgcaatgg ctctcggaac taacgaacgg tcagccaaaa catcattcat 2914141 ctgctcagga ttgttgagca aatggtagat catcagtgcc agcgtcttat cagccggttc 2914201 cgttgcggct aacagcacat taagaatcag tgcgagtata tccttgtccg acagcgccat 2914261 gccttcatat tcagaagtac ataggatcga aattaaatct gatcccggat tgacgcgacg 2914321 ttctttaatg accggcatca agtattggga aagctgttcg ctgcaccata acgaatgtgc 2914381 ccgcgcttca ggagattgag agatactcgt gataaaatcg gcaactccgc tgtgccactc 2914441 agagattttt tcatggtctc ttttatccag cccgagcatg tccatcgtga cgcacaccgc 2914501 aaacgtcttt ccaaaatcat tgacgagatc acttttccct ctttcaagat aaggcgctaa 2914561 caagttttct gcattttgtt taatcaatgg agacagatga tccagtgcgt caccgataaa 2914621 gcttctcact acaattcttc ttttggcaga gtgttctttt ccatgcattt gggccagcac 2914681 agggcctcgc atgactggtt cggcacgctc aacaagtgat ttcgtcgtga agatatccgg 2914741 atgctgaagg atatagcgga catcatgata gcggctgata aaataactgt ctatcgactc 2914801 ttcataatga accggatctt cctcccgcag ttgtgaaaaa taagcatatg gattgttttg 2914861 aaattgatca gaaagcacac taaacaattt aatcgattgg ctcatgtttt actcccccta 2914921 tcatccttca gatgtgatcc gtttctcaga aagcatctgc gccatttcct gtacaatgag 2914981 atacccttga ttcggccgca tacaaataga aaattcatgg ttactgatct tctcacccag 2915041 cttccacgga cgatgataag caaggagtgt ctcttccacc tctaaaatat ccggagctcc 2915101 gataaaaaac ggcagctcag ctatgacata ttccacagcc aaattcagca tatcctcact 2915161 gacttcttcc atcatcaaac tgacgccccg cgcacgcccg attatcgctt cacgagacat 2915221 gtccaaacaa gcatgtcgaa aatgaggctg ctcaaaaaat gcatgttcaa cttcttgtct 2915281 caacagctgg taggctttgt tatctataaa atcagaaaat gtatgaatcg ccttcggatc 2915341 cccgccatga gccacaaggg ctctttctgc aaatctcctg tttcgtgata cctctttcct 2915401 tacttttcgt tcagcctttc ctctcggagt tccaagcgct tctagaagat tagccgcctc 2915461 atgccctgca agtaaaactg aaacgctttt aaattgagct ttcgcccatc caattaatct 2915521 gtaaatataa tcctctgaaa acctgctgtt aaatgggctg atccccacca aaacatgcct 2915581 gcgccgttca aatatttctc tgcagttttc tgttaatgcc tcagcaataa aatgcacaga 2915641 ccttctttcc gttaccattc cggtcatctc attcacccct aaaacttatc ccgctttaag 2915701 tcatcaccct caaatacaag atggaatagc tagaacaact gaacaagacg aatggcaggc 2915761 atcacttaaa gtttccaaat gttttttaag attttaataa tcattttcaa tacccatatc 2915821 atgataaatg tttactagta aacattagtc attttatccc ttttccttcc aaacgtcaat 2915881 atgatctgtg cccaaatatt tgaaaataaa tgtaaacatc acattttcca cacacttttt 2915941 acacgcatat tcagcatgac atatcaacaa atagtctaaa caccaacaat tgacaacgaa 2916001 aacaagaaaa gataaaataa aattgttcac cagtaaacga tttgttttat tgtttcatcg 2916061 taaactatta ttcctaagaa agaaggtagc ctatgtctga tttgacaaaa cagatgatat 2916121 acgacatata cgtgagactg ctgcacctta atgaacaaaa agcgaacact tcacttcagc 2916181 aattttttaa ggaggccgca gaagaggatg tagctgaaat tcccaaaaat atgacaagca 2916241 ttcacgtcat tgactgcatc ggccagcatg aacccattaa taatgccgga attgccagaa 2916301 aaatgaactt atcgaaagcg aatgtaacga aaatcagcac aaaactgatc aaggaagaat 2916361 tcattaacag ctatcagctg acagataaca aaaaagaagt ttattttaaa ttaacccgta 2916421 aaggcagacg gattttcgac ttacatgaga aactgcataa aaaaaaggag ctggcttttt 2916481 accaattcct cgattcattt tcacaagaag aacaaaaggc tgtattgaag tttctagagc 2916541 agttgacgtc aacacttgaa gcagaacaaa ccgatgggac tccagacaaa cctgtaaagt 2916601 aaacaaaaag gcggtgtaca ctttggctca tacaaaatca aaggcagtat tgatcttata 2916661 cactgtttgc ttcagtgcat tttttgcatc tttaagccag aacatttatt cacctattct 2916721 tccgatcatt aaagaatcat tccatgtttc cacagctatg gtgaacctgt cagtctcagt 2916781 ttttatgatt gtgacagcaa taatgcaaat tatattagga gcgatcattg attttaaagg 2916841 cgctcggatc gtcttgatta ccggtattct ggcaacggca gcagccagca tcggctgtgc 2916901 ggtgactact gactttacct tgtttctgat attcagaatg atacaggcag ccggttccgc 2916961 agcactgcct cttattgctg ccacaacgat cggacagctg tttacaggaa atgaacgcgg 2917021 gagtgcaatg ggaacgtatc aaatgctcct gtctgtcgca ccggctattg ctccagttct 2917081 aggaggattc ataggcggag cagccggata cgaagggatt ttttggatac ttgcggccat 2917141 ctctatcgtt ttgctggtga caaacagcat cacctttcct aaagattctc caactgaatc 2917201 tatgcagcaa gccaaaggca atgtgttcgc tcattataaa tcaatattta caaatcgaac 2917261 agggaacgtc attttgactt taagttttgt tctctttttc atttattttg cagtaattgt 2917321 ctacctccca atattgctga cagagcatta ccatatagat gtgggtatag caggactgtt 2917381 atatttgccg ctggcgctga gcacgattgc aggtacgttt ctgtttaaaa gaatacaggc 2917441 aaaaatcggg ctgcacacct tgtttatcgg aagcaatgtg attgccgcct gcagcatcat 2917501 tttatttgct gttacacatt ccgtttctct cgttctcatg gctctgacgc tggcactgtt 2917561 tggcatctcg atgggggtta ttcctccctt gtactctaca atgattacta atgaatttga 2917621 gcacaacaga gggagtgcaa tcggaatgtt taactttatc cgatatacag gcatggcagc 2917681 aggtccgatg gtatctgcct acttgctcac aatgatgccg tctgccatgt cctttagcct 2917741 cctaggcctt ggatttgccg cattgagctt ttgccttctt ccgccaatgt tttcgccgca 2917801 gaagcgcacg aaacaaaaaa agcaccacat gtaaaaaagc tgcctttgcg ggcagctttt 2917861 tttatttttt tctaagcggc tctaaaatgc ctttttgaat cagcaaatgg aagaccgaca 2917921 ggataacgga tgcccatatc gctgtgccga agccgtcgat ttgaaagctg tcacccataa 2917981 tggacgcggt catcataagc gtgatggcgt taatcacaaa caagaagagt ccaagcgtca 2918041 ccatggtgac cggcagtgta aatataatta aaagcggttt aatcagcacg tttaagatcg 2918101 ataaaatgag gctggcgata atcgctgccc caatgctgct gatatggatg gagtcaatat 2918161 atccatcaat gacgattaat aacaatgcat tgactaaaat gctgactgcc cattttacca 2918221 tgtcatttca tatccctttc tgacgggacg ataaaaatcc aaatgatata aatgagcaaa 2918281 accggcaaga cacttgtcat aatggctaag atgacagtta tgactctgag gagtgatgcg 2918341 tcccaattga aatattccgc gagacctccg ataacaccgg cgattttctt atttttttct 2918401 gagcgataaa gcttattcat tcgatcacct ctgtgagtac tttagtttga tggcgcctgt 2918461 tagtgattct gagaagacgg tgatgttttg atcatgtgcc tgatttgaag tgaacatcat 2918521 ttctttttga atcgtatcat ttttttcctt cagcatctct acatccatta attcatggga 2918581 cagcgtacca agattgcttt tcagctctgc cttcactgcg agatcgtccg gaattgcaag 2918641 ctctacattt ccagtcgttg tttttgcata aatggagcgg cagtctgatt ctgttacgtt 2918701 aatcgcaata tttccgttaa agctttgaac gtcaatggat tcgcttttcc ctcggagatc 2918761 gatcaatccg ttaatggttt ccgcttctat cgtaccgcag ctgtggcttg cgagcttaat 2918821 ttgcccgttg gccgtttcag ctatggcttt ttcggctgtt aaatacgaga acgacagcac 2918881 gccgtttgtc gttttcgctg agaactcttt tacatgtaaa tgttcccctc tgactggacc 2918941 gttaaacagc ttcacccgaa tcttatcata ctccttctga ggaatataca aagtgacatt 2919001 cgttttcatc gtctttttct cagtacggat aaaaaactta ttacctttga tttcacattc 2919061 aatatgctga agaaatgcgt gtctcgccgc atcctggctg tcagcgcgat ataccttcgc 2919121 ctggcattcc gctctgatat cgtcatcttc ccaagggacg atatttacgc tgccattggc 2919181 aatttgcagc tcaacactgg aaaagtcagt atctttaaat tgaaaaatgt gctgaacatc 2919241 atacgcatgg ccaaagttta aatcaaggtc aacttccttg acctttttca cagcagaatc 2919301 aatccagtca aacagcttgg ctcctaaaga cggtttgccg ctttcttttt ttgccgttgt 2919361 aaatggctct tcctcgtcat gaacgtgaac tgagagcgct gtgattttct cttctttttc 2919421 cttgtagtcg ctgtcaagct tttcaatcag tgtcaaagct tcttgtgctg taagctttcc 2919481 ttcctcaaca agcttaagga ttcgttcctt ttcttgcttc attacgatct cctccccatt 2919541 gtctacttat gctgcacgca ggaccttaat gccctgaatc acattccaaa tgataatgcc 2919601 aatgacaact aagaaataaa taaccgctcc cccgatgatt acaaatacag gaagcaagct 2919661 gtctccatca atcgcaacgg ctccgccaag taaagcaata aaaaggaaca gccagccgac 2919721 aaacggaaca atgtgagaaa taagagagcg tatcgcatgg cgttttgttt ctttctcatt 2919781 tacaacaaaa tatgcgacaa tcggcacaat gattggcgca atgaacacac tgaaataaca 2919841 aagtgatgca ataatagctt gattacggtt caattcattc cacactccta ttgtgaattg 2919901 tccatgacaa aagatcaggg acgttttact tatttatacg tttaaaatct cttcaggttt 2919961 caaattcatt ctttagacat gctccgattt acggaaattg gattttaaaa agttttagaa 2920021 gtagaatctt ccggctatac cgattacaat atgtaaaaag cttacggcaa ccaaggaggc 2920081 tggacaagca atggagaaag atcccagtga ctatacagta acacaagaat cagtgttaaa 2920141 gctgattcag gaacaaaaaa gaatgaatcg tgaaatgatc accgagcttg agcagattca 2920201 cggacccttc ccgatctctc acgatatcca atatataaaa gtgctgctcg acagcagcaa 2920261 cacacatatt gttcaagatt taatgagtgt aagtaagcag ctgtataaga agactttgta 2920321 attgcggaaa acatatcatt cattataact gaaacaaagc taaaggttag atgacaatat 2920381 cttgcctttt ttgttttgaa aaaacaagtg attccctggc tgtcacaaaa tgattgtaac 2920441 aaaaaaagcc tgccggcaca tccagttaat ggactctgtc ggcaagctgt aactatcaga 2920501 aagagatagc cgttcaaaat taacgtaaca attgaagcac gttttgcggc tgttggtttg 2920561 cttgagcaag catcgcttga gaagcttgag aaggaatgtt gttctttgtg aactcgctca 2920621 tttctttcgc catgtcaacg tcacggatac gggactcagc agctgtcagg ttttcagaag 2920681 aagcaccaag gttgttgatt gtgtgctcta gacggttttg taccgcacca agtttagcac 2920741 gttggtttga gacattgttg attgcagtat caatactttc aagttgtgta tcaaaaggag 2920801 tattagcaaa atctgttaca ttaagtgcgt ttactcctaa agcagttgat gacatgctgt 2920861 caatgttaac tgtaagctgc tggccagcat ttgctccaat ttggaaagtg aaaccatcag 2920921 tttcagtacc atctaataac tttttgccgt tgaattcagt acgatttgaa atgccatcaa 2920981 cttcctcaat aagcgcatcc atttcatctt taattgcacc aagatcttct gcttgttgtg 2921041 tacctgtgtt tcctgcttga acagtaagtt cacttctaaa cctattatgc cgtaaagaaa 2921101 aagcttgcct gctaagccca aggatggact tgccgacaag ctgtcccctc ttaacagagg 2921161 gttttaagat gtagctgttt cttttgcttt caagagcgat ttcatgcgtg ttttgtcacg 2921221 ttcgataaca ggctttaaat aacggcctgt atacgattct tcaacttcag tgatttcctc 2921281 aggcgttcca gacgcgacaa tggttccgcc tccggctccg ccttccgggc ccaaatccac 2921341 aatgtaatcg gccgtcttaa tgatatcaag attgtgctca ataaccagta cagtgtctcc 2921401 gttgtctacc aaccgttgca gcacgacaag aagcctggcg atatcgtcga catgcaaacc 2921461 tgtcgtcggc tcatctaaaa tgtagagcgt acgtccggtt gagcgtttgt gcagctctga 2921521 cgcgagcttc acgcgctgcg cttctccgcc tgacaaggtc gtcgccggct ggccgagcgt 2921581 aatataacct aaaccaacat cataaagggt ttggagcttg cgtttgattt tcgggatatt 2921641 ttcaaagaaa gaaagagcat cttcaaccgt catatcaagc acatcagaga tgctttttcc 2921701 tttgtacgtc acttcaagcg tttcacggtt atagcgtttg ccgtgacaca cctcgcatgg 2921761 aacgtatacg tcaggaagga agtgcatttc aattttaata atcccgtctc cgcggcaggc 2921821 ttcacatcgt ccgcccttca cgttgaagct gaaacggcct tttttatagc cgcggacctt 2921881 cgcttcattt gtctgcgcga atacatcacg aatgtcatca aatacaccgg tgtatgtcgc 2921941 agggttggat ctcggcgttc ttccgattgg cgcctggtca atgtcaatga ctttatctaa 2922001 atgatccaaa cctttaatct ctttatggct gccgggcttc gctttcgctt tatgaagctt 2922061 ttgcgccagc gccttatgca aaatttcatt aacgagtgta ctctttcctg aaccggaaac 2922121 acctgtaact gctgtaaacg tcccaagcgg gaacttggca ttcacttttt tcaggttgtt 2922181 ttctgatgca cctttaattt caatgtaacg tccgtccggc tttcttcttt caggaggcaa 2922241 tgggataaac tttttccctg ataaatagct gcccgttaat gaatttggat cttccatcac 2922301 ttcttccggc gtacccgcag atatcacctg tccgccgtga atgccggctc ccggtccaat 2922361 atctattaaa taatctgctg ccatcatcgt gtcctcatca tgttcgacaa caatcagcgt 2922421 gttcccgagg tctctcatat ttttcagagc gctgatcaag cggtcgttat cacgctgatg 2922481 cagaccgata gacggctcat ctaaaatata aagcacaccg gataaacgcg agccaatttg 2922541 agtcgccagc ctgatgcgct gcgcctctcc tccggacaat gtacccgctg ccctgctcaa 2922601 tgtcaggtaa tcgaggccga ctttgtccag aaagcttaag cgctccacaa tttcgcgcaa 2922661 aatcaaattg gcgatctgca tatccttctc agaaagggta agatctttaa agaaggcaag 2922721 tgcgtcggcg acagacagct cggtaatttt cccaatgtgg cggccgtcaa tcagtacggc 2922781 aagcgcctct ttctttaacc gatagccttt gcacgtcgga caagacttct gagacatata 2922841 ctgctccatt tgctcacgta tgaaatcgga gcctgtctcc ttatagcgtc tttcaatgtt 2922901 gcgcaatacg ccttcaaatt gaatttcacc ttcgcggatt tgtccaaaat cattttcata 2922961 tcggaaataa atcaggtcat ccccgctgcc gtacagcact ttatccagtt gatgcttcgg 2923021 caaatctttg accggcacat ccatatcaat cccgtagtgg gtgcagactg cctcaagcag 2923081 ctgaggataa tattgtgagc tgatcggtgt ccaaggggcg accgcattct ccttcaatga 2923141 caaatcttga ttggggatga caagatcggc atccacttca agcttcattc cgagaccgtc 2923201 acacgtcgga cacgccccga acggactgtt aaacgaaaac agacgcggct caagctcacc 2923261 aattgaaaat ccgcagtgcg gacaggcatg atgctcgctg aacatcagct cttcctcacc 2923321 gatgacatcg atcataaccc gtccttcacc taaacgaagc gccgtttcca atgaatctga 2923381 cagccgggct gccacgcctt ctttcacgac aatccggtca atgactacct caatggaatg 2923441 cttcttgttc ttttctaatt cgatatcgtc ggaaagctca gccatctcgc cgtcaattct 2923501 gactctgaca tagccttgtt tcctaatctg ttcaagcact ttgacatgag cgccttttcg 2923561 gcccgagaca atcggcgcca gcacctgaag cttcgtccgt tccgggtatt ccagaattct 2923621 gtccaccatt tgctcgatgg tctgggatgt aatctcaatt ccgtgttccg gacaatgagg 2923681 cttccctact ctcgcatata aaagacgcag ataatcataa atctcagtta ccgtaccgac 2923741 agtagacctc ggattgcggc tcgttgtttt ctgatcaatg ctgatggcgg gagagagccc 2923801 ctcaattgca tccacatccg gcttatccat ttgccctaaa aactggcggg cataggcaga 2923861 cagcgactcg acataccgtc tctgtccttc agcatatatc gtgtcaaagg caagggagga 2923921 tttacctgat ccggacaaac ccgtgacaac gacaagctga tctctcggaa tcgttacatc 2923981 tatatttttc aggttatgcg ccctggctcc cttcacctct atccgatcca tagccatttg 2924041 ttcatcatcc ttccgctttt agctctaaaa gtaaatcgcg aagctccgcg gctctctcaa 2924101 agtcaagcgc cttggcggct tccttcattt catgctccat ctgttcaacg actttctggc 2924161 gttctttctt cgtcattttc gacagcttcg gcgcggcttt tgttttgtat tccgctttat 2924221 cctcagctgc tactgtggca cgaatgacat cgcgaatttc tttatttatc gttttcggcg 2924281 taatgccgtg ctcttcgtta aaccgctcct gctgctcgcg gcggcgtttt gtttcattaa 2924341 tcgcaatttc catagacttc gttattttat cggcgtacat aatgacgcgg ccttccgcat 2924401 ttctcgctgc ccgtccgatg gtctggatca gcgaccgctc cgaacgaagg aaaccttcct 2924461 tatccgcatc caaaatcgca acaagggata cttcgggaat gtccaaacct tccctcagca 2924521 ggttgatgcc gacaagcaca tcgtacttgc caaggcgcag gtcgcggata atttcaatcc 2924581 gttcaagcgt cttgatctca gaatgcagat agtttacttt aatgccgatt tcctttaaat 2924641 aatcggtcag atcctctgac atcttcttcg tcaaagttgt cacaagcacc cgttcattcc 2924701 gctcgattct tgcttgaatt tcgccgatca agtcgtcaat ctgaccttcg attggacgga 2924761 cgtcaataag cgggtcaaga agccccgtcg gacgaatgat ctgttcgacc atttcatctg 2924821 tatgttcaat ctcgtacggc cctggtgttg ctgatacata cacgatattg tgcatatgct 2924881 tttcaaattc ctcaaaacga agcggacggt tatcaagcgc tgatggaagc cggaagccgt 2924941 gatccacgag cacctgtttc cgcgcctggt ctccgttaaa catgccgcgc acctgaggaa 2925001 ttgtcacatg cgactcatcc accacgatca taaaatcgtc tgggaaataa tcaagaagcg 2925061 tatacggcgt tgaacctgga ggccgcagag tcaaatgtct tgaatagttc tcgatgccgg 2925121 agcagaaacc catttcacgc atcatttcaa gatcatatct tgtccgctgc tctaaacgct 2925181 gcgcttcaag gagctttccg ttttcatgca tgaccttcag ctgctcctca agctccttct 2925241 cgatattttg aatcgccttc tccattttct cggcccgcgt tacgaagtgg gatgccggga 2925301 aaatcgcaac atgatctcgg tcgccgagaa tttctcctgt cagcgcatct acttcccgaa 2925361 tccgttcgat ttcgtcaccg aaaaattcaa ctctgacaca atgctcatca cgggatgccg 2925421 gaaagatttc cactacatcc ccgcgcacac gaaatgtacc gcgctgaaag tcgatatcgt 2925481 tgcgggcata ttggatgtct acaagttttc tgagcagctc gttgcgctca atttccattt 2925541 cagtccgcag tgacacgacc atttcccggt attcctcagg cgaaccgagg ccgtatatac 2925601 aagacacact cgcaataata atgacatctc tgcgctcaaa caaagctgat gtggcggagt 2925661 gtctcagttt atcaatttca tcattaatac tagcgtcttt ctctataaat gtatccgttt 2925721 gaggcacata cgcctccggc tgataataat catagtagct gacaaaatac tcgacagcat 2925781 tgttcggaaa aaattccttg aactcactgt aaagctgtcc agcaagggtt ttgttatggg 2925841 caatcacgag agtcggctta ttgacttctt taatcaaatt ggacaccgta aatgttttcc 2925901 cagttcctgt tgcacccagc agagtctgat gcttcttgcc ctcctgaatt cctttcacaa 2925961 gcttttcaat ggctttcggc tgatctccct ggggctgata tttcgagact aactcaaagc 2926021 gatctttcac aaaaataagc ctccgtttct ttaacgaaat cttcctatag atatagtaac 2926081 acaatggaaa gcaaaatcac taaaaatacg aactaaagtt cggtggtttt ttatttccag 2926141 ctgtttttgt gtataaaaaa cctgctttta aaacgtaaaa gcaggtattc agtctttata 2926201 ttcattatgt ccgatttatt cttctttttt ctctgcagct tttttggcca tatacagtcc 2926261 gccagccaca agagacacaa catccaatcc tacaataaaa tacgtttctg tatagccttt 2926321 taaataagag gcaaacagca atgcagctgt taaagcgatc gccacataat gattaaaggt 2926381 gactctagta aatagaacaa caagcataaa agggaaaaac aatgcaaaaa cggcttttgt 2926441 aatcaacaaa aaccctcctc agggattctt catctgatct gattatagta aaaaatgaag 2926501 aatcggacaa tcgtgcattc gctccctcta cttacaccat accccttttc agccaaaatc 2926561 aatcaccata tttgcatttt ggtgccggtc aaaacttatt ccatggtgcc gctgttctaa 2926621 tcagcggcac tttttttatt acatcatcaa gtccgccgcc agattccgag aataaaagaa 2926681 aataggcata cagtaccagt acggccgcat ttttcaggat aatataacca acttaactat 2926741 tcattttatt taggactttc tgcgtttgac agcattttcc tgaaaaccta caattaaatg 2926801 atagtgttta ctatcatttt ttaaacacag gctccgcaat aaaaagacta gagagaaaaa 2926861 caaaatgaat gaagaaaaga ggggtttcaa atatgtattc tgttttattt cgccaggcag 2926921 aagagtccag ccagctggct ggagcaaaag gaatgaattt gattaaattg accaaacacg 2926981 gtcttcctgt tccggacggg tttattattc aaacgaatgc gctcgcacgt tttatggagg 2927041 acaaccagct tcaagagact agtgaaaacg tcgaaggcgg gatcatttcc ggaacatttt 2927101 cggatgagct gaaagatgag ctgactagtt ccttttataa gcttagagaa tcatatcgat 2927161 ccgtagccgt gcgttcttcg tctgcttcgg aagatttaga aggcgcctca ttcgcgggtc 2927221 aatatgaaac ctacttaaat atcaaaacag aggaagagtt tctggctaaa gtgaaagaat 2927281 gctgggcctc atttttttct gggcgggtca gcagctataa gaaaaaaatg aacaatcaaa 2927341 tcgcagagcc gttaatggga atagtcgttc aggggctgat cgattcagaa atgtcaggtg 2927401 ttatcttcag ccgcaaccct gttacccatg atgatagaga gcttttaatc agcgccagct 2927461 acgggttggg tgaagctgtt gtttcaggaa atgttacccc agacacgttc attgttaata 2927521 aatcttcgtt tgagattcag aaagaaatag gtgcaaagga aatctacatg gagtctgcgg 2927581 cagaaggaat tgctgaaaaa gaaacgagtg aagacatgcg cagccgtttt tgccttacag 2927641 atgaacaagt gattgaattg gctgaaatca caaaaaaaac cgaagacctg tacggatatc 2927701 ctgttgatat agaatttgga attgctgatc atcaaatata ccttctgcaa gctcgcccga 2927761 ttacaaccat tgatcaggac aaaaaagcgg cagaagaaaa acgcagcttc atgattaccg 2927821 acactgatat gaatgatttc tggcttaaca tggagtctaa tattgaaggt ccggtgagtc 2927881 cgttattttc atccttcatc gtgccggcat tggaatatgg cttgaagaag agcatgcaaa 2927941 agtttccgat tggtgtagtt gttgatgaag taaaacttta tcgcggacat atttattcca 2928001 aaaaccaagg cggacagcag cctccttctg aagactgcgg caaagagctt ttcccgattt 2928061 tatcggagca tatgtatgac atcatcaatc acacatacct ccctttttac cggacactgg 2928121 accagctcgc acaaactgag cataccgcag aaagcgcact ggaagctttt caaaaactaa 2928181 aggcctttta tctcacggct tatgaagagc actttaatat cgttttcccg caaatccttt 2928241 taacaaacaa actgcaagcg atgtatcagg acattcaagg agagtccgaa aacgctcatt 2928301 tttacgagat gctgacagga aaaatgaaca aatcactgga aacggaccgt tgcttatggc 2928361 tattttctgt ggaagttcag gagaacccga accttctggc catttttgaa aacaacaagc 2928421 ctgaacagct ccaggagaaa ttggaacaaa cagatgaggg aagacacttc ctgaagaacg 2928481 tccatgaatt cttgcaagaa tacggatgga gatctgttaa aagtcatgat ctgattgaac 2928541 aaatctgggt ggaaaatccg tatttcgctc tggccaatat tcaaaattat gtccgtaatg 2928601 gctatcattt tgacaatgaa tttcagaaaa caaaagaaaa acgagagaaa ttatacaatg 2928661 aattcttgga aagcatagaa gatcccggtt tacgcaccga atttgaccgc tattatcaat 2928721 ggacactgaa ctctgcaaat ataaaagatg atcaccactt ttatattgac gccatgctgg 2928781 atgccaaggc gagaatcttt ctgctgaaga taggtgaatt gctggcggaa aacggtgtca 2928841 ttcaagatcg ggaggacctt tggttcttat atgacgacga agtggaacaa gcgcttcttc 2928901 accctgtatc cctgcaagaa aaggctgaaa aacgcagaca gatttttcat gagtatgagc 2928961 tggcccaagc cccggcctac ctcggcaccc cgacaaaaga acagctcaaa gcagctgaag 2929021 aaattgtcgg cgctgtgata gaggatgaaa aaaacacaga gaatcatatt tttggcattg 2929081 cggcatcaag cggcattgcg acaggtccgg tgaaaatcat tcgggacgcc aatgaatttt 2929141 ctcaattcgc gcctggagac gtactcgttt gcaagatgac cacaccgcta tggaccagcc 2929201 tgtttcaaga cgccaaagcg attattacag acacaggcgg cattttgtct cacgctgcga 2929261 ttattgcccg tgaatacggc attccagccg ttctcggcac acgcacggca accgaaagac 2929321 tgcgagacgg tgacatcatc actgttgacg gaagcagcgg caaaatcaca gttgtcagcc 2929381 ggtcctgatg cgtccccctc tttcttatac aagcggggcg ggtgtatact tgtcctgcca 2929441 gtatattcgt gaggtgaaac gtattgagac cgacaaacaa gagaatcctt gatgctgcca 2929501 tgcagctgct cgtcaaaaaa ggatatcgcg caacgactac aaaagaaatt gcagaaaaag 2929561 caaatgtaag tgaagcgacg attttcagga actttaaaaa caaacaagga ctagttgagg 2929621 ctttgctttc tcagcattct tcaaacagag gcagcatttt ggaacaaaca gaaggggatt 2929681 tgtacaaaga cctgcttcat atcggaacct gtctcttgga ggagctcgaa catagaaaag 2929741 atatcattaa aatcagcttt cgtgaaccgg ccatgtttca ggatgtcatt aaccacgtca 2929801 ctgaatatcc ccaatctatg aaacagctat tggttgatta tctcaaaacg atgggtgaga 2929861 aaggggttat tcagacagga aatgaagcgg aacatgccga cgtgttcatg tcgattatct 2929921 tcggttattt cattcaccgt ctccacttag gagaccgggt catatcaatg ccccaggaaa 2929981 aaatgctgga gcatagcaca gctctatttg tcaaaggaat ttctgctgat taactccttg 2930041 gcataataaa aaggaggatc ccaatgagct caagaaaaga atgggcgctg atcgtctcgc 2930101 tattattggg ggccattctg gttcccatta actcaacgat gatcgcggtc gcgctctcat 2930161 ctatttccca tacgtataac gagtccatcg caagcatcac ttgggtggtt accgtttatt 2930221 taatcgtgat ggcagtcaca cagccgattg caggaaagct cggtgacatg tacggcaata 2930281 aaacaatgta cttatgggga gtcggccttt ttctaatcgc atctctaggc tgcgcccttt 2930341 caccgagtct gctcctgtta attgtctttc gggcattgca ggctgtcggc ggggcattgc 2930401 ttacgccaaa cagcattgcc attatccggc atgttgtttc tgaaaaacgc ctaccgaaag 2930461 tgtttggatt tttcggactg ggcgcgggac ttggtgcagc actcgggcct tttatcggct 2930521 ctatactgat tgacagcttc agctggcatt cgattttttg ggtcaacatc ccgttcctcg 2930581 ccattgcttt atttacggca ttaacgatgt ttcctcaata taaagaaaat aaatctgacg 2930641 cgccgctgga tatcatcggc tctctcttgc ttgcaggcag catcgtttcc attatcctgc 2930701 tgacgaaaaa tgaggctcca tggggatata ctgtatacag tgtattgata cttctttttg 2930761 ttccgctttt tttcagaaga gaaaaacgta cccagcaccc catcattgac tttgcactgt 2930821 ttaaaagctc aacctttaca aatgcgaatc tatcagtctt gttaagcaat ttgatgatgt 2930881 atgccgtctt attgattatg ccgttattta tgacgaacca atttgggctt aatacatcta 2930941 acagcgggat ggcgctttct gtattttcga tcttcatgtc agccagcaac tgggtgggcg 2931001 cgcagctcca tcacaaatgg ggagccaaaa aaatcatttt tctttcattt gccatgatgg 2931061 ctggtgcgaa tctattattt ttgctgttaa gcagctcgca ttctgtcttg ttcctcatgc 2931121 tctctcttat ccttggcggg ctcgcttccg gagtcggtct gaccagcatg caggtttcat 2931181 cccttgccac agtagacccc ggtatgtcag gagtggcatc tgggattttc tcgaccttcc 2931241 gttatttcgg aagcatcatt tcatcagcct taattggcct gatttcggga tatcacaccc 2931301 tatttatgat tctctttgct gtatccatca tcggcgtttt tgtttcattg ggcatcaaat 2931361 ctgatgaaac ggcacggata gaaaaaaact cagcgtaaca caaaacagcc cggcatcgca 2931421 tcatcctgcg gtgccgggct gccttttatg atcccgaagc gactgcttcg tcttcacggt 2931481 catcctttac gaagaggatg cccaattcat gatgttctcc ttcataagaa gctcgctggt 2931541 caaaacgaat ttctccattc aaaccgataa tttcaagctt tacatatgca cggttatgct 2931601 gaagcgcttc atagaaatca gaaacgttct taaccggtat gccattgact ttcgttatga 2931661 tttccccgat tttcaattcc agatcctcag ccggcgtatt ggggataatc ccaagcacca 2931721 ttaagccctg atcccttttc gagaaataaa acggagccgc gttatcattc actctttgct 2931781 ttatggacag aaaaatacgc cctaacaaag cggtacagac cgctgcaccc gcaagcggcg 2931841 tccacagtaa gctcgctgca ccgagaactg cgacggcaag accgagaata caaacgcgtt 2931901 tcgctgtgat ccttatactc gtttcaggca gcgatccctg taccctttgt ccaaatccga 2931961 caaagtaagg aatccataga aaatggaatg agccgccggg aaccgtaaac acgggccacc 2932021 agctaaggtg cgattctaaa ccattaccgg gcacgagaag gaacagcggc aaaagccaaa 2932081 cccggtttgc cagctgctgt ccgatcggca aaccgcggct gcttacgaca agtgccggtg 2932141 atgttctcac atgcgcagaa cgataagcaa ccgctccttc agtgataatc agcaaaccta 2932201 gaaacacagc cacagccggc caaacaactg caaatccttg cggaaatctc tccagaaagg 2932261 gctccgcctg atatatttgc agtccaaaac ctatcagcat actcacactg acgatatatg 2932321 cagcagacat ccagtttgcg cgaagagtga acgctgccgc tgcagtgata acggcaataa 2932381 tcgcaagtaa accgagagga atcgatattc cgagtccacc taaaataact gacaaaagaa 2932441 gacctggaat cagtcccttt gtatatgtaa atttcagatc atcataaata tctgctattc 2932501 ttgtatgaaa ggtttttcgt tcccgtttga ttcttacata gccgaaagcc aaggttatga 2932561 tgataaaaaa ccagaaaagc gggtgtaaga agaacaagcc cgcgcttttt aacagttcaa 2932621 ttccccattg aacagacact atctctcacc gcctcaagcc aaacatgtta ctcatattct 2932681 atcaaatatt aaatggcttg gatatcctca ggagagttta tctctcttgc gtcatccaca 2932741 gcgtgacatt cgatagtgaa aaatccttta aatagtggtt tacatccaca tccaataacc 2932801 cgctgattag atgcatcgac ctttttatat ctgtcagatt aattcctaat cgcttatggt 2932861 ttttcattaa gtagttaaaa taatgtttgg cgcattcctc attaatgtca tttactgatt 2932921 cgacattggt gtaattgacc aaatatctgc tgaacagcat aagaagactt agtgcttttg 2932981 tagctgaaaa tgttacgtct tgtgttctgt cttttaattg ttccactaat tcataatatt 2933041 tttttttcac gcacaatact tgccctcttc aattgtgaac ccccattttc tttatacaga 2933101 taagcacggg ccagtataag cagcagtact ggagtgctaa caagcattct cgctaacgtt 2933161 actctttaaa tacctgtcgt tcagctgcca ttaacctgat tactgttctt tttagaacct 2933221 tcttatattg tatgaagtaa acaaagacta ggcaacttgc aaaagtttca ttttaaatgc 2933281 atattaactc gttagaaagt ctctctcata tattgatatc gggtaataac agtcctttat 2933341 aaatgtttat ttgtgaaaat ttttttaatt tcttgtcaaa aactcatttt ttatgtgact 2933401 tatgatccat aatctcttta agcacaaaga aacaggagat gaaataccat ctcctttaat 2933461 tgacaaataa tgatttcaat gctgtttgaa gctgcaaatc atttttttca tctgattttt 2933521 tcttttctat ctgctgattt aatgtctctg cagtgcgagt gtcgatcaca ccggttttat 2933581 tcagcttgtt ttgatcctga aaagccataa ccgctttttt catgtctttg ctgaaatagc 2933641 catcctcacg tcccggatca aagctgagac cttttaacaa tacctgcgca tgcttgacgt 2933701 cttcattgtt catgtccact ttaagcggct ctttcagctg taagggcccg gcggaaaaat 2933761 aatcgggctg cttaatcgca atggtcggtt caattccttt cttatgaatc cagtttccat 2933821 ttggcgtcag ccacttgtaa agcgttaatt tgatgttgct gccgtccccc attggcacag 2933881 cctgttgaac cgttcccttt ccaaaagacg tatcgcctac aacatcataa tggccagctt 2933941 cctttaatgc gccggcaaga atttctgatg cagaggcact tcctttatcc gtaatcacat 2934001 tgacagggta cgctttttta tgggtcaatg ttgaaaaata acgtttttta tctccattgc 2934061 gttcagcaat ctgaatatac ggctgatcct ttgtaacgaa atgcttaaga atttcttcca 2934121 cactttgaag atatccaccc gggttgccgc gtacatcaat gacaagtcct tctatttctt 2934181 ttttctcaag ctccctcagc gcttttgcaa aatcctctgc ggtgtgctca gaaaaagtag 2934241 agatggcaat atatccgaca gaatgcccct gtactttttt ctctgatgca aaaaccgttt 2934301 cgagcggaat ctcagctctc ttgatccgga atgacaactg cttcttcgtt ccaggccgct 2934361 gaatcttcat tgaaacgctg gacccttttt ttcctcttat ttttaacaca gcgtggttta 2934421 aatccttgcc ggccatcgat tctccattga tgctgataat ttcatcatta ggcttcaacc 2934481 cggctttttc cgctggcgat ttcttgaatg gagaaacaat aataattttg ccgtcttcca 2934541 ttccaacctc agccccgatg ccttcaaatg aggaatcaag agaatcagaa aattgcttag 2934601 ctgtctgctt gtccatgtaa acagaataag gatcatttag cgtagacagc attccctgga 2934661 tggctccctc gagcagcttt tctctatcta ctttttctac gtactcattc gaaattaact 2934721 catacgcttt ttcgattttg tccatagctt tatcccgttc agagtcagct tgtgccgtcg 2934781 cgggaactgc tgcagtctgg ggcttatcca tctcaagcag gttgattccc gcatatacac 2934841 cggcgcctcc gaacagcatg ctccctgctg ctatcacagc cattattttt tgattcatcc 2934901 tttactcctc ctgtatgcca gactgtcttt accaaaacct agagatagta tatgtaaagg 2934961 atggagattt catgtaatca tagaagaaaa agaaggcaaa tgaaaagccg tcccgaaaac 2935021 ggaacggctt tttcacttta tactcgcaga aacttgcgga tggaagtcag acttccccat 2935081 actccaatta ctgcgccgat tgcaatcagc actagcgaaa cttggaatac aaatggatta 2935141 taaggaagaa gagagacaaa tgatccttga acctttggaa cgacccatcc gatgacgtat 2935201 tggtaagtgc tcagcaccag tgcaatcgga atcacagaac cgaatacgcc tagcagcaat 2935261 ccttcaagga aaaacggcca gcggataaac cagtttgtcg cgccgacaag cttcatgatt 2935321 tcaatttctt ttcttcttgc gaaaattgta attttaatgg tgttggaaat taagaacatc 2935381 gccgtaaata ccaggccgat aattaacgcg attccgatgt tgcgggaaac gccgaccact 2935441 ttaaacaaac ggctgacctc ttcttttcca taagtgactt tataaacatg atccattttt 2935501 tcgatctttt tcgccacgtt cggcgtatca tgcggatctg tcgttttgac gacaaacgca 2935561 tcattaagcg ggttttcctg atccttcatt gtcagggatt ttccgctgtc accaaaactg 2935621 tcaaccagct ggtcaagctc tttttcttta gatgaaaaag tgacactctg aatgcccttc 2935681 agttccttaa tatcgttctg aagcttgtcc tgtgccttct gatctgcagt cagatcaatc 2935741 agcactttga tttcgacttg tttttctgca ttcgtggcca tgttattcaa attcagcata 2935801 atcactaaaa acacgccgac taaaatcagc gtaacggtta cagcactaat ggatgcaaat 2935861 gtcatccatg tgtttctccc gagagattta aaactctcac gcaagtggcg cccgagaatt 2935921 ttaatcatat gaaccatact cccctcttga ctcatcacgc acaatgatac catcttcgat 2935981 tgcaatgaca cgtttcttca tggtgtttac gatttcttta ttatgtgtcg ccatcacgac 2936041 tgttgtcccg cggttgttaa tttcctccag cgtcttcatg acttcccagg acgtatccgg 2936101 atcaaggttt cctgtcggtt catcagcaat gacaacatca gggttgttca caattgatct 2936161 ggcaatagat acacgctgct gctccccgcc tgaaagctgg tcaggaaatt gtcgcgcttt 2936221 atgcttcagc tgcacgagat caagcacttc aagcacccgt ttcttaatga cagacggctg 2936281 ttctccaatc acttcaaggg caaatgccac attttcaaaa acagtaagtt tcggaagaag 2936341 cttgaaatcc tgaaagacaa cacctatttt gcggcgcacg aaaggaatct ctttttcttt 2936401 aattgtcgcg agatctttat gattgattaa aatttgtcct tttgtcggtt tttcttctct 2936461 gtaaatcatt ttaataaaag tagatttacc tgctccgctc ggaccaacaa catacacaaa 2936521 ctcgccggga tgaatggtaa cagaaatccc attgagtgct tttacgccgt tcggataggc 2936581 tttatatact tccttcatct ctatcatgaa atcacctaat cttttatatc attttatcta 2936641 tcacacggtc atactcttcg aatgcattcg acaatttatg acccattcat ttgtaaaaag 2936701 atgaaaaatc tgaaagttcc ctttttcaat acacttcatt atacgtcaaa tttagacata 2936761 atactattac agtttctttt cattcatatt gtcaaggcat aaaaacatcc ttgccagcac 2936821 tcggcaagga tgtttttatc ttactttttt tctgacagcc atttggcaat aacagcggct 2936881 tcgttatcat ctacaagccc ctttggcata ttgccgcggc cgtttttaat aatgctttca 2936941 attttgtgtt catcgtattt gcctccgacc tcttggagat taggccctga cacaccttct 2937001 aaatccttgc cgtggcagcc tacgcagctt tgctgatata attcttcccc ttcagatgca 2937061 gtggcttccg tcttgctgcc agtgtctgtc ttctcttctt ttgcatcgtt tgatccgcag 2937121 gcagccaaca gaacagaaag cgcaaatcca atcattagta tcgataactt tgatttcatg 2937181 ttgagaagca caactccttt acgatctctt ccatattata acctcgttta agcgcgtttg 2937241 aaaccctcgc ccagcacctc gctcgcgtct gctacaatta caaaagctga ctcatcaatc 2937301 tgtttgacga tttgtttcaa tttggtgaat tcagtttgcc caaccacgca cattaaaatc 2937361 ggacggtcat cgtcagtata tccgccgact gcagaaattt ttgtcacgcc tctgtcaatc 2937421 ttctgtaaga cagcctcctt gacagcctgc tcctgctttg taatgatgag cgccattttt 2937481 gaacgattaa agccgacttg cacaacatca atggttttgc tggacacata gacgccaagc 2937541 atggcatata agccttgctc aatattaaat acaatcatag ccgtaacaac gatcattccg 2937601 tcaatgatgg cgagacactt ccccaatgac agaccggagt acttatgaat gatctgtgca 2937661 gccaaggctg tacctcccgt cgaacctttc cctaagtaca caataccaat tccgatacct 2937721 atcccgacac cgccaaaaat cgccgccagg agttcatgat gagtggcggg ctgaatatcc 2937781 cttgtcagaa acactactag cggcaaaaac acagaacctg caagcgtctt tagtccaaat 2937841 ttcccgccga gcaaaatgac gccagcaata aataaaggga tattaataat ccactgtaca 2937901 tacgctgctt caaaaccata tgattgtaaa atcgtactga tcccgctgac cccgccggcg 2937961 gcaatcttat tcggaagcaa aaatacatta aaggacacgg ccgtaatcgc tgctcctatc 2938021 aatatgtata cataatcccg caaaatccac aatgttttat tccgtacgtc catcatatat 2938081 cctccgtttc ttccaatgct ctccgatagc attttaatcc ttccctgatt agatgtaaat 2938141 aacacccaaa tacagtggta atatgctaaa gcagcagtga aatcaaggat ataagaaata 2938201 aaaaaacaca cccgtatgca tcaggtgtgt ttttcagctt atgaaagctt agaacgcagg 2938261 taggcatcaa taaacgtatc aatgtcacca tccattacag cttgaacgtt ccccatttct 2938321 gtattggtcc gatggtcttt taccatggaa tacggatgga atacataaga acggatttgg 2938381 ctgccccagc cgatttcttt ttgttcaccg cgaatttcat ccagctctgc ctgctgctct 2938441 tcaattctgc gctgatacag cttggccttc agcattttca tggctctttc acggttttta 2938501 atttgtgagc gctccgtttg gcatgtcaca actacgttcg tcggcaagtg agtaatccga 2938561 acggctgaat ccgtcgtatt gacgtgctgt ccgcccgcgc cgcttgcacg gtacgtgtca 2938621 actttaatat cctccgtacg aatatcaata tcaatttcat cgttaaattc aggcatgact 2938681 tcacatgaaa cgaaagatgt gtggcggcgg cctgatgaat caaatggtga gatccgcaca 2938741 agacgatgaa cacctttttc tgctttgaga tacccgtaag cgttgtgtcc tttgatgagc 2938801 aatgtcactg acttgattcc cgcctcgtca cctggaaggt aatcgagagt ctctacttta 2938861 aagccgcggc gctctcccca tcttgtatac attctaagaa gcatagagcc ccagtcctgt 2938921 gactctgtac cgccagcacc agggtgcagt tctaaaatcg cgttattttt atcatacggc 2938981 tcgctgagaa gaagctgaag ctcaaactca ttgaactctt ttgttaatga ctttagttct 2939041 ttttcaagct caagctggag atcagtgtcc ggctcttctt tcaaaagatc atgagtcatt 2939101 tgtaattctt cgtgggattc attcaatttt ttatacgaat tgacataatc ctttaaaccg 2939161 tttgcttcat ttataaccgt ttgagctttt tgctgatcat tccagaattc cggatcagcc 2939221 atttgttcat ctagctcagc aatgcgggcc tcctttgatt cgaggtcaaa gagaccccct 2939281 aaagtccgct aaacgagaag ccatattttc gagctctgct ctaatttctg ataattccat 2939341 ttcattcacc tcattaaaag atccgcaggc gcctgcaggc gccgcggtca gtaaacttgc 2939401 cggggcgaac tattcagtac ggccgcagca atttttatat tttttcccgc ttccgcagtg 2939461 gcatggggca tttcgtccga tatcaaccac tttgcgaacc ggtgctttct ttgctttttt 2939521 gttatcgtcg ccttcttgcg gctgatgagc tgttgtttga ccttgtacaa cctcttcacg 2939581 ctccagattg ttttcaatct cagctttcat cacaaatttt gcgacttcgt cctcaattga 2939641 ttcaatcata tgctcaaaca tcgcaaaacc ttccatttga tactcacgaa gcgggttcgt 2939701 ctgcgcgtaa gcacgaaggt gaatcccttg gcggagctga tccatcgcat caatatgatc 2939761 catccattta gaatcaacgg cacgaagaac gataactttt tcgaattcgc gcatttgctc 2939821 tttgccgaat tgctcttcct tctcattata ttttgtgatg atgcgatcca taatgagctc 2939881 aagcatttca tccggttctt tgccgaagat atcgctcttc tcaagtgcac cttcatcaag 2939941 ataagttgtg ttgataagat caactagacc gtcaagcttc cactcctcag gaagctcttc 2940001 tcttggcgta taggctgcaa ttgcgcgttc gagagaagac ttgatcatat tttcaacgat 2940061 ttcacgcagg ttttcagagt caatgacttc aaagcgctgc ttataaatga cctcacgctg 2940121 ctggcggaga acatcatcat attgcagaag ctgtttacgc gaatcgaagt tattgccttc 2940181 gacgcgtttt tgagacgatt caaccgcgcg agataccatt ttgctttgga ttggagtaga 2940241 gtcgtccatg ccgaagcggt caagcatcgc cattgtccgc tcagctccga atctgcgcat 2940301 caattcatct tccatagaaa gataaaattg agtaatcccc gggtctccct gacgtccgga 2940361 acgacctcga agctgattgt caatccggcg tgattcatgt cgttctgttc cgactacagc 2940421 gagcccgcca agctctttta caccttcgcc aagcttaatg tccgttccgc gccccgccat 2940481 gttagtcgca atcgtaactg cgcctttttg gccggcctct tcaatgatct gcgcttcacg 2940541 ttcatggttt ttggcattta acacttgatg cggaattcct ttgtttttaa gcagcttaga 2940601 aatcaattca gatgtttcaa cggcaaccgt accgactaga acaggctgtc ccgtcatgta 2940661 acgctgtgcg acatcctccg caactgcctt aaactttcct tccatcgtgc ggtaaattaa 2940721 atccgggcgg tcatcacgga caacaggcct gttggtaggg atcgtgacaa cctgcatgtt 2940781 gtagatgttg cggaattctt cttcctctgt cttagctgta cccgtcatac cggcaagttt 2940841 ttcgtacatt cggaagtagt tttggaacgt aatcgtcgcc aaggtcatgc tttcgttttg 2940901 aatctcaagc ccttcctttg cttcaatcgc ttggtgaagc ccctcactgt agcggcggcc 2940961 tttcatcaga cgtcccgtga aggaatcaac aataacaacc tgtccgtctt ccactacata 2941021 gtcaacgtcc ttttgcatcg caacgtgagc ttttaaggcc tggttgatat ggtggttgag 2941081 cgcgacatgc ttcacatcaa agaggttatc gatgccgaat gctttttccg ccttcgtcat 2941141 tccttcttca gtaagctgta cagcttttgt tttgatatcg tacgtgtaat ccttctccgc 2941201 ttttaacgtg cggacaaaag catttgcctg tacgtacagc ttagtggatt ttgcagcttg 2941261 tccagaaatg ataagcggtg ttcttgcttc atcaattaaa atagagtcaa cttcatctat 2941321 taccgcaaaa tgaagcgggc gctgaaccat ctgctcttta taaagaacca tattgtcacg 2941381 caaatagtcg aagccaagct cgttgtttgt ggagtaagta atatcagcgg cataagcttc 2941441 ccgtttttcg tcttttgaca ttgagtttaa attcaaaccg acagtcaaac cgagaaactc 2941501 gaaaattttc cccatttgct cagcgtcacg gcttgccaag tattcgttga cagtcacgac 2941561 gtgtacgcct ttaccggtta acgcatttaa ataaacaggc agggtagacg ttaatgtttt 2941621 cccttcccct gttttcattt ccgctatatt tccgtcatga agcgccacgc cccccatgag 2941681 ctggacttta aacggaaaca tgcctgttac gcggcgtgaa gcttctcgaa caacagcgaa 2941741 agcttcaaca agaagatcat ccgttgtcgc ccctttttca agacgctctt taaattcaat 2941801 tgttttatgt ttcaatgcgt cgtcagagag attttcatag tctccgcgaa tcgcatcaat 2941861 atcgttagca attttttcgt atctattcag cgtacgtttt gttggatcaa acattttatt 2941921 taaaattcca agcatttata acgctcctct atcatcacac gcctatttta gaggcatgta 2941981 taaataattt actagtccat gtatacctct cattatcata tcataccttt tgttatttcc 2942041 aaagaatttg caaataagaa aaacaaaaac cttccgcgga catcacggaa ggcttctctt 2942101 cattattcag tcggttcaat taagccatat ttcccgtcat ttctgcggta cacgacattt 2942161 gtaaggtttg tttccgcatt tgtgaaaaca aagaaattat ggccgagcat attcatttgc 2942221 aagatcgctt cttcactatc catcggcttt aaattaaagc gtttctgacg gacgatgtcc 2942281 aagctctcct cctcttctat gtcatcctga accgcaatat ctgtatcaga gccaagaccg 2942341 tttgccaata aatattttgg agagccctgc tcacggaatt tacggtttac tttcgtttta 2942401 tgcttacgga tttgacgttc cagtttgttt gttgcgagat caattgcgtt gtacatatcc 2942461 tcgttatgca cctcggaccg aagcgccaga tctgtcatcg gaatcgtaac ctcaacctta 2942521 gactccttgt cattgtaaaa cttcaagttg acgttcacat cagcatccac gctatggtca 2942581 aaatagcgct ccagcttgcc gatcttcctc tcgacatgat cctttaacgc gggtgtcact 2942641 tcaatatttt ctcctctgat gttatagttc atcaaagaac gcctcccttt tattaaggat 2942701 atgtatctat ttctctttta ccctttacaa ttcctgctga aacataaatc ttttgtgaaa 2942761 attcagtgaa ctttgtcgaa ttttgtttgt atttgctctg ttattggcgg ctgctaagct 2942821 tttgaatcaa acagtttcat tttgctactt ttcggcagct cagctttaat tgatttgctg 2942881 taattgaagt tattttcctt aggaaccagc atatcgtacg aaatagagat gaattgcagc 2942941 gcgtctcttg tcagctgcct attcatctca tttacttttt tcagacgtcc gagaacttga 2943001 gaaagagatt cgtatagttg ttccagctct tccttttcac tgcctgaggt tttggcgata 2943061 catgcggaaa tagtattatt ttcgctatat ccgagaaagg ccgaagttgt tttgatccgg 2943121 tcatcttctg tctgcgtgat tgcttgaata tatttttgct cttttgtcaa aatgttagaa 2943181 agctcttttg ttttgccggc tttgagcgct tccgtctttt cttcagacag cgtgagcagg 2943241 tgctcatgca gaacgcaaag tcgcttcaat tgttcaataa ttgccttcgc tgacatgggc 2943301 tttctccttt tttattgctt tttataaaaa ttaatcatat ttttcgcaat atgatttgcg 2943361 tctactttgt atgacccgtt ttcaatttgc gctttaagct gcgcaatttt ttcctgtcgt 2943421 gaaccagtga ctgcgtcgga tgcatgttgc atttctttag cctgtgatga aatttcaatt 2943481 ttatcttgag gttgtgcaac agttttttgc accgcttgct tatcataatt tttttgatat 2943541 ggattaacgg attgtgttcc aaattgattg attttcatag gattcctctc gctttccgtt 2943601 gcagtcttta aacaatctta acccttttat cgactgcgtt ttcagttagt ttagggaatc 2943661 agctgttttt ggtattatag gcatagtatg tgtctttttt actattttct ttctcgattt 2943721 tcagagcatc ctcgtggttc aaatgatcca tttgatcctt aatatcagac tggcaagcct 2943781 tgcagaactt gccttctcta atcgatgtcc cgcacctttc acaagggtat gccaaattag 2943841 gaagatgagt gatctgaatt cgcttctgcc tgatgaattt caatatcagc tcttcttcca 2943901 cacctgtttc ctcagttatc cggctcaaag ttgattgccg gttttcctgt tttcttaaaa 2943961 atttatagac agtctcaaat gatttttctt cttccttaat acacgcctga catacggttt 2944021 gcagctttgt ttttaaaaat aaagcattgc atttcggaca attagccagt tctcccatct 2944081 ttttttctcc ttattagata atatgcctgt gtcaatttct agtgattata tcggcataaa 2944141 aacagaatca tttagcttct gatcaaggta aaagatgaca ctgaagcggc ttttcctttt 2944201 tctaataagc agcgggctgc gaagtgcaag gtggcgcctg ttgtataaag atcgtctatt 2944261 aaaatgatat tcataccttc tgctgaatta ttttttgtat caaaaatgca ctctgacagc 2944321 aggcgttctg ttttcttttt ctttgactgt ttctcattat tcaggcgaat gaggggatgg 2944381 tgggaaggcc ggtctaaaca ttctgccaag agatgtgcct ggttaaatcc gcgctcttct 2944441 tcccgttcct tgctcagcgg aataggtaca agaacaaaat gcttatcggg gtaaacctta 2944501 gaaaaggttg aagaaaaatc acttttaaat gcatttatga tttctgcatc tcctctaaat 2944561 ttaaaacggg agagcgtttc tttcatcata tcattatatg tgtaaactga acggttttga 2944621 cgcaatagca aactgtctct gatccttgtt ctccacacct cgcaatccct gcatacggca 2944681 tgaacagatt gaggtctgcc gcacaggggg cagatatgtc ctgtgatttt ctttaatttg 2944741 cttctgcaag aataacaaac cttttcatca ggctttagta aaaaaagggc tctccatgta 2944801 acatcttgag aaaattgcga atcacataat aaacagatca gtttatgaat gcctcctcct 2944861 gcttcgtttg acataaatcg cttggactct ctgaaactac tgcagcagat tcagccaaaa 2944921 tgacaagcat tgctgtgttt ttttgtttat ctaccagctc agctttcgta tatgcgatct 2944981 ttttaaaatc agtaacgtag gatggactca ctttgtttaa agaaagtgcc aatacatcgt 2945041 tttggcatac ttggcaagta caggccatat gaagctggtc catatatcgg tcgagcagtt 2945101 ctttcattac gatttctttt gaattgacaa gcatttttac agctcctcat catcggttat 2945161 atgagtatac tgtaccacgt tttcaaataa tggctagtct gtacattcaa cttttgctgc 2945221 caattcattc atttctttta tatgctttct tgcatcgagc atactctttg ttttgccgaa 2945281 gtgaaagtaa atgacatcgc cgtccgcata ttctttatgc cggccggttc ttcctgcaat 2945341 ttgaacaagt gcgctttccg taaagataga cgattccgct cctagtacac ccgtttgcac 2945401 cttggggact gtgacgcctc tttccagtat tgttgttgtg attaatagat cgagctgacc 2945461 atctctgaat tgctgcactt tctcctttct atgcttgtct tccgcgtgca cagatgcggt 2945521 tcggcaatga acacctttaa agcacgcagc agccttttcc agaatagaaa cggaaggaac 2945581 gaataaaaaa acaggcctcc cttcttttac atgaaactct atccatcttt tcaccgctgg 2945641 cggaatttta tttcggttta atttcttctt ccagtttcca caccatacaa agcgcggttc 2945701 gggtaaaggt ttccggtggt gtcttgcggg gatgcgaact gaatgtaact gtccgttcag 2945761 tgcttttctt tttaattctt taggaggtgt tgcacttaaa taaacgaggg tgctgttttt 2945821 ctttcttgct ttttgaacag cgaattgaag ggtttgatca gcagaatatg gaaaagcgtc 2945881 aacttcatca atgatcataa catcgattgc atctttatat cgcaaaagct gatgcgtagt 2945941 ggaaatcata agcggagata gccgcccttt gtcatcgctt cctccgtaaa gcgctgaaat 2946001 gtcagcaccc tgaaaggcag ccttgagtct tggagcaagc tctaatacaa catcggtgcg 2946061 aggtgttgca atacatacac gcagtccttg atttaacgct gattctatac caggaaacag 2946121 catttctgtt ttgccagcgc cgcaaaccgc ccagatgagg agctcttctt tttttgatat 2946181 tgcttcaatt aaaacattgg cggctttttg ctgtccgctt gaaagcttgc catcccatgt 2946241 cagcttaata gacttccagt ttgattcatt ttcctctttc catgaatata aaggaacctc 2946301 ctcactcact ctgcccatca tgacacagga acggcaatac agcttattct ttccagatga 2946361 gtgataaaaa gaaaaatacc gctgatcagt ttgtccgcac ctattacatc tatatctccg 2946421 tttatttatg gatatagaat tttcagcagt gatatatcca ttcttgatat gccattcaat 2946481 catctcatcg gaaaatgaga gctcagtcct gagcaaatga cggcttcgaa gcgtctgctg 2946541 caattctttt gaaaaggaac tgtttttttc aactggcaca ttcacatagc acgcctcctt 2946601 tcgaaacagt atgcctgaat gaatattttc tgtccaacta ttaaaataag aatataaaaa 2946661 aatctccgct ctaaaaacgg agatttggcc ttatttaaaa caccagcaaa ttcctaacgc 2946721 accttcaccc aaatgagtgc cgattaccgc gccaaaatag ctgttataaa attcaacatg 2946781 aggatatttt gcagaaagct cttcaatgat tttcgctgct tcttcctctc gattagcgtg 2946841 gataacagca gctcgcatag gcaacccttt actcgcatct tcgtctaaaa gctcataaat 2946901 tcgcgaaatt gcttttttac gtgtgcgaat cttctcaaaa ggcacaatta ccttattgtc 2946961 aaaatgaagg ataggcttta cctttagaag actaccaatg aaggcttggg cgctgcttaa 2947021 tcgcccgccg cgctgaagat gggctaagtc atctaccata aaataagctc gaactgtttt 2947081 tttcatttct tccagttctt ttataatatc ttccggcgat gatgctccgt ttttgattaa 2947141 ttcagcagct ttaagggcat aaaagccttg agccaagcag ctgatctctg agtcaaatgg 2947201 atacacatca atattgtcga ccatcgaatc agccgctgct gcactgctga atgttccgct 2947261 gatcccgctg gaaagatgga tactgataac cgcatcataa gacttgccaa gctcttcata 2947321 caacgcaacc agctcgccga ttggcggctg agaagtcgtc gggagctcat tatgtttttt 2947381 cacttcttca taaaagcttt tccagtccaa ctcaatttct tcacggtaag tctcctccct 2947441 aaaaacaacc tggagaggga tcatatgtat ctgatgttgt tcacgcattt ctttcggaat 2947501 atatgccgtg ctgtctgtta cgactgcaat attcatagct tcgatacctg ccttattgct 2947561 ttataactct attgtaaggg aaacggcagc ctaaaaaaag acctgcctag taaaaggcaa 2947621 gtctcctatt atactatctc atttctaccc agccattttt aatggcgacc acaacggctt 2947681 gcgtccggtc gtttacattc attttttgta aaatattgct gacatggttt ttaacggttt 2947741 tctcactgat aaacaatgat tcaccaatac cgcggttgct ttttccgtct gcaagcatct 2947801 gcagcacttc acattcccgc ctagttaaaa tatgtaatgg tctgcggatt tcagggtaaa 2947861 cctcatgttg agggtgtgca gaaactccgc ttgttgcaag gcggcggaat tcgttaacga 2947921 ggttgtgagt aaccttcgga tggaggtaag atccgccctc agccactact ttaaccgctt 2947981 caattaatgt atcagcatcc atctctttca gcagataacc tcttgcacct gttttcaggg 2948041 catgtgttac ataattttcg tcatcgtgaa ttgatagaat aattacttta gattcaggat 2948101 acagctctac aagctgtttt gtagcttcca caccatttac gtttggcata ttgatatcca 2948161 tgatcacaac atcaggatga tagtgctcaa caatacgagc cgcttcgtcc ccgtcatcac 2948221 cttcggctac cacttcaaag gtaggttcaa aatccaatat ccgtttaaca ccttcacgaa 2948281 ataactgatg gtcgtcgata ataacaatgt ttactttagt cacaagccac gcctccttgt 2948341 attattgttc tatatactct agcattcggt caatatgcct tttggctcta ttttacaaat 2948401 catagtcaaa gagataacgg aaccttaatc ataataaatg tcccaagacc tattttcgaa 2948461 tctattgtca tcgttccttc caataaatct actctttctt tcatgcccag caagccgaat 2948521 gatttgtttt tcttctcttt cgcttccttc aggtcgaacc ctttaccgtt atcttttatc 2948581 attaaaatca caaaatcctt tgtgatctca actttgactg taatttcttc agattcagaa 2948641 tgctttagcg cattagacac agcttcctgt gcgagcctga agagcgcaac ctcaaactga 2948701 ggcgctagcc tctgatcctc tgtttctcca atgcactgaa aatgtatttt gaccttcccg 2948761 ttatattcct cggttgtata tagatatttt cttaaagttg gaatcaggcc taggtcatca 2948821 agggccatcg gtcttaaatc atatataatc cttctcactt cgtaaagggc attccgaaca 2948881 ttttggcgga gatttttaat ttcttggaat ccgtcctctg cgccccggtc acggaaaatc 2948941 cgctcgatta attccgatct catcataaca ttcgccagca tttgagcggg tccgtcatgg 2949001 atttctcttg agactctttt tcgctcttct tcctgcgcct caataattct taagccgaaa 2949061 tcctgttttg cctgagcatc agcaagaagc agtccaactt cgcgcaaatc ctgattcaag 2949121 tagttgagca caactgtaat ttggcttact aatgattctg accgctcaat gatttcctga 2949181 agccctagca atctgcgctc caaatcgtcc cgccgttcgc gcaattgctt ctcacgctgc 2949241 tggatcatcg tcaattctac ctgcagctta tgggcttttt cataagcatt gcggatttcc 2949301 tcttcactga atctatgaaa attacggctg acctcggata aacggtttct cgcatggcga 2949361 gtttgcactt caagtttatc gccaagctca atcacttcat acacctgctg tttaatttgt 2949421 ttcagttctt cgaccagctg ttcatactgc tggcgtgact gctccccgat ttgaaaaacc 2949481 tcgtccttgc tcccgtcaac ggttttcagc atcttcatca aaatagaatc cagcactttg 2949541 gaatccatct ttgttttatt cataatttcc ctccgtcacg gcgttgtcat atatttttat 2949601 tataaatgta attgatctgc aaattatgtc gaattataat gaaagaatgc gtatattcta 2949661 gaaaaaaaca tttttatata ctatctactc tttatgatac caaaatacgc acaaaaattc 2949721 taaagactgt acgaatttgt ataggcagtc ttttatgctt agcaggaggg tcagctagca 2949781 tgctgcacag ctattttact gtgaaagaag cgggagaaca cgagattgtt atagaaaaat 2949841 cgcgttttat ctgtcattta agccgtgttt ctaccgaaca agaggcacag gaatttatac 2949901 agaaaataaa gaaacagcac tggaatgcga ctcataattg ctcggcttat gttattggcg 2949961 agaatgatca tatccaaaaa gccaatgatg acggggaacc aagcggtaca gcgggagtgc 2950021 cgatgctcga ggttttaaaa aaacgcaggc tgaaggatac ttgcgccgtc gttacacgct 2950081 acttcggagg cattaagctt ggtgctggcg gattaattcg cgcttatggg aaatcagtgt 2950141 ctgaaggatt aaatcatata ggtgttgtag aacggaagct tatgcgaatc atgcatactt 2950201 ctgcagatta cacatggctt ggcaagattg aaaatgaatt aagggagtca caatttctgt 2950261 taaaggaaat ccattattca gaaaatgttg aattcgaaac atacgtggaa gaaaaagaaa 2950321 ccaacgcttt ttctgaatgg atgacagaac tgacaaatgg aaagagtgat attaaagagg 2950381 gagagttgac gtatcttgaa aaagccgtca atcacataaa ggagactgaa taatggctga 2950441 acgcgttaga gtgcgtgtgc gaaaaaagaa aaagagcaaa cgtaggaaaa ttttaaaaag 2950501 aataatgtta ttgttcgccc ttgcactatt ggtagttgta gggcttggcg ggtataaact 2950561 ttataaaacc attaacgctg cggatgaatc gtacgatgcc ctatcccgcg ggaataaatc 2950621 aaatcttcgc aacgaagttg tagacatgaa gaaaaaacca ttttctattt tatttatggg 2950681 aatagaggat tacgcgacta aaggacaaaa agggagatca gactctctta ttgttgttac 2950741 cctggatccc aaaaataaaa ccatgaaaat gctgagcatt ccgcgtgaca cacgtgtgca 2950801 attagctggt gacacaacgg gaagcaagac gaagatcaat gccgcttaca gcaaaggcgg 2950861 taaagatgaa acagttgaaa ctgttgaaaa cttcttgcaa atcccgatcg ataaatatgt 2950921 cacagttgat tttgacggat ttaaagatgt gattaatgaa gtcggcggta ttgatgttga 2950981 cgtgcctttc gatttcgatg aaaaaagtga tgtagacgaa agcaaacgga tttacttcaa 2951041 aaaaggcgag atgcatttga acggcgaaga agccttagca tatgcccgga tgagaaaaca 2951101 ggataaacgc ggagactttg gccgtaatga cagacaaaaa caaatcttaa acgcgctgat 2951161 tgaccgcatg tcaagtgcaa gcaacattgc taaaattgat aaaatcgcag aaaaagccag 2951221 cgaaaacgtt gaaaccaata ttcgcattac tgaaggttta gcgcttcagc agatttacag 2951281 cggctttacc agcaaaaaaa tcgacacatt gagcattaca ggttctgatt tgtatttagg 2951341 gcctaacaac acatattact ttgaacctga tgctacaaat ctcgagaaag tcagaaaaac 2951401 gcttcaagag catttagatt atactcctga tacaagcact ggcacttccg gtaccgaaga 2951461 cgggactgac agctcaagca gttctggcag cactggcagc actggcacaa caactgacgg 2951521 gacgacgaac ggaagcagct attcgaatga cagcagcaca agctcaaaca acagtacaac 2951581 gaattcaaca actgattcat cctattaaaa aatgcccggt ccttttagag gatcgggcat 2951641 ttttgcgcag aaaaaaactc cggcacataa gccggagttt ttaattcctt ttcaccagcc 2951701 gtttataaaa ctttgtaaac ggcttaaatt tttcattcac gagtcctgtc acttctgcta 2951761 tgatttgcat aaaaataatc aaaatgaaga taataaacaa agaaagccaa attgtggcac 2951821 ttttaagtac aatcgcactg atactgaaaa taaatccaat taaataaata actaagaccg 2951881 acatccgatg tgaaaggcca aaggccatca gtctatggtg aatatgcgac ttatcaggcg 2951941 ctgaaatcgg ctgtttgttt aatattcttc tgatgatagc aaatgttgta tcaaaaatcg 2952001 gtacgcctaa tataataatc gggataacga tactgaacaa tgtgacactt ttatacaggc 2952061 ctaataatga aagaatcgag atactatacc ctaaaaacag tgatcccgta tctcccataa 2952121 agatttttgc cggatggaag ttgtaaaaca aaaaccccag cgtgctggca ataacgacta 2952181 atgagagtga cagaatgagc acttttccgc cggatagcgc catgacagca atcgttgaca 2952241 ggccgataac agaaagaccg gcagcaaggc catccaatcc atcaatcagg ttaattgcgt 2952301 tcgtgatgcc gacaatccat aataccgtca gcggataagc catccatcct aactcaaatc 2952361 gttctgttaa aaaaggtact gagaaaaagt ccatttttaa gccagtgctt acaatcataa 2952421 tggctacacc taattgaatc aaaaacttaa cttttgcact taattgatat ttatcgtcaa 2952481 gaatacctaa cacaataatg atgaatgctc cgactgtaat tgccgtcatc cttgtttctg 2952541 tgtaaatacc ggatgcaagc acgcctgcaa ccaccccgat aaatatggcc agcccgccca 2952601 tgcggggcat gattttgtca tgtacttttc gattgctggg ctggtcaact gcacctattt 2952661 taatcgcaat cctttttacg attggggtta tgattaaaac tgtcagcagc gagacaataa 2952721 acgcaacaac aatgcgaatc atgcgttcgt caagcataaa gaagtctcct ttggaattaa 2952781 atgaagtctt tatttatata gagaaccgtt ccttccatta taccttctcc ttagttatta 2952841 taacaagctt catcaaaaag aaacacgtat aatcaaaaaa cgcgcatccc aatttatagg 2952901 actacgcatg tttttgaatc cctgtatatt tcataatttg tctaaataag caattccaat 2952961 cttgtgtccg ggcgatgttt cggcgcattt ctttataggt ctcgtctccg ttttgaccga 2953021 gaactttttc acaagcggct ataaaatcaa tcggatgatc gccctctaca tattcgtata 2953081 catacggctt ttgcattttt gaggttgacg gaagattagt gcctacaaca ggttttcctg 2953141 ccgctaaaaa ttcaaatagt ttcagcggaa acacagcttg attatacggt gattgtttat 2953201 atggcataat gccaatgtcg ataagctcca tataatgagg cacttctttt ggatctgccg 2953261 gaccggtcca tatgacattg ggaagcctca gcagctcttg aaacgaaaca tcaccattgg 2953321 tggcatccgg gccaacccat aaaaatgtcc aatcaggctt ttgcagtgcc gcttctttaa 2953381 tcattttaaa atcgagcttc ggtttaatcc cgccaataaa acctaacact attccttctc 2953441 tcccctgcag tatactgcga tcgggagctt gtttatttgc agaaaacagc tcatactcca 2953501 caccgttttc cacagtatga accttttctc gtcctgcagt cagttttttg tctacttcct 2953561 tgtgaagata atctgatgaa caggttattg aatctgctcg ttgtataatt ctcagctctg 2953621 ccgatttaat gacttttcgc cggaattcag acagcagatt tgatcggccg ctgatcggcg 2953681 cagcccatag gtcactgcag tcataaatga cctgatccca agaatacagc gaagacagca 2953741 gcgggaatcc gggaaacgtg taccataaac agcagcgttc accgtttgca gaagcaggtg 2953801 taagctcatc gagtaatggg gagagcttat gtctgtaaaa gacatctgta tatcgtccga 2953861 aacgaaacat ttttttctgc agcaggtctt tgacagcgaa ttgcctgatg ccagaatgga 2953921 cttcctgaaa ctctttccct tgggcacgcg gagccggaca tacccaaata acttccttcg 2953981 tttcctcctg agcagctaaa aattctgcca gccggtgcct tctgtatctc aattggtctt 2954041 ttccccattc agcagtggca acgatgacat gaatgattgc ttcttttgtt tccaccttca 2954101 tcaccttttc tctctgtttg cagctataat ctttttttca ccgcgttttt tgcatattga 2954161 acaaaacacc atgttgcttt cataaaatga agccgttcga tctccctgta gacaaaccac 2954221 gtttttttcg cagccttcca tttgttgctg gaaattgaat tattgacaag ccgatattca 2954281 gccaggcatt cattcattcc ataggcagta aatccttttt ttaaaagaga cagccatgtg 2954341 gctaagtcct gtctcgttct gatattcggc atttggatct gtcccgtttg ctccctgtca 2954401 atcatcaccg tcaagcagcc gataattgta tttttcaggg cgtcatcgta cgtcaggctt 2954461 tccggcgcat gaataaattt atcgagcggg gtcccgtcct gcgccattaa gctgtagccc 2954521 gtgaaagaga acgcacagga gcgctccatc ataaactcaa gctgcttttc cagtttgtct 2954581 tttttccatt tgtcatcact gtccaaaaat gctacgtagc gcccttgagc gcgttccaac 2954641 gctttgttgc gagcaaccgc agctccggag ttctcttcca gatacaccac atgaattctt 2954701 tcgtctattt tttcatactg ctgtaaaatg tcgcgggtcc catccgttga gcaatcatcc 2954761 acgataatca tttcccaatg aggatggctc tgatctaata ccgaatgaac cgtgtcttca 2954821 atatagtcac gcgcattata ggaaggtgta atgacagata cgagaggttt ccaattggtc 2954881 atgatcacat ctccatcgta tgattttaaa aggattctct gaaaaattca ggaatgacaa 2954941 cgaacataaa ggcaatcgta aggccaatca taacgccgag aactgctttc tttttcggag 2955001 acataccgcc gcctgctgtc tcacttacgg tttcggaatc agtaacactt gccgctttca 2955061 ggttaagctg tgtgtttttg agttcatata aaaatctctc tttatccact ttggaatcct 2955121 cgctcaccga ctcgccttca agcgcgtcta tgctgctgcg gatgacggct tctctttctg 2955181 catacagctt ttgatcgttt ttgaggaagg tggaggatat ggcgtttaag acagattccg 2955241 ttctatcctt atcctcgtca ctatagctta aagtcagtaa cgatttggat tccgtattga 2955301 ttgtaagctt ctctttgatc tctgctacat cttcatcctt ttcatcagga agcgcctcct 2955361 tcaaaaagga gtcgctcttt aatagaagcg gaatctcttc tgtgctgtta taaaccggat 2955421 gatcatagct ccccacagcc aaagtatctt cagctgtata gctcttttga tcagcgatct 2955481 gtgacggcag gatatacccc gccgcaccta atataattgg caccgctatg atccaaatga 2955541 tatttttttt tatgcgacgg gctattctta tcaatatatc gttcatataa gtctccctgc 2955601 tttttgtagt ctgtttatct gtacatcggc tcaggcattt gtctggatcg ccttaacaca 2955661 ttcacggcgg cgatgacgag cgccataaac acccaatgga aaaataaatt tgaaacagag 2955721 cttgggctga tacttgatac caggaaactg accatagcgg taataagtcc ttctgtgatc 2955781 agttttgact gattttctaa ttttctttca taaaacttgt aaagcaccca tatgaggtag 2955841 gcataaacgg acaaatatcc cagcatgatg aacaaaccaa aattagcaag aatttcaaca 2955901 agccagttat gcacctctgc cacattgtca gtatcatata cagcataatg ctcaagataa 2955961 taggatacat ttcctgcccc gactccgaat ccgtatgaat caaggaaaaa atgccaagcg 2956021 tttttcagca gatttgcccg agccacattt gatggaagcc tgtcatgaaa tgaatgcagc 2956081 gtctgcgggg ccagaaacag ctcccaaaac tttgaataga ttttgctggc gaaaagaact 2956141 gcgaaaagag caattcccgc cgccgacagc catatagcca ttctctttaa aacaggcggc 2956201 aatacaatga agatgtagac agcaatacct gcaaaaatgc ccagaaggct ggctcttgaa 2956261 ccagtggcaa aaattaaata caacgcacag agcgagagca caaggccaat tgccttgatg 2956321 tatccattct taatgttttt catcatcgtg atgtaaaaaa agaagctgat ggataaaaag 2956381 gtcgcaaagt cattttgatt aaaaaagacc gatgtcggat aatgctgctt gtactccggt 2956441 ccgctgtaca atgtggaact cgcaagatga tggtgggtga tatgattgta aaaaccaatg 2956501 atcatcagaa ataccgtcat caccagccaa atggcataaa caatcatcag ccgctccatt 2956561 ttttgcacgt acatgacaat aagataaatg aagaagatcc ccattgccaa taaggctaaa 2956621 tacttgaggc caactgttac cgacttggcc cacagcagag aaacaaggcc atatataaac 2956681 caaaaggcga aaaagagtaa aatccctttt acttgcagcc catgccatct ttcaatatgg 2956741 gttcgattcc gaaccatgcc gaaaatatga aggcaacccg ctgcaatgag cagaagccgg 2956801 taaaggaaca aactgaaaaa tccaagatga atggcaaaaa atgcattatt taaaaaagtg 2956861 caggcgatca aaatatagat tacagccata aagagccgtt cttttgttgt aaatgcggtt 2956921 gcaagcgtca gtaaaaacag gccaattgcc aacaccgcaa gcacagcagc catctgcatg 2956981 aaacctatat ctttatggat ggctcccagc aataggacga ctccaaatat agcagcggcc 2957041 agtaacgcta gcgtatggac cgctgatcgt ttgatactca catgtttaac ccctttcctg 2957101 atgtttcagg agccggcggc cgagcctagc agccggcagc ttcaaccaag taacactttt 2957161 tctttttata aattgacgct tcccaagtct ttagccaatt cttcaagcgg caagcccgga 2957221 aaatacttgt cagagggttc cgttccccga acagcgggac ggccgataga gtgataaatg 2957281 tatccggctg cctgcatctc ttcaagtgaa aataaatttc tgccgtcaat gatgactggc 2957341 tgttttaaga gggttttcac ttttacaagc tccatttctt tcacttccgg ccaatccgtt 2957401 aaaatcaggc atgcatcagt gtcttccatc gcagcataca catctgtgta atactcgacc 2957461 tgttcgccaa ggatcgctga agcttcagga atagcaatcg gatcgtatgc ttttacatgg 2957521 gcgcccagct gctgcagcat tgggataata tcaagcgctg gagcggatct cacatcgttc 2957581 gtattcggtt tgaaggctaa tcccaggact gaaatggttc tccctttgac gcttcccata 2957641 acagtcaaaa gtttatctac aatatgaaca cgctgctttt cgttcgtttc aatgacagct 2957701 tcgatgagct tgaatggata gcctgccgat tttgcgattt gaagcagcgc ggttgtatcc 2957761 tttggaaaac atgaaccgcc gaatccaata ccagctttaa ggaactttct gccgatacgg 2957821 ctgtcaagac caacaccatc agcaactttt gaaacgtctg cgccgactcg ctcacaaatg 2957881 tttgcgatat cgttgataaa ggaaatcttt gtcgccagaa atgcattcgc ggcgtattta 2957941 atcatttctg cactttctag gtttgtttta atgacaggag catggaatgg ctgatgaagt 2958001 tcctcaatga tggcagcggc tttatgactt gttgaaccaa tcacggcacg ctccatattc 2958061 atcgtgtcat gaatcgctga cccttcccga aggaattcag ggttagatac aacatcaaat 2958121 gagtatctcc cctttgaggc tttttgaacg atagattgca ccagtttccc tgttccaacc 2958181 gggactgtgc ttttatttac gatcactttg tagccgttaa gatgctcacc gattgttttc 2958241 gccgccgctt tgacgtacgt taaatcagct tcacctgttt tggacatagg cgttccgact 2958301 gcaatataaa taatatctga ggcccgaatg gcagacggga tatcgttcgt aaaggtcagg 2958361 cgctgatcca gcacattttt ttcaactaag tctgcaagcc ctggttcata gattgggatt 2958421 accccatttt tcaggcttct gatttttgat tcatcgatat cacagcaaac aactttattg 2958481 ccgatctccg caaagcaagt gcctgatacg agtcctacat aacctgttcc aatgacagct 2958541 atttttttca cagcgctcaa ccctctcctg taaaatgatc ttccaattta taatggtcgc 2958601 agtgtcttac gattaaacgg acgttttcgt gaccgtctga tactgatgat gcaaggcctt 2958661 ggcgtttttt cctgcgtcaa attgagcctg cacggtttca tacaagtcat ctgctacttc 2958721 cggcttccat atttgctcat gttcgtaccg agtgatcgct tccgccaagg cttgagcgga 2958781 tttcggttta atcagcagat gttggtgctt tccgaataaa gacgacactc cgccaacatc 2958841 cgtacaaata acaggaaccc ttagcgccag cgcctcaatc acaacagtcg gcatcccctc 2958901 actgtaagaa ggaagtacga atagatctgc cgcaagtaaa tagtctctta cctgatgatt 2958961 cgggacttgg cctgtgacga tatgcccctt ctgcgtcagc gtcgattttg cgggaccatc 2959021 cccgacaaag actgccttag gagagtcctg cagcgattcg atcgcttcag acagttcaaa 2959081 aatgcctttc tctctgacca gccggccgac atagacagcc agacgctgat cgagcgggag 2959141 tccgagtctt tttctgattt cctctttcgt ctcctcattc ccctgaaaac ggctgagctg 2959201 tatgccgatt ggcaaaaccg agctgtcaaa gcccgaaagc tttttggctt cttcctgaag 2959261 cttgtggctg actgctaaaa caactgacgc agaacctacg gcacgcttga aggctttaaa 2959321 cgcacctttg ctgtaatgcg gatagacatt cacatcactg ccatgcaagg tcaggacata 2959381 aggaatttgc gctgactctg acacgactgc cgcagccccg cccgatggca tggcaaaatg 2959441 cgcatggatc agatccggat ataggtcgcg ctgtttcatt gtttttaaaa cggctgatgc 2959501 gattctccga tgaggctgcg cccacttcag ctggccggga actgcccgat agaaaggccg 2959561 gtaaaccggt atcccctttc taatctcata ctccggtctg acatcctttt ttcgatatgt 2959621 ctttttcagc atgcggacag gtgctgaatg aaaaggccgt gggcatatca cagtgatatc 2959681 aagcccgagt ttttgcagct cttgcacctg tgtctcatga aacacaccct ctccgggttt 2959741 catactgctc ggatatacgc ttgtgatcca caaaatcttc atgacaaacg tccttttctt 2959801 agtagtttgc ttttcgtttg agggtacgct tttaccaaaa gaaagagata gcacagcgcc 2959861 ccagccgcaa ctgaaatggc cagccgcatt tctgcctgca tactgaagtg ttcggtactg 2959921 aggcttacac caaacgcgat gatgcccatc gccgcagtaa tcagaaatgg cttcataatc 2959981 gactggaaat aagctgaaag gttaagcttg atgacatatg ccaaaagcca gcgcccaatc 2960041 aggaaattaa caacgctgat aatggcatac acccatgcga ctgtcagcag gcttcccgtc 2960101 tgtacagctg caaacagtga taatccgtac agcagcagca cgccggaatc ccaataaaac 2960161 gctaagtcag ctcttccttt agccagcaac acagatccat ttggattcat gagcactctt 2960221 agtattccga caatcgcaag aacatttagg atcggaacag cagcaagcca tttttctccg 2960281 aaaaccgctg tgataaaggc gtctgacaca gacacgagcc cgattaacag cggaaacgaa 2960341 acaagcgcca gcatttttgt catattcaga aagccttctc tgatcacgct gttttcatat 2960401 ttgttttttg cgaaaatagg gaatgccacc cgtgtgacaa tcggattgat cttcaaaacc 2960461 ggaatggtga caatctgata agcgaggtta taaatcccca atgcttcagc accaataaac 2960521 cggccgatca aaatcatgtc gatatttgct cccagcctgt tcacaagacg ggatgaaagc 2960581 tgaaaggctc caaaagaaaa gaaatccttc atgcctctca aatcaaaaac aaaagcagga 2960641 tgccactttt ttcggtatac agcccaatat aaaatccctt tactggactg cagcaggact 2960701 tgagaaatca cgtacgccaa aatcgcatcc atcataaaaa ccgctatcgc taaatatccg 2960761 aatgacaata catttgaaaa aatctctatt ttgcttaacg tattaaaatg cagctgcttt 2960821 tgcagcatat actgatattg ctgtccaatt ggcgcgatca aaaacataat cgccagaatc 2960881 cgaaccagaa acaccagctc ttctctttga taaaatcccg caatgacagg actgctcaca 2960941 tataaaagaa caaacagcaa aacgcccgtc ataatgttaa gccaatacaa tgttgacagc 2961001 tggcgctccg tcgcgtcgtc tctctgaatt aatgctgcgc caaaacccat atcgagcaca 2961061 atctgggcga aaactgtaac cgttgtgatc atgccgacaa gcccaaattc tgttaaggtc 2961121 atcatatttc caagcagggc aaactgaaca atttgtatga ttgtaataca catggttgaa 2961181 atacttgtcc actttgcacc gctcatgatt tgttttgtaa tacttggcat catattccct 2961241 acttcttttt aagctcagat tgatggtgaa taatggaatc ccgttttatc ttgcaccatc 2961301 acccgtccaa actactttac aagtttttaa cataattttt aattctaaag tgaaagtcag 2961361 attgcgaatg taatataaat caaatatcag cttttccttc ggcgtcatat cgtaaccgcc 2961421 gttcacctga gcccagacgc tgtgtaaagc ctggaatctc attctggaat ttttccgtaa 2961481 atacgggccg ttccggacga gggccaatca tactcatatc gcctttcagc acattaaaca 2961541 gctgaggaag ctcgtcaatt ctcgttcttc tgataaaagc tccgatcctt gtcacccgcg 2961601 gatcttgctt ctgtgcccaa accgccccag acttctcggc atctattttc atggaacgaa 2961661 gcttataaag cttaaatggc ttcccgcctt tccctacgcg ttcctgcgta taaatggcag 2961721 gccccggcgt ctccaaacaa atcaaaattg aaaataccgc aatcattggc agcgcaatcg 2961781 ccaatccaat gagcgcaaac caaatatcca ttacgcgctt tattgccaaa taacgagccg 2961841 tcttttcaga taatgtaaaa gaatgtattt gttgaactga gaattcacga ctcacattca 2961901 tgcttttctc tgcactcact gacacacacc tcacgatttg tttgggatgt tatgatgacc 2961961 tatgccagtc agtttagcag acggatgtta attggatgta aatggtatgt taagaagtgt 2962021 gaattacgtg ttttttctga taaatgttgt taatactctt ttactatttt atatacaagt 2962081 cctatttgtt ttaatcattt catataaaaa agagacaaat ctgtgattag atttgtctct 2962141 ttcgattatc tgtaataaga tactgtgccg tcatgaatag cttgtgcagc tttatcttta 2962201 taaaccgctt gcttcaattt acttgcatct gatgcattag tgataaaggc agtttcaact 2962261 aaaacactcg gcattttaga atatttaata acatagaaag cagctgtttt tactccccgg 2962321 tctctcgttc caagattagc cgctaacttt ggttgaattt gttcagccag tctcttgcta 2962381 tttgcagctt gatatgttgt atcgtagtac gtctcacttc catttggtga tgagctatca 2962441 ttagcatttg catgtatact gagaaataaa tctgcttgtg cagaagctgc tttatttact 2962501 ctctcctgta aagaataaaa agtatcatta gatcttgaca gtactggaag agcacctgaa 2962561 gcatttagct ttgtattgac tcttttcgct atatcaaggt tgacttcttt ctcaaggagt 2962621 ccattgccga ttgctcctga atcttgatca ccgtgacccg gatcaataaa gattgtttca 2962681 cctacaactg gattctttag ctgattagca acctttgtgc ttacggcagg agtgtttccg 2962741 ataatcataa agtttgacat gtttttactt ccaataattt tacgggctcc tgtagataaa 2962801 ttttcaccat ttgtaagaat aagagattgc ttcttcttag ctgccagtgt agctcctgca 2962861 atagagtcag ggtagctgaa tccattgctt acatatacgg tgcttgttga taaattaagt 2962921 ttttgtacga tatttgcagc aagctcatat ctgtttgaac cgctaattct tgtaggagaa 2962981 ggtaacttgt tgtataccgt attgctgata cttccagtgc ctcctacaac aacggtactc 2963041 gaaattccct tatcttttat cacagacgta gtcgcactat ttatagatgt tttatttgta 2963101 aaaagaattg gatacccgtt tttcgctgca taagggatga cggccggagc gtctgcatat 2963161 aagaagccgt tcaaaataac agcttttgaa gtcgcaccca tcgcttttgc cacccgtgca 2963221 gccgtatcat aacggttgct tcctgcaatt cgtttaatac ttatccccaa gcttttaatc 2963281 tggttagcag tgttagaaga aacagcaggt gttccgccta caataattac atttttagtc 2963341 tgcatctctt tcaatcttgt tttcgtttca tatgaaagct tatcagaatt agtgtaaagc 2963401 aatggcgcat tcttctggta agcaagaggt gctgctgaaa tagcatctgc ataggaactc 2963461 ccaccaacaa ttacagctgt acttgctgtt gaatacattt gctttgatat ttgtacagca 2963521 gtgccgtatc tattgcttcc cccaactctt ttcactgagt tatcggccaa agctgttggc 2963581 acaaaaagta tgagccccag aaaacacatt gttaggactt ttatataaga acgcaattga 2963641 tttcctcctt aaatggcgtt atatcctaaa ataatcaata acttgtcaga gttgtacctg 2963701 gatagtaaaa tttcaaaatt gaactatatg aatctccagc ttctgctctt gcttttgctc 2963761 catattgact cattccgatc ccgtgaccat atcctttacc gctgattgtg tactttgaag 2963821 tatctttttt tacagtcaca taagtacttt taaatacagt cgctccaatc attgttctta 2963881 actcacttgt tggtacacta atggttgtaa ttttgctcaa gttataggag ccagtactgc 2963941 ttttaacaaa atacttcact ttcatcgatg ctgtttttgc acgctgccct tgtgtcgttc 2964001 cactaaagct taaatcgtca atacttgcaa ttttgacaga atcagcgctt gtttctttat 2964061 ttttcaagat ccagttctta actccggaaa gtcttgcaga atcagtttca gtcgctgaag 2964121 accaccaaga agaaggcttc gttaagtcca aagatttcgt atctagctgt tgttttgaca 2964181 aagtaagcgt ccagcctatt tgaggatcct ttgtatcttt ttttgcaatc aagtaaggta 2964241 cacttgacga ccacacttca ttactagctt ctgtgtaacc accattactg gaagaataag 2964301 ctgcagttat aagagatcca ttatatttca gaactttccc cttcgtttgc tctaccgctt 2964361 tattggtatt cgaattccaa ctgtagccac cataaacttg aaaagcggtt gtatcaggta 2964421 cagtagttcc tgtttttgtt attgagtagg ttcttgcagc gacagtctgt gctttaagag 2964481 cctcaagtga ccagctagca ggcatttcat tcggaattac tccttttaag taatcctcaa 2964541 atggaatatt ctcatttacc ggtcggatat atttagtaga ctcaatagag aaattaaccg 2964601 tgccaagata ctgctttcca tcaagactaa ttctgtttga agtagaatag ttttctggtt 2964661 taattcttag ggagtttccg taagttttga tgttttcaag gtttaatttt ccgctgttga 2964721 tttttagatt ataggtgcca ccgtcagcta aataaaattc atcagcaagt gaattctcaa 2964781 cttcagcaga aattgaactg gtacttccaa taaagtcgta tgcatatgtg gctttatctt 2964841 tcgttatact tttagccgca gccggaacgc tatcttgttt aacaaataaa atttggctgt 2964901 ttttcttcga ggcaagcgaa gcgcctatca atacgtctgc atattttgtc ccgttcgtca 2964961 ttacgacttt atcagccttc aactttagtt gcttaattat atttgccgta agttcatatc 2965021 tggttgatcc aggaatcctt tgcacagttg aagttttttt aatttggttt tctacactat 2965081 cactgacgct aaatgaactg cctataatga tgacttgttt tggcaaatca taatccggaa 2965141 gcttgtcttt ctctgtaagc aaaatagggt atccgtgtgc tgctgcatat ggagcaatgg 2965201 ctaaagcgtc ttgaaatact cttccggtta caacgatcgc tttatcatag ctgcccattt 2965261 gctttgcaat attttctgat aagacatatc tattttttcc gcttatcctt ttcacagcgc 2965321 catatgattt cagcttgttt tctacgtctt ttgaaatgct tcgcgctccc ccaatgatta 2965381 aaatattatc agggttaaac ttagcaattt gtctttcagt agtttttgtt aacgtgtcag 2965441 gctgagtaaa taaaactggt gcgttcagtt ttttcgccaa tggaataaca ggcaatgcat 2965501 caataaaaat atctcggttc accaatatca ctgtattagg atttttccac tggctgttgg 2965561 atgcaagagt cgcagtttcg tatcgtgaag cgcctgcaaa acgatccgta acagcaacat 2965621 tatctccagt tactttataa aatcctgttg gcgatagact gatgctagat ttatttccaa 2965681 tataatttaa caatttaact gagatgtttg agtctgctgc aaaagaaact gatggaatca 2965741 ataataagat tgcagcaagt gaacacacta tcaattgttt gcaagatttc aaaatttcag 2965801 gttcctccct atatcttagt tggcacgttc aatatctttt aacagaagct gaccctcatc 2965861 atttttttca tatgtaatcg tgaccttatc tccactgtta aacttatcaa gatcacttgt 2965921 cgattcttca gtgatatcaa gactaaccgg ctcattatct actgttactt ctattgtatg 2965981 agtatcagct aaccctacat aagtaccttc ttttgtttca atgttactgt ctggcgatac 2966041 atcttcacct tgactctttt gactattaac cccgcaaccc gaaagaagca atataaagaa 2966101 cagtaaagca ataaattttt tcattttttt cacctcatta tattttatcg tcaacctatt 2966161 ttatatttta aagaaaaatt aagaaacaat gaaacttttt tttataaaaa acgactattt 2966221 taggatttca ttcttgtatt aaatagagtt gtatttattg gaaatttaac tcataatgaa 2966281 agtaatttaa cagacgaggt gcaaaggatg agaaacgaac gcagaaaaaa gaaaaaaact 2966341 ttattactga caattttaac gataatcgga cttcttgtac tcggaactgg cggctatgca 2966401 tactacttat ggcataaagc agcttcaacc gtggcaagta ttcatgaaag cattgataaa 2966461 tctaaaaaga gggataaaga ggtcagtatc aataaaaaag atcctttttc cgtcttaatc 2966521 atgggtgtgg atgaacgcga cggcgataag ggccgtgccg atacgctcat ttatatgacc 2966581 gttaacccaa aaacgaatac aaccgacatg gtcagcattc cgcgtgacac gtatacaaaa 2966641 attatcggaa aaggcacaat ggataaaatc aaccattcat acgctttcgg cggcacacag 2966701 atgacggtag acactgttga gaacttcctc gatgttccgg ttgattattt tgtgaaagtg 2966761 aacatggaaa gctttagaga cgttgttgat acacttggcg gcattacagt taacagcaca 2966821 ttcgcgttca gttatgacgg ttattcgttc ggcaaaggag aaatcacgct gaacggaaaa 2966881 gaagcgctcg cttatacccg gatgagaaaa gaagatccga gaggcgactt cggacgccag 2966941 gaccgccagc gccaagtcat ccaaggtatt attaataaag gcgctaatat ttcttccatc 2967001 acgaaattcg gagatatgtt taaagttgtt gaaaataatg tgaaaacgaa cttgaccttc 2967061 gataacatgt gggatatcca gtccgattac aaaggtgcgc ggaaacatat taaacagcac 2967121 gaactaaaag gtacaggcac gaaaatcaat ggaatttact actaccaagc tgatgaaagc 2967181 gccctttccg atattacaaa agagctgaag gaaagcctcg aaaagtaaaa caaaaagaag 2967241 cttcgcacaa tgtgcaaagc ttctttttta tttgcctgta aatgaatccg gttgttcttt 2967301 tcgatacccg taatgaaaca gcaattcttc cacaatccgg cgggaagcct ctccatctcc 2967361 atacggatta gaagcctggg acattttctt gtactcatca ggatcagtta acagctgttt 2967421 tgcaagctga taaatgtttt cctcatccgt acctgcaagt ttcagcgttc ccgcttccac 2967481 tccttcaggc cgttccgtcg tatcacgcag aacaagaacc ggtttcccga gagatggggc 2967541 ttcctcctgc acgccgcccg aatcggtcaa tataaaatgc gatttcgctg caaagttatg 2967601 gaaatcgatc acctctaaag gttcaatcag atgcactctg tcagaatcac caaaatgctt 2967661 atgagccgct tcccggacaa caggattcag gtgcacaggg taaacgactt gtacatcttc 2967721 aaattcccct acaattctgc ggatggcctt aaacatgttt tccattggct cacccaaatt 2967781 ttcccggcgg tgagcggtca agagaatcat tttatcctca cccacctgat cgagaacagg 2967841 atgtgagtaa ccatccctaa ccgttgtgtt gagtgcgtca atcgctgtat tgcccgttac 2967901 aaaaatagag tcggcctttt tgttttcttt taataaattg tctttcgcct ggcctgtcgg 2967961 agcaaaatgc aaatcagcaa tcgcccctgt catctgtcga ttgagctctt ccggaaacgg 2968021 ggaatactta ttccctgtac ggagccccgc ctccacatga ccgacagcaa tttgatggta 2968081 aaaagcggct aggcttccgg caaacgtcgt cgtcgtatca ccatggacaa gcacaatatc 2968141 gggtttgata tctttaaaca actcatccaa tcttacaagt gcgttagacg taatctctgc 2968201 cagtgtctgc cgctccttca taatgttcaa atcgaagtca ggcttgatgt gaaacgcatc 2968261 taacacctga tcgagcatct gtctgtgctg tgcagttacc gttacatagg aatctatttc 2968321 aggatatttt ttcaattcaa gcacaagcgg tgccatcttg atcgcttcag gcctggtccc 2968381 gaaaacggtc atcactttta gttttttcat atttgtcacc tggttttctg ctatagtaaa 2968441 taaattcata ctacatattc tacatgaaaa tgcatcattt taaatcattt cattcttgat 2968501 tcaaataaaa tgatataagt tttaatatta aggataaagc ttgtttaaaa atggtttatc 2968561 cgatatcata aaaatgtgta aaaacatatt gaaaagggta aatagagaat agtttaacca 2968621 taaatttttt cgatcataag gaaggtgcct tttaaatgaa aaaagtacgt aaagccataa 2968681 ttccagcagc aggcttagga acacgttttc ttccggctac gaaagcaatg ccgaaagaaa 2968741 tgcttcctat cgttgataaa cctaccattc aatacataat tgaagaagct gttgaagccg 2968801 gtattgaaga tattattatc gtaacaggaa aaagcaagcg tgcgattgag gatcattttg 2968861 attactctcc tgagcttgaa agaaacctag aagaaaaagg aaaaactgag ctgcttgaaa 2968921 aagtgaaaaa ggcttctaac ctggctgaca ttcactatat ccgccaaaaa gaacctaaag 2968981 gtctcggaca tgctgtctgg tgcgcacgca actttatcgg cgatgagccg tttgcggtac 2969041 tgcttggtga cgatattgtt caggctgaaa ctccagggtt gcgccaatta atggatgaat 2969101 atgaaaaaac actttcttct attatcggtg ttcagcaggt gcccgaagaa gaaacacacc 2969161 gctacggcat tattgacccg ctgacaagtg aaggccgccg ttatcaggtg aaaaacttcg 2969221 ttgaaaaacc gcctaaaggc acagcacctt ctaatcttgc catcttaggc cgttacgtat 2969281 tcacgcctga gatcttcatg tatttagaag agcagcaggt tggcgccggc ggagaaattc 2969341 agctcacaga cgccattcaa aagctgaatg aaattcaaag agtgtttgct tacgattttg 2969401 aaggcaagcg ttatgatgtt ggtgaaaagc tcggctttat cacaacaact cttgaatttg 2969461 cgatgcagga taaagagctt cgcgatcagc tcgttccatt tatggaaggt ttactaaaca 2969521 aagaagaaat ctaaacaaaa aggctattgg acattcatcc aatagccttt ttttatttca 2969581 acatcaaagt caatgtatgc tcttcattat caactgcgaa gacctgatca acggcctgcc 2969641 gcaaaaatta ataatcccag acaaacacac tgattgtaga gttaaacaaa ctaaatgaaa 2969701 acataaatac aaacatgcag attaaatagt aaatatcttg tattcaatgc aagctaagta 2969761 aacaccactt gctaaaagaa caatgactaa acaaccagca ttacaaaata attaaataaa 2969821 tttgaagcaa ttacaacaga aggcagtgaa ctgtcggaaa gttcattttg gctaccatat 2969881 taatcccttt aactacgctg ttggatttat caagaattgt cgggctaata gaaaaccacg 2969941 gaatcaaacc agccagcatt caaacgataa aaggcacttc tccgatacct gttatgacca 2970001 gcttactgtt gcgcatccca aatacaaacc agtacgccat cattagaata aggggattta 2970061 aaacctgcca taatacacca aaataattga ttttttggat ctttcggtta aagaaattta 2970121 aaagtaccag tgaatattgt aacaaatgtt gagttttttt cacttttaaa aagtaaagag 2970181 aagtctcgca gaacttctcc caacatttga agtgtcaata taaaacaaac caacctcatt 2970241 tagcaacttt attattatct aattccaaaa tagcattata aatacgattc ctattatttt 2970301 tatcagtata tgcaaaaaag ttatctactc tttttctata cttatcttcc atacgactat 2970361 tgtttttcat ataatagata actttatcca ctaagctatt atgattttct aatacatcac 2970421 caaaccccat ttttttataa tcataataat caagtttaaa atggtatgac ttttcgtatt 2970481 gataataaat aacaggtttt ttctcatatg caaaatcaaa cgcaacagat gaaaaatcag 2970541 taatcattat attagaagaa ttaaatagca tttgatagct gctgttatag tcggcaaact 2970601 ccacataatc atgcttttca aagtctacaa tctgttgctg aatatctggg tgaggaaaaa 2970661 aagttatttt ataattattt ttcttagcaa attcgattag ccgttcatca ttaatcaaag 2970721 cattatacct agaaaaatat tcactatctt taaatttcgg gttgtacggt cttactcctt 2970781 ttgcctgatc tttcggtaat acaatatctt ttctccaagt cggcattatt agaagttgct 2970841 tttctccctc actcttctta agattatcgt atctcggaaa tccacccaac aaaatattct 2970901 cttttttata gttgtaattc cctttcacaa tagaccgata ttcaggtttg gcagaagtga 2970961 ctaataattt gatattcttg ttgtatttgt ttaaccattc agaatgatct gccattgtta 2971021 ttccgtgctg taaaaagata aactcaaagt taaataaatc tctaaaataa atctccatat 2971081 taaaaaatgg atttacaacc catatatctg catgtgtcga tattactttg gaagaggata 2971141 aggttaaaat tttatgtcta aaagatctgt atggtatgac ctttccatat tttttgattc 2971201 tgtcgtaatc cttgctatct ttttttatta taaagtattt ttttacccca tcattcttgt 2971261 tgattgcata tttaaagagg tgctcggcat tatcatcagc tttgtcttgt ctgtctatga 2971321 ataaccatac tggttttcta ttaaaaatag tgaaaacatg gtgtaccatt cttgccatca 2971381 gtgccttctt aatcgctgat tttcgttttt ttgatttttc ccctgattta tgtagggatt 2971441 ttaagaaacg aaactctttt ataaatctat ttttaaaatt gttttttttg aacattaatt 2971501 ttttataatt ataataaaaa atataatctt ttttagccac ataagtatta tataaatcgt 2971561 ttgacaaacc tgaatacttg aaaaaacgaa gttttgtcaa cttccttttt ttacccttag 2971621 ttataaaaaa ctcaatatga tgattatctg ctagatgacc tttgggaata tctattgaaa 2971681 aaccgggata tttttttatt acttctccta aacttatata atcattatgc tgtcttttta 2971741 tattctttgc ttttattttt gtttcgccaa ttttagcata aaacttaaaa cctttagaat 2971801 taaacagcga gctccaaaag ccttctatgt gaatggaatc ctcattttct tctaaaattt 2971861 caatagttaa agtttgatcc gataatttcg aaacaatttt accttctctg tataaataat 2971921 aatcctgttc agtttctctt tcatatacat acctactata attttcaccg tgctttattt 2971981 ttaaagcatg atataaatag aaatggctga cactttttgt ttcaatgatg acatcgtcgt 2972041 caatatacga caatacttct cgaatcaatg ttaaaaattc actgtattca ttttcgtcta 2972101 aaggtgtttc actgatatcc ttaatcaata atttccactt caaatcatgc ataaccatat 2972161 attgaagaaa taaaggtatt ttctgttcat gattttttat aatatcgatt aaattctttg 2972221 agaaagtgat aagtgaatgg ttaaaccaat tcttatttgc tttagcagtc tgcatggcag 2972281 atgatccatc ttctctaact ctataatggt attttgcctc tttaaccaga ccatactttt 2972341 tcttttgcga tatgattaaa ttaactagtt tggcatcttc acctatttta caattttcat 2972401 caaacctgat atttttcaag gcatcttttt ttataaatgt agaacaacaa tgagttaata 2972461 tatgatgcgg ttctttttct acatccaaaa ttcttgtaga agaaaactta ttatttagat 2972521 tatgttctcc agttcttcct tctgcaaaaa aaatagggat tgctacaata tcaatttcat 2972581 tcttatgttc gtcaaagaag tttaaaacat tttcgaatgt tccttctgaa actaaatcat 2972641 ccggatccaa aaattgaata tatctacctt cagcatactt taaaccataa tttcgagcac 2972701 tgctcactcc gccattctgt ttctttgcat agacaatgtt attgggatat ttctgagcat 2972761 attctttaca aatgatttca cttttatcgg ggctatcatc attcaccagt attaactgaa 2972821 tattctcaaa accaatagtt tggttaatga tactttctat agcttcagtg agatacaact 2972881 caacattata aatcggcatt ataacactga aatcatagtt aaaacttttt tcgttcataa 2972941 aagattactc ctaacataat gtttatatga ataagaattc gggtaaataa aattaagaaa 2973001 caagagagta ctaatttttg caaaacaatt ttaatttagt aaaatgtatg aaaagcattc 2973061 cttacctttt tttaaaaacc cttgtaagca aacttttaaa aatgttcaca tggttaagtt 2973121 ctaaagaatc atttggtgtt tttagtacaa agtcaaatgc aaaggcccaa atcggtattt 2973181 cgacaacaaa accagcatat ctaaaatctc ttaatttata tccccatact tcaattgttt 2973241 ttttcagttc ttttcgtttg cattttttta atcttttaaa atattttata tatattctgt 2973301 cattttcttt catctcataa tactggttaa taaagtgccc tgttaattca agtctaagcc 2973361 cttttatttt tgccgaagta acagtacatg aactatgcag tactctttct ttttttatat 2973421 tttcaagagc ttctgtattt tcttttaata agtgaaacat aaattcttta tagtacatcg 2973481 gcatatcttg ttcttttata aattgcgggt caataaattt taaaacttta ataaaatcat 2973541 caacaaaaac tctttgttct tgttgatcta aaacagactt ataaacatct ctatagttcg 2973601 gatataaaaa cagttttata tgatatacaa ttaaaaattg caaataaggc aaaactatat 2973661 catatttgtt gaatgaatcc atcaacaaag tcatgtaaca ttcattcaac aaatatgtgt 2973721 accttttttt gttaaaccat gaacgatcaa ctaaagaatc ctgttctttc cgttttctat 2973781 aaaaatactt tccttctgca actgctccgt atcttttttc tttcagtaat aactggttaa 2973841 aaaagatagc gtcttcccaa aactttatag attcatcaaa aaggacggta ctagttagtg 2973901 tatgtcttct gtaaaaagtg ccgccaatat aaaaatgaat agctttataa tcgttgagaa 2973961 tatttataac tcttgttcct ttttcaaatc tattatttaa tttatgtccc ccttcttttt 2974021 cacctgtgta ataaacaggt aataccgcaa tatttacatg ttcggaatca caaaaaaaat 2974081 cataaacact ttgcagcgca ttttgagaga atgcatcgtc agaatcaaga aaaccaataa 2974141 atttagatct ttcgcttaca tttgataatc cacaatttct tgcagcagaa ggtccagagt 2974201 tttcaatttt catgatttta atattattag gatatagatt tttaaaggat tcacaaattt 2974261 gaggactgct gtcaacacta ccatcatcta ttaatatcag ttctatattt tccttaaatc 2974321 caattgactg gttaaggaca ctctctattg aatatcttaa ataattttca gaattatata 2974381 ttggtataat tatagaaaac atgtttgtac ctctttattt agaagttaaa ggatcgtttc 2974441 aattactctt ttagaagcct tgcctcttct aaattacaaa atttattata aaaatcctca 2974501 tagttatgat ctatataagg attatgtaac aactctttta ccgtatctat aagttcttca 2974561 cttgtttgaa gcaagtttcc tggcgttttt tgctgaaaat taaagtaaaa acctctgata 2974621 cagtctctat aagccgggag atcatacaca aaaaatacaa ggttttttta aaaattcata 2974681 ttatcaaaaa agacagaaga ataatccata atcaataaat cactaattaa atataaatct 2974741 cgaatatctt tatttaaaga aacatcgttc acaaaatatt tatatttccc taattaaatt 2974801 gttctgaaac tggataatac cattcttaca agaataacca tagagtctcc aaggttccct 2974861 cttcatttcc tctaatcaaa ttaaagttaa atttatactg gccagctttc ttaaaattca 2974921 ttatcccgca aagttggtgc atataaaatt atttttcttt aattccttat ttgataatgt 2974981 agaattggta ggggattgta gctaaactgt ttccagaata gctttcaaat aaaattaatt 2975041 tattgtttct tggcagaagg acaaaaattt taaacaaaac tgaataaact ctaactagta 2975101 aacttctgca attggttata ataaaaattt catcagtgaa ctccttaaag agtgaagatt 2975161 aatatttacg caaacaagaa aaaaagaagc aactgaattt acttcaagcc tcttttagtt 2975221 agtgcttcta taaactagcc atatcttttc tgatttgggt agttgaaatg cctgctattc 2975281 ttgtaaggta aatggcctca tagtattcct ttgtagacaa tcgtacgatt aagtaatccc 2975341 aggttctttt gctctttcca gtagcttcat atgtccatag tgaaataaat caaacattcc 2975401 gtacgtatca ctttcttcat tagataacat caccttccaa ccttttccaa cttagaaaaa 2975461 acaaaaatcc ttaactgatt gtttatcatt tcgacatatt ttttacgttc cattaataat 2975521 aaacaataat agcatatgtt cctataaaag ttaaggctct ttaaaaatgt aaatcatcag 2975581 cactttttga caatatcgtt gcattgatgt gtatttttta cagatctgat atcttatcta 2975641 tactcattac aacaagtttt ctattccgga agagtcaatt ctttttgtcg cgttttcaag 2975701 tgtaatgatt ttctttctgc tgcgtcattt attttgtacg ccctcctcat attacttcat 2975761 cgtcaaaacg tgaaggaatt gtaatacgta gttcctaaaa attttcgtgg taaaatttag 2975821 tgaagtcttt atcaggctaa gggactttat ctaaactacg aattacatat ggagatatat 2975881 agatgaaaag gagggttgat atgatataaa cgaaaatcaa ttagataaag gaaaaactga 2975941 acacttctga aaaaagtgat aagtttcttt cactatatcc tccaaaaaga acctaaaggt 2976001 cttggacatg ctgtctggtt cgcgcctaac tttatcggcg atgagccgtt tgcgtttctg 2976061 cttggagacg atattgttca ggctgacaca ccagggttgc gccaattaac ggatgaatat 2976121 gaaagaacac tttcttctat tatcggtgtt cagcaagtgc ctgaagatga aacacactgt 2976181 tatggcatca tcgccccgct gacaagtgaa ggccgccgtt atcaggtgaa aaacttcatt 2976241 gaaaaaccgc ctaaagacac agcaccttct aatcttgcca tcttaggccg ttacgtattc 2976301 acgcctgaga ttttcatgta tttagaggag cagcaggttg gcgccggcgg agaaattcag 2976361 cttacagacg ccattcaaaa actgaatgaa attcaaagag tgtttgctta cgattttgaa 2976421 ggcaagcgtt atgatgttgg tgaaaagctc ggcttcatca caacaactct tgaatttgcg 2976481 atgcaggata aagagcttcg cgatcagctc gttccattta tggaaggttt actaaacaaa 2976541 gaagaaatct aaacaaaaag gctattggac attcatccaa tagccttttt ttatttcaac 2976601 atcaaagtca gtgtatgctc ttcattatca actgcaaaaa cctgatcatc tgtattcaca 2976661 agaaaacgct tcttgctgct gtcatacaat acatcgctat cacttaagga tagtgacgcc 2976721 gggttgatag gagaaatgtt atgaaaaata agctctgttg ctttatcatt ctccagtaca 2976781 taactgattt tttcataatc aaaattcagc gtttttctgc cgtcagcctt atttccttca 2976841 gtataaccat tcaatttcga ttgaatgctg gtgctgctgt ctcctaggaa tttcagaaag 2976901 tattcatagg aagatgctgc gttttgcgag acataagacg taaatgcagt ggcatgcaat 2976961 tcagcgtgtt tcatgttagt tgcaacagcg ctctgtttca cataataaga gtgcccgtca 2977021 aactttattt tcgctgcttg tttgcctttt gcagctaccg ttacttttgt accgaatggc 2977081 agtgtaacgt cagccttctg tttcaaaccc tgatccttat aagcagccgc tttttcattt 2977141 gctataaacc cttgcttatt gattgcagtt aagcgttcct ctgacttgcc ctttgcatcg 2977201 ccatgatggt tcttcacttc attttgcgga atagcgccaa acgaagcaat tgtacgaagc 2977261 ggggcattaa agaacatcgt tcccgccatg aagacagtca gaatagacaa aatagcaatt 2977321 tgaatggcat tggccagtga tttcggcttt ttcttctttt tgcggaaacg ggcaaacgct 2977381 tcaggatctt ctttcttcct ctcttctgtc tgctcttttt tatatgtctc tttttctttt 2977441 ttcgatagct tattaaacca gtcaataaac gctttgtact ctttcacaac cgtttttgtt 2977501 tcatcaaaca tacgaagctc gccatagtgc atccaagcaa cacggtcaca catcttttca 2977561 atctgaccga ttgagtggct gacaaagaaa atcgtttttc cttgcttttt aaactcattt 2977621 attctgtcta cacacttctg ataaaacgtt tggtccccca cagaaagagc ttcgtcaata 2977681 attaaaatgt caggatcaat atgcacggag atcgcgaaac cgagacgcga cttcatcccg 2977741 ctggaatagt ttttaaccgg ctgattaata aaatcgccaa tctcggcaaa ttcaacgatg 2977801 ctgtcataca tatcatcaat ttctttattg gttaacccca tcatcaaaca cttgagccgg 2977861 acattgtccc ggcccgttaa ttggttattc aaaccggcag caatcgcaat cagcgacggc 2977921 tggccgttca tttcaatttc accgctggtc ggcggaataa ttttagccag caggttagac 2977981 atggtcgatt ttcctgaccc gtttattcct acaaagccga ttgtctcccc ttcatacacg 2978041 tcaaaggaga cattccgcac agcaaaaaaa ccattatcct tagccggaaa aaacaatcct 2978101 ttaatcttgt ccgattgttt tttatacaaa tgatactgct ttgaaacatt tcgaaacgaa 2978161 acttttagtt tcatcgtaaa atctccttac gtattaaaga aagtcaacaa acttgtctct 2978221 gaatttcata tgcaggatag aacctactaa caataaaagg aatgtgaaca accaaaagta 2978281 cagcgtgtac ttcatgtcat ggaaaaacca tgctccatct aagaagctgt tccggaatcc 2978341 ttcaataata tagaatagtg gattcaactt cagaacaggc actaattcgg ggtggctttg 2978401 accgagtttc gcattaacat cccaaaaaat tggcaacaag aaaaacaaaa gtcttgttac 2978461 ggcctgcagc aaaaattgat aatctctaat cagcacactg atcgttgagt taaacaaact 2978521 aaacgaaaac ataaaagcaa tcatacagat gaagtaataa atatattgta accaatgcac 2978581 actcgggaac acaccattaa ctaggagtac aatgatataa atcaccatca tgatcatata 2978641 actaaataag ttagatgcaa ttgccacgga cggtagagaa ctaatcggga agttcatttt 2978701 agccaccata ttaatgcgct taaatacact atttgatcca tcaagtatag ttggactgat 2978761 gaaaaaccat gggattaatc ctgccagcat ccaaataata aaaggcactt cgcccgctcc 2978821 ggttgtcaca ggaccgccct ttctaatccc cataccaaat acgaaccagt aggccagcat 2978881 ttggataagc ggatttaaga actgccataa gacacctaaa taattcattt gatatttaga 2978941 cttggtttca taagccgcca atcttaaaat taaaggaaat gacgttattt gctctctgag 2979001 tatacgcaac aaatcattca ttttttatct tccttagact taattgtttt tgggaatctt 2979061 tctgtttaaa atttgaaagc accgctgatt attgtaacag atcctgcatt ttttttcact 2979121 tctcaacaag tatctaaaaa gctgccgaaa aatcgacagc tatacatttt ataaaataac 2979181 ctaaattatt cagctttaaa tacagtatta acaacctttt cagatgaacg tcctgactct 2979241 aaatagcaaa acttatcata gaaaggacca aaagaaaccg gaagcttata atcaggcgat 2979301 gagatctgct tgatagcctc aatcgtttct tcagtagttt ttaccaaagg accaggagct 2979361 tctttttcaa aatcaaagta gaaaccacgc aacttgtccc ggtaggtttc gatgtcaggg 2979421 acaaagaata gcattggccg ttttaaattt gcaaaatcaa agaatactga agaataatca 2979481 gtaatcagca aatcagaaac catatacaat tctcgaatat cctcataagc agaaaaatca 2979541 tatgcaaatc cttcaaaagg acctaaatca aaattctcag ctaccagata atgcattctt 2979601 aagattacaa tatattcatt tccaagttct tgtctaagtt gatgcaaatc taaatcgaga 2979661 tcgaacttat aacgcccttt tgcatagaac tgatcatctc tccatgtagg ggcatataaa 2979721 ataacctttt tatcacgagg aatatttaac ctactcttta tcaatgatat tgtttcctca 2979781 ttattatcat tatgaagaaa atcatttcta ggatatccag attcaatcat tgtcttgtta 2979841 aactgaaacg cccgtgtaaa gatctcagtt gaataaccat ttggggaaat caagtaatcc 2979901 caattagaag cttccttgat aaaattcctt ttatattttt tggtgtttgt accaggcata 2979961 tggacttctt ccatatccat tgcaagtctt tttaaaggtg tgccatgcca tgtttgtaaa 2980021 tatgttgtat gactaggttt cggaatccat aatggaagcc ggctgttaac aacccaatac 2980081 tcagctcttg ccatagcgaa gagccatttt aatgagaggc gattaatgta aggaattccc 2980141 ttttcatcaa aaggcgctga atattgttta tttacactcc aatacatttt atactcaggg 2980201 tggttttccc gcatatattc gtaaatcgct ctcggattac aactgtattg tttcccatta 2980261 aaactttcaa aaatgactgt tttcctttta actggcattc tgctagccat catgaataga 2980321 gatttgtatg ttttagtgat taacttgttt ctcatttttg tgatcttttt tatttttgat 2980381 actaatctct tcttctttcc tttaataaag tatttcatcc ttgttttcag gctatagtcg 2980441 tttactctga tacctagagt ctgctttttc tttttcttaa agacttcata acgaactggt 2980501 gcgttgtttg ttttaataat acttactaat ccttttaatt tgttttttcg atctcctaaa 2980561 acaagagcag tgctgttgaa ctgaatatcc gttccttcat cgtcattgca tatatactcc 2980621 ataaaaagac gataaacata acgtttttca tttgagaaag gaatttcttt caaaggcact 2980681 ttcacttcaa aatcatacag ttccggaaca aaaccatctg ctctcatgtt ttccaggcca 2980741 tgtgtttttc tttctagctt gattggaaat ttttcctcaa taggtgtttc tccacccttt 2980801 tttaaaataa ggttcaagtt ttttatccga tattgatttt cggaactcag gtaccccgca 2980861 taacctgtta tgcttatttc ttcagagcta atctcgattt gatcaaatct gatgattttg 2980921 gcctctcttt tcaccttaat agaaaagttg cctttatcag ttgtataagg taaaatcaaa 2980981 agttctgtgg tttgatcgac atgaaaggcg cgctcaattg aatttacttc agcagaaaga 2981041 cgcttcaaga gtggttcctg ctccgcatct tcatattttt ttcgaaattc gacataaaaa 2981101 tcatatgttt gtcccatttc aacaggcata ggcaaaacat gagcatttat ctcagtttta 2981161 tactctaatg agccagtgtt ttgaagcgga aattcagatt ccgttcctga acgtctctct 2981221 ttcagcttta aaaataactg gtaatcctct aaaaattggt gttctgaatc aattgagatt 2981281 aacaattcaa gacttcctaa attgtttttc aagcttttca aaatacattt aatcacagtg 2981341 ttttcaatca ttactttttt ctgctcctct gtataaaagc tctttccttt ttgcttcctt 2981401 ttattagtgt caactactaa ggacattaac tctcttttat ttccgtgacc ctccaagaga 2981461 aattgccttt aactgttgta tagggctcta ctctatagcc attattagta tctatactgt 2981521 ttcctgacaa ttttgtttct tcactcgaaa gtcttcgcat tgttttaata tggccatttg 2981581 cattgaaaac aatataaaaa tcaataactt gggttttatt agcagctatc ttttcaatat 2981641 ttacatcttt ttcgagatca attacaaaca gttgatcatt ttgtaagttt gttgaaataa 2981701 tttcagcctt attctttctg tccaagccca ctaaacgtat ttttttaata tcattatgat 2981761 caaaattctc aatgtcaatt tctattttag ttttatcaaa atcctcagta taggaactaa 2981821 tagaaggatc tttttttcca acctttttag agaacttctc tctttctatt cgcacctcaa 2981881 tcatctgatt aagagcaaaa gcccaatttt caatatagtt gggtcttgaa tatttttcag 2981941 ccattttaaa agcttgttct gaaaattttt gatgagtact ttcatctttc atcaaagaga 2982001 taatagcttg acccaatttc tctatattat actgttcaat gacatatcca tttgctccgt 2982061 cagtaactaa gctccttgct ccgtaatcat aatcgtatgt tacaactgga catccattgc 2982121 tcagtgcctc catatttgat agaccgaacc cttcaaaatg agaggttgaa atggttagcc 2982181 aagctttttg aaactctgag tcagggttat ccgtatagcc tttcaaaaag acattgttct 2982241 gcagtttggt atcttcaatt tcttttttta ttttttcgaa atcttcaccc gatccgaata 2982301 tatcaagttt tgcttcagga atttctttca cgactaaact aaatgctttt actgcatgta 2982361 tcagattttt catagatgca agtcttgaaa taatgacagc tttgtatttt tcactcggca 2982421 cattcaatac agcgggatca agaggcttat caattgtatg cggagtaaag aaaaacgtct 2982481 cttgttcccc tgaaatcaat ttaaaatctt ctagctgctc ctcagttata aaaaagacag 2982541 catccaaatt atacatctga ctaaatactt ctttatagcg acccttaatt tgatatttat 2982601 tgctgccgta atgcttgtta tgaataattg ctccataata ggaagaaggt gattttttca 2982661 ctttaaagac atgtttgtct tgcggtctgc tgtccactaa aaacaactta ggtttatcat 2982721 tttgtttttg cagatattct atccaatatt gacgcagttc cgattcatct tttactttta 2982781 tctcaccctc aagggagtac caaataatat gagataattg aacatctttt tcttcattgt 2982841 tccatacata gagtttgtct aaatatactt gattttggtc attaatatat tcctgcagat 2982901 acatcttgtt tagctgcaca tcataatgag taacgagaac taagtttccg ttcttcgtat 2982961 attcctctct ctttatgagc tggtttttat cattccaata gtcgacgtac cggatagttt 2983021 ctccatctcc gtagtaaact acagacattt cattgttctt cttaccaaac aatctcaaca 2983081 gagtttttgc aaatttcccc attccaactt gcttttttat ctggtcaagg cctatccttt 2983141 cttcgtatga tcttttccca tttgttctaa cacttaaaaa atcatcgaat agattaataa 2983201 cacttgtgaa ttttttatca atcttaccgt tgctgtacaa ttcatcaatt tttgaagaca 2983261 actctaaatc aaaacgaaac gttaagaaaa aggtgttttg gttacactct tctccaaata 2983321 attttgaacg caataataat gatttcgtca gaccgccata attacttggc agtccaccag 2983381 agataaaata ataatccatg tcaggaattt gttttatatt agattcactc accgcatgta 2983441 aagacaattt tttactccct ttcggcatct agaatatatg atcattgaaa tttatatcta 2983501 cccggatact ttagtcacaa aaatcaatgt aagcatcaaa aagtacttct tatttcaata 2983561 agaagtactt taattagata ttgaaccaat gatatcagga tcctaaatta taaaccagca 2983621 atttcctctt tgatctttgt tgtagagatg ccttctgttc ttgggaggta aacaacctca 2983681 cactgatctt tgagaaagtc aaatttacct tcccagtcat cccccataac aaaaacatca 2983741 atattatgat caataatatc ttgctttttt tgctcccaat tcttttcagg aattacttcg 2983801 tccacatatc gaatggtttc taaaattaat ttacggtgct catagctgtg ataagctttt 2983861 ttttgctttt gtaaattgaa ttcatccgtt gaaatagcaa caactaaata atcaccaagc 2983921 tgctttgcac gctcaagcaa tttaatgtga ccccaatgca gtaaatcaaa agttccatat 2983981 gtgataactt ttttcattta aagaaacgct ccttcctaat gttaaacact attaaaaaca 2984041 ctactgacgt tagcgattaa attctaaaaa cctgtttgta ttccttatat cgacatattt 2984101 ctcgtatgtc ttcactgatc attaattata gcataccgcc taaaaaaggt taagtactca 2984161 tgaggagaaa aacattccaa aatatgtaat tacactcaga ctccattggc accaaggtct 2984221 gttgttcatt cgttcattca attgtaaaat tggaaacata tttaaattta atgtaaagat 2984281 aatgttaatc ctttgttgaa gatttatgtt aaaatataag gtagcttgat tttgctttta 2984341 gaaactctcg gtttttaact atataaatag aatcttaaag gaaggaggag ccagacatgc 2984401 aaacagagac tattcacaat attccttatg ttaacagtaa cttaacatca tttatcgatt 2984461 acctagagaa acattatatt gatcaaaaga ttggtgctgt catttccaca gtcaaccctg 2984521 aaattgcatt tgcagctatt aaagatcggg actactttga tgtactatct tcttcaaact 2984581 tcattttgcc tgatgggatc ggtgtagtca tgatgtcacg tttgactaac aacaggcttc 2984641 agtcccgaat cgcaggttac gatgttttta aagaacttct gggcgttgct aacaaaaaga 2984701 aaaaacgcat atttctgtac ggtgcgaaga aagatgttat aaaaggtgtt gtatccaaaa 2984761 tttcttctga atacccaaac attaaaatcg caggttattc agacggttat gttcaagatc 2984821 gcaccctagt ggcaaaacaa attgcaagag caaatcctga catggtattc gtagctttag 2984881 ggtatcctca tcaagagaaa ttcattcata actacagaca cttgttccct aaagccgtat 2984941 ctataggtct aggaggaagc tttgatgtat ttagcggtaa tgtcaaacgg gccccttcct 2985001 ggatgatacg tttaaattta gaatggttct accggttaat cttgaatcca tggcgatgga 2985061 aaagaatgct tagcatccca aaatatgctt taacggtttt aaaagaagaa aaaaacaaaa 2985121 aaactttcta tccaaagcct gaaaaagatc atacaaaaca gatttaaaaa caaaactttc 2985181 aaataaatgg atgataaaaa tgaaaataag atcactactg gcgaattgct atttgtattt 2985241 tttatcagca atcgcctttt ttctgcaatg ggtgaaacct gaaagcaaag tgaccctcct 2985301 gatctcattc gaagcaaacg caaaagcgat tcttgaggaa tatgaacaag gacaatactc 2985361 ttataaactt aacatcctgt atacccagca ggcctctgct attgccgaga gcttcccgaa 2985421 tgtagatgca tatttattac aagaaaaaaa ccctatccat ctcattaaag ctgtatacct 2985481 aatgtttaac agtaaagtga tcataacaga taattacttt ctattaacaa gtgtgttaaa 2985541 taagcggaag caaacgaaat gtatccaagt atggcacgca aatggctcac tcaaaaaatt 2985601 tggtttggaa gacattacaa acatgcaacg gacgaaaact gatattaaaa ggttccaaaa 2985661 agtatacagt tcgtatgatt atttaactgt tggctcagaa gagatggcaa atatcttcaa 2985721 gaaatcattt ggaataaagg ataaccaatt attaaaaata ggtgtacctt taacagaccc 2985781 ttattaccga gaaaacaaga aaaaaatttc agatactcta aacatacaaa gaaaaaaaat 2985841 aatcctctat gcaccgacgt ttagagatta taatatgcaa tcaattcaat tgccttttac 2985901 agaagaacaa ttaattcatc agttaaaaga agaatatgtt ttatttgtta agctgcatcc 2985961 cgccattcag aacaatattg atattaaata ttccagtgat tatattaaag atgtttctaa 2986021 ctatgccttg tttgatctac tcatggctgc agacatatta atcactgact attcttctgt 2986081 tccctttgaa ttttcgattt taaataaacc cattcttttt tatacttacg atttaaaact 2986141 ttatcaacag aagcggggat tggttgataa ttatctttcc ataatacctg gaagagcctg 2986201 ctatgacagt gaatcattaa taaatgaaat tcaaacccca tttaattatt ccaaaataaa 2986261 agttttttcc gatagatgga ataagtattc tgatgggaat tcaagccaaa atttattgaa 2986321 tttcatcgaa aatttaataa gctaaatgat gacacttgtt caaaacagaa caagtgttct 2986381 tttttctatt gaataccgaa cgtatgtttg ctttaatgta attagttgct tatggcagca 2986441 aataataata gaggtggtaa atttatgaga aaaaaagaac tgtttgattt caccaacatc 2986501 acgccaaaat tatttactga actacgtgta gcagacaaaa ccgtacttca atcattcaat 2986561 ttcgatgaga aaaaccacca aatttataca acccaagtcg caagtggatt aggaaaagac 2986621 aacacccaaa gctatcgcat aactcgtcta tctcttgaag gtttacaatt agacagcatg 2986681 ctgttgaaac atggaggtca tggtacaaat attggaattg aaaaccgtaa tggcaccatt 2986741 tatatttggt ctctatacga taaaccaaac gaaacagata aaagtgaatt agtttgtttc 2986801 ccatataaag caggcgcgac tttagatgaa aattctaaag aacttcagcg attctcgaat 2986861 atgcctttcg atcatagggt tacacctgct cttgatatga agaatagaca gttggcaatt 2986921 agacaatacg atacaaaaaa taataataat aaacagtggg tgacaatctt taacctggac 2986981 gatgcaatag caaataaaaa caatcctctt tatactatta acattcctga cgaacttcat 2987041 tatttacaag gtttcttttt agatgacggt tatttatatt ggtatacagg agatacaaac 2987101 agcaaaagct atccgaatct cataactgta tttgattccg ataataaaat agtgctgcaa 2987161 aaagaaatta ctgttggcaa agacttgtcc accagatatg agaataactt ccgtgaaccg 2987221 gaagggatct gtatgtacac caatcctgaa actggggcaa aatcattaat ggtgggaatt 2987281 acaagtggaa aagaaggaaa tcgtataagc agaatttatg cataccattc ttatgaaaac 2987341 ttcatgaatc atgtacctat gcttcgatcc cctttattaa aaaccgtggg gcaccaagat 2987401 acacctccag aaagatttca accatttatt caaaccttca ttttagagta taatgctcaa 2987461 aacaaaaaat ggatggttcc gacttcaggt tatttaccat cttacacatc aaatttagtc 2987521 cgaaatatta ctatcaatgc agatggaaac ttgcaagtca cattaaatga acgctatatt 2987581 agtttactgc atcaatcgat agaaggagat ttccgcttaa aacaaaagga tatccgaatg 2987641 ggatcctggt attttgccgg cggagaaaaa tcaaatgtgc ttgaaatagg ttttatgaaa 2987701 gggagtacaa aaatcagacc cgatgatgca gccatctcaa atgcttcaag aatgagtatt 2987761 tttatgattg ttgcggacaa gattgaggtg tgataatcaa ataggctgta gctatttaat 2987821 agctacagcc tatttgcaac tttctaagtt ttttatcgat attccggaac atcggcctac 2987881 tttatagacc agcttctttc ggggcaatat gcataaagaa aagactccag agattggagt 2987941 ctttttcttt tattgcaccc gtatacttcc tgcgtattta tccttccaat atgtgctcgt 2988001 gttcatattg gtaatggtca cgccgtttga taatgtgaca tgaacaactt gtccgtttcc 2988061 gatatagatg gagggattta agcttgttga ttgaaagaac acaatgtctc ccggcttcag 2988121 gtccgccttc tcaatcttag ttccggcatt gtactggctt gttgcgtatc gaggcaggga 2988181 aataccggct gctttctggt atacatattg gacaaatcca gctgtatcaa atcccgtctc 2988241 aggtgttact ccgccctgtt tgtaaggcac ttctccgaca taaagcgtcg cttcggaaac 2988301 aatcggattt tctttcggga ttgtcaggtt gtcaaatcgg cgaatacccg tcatcttcga 2988361 tttccagtaa tcctctgaca aataggaaat ggttactttt tctgaccggc ttgcctgaat 2988421 gaacctgcct gcgcccgcat aaatgcctgc atgtgaaatt cccgttttat acgtattgct 2988481 gaaatagacg acatcaccag gctttatgtt ctgaggggct accttctcgc ccactgccca 2988541 ctgctgttcg gctgatcgcg gtagataaat gccgagtgcc tgttgaaaca catattgcac 2988601 aagccccgag caatcaaagc cctctgacgg cgtgcttccg ccaaacacat atgggacacc 2988661 gatatatttt tcggcctcct gaacgacagg aacatcagcc gttgccggat cggcagcgat 2988721 tcgtctcgcc ccgatataag ttccgctcca atagctgctt tttttgtaat tggtgatgat 2988781 aacccctttt gactgtgtac tgtgaaccat ttggccgtct ccgatataaa gggcgtcatg 2988841 tgtcggaaca gtgccggtgc ttccctcttt cttgaaaaac aaaatatcac ccggcttcag 2988901 gttttccggt tttacagctg ttccgatttt atactggtcg tttacagatc tcggcagatg 2988961 aatatcagcc ttactgaaca catattgtat caatcctgat ggatcgaaac cctctttcgg 2989021 cgtttccccg ccatatttat actgatatcc aagcaggttt tttgcttcgc tgacaatcaa 2989081 ttctgatgat gtatcagctt ccgcaatctc cgcttttgtc ataattggaa ccaaaaaaca 2989141 aatgataacc gccacaagca aaaacttctt ccagtttgcc agtgtgttca cttttattat 2989201 ctcctcctct ttttgcagtt ttaacatcgg tatttttttg aatatgttaa gagacttttt 2989261 aatattttta cagaatgaat atgctgggca aataaaaaga gagtgtctca tcagacactc 2989321 tcttttttga attatttatt ggcgtttacc ggttcttcct gctgctggat tttattcatt 2989381 tccatatcaa tcttctgttt ttcctgatct gtcagctgat cattgaattt aaaagctgac 2989441 ataaacatga acacgatggc tacggcaaca aacggccaga tggctttgac aaatttcatc 2989501 tttatcactc cgattattta gattttagtt tgtcactatg atcaatatca aacgtcagtt 2989561 ttccgtcttc tactttccaa gcgaaattag agtctttcgt cagttcgcga ataatggttt 2989621 tctgtttaag gctgtctttt ttcacaggcg caggtgtcgc ttcatggata tcgatcggtg 2989681 tcacttcaaa gcgtcctgtt ccatttttct tcaggtgata ctgaaccagt gcactgtctc 2989741 ttgttctcgt ccagccttgg tcaaagacaa agttgccgag gctgtagaaa atgacggttc 2989801 cgttatatac ttcaatcggt tctaagacgt gcgggtgatg gccgacgatg atgtcagctc 2989861 ccgcatcaga catggctctt gcaagctggc gctggcggtc atttggatca ttgtcatact 2989921 cttgtcccca gtgtgactgc acaacaacaa tgtccgcatg ttttttcgct tctgaaatca 2989981 tagggatgaa gatttcagga tctgcgggca gcacgcccgg cgtattcttt ttagccgcga 2990041 aacctttccc ggacacatcg gtaaagccaa gcgtcgcaat cgttaccccg ttgactttct 2990101 ggtacgaaat tttctttttc gcatcactta agctgtatcc cgctccaacg atatcaagat 2990161 tttgcttcgc aaattctcca agcgtatctt tcatgccctg aacgccgtaa tccattgcgt 2990221 ggttgttggc gctgttgaga accgtgaaat tcatatcctt caagactttc actgattcct 2990281 tattcgtctg cagatgaatc tctttatctg cttgtttata attcttttga taggttaccg 2990341 ggttttcaaa gtttcctgct acataatccg aggctctaaa gatcggttca acatattgaa 2990401 aaatactgtc tgcccctttt tgctccgtta ctttttcaac atagcgtccc atcataatat 2990461 cgcctacaaa tgaggctgag agtacgtcgt cagaatacgt tttgaccttc ggcgtttccg 2990521 cttttcccgc ccacatgaaa gcgaacataa ggacaaaaac gatcggaatg gcaataaata 2990581 cgtgcttatt ggttttcttt ttttgctgtt ttgtcagctt tagcagcttt tcatgaaagc 2990641 tcagttcttt tttcatcgtt tgacacacct tacattaaat taagtagtaa acaaacatga 2990701 tagcaaaggt cgctccgctc aatagcagcg tgcttccgaa cgtaatggtt aaaccttgtt 2990761 tctgaatggt attggcaatt aaacctggca cgatgatgcc gattcctcga aattctgcga 2990821 tttcaaatgg tacaatcggg tatagaaaat caaacgcgat ttttaggacg atccctgtta 2990881 tcagcatggc agcgaatttt ctgcgtccgt acaaaatcat aaatttggat aaaccgtatt 2990941 tcacaatgac atacgtgagc aagctcacta gcaaaacaag taaaataaag accggctgat 2991001 taaacacaag tcctaaatat cccggtacaa caagtcctgc cggcacgatc cctgtttttt 2991061 ccgcaaaaat taaactgagt agtacaccta aaattagtgc gatgtataaa tctgatccga 2991121 acatgtctgc atttccccct agcttacgag ctgctttacc ttgtattcgt ggattttttc 2991181 aattaaaggc tctgcggcac catgaatatt gccgacgcca tatatgacac ggttgtgcat 2991241 tcttttcttt aacaattcca taatttcatc tgttgactta tactctagat catgcagttt 2991301 gtctgcagga attttgcctt cttcgtaggc ttttacgatc ggttctgttg tttcaccgat 2991361 taagatcagt tcacttgctt caatataagg caatacgtca tttgcgaatt gctgtgtccg 2991421 atcgacacgg tctgcgcggc agttcatgat gatgatcgga tcatcggtcg ggtaaccgat 2991481 ttcttttaca cgtttccata tattcaaagt agaagaagcg tcgtttgcgg caaacccatt 2991541 aacaaagtgc ccaggctcgc tcggactgat cagcggaaga attctcattg ctcccggatc 2991601 tggcggcgca ttcagcattc ccttaaatgc tgtttcttcg tcaatgccga gtgcttgagc 2991661 cacacccagc gccagagaag cgttatcagg gaataccatg tattcaaatt tacgtaaata 2991721 ctcatctgta atttttgagt tatcagcaat gatgactttt gtgtttcgtt cttttgcttt 2991781 ttgtttaaag aactcggtat attcactatc tgtaatgaca agatggccat tataaggaat 2991841 tgtagcagta aacgcttctg caatttcatc aagcgtcggc cccatgacat ccatatggtc 2991901 ttccaaaaca ttcacaatga cgccgatatt ggcctgcaga agttcttcct gaaagatgat 2991961 ttgataatct gggttaacag ccatgcattc actgacaatc gcgttagccc ctctttctac 2992021 tgtttctctc atgacttctt tttgctctcc gatattcggc ccctgaggtt tccgtttaat 2992081 cggcttttcc tccggtgtgt cccagtaaat cattcttgca tctgttcctg ttgtttttcc 2992141 aacagtcttg taaccggctt ctattaatat tccggttgtc agccttgtca cagtcgattt 2992201 tccgcggatg ccgttaatat tcacccgaac agggagggca tcaatgtttt tctgatgtcg 2992261 tcgtttttct aatattccga tgaccagtat gacagcacag gctataatga gtaaccacat 2992321 tgcttttcga catctccttc tatattgttg taaattcatt catcagtata tagaatcact 2992381 atgaattctc aatcggcatt atgtaacata atcttcccta atcgactaag ccaaacttct 2992441 cttttgaaag agattttata cctacaaact gttttctatt tttggaaaac agcaggactt 2992501 ataccttatc actttttaaa aaaatcaaag agaatgcgct ttcatttttc tcctgatatc 2992561 cttctggacg tatagtcaca ccctgctgtt tgtatttaat atgcatttca aatcaatctt 2992621 tttttcagcc tttgttatca agcatttcct gctatcatgc gtgtttccgg ttcttatgaa 2992681 cacaaaataa ttttatcctg tttcttaagg acaaggtcat aatgtcatcc tttctgcatg 2992741 gaataagcaa tatgaggccc attccaaaat gactaaggag gttcgagatg aaaacgctaa 2992801 acatacgagt ccgaattctc taacataatt aaacattttc tgggatgata gtcttttctg 2992861 tttctcccca tttacaggtc taaacgcatg actttgaaac aattttaata aaacttaata 2992921 tttgttcaag aaatcttcat ccatatttgt gaagactttg tcaaaaaaag agtgaaaacc 2992981 ttaaattttt caattatata tacaatttac aattagattt cttttgatat ttttattgct 2993041 aacttcggat tgttcatgat aatctatcta tgtaaacggt tacataaaca aggaggagct 2993101 gttttggcta caattaaaga tgtcgccgga gcggcgggcg tttcagttgc gacggtttcc 2993161 cgcaacctga atgataacgg ctatgtacac gaagaaacgc gaacgcgtgt catagcggcg 2993221 atggcgaagc tgaactatta cccgaatgaa gtcgccagat ctctatataa aagagaatcc 2993281 cgactgatcg gacttttgct cccggatatc acaaaccctt tcttccccca gcttgcccgc 2993341 ggtgcggagg atgaattgaa ccgggaaggc tatcgcctta ttttcggcaa cagtgacgag 2993401 gaattgaaaa aagaacttga ataccttcaa acctttaagc aaaatcatgt cgcaggcatt 2993461 attgccgcaa cgaattaccc ggatctcgag gaatacagcg gcatgaatta tccagttgtt 2993521 tttctggaca gaacgcttga aggggctcct tctgtgtcca gtgacggcta tacaggagta 2993581 aagttagccg cccaggctat cattcacgga aaaagccagc gcattacgct cttgagagga 2993641 cccgctcacc tgccgaccgc tcaagaccga tttaacggcg ctttggaaat cttaaagcag 2993701 gctgaagttg attttcaggt cattgagaca gcttcatttt caattaaaga tgcacaatcg 2993761 atggcgaagg agctgtttgc ctcttatcca gcgacagatg gtgtgatcgc gagtaatgat 2993821 attcaagccg ctgccgtttt acatgaagca ttgcggcgcg gaaaaaacgt gccggaggac 2993881 attcaaatta tcggctatga tgacattccg caaagcggac ttctgttccc gccactttct 2993941 acaattaaac agcccgcata tgatatgggg aaagaagctg ccaaactgct tttgggtatc 2994001 attaaaaaac agccgctggc agaaacggca attcaaatgc ctgtcaccta tataggaaga 2994061 aagacgacaa gaaaggaaga ttaagatgcg taatatttgt gtgattggta gctgttctat 2994121 ggatttagtg gtcacctcgg acaaacgccc aaaagccggt gaaacggttc ttggcacgtc 2994181 atttcagact gtgccgggcg gcaaaggagc aaatcaggcc gttgccgcag ccagacttgg 2994241 ggcgcaagtg tttatggtcg gcaaagttgg agacgatcat tatggaacag ctattttgaa 2994301 taatctcaaa gctaacggcg ttcgcactga ttatatggaa ccggttacac atacggaaag 2994361 cggaaccgct catattgtgc ttgctgaagg cgacaacagc attgtcgttg tcaaaggcgc 2994421 gaacgatgac atcaccccag cgtatgcgtt aaacgcgctc gaacagattg aaaaggtcga 2994481 tatggtgctg attcagcagg aaatcccaga agaaacggtt gatgaggtgt gcaaatactg 2994541 ccattctcac gatatcccga tcatactaaa cccagcaccg gcccgcccgc tcaagcagga 2994601 aacaattgat cacgctacct atctgacgcc gaatgaacac gaggcttcga ttttattccc 2994661 tgagcttacc atttccgaag ctctggcgct ttatccggca aagctcttta ttacggaagg 2994721 aaaacaaggc gtccgctatt cggctggcag caaagaggtg ctcatcccgt ccttccctgt 2994781 agaacccgtt gatacaaccg gagccggtga tacgtttaac gcagcatttg ccgtggccct 2994841 ggctgaggga aaagacattg aagccgcatt gcggtttgcc aatcgtgccg cttccctttc 2994901 tgtctgctcc ttcggtgccc aaggcggaat gccgacaaga aatgaagtag aggagctgct 2994961 gtcatgaaaa aacacggtat actgaacagc catcttgcca agattttagc cgaccttggc 2995021 cacactgata aaattgtcat cgcggatgcc ggactgccgg ttcctgacgg cgttttgaaa 2995081 attgatcttt cactgaagcc gggccttccg gctttccaag atacagcggc agtactggct 2995141 gaggaaatgg cggtcgaaaa agtcattgct gcagctgaaa taaaagcatc caatcaggag 2995201 aatgcgaaat ttctagaaaa tcttttctct gaacaagaga ttgaatacct ttctcacgag 2995261 gagtttaagc tgctgacaaa agatgcaaag gcagtcataa gaacaggaga attcacacca 2995321 tatgccaact gcatcctgca ggcaggtgta cttttctaga aaggaagatg aaacatgcag 2995381 attgaaatga aagacattca taaaacattc ggaaaaaatc aggtgctgtc aggcgtttcc 2995441 tttcagctca tgcctggcga ggttcacgca ttaatgggag aaaacggcgc cggcaagtcc 2995501 acgcttatga acattttgac aggcctgcac aaagcagata aaggtcaaat cagcataaac 2995561 ggaaacgaaa cgtatttttc caatccgaaa gaagcggaac agcatggaat agcctttatc 2995621 catcaggaat tgaatatctg gccggaaatg accgttcttg agaatctatt tatcggtaaa 2995681 gagatatcct ccaagctggg cgttttacaa acaagaaaaa tgaaagcgct agcaaaagag 2995741 caatttgaca aactttccgt ctctctttct cttgatcaag aagccggcga atgttccgtc 2995801 ggacagcagc aaatgatcga aattgcaaaa gcgcttatga caaatgccga ggtaatcatt 2995861 atggatgaac cgaccgcagc gttgactgaa cgtgaaatca gcaagctctt tgaggtcatt 2995921 acagcgttaa aaaagaacgg cgtctccatt gtctatattt cgcatcgcat ggaagaaatt 2995981 tttgcgattt gcgacagaat taccatcatg cgtgacggaa aaacggtaga tacaacaaac 2996041 atctcagaaa ctgattttga tgaagtcgtc aaaaaaatgg tcggacggga gctgactgaa 2996101 cgatatccaa aacgcactcc ttctctcggt gacaaagtat tcgaggtgaa aaatgcttcc 2996161 gtaaaaggga gttttgagga cgtcagcttt tatgtgcgtt ccggtgagat cgtcggtgtt 2996221 tcaggattaa tgggagccgg ccggacagaa atgatgagag cgctgttcgg cgttgacagg 2996281 ctggacacgg gtgagatatg gatcgctggg aaaaaaacgg ctattaagaa cccgcaggaa 2996341 gccgtgaaaa aaggtctcgg ctttattaca gagaatcgca aggatgaagg gctcctgctc 2996401 gacacctcga tccgcgaaaa tattgccctg cccaatctgt ccagcttctc accaaagggt 2996461 ctcattgatc ataagcggga ggctgaattt gtcgatctgt taatcaagcg cctcactatc 2996521 aaaacagcat caccggaaac gcacgcacgc catttatcag gaggaaacca gcaaaaagtg 2996581 gtgatagcca agtggatcgg catcggaccg aaagtgctta tcttggatga gccaaccaga 2996641 ggtgtggatg ttggcgccaa acgagagatt tatacgctga tgaatgagct gaccgaacgc 2996701 ggtgtcgcta tcatcatggt gtcatcagag cttcctgaaa ttctgggaat gagcgatcgg 2996761 attatcgttg tccatgaagg cagaatcagc ggcgaaatcc atgcgcgaga agcaacacaa 2996821 gaacgaatta tgacacttgc cacgggaggg cggtaatatg aaaacggaac aactgcaaac 2996881 agaacaaaaa cggattcact tcgacggagt catgcaaaaa ctcggcccgt ttcttggttt 2996941 atttattctc gttatcattg tatctatttt aaatcccagc tttcttgaac cgctgaatat 2997001 tttaaacctg cttcgccagg tcgccattaa cggattaatc gcgttcggga tgacctttgt 2997061 tattttgaca ggcggcattg atctttctgt tggcgctatt cttgccctgt ccagtgcttt 2997121 agttgcgggg atgattgtgt ccggtgtcga tccggttctc gcgatcatcc ttggctgtat 2997181 cattggtgcc gtactaggca tgatcaacgg attattgatt actaaaggaa aaatggcgcc 2997241 ctttatcgcc acgcttgcga ccatgactgt gtttcgcgga ctgacgctag tgtatacaga 2997301 tggaaatccg attaccggac ttggcacaaa ctacggtttt cagatgttcg gacgcggtta 2997361 ctttttaggc attcctgtac cggcaattac gatggttctt gcctttgtca tcctttgggt 2997421 gcttcttcat aaaacaccat tcggacgccg aacgtacgct atcggcggca acgaaaaagc 2997481 cgcgctcatt tcaggcatca aagtgacgcg cgtgaaagtg atgatctatt ctttagccgg 2997541 gcttttatcc gctcttgcag gtgccatatt gacttcccgc ctgcattcgg cccagccgac 2997601 tgcgggagaa tcgtacgaac ttgatgctat cgcggcagtc gtcttaggag ggacaagtct 2997661 ttccggcggc cgaggacgca ttgtcggcac gttaatcggg gtgctgatca tcggcacact 2997721 taataacgga cttaatctgc ttggcgtctc atcattttat cagctggttg tcaaagggat 2997781 tgttatctta attgcggtat tgttagaccg caagaagtca gcttaggagg gttttacatg 2997841 aaaaaggctg tatccgtcat tttaacgtta tcattatttt tgttaaccgc ctgttcgctt 2997901 gagcctcccc aatgggcaaa gccatcaaac tcggggaaca aaaaggaatt caccattggc 2997961 ttgtccgtct caacgcttaa taatcctttt tttgtctcat taaaaaaggg tatcgaaaaa 2998021 gaagctaaaa aacggggaat gaaagtcatc attgttgatg cacaaaatga ttcatcgaaa 2998081 cagacgagtg acgtggaaga tttaattcag caaggtgttg atgcattatt aatcaacccg 2998141 actgattctt cggcgatctc aacggcagta gaatctgcaa acgcagtcgg tgtgcccgtc 2998201 gtaacaatcg atcgatctgc ggaacaagga aaagttgaaa ccctcgttgc ttccgataat 2998261 gtaaaaggcg gtgaaatggc cgcggcgttt attgccgaca aacttggaaa aggagcaaag 2998321 gtggcagagc ttgaaggcgt ccccggcgca tctgccacac gggaacgcgg ctcaggattc 2998381 cataacatcg cagaccaaaa gctccaagtt gtcacaaaac aatcagctga ctttgaccgc 2998441 acgaaaggcc tgactgtcat ggaaaacctg ctgcagggac atcctgatat ccaagctgtt 2998501 tttgctcaca acgatgaaat ggcgctcggt gctctcgagg caattaacag ctcggggaaa 2998561 gacatattgg tgatcggttt tgacggcaat aaagatgcgc tcgcttccat taaagacaga 2998621 aagctgtcag ccaccgtcgc tcagcagcct gaattaatcg gtaaattggc tacagaagca 2998681 gcagatgata ttttgcacgg gaaaaaagtg caaaaaacaa tatccgcgcc tctcaaacta 2998741 gaaacacaaa aataattgtc tgatgtttag gaacctgcga taacgtgaat agagatatag 2998801 aatgaattat ttctcttacg tgaggagagg aacggcatga acaaaccaac aaaactattt 2998861 tcaacattag cacttgcggc tggaatgact gcggcggctg ctggcggcgc tggcacgatc 2998921 catgctcaac agccagaaac aacggtaagc attgatgatt tatacagtta tccgattgat 2998981 tcttatttgg tatcagcaga ggctctaaat gtcagaacga agccttccgc atcaagccag 2999041 aaagccgata cgctgcactt aggagatagc ctaaagctga tttccttctc aaatgctgac 2999101 tgggcaaagg ttaagtataa aaatggaaaa acaggatttg tatccactca ttacattgtt 2999161 aaagcagcga caacggtaaa aaccaaaaca aaaacaaaag tgtatacatc cgctgacgga 2999221 aagagcatta agactcttcc agcagacaca agcgtttctt ttttaggctg gagtaaaacg 2999281 aataaaggcg gttttgattt tgattgggta ttcgttgatt acggcggtac gacaggttat 2999341 atgaaaacaa aggatttaca catgacaaaa taactgagag ggattccgca taaatgcgga 2999401 atccctttta ttatgaattg atttgtcaca ttcccaagat atttctcagg aaatattgtc 2999461 gtatgctgtg tcgaaacctt acatgatcat cgacattttt gttcacgcta aaaagcggag 2999521 gtgtaaatat ggatcaattt gaagcagcat atgaatcgta taaagcccgg caaacaactg 2999581 ccgatcaaga aaatgttcca tctggaaaag aagaaattat tgcggttaga agaaatgagg 2999641 aagacaatat tatcgcagtg aaaaccaata caggaagaga gctcgactac cctactgcgc 2999701 tgtcagaagc aaaatcagga aaactcgctc atgttgatgt cttccataaa tacgggcgtg 2999761 acattttgcg aagtgaaccg gacggcatca aggaaaataa cctgtctgag ctgccggatt 2999821 tttaaacaaa tacagccctg ccgtatgttg gacagggctg tattttaaac aaaaggctgc 2999881 tggatgtatt cggctaaccg ttttgcactg tgagaaatat cctctgcagc tgcataattc 2999941 acgccataga acacatatgg aggcagatac ttcatgccga tcagattact cgtggcctga 3000001 aatggtttca atagctcact gatcgagtaa tgatttgctc cgcccgcttg atatttttcc 3000061 gcttcgctcc ctgttgatac agccagcatc agctccttgc catgcaaggc atttccttct 3000121 gaaccaaaag cccagccata agtcagcaca agatcctgcc attttttcaa gagcggcgga 3000181 gagctgtacc aatatagcgg gaattgaaag acaatccgat cgtattcctc gcacagctgc 3000241 tgttccttcg caacatctat cgcttcatcc gggtattcct tataaagatc ccgtactgtg 3000301 atattgtcat gtttactcaa ttcctcagcc cacgccttat taacaactga ggtctccata 3000361 tgaggatgca ctgccaaaac caatattttc atcagaccac acctttactg ttttgatgtt 3000421 attttatcta aaatcaggaa aagagccaaa taaaaagaaa gccctgctaa aaggggcttt 3000481 ctttttttct tttattcagg gcttccttca gttgtttcga tatctttcgc aaaatcaggg 3000541 ttatccagat tcgcattaaa gaaatccgct gtgttcggaa gtctgagatt catgttcatt 3000601 ttttgagaaa tcgtaaccgt gcaatcctca agcacatagt caaaaacgtg tccgcctgaa 3000661 ttgcgtcctt cgtcaatgaa gtgcaggtga tagccagaaa cggcgattcc gtttgcataa 3000721 gctggtgtca agaaacctac aatcgttcct ctcacgttgt cgaagttgaa aatcggctgt 3000781 gttttgaccg cttcaaccat tggcacgtaa ggtttttctt gaagttctac tgttcttgtc 3000841 tgcacctttt taaacaatcc gtcaatgcga attgcataaa ataagtttct gcttggcagc 3000901 atgctgttga tctctttttc aaagtcttcg cgtgtcattt tcgcatcaat tttgtgcgtc 3000961 atgtccggtg taaagaacgt aaatgaacag aacggtgaac ggtctccatt ttggaccggt 3001021 gtcgcggttc cgtctgagcg aagacggtaa aattcgccgt caaacccaat cagctctccg 3001081 tcaagcttgt taaaggttcc gataccgaag tctccatatt tcggaatctc tgacagttca 3001141 aaatctccgt catatactcc gtctaataga gaagtcattg ttgatacttg ataaatctgg 3001201 ctcacaggct gatctttttg accacggctg agcacttgaa tgttgctttc tcgtttcata 3001261 tttcccttca ctccttttat ttagtgctgt tcataaaaca gtgtcgtgat gcgcagagtg 3001321 ctagagagct ttcgttttca tgagttcccc gaattctttc ggaagcttgt cacttgctaa 3001381 attaatgtta tcactgtagt caaccgggac atcgatgatg acaggacctt cagcgttcat 3001441 gccttgacgc agaacatctg ccagctggtc tggtgattct acgcgcaagc cagttgctcc 3001501 gaagctttcc gcatatttca cgatatcgat atttccgaaa tcgaccgcag atgtacggtt 3001561 atattttttc aattgctgga atgcaaccat gtcatatgtg ctgtcgttcc atacaatgtg 3001621 tacaattggt gcttttagtc gaactgctgt ctctaattcc attgctgaga ataagaaacc 3001681 gccgtcacca gagacagaaa ccactttttc tcccggtttc accaatgaag cgccgattgc 3001741 ccaaggaagc gcaacgccga gtgtttgcat accgttactg atcattaatg ttaacggctc 3001801 gtagctgcgg aaataacgtg acatccaaat ggcgtgcgaa ccgatatcgc aagttactgt 3001861 aacatgatca tcgactgcat tacgcaactc tttaacgatt tcaagagggt gcgctctgtc 3001921 tgatttccaa tctgcaggca cctgctcacc ttcatgcata tattgtttta aatcagaaag 3001981 gattttctgc tcacgctctg caaattccac tttcacagca tcgtgttcga tatgattgat 3002041 cgtggacgga atgtcaccga tcaattcaag atcaggctgg taagcatgat caatgtcagc 3002101 gataatctcg tctaaatgga taattgtccg gtctccattg atattccaga atttcggatc 3002161 atattcaatc gggtcatagc cgatcgtcag aacaacatct gcctgctcta gcagtaaatc 3002221 gccaggctgg ttgcggaaca aaccgatacg gccaaaatat tgatcctcta aatctctaga 3002281 aagggtaccg gcagcttgat atgtttcaac aaatggaagc tgaacctttt tcaaaagctt 3002341 gcgaaccgct ttaattgctt ccggtcttcc gcctttcatg ccgaccaaaa cgacaggaag 3002401 ttttgctgtt tggatttttg ctatggccgc actgattgca tcatctgctg caggaccgag 3002461 ttttggcgct gcaacagcac gcacgttttt cgtatttgtg acttcattca caacatcttg 3002521 cggaaagctc acaaaagcgg ccccagcctg ccctgctgac gctatcctaa atgcatttgt 3002581 aacagcttcc ggtatatttt ttacatcttg aacttctaca ctgtattttg taatcggctg 3002641 gaatagcgcc gcattatcca aagattgatg tgtccgtttt aaacgatctg cacggatcac 3002701 gtttccagca agcgcaacga cagggtctcc ttcagtgttc gctgtcagca ggcctgttgc 3002761 caagttagag gcacccggtc ctgatgtgac taacacgact cccggttttc cagttaaacg 3002821 gccgactgct tgggccatga atgctgcgtt ttgttcgtgc cgggcaacga taatttcagg 3002881 tcctttatct tgtaaagcgt caaataccgc atcaattttt gcacctggaa tgccaaatac 3002941 atgtgtgaca ccttgctcca ctaagcaatc aacaacaagc tccgcccctc tgtttttcac 3003001 aagggatttt tgttcttttg ttgcttttgt caacaccctc actccttatt atgcatttta 3003061 aacgtaaaat tttaaatatc ttgtgataag tttcactata cactctttgg aaattgacct 3003121 ccaatatcga ttcgccttat gattaatatg taatacgaat tattaaccta tggaaaggaa 3003181 tgcatattga atggagcttc gccatcttca atactttatc gcagtagccg aagagcttca 3003241 tttcggaaag gctgcccggc ggctgaacat gacgcagcct cctctcagcc agcagatcaa 3003301 acagctggag gaagaagtcg gagttacgct tctgaaaagg acaaaacgat ttgtcgagct 3003361 taccgcagca ggagaaatct ttttaaatca ttgccgcatg gcattgatgc aaatcggaca 3003421 aggaattgaa ctggcacagc ggacggcccg cggcgagcaa ggccttctcg taatcggttt 3003481 tgtcggatca gctacatatg aatttctgcc gccgattgtc cgggaatatc gtaaaaaatt 3003541 cccatctgtg aaaatagaac tgcgtgaaat atcctcgtct aggcagcagg aggagctact 3003601 aaagggcaac attgatattg gtatacttca tcctccctta cagcatacag ctttacatat 3003661 cgaaaccgcc caaagcagcc cttgtgtttt agctttgcct aagcaacacc cattgacttc 3003721 taaggaatca attacgattg aggatttaag agatgaacca attattactg ttgctaaaga 3003781 agcatggcct actctataca tggattttat tcagttctgt gaacaagcgg gcttcagacc 3003841 caacattgtc caggaagcca cagaatatca aatggtgatt ggtttagtca gtgccggaat 3003901 tggtatgaca tttgttcctt cctcggccaa aaaattattt aatttggatg ttacttatcg 3003961 aaaaatggac caaatacagc ttaatgcaga atgggttatc gcttaccgca aagacaatca 3004021 taatccgctt ataaagcatt ttattcatat ttcaaattgt cagcagacaa gaactaaaga 3004081 gagtgatgca ggtacatgaa caatacttgc aatctctttt ttcttttggg attcttatgg 3004141 aatttttatt aatttaatat aatcgcttag tacaacttta tatcagtata cgtatacata 3004201 cagtacaaat agttggcaag gacatcagta agcgcaggac attagtttga ttttaaaaat 3004261 gaaagataga gaggtgaagt aaattattga gttcaccggc atattcacat tgctcgcttt 3004321 tttcgtaaca atgattttta ttttctggag accaaaagga ctaaatgaag ctatccccgc 3004381 cacatttggc gctttaatgg ttttattgtg cggaagtgtg tcattggcag acttagggga 3004441 aatcggaaca aaagtcacgg gtgcatcggt tacaatcctt gccactatga ttatggccat 3004501 tgcactagaa agctttggtt tcttttattg ggtggctgca aaactgctcc aacaatccaa 3004561 gggttcaggc atcaagcttt tttggctaac caatttgctc tgctttctca tgaccatttt 3004621 ccttaataat gatgggagca ttttgatcac aactccaatc cttttgcttg tactaaaata 3004681 tttaggttta aaaaaacatc aaaaagcccc atatttatta agcggtgttt taatagccac 3004741 agcctctagc gcaccgattg gcgtaagtaa tattgttaat ttaatttctc tcaaaatcat 3004801 tggaatggat ctatatcttc acaccgccat gatgtttgtc cctagtatga tgggactcat 3004861 ttttatgact tgtctactgt ttatgttctt ttataaacgt cttcccaaaa gcctgccaga 3004921 tataccgggc cattttcagt ctctgcggca tagaaggtac catcctcttc attcgccatc 3004981 agctccttta ccagaacgaa atcaaacaaa aatcatgttg tttgtgcttg catttgtttt 3005041 tctcgtcaga atgagtctat ttgcagcatc atataccggt atttctgttc ctctagtcgc 3005101 tgtcatcgga tcttttatcc tgttgagctg gagatggatt tatttcaaaa cctccccaag 3005161 agacttgtta tataaatcgc cttggcacat ttttatattc gcttttacta tgtatgtctt 3005221 aatttatggt ctgcataata ttggattcac agagttactt gtgagttatt ttgaacctgt 3005281 ggtttctgga agcctcgccc atgcaacttt cgcatcaggt atctctactt cagttttttc 3005341 taatctcttt aacaaccatc cagcgttaat gatcagtact tttaccttaa ctgaaatgac 3005401 cctgaatcct tcaacaacaa aaatcatcta cttggcaaat attatcggca gtgatatcgg 3005461 ttcattatta ttacctatgg gaaccttagc aacgcttatt tggatgcata tattaaaaca 3005521 gcatgatgaa agtatttcat ggggcgaata tataaaaacg accattatca tcattccgct 3005581 gactgttctt tttacgttaa catgtttata tttttggatc agttggttat ttctttagca 3005641 cagtatgaaa cgaaaaactg ccttctgctt ttcaagaggg cagttttgta tacactaggg 3005701 aagatgcatt gtctttagat gatttaactt ccaaatgact ggctctccac ttgcgttaat 3005761 aagctcaatg atattattag agacaccctt taatagtccg actttttctg gcacctctcc 3005821 catatcaaat atgaccaatt caccaatatt ttttttgatc tgctcctcaa aattacgcac 3005881 aagaggaact ttggaaggca cgaccggcaa ttgtgagttg tcaagagtat acggtgtttg 3005941 ttcagttgaa taaggggtaa accattttaa atgatgcata gatataaaaa gtattttaaa 3006001 tacgggtgag aaaaatacaa tataatcgtt taaaacattt gtaacatatc catggatcga 3006061 tcgaccccca gttacataaa cttcaataaa ctggcctttg accttgttta atgtatttct 3006121 atatgaaaaa gcttgagttt ctgcctctat cattggatct tccggattga tcaaaaatgg 3006181 cttctcagta ctggtcacta ttttcgcctt gtttatttga tgaagatgca acaagggaat 3006241 ataaagataa ttgcagccat caaaaataac aaaaatatcc tgtccgatat ctatgagggt 3006301 gccgacaaac cttgtatctc ctgaaatgac aacctcaaca tctgtgttaa ggaattgatt 3006361 caaacctttc acgattctcc tcctttaact gaaaaagggc atcactttat ctgatgctcc 3006421 tccattatct attaaaattt acgtttccag tgatagtcta tcgttctgac aatcgtttca 3006481 tagctataat cttccttttg ttttcctgaa ctttttattg aacttgaata gcctggtgat 3006541 cttgatgatt gataatctga agatcttggt gatcgtttag atgattttga tgattgataa 3006601 tctgaagatt ttaatgatcg tttagatgat tttgaagaac tttttgaacg tgacgaacgg 3006661 ccagatttgg atgattgata atccgaagat tttagtgatc gtttagatga ttttgaagaa 3006721 ctttttgaac gtgacgaacg accagatttg gatgattgat catctgaaga ttttagtgat 3006781 cgtttagatg attttgatga gctatatgat tttgaagaaa tgaacgaatt gctgtcctta 3006841 tcattattgt cttcctggtt ttgttcattt ttttgatcct cttttttgta cgaccctttt 3006901 ggacctaagc tgatgctttt tatgtgaaaa ggatagatgc gaagcacctc ttgatttttc 3006961 actatagtat aatggccgtc ggcattatct acaaggatac cctcaatggc ttccggacct 3007021 ccacgattaa ttgaaaccca tttatgagtc agactcttaa aaacctcgct taaatcatca 3007081 gcttccaaaa ctccaactgg cgtctgctct tctattttca aatcaggctc gtgtttactt 3007141 atacttttga tgtgatggat attaaaatac actaccccat cctcatttgt gtttaacgca 3007201 gcgtaatcat ctcccagcca gaccaatctt ccttttttag attccggacc cccttggtta 3007261 aattgaactg attggtttat taaatgtccg attaagctat gaaaatcatc agcatcgagc 3007321 atttcctcag tctcaattgt tgtggtgcta ttattggtat cctcagtaat acttttcaca 3007381 tgctccaact gataataaat tatttttttt tcagcttgta aagctatata atctgatttt 3007441 acagctgtta attttccttt tttagattcc ggacctccac gatatacagt aacaatttta 3007501 tctttcattg agtgcaaaaa gttataatac gatatttcat tatttgaatg atatttcatt 3007561 ctcctcttgc tcattcaaat tcctcctagt cacttataca tagatgataa acatactgca 3007621 tatatacgtg tcacatttat ttgttgaact aattcaatag cctaattgtc gctttttccg 3007681 cgaataccca ttttcacgca ttcataaaat acttaaatga tctttgaggt attgtgaacg 3007741 gtttttaata tactcgcaga tcacatccgg ctcacggtca aaacgctcaa tatcattctt 3007801 tttatacggg tccatgagga caaacggcct aatccgttca tacatcgcca tgattttcgg 3007861 ttccatatat tctattgtaa aaagagattg gagcgttttt tctaacaggc gcttgtagga 3007921 cttgcgaaac tcggattcat ccaatatccg ggcggttagt gtattaaatc cttgaattct 3007981 tacataatcg gcagccatcc gctctccatg gatatccctg ccccaagtcg catcataatc 3008041 ccaaggaatc acctcaaata atccggtttc cccgcttctg tataatgcgt agttgtggac 3008101 aaacccgtca tagttcgagg tgaatacaat accagcaagc cagcgcaaat acttatcgac 3008161 atccacgtgt tttgtcactt ctgacttaaa ctgagcttta gggaccgtat taattttaaa 3008221 aatcatatct tgtaaataaa aatcatcttc ctcagtccct gttttctttt catatccaag 3008281 ctccagcgat gttttcgttt ccctttctaa atcgctcatc agagaaaagt tggcatcatc 3008341 atccaccgca taaaaaatcg cgccatcagc cagcttcctt ttcgccaaat aatattcatc 3008401 tacggattca agttcaagat aaaccccttc attcttccca ttcatcttta caaacgcaaa 3008461 ctctgccttt ggagacagtg tccctagctc cgagaaaaaa tccagagaca atttgtttct 3008521 catcaaggaa gggtctttat actccgcatt taagtgaatc tctcgcgcgc cgcggaatgt 3008581 tttcggctga taaaaggaaa tatggtatga cttctttttg aagtctctga tatgtgatcc 3008641 ccgataagcg atatcaatat ccagcctttt ttgatttacc ttcatcacag ctggcaccgg 3008701 atcatcgtcc catatatcct tttttaattc acgcaagtct tttggatgaa caaacagctg 3008761 ataaagcggt aaattggatt gattcttcat ccataatcct ccttacaaat tttaggcttt 3008821 tatttttata agatctcagc ggaacactta tacacttttt aaaaccgcgc gtactatgag 3008881 ggtagtaagg atcttcatcc ttaacatatt tttaaaagga ggatttcaaa ttgggccact 3008941 attcccattc tgacatcgaa gaagcggtga aatccgcaaa aaaagaaggt ttaaaggatt 3009001 atttatacca agagcctcat ggaaaaaaac gcagtcataa aaagtcgcac cgcactcaca 3009061 aaaaatctcg cagccataaa aaatcatact gctctcacaa aaaatctcgc agtcacaaaa 3009121 aatcattctg ttctcacaaa aaatctcgca gccacaaaaa atcatactgc tctcacaaga 3009181 aatctcgcag ccacaaaaaa tcgtaccgtt ctcacaaaaa atctcgcagc tataaaaaat 3009241 cttaccgttc ttacaaaaaa tctcgtagct ataaaaaatc ttgccgttct tacaaaaaat 3009301 ctcgcagcta caaaaagtct tactgttctc acaagaaaaa atctcgcagc tataagaagt 3009361 catgccgcac acacaaaaaa tcttatcgtt cccataagaa atactacaaa aaaccgcacc 3009421 accactgcga cgactacaaa agacacgatg attatgacag caaaaaagaa tactggaaag 3009481 acggcaattg ctgggtagtc aaaaagaaat acaaataatc taagttttca ttgtttcaat 3009541 aggctgccgg cggaggtacg gaagcctatt tttttatttg ccctgtatta gatatatgtc 3009601 atgacataac atatgcaacc cgcatcattt ggtttccttt aaaccatttc gttataatca 3009661 aggtatccta acgataaagg cggttgttgc tatgtacata tttcaagctg atcagcttag 3009721 tgccaaagac acatacaagc tattgtcagg taccgttatt ccccgcccca ttgcatttgt 3009781 gacaacactt tcttcaggag gagcggtaaa tgccgcgcct ttcagttttt ataacgtcgt 3009841 cagctcagat cctccgcttc tcagtatttc tgttaacagg acggaaggac gccaaaaaga 3009901 tacagcacga aacgcagtgg agaacggaga atttgtcgtt catgtcagtg atgaagccat 3009961 cattgaagat atcaatgaaa cagctgcaag cttaaggccg gatgaaagcg agcttacacg 3010021 cacctcgctt catcctgttg aaagcaaagc tgtttcagtt cccggcatta aggaagcccg 3010081 cgttcgcttt gagtgcaaat tagagcggca tattaccttt gacaatgatc aaggcatcac 3010141 tacagcagat ctgctcatcg gaagagttgt ctgcttccac ctagatgaaa aggtgtatga 3010201 tgcagaaaag ggatatattt taacggatga attaaagcct gcctcacgat tggcgggaaa 3010261 tcactatgcc aagctggggg aagaattcac actgattcgt cccagctgaa gagaaggact 3010321 atttaaatag aagaaactag tcaaaaagac cttatgatta caaaatatcg cctgtaaata 3010381 actgaaaaaa tatcaaaaaa aagaacaccc agagcaagct cggggtgttc ttttatgaaa 3010441 cgtttttcct ttttcttcgt ataaaggtag attaggagga attggaatga caaacttttg 3010501 gattttaatg ctgatcgcta ttaccatcag tctcgcctct caatttttta taaagaaaaa 3010561 atacggtatt gataaatccg gctggcgata taagcatgtc agcaatacac acaaatggat 3010621 cgaaatcact ttacttattt tgtttgtgtt ttcactctcc ttttttccag ttgaatattt 3010681 gcttctttta ttttttattg tgattgactc aatacgtatt tttatggagt ggcattatag 3010741 acctgaagat aaacagtata tgtaccacat tgtagaggtc tcccttatgt ttatgctttt 3010801 gatttatgtt tgtaccctat agttatttaa atccccacag ccgctccgtc tccccgagga 3010861 tcggctccgc cttggagaaa gccttcttca tcaactttga ttgcagccgc ttgtcccatc 3010921 agcggatcat agtcaccgac aacctccacg agatgcccgc tgtctttcag tttttggatt 3010981 gttttgtctg tgaatctgcc ctcgactctg agaccttcgt attcctctcc ccacgttctg 3011041 ccccataccc agcgcggttc gctgattgcc tgctgtggat gcattccgta gtccagcatt 3011101 cgggtaatga tggccgtctg ggtctgcggc tggccttcgc cgccttgtgt gccgtacaga 3011161 atttttggct ttccgccttt acagaccata gccggcatca acgtatggaa ggtgcgcttt 3011221 ctcggttcaa gcgtgttgac atgattttca tccagtgaga aaaacgatcc gcggttttgc 3011281 agtaatatgc ctgtatcacc ggcagtgact gccgagccaa attcaaagta caggctttga 3011341 atgaatgaca ctgcgttgcc atccgcatcg attacggccg catatgccgt atcacttccc 3011401 accggcctgc tttctgccgg tattgcgaga tagccgattt cttctgccaa ttgttttgca 3011461 taacgtttgt ccaaaagcct ttcaagcgga atgtctgcaa acgccggatc agtcaggacg 3011521 gcatcccgat ctagaaaact ctttttcaat gcctccacaa gcacgtgata atactcaaat 3011581 gaaccgtgtt cgatttgggt gaaatcatag ttttccaaaa tgttcagtgt taataaaccg 3011641 gtaaatccct gagaattcgg cggcgcctga tacacactgt atcctcgata atcacttgat 3011701 acaggcgctg cccactcacc ccgatgcgct ttaaaatcat cgattgtcat gtaactgccg 3011761 ttattctgta aatgtgagac aatccgctga gcgagatctc cttcataaaa tgcgcttctt 3011821 cctttttcag caatcaagtt cagactgtct gcaagctctt tttgcacaaa ccgctctccc 3011881 gggacaggtg ctttgcccct tctcgtgaag atgtcagccg tgtaaggcgt ggaagccagc 3011941 agttcaatat tcttttctgt gtgacgacac tgatcagctg atacaggaaa cccattttgg 3012001 gcataatcgc gtgcgggctc caatacatct gcaagagaca gacgcccgta ctccttcagg 3012061 accgcatccc agctatcaac cattcccggc acggtaatag cactgtcaat tccccgcagc 3012121 ggaatcgcgc tttttccctt atatacatct ctcgttacgt tttttcctga acggccgctg 3012181 ccattgtaga cttttactgc ctttgtttcc tggtgaaagg tcagccaaaa ggaatccccg 3012241 ccaagtccgg tcatatgcgg gtacacaacc gcaagacaag cactcaccgc aacagcggcg 3012301 tcaaacgcgt tgcctccctt atccagtatg cggtttccgg cttgagaagc gagataatgc 3012361 ggactgacga ccatttgctt tgtaccgatg acagatttgt tcatcacaag tccccttttt 3012421 taagaaattt tcttcagtat agggagcctg atttttcaca tctactgatc cggcagaaaa 3012481 actgacgaac tttcttcttt tcgcaaataa taagatattt tcgcattcat ttcgaaaaca 3012541 aatgaaaaat tattatttct atacgtaact tttatgataa aatgattgct aaaaggctac 3012601 gaaagcaggt ggagcaattg agtcatgaat atcaaatccc caaccttgta cttgatgaga 3012661 ctgataaaca aattctcacg attttgcatg aagaaggcag aatttcttat acggatcttg 3012721 gcaaaagagt cgatttgtca cgggtcgccg ttcaggcccg tatcaaccaa ttaattgaag 3012781 ccggtgttat tgaaaaattc accgctgtca tcaatcccgc taaaatcggc atccatgttt 3012841 ccgtgttttt caatgtcgag gtagaaccgc aatttttaga agaggtcgct cttaagcttg 3012901 aggaagagcc tgcggtcacc agcctttatc acatgacagg cccgagcaag ctgcatatgc 3012961 atgggatctt taccaacgat caagaaatgg aagaattctt aacaaaacgg ctgtatccat 3013021 tgcgaggcgt cgtcagtgtt gattgccaga tgctgatcaa acgatacaaa agccgtatgg 3013081 gaatgaagct gtaaaggaga gaaacaaatg aaaaaccatc cttatcggga tatgacggcc 3013141 gcaatggttc gcaccggcat attagggttc ggcggcggac cttccgtgat tccgctgatc 3013201 cgccatgaag cggtcaataa atataaatgg attgacgatg atgaattcgg agaaatatta 3013261 gcaatcgcta atgcgcttcc cggaccgatt gccaccaaaa tggctgctta tctgggcttt 3013321 aagctaaaag gcacattagg tgcaattgtg gcgatcctcg cccacattct gcctacatgt 3013381 cttgcgatgg tgggcttgtt tgcggctgta aatgtgttaa gccattcagc aattgttgca 3013441 ggtatgattg gtgccgtcac gccggtaatt gcggtcatgc tcggaatcat ggcgtacgag 3013501 tttggccaaa aagcgcttaa aggtttcggc tgggttaccg gcatcctgtt ttttatcatc 3013561 gcttttatcg gcctgcaaac tttacagatt aatcccggcc tggtcattat cattttctta 3013621 gcttacgggg cgtttcattt taaactgaaa gacaaaatca caaataaaca ttcaaaagat 3013681 aaaggaatgt cagcctcatg atatcgatct atttatttat ggcgtttttt atcgcaaacc 3013741 tactgggata tggcggcgga cctgcgtcta tcccgctaat gtttgaagaa gtcgtaaaca 3013801 gatacagctg gctctcaaac gatcaattct caaatatgct cgcacttgcg aacgcattgc 3013861 cgggcccgat cgccacgaaa atcgctgcgt atgtcggcta cagcgcaggc gggtggcccg 3013921 gcttcctaat tgccctgatc gcaaccgtcg taccgtcggc gctcgcattg atcgtcctgc 3013981 tgcgcatcat ccagcgcttc cgccaatcac ctgtcatcaa aggcatgacg ctgtccgtcc 3014041 agcctgtcat cgcggtcatg atgctcattc ttacctggca aatcggcgca gacggcatca 3014101 aagcgatcgg ctgggtccaa tcgatcgtga ttacgggaat ttcgctcctt gccatgacaa 3014161 aattcaaaat gcatccggca tttttgatta ttgcggcgtt tttatatggg ggccttgtga 3014221 tcccttattt atagaaaaaa gcacctggac aggtgctttt ttattttagc ccagaaatgc 3014281 cgtttgatat gacagctgtt tcttctcctg cgtcactctt gatcatgtgc ttgacttgca 3014341 gcgtggttcc tgccattctc acagattgct tcaactggga cgaattggtt tcaacttgta 3014401 tccaaacagg aggctggacc ttccaaaata aatagagtgc aagaatcagc aagccagcaa 3014461 tgaccgacag caaaaacttc atatcgcatc gcttcttttc agtaagcggc tcgcagcgga 3014521 cagcgcctga tgatcacgaa gaatatcgcc tggacgattg ccttctccca gcacatagcc 3014581 tttaaaggac attcccataa aatgaaaaat atgttcgaat tgctgaatca gcggcagccc 3014641 ttttattttt ggattgtctc cgcccactgc tattacatat gcctgtttca ctgacatttg 3014701 ctgtttaaaa tcaggaaatc tcggatctct caacgtctgt gaccagcgat caataaacag 3014761 ctttaatgtc cctgacatgc caaaccaata aattggggtg gcgaatataa gaatatggca 3014821 ctgcaatatc cgttcaatga tagaatcgta gtcatcttga acaggacgaa agccgccttg 3014881 ggcgtgacgc agatcttcaa ttggttgaat tggatatttc tgcaaataaa tgtgctccgc 3014941 atcgaatcct tgaacagcct tctccgcaag aacatccgta tttccgccag accgagttcc 3015001 gccgttaata accgcaattt tcatgatgca tctgctcctt tgtttacgaa tgattttctt 3015061 catcatataa tggattcatc aatcaataca gatgattatt tcgattaatc caatcgctaa 3015121 aaccgattta gaaaggaaga gaacaagtgg aattgaagca gctgatcacc tttattacgg 3015181 cggctgaaca tgtaaacttc accctaaccg ccaaaatgct taattatgca caatcaagcg 3015241 ttacctctca gatcaaatca cttgaagaag aaatcggaac gcctttattt gaacggctcg 3015301 gcaagcggct tatcttgaca gaagcaggaa aaacgttcaa atcttatgca cagaagatca 3015361 ttgcgttaac agaagaagcg aaaatggcca caaatcaagt aagagaaaca accggaacct 3015421 taaaaatcgg ggcgacggaa agccagtgca cataccgcct gccccctatc ataaaagaat 3015481 ttaaacaggc ttttccccaa gtaaagctca tattcaaacc atatatctcc aatgaacaag 3015541 cgaaagaaca gctcttacag ggccagcttg atatcacctt catcttggat gtaaaccgga 3015601 tggaagacgc actgcacgtt gaatctttga ttcaggatga gatcaaaatg gtggctgcta 3015661 atgaccatcc ttttcctgcg gatttaccag taacattgaa ggatcttcaa aacgaaactc 3015721 ttctgctgac agaggacggc tgctcgtacc gcacgctctt tgagaacaat ttgcatgact 3015781 ccggtatcta tcctaacaaa ttggaattcg tcagcataga agccatcaaa caatgcgtga 3015841 tggccggact tgggattgga atcttgcctg aaatgacagt aaaagatgat attgcagcag 3015901 gccggatgaa agaactcaat tggcagagcg attgccccgt tttcactcaa ttagcatggc 3015961 ataaggacaa gtggatgtct gcgccattaa aggcttttat cgatttgaca cggaaaacat 3016021 tcaaataaaa cctctccaca aggacgacaa ggtttttgag accagggcac acacatacaa 3016081 aaaaaacact tgatgactta gagccccaag tgttacacgt gatttttctg ataaaacgtt 3016141 cgcaaaacat gcgtctcaag gtcagccagg cggacaggga tcggcagcct gctttcttga 3016201 ttgatcaagc tcatcgtgat ctgatagctg ctgtctaaat caatataatt accgcaagac 3016261 aagaaaatag gcttcacgtc ccgccgcgtt cgcagcgccc gtccatatac ctcgccgtca 3016321 atgataatat cggtgtatgc gcctacttca atttcaggcg tcacgaaatc gcagcctttg 3016381 attttgagat aggttttcgc tatcccaatc gtcggcttgc ccagaaaaaa agccgcatgg 3016441 gtggcaacgc ccatatgatt gtaatgcaga tatccgttgc catcaaacaa gaagacatcc 3016501 ggctccgtct ccagcttttt cgccgcctcg atgatcaagg gcagctcgcg aaacgcaaga 3016561 aaaccggaaa catacggcac gctgattctc cccatgctgt gcactttttc aatgacttct 3016621 tttgtatcag cgtcaattac gataatacag cacactccgt atggttctcc atcctgctcc 3016681 caataggcca ggtcgacgcc tgcgcaggtg ttgatggagt ctggatggat cgtgggggat 3016741 aggttgatac gatttttaag gttaaattgc acttgtaaaa agtcttgttc ctttttcata 3016801 tcaaatttat gcacatcaaa taccttcata acgattgctc actctcgacc taaattaatg 3016861 tgagtctctc ttctcgattc tagtatttca aaatgaggac tatctgtatc tatctcgtac 3016921 ttatttaata gattgccttc ttcatcccaa ttcttttcag aaattagtat ggaatgctca 3016981 tactgttgct cacttttttt cctgccattt tcaaaccaaa ttatgcttat accgtgcaat 3017041 tgcccatatc ggtattcttt ttcacttttt ttattcccgt tttcataaaa ttcacatgtt 3017101 aaaccatggg ccagaccatt cttatattta gtaaaataga tgatttgacc atttggatat 3017161 aattcgtaag ccagccctgt aaacggctgg ccattttcgt cttcaggatt atctaaaatc 3017221 tcatcactta ccgaagagaa ccataaatcc tcaaagtcca ctcccttttc ttttatactc 3017281 ttcatatcat attcattttc catactttaa agcctccggt atataatttg tattttgagt 3017341 tatatattca caatgtggac atctaggcat tgggacacct tctggcatct ttttatttat 3017401 tttcctagca cttactacat ataccattaa atcttttaaa tccgcatcag gtctttgaag 3017461 taacgcttca tttagagcat taacttcggc atgagaaccc gcccctgacg tctttatata 3017521 accttcttta agttctgtag gcatatttac aattctatca tgaataagtg gatgtagtac 3017581 cttaggtggc ttcccatcta tattgtttat tccaaaataa taattgcctg tttttttgtc 3017641 caatacacca gctaccgcag ggcctctttg ttttttagtt agaccagaag atttaattct 3017701 actaagttcg tttagtactt ctgcccttag atttattcga tggtgaagat cttctttaga 3017761 caatacacca tgcttatttc ttaaatattg aagcctagtt tgtttttctt cagtagtctt 3017821 agcaatattg ctaataaggc tttcattact cactttattg acatatggag catttttttg 3017881 gtacaaccga tcaaagtagt gtgccaatcc tgctccacca ataatagtaa tagcttccag 3017941 cgccccttgc ttccgcttct cctcagacac tttgtttccg aacatatccc ggcctgtgac 3018001 agcttctgag aatccgtttg acgcaacaag gccgtatgcg cccatttctg tcattttgag 3018061 aatgtctaag gatttgcctg ttttgtaggc gtctaatgcg tgttcagcag cgatagctgc 3018121 ttttccggtt ttgtagatgg cttttccgcc tttgaaggcc cggcctgccc agccgacgac 3018181 tggtatgaat ccggcagcgg ccatagctcc tgctgtcaca cgctccgcgg tggagagttt 3018241 ttctccggta accggatcaa cgccttcggt tgctctttta taatcataat agccagtgac 3018301 ttctccagta aagttgcaaa ctccatccca tgttttttcg taccacggtt tgtttgcttc 3018361 ttcctcggct ttttcctgga gccgtcttgc ttctgcttgc tgggtttttg catcgatata 3018421 ggttgttcct tgattttcta cttcaatgac gcttttgtag acttcattgc tgtggaaggc 3018481 ttttttgtca tagtacatag gggatgcgct cttcccattg ctggtggcct gcatgagaac 3018541 agaatatttg gtgagcactg cgttgtccag agattctaaa ttttgatatt cagtggtcag 3018601 ggattcatca agcttatcga cagctgtgat tgtatcacgt ctgatttttt gggcatcgcc 3018661 catcttatct gcatagtcgt caagcgtgta catgtcgaga tcaataatat cgctgatgcc 3018721 tgacaaaata gaatcgattt cttctttatg agcggagaca atctctgagg ctttcaggtc 3018781 tccattgggc agctcatgat ccaaaaaaga agtttccaca tatgaatcat tcagttcttg 3018841 atctttaata tctcctgaaa tgccgtttaa aaacgcaatt tgagcagaga caagcgtcag 3018901 ccagctgtct acgatttctg cctgtccctg aaaaaaatct ttaatattgt ccgcgccatt 3018961 tcctttaaaa ttatcgccta aatcggcaac tccctgaaac gcttttttca gcgtattcag 3019021 ctgctcttca agcgtctcat attgcttttt tctgctcttc gcttcttcga ttaaagattt 3019081 tgattcaaat actttactca tcgcactgcc ctttctgttc tattttaccg ctatcgcctc 3019141 gtcctgctct ttgagtgaat ctacgttatc ctttgtatcc tcgatatttt tctgtaccgc 3019201 ttttttgtaa tctccgagca tggttttgat gttctcctca cgctcatggt attttttcgt 3019261 ataatcgagg ctgttttttc cgttggatcc tgcggcgccg attgatacgt cagcaagcgc 3019321 atctttgaca gaatctaatg ttttgatgac tgtgtcgtac ttcagcttaa tttctgacat 3019381 aaaaaaagat caccaccatt ttagtttact aattgtattt ccgacttctt ccgcgaactc 3019441 ttctcccttt ttaagaagat ctgctgcacc atttgctatg aacaattccg atgcatattt 3019501 agctttatcc cattcaagat caaaaatttt cccgttaatc gaagccatat actcgttata 3019561 tttatcattc acaatcttag atgcttccga tttcgcctct tctcttccct tgtcgaaatc 3019621 atcggctttt gttcccgtcc aatgcttgcc caattccggt ttcacaattt ctttgatttc 3019681 agtgattgcc tcttcttgca gtgtgtctat gtcctttttt gcttttttca gcttttcgat 3019741 cttgtcttcc acgtctgaaa tttttccgtt gagcgaactt ttgatatccg ctagcatact 3019801 ttcataaccc atctgaatca cctcttaata ctcaaaaagt cgtatggagg ggctgatgaa 3019861 gatagacttt tccatacttt atttccatat attatatttt aaaatagcca gaaggcggct 3019921 taaatagggt aaatggctta atttaggcat ataacgctct tgaaatgtag gtatttgatc 3019981 ttgtttttgt tcgttataca gctaataaaa gcgttttata aaatgaaatc acctaatgtc 3020041 atagttataa aggcacttga aagaggcaga tgttgttgat ctgcctcttt cggcgctgag 3020101 cttattgttc atgtttatgt tcttcatctg gtcggccatg tctgattttg tcatttggct 3020161 tctattattc cccccttctg accctttgga tcaaaagctt gtattagctg cagtcccagt 3020221 tgtacagaac gtttgaaaag tcttttttcc ttagatcttc aggtgtgatg aaaaaattgg 3020281 cgatgccgac gtctccccac attgaatcga tatcatcgtc tgaatcaatt tgtaacagca 3020341 tgatggtgtg ttctttatat gcgtattccc ggggatcatg ctgggtaaaa gaagcgtatc 3020401 cgccaatttt atggccaaat ccgttttcag ccagttcatt ataaatgtct tcttcatcct 3020461 cgccgaactg accaaagaac tccattgttt ccatgcccgt atactgctca aattgaaaat 3020521 ctgtaggcag cacccattcc gaagatttca caggctcgac tgccgcttct gataaaatcg 3020581 gaaaatcaca ttcgcctgtg ccaataaatg aaaaatcaga aacaagctcg tcatcgtttt 3020641 ctacgatatt ttcaaaatag atcactctga aattcttttg ttcacatcga tcgtcaaaat 3020701 tcaatccata gacgtcatca tgaacagaaa tgtagaactg caggatacct gaagaagggt 3020761 agccgtcaag ctggggaatg tgcgagaaat taatctgcgc cagaagtttc atcggctgtc 3020821 cattttcgtc agtcggatat gtttcatgct tggggaaata gggatcaccg gcaattttgc 3020881 tgtcatatcg tcctgttttc ccctttctca cattcagttt cacgtattct ttcgctgatt 3020941 tctccagcaa gtcgcggtac ggtctcattt tttcgggcag atgattcatc agattctctc 3021001 cttttccggc atctccaagg ttttattttc tggttttctt ctaatgtttt tcaaacgaat 3021061 gtttaaagaa gccctacttc tgcataattt tccaaacaat agttaaatag tagcaaatgt 3021121 attcagcacc ccgcaataga tgaaaaaaag actggtgcgc aaccagcctt tctttttcat 3021181 ctattgaatt gcacctgacg gaacaaccgc cttccgtccg acagaataat actccactcc 3021241 tgcagccaaa gcctcatcca atgtgtagca gtttctgccg tcaaatatga gcggcgtttc 3021301 catcaaatcc tgataagccg ctaacgggaa ttgtttaatg tcagcccagt cggttaaaat 3021361 catgacggcg tcagaccctt tgacagcttc ctcgatcgtc tctttatatt caacagcttg 3021421 cgggagaaca tgctttgcat ggctaactgc aatgggatcg taggctctga tacgggcgtc 3021481 gagcgcagcg agacggtctg caataacaat tgacggcgct tctctcatat cgtcggtatt 3021541 cggtttaaat gacaggccta aaagggcaat cgtttttccc gtcaccccac cgagcctgtt 3021601 cagcgcttta tcaaccagca tcgcctgctg attgttgttg actttgataa cggatttcag 3021661 cagttcaaaa tcatgctcga cattgccggc aatttgcacg agggcgtttg tgtcctttgg 3021721 aaaacaagag ccgccgtagc ctatgcccgc ttttaaaaac tggctcccga tccgcttatc 3021781 ctgtcccatc ccgtatgcga ctgcttcaat atcggcgccg accttttcac atatattcga 3021841 aatttcgttt ataaaactga tcttagtggc cagaaaagca tttgaggcat atttgatcat 3021901 ctcggcgctt ctgatatccg tttggtaaat cgggatttga aacggacgga agagctcctc 3021961 cagcgtattt gctgttttct catcggccgt cccgatcacg atcctgtcac catgaaaggt 3022021 atcatagatc gccgacccct cacgcaaaaa ttccggattg gatgcgaccg aaatactgac 3022081 aggctccgct agatgttcag taatcagtcc attaatcaaa tcgtttgtcc caacgggcac 3022141 tgtgcttttc gttaccacga ctgtatctcg tttgacatgc tttgcgatgc gtttggccgc 3022201 atctgtaatt tgctccagat tggcgtgccc gtcgcttttc tgcggtgtgc cgaccgctat 3022261 aaaaatgatg tctgcctgtg ccaagccttt ctcatagctc gtttcaaagt tcagccgtcc 3022321 atcagctgta ttttttctca tcagctcttc aagacctggt tcaaatatgg gggaaatgcc 3022381 ctttctcatt tcatcaatct tgtgagcgtc aatatcaatg caggttacat gatgtccaat 3022441 ctcagaaaga gaaacacctg tcacaagacc gacatagcct gttccgatga ctgttatatt 3022501 cattgtttcc ctccaacagt taaattgctg ctttgcagct tccgtaatat cgtatgagaa 3022561 catcctatca tgaatgcgaa tgatctcccg catagcctgt cgggtacagc ctgtacagat 3022621 ttctgaaatg tgattcaacc atacaataca ctattatatc gctctcaaaa agaaagtggt 3022681 gaaatgagaa tcggctgtta aaaaaaacca aacaattttc ttcttttgac cggctgcgga 3022741 ggctgtctga agatggtctg attccgcagg agaagctctg cattttccgt cagcatataa 3022801 ggaagttccg agccgaattc tttctctaga acataaagag cctcttgagt gtgaaaattt 3022861 ctcgttttca cattatgggc atctgaggct acgaaatgga tcaaattggc ttcaaccagc 3022921 cggagagaaa atgctttcag ctgcttgccg aagatccccg caagacttcc tgaagtaatc 3022981 tgagatgctg ctcctttttc cacaagatga tacagcaagg acgggttttc gcgaatttcc 3023041 ctgttgcgtt caggatgggc gataaccgga atatatcctt tcagctgcaa atcataaaaa 3023101 agctgctccg catatcgggg aacgtgatca aacggaaact caatcaagat gtattttgta 3023161 tcattcagcg aaagcagctg acgtttggca aggtcttgtt ccacctcgcc gtagattctg 3023221 atttcctgtc ccggaagcac atgtaaagga atgtcttctt tgattaaacg tttgtttaac 3023281 tgatctgctg cttctctgac tgcggctggc tcgtttttat acacaccgtt gttatgatga 3023341 ggtgtcgcaa tgatcgtccg gattccctga cgaacagctg ctcttgccat ttctatgctg 3023401 tcggccgaat cacctgcccc gtcatccatt gcgggaagaa tgtgacagtg aatatcgatc 3023461 atgtcctagc cccctttttt cgcaaaaata aataacgggc acgatgcacg ttatttattt 3023521 ttgcatgaaa ttgtccttgg ttccgtaata tccgtattca gagtgcttcg aaagcttttt 3023581 gccgttcata atcgccccaa ggagcttgct tttgcacgtt gcaagcgcct ctttcgcttt 3023641 tgcggcttgt tctttttctg ttttcccgct tgaaataacc agaacagaac cgtctgccac 3023701 gttgcctaaa atctgtgcat ctgctacggc aagaataggc ggcgtatcaa aaatgaccat 3023761 atcatatgcc gcacacgctt cgtatgcaag ctccttcatc cacttcgagg agagaagctc 3023821 ggccgggttt ggcgggatcg ggccgctcgt cagcacgtca agatgttttt cattcgatgc 3023881 ttgtacagcc tgctccatag agcttttctt taataaaaca gatgttaagc caaccgtatt 3023941 ttcaagaaaa aaagccgtat gtactgttgg ttttcgcaaa tcagcatcaa tcaggagcac 3024001 tttttttccc tgttgggcga atacgacagc caggttggcg gccgttgttg attttccttc 3024061 ccccggacaa gccgatgtaa tcatgactga tttcatttgc cggtccactg aagcaaattc 3024121 tatattcgtg cgaatcgtcc gatattgttc agagttcaag gatttcggct ctgtcattgc 3024181 aatgacattt ctctgcatcc gcgagcctct gttttttcta agcgccaaaa tgtccactcc 3024241 ccgttttttc agattggaaa ccctgtaagg tctttgctgt tttctgctca ttcgcaatgg 3024301 tggaaactgt ccctaaaaca ggtatgtcca gcaaggattc gagctgctct tccgatttga 3024361 tcgtattatc caaatgctca agcaggaagg ccagtccgat gcttcccgcc aatccggccg 3024421 caaacgcgat ggcaatgttt agtagcggct ttggcgatac aggggacggg tgttctgaaa 3024481 cctcggcttt tgacagaatg ctgacattgt caacattcat aatggatgtg attttgtctt 3024541 gaaaaacaga tgctatagta ttggcaatat gagccgctgt ttccgcgttt tcatccctga 3024601 ctgatatgtt gaccacttgg gagtcctgtt cgctggatac ggtaattttg tcattcagtt 3024661 cttgggatgt catcgacagg cccatttctt taatgacttc atctaagatg gcagggctct 3024721 taatgatgac attgtacgta ttgattaact gaagattggt ttggacatcg ttaaattgga 3024781 cttcttttcg ttcatttttc gattggttga ccagaatctg agttgaattt tcatagatgg 3024841 gtgtaagtgc gaagaaacta atgagtccgc cggcagcagt ggcagccgcg gttacaatca 3024901 taatcaaaag tatgcgtttt gttaacgttg ataatatctc ttttaagctt gtagattctc 3024961 ccatgatacc tccaaatctc ttataacatc cttttccatc tacgattata caacgttgaa 3025021 accgcatttc tccagctttt cacgtgacat aattcgacat ttttttacaa tgcgttatgt 3025081 tagtactttt tatgtaagcg ctatatttac tgtgttgaca gtgctgtctc attttctctt 3025141 attcgggcag tcacgttctc tcgcataaaa aaatcccgct aaaggcgtgc gggattttta 3025201 tgttgcatat ccatttttaa tatgagaaat caaattttca agcatttcct tcgtcgtcat 3025261 ctcagatgac tgctcaccaa tttcatgtgc atgcatcaaa attttcagaa attcttcttg 3025321 attcaatttc ttttcactca tctttttttt cctttcagct tccattaagt tgaaaacacg 3025381 attattatat gatgctggtt atcaatttgc aatctctaat acatcattcg acacatccta 3025441 ttttttatgt ccttttttag gaaaaacttt ttaaggccga tgtgttgcga tataatagag 3025501 aaattggatc tttttattac gtgactcggt taggagcgat aatcatgctt cagaatatga 3025561 tttccaaaga cgatgtgctg gcatctgctg aacagttaaa agaacttctt ccttacaatg 3025621 aggaaaatgt tcagctgatc aaaaaagccc ttattttata tcggcaggat tcagtctatc 3025681 gtttacaagc agtgagtccg acggaagtta cggcttacgt gcaggatgtt gtgcctgtgc 3025741 gggtcacatt gaacttgttt gtcatagtca aaagcggctg ttcatgtccg tccggaagaa 3025801 tctgccgcca tatgctggct gtgtttttat atgtatatgc aatgttcgag cgagtgggta 3025861 cttttacaga gtattggctg gagagggaaa agcttgagga aagcaaagag ctcgtccgcc 3025921 gccagtttca ggaaaaggtg ctgcctaatg aagaatcact ttcaagctgg cttgcttttt 3025981 ttgattcaga gttttctctc tggcaggcac gtacgccaga aggcagccaa aacatgcagg 3026041 gcctctatta cggctacctg tccgcattaa aaaaacatgc gccgaacaag ccggagctga 3026101 aaagcctgta tcagattcat tccgcgattg cggtttggct tcgcatgttc acattgattg 3026161 aagcgggcaa gctaaacccc gaacaagatt tttattccct caatccgtac gttgaacagc 3026221 tgatggatac aatctacagc tctattgata aattaaaaac gtacgcgctg tcttttgcgc 3026281 ttgatccgtt tttggataaa acaccggatg ttatccggca tttgctgttg aaagaagaaa 3026341 ttttccaata tgaacgcatc cgcgtcttcg gtgaaatttg gagtgcgctg ctgtcgcggc 3026401 caaaatgggt ggcacgcgaa caggagatat tgaaaaaaga agcaggacgg cgtttttctc 3026461 ccgaattgca attcgggcgc ctgcatttgg aattcctgca aaaaaatgat gacgttattt 3026521 ttgaggaagc ggatcaattc ccgccggaag cgctccctta tacattccaa tggctgagtg 3026581 aaatgactgc caagaaggac tggaaacggc ttaaaacatg gtaccagcaa attgaaccaa 3026641 ttgcgatggg ttatacgaag ctggataagc cgtttaaaga gattcgcgat gtgatcggcg 3026701 agctgttcct tctgttgaat gcctatgtgc agcaaaccaa tgatcaagcg ctgtttgagc 3026761 gctttgccgc gggctgtctg ccgtatacgt tcacagaata cagccatcat ttatatgaaa 3026821 aaaaacgcta tgccgagtgg attgaaattc atagccttgt cggcttttcc atcaatgaaa 3026881 tggataaaat gatgctcaag gaaattgcag cgagcgaccc tgaggcgctt ataccggctt 3026941 accatagaga agtggctttt ttcattgatc agaagaaccg tagctcgtac aaggaagccg 3027001 cccggtattt gaaaaaattg cgcaccctgt acaaaaaagc gaaaaagcag aaggtgtggg 3027061 agcggtatat tcagctgctg agctcgcatt acaagcgcct gcgtgcgctt caagaagaac 3027121 tgcagaaagg aaagttgatt gatggcgagt cttaaagaaa ttctcatcca cgtcgaacaa 3027181 atggaagatg ggtcatttac gctctcagcc tttgatgaga atgagcagcc tcttccctac 3027241 agccatatga aaaagcattt gttccaatgg catgaatcct cattttacgg aacctttcta 3027301 gaggatgtca gcttcatcgg gacgactgct gtccttctat ctccatggat gactgtagag 3027361 cttctcggca aaaactcgtt caactcattc agctccgtgc agcttacaga agaaacggag 3027421 ccgctgatcg aggcggcatc gaccatctat gaatttatcg cggacggcga ttttatgcct 3027481 gactatgacg catggacaaa cggtgttttt cgctggaagg accgcgataa tatactggaa 3027541 ggctttactg cggaatggtt ttccgctgcc gtacaggatt acatccagta cgacgatgac 3027601 ctgcgggaga aatgggaaca tatcaaggaa aaatcgcctg cggttacgac attccgtggc 3027661 cattttcttg atgaagagga ttttctggaa ggcattggct ggattgacga tcaatctcca 3027721 tttactgtcg gcttgcgctt aaatgaaccg gactttgacg gagacgaatg gaagatcgag 3027781 atgtttttac gcgataaaaa gagcggtgct gtagaattct ttgacggact gaagagcctc 3027841 aaaaaatcgt ggcaggcgta cagcgataaa atcgcgcgtg agcaggaccg ctttcacaga 3027901 acggttccgt ggctgtcgtt tgattccggg acaacgctga tctcggagga agaagcctgg 3027961 atcttcctgt cagaagcaag tgagacgctt gtcgatatgg gggtagaaat cctcctgccg 3028021 tcctggtggc agattgtcag agacagcaac atgatgctga aagcaaaggt gtcttcctcc 3028081 ccgcgcggcg agtcatttgt cggcatgaat gcactgcttg atttcaactg gcggtttgcg 3028141 acaaatggaa ttgaactgac tgaggctgaa tttaatgagc ttgtcgccag caacaggcgc 3028201 cttgttaata tccgcgggca atgggttaaa atcgatccgc agtttatcaa acagatgaaa 3028261 cgcctgatgg aaaaagcaga atcagaggga ctccacatgt ctgatattct ggcgcgggag 3028321 ctaatggatc agcaggatgg cggacttgag gattcggacc tgattgatac atctgctttt 3028381 gccggcattc agtttgatct gtctaaacag ctcaggtcac tgattcgaaa gctcactgcc 3028441 gcggaaaacc tgccggagca caaagtcagt ccttctttca aaggaacgct ccgcccttat 3028501 cagaaatacg gcatgaactg gctgctgttt ctgcgggaaa gcggttttgg cgcctgtctg 3028561 gctgacgata tggggcttgg gaaaacgatt caaatgatcg cctatttcct tcacgtgaag 3028621 gaaagcggcc gacaaaaaac gcctcatttg attattgcgc cgacatccgt acttggcaac 3028681 tggcagcggg agcttcaaac ctttgcccct gatctgtctg tcgcgctcca ttatgggccg 3028741 cgccggccaa agggtgatga tttcgccgcg cattatgaaa acgcagacgt ggtgctcact 3028801 tcatacggtc tgtcacatgc cgatactgaa gagctttctt ctgtgacatg gaacacgatc 3028861 tgccttgatg aagcgcaaaa tattaaaaac gcgcatacga agcaatcacg cgcaatcagg 3028921 aagctgaagg ggcttcacca tatcgcgctg agcggcacgc cgatggaaaa ccgactgact 3028981 gagctgtggt ctatttttga cttcatgaat aaaggctacc tcggcagttt gaccggcttc 3029041 cataaacgct atgtgctgcc gatcgaaaaa gaccgggacg aaaagagaat cggacagctt 3029101 cagcaattaa tccggccatt ccttctccgc cggacgaaac gggatgaaga ggtcgcgctt 3029161 aatcttcctg agaagctgga agaaaaagaa tttatccctc tgtcagccga gcaggcatcc 3029221 ctttatgagc agctcgtcaa agacactttt gaccatatga catccctgac cggcatgcag 3029281 cgaaaagcgc tgatcctcag catgcttgga cggctcaagc aaatatgcga tcatcccgcg 3029341 ctttatttaa aggaagagca aaccgagctg ctggccggca gatcagtcaa gctcgaaaaa 3029401 ttgctggaac tgatgacagc gatccgcgcc caaaacgaaa gctgcctgat tttcacgcaa 3029461 tacattcaga tggggaacat gatgaagcgg ctgcttgaaa aaacgttcgg ggaacctgtg 3029521 caatttttaa atgggagtct ctccaagcaa gagcgggata cactcgttga gaaatttcaa 3029581 aggaaagaat atccgacact gattctttca ctcaaagctg gaggcaccgg acttaatttg 3029641 accgccgcca atcacgtcat ccattatgac agatggtgga acccggcggt tgaaaatcaa 3029701 gcgactgacc gtgcataccg cataggccag gagcgctttg tccacgttca taaaatgatt 3029761 acgacaggaa caatcgaaga aaaaattgat gtcatgcttg aatccaagca aaccctgaac 3029821 gatcaaatta tccaaagtga aaactggatt accgagcttt ccacacagga gctcgaagaa 3029881 ttgtttacat taagcgctac agcgcaataa tcatgactaa aaaagctggc tctaaaagag 3029941 ccagcttttt tccgttcata gccgtcacgc cgaatttcca aaaaatccgt tacgccggtt 3030001 atcaacaggg tgcgcttttg tggcagcaca tatacttaca acaaatgttt catcatatgt 3030061 gcgacaccgt gttcgtcatt ggttaaggtg acagcatcgg ctatcgattt gatgtcttcc 3030121 cgggcattgc ccatcgctac accttttccc gcagcctcca gcatcgattt gtcatttaaa 3030181 ctgtcaccta cagcagcagt ttcctcgagc ggaatattca gctgttttgc aagcctcttc 3030241 agcgcctgcc ccttggaagc tttgcgggaa gaaagctcaa agttgtgctc agccgaactg 3030301 acaagcgtca aatcttcggc atgctcatat cttttccagc ctgcctcaag cttttctttg 3030361 aagaaagaaa agccgagaat attgtaaaaa tcgattggct catcggcttc aaacagctct 3030421 tgaaaggagt taatgtaagc aaagcccgat tggctgtatt gcacctcggc cgcctgctta 3030481 aggacagaaa gatccgcttc cggatttgcg cttctgaatc tgtcgagctc aacatcaaga 3030541 agttctctgc cgttttgcgg cgtataaatc gctgaacctg tgaatacctc ataataatag 3030601 ttttccgact caagccatga gagaatgtca tacgcccgtt tcttatcaat cgtttcgtga 3030661 tgataaagcc tgccctcggg atcgtgaatg acggcgccgt ttgcactgat gacccatgtt 3030721 ttgatcccca gcggttcaaa gattgacatg acgtcaaaat gagcgcgccc agttgacacc 3030781 accacttcaa tgccgtcccg ctgcgcctgc cgcagtgcgt tttcattttc caagcttacc 3030841 tgatgcttgc tgttgagtaa ggttccatct aagtcaatcg caattaattt cacgtttgtc 3030901 agtcctttcc ttcatcctgc tctgtcacga gaagctcaac gccgtttcgg tcaagcaagt 3030961 cacaaaatgc ctgattcggc agcctgtctg taatcaagag gtcgatttca ttcagctccg 3031021 catactgata aaaactggtg ctgcccagct tagaatggtc tgcaagcgca attacctgct 3031081 ttgcctgctg tatcattttc cgcttcacca tgccatcctc ttcatgcgca attgtaatgc 3031141 catgttcgga aatgccgacc acaccaatca gcgctttatc aacatggtag cttgagagct 3031201 tttcaatcac agaggacccg tacagaaagc ggtgctcctt ttccagcttg cctcccagca 3031261 gataaatttc aattccctct ttatcggaca gcacatccgc aagattaatc gaattggtga 3031321 ttacggtaca atcaaccgca ttcaaatgct ttgcacatgc ctgaacagtt gtagaggcgt 3031381 ctaaaatcac ccggtctcca tcatgaataa gcgatgctgc aagcctgccg atcttatttt 3031441 tttcctcaga cactgttttc aggcggccgg aatagctttg aattttctga tgcacagtcg 3031501 gtaaaatggc gccgcctctt gtgcggatga tggcattctg ttcctcaagt ttcacaagat 3031561 ctcgtcgcgc tgtatccctt gacacttgca ggagcgtaca gatctgctcc gttgtaattc 3031621 ggttatgctg ttttaaaaaa tccaaaatcg ctactaatct ttcttcttgg tacacgccct 3031681 cattcctttt ctcagcaatc atttataagt aattataagt ttttatttga ttttattcaa 3031741 cattaataag tgattttaag taaaaatgcg tcgagagaac caatttttcc taagtaggca 3031801 aaaagaaaga accagtctgg tcgactggtc aattttgagg ggatgatgcg aagatccgga 3031861 taatagtgaa tggatagata acgggaggag caggggtgtc aatcagcagc tttttcccgg 3031921 ggtttagggt ccataaaacg aacagtgtca gccaacactt ctgttacata cacgttaacg 3031981 ccttcctcgt tttcatagct tcttgtctga atccgtccgc ttacgccgac gagagaacct 3032041 ttttggcaat acaacgccgt gttttcagct gtttttctcc aaagtgtgca attgacgtaa 3032101 tcagcttcga tttcacctga agcattcttg aagctgcggt tcaccgcgag cgtaacatgt 3032161 gcaactgccg caccggcgga agtgtagcga agatcaggat cttttgtaag acgtccgaca 3032221 agcatgacct gattgaacat gcgattcctc ctctccttgc ggttgtatgt attgtaaatg 3032281 atgcaacaag aaaagaaaaa cgcttaaaaa tggctttcag cctctgtttt tatctttcgt 3032341 tttcattttt ccttcagcta aaaacatctt ttgctttttt cctttgaaga aatatgtact 3032401 ttttaaaaaa cggaaaaaga tttgctttgt cagccagttt tgcgtattca tgcgcacata 3032461 ggaagagcca tcccacgcaa accactgaaa gctcaatttt ttttccggca ttgacagctt 3032521 gattttatac tgctccatgc catcttgtgt ttcgtataaa aaacttattc ttcctttttt 3032581 gttcagatga acctcaaaca cttctttacg gcttaacata tatgttactt ccttttgaat 3032641 caaatgactt tcagaaggaa cgccgtcaat ataaatttct tttaaacgaa attgattcat 3032701 accacatctc tccgtaatcc atagtcagtt acagtataat gaaaaaatag aaattattaa 3032761 atgtttcgct catacaaaat tctttagccc caacattgca ggattttttc ctcgaaaacg 3032821 tttatgttat aatggaaggc aagaaaactt tggaagtaat cggggtgaga agaaatgaaa 3032881 acctttaaac tggttgacct gaatgtggaa cgagtggaca aggaagaaca atcaattgaa 3032941 cagtttcccc ttattgacgg actgattata aataaagaag acggtgaaaa tcactggctg 3033001 attgaggcgc ttgtacagaa agaacatctg tctttttttg aacagcttca aaacagccaa 3033061 tctgaagcca aagtatttgt aacgatcacg aaaaaaagca atcgccccgc ccagctgaca 3033121 gcagcagtga aaaatatcgt caagctggaa gaaagcattc aggttttact ctacggacaa 3033181 atggtcacaa gaaaacagca gggcactgaa accattctcg agtcccttgt aaaagagggc 3033241 tatacaggaa caaaactcat tgaggcattt aagcaaaaat tataaatatg agggggcatg 3033301 ttccccaaaa cagactcaga accgaagagc atcacaatag acatttagaa tagatatgtt 3033361 ctgcatgaaa aaagctgccg ttttgaacgg cagcttttct cttcgtgctt tcactcttgc 3033421 atatttaatt tgtatggcca aaagaatcaa ccaattcccc tttcacaacg aggcgccctt 3033481 cggttttgac cgccttgtca catgtgatta acgtaatctc ctttttgttt gtctcctcaa 3033541 ctacatctgc atccatttcc gatatgatgt ctttcgatgt tacagaatag atataatcct 3033601 ttttaaaatc cgtgatgaca atttgggcac ctgtttttat gttttccaga ggtccgaaca 3033661 gaagattctt ttgcttcaaa tgatggcccg ccaacggata atttccctca cccatttttt 3033721 gatcccggcg cattgttgcc gcccctatca aaagattttc attggttgtg ccttttacga 3033781 tcggaagctc cagatcgaca cttttaattg ttatccgccg ccttgattgt gaagtaaaaa 3033841 taagtatatt tcacgtgctt tcgacgttct ccacttgact ggaatgcttt aatggcgatc 3033901 ccggcatctg tagcttcagg ctttccttca gaggaatcag aaatctcaaa ctctattttc 3033961 tcagtgttca gcacataacc ggctggcgct ttcgtttcaa caaaagcgta ttgtcccggt 3034021 gcaaggcctg aagctgtgac ttgatgatgc cggatatgac tggtttcgaa gtctgtatga 3034081 aaattcgcga acgattcagc atggttgatc ttccggttct gatcattaca gctgccatta 3034141 tcggccatga caaatacaag gcttttcatg ccggagcgaa tgacattttg caaaaaccct 3034201 atcattactc tgaatttatg gcgcgtattc aaaacctgat aatgatgaaa catacagcaa 3034261 atcaagccac aagaatggaa atggcgtttc tccagtcgca aatcaagcct cattttcttt 3034321 ataatgtatt aaacacgatt atttctctca ctcatttgga tattgaaaag gcccgggagg 3034381 taacagagga atttaccaac tatttaagaa tgagttttga ctttcaaaat acatcagcca 3034441 tcagttcctt cagacatgag ctttcgatta tcaattccta tctttctata gaaaagacgc 3034501 gattcagtaa tcggcttgag gttcttttcg atatagatga agacattgac tttatccttc 3034561 cgcctttaat gattcagccc ttggtggaaa atgccgttct tcacggtgtc agcaagaaaa 3034621 gaggcggagg atggatcaaa ctgacagcta aaaaacaaag caaaaatgag tatcacatca 3034681 aagtagagga taacggtccc gggataactc cggaaaaaca aatagatctc ttatcaacgg 3034741 attttgatcg cagcgtcgga ttgaaaaata tcaatcagcg gctgaaacat ttttgcggaa 3034801 gcgagttgat gatcagcagc actccggatg caggcacctc tgtctcaatg ctcattcatc 3034861 tcgctgaaac aacaggaagc cctaaagaac tgaaggacac agaacgaacc taaacgaaaa 3034921 ttgagataaa aaaagacgcc gtttctaacg gcatcttttt tattccggcg actttgcttg 3034981 ctgcttcagc aggtctctga tttctttcag cagctcctcc tgcgcatcca ccgcttcctc 3035041 cgcagcctct tcttctgctt cttttttgcg ccttaaccca ttcaaagtcc gaatgacgat 3035101 aaaaatggag aacgatataa ttaagaagtt cacaatcgtc tgtataaagc tgccatattt 3035161 cactacagca tcgccaaacg taaacgacag gcctgaaaag tcaagccctc ccagcagcaa 3035221 accgaccaaa ggcataatga tatcatttac tagagatgtg acgatctttc cgaaagcgcc 3035281 gcctatcaca acaccaatcg caaggtctac gatattcccc cgcatggcaa aggctttaaa 3035341 ttcattccac atacaatcac ctgcttttct atatttgtaa agaaaaaaag acaaatgtgc 3035401 cgctggccat ctgccttttt tcaattattc tccgagggca aaagtcagtt ctacttcgca 3035461 aacgacttcg ccatcaactg tggcaacgcc ttttccgcgc ccgattgtgc cgcgggcacg 3035521 aatgatttca acctcaaggt gaagctggtc accaggcttg acttgttttt taaagcggca 3035581 gttatcaatg cctgcaaaaa aagccagtct gccgcggttt tcttctttaa tcaacatcgc 3035641 aacagctccg acttgagcga gtgcttctac gattaatacg ccgggcataa ccgggtactg 3035701 aggaaaatgt ccgttaaaga actcttcatt agcggttaca tttttatagc cttttgcccg 3035761 tttgccctct tcaacttccg taatccgatc cacaagcaaa aacggataac ggtgaggaat 3035821 aatttcttta atttgctgag tatcaagcat tgtcttgaca tctccttcat ctgcattagt 3035881 atgtatagca atcatcaaag atccaatctg tacatttgaa aagtatatta tgaattaatc 3035941 tctttttcaa ccgcgctaaa atgtaaccaa ctgtcaatga gagccgtcaa aagttatgat 3036001 atgataatta tagattttac caatagcaaa gaggtaggaa aatgatttcg aagtttattg 3036061 aaaaaagaat gctaaacatg ttagacgagt ggtattccgc aatgagcaaa cgcaaaatga 3036121 atcacgtttg cacactgaaa gagaaaattg atcagcacct tccaaagatc aaaaagaaca 3036181 caaaactttg gatgcgttat caattgtttc aggcccgcca tcagctgctt tttgaaaacc 3036241 agaacggact cgattcattg ttcgatggcc tatatggcct ggaagacaaa atggatgatg 3036301 aattgaaata ttatctgtat tttttctctg ggttatatga gatggtaaaa acagctccga 3036361 aacatgcagt acatcatttt aaaaaagctg aacagtacct ggccgccatt cacaatacgt 3036421 ttgaagccgc tgatttatat tatcaaaccg ccggcgccta ttacttgatg aaatcaccgc 3036481 cgctttccgt ccaatacgtc aaaaaagcat tacacatcta tttgcaccaa ttcggctata 3036541 tcaaaaaggt aatcacctgt aaacttttgc tcgccgtgaa ttatattgat caagaacgct 3036601 atgaaaaagc tgaacagctt ttcaaagaaa tcattaagaa aacccagcaa ctacatgacg 3036661 aaaacctgct atgccacgct tattataacc ttggcttttt aaaagcgacc gagaaaaaag 3036721 accaggaagc gcttctttac tttagaaaag tattaaagaa tcaagaattt gaaatgaatt 3036781 caccagtctc atatcttcat tgtgtgtacg agtctgtcag agcgcttttt aaaacaggga 3036841 acatcacaga agctaaagcc gtccttcaaa aaggaaaaga attatctgaa aaggtagaca 3036901 ttcaaaccat ttatttaaaa ttaaaaacgc ttgaagccct ctacacatca gccgaagacc 3036961 cttatgagca gctgctcgaa tatgtgcttg aattagaaaa aatcgaggcg tgggtggatt 3037021 tagaagtgct gttagaagat attacggaat actacaaaaa aaaggacgat ttcgaaaaag 3037081 ccgctttttt tatcatgcgc ggctgattga aaaacgccca ttttcttatt atctgactga 3037141 attgattaaa ccgagcattt gatctcccat tgtgatcgtt ctgctgttca gctgatatga 3037201 acgctgggac gtgatcaaat ctgtcatttg ttctgaaata tcgacattgg acatctcaag 3037261 tgagccctgc tgcatgccga tgttttgtct attagcgccg ttcagctctt caaaagctgc 3037321 cgcattatca atagagaaaa ggttattccc ttcggatttc agctcttgag ggttattcac 3037381 ttggacaacg ccaagattaa accgctgaac cgcgtttccg tcagatgcgg ttaaggtgcc 3037441 gttcttatta atggtgatat tcttcattga gctgtcgatg ttcactgtat tgccgttctc 3037501 atcaagtacg ggatacccat ttccagtgac gagctgcagc tggttggcat tcgcagcgga 3037561 cggcgttaca tacagcgccc cgtccctcgt atactggcgg tttccattta catttacctg 3037621 aagatactgg tatggagacg taaatgcgat atccagatcg cgatcggtct tctgaatgct 3037681 tccttgatca gagactaggc gtgaactcat catcgctccg acgccaaggc gcaagccggg 3037741 cggcgttttt cgggcttttg ccacttcctc gtttttttca tcaacctgat cgaattgctg 3037801 tctgacaagc tcagaaaaat tcgtatcttt tgccttatag ccggttgtgt tgctgtttga 3037861 aaggttgctg ctgattgtgt caatctgctg ctgcagctgg tttaaggttg ttgatgccgt 3037921 tagcattgac ctgagcatag ttgatgtccc ccgttttttt cttccgtttt cttaaatttt 3037981 tccaatttca tttgctgctt tatccatact tttatcgtaa gcctgaataa ccttctgatt 3038041 cgcctcaaac gatctgtacg cttcagtcat ttctgtatag gcgcttgtca catccacgtt 3038101 tgaaagctct gagacgcctt gttttaatga ataggctacc tgattatttc cggctgcgct 3038161 tggcagatca ttaccgtccg ccgtgctgta caaatcattt ccgtcccgtt tgagattgcg 3038221 gacatcttcc gccattctga catcaatctg gccggctgtg cgtccgttcg ttgtcacagt 3038281 accgttttca gacacagtga aattctcatt atcaacagtg attggctggc gatccgtcga 3038341 taaaataggg cgtccgttga tcgtcagctg attgttctca tttagtgaaa atgtgctgct 3038401 ttttgaataa cggattccat ccgctgtttg aaccggataa aaaagagcag ctttttcatt 3038461 ggtttccgca ctcatcggaa cttgattttc gatcaatgca atgtctgtag gctggtctgt 3038521 ggacttcagg cttccctgtg taaagagagg cttgagctcc tgcatatata ctccggtatt 3038581 cacggaaccg atttccgtcc ttgatgtccc ggccggagat tttgattcta ttctgctgag 3038641 cagcatctca gggaacgcgc gcatagagcc ttgatcagct ttatatcctg atgtatttgc 3038701 gttagcaata ttatttgaaa gcatttccgt tcttcgctgc tgggcaatca ttgcggatgt 3038761 tgctgtatat aatcctttta acaaatttcc cacctctaaa aatggcattt tttccagttg 3038821 tcatatagga acgttcgttc tataataaaa actcagtatt ttatcctatt atcgtcattt 3038881 aacatctttt cgtgaaggct ttttcataaa aaaacctcat tctttttcag aatgaggttt 3038941 gtgaaatcag cttagtttgc gtttaggaag cttgtccata ttatcaagca tgacacctgt 3039001 gccgatggct acgcaatcca taggattttc agcaacgagg accggtacct tcagctcttc 3039061 agcaagcagc tggtcaaggc cgtttaagag cgcgcctccg ccggtaataa taacgccgcg 3039121 gtcaataata tcagcagaaa gttcaggcgg tgttctttcg agcacttgtt ttgcagcctg 3039181 aacaataaca gcgacagatt cacgaagggc ttcttcaact tctttactgt ttactgtaat 3039241 tgttcttgga agaccggaaa ccatgtcccg tccgcgaatg gaaatttcct cgtgacgtgc 3039301 gtctgggaaa acagttgcga ctttaatctt aatatcctcc gcagtacgtt cgccgatcag 3039361 cagcttgtac tcgcgtttga tataatttaa gatttccatg tcaaacttgt ccccagccat 3039421 tttaatagaa gaggaggtga caatatcgcc cattgaaata accgcgatat ccgtcgtccc 3039481 gcctccgatg tctacaacca tgttaccgct tggctggaat atttccatac ccgcgccgat 3039541 agcggcaact ttaggttctt cttcaaggta cacatgtttc ccgccgcttt tttctgcagc 3039601 ttctttaatt gctttttgct caacggatgt aatattcgtc gggcagcaaa tgagcatgcg 3039661 cggctttgag aacaggcctt ttacattcag cttgttaata aaatgtttca gcattgcttc 3039721 tgttacttca aagtcagcaa taactccgtc tttcagcggg cgaatcgcaa caatattccc 3039781 aggtgtacgt ccaaccattc gtcttgcctc ttcgccaacc gccagcactt tgccgctgtt 3039841 tttatcaagt gcaacaacgg aaggttcatt cagaacaatt cctttacctt taacatggat 3039901 cagtacattt gcagtaccga ggtcaatacc aatatccctt gcaaacatct atttatatcc 3039961 tccttgaaaa tctgtttcac agtaaatatc cacattgtgc cctaattata tatattatca 3040021 taaaatatag aaaaaaagtt ggaagcacaa taagttcttt acaaattttt gcggatgttt 3040081 tatgaacgat ttcaagaagg caatgccagg tgattacgat tgctgaacag gctctccttc 3040141 gagaatttca tcttttttat atttgagctt tgtcgcttct cctcctctta aatgcctgat 3040201 ggatttatga taatcgagta tttctttcac ttcgtttgcc aagtcggggt taatttcagg 3040261 cagacgctct gttaaatcct tgtgtactgt acttttggaa acaccaaatt ccttcgcaat 3040321 gacacgaacg gttttctttg tctccacgat gtacttccct atcttgattg ttcgctcttt 3040381 gatgtaatcg tgcacaccac tcgacctccc taaaatggat gtgagaagtg tgaaatgaga 3040441 tccgtattct gtaaagagtc gttcattatg ccgcttcttc gttgtatggt tttaaaagta 3040501 agtttgtgaa atatgcccac gatccctcac ctcaaacact ctctttgtta ggtttgtaac 3040561 agtgtattag cattcttttg ggaatatgct aaaaactcaa taaggacaag gggtgaaacg 3040621 aactttttca gattcagcaa actatttcgc gtcactaaat tttcatcttt acaactattg 3040681 atcgctcctg taaaatgaaa taagcaatta gttacttagg taagtttttt agaaggagac 3040741 cgacatgtcc tacgtcaaca gacacctcat tcatcaaatc aaccaaagcg cccgcctgat 3040801 tgccaagaaa gccaatgaac agctagagcc attcggcctt tattcatctc aatggtcagt 3040861 tttatattgt ttgcgtacga tcggaccaat gactcaaaaa gagatttggt cctatttaaa 3040921 tgtggaagcg ccgactgtga ctcggacgat caaacgcctg gaggagaacg gctgggttca 3040981 gagacggcaa ggtgaagaca aacgggaaaa acttgttgtc ctcacaaaag aagccgagaa 3041041 aaaatacgaa gaaatcaatg tgaaaatgtt gaaattcgag gaagagctgc ttgcagattt 3041101 ccgggatgaa gataaagaag ctttttctca tttattccgc atgtttttac aacaatgaaa 3041161 ataaggaagt gacatacatt tgaaaaaagc ggatgcgata tggaccaagg attttattat 3041221 ggtcctgctt gtcaatttat ttgtgtttgt gttcttttat acatttttaa ctgtattgcc 3041281 gatctataca ctgcaagagc ttggcggcac agaatcacaa ggcgggcttt taatcagcct 3041341 gttccttctg tctgcgatca ttacacggcc tttctccgga gccatcgttg agcgtttcgg 3041401 gaagaaaaga atggcgattg tatcaatggc gctcttcgcc ctatcatctt ttctgtatat 3041461 gccgattcat aacttttccc tgctgctcgg attgcggttc ttccaaggga tttggttcag 3041521 cattttaacg actgttacag gtgcaattgc cgctgatatt attccagcca aacggcgcgg 3041581 tgaagggctt ggatactttg ccatgtctat gaacctcgct atggcgatcg ggcctttcct 3041641 tggcctgaat ttgatgagag tggtaagctt tcctgtattc tttacagcct ttgcgctgtt 3041701 tatggttgcg ggcttacttg tttcgttctt gataaaagtg ccgcaaagta aggacagcgg 3041761 cacgactgta ttccgttttg cgttctcgga tatgtttgaa aagggcgcac tcaaaattgc 3041821 gacggtcggt ttgtttattt ctttctgtta ttcaacagtc acatcatatc tgtctgtatt 3041881 cgccaaatca gttgaccttt cggatatcag cggatatttc tttgtttgtt ttgcggtgac 3041941 aatgatgatt gcacgcccgt tcacagggaa attgttcgac aaagtcggac cgggcattgt 3042001 catttatcca tcaatcctga ttttctctgt cggactctgc atgctgtcct tcacacatag 3042061 cggcttaatg cttctgcttt caggggcggt tatcggtctt ggctacggat caatcgttcc 3042121 ttgcatgcaa acattggcga ttcagaaatc tccggctcac cgctccggtt ttgcgacggc 3042181 aacgttcttt accttctttg acagcggaat tgctgtagga tcgtatgtat tcggattgtt 3042241 tgtagcatct gccggcttct ctgccattta tttaacagcg gggctgttcg ttttaattgc 3042301 tctgcttctc tacacgtgga gccagaaaaa acctgcagag gctgaaggaa aagtgtctat 3042361 tgcagaataa cttgtcagac tgccgggaaa tcccggcagt cttttttcca ttaaaacacg 3042421 gcgccctctc ggttgaacga gagaacgccg cttatagcaa ttattcaatg acaggccgcg 3042481 caggtgaatc aggatctaac gaaaaatcat aggacgcttc atcacgaaac atcggatcgg 3042541 catatatgga ttgttgatcg ttttttgttg cttttcgata cgaagaaaat gaatcatatt 3042601 ctttcttttt ccacatccat atgccgtctt gatccgcttc cttgtggtac acgttatgat 3042661 tgaccgtatt accttcgttt tctgtaaagt cgtttccgat aaataatctg gaatcaccgg 3042721 ccgtcaatat attcttttca attgtgttgt ttttcgtatc gtactgcagc agcagctgtc 3042781 cgccgtacag tccctttgtg tcattccggt acataatatt gcgggcaatc agagaattgc 3042841 tggtgccgcc ccgctttttg tcatatcctc cgattgaaat accggtgtac gcattgttgt 3042901 acactttgtt gtctgtgatc tgaatggcat ttgcatactt tcctttgtgt tcagacgttg 3042961 cttcaatccc aatatcgtta tcgtaaactg tgttgttctt aatttcgata tcgtgtcctc 3043021 catcgacata aatcccgccc gctgagtatt catctccata agcaggattg ccgtaagtcg 3043081 agttttgata aactgtattg ttttctacga ctccgtttcg cacgtaatcg tttttatccg 3043141 cggttccctc ataaccaatt agatcaatcc cgatgttatt attgttgcgg accacattgc 3043201 ctgcaactgt gaagccgtcg atattaccgt tcagcacaac tgcttcactc gctccaagcg 3043261 tcagtttctc aactgtattg tcctcgattc ggatgtcttt catgctgcca gtcccataaa 3043321 ctgcgattcc gtgagcattt ccttcatccg ctgttgtctt aatcccccgg atgtgattat 3043381 ccttaatggc gatatgactg ctggaccctg atacataaat ccctatagca gttgcttcct 3043441 cagatgaaac agaaagatct tgaattgtta aaccgctgat ggcaatgtca tgtttatcgt 3043501 gaatacgaat aagcggtgtt tcatattcag cgttcgcaac ggattcaccg ctaatcacga 3043561 cgttttcatt ttcatagttt cggaatgtga taggctttcc gtccgtaccg ctgtgcttta 3043621 catcaagggt ctcatgatac gtgccctccc gaatcatgac agttgtgccg gcagcagcct 3043681 tctcagatgc gtgtgccaat gtacgaaacg gcttttcttt tgttccttca ttttgatcac 3043741 tgccatttgg cgaaacatac agataatccc cagatccttc ctcattcgct tttgtcttat 3043801 cataaacgaa agcgaggatg acagacgtta aaacacccgc caaaagaata aaataccatt 3043861 ttctcatttt cgattcccat ttcgttttag aatagatttc taaaaccatt ataaatgttc 3043921 tatttatgga aaaccatttc aaaaatatga aaatataccg tctaaataga tcttattcag 3043981 cctggcggac ctgcgcatgt tcaactgttt caattgccaa tgatgcaggc gggtgaacac 3044041 gcatcagaac aatgtagaaa agaaaggaaa tcagcacacc tacaaaccaa gaaatatcgt 3044101 ataagctctt caatacagga acatacatgc caatcagcga aatcagcgct cctaacattg 3044161 tggctgcaaa cgcacggtaa ttgtagccct tccaatacac ataccgtcct gtttcggaat 3044221 acaggtcatc taccgagagc tcacgtttgc gaatgataaa atagtcggcc atcatcacgc 3044281 ctgccaccgg tccaagcatg ccgcctatta agccaagaaa cgcatacacg cttgtcgcgc 3044341 tctccatcag cttccacgga accgtaaata aagcgagcaa cgctgtgata aagctgccac 3044401 gtttgaaatt gatatatttc ggcagggcat tcgctatatc ataagcgggt gatacgatat 3044461 tcgccgcgac atttacagag atcgtggcga tgcagagtgt gatcacggac aagacgatga 3044521 cataagggtt atcaaaccgc gccaaaatat cgacaacatc ccaaatcggc tctccgaacg 3044581 cgacctgcga gccggaggtc accgtaatac ttgcgaatgc gaacagcgca aacgttcccg 3044641 gcaaaccgta aaattgtcct ttgatttgct ctttttgtgt ttcagcaaac cgtgtaaaat 3044701 caggtatatt taagatcaat gtcgcccaga tgccgatgat gccagtaact ccggcagcaa 3044761 acggccagaa tgtttctgaa aacgtatgaa actttcctgg ttgagagtat atcgggccca 3044821 atcctccagc aatatcaacg gcccaccata ccatgccgcc aaataccaga tacactaaag 3044881 gccctgccca cacctcaaaa cgtttaatcg actccatgcc gtgatgcaat acgagtaaat 3044941 gaatggccca aaagaataca aaggaaagca aaccggacaa gtgaatgccg agaatgttcc 3045001 actcgccgcc aatttctccc caacctggcc acatattcaa aagcaaaatg ttcagtgccg 3045061 tgctacccgc aaaggtctgg atgccaagcc acatgatagc tgtaaacgcc cttagaagcg 3045121 cggggatatt cgcgccgtat atcccgtaag aagcccgaat gatcactgga aacggcagcc 3045181 cgtattttgt ccccgcatgg ccgtttaagg caagagcgcc aaataggata agtgatgccg 3045241 taataatgat cgccagcacc tgccaaggcg aaaggccgat cgcaattaat cctcccacgg 3045301 tcgcgtaggt cggtatgtta tgtatacatc ccatccaaat ggaggcaaag ttcattgctt 3045361 tccacgtccg tttttcctgt cccaaaggca ccagatcttc attgctcagc ctgttggatt 3045421 gctgctgact ctcttttaat ttcatagccg gctccccttt ccatattgtc tatatgtcgt 3045481 cacacgttat gttttttgac attagatgtc acttaatata actgaagagt cagacaataa 3045541 cactggctat gatatacaat tttcccgttt gtatttgaac agcttaaaca agaaaaagag 3045601 acagacctca gagcccgtct ctttcttaag atgcagtttt cattaatgca gcaaatctca 3045661 cagccattaa caggcttgct ccgcccgcta taatcataat gattcccatc atatcaaaat 3045721 gggctgccgt gatttcttta ccaaaaagaa tgccaaggat caccgaagac aaaatcgatc 3045781 ctaggtaacg gcaggtttga aacaggcctg aagtcgttcc taccatgttg gaaggactcg 3045841 tttccagcat cgctgcctga agcgcgacat tgcccagtcc gtagcctata cccaagagcg 3045901 acagaatgag gcctttaccg atggtctgga cattgataaa aaagatggtt aagagcacgg 3045961 ctccagccgt catcaaaagc gctcccgcaa agatcggctt gacgacacca gatcggtcga 3046021 tccatttgcc ggttagaggt gacacaacga tgctcattcc agacataaac agcataaaca 3046081 ggccgctcgt ttgaacagaa agatgcattt catcctgaaa gtaacttggc aaaccaaaaa 3046141 ataaacaata gaagaaaaca ttcaataaaa taaactgaac atacacggct gacaggtttc 3046201 gctgtgtttt aaacagacgg acatcaataa acggcttatc cgttttcagc tcgcgccaga 3046261 caaacgcaca gagcagaagc aagccaagca caccttcaac cgcatgcggc gacgtgctga 3046321 acgacagcaa aaaggataga aggaaaatga ttcccccggc aaataaaaca attccaagaa 3046381 tatcgagctg ccgaataatg gttttgattc ctgccccttt tttctgatct ttcgggaaca 3046441 tatacaggcc caataagaag ctgaggataa taaacggcaa attaacgata aagatcgccg 3046501 gccagcctcc ccatacaatc aaaaacccgc cggctgtcgg ccccagcgcc gtcatggcgg 3046561 acgcaaaaat agagagtaca gccaaggctg aagcttggcg ctcatgaata tgattccgaa 3046621 tcaagccgac acctgacgga taaatcgcac tgctccccac cgattgaaac agccgcatga 3046681 ccaataatgt cataaacgtc ggcgcaaacg gcgccccgat ggcagaaacc gcaacaagaa 3046741 taagcccgaa taaaaacaag cgtttccgcc caatcaaatc accgagcttt cccgttacgg 3046801 gctgcgctac ggcactcgcc aagtaaaacg aggaaatcag ccaggaaacc gttgtaaacg 3046861 agaggtgaaa ctcatgctgg atgctatgga gcgcaagaga gatcatagac gagttcagcg 3046921 gattcagcat tgttcccgaa gccacagctg ttaaaaaaac agctcggctt tttttcgata 3046981 acatcatttc acttgttcca gaaactcttc cgttgtccgc gatttaccga ttctcgggaa 3047041 aataaagcgc agtgtggctt catgctcttc atcgctaaat gtggacatgg catctgtaat 3047101 aaaaatctgc tgatagccaa gctgaaatgc ctcccgtgct gtgctttcca ccccgatatt 3047161 cgttgcgatg ccgcacaata caatcgtatc aatgccgcga cgtctcagct gcaagtctaa 3047221 atctgtgcca aaaaaagcac cccattgccg ttttgtcaca gtataatcgc catcctgcac 3047281 accgatttcc ggaacaaatt cggcccagtc cgccggcatt tcccctgaac ctccctgcgc 3047341 aggctcatcc gtttgcggct tcagggcgtc cgctccatca tgaaaggcta catttacaaa 3047401 gctgatgaac ccgttatgtt tccgaaattc atctacgagc tttttcgcgt tcgggacaac 3047461 ctggccgctt tgatcaatcg gcacaattcc cttttgtaaa tcaatgataa ccaatgctgt 3047521 tttttgaaaa tcaatgttga gtgtattcat catacgtctc ctcctgatac tgttagtgtt 3047581 tctcacattg catattttac tcttcacact gcctaagttc ttttatgatg cttgtgaaat 3047641 tctcagaagg agcgttttct catgattttt cttttatgta gtagtaacag gttgtgcata 3047701 cgaacaaacc ggcaagcact gtaatcataa agggcgtcat cgcttcatca cctgcctgct 3047761 gtctatcggt tcctgcctga aaatgcccat gaatttgcgg cggtccatcc aaagcaggat 3047821 aagacacata accattaata tcgtgctaag atcctgcacg ccaatatcaa aacaatagtt 3047881 aatcaagacg atgttcacaa taatgggcat aaaaataacc gcccctaatg cagccgttcg 3047941 cggaatcagt aataaaacag ctgccaggat ttcaccaaaa cctataaaca gttcatagac 3048001 atgagaataa ccgaaaaatg tccacgcgat cgtaaacccc ttcccggcag ccgcctcgat 3048061 ttcaggcgtc acctcgccaa actggccaat taccactttc gccagaccgt acacgaaaaa 3048121 attaaaggct aaaaacaatc ggaacgtcgc gggaatcgac ttgcgtaccg ctttcctcag 3048181 cctgccgcct ttattcatca tacatccccc tcagtgtatt atttgatgta gtacacttaa 3048241 tacagtatag agtattctaa ttaatgtcaa ttcccttttc agctcatatg aatagtttct 3048301 tttatagata caaagtctta tatcgcaaaa aatgccattc tccttccttt ccatccctcg 3048361 ataacatttc tcaaaaacca tgtcaggaaa tcttacatga aaatgtttta tcattctttt 3048421 ttctctataa tgaagaaata taataattgc tttttattct gaaagatacg gaggaatgag 3048481 acatgcaaat gggcgataca gtttttatgt tcttttgcgc tttactcgtg tggctgatga 3048541 ccccgggatt agcgttattt tatggaggaa tggtaaagag caaaaatgtg ctgagcactg 3048601 ccatgcacag tttctcttcc attgccatcg tttccatcgt ttgggtgctg ttcggatata 3048661 cacttgcctt cgcaccaggc aattcaatca tcggcgggct ggagtgggca ggcctcaaag 3048721 gggtcggatt tgatccggga gattacagcg ataccatccc ccactcgtta tttatgatgt 3048781 tccaaatgac gttcgccgtt ctgactacag cgattatttc cggggctttc gcagagcgga 3048841 tgcgattcgg cgcttttctt ttattctcgg ttttatgggc ctctttggtt tacacacccg 3048901 tagcgcactg ggtatggggc ggcggctgga tcggccagct tggagcgctc gatttcgctg 3048961 gcggcaatgt tgttcatatt tcctccgggg tggcaggact tgttcttgcc attgtgctcg 3049021 gcaaacggaa agacggtaca gcgtcttctc cgcataacct catttacacc ttcttaggag 3049081 gagctttgat ttggttcggc tggttcggct ttaacgtcgg cagcgcattg accttagatg 3049141 gtgtggccat gtacgcgttc atcaacacaa acaccgcggc tgcagccggg atcgccggct 3049201 ggatcttagt agaatggatc attaacaaaa aaccgacaat gctcggagcg gtatctgggg 3049261 caatcgccgg gcttgtcgcc attacgccgg ctgccggatt tgtcacaccg ttcgcttcca 3049321 ttattatcgg catcatcggc ggagctgttt gtttctgggg agtattctcg cttaaaaaga 3049381 aattcggata cgacgacgcg cttgacgcct ttggcctgca cgggatcggc ggcacatggg 3049441 gcggaatcgc aacaggatta ttcgcaacaa cctctgttaa ctcagcgggc gcagatgggt 3049501 tattttacgg tgatgcaagc ttaatctgga aacaaatcgt cgccatcgcc gccacttatg 3049561 tttttgtatt tattgtcact ttcgttatta ttaaaattgt aagcctcttc cttccccttc 3049621 gcgcaactga agaagaagag tcacttgggc ttgacttaac gatgcacggg gaaaaagcat 3049681 atcaagattc tatgtgagga gtgacgctat gagcggtcaa atgttcaagg tagaaattgt 3049741 aacgcgtccg gcaaattttg aaaagctgaa gcaggaactc ggaaaaatcg gagtgacctc 3049801 tctgactttc tccaatgtac acggctgcgg ccttcaaaaa gcacatacgg agctctatcg 3049861 aggggtaaaa atagaaagca atgtatacga gcgtttaaaa atagaaattg tggtcagcaa 3049921 ggttcctgtt gatcaagtga cagagaccgc taaaagggtg ctgaaaacgg gatcaccagg 3049981 tgacggtaaa atatttgtct atgaaatcag caatacgatc aacatccgca caggcgaaga 3050041 aggacctgaa gcactttaat atcggtacga gattcggaca ctccggatct ctttttttgt 3050101 gcacagaatc cccccagaaa ccgcgattcc tcttcgaatt ctcttcaagc gccgttattt 3050161 cagacaatct ctatttttat ttgaaacttt tcatgagtaa gattagtcta ctaaatataa 3050221 aaatgtaaaa ggtgattatt tgaactacga aatttttaaa gcaatccatg gactatctca 3050281 tcacaattca gttctcgatt ccattatggt cttcatcacg gaatatgcca ttgtcgccta 3050341 tgcccttatc ctattggcaa tctggctgtt tgggaacaca caaagcagaa aacatgtgct 3050401 atacgcaggc atcacaggaa ttgcaggcct tgtgatcaac tatttgatta cgcttgttta 3050461 tttcgaaccg cgcccgttcg ttgcgcatac agtgcataca ctgattccgc atgctgcgga 3050521 tgcttcattt ccaagtgacc atacgacagg tgcattagcg atttctattg cgatgctttt 3050581 cagaaaccgc aaaatcggct ggccgcttgt catttttggg cttttgacag gcttttcgag 3050641 aatttgggtg ggacatcact atccggtaga tgtattgggc agcctcgttg tcgccatcat 3050701 tatcgggttc cttttcttta gattttcaga tctgcttcgc ccgttcgtcg atttggtcgt 3050761 gaggatctac gaagccatta tcaataaact gacgaaaaaa ccaaccgatc aaaatttcta 3050821 agaaagacaa aagccggcgt ctgaaatcaa gacagccggc tttaatattt ctcatacatc 3050881 tcttgttttc ttcgcttcgc caacacatat aaaccataaa acaacccaat tccaacagca 3050941 tcgatgagca catcccggat acaaccattc ctgctgaaga agagctgaag aacttctgtg 3051001 aaaaaagcaa acgcaaatga gccggctgca gctgatctta tgctgccccg ctgtttccac 3051061 agcaaatatg tcagcacaaa gaaggaaaac gcgtgtccga ttttttgaat aaacgcttca 3051121 ggtacagtaa gctcagtaaa atccataact aaaaattgag acagatcagg gtgcggctga 3051181 aaatgaaaag ccaccgtttg cgatacgacc atgccgctga agctttccgt acagacagaa 3051241 agcaggataa aaaagatcca gcctgcgagc aataggcggt tcatgacata acctccttta 3051301 taacgtacgt gcctacatgt aactacatag acggtaaaac aaagcaaaaa gtaacagaaa 3051361 aaaacgccca tcacaaggat agacgttttc ttcattaaga ctgttcagtg tcttctgttg 3051421 tgctgctttc tttagaacca gatttgtcag ttgaatcatc ctttttctca ccggattttt 3051481 cttctgttcc tttttcagtt gatccgtcct ttttctcgga agattgctga atggattctt 3051541 ctgtttcttg ggtggcagct ttttcaatag aagaaactgg tttgtccata aagtttaacg 3051601 gattcattgc aaccccatct ttacggattt caaagtgcac gtggtttccg ctgtcttcac 3051661 tgtaaaggtt cttgccagat tttccgatca cttgattttg ttttactttg tcaccttgct 3051721 ctacgcttac ttcggaaaga gattgataca cagtcgataa accgtcggca tgttctactt 3051781 ccacaacata tcccagcact ggatcttttt cagctttaac aaccgtaccg ctcagagaag 3051841 cagagacatc gaaatctttt ccgtctttct cagctaagtc aattcctttg cttaggctgt 3051901 acgtgttatt ataggtaacg agtgctgctt ctttctcttc ttttgcggca tcggtttcat 3051961 agaacttttt cacaacagaa acgttttcag aatcaacaac cggcattgcg acattttcca 3052021 ttgactttcc tacttcaact gcatcgtcgt tgttgtcata tgcggagttt ccgccgttat 3052081 cagccaactg atcctttacc tcatcatttg atactgattg ataccaaagg acagctgtta 3052141 aaatgacggc cgcactgact aagtaaattg cagggaacac ccagcgttta cgaaaaaact 3052201 gctgaagttt tttgacttga gaagttttct tttcttcctc tctcattgtt tcatcacctc 3052261 agcaacattc tgaacacttt tctgaaaata tatacaacct atccaaaaaa acttttttag 3052321 atgtagtttg cacagactga acgaaaatat gtattttttt gagaggagtg ccaaaaacgt 3052381 atgaacatga cattgcgtct tgctgaacat agagacttgg aggctgttgt ggcgatttat 3052441 aattcaacga ttgcttctcg aatggtaaca gccgataccg aaccggtaac tcctgaagac 3052501 cggatggaat ggttttcggg acatacagag tcacgtccgc tctatgtggc cgaggatgaa 3052561 aacggaaacg tcgctgcctg gatcagcttt gaaacatttt atggaaggcc agcctataat 3052621 aaaacagcgg aagtcagcat atacattgac gaagcatgcc gcggcaaagg tgttggatca 3052681 tatttgcttc aagaagcgct ccgcattgcc ccgaatcttg gcatccgctc acttatggcc 3052741 ttcattttcg ggcataataa accaagcctg aagctgtttg aaaagcacgg gtttgcagaa 3052801 tggggactat tccccggcat cgccgaaatg gacgggaaaa gatacgattt aaaaatttta 3052861 gggagagagc tttcatgatt agtctggata aagatgaaaa cgaaattgaa catcataatg 3052921 aagaaaatag ccttgttgaa caggagactg cacctgttgg acaggagagc cgccagctga 3052981 gcgcctccgc tgtcaagtcg ctatccgaca ttgccaagtg gggcaaaatt tctggcatct 3053041 tgttaatcat tatgggatcg cttgtcactc tgtctgtttt gatgacagtg attggcgcca 3053101 tcccgggcgt actgctcatt atttcaggcg tatttttgat gcgctcagca aaagcagccg 3053161 cggaagccga aggaaatcta accggcagcg ctggcgaaag catgcttgaa aattacggga 3053221 catttataaa aatgcagctg ttttatgcag catccagtat cgttactgtc ctgatcggga 3053281 tcattgtagc cattttcgtg ctggtggtaa tcggcattgc tgcttttgag aacacgcctt 3053341 cgtatgatga tccggattct tattattatg aggatgatcc ggtgtttgaa taatgatgag 3053401 acaggacagg gcatgagttc catataaacg gaaccatgcc tattttattt gactattcaa 3053461 agcaggccgg cgtaaacacc aaatcctgaa gcaagcatac aatagacatc tctagtagag 3053521 gaaatcaaca aagcaacgct gttacccaga aatgaatatc aaaaaaacgg atgaagtcgg 3053581 aatcaatccg aaaccgcact ttttatttcg ggtgtctgca tgcaaaaaaa cacacccgga 3053641 tcgtctggaa aatctcaaca atccgggtgc agatcttctt taatacattt ttttgcgtct 3053701 gtcttcctca gtcaaaaatt caacaaaact ccgcatcgca aaaggctctt cctttatttg 3053761 tcgtgcgtag gagcttttcc gctcttctga aaggatttcg ctctttttga tcctgttcag 3053821 catatagatg tgaaccgttt tttggatttg tttatgctga tagcctgcct ctttaaaaaa 3053881 tgcgagcccg agcgccgcca aaagggcgaa tatgcctgcg ctgatcaggg actccctgtc 3053941 agctgaagca tgaaatagaa aagcagctaa attaaagaga gagaatgcag caagcggaat 3054001 agcaagaaaa cggtaaatga cggttttttt catgaaaggc tgtacggcct tttgaatttt 3054061 ttgcatttct gttttgatga accccggcat ttgttcgact ctgtaaaagt tcatataatc 3054121 ctcccccttt atttgatgtt tcaagcttca cgaacgttat catatgtgtt tattttaacg 3054181 caggtgcaag ctggttttaa agaaatctgc ccgtattttt cacgaagaat ctggatcgcc 3054241 gctctttatt cttttaaaat gtgagtgtta taatttgtaa tgggaatcag atcactgtta 3054301 ttcatggaat actaatggca atcttcttga taaatatgaa tgagcggggt tacaaagtga 3054361 gtatttcttc catcctttta tcactttttt tcattttaaa tattcttttg gccatcattg 3054421 tcatcttcaa agaacggcgc gatgccagtg catcttgggc gtggctgctt gttcttttct 3054481 ttattcccgt tttaggcttt attttatact tattattcgg ccataatctc agacgcaagc 3054541 atttgtttca atgggaagac cggaaaaaga ttggaattga aaggctgctg aagcatcagc 3054601 ttgaagattt agaaaccaag caatttcagt ttaacaaccg ggcaaccttt gataacaaag 3054661 atttaattta tatgctgatt atgaataacc atgctgtgtt tacagaggat aattcagttg 3054721 acgtcattac agatggacgg gataaatttc agcggctgct gagtgacatt tcaaaggcta 3054781 aggatcatat ccatttacag tattatattt ataaaggcga tgaattaggc aaaaaattgc 3054841 gggacgctct catccaaaag gcgaaagaag gtgttcaggt cagagtgctt tatgatgaac 3054901 tcgggtccag aacgctgaga aaaaagtttt ttaaagagct tcgcgaggct ggcgggcatg 3054961 tggaggtctt tttcccgtca aagctcaggc cgattaacct gcggctgaat taccggaacc 3055021 atcgaaagct tgtgatcata gacggtatga ccggttatgt cggaggcttt aacgtcggag 3055081 atgagtatct agggcttaat ccgaaattcg gttattggcg ggatacgcat atccggctgc 3055141 aaggaacggc cgtgcacgcc atccaaacac gattcatcct tgactggaac caagcttctc 3055201 atcaccatac gctgacatat attccaaatc actttcctga ttacggccca aaaggcaacg 3055261 tcgggatgca gattgtcaca agcggccctg attcggaatg ggaacaaatt aaaaatggct 3055321 acatcaaaat gatttcgaac gccaagcgtt ccattttgat acaaacacct tattttatcc 3055381 cagatgcaag cctgctggat gctttaagga tcgcttgcct ttcgggcatt gacgttaaca 3055441 ttatgattcc gaacaagccc gatcacgcct ttgtatactg ggcgacactt tcgtatatcg 3055501 gcgatctgct gaaagccgga gccactgtct atatttacga taacggcttt attcacgcga 3055561 aaaccatcgt ggtggatgac gaaatcgctt cagtcggcac agcgaacatt gatgtccgaa 3055621 gcttcaggct gaattttgag gttaatgcat ttatttacga tatcaccatt gctaaaaaac 3055681 tggtttcaac ttttaaagaa gatttgctag tatccagaaa attcacctat gaggagtatc 3055741 tgcagcgccc gttgtggatt cgaataaaag aatccgtctc gcggctgttg tcgccgatct 3055801 tataagatgc gtaaaccccc ggcctttacg gccgggggtt ttcctgatgg tcacagtaaa 3055861 tgatgattgc ctcccgcaaa aaagcggcaa gaccttctcc atattgattg attgaatcgg 3055921 taaatcgctc gtcagtgata tacacttccc cgagtcctct gaaaatgtcg agtgtgcaat 3055981 cgtaatgata ttggcaaata tgatcgcgaa atgcccccac agcggcctga atctctgcat 3056041 catcgggccc atgcttcatt cgcgccgcaa ttcgtctgta aatcgaatca aattcagcca 3056101 tgatcgtgcg ccaatcatct gccgagtatg cagatgtcct tttctctgtt tcttctgcga 3056161 tttcctttcc atacagcttt ctgacttcat cagcgtatgt ctgctggtgc tcttcaatgt 3056221 ctttcatgct taatccggca aataaatccc tcttattcat cgtttcccct ccatcaacgg 3056281 acaaaagcgt cctgtcaatt gtttgaatca tctcatccat tctttgtttt ttcttcatca 3056341 atatctcctt ttgcgactga agtgccgctt tccggtcaaa attcggatga tccagcatct 3056401 ctttaatctc atccagacga aacccgattt ccttgaaaaa taaaatctgt tgcagtcttt 3056461 ccaggtctgc gtcactgtac aaacgatacc cagcatcagt aagcgctgaa ggattcagaa 3056521 gctcaatatt gtcatagtga tgaagcgtcc gaatgctaac gcctgatatc tccgccactt 3056581 gtttaacttg atatttcata cataacacct cctctttttt atcgtaaaca atcacgcaac 3056641 gttagggtca atccccaaaa tgttattttc tatatacaaa acttctcaca aatagtgtat 3056701 aaaagaaaag tgagtatttt tttgtaaagg ggagccagta tacatgaatc ctgaaacaat 3056761 gaacaaaacc ctcatcagca tttcgaaatg gggaaaagct acaggcattt tatttattat 3056821 tatgggcgca attaccgcgc tttcaggcgc gttctttttt ctaatcggtg ccgtgccagg 3056881 cgtactgcaa attatttccg gtatcttttt gatgaggtca gctagggaag caggccaaat 3056941 ggctgaacac aatagcggac agtctgaaga cttaatgctg gagaattacg cgaaattcgt 3057001 aaagatgcaa gggatttatt tgatcgtaag cattgctgta tccattcttg cgattatcgc 3057061 cttcttcatc tttttaatgc ttgggattgc tgacggcctt ttcagcgata cgtacagcac 3057121 ttattaatga gaaaaacccg gagctggctc cgggtttttt attattccgc ttcgcttacc 3057181 actgtgaagc gttcattttt gtgttcggga tgttcaagct cgtccaacac ggcaatggca 3057241 taatctgcat agctgatata gctgtctcct tttgcattta cgatgacatt gtcttttcct 3057301 ttttggtaag agccagtccg ttttcctgct ggatcaaaaa atgccgcagg actgaggaac 3057361 gtccaggaaa tggagtctgt ctgctgcaaa tctttcaggt tctcgccttg atttgatgca 3057421 gttggcaaat attctttcgg aaattccggc gtatccatta aacgggttgt tttggcttca 3057481 tcaacaaaca ggcttcccgc tccgccaaca acaagcaatc ttgtgtgctt cgcgtccttt 3057541 aaaatgctga tgagtgctct tcctgcttca acatgaagat gttcttggcc gggtgctgct 3057601 ccaaaagcgt ttacgaccgc gtcgaaaggc ttgatgtctt ccgcagtcag ttcaaacaca 3057661 tctttttcca aaatcgctac gtcttgctcc tgcacttttg aagcgtttct gacgatggct 3057721 gtcacttcat ggcctctttt tttcgcttct ttcaaaatct cgtttcccgc tttcccgctt 3057781 gcgcctataa taccaatttt catttttcat ttcctcctta tttgtaacaa ttttagttac 3057841 atgttagcgg tgagaagtca tcccttttga ttaaaagaga tgattcataa catcttttaa 3057901 tgacttgctt gccagttcat tttccatcgc tctttgcaca ctttcaaacg tttcatccag 3057961 agcgttctga atttttttcc ctaccggaca tttcggattc gggttttcat gaaccgcaaa 3058021 gagttcttct tgcttttgga cagcccggta cacttctaaa agagaaatat cagcaggatc 3058081 ttttttgagg cttgcacccg gcaccccggc gcgtgatgtg agaatatcag cttttttcag 3058141 caggctgatc attcttcgca caactaccgg attcgtgttg acactgtctg caatgatttc 3058201 tgaagatgtt ttttcatcca tcgagatgag ggataaaata tgaatggcaa cagcaagacg 3058261 gctgttaatc atgttttttc accaccgttg taactataat agttacattt gattcgtttg 3058321 tcaacatcta atatacacta aatacatggg ttttgtgcac cgtttttagt caatagaacg 3058381 gccggatgca ctccggccgc gtcttatcaa aataagaaat atctttgtcc aagtgggaca 3058441 taatcgacag gctggcaaga caattcctcc ccgtcagcaa agacctgata ggtttttgga 3058501 tcaatctcaa tcttcggcaa agccgaattc agcttcatat ccagcttgct cagctttctg 3058561 atatttttga ctggagaaat ccttttttcc agccctaagc tttccgccac accacgctct 3058621 atgcttgcct gagacataaa tgtaatcgag gttgagcggt tggcttttcc gtaagacgca 3058681 tacatttggc gcatgaaaac cggttcagga gtcgggatgg acgcgttcgg atctcccatt 3058741 tgcgcacgtg caatcatgcc gccctttaag accagttccg gtttcacgcc gaaaaatacc 3058801 gggtcccaca gaacgagatc agcaagcttc cctttttcca ccgagccgac ctcatggctg 3058861 agcccgtgcg taattgccgg attaatcgtg tatttggcaa tgtaccgttt tgcgcgcaca 3058921 ttgtcattcc cgttttcacc ggcaagagcg ccgcgctgtt ttttcatttt atcggctacc 3058981 tgccatgttc ggatgatcac ttcaccgacc cgccccatcg cttgggaatc cgatgatgtc 3059041 atgctgatcg cacctatatc atggagaata tcctccgcgg caatcgtcgc cgccctgatt 3059101 ctggaatggc tgaatgccac atcttcaggc actttcgcat ctaaatggtg gcagaccatc 3059161 atcatgtcaa gatgctcatc catcgtatta acggtataag gaatggttgg cgttgtagat 3059221 gacggcagaa tgttcgcgta agaggcgagc ttcataatat ccggagcgtg accgccgcct 3059281 gccccttcaa tgtgataagt atgaataacc cggtccccga tcgcgtcgag cgtgttttcc 3059341 aaaaagcccg cttcgttaat cgtatcggta tggatggcaa cttgaatatc agcctcgtcc 3059401 acgacttcca tacacgtttt aatggcgctt ggcgtcgttc cccagtcttc atggagctta 3059461 agaccgatgg cgcctgcttc cacctgctcg atcagcggcg ctttatcgga tgcattccct 3059521 tttcctaaga agccgacatt gatcggaaac tcctcggccg cttccagcat cctcgccata 3059581 taccacgccc cggacgtaca tgttgtcgct ttgcttcctg tagcgggtcc tgttccgcct 3059641 cccaaaaggg tcgtcacacc tgaagaaagc gcaacttcca tctgctgagg acaaataaaa 3059701 tgaatgtgcg tgtccactcc cccggctgtt aaaattttgc cttcaccgga aatcacctct 3059761 gtccccgctc cgatgaccat gtgcggatcg actccatcca tgatatcagg atttccgctt 3059821 tttccgacac cgacaatccg gccgtctttc acaccgacat ccgctttgac aatgcctgtg 3059881 taatccaata gcacgacgtt ggtgataacc aaatccaaag cgccgtcctt ccctgtgatt 3059941 ctgccgtttt ggcccatgcc gtctcggata gtttttccgc cgccaaagat catttcttca 3060001 ccgtatactg tgaaatcctt ttcgacttcg atccataaat ccgtgtcgcc caatctgatt 3060061 ttatcgcccg ttgtcgggcc aaacagttcc gcatattcct cccgtgacat tttcatcgga 3060121 ttacaccctc catccagccg gcttgtttta agttggccaa cgttttttct ttgccgcgtt 3060181 catcgataaa cgtgtcggcc attccgttca gccctctaat tgtcttgcgt cctctgattt 3060241 ccactagtga gaccgttttc tgctctcccg gctcaaaacg gaccgacgtg cctgatggaa 3060301 catcaagacg catgccgatc gccagctcac ggtcaaataa taaagccccg ttggcctccg 3060361 caaaatgaaa atgcgaaccg acttgaatgg agcgtgatcc ggtgtttttt accgttacct 3060421 cccgtatctc acggccttca ttaatcgtaa tggttccctc agcaatttga aatgctcccg 3060481 gcttcatgac ttcacctccg cagaaattgg ctgatgtacc gtaacaagct ttacaccatc 3060541 cggaaatgtg gcctccacct gaatgctgtc cagcatctca ggcacaccct ccatcacatc 3060601 tttttccgtt aatacatggc ggccggcttc catcagctct gctactccct tcccatcacg 3060661 tgcgccttcc ataataaagc aggtgatata agcagcagcc tcaggatagt tcagcagaac 3060721 gccccgcgcc tttcgctgtt tggctaattc ccccgctgca aaaatgagca atttctcttg 3060781 ttcaactggt gtcagtttca tctgtagtcc tccttctttt gtcatataaa gcagatgcgg 3060841 ctactacgaa tttgcggaac agtcaggcgg gacatcacct ccctttcttc gagaatgggg 3060901 gtcatacggt aagatgcctt tcaaagcggc atgccgtttc ttcatcagcc ttgccatggt 3060961 caacaaccgt tcccctgtcg atcacggaaa gatcagatta acgcgttttc cagactgcgc 3061021 tcgactaaga taacaaatgt ctttttttct ggaaatttct ataataactt gtctgactag 3061081 ttcgacaatt aaaatctgaa ttccttccaa ttgtttatta agtaaaatat ttttcagatt 3061141 taccatcagc gctctggtga ttgcaagctg ctgctgttga ccgccttttc gttttgaaca 3061201 aacgtttgat taaaacaaat agccccctct gtttagccgg agtcggccta atacagcgac 3061261 aatctgcccc gggcgaagct aaggctgtgc aaaaccatcg attgatcata accagacgtt 3061321 acattcctga tggcagcccg ttgttttgct ccgcaaccgg aagcatggca tggaggccag 3061381 tctgaggcgc cgacctccac gataccgaga acccgactat tgccattaac tccgcatcat 3061441 ggacggtcac ttcgctgatc gccaccgttc ctcttaatga gtgaagaatt ccggccttca 3061501 ctgaatcccc gcttgtgtcg atatcaactg ttttctcgca ctcccgtggc ttccgacact 3061561 ttcttcggtg cagtacattc cgtcatcaaa acccctttgt ttgatttctt caaatgatgt 3061621 tataaaagtt tacaacttat gtcatcatta tatagaagag gcctattaat tcaaagaata 3061681 tttaaaaaat ttagttacct tgaccaaatc agcttctttt tttgttatat ttattcacat 3061741 cagaaaaagc gaaaaaaaaa gacaagaaac atttcgtttc ctgcctcttc cgtacgatta 3061801 atctttatct gaaaatttat ccttggcttt cccgatatcc ttttggattt cgccttttgc 3061861 cttatctttt ttgccttcag cctgcatgtc cgttctgtca gccatatctc cgactttatc 3061921 cttcacttct cctttggctt tattgaagcc gcccttcatt ttgtctttta cactatcgtt 3061981 acccatgtta attctcccct ctcaattatg tgtgtacttg ttaacttccc gatctgagag 3062041 gcaataaaca ttctaatgtt atttatcgat ttcgtagcgc tctccgtaac ggagcacctt 3062101 gtatatcgcc agcccgtctg atgacttttt ctccgaatat cggaccggca gcagggcaaa 3062161 aaacacataa tacgtagaaa aatagacaaa ctgatagaaa aacacattcg gctttaatac 3062221 actgtgtata atcagcagat tgattgcaaa aatcgtgatg aggttaaaca agcagccccc 3062281 tgcatacacg agtgcatttg agaatcgatt gtcaattttc aactccccgt accggcaaaa 3062341 agaatcgata aaataaatcg ttctgaaccg tatgggtcca attttaagca gcgtttttcc 3062401 catgcctata tccaacgatc cctttccgcc aaaaataaaa gccataaagc tgtgccctga 3062461 aacatgtata atctgtacaa gcggcagaac aatgaggaaa gaccacagaa acttcaccat 3062521 atcattaaaa ccaaacattg aattccccct cacatgcata tctgcatccc aaaacggctt 3062581 ttgttcaaaa aacagtgctg tagcgatttt tcctgttctc cccggaaata aacgttccga 3062641 tgctcccctt tttttgcata aaaaaaaacc atctgccagc agatggtttt gtctcatact 3062701 tcatataaac aatcgttcct ttgaatcatc tctctcatgc tgaccgcttt ttcataaaaa 3062761 tacaccgctt ctttatattg ttcgcgatga ctgaaataag aggcagcatc taaagcaaat 3062821 tcttcaatat atacatacag gcccttttct tccatataat caaatacttc ttgaatcata 3062881 ttcaaattga cagattccac atataatgcc tgcagaaatt tatattttgc cagactgaag 3062941 aagtcgtttc gtttttgggc aatggcaatc cctttttcat agtaccgtat cgcggcttcg 3063001 ctatcttgtt ttttgaaaag aacgcgagtc aggctgaaga gcgcttttgg aagctgttcc 3063061 agctgataat cctcgaagac aggaagcgct ttttcaaagt attcggcggc ctgatccagc 3063121 tcccccttgt catcatagca attaccaata ttataaaggg ctgatccgat caaacggggc 3063181 tgtccttcca ataaagcaag gcgatacgcg tcatctaaat gttcaagcgc tttttcataa 3063241 tttctgtagt caatgtagtt tcctgatatg acgaaatggc attgaattct tctgactctg 3063301 taaaaatcgt gagccttata cgtctccagc gcctgtacgg catggttcat ggaaaagtgc 3063361 gtctgcttca taatataaaa gacttccgcc actttaaaat gaaattccgc tctttcaatt 3063421 tcatcttcta caaacgcaag catcttctca gctttccgat aaaaggatat agccgagatg 3063481 taattgttct gttcaaattc gtacattcct ctaaacaagt gaaaataata ctcagataat 3063541 ccggagatgc tgtcctgatt gctttccagc gttttgatca attcacgata ttgaagctga 3063601 gattcctcgt gcaggtcagg ctttacataa tccagcataa tttggtgccg gtagctgatc 3063661 agctgataat acaggagaag cagctgatcc tcttccatct gttcgatatc tagatcaatt 3063721 tcttctttca gttttacggc atcagccact tgaaatgcta aaatgtgctt ataccactta 3063781 ttgattttca ctcctacttg agatgacggg atctcgtacg cggccatgcc cctccaaccc 3063841 tttctatttt ctaattggtt atattttatc ataatgtatg gctttggaat taaattttct 3063901 tacaatgatt ccttctttat gcctatcctt atatatttcg gtttttctac gtattttttg 3063961 cactcggatt ctaataaaaa agcttaccgg acagtgccga taagcttttg acttcaaatt 3064021 aaccgccaat ataagacatt tccactttct ttttgccaga tgcttttgat agcgtacgat 3064081 cgactgaata ctgatcgatc cgatttttcc atactgtccc gatcatttct gatagttcgt 3064141 catcacttaa ttcctggcga accggagctc tgaggtcaaa tccgcttgaa gcgaataagc 3064201 aggtaaacag ctctcctctc gcagaaagac gggctctgtt gcaagatccg cagaatgcat 3064261 cagatacaga tgatatgacg ccaatttctc cggagccgtc caagtagcgg aatctggaag 3064321 ccacttcgcc tatataatta ggcgctatcg gctcaaccgg catgtgttta ttgatcaaat 3064381 ctatgatttc cgcctttgtc atgacgtctt tcttttccca ttggttggtg ttgcctacgt 3064441 ccataaattc aatgaatctc aggatatgcc ctttttcttt aaaataacgg gccataggca 3064501 gtatatcttt ttcattgacg cccttttgaa cgaccatatt gattttaaca ccgagccccg 3064561 cttgcttcgc cgcttcaatg ccttccagca ccttgctgac agaaacaccg cgcccgttta 3064621 tcttcttaaa acgctcgtct tctaaagaat caaggctgat cgtaaccctt ttcagcccag 3064681 cctccttgag cctcttagca taaacaggca gcagtgatcc gtttgtcgtc atcgcgatgt 3064741 cacgaatacc cggtatgcgg gccagttttt tgattaattc cggcatatcc tttctcatga 3064801 ggggctctcc gccggtcaag cggatttttt caacgccaaa tcttgtgaca aacaatgtcg 3064861 caagccgttc cagctcctca aatgaaagca gctcctcttt ctttaaaaaa ggataatccg 3064921 ggccgaataa ttcggcgggc atacagtacg tgcatcggaa gttgcagcgg tctgtaacag 3064981 aaatgcgaag gtctctcagc ggtctgtttc ttttatccaa catctgacgc gactctgtaa 3065041 tcatagctac agccccttcc tactccctga ttctctcagg gtgtgtatat acattaaatg 3065101 atccgtttct gacaaatcca atcgctgtga tattcaattc ttcagccatt tgaatcgcaa 3065161 gctccgtcgg ggccgatttg gaaatgacaa tcgacacgcc gattttggcc gcttttaaca 3065221 ggacctctga tgagattctg ccgctgaaca caatcagttt gtcgcgtacg gacatcccgt 3065281 ttagaaggca gtgtccgtat agtttatcaa gtgcgttgtg ccgaccgata tctgtgcgca 3065341 tcaacagaag cttctctgtg tcgcaaagcg ccgcattatg gacgcctccc gtatcctgaa 3065401 acgtcccgct cccttgctgc atgtctttca taagcgccag acatgcctca ggcgatatct 3065461 tgatttggct gacagccgtc ttggctgttt tgacatcctg ctgaaaataa aaatgacggc 3065521 cctttccgca gcatgagccg atcacccgtt tcgtataatc cttttgatcc aatgtctcag 3065581 ggtgaacgag gtcgacatat acaaaaccga gactttcatc tattgtaaac cttttaattt 3065641 ctttttgaaa tcgtataaca ccctctgatg cgagaaatcc gatgacaagc tcttcgatat 3065701 gctcaggcgt acaaacgagc gtcacaaatt cactgccatt cagtatcact gtcaaaggga 3065761 attccgtcac catccggtct tctactttgc ttatttcccc ttgttcatag cgccatacat 3065821 ccctgaccgc agttacttta tcgttcaatg tctcttcccc tccgcaatgt tcctgccttt 3065881 atattttttc acactcctcg gattttgtcg aattctgaga cacaaaaaga gccctctata 3065941 taaagggctt ttacaggatg tgatgacggc ggtgtttagg caggacgcct aagcatttag 3066001 ccgccgttcc ttttataaca cgtgagcacc aatgtgcatt gacaacgaac gcggggtttg 3066061 tcgacacgct gagacacctc tgtataaagg actctatgtt tgattatgct gattcttttt 3066121 cagaaccgta aacagcacaa tagctgcgat caaggtgaga atgctgacaa aaaagaaggc 3066181 tgccagtttt agaagaacac caagcaatat aaatgcaacg gtggctataa gaaaaatcat 3066241 tccgaataat ttcatatgtt caaccccttt ttagggtatc attcccgccc aaactgtttt 3066301 taaaccaata aaaaaggcgc ctgggggagc gcctgatctt taggttcctt actcagtaaa 3066361 tttttgtgct tctttttccc aagcctgttc gaactcatcc gcactgttcg ctgaaatata 3066421 ttctccgccg ccagcgacag ctgcttgttt catctcttca ttacccttga catcaaagtt 3066481 gaagccaatg atgtttacaa tcgtatccac atttgatgca cggagctttt cgatttccgc 3066541 cgcagggtct ccgccgcacg tttcttcacc gtcagtgatt aaatacacca cgtttttccc 3066601 gtctgcgtca aatgcttcaa attcttttct tgtgtctgca agtgctttgg caatcggtgt 3066661 ccatccagtc ggcttgagct cactcaatga attgtcaaac agagaccctt catatggatg 3066721 aaggccgtaa atggtttccg tcgtactgca cgaaagggct ttaccggaca gtttattgtt 3066781 ccctgcatgc ccgaaaacgc gaagcataag atttgtatcc tttggaagaa gttcggcaaa 3066841 agattttact gattttttgg caatgtctat tttgcgctct cctcctgttt tttgaaccat 3066901 gcttccgctt ccgtcaaaca aaacagctac atttgtatca gcctgtttct cagcggcaaa 3066961 agacggggag gcaatggaaa cagtcaacaa tccaatgata ccggcagcca gcaatttttt 3067021 catatgatta cttcctttct ttttcatatt ttccaactat atgttggatt cttctttatg 3067081 ctagaatacg aaaatgcaaa aagatatagg acatgctgcc ttttgtgctg ctttcacgat 3067141 ctgtccaaaa tcgcttgaaa tgccgttcat ttttagccat ttccgcccag aaagcataaa 3067201 cagcttgtgt gatcattcat tcttttttcg ccttgattat gacagaaaaa cggaaatctg 3067261 ctactatgct acaggcagac agctaattag ttttgaagtt tttgttacat acaaaaagag 3067321 gctgaccatc accagcctct tttttcttat ttagataaca ttagtgattg ctgagtgaaa 3067381 attttctcaa catctttttg ggtataagcc gggaagtatt caccgccgcc tactttcgca 3067441 attgcgttca gctggccttt gtatccctct ttataatcaa agccgatcac attaacagtg 3067501 atattgtctt tttgcagttc ctttgctgtt ttaatcgggt ttcctccgca cgtttcctca 3067561 ccgtctgtca acagatacac cactttttcc ccttttgcat caagctggtc aaaagaagat 3067621 ttcgcctcgt tcagcgcttt ggcaattggc gtccagccag tcggcccaat tgtattgaga 3067681 gaattgagga agctttgctc gttaaagctt tggaagccgt atacgttgcg aatggcttca 3067741 catgactgaa cttttccgga atttttattg tttccttcag agccaaacac gctcattttc 3067801 acctgagttc cttctggcaa tgagctcgca aactttgaaa tttctttttt ggctgaatta 3067861 aatttagata caccatctat tcttttcgcc atacttccgc tggcatcaag caagaccgcc 3067921 acgttcgccg gcgctttagc ctccgtttct gtcttttcag ctgcaaaagc aggtgaagtt 3067981 aatccaaaaa gcaatcctgt catcatgatc agtgaaaatc ttttcttcat gttcgtaccc 3068041 ctttaccaat ttgtttctgc gtgcagatgt tcaacgctga acataatcta tcgtaatcaa 3068101 caaaaaccga gaaataaata gggcgggctt ccccattgct gttgtttact tttgcataga 3068161 aacctatgtt tttattagtg atttccacct aacgccccta tgaaaagaga agattgtccg 3068221 cctttcggct ttcgttatat gagtctgtcg aagtctgtcg acaaatgtgg atgactttac 3068281 cacaatctca aagcctgaaa tcaggaaaaa aggactgatc cttaaagacg gtcagaagct 3068341 cctctaaacc gtttcagcta ctcttagata aaagatattc aggaacagaa aaagacgccc 3068401 aatgagcgtc tttttctact ttttcgccat atatttattc aaaaacgcat ctgcctcaga 3068461 aatttgtgtg ccttggtaat agtactttac aatgtcatca accgttttgc cttctttggc 3068521 cataaaattc gctccgtatt ggctcatccc cacaccgtgg ccaaatcctc tcgtcgtgac 3068581 tgtaattgtg tctccatttc gcttccattc aaaatcggcg gagttgagac ccaacttttc 3068641 acgtatgtct cttcctttca gcgtcttgcc gttaatgacg gcagttgcga cctggtggcc 3068701 cggtgtctcg ccggtaatct tccctactgc gctagatcca tccagcttga cgccaagctt 3068761 ttgctgaaat tctgccgctg taaaggtttt cgttgcctta tatttcggag actttttatc 3068821 ccatgggctt ttgacgcttt ttaaatatgg gatagcactt gtccaataag cttctgcatt 3068881 ctctgtgtag ccgttgcttg tggagaaaaa ggatgcttca atcggctggt tgttgtacgt 3068941 taagattttg ccttgcgtac tggctaccgc atctgtgatt ttcttcagtt ttgtctcata 3069001 gcttgtgccc cactgttttt tcagctccgc tttgctttta tacacctgga acatctgtgt 3069061 atcatccacc agtgagcctt taggagcttc taccgctgaa tttgacacca tcagtctgac 3069121 aataaatgtt ctggcggcaa gcgcctgggc tttcagcgct tcaggtttaa aggttgccgg 3069181 catttcggag gcgacgactc caatcacata ctcttcaagc ggaatgtttt ctacggattg 3069241 atttgcggtt cgatagacgg gaatagaaac aggtgatgct ttcaatgttt ctgctccttt 3069301 cgatgctggt ttcgtgctga ctgctgtctt ttctgattct acgctggccc ccgcttcctt 3069361 attatgctgg aatggtataa ccaagagtgt gggaaccaag agaatcaatg cacatagtac 3069421 ggatagtgtg attgcgaatt gtttcatatt cagctgcctc ctgctcggga ttcgactcta 3069481 gtctagtcta tgggcaggga caagctaata tgactctcgt tttggacaga aactttattt 3069541 gtcatttacg tattcttttt tgctattttg cgcataatga tgataataca caaaaaataa 3069601 aaaaccagta tgccagagtg acatactgat tttcaagtaa gtttatgcat ttaagtcaga 3069661 aacgacttct ttattctctt gctcagaagc agactcatca tttacacgtt cgatgtctgc 3069721 gcccagagcg gcaagcttct gatggaaatc aacgtaaccg cggtctaagt gcttcaattc 3069781 agtaacacgt gtgtgacctt cagccactaa ccccgcaaga atcagcgctg cacctgcacg 3069841 caaatcagtc gctgcaactt cagctccctg aagctgtaca ggaccgttaa tgatgacaga 3069901 acgtccttca atcttgatat caccattcat acggcggaat tcttccgcat gcataaaacg 3069961 gttttcaaaa acggtttctg taatcatgct tgtgccgctt gcacgaagca gaagcgccat 3070021 catttgtgac tgcatatcag tcgggaagcc cgggtgaggc attgttttga tgtcaatcgg 3070081 tttaagctct ttcgggccga tgacacgcag accttcacct tcatccttaa ttgttacacc 3070141 catctcttcc atttttgcaa ttaaagaggt gaggtgctca ggaaccgctc cttttactaa 3070201 tacgtttcct tcagtgattg cagcagcaac cataaatgtg cccgcttcaa tacggtcagg 3070261 aataatatgg tgttttacgc cgtgaagctt ttcgactcct tcaattttga tggtgccggt 3070321 gccagctccg cggatttttc cgcccatgcc gttgatatag tttgctaaat caacgatttc 3070381 gggttctttt gccacgtttt ccagcgttgt tgttccttca gctagagcgg ctgccataat 3070441 caggttctct gtagctccta cacttgggaa gtccagataa atttttgcgc cttgcagtcg 3070501 gccttttact tcagcttcaa tgaagccatt accgactttg atttctgcgc ccattgcttc 3070561 aaaacctttt aaatgctgat caatcggtct ggaaccaatt gcgcatccgc ccggaagtgc 3070621 aactcttgca tgacctgtac gcgcaagaag cggccccatg acaagcacag acgcacgcat 3070681 tttacgaaca tattcaaaag gtgcttcagt ttgcaaagcg tatgaagcat ttacagtcac 3070741 ttcattattt tcaaaatgca catctgctcc taaatgacgc aacacttcgt taattgtata 3070801 tacatcggag agcgtaggta catcacaaat tacgcttttt tcttcacttg ctaataaaga 3070861 tgcagcgata acaggtaaaa cggcattttt agcgccttca actttgactg tgccgtttaa 3070921 cttctgaccg ccgcggacga tgattttttc caaggtattc ccctccgcgt ccctaaattc 3070981 tctatattaa tattcagtcg taacgattgg tgtgccaacc gtaacggtat gttttccgcc 3071041 cattcctgca cttctaagtg caatttgcaa attcatttta tgtttcgagg tcataatgta 3071101 ctcttcccac tcatctgtaa acgcagaaat agaaacgaaa tttggctcaa ctacatgttc 3071161 tactgatctt gcttgaaatt catttaataa ctgatttgct tttttttgca aaacaatatt 3071221 catattatca tctaagtgac catttagaca agtaaaaata actacttttt cttggaatat 3071281 cccaagtgtc tcccgttcaa actgttcata tgtatcattc cagctatccg gtgtctctag 3071341 actcatttgc tcatataata aatacgaagt tggattgtgt tttttgaggg ttgtgacaag 3071401 ctgcagtcta aaagaagtac gatttttttt gtcagtatat gtgccaattg cctttatcat 3071461 tttatcttcc cgtgcaatca cccaatcata ttgacgatac tcttgtttta aacgttgcac 3071521 tttttgataa aattcttttt cggtcagtga caagttttgt tttgcatgca atgtccactt 3071581 atctattgac acatcttgac gttccatccc ctctgccatc tgtgctaacg gcgttaattc 3071641 actcgcatga atggtatgga aaacagcaat gacgaagctt aacatgacgg aaatgataat 3071701 agcgtggctt acttgttttt tcttcatgtt catctctccc ccttatcccc agttttaccg 3071761 gaggcaagag gcgccatacg taaaaatctt cgtcaaaact cgagctattc gcttcaaccc 3071821 gcttctccca accatttaat aatgttcaaa acctattaaa atagataggg aagctgctgt 3071881 gaataattga ggtaatctaa aaagaaattg gcaacggccg ttccaatggc gattgtcagc 3071941 aaaatcatca ggagtcttgc ctgcacgact ttgccttttt tgattaacgg atctatattg 3072001 acggcttgca acgcccacca agtcactgct ataaaaatca ggtgaacgac aatgccgatt 3072061 gcagcctgct gtcccaatac actcatctat tacactcctt tctctgcgtt catacccttt 3072121 cttattatat aagaagcaca gataaagatg atacatttta tacagaacgg aataatcagc 3072181 caaatctagg gctaatcccc gcttaaagtg cgattctttt acatggtata ctttattgga 3072241 aaggagctgg caaatgtgaa tcattctttt tttcagcctg aaaagcaata tggtgaggac 3072301 ctgccaattt ttgatcagga atgggaagca attgcattct attatgatta tagacagtca 3072361 cagattgaag aactgaatga attgtgtcag ttttttaaca tttctcttac ctatacgaga 3072421 gaaagccttg aagagcttga aaacctctat tttcaaagta tacaagaact tttgcttgct 3072481 gattggaatc ttcctattga agaattcgag aaaatgatca gtgtttatct tatagattgt 3072541 gtgattgccc gccatgaaga tgctgaatgg gttgtaaaac cttatcccta taaagacggc 3072601 gcttatacac ttggctttag aagacatcgc aaatcgtggc atacaatgaa tgcctgtgat 3072661 ggtttatacc tgcgtccaaa agaggatcgc ccgttgctgt cgctgtttga ttctcttgtg 3072721 cgttcataaa aaaatccttc tcataaagag aaggattttt tcttatttcc ctgctacatc 3072781 caatctgttc aaagcccgct gtaacgcaag ctcagcccga cgaatgtcag tatcatctga 3072841 ttgagaattc aaacgctcct gcgcccgctg gcgtgcagct tcagcgcgct ctttatcgat 3072901 gccttccgct gtctcggcag cctgggcaag gatggtgaca tgatcaggac ggacttctac 3072961 aaaaccgccg ctgacggcaa ccatttcagt ctgcccgtct tttttcagac ggacagcgcc 3073021 gattttaaga ggagccacgg ttggaatatg gcctggcaaa ataccgagat cgccgctttc 3073081 ggctctcaca ctcaccattt cgatatccgc atcgtatact gggccgtcgg gagtaacgat 3073141 attgacttta acggtcttca tgcttttacc ctcctaggac cagattaaac ttctacaccc 3073201 atttcttttg ctttctcaac aacttcttcg atacggccta caagacggaa tgcatcttct 3073261 ggaagatggt catatttacc ggctaagatt tctttgaagc cttgtaccgt ctcttttaca 3073321 ggcacgtaag aacctttttg tccagtgaac tgttcagcca cgtggaagtt ctgagaaagg 3073381 aagaactgga tacgacgtgc gcggtgaacg acaagtttgt cttcctcgcc taattcatcc 3073441 ataccgagaa tcgcaatgat atcctgaagc tctttgtaac gctgaagcgt tgactgtact 3073501 tcacgcgcaa ccgcatagtg ctcttctcca acaatttcag gagcaagggc gcgtgatgta 3073561 gatgccaacg gatcaaccgc agggtaaata cccatttcag ttaatttacg ctcaaggttt 3073621 gttgtcgcat ccaagtgagc gaacgttgtc gccggcgccg ggtcagtgta gtcatcggca 3073681 ggcacgtaga tcgcctggat agatgtaact gatccaacgt tcgtagacgt gatacgctct 3073741 tggagctgac ccatctcagt tgcaagcgtc ggctgataac caaccgctga aggcatacgg 3073801 ccaagaaggg ctgaaacctc tgaacccgct tgtgtgaaac ggaaaatgtt atcgatgaag 3073861 aacagtacgt cctgtccttg tacatcacgg aagtgctcag ccattgtaag gcctgtcaaa 3073921 gcaacacgca tacgtgcgcc cggcggctcg ttcatttgtc cgaataccat ggctgttttg 3073981 ttgattacgc cagagtcact catttcgtag aaaaggtcgt tcccttcacg agtacgctct 3074041 cctacgccgg cgaatacaga gataccgccg tgctcttgcg cgatgttgtt gattaattcc 3074101 tggattaata cggttttacc tacaccggca ccaccgaaca atccgatttt accgccctta 3074161 atgtaaggag caagcaaatc aacaacttta atacctgttt caagaatttc aacttctgtt 3074221 gaaagctgat cgaatgaagg cgcctgtctg tgaatcggat cctttttcgc atccgcagga 3074281 accggctcat tcaaatcaat attttctccg agaacgttaa atacacgtcc aagtgttaca 3074341 tcaccaaccg gtactgagat tggcgctcct gtatctacag cttccatacc gcgctgaaca 3074401 ccatctgtag atgccattgc gattgtacgg actgtatcat cacctaaatg aagagcgacc 3074461 tcaagcgtta aatcaatacc tacttcgttt tcacttgcag ctggctgtga aattttaatc 3074521 gcattataaa tttcaggcaa gtgaccgtct tcaaaacgca cgtcgacgac cggtcctaat 3074581 acctggctaa cgcgtccttt cttcatcgct atccctcctg acaaaatctt tctattctaa 3074641 agcggctgct ccgccgacaa tttccgtaat ttcttgtgtg atggctgctt ggcgagcgcg 3074701 gttgtaagaa agcgaaagtg aatcgataag ttccttcgcg ttgtctgtcg cgtttttcat 3074761 cgccgtcatt cttgcagcgt gctcacttgc tttactgtca agaagcgcac cgaagattaa 3074821 gctttctgca tattgaggaa gcaaaacctc cagaacctcc tcttcagatg gttcaaattc 3074881 ataagacgcc gttctttttc cgccgccgct gcccaaatca gataacggca gaagtttttt 3074941 ctccgttact tcttgagtaa tggcgctgac aaaatggtta taaacaaggt gcaattcatc 3075001 aaacgcaccg tctataaaca tttgaatcgt ttgacgggca agatctttaa tttctgtaaa 3075061 cgttacttca tctccaagtc ctgttaactc ggaaatgatc ggaatctccc gtttcttaaa 3075121 gaaatcacgg cccactcttc cgatggcaat caccgcatac tcatccttag actgatgacg 3075181 ttcttgcatg gcctgataag cactccgtaa aaccgaactg ttaaaagcgc cggcaagacc 3075241 gcggtcagac gtaatgacaa ggtatgccgt ttttttcact tctctgctga gaagcatcgg 3075301 gtgcttcacg ttgccggaaa ctcttccgac gtttgacaca acctcttgga ttttatccat 3075361 atatggcaca aatgattttg cattgttttc agcacgattc agcttagccg cagataccat 3075421 ctgcatggct tttgtaatct gacttgtttt tttcgttgac gtgatccttg acttaatatc 3075481 gcgtaatgag gccaaagatt tcaccacctt ttctcttcat ctgcgtaaaa agagagaaaa 3075541 agagaacctt tttctctcat cagcattcga gttagttgct tggtgcaaat gtgcgtttga 3075601 agccttcgat tgcagctttg aagtcttcat cagcaggaag gtttcctgtt ttcgcaattc 3075661 cgtcaagcag gtctttatgg ttttggtcaa ggtacatgta gtactcttct tcaaaacgtc 3075721 tgatatccgc cacaggaata tcatcgagat atccttttgt cagcgcataa agaatagcta 3075781 cttgcttttc aaccggaagc ggcttgttca gatcctgctt cagcacttca actgtacgcg 3075841 caccgcggtt cagttttgcc tgagtcgctt ggtcgaggtc agaaccgaat tgagcgaatg 3075901 cttccagctc acggtatgac gcaaggtcaa gacgcaaagt acctgatact tttttcatcg 3075961 ctttgatttg cgctgagccg ccgacacggg atacagacaa tccggcattg atcgctggac 3076021 gtacgcctga gaagaacaaa tcagattgca ggaagatctg tccgtcggtg atggaaatga 3076081 cgttcgtcgg aatataagca gagatatctc cggcttgtgt ttctacgaac ggcagagctg 3076141 taattgatcc tgcgcctttc gcgtcgctaa gctttgctgc acgctcaagc agacgggaat 3076201 gaagatagaa tacatcccca gggaacgctt cacggcctgg cggacggcga agaagcaagg 3076261 acagctcacg gtaagcggcc gcttgtttag aaagatcatc gtatacaaca agaacgtgct 3076321 tgccgttgta cataaattct tctgccattg taaccccagc atacggtgcc aggtacagaa 3076381 gcggtgccgg ctgtgacgca gacgccgtta caacaattgt ataatcaagc gcgccgtgtt 3076441 tacgcaatgt ttctactacg ccgcggactg ttgattcttt ttggccgatc gcaacatata 3076501 cacagatcat gtcttggtct ttttggttca ggatcgcatc gatcgcaaca gatgttttac 3076561 ctgtttgacg gtcaccgatg atcagctcac gctggccgcg gccgattgga atcagtgcat 3076621 cgatcgcttt gataccggtt tgaagcggtt catgaacgga tttacggtcc ataacgcctg 3076681 gtgcagggct ttcgatcgga cgagttttgc ttgtcagaat cgggcctagt ccgtcaaccg 3076741 gctggcctag cgggtttaca atacggccga ttaactcttc accaacagga acctccatga 3076801 tgcggcctgt tctttttact tcgtctccct cacggatctc actgaaaggt cctaagatga 3076861 cgatacctac gtttgattcc tcaaggtttt gagccatacc caaaacaccg tttgaaaatt 3076921 cgacaagttc accggccata cagttgtcaa ggccgtgcac acgtgcaata ccgtcaccga 3076981 cttggatgac tgtacctacg tcttgaactt caatatcaga ttgataattt tgtatttgct 3077041 gttttatcag cgtgctaatc tcttcagctt tgatgctcac ttaggtttca ccccttctat 3077101 cgattttccc cggctaattg acgttcaatg cgctgaagct tcccgcttac gctgccgtca 3077161 taaatccggt ttccaatgcg gactttaata ccgcctatta aatccgtctg cacttcattt 3077221 ctgattctca gtgaagcgac tccggctttt tttgcaaaca cttgtgataa tggtaacatt 3077281 tctgcatccg tcagcggttt cactgaatat acgattgcgt cttctgtttg acgggccaca 3077341 tttgcgagtt tgataaactc atctgtgagc tcagggacaa tcgcggcacg atggcggtca 3077401 atcaaaagaa aaatcgtatt gagtacggac tgtgacaaag agccaaatgc attttgaatc 3077461 agctcttttt tcttcgcagc cggcaccttc ggatggttca acacatcatt aagcgctttt 3077521 tcattttgaa atacttgttt tacaacaatt agctcttctt ctacttgatt cagctgagcg 3077581 gactcattgg ctatatcaaa aagagctgat gcatatcgtt tagagacagc tgatccactc 3077641 atcggctttc tcctacctct ttaagatagt cctggatcaa tttctcttgc gcttgttcat 3077701 ccagttcttt ttcgatcact ttcgacgcaa tcatgacaga aagagacgct acttgctcac 3077761 ggagagcaga aaccgcctgt tccttttcct tcacgatttc agttcttgct gcttctttca 3077821 gacgttcaga ttctgcacgt gcagcctgaa taatctcttc tttttgcttc tctcccagtt 3077881 tctttgcgtt ttcgataaga gtttgggatt cctgtcttgc ttcttttaaa agaacgcgct 3077941 gctcttcaat cagctgctgc gcttctttat ttttttcttc agcagacgta atttctccag 3078001 cgatgtggtc ttcacgctgt ttcattatgt ttaatagcgg ccctaaagcg tatttcttca 3078061 gaagcgctaa taagattaac atagctaaca gttggaacag gatatctccg ccgttaaacg 3078121 acaatcctag ttcaagtggt aattgagaca tctactacgg caactccctt ctgcaggttt 3078181 ttctttgctg atccagcagc cgcacttgtc tcttttcagc cggcaaggcg ggatgcttat 3078241 cagacataaa gcaatggcga aggttctctt ggaatgatct tcgccatttt tagttcatat 3078301 aaggctttta tgcttagcca aagaacgcta agaatgcgat aacgacagcg ataataggaa 3078361 gggcttcaac taatgcgata cccatgaaca taagagttct cagttcttta cctgcttccg 3078421 gctgacgggc aatcccctct accgtacgtg aaacaatcaa accgttacca atacctgcac 3078481 caagtgcgcc taaaccaatt gcaatcgcag ctgctattaa attcatgaaa aagttcctcc 3078541 tttaaaatgt tatccgtttg gatataatgt tttaatgatc atgactgatt ttatgagaca 3078601 tgtacaccat cgtcagcatt gtaaagataa atgcctggat agcaccaata aataaactga 3078661 atgcttgcca tgccagcatc ggcagaatgg caccgattgt accgacaaga ccgagagcca 3078721 cgctttgcga ataatggctt gttgctaatc ccgcaagcag gccgagaaga atctcaccgg 3078781 cgaagatgtt accatacagc cgcaaaccta gagtcagcgt attcgcaaac tcttcgatga 3078841 ttttcatcgg gagcatgaat ggaacaggtc ttaaatagtc tttggaatat tccttgagcc 3078901 ctttcatctt cacaccatag tagtgggtta aagcaacaac catcacggct agcgttaatg 3078961 taatggcagg atcggctgtc ggagacttcc accagagctc atgtccgatt gtaatagaga 3079021 acggcagccc cagcatattc gacacaaata tgtacatcag caatgtgaca ccaagtgcca 3079081 agaagttagc ccctgttttt aaatccattg tactgccaat aatattgcgg acgaaatcaa 3079141 caatccattc cataaagttc tgggcttttc cgggacggat cgaaagcgtt cttgtcgtca 3079201 atatagcaat caataaaaca atcacactcg ccacagtaat catcagaatg tttgtcagat 3079261 taaaagtaag acctagaaat tctatagttc tgtaaccatg attcaaaggg ttttcacctc 3079321 tcttccattg atgaacgttt aagctggata aaggaatcta tcataatgac agggtatatt 3079381 gtcattaatc caataactgt acttgccata tgaaagtatt cgggattttt ataggcaaca 3079441 gccacagcaa gaatcgcatt gcaccaccgc gctgcgctcc cgagagatcg tatggacttt 3079501 cctttctcta cagctctgtc aaaagcattc attcttctga cgagcagtaa aaaattaaac 3079561 aaactgaaaa cagttcccag aataaggcct aaaaaaacgg ttttatacgc tgttaaacca 3079621 taacccagta catacactgc caaaatgaac aataaatatt tgcgttgtct gctaaatgta 3079681 agcttgggat cgtccatcaa ttatctgtct cctgatgaaa aaataatgta tagcttggat 3079741 acggcaaaaa tcagcggtta acccttagta gaagaccttt tttgaccggc aaaacgggcc 3079801 tgttcgaaaa aatcattcat ccgcaagcct tgcagggatg ctgtttcatt cgcttaaata 3079861 aatcctcata atacgggttt gctgagagga tttacattga ggatgaggac tataatgaaa 3079921 gctatgaaaa ccttctcata ataccctcgt ttagcataca atagccccta acatgtgtca 3079981 atctgtttaa agttaaaaaa ctttttatac tttacgtctc cacagaatgt tcacattttc 3080041 acctataatt gtatacagat tcaccgaata gcaaaaaact ggataaaaaa atgaaacccc 3080101 cttttgggga tttcattttt tattttgttc caaacatgcg gtcacccgca tctccgagac 3080161 ctggaacaat atatcctttt tcatttaatt tttcatctag cgccgcaatg taaatatcaa 3080221 cgtccgaatg atgcttctgc aattcttcca caccctccgg cgctgctaca agacacatga 3080281 aacggatatt tttcgcaccg cgttttttaa ggctgtgaat ggcttcaact gcggaaccgc 3080341 ctgtagcgag catcgggtca accacgatga attcacgctc ttccacatca gaaggaagct 3080401 tgacatagta ttccacgggt tttaaggttt ctggatcacg gtaaaggccg acatgtccca 3080461 cttttgccgc aggaatcagc tttaaaatgc cgtcaaccat tcccaatcct gctctgagga 3080521 taggaaccac tccgagtttt ttccctgaga tgactttcga tttcgcagcc tgaaccggtg 3080581 tattgatatc cacttcttcc agaggaagat cgcgggtaat ttcaaatgcc atgagtgtag 3080641 ccacttcatc tactaactct ctaaaatcct tcgtacctgt attttcattc cgtatatatg 3080701 tcagcttgtg ctgaattaaa ggatgatcaa atacataaac ctttcccata ctgtgtttca 3080761 gctccttttt tattgtccca tcaacaatta cacacttcta ttgattctac aaaaaaagac 3080821 attgagtttc aagaacatcg tcaaaaaacc cgccgggcat aagcccaagc gggttttagg 3080881 atcttaataa tctaattctt tatataaagg aaatttatca gtcagagcag ctacacgctg 3080941 tcttgcttct tcaagttttc cttcatcttc gtggtttttc aatgcaagcg caatgatagc 3081001 accgacttct tctaatgcgt ctccgtcaaa accgcggctg gttacagcag ctgtaccaag 3081061 acggatgccg cttgttacga aaggtttttc aggatcatat ggaatcgcgt ttttgttaga 3081121 cgtaatacca atttcatcaa gtacatgctc cgcaacctta ccagtcagtc cgagcgaacg 3081181 aaggtcaaca aggataaggt ggttgtctgt tccgcctgaa acgagctgga tgccctcttt 3081241 cgttaaggct tcagccagac gtttcgcgtt tgaaatgacg ttttgtgcat atgttttgaa 3081301 atcgtcctgc aatacttcac cgaatgaaac agcttttgcg gcaataacgt gcatcagagg 3081361 gccgccttga attccaggga agatcgattt atcaattttc ttgccaaact cttcacggca 3081421 aaggatcata ccgccgcgag gaccgcgaag tgttttatgt gttgttgttg taacgaaatc 3081481 agcgtaagga accgggtttg gatgaaggcc tgccgcaaca agtcctgcga tatgtgccat 3081541 atccaccatg aagtaagcgc cgacttcatc agcaatttca cggaatttct taaagtcgat 3081601 tgtacgagga tacgcacttg ctcctgctac gataagcttc ggtttatgag cgagggcttt 3081661 ttcacgcacg tcatcgtaat caatatattg agtttcttta tctacgccgt actcaacaaa 3081721 gttatattga acaccgctga agttgactgg gcttccgtgt gttaaatggc cgccgtggga 3081781 gaggttcatc ccaagtacag tatcgccttg ctccaaaatc gtgaagtaca ctgccatgtt 3081841 tgcttgtgcg cctgaatgag gctgaacgtt tacatgctcc gctccaaaga tttccttcgc 3081901 gcggtcacgg gcgatatctt caacgacatc gacgtgctcg catccgccgt agtagcgttt 3081961 gcccggatat ccttctgcgt acttatttgt caaaacagat ccttgtgctt ccataaccgc 3082021 ttcacttaca aagttctcag aagcaatcaa ttcgatctta gtctgttggc gttcacgctc 3082081 atttttaatg gcgttaaaca cttgttcgtc ttgcgcaggt aaatgtttca tcagcgagat 3082141 cctctcctat ccgtatcctg ttctttgttt ttaccatcac tattgtacat ggtttttaag 3082201 gccgatgtaa aagattattt ttaaaaaatc taaattttta ttggtaaaaa cgaatattaa 3082261 taacttaaat ttaatttaaa gttcggaatt tatttcacta tcttaaaata aaagaaaaga 3082321 ctggctatgc agtcctttca ttcgcactca taaaccgccc gcactccgcc gattagtttc 3082381 ggccgtgtac gcgccaatgt cacatgagct gaaccgaggc tgttttgaga gacacgcaca 3082441 gggacagcca ccggtttcag atgcatgccg ataaacgtat cgcctatatc aattccggcg 3082501 tcagcctgaa tggtttcaac aagaacagga gacttcatct gcttaaacgc ataagacgcc 3082561 atcgctccgc ccgcttttgg aacgggcacg gcagaaacgg ttggaagcct gaacagcttg 3082621 gctgtttctg cttcgacgac aagcgctctg tttaaatgct cgcagcattg aaacgccaga 3082681 tggattcccg ttttttcccg gagctcagca agtccgctgt agatgctttc agcgatatct 3082741 acactgcccg atgtgccgat ccggctgccg gccacttcgc tcgtgctgca tccaaggacg 3082801 aagagctgat cttgtttcaa ttccgcttgg tcctgaaact cagacagcat cgtcttccac 3082861 gtttgtttca actcattcat taaacagcac ccctacaggt ttttctcttc ataatcggag 3082921 atttttccaa tacgcgtttg gtgtcttccc ccggtaaact cagtagtcag ccagattttt 3082981 gcgatttccc gagccaaacc aggtccgatc acccgttcac ccatcgcaag gatgtttgtg 3083041 tcattatgct ccctcgtcgc cttcgcgctg aaggtatcgt gcgccagcgc gcagcgaatc 3083101 ccttttactt tattagcgga aatgctcatg ccgatgcctg tcccgcaaat taaaatgcct 3083161 ctgtcaactt cgccgctaac cactttttcg gccaccggaa aagcataatc cggataatcg 3083221 acagagccgc tgccgcagtc acagcccata tcaatatatt caatttgcaa ttcgtccatt 3083281 aactctttga tttcatttcg aatgtgaacg ccgccatgat ccgatgcaat ggctactttc 3083341 atctgctttt cctcccagcg tgtgtgatgc ggcccgcccg ctttattgac cgcgcagcct 3083401 gtccgctctt tgattcacac catatgatgt gcttttcact atattctact ccttcacgca 3083461 ggatttgcaa atgacctgtt tgcagatttt ctgacaactt atctacggtc ttttttcagc 3083521 tgttttgcca gctgccgaag aagctcttca agctcatctc gcgtttgttt atagatgtca 3083581 attgagccgc cgaacggatc gaggacatca ccatggctgc ctgtgacata ttcttttaac 3083641 gtaaacactt tatcacgata acgtccaaat tggctggcaa tgatctgttt gtgctgatgg 3083701 gtcatagcca gaaccaaatc agccgattcc ataagttctt cagttaatgg agaagacaca 3083761 tgattaaggg caatgtgttt ttcaaacagc gcttcgactg catgaggcgt cgctttccca 3083821 ttaggtgaag caaacacgcc tgccgagcgg acattgacat tcagcccttc cctttctgca 3083881 attgatttaa aaagcgcctc agccattggg ctgcggcacg tatttccagt acagacaaaa 3083941 ataatatcca tgtcagtcac cccttatttt tctctattat atatgaagaa aaaagaaacg 3084001 gcgacttcgt ttcttttatt ggtatattaa attggcaaaa gcagctttaa tccaaacacg 3084061 attaatatga tgcccccgag cgcttcgctg tatgtgccaa gccatgactg cacttgtttt 3084121 ccgaccagca ggcccagcca tgtcaacatc atgctgaaca gcccgaacag ggtaattgtg 3084181 aggagcggat gcgagccgta tatccccaag ctcaagccga cggaaaagct gtcaaggctg 3084241 acgccgatgg caaacagcaa taagcccggc cctgccggtg acatgaatcg ttcttctgac 3084301 tgtttaaaag aggccataag catttgaacc ccaagaacaa aaagcagcgc cccaccgata 3084361 taaaccgcta acacgccgag gagccctgac agcatgttac cggccgccat ccctgcgaga 3084421 ggcatgatga cgtgaaagag gccgatgatg aaaccaatat agaatatctg cttctttcta 3084481 agtttgacca tgcccattcc aaggccgaca gaaaaagcat ccatccctaa agcaaacgcc 3084541 atgatgctta atgtaatcag ttcgcctata aacaaatccg acatacataa ataaccccct 3084601 tggacacgcc ccgctttttt agcctatgcg tgtccaaaaa gggttagaac atctgactgc 3084661 tttcagcgaa tcactcttcc tccggcggct ttcatcagcc tgttcataat agcaagaccg 3084721 acacctgtat ccggaaagga ttccgctata atgaaatcca ccttattctc atcaaagctg 3084781 cgcaaagcat catacagccc tgccgcaaca gtctcaagct gagcccgtct tccgcagctc 3084841 ttcacataat cagcggaata aacgcccgct ttttcttctg tcgtcaggac accgacccgt 3084901 cttccaccct gttgatattc ttgaatgagg tgctgaatgc gctctgggct gccttcgcaa 3084961 atggcaagag gcgctgtcgg cgcataatgt gtatatttca tccctggaga aatcggcttc 3085021 tcgttttggt cgctgagccc tttatccaca tggatcggcc cgatcaccgc ttcaatttgt 3085081 tccttcgtaa tgccgccagg acgcaagaga acagggatgt cgtccgcaca tgaaagcaca 3085141 gttgattcga ccccgattcc ggtagggcct ccatccacaa taccggctat gcggccatcc 3085201 aagtcgtgag ccacatgctc cgcttttgtg ggacttggct tgcctgatag attggcgctc 3085261 ggtgctgcaa tcggcagtcc cgattcgcga atcaatgcaa gggcaagcgg atgatccggc 3085321 attctaatgg caaccgtttc aagacctgcc gttacacgag gtgaaagcgc atcaggtttg 3085381 caaggcagaa tgagcgtaag tgctcccggc caaaaccgtt tcatcaatgt tttcgccttt 3085441 tccggcgccg ggcccgttaa atcctcaagc tggctgatat ccgcaatgtg gacaatcagg 3085501 ggattatcgc tcggccgccc tttcgcctca tatatttttt tgacggcatc cgtatttttt 3085561 gcgtttgcgc ctaggccata tactgtttct gtcggaaagg caacgacctc attttctcgg 3085621 agcaaagcgg ctgcttgtgc aatttgtgga tcatttgtgg ataactcgtc agttacatcc 3085681 acaaaccatc ttttcgtttt catttctgac caaactcctt attcacaaca ataaaacgat 3085741 tgttttacgc gtgtaatcct tttgaaagta taaaagatgt cctgtaataa aacaagcgtt 3085801 atccacaaat tgtggacaac gctaataaag aagtggataa gtatgtgtat aaactgcact 3085861 tatccagacg cttttttcat caaaacggct ccttctgttt gccgcgattc acagaagtga 3085921 tcagaagaaa acagctcctc cggtacactc tcagctcttt caaaacccat ggccgtcaga 3085981 aagtccgcag aggaatgctg atttgctact aggtacacgg ttttgatctg atgcttttcg 3086041 cacagcacct ccatgctttg aaaaagcgtg acgatgtggc cttggtgaag cttgtccgat 3086101 atgacaagtg atcgcagcag cccctggtca cagcttattt tttcaatacc gaggcatccg 3086161 gcaatgtttt tctcactgtc ctccagcata agaaattgag tgaagccttc tttcacgcct 3086221 tcatagctgg tttttgcctg ttttaaaaat gcctcgagca catctccgtc tttttccctt 3086281 gccacccgca gttgataaaa catccgttca ccccgttttt gcgttctttc ttccaatcta 3086341 tgaggcaaat ctatttttag accagatgat taggaaaaaa ggtcggaaat ccattcgact 3086401 aaaaagaatt tcacttctgt gccgtcttct ttttcttcgt tctcttcttt tttggctttt 3086461 tccgctttag cggttacgtc ctcaagcact ttttcagtct gcttttttga ggcttcttta 3086521 tcttcttgtt ctttgacggc ttccccgtta gaaaaatcaa gaaagcagag gggcgggaac 3086581 agcacacacc accagttggc gccgtctccg tttccaagcg taatcaaaat cgcttcatac 3086641 tcaccagcgg gatataccat gttgccgtaa agctttgtcg gaaacgagat tttgtcaaaa 3086701 tcaacggata tcgactgatt cgctccttct ttctccattg tttcctttgc aattgctttg 3086761 atttcaggca gctttgaacg aatcacgcga cgcgcttctt caatagaagt aatatccttt 3086821 acccaagttg tgatttcttt attcaccgcg tctcttatat gacgttttaa ttgctggtct 3086881 tgatcactat cgctgtttgc cagtattctc aaacgaatcg cctgatcagg tatgaccacc 3086941 ggctgatttt ccgatttttg tgccgtctct tcttttgcca gccctacgag cgctccggat 3087001 aataaaagaa agatatatat acaaatgatt actgtttttt tcatcggtcc ccaccgttcc 3087061 tctccgtgct ttgtttctag ccctattatg gacaaggaga gcctgggata aacgtgcagg 3087121 gtgaaaaaaa tctagcaagc tgttaatctt atttatggta cgatagtgtt ttaggaggtt 3087181 taagatgaaa tacaattata cagtgctgtt atcagcattc acgatgtccg ttctttattc 3087241 agtaatttat attcattcat ttatcattgc cgctctcatc acaatggcat tttattttct 3087301 gtttccttat ttgatcttcg cactgccgct tcaaatcatg atgaataaaa agccgaaacg 3087361 tttcagccct ttgtatctgc tgtattacct tgccgctgct tttattgcca acgcgatcat 3087421 tttcggcatg cttcagcctt cgggacaatc tctgtttcaa aatacagcct tttatctttt 3087481 cgctgtatta acagctctta tctattggat atgggattct gttttactgc aaaaaaagga 3087541 agcctaagag gcttcctttt ttattaaaac aaaatcgtca gtaaataaca tagaatggaa 3087601 ggtatcgccg caacaaagaa agcggccgcc attttcatgc gagatgtacg gccttctttg 3087661 gtttctgaat ggtagtttgc ccgctgatcg cttccgctta cagccaaacc cgatgtaatg 3087721 atcgcgagcc ccactaaaac gagagacgca acgccaaaaa tcgcttcata tgaaagagcc 3087781 tgcggaaaaa tggtgccaat catgctctca atcgcaatga gcaggattcc tgctgtcagg 3087841 gcctttttca tgtttacatc ccctttgctg gtgttaaaca gcttgatcca ttcactcgcc 3087901 agcaagctgc ttatttattt ttatgaatca gagcgcatat ggttctgtct tttccattaa 3087961 tatctttcag cacttccact tccgccccct taaacgcctt gaggatcagg tctttgaccg 3088021 ccgctccctg tttccagccg atttcaaaaa cgacaaatac tttatccttc ataacaagcg 3088081 gaatgtcttc cataaaccgc ttataaaatt tcagcccgtc tccgccatcg gtgagtgcgt 3088141 gcagcggctc atgaaaacgg acaatttccg ataaatcagc catttcttcc tctgaaatat 3088201 atggcgggtt tgagacaatg atatccgctt tttttcccgc cttaataaaa ggctcaagca 3088261 gatcgccctg ataaaagcgc acattcgctc cgagtttttc tgcattggca gaggcgactt 3088321 gcagcgcctc tttcgaaata tcgaccgccg acacagaaaa gctttggttt tcaagcgcaa 3088381 gcgtgacggc tattgcgccg ctccctgtac caacgtcaac aacttcgagc ttgccgtctt 3088441 cagaaaaaac actccgatat ttttcaagca aatgaaagac aacttcttca gtttccggcc 3088501 gcgggatcag cacatcatca ttcaccataa attcccgtcc ataaaaaaac tcttttccta 3088561 taatgtattg aaccggcacg ccctctttat gcatctcaac gtgacgctta aagcgataca 3088621 gttcgtcttc accaatcggt tcctgtaagc ttgcgagcag cttgcttctc tccattccgg 3088681 tatcataaag caataggagc tcggccgcat tttcttctct tcccgcttcg gttaaataag 3088741 aagaagccca tttcagggct tcgaatatcg tcttcatctt aaccttccga ctgctgaagc 3088801 ttgcttgcct gatcttcaac aatcagcgct tcaaccactt cgtcaagttt tccttcaaga 3088861 atctgatcaa gcttttgaat cgtcaaaccg attctgtgat ccgtcacacg gttttgcggg 3088921 aagttgtatg tgcggatacg ttcagagcgg tcaccagatc cgactgctga tttccgtgtt 3088981 tgatcatatt cagcctgggc ttcctgctga aatttatcat agattctggc acggagaacc 3089041 ttcattgctt tttctttgtt cttaatttga gatttttcat cctggcatga tacaacaaca 3089101 cctgtcggca agtgagtcag acgaaccgca gacattgttg tgttaacgct ttgtccgccc 3089161 ggtccgcttg aagcaaatgt atcgacacgg atatccttct catggatgtc gacctctacc 3089221 tcttctgcct caggaagaca tgccactgtt gcagtggatg tatggatgcg tccgcctgat 3089281 tctgtttccg gaacacgctg tacgcggtgg gcgccgtttt catatttgag tttagaatac 3089341 gcgccgcttc ctgtaatcat aaagatgatc tctttgtagc cgcccgttcc ggttacattc 3089401 gcttccatga cctctgtttt ccagccctga agctcagcat aacgggaata cattctgtac 3089461 agattgcccg cgaataaagc ggcttcctcg cctcccgcag ccccgcggat ctccatgata 3089521 acgtttttgt cgtcattagg atctttcggg atcaggagca ccttcagccg ttctgacagt 3089581 gtttccgttt ccttctgaag ttcagaaatc tcttccttca ccatgtcgcg catctcagca 3089641 tccagcttct cttcaagcat cgcttttgca tcagccagct gttctgacgc atctctgtat 3089701 tgtctatata cgtcaactgt ttcttgtata tcagattgct cttttgaata ttctcttagc 3089761 tttttcggat cgttgactac ttctggatcg ctcaaaagct catttaattt ctcgtatcgt 3089821 tcttcaattg attttaaacg gtctaacacg gtcttcacct ctgttttcct gtgcgtaaca 3089881 ttctcattat agtatagtga ttaaccccag tcaaaagcat ttcaatccca gctggaaaag 3089941 ctccctctgc tatactggaa ttcgaggagg gatgatgttg ctgaaatcca tacatcatat 3090001 tgcaatcata tgttcagatt acgaaaagtc gaaagctttc tacgtacata agcttggttt 3090061 tcaggtgatt caagaaacgt accgcgaaga gcgcggctcc tataagcttg atttgtcgct 3090121 taacggctcg tatgtcattg agctgttctc gtttcccgat ccgcccgaac gacaaacccg 3090181 gcctgaagcc gcaggcctgc gccacctcgc ctttacagtc ggcagcttgg ataaagctgt 3090241 tcaagagctt catgaaaaag gaatcgaaac agagccaatc agaacagatc cgctgaccgg 3090301 caagcgtttc accttctttt ttgatcctga ccagcttcca ttagaactgt atgaacaata 3090361 acagtttttg aagaaaaaaa ggagataccc actttctttg ccgaatcttt tcttgttttg 3090421 tctaacggga agggaaccgc attctatggt cgaataccta gcttaaaagg aggtatggga 3090481 tcatgaatac aaatatggta gcaagtgaac tcggcgtctc cgcaaagacg gtgcagcggt 3090541 gggtgaagca gctgaatctt ccggccgaac gcaatgagct cggacactat tcgttcacgg 3090601 cagaagacgt gaaggttcta aaatccgttc aaaaacaaat ctctgaaggc acggcgattc 3090661 aggatattca tctgccgaaa agcgctaaaa agcgcacagg cttccttgtc caaaaaacaa 3090721 gtagcgacac agaacgaaga atcgagcagc ttgaacaaaa gctggacacc cttttacagc 3090781 aaaggcagga cgaaagcgaa ttgatggcaa ggatgtcgga actggaacgc cagctgaaac 3090841 aaaaagccga tgaaggtgta tcttaccagc tgcttcagca ccgcagagaa atcgatgata 3090901 ttcttgcaga tctgcaatca ctgacctcac aaatgaaaga attcaccgct cattcgatcc 3090961 ccgagactgc tgctgcttct gaaaaaacca aaacaagaaa aaaaccgctg ctgtcactgt 3091021 tcaaatttca aacctaaagc aaaaagctcc cttaaaggga gctttttttg ttacgcagta 3091081 agcgcgataa tgattggaag tgaaatcaat gacagaatcg cactgaccac aaacgcagtt 3091141 gcagtttctt cttcttgttt ctcgaaacga gtcgcaatca tggctgcaac ggcagaacca 3091201 gggaatgcaa caagaaggat tgcttttgtt gtttggtcag ctggaagtcc gatagcaaga 3091261 gcaatcagga acattaacgc aggctgaacc gcaactttta gtaacgcaat accgatagcc 3091321 ggcatactga gtttaatttt acgaatacca acggtaacac caacagcgaa gagagcaaca 3091381 ccagatgttg tgcttccaag ctgatcaagc attttaacac ccagctcagg aagagtgaaa 3091441 ttgaaaacca gcaccaagat catactgatt aacggagcag ctgcaagcgg ctcacaaaga 3091501 ccatgcagga ttgattttcc tgtcatcttc cagaagctgt cgccactctc ttcgtttttc 3091561 ttagaagact caccaacagt agcgataatg atcgcgagcg gatcaagaat cgcgttaacc 3091621 acgatacctg tgaccgcgat cggaatcgca acttcattcg ctccgaataa gcttcccaat 3091681 accgggatac ccataaatgc gaatgtcggc tgtgcagagt tcaaagaaaa tacagatgag 3091741 ttcgttaaat catacttgaa tataaatctg caaaccaaaa gaatgatgat atagaaacca 3091801 acaatcccaa taattaaaga aatcattaaa ggtacttgtg ataaaaattc acttctggaa 3091861 gttgtcaaaa taccagcgat aaagtgagct ggaagtgcgt atttcgttac taacgtactt 3091921 accccttttg ccgacttggc atcataactt ccaaaatgtc ctgcaaacca acccagcacg 3091981 ataacaaaga agatcggcgc caggaggatt aagatatcta agatgctcaa aatattctcc 3092041 tccaaatcct atgtccgtat actttagctt tacaaaaagc tttccctcgg acagaaaaat 3092101 ttactcgcta attatttcgc gatgactttt ttgtattcag gtgtccacat tgcatcaagt 3092161 accgcttgtt tcacatcttc aggctgacga tttgccacgc cgtctttaat tgctgcttca 3092221 gcaacggcaa tcgcaacttg gatagaaacc tcttgaagct tatcaatgct tggaagcaat 3092281 cctgctccag gtgtttcaag atcaaccatt tcagcaatcg catcagcagt tgcagcaaac 3092341 atagcaggtg taatgatacg cgcttcagct acaattgaac caagtccaag accagggaac 3092401 gcgaatgcgt tgttagattg tccgatttca taagaaacac cgttgtattc tacattgtca 3092461 aatgggcttc ctgttgcaat aagcactttt ccgtcagtcc atttgaacag atcttcagga 3092521 acagcttcag caaggtgagt cgggttagac atcggcatga taaccggacg gtctacgtga 3092581 gatgccattt cttttacaat ttcctctgtg aatgcacctg aaacccctga agtaccaatc 3092641 aagattgttg gtttcgcttg acgaacaact tcatcgaatg gaatttgacc tttttcatcg 3092701 cgcttccagt ctttcacttc atccgcattg cgaaggtaag gtttttggaa atcaaggatg 3092761 ccttcgatgt cttcagtcag caagcctctg taatcaagtg tgtagaaacg tttgttagct 3092821 tcttcttcag ataatccggc tagcaccatt gtgtcacgga tttggtcagc aataccgata 3092881 ccagcagaac cagcaccgaa gataacaaca cgctgatctt taatagaagc gccggttttc 3092941 ttcatagcgg caagcacacc tgcaagtgta atcgcgccag taccttgaat atcatcatta 3093001 aatgtcagga tttcatgatt gtattttttc atgatgttgc gtgcattttt gttgccaagg 3093061 tcttcccagt gaagaagcgc tttagggaag aatttcaatg cagcttttac ataagcgtca 3093121 atgaaagctt cgtagcgttc accttgaaca cgttcatgct tgttaccaat atataaagga 3093181 tcgtttagaa gtttttcgtt gttcgtaccg acatcaagca caaccgggat aacacggcta 3093241 gggtcaatac cagctgcagc agtgtagaca gccaatttac cgattgcaat attaataccg 3093301 cctacacccc agtcaccgat accgagaatg ctttcggagt cagtagcaac gataagatca 3093361 atatcgcctg ctgtcgcatg aaggttttca aacgcttttt caataccgtc aatgttatcg 3093421 attgacaagt agattccttg aggtcttcta tattcatggc tgtattcctg aatcgcttca 3093481 ccaactgttg gcgtgtacac aacaggaagc atttcgcgaa gatggttttt cagcaattta 3093541 tagaaaagaa cttcgttacg gtttgcaaga tcacttaagt aaacattttg acgaaggcgg 3093601 tcaggctgcg cttggaattg ctcgtacgcg cgttgtgctt gttgatcaag agaaagtaca 3093661 gttggcggca gaagcccttc taagccgagt tcttgtcttt cttctagtga aaaagcaacg 3093721 cctttattta aagtaggaat agataaaact tcttttcctc taagagttgt ttctaagtgg 3093781 ccttctttcg ttttttttat gttattcaag caaatctcct tctttcttga aatagttaac 3093841 caagttaagt aataacccat ctaaaatatg accgatcatg atctttatgc gactttgtga 3093901 caattattcg aacaatgtct caaaactatt tacattacgt aagctattgt atgcctgtca 3093961 aaatcaaaat tcaagagaag aaaattactt aattttttaa tatacttatt taaatttttt 3094021 aattgaatat tatcagaata taaaaaaaac accggtgttt ttagccggtg cattctatct 3094081 ttatacccat gttttggact attttttaga tttacctggg acttcgtgat gatgtctgca 3094141 tcttgcttca tatgattcag ctgcaccaac caaaatgacc ggatcatcgt aagaagcagg 3094201 tttgccgtca atgaggcgct gtgttctgct cgccggtgat ccgcaaacag aacagacggc 3094261 ttgcagcttt gtcacacttt ccgcaatcgc catgatattc gggacgacac cgaacggctc 3094321 tcccctaaaa tccatatcaa ggcctgctgc tatcacacgg tagcctttat cggcaagaga 3094381 tgataaaacc tcaacaattt cctgatcaaa aaactgcact tcatcaaccg caaccacatc 3094441 tgtactttca ctgatgtgat cccaaatgtc cgcagcagac gaaatggcat agctcgtcat 3094501 cgatgttcca ttatgggaga caacagcagc ttcgctgtat cggttatcaa ttacaggctt 3094561 aaataccctg acttcctgct tggcataagt tgctctcttc actcttctga tcagctcttc 3094621 agatttcccc gagaacatgc tgccgcaaat cagctcaagc cacccgcttt gtttcattat 3094681 gtacataggc ttcgctcccc tctctctgcc agctgtgttt tagacaatat aaaaaacagg 3094741 caagactgct gcttgcctgt tgagaaatct attattactt aagaccgtat tttttgttaa 3094801 agcgatcaac acgaccatca gcagaagcga atttttgacg gccagtgtag aatgggtggc 3094861 attcagagca aatctcaacg cgtacctctt cttttactga gcctgtttca aattcatttc 3094921 cgcaagcgca tttaactgtt gcttttttga aattaggatg aattcctgct ttcattgtat 3094981 ccatctcctt ccgccctgaa tcccgtgtgg aaacagagtt attatttcgg agcattgtcc 3095041 gaaacgcata tgagaaaatt atatcagtga tttacttctt ttgcaaatac aatttacctt 3095101 cttgcagatg atagatttgc ctgtttccat tcttgattga gaatatcgaa aaattcctgg 3095161 tttgttttgg tttttttcat ttttctcatg aacttttctg cgaaatcagg tgaatcagac 3095221 atcgttttgc ggatagacca taaacgatca agatgctctt taggcacaag cagctcttct 3095281 ttgcgcgttc ctgaacggcg gatatcgatg gcagggaaga tgcggcgctc ggcaagagag 3095341 cggtcaagat ggagctccat gttgcctgtt cccttgaatt cttcataaat gacatcatcc 3095401 atacgtgaac ctgtatcgac cagagccgta gcaaggatgg ttaagctgcc gccctcttcg 3095461 atatttctcg cagccccaaa gaagcgtttc ggacggtgga acgccgctgg gtcaatcccc 3095521 ccggaaagcg ttcttccact tggcggaatc actaagttgt aggcgcgggc aagacgtgtg 3095581 atgctgtcca tcaggataat gacgtctttt ttgtgttcca cgagacgcat cgcacgttca 3095641 agcacaagct cggccacttt gatatggttt tccggcactt catcaaacgt tgagctgacg 3095701 acatccccag ctacagagcg ctcgatatcg gttacttcct caggtctttc gtcaattaaa 3095761 agcacgatca gctctgcttc aggctggttc gctgtaatgc tgttggcaat ttccttcagc 3095821 aacatcgttt ttccggcttt cggcggcgca acaatcaatc cgcgctgccc aaatccaacc 3095881 ggcgccatca tgtccataat tcttgtagac aagaagttcg gctttgtttc aagcaccatt 3095941 tgacgatccg gataaagtgg cgtaagagcc gggaaatgca cacgctcttt tgcagattcg 3096001 ggatcatccc catttactgc ttcaacgtgc aaaagtccat agtaacgctc attttctttt 3096061 ggcgggcgaa ccttgccaga tactttgtct ccgttccgca aatcgaaacg gcggatttgt 3096121 gaagctgaga tgtaaatgtc ttctgagctt ggagagtagt tgatcggtct caggaatccg 3096181 aaaccttcag actggatgat ctcgagaacg ccttccataa acagcagatc ttcctgttct 3096241 gcattcgctt tcagaatggc gaaaatgagt tctttttttg tcagtttgct gtaataggag 3096301 attttataat gtcttgcaag ttcataaagc tctttcaatt tcatattttc caaagaggaa 3096361 atagatacgt ctttcataaa aacaccacgc ttttcatagt caatatctta ctctgaacat 3096421 gtcatctgct gcttttgcac aacatccgcc aaagcacatt ctttttttaa cataaaggaa 3096481 cttctatcgg taacacttcc acccatgatc ggcgcttttg ttaaaaggat tgtcttaatg 3096541 agttttgaag gaagcgagga caaaaacatg agaagatcaa tacttatatc gtctgtatgc 3096601 ggtagaaatt gaaactttcc tagtgcttaa aagaaggtat tacgcagtaa aattcgcagc 3096661 actctttatt tttaccttat ttcaaaaaat tattcaactg aaataaggtt ttgacacgga 3096721 attgatagag ttgacgcttt tctgcaaaag ttaaagcggg ctcacacccg ctttttctgt 3096781 ttgttatgga cggattacaa gatttggttt ctttttcaag ctgtgtctgc cgtcaacgaa 3096841 acgaacagtg cccgattttg cacggataac taagctttca gttgtaccga cagagccttt 3096901 gaattgaact ccttttaaca gctcgccgtc agtaacccct gtagctgcaa aaatcgcgtc 3096961 atcacccttc acaaggtctt ccatgcgaag cactttgctt aaatcaaggc ccattttgtg 3097021 acagcgagtg atttcttctt cgctttgcgg aagaagttta ccaatgattt ctccgccgag 3097081 tgcttttagc gcaacagcgg aaagcacacc ctcaggagcg ccgcctgatc cgaacaggat 3097141 atcaacgccc gtgtggtcga aagccgtgtt gatggcgcct gcgacatcgc cgtcattgat 3097201 caatttgatt ctggcgccgg cctcacgaag ctcggaaatg atttttgcgt gtctttcacg 3097261 gtttaaaatt gtggcaacga cgtcctcaac gtccttgttt ttcgcttttg ccaccgcttt 3097321 aaggttgtca atgacaggtg cttcgatgtc aatgcagccc accgcttccg gaccgactgc 3097381 gattttttgc atatacatgt caggagcatt cagaagcgtg ccatggtctg cgaccgcgat 3097441 aaccgtcagc gcgttccagc cgccgcttgc taagatgttt gtgccttcaa gagggtcaac 3097501 tgcgacatca acgcgagggc cgtacccgtt tccgagtttt tccccgatat acagcattgg 3097561 cgcttcgtcc atttcccctt caccgattac aacggtccct ttcatcggca ctgtatcaaa 3097621 aacgtctctc attgcacttg ttgccgcttc atcagcctca tctttttttc cccggcccat 3097681 ccatcttgct gatgccaatg ccgcagcttc tgtcacacgt accaattcca ttgataaact 3097741 tctttccatt tcaacacgat ctcctctcac aagaaaccat tatgaatttt gaagctgttc 3097801 tatttcttcg tcagtcattc tttcacgcca aattgtcgct ccaagcccct caagcttctt 3097861 ctcaaggctg ctgtatcctc ggtcaatatg ctccagtccc gtaatttccg tgacgccatc 3097921 agccatcagt ccggctacca ccaagcaggc tccggcacgc agatcactcg ccttcacttt 3097981 tgcgccttga agctcgacag gacctgtgat gatggcagat ctgccttcta ctttcatatt 3098041 ggcacccatt cgtctcagct catcaatgtg cttgaatctt gccgagtaga tggtgtctgt 3098101 gacgacactc gtccctttcg cccttgtcag gagcgccgtc atcggctgct gtaaatcagt 3098161 cggaaacccc gggtatacga gggttttgac gtcaaccggc tttaagttct tctgcccgcc 3098221 gacaatgagg agctggtcgt cgcttgtttc gatatgatag cccatttctc tcagctttgc 3098281 cgttaacgac tcaagatgag tagggatgac gttatcgata atgacttcct tgcccattgc 3098341 agcccctgca atcataaatg tcccggcttc aattctgtcc ggaatgatcg tatgcttgca 3098401 gccgtgcagt tccttcacgc cgtcgattcg aatcacattg gtgcccgcac ctttgatttt 3098461 ggcgcccatg ctggtaagca atgtcgcgac gtcaatgatc tcaggctcct tggcagcgtt 3098521 ttcgatgatc gttttccctt ctgccaaaac agcggcgagc ataatgttaa tcgttgcccc 3098581 aacgcttacg acatctaaat aaatccgtgc gcctctcagc ctttcagctc gcaaataaat 3098641 ggcgccttgt tcattggtta cttcagctcc gagtgcttca aagcctttga tatgctgatc 3098701 aatcggacgg ggccctaagt gacagccgcc aggcaatcca atgaccgcct gcttgaagcg 3098761 gccgagcatc gcccccatta aataatatga cgcgcgaagc ttttttactt tcccgttagg 3098821 aagcggcatg ctgatcatcg acgtagggtc aacaaccatt tccccattct caaaatgcac 3098881 gttgccgccg atttccttta acaggtcacg cagcgtttca atatctgaaa tctctggaag 3098941 cccttcaatt gtcacctcgg aatttgccaa aatggttgca ggtattaacg caacagcgct 3099001 gtttttagcg ccgctgatat gtactgtacc gtttaacgag tcaccgccgg caatattcaa 3099061 cttttccatg atagtctcct tccataagaa gatagctgcg gagctaaata aaatgtcatt 3099121 ttattctgtc tctgcaaata aagctcatgt ccaaaatcta gccaattcga agagaaagaa 3099181 tacaacacat tgtaaaatat caggaagaaa atagcgaagc tttggggggt acaggtttca 3099241 aaagatgcac agagacccgc cggctcgaga gacatcgtcg tcatccggca aaagcagtac 3099301 gcataccctt cattccgata tcagcttctg cagcccaatg attccttctc tgtaaagcgg 3099361 cgtcagcatc tgaagatccg ctgtatcagg tcggtgaaat acaaaggccg cggcaaacag 3099421 gcataaagct gtttgccgcc cctttcatta tttgttccag tctgccagga attgttcgat 3099481 tcctttgtct gttaacgggt gtttagtgag cgcatgaatg actttcagcg gcattgtgcc 3099541 gatatgagcc cctctaagag cagcttctgt cacgtgctgc ggatggcgga ttgacgctgc 3099601 aatgatttgc gtgtcaaggc cgtgaatgtc aaaaatctgt ttaacttctg aaatcaggtc 3099661 aagcccgttg tggccgatgt catctaaacg tcccaggaat ggagatacat atgttgcccc 3099721 cgctctggca gcaagaagcg cctggttggc attgaagatc aatgtaacgt ttgttttgat 3099781 gcctaagtca gtaagtgctc ttaccgcttt taaaccgtca gacgtcattg ggattttcac 3099841 cgtaatgttc ggagcgatct tcgccagttc ttttccttcc tcgatcattt cctcagcttt 3099901 caaagaaata acctctgcgc ttacagaccc tttcacgacg tctgtgatct cgcgaagacg 3099961 gtcgtggaat gatacgttag cttcctttgc tactaaacta ggattcgtcg ttacaccggc 3100021 gagaattcct aattcattcg cttctctaat ttcatcgata ttggctgtat caacaaagaa 3100081 taacattttc aaaaagcctc cctgattaag aaattttctg aactgcgaat atgattgcgc 3100141 tttctaaaga tagacggaaa accgcctgtc aagctgtcag gcggctataa aaagttccaa 3100201 ttgaattaag cttggtttga agaaccaaat tcacgcattt taccgataac tgtttctttg 3100261 atcgcttcac gagctggtcc aaggtattta cgtggatcgt actcgtcagg cttagctgcc 3100321 aatgtttcgc gaacagcttt tgcagaagaa atttggtttt cagtattcac gttgatttta 3100381 gctgtaccaa gtgaaattga ttttttgatg tcagcagtcg gaattccagt accgccgtga 3100441 agaactagcg gaaggccagt tgattttccg atctcttcca tttctttgaa gccaaggttt 3100501 ggctcacctt tgtaagggcc gtgaacagaa cctaatgcag gtgcaaggca gtcgatgcca 3100561 gtgcgctcaa caagctcttg gcactcttta ggatcagcgt agattacgcc ttcagcgata 3100621 acgtcatctt cttgtccgcc tactgttcca agctcagctt ctacagatac tccgtggaaa 3100681 tgagcaagct caacaacttt agcagttgtt gctacgtttt cttcaaatgg atggtgagaa 3100741 gcgtcgatca ttacagatgt gaaacctgca tgaatcgctt tcgcacaaga ttcaaagctt 3100801 gaaccgtggt ctaagtgaat cgcaacagga actgtcactt tgtactcttc cataagtgct 3100861 tttaccatag caacgactgt tttgaagccg cccatgtagc gtcccgcacc ttcggaaaca 3100921 ccaaggatca ctggagattt ttcttcttca gctgcttgta aaatcgcttg agtaaactca 3100981 aggttgttta agttaaattg tcctacagcg tacccttttt ctttagctgt attcaacatt 3101041 tccgtcatag aaactaaagg catgtcgaat gtcctcctta tgtagcctga ttgtcttcta 3101101 gcgaaaaaag ctttccaccc tagcatgacc catatattgc tgtcatatgt aaatactcag 3101161 atcgcttttt ctccataact aggataccaa cttttcgaca aatcggcaac ataatgacat 3101221 gattcatttg tttcttcttt ttgtcagtta gacttcaggg gcagatattt tttgacggcg 3101281 tctctgattt cgtcgatgtc aaacggcttg gcaaagtgcg tcagagcgcc caattccttc 3101341 gattcctgga tcatgtcgag ctctccgtat gccgtcatga taatgacccg gatgttttcg 3101401 tcaatgacct tcatccgttt taagatttcg attccgtcca tgccgggaat tttcatgtcc 3101461 aacagcacaa ggtcgggccg ttcttttgtc acaatgtcaa gcgcctgcag gccgttcgca 3101521 gcctgaaacg tctggtagcc ttctttattg aacacttcat ttagcaaaat acgaatgccg 3101581 tattgatcat caacgattaa aattttttca ttcatcattt tacaccccaa tattatgatt 3101641 ttcgtcaaaa gtaagcagta ttgtatgtat tctgtttgat tttcctattt cctttaatta 3101701 taatagtcta ctttacgaca ttttctgagc attttctctt ttgttgtata ctgatattgt 3101761 acgttataaa ggaggattca cttatgttga aaatattcac gacgcagtta acaggtattt 3101821 tttcccgcat tcaggataag gaatctgacg cgattgaaga tggggcgcgg ctgcttgctc 3101881 aagcggtgat cagcgggcat tccatttatt tatacggagc gaatgagctt cagggcgtct 3101941 tttatgaggc caccgaaagc aaagaaccct tcccatctgt caaagccttt ccagaaaacg 3102001 ctgaggaagt gacagaaagc gacagggtgc tgatgttttg ctcagggacg ggcacagccg 3102061 aagaacagga gctcgcaaaa gagctttatg aaaaaggtgc gggagtcgta tgcgtatcgc 3102121 ccgcagccaa agacagtgcg ggaatagaac agtattgtga tgtgcatatt gattctaaat 3102181 taaaaatgcc gcttgttccc gatgaagacg gcacccgtta cgggtttccc tctttaatga 3102241 cagcactgta tgtctatcac gctttatcgt ttacactaaa agaaattctg caagagtatg 3102301 cataatatct tattgtacat gctggaactt gccggaaaca aataaaaaag acttgcccgc 3102361 ttttgacaaa cggcaagtct tttttattac ttctgatttg cagcttcgac agacgctccg 3102421 ataaagcctt tgaatagagg ctgaggtctt gtcggtcttg acttgaactc tgggtggaac 3102481 tgagaagcca cgaaccaagg gtggtctttc agctcgatga tttcaacaag gcgtccatca 3102541 gggcttgtgc ctgagaatac gaagccttgc tcttccattt gctgtctgaa ttcattgtta 3102601 aactcatagc ggtggcggtg gcgctcgtac accacttcat cctgatacac ttcaaaggct 3102661 ttcgtgcctt cttcaagctt acaagggtaa aggccgagac gaagcgttcc cccaagatcc 3102721 tcaacatcct tttgttcagg aagaagatca atgatcgggt attgagttga cggatcaatt 3102781 tccgctgagt gagcgccttt taagcccaat acgtttcgtg cgtattcaat agacgccacc 3102841 tgcatgccca agcaaatgcc caagaacgga atgttgtttt cgcgcgcgta ttttgtcgcg 3102901 acgattttcc cttcaacacc gcggtctccg aatccgcccg gcacaatgat gccgtctgtt 3102961 ccgcttgtga gttctgcgat attgttttct gtcacttctt ccgcgttgat ccacttcact 3103021 tttacatctg tgtcaaacgc atagcccgca tggcggagag actcgacaac agaaatgtat 3103081 gcgtcaggaa gctcaacgta tttgccgaca aggccgattg taatcgtttg agacaggttg 3103141 ctgactttgt taacaagctc tttccactcg gacatttccg cttctttgca tgccaatttc 3103201 atgtgctcgc aaacaagctt atcaagccct tgtttttgaa gctccagcgg aatggagtaa 3103261 aggttgtccg catcttcaca ttcaataacc gcttttgtat cgatgtcgca gaaaagcgcg 3103321 attttatctt tcatatcttg agaaatcggc atttctgtac gaacgacgat gatgtttggc 3103381 tgaatgccca agctgcgcaa ttcttttacg ctgtgctgtg tcggttttgt ttttaattcg 3103441 ccagcagctt taatgtaagg cacgagcgta cagtggatgt acattacgtt ttcacggccg 3103501 atgtcgctct tcatttggcg gatcgcttca aggaatggca gtgattcgat gtctccgaca 3103561 gtaccgccga tttctgtaat gacaacatct gcgtttgtct ctttccctgc gcggtaaaca 3103621 cggtctttca attcgtttgt gatgtgcgga atgacctgta cggttcctcc aaggtaatct 3103681 ccgcggcgtt cttttttaag aactgttgaa tagattttac ctgttgtcac gttgctgaat 3103741 ttattcaggt taatgtcgat aaaacgctca tagtgaccaa ggtccaagtc tgtttcagcg 3103801 ccgtcatccg ttacgaatac ttcaccgtgc tggtacgggc tcattgttcc cgggtcaacg 3103861 ttgatgtatg gatcgaattt ttgaatcgtc acgttcagtc cgcggttttt cagcaaacgc 3103921 cctaatgaag ctgctacaat accctttcca agtgaggata caactccccc ggttacaaaa 3103981 atatatttcg tcatttcgtt tgctcctctc ttcgctctta gctacatttt taaaatgtac 3104041 tattttataa aaaatcattt agccttttaa atgatttata agaaaaatga ggggtgaaaa 3104101 taagaaagct ccctttcaat ttcttgaaag ggagcataac gtactatgtt ctctcttcgt 3104161 ttttgaagag cccaaaatac atactacata gttcgactat gaaagtcaag atcgttttga 3104221 agatgaaatc tgatactatt taatttcctc ttcttcatca tcatagtctt catcatcttc 3104281 atcaataata tcttcttcga tctcaagatc atcgtcgtct tcatcaagat cttcttcgtc 3104341 aaaatcgtcg gcttcaagat cgagttcttc ctcaacttca tccaaatcaa ggtcgtcttc 3104401 gtcgatctct tcaaactcgt caagatcaag atcttcttcg actgctttct tcgctttttt 3104461 ctttttcgcc ttgactgtcg gctgagtttc ttcatcaagc tgatcataag gataccagct 3104521 gcgaagcccc cacgtctggt cagaaagcgc caggaagcgg ccgtcaatgt ttaaatctgt 3104581 ataaaattga gcaatgcggt ctccaagctc ttcttttttc acgccgagca aagatgcgat 3104641 ttcatttaaa agctcctgaa aaggaactgg ttttttatgt tcttcaaata attcgtgagc 3104701 gatttcaact aaagccattt cctttagctc ttcctgtgaa tattgtttga tacccaaggt 3104761 cggacactcc ctttctatta cttatatgta tctgttttat caataatgaa agcgattttg 3104821 tatcgttctt atacaaacca tacctctcat tataaacaaa ataaaacaga atatgctacc 3104881 cttaacagcg ttaatttaaa taattttaca agagtgatcc gactgagaga tgttttccgt 3104941 taatccgcga gcattctgga gatgaccagt ctttgaattt cttgagtgcc ttcatagatt 3105001 tgcgtgattt ttgcatcacg catatagcgt tctaccggat aatcttttgt atagccgtag 3105061 ccgccgaaaa tctgcacggc ttcggtcgtt accttcatcg ccgtatcccc agccatcagt 3105121 ttggacatgg cggaagcttt tccatatgga aggcccgatg attctaacca tgcagcctga 3105181 taggtcagta gccttgaagc ttctatcatt gtcgccatat ccgcgagttt aaaagcgatg 3105241 ccctgctgct cggcgatcga ttttccgaat tgctttcgct cttttgcata ttgaagcgcc 3105301 gcatcaagcg ctccttgggc gatgcctaca gcttgtgcag ctatgccgtt tctgcctccg 3105361 tcaagcgtct tcatcgcgat tttgaagcct tctccttctt ctccgagacg ctttgatgcg 3105421 ggcactacac aatcttcgaa catgatttcc gttgtcggtg aagaacggat gcccagcttc 3105481 ttttctttct tgcctgtaaa aaatccttca aaatcctttt ctactataaa agcggtaacg 3105541 ccttttttct ttttctcggg atcggtgacg gcaaaaacaa tgtaaatatc agcaacgccg 3105601 ccgtttgtga taaacacttt ggaaccattt aacacatagt catcgccgat tcgttcagca 3105661 gttgttttca tgctgccggc gtcagagcca gaccctgctt cggtcaaagc gaatgcgccg 3105721 attttctctc cgagagccag ctgtgttaag tactctgtct tctgttcctc tgtcccaaag 3105781 gcaaacagcg gccagctgca aagagagata tgggcggaaa gcgtcacacc ggtggaggcg 3105841 cacacttttg acagctcttc caccgcgatg acgtaggcta aatagtcact tccaattccg 3105901 ccgtaatctt caggccatgg aattcccgtc aggcccagat ttgccatttc ccgaaacagc 3105961 tcgcgatcga agcgttcttg ttcgtcccgt tcagccgctg tcggggccac ctcatgcttc 3106021 gcaaaatcgc gcaccaattt tcgtatcatc tcatgttctt ctgataatga aaaattcatt 3106081 gcttctcccc cattttcaga tcagcgccta aaacggattg agccagaagc tcgacgacgt 3106141 cgtacgtttt gacttggtct tcggcttcct tcgcctttgt gccgtcccca agcatcgtga 3106201 gacaatacgg acagccagaa ctgatcaccg atgggttgac tgcgagcgct tgctctgtcc 3106261 tggcgacgtt aatcctgttg cctgtttctt cctccatcca cattaatccc ccgccggctc 3106321 cgcagcacat gccggtttcc cggcttctct ccatttcaac aagctgcacg cccggaatgg 3106381 ctttcaaaat ctctctcggc ggatcataga cttcattgta ccggcccaaa tagcacgaat 3106441 catggaaggt aatcgtctca tgaagcgggt gctgcggtct taattttccg tttttcacaa 3106501 gctcggccag cacttctgta tgatgataaa cctcgccttc aaatccgaaa tccggatatt 3106561 cgtttttaaa taaattgtat gcatggggat cgatcgtaac gatttttttg acatcatttt 3106621 tttcaaattc agaaatattc ttctcagcca gctcttggaa caaaaattca tttccgaggc 3106681 ggcgcggcgt gtctcctgaa tttttttctt tattgccgag aatcgcgaag gacacgcccg 3106741 cgtgattgag cagcttggca aaggaaattg cgattttctg gcttctgttg tcgtaagacc 3106801 ccatggagcc tacccagaaa aggtactcaa attcttttcc ttcttttttc atttctttta 3106861 cagtcggaat ctcagcatcc ggcgcctcgt cacgccaatt ttcacgttcc ttgcggttga 3106921 gtccccacgg attcccttgc cgctcaatac ttgtcattgc gcgctgggcg tcactgtcca 3106981 tttttccttc tgtcagtacg aggtagcggc ggaggtcgat gattttatcc acgtgctcat 3107041 tcatgaccgg gcattgatcc tcacagttcc ggcaagtggt gcatgcccaa atttcttcct 3107101 ctgtgatgac gtcgccgatc aagcttggat tgtaatcaag cgccgctgcg gcttcctgcg 3107161 atccgctgcc cgctgacgcc gcagccagct gattgcctct cgtatgccga aacgctgctg 3107221 cgggcaccca tggggagcgc gaggtgacgg cagcgccttt ttccgtgaga tggtctctga 3107281 gacgcaaaat caagtccatc ggagaaagca tttttccggt gcctgttgca ggacacatat 3107341 tggtacagcg gccgcactcg acacacgcgt atagatcaag cagctgagac tgtctgaaat 3107401 cctcaatttt tcccgctccg tagctttctt tcgtttcgtc ggtaaaatca attttttcaa 3107461 gttttccggc agattccatt cgattgaaaa agacgtttgc cgggccggcg attaaatggg 3107521 catgctttga ctgaggcacg tacactaaaa agctaagcaa gaataggaga tggatccacc 3107581 atgcgatata gaaaatcacc gccgcgcctg ttttcccgac accgctaagc ataaacgcaa 3107641 tacctgaggc aattggctcg ctccaagaaa gcccatgctc atgccaaatc agattcatcc 3107701 cgttcccaag cagaacggtc agcattaatc ctccgataaa aatgagaacg agtccggctt 3107761 tgaaaccgcg tttcagcctc acgagctttt cgatataacg tctgtagaat gcccacccaa 3107821 cagcaattaa aatgagaaac gtaacaattt cctgaaaaaa ggtgaaggcg ggatagaccg 3107881 ggccaagcga cagattccgg ccgggagcca gtcctttgat gataaagtca attgctccga 3107941 actgaaccaa tataaatccg tagaaaaaca tgacgtgaat gattccgctt ttcttgtcct 3108001 tgagcagttt tttctgtccg aatacattca cccatatggc gtgaagccgt tccttgaacc 3108061 gttgatcaaa ttgttctttc tggccgagct tgatgtaggc cagtctcgtt ttgaccaagt 3108121 aaacaaacaa atagacagcg taagcggtta caatcagaaa taataatgca tttgcgatga 3108181 gaaagccgct cattccaatt cccccttttt actgataaag accgcgatcc cctacccccg 3108241 aatctgtata agattatctt tatgataaat aatgaatgag tgttcagtca ataattaaat 3108301 tcctgctgtt cgggcacact acctttacta cggaaaggag tgccggtatg aaggtattta 3108361 tcgtgattat gatcattgtc gttattttct ttgccttgat tctgcttgat atcttcatgg 3108421 gccgtgccgg atacagaaaa aaggcgtacg agcctgtttt ttcaaaaaag aagagtgaca 3108481 tcgaattgat ccactgcggc gctgatctcg ttgagcggat gatgaatgat attcgccagg 3108541 ccgcctcttc tgttcacatg atgtttttta ttatgaaaaa tgatgaggtc agccacaata 3108601 tgtatacctt gctgaaaaca aaagcccaag ctggcgtatc cgtttatttg cttctggatt 3108661 gggcgggctg ccgggcaatt aaaaaaacgg cgcttcagac gatgaaaaat gccggcgtcc 3108721 atgtccatgt gatgaatcgt ccccgttttc cttttttctt ttttcacatg caaaaacgga 3108781 atcaccggaa gattacggtg atagacggaa aaatcggtta tatcggcggg tttaatatcg 3108841 ccgaagaata tcttggaaag aaggcgaagt tcggcaattg ggaggattat catctgcgca 3108901 tgatcggaga aggcgtacat gatcttcaaa cgctttttgc ttctgatcta aaacgaaata 3108961 ccggaatcga actgggttcg gatgtttggc caaagcttca gcaagggact atttctcaca 3109021 agatctatgc gaccgacggt tattcccttg aaaacatata cttggccaac attgcccaag 3109081 cgaagaatcg ccttacggtt tgcacgcctt attacattcc atcaaaaccg cttcaagagg 3109141 cccttattaa cgcaagaaaa aacggcgtat ccgtgagaat cattgtaccg atgaaatcag 3109201 accatccgct ggtacgagaa gcggctttta cgtattattc ggagctcttg gatgccggct 3109261 gtcttattta tcgttattat caagggtttt atcatgtaaa agccctcatc atagacgacc 3109321 atctcagcat tatcggaaca gccaacttcg ataaacggag cctgttctta aatgaagagg 3109381 tgaatgttga aattgatgac gaagcgttta caagtgaagt ctatgccaca attgaggagg 3109441 atatgaaaaa gtcggagctg ctgacgatgg aggatttcag caagcgcaca ttcaggcagc 3109501 gcccggcgga atggctcggc agggcattat cttatttctt ataaaggaga gttcctatga 3109561 ttttcagatt cgggttcgtt tcaaatgcga tgagcctttg ggatgcgtct cccgctaaaa 3109621 cattgacatt cgcgcgttat tcaaagcttt caaagactga aagaaaagaa gcgcttctga 3109681 ctgtgacaaa agccaatttg cgcaatacga tgagaaccct tcactatatc atcggccacg 3109741 gcattccttt gtaccgtttt tccagttcga ttgtgccgct ggctacgcat cccgacgtga 3109801 tgtgggattt tgtaacaccg tttcaaaaag agtttcggga gattggagag cttgttaaaa 3109861 cccatcaact gcgaacaagc tttcatccaa atcaattcac tctgtttacg agcccgaagg 3109921 aatccgtcac aaaaaatgcg gtaacagata tggcgtatca ctaccgcatg cttgaggcca 3109981 tgggcattgc tgatcgctcc gttatcaaca ttcatattgg cggcgcttac ggaaataaag 3110041 acaccgccac tgcacaattt catcaaaata taaaacagct gccgcaggag atcaaagagc 3110101 ggatgacact tgaaaatgat gataaaacat atacaacgga agaaacgctt caggtctgtg 3110161 agcaggagga tgttccgttt gtctttgact ttcatcattt ttacgccaat ccagacgatc 3110221 acgccgacct gaatgtagca ctgccccgca tgatcaaaac gtgggagcgg atcggccttc 3110281 agccaaaggt tcacttgtct tccccaaaat cggagcaagc gatacgcagc cacgccgatt 3110341 atgttgacgc caactttttg ctgccactgt tggaacgctt taggcaatgg ggaactaata 3110401 ttgatttcat gattgaagca aagcagaaag acaaggcgct tctccgcttg atggatgaat 3110461 taagctccat ccgcggtgtc aaacgcatcg ggggcggtgc gctgcaatgg aagtcataaa 3110521 tgtgcaaaaa taggtttacg acttgtcagc tttgggaact taggctatat aagacaacaa 3110581 tcgatggagg agaaagatca tgaaaaatat caagtctctg aaagtagccg cacaggcctt 3110641 tactttaaga aatttgattc atctttataa aatgtgccat tccggaagcc acgaggttta 3110701 tatttattca aagaaaacga tgtgcaaaat caaaagctta attgagcttg aaacgttccg 3110761 catggctcat aatgaaaagg aatatctgat cgtagttgaa ggaacaaaag catcacagct 3110821 cattgaaaaa ttccaaaatc tcatcgagcc tgctgagaga gaagcgctct aacttacata 3110881 caaaaaagga tagacatctg tctatccttt ttcttatgct cttacataat ggagctgaac 3110941 cgcttgtcca aattgttttg tcccttttaa ccgcagtttt gtttcatttg ttagttcgtg 3111001 aaacagcggg atgccgcttc ctaaaacgac gggaataaca gtgatgatga attcgtcgat 3111061 ggcatcttct ttcataaagt cattcacaag ctctgccccg ccagctatcc agatgtttga 3111121 gcctttttcc tgtttcaaac gggcagtgaa ggctctggct ccctcattga taaacgtcac 3111181 atgttcatct tgataactgt cgggcgatcc tgtaaaaaca tagcaggttt tatcctgata 3111241 cgggaaaacc ggtgttagca ctttaacgtg ctcatatgtg ctccgcccta aaatgactgt 3111301 atcaacagtc tgataaaaat cactgtagcc gttgtcacct tcaccttcaa attcatccag 3111361 ccaatcgatg cttccatctt cttttgcgat catcccgtcc aatgaaacag caatgtacag 3111421 cacagttttt ctttccatgt tctcctccta tcgatgcacc atttgcccga attgcgcttg 3111481 atgcagcctg ctgtataggc ctccggcttc gatcaggtct tgatgacggc cttgttcttc 3111541 aataccgttg tttgtgacga ctacaattct gtccgcgtct ttgattgttg ccagcctgtg 3111601 ggcgatgaca agcgtcgtgc gcccctcaga caactcttga agcgcctttt ggatcgccgc 3111661 ttccgtctct gtatcaaggg ctgaggtggc ttcgtcgaga atcaagatcg acggattttt 3111721 caagaacatc cttgcaattg acagacgctg tttttgcccg ccggaaagct tcacgccgcg 3111781 ttcgccaatc atagtatcca acccatcggg catgttatgg acgagctctt ccagatgcgc 3111841 ctgcttcaca gcttgccaaa tgtcttcttc tgatgcgcct agtcggccgt aggcgatatt 3111901 ttctctaagc gtgcccgaga ataagaaaac gtcctgctgc acgacgccaa tctgcccgcg 3111961 caacgaagaa agcgtcatgt cttttatact gatgccgtca atcgtaatgt cgccctccga 3112021 tgcttcataa aaacgcggaa gcagactgca aagcgttgat ttcccagcac ctgacggacc 3112081 gacgaacgcc accgtttccc ccgcttgaat ggataggttg atgtcattga ggacattgtg 3112141 atggtcatca tagccaaacg aaacatgttt atagcggata ttgcccttca ggccggaaac 3112201 atctttcgaa tcaggtgagt cctgaatatc cggctctgtc tccatgagct ccatatagct 3112261 tttgaaaccc gcgatccccc tcggatacat ttcgataatg gcattaattt tgtcaatagg 3112321 cctgaacagc acattcgtca agagtacaaa cgccacaaat tccccgtacg ataaggagcc 3112381 gcgaatgaca aaccacgtcc cgcacaaaag gacaaacagc gtgacaaacc gggtcagcat 3112441 atagctgatt gaaccgtttt tcgccatgat tttgtaggaa gaaagctttg tgacacgaaa 3112501 acgctggttg ttgacggcga agcgttcttt ttcaaatgct tcatttccga acgcctgcac 3112561 aagccggatg ccgccgatgt tattttctac acgcgcgctg aagtctccga tatccttgtt 3112621 cagcgtggta aatgctttgg tcattttttt gttgaaataa agcgctagcc aaatgacgat 3112681 cggcataatg ataaacgtta ataaagcaag ctgccagtta ataaacagca tcactccgaa 3112741 cgccccgaga atggtcatga ccgcaatgaa taagtcttcc ggtccgtgat gggcgacttc 3112801 accgatatac attaaatcgt tcgtgagctt cgacatcagc gttcccgtct tgttgttgtc 3112861 gtaaaatttg aacgagagct tttgcaaatg gtcaaaaagc gactttctca tatcagtctc 3112921 aatattgata ccaagcatgt gtccccagta ggtcacgata tactgaagag ccgagctgag 3112981 cgcgtacacc gcaaataacc cgattgaggt cgcgatgatc agtccccagt ccctgcccgg 3113041 cagcaaggta tcaataaaat aattgacgat caaaggaaaa ctcagctcca ttaaacctcc 3113101 cgcgatcgct gagaaaaagt cgagaaagaa caacgtttta tatggtttat aatatgaaaa 3113161 aaattgccgc agcaccctat cttcccccaa tgtataaata actgataata tttctcaatt 3113221 atactataca cgggctgttt tgtaagatca gatttctttt ttcttacaga acacctgaaa 3113281 acaggcgggc aaacgactct tttgtccggt cagccacacc tcttttataa aagccgacag 3113341 ggctgagctt ttcactttcc tgcatatcct cttcaaaatg ggcctcaagg gttcggatcg 3113401 cttcggcatc cgtgaagaac acattcactt caaagttgag ctgaaagctg cgcatgtcca 3113461 tattcgcggt accgacggag gcgagatcgc catcaatgat catgactttt tgatgcatga 3113521 agcctttttg gtaggagtac acttcaatgc cctcaaggag cagctccggg aaataggacc 3113581 tcgacgcgta ttgggtcaaa aagctgtcgt tcttctccgg caccataacc cttacctcta 3113641 ccccctttgt cgccgctgct tttagcgccg tgcgaatgga ttcattgggg acaaaatagg 3113701 gcgtggcgat ccatattgat ttctgcgctg aagaaatcat ttcataataa aggtcgctca 3113761 tgctttcctt catgtcaggg cctgtcgcga caatttgata aatgcctcct ccttccacgg 3113821 gaaccggggt attgtactcc tcttgatcaa ttagcacttc attggagaca tattcccaat 3113881 ccagcataaa gatagcgtgg agcgtttgca caatttcccc ctcaagccgc aggtgtgtat 3113941 ctctccaaaa tccgatgtac ggatctctgc tgatatattc cttcccgaca tttaatccac 3114001 ccacaaaacc ggttttccca tcgatgatca cgattttccg gtgatttctg aaattcagct 3114061 tctggttgaa aaacccgtat ttcagcggag aaaacgggac gatgtccacc cccgcttgtt 3114121 tcattctcat aatatctctt cttgccagct tcatgcttcc tgccgcatcg tataaaaacc 3114181 tcacctcgac accctggcgc gctttctcca tcataatatc catcatgccg cgtccgagca 3114241 tgtctgattt aaacatgtag tattcaatat gtatgtaaga ttccgctttt ctcattgctt 3114301 tgaaaatgtc cgggaaggtt tcttcgccgt ttttcagcac tttgatgttg cttttcgtat 3114361 tgatattcat atgggcagcc ctgatggaat atgtaaagaa cctctcttga ttgtccttca 3114421 gccctgtcac ttcgggcgtt tcctccttgt caaacagctt cctgagcttt tccctgttgt 3114481 acattcgttt tgtcttaaac agctttccct ttacataaag ctgtcccgaa aacagataaa 3114541 acacgtagcc gacgattgga aaaaagacaa gaatatggat ccatagcagc gtgtgctgcg 3114601 aggtgcggtt ttcaagaatt aatgaataga tgctgaacaa aataatgctt atatagcaaa 3114661 gcaatcctcc gtaaaactca agtctggaaa ccggaaaaaa ccaaatgaca tatgccccga 3114721 tgagcatcat atataaaaag aaaaattcca gtctcctttt cagcatcctg attctctcca 3114781 atctgattca attacctctg tattacctct tttttctaat cgataaacct tgtaagtaaa 3114841 aaacctctcc gccaaaggag gagaggttta gagaaaacta actgtcacgg aattcatccg 3114901 catcgtttct gcagaaataa agcaagacta ttggcaacgc cgagtgacaa catgagcggc 3114961 aagctgaacc cgctcagcac tccggcaagc gccgaaaaga aggcggcgct gtgactgcaa 3115021 atacggtgga tagagtaaat ttgataccca ttctgatgag agaaaatata taaaacggga 3115081 aattgatcag aaagatataa ggagttagtc aggctgaatc ataatctggc tgttccgccg 3115141 gtttaaaatg agtaaaatcc ttgatgttat ttccatatac aaacataaca ggattcccgg 3115201 cagcccagcc attaccttgg cagaaaaaac cccctcttgc aagggggatt ttcacgagcg 3115261 tttccgatat acaacgtagc tgcgggtcag atacttgagc ggcagactga acacatgaac 3115321 caatctcgta aacggccaca ggataaaaac gacgtatcct atcacaatat gaaacttaaa 3115381 ccatagcggg acactctcca tcaaagaggc gtcaggcctg aacaaaacga tttccctgaa 3115441 ccagggcccg actgtggtcc ggtaatcaaa tcctttcgaa tcaatgttga gaaacgtggc 3115501 cgcaacgcct gacagcatca tgaacagcag caggaggagc gtaaggatat cggatggcga 3115561 gctcgttttg cggattcttt tgtcaaacag ccttctgtac gtcaggatga caagtccggt 3115621 acatgccgca atgcccgccg gcaagccagc gccaatcgcc attttgtgat acatatgctc 3115681 tgaaatgcca agggaagcat acacgccttc tgggatcaga atccccatga catgcccgcc 3115741 gacaacgcac agcagtcccc agtgaaaaag tgtgctgcca gccgcaagtt ttttcttttc 3115801 taacagctcg cttgatttcg ccgtccagcc aaattggtca tgctgatagc ggtaaatatg 3115861 gccgccgata aagattgtca atacaatgta tggcataata ccccagagga tctgcccgct 3115921 catgcctgaa cagccccttc aacgctttca cgtacgccaa tgttttcaag cgcggccagc 3115981 agcacgtgca gcagttcagc gtatatactg tcattttttt cgagacggga tgccagctcc 3116041 ctcacattgg acagatattt ctcaaacacg cttctcgctg cttcaatttc tgcagccgca 3116101 gcaaattcca gcatcagcgg cagataatca ggcagctctt tctctgtcgg caggaaaccg 3116161 gattgctcgt atgtgttttt taaatgcagc aattcaatgc cgcgttccct ttgctcgcct 3116221 gagttaaagt aggtgacata catatttgtt tttttcccga agtcgaatgt atagacatag 3116281 tgttcaatca gcgcttccgg agaatagctg gctgacgtct cgaaaaagtg cagcagcttc 3116341 tcccggattt gccggttgcc gatttcttgg ataagagcct tccaatcggg aagctcggct 3116401 ctccactctt catccggata agagagaaga caggaaagag cagagaacgt gatttgccgg 3116461 tctgtggtgt tcatcttgtt acacctcatt tatcaaaagt tagaaacagg agccggggcc 3116521 gcctgaaaat gataagccgc agcttccttg ttcagcgtat aaatctgata cttcttctcg 3116581 atggctgctc ggaatcacaa agcggtcatc atatttggca atcgcaagca gccgatacat 3116641 atcttcaatt tgctgttctg ttaagccgac actggagatc agttccggat cgattgattt 3116701 attcgtctgg accgctctca tatactggcg catgacagac attttcttta atgttgaccg 3116761 aatatgatcc gtatcaccgg ctgttaacag ctgcgccaaa taatctatcg ggattctcat 3116821 ttggtcgata gccggaaaaa tatcttccgc cgtttgccgg ctgccttttc cttcaaagag 3116881 attcataatc gggctgagcg gcggaatgta ccacaccatt ggcagcgtgc ggtactcagg 3116941 atgaagcggc agcgcgatct tccagtcaat gatcatttta tagatcggtg attgctgcgc 3117001 ggcctctatc cattcagccg gaatgccttg ttcttttgcc agtttggcaa cctcaggatc 3117061 attcggatca agaaaaacgt ccaattggga atggtagaga tccttttcat tttcaacaga 3117121 tgccgcttcc tccactttgt ccgcgtcata tagcatgacg ccgaggtagc ggattctgcc 3117181 aacacacgtc tcagagcaga tggttggcag tcccgcctcc aaacgcggaa agcagagtgt 3117241 gcatttttcc gctttgttcg tttgccagtt aaaatagact tttttataag gacaggatga 3117301 gacgcaatat ctccatgaac ggcatgcgtt ttgatccaca agcacaatgc cgtcctcctc 3117361 gcgtttgtac atggcgccgg atggacagga tgagacgcat gccgggttga tgcagtgctc 3117421 gcaaatacgg ggcaaataca tcataaagac gtcatcgaat tctgttttga tcgattcctc 3117481 catcttttgt acgttgggat cttcaagtcc cgtaatgtgg ccgcctgcga gatcgtcctc 3117541 ccagttcggt ccccattcga tattcatgaa atcccccgtc aaggacgatt tcgggcgtgc 3117601 taccggctgg tgttttttct gcgggctgtt cgttaatgtt tcataatcat agttccaagg 3117661 ttcatagtaa tcatcaattg acggctgatt cggattatag aaaaggcctg caagccgatt 3117721 ggttttcgag cccgatttca gctcgagctt tccttttttc aatgtccagc cgcctttata 3117781 tttgtcctgg tcctcccatt gcttcgggta gccgatgccc ggctttgttt ctacattatt 3117841 gaagtacata tattccgcac cggaacggtt tgtccacgtg tttttgcagg tgacgctgca 3117901 cgtgtggcag ccgatgcatt tatccaagtt catgaccata ccgatttgcg ctttaatctt 3117961 caagccaatc gacctccttc agcttgcgga tgacgacgtt caggtcgcgc tgattccccg 3118021 ttggaccgta ataattaaag ccgtagctga gctgggcgta gccaccgatc atctgtgtcg 3118081 gcttgacgtg aatccttgtc gggctgttat gggtgcctcc gcggttattc gtcagctttg 3118141 tgccgggcac gttgatgtgg cggtcctggg catggtgcat aaacgccatt cctttaggaa 3118201 tccgatgaga caaaacggct ctcgcgacga caacgccgtt tcggttgaag cattcaatcc 3118261 aatcgttgtc tttgatatcc gtgtcctctg catcatcttt attcatccac acggtcggcc 3118321 cgccgcggaa cagcgtcagc atcggcagag aatcaaaata catgctgtgg acagaccatt 3118381 tattatgcgg cgtcaaataa ttgaggacga tttcttttcc ctcttgatca ggccgtttgc 3118441 tcagaaacgg gcgatgctgg aggatcggtt tgaatgtcgc catcgtttca ccgaattcca 3118501 tcatcagttc atgatcgaca taataggatt gtctgcctgt cagcgtccgc cacggaatta 3118561 atttttcaac attcgttgta aacggcgaat acctgcgccc tcctttttca gagccggtaa 3118621 acgctggaga cgtgatcacc gttttcggct gggctgtaat ttgttcgaac gtaaagcatt 3118681 cttcctcgcg ttcttccgcc aggtctttca gcttcaggtt cgtgatgttt tcaagtgatt 3118741 cccatgcttt tactgcgacc tttccattcg aagtggatga tagggttaaa atcgcttctg 3118801 cagcctgctt tgcttcactt atatttggac atccctttgc cacgctgtcc gaggtgattt 3118861 ctcccagtct ctgtttgagt gattcatatt catcggctat tgaccagctc atcccttttg 3118921 ttccgctcgg ctttaaagca acgttcggac caagtgcagt cattttatga aaaatgtgtt 3118981 tgtaatcccg ttcaacgact tggatgttcg gcatcgtttt tcccggaatg gcttcacatt 3119041 cgcctttgct ccagtcattg attttgccga atggctgggc caattcctgc atggtgtcgt 3119101 ggagcagcgg tgtcgcaacc acttctttca ccggctccat atcgacttct tctgccagat 3119161 cggaaacggc ttttgacagc gccttgaaaa tatcccagtc tgacttcgat tcccacggag 3119221 ccgagatcgc aggagcaaat ggatgaatga acggatgcat atctgtgctg ctgagatcgt 3119281 gtttttcata ccatgtcgcc gccggcagca cgatatcgga atacagcgcc gtacccgcca 3119341 ttcgaaaatc aagattgatt aataagtcga gctttccttc cggcgcctgc tcccgccatt 3119401 tgatttcttc tgggcggatg ctgtcgctgt cgtcattcat taaaccgttc gttgtcccca 3119461 gcaaatgctt gagaaaatat tcatgccctt ttcctgagct tgagatcaga tttgcccgcc 3119521 atacaaagag attccttggg aaattcactt cattgtcagg atcttcaatc gcgaatttca 3119581 gttttttctc ttggagctgt gaggccacgt acgcacctac gtcttcaggt gttgctgccc 3119641 ctgctttttc agcttcttta tacagatcga tgccattttg attgaaagtc gggtaagacg 3119701 gaagccaccc tagccgcgcc gccagcacat tgtaatcagc gtggtgcttg tagcgggatg 3119761 aagcagcaat cggtgatgcc aaatcactga tcggctggtc ctcataacgc cactgatctg 3119821 tcgcaaagta gaaaaatgag gtgccatttt gcagcttggg cacgccttcc cagtcctttg 3119881 cagttgcaat cgtctgccac ccttcagcag gtcggagctt ttcctgcccc acgtaatggg 3119941 cccagcctcc gccgtttacg ccttgggcgc ctacaagtaa aacaagattt aacactgctc 3120001 ggtagatcgt gtcggagttg aaccagtggt taatgccggc ccctacgata atcatggacc 3120061 ggccgtctgt atcgatcgca ttttgggcaa actctctggc aatcttaacg acagcttctt 3120121 ttttgattcc tgtcatttgt tcctgccagg caggcgtaaa cggctcaggg tcatcatagg 3120181 agacagccga tcgttcgccg atgccccggt tcacgccgta gttagccagt atcaagtcaa 3120241 acacggtcgt gatgtacgtt tcttcaccgt tcaggttcat ttttttaata ggaagatccc 3120301 gctcgagcac tttgtttccg tcatttgaaa aatacgggat gcgcaccgtg ccgatttcgt 3120361 cctctattcc cagcacagag agacggggtt caatcggttc cccggtttct tcatcaatca 3120421 tgtgcaggtt ccatttctgc tgcccgtccc agcgcgagcc cattgtccct tggggtatgg 3120481 caaatgaact tgtctgttca tcccaaaccg caggcttcca ctgatcatgc tttgtcttcc 3120541 gcccgatgtc cttcgcatgc agaaaccgtc ccgctgtgta tacgccattt tcttttgaca 3120601 gagtgacgag aaatggaaaa tcagtgtatt gcttcgcgta ctcaataaaa cgttcagttt 3120661 cttggttcac gtaaaattcc tgcagaataa cgtgacccat cgccatcgca agcgccccgt 3120721 cagtcccttg gcgaatactc agccagtcat ccgcgaactt tgaggattcc gcaaaatctg 3120781 gactgatcga aatgacctta gcgcctttat agcgggcctc cgccaaaaaa tgcgcgtcag 3120841 gcgttctcgt taacggaacg ttggagcccc atgtgataat atagccggaa ttgtaccaat 3120901 cactgctttc cggaacgtcc gtctggtcac cccaaatttg cggggatgct ggaggaagat 3120961 ccgcatacca gtcataaaaa ctgagcatag ggcctccgat taacgacata aaccgggagc 3121021 ctgatgcgtg gctgatcatg gacatggccg gaatcggaga aaaaccgacg tttcggtcag 3121081 gcccgtattt catcactgta tacagcagag aggctgaaat cagcttcagc acctccggcc 3121141 attcagcgcg cacaaaaccg cctttccctc tcgcctgttt ataggacttc gctttttcag 3121201 ggttttcgac gatcgatttc caggcttcca atggattttg atgcgtctgc aatgcctccc 3121261 gccacaaatt gatcagcaca ccgcgcacgt atggatattt cacacggagc gggctgtaga 3121321 tataccatga aaaactggcc ccccgcgggc agcctctcgg ttcaaaatca ggcatatccg 3121381 ggcctgttga tggataattc aaattttgcc cttcccacgt gactattccg tttttcacat 3121441 aaatattcca gctgcaagac cctgtacagt tgacgccgtg ggtggagcga acgactttgt 3121501 cgtactgcca tctgtttctg tatacattct cccaatcgcg atcctcgcgg gtagtttggc 3121561 tatgtttatt tgaatggtgt tcgataggag agaaataatt caatctccta aacaacggac 3121621 tccttttctt tttcttcatg agagttcact ccttccgagt caggtgatgc taagttcact 3121681 ataaacagag acagcgtgtt tccttgtgaa ctatgtcaca cactctgctt ttttcacaaa 3121741 atgttcacac aaaggagaag gaaggctgcg ttcaggcagg acgcttgggt cattagctgc 3121801 ctttcattca aagatcaaaa aaaaccggct ctatttaaga accgggctca gcgttttcat 3121861 cctgtgatgt atgcagatac cgcaaaaata attgatagga acaaaaaaca ttttgctgaa 3121921 gcatagccaa aaagttcatt tgcagctgcg gatgataaga catcattttc ttaaatatgt 3121981 aatatgggat gttgagaatc agaatgtctg aagtggcatt gactgagata aagggcgata 3122041 aataaagccc gcctttttca tcaatcggaa acacatcgcc tttttcccac agcgcaacgg 3122101 ttttcgaccc ttcagggagc cttgtgtcca taaaacggac actgcctttt aatacaatat 3122161 aaacagattg agaatgaaga aaagatggag actgatcaca tgaaccgcgg ataaacgtgc 3122221 cgtttttcag caaggtttcg acaatggata gaggcacttc attaaacata ggaagttgtt 3122281 tcagaaataa taaatagtca cactgattca taggaaaacc tcctgtgcta aggatagctt 3122341 tagtgtagct cgactgagcc tgtacagcag tgatgtattt cacagcctgt atgatgaatg 3122401 tcacttatca ggagggtgaa tgcatttata atgaaagaaa aaaggaggat ttcgatgaag 3122461 gcgctgattc cgaagcagca cggggcgtgg gcgatgctgc tgatcccatt tttactcggc 3122521 atggtcaagg gaggccccgt tatttggcat attccgctct tccttggttg gcttttccta 3122581 tacttagcgg tttatcccgt tacgcttgcc ttaaaaaaga aacaaagcaa accatatcaa 3122641 aagtggatgt gttattacgg ttttcccacc tgctgctttt tgatgatctc ggtctttcat 3122701 aagccgcctc tcatctgggt gggcgtttct ttactgccgc tgtttctcat acatatgtat 3122761 tttgcccgca gaaaaaacga acgagcctta ttgaatgatg ttgcaggtgt cttgttcttt 3122821 tgttcgggcg ggtttgcgag ctgctggctg gggatgggaa cccttgacgg ctgggcttgg 3122881 tttattttct tgcagtctgc tttatttttt atcgggagtt ccttttatgt gaaatcggtg 3122941 atccgcgaga gaaaaaacag ggcatttgca tactggtcat ggggatatca cctgctgctc 3123001 ccctttttat ccgctctttt cggagcagga tgggcgtttc tcgcttttat cccgagcagc 3123061 ttgcgggcat ggttttttca tggaagggat tggcccgtaa aaacgattgg cattctggaa 3123121 atcgtgaatg cctgcttctt tcttgccgtc atgtgcctgt ttatcacaag gtaaaaaaac 3123181 aaggacaccg ctgtccttgt ttttttcagt caatattgca aatctccagc gggcaatttt 3123241 cacactcaat ctcacatcgt aaatagtccc gcttgtgcaa aataattttt ccggattcgt 3123301 ctatcgaaat aacccctttt ttgcggagat ctccgagcat acgattgacg ctttcccgtg 3123361 cagccgcgca aaactttgcc aaatcctgat ttgtcaggac aatgttaatc agaatgccgt 3123421 cgcttcgctc cactccgtag ctgtttgata agcggataag ggtagaatag agcgccccct 3123481 ttttgccatg aagaagcaga tccctgattt tggactgaat cttccggagg tgcgtgctca 3123541 tccatttcat gaactcaaat gtcaaagcgc cgttttggat taattctttt tccagcttat 3123601 ttttattaat gacgagcacc tcgccatcct ctagtacttt tgcactgagc atataccttg 3123661 gttcttcagt gaaaagtgtt aattctccga cgatatcatg cttttggcag attctaagcg 3123721 tcaggtcttt tccgtcagat gtcagcttgc cgatttcaat gagtcctgat tgaatcagat 3123781 aaagctcttc tgcatccatt ccttcccgaa acaaatacgt gtgtttttcc atttttcttt 3123841 tcgtgctgat cgattccagc aattcataca gatcgctgga tataagatca ctatcagatg 3123901 gtcgaacaga gagaaaattc atgagctcac ctcgaagaaa gtcacgttgt gtgtttattg 3123961 taacgtgaat tgatttgtac ccatcgagaa aaaactaaca atcttgtgaa tgccccagtg 3124021 ttagttgatg ctctggctgt ttctctccgt gtgtgttttc attctttcct gccaatacat 3124081 ccatatgaca aggacaaaac tggctaacgc cacctctgaa agcgccataa acccgatcgc 3124141 gtactggcct gttgcctgaa atacactcgc caatatgagc ggaggaaaaa agccgcctaa 3124201 accgcccatg gcagacacaa tcccattggc aatccccgct tgcttcgaaa aatagaaagg 3124261 caccagttta aaaacagttc cgtttcctat gcctgagcag acggccacgg ttaatgatcc 3124321 aaacgtataa aggccgattg tcggcgagaa cgataggata atgcctgata atgtaagccc 3124381 ggcaaaaaca aacatcaaga tgcggagcgg gctcatttta tcagccagga atccgcccgc 3124441 aggcctgagc agcgtagaaa ccgcaataaa gccagccgtc cgcaagccgg catctgcagg 3124501 attcagccca aaatgctcca ccagaaagtt cggcagatag atagtgaagg cgacaaaggc 3124561 accgaacgta ataaaataaa acaggctcag aaaccatagc acatgatttc ggtaaacagc 3124621 tttgatttga gtcttaacag aaactttgac cttcttctca tgcctgtcgc caaacaatac 3124681 gtgcagtaag gcaaagacag ccagcaaaat cagatacatt tgcacggttg atttccaccc 3124741 gacggcttga gcgataaccg gcgctgcaaa tgtcgtaacg gctgtcccga tatttcctgc 3124801 accgtaaatc ccattgacga caccgtgctt ttctttcgga taatatttcg ggagggaggt 3124861 caccccaatg gaaaacaccg ctcccccgat ccctaagaaa aagccgcctg cgattaaatc 3124921 aaacagagaa tccgcgatac tgatccaaaa tacaggaaat aaaagcagga tgaagctgac 3124981 cataaacatg agccgcgcgc caaacctgtt cgttaaatac cctaaaggaa tgcggagaag 3125041 cgacccgagg atcacaggaa tcgcggtcac taaagaaatc tcacccttgc ttaaatgaat 3125101 atctaatgtg atttgggaaa tgagtgatga aatcagcacc caaaccataa accctgccac 3125161 caagcttaat gactgtaacg ataattgaat gtgttgacgg ttgatcattt ggcttgcccc 3125221 tttcaatgat tcaataatca gtcttatcat acaaaaacta gccaaacagg attgtgaatt 3125281 acatcacacg tttttctcat aaaaaaagga caaagcccga agactttgtc cttttgatcg 3125341 tgattacatt ttttccggag ccgatacgcc gatcagctga agcgcattgt tcagcgtaat 3125401 ttgcgttgcc ttcattaaag ccaggcgcgc gcggcttttc tcttcatttt cagggtcgat 3125461 gactttctct gcgttgtaga agctgtgcag agcagaagcc agatcataaa tatagttagt 3125521 gacacggtgc ggaattcgtt tttccgctgc ttccgccact gcctctggga agccgccgat 3125581 cgttttcagc agatcgtatt ctttttctga ttgaatatgg ctgaaatcaa gatctgccgc 3125641 cggtttaagc ccctgctctt ccccttggcg aagcatgctg caaatacggg catgcgcgta 3125701 ttgtgcataa tacacagggt tttcgttaga tgttgataca gcaagatcta agtcaaaatc 3125761 catatgggtg tctgcacttc gcattgcaaa gaagtaacgc acggcatcca agccgacttc 3125821 ttcaatcagg tcacgcatcg ttacggcttt accggtccgt ttgctcattt tcattttctc 3125881 gccgtttttg taaaggtgaa cgagctgaat gatttctact tcaagcgttc ctttttcata 3125941 gcccagcgct tcgattgccg ctttcatacg cgggatgtag ccgtggtgat cggcgcccca 3126001 aacgttgatc agcttatcaa agccgcggtc aagcttgtcc ttatgatacg cgatatcagg 3126061 aagaaggtac gtgtacgtgc cgtccttctt gatcaatacg cggtctttat catcgccgaa 3126121 agtcgtggaa cggaaccaag tcgcgccgtc ttcttcatag acgtggcctt tttcgcggag 3126181 cgcttcaagc gccttgtcga tttttccatt ttggtacagt gaagtttctg aataccacac 3126241 atcaaacggc acacggaagt tttccaagtc cttgcgaagc ttttccagct cgtatttcag 3126301 gccgtattca cggaaaaacg cgaggcgttc actttcctct tcgttaacga aacgatcacc 3126361 gtattcctca gcgagacgct ttccgatcgc aatgatatcc tcaccgcggt agccatcctc 3126421 cggcatcggt ttttccaatc cgagtgcttc aaagtaacgg acttcaacag aaagcgccag 3126481 attgttgatt tggtttcccg catcgttaat gtagtattcg cggcttacat cgtaacccgc 3126541 ttttgaaagc acgttgcaca aggaatcgcc gacagccgcc ccgcgcgcat gcccgaggtg 3126601 aaggtctccc gtcggattcg ctgatacgaa ttctacctga actcgttcac cgtttccgat 3126661 gttcgtttcc ccgtatgctt cccctgcttc cagtacagac ggaatcagct ttgttaaata 3126721 ttgattgttc atatagaaat tgataaaacc cgggccggcg atatccagtt tttcaatcga 3126781 agccttccct ttatcaaaat gggcgacaat ctcttcagcg atttgacgcg gcgctttttt 3126841 tgccactctt gccaactgca tcgccatatt cgttgagtag tcgccgtgtg ttttatcttt 3126901 cggtgtttct aaaacaacat tgggaatctg gctttcttca gccagtcccg ctttcagaac 3126961 ggccgctttg atttcttctt tcagcacgtc cttcatttgt tccgcaatgt tcatgcgtga 3127021 gttcctccct catacgtgat cgtcatatta tgtaaatgct cctgctcgtc tccgacatgc 3127081 atgtcatatg cgatgctgat acggcctttt tcttcatcga gatcagattg aatcgatttt 3127141 gtgcttgttt tcagctcaag ctcaccaaat gacattttat atttagcaat tgtggaagct 3127201 cccgttacga aacgctgatt cattttgaca gcgcctgacc tcatgaccag gacttcgcct 3127261 tcgcttactt tcacaatcgt tttgactttg cctaagtcgt gttcttcata ataagataga 3127321 tacactttat tttgttttac atagtaaaat ccggtggtgc ggaattcgat gacttcttgg 3127381 tttccgtcat cctcgatcac agacttcaca tggagtgtta tcggtgtctc ttgcttcatt 3127441 ctgacacgtc cttttcatca ttccactttg acttgaatag tataatcatt cggtttgtaa 3127501 acttcaactg cttctatctt accatcattg ctcatcagat ttgaagataa acctcataaa 3127561 aagcatttcc ttatatagaa gagaaaatca tatcactaat tacctttagg aaatgttacg 3127621 agctcgctac atcgcaatcg cagacggacc cgcgccaacc ggaatcaccg tcacggctgt 3127681 ataatcactt gtgcggtaca cggtcacagc attgtcgttg ggctgtgccg cataaatata 3127741 ctgtttgtcc ggcgttacgg cgaggtcaaa ggcgccgggg agagacacgt ttgcaatgat 3127801 cctctgtctg gccgtattaa ctacgtataa gttattaatg agaaacggtt cactatatgg 3127861 ctctagaaaa taagctctag tactatcgag agaaaataca atcgtcctca gcgtttcaaa 3127921 taaacggctg aagtcccctc ccctgcttaa tggtgacaaa ctaatctccg ttacaccttt 3127981 cggccacagc tcaccattca atacgtacgc aaaatttcca gcgtaaggag ttgtaattaa 3128041 actgggaaat tcaaatgtat ctatgatact ttctaccaac tgcccagtat ttacatcata 3128101 tttatcaacc gaccaactgc ttccattagc ggtatagaca tactgtccat tcggatcaag 3128161 agcaaagtct aaagcgccgg gtatcggaat gacatcaatg accgattgag aggccgtgtt 3128221 aatcacatat atagatccgg cggccatcac gtatgcgaac tcatctgttg gatcaaattc 3128281 gatttttctc ggccctcctc caacagtaat ggtatttatg atggttaatg ttttattatc 3128341 aatcactgag acaaggttgg tatttccatg gaggacatac gtgaatgctt tatcgaaagt 3128401 aacgcctaga ttagttggca cgtcagaaaa agggattgtt tttacaacag tgtttaaatc 3128461 tgcatcaata accgaaaccg tgctgtctcc agtattggca gtaaacacat acgattgagg 3128521 gtctggtgat ggcggtaaaa caagtgtccc ggccaccgta agcggactgc cgtagaaagg 3128581 cggtacaatg agcagatctt ccactgttat ttgactgaaa tcaggacagc ggccagactg 3128641 tgctgcataa taaacaactt gatcaatctc ttcagtatga atcacagaaa cagccccgtc 3128701 tccttgtcca tattgatttc gtacaggcga cacactgaca agaagcgtaa tggtcccttg 3128761 tactctcaca gcatatcgaa caccgatatc ttctggttcc ggcccagtct ggattaagca 3128821 aggctcactg atacaggaca aattgtctgt actccatgta acagccgctg acgcttcggc 3128881 cgtatcaacc ttgaagccct cagggaaatc tatcggcact tgaaacggcg cttcccggct 3128941 aatttcctca tcacaaaaac agaaacaatt ttcctgtaaa gcagaaagat cattcttttt 3129001 catgatttca cgtcctttta gaaatgcaca acatgcagcg gttaaatcgt aatggcaccc 3129061 ggtgaaaccc caagagatat cacagtttcc tcagaataat catctgtgtt gtaaacaatg 3129121 atgctctgct ctataaaacg agttgcatac agaaaatcgc cattcggggt aaacgcatag 3129181 tctgttgctg attgcggaac atttcctata acgcctgctc catttggact gacagaatat 3129241 aaattgccag tgaagccgtc atataaatac acctctgctc cactcgtaaa cattcgatat 3129301 tccccttcat actccagctc ttgggtgctg ctgatggtaa acgtatttaa atcaataacc 3129361 gtcaaataat taaaaaagaa ttcttgttct aatacatagg cataccgctc cggccaattt 3129421 gtttctatgg ttgatacgat aagctctcgt tcaattgttc ctgtgacttc accggtagtt 3129481 aggtccactt tttgcactat tccaaaattc agaacatagg cgaataaccc attgggatcg 3129541 attgcaacat catatccttc cacaggaatc gacctatcca cagttaacgt atcaattcca 3129601 atcacataaa ccgcagtacc ggtgaaaaca taagcaaact catgattagg gataaatcta 3129661 atcaatcgag gcggctgatc cagcaatata gttgctgtca ctgttaatgt gtcataatcg 3129721 atgacagaaa tcacattatt gttgggatgt aagacaaaca cagcgctttt atctggcgta 3129781 atttcaatac ctgccggatt gtacggaaga gcaatcgttg tcacaacagt atcggtgttt 3129841 gtatcaatca cagaaactga ttgatcattt ggattcgctg taaacgcgta gacgggttcc 3129901 ggctccggta caagcacaat tgtccccgtc accgataaag gactgccgta aaacggcgga 3129961 acaacaacaa ggttctcaat cgtgatgtca ctgatatccg ggcaatcatc cgattcatcg 3130021 gaataataga cgacttgatc gatttctgca ttgtgaatga cggaaacagc cccgtcccct 3130081 tgtccatatt gatttcggac aggtgagaca ctgacgagta gcgtaacggt tccctgcagg 3130141 cgcactgcaa attgaacacc gacctcatca ggctcaggcc ccgtttgaat taagcaacgg 3130201 tcactgacac aagaaaggct gtctgcattc cacgtcacgt ttgcaacagc ttcagccgga 3130261 tcaacgacaa acccttcagg taattcaatc ggtgcttgaa acatggcttc tcggcttgct 3130321 tctccctcac aaaaacataa gcactcttct tgttctgctc ctgctttttc tttaaaggaa 3130381 agcttgtttt ttctcattcc ttcacttcct tttcagacat acactgctca cgcagatata 3130441 acagaatatg gaagggtaac gtgtttgctt gtacaaattg ctgagggtaa acgcttcttt 3130501 ttgaaaatat atctccaaac atgcggtgta acgaaagaaa aaattgcggt ttttttgcgc 3130561 ttctcacaag aatgttgatg ataaaatatg acatatatag aattatgaag ggagggattt 3130621 gcaaacgtga caggtgtcat atcttcttct tccatcggag aaaagattaa cgaatggtat 3130681 atgtacatac gccgattcag catacccgat gcagaatatt tgcgacgaga aatcaagcaa 3130741 gagctggatc aaatggaaga agatcaagac cttcatttgt actattcact gatggagttt 3130801 cggcacaacc taatgcttga gtaccttgaa ccgttagaaa aaatgaggat tgaggaacag 3130861 ccgagactgt ctgatctgct gcttgagatt gataaaaaac aggctcgttt aactggtctg 3130921 cttgagtact attttaactt cttcagaggc atgtacgagc tggaccagcg ggaatatctg 3130981 tcggctatta aatttttcaa aaaggccgaa agcaagctga tattcgttaa ggatcggata 3131041 gagaaagctg agtttttctt taagatgtct gaatcttatt actatatgaa acaaacgtat 3131101 ttttcaatgg actatgcacg gcaagcatat gaaatataca aagaacatga agcttataat 3131161 ataagattgc tgcagtgtca ttctttattt gccaccaatt ttttagattt aaaacagtat 3131221 gaggatgcca tctcacattt tcaaaaagct tattctatgg cagaagctga aaagcagccc 3131281 caattaatgg ggagaacttt gtacaatatc gggctttgta aaaacagcca aagccaatat 3131341 gaggatgcca taccttattt caaaagagca atagctgttt ttgaagaatc aaatattctt 3131401 ccttccttac ctcaagcgta ttttttaatt acacagatcc attataaatt aggaaaaata 3131461 gataaagctc atgaatatca tagtaaggga atggcttatt cacaaaaggc cggagatgta 3131521 atatatttat cagagtttga atttttgaaa tctttatact tatcaggccc ggatgaagaa 3131581 gcaattcaag gattttttga ttttctcgaa agtaaaatgt tgtatgctga tcttgaagat 3131641 ttcgctattg atgtggcaaa atattatcat gaacgtaaaa attttcaaaa agcttctgct 3131701 tattttttga aggtggaaca agtaaggcaa cttattcaag gaggagtgag tttgtatgaa 3131761 attgaagtct aaactattac tctcttgtct ggctctaagc actgtgttcg tggcaacaac 3131821 tattgcaaat gcacctacac accaaattga agttgcacaa cgaggaatga tttaaccgcc 3131881 gtccatcggc ggttttttcg tcccctcttt accaaagtct cccaatccat gctatgatct 3131941 tttcaataat cttgaagaga gtggaaatgc agcatgtctc taaaaagtgt gagaacccac 3132001 tttactcaat ggaatcgaga aaatgatgtg acggagttcg aaacgtcgag tgcgacagtt 3132061 gaacaggcag ctgagacaat cggcgtaagc ctgtctagaa tcgccaagtc cctgtccttc 3132121 agaggggaag gagatcaggt gattctgatt gtggcagccg gcgatgccaa gatcgacaac 3132181 aaaaagtcca ggcaaacatt tggctttaaa gcaagaatgc tctctcctaa tgaggtgctg 3132241 gagcagacag gccatgaaat tggaggagtt tgcccatttg gattggctca tgatcctgag 3132301 gtttatcttg atgtatcgct gaaacggttt cagactgttt tccccgcatg cggcagcaga 3132361 aactccgcta ttgaattaac accgaaagaa ttatccgaat tttctttctc aaaagtgtgg 3132421 attgatgttt gtaaagactg ggaataaaaa aacatccaga catcgtctgg atgtttactt 3132481 atttcacaaa cccaagcagc atttcacgga tgattttgct ggctgtgttt gccgtttgct 3132541 ctgagtggtc gtataccggc gcgacttcca ctaaatcagc gccctttacg tttacctctg 3132601 aacgcgcaat ttcatggacc gatgcaagca gttctttaga cgtgatgccg ccggcgtcaa 3132661 ccgttcctgt acccggtgcg tgtgcagggt ctaatacgtc aatgtcaatt gtgacataaa 3132721 ccggacggcc cgccagcttc ggaagcacct ctttcagcgg ttcaagcact tcaaattttg 3132781 agatgtgcat gccgttttcc ttcgcccatt caaactcttc tttcatgccg gaacggattc 3132841 cgaatgaata cacattgtgc ggtccgatca attctgccgc cttacggatc ggcgtggagt 3132901 gagaaagcgg ttctccctca taatcaacac gaagatctgt atgtgcgtca aaatggataa 3132961 tcgcaaggtc tgggtatttc ttgtacatcg ctttaatgac aggccatgac acgaggtgct 3133021 ccccgcccat acccattggg aacttccctt tttctaaaat gctgtccacg tactcttcaa 3133081 tcatatccag gcttcgctgc ggatttccga acggcagcgg aatgtcgcca gcgtcaaaga 3133141 agttcaagtc agccagatcg cggtctaaat atgggctgta ttcctcaagg ccgattgaca 3133201 cctcacggat tctgcttgga ccaaagcgtg agcccgggcg atagctgact gtccagtcca 3133261 tcggcatgcc gtaaagaatg gcgtccgcct cttcccactc gggacggctc gcgataaata 3133321 cttttcctga ataagcttca tcaaatctca tctataatac cctcgctttc ctgtaaaaaa 3133381 gcgcaagatt cgctcctgcg ccataccttc attatttaat caggtcactc acaaatttcg 3133441 gcagaacaaa cgccgcttta tgaatatctt ttgtgtaata tttcgtctca atatcgaaga 3133501 aacggctgtc ttccactgca agcggatcat attttttcga gccaattgta aatgtccaca 3133561 aaccgcttgg atatgtcgga atgttcgccg tatacagctt cgtaatcggg aagatttcct 3133621 tcacgtcgcg ctgtacattt gtgattaatt ccggtgtaaa ccatgggttg tccgtctgcg 3133681 caacgaaaat accgtcttct ttcagcgctt ttgcgattcc tgcgtagaat ccttttgtaa 3133741 acaggtttac agccggtccg actggttcag tcgaatctac catgatgacg tcatattgat 3133801 tttcagattt tgcaatgtgc ataaatccgt catctacctg cacgtcaacg cgcggatcat 3133861 ccagtttgcc tgcgatagaa ggaaggaact ttttagagta ttcgataacc ttgccgtcaa 3133921 tatctacaag tgtcgctttt ttcacgcttg ggtgcttcag gatttctctg ataacgccgc 3133981 cgtcaccgcc gccgactacg agaacgtgct ccggatttgg gtgcgtgaat aatgggacat 3134041 gcgccaccat ttcgtgataa acgaattcgt ctttttcaga tgtcatcacc atgccgtcca 3134101 aaaaaagcat gttgccgaac tcttctgttt ccaccatttc taaatgctga aactccgttt 3134161 gttctgtatg taacgtcttg ttaaccttca tcgtaatgcc aaagtttttc gtctgcttct 3134221 ctgtgtacca aagttcgctc aattgtcatc tccctttcga ggctgtattc atttattgta 3134281 agcgtcttat cagcttttat tctcggttga aatctcattt tcacctaagg aaaaagtata 3134341 gaggatggcg gggaaaaagt aaagatgcgt cctgttctgc gatgtttaaa aacgatcttt 3134401 ttttctcata atagtagaaa cataaaaaaa gggggaaccc gttgtggatg caatgacaaa 3134461 taaacggctg agactgacgc tgaaaaccgt tcgcgccttt atctttttag gggcttttgc 3134521 ggccttggcg gcagctgctg tgtttatgac tgtcattttg atagccaaat accagggcgc 3134581 tccctcggtg caagtgccgc aatccacgat tttgtacgcg agtgacggct caaagctcgg 3134641 ggaaacgaac tacggcgaaa agcgctattg ggtcccctta aaggacatga atccgacgat 3134701 cgtaaaagcg acagtggcga ttgaagacca gaatttctac gatcatcacg gctttgatta 3134761 taaacgcatg gccggcgcgg cgcttgctga cctgaaagca tttgccaagg ttcagggtgc 3134821 aagcaccatc acccagcaat atgcgagaaa cttatacctt gaacacgaca aaacgtggaa 3134881 acggaaatgg aatgaggcgt tctacacgat ccgtctggaa caaaactatt ctaaggacga 3134941 gatattagaa ggctatttaa atacgattta ctacggccac ggcgcctacg gcattgaagc 3135001 agcttcccgc ctgtatttcg gcaagcatgc caaaaacctg acggatgcgg aggcggcgct 3135061 tttggcagga atcccgaaag gcccttccgg ctattcaccg tatgtcaatg agacgaaggc 3135121 caaggaacgc cagaaaacga ttgtgcggat gatggaaaag cagcagatga tcagccaaaa 3135181 gaaagcggat gaattgatca aggaacctct ttcctatcag cctttgaata aacaagtttc 3135241 caagagaaag gctccttatt tctacgacaa tgcgatgaga gagctggaaa aaaagctcgg 3135301 catgacacgg gagcaaattg aaacgagcgg gttaaacgtc tatacaacgg tagataaacg 3135361 gatgcagcgc atcgccgagg agaccattac cgaaacggtt aacgcgggct ctgacattca 3135421 agtcgggttt tcagccattg atccccgcac cggaaacgtt ctcgcccttg tcggcggcag 3135481 ggattatcaa aaaagcccgt ttgaccggac gacacaggcg aagcgccagc ctgcttcgac 3135541 gatcaagccg ttgctgtact ataaagcgat tcagagcgga tttacgccag tcactttgat 3135601 gaaaagcgaa gaaaccgagt ttcaaattga tgcaaaggga gaaacctatt ctccaagcaa 3135661 ctataacgga tactatgcca acaagccgat tacgcttctg caggcgctgg cgctttccga 3135721 caatatttac gctgtgaaaa cgcatctttt tctcggcacg aacaaacttg taaagacggc 3135781 aaaggaattc ggcattaccg cccatcttca agcactgccg tccctggcac tcggcaccga 3135841 acccgtacgt ccgattgaga tggtcaacgc ctatgccatg ctcgcaaatg gcggaaagaa 3135901 aatcgaaccg acttttattt caagagtaac ggacgcagcc ggccacgtgc tgtacgaaaa 3135961 cccgaatcag cataaacagg tgcttgatga aaaagccgct tttgtcacag cgagtatgat 3136021 gacaggcatg tttgatatcg atttaaatgg atatacgtcg gttacggggc gaacgatagc 3136081 caaccgcctg acaagaacgt atgccggaaa atcaggaacc accagcgcag acagctggat 3136141 gatcggcttc aatccgaagc tggccgccgg tgtttggacc ggctatgaca aaaacagcac 3136201 catcgactcg gtcgaagaaa aaagctatgc taaaaccatt tgggcggact tcatggagga 3136261 cgcgctcaaa ggcgaaccgg aaaccgcgtt caagccgcca aaaggcgtaa ccggtgtgta 3136321 cattgatccg gaaacaggct actcatcagg tcccggctgc gccgctaagc attacacata 3136381 ttttgtgaaa gggacagaac ccgcaaacgt gtgctacggg gcagaacccg caaaacaaac 3136441 aaaagaccgg cttccatcca aagaaaagcc cgcttccgag aaaaagtggt gggacaaatg 3136501 gctggggcga catcattgaa aataacccgg ctcctcggag gccgggttat tcgtatggtt 3136561 ccttcataat cgatggaaga atgttagaca atcgagctga acaatcagtt ttgggataaa 3136621 gtggtgaatt tctcatttct tcggcgctgg ctttcatctc ccagtcgccg actcatatcc 3136681 ccctaaaaat gaaaaacccc gagtcttgtt tcggctcggg attttccatg tcctatttct 3136741 gtatcaccag tttactcaat gtttacgaaa aatatctcaa atactttaaa agttcacaaa 3136801 aaattcataa attaattgtt ttctggaagc aggctcgttt ttaactcatc tgaggaacgg 3136861 tcccataggc cctgatcatg ctttttcaga aattcgccta gtacacgctt cgagctgtcg 3136921 tccattttat caacgatgat tttccgtttc atggatttat ccatcagatt cacatgctca 3136981 ggcagtgact tgtagcctct tctgatgctt ctgtcgaccg tcatttcaca ggctgtcaca 3137041 ccagcgtaat aaggcccctc ttcttttctg tcaatcgtta cccacacaag ccagtatggt 3137101 tttccgttcg gcacttcttc tttattcggg agaaatttaa ttcctttttc aacggtgctg 3137161 cgggcatgca tagcgccgat gtctacgaac gcttcttttt cctctacatc aacgaatacg 3137221 ggagaaatgt tatcaaggct gagtgcccct acgccaaaac cgccgtgtcc gtctgtcgga 3137281 tcacttttga taatattaaa cccgattgat tttttctttt tttcttccat gaagttctac 3137341 ctcctacaaa agcggttgaa atatcgctga aaacagcttt aaaatcgaat ctcttcctgc 3137401 attgagcatc ggccacagca cgtaagatcc tagcggtgtc acaaacagca ccaaaaatac 3137461 gataaagccg tagctctccg cctgcgtcat tttggcacgc acgcccggcg gaacgagatc 3137521 ttctataatt cgatagccat cgagcggagg aagcggcagc agattaaata aaaacaagac 3137581 aagattcagc tgtatccaaa tagaaaaaaa ctgatccagc cccgtgctga acgccgcaag 3137641 catttccatt ccgtacgcat gcatcaacac taacaaaaag aaaccaataa acgcaagaat 3137701 caggttactg acgggcccgg ctatagatac gagcacacca gcaagccggg gtttcttaaa 3137761 gaaacggcga ttcacgggaa tggggcgcgc ccacccgaat ccggccacca gaatcaaaat 3137821 ggttccgaac ggatcaaggt gtttaatggg attcagcgtc agtcttcctt gttttttcgc 3137881 cgtatcgtca ccgaatttgt atgcgacata agcgtgggca agctcgtgca tcgtaaacga 3137941 cacaattagc gtgatgacga ggtatggcat taaagataac ggataatata aaaaacggtc 3138001 caagtgagat atccctcttt ctcaaaatgc aagaatttac tttattcagt atactataag 3138061 aagcctcttt ttctaaagag aggaaacgag ataaaggagg attcagcacc catgccatac 3138121 gtaactgtca aaatgctcga aggccgtaca gacgagcaaa aacgcaatct tgtcgagaaa 3138181 gtaacagaag ccgtaaagga aacaaccggt gcttctgaag aaaaaattgt tgtctttata 3138241 gaagaaatga gaaaagacca ttatgccgtc gcaggcaaac gcctgagcga tatggaataa 3138301 tctctataaa gccggcgctt cgcgcaccgg cttttattat ccctattgag ccagcttcgc 3138361 aataatcgcc aagaacgtct ttttctcttc ggctgttaaa cgttcaaaca tgccatcaat 3138421 cagctgctgg cggttttcga tcatttgttc agccgctccc cggcccgatt cagaaagagt 3138481 aatccataca gtgcggcggt cattgttatt tctggatctc tcaataaacc cttcctgctc 3138541 taaatgattc agagctgtgg tcgtggcaga gggagacagt gtgacctcct tcaaaatatc 3138601 ctttatggtg cagctcccat gtctgtatat gatccgcaga ataaaccctc ttacattatt 3138661 cacgtgtttc ggaacggtgg cttcatctaa ttgcttcgtg cttttcaaat actttgtaag 3138721 tgcgtgatcc agcaaatttg cttccagttt gtcatggtcc atgtcaattt ccccatttcg 3138781 agatgcattc ataacatacg aacgatatga tttacttatt attttactga ttccgaatag 3138841 ggaaagtcaa aaaagcaaaa tgtgaattca cagcttttat cctacatgcc tcgattttcc 3138901 acctgtttca caagtttatc tttaaaagtt tggaaaggaa cgtgttcatt ctgctgatgt 3138961 ccgaatcggc ggacgtttac cgcattctcc tgctcctcat gatctccaag caccagcacg 3139021 tacggaattt tttgcacctg cgattctctg attttatagc cgagcttctc attgcgctca 3139081 tcaatgccgg ctcttatccc cgcctgcttc agctccgcct gcacttttct gcaatagtct 3139141 aagtgaacgt gcgaaaccgg tatgatttga acctggatcg gtgcgagcca gactggaaaa 3139201 gccccaccgt aatgctcgat caaaatgccg aagaaacggt cgattgagcc gaaaaccgct 3139261 ctgtggatga caacgggacg aaccttctca ttgagttcgt tgatatatgt taaatcaaat 3139321 ttttccggca tttgaaaatc aagctgaatt gtcgcgcatt ggtggctccg tttcagggca 3139381 tcttttatat ggaaatcaat tttcggcccg taaaacgccc catcgccttc attgatctca 3139441 taagagaggc caagctcctc aaggacgcgt gctaaggcac gttccgacgc ttcccaaagg 3139501 ctgtcatcgc ctaatgaatc ctccgggcga gtcgaaagct caacagaata ctcgaaacca 3139561 aatgtccgat atacctcatc aatcagccga atcgcttctt tgatctcact ctcaatctga 3139621 tcctcccgaa cgaaaatatg ggcgtcatcc tgacagaacg tccgaacgcg aagcattccg 3139681 tttaaagcgc cgctgtattc atggcggtgc acctgtccga attccgccat gcgaatcggc 3139741 agatcccgat aagaatacag gctgttttta aagatgagca tgtggccggg gcaattcatc 3139801 ggcttcattg cgaatcttgt atcatccact tctgaaaagt acatattgtc gcgataatgg 3139861 tcccaatggc ctgactgctc ccataaccgc tgattcatca taaacggcgt acgcacctca 3139921 tcgtagccgg catttgtttg cagctcacgc gagaagcgct ccagctcatt gcggacaatc 3139981 tgccctttcg gcaaataaaa cggcatcccc ggcgcttctt cagaaaacat aaacagccct 3140041 aactgtttgc cgagcttgcg atggtctcgt tttgccgctt cttctagcat atgcaggtgc 3140101 gcatccaaat cttttttctt ttgaaacgca accccgtaca cccgctgcag gacttcattt 3140161 ttgctgtctc cgcgccaata agcgcctgat actcttgtca gtttgaacgc cttgatcatc 3140221 cctgtagaag gaagatgcgg ccctcggcac aggtcaacga attccccttg ctggtacagt 3140281 gtgatatcct ccccgcgcgg aatatccttt aaaatctcaa gcttgagccg ctcgtctttt 3140341 tgtgcaaaca gctcttcagc ttcttcgtaa gaaacctcta tacgtttgat ttcaaggttc 3140401 tcatttatta tgtttttcat ttctttttcg atggcctcta agtctcctga tgccaagctt 3140461 ttccccagct tcatgtcata gtagaagccg tctaaaatca caggccctac ccccaatgac 3140521 acttcgccgt acagccgttt tactgcttgg gccagcacgt gcgctgttgt gtggcgaagc 3140581 acctgcaagc cttcttgtga atcgagtgtg acaatcgaaa gctcagcatc ctcctccagc 3140641 ttgaaactga gatcaacaag cttgccgttg acctgacctg cggccgcctt cttttgcaga 3140701 ctggaactga tcgaaccagc cgcttctttg attgtgatgc ctttcggata ttcctggatc 3140761 tgtccgtccg gaagctgaat gtgtacatgt ttgctcattt tagaacactc cttattcatt 3140821 gttgtatata aaaaaacaca cccgtcccgc agatagggac gagtgtgtga ttaacccgtg 3140881 gttccaccca agttcccgac aaatactatg ttgtcggctc ggtgctgtaa cgcagcatag 3140941 acggcattgg ttacttcagt tccccaatgc tgctccaagg cggtaaatga tattcctaag 3141001 ctgggaagct ctcacctttc cttccctctc tgaaaaccgt aactatcatt catgtccttt 3141061 tcatcgcatg tattcaattc ataaaaaaac acacccgtcc cacagatagg gacgagtgtg 3141121 tgattaaccc gtggttccac ccaagttccc gacaaatact atgttgtcgg ctcggtgctg 3141181 taacgcagca tagacggcat tggttacttc agttccccaa tgctgctcca aggcggtaaa 3141241 tgatattcct aagctgggaa gctctcacct ttccttccct ctctgaaaac cgtaactatc 3141301 attcatgtcc ttttcttcgc atgtattcaa ttcaaataaa aaaacacacc catccctcta 3141361 aaagggacga atgtgttgat catccgtggt tccacccaaa ttcccgatca attacacatg 3141421 atgatcggct taaagatgct gtaacgcagc atgacggtat cagatacttg ttttccctga 3141481 tacggctcaa aggcggtaag ctgctttccc tgcgttagga agatctcagc tgtccttccc 3141541 tctctggaaa ccgtaaaaag catctcgtgt ccttatcagt gcctgttgtt tcaataattt 3141601 tttatatctt actatatatt cccacaaagc gcaatcagtg atttacattt tttctgacgc 3141661 ggcagtcccg ttatgggcag ccagaaacag ccatacaagc aatgcagcga ggctgtatgc 3141721 cgctcccatc atcaaaaacg caaacccggc accagcatac caagtggcgg acagatgaat 3141781 gatcaccccg gttatcgcta cgccgaccaa ggctccgatt tgccggtttg catttaacgc 3141841 cgcaccggcg atattcgtat gtctttgccc ggcagcctgc atgatcacag ttgtcatggc 3141901 aggaactgta ataccggtac agaggttcat aacagacatc aacaccgcca gctgccaata 3141961 aggaaaatcc ggagaaatca gcacaaacaa cagcaatgca atgatacagc tgaccgccat 3142021 tgatacaaac ataagctgac cggcttcaaa ccgattcgcc agacgggcaa acagcagatt 3142081 gccgatcacg aagaccgcca tcatcggcag cagctccact ccagccataa aggaacttgc 3142141 ccctcctgct tcctgcaaaa aaaggctgag cataaacatg ccgccaaaaa gggcgaaatt 3142201 cagcaaaaac ccgataaatt gggcagctga gaagcggccg tttttgtata aggacgccgg 3142261 caggatgggt gtttttgcag aaatttcccg cagcaaaaac agcacaaatg ccaaaaccgc 3142321 tgcagtaaat gctacaagaa tcactggcga gcgccagccc gctgaaggcc cctgtatcaa 3142381 agcataggaa agaaacccga gagccatcat gccaagcaga tgcccgatga tgttcacgcg 3142441 gctgcttttc ccaggaacgc ggctgaggat tcggtaagct gaaatgagcg cagcagcccc 3142501 tattggcaca ttgatcagaa aaatactctg ccagcccgcc aactgtacca gcacgccccc 3142561 gataaaaggc ccaagggctg aagcggcgga aacaagcgcg gcccacagtc caaacattct 3142621 cgcccgcgcc cgctcatcaa ggtaagaggc agccaaaagg ctgagtgagc ttggcataaa 3142681 caaagctgcc ccaattccct gtatgagacg tccggcaatc agcatctgcc catttataga 3142741 tgcagcgcat agacaggagg ccataacaaa aacggctaga cccaagatat agatcgtctt 3142801 cgagccgaaa cggtcagcca aggctccgcc cgccagcaga agcgacgcaa aagtaagaat 3142861 gtacccgtcc acaacccacg ttacacctga aagtgacatt gaaagagtgt ttttcatatc 3142921 agccatcgcc acattcacaa cggtcacatc aagagttgcc atgaggaaac caagtgcgag 3142981 cacgatcagc acggatatgc ctgttgatga tgttgattct tgtatagacc cgctattttt 3143041 cattacaatt gccctttcac ttgcttgatt acccaatcat ctattttttc aagatcatac 3143101 aattccccga ctctgtccat aacatgctgc aaggattctt ctctcataag attggaccat 3143161 ttatcctcga tttccgccat gactgtctcc agcacacagt gactttcacc ctcaaataca 3143221 gattgcagca agcctttccc ctgatacatc gaacctctgc cttcgaccgc ttgataaaca 3143281 tcataaagcg taatgtcagc caaaggcttc gtcagggtaa aaccgccctt cgtccctggt 3143341 aaggattctg ccaaaccggc ttgaaccaat gttctcatca gcttcttcaa gtaagacgga 3143401 gacacgcgca atcgctggct tatagcctct gacgtcaaag aagcctgtac cggcagccgt 3143461 gacagtaaca gcagcacaga aaccgcctgc tccattcctg atttcatttt catcctattc 3143521 actcctgatt cattatggat aactattatc cataatgaat ctcttagcag cttttgtcaa 3143581 taaaaaaagc aaaagaaacg gatcatttct tttgcttggt atggttaaca aatctgcttc 3143641 agttcctcta tgtattgaag cgcttcgtca tattcttcat ttgtatattt ttgcttgctt 3143701 ttgatggtaa agactttttc tttcttttcc tcatcctcaa gcccgtcaaa gtaaaggatc 3143761 gtggaaacca gctctaaaaa ccgtgatgaa cggctgttta cactgtcgat atagcctttc 3143821 atatccggca tgtccagatc agcatggtct aaaaatgcgg agcctgtctc agtcagcgaa 3143881 taccggtatt gaaagtagcc gccctttttt tccttcacct catgcagaaa tccaaggttg 3143941 cacagctctt caatctggag cgtcagttcc tctgaatatg gtccgtaaaa gtgaaaatca 3144001 tatttctcat agaaaggaaa ctgcattttc ttggcgatat aaatcatttt ctgcagcttc 3144061 tttcgcccga tgatttctcc agaatccgag aacaccttca tcagttttgc atgttctttc 3144121 aacaaattcc cgacatctcc tttttccttc tttccaattt ctatgtcagt cccagcagct 3144181 gccggatttt cattttcgct tccggatgtt tagtgccgtc acaaatcaag tcctttggat 3144241 agtacagctt gtggtccgtc cgccgtttac ctgagatgga ttccacaata gccgactgtc 3144301 tggacagctc tttaatttgg ccgttttgcg tcaagagatg gatcggcaga cgctcctctt 3144361 cctctcctgg tcggtaaaaa tcgtatggca gatctgatga agaatcaacg accaaataat 3144421 agctcggatc gatccccgcc tctttgaaca atgaagtcag ctcaaaataa gccgacattt 3144481 cttcattcgg attgaattca acgtattgga aaagctggcg gttaatgaat ctgcggcaca 3144541 agtcggataa aatcgcgtct tcttcatcct cccaggcctg gaagtaatac aaaataatag 3144601 attcatccag ctttacataa tcctccagtg tcaattttcc ttcaaaaata gaatagaaat 3144661 gaaccggagc gtgagtgaag acatagcctt catcgtgcag ctgcttcgcc ctgtgaagaa 3144721 tcttcgttaa aatgacctct gcacttctag tcacaggatg gaagtagacc tgccagtaca 3144781 tttggtaacg gctcatgata tagtcttcga cagcgtgcat tccgctttct ttaatgacga 3144841 tctgatcctc gcgcggccgc atcacccgaa gaatccgctc catatcaaaa tggccgtagc 3144901 tgacgcccgt ataatatgcg tcgcgctgga ggtaatccat gcggtctgcg tcaatctgac 3144961 tcgaaatcag gctgaccact tgcttgtttt tatatgtttt ggcaatgact tcagcaacat 3145021 cctgagggaa acccgggctc acctttctga gcacctgatt aacctccgtg tctcccaaaa 3145081 tgatacctct tgtaaaatcc tcgtggtcaa ggtgaaagac cttttcaaat gaatgcgaga 3145141 acggcccgtg cccgaggtca tgaagcagcg ccgcggccaa acagagttcg cgctcactgt 3145201 catcccattc agggcggcct ttaaagacgt catcaaccat tcttctgaca atttcataga 3145261 caccgagaga atggttgaac cggctgtgct cagccccatg gaacgtcaaa taggtcgttc 3145321 cgagctgctt aattctgcgg agacgctgaa attcacgggt tccgatcaaa tcccatatca 3145381 gcttgtcccg aacatgaaca tagcggtgca ccggatcttt aaacactttt tcttctgata 3145441 attttccatt tggatacgcc atcgtcattc cctctttttt ttagccgtgt ttctattata 3145501 tcgactctat tctttgaaaa catccttgaa tttgcccggc gatttgttcc atcttcatga 3145561 aaaacacatc ttgtgaagca aaaaagcctg acctgagggc cgaggctaag aaaaaatatg 3145621 tttttacttt tttattttct tttttacttt gtcaatcagc tcatcctctg tcggagctga 3145681 cagcgggcga ttgttcacaa aagcaaatga ttttttccgt ccgggcccgc aataagattg 3145741 gcatcctacc tcaacctttg cgtccgggtc cacttctttc aaacgcggca gcaatgtttt 3145801 gatattagtg gcttggcaat catcacacac tcgaaattca ttagccatga cgtacgcttc 3145861 ccttcatttc tatgttcatc tatgtgaata acctaaaatc acgtttcaaa aaaaatcaca 3145921 tcacacttca ttttacaagg attcgactgt tcctgcaagc cgctccatcc ttcgtatctc 3145981 ctattctttc agccaatttg tataaatatt ttccaacctg gacattctaa taccatgaaa 3146041 agaaaaatgg gagttgagat aaatgacaaa acagcgacaa gacgcttggt cagaggaaaa 3146101 cgatctgctt ttagccgaaa cagtgcttcg gcatgtgagg gagggcagca ctcagctgaa 3146161 cgcctttgaa gaagtcggcg ataaattaaa ccggacatcc gcagcctgcg gattcagatg 3146221 gaacgcagtg gtccgccatc aatatgaaaa agcgcttcag cttgcgaaga aacaacgaaa 3146281 acagcggatg agagcgctcg gaaacgggca gcccgcgaaa aaaagattat tatatcagcc 3146341 tcctgccgtt gatcctgaaa tcattcaaga aaccgctgca gaagagccgg ttaaaacgga 3146401 aacaccatct gtcgaaaatg agcaaccttt aatgtctggc gaacacatgc cttttgttga 3146461 tgaaagcttt aaggaagagt tagctagtct atcacactta ttgtctcctc aaacgcctgc 3146521 agctgcgcct gagatgacga tgaatgatgt gatccgcttc ctgcagaatt acgaaggcaa 3146581 tcacgagcaa tcatcagcat taaaaatgga aaacgagcgt ttaaagaaag aaaatcagga 3146641 attgcaaaac aaaacagagc agctagaggc agaagttcaa aagcttgaaa aagaccaaaa 3146701 aacgatccaa gaagattatg aaaccttggt gaaaattatg aacagagcca gaaagctagt 3146761 tttatttgaa gaagatgaac atgcctctcc gtccttcaaa atggaccgga acggcaattt 3146821 agaaaaatta gcggaatgac atagaaaaat cccaaaacgg gcagctgttt tgggattttc 3146881 gccatgtgca aaatcccctt ttctattgag aaaagagaat ttcctcattt tgcagccgga 3146941 tcagctattc ttgtaaaatg aggccaagct tatgtgaatc tattaagaca tgtgagctgc 3147001 ctcggccgtt ttttgtttcc gaggcgcagc agaaatgacc aaaagcccca gcatcataag 3147061 cgcaatgccc agccacgagg aaggcgaaag catttcccct atgaaaaaca cgccaagcaa 3147121 tgaagccgtc agcggttcag ctaaagacag cgtgaccgcc gccgaggccg gaaccccggt 3147181 aagccctttc gcaaacaaaa agtatgcggc acatgttgca attaacccga tgtaaaggct 3147241 tgttcccagt cctctagggg tcaatatcca cgagatatct aactgccata atagcggcgt 3147301 cagcaagatg gcgctgatca tgaatacaac ggcggaggtc gctcgcggag gctgggtttt 3147361 catcatcgct ttactgatga gcgtatagcc tgcaaaagaa gcacccgctc caagcgccat 3147421 aagaacacca gccacatcaa tccgaacatt ggaactgtcg gaaaacagaa gccagcaacc 3147481 cgctaaagcc agcacagtcg caatccacca ggagtttcgc gggcgtttct tcaatacagc 3147541 ccattcgagg gtcccggcaa tgataggcgc actgccgatg gcaatcacag ttcccactgc 3147601 aattcccgtt tctttaaccg ctgtgaaaaa cagcggctgg taacacgcca tacaaacagc 3147661 ggctaaaaat acgagcggcc atgcccaatt tttcacgtga agctcccggc tgatccaaac 3147721 cgcaagcagc atggcgcttc ctcctattaa taacctgaac gctccaaatg ccagcggtgt 3147781 ggcgctttct ggagccaatg cctgaacggt tcccgtggtc ccccagaaaa aagccgcaat 3147841 caatacaaaa aggctgtaaa tattcccctt catctgcctc tcccctttaa tatggatgct 3147901 gatgtcattt tatcgttttt ctttttgtcg tggttatctg tatgtaagaa ggacttatct 3147961 gaaaataaga ttattgaggt aaaatgccgc ttgagataaa aaatgcatgc cggcatatac 3148021 agccggcatg cgaagaacgt tcacccaaat acctttgcat tccgctcagc catccggacg 3148081 aggtttttct caaattccat ttcctcatca atggacagtc cagctgaata aagatgggtg 3148141 cttaacgctt ttaattccgt caataaagcg aacattaagt cttgtacgga gatgtctttt 3148201 tgaagaagct cacttaagga cgccatcgtt tccggacgta tttccggata gacgcctttt 3148261 ttatcgtttt gtttgtcttt cagcgccgct tgatagaatc gtctgatcaa gtcggccctt 3148321 tcactgccgc ttttatctgc acagagataa atttgaacag cgactccgcc gcgaacgcgt 3148381 ctctgagaga tgccggcgaa ctttttgcca tttatactga ggtcatagct gccgggacaa 3148441 taagaccctt caatttcata ggcttcgatc tttgcgttgt acggtctcag cattcgtctc 3148501 atcagctcga ccatcgcttc atatcctttg tctatatcga tgcctttctt ttcgtcctcg 3148561 aatatgagag agatatttaa aacaccgtca tccaatacga cggcaagacc gccggaattg 3148621 cgtacgatca cacggtatcc ttcgctctcc agcaaggaga taccatcctg caaaaacggg 3148681 aggcgtgtat cctgtattcc aaggacaatt gtatcgtggt gcacccatga gcgcgctgtc 3148741 gccggcgaca cgccttttcc gacggacatg catagcgtat catccattgc gaaggattgc 3148801 ttcgcatcaa ataaagggcc gagactggat tggtcaatga ctctccattt cggctgcatc 3148861 agtaaatcaa tcggttggtt tgccatctat gtaaaaccct ttcatgttag gcttattgaa 3148921 cgaaaactat tatatcattt cagcagctgt gattgataat tgcttttcag catcgtaata 3148981 aaaatttctt tattttttgt attctccatg agaggagaat gaatgtaaga cagcttgcgc 3149041 tttaacgaga aattattaat atgcagaatt gaaatttcgc ggtggatcaa atccttacgc 3149101 agcacgcttc tggatagaac cgaaagtccc atgccgttaa tcaccgcttc ctttacacct 3149161 tgattgctgc tgatggtaaa cattgatttc ggccgaagtc catttgaact gagtacatga 3149221 tcgagatatt ctctcgtccc ggagcctttc tctcttgtca cccacgcttc gttctgcaaa 3149281 tcgctgatcg aaatctcttt ccgcccggcg agcggatgct gatttggagc ggcaatgcac 3149341 atttcatcct ccatgaacgg ttcaatttcc agctcattct cgtttgtatg tccttcaatc 3149401 agcccgatat cagcctgaag catccgcaca cgctcgctga cctcctctgt attgccaatc 3149461 atgacatcta gattcagctc tggatacagc ttttgcagct gggccaatag cggcggaaga 3149521 atatactcac cgattgtaaa gcttgcagct attttcaatt cacccttcac atagtgatga 3149581 tgcgcataga tttcagcctt ggcttgttcg tagagaaaca ccatttgctt tgctctttga 3149641 tataaaatgt ctcctgtcgg cgttgtcgta aagtgttttg gcgacctgtt cagaagagcc 3149701 gtttgaaatt ctttctcaag atttttgata tgcagactga cgctgggctg ggagatcatc 3149761 agcttttccg ccgcttttgt gaagtttttt tcttctacca ccgctataaa cgttttcagc 3149821 acgtcgtaat acaaaaaccc cacccctgtc attaatgaaa tatatggtta tgattagttt 3149881 tctttattgt actcatatca tccgtcttgg taaagaaggg ctatacagaa gcgcaaaaaa 3149941 ggcagccctc ggtcgagagc tgccattgtc ttcaatttta ttacagtgct tgcgccgctg 3150001 taattaatgc gagattgtaa acatcttcag cgttacatcc tcttgaaagg tcgtttacag 3150061 gcatatttaa accttgcagg attggtccta ccgcttcaaa gttgcccaaa cgctgagcga 3150121 ttttatagcc gatgtttcct gcttcaagac ttgggaatac gaatacgtta gcgtcccctt 3150181 tgatctcgga atccggcgct tttttctcag ctacagatgg aacaaatgca gcatcaaatt 3150241 ggaattcgcc gtcaagtgtc agttcaggcg ctttttcttt cgcgattttc actgcatccg 3150301 ctactttttc tgtttcatca gattttgctg agccttttgt agagaagctg agcattgcca 3150361 cgcgaggctc aatgtcgaac atttttgccg tattggcact ttcgatcgca atctcggcaa 3150421 gatcttggct gtcaggtgca atgttgatcg cgcaatctgc gaatacgtat tgctcttctc 3150481 cgcgagccat gatgaacacg cctgaagtct ttttcacgcc ttcttttgtt ttgatgattt 3150541 gaagagccgg gcggacagtg tcagcagttg agtgagcagc tccgcttaca agtccgtctg 3150601 caagtccttt atacaccagc attgtaccga agtagttctc gtctaataat gctttacgag 3150661 cctgttcttc agtcgctttg cctttgcggc gttctacgaa tgcttgtaca aggtcttcca 3150721 tgccttcata tgtatgagga tcataaatct taacgccgcc cagcgtaagg ttcaattctt 3150781 ttgcttttgc ttggatctca ttttcattgc cgatcacaat cggattcagc actttgtttc 3150841 ctgcaagctt gctgaccgct tctaaaatac gctcgtctaa gccttcagga aatacaattt 3150901 taacgtcttt tccagctact ttttcttgca ctgttgaaaa taaatctgcc acaataaaac 3150961 ctcctcaaaa agttacaaaa acgctttctt ttactagcat actcttcttc caatcaaatt 3151021 caaacagcca actttcatta tagcgctttc ataaaaaaat cttatttttc taactaattt 3151081 aagtgactca atcttccctt ataggttctt ctattttgat ggagttatac ggaagggatg 3151141 ttcaaggttt ctccacagta gaatcggata aactatggta tagtgaaggc aatcatgaaa 3151201 agataatggg agtgaagata aatgagtgaa cagcaaatga cgaatgaagc ggcaaaaacg 3151261 cttgacggct ggtatgcgct tcatgatttc cgcacaatgg attgggcttc ctggaagctt 3151321 ctgtccagtg atgagcgcca atctatcata catgaattca ccgggttgct tgaaaaatgg 3151381 ggcgtagccc aaaaagaagg aaaaggatcg caaactcttt acagcatcgt cggccaaaaa 3151441 gctgatttta tgctgatgat ccttcgtcct acaatggaag aattaaatca aattgagctt 3151501 gaattcaaca aatcaagact tgctgagttc accattccgg catactccta cgtatcagtg 3151561 gtagagctga gcaactactt ggcaagcggt gacggcgatc cttatgaaaa tccgcatgtg 3151621 cgcgctcgcc tttaccctga actgccggaa tctaaatatg tatgcttcta tccaatggat 3151681 aaaagaagat ctggcaacga caactggtat atgctttcaa tggaagaacg cagaaacttg 3151741 atgagaagcc acggtttaat cggccgcagc tatgcgggca aagtcaaaca gatcatcacc 3151801 ggctctgtcg gctttgacga ttacgagtgg ggcgttacat tatttagcga tgatgtcctt 3151861 caattcaaga agctagtgta cgaaatgcgt tttgacgaag tcagcgctcg ctatggcgaa 3151921 tttggttcat tctttgtcgg caatcacctt tcgcttgata cacttcctca attcttatat 3151981 gtataatatc cccgagctcg tttattgaga taaggactga tcggccttct gctcaagttt 3152041 gccgtacttt ttatatgcga atacactgag cacaaatccg aggactgtga tggcggcgca 3152101 aatcaatccg acagctgcat agccgtatgc cacatatacg ggtcccatta aagcagaacc 3152161 taatgtcacg gccagattcg aggcgagact gtaaaacacc atgacttttc ctcgatgacg 3152221 ctctgagcag tcactcaaaa tggtgctgag cagcgtcacc gtcaaacttt gcattaatcc 3152281 ccaaataaat aggctggcga ttaacagaaa catagacgcc ggcgcatatg gtaaacacgc 3152341 cagcagaacg ctgatgaccc ccagcgcaat caaaagggag cgcatttttc cgatgcggtc 3152401 ggctatcttt cctgtaatca cactcatgga aaacccgatt ccataaatca tgataaataa 3152461 gcccgcagcc gtgtttcctc cggtaaaaac gtcctgaaga taggtgccta aaaaggaata 3152521 cataccgtaa aaaccaatca tattacaaaa ggttattgtg atataaacag gtacacgagg 3152581 gactttcagc gcatcccgga atgttcctgc gggctcttct atttcttcct tgccgctgtt 3152641 tttatgttgg gcatggcggc gcatttcaag gagaatcagc agaacaacta aaacacccat 3152701 cagggcgaaa atccaaaacg tccatctcca atgcaggacg ccgccgataa atgatccgag 3152761 cggcactccg aaaatcagcg ccagcgacca gcttgaaacg atcagtccca tcaccttgcc 3152821 ccggtatgta taaggaacac gatcaccgac aactgcgtaa gcggtcggaa caaacgctcc 3152881 cgcagccaat cccgaaagcg cccggcctaa aaagaagaaa aaaatatttt gagctaaagc 3152941 gcatatcacc gttcctatga taaaaatcat aagcccggcc aataagctca gttctctgga 3153001 gtatttatcg cctaatggaa ccaaaagcgg cgcaccgata aaaatcataa cgccgtaaat 3153061 actgatagat aacgcaagga cgctgacatc tgagctgaag gcttttgcta aatccggcag 3153121 cagcggtgag atcacaagct cttcagatcc ggctgcaaat acccccatcg ttaaagccag 3153181 tgccaacaat aacggaaaat gatgttttgt tttgatgtca ttgttttgat tgctgttcat 3153241 tctttctcaa acacctcttc cataatcttc ttatcataaa gttgtattat agtttagcat 3153301 tgttttttct ctatttacaa ttcgaacgaa atatttataa gttttattat tttcatttaa 3153361 atcccattat atatttctat atttcattct aaaaatacat gaggatgtaa cacgtaaaaa 3153421 aagctctccg gcctcccgga gagctttttc tattgcgcct ctgtctgctt tttttcaatc 3153481 gtttcatgat ttatacgctt tttgatgctt agatgatagt atgcataaca gaaaataatg 3153541 atcggcacac cgcagtataa gccaattctt tgatccggaa tgaaaataag gctgatcaac 3153601 acgcagccat ataaacaaaa tccgagaatc gggactagcg gataaagcgg cgttctgaac 3153661 tccagatcat tcacatttcc gccttctgcc aggaaacgcc tgcgaaagaa aaattgcgac 3153721 gcacaaatgg acatccacgc gacaactgtc accatgcccg agattgagat acaccataaa 3153781 tacactgttt ctgcagccat gacacttgtc agcagcgaac agcctgaaat gcctagcgta 3153841 atcagcaggg cattcatcgg cacgcctttt tttgtcagtc tggtgagaaa ggagggaccc 3153901 atttgatttg atgaaagtga ccacatcata cgcgacgccg catacaatcc cgaattagca 3153961 acagataaaa tggccgttaa gatgacaaag ttcatgatat ctgccgaaaa tgggatgccg 3154021 atttgatcga gtactgctac aaacgggctt tcaatcaccc ccgccgtttt gtacggaagg 3154081 atggcaacca agacgaacat agcgagcaca aagaaaaaca gcgtgcgcca aataacattt 3154141 cgaatggact ttggcagtgt tttttccggg ctttcacttt cccctgccgc aatgccgaca 3154201 agctccgttc cctggaacga gaagtttacc atgaccagcg taaacataac ggccagcacc 3154261 ccattaggga aaagccctct atcagtcata aagttagaca aaaagggtgt ctcctgtccg 3154321 cctttaaagt caatcaagcc aaacacagcg gctccgccaa tcacaataaa taatatgatc 3154381 gccgccactt tgatgcttga aaaccaaaat tccatttccg caaagcttct gacagagagc 3154441 gcattaatca aaaagatgac gatgccgaac acgaggcacc atatccagat cggaacggag 3154501 ggcagccacc tttgcatcaa aatgcctgct gacgtcagct ctaaccctac tgtattggcc 3154561 cagctgaacc aatacagcca gccaatcata aagcctgtcg actgtcccag aaatttagtg 3154621 gcgtaggcct gaaacgatcc ggccaccggc atggcaacag ccaattctcc taaacaaagc 3154681 atgacgagat acattaaaaa tccgccgatg atatacgcgg caatggcgcc gagcggtccc 3154741 gcctggctaa tggtaaagcc agagcctaga aacagcccag tgccaatcac ccctcccaaa 3154801 gcaatcataa acaaatgcct gcttttcatg ctgcgctgca attcattttt atgattctgc 3154861 atcatccttc cccctttggt tcttttgccg tgatggtcat ccggtagctt tgcaaaagat 3154921 gaacggtggt ttgctgtatg aggagaggca atacatgaaa tgtgtacggt ttatagactc 3154981 gttctgtcca tttatggccg tcttttccgt acacgcccat attaatggat ggaatattca 3155041 gcttgcgtat gtctttgaac ggaatggtcc caatcatatt ccacccaggg aagttcctga 3155101 taaaagaatc aatttcgcca tcggtttcgt gcagtgataa aaaactgccg tctgccaagt 3155161 aggggaaaaa ctttttgaag acaaatgttt cgcctgtcga ttcagcggtt ttgtcagccg 3155221 cttctttaat cacatgctgc aaaagctgat ctcttgcgct atcttctttc aaatagttat 3155281 gcggcaggta aggaggtgcg taaaatagaa tgacttttgc gccttgatcg gggtcaagct 3155341 tttgaagctc ttcgattgcc tgaaagcatc tcatgcgaag ttcaaggtgc tcgttggctt 3155401 tgaatgtctg ctcgatacac tgctcgggat ctattccccg gtttctcagc ttttctaagt 3155461 attgctccag gctatacact tgaatgcccc atgataaatg tttctttggc aggttggctc 3155521 tttttacata ttcttcgtaa taatctgata atttttgttc tgtctcccgg catgcttcct 3155581 cagtgacttc aataagcaaa tccatcattt cttttgctgt tctttcataa ataaaacaat 3155641 tgaaatacaa gctggtgctg acagccgttt gcacattata ggattccttg ttatcacgct 3155701 gatacaaaca ggatgggggc agaaccaact ccccttcaac cttttctgcc agatggatgt 3155761 tattgtggag acggcttgtg atttcagatg aaatgaaatt tgggtcaatc cctgccagtg 3155821 tatcgccaac atggacttca cgcccgtaaa tgtaaaagca aggcaacagt tttcccgcgg 3155881 ctccggtata gatatatctt gtctgatcac catcgtaaag cggggtaata aaatccgtat 3155941 taatagcagc caaatagtga agctgttttt ctttttttag ccggttcagc tctgaaatgc 3156001 tggcgagaat gcccgaatgc tggctctcct catcgggatt ggccataaac aatacatttc 3156061 ccggcaacgt ctcaaggttc tccgaaaaat gcaggagatt ggctaaatgc acggcgatgc 3156121 cgctttgcat atcgacagat cctcttccga acatccactc gcctgatttg gcatcccgct 3156181 gaacatcctg atcgaactca tagcggctga aatactcggc caatttctca caatcaaaag 3156241 cgatatcctt taaagggccg aaatcttcaa ttccaactgt atccagatgg gcatggtaaa 3156301 tgactgtatt tcggctttct ccatgtcctt taataaacgc aaaaatattt ttgcgtttgt 3156361 atgggtcatt gggaatggcc tgttcccaca catgactggg gttttcctga aaataaggat 3156421 agctcgtgat cacttctttg atgaaatctg cttttgtccc ttctccaacg gtgccgttca 3156481 cgctgctgag gctgaccaga gatgctgtca gcgcctccac tctttcagcc ggattcatgt 3156541 gactgatttt tgtatactgc ataaattgtc ctcctgatca aaaagttgaa atcgtgcgat 3156601 ccgctaaaga atcgcacgat tttatttctc tcaaatcaaa aagcttcgga cgttgttttg 3156661 gcttgcatat gaagaattaa gtaatcggga ccgcctgctt ttgagtctgt tcctgacata 3156721 ttaaaaccgc cgaacggctg atagccgaca attgctccgg tacatcctct gttaaaatat 3156781 aggtttccga catggaaatc ctcgcgcgcc cgttcaatgt gcgcacggtt tttcgtcaga 3156841 agcgcacctg ttaatccgta ttccgtgtta ttggcaatct ccagcatatg atcgaaatca 3156901 cgcgctttgc aaatcgcaac aaccgggccg aaaatttctt cctgcatcaa gcgggcgttt 3156961 tcatcaacat ctgcaaagat cgtcggctga ataaagtagc cttttgaatc atcgccttct 3157021 ccgccggcca atagcttgcc ttcagatttg ccgatttcaa tgtatttcat cactttgttg 3157081 taggatgctt catgaatcac gggacccata tacgtatcag gatcttctgg attgccgaca 3157141 gtcagcgttt tggtcagcgc cacagctttt tccaccactt catcatacac atcctgatga 3157201 atgaccgcgc gggagcccgc agaacacttc tgtcctgaat atccaaatgc tgaatacacg 3157261 atagaggatg cagcaaggtc aagatcagcg tccttgtcga caagcactgt gtcttttccg 3157321 cccatttctg caattacccg tttgagccat ttttggcccg gctgcacttt ggcagctcgc 3157381 tcataaatcc ggcagccgac tgcacgggaa cctgtaaatg agacaaaccg tgtcttcgga 3157441 tgctcaacta agaaatcacc gatctccgca ccatctcccg gaatgtaatt cagaacgccg 3157501 tttggcagac ccgcttcctc catgacctcg acaaattttg ctgccactac cggggctgcg 3157561 tcagccggtt ttaagagaat cgtatttcct gtcacaatcg ctgccaccgc tgttcccgcc 3157621 ataatcgcga gcgggaagtt aaatggagaa atgacgatgc cgacgccaag cgcttcgtaa 3157681 tgatattgat tgacctcgcc agcacggctc ttcaccggag ccccttcctt gagctttaac 3157741 atttggcgcg cgtagaactc taaaaagtct atcgcttcag ccgtgtccgc atctgcttcc 3157801 ttccacggtt ttcctgcttc cttcacaaga tagcttgaaa attcatgctt tcttctgcgc 3157861 aaaatagccg ctgccttaaa gagaatattt gcgcggtgct ccggtctttg ttttttccag 3157921 gaatcaaatg cctgcaatgc ggcttgcatc gctttttcag caagctcttg atccgctgta 3157981 gacgcgtacc caatgatctc ttctttattt gccgggttaa tagaaatgat tttgcggtcc 3158041 gtttcaattt tttctccatt tatgacaagc ggataatgct tgccgagctg agtgtttaca 3158101 aaggccaatg actccccaaa tgcagtttta ttctttgctt ccgtaaaatc ggtaaatggt 3158161 tcgtgcgcgt atgtgactgt catatgtagt ccccctcgtg ttatgaaata tatcttcgca 3158221 tatgaataaa aatgcaagaa tcatgccatt ttcttgtctt ttgctgaaaa aacttgttga 3158281 atcgaacaga aatttgtcta acaggtgatc acctttctct ttttccgatc ttgaacgcaa 3158341 atttattttg cgttttttgc tctttacgca aaaaacaaat gcaaaattat tttgcggagg 3158401 cttctcaaat tagacccatc cgcggaaacg cgatgcttct gccgattttc tgatgcccgt 3158461 catgtaagcc gccaaacgca tatccacttt atgtgttgcc gctgtttgat aaattgtttc 3158521 gaacgagctg accatgacgc ttctcagttt ttctgcaacc tcttcttccg accaataata 3158581 tccttggttg ttttgcaccc attcaaaata agaaaccgtg acgccgccgg cactcgctag 3158641 gatatccggc acaagcagca cgcctctttc attcaggatc ttagtggcat caatggttgt 3158701 cgggccgttc gccgcttcaa cgacgattga cgcctgaatg ttatgtgcgt ttttggctgt 3158761 gatttgattg gagatcgcgg caggcactaa aatatcgcaa tccttttcaa gcagctcctc 3158821 atttgtgatg acgtcagtaa ataaattggt gaccatacca aagctgtccc gtttatcgag 3158881 caaataaggg atatcaaggc cgtctgggtt gtagagcccg ccattggcat cagaaatccc 3158941 gatcaccttc gcgcccgcat cgtgcatgaa tttggccagg aagctacccg cgtttccaaa 3159001 gccctgtatg atgatgcgcg cgttttgcag cttgatccct tttttcttca ccgcctcttc 3159061 aatacaaatc gtgacgccct gtgccgtcgc tgtttcccgt ccttgcgatc ctcccaaaac 3159121 aagcggttta cctgtaataa agcccggaga atcgaattcc cgcagccggc tgtactcatc 3159181 catcatccac gccataatct gcgaattggt gtacacatcg ggagctggaa tatcctttgt 3159241 cggaccgacg atctggctga tggcacggac ataccccctg ctcagccttt ccagttctcc 3159301 aaatgacatt gtccgcggat cacaaataat accgcccttc ccgccgccgt aaggaagatt 3159361 ggcaatcccg catttgagcg tcatccaaat ggataatgcc tttacttcct cttcattaac 3159421 ttctggatgg aagcgaacgc ccccctttgt cggaccgaca gcatcattgt gctgtgaccg 3159481 gtagcctgtg aacactttga cgctcccatt gtccattttg accggaatgc ggacagtgag 3159541 cattctctgc ggctctttca tgagttcata catatctccc ggataaccca gcttccgaag 3159601 ggcttcctta atgattgttt gggtagacag aaataagtta agagcttctt tttcttcatc 3159661 tttcgagact tgctttgctg acatcttttt cacctcattg tttttttggc cggctgtaat 3159721 gtaagcgctt taaaaaatca gcccgccaat tcctttcttc attggattca cccttatcat 3159781 catgcaagat ccgtaccagc ttttgaatcc acaaaaaaag agactgaaaa catctcagtc 3159841 tctgactaca aatctatcga ttaacgggga tcaatcacca gctgcgtttc agcataaaaa 3159901 ctgccgattc ccaaaccgtt tactacatcg cctttaatcg tgtaagtgcc tgcgcgagga 3159961 agagttttac gcaccatgac aaggtcaaat tcggatgcgc ctaacaaatc aagcgtaagc 3160021 gggagtctga ctgtttttcc atcgtttaaa atctgtgttt ctttcagtgt tcttccattc 3160081 actgaatctc ttgtcgtagc atgaaacccg tcaggaaatt gaaattctac cgctccaaga 3160141 gaaagcaccg catttggttt atatgtcact tcaatatcag aaatggtcca ctctttcgtg 3160201 ctgttaactg tttttgcctc gattgatgca gactgtgcat gagcttggcc cgaaggaagt 3160261 aagattgata gtaaaacagc tgaactgatg aataatgaag atacgaatga agttcttttt 3160321 agcatgacat ttccccctaa ttgattgttg aaatttggcc agagcgtcct ctgcagaaaa 3160381 agcgcttttt cataattcgc gaattaccag ttctttttct taaaaattaa tctatcatca 3160441 ttttccatgg aagtaaatgt tttttaagga atattaacac ttggaattca atgagaattc 3160501 cttcctgttt atacaaggtt caaatggacg atttccctct ctttttctag taacatctgc 3160561 ctgacatttt atatctttta tcctatttta aaaaagggca aaaaaagtcg aagatgcctc 3160621 tgctcttcga ttgatcacgt tcctattttt atctgaattc agtgttccag ttaaaaccga 3160681 tcgtctcatc atcccacgga attctttttt catcaggctg atccgggtta tacgacatgg 3160741 tggtaaaata gataattgtc agcggcgtct ctcccagcac tctatatccg tgagccaccc 3160801 cttttgggat taataacagc atcgggttgt cttcgcccat ataatagacg tccgtttctc 3160861 cttttgtctt tgaatcctct cgaagatcgt ataggacaac ctgagcgtgg ccggttggga 3160921 agaaccagag atcatcctgc ttctcatgat aatgaaatgc cttaatcaca cccggatagc 3160981 ttttcgacca agaggcctgc ccaaaatgct caaggagatt ctcatcgtcc cggaccagct 3161041 cagcaaaaaa gcctctgtca tcgctatgct tcatcaattt tttcaccttg actccatcaa 3161101 tcacacgcac tgctcctttc ctgcaaatac tctcgtaacg cttcccgcca gtggcggggg 3161161 cggatgccgg cttcttcaat agcccgatgg ctcagcacag agtatgccgg acggggcgtt 3161221 ttgttcccgt attcctctgt cgttacagac aaaatggctg tttccagccc gctttcttcc 3161281 ataattgccg tcgcaaactc ataccagctg catatgcctg aattgctgac atgatagatg 3161341 cccggcggat ggctgaacag cttgatgacc gcttctgcta aatccttcgt ataagtcggc 3161401 gaaccaattt gatcgctgac aacccgaagc tcttgtttcg tttcagcaag tttcagcatg 3161461 gtttcaacga aattactgcc gccatgtccg tacacccacg atgtcctgat gatcgtgctg 3161521 tcttttgtcg ttaatcgtat cagttcttct ccgagccttt tgcttttgcc ataaatggtt 3161581 ttcggatcga ggggatcgtc ttccctatat ggctgggttc ctttcccatt gaatacatag 3161641 tccgtgctga tatgaacata ttgagctccg atgcgggttg actcaagcgc tgtataataa 3161701 gcgccgattc cgttaatcaa gtacgcttta tcaagctctt tctcgcattg atcaaccgac 3161761 gtaaacgcgg cgctattgac cacgatatcc ggctgataat ggccaaacga atgccgtact 3161821 gagcgctggt cagcaatgtt catcatcttc tttgttaacg caatgacctc atatccggct 3161881 tgcttcagct ggcggcatag ttccaagcca agctgtcctc ccgccccagt caccaatacc 3161941 tttgtcaatc agatcacctt ctcatcggtc attgtctgta taccactgaa tcgtacgcgc 3162001 aatgccttct tcaaacgtca cttcctgccg ccagcccagt tcgtttttca gctttgatgc 3162061 attgatcgca tagcgccggt catgcccttt tcggtcttcc acgtgggcga acaattcctc 3162121 acagcccaga tgcttcaaaa tgacactcgc cagctcttta ttcgtgcgtt catttccgcc 3162181 gccgatgtta tacacctcgc cgtcggtccc tttttctaaa atcagcttga tcgcgcggca 3162241 atgatcctcc gcaaacagcc agtctcggat ctggagtcca tcgccataca gcggaacagg 3162301 caggccctgc ttcgcatgac ggataatcgt cggaatcatt ttttcgctgt gctgataagg 3162361 tccgtaattg ttgctgcatc gtgtaatgat ggccggaagc ttgtgggttt tcacataaga 3162421 caacacgagc aaatcagagc ttgctttgct ggctgagtat gggttattag gagaaagcgg 3162481 cgtcgtttct gtaaacgcgg gatcatccgc ttttaaatcc ccgtatacct catctgttga 3162541 aatatgaatc agcttcttgg cttttccttt caagaccgct tccgccaatc ggtatgtccc 3162601 catgacattt gtggtgataa acggctccgc ttgggaaatg cttctgtcca catgcgattc 3162661 tgctgcgaag tgaatgacgc catcgtaggt ctcgtcaaaa gcgcggtcga tatcctcctg 3162721 aacgctgatg tcccctttta caaagcgaaa acggctgttt tgctttaatt tttccatttc 3162781 ctccgggtgg ctggcgtacg tcagtttatc taaaacggta atgcgcgcat ccgtttccct 3162841 cagcatgagc tttgtaaacg tgagcccgat gaagccggcc ccgcctgtaa ttaaatatga 3162901 ttttgccatc acttttcgtc ctgtcctttc cgtaaagcct ggtgtacaag ctgggaagcg 3162961 agataaagcg attcgtgagt tccggcatct acccaccagc ctgataacac atcatacgta 3163021 agctggctgt tttcgatgta tagattattc acatcggtga tttccagctc gccgcgcttt 3163081 gatggtgata tttgttcaat atatgaaaac acctctgcat catacatata aatgccggta 3163141 acacaaaggt tggtcggtgg ctgttcgggc ttttcgatga tggaacgaat ccgcttgttt 3163201 ttctcatcaa tctcagcaat cccgaaacgt tccgggtcat caacttcttt cagaagcact 3163261 tttgctcctt tcccctgctg ttcaaagcgt tctgtataag gctttaatga atcttcaaat 3163321 atattatcac ctaataataa aatgaaagac tcttttttcg taaagcgctt tgcataagac 3163381 agcccatccg aaatgcccga tgctgccggc tgtacttgat aagtgatagt aacgccaagc 3163441 tcttccccgt tcccaagcag tttgtaaaat tgcggcatat gctccttttg gctgatgagt 3163501 aaaatgtctt ttattccggc ttcctgcagc ttcataatcg accagtatat catcggatac 3163561 gggcctacag gaagcaaatg cttgttgacg gctttcgtta agggcataag gcgtgagccg 3163621 tttcctccgg ctaaaataac acctttcaca ttaacacttc cttacatgca tttttatatc 3163681 tcttgttcat ataaatcttg aagaatagct gttacccgta taatgccttt gccatccacg 3163741 agcggccttc ctcccttgtg caaagaaagg cgaagaggat agctgctcat aatgcgtgac 3163801 atctgataga tgagtgtttc atccggtaca agctcaccca atccaagatc aagagcggcg 3163861 ccttggtcag caaatgtttt ggctgtagcc gtttgatgct caacctgaga aagaacaagg 3163921 cacggcacgc cgatgcaaat ggcttcatat agagagatgc cgccagcgac aatggctgcg 3163981 tccgcttgtt tcatcaaacc tgccatatca tttgtctgtt cgatcatctt gtactgcggc 3164041 ttcttttcga tccgccttcg gactgcctct tgatgcggtg aagcgctccc catcacaaac 3164101 atcatgtttt tgtcttttat gtcggggact tgatcagcgg cagccagcac tttaaaaata 3164161 agctgcttcg gatcacttcc tcctaatgca acaaggatat tgcggcagtc tttcttaagt 3164221 gtgtaatcct ctcttgcggc ctgaaaggcg gggtgaagaa taagatagtc cggaccttca 3164281 tagatgcgtg tgtttccctg aacgtacacc ctgcttctga tgtcaccgta aattccgtta 3164341 atgactgcgt cactatattg aatcgattta ccgtttttct cttcaaaaag aacaattttc 3164401 gcatctgtct ccgtctttat tttctttaac agctctgcag gcgcgcctag aatatcaaac 3164461 aaaagcaaat caagcttctt gctttttatt tcccggagaa taaattcgtg ctgctgcagc 3164521 tccggcttta cgatgacctg ccaatgctct tcatgaagaa acgcttcaga atcctgattc 3164581 gtataaaacg taatcaagca tcgctgtttg agcccctccg caagcctctt catccggaca 3164641 acatggccca ttcccttttc atagccgccg tctgcgaaga tcccaacatg catggctagt 3164701 cagcctctcg ttcggttgcc gcatcggggt tccggttcag aagggtgata agctctgagg 3164761 cggatacatc ggggcgctcg cctgcttttt gatagagggc ctttatcgat tcatagtctt 3164821 cctttgtatc aatggtcagc cgatattgag gggcgcgaaa tcgttccggc gcctctaaaa 3164881 actgaacacg ataaagagct ggatgattcc ttatatataa cgtgacatgc tcctgatatt 3164941 gatcctccaa agcctgaata cggctgatgt caattaacag gttggcgttg accacttcgc 3165001 cgcaaatccc taatggggca ttcaggatat acgtataatc cgagccttga tcaaaatgcg 3165061 cctgaatcat tacatcgagc agctcaggat cgacaaacgg attatcacct gttaaccgga 3165121 tgatgactga cggtttaaca gcttctatga ccttcacaaa cctatcgagg acacgttctt 3165181 cgctcccgcg gaaaacacga aagccttgtt tgatacagtg cgcctctaat atgtcgtcag 3165241 tttctttgtc agacgtggcg atgacaagat tatcccgatc cttttggtaa aacgcgcttt 3165301 gccggacacg gtgaacgaga atatcaagta aacgattcga tccgagcggc cgaagcactt 3165361 ttcccggaag ccttgttgaa cccattcttg cttgaatgat aaagagaata tcattcatga 3165421 aacgggctgt ccttcagtaa aatgtcatcc cagacaatgc ctgtgtcggc tggaatgtct 3165481 cttacagccc gaacaccgct ggtcagcagt tcaaaaaatc tcgggtgcag cccctgcggc 3165541 ttttgtccgg gccgaagcac tgcgatattg tcttcactaa aggcttcacc tttttgaatc 3165601 ggagctgttg taaaaatgcc tctgtatgca aagtttctga tttctccttc gatggcggtc 3165661 gttgttttgt atgaactgcc aagcagtttt tcagagaccg gctttgtgat cccctgtttc 3165721 agctcagctt ccgttttcct gatgccatcg accatttctt tcaattcatc cggatttaat 3165781 gcaaacgagt ggtcagcacc cggcagattt ttatcgatcg taaaatgctt ttctatcagt 3165841 tttgctccga gccgaaccgc ggcacacggc gcttctgtcg gatgctcgct atgatcggag 3165901 aagccgatta ccgcctcagg aaaagcggcg gcaagcatcg gaatgacgct gaggttgctg 3165961 tactccggcg gtgctgggta tttcgccaca caatgcatta tggcaatttg attgtttccc 3166021 tctgccctga tggtgcgcca agcttcgtga acatcagaga tttcagctcc ggctgtcgag 3166081 aaaatcatcg gcctgttcag ccgggcgaca tatttaagca gcgggagatg gttaatttca 3166141 taggatgcga ttttaaaagc gctcggcgag gtagactgaa gcagatcagc tgacccctcg 3166201 tcacataccg tacttaaaaa gatcacctgc ttttcgcggc agtaatccaa tagcggtaaa 3166261 atccactcag caggcatttc catagattga accaaagaaa aaatagagac gtccttgccc 3166321 gctgccgtct tgtacaaacc aggatctttc tggtacatcc tatcagcttg gaacatttga 3166381 aatttcacgg catccgctcc cgcttccgcc gcggcgtcta tcagcgcaaa agcctgatca 3166441 agcttcccgt catgattaat ccccgcctca gcaataataa aaacaggagc gtctttgcct 3166501 acagttttat tcgcgatctg aaacgctgcc attatttcgc ctccttgccc ggccaaatat 3166561 gataatagta atacgattgt tcagcggtga agcccattcg ttcataaagg cggatcgccc 3166621 ttacattgtg aagctgcgtc cccgctgtta ccgttctatg cttctgggtc tccggttgtt 3166681 ctatgagatt cgccaataaa tgaaacgcaa tacgtttccc ttcaaatccc ggctttacag 3166741 ccatcaaatc gagaatgcac tcatcatctc ttgataagcc ctgaagatag ccgatgacct 3166801 cgccattgtg tttagcgaca atattgaccg ccgcccttcc attcagattg tttcgtgtcc 3166861 actcctgaaa tatttcgttt gctgcatcgc ggctgagatg aggatcctga aaatatctgc 3166921 tttttgtaaa cgagtctcgg gccagctcac atatcgcttc tgtgtctccg ggctcaggcg 3166981 ggcccagttc aaaaaatggc ggtgttttgt cataaaaaga cggaggcatc gccagcttca 3167041 gcaaactccc gacaaagtaa gaggatggct gctgttgtat cacatgcgcg gctccgatat 3167101 cttcagccgg aacacggaca aagataaaat ccgtttcatc catttggcgt acagtataaa 3167161 aagcttcaaa cagcctcttt agctgcccgg tactatttgc cgcaagaagt ttgacgttca 3167221 tgactttctt ctgaagcacc ttgctttccc acaaagaatc ttcgtaaagc aatacgcctt 3167281 ggagcctgct gttttcaaaa aggccgaggg aaaattgata cggaacatcc aatgtaagct 3167341 ttctgctttg gagaaattcc tcaattgcct ctttggagac attttctttt accgtataca 3167401 cttaatcagc cccttttacg atatcccgca cagcttcaat gacatcatct acatcatcgt 3167461 cagacattga tggatagagc gggagagaaa gggttcgttt atagtaattc atggcattcg 3167521 gaaagtccgc ttccttatat ccaaattgct tttgataata cggatgaatg tgtactggaa 3167581 taaaatgaac gctagtgccg atattgtatt catcctttaa agccgtaatc atttcgctgc 3167641 gcgtaacccc ggcctttttt tcatcaactt gcagaacata tagatgccag gcgtgcctgc 3167701 cgtcatcatg gacaaacggc gtgatcagcc caggaatctg ctgaaaagcg gtttgatagc 3167761 ggccggcaat ctcttctctc cgtttctgca tatcatccag ccgtttcagc tgatgaagtc 3167821 cgagggccgc ctgcaaatca aacatattca tcttatagcc gggcgattcg acttcatagt 3167881 accagctgcc atttgaagaa taacggttcc atgcggcttt actcatgccg tgaaggctta 3167941 gcacccgtat cttatcggca agctcctcat catcagtcgt cagcatgccg ccttcccctg 3168001 tcgcgaggtt tttggtggcg taaaagctga atgccgttgc atccccgata gaaccgatca 3168061 ttctttgctt ataagtcgta tataccgcat gtgccgcatc ctccagcacg aataaaccat 3168121 gattttgggc aacagccaat attgcatcca tatcgcagga ctgcccgcca aagtggacgg 3168181 gcacaactgc tttcgttcgc ggtgtgacgg ccgcctcaag ctttaccggg tcaatattga 3168241 gcgtgttttc gtcaatatcc gcaaacacag gcgtcgctcc cgtatgaata atcgtattgg 3168301 cggtcgagct gaacgtaagc ggagaggtaa tgacctcgtc cccgggccca atcccttttg 3168361 ctttcaaagc caaaaataaa gctgcggtac atgaattcac cgccacggcg tgcttcgccc 3168421 cgacaaacgc ggcaaactct ttttcaaact gctgaacctt cgggccttta gagagccatc 3168481 ccgattcaag cgtttctgta acctcctgaa tttcttcctt accgattaac ggcaatgagt 3168541 aagggagaaa atgatttctc ttttgcacca tttctttgcg ctcctatcat tttattcagt 3168601 atcttcccgc ctgtaatcaa cccctgtttt ggctttcagt tccgcaaata aagcatttgt 3168661 tgattctgcc accggataat tagccgctat gaatgccagg cgcgcctctt ctgctttttg 3168721 atgcacgtcg ggacttcgaa gaacctcaac caaggtgtgc gccagttcat ccggctggtc 3168781 aaacataaaa tcgccaagag actcataata cggatacgag cgatttccgg acgattttcc 3168841 tatcagcaca ggcttttgaa acagcatggc ttcaagaccg actgtcgagg tttgcgtcac 3168901 tgcggcatca acatacggca gcaaatcata aagctccagc tcctttttga tgactctgca 3168961 tgcttgatgt tttttcgccg cctcgtgata cagatcaagc ttgttttttc cgatttccca 3169021 cgggtggggt ttgataatga tttgcagctg cttctgatca gaaagcccct gcagcacacc 3169081 ggaataaaag tcttctgaaa agggctgagt ggcaatgagc acaatttttt tagtcggctg 3169141 aaaagcaagt tttcgataga atatggacat atccataggc gttctgttaa aaatctgatc 3169201 gaagcgggga tgtcccgtta cgagaatctg ctcgggttta cagccttttc gtatgaacca 3169261 ctctgcttca tacgcaccaa aaacagcttg ataggttgta aaaacaggaa tgaaggcttc 3169321 atctcccatc aatgcgccat gctgaagaca aatgctgacg gccccttttc tttgacacat 3169381 gagagcgagc accctgctgt aaatgtcttc tgccgttccg acaataacag ctgaaatctt 3169441 ttcctgttca aacagcgcat caactgtatc aatggcctct ataaataaag gaatatcttt 3169501 gaaaagccgg tcgcgaaacg cttgatcacc aaatgccggg tgatcatcat aaggggcgag 3169561 aagcgaacag gctgtttcga gatactgctt cgaatcgcct ttttggcatg aatccgcaat 3169621 ctcccgcttg ctaattacag gcagatcaca ataatgcggc aaactccatc tggccaaaac 3169681 agccgttttt tcaggatcaa attgatagta attttcgttt gaaaaacgca ggtaatcaaa 3169741 gtgcaaaatg actttccctt taacaggttc gtcatttgtt ttaacgatgt tttggattct 3169801 ttcttcaaaa aacggctgaa tctgtccctc atcgatatgc tgatccaccg atccgaataa 3169861 ttccggttct tcttccatca tcaccctcag ttcagggctg atgtattgat aaaaattact 3169921 gataagccca agcggaatcc ctttgtagcg aagtttgtca aaaagctcca cgtacttccg 3169981 gtacagcacc caataattgc ttaaataggc cgacaagctc tcaccccatt ccaagctttt 3170041 ttaatgattc acgcagctct cggcaatttc gctgcggagg aaggttcctg acaaattcat 3170101 ttttttctaa ttcaaacagc tgaaagtgaa tcgattggtc ggtaatataa ttcaggtcca 3170161 gctcctcatc cagtgggtaa aacggataaa aatgattgac tctccaaaag aaccgggcat 3170221 ctcctatacg gtaaaacgcc gggctttcat cccaatagga gccaaacttc tcctttacct 3170281 tctcaagcac cgaatacctg tgcatcaccg agcaatgatc aattgcgcac ggcgcgttcc 3170341 atgtcacttg agcggcaggc ctgacagttt cttttacaat gtcacgattc tcgtttaaat 3170401 gataggtttt ggaggctgag taaatcacag ccttttcagg atgggtatcg agctcccgca 3170461 ccattttcag gaggcggtcc ggcatataga tgttgtcatc cgtcgcatag gtgatatatt 3170521 caccctccgc catctcaatc gcctgattga tcagtgccgc gtatctcgtt ttttctgttc 3170581 tttccttcac tccagatata tcgctttgat aaaaacgcac tcggttatca ttcaaaaaag 3170641 gacggattac attcagcgtc tcttcattgg agttgtcatc cataataaac aattcaaaat 3170701 ctgaaaacgt ttgtgagagt atgctagaaa tggactttgc cacataatcg cttttgttat 3170761 agctcgtcat aatgactgat actttaggca aatcctacac ctccttcttg gaacttcaca 3170821 cctgaaacta tcgttatctt atgttgctta tgctcaagtt gcgctaggga tacaaaccaa 3170881 tatgcgaaaa gtttgtgtat gtttctgaaa aacagcggct gcccagagcg aaatctgatc 3170941 ggtccgctgt tctttttcag cataatccaa gcatcagcct cataaggtga aagagataaa 3171001 aatcgcacca gcgactaaga tcgttttcca tcggaggtga gtcatcgcgg agcgttcacc 3171061 tatacatcca gaacatgttt tgaatggttt tcataaaaag gaggaacgat atgaaaccga 3171121 aaaaaaatca atatcagcaa atgcaggcat ttgataatat gcaggggtat cagcctcagt 3171181 ttggcgccaa cccgtacccg cagcaaggcc aaggctcaca aatgcagaca atggggatgc 3171241 agccaatgat gccaatgcag cagggacagc aaggacaaca aggacagcag ggatttggat 3171301 tcccgggcca gcagcagggc ggcggttttc aaattccatc ggggcctaca ccgtcaggac 3171361 cgggccaaag cgttcccggc atgctgcctg ttgaggaatc ttacatcgag aatattttgc 3171421 gcctgaatcg gggaaaaacg gccaccattt atatgacatt tgaaaacagc aaggaatggg 3171481 gctcgaagat ttttcgcggc gtcatcgaag ctgcgggccg ggatcacatt attatcagcg 3171541 acccgaaatc aggaacacgc tacctgctcc tgacaatcta cctcgattac attacatttg 3171601 atgaagaaat tgcttatacg tatccatatt ccatggcgtc ctattcgcca agataagaaa 3171661 aaagccaatc actcatatga tgaggattgg cttttttgtt tatagatatt tgacggctgc 3171721 gacaacgatc ataatccaag aaataataaa cgccacaccg ccgagcgggg tgatcgctcc 3171781 aagaatggag atttgcgtca cacttagaat atataagctt ccggaaaaca gcacaattcc 3171841 cgcaaacatc agccagccgg ctgtcgtgac actgcctatg ccggataatt tatcagccag 3171901 aaacgcgaca acgaataacc caagggcgtg atacatatga tactgcacgc ctgtgtgcca 3171961 aacctgaaga tacttatcag gtattttccc ttctaatccg tgagcgccga atgctccgag 3172021 tcccacggca agcagggcgt taatggcccc taatatgata aaaactttca tctatctctc 3172081 ccgccttttc gttaaactca tatcatttat cttatcgcac ctgcaccaaa attcaatgtt 3172141 tgttctccgt tgacacgaga ttgtcggatt ttctcctgcg ccaaagctgg aactggtcag 3172201 ctgctattgc agcaagcgtc cctaatacga gcccgttgct taatagagaa ataaataccg 3172261 gatgcaatcc ctttaacgca gtttcaggaa caaacatgat accgacccct gtcagcagtg 3172321 agataccgat gatagacctc accctttttg attcttcttt ctcatatgaa tcaaattcgg 3172381 caaaggccag accgcccatt gcggagaaca caacaaaatt caccgcaaat ccaacgggtg 3172441 acggcaggct cgcaaacgta ttcataaaaa acgggatcac gctgatcacg ataaccagaa 3172501 tactgccgag cataaacggt tttttagaag gcatcttggt cgtttcaata aaacctgcgg 3172561 ctcccgaaat cggaacaggc gcaatagctc ccgtcaaacc gctaagcaga tggctgaatg 3172621 aagctgcaaa accggcatgg cgttcatgat gctttccatc aggctgtttg ctgaattttt 3172681 tcatggcgat gtccacgacc ttcatgctcg ccagcatatt cacgatcagc aagatggtaa 3172741 taaaaataga agtgatgatc aggccgctgt taaataacgg ggtcccaaaa ggaaacaggg 3172801 aaggcagctg aaacagccgg tccggcattt caatcggctt tgcggctccg gcagccgcaa 3172861 acagcaccca cccgccgaac aaggctaata aaatagaata ttgcttaaaa aacatgatgt 3172921 tcgaatttgt cattataaaa gcggcagcga tcacaacaag cgccaggcca aatacaagac 3172981 cgtccacccc gtcctgtcga taaccgattc cgagaattcc ttttataatg ggctgactca 3173041 gctgcatgac aagaagcaat aaatagacgc ccgttacaac cggagtaaac aattttgcaa 3173101 gtctgtcaat gaccttgaaa acacttaaca aaaagaaaca tacagcgctt acaagaagag 3173161 ctccctgcaa accccgcagt gtgtctccat atgtcgcaaa cacagttccc gtcagccctg 3173221 cgtaaatcgt atacactccc caccacaagc cggctgggct ttcattgatc ggcagtctgt 3173281 ggcctttcaa acactgaatg acggcggcaa ttcccagtac aaaaaaagtg ctttgaatca 3173341 atcttgcaga atctgagtga tccagatgaa acgactgggc aaccgccacc ggaacaacaa 3173401 tcgccgcagc aataataaac gctgtccatt gcagcgcgcc aagaaccaat ttcacgtaag 3173461 ctcaacctct ctctttaaaa atcaaataaa gactctccgt ttccatcctc ttcctgcttc 3173521 tctttttctt gctttcgata tttgtttaat cccgcgctcc ccatcatttt ttccatcatc 3173581 agctggtctg tcgatggcgg cgcggcggga cttggcgtaa cgctcggctg tatgcggggc 3173641 gcgctcgcgt tctccggctg atcaagcacg acatcacaca gagaacggac aaccgctaca 3173701 taacgcttca gctcctcatc ccgttcagcc gtttttgctt tttttagctc ttcttccatc 3173761 ttttgaatca aagcagatat atgaatgttc atgaagcacc ctccaaaaaa ataaatgttg 3173821 tcttcctgca ttttatcaaa ttcctgctga aaacgcagat atgagtttgt tattttttct 3173881 gacaaacctt gcgcgattga caagcagaag agatttttca cataataaat caccatacct 3173941 tacaaaaagg agaaacggaa tgaacagcat cccctctatc atcagcaagc ataaagccta 3174001 ttttgcggcg ggacatacga gaccgcttga atcgagactg aacattttgc gaaagctgaa 3174061 acaagccgtc agaactcatg aagccgatct catagccgct ctctaccagg atctccataa 3174121 atccgagcaa gaagcatact caacagaaat cggaatcgtc ttggaggaaa tcagctttgt 3174181 catgaaacgg ctgagaaaat ggtccaagcc gaaacgagtc aaaacgccgt tgactcatct 3174241 aggctccaaa agcatcatca tccctgagcc gtatggaacc gttttggtga ttgcgccttg 3174301 gaactatccc ttgcagctgg cgctttctcc gttgattggc gccattgcgg cggggaacac 3174361 ggtcgttctc aagccatcag aatatacgcc ggctgtttct gctattcttt ccaaactcat 3174421 cagcagcgtt tttccaactg attatgtcgc tatggcagaa ggcgggcccg atgtcagcac 3174481 agcattatta cagcagccct ttgactacat tttctttacc ggcagtgtag ctgtaggaaa 3174541 aatcgtcatg gaggccgccg ccaaacaatt aattcccgta accttggagc tcggcggcaa 3174601 aagtccctgc atcgtccata aagatgctga cattcagctt gccgccaaac gcatcgtctt 3174661 cgggaaattt acaaatgcgg gacaaacctg catcgcaccg gattatttat ttgtccacga 3174721 ggacatcaaa acgaagctca cagaagaaat gaagcgtgcg atcagagaat tttacggccc 3174781 tcagccggaa cggaatccac agtacggcaa aatcgtcagt gagcgccact atcagcggct 3174841 gctcagcttt ctgaatgatg gcatcccgct cacaggcgga caatctgatc ccaatcatca 3174901 caaaattgcg ccgaccattc tcgaacaagt gagagatgac tctccagtga tgcaggagga 3174961 gattttcggg ccgattcttc cgctctttac ataccgcaat atcggggaag tcattgagaa 3175021 agtccaatcg cgccctaagc cgctcgccct gtatctcttc accacaaaca aagaaattga 3175081 gcgcgctgtt ttaggaaatc tgtcgtttgg cgggggctgt gtcaatgata cgttaatgca 3175141 tgttgcgacg ccgtatttgc cattcggcgg cgtcggggaa agcggcatcg gcagctatca 3175201 cgggtttgac agttttaaca cattcacgca caaaaaaagc gtcgtcaaac aaacgaaccg 3175261 tttcgacttc gcatttcgtt atccttcctc caaaaacggg ctgcgaatga ttcgaaaaat 3175321 actcaaataa aaaagcgcag atcacctgcg ctttttacaa atccttaata caccaatcaa 3175381 tcggcgcctc tcccattttc tccaaatagg cattcgcccg ggaaaacggt ctgctcccga 3175441 aaaatccgtt tctcgcagaa aacgggctgg gatgcgtcga ttcaatgata aaatgcttgg 3175501 aggtgtcgat ccgttctttt ttcatttgag catgccgtcc ccacaaaata aagataaccg 3175561 gccgctctct ttcactcagc acgtcaataa ttcggtccgt cagtcgctcc cagccttttc 3175621 ccttatggga attcgcctgt ccgcgcctta ctgtcagcac agtattcagc aaaagaacgc 3175681 cttgctttgc ccagctcaca agcgacccgt gattcgggat gctgcacccg atgtcctgct 3175741 gcagctcaag aaagatattt tttaacgaag gcggctgctt tacaccgggc ttgacagaga 3175801 agcttaaacc ttgagcctgt cccggcccgt gatacggatc ttgacccaaa atgacgacct 3175861 tgacatcatc atatgatgta taatgcagcg cgttgaaaat atcccggctg tccggataaa 3175921 tcgtttgctc cgcgtattcc ctcttcagca tctctctgag ctcttgataa tacggtttct 3175981 caaactcttc ctttagctga ttccaccagc tgtcttgtaa aagctgtttc aagattcagg 3176041 cctccttacg aacgatgaag tctggaatag acaggctcgc catcccaaac catttcactt 3176101 tttgcttccc gcctcttcat ctcaggctct tcaagcagga cggcaaagtt tttcgtcggc 3176161 agctccccga gtccgtgctt ttcacttaaa cgatccaaat attgcttccg cttggcgcca 3176221 aggtcagcag actgattgtc tcccgcgtca ctgaaggcat aaatcacgct ggcgcaaggg 3176281 acacgcttca cccggtaatc cttggccgcg cgcaaataaa aatcccagtc ccagtaattg 3176341 tgcacatcag catcgaaata cccgatttca tcatgcagaa aacgtctgta catgctgccc 3176401 gacggcacgt atgtagaaaa cactctcata tcctcatagt cagcggtata agcaaacaat 3176461 ttccgtgaca ctggatacct tgttccgttt ttctcttcaa acgaaactat ttccgcatca 3176521 gaatgaacga agtctgccgt ttctatttcc tttgccattt tctcgatatg ccctggcgta 3176581 aagaaatcat cgtcatcaca cagcataatg caatccccag acgcctcttt tacaccggca 3176641 tttctcgcag ccacatgccc cgagttcttt tctaaattga tgacagcaat cggcagctcc 3176701 ggataaagtg ctttgaccgg cacgaccgat tccccggcat cattcacaat aataatttca 3176761 tacggcatca aggtctggcg ggaaatcgac tccaaaagct cacacaaagc cggaatccga 3176821 ttataggtca caattacgat agaaatcttc atgatgctct ccttctcatt ttcatagtca 3176881 tgtactatta aaacatatat tggacgggag atcagtggga atatcctact gaaacggcat 3176941 actacaatga tagaaacagc aaagtggctc cgatcagaag caccatgatc agcatcagat 3177001 ctccaaagac atgaaagata tctttcatgc ggacgccatt cggaaggata agacgccaca 3177061 gcttagattg atagaccggc agcagcacca gtgcataaga aagacacaaa aatgtaaaag 3177121 ccggcggcac aaaagcacag cctgcatcgt cccaattcat catgatgtct ttcatactag 3177181 atccatccaa taaaaacaaa gatatcatga gggctagcaa cacaaaggac cccaattgaa 3177241 cctcaaacag gcgcattttc tggttatatg caaatcggac cgcccaaaac cagacataag 3177301 catatgaaca tagcagcgta agaatggcac ctgctgtaaa gacgacatca ggcagccgat 3177361 caagcagaaa aacaaaaggc aagctggctg ccatagccaa gagcatgcag ccaccagtaa 3177421 acaaaaatac tgccccatga gctacaaaac catataaaca agagctaatc ctcacgacat 3177481 acacctcctt tacatagaaa ttctatgtat atacctaaaa aatcagacaa gctgacgcct 3177541 gccaatataa cagcccattc ggccaaataa cggaaataac agcgttgcaa aagcacaagt 3177601 tccaacaaac caaggtgtca acaaggattg aaacagcgca gcaggaatta cattgaatag 3177661 aaaaacaagc ataaaaatga cgtttggcac cattgagatc agaatcgtat gtagaacaag 3177721 cttttctccg cgttttccaa actccttcac gccttgatac ccaatcagca cccagtagat 3177781 catatatgca gctaagatca gccaaacaga aacagaaatg cctttccata ctgcttgaac 3177841 aaacggtgat tcaagccata catgcattat tgtaatcgca atgccgacag cgaatagggc 3177901 actgttacag aaaagatgga acatcaaaaa cgcacgaaac gttactggct gtattttctt 3177961 aaacgaagaa acaatgtcag ttggtgttcc aaacgcctgc aataaagtct gcatagcttc 3178021 ctcctcactc tttccttcct gaaaagagcg aaacagatga tgttcaatat ggctctcaat 3178081 ctcttctatc atcgcctcac cctcaggaag ccctttaagc ccgcttttga tttcggatac 3178141 atatgtttct ttatccattt tgtccgctcc acttcagtat tcggtccatc atggctgaaa 3178201 atacgctcca ttccttcgtg cgttccgcca gcacttcttt gccctcgtct gtaatccggt 3178261 aatatttgcg gtccggtcct ttctcctgct tctcccagta ggaagaaata tacccttggc 3178321 gttcaagctt gtgaagagaa ggatacaagg tcccttcttt catctgcagt tcatttccgc 3178381 tgcggcttcc catttctttt acaagctcat agccgtacat cggccgctcg ttcagaagcg 3178441 tcaataccaa tataaccgtg cttcccttaa ccagctcacg atttaacatc tcaaaacccc 3178501 tacctagttt tcttatgtag cattttacga aagcccgttg agattgtcaa atgattccta 3178561 tagatcttct atattgtgat acagagaaaa tctaactata atgaaagaca aaacatgatg 3178621 gaggttcaag acatgtctat gcataaagca ctcaccattg ccggctcaga ttccagcggc 3178681 ggtgctggga ttcaagctga tttaaaaaca tttcaagaaa aaaacgtata cgggatgacc 3178741 gccttaacgg tgatcgttgc gatggaccca aacaacagct ggaaccatca ggtattcccg 3178801 atcgatactg atacaatccg cgcccagctt gcaacaatta cggacggcat cggcgtggac 3178861 gccatgaaaa caggaatgct gccaaccgtt gacattatcg agcttgcggc aaaaacgatc 3178921 aaagaaaaac aattaaaaaa tgtggtaatt gacccggtta tggtttgcaa aggtgctaat 3178981 gaagtccttt atccggagca cgcccaagcc ctgcgtgagc aattggctcc gctagccact 3179041 gtcattacgc caaacttgtt tgaagccagc cagctcagcg gcatggatga actaaaaaca 3179101 gttgacgata tgatcgaagc cgcgaaaaaa attcacgcac tcggcgctca atatgtcgtc 3179161 attacaggcg gaggcaaact caaacacgag aaagccgttg atgttctcta tgacggagaa 3179221 acagcggaag tccttgaaag cgaaatgatc gatacgcctt atacacatgg cgcaggctgt 3179281 acattctcag cagccgtgac agcggagctt gccaaaggtg cggaagtcaa agaagccatt 3179341 tacgcagcga aagaattcat cacagcggcc attaaagaat ccttcccgct aaaccagtat 3179401 gttggtccta cgaagcattc tgcactgcgc ctgaatcaac aatcataaaa aaaggggctg 3179461 ccttacagag aggcagccct ttttaaatca ccgaagactt ttcacagaaa aaactgccga 3179521 tcccatcggc agcctgttta tttgattttt aaattgtttg cagatttcct caaaaatgtt 3179581 tctatcgact gaacaaaaag tgcatattcc ttcatttgtt catatgcccg cgtgagaatt 3179641 tccgccgttt cactgtgcgg cgttgttccg ccaagcattt ttttcagctg aagcagcaca 3179701 tccttatatt cttctcgctt atcttcaact tggttagcag ccttttccaa acattccggt 3179761 gttatcttct gttcatgtat attcaagaaa acaactcctt ttacagaaaa aaatagtagg 3179821 ttatcgttga agaatagcac agatggctca gatttcacat aagaaaatag aaggattttc 3179881 tacataagtg tccaaattcc gacattcatt tcagatttcc cggtcgcact ggctgttact 3179941 tcatgatttc ccgggaaagg aaaatatctt gcactcaaga cctcttctcc gttattgata 3180001 aagatttcca cagatgacgc gtcgagaaac atgtgtacgg tatgcaaatc cttgatgcgg 3180061 caatgtctcg cttctgttct ttttccgtca aagctctttc gttccagcgt aacaatcccc 3180121 tcgtctttat ggaaggaaaa cgtagccgtt ccgcggatac tgattgaaaa gccagactcc 3180181 gtatgaatgt cttccagtag aatctcagtt ctttcaggtt tttccactgg aagcgcacca 3180241 gatgatccat gcatgttgat gtgtattttt ttctcatttc tgcgcatggc ttttagctca 3180301 ggcagcggct gctgaatcag cttctgtcct gaaagcgtca gctgtctcgg cagcgtcatg 3180361 cagtgaatcc agtggcagtc aatggtcgga tgggaccctt catcctgatc aggcaccgcc 3180421 atccatgcaa ataaaatccg ccttccctga tcgtcttcaa gtgtttgcgg cgcgtaaaaa 3180481 tcaaaacctt gatcaagctc cgtaaattca ccatgcttca gttcaggctt gttataatcg 3180541 aggcggccga caaaataacc tgattgatat acgttctgat aacggaaacc gtcagcctca 3180601 agcccttgag gcgaaacaat cagcacatcc gatccttgaa gggaaaacaa atcagggcat 3180661 tcccacatgt atccaaaatc gtccagcccg ttgaagcccg cgccggttat cgggccaaga 3180721 aatctccact ctgtcaggtt atcagaagca aacaacacag cctgcccttt caaattctct 3180781 gtttgcgcac caatcaccat ataccatgtg ccttcatgct cccatacctt cggatcgcga 3180841 aaatgcgccg tatatccttc cggaaggcgg gcgacgacac cctttttctc aaaggacagc 3180901 ccgtcgtcag aaacagcaag gcattgatac gtttcccgat ttccatcctg atccctgaca 3180961 tttcctgtgt aaaaaagata gagccgatcg tctttcgtga cagcgctgcc cgagtagcag 3181021 ccgtttttat caaaccaatc actcggagcc agcgcaatct cttcccgctt ccaattcaca 3181081 acatcctgtg tcgtataatg cccccaaaat tttgcgccgt gccccgtctg aaacggctgc 3181141 cactgaaaga atacatgata gctgcccttc caataaatca cgccattcgg gtcattcagc 3181201 agcccaaccg gcggcatgat atgaaaatgc tggcggtgcg gatcgctgtt agcgatgggc 3181261 tcttttttct ccacttcttc ataagcccgg cgacgaagct cctggtcatg tgctgtcatt 3181321 ttttcctctc ctcatcctca ttaatcttca tgacaaatgc tgcaatgaac gctgacactg 3181381 ccgcaatcgc catgccaatc agatagtgaa tcaagttgct gaagccaaac ggagccgcaa 3181441 tggcgatcat cggaattccc gttaacccgt aagcgtttgc agctacatgt gtaaagacga 3181501 catatgcccc acccaatgcg cctccgatca tcgcggcgat aaacggtttt cggtagcgca 3181561 gattgactcc gaatatgacg ggctcagtaa tgccgagaaa agcggaaaat gctgccggaa 3181621 gcgcgatttc ttttgtcttt gcctttttcg ccataaagaa gacggcaaga cctgccccgc 3181681 cctgtgcgac attcgccatt gaccagatcg gcagcaagta gtttttgcct atatctgcaa 3181741 ttagccctgc ctcaatcgca tggaagctgt gatgaacgcc tgtcagcacg atgagtgaat 3181801 acgtgccccc gaaaatcaga cctgcgacaa aaccggcatg gtcatataca taagttaaag 3181861 caaccgtaat gccggagcca agcgctctgc ctagagggcc aatcgcgata aaagcaacaa 3181921 acccggtgac aatcacagta acaaatggtg taacaagcaa atccaccgca tgtggaacca 3181981 cttttctcgt ccatttctct accttgctca tcacatacac cgcaagcagg acagggataa 3182041 cagttccctg gtagccgaga agagcgatat caaatccgaa aagatgcatg taatcaggtg 3182101 tcgcttccgc caatccccat ggatttaaaa gattcggatg aatcatgatt cccccgatga 3182161 ccgctcccaa gtatggattg ctgccaaact cttttgaagc gctgaccccg attagaatcg 3182221 gcaagaaaat gaatgctgca cttgaaaaca tatcaagcag ctgcaaaagc gcagaatcct 3182281 tgctcatcca atgaaacgca ttgatcatac ccagcaatcc cattaatagg ccgctggcta 3182341 caatagctgg gatgattgga acaaaaatat tagaaagcgt tttcgcaaat ctcgcagcgg 3182401 gattcagctt ttcttttgcc gcatcctgat gattgacgtg ttcttcacgc tcgatatcag 3182461 cttctttaga aaaggcatcg aatactttat tcacaaggcc tgttccgaaa atgatctggt 3182521 actggccaga gctgctgaaa gcccctttaa cgccatcaag ctcttctact tgtgcttgat 3182581 ctatctttga ttcatctttc atcactaaac gcagtcttgt tgcacaatga gccgcgctga 3182641 taatattttc tttccctccg agaagctcaa tgaggcgttt tgcagtctct ttgtaatcca 3182701 tctatttctc ccccttttat ttaaacaaaa aagacctaaa attcgccaac gaataaagga 3182761 cacagcgatc ctttttcatt tacgcaaatt ttaggtcttg cctgctttac cagtcacaat 3182821 cccgcttatt cagattaaga atacgctttc atcataaatc atgatagcgt tttcgtcaac 3182881 tattttttta gttaaatagt ttgatataac atgtagacaa aaattcgtaa aaattaattg 3182941 tgaaatactt cacaatatcg tgctatacta tgctcaatca tgaaagaaag caggaaaaga 3183001 caatggaaac tcaagcatta caaaaggttg aacagtatgc tttgaaaaaa caaaacatat 3183061 tcgcttcaag caaaatccgt tatgtgcttc ggtccatttt ggccagtata tttattggtt 3183121 ttggcattac agccgcaagc aaaacaggca gctatttctt tatggctgat tctccgtttg 3183181 cctttccggc agccgctgtc actttcgggg ccgctattct gatgattgct tacggaggcg 3183241 gagatttatt taccggcaac accttttatt tcacctatac cgcgctccgg aaaaaaatca 3183301 gctggcgcga caccctatac ttgtggatgt caagctatgc cggcaattta atcggcgcca 3183361 ttctgtttgc catcctgatc agcgcgacgg gactttttga ggagccttct gttcattcct 3183421 ttttgattca tttggcagag cacaaaatgg agccgccggc ttccgaattg tttttcagag 3183481 gaatgctgtg caattggctt gtgtgcctcg cctttttcat tccaatgtct ctcaaagggg 3183541 aaggagcaaa gctttttacc atgatgcttt tcgttttctg cttctttatt tccggctttg 3183601 aacacagcat tgccaatatg tgcacattcg ccatctcgct tttgatcgag caccctgata 3183661 cagtgacact gatgggagca gtcagaaact taatccccgt tacgctcggc aatctgaccg 3183721 cgggaatagt tatgatgggc tggatgtact acacactgaa tcctgatcaa taaaaaaact 3183781 tccagagatc actccctgca agtcaaagcg gttattccga gagatcttga agacgctgga 3183841 catgcagcgt gatatagccg gcctcggatt ccggcaaatg taattgatat tcatttttca 3183901 aaaactccgc cagctccagc gcacattgat aggcgaatga atactttttt tggatgaaat 3183961 aaagcatctc ctcgtccata cgatggagcg cttcatttga ttccaaccgg ctgaccgcgt 3184021 atcgcaaatg cgtgacaagg cgttgatagg aaatgctgtt ttcatccacc tttcgattaa 3184081 agtattgttt tattttctct atcatttctt tgatcatggt cgtatgcttc agcgctgaat 3184141 acatgctctc cgcatccatc ttcgccgtat ggatgtgaag ggcaatataa cccgcttcat 3184201 cttcaggcag agacacgccc aatgtctctt ttacatgtcc gatcgcccac aggccgatct 3184261 catattcttt tttatagagc gcctttatct catgcagcaa tttattctgc acaagcagcc 3184321 cattttgaat cctttcgatc gcaaaggaca aatggtcgga aagcgcgata tgaatgtgat 3184381 cgctcagcgg cgccgcgagc tctccttccg catagctgat gatatcctca gctatttcta 3184441 tatgctcctc cggcagtgtt tgcaggattt gtttgaactt ttcattctcg tcgcgcacga 3184501 caaagatctt ttccacttta ttcataggga tgagatcatt tttctttttt tgaaaagcga 3184561 ttcccggtcc catcacgatt ttttcctgat catcctcttt tattaaagcc gcattgttgt 3184621 ttaatacttt atagattttc aagaggttat ctctcccgcc aatttgcttt tgactgggat 3184681 tttacctcct tttgaccgcc atgtaaagat gcgggcccgc tctctcctgc tttggcgatt 3184741 ccttgaaggc ttgcaaacat cttcttttat aaagcgcggc ggctttcgct ttctgctttt 3184801 cttcctcatt cacagccatc cgccattcat aaaacgaaac gagtcctgcg gcctgcacag 3184861 ccgcctttct ttggtatgta cgctgagccg aatagaccgc ggcagccgca gtttttctgt 3184921 ccggcgtcac ccagttcatc aaaaagacca tccacacccg taaagataca agcaaacgtt 3184981 tcatagaaaa acatccctcc gcttcttttt ggcaggcagc ctttttagca gcccgttttc 3185041 tcagccgcag cccgcaagaa aagacggccg atttcttttc tcgcaaacta gcggctctag 3185101 caaaactcat gactctatga tagaccgtgg aaagagaatt ctttgtcaca atatgagtga 3185161 aaaaaccaac tagtttttag aagttttgtt gaaagctgaa agaattgaaa tgaaaattgg 3185221 agaaccgctt tgaaaacttt atacacaagt tatcccaaag ataagaacaa cttaatcaca 3185281 agagatatcc acatgtccac aaactctatc tatattttgt atacgaacgt atattcctaa 3185341 ctatatatat acacaggttt attcacttat acacagggtt ctgtgtataa ctccttcgtt 3185401 atacacaaac aaaatccaat aaatggtcca aatgacacaa ggattttttt gaattttcaa 3185461 gaaatatata ctagatcttt cacatttttt ctaaatacaa agggggaaac acattgaaaa 3185521 aggggatcag tcagcaaacg cctcctgcaa taagcgatac gatcggagct tatcttcaaa 3185581 atgatgcgtg atggtcacca ccatgatttc ctctgtttca tacgcgttac tcaaagctaa 3185641 cagccgctcc ttaacctgtt ctttcgtacc aacaatcatt cgatttcgat tatcagcaat 3185701 tcgtctctgt tcataaggag aatacgtatt tttccgaaca gcttcatacg aaggaactcc 3185761 ctctaaagga ataccctgct ctcccgccaa aagtgtaaaa tcaagcacag ccccaagctc 3185821 ctctgccttc tcctccgtgt cagcacaaag aacaaaaaca gcaactgccg ctcgaggcgt 3185881 atctcctaac acagacggtt tgaatcgcct cttatactgt ctgacagtac cctctccgcc 3185941 ctctccattg ataaaatggg caaacatata gccagcgcca gattcagctg cgagcagcgc 3186001 gctttctcca gatgagccga gcagccacac atccggagcc gttgaaatat gcggcgcagc 3186061 ggtcagattc ggaaaacggt gtttgtcatc cgccaaatca tgcaaataca tggtcagctc 3186121 cttaatttgc tgcggatact gatcagcatt gcgcttacca ccgtcattca gcgcccatga 3186181 tgcaatcggc attccccccg gtgctctgcc aagccccagg tcaattcttc ctggtgtcag 3186241 cccctccaga acacgaaagt tttcagctac tttataagca ctgtaatgcg gcagcatgac 3186301 tcctcctgat ccaacacgaa ttcgctttgt tttcgctgct atatgactga ttagcacctc 3186361 aggactggac cctgccagcc gttttgaaaa gtgatgctca gaaacccaaa atctcttata 3186421 tccaaggtcc tcagcagctt gggcaagcgc aacggtttgc tgtaaggccg tttctgcatt 3186481 gctgccctct gatactggag attgatctaa tatacttaat gaaaccatcc ctaccacctc 3186541 atcctcatcg tatcactgat cccctatttt ttctccaaag ccgctcacac tgcttatcag 3186601 tgtcccctat cattcgccat ttatttgtga aagcatgtcc ctatttgtcg gaatatgtta 3186661 cacgtgaaac ataaaaaccc ctccagacgg agaggtttgc tttagttttt attaaagccc 3186721 ttttctttca cgtagtcatt taaatacgta cgcggctttt gcttcataaa gttcagtatt 3186781 tgatcggacc acgtttcttc ccgcttcccg tttgttcttt ctctatagta atcagaaatg 3186841 gttttgtcat acgtattcat agtatgacgg aaatcgtctg tgttcacatt atacgtattt 3186901 tcatgataaa cggcctgctt tggcaatctc ggttttttgc cggaaaggtt cgcaggatgg 3186961 cctactgcca gtccgaaaag cgggagcaca tggtcaggcg tttgcagcac ctctgtcacc 3187021 ttgtccaatt cattccgaat gccgccgata tagcaaatgc caagccccat ggattcagcg 3187081 gcaatgctca tattttgcgc tgccagcgcc gcatcaatca agctaaccat aaacatttct 3187141 gtattctcga gcagctcaga aatatgttca cctttttcct cagccagttg ttgatggcgg 3187201 tacaaatccg cacaaaatac aaaaaagtgt ccgttcttct caacgtaagg ctgattccca 3187261 gcaagcacgg acagctcacg ttttttctca ggatcagaaa ccccgataat cgaatatgcc 3187321 tgcacatagc tggatgtaga cgcagcctgc gcacttttca ctaatgtatc aatttcttca 3187381 gctgtcaaaa gctgatcagt aaaagaccgg attgaccgat gattcaaaat ggtttcgatt 3187441 gtgttattca tcacaaaaac ctccttatca ctttttatca tatccgaaaa aaagtgatct 3187501 caaaagtgaa atgctctgca caaaaaaaga cagcctctgt aaaggctgtc tgcatatcaa 3187561 gaattaaaaa gataacttct gtatttcgtc agctgcacac ttgcattata tacaatccca 3187621 aatccgatta acgtggaaag tgtcgagctt cccccatagc tgacaaacag cagcggaatc 3187681 ccggtaacag gcataatgcc aatgttcatt ccgatattct ggaatgtgtg gatcacaatt 3187741 aacgccgtat agccaacgca aaagaaagaa gcgaaacggt taaacggatg tattttgtct 3187801 atcagaacaa caagcctgta gattaaaaag aagaacatga tgacaacaat tgcacagcct 3187861 ataaagccaa atgactcacc tattatagaa aagataaagt cagtcgtact ctctggaaca 3187921 taaaccttca aattagaaat accattacct aaaataccac cagatcctat tgccatgatg 3187981 gcctggtcaa cttgccagct gtcatttgaa tcttcctgtg tctcatttga agcagacacc 3188041 caagaagtga cccgcttaat ttgataatcc tgtattccaa ctgatttagc aacgtcagga 3188101 aagtttatca ttactaataa aattaatgaa atgagtaaga tacctgaacc agctatgatc 3188161 gcaatcaatt tccaatttat ccctgacata aaaaccatta caagaacgat aaacatacat 3188221 attcccgcag tcccagcatc ctgcatcagg ataagaccta caggaataac tgcgacaccc 3188281 gcaatcttta ataacaagtg gatatcatcc ctaagcgtcc gaactccttt aggatttgct 3188341 tttccaataa ctgaagcaag catcataatc aaaccaacct tcataaactc tgacggctgt 3188401 attgttattc taccgatcct aaaccaactt tttgcccctt taataacagg tgcaatagac 3188461 tcgggactga ttttaagaat aatcaaagat aaaataccaa tgataaaaat atataaactt 3188521 aacttttcaa gctgttctaa atcaaagtac aaaagaactg taatggctac agcccccaaa 3188581 agataaaaca caatttgctg aatccaatcc gtgttcccat actgcccaaa ctgaccggca 3188641 gcatatattg atactacgct tataataaaa aacacaccaa atataaaaat caaatccccc 3188701 tggtaaaagg ggctttgctg tttcttatat cgactcattc tatcccgcct tacattttca 3188761 tcggaaaatc actaatgttt attatacatg aaccacgttc aagatgacac gtgaagctcg 3188821 cttcctttta tgttttttca gcatttgcgg cgctttttca gctacacgaa atatgacgta 3188881 tcataaaccg aaatgtttcg attgacacaa aacttttcaa atgaaaaaaa cgccatacca 3188941 atagaatttg ttaaaaaacg aatgcgataa tgtgttatgt tcccaaataa tgtgatacct 3189001 catatagaaa tagctaaaaa ttcagagccc catgcccata cattctccta gcacattaaa 3189061 cgaaaaaata agacgataga tccagtccat ttctgcaaaa acacgtatca atttctggaa 3189121 aacatggtat aataattgta acagaatgtt caaaaaacaa tcacaaaaca gacacaactc 3189181 agttcctcta tttcattttt gtaaacgtta tcacaaaatg aaaggagacg ggtatgatgg 3189241 acatgttttt tgcttactta ttggttgcca gcgcaacgcc tctctttatt tggcttgata 3189301 acaaaaaagt cgcactctca gctattccgc caatcatttt aatgtgggta ttcttcttct 3189361 tttacgcaac agaaagcctt tctccacttg gacacactct catgattatc ttgtttgccg 3189421 ttaacgtcat tgtcgctcat atcgccgcat ttatcattta cggccttccg tatcttcgca 3189481 gaaagcgaag cagctgaaga cagcaaaaaa ccctcttcca ctgaagaggg ttttttgtat 3189541 tattcgttat ggcctgaatg ctctgagtgt tcagcgcctc caggaggatt tccgtccata 3189601 tggtcaccat ggtgatagtg agccgcgaaa atccagatgg atccaagtac gataacgatc 3189661 gcgccaaaga atccgaacag cgtgtttccg acttggatcg tgccgttttc gctctctgtc 3189721 atatgcatga acatgagaag ctgcagcgcc gcctgaatga aggcgaagcc gaagataatc 3189781 caaagttttg ctgatgagct caggtcagta tacactgcaa cccatagagc cagcagggtc 3189841 aaaacgatag acaggataaa acctacaatg tgtttccatg gaaagtgact gtgttcagca 3189901 gatttgtttg ccattttaca gaccccccaa tcccatgaga tagacacctg taaagatgaa 3189961 aatccataca acatctaaga agtgccagta caagcttgag ataaagattt tagatgaagt 3190021 ttgcggagtt aagccgcgtt tcttcaactg aatcagaatt cctgtgatcc agaaaatccc 3190081 gattgttacg tgagttccgt gagttccaag taaaacaaag aatccagacc agaacgcact 3190141 tgtactgaga gccgctcctt catgtacata gtgaacaaac tcgttgatct cgcatccgac 3190201 gaagccggca ccgagaagaa gagtgataat tgtccaaatg actacgcctt ttaaacttcc 3190261 gcggcgcatt tcatgaacag cgatcccgca ggtaaagctg ctgatcagca gcaagaacgt 3190321 cataatcatt accagattga cttcaaatag ttcgtctggc aagacacctc cagctgttct 3190381 gtttttaaga acgaagaagg ttgcaaatag tgttgagaac aacacaattt ctgcccctaa 3190441 aaagatccaa aacccgagaa tattaagtct gccggtttca gattgatatt ccataggcgc 3190501 gttagaattg ccgtgttctg catgttccat aactcacgcc tccttattcg gaaatctttc 3190561 tttccgtctc ttttatttca tcaacactaa tgtagtagcc gttgtcgtat tcgaatgaac 3190621 gcagaaccat gcagagcagg actccgatca atccgactac gcccatccag taccattcaa 3190681 agacaagtcc aaagcctgcg agaccgaagg caacagacat aaagaacggt ctgcctgagt 3190741 tgcttggcat atggattttc ttgaatttgc tttcagggta taattcagtt ttttcttctt 3190801 tcatatgcag gaatgcatct tgagatttga cttcaggaag caccgcaaag ttgtaatgcg 3190861 gcggaatcgc agaagaagtc gcccaatcaa gcgtacgtcc cacaccccat gaatctccgc 3190921 tgatttcacg agtagagtaa cggaagctgt agtagatgtt atagcaaagg attaagaatc 3190981 ctacacccat catgaaagct ccgactgttg agataaagtt caatgttgtc cagccgtcat 3191041 tcggtccgta tgtgtaaata cggcgcggca tgccttgaag ccccaagaaa tattgcggga 3191101 agaaacaaat attgaacccg atcataaaga tccagaagaa ccattttccg attctttcgt 3191161 tcagcttgtg gccgaacatt tttggatacc agaaaataaa tccggcgaaa caagcaaata 3191221 cagtacccgc aatcagcaca tagtggaagt gagatacaag gaagtacgta ttatggtatt 3191281 gataatccgc tgctgccatc gcaagcataa cccctgtaac cccgccgata acgaagttag 3191341 gaatgaacgc aagcgcccac agcataggtg ttgtaaagct gattcggcct ttatacattg 3191401 taaagagcca gttaaagatt ttaaccccgg ttgggattga gattgccatt gtcgtaattg 3191461 agaagaatga gttaacggac gcactgttcc ccattgtgaa gaagtggtga gtccaaacta 3191521 agaaactcaa tacagagatg gcgataatag aaccaaccat cgctttgtaa ccaaacaatt 3191581 gttttcttgc aaagcttgag atgatttctg agaaaatacc aaacgccgga agaataacga 3191641 tatatacttc aggatgtccc caaatccaga acaagttagc ccaaagcatc ggcataccgc 3191701 ctgcttccaa tgtgaaaaag tgagcgccga acaaacgatc aaatgataaa agtgctaatg 3191761 ctactgtaag tacagggaac gcaaacacga taataaccat tgtgatcagt gttgtccatg 3191821 tgaacatcgg catacgcatt aatgtcatgc cttttgttct catttttaag attgttacca 3191881 taaagttgat ccctgtcatc agggtaccga taccggcaat ctgaagtccg aggaggtagt 3191941 agttctcacc cggcccaggg ctcatgtcgt tacttgcaag cggcatataa ctcgtccagc 3192001 ctgcgttcgg agaacctccg ataacgaaag aaatattgaa aagcatcgcc cctacaaaga 3192061 acgtccagaa gctcaggttg ttcaagtaag ggaacgcaac gtcgcgggca ccgatttgaa 3192121 gaggcacaac aacgttgata agaccgatta agaacggcat cgccatgaag atgatcatga 3192181 ttgtaccgtg agttgtaaaa atttcattat agtggtttga gtctaaaaaa ctgttattcg 3192241 gaagcgctag ctgggcacgc atcatcagac cgtcgacacc gccacggaat aacataatta 3192301 cagcagatat aatatacatg attccgagtt ttttatggtc aacagtagtt atccattcag 3192361 accacagcca tttccacttt ttgaagtaag tcagaacaaa aataatggca atggttgaaa 3192421 gcgcaatgga aacttgtgcg cccagaatta atgggtcacc agttacgaaa aattcgtccc 3192481 atttgaattt catgcaggct tcctcctttc ctgatcaata tcattcttct gtatcatcag 3192541 acttcttaaa ttcgtttttc tttacgtttt caaacggatc tgttttagaa tgcggtgaaa 3192601 cggcttgata gccaaggcgt ttgcgcgcct ccatcgcgta ctcagcgtct tgtccgtgat 3192661 caacgtattt caagtgagta gaagagaacg ttaattcgtc cacattttca ggaagcatca 3192721 attcatcata cttctctttt gtcagcttag gagcctcgtt ctgagtcttt ttcacccagc 3192781 tgttaaagtc tttttctgtg actgcattca catcaaactc ttggtctgca aaatgttcac 3192841 ctgtgaagtt cgcgttgcgg ccttcgtaag tacccacttt gtcagcctgt aagtattgat 3192901 ccatcagcat tcctgccatc gcatattttt gccctccaag ctgaggaatc catagcgaag 3192961 ccattgaatc tgcagatgag attttgaaca agatcgggcg gtcgacagga atgtttaagt 3193021 agttgaccgt ttcaatatcc tgttcagggt agctaaatac ccatttccag tctaccgaag 3193081 tagcataaac aacaagaggc tctttgtctt ttgttgcttc aggagctttt tctaacgaat 3193141 atatcgtctg tactgttggc acagaaagtg caatgacgat taaaattggg atcactgtcc 3193201 agactacttc taaaaacgtg ttaccgtgaa tttctgggtt ataagatcca ttatctttgc 3193261 ctttacggtc gcggtatttt actaaaataa tggtaaatag aacaaagacg accccgacga 3193321 taaacagcat aaatccgata gataacagga ttaaatcact ttgctgttca gctacaggtc 3193381 ctttcggatc tagtactgaa gcattgctgc atcccccaag gacgaaaacc acagttaaca 3193441 gcgctaatac aagcaacggt tttaatgctc tgaacaagaa gatcaccatc cttcctattg 3193501 atgtaataaa tctgaagtgc atacttcctc aaaatctttt ctctactttg ttatgctatc 3193561 aaaaacttca cttattagct ttattttttt ataaacttca tcccattttc gcttaaatgt 3193621 cataaaatcg acaaaaattg ctccaacttt attcacatct atcgcttaag atgaaaagtt 3193681 tctagttatt tccgcatata aagtaaagaa agatgatgaa gaactaattc tgacaaatta 3193741 aggtttacca caataaaaaa cttaggtcaa tcaaaaattt cattttgtta aactttctag 3193801 ataggaatta ttttttcctc gtctagcatc ttttcacacg gttaccattt taacgcatca 3193861 aatattgaaa gaaaaggcgc aatgaagagc caatatgctc tgaattgtcc gtattttttt 3193921 atgagagcat ccagttgttt atcttataca aaaaagagga atgatataag caaataaata 3193981 aaaaatagga tgtgttgcat gatgagtttt cttatttcac ttatcgtcgc tattattatc 3194041 ggatggcttg gaagcctgtt tgtaaaagga gatatgcccg gaggaattat cgggtctatg 3194101 atcgcaggtc ttataggcgc ctggatcgga cacgggctgc ttggaacatg ggggccgcac 3194161 ctagccggat ttgccattat tccagcggta atcggcgcag ccattgttgt ctttctagta 3194221 agcctgttaa ccagaaaaag aggataaaag cagcagcacc cgaagcgtca gcgctttggg 3194281 tgtttgtttt gccataaaaa tcgaaaaagc ctcaacccta gcggttgagg cttttgactg 3194341 gtttggcgcc caactgatcg atgaaccttc tgaaggcctg ttttccctct gctgtctgct 3194401 taaatacacc ggcgtgttca aggatgcgcg cgaatacatg tcccagctct tcttttatga 3194461 ctagatctac gttctctttt gttatggttc ttttttccat cgtccgaaga gcccactcac 3194521 tatgctttgc agtgagcgga ttttgttcta aggctgtttt cggatcagca gaacatagcg 3194581 ccgctgccgt ttctttcatt tcctcctgta agcggccagg caatatcgcc aatcccatga 3194641 cctcaatcag gccgatattt tcttttttaa tatggtggac ttcttgatga ggatgaaata 3194701 ttcctaatgg atgctcctca tccgtccggt tgttcctcag tacgatatcg agttcgtaca 3194761 agtctcccct gcgccgcgca atcggtgtga ccgtattatg gggcgtatcg cctgtatagg 3194821 cggcaatgcc ggctttttca tcggaatacg tctgccacgt gcggaagata tggtcagcag 3194881 cttcggcgac atgacccggt tcgtctcctt ggagcctgag cacagacatc ggccacttca 3194941 ctaagcccag cgacacgccg ggataatcat ttaattcata aacgtcttcc gcttctgcac 3195001 gtgccattgg aaaatcatgc gcgccgcctt ggaaatgatc atggcttagg atgctgccgc 3195061 cgacaatcgg cagatccgcg tttgaaccga taaaataatg cggatattgg ccaagaaatg 3195121 acagcagcct ttcaaatgtt tttttgctga tctccatcgg ttcatgttca ccttttaaga 3195181 caatgcagtg ctccggataa tagacatatg gcgagaattg caggaaccat tgttcgtcct 3195241 caaggatgac cggaatgatt ctgtgatttt gccgggctgg atgattcacg cttccctcga 3195301 agccgacatt ttctttacac agcaaacaca tcggataatt tgtctgttcc tgctcttttg 3195361 cagccgcaat cgctttcggg tccttttcag gctttgatag gttaatggtc atttccagct 3195421 cgccatattc ggtcggcacc gtccaatgaa catttttggc gattctgtca gtccgtatat 3195481 aatagacatc ctctgaatat tgatagaatt cctttgtcgc ctgttttggg ccgtataatg 3195541 cttttgtctc ttcaaatttg cgaatgacct cggacggggc aggcacaaaa cagcccatca 3195601 gctttgcgct gagcaggtca cggtacgtat ctgtatccgc ttccattcgg ccggtttcgg 3195661 cagcccattt atagatggga gctagcaagt ccggcaggct ttgtgactgc ttgatgctgg 3195721 tgctggagtt cggctcggga tgtgtgatgc ccagcgcttc ataaagacgg tttctcgtat 3195781 attcccgatc ccagatcgaa atcaattttc gttccaggcc atactcaagc agctgttcca 3195841 gatgttcaat aatactcata tgtcactccc cctttagttc tctcgctccc tctccgatat 3195901 ccgcgacata aaagtccgct cggagccctg ttttttcttg atatctgtct ccaaccttct 3195961 gaataaaatc atcaacgaac tcatctttta caatgctgat ggtgcagccg ccaaagcctg 3196021 ctcccgtcat tcttgatcca attacacctt cgtgatccca tgccgcaaac acaagctcat 3196081 caagttcagg gcatgttact tcatagtcat ccttcaatga aaggtgggat tccttcatta 3196141 actgcccgat ttcatctata ttgttctctt tgaacatatg ggccgtctta atagcacgat 3196201 gattttcgta tacagcgtgc tttgcccggc gtctgttcgt ttcattttgg atcaggctgg 3196261 aatgcgcatc gaaatcagaa ggcttgatgt cgcccagtgc ggcaatatcg aggccttttt 3196321 tcagatcaag caatgcatca ttgcattctt ggcgtctcgt attatagctg gagtcagcca 3196381 atgtcctttt tttgttcgtg ttcgcgatga ccagcgcgag gcctgagaca ttgagtttgc 3196441 tatattcata gtcaagcgtg tcacagttca gcagcatcgc atgatgtttt ttccccattc 3196501 caattgcaaa ttggtccata attccgcaat tgacgccgat aaaatggttt tccgcatgct 3196561 gcgccatttt cacaagctca agcgcatcta cttcaggatg aaaataactt tggagcacga 3196621 cccccatcag cagttcaata gaagcggaag acgacagtcc cgccccgttt ggaatattcc 3196681 ctgaaaatac aatgtcaaag ccatggggaa ctgcatatcc cctctgttga aattcataaa 3196741 tcacgccttt tgggtagttc gcccagtcgt cttctttttg atagcgaatg tcgtcaaggc 3196801 tgcattcctt gatgcctgcg tttctaaagt tatctgaata catccggaca agcccgtcgt 3196861 ttctttctgc aacagcagca tatgtaccca ttgtcagcgc gcacggaaag acatgcccgc 3196921 cgttatagtc tgtatgttct ccaatcagat tcactcttcc aggtgcgaaa aaaaaccgta 3196981 acccctcttt ttctccgaat acacttgcaa atatcccctt tagctcttcc cgcatgtgca 3197041 atcacctttc tggtttttat tttttattcc ccttatttct tcatagaaaa cggcagatca 3197101 tatgctgcag tcctctcata ccccttcttc ttttgttttt ttaaagacga gccatttgct 3197161 cgcaacatag ttgacgacaa caatgaccgc gttgtcgagt attttggcca aggtttcatt 3197221 tgtattgaac tggccgacaa gaatgatcat catgcctaaa tctatgccga gagacaggac 3197281 ccgaacgctg aaaaaagcag tgagctcttt cagcaggctc tgcagatcat gtgttttttg 3197341 ctgaaacaca tataatttat ttgttatgta agcaaacagc acggacaaaa tccaagcggc 3197401 aacagtggcg gctttgtaat ccacattcat gatctctacc aatatataaa agctggcgat 3197461 attcacaatg gttgtgaaaa cccccataat gatatacata attatttctc tatacttcac 3197521 tgatgttcct cgctttctga aaaacttttc aaaattcttg gcctctcgtg ctctctgtct 3197581 aaagtaaaaa ataccgagag tgcgtctaaa aagctgcgga aggtggctgg ctggcccaat 3197641 acatatgatt gtttgatgat tccgtcgagg actgcacata ttattttagc cgtatattca 3197701 ggatcaatac aggcgtcaat cagctttctc tccttcagcc acttaatata taacacattt 3197761 tcttccaccc acaattcgta cagccggaca taggccttgc atttctttaa gactttatat 3197821 gtcggcatgt tcatggcaaa cgaggtgatg tcccacgacg gcttatttat gtaataggaa 3197881 taaagcagtt ctgcagcgtg ttttgcagcc tcgtccaatg tcagcgattt cactgactcc 3197941 cgctccattt gatcaagata ccctataatg atcttttttt tcatctgacg tttttcgaga 3198001 aggtacagca gaaaatcgtc cttgctgaca aaatgaacat aaaatgctcc tttgctgtac 3198061 ccggcggctc tgctgatatc ttctacagaa accggatcat acgctcggtc aatcaacaaa 3198121 ttcacgccag cgtctataaa actttcaaat gttgcttctc ttttaatttg aaatttgttt 3198181 tttttcatat ttttctcctg gcggtaatga ttacccttat cttacaccgg atcaatcttt 3198241 agcggtattt atttctttaa acggttatgc tattcggttt cccaggggtc atttttaata 3198301 ggctaaatga tttattttca tttacatact atccagtcag tatttaattg tttattatta 3198361 taaataaggt ccattggtta tattagtcat ttttttaggg aataggtagg tggtttttcc 3198421 ttcagtttgt gaacaccgag caactatgtg tgaaatttgt tgtactcgcc tccatcatcg 3198481 cgctggcttg tcttttattg cccgcatgtt gcaggaaaac attttataca attggaggtt 3198541 actatgaaaa ctcatgttaa aaaagatttg gacaaaggtt ggcatatgtt aattcaagaa 3198601 gctagatcca ttggattagg cattcatgat gtgaggcagt ttttagaatc tgagacagca 3198661 tcaagaaaga aaaaccacaa aaaaaccgtc cggcaagact agtccgaaca ggcggatcta 3198721 tttacctctg gcttttctat cacctgatct gagttttcac catatcctct attcaaaagc 3198781 aaatcgctgc gctgagcttg aggacaaacg gtgtgtcagc taactacgac agacagccgg 3198841 tgatgcgatc acctcttggc acatgcattg tcataaagag gtgatgcgaa catgataacc 3198901 gtgctctggt aaacagcagc tttgctgaga acaagctgca ttcggtgagg ttttgaaagc 3198961 aaactcgttt atacacggcc gagcttgaaa accttcgcct gtctttagac cactgtgttc 3199021 acctcttcac gacttccttc ttttttcatc ctccagctat tgtacaacgc ataaatcgga 3199081 ctttcagtac atacctattg gtgtaccttt ttgcttacgt ttagcgaata aaaggaggaa 3199141 agccatgtac aaagctgatt ataaacagat tgctgcaacg ccgtcttttc aagctttttt 3199201 aaagcagaaa cgcgctttta ttgttccttc tgcgattttc ttttttgttt tttatttttc 3199261 actccctgtt ttgacatctt atttcacctt tttgaatgca ccggccattg gagctgtttc 3199321 atgggcttgg ctgttcgcca tcgcccaatt cgctatgacc tggatactga gtactgtgta 3199381 ttcccggaga gccgcccatt tcgataagta tgtaagcgct ttaaaagagg atctgaaggg 3199441 tgaacagaca tgaatatgac tgctttttta ttatttttgg cgattgttgg cctgacgctt 3199501 attatcacgt attttgccgc gaagcggacg aaaacgacga gtgagtttta tacggcgggc 3199561 ggcgggctca ccggcgttca gaatggactg gcaattgccg gtgactacat gtctgccgcc 3199621 tcgtttctcg ggattgccgg aatgattgcg ttatatggat ttgatggctt cttttacagc 3199681 atcggttttc tggtggctta tctcgttgtc ttgtacatcg tggcggagcc gcttcggaat 3199741 cttggaaagt acacgatggc agacatgatt gccgctcgct ttaaagaaaa gaaaatccgc 3199801 ggtgtcgcgg ctctcaatac cattgccatc tctacttttt atatgatcgc ccagctcgtg 3199861 ggggcgggcg cgctgatcaa actgcttcta gggctggatt ataccgcggc tgtcctcatc 3199921 gtcggagtgc tgatgaccat ttatgtcgtg tttggcggca tgatcgcgac aagctgggtt 3199981 caaattatta aagctgtttt gctgatggcc ggcacactcg tgatttcgat tatcgtgttt 3200041 tcgaaattcg gctttagcct taataccatg tttgaacaga tgaaaacggc tactccgctt 3200101 ggcgctgatt ttttgaaccc cggaaataaa tacaaggtgc cgcttgagac cttgtcgtta 3200161 aacttggcac tcgtgctggg aaccgccggg cttccgcata tattgatccg gttttatacc 3200221 gttaaggatg ccaagacggc ccgtacatcc gttgtgtcag cgacatggat tatcggtgtg 3200281 ttttacatta tgacggtatt tctcggcttt ggtgccgcgg catttgtcgg ttttgacgcg 3200341 attacggcgg ctgatcaagc gggaaatatg gcggctccgc ttttagcaaa agcgctcgga 3200401 ggagactttc tgttcgcgtt tgtatcagcc atcgcctttg ccaccatttt ggctgtcgtg 3200461 acagggttgg tgctgtctgc cgcctcagca tttgcccatg atatttacag ccagatcatc 3200521 agaaagggag aagcaactga aaaagaacaa atgaaagcgg ccagatgggc ttctgtcgcc 3200581 gtgtcagtgc tctcgattct ccttgcgatt tttgcacaat ccttaaatgt ggcgttcctt 3200641 gttgcactcg cgtttgcggt agccgccagc gcaaaccttc cgctgattgt gtttacagtc 3200701 ttctggaaac gattcaatgc ctcaggcgct ttatggggca gcctgacagg cctgatcagc 3200761 gcgcttgtgc tggtatcgat gagccctagt gtgtgggacc cggccggagg tgctattttt 3200821 accggtgatc cgctcattcc gctatctaat ccaggaatta tttccatccc gctcggcttt 3200881 ctcggcgcgt ggctcggaac ggtgctgtcg tctgataaaa caattgatga agatacgttt 3200941 gcagaaattc aggtgaaggc gcatactggc gtccatatgg aacaggaata aaaaaagctc 3201001 tctttatcga gagctttttc cttacttttt cttctgctcg tcagaaatcg ctttttcaaa 3201061 tacatccttg ccggcagcac ccggaattac agtgtcaccg ataataaagg ttggaacggc 3201121 tgtgatgtca gcctcttcat aggcgtgctt caaggcttgg cgctgcacgt cctgatatgt 3201181 tcttgtttcc agtgctgatt tgaatgatgc accgtctaat cccacttcct cggcgagctt 3201241 cgtcaagatg tcaatatcgc cgatattttg gtcctcctgg aaaaatgcct gaaagacacg 3201301 ggtgttgtat tcatgtcctt tattgtattc cttcgcaaaa tggaagcctt caaacgcgag 3201361 gtctgtatac ggatggggcg agacgtttgg aaaattgatc tcgactccta atttctccgc 3201421 cattggctga attgatgtct gccacatgta ctgtttagaa ggatcattga ccggatcaag 3201481 ctgaggagat gggcttgggc gcagttcaaa cggcatccac tcgacttcaa catcctttcc 3201541 ttttatcgct tcttcaaaag cggcttttcc aacaaaacaa aatgggcaga cgtaatctga 3201601 ataaacttta atgtgtactg tcatgataat ctcctttcat actaaattga ttttaaactg 3201661 taacaattaa agttacaact gttttttaat aaagaagccg atttaggctt ctttcagatt 3201721 gatgacaaaa tcctaaaaag ttttaggatt ttgtcatcct ttcagcgtga ttgaaaaccc 3201781 ttgaagtcta ggaaagccga gcattggagc ggagcgaatg ctctaattcg tgagcaccaa 3201841 cgcacaggct tgacaacgaa tgcgagggtt tgtcgacacg ctgaaagaag cctgtaaagg 3201901 cttcttttat gattccagca aacgctgggc aatatattct ccttttttgc agccgcctgg 3201961 gcatgcgtat aaagcagaac cgattgtttg tgtatattcg tttaacgcat cctttgctga 3202021 aagagccttc agcatcggga taaactgatt gtcgggattt ttttgaaaac tgataaacag 3202081 gagacctgca tccatatagc cggttttcgg atcaagtcct tctgtgtaag agaaagctct 3202141 tcgcaaaatt tgtttcccag tagatttcgc tagactgacg tgtgaattag acggaatttg 3202201 attcagcttc acgggatctg tttccttttt ctgcccaaaa ggcgcccccg agctttttct 3202261 gcggccgaag gtatcctctt ggtccttgag ggaagagcgg tcccatacct caaggaacat 3202321 tttgattttc cgaaaagcca tataggtgcc gcccgtcatc cagtcaggct caccagactg 3202381 aatccacacg atcgagttca tcaacgtgtc atccttcgtg ctctggttgc ctgttccatc 3202441 tttaaacccg aagaggttgc gcggtgtttc accatttttt ccaccgctta aaaagccttt 3202501 gttcacaaaa cggacctcac aagtgccgac cgcttgattt agcaggttac gcagcgcgtg 3202561 aaacgccact tgctcgtcgt ctgcacacac ttgaatgcag atgtccccgc ctccctgctt 3202621 ttcatccagg ttgtcattgg gcatcgctgg aagagcggct aggtgcttcg gttttttgct 3202681 tttcagtccg aagcggtcct ttccgtcttt ttcaaaaaag ccaggcccga atccgaatgt 3202741 gaccgttaag ttggaagggg ataaatcagc agactcacct gtatcctgcg gcggcagata 3202801 ctgatttctc tgctccgctg acattttctt gccagacgtc agcatctgtg tgagacttgt 3202861 ccagtttcta aataacgtaa tgatgtcgct tttgtctttt gctgttacat ccagtgcagc 3202921 aaaatagaca tacgtctgat gggcagttgt gattccggcc tgatgctttc cgtaaaacgg 3202981 aacaatctgc tcctcctctt tttcatcctt tttcgatggc ttagccgcag tctgaacaag 3203041 cggagcgaga ccgccgagac cgctggcacc gatcgcaacg gctgcccccg ccatcgctcc 3203101 ccattttaaa atgtcccgtc tgtgaatttg ttctggcttt ttctgttcat cgctcatgat 3203161 gttacaaaac tccttttata gcacattcgc aatcttcgac atggtttcag aaagagtcgt 3203221 cagcttagtg ctcagctctc tgatttgctt ttcacttaat ttatcataag acgtatagga 3203281 ctgatcattt gttttgtatt ttgccattaa aacttcaaat tcgctgaact ccgtatccag 3203341 tttttccgtc aagtcggagt gatcttttac aagcgcgctt ttcactgttt gataaacggc 3203401 ttcggagcct tccacatttg ccataaggtc aactaaatca attcgtgagt agcgctcttc 3203461 ttctcccgtg attttcgaaa ttccggcttc gttcagaagc tccatcgcgc ctgcaacaat 3203521 ttgttcaggt gttaatttca gtgattgaat tgaaccgtca agctctttta catccttgag 3203581 aagctggtca gctgttgcct tttccccgga aatatcttga tccttccaaa tggccttctc 3203641 aagcttatgg aagcctgtcc atttgtctcc ttcttcaaca tcgttttctc gtgcgtcaat 3203701 tttcggatca agatctccga ggctttcagc gatcggttcg attcgctcgt aataaacacg 3203761 cgctttcgca tataacgttt tggacttttc gatatcgccg gatttcacag cacccgtaaa 3203821 tgcttcagtc gctttgacaa gctggtcact ctgctctttg acatagcctt tatactcatc 3203881 cgctgctttt gccagctgat cgctagcctt tttgccgctc ttcttcgctt ctgtcaggtc 3203941 ttctaaggat gctttcaatg actcggattc tgtcttgatt tttcctgcat ccggtttgtc 3204001 tttttgcgct tctgtgtaga ttggctgaag atgcttttcg atttctgtat attcgaatgg 3204061 atagtcgctg cgaatatcgt tttcaaagga aagccagtag ctgtttaact ctttcccctt 3204121 cttttcaatc tctttttggt ctcctttttc cactgagtca ttcagcttag aaatgatggt 3204181 ttccatttta tttacggatg cggtgatttc tttagtgacc ccgctttttt cagatgaagc 3204241 tttttctttg gttgaagatg tgtcattggc tccgcagcct gcgcacagcg caaggatgca 3204301 tccggctgat acagcgattt ttgtgaaatt cattttgtca gttcctttcc gtttgtaaaa 3204361 tgttttgccg cttctgaaac aagcgcaatc agtaaaaaga gtaaaatcaa catttgcgga 3204421 atcgtgctgt acacagacgg ataaattcct agcaccgata cagacggcag ccagctttct 3204481 gcatcagacg gaagaatgcc cgccagttga aggctgtgaa cgccggttcc gagaaatttc 3204541 acgcacatat acaggacaac cgccattgat agaagaaaaa acggcttcaa tggaatgcgc 3204601 attccgagct tgatcatcag aacaccgacg atgacgagaa cgataagccc tgcggcagtt 3204661 ccgccgatca gttcagtgag cgggagcttc ccgacaagcc cgatgaaaaa gatgaccgtt 3204721 tcgagacctt ctcttacaac tgccagaaat gcaatgagcg caaaggaaag caggcttcgt 3204781 ttttttagtg cctgtgactt ctggatattg attttttctc tccatttatc cattgaggcg 3204841 tttctgtgca gccacacccc gacatacaaa agcatgacag cggacagtac gccggtaacg 3204901 ccgccaagca agaaattgtt ttctccgaat acactggagg agaacagaac cgtgacaccg 3204961 atgccggctg ctaaggaaac agccatgccg gcggacgccc cgccccagat ccatgtcgag 3205021 gaacgcgtaa cccgcgcttt ttttgtcatg gttaatagcg ctccgatgac aaggagggcc 3205081 tccattcctt cacgaaccgg gatcagcgcc gcatcccacc agctgtagct gcttgaagcg 3205141 atcggctcga gcaattgaat catttcgtca atttgctttg ataccttttc aggatggctg 3205201 ccgatctccg ccttcatcag cgccagattt tcctccgatg tcgtataggc ttctttcgat 3205261 tgggacacga catctccctc aacagcgagc caggatgtaa ctaaattgtc gattgcggat 3205321 gacgcttcat ccaattgttt tttttctatg aactgttttg tgtctttcaa gctttgtata 3205381 taggctgtta aggacgccct tgattgacct gaggatgtct ttttcagcac gacagcctgc 3205441 tgataggttt ctaaatgaga cgcaagctct tcaagctgtg ttttgagctt acgtgcgtct 3205501 tgattgataa aagaaagaga aatcatcgcg atattcgcgt ccatttcact gtgagaagaa 3205561 aggttttctt tcttaataga aggttcttct tttttccact tcgccttgaa ggtgtcaaac 3205621 gtttgttgtg ccgaatccat atccccgtct tttacggatt tgatcatttg cttgtttaat 3205681 tgaattaatg cggcgatcgg atcatcttcc gcatgtgccg cagaaccgaa aaccatcaac 3205741 aagctgaata gaataagtgc cagcccccga gccatcatgt tcctcctata attgaaaatg 3205801 attatcattg tataacataa tcatagccag ttcctgtcct ttgtcaatta aaatttgaag 3205861 gtctgaaaac cttgatggac agcaaaaaag ctgtcctttt acagaacagc cctttgaagg 3205921 aaaatgaacg attatcttcc tgttttatac gtttgaattt cctcacgaaa cttgcgtgca 3205981 gcactctcag gatcctccgc ctgactgatg gcgctgatca tactgacgcc atcggccccc 3206041 gcttggataa caggtgcggc attatctatt gtgattccgc cgatgccgac aattggaatg 3206101 ctgatgcctt ggcggcgcac tgcttcgata agagatacac cctgtaccgc tctcgtatct 3206161 tttttcgttt cagtcggata gatcggccca agcccgacat aatccgctcc gtcttcttcg 3206221 gcttgcttca cctcagacat cgtatgggca gaaacgccga gaatcatatc acctatggca 3206281 gctcttacct ctttcgcatt tgcgtcttcc tggccgatgt ggataccatc agctttcaga 3206341 ttcagagcca attccacatc atcattgaca atgaacggaa caccagcttc acggcaagct 3206401 gcctgcgctt tttcagcaaa tttaatccga gcctctcctg tcagcgcatc cccgcctttt 3206461 tcacggaact ggtacagggt ggcaccgcct tttaacgctt tttgtacaac tgtaacagga 3206521 tcggctttcg tattgtttga ccccataatg aagtatacag ataataactc tttcatcatt 3206581 tcccgagaaa tacgagtcat gagacagtca ccctttctat agtcgcccat tcttggacgt 3206641 cttgttcagt aacagttgaa agcttgttca gcaattcaat ctgaaagctt ccagggcctt 3206701 tgtcagccgt ctgctgtgcg gcaagctgag cggcgacccc atacgaagaa atggccgcaa 3206761 tagcagcaaa caatggattt tcttccacag cgcaaaacgc accgacgacg gaagtcagca 3206821 ggcaaccggc gcctgtcact tttgtcagca gcttgtggcc gttatgaagg gtgtatacat 3206881 gtgacgtgtc ggctatgaca tcaacttcac cagttatcgc aatgaccgtg tttagctttt 3206941 gtgccgcctg ctgagccagc cggatgatgt cgcctccacc ttcacccgca tcaacacctt 3207001 tgatcagcca atcggtcacg ccgacggtat gggcaatttc cgccgcattt cctctgattg 3207061 cagcaaggcg cacctcacga atgatgtcac gtgccgattc agtgcggaac ggtgttgctc 3207121 cggcaccgac aggatcaaga atgacgggaa cgccatgttc attagctgat tttcccgcga 3207181 tgatcatcgc ttcgactgac tccttgctca gtgttccgat atttaaaacg agtgcacccg 3207241 caattttcgc catatcggcg acctcttctt ttgcgtacgc cataacgggc gatgcgccga 3207301 gcgcgagcag gccgtttgct gtgaaattcg ttacgacatt gttggttatg ctatgcacca 3207361 gtgggctatg ccggcggaca gccgtaagac attttgctgc tgattgtgca tccatatttg 3207421 catcatcctt tactatcttt tttcgggtcc cataaatacg atttcgtatg ttcgagccaa 3207481 gctctggcgg caaacgacaa gtacctgtcc tttctccaaa taatggcgag gtgccaaggg 3207541 atgaccggat cgacaagcgg aatgactttc actttttccg ggtcaaggcc gcggcagatc 3207601 cgttccggca aaagcccgat cccaaggttg gcggatacca tctcactaat aaaatcccat 3207661 tgtgatgttt cataaatgat atggggccgg aacccagcct tgatacattc cgtcataatt 3207721 cggttgtgca ggacaaaatc ctctctgaag aaaataaaag gctcgtcctt caactcacgc 3207781 agctgacatt ctttctcatc agccagccgg tgggaagggt gaacgacaag cattaaggtt 3207841 tcttttacga ttgtaaacga atgaaagata tcttcgtttg cgggaaggac cacaacgccg 3207901 atatcaagag agccgtcccc gacaccttct tggactttta tagaaccgtc ttcgactagc 3207961 tgaaaggtga cattcggata gttttcacgg aaatcgccga gcactctggg gaaaaacccc 3208021 gatccgatca tcggcggcag tccaatccgt acgtgccctt tcttgacttc cataatatca 3208081 tttaattctg acgtcaggtt ttgaaatgat ttaatgattt cctgcgcctg cacatacatg 3208141 ctatgaccgg catcagtcag ttccacctgc ctgccgtttc ggtaaaacag ttcaattccg 3208201 agctcttctt ctaaattttt gatcattttt gatatcgtcg gctgagaaac ataaagggat 3208261 tgggaagcct tcgtaaaact ttttaaacgg gcgacttcca agaaatatgt taaatggcgg 3208321 atatccatgc gcttcaccct ttctatagac aaaaggaata cttcttattc ttaatatata 3208381 ttttacctat agagagacct tatgtacaat aagtatataa gggaggcatc aatatgaaaa 3208441 aactgttgct aaccgttatt caaatcgctc tgttatttat atttgctcgg ctgattaatt 3208501 gggtgacagc ccttcttcat ataaatattc ccggcagtat aatagggatt gtgattcttt 3208561 tcacattatt gcactttaac attatcaagc ttgaatggat cgagcttggt gcagcgtggc 3208621 ttctcgggga gctgctttta ttttttatcc cgtctgccgt cggagtgatt gaatacggag 3208681 acattatgtc gaaatttggt gtcagcattc tgcttgttgt catcatcagc acgtttgtcg 3208741 tgatggtgtc tacaggaacg cttacacaac tcatcgcaaa gagaaaggag aaaaagcata 3208801 cgtgttcatc ggaattgtaa gtttgttttt aacggttttg gtgtatttag gagcaaaaaa 3208861 ggtatatcaa cgctttccgc gtgtttatac gtcgccgcta ttggtgacgc ccgctgtatt 3208921 agtcggtctg ctgctgctgg tgaatgtccc gtacgagtcc tataatctcg gcggcggatt 3208981 gctgaccgat atgctacagc cggccaccgt ggcattcgcg atcccgttat ataaatattt 3209041 ccctgtttta aagaaatacg cagtggaaat tattttgaat gtggccgtcg gttcatgcat 3209101 cgcgattatt tctaccgctc ttattgcgaa atggcttcac ctcggcaccg gcttaattga 3209161 cagcctcgtc ccaagatcag tgacaacgcc gatcgcgatg aacgtatctg aaatgatcgg 3209221 cggtatgcct gccgtcacag ccgtgtttgt gattttaacc gctttgctcg gcacagtgat 3209281 cggcccgatg gtcatccgtt atttccgcat tgataacgaa attgcgcggg gcgtgctgct 3209341 tggcacaagc gcgcacggag cgggaacgtc aaaggcattt gagctcagct ctgtgtccgg 3209401 cacgatttcc agcgtgtcga tgatcttagc tgcgattatg acgctttgcg cggcgccgtt 3209461 tttgctttca tttatgtaaa aaactgtcct ctcgagggca gtttttttta tgtgcttccc 3209521 cttattgaaa agctggcgaa ttccaatata atgtatttgt ggataccaaa ggaggcaccc 3209581 tgatgcacaa cttgcaggtg aggcggcatt atgccgcgtt aaaaggattt tatttgtttg 3209641 cttttctcgg tacgggcagc ataattccct tactcagtat gtatttaacg aaggaacagc 3209701 atttaagcgg atcacaggtc ggcttgatca tgtcactggg cccgattgtg atgattttct 3209761 ttcagccgtt ttggggcatg ctgagcgact atacgcaaaa aacgaaaggc ctgctggcgg 3209821 tttgcacatc aatcacaggc atcattggat tagcctatat tgcatttgac agtttccctc 3209881 tgtttatttt gattgcggcc tgttttgcag cctttcaaag cacgattatt ccactttcgg 3209941 acagcatttc actaaggtac acacaagaaa caaacggcaa ctacggcgga atccgcctgt 3210001 ttggttctct cggcttcggt gtcgcggtgt ttgccatggg acaggtgacg aaccagctgt 3210061 accccattca cgtgatcttt atctttggct gtgcctttct gtgcattgct gccatattgg 3210121 cttcacaagt gcccggccag cagaaaacaa caaaggtcaa tatccgcaaa ggattccggg 3210181 agcttatcag caacaaaact ttcctcatct ttatgatcat cacctttacg acatttgctc 3210241 caaacttagc gaacaatacg tatttcagtc tttttctgga caaaagcggc gcgtcacttt 3210301 ccgctatcgg cattttattt ttcatcggtg tcatttcaga aattccattt atgagattcg 3210361 cccaaacatt tatagataaa atggggctgc tcaacgtcat tatgctgtca ggcggagtct 3210421 cattattcag gtgggcgctc tatttcacgg cgccttcact atggatcatt tatgcgacgg 3210481 tctttcttca gggagtggcc atcggtttat ttatcccggc ggcgcttcaa tatgtgaaaa 3210541 agattacccc aagacacgtt gaagcgacgg cgctgaccat gtacgccgcc attggcaacg 3210601 ggttcggcaa ctggttctgc acatttgcag gcgggtacat ttttgactac gtgtcgatct 3210661 tcgcagtcta cttgcttttt ggcattctga gcatagcagg ctttggcctg acattatatt 3210721 taatgaaggc tgaaaaaaac aaacatacac ttcatcagcc ggctgttact tttaaaccat 3210781 aatgactata atgaacaaaa gaaaggatgt gcgttatgaa cgggcaagag cgaaacagca 3210841 tttcgaaagg gttgcaggtt gatattgtat tgaaagcaga tcaaaaaaca ggaaaactga 3210901 cgagagggac agtgaaggat attttgacga aatcaaactt tcatccgcat ggcattaaag 3210961 tccgtcttga agatggccgc atcggccgcg accagcagat cgtttctaca taaaaaaaag 3211021 ctgcccctga acagggcagc tttttcatta ttttttctgc agaaggacca ctttcaggta 3211081 gttgccttcc ggaaatgccg aaatcgtttt gaaatcctcc ggcagcgtaa attcctcaat 3211141 gatcgtgtag cgttcatttg tttctttaaa ggcggcatca ataaagcctt tgaacttctt 3211201 catgccaaag gcgctgctgt ttgtagaggc aacaatgaca cccttgtcag cagtgatggc 3211261 gatcgtttcc ttcagcaggt ttttataatc cttggccgcg ctgaaggtgc gtttttttgt 3211321 gcgcgcaaag gaaggcggat ctagaataat cagatcaaag cgcaaatcct tttttgcagc 3211381 atatgaaaaa tagttaaaaa cgtccatcac tttaatgtcg tgcgcttcgt aatccagctt 3211441 gttcacgctg aattgctcga tcgttttggc aagacttcga tttgccacgt cgacgcttgt 3211501 tgttttctcc gctccgccaa gcgccgccgc cacggagaat gcacccgtat aagaaaacgt 3211561 atttaaaacg gttttccctt ttgcatagcg gtctctgatc gccttgcgca catgtctctg 3211621 atccaaaaag atgcccgtca tggcgccttc attcagatcc accgcgtatt gaatgccatt 3211681 ctcttggatg atgatcggga actcgcccct tctccctttc acgaagtcat catcttcaac 3211741 gtattgtcca gccgtgtcga agcgtttctt ctcgtaaatc gctttataat caagatccat 3211801 ctcatccaat gcggaaatca gcatgtcttt aaaggtgtaa attcccttgc tgtaccattg 3211861 aatcagcagg tagccgtcat aatagtcgat ggtgacgccg ccgacaccgt caccctcacc 3211921 gttgaacagg cggaaagctg ttgtatcttg agcctcaaat agtttggcgc gcgcttgggc 3211981 cgcttttgtt aatttgctga gaaaaaatgc ttggtcaatc tgttcatgtt tattgcgggt 3212041 aagcgtccag ccaacccctt tgttttgcag gccgtaatag ccccgcgcga gaaactcgcc 3212101 gccgctctca gacacgatat caacgaggtc tccttctttc atgtgccccg cactccctgc 3212161 gagagcttct ttttcaataa ggggatagcc tttttttatt ttggcagcgt gtgctttttt 3212221 tagggtgagt agcttcatat atgtcgtcct ctttccgttt gctttctctt atggtaccac 3212281 aaaacgccaa gatgtctgca ttgacagaaa ggaaaggttt ttctacgata gacaaaaaga 3212341 gttacgagga ggagcagcat ggcaaaacga attgaccata caggcatcat ggtaagagat 3212401 attaacgcgt ccatcacatt ttatgaagag gtactaggca tgaaattgaa ggatcgcatc 3212461 actcacacga acggtgtaat cgagcttgct tttcttggct ttgaagacgg cccggaaaca 3212521 gaaattgaac tgattcaagg ctacagcagc gagcttcccg ctgaaggaaa agtgcaccac 3212581 attgccctgc tgacggatga catcgcggct gaatatacaa aagcggaaaa aatgaacgca 3212641 aaatttatcg acgaggagat cacaacactt ccaaacggat accgttattt ctatatcgaa 3212701 ggccctgacg gtgagtggat tgagttcttt cagcggtaaa aataaagaac gtacattttg 3212761 tgatgtacgt tcttttttat ctataccaac tgatatacgg ctatacagcc atgaacagca 3212821 taaaatgaac gttattacag ttatcaccac atatggcggg attgtgactg ggcaggcagg 3212881 caagacccaa tgatgcaaag ggagtattaa tgcctaaaaa acagggcatt ttaactcttc 3212941 ttttcgtgtt gggctcataa cggcgccttg gacaaccccc tattctcatg ctccgtcgtc 3213001 gacgcgggca tttttgtcat tttcagccgg tatttctcac ttttttcatt ttgattgtca 3213061 acttttcatt tgatacgatg aacaagccga cttttcttca gcaaaggagg ttttaattgc 3213121 ttgcataaag agattgcaaa agaattactg ctgctcgcag gaggaaaaaa caatattatc 3213181 agcatcagcc attgtacgac ccgtcttcgt tttgatgtaa aggacgagac gaaaattgat 3213241 atacatgcca ttgagaacct gcaaggtgtg cagggcacct ttttccgcta tgggcttttc 3213301 cagattatct tcggagcagg cgtcgtcaac aaaatatata aagaagtcgt tcatgtatgg 3213361 gagaccgcgc cttctgaaga gcctgtccac cagaaaaaag ccagccggaa gctgaaccct 3213421 gccgcagctt ttgcgaaaac actgtccgat atttttgtgc cgattattcc ggcaataaca 3213481 gcaagcggcc tgctcatggg gctgatcggc atgattaagg tgtttcattg gttcgctgcc 3213541 ggcagcccat ggattaaaat gctcgacctc gtgtccagca cagcctttat tttactgccg 3213601 attttagtcg gcttcagtgc tgcacggcaa tttggcagca acccatacct aggggcagtg 3213661 attgcagggc ttttgacgca tcctgatctg ctggacccgt ctatgctcgg cagcaaaacc 3213721 ccgtcttctt tagacatatg ggggcttcat atcccaatga tgggctatca gggttccatg 3213781 ataccgattc ttctttccgt ttttgtcatg agcaaaattg agaagctatt aaaatcgatt 3213841 gtgccgaagt cgcttgatgt cgtgatcatt ccctttatta cggtcatggt gacagggtgc 3213901 ctcgcgctga ttgtgatgaa tcccgccgcg tccatcatcg gccagatcat gacacaatcg 3213961 atcgtctata tttatgatca cgccggcatt gctgccggag ctcttttcgg cggcatctac 3214021 tccaccatcg tcctatctgg attgcatcat agcttttatg caattgaggc aacgctgctt 3214081 gctaatccgc atgtcggtgt caacttttta gtgccgatat ggtcgatggc gaatgtggcc 3214141 caaggcggag cggggcttgc ggtattcctc aaaacgaaac aatcaagcct gaagaaaatt 3214201 gcgctccccg cttctctgac cgcgttttta ggcattgttg agccgattgt attcggggta 3214261 aatctcaaat tgatccgtcc ctttatcgga gcagccatcg gcggtgctat tggcggagca 3214321 tacgtggttg cggtacaagt tgtggcaaat tcctacggac tgacaggcat tccgatgatt 3214381 tcaatcgtgc tgccgtttgg cgccgctaat tttgttcatt atatgatcgg tttcttgatc 3214441 gcagccgtct ctgcttttat agctacattg tttctcgggt ttaaagaaga gacagaataa 3214501 ctggatttat tcgatttcat tcataaaacg ggggatgaaa ggacaaaaaa gctatgaaaa 3214561 ttaaaagaat cttaaatcat aatgctatcg tcgtaaagga tcaaaatgaa gagaagattc 3214621 tcttgggtgc aggaattgcg tttaacaaaa agaagaatga tattgtcgat ccgtcaaaaa 3214681 tagaaaaaac ctttatcaga aaagatacac ctgactataa gcagttcgaa gagattttag 3214741 aaacattgcc tgaagaccac attcagattt ctgagcaaat tatctctcat gccgaaaaag 3214801 agctgaacat caaaatcaac gagcgcattc atgtcgcttt ttcagaccat ctttcttttg 3214861 caattgaacg cctgagcaat gggatggtta tcaaaaatcc gctgctgaat gaaatcaaag 3214921 tcctttatcc aaaggagttc cagatcggct tatgggccag agcactgatt aaagataaac 3214981 tggggattca cattcctgat gatgaaatcg gcaatatcgc catgcatatc cacacagcaa 3215041 gaaacaatgc cggcgatatg acacaaacgc ttgatattac aacaatgatc cgtgatatta 3215101 tcgagattat cgaaattcaa ctgtctatta atatcgttga agataccatc tcttatgaaa 3215161 ggctcgtgac ccatctccgc tttgccattc agcatatcaa agcaggcgaa tccatttacg 3215221 agctggacgc agaaatgatt gacatcatta aagagaagtt taaggatgcc ttcctgtgtg 3215281 ccctaagcat cggcaccttt gtgaagaagg aatacggctt tgagtttcct gaaaaagaat 3215341 tgtgctacat cgccatgcat attcagcggt tctaccaacg gtcagtcgca cgctgagaca 3215401 aacaaaaaac gcttttgatc atctcaaaag cgttttttta tctgatttat tggttgatcg 3215461 ccggattccc aatcgtattc cacttcgtat aggacatgta atggaaatac tcatcgcgat 3215521 acggatgttt tgtattggag ttccaaggct tttctccgcc gcagaagtgc acgattgccg 3215581 ggttttctct tgtttcatta tattgcttcc gccctaacag agtcgatggg gttttcagct 3215641 ttaacatgat ataggtttga gcgttccagc gcggatgaag ttcataccac tgatcataca 3215701 agatcgcatt cagtgcatct tggtcatgca gcacaagaaa gtcttcgtct gggtgttcat 3215761 tgataaagtt gatgactttt tctgtgatgt tttgctttct ccaagactca aaatcaataa 3215821 tcatgatacc tgagttaaaa tacttccctg tatcagtgac gttcatttct ttcaggcgtt 3215881 catgctgccc cgcatcctca acagcggcta cggtgtatgg cgcaatgtct aagtcccata 3215941 gcttagaaat atcctctagg acaagcgcat cacaatcgat gtaaatcatt cgtttgatgc 3216001 tttcatcctt aattaagtcg ggaatcgaaa tgcggtaata cgcggctttt gtaatatggc 3216061 tgctctcaac cgcatgttca tacatgttgg tatccacttc taaaaactca atcggcactc 3216121 cgaatttcaa agtggtttct tccagtcttt ttttgttatc aggcttaatt ccgccatcaa 3216181 tgacgtataa ttttacctct ctctcctgat ccatgttagt caataaagaa acgaacatcc 3216241 cacctaaatg acgagcataa ttatcatctg cgcatgatac gatatgcatg atttcatctt 3216301 tcctcaatgg tattcatctc cctttttgtt gtacaagtta catacccttt ttcaaaaaaa 3216361 taaacacgtt ctccgacatt tttttaaaca gaatgtgtga tacaacaaaa aaggtgtcat 3216421 tttttgaaga tgcgataaag ccaataaaga atgaaaaagc ttgcgattgt gatggcttca 3216481 gccgagacga tataccacgg ccatggcccg agaacatcta agagagagga accgcccggt 3216541 tttttcgtca aatacatata attcgcgcca agccagcgat caatcagaaa aatacagacg 3216601 ccgtacacat taacaagcag gactgtcacc cataacgagc gctggcccat tctgtaggtg 3216661 ccaatcacag ccatcagcag acaggataaa aacacagacc cgtgagaaat aaaaaagagg 3216721 atatatcgga tatgcggaaa tgaaaacata ccgaggtcag gagtggcaag agcctgaatc 3216781 gaactgccga tgccgacaaa aaacaaaaac acaaacagct ttctgctttt tgtcactaac 3216841 ataatagctg acaaatacac cgacaggtca ctaagctgga gaggcaatga agtgcgcacc 3216901 gaccacctgt ccgtggcgac catccatatt tgatagccga tttgcgaacc aagcaaaaga 3216961 aacacaaaca gagaacgcaa aaaccggctg gccctcggct gcttgacctc atcttggaac 3217021 aaaaacaaca gaatggccaa aagggagata atcgctaacg tcactacatg ctctgtcgaa 3217081 aacagatgaa acggatcatg cttatagtcg gattgaacat atttttgcaa aactgcaccc 3217141 ccgttttcgg gtttttgttt attttggcgt tgtttgggct ttttttattc aaccgatata 3217201 tgggcttgaa gttcacacca gactctgtta aaattcgttt catagctaat gattctgata 3217261 atttaaggca ggcctaaaaa atggaacgtt cacatcaaca tcagcagctt cggaaggaag 3217321 aacacgatac actttctaag ctcaaacaaa tgcccgtcga gtcactcaac ctggaagcca 3217381 tttcgatcgc tacgaatctg tatcggtctg cacaaaggct ccgtgtcaaa atggagactg 3217441 aggttctttc tacctataac ctttcttgga ccgctttctc cattctttat gatctatggg 3217501 tatggggagc gctcgaaacg agaaaaatcg ctgagctgtc agggatatct acagctacag 3217561 caagcaacgt gatcaaaacg ctcgaaaaaa agagtttttg ccgtaaaagc atcgacacaa 3217621 gagatcggcg actcgtgttt gtctcaatca ccgattccgg caaacaagcg atcgaagaac 3217681 tctacccgga gtttcacaaa ggggaaacag agctcattgc gggaatgacg aaggacgaac 3217741 agaaaatatt gacagggctg cttagaaagg tagctgacaa tcttcataca acataagctt 3217801 tgacgggaat ccagtagcgg tttgtctccc tgtttcagag agccggcggt aggtgcgagc 3217861 cggcgcacag gcaaacgtga attacctccc caagctttct ttgtgaacct tagtagcaaa 3217921 gaacgggaaa ccgttattcg aatgagcgga agacaatgtc ttcaaccagg gtggtaccgc 3217981 gtgcattgag ccacgtccct tattgggatg ggctcttttt tgtgtttgta aaaaaggagg 3218041 aaaaatgatg agaacatttg agcagctcac agcgtcacaa caaaaagagg tagaaagaca 3218101 gcttcagcta tacatgacag gcgcccacga agtcataccg ccggaggaat taaaggcaaa 3218161 gctcgtgaaa tcaatttcca cgggcacgcc gcttaaaatt aagctcggat tagatccgtc 3218221 tgcaccggat gtacatttgg gccatacggt tgtgttaaat aagcttcgcc aatttcaaga 3218281 aaacggccac attgtccagc tgttaattgg ggatttcaca ggaaaaattg gtgatccgac 3218341 cggaaaatcg gcagccagaa agcaactgac tgatgaagaa gttcagcaca atgccaaaac 3218401 ctactttgag caattcggaa aagtgcttga tccagaaaaa gtcgagcttc actataactc 3218461 aaaatggctg aaaacattga atctagaaga tgtcattgaa ttagcaggga aaataacggt 3218521 agcccgcctg atggagcgcg acgactttga agaacgcatc gccatgcaaa aaccaatctc 3218581 actgcatgaa ttcttttacc cattgatgca gggctatgat tctgtcgttc tcgaaagtga 3218641 tattgaatta ggcggaacgg atcagcattt caatgtcctc atgggacggc atttccaaga 3218701 acgatacaac aaagaaaaac aagtcgtcat ccttatgccg ctcttggaag gcttggatgg 3218761 cgtcgagaaa atgtcgaagt cgaaacacaa ctacattggc attaacgaac atccaaacga 3218821 catgtacgga aaaacgatgt cactgcccga cagcctgatg aaaaagtaca tccacttggc 3218881 gacagactta gagcttgaag agaaaaaaca gctcgtaaaa gacttagaaa ccggcgccgt 3218941 tcatccgcgt gatgccaaaa tgcttttagc cagaacaatc gtccgaatgt atcacggaga 3219001 gaaagcagca gaagctgccg aacactcgtt taaaacagtc tttcaggaaa acagcctgcc 3219061 ggaagatata ccggccgtaa actggaaagg cgaaaaaacg atagcgatga ttgatctgct 3219121 cgtcaagcta aagctcctct cttcgaagag cgaggcgcgc cgcatgattc aaaacggagg 3219181 tgtacgcatc gacggagaga aagtaacaga tgttcacgcc aaagcagaga taagagagaa 3219241 tatgatcatc caagtcggca aacgcaagtt tttaaagctc caataatctg atattccgaa 3219301 acgcttatga cccttcattc ataagcgttt ttttgcaggt ataaagcact gtcttttcaa 3219361 aaacgctctc catcttgcag gaaactcctt tagcatcccg aaatattccc caaccataca 3219421 tttaggggag gtttattttt gatgaaaaag cttttgactg tcatgacgat ggctgtttta 3219481 actgccggca cactgctctt gccggcacag agtgtcaccc ctgccgcgca cgctgtacaa 3219541 atatcaaata gcgagcgcga gcttccattc aaagcaaaac atgcgtactc taccatttct 3219601 cagctaagtg aagcaatcgg ccccagaata gccggaactg cagctgaaaa aaagagtgcc 3219661 ctattgatcg cctcatcaat gagaaaatta aagcttgatg tgaaggttca acgattcaac 3219721 attcctgacc ggcttgaggg tacactgtct tcagcaggac gcgatattct tctccaagcg 3219781 gcgtcgggct cagctccgac tgaggaacaa gggctgacgg ccccgcttta caatgcggga 3219841 ttgggctatc aaaaggactt taccgctgac gccaagggca aaatcgcctt gatttccaga 3219901 ggagacctga cttattacga gaaagccaaa aatgccgaag ccgccggagc gaaagctgtc 3219961 atcatttata acaacaaaga aagcctcgtg cctatgacgc caaacctgtc gggaaataaa 3220021 gtcggcattc cggtcgtcgg cattaagaaa gaagacggcg aagcacttac ccagcaaaaa 3220081 gaagccacct taaaactaaa agcattcaca aaccaaacct cccagaatat catcggaatc 3220141 aaaaaaccaa agaacatcaa acatccagac attgtgtacg tgaccgccca ttacgacagt 3220201 gttccttttt cgcccggagc aaatgacaac ggctcaggta cctctgttat gctggagatg 3220261 gcgcgtgtct taaaaagcgt tccatctgat aaagaaatcc gctttatcgc tttcggcgcc 3220321 gaagagctcg gcctgctcgg ctcctctcac tatgtagatc atctatcgga aaaagagctg 3220381 aaacgaagcg aagtgaactt caacttagat atggtaggca caagctggga aaaagcgtct 3220441 gagctgtatg tcaacacatt ggatggccaa tctaactatg tttgggaatc cagccgtacg 3220501 gctgctgaaa aaattgggtt tgacagcctg tctctgacac agggaggatc atctgatcat 3220561 gtgccattcc acgaagccgg cattgattcc gctaacttta tttggggaga cccggaaaca 3220621 gaagaagttg agccgtggta tcatacccct gaagactcga tcgaacatat cagcaaagaa 3220681 cgcctccagc aagcaggcga tcttgtgaca gccgctgtct atgaggctgt gaaaaaagag 3220741 aagaaaccga aaaccattaa gaaacaaatg aaggcgaaag catctgacat ttttgaagat 3220801 atcaaataaa aaaagacggc acttgggtgc cgtctttttt aatccacttc tttcttaatc 3220861 cccagcattt tctcatctag gtaatgggca atctccgcgg cttctttcag ctcatctgtt 3220921 aattgcttag gaacgtcatt gttcaattta taataaattt tatgttcaag gctcgcccag 3220981 aaatccatcg cgattgtccg gatttgaatt tctgctttga cgtattccac acggttcgtt 3221041 aaattcacag gcatctcaat gattaaatgc aggcttcgat agccattcgg tttgggtgtc 3221101 tggatataat cctttacctt tacgattctc aaatcttcat gctgcttcaa cacattcacg 3221161 acattataaa tgtcagaaat aaaggaacag atgatgcgca cgccggcaat gtcgtgaata 3221221 tgctccttca tttccttcgt cgtaatctca cagccctttc tcattaactt attcacgatg 3221281 ctttcaaagc tttttacacg ggattttgta tgttcaatcg ggttgtgtcc gtgaatgagg 3221341 ttatattcct ggctgataat tgagaacttt gtatcgagcg catctagcgc aaatttataa 3221401 actaataact catttttcca atcttccatt actgttttta aatcgtccat atgtgttaca 3221461 gataaatcca tgttcgtcat ctcctttaac ggaactttat ccgctgtcca tgtactagac 3221521 gtccctgtct gctgcaaggt tctatgaatt tttttacaaa atgcggtcga ttgtaacaaa 3221581 aaaagaccgc atgaaacgag cggtcttttt tattatcgga aatagctgat caataatccg 3221641 atcgagagca ggaatccgaa aaatgtattt gtttgggctg ttgatttcat tgcgacaatc 3221701 atattcatcg gcatttcgtt ctggacgaag cccttcactg cctgaaccgg cttaggcacg 3221761 ctcaaaaaga cgacaaacag ccatgggctt gcggcaccgg taataaccaa gccgacaacc 3221821 cagatataag cgacggcaaa cgacgcagct aacagagtaa cagctccctt atgccccatc 3221881 aaaatcgcca atgttttgcg tccgcctttt ttgtcctctt caatatcacg aatgttgttc 3221941 gacaggttaa tcgcgccgac aagaatcgca atcgggatgg aaatcaaaat gctctgcata 3222001 ttgatcttat ctgtctgaat gaaaaacgaa atcagcacaa acaccgaacc catgcaaatg 3222061 cctgagaata attcaccgaa cggcgtgtac gcaatcggca gcggcccgcc tgtatacagg 3222121 tagccgatcg ccatgccgac aaggccgatc agcgcaagcc accagctgct gctggcacaa 3222181 atatagacac cgagcaaaat ggcaatcccg tatgaggcaa gagctaattg caaaatcgtt 3222241 ttaggcttca ttccgtggcg tacaatggcc cctccgattc cgactgattc tgctgtatct 3222301 aatccgcgtt taaaatcata gtattcatta aataagttcg tcgcgatctg gatccatagg 3222361 caagaaaaca gcatagccaa aaacagcagc agatcaacct tcacataaaa catcgccaaa 3222421 acggttccga gcagcacagg cacaaacgat gcggttaacg tatgaggacg ggttaactgc 3222481 caaaggatct gccccatgct ttctttttgc ggcgctgtct gaccctcacc cttatttgtt 3222541 tggttcatct tcctcttcct ttctattaaa aggcttactt tttttcagcc ggcagcttaa 3222601 taaaaaactc cttttgcttc cttatctatc ataatgactt ctcccttatt tcacaagata 3222661 ccgcaagaag gcgttttctt tcttattata cgcttctcgc cctgatttca ttaggtttct 3222721 gctttcactt gaacgaacag gtacagaaaa atttttttaa gtacattaca ctttttaaaa 3222781 gttaaaaaga tcttttgact ccaggtatct tttcctttat tatgaatcag ctcgaaacat 3222841 tccattcttg cccttgcagg tataaagatt cattttcaaa aacatacgcc gatatattaa 3222901 tttgagggag attagggaaa aaatgaaact ttttgagcat ctgatcgtca aataatcatg 3222961 tgattgtcga aaaaacggga agggaatttt tgatatgctg caattaatga aacagctgta 3223021 tgaaaaaccc gctgtcaagt ggacatgtca tacaggcttt tatttgatga tactgcttgt 3223081 tttgtttttt atgtatggtt ttcacaccgc gaataccggt tcatatattt ataacgattt 3223141 ctaattggag agagaataac tatgaaactt ttacatgcta ttcaaacaca tgcggaaact 3223201 tatccgcaaa ccgatgcctt ccgctctcaa ggccagtcgc tcacgtatca ggaattatgg 3223261 gagcagtctg accgcgcggc tgccgcgatc caaaaacgca tttctgggga aaagaaatct 3223321 cctatccttg tgtacggcca catggagccg cacatgatcg tttccttctt gggaagtgtc 3223381 aaagcgggac atccttatat tccggttgac ctgtctattc cgtccgaacg gattgcgaaa 3223441 attatcgaaa gctctggagc agaattgctg atccatgcag caggactctc aattgatgca 3223501 gtcggccagc agattcagac agtttctgcg gaagaactgc tggaaaacga aggcggctct 3223561 gtcagccaag atcaatgggt caaagaacac gaaacgtttt atatcattta cacttccggg 3223621 agcacaggaa atccgaaagg cgtgcagatt tccgctgcga accttcaaag cttcacagac 3223681 tggatttgtg cagactttcc agtcagcgga ggaaaaatat ttttaaacca agcgccgttc 3223741 tcatttgatt tgtctgtcat ggacctatat ccgtgccttc aatcaggcgg gactttacat 3223801 tgcgtgacaa aggatgctgt gaataagccg aaagtcttat ttgaagagct gaagaagtcc 3223861 gggctgaatg tgtggacatc aacaccttcc tttgtgcaaa tgtgcctgat ggatccgggt 3223921 ttttcacagg atctgctgcc tcatgcggac acatttatgt tttgcggaga ggttcttccg 3223981 gtttctgtgg ccaaagcgct gcttgagcgt tttccgaaag cgaagatttt taatacgtac 3224041 ggcccgactg aagcgacagt ggctgtcaca tcggttgaaa ttacgaatga cgtcatcagc 3224101 cgcagcgaat cgcttccagt gggcttcgcc aaaccagata tgaacatttt cattatggat 3224161 gaagagggac agccgcttcc tgagggagaa aaaggagaaa tcgtcattgc agggccgagt 3224221 gtaagccgag gctaccttgg tgagccagag ctgacggaaa aagcgttttt ctctcatgaa 3224281 ggccagtggg cataccgaac tggcgatgcc ggctttattc aagacggtca gattttctgc 3224341 caaggacgtt tggattttca gattaaactt cacggctatc gaatggagct ggaggaaatc 3224401 gagttccatg tcagacagtc acagtacgtt cgttctgctg tcgtgattcc ttatcagcca 3224461 aacggaacag ttgagtatct gatcgctgct attgtgcctg aggagcatga gttcgagaag 3224521 gaattccagc tgacaagcgc tattaaaaaa gagcttgccg cttctcttcc ggcatatatg 3224581 atcccgagaa aatttatcta tcaggatcac attcaaatga cggctaacgg caaaattgac 3224641 cgaaaacgca ttggcgaaga ggttcttgta tgacgcctta cagctcgttt ttattcttta 3224701 tactgcttgg cattcttctt ctgccgacga tcattctcgg cttaaacgga aaaagatttc 3224761 aagcatacaa catgttcata tctatcatta tattggcttt aattttttcg cacgacttac 3224821 acggggtcat cgcgctgtgc ctgtttacaa tatggcaggt gctcctgatc agcggctatc 3224881 tggcataccg gcagaaagcg aacagcggct ttgtcttttg cggagctgtt atcgcgtcta 3224941 ttctgccttt atttctgtca aaaatatggc cgtttctttc acacccgcag ccgcatcatc 3225001 cgccgcataa cctgatcagc tttttaggga tttcatattt aacctttaaa ggcgttcagc 3225061 tgattatgga agcaagagac ggactgctga aagaacagct gccattgcac cgtctgctgt 3225121 atttcatcct gtttttcccg acgatttcct ccggcccgat cgacagatac cgccggttcg 3225181 tcaaggatga acagaaggct tggacgaaag aagaatacgc cgacctgctg tatacgggaa 3225241 tccataaaat cttcatcggt ttcctgtata aatttattat cggctacgcg atcaatacgt 3225301 acttcatcat gaatcttccc gcaatcacgc acaataagat tcttgggaac ctgctgtaca 3225361 tgtacggcta cagcatgtat ttattctttg atttcgccgg ctacacgatg tttgccgtcg 3225421 gggtcagcta cattatgggc attaaatcac cagaaaactt taataaaccg tttatcagta 3225481 aaaatattaa agatttctgg aatcgctggc atatgtctct gtcattttgg ttcagagatt 3225541 atgtgtttat gagattcgta ttttggatga ctaagaaaaa gtggatcaaa aaccgtatgg 3225601 ccgtctcaaa catcgggtat ttcctgctgt ttatgctgat gggggtttgg cacgggctcg 3225661 cgccgcaata tatcatttac ggcctctatc acgccgttct gatgacgtgt tacaactttt 3225721 tcgagaagtg gaataagaaa tataaatggc tgccgtccaa ccgctggaca accattctcg 3225781 ctattgtgat cacattccat ttcgtttgct tcgggtttta tattttctca ggaaaaccat 3225841 ttcatcacca ccattaaagg agattagaaa gctatggatt ttaaacaaga ggtattagac 3225901 gttttagcag aggtttgcca ggatgacatc gtaaaggaaa atcctgatat tgaaattttt 3225961 gaagaaggtt tgcttgattc ttttggaaca gtagaattgc tgcttgcgat tgaaaaccgt 3226021 tttgatattt tagtgccgat cactgaattt gaccgggacg tttggaatac acctaacaac 3226081 attgtaaatc agctgtctga gttgaaataa tgaaaaagcg ttttttcggt ccaattattt 3226141 tggcgtttat tctattcgca ggcgccatcg caattccatc ttcatggctg acaggcttca 3226201 tcaccgataa gcgtgtgaaa gagtcagcaa cagccttgaa tccgagtatg tttcaagggc 3226261 tatatttaca agatcagatg ctcaaagatc cgacatatct tccgatttac gggtcttctg 3226321 agctttctcg gctggacgag ttccacccat ctaattattt tcaggtaaac aatgagggat 3226381 tcacgccata ccttgtcggc aaaggcggat cccagtcatt gattcattct ttaaacttcg 3226441 ctgcccacat ggatcagctg aagggcaaaa aaatcgtatt catcgtgtct ccgcaatggt 3226501 ttattaagcg cgggtctgat gaacagcatt tcgcgccgaa ctattctgcg ctgcaagggc 3226561 ttgatttggc atttaacgat cagatcgatc ctgaaattaa aaagaaaatg atgaaacgca 3226621 tgcttcgctt taaggctgtg caaaacgatg ccattctttc tgagctgtac aaagcaatgg 3226681 taaacggtca gacgtggaaa gtgaacgcgc tgaagccggc ggcgaaagtg tattacagca 3226741 tgctggaaaa gaaagatctg tattattcaa cgacagaatc atccgggcca aagcgctata 3226801 tctcgcagtc agtaaaggat aagtcatggt ctgaattgaa taaactagcg gatcaatcgg 3226861 gcaaacgcca ctccggttct aacgattttc acatcgacaa ccctgtctat aaaaagctga 3226921 agccgaaagt gcctaagctg aaagggaaaa acaaaggaag atcgtatgcg gtgtcaccgg 3226981 aatatggcga ctttgaaatg atgctcgata tcctgaagga tgcgggcgca gagcctatgt 3227041 ttgtcaccat tcctgttaac gggaaatggt acgattacac gggcttcccg aaaaaaggac 3227101 gcactgacta ttacaaaaag gtaaataaac aaatcagagc gaagggcttc caggttgctg 3227161 atttctcagg gcatgaatat gacccgtatt tcatgaaaga caccattcac atcggctgga 3227221 aaggctgggt gtatgtcgat aaagcaattg acgaatttta taaaaccgga aaagtcactt 3227281 catcctgagc atctcatagg acgcggctgc atatttcctg ctaagatttg taatagtaaa 3227341 ggaatcacag ccaacttaat taagaggtgt tacatccaat gaagatgaca aataatacgg 3227401 ttttaatcac agggggttct gctggcatcg ggcttgaact ggccaagcgc ctgctggaac 3227461 ttggcaatga agttatcatt tgcggacgca gcgaagcacg tcttgcagaa gcgaagcagc 3227521 agctcccaaa catccataca aagcaatgtg atgttgcaga ccgttcgcag cgggaagcat 3227581 tgtatgaatg ggctttaaag gaatatccga acttgaatgt tctcgtcaac aacgccggca 3227641 ttcaaaagga aattgacttt aaaaaaggga cagaggagct ttttgtggac ggtgatgaaa 3227701 ttgaacttaa tttccaagcg cctgtccatt tatccgccct tttcacacct catttgatga 3227761 agcagcccga ggcggcaatc gttcaggtca catccgggct tgcgtttaac ccgttagctg 3227821 tttatccggt gtactgcgca acaaaagcgg cacttcactc gttctcgctt acgctcagac 3227881 accagctccg cgacacgagc gtggaagtga ttgaaatggc accgcctatg gtggacacgg 3227941 gcttaaacca aaaatcacgc gataaacaag gcctgacgta ccggggcatt tcatctgaag 3228001 aatatgttca atatttcttg gacggcttga aggaaggcaa acaggagatt acaaatgaac 3228061 gtgttgaagg tcttcgggat gccactcgcg ccgattatga caggttattc gagcaaatga 3228121 acacgcagga gaattaattt ctcctgcttt tttcatatga atttcttaca aatttgagca 3228181 aacctattgc gattatttgt tgaaggtata caatagaata taattatttt caaataagtt 3228241 tgataatata aacaatttaa cagcagggag attgaccatg actaaacaaa caattcgcgt 3228301 tgaattgaca tcaacaaaaa aaccgaaacc agacccaaat cagctttcgt tcggaagagt 3228361 gtttacagac cacatgtttg taatggacta tgccgcagat aaaggttggt acgatccaag 3228421 aatcattcct tatcaaccct tatcaatgga tccggctgca atggtctatc actacggcca 3228481 aaccgtgttt gaagggttaa aggcttacgt gtcagaggat gaccatgttc tgcttttcag 3228541 accggaaaaa aatatggaac gcctgaatca atcaaacgac cgcctctgca tcccgcaaat 3228601 tgatgaagaa caggttcttg aaggcttaaa gcagcttgtc gcaattgata aagactggat 3228661 tccaaatgcg gagggcacgt ccctttacat ccgtccgttc atcatcgcaa ccgagccttt 3228721 ccttggtgtt gcggcatctc atacgtataa gctcttgatc attctttctc cggtcggctc 3228781 ttattacaaa gaaggcatta agccggtcaa aatcgctgtt gaaagtgaat ttgtccgtgc 3228841 ggtaaaaggc ggaacaggaa atgccaaaac cgcaggaaac tatgcttcaa gcttaaaagc 3228901 gcagcaggta gccgaagaga aaggattttc tcaagtactc tggctggacg gcattgagaa 3228961 gaaatacatc gaagaagtcg gaagcatgaa catcttcttc aaaatcaacg gtgaaatcgt 3229021 aacaccgatg ctgaacggga gcatcctgga aggcattacg cgcaattcag tcatcgcctt 3229081 gcttaagcat tggggccttc aagtttcaga acgaaaaatt gcgatcgatg aggtcatcca 3229141 agcccataaa gacggcatcc tggaagaagc cttcggaaca ggtacagcag ctgttatttc 3229201 cccagtcggc gagctgatct ggcaggatga aacactttcg atcaacaacg gtgaaacagg 3229261 agaaatcgca aaaaaactat atgacacgat tacaggcatt caaaaaggcg ctgtcgcaga 3229321 cgaattcgga tggacgaccg aagtcgcagc gctgactgaa agcaagtaag aaaaaagccg 3229381 gcccattaca ggccggcttt ttttacgctt caattttgtt gaaaaactgc ggcagatacg 3229441 ctttgtgcgc ctctagcatt tcgtctaaaa tctgtttggc cacagtatcg gacgggacaa 3229501 gcgggttaat cgtcatggca aggagcgcag tttgatagtc acctgtaact gccgcttctg 3229561 ccgcgacacg ttcaaaggat ttgatttgct ggacaaggcc gcggacagac accggcaagt 3229621 cgccgacagc aattggctta gggccggttt tcgtcatcac acagttcact tcaactgcgg 3229681 aatcgtctgg aatactcgct attgcaccat tattgatcgt gttcaccggc tgaatgtcat 3229741 gtttatcatt ataaatggag ctgattaagt tacatgctgc atcactgtag taagctccgc 3229801 cccgtttttc cagctgcggc ggtttgatcg caaggtttgg atctttataa agctcgaaca 3229861 gctctttttc gaccttctgt acgacttcag cgcgggtgcc ctccgtttgt gatgcttcca 3229921 gttcgtgctc cagcatctct tttgttttaa aatagtaacg gtgatagccg caagggatga 3229981 cattgagcgc ttttaagaaa tccggttccc attcggcgcc tgagatattt ttcatcgtca 3230041 tcgcgttttt cgggtcgccc atcgcctcga tgacttgctc cttcacactt acgccgtcca 3230101 agaaaacatc cagcccgaat accatatggt tcagtccggc aaattggact tctacgcggt 3230161 ccacatctac atcaagcgct ttggctacgc ccattttgat gccgattgga acattgcaaa 3230221 gaccgacgac tttcttcagg ttggagtagc gaagcaaggc ttctgttacc atgccggcag 3230281 ggtttgtgaa gttaacaagc caagcgttcg ggcaaagctc ttctatgtcc tttgcgatct 3230341 caaggatgac cggaattgtg cgcaatcctt taaacagacc tcccgggccg tttgtttcct 3230401 ggcctatcac tccgtatttt agcggaatgc gctcatcctt tgctcttgcc tgcaaaagtc 3230461 cgacgcggaa ttgggtcgtg acaaagtctg cgtctttcag cgcctttctc cggtcgagcg 3230521 taagatgaat gtcaatcggg acgccagctt tttcaaccat ccgtttggcg agtgtgccga 3230581 caatattcag cttttcttcg ccctcgggga tatcgacaag ccataattca cggacaggca 3230641 gctcatcata ccgtttaatg aacccctcca ctagctcggg cgtatagctt gaacctccgc 3230701 caatcgttac aatcttcaat ccttttgtca tatgcttgct cccctttgct cggtgatttt 3230761 ttcatataac tcaatgatct ctgcagccat atccttcact gtcattgcat tcattaaatg 3230821 atcctgtgca tgaaccatca gaagcgtcat ttccgtcttt tctccgcccg cttcattttg 3230881 gatcagctct gtctgataat gatgggcttt tgacaattct tcagcagcgt cttgaagctt 3230941 tttccgcgct tcttctgcgt caccgctttt cgcagcggca atggcctcca ttgcggagct 3231001 cctaccgttt cctccgtgaa ggatgatttg aaaaatgatt tgttccattt cctcattcac 3231061 gcgattcact tcctttctct acagagccgc ttctttgtca tctgttgctg caggcgtttg 3231121 gaccagctcc agatcgtttt cttctttcag cttctgctta tcccacattc tgaagaatgg 3231181 atagtagaca acaaaggaca cggcaatatt aatggcttgc atgaccgcgc ctgagacttt 3231241 tcctcctgtc gccaagtagc ctgaaaagat cggcggcatg gtccacggca ctgcgatacc 3231301 cgccggtttg gcgacaaggc cggtgctcat tccgatgtac gtgagtgtca ctgtgacaag 3231361 cggcgtgatg ataaacggaa gtaagagcat tgggttcatg acgatcggca ttccgaatat 3231421 aatcggttcg ttaatattga agatggccgg gccgaccgca agcttcccga gctgcttcat 3231481 ttgtttgctt cgggcgcgca ggaacatcgt gacaaccagt gccaatgtgg cgccgcttcc 3231541 gccaatattg acccagatat cgaaaaattg ctgggtgaaa atcttaggaa gctcctcacc 3231601 ggcttggaat gcgatccggt tggcatccat tgcgccgtac caaatcggtg ccatgacgcc 3231661 gccaacaatg tttgcaccgt gaaggccgca ggcccataaa agcattttga cggcttcggc 3231721 gacaaggctt cctccaaggc ttcctcccag aatggaaagc ggagtcccca ataaaacgct 3231781 tacaatatta tgaaggcttt caaacggtgt cgcttcaaca atcagccggg ctgcccaaat 3231841 taggaagatg acggcaaagc cggggattaa cgcgacaaat gacttgctta ccgccggcgg 3231901 gacaccgtcc ggcattttga agactaaatt gcgctggata ataaggcggt aaatctctgt 3231961 ggacaccatt gcgataatca tggcgacaaa taagcctttg cttcccatga gcgaaagcgg 3232021 aatcccgccg ccaaccatga tttctttcgt cgcgccatcc ggcataaacg gcacttgata 3232081 aggtgttgct aataaaaatg ccgcaaggga aatggctccg gccgacaagg catcaacacc 3232141 gtatttctcg gcgagccggt aggcaatgcc gaacgcggcg acaagaccca taatttcaaa 3232201 ggtcgcgtcg actgggtagg ccagtttttc agaccaggag ctgccaaacg tttttgccat 3232261 aaactcagcg tatcccggga tcgggaggtt gccaatgatg aggaaaaagg aaccgatgat 3232321 aatcaggggc atcgtgagga tgataccatc acgcagcgcc tgcaaatgac gctgtcccgc 3232381 aattcttccc gctataggca tgaccttttc ttctaagatc tgattgactt tattcacata 3232441 gcccgcccct ctctatgaca catgtccaag ctgttcagct gatttcagca cttccgcccc 3232501 attgcacgtt ccataatgga cggtattaat gacgtctacc ggaaccccct ttgactctcc 3232561 taattttttg agctgcggaa gcatgtaacg gacttgcgga ccgagaagca atacatccgc 3232621 tttatcgata tgattttgta cagaatcgcc tgaaactgcc caaatggtat agtcttttcc 3232681 ctgttcctgc gcactttttt ccatcttgct caccagtaag ctagtagaca tgcctgctgc 3232741 acaaacgagt aatatattca tgtaaaagac cccctagagt ttgatcaatt ttgtaatgtc 3232801 ctgctgttgc tatcatcata ttatgaaatc gctttcataa acactcaggg tttttccgca 3232861 ggcaacggaa aaaaggtata tacaggctgt cagctcagca ttttttggtc aaacacatcc 3232921 gaaagctctt gatatgaacg gcatttgatc agctggttca tcgccgccgg gtcatccaaa 3232981 atgctgccaa gcagtttata catgctttgt aaatccgctt tgttctcctt ttcgacacaa 3233041 agcagacaga caaattgaac tcgctgactc tcccaatcga tcggtttttt gagcgtacaa 3233101 acggcccaaa acgttgtttt cgtctgcgga acaagcgggt gcgggatggc aacaagattg 3233161 ccaaaacacg ttggcgacat gtcttctctt tcaaaaatgg aatctatgat ttcttcatcg 3233221 gcaaagccgc attcgaccac tttctgccct aaaaattgaa tcacttcttc ttttgagcgc 3233281 agatcctcct gaaaaaaaac gagttctttt tttaggtagc gattggcttt ttccttttca 3233341 tcactcagaa tagattctat ttttgtaaag tcagttccgc ctaagatggt gttaaccttc 3233401 agtactggta cagggagctc ttttttaatc ggaatggtgc tgatgacaaa atcaattgat 3233461 tcgtaggaca tttgatcaag actataatac tcagccgttc caagaatatc gagccgcttg 3233521 ccgaaatggg aacgcagttt ttcgcgcaga agctgggcgc ttccggctcc cgatgcgcat 3233581 acaatgatac agcgtttcgg cgggctttct gttttttttc gttcaatcgc ggcgccaaag 3233641 tggagagcca aatatccaat ttcgttttca tgaatctcaa tacccgtttg ttcctttatc 3233701 acgattccgg caatgatccc ggcttcaaaa gcgagtggat aatgttcctt gatcgctgcc 3233761 agcatcggat ttcgaagatt catgccgtat cggttgcggc tgatcgccgg cttcatatgc 3233821 agtgccaagc cgattttcag ctctttgtca tgcaggatgc caagcttcag ttcacgatca 3233881 acagctttga tcatggcaag tgtcagctga tcggtttcct cttctattga aaatgtgtcc 3233941 tctccgcatt gtgattgtgt cattcgtttt gtgccaagga gatgcatggt gatgtaggcc 3234001 gtctcgtctt tcggaaacgt aacggaaagc tttgattcca gctcttttac gatggcttct 3234061 gcagcctggt actccttttg atgcaggata tgatccatat ctttcgggaa aagagaaaca 3234121 tagttttccg ttctgatccg tttacaggcg atagcgatat ggataatgag gttattcagt 3234181 cccatgttgg acagagggat gcggtcgttt ttcatttttt tcaagatggc ggaacggatg 3234241 atctcaattt cttcttttgg caaaatatca gccttttcat ttaaaacatc tatctccgtt 3234301 tctctttcat caacaatgta ctccgccatg cagtacctca tctgcacctc gtccccgcgc 3234361 agcttgaagc cgtaattcgg acgtgtttcc atgacgatgc ggtaaggcag cagacgtttc 3234421 tttacttcct ttaaatccgt ttggagtgta gattttgaga taaatagttc ttcagcaagt 3234481 tcatcgagct tgagataatg gtccgccagc agcagacgtt tcataagata ggccattctc 3234541 tcctccggca ataccggcag gccctttttt tgctgaaatt catcttgcag cagtgttctg 3234601 aatacttgct cgtcatcaat gcggagcttg tagccggagc ctcttacaga ttgtacaaag 3234661 gcaccgtggc cgcttagcac accttgaagt tcctttatat cattgcggac tgtccgcgtc 3234721 gttacgttta attgcgcggc aaaaaacgaa cttgtcaccg gggcttcagc cgccatcagc 3234781 aagcgcagaa tatcacgtag tcgcccatga agcatgagaa aaacctccta actagtagat 3234841 gcagggattc agtgaatagg cagaaaggat gatgaaggga tgcgaaatgt atataaattc 3234901 tataatggag agaatggcaa gtcaatgaac atccggagga ctagagggaa aactgaccta 3234961 taaaaaaaca gccgggatca gccggctgtt ctagatgcgg acatattctt ttgtttagac 3235021 gccttgcggt ccttcatgat ttttcgaaca atcgggtaaa tgaccggcgc ccatttgata 3235081 acggttttga tcatcttttt caaagctccg attctccctt cttttttctc aaccattccc 3235141 ctgattgcct cttccttaaa catgctaacg cgacacgtac ctgtttcccg tcacccagaa 3235201 acgccatgga taatcgcgtg cctccccgct gttgtcaatg ccgatgcgcg ggccggttga 3235261 aattgcttcc ggtgtgtacc cgctttcgat gtaaagcggc tgttccgtga tccagcgtcc 3235321 gtagtcattc atcgtgacgc caagcgcttt cgtcagcttt cctggtccgt ttgtccattc 3235381 cctcggactc ctgcccggcc ttctctcctc cattaacagc tggccttcat gcggctcaat 3235441 cgccctgatt aatactgctt gcgggacatc ctcttccgcc gcaacgacat tcagcaatgt 3235501 atgggtgtgc atcacgtatg tatatacccg cccagcttct gcaaacatga tctcagtccg 3235561 cttcgtccgg cggttgttaa agctgtgggc cgctctgtct ccagccccca tataggcctc 3235621 tgtttccaca atatagcctg acgctgtgcc ttcgtctgtt tcttttacaa gaaggcagcc 3235681 cagaagcgat ggggcaagct caagagcggt tttttgataa aacgtgatgg gcagcggatt 3235741 tttttctctc gtcacgaatc gacctctcct tttaccgatt tttgtacatt gtaccattcc 3235801 cgaagcagat caaaaaaaac ggctgtttta aaatctttcc attcagggaa tattgttacc 3235861 gttcaaaaaa ggagggccaa ccattgaaag atgatcatca aaacaagcag caccaatcaa 3235921 atgcccaagg gagcgaggaa gcgttttctc ataagacatc cgggaaaaac gagtcagagg 3235981 ataccttaac gaataggcag gggcatcctg ttactgacaa ccagaatgtg agaaccgtcg 3236041 ggaatagagg gcctacaaca cttgagaact atgattttct cgaaaagatc agccacttcg 3236101 accgggaacg catcccagag cgggttgttc atgccagggg agcaggtgca catggatatt 3236161 ttgaagcgta cggaagcttc ggagacgaac cgatttcaac atacacaagg gccaagctct 3236221 ttcaggaaaa aggcaagaaa acaccggcat ttgtccgttt ttcaactgtg aatcatggaa 3236281 aacactcgcc tgaaacattg agagacccgc gcggttttgc tgtaaagcta tatacagaag 3236341 acggaaactg ggatttggtc ggaaacaacc tgaaaatctt ttttatccgc gacccgctga 3236401 aatttccgga tcttgtacac gcatttcagc ctgatccagt gacaaacatc caggatggtg 3236461 aacgtatctt cgatttcatt tctcaatctc ctgaagcgac acacatgatc accttcttgt 3236521 tttcgccttg gggcattccg gccaactacc ggcaaatgca gggttcaggc gtacatgcct 3236581 ataaatgggt gaatgaggag ggcaaggccg ttctcgtgaa ataccatttt gaaccgaagc 3236641 agggcatccg caacctgaca cagaaggaag cagaagagat tcaagggaaa aactttaacc 3236701 atgccacaca ggatctatat gacgcgattg aaaatggcga ttatccagag tgggaagtat 3236761 atgctcaaat catgagcgat gatgagcatc ctgaactgga ctttgatcct cttgatccaa 3236821 caaaactgtg gtataaagac gatttcccat ggaaaccgat cggcaaattg gttctgaaca 3236881 aaaatccgga aaactaccat gcggaagtgg agcaagcttc atttggaacg ggagtgcttg 3236941 tcgacgggct tgatttttca gacgacaaat tgctccaggg gcgtacgttt gcctactctg 3237001 atacgcagcg ctaccgtgta ggcgcaaatt acctgcagct tccgatcaac tcgccgaaaa 3237061 agcatgtcgc caccaaccag gaaggcgggc aaatgcaata tcgggtcgat agagcagaag 3237121 gacaaaaccc gcacgtcaac tacgagccat ccattatggg cgggctgaag gaagcgaagc 3237181 aagacggaaa agaccatacg ccgcatgtcg aaggtgatgt aaagcgtgaa gcgattgaca 3237241 gaacaaacaa cttcggacag gctggagaaa cgtaccggag atttactgaa tttgagcgga 3237301 acgaattgat tacgaatttg gtgaatacgc tttctacgtg ccgaaaagaa attcaggatc 3237361 aaatgattga gaatttcaca aaagctgatc ctgactacgg aaaacgcgta gcagaagggc 3237421 taaaaaaggt ctccgaaaac aacagcaacg ggccgatcgg cacaactgaa acggaacagg 3237481 ctgcaaagca ggctgaacag gagagtcatc cgtctgatcc gtattaacaa cagcgaacag 3237541 ggctttttta gaagccctgt ttttttattt ttctattgaa acgctttcaa taattgtgtt 3237601 gtacttggaa ggaaaggggt ggagagatac gatggaatta cagcaggact tgattcctca 3237661 gaaaaaaaca atcggcgctt tagatcacgc cgttttttta tgcatggtat tttgtttctg 3237721 gttttcaggc tatatttacg ttcctgtatt cagtctgtat ttggaggatc tgcacttttc 3237781 atatggcgca atcggcatca ttctcggcag ctacggggtc acgcaaatcc ttctgcgatt 3237841 cccgctcggc cttttgtcag acatcctgtt ttccttgcgc aagcaattgt taattgccgg 3237901 gttcggcttt tccgtcctca gcagcctgct ttttctgatg tttgattctt tcttcttcgt 3237961 gctggccgcc cggcttttcg cgggaatcac tgcttctacg tgggtgatgg cgaccatttt 3238021 atacgcacat tatttcaaca atggcaatgc atcaaaagca atgggcatca tgcagttttt 3238081 taccgtcatg cctcagtttg ccagcattgt gttctgcggg ctcgccgcag cccatttagg 3238141 gaggcaggtt cctttttgga tggcgctggc agcttctgcc gcaggtctgg tgatctgctg 3238201 ctttattcag gatccgtctg ctcctcccgc aaaccgtggc accattcgtg tcaatcagta 3238261 catcaaagat acattgcggc tgccaaagct gaagcttttc accatcctgt ctatgacggc 3238321 ccatgccgta ttatttatca cagtgtttgg ttttacgccg ctttacatga atcagctcgg 3238381 aatgggcgac gcggagctgc tttgggtgat gagcgccttt ttcctcccac acgcagccgc 3238441 cacattaagc tttgtgtttc tgcgctttac aagccgtatc gcttactccg tgatgctcat 3238501 tagtttcgct gtcaccgggg tctgtttgct atatgttcct tttttagctg cattgttcac 3238561 ggtttgcatc acacacgcct gtattgggct ggcgctcggc ttcgtttttc ctctgctgct 3238621 aagccatgtc gtcgaaatca gttctgcccg tttaaaaatg tcagtgatgg ggttttacca 3238681 atcattttat gcgctaggca tcttcctcgg gccccttctt gccggaaaaa tcgcacagct 3238741 tatcgggctt gcgggagttt tttatggagc cggttctctg gcatttgccg ccttttttgt 3238801 gatgctcgcg caaaaacgta acatgatcaa ttaatagctt tcataccgcc ggaagcgcca 3238861 cacagaaaac acggccagaa gcatgatgca cagaatggag aaagtgagtg accatccgaa 3238921 aaaatctgcc cgctctccat gaagaaggat atgctccgcc tgcttgcaaa tctcagccgg 3238981 aagccacttc gcaccatctg gaaatagtga aacagcaaag gaaacggctg ctgtgagccc 3239041 gatcccgcaa gccgcagctg ctccgacaga ccggaatatc gtacttccgg caaggccggc 3239101 ggtcacaata aatatcaccc aaagagcgta aaggccaagg cttgcggcaa agcggctgaa 3239161 tgatgcgtcc tcaaacagca gccggacgta atagtaagca agcccgtatc cagctgcaaa 3239221 cgacataatg ccgatcacgc tttggatgag ccatttactc acgatataat gggctgccgt 3239281 cacaggccgc gacataatca gcgctgttac cccttgattt ctttcattgg ctacactgcc 3239341 catcacgcta aagatgacca gagccatgcc aagcgtgttg aattgagaaa gcgtgctgac 3239401 catcacttca gacccggagg gcatcgtaaa actgattttc atgccgtcag gaaggttccc 3239461 tccatgtgcg atgatttccg gcatataata aatggtcagc ggctgtgtca gcccgacgat 3239521 catcatcgca atcggcagcc aaatcagctt gccgcttttc catccttcca gccactcctt 3239581 ctgcaatagc gccatcatca ccttcatgcg tgcaccacct ttagatagac gtcttctaga 3239641 gactccgttt tctgttcaaa gcgggtgacg gtcaatccct ttcggataca gtcacttaat 3239701 aatgaccggc cagcgtgtat atcaggcagc tcgaaaaccg cttgggacgg attcttatag 3239761 acaatagctg agacgtaagg cttctcttca agccaacctt ccagcttctc tttcactgaa 3239821 agggtaaaaa cgttcgtttg ctgctgttgt ttcagctcct gtaactcgcc tttccatgaa 3239881 atctcaccgt ttttcataat caccacttga tcacacacct gttctgcatc gtgcaaaaca 3239941 tgtgtagaaa acagaacggc catatgcttt ttcagctccc gcatcatgtc cagcacctcg 3240001 aaccgtcctg tcggatcaag cgcagacacc ggttcatcca atatcaaaaa cttcggttta 3240061 tggagcagtg cctgtgccag accgagtctt tgtttcatgc ctcctgaata gcccccgatc 3240121 cttttgtgcg ccgcttcgtg caaaccgaca aattccagca tctcgccgat tttctcttgg 3240181 cattttctct tcgaaaggcc ggacagtctc cccgcaaatg tcaaaaattc atttgcggtc 3240241 atccacgaat aaaaagcagg atactgcggg aggtacccaa tcaaacgccg atccagcttt 3240301 ttctctccta acagctttat ggttccagag gttggcgaaa gcagtccggc cagcatttgc 3240361 agagtcgtgg ttttgccggc tccattaggt cctaatagtg cgacacactc attttcattc 3240421 acgtgaaaac tgacattctt tacagcttca tggtgcctgt acgatttgca taatgattca 3240481 atagacagca tatcggctta cctttgcttt ctgccgacgg tgaaaaataa aatcggcccg 3240541 ataatattga tacatacgat gattgcagcc cacatccact ttggcccgtt cgtccgctct 3240601 tcttttatac agctgataag ggcaaacacc gccaaagcca gctgtaatac aatcagcggc 3240661 aaaatcattt cccaagaaat attcattgct tgatccccct tttcttccga tccggcctaa 3240721 tgacaaaaaa gtaataacaa atcagaggca tcggtgcttg aatcaatccg acaatccccc 3240781 aaacccatgc catgtgatta cgttttttcg catcaataaa taaaaagatt ccctgcgcca 3240841 atacgatgag acaagccgca accgttatga taatttctgt ttgtgtcatc cgcgtttcac 3240901 ctcgcattcg ccgagatgcc tttttttctc agccgcaatc aaaatcggca gcaccgcaag 3240961 cacacaaacc tgaagcacaa taaacacagc aggagcttga gtgaaagcta agattgcagc 3241021 actcacaacc atcagcgcgc agaatacaaa taaaatgatc tcttgaagaa gtttttttct 3241081 gtattcagct ttcatttgtg acagctggtg aagcagttct ttttgattcg gtatagaggg 3241141 attggctgtt tgatcaattt ttttccattc tgactttaaa tgatcagaaa gcttttcttt 3241201 attcatcatc ccactccttt ctgatttgct ggagcccttt atgaactctg gactttacag 3241261 tgccttcttt gatttgaagc atcaccccga tttcagcgta ggtatagccg tagtaatgcc 3241321 ttaataaaac cggtgtgcgc agtttagggt ccagctttga aaacagatcg agcgtttcgc 3241381 tccactctgc ccctttcgcc gacacgtccc acttgatctt gcggattgtt tcctccgtaa 3241441 ctgtctgatt ccgtttccat tctctctttc tctttttctg gtgatcgaga tagagccgcg 3241501 atgcaatgga gatcagccat gtggagaatt ttgaacggcc ctgaaagctt cttaaatgga 3241561 tgtacccttt cagaaaggtt tcctgaacaa gttcctcgct gagatcgggg tgaagggaaa 3241621 gctttaacaa gtatttatat aagaaagaat agtgatagtg gaaaagggct gtaaacgcct 3241681 cgtcgtttcc ctctttcgcc tgctggatca gccgctgttc ttcttgtgta tccaatgacc 3241741 gtgatccccc cttttttgtt tttctgcctt atgagacgac accggattca aaagcgttca 3241801 tcttttttac aattcttttc agccattgac agatcaggct tcccggccgt ttggctgcat 3241861 atccttattt gtaaaccccc ttatagtctg ttaagctatg actttatgtc gatttcaaaa 3241921 aaacatccaa tatggaggac gatgcattga aagtagaaag gcgaacgatt gaatatattc 3241981 cgaatgaaga aagacatggt aaagcgaaag atttatttcc cgtatggttc ggggctaata 3242041 tgcatatcac cacgttagtg accggcacga ttcccgttgc aatgggactt aatctgtttt 3242101 ggagtgttgc cgctattatt tgcggaacct taatcggtgc catatttatg gcttctcatt 3242161 ccgcgcaagg ccctcagcta ggcatcccgc aaatgattca aagccgtgcc caattcggcg 3242221 taatcggagc gattcttccc ctcttcttag tcatgtttat ctaccttggt ttcttcgcaa 3242281 gcagcacgat tctggcggcc ggaaccttaa gcagctttgt tcccatcccg ggatcatgga 3242341 gcattatagg cttaagtgcc gtatgttttt tactcaccat tttcggccat gatttgattc 3242401 acaaaatgca aaaaatcctt tcttggacct cttttgctgt attttttgct gcaacgattc 3242461 tcatttttca attgccgatt ccggcaggca gctggatacc cggagcgatt gatctgccaa 3242521 ttttcctagt ggcagtcagc gcagttgcga cgtggcagct tgcctacgcg ccgtatgttg 3242581 ccgattattc aagatatctg ccagttaaaa caccggcttc aaaaacattt tggtacagct 3242641 atgcaggtac atctgtcagc tccatctgga tgatgctgct cggcgcattg ctgacaacct 3242701 cacttcctga ctttacggca aactcaggca gccagattgt ccaattgttc ggtcccttct 3242761 cgtttattat gctgatcatt gtgctatttg ggcaaatggc aatcaatgtt tttaacctgt 3242821 atggggcttt catgtccacg acaacaacgc tggagccgtt tctgaaatta aaagtcacgc 3242881 ccaaagtcag aatcatcatg atcctgggtg tcacgcttgt cggcacagtc ttaagcctac 3242941 tgggacagag caattttatg gaactgtttt tgaattttat ctttttcatc agttatttct 3243001 taattccgtg gacggcaatc aatttagtcg attactactt cgtccgccac ggaaagtatc 3243061 aagtcaaagc catgttcgac gtaaacgggc cttatggaaa ggtcaattgg atcaccacaa 3243121 ttgcgttcgt tctgtctatc ttgctggaaa ttccgtttat caacacaagc ttttacatcg 3243181 gaccgcttgc caaaatgttt ggcggcggag acatcgcatg gattatcggc ttggccgtgc 3243241 cttctgtgct ttactatgta ttaatgaaac cgcgtctgaa aaaacgggcg gggtatcaag 3243301 aaaagctgtc ttctctctga agacagcttt tttatcattc aaatcgtttc cacacgcggg 3243361 gcaggatgtc agatagctca tgagcgagca acgtatgagc ggagtgctcg tccgtccaga 3243421 gctcggcgca cgcaccatgc aaatagaccg cgtttaatac ggcgtgcttt ggatcttcat 3243481 ggcagcagag catccccaat atcatgcccg tcagcgtgtc accggttccg cccttggcga 3243541 gcgccccgtt tccggttgga ttgagccagc agtctccatc aggaaacgcg atgacggttt 3243601 ggtttccttt taacacaatg acagtctgca gctgagccgc ccattccttt gcatattccg 3243661 ctcttttttt ctgcaattcg ttcacgggca cccctgtcat tcggaaaaac tcgcccgggt 3243721 gcggcgtgag gatgacgggg ccctcccgtt tcggatatgt gcgcttcgcc agcgctccgg 3243781 catccaaaat aacaggacaa tcagccgtaa gcacatgatc gactgcctgc tgtacgcttt 3243841 ccgtttgcgg aaggcccggt ccgatggcaa tggcccggta cgtctcttca agctgagcat 3243901 ccgccgcctt tttccagccg tcacgccaat aggtcgcctc gggcaaaaca ggaacaatta 3243961 gcgggattac gttttctgat gtaccgatga caagcttgcc gagaccgctc cgcatggccc 3244021 caagccctgc aagcagcgct gctcccggca tgtcgtcact tccagccagc agcaaagccg 3244081 taccgtacgt gcctttatgg ctctccgcat ctctttcagg aagcgtggcc cttacatgct 3244141 cttccgtcca aaatggaaca ttcatctcta tccctcctct gctttctttt cctatttttc 3244201 ctgtcccttt tctttttcaa acaaaaaaga cagcctttta gggctgtctt ttattttaca 3244261 ggaacatcaa ggtgatacag gcggcgatat cgttcgtttg ccgccagcag ctcctcatgg 3244321 gttccttcca tttctgtttt gccgttttcg agaaatacga ttttatcggc tgcttccact 3244381 cccgcgagat ggtgtgtaat ccataaaatc gtttttcctt tcagcacctc aaacaccgtt 3244441 tccatcaatt cacgttcggt aataggatcg aggccgactg ttggctcatc gaggatgatg 3244501 atcggtgtat cctgcagcaa aatcctcgca agtgcgatcc gctggcgctc tccaccggaa 3244561 aaacggatgc cggtttcttg tacagaggta tgatatccgt caggcaatga ctcaatgtag 3244621 tcatgcagct tgacctgctt tgcggcgcgg cgcacatcct cgtcgcttgc ttctccgttt 3244681 ccgagcctga tgttgttcaa aatgcttgta tcaaacaggt gcggtttttg atttaacacg 3244741 gccaccgcat ccgcaatctg atcctttaac agcgctgtct ccactccgtt taacgtcaca 3244801 gaaccggagt ccggtttcaa ggcgccttcg attaatgcaa gcgatgttga tttcccagag 3244861 ccgcttcggc cgagcagcgc cattttttct ccttggcgca gcgtaaagga aaagttgtgc 3244921 agcacttggc tgctgttgtc ataagaaaac gtcacatcac gaaaggccaa ggtgacatct 3244981 tgaagatcga gaatttgatc ccctgattca gtttgtgacg cctccggctg aggagccaca 3245041 ttgttcatgc gtctgataga atcctgatag cccggcactt cgcctaaggc atccgaaagc 3245101 ggcaaaaagg cttccgtcaa cggaaacacc actagcacaa aagcggcaat catcgtttta 3245161 gcgagctcgc cgtccgcttg ctgtcccgct gtccaaaaca gcatcagcaa aataaggcca 3245221 gcgacaaggc attgcgcagc aaagtcccgc catcttgtaa agcgttgttt tttccgttca 3245281 agctcaaacc aatcacgttc ctctttttca taagcatcaa taaaagcatg ccggcgtccg 3245341 ctgaacatcc agtcgctgac acccatcaca gcatctgtca gacggctgta cagcacattc 3245401 cgtccgcttt tcagcttcgc attcttcgct ctcgtcacga gcaaagacac aaccggaaac 3245461 aatacaacaa gaacaaacaa atacagcgca agcaatatgg caaacggcca agagaagaag 3245521 ccgagcgcta tcactgacac agcatacagg agcaaggctg agatcgcagg aaaaatcgtt 3245581 tttaagaaag catcctgcaa atgctcaata tcctcagaca aaatgccgag catatccccc 3245641 gtgcgaaaac gggaacgcag catcaaagca cccggctcaa gcatattgta aaggcggacg 3245701 cgcatgtcag atacgatttt caaaatgatg tgatggccga cgagccgttc cacatatcgc 3245761 gacacagagc gcgcaatccc aaaggtgcgc acagcgacaa tcggcacata aatgagcaga 3245821 atgttttccg gccttgtcgc cgctttagaa atcaaaaaac ctgaggtgaa catgagaaaa 3245881 gcagcagaaa aaatcgtcac cgcacccaaa aagataacca gaacgaacag gcgggcattt 3245941 tgcttgatat acggcaaaat ccattcttct ttcttcatgc tctttccccc agttgtgcct 3246001 tcacgagttt ggtatacaca ccgtttttct ccagcagttc attgtgagtc ccaatttccg 3246061 caaccctgcc cccgtcaagc acgataattt cgtccatatc gagcatccag tgaaggcggt 3246121 gagtcgcgag aaagacgagc ttatcctcaa ataaatccag catcgtttct tttatttcat 3246181 attctgtttc gatatcaaga tgggcggtcg gctcatccag cagcaggatc ggacggtttc 3246241 ccaaaaaggc gcgggccagc gcgacacgct gtgcctggcc gccgctgagc gcccggccgc 3246301 cttccccgat ccgcccctct aatccgtcag gaaggttgtt caccagctcc gtcagtcccg 3246361 ctgaggcagc agcacgtgtt gtatcctctg ccgaagcgct tggatggtag aagcgaatgt 3246421 tgttgccaag cgtatcatca aaaatgtacg gatgctgggg aatgtaaaga aggttcttct 3246481 gccagctgcc gtcctgcaaa tgggaccggc ttgtaccatt aacctcaatc atcccgccat 3246541 ccggctctaa aaatccgccg agaatatcaa ttaatgttga ttttccggcg ccgcttgcac 3246601 cgataatgcc gatttttttc ttgcctttga atgagagatg aatatcagac accgaacggc 3246661 cgactgacac gcctgacagc ttcagctcat cctgatcgga ccaagcttcg agctgaagcg 3246721 gcgtctcttc tttaaaacca ggctgcgaca aaatctcttg aatggttttt cctgcttcct 3246781 ggccgttcag cgttgcatga taatcattcc ccacttcccg caccggcaaa aaatactcag 3246841 gcgccagaat aagcgccgtt aaagcagggc caagcaaaat atcgccgtca atgaggcgca 3246901 ggcccagaaa tactgcgact gtcgccaccg acagcatcgt gaaaaaatcg agggcgaatg 3246961 atgacaaaaa cgccacccgg agtgtgctca tcgttgcctt gcgataccgc tcactcacat 3247021 agaaaatatt tttgctgtgt gacttgctca aacctaggaa acgcaatgtc tccagcccgc 3247081 gaagagaatc aacaaaatga ttggaaagtc tctgatagga tttccactga cgatccgctt 3247141 ttctctgcgc gacaaggccg aggagaatca taaagatgat cagaatcggc atagcagcga 3247201 ctaaaatgat ggctgatgtc cgatcctgaa aaaacacata aatgacaact gccgcaggca 3247261 caatcgccat gctgaccatt ttcggcagaa acagctccag gtagcggcgg aactggctga 3247321 tgccttccat cgccagcgtc accatttgcc ccgtcccctc tttctttgca aagcgggggc 3247381 ctaatcggaa cagctgatca agaaaacttt tcctcaaatc tgctcctgtc cgggcggcgt 3247441 attgatagac gattttctgt cgcgccaccg tcatcccgtg ccgggcgata aaagcgatga 3247501 ggaaaaagcc gatcaccggt aaaagggagg taatgccctt cccgttgaac agtccggtta 3247561 cggcctcact cagccactct gcctgcataa taatggcggc tgtctgaatc aacgttaaac 3247621 aagtaatcaa ggtgagaatc cgcttcattc ctttatatcg aaacaggtct tttcccatta 3247681 ataagtcata ggctccttat ggctgacgcg cttccggaag acataatagc tccagatctg 3247741 gctgccgatg acgaacggca atagcgttaa tgctgcaatt gacatgactt taagcgaata 3247801 atctccagaa gaagcgttag ctactgttaa atcgtatgcg ctatgaagcg agctgaccat 3247861 tacacgaggg aatagggaaa taaagatcat tcccacggtc agcgccagac cagcgcctgt 3247921 catcccaaat gtccagccgt cttttttctt acgaataaat acagccgcga gcataaagca 3247981 gatgacaatc aaaacagcga gcggaatggt aatctcgccg cggcgtgtaa acatgtctgt 3248041 ctgatacgca gaaagggccg cgaaggcaag aaccgctaca aaaacaacac ccattatctt 3248101 ttgcgccatt ttccgggcgc ggttttgcaa atcaccaatc gtacgcagcg tgataaacat 3248161 taatccatgc tggaagcaaa gaagcgttac cgtcacaccg ccaagtatag aatatacatt 3248221 gatataatca gatacatgtg cgtgaatgtt catgtcggca tcaatcggca tcccgcggaa 3248281 taatgtcgtg aacagcacac caagcacaaa cggaggaatt agactgccga aaaaaacgac 3248341 ccagtcccaa acctttaccc attttaaatg atccaccttg ccgcggaact caaacgcgac 3248401 cccgcggccc attaacgcaa gcagcactat gacaaacgga atgtaataac cgctcagcat 3248461 cgttgcatac cagtttggga atgccgcgaa aatggcgcct gcgccagtca aaagccacac 3248521 ttcattcgcg tcccagaacg gcccgatcgt gttgatcagc actctgcgtt ctaattcatt 3248581 atggccaaga aaacgggtcg ccatgccgac cccgaaatca aagccttcca aaaagaagaa 3248641 tcctacaaac aatacagcaa cgagtataaa ccaaagatca tgaagagatg ccatggtata 3248701 cctcctgact aaatggatct gttgatacag gcacatcatg atgattatca tgctccgcac 3248761 cttttttaat ctcacggata aacaagaaga caagcagtgc accaagaatc atgtacatca 3248821 caccgaatgc gatgattgag aataacaagg aacccgctgt tacgttaggc gacacagatt 3248881 gagcggttgt cattaacccc ataaccgtcc aaggctgacg tccgatttct gtcataatcc 3248941 agcccgcgga gtttgcaaga aacgggaagg aaatcaacgc gatcatgatg cgcaaatacc 3249001 atttgctgtt ttcaagcttt ttacggcggt ttaaccaaag gccgcctaac gcagcaagaa 3249061 tcatgacaac acctgctcct accatgatgc ggaagctcca gaatgtcgtt ttcactggcg 3249121 gaatgtagtc gccttttccg tatatttttt cgtactcagc ctgaagggtt ttcatccctt 3249181 tgacacttcc gctgaatttc tgataagcca agtagctcaa ggcataagga actttgattt 3249241 catttgagct tttttcattt tttgtatcga tcgtcgcaaa agcggtccaa gcagcagggt 3249301 caccgctgtc ttcccatagg ccttcactgg cagccatttt catcggctgt gattccatca 3249361 agtgctcagc ctgcatgtgt ccgctaaggc cgacgccaag accggcacaa agaccgacga 3249421 tcattgcgag tttaaaagat tgcttaaaga acggcacttc ttttttcttc agcagtttaa 3249481 aagcactcac tccggcaata aagaaagctc cagtggcaag cgcaccgaaa ataacgtgcg 3249541 ggaattcaac ccaaagctga gggtttgtaa tcaacgcgcc aaaatcattc atttccgcgc 3249601 ggccgttttt gatcgtaaag ccgaccggct cctgcataaa ggagtttgct gttaaaatcc 3249661 agaaagatga catgatcgtt ccgaatgata cgagccatat gcagagcgcg tgaattttct 3249721 tcggcaggcg gtcccagcca aaaatccata atccgataaa aatagattcc atgaaaaacg 3249781 ccaataatgc ttcaatcgca agcggagcgc caaatacatc tccgacaaaa cgggagtaat 3249841 ctgaccagtt cagtccaaac tggaattctt gcaaaatccc cgttacaaca ccgactgcga 3249901 aatttattaa gaataagtgt ccccaaaact ttgccatttt gagatacagc tcatttttct 3249961 ttacaagata aagagtctcc atcaacgcaa ccataaacac aagcccgata gacatcggca 3250021 caaacaagaa gtgaaacaac gttgttgatg caaattgtat gcgggctaat accaattcac 3250081 tcatgctttc tcctccattt ccggttaaaa ctgttaattt gctcactact tcacaaatag 3250141 aaccgagact ttgatcagta attcacaaaa tagacgaaaa aaatattgct caatatttca 3250201 caaatgtgtc aaaaagtcat ccaatatgat gcaagattgc cagactgacc aaatgacaca 3250261 atctctgact ggttcatatt aagtacttta caacgattca tttcaaaaat aaagcctaaa 3250321 atacctaaaa agtcccgcac tatgtgacgg atttttgtct attttgttgc ttatttatgt 3250381 cggctgctag gataaatgac cctttattat cgtacatcaa cacatcgttc cttgcgaaca 3250441 aaatgcttgc ccccgcccca gcactcgagt ctcagcattc cgtcttaaac cgattttagt 3250501 cagaatgcct cttttcattt gaaccggtaa gaggagaaaa gttgaatagt aaatttttaa 3250561 tatattaata atttcaattt tttagtatac ttaacatagt gaacaatttc actgcatcaa 3250621 gaatagggga ggtttttcaa tgggagagct tcaaacacac atgcaattgc aaacggatac 3250681 aattcacgaa ggggttcgaa aagagaattg gtttgcgaaa gccatgaata taaaagtagg 3250741 catcataccg cttcctgtgt atgccttgct gtttatatta atcactgttt ttgttatgca 3250801 tcacgatgta aaaagtgaca ttttgacatc cattgccgtc atggcgtttt tcgggtttac 3250861 ctttgcccaa atcggcaaat cgataccgat tgttcgttct atcggcggcc cggccatcct 3250921 agctactttt attccgtccg ctgtcgtgta ctatcacctg ctgcctaatg atatcgtcaa 3250981 atccaccaca gaatttacag aaaactcaaa ctttctatat ttgtttatcg ccggtattgt 3251041 cgtcggaagc attctcggca tgaaaagaga aacactcgta aaagcattca tgaaaatctt 3251101 tattccgctt attgtcggtt ctgtcacagc cgctattgtc ggactggctg tcgggacatt 3251161 gctcggactc ggatttcagc ataccctgct gtacattgtc attccgatca tggctggagg 3251221 agtcggagaa ggcgctatcc cgctgtccat cggatattct gacatcatgc ccatttctca 3251281 aggggaagcg tttgcacttg ttctgccatc gattatgctg ggcagcttgt gcgcgattat 3251341 tctagcggga ttgctgaacc gaatcggaaa gaaaaaaccg gaatggacag gcaacggcaa 3251401 agtggaccgc tccgaagaag agtcccctgc gctggaggaa tctcaaagcg gacagcaaat 3251461 gttcaacctt tctttatttg cgtcaggcgg tatccttgct gtttctttat acttagtcgg 3251521 catgctcgct cacgattttt tcggttttcc ggcacccgtt gccatgctgt tactggctgt 3251581 tctaatcaag ctgttcagat tggtgcctgc ctcaattgaa aatggcgcgt ttggagtgtc 3251641 ccgcttcttt tcaacagctg tgacctaccc gcttctcttt gcgattgggg tatccatgac 3251701 gccgtgggac aagcttgtcg ccgcttttaa cctcagcaat attatcacga ttctgtctgt 3251761 cgttgtgacc atgatggccg ttggcttctt cactggaaaa tggctgaaca tgtatccgat 3251821 tgaaaccgcc attattaatg catgccattc tgggcaaggc ggcacgggtg acgttgccat 3251881 tttaagcgcc gctgaaaggc ttgagctaat gcctttcgcc caggtgtcta cccgcatcgg 3251941 gggcgcgatt acagtatcct taaccttatt gctgctgcac cagttttatt gatccccgca 3252001 agcaagttct tcgtcaaacg aaagagcttg cttttttgca tgtccatgtt tttgcaagtt 3252061 cccatcccat gctatagtaa tagttggaaa tactagatag aaaggaatct ggcatgccta 3252121 tgggaactca tctatttctc tttatgcttc tcgggctggg attttatttg atatcagccc 3252181 tagctgcaaa actcattccg gccatagact tctggattga tattgttcta tgggtcggcg 3252241 ctgcggctta catcttctct catctctcat tcatggacgg cattgtctca ctcgcgacaa 3252301 tgttctactg ctattggacc gcaatggatc tcattgtttc agagcgtgtg gaaaaacctt 3252361 cgggagactg gcaggaaatc gagcttgcca aaaacaaaac acgcctcctg tcagacatta 3252421 cgctgaccgc cattgtgttt gcaggggctg tcattttttt catctatgga cctgacacaa 3252481 gccctctcaa atatgtgatc cttctcggaa tgatctccgg cggaggggca cttgtgaagc 3252541 gaatactgaa tgtttttagc gtaaaggttt tttattcagc agccttagaa aaattgcata 3252601 tcagctcaca ctatgaaacc cgtacatacc cgctttccga tttgaagaac attcagcttg 3252661 aatcaacagc agatctctta aagctccatc cgcttctgac gatgtattca tcccgtttag 3252721 atttgacaac aagctttcag caagtcatta aactgtctct tcccggcgaa acactgtttc 3252781 tgacggtgaa ggaaccgcaa aaatggaaaa caattcttca ggaatacaca gatgcagaaa 3252841 acaatgtgga caatgtgatt tctgttttgc cgttttatca tcgaaaaaat gtgaagcggc 3252901 tgctcggtaa gctttatttt gccgccagcg taaaaggggt atccgcttac gccttattgg 3252961 tgctcgcgtt atacgcatta cacgcctctc catgggtcat ggctgttgcc gtaatcctat 3253021 attgggtatt caacatgtat atgtcagacc gtgtgttgcg ggcggcgatg gacgccaagt 3253081 cttgtcatca tccgcatgta caggccgcgg ccgataagat tttcagatcg gccggcattt 3253141 cccatgtccg catatacgaa acggagagtg atgattacaa cggaatggca gtaggcatga 3253201 atgtcgggag gtcaatggtc atcctgacaa gcgccacact aacacttcca cagcgtgtca 3253261 ttgaaggcat tctggcccat gaggcgattc atatcaaaaa acgtgacgtt ctgtcatcac 3253321 agcttttgcg ttttctatat cttggagctg tcgtggggat tttcctcttg tttgagcagc 3253381 atatcaccca tcccgaggcc cacaaaattg cgctttgggc tttcattatg gcaatcatta 3253441 tcctattcca gctctatcaa tccttttgtt cacaatggat ggaggtgcgt gctgacaacc 3253501 ttggcgcatc attgctggac ggcggttaca aacaaatggc tgaagccttg agaatcttgg 3253561 cggttcggca agatgaggat atacagaaac aaagtgccta tagctctgaa gcaggtgaag 3253621 acgagcttca aattgattct ctcacccgtg ataaaagctg gtttttcaga ttgattgatt 3253681 ttcagttcgc tcctcatcct cctatgtatt ggcgtgtcgg cactttattg tcaaacaaag 3253741 gacatggggt gctaaagcgc tggctcagag accgactgaa agaatcgatc actttgaaat 3253801 gaaaccggtc agcgtttcat ccgtataaca gatatggtga aaaaagggag tgacgcgaag 3253861 tgattgtgat catcttattg tttatatcta ttattgtttt tctttcagtc attcagccgc 3253921 agccctcgaa aaacaaaagc cgccagcagg cggacagcgg gtatttcggt tattcagatc 3253981 atagctcaca ccatgatgga tgcagcagtg acggaggttt cagcgattcc ggctgtggcg 3254041 gcggaggggg cggcgattaa acgccgcctt tttttatttc attgattcga tgtacgcacc 3254101 aaaagccgag cctgacatgc ctggggacac gcgcacacga tggagggcat acattccctg 3254161 gtctctcgaa gccgcgcccg gttctgtcgt cacgcccatt tgatagcctg ttttttcagc 3254221 ggccttcagc gtctcctcat tgtagcgccc taccggatag ctgatgatgg tggtttgctg 3254281 atgaaacatg ttgtcgaaca gctttttcga atcagccatc tcactttgct gctgttgagg 3254341 cgttaatccg ttcagctcaa ggtggtcaat cgtatggctt tcaatcgata tgccgtgctg 3254401 tgccatttcc ttcatttgtt cctctgtcag atggtgctta tgtccgatcg atttgccgat 3254461 cataaaaatc gttgccttca tcccgtactt tttcagcacc ggatacgcat cttgataatt 3254521 gtcggtgtac ccgtcatcaa atgtgatcag cacgcacttc tcactcggtt ttttatcctg 3254581 cgtcagcatg agagatgcct ctttcggcgt taatgtctga tagccgttat catgaagcca 3254641 cttcatatgc gcctcgaatt ctttctttgg cacacggagg ctgtttcctg aagaaatgct 3254701 gtggtacatc aaaatcggca gctttgccgg tttctctgtt ttgatccatg cggatgtatc 3254761 gtcttctttt ttctgaactt gtactgcctt tttttccggt ttcttttgtt ccgcttttgg 3254821 catcggctgc tctgcattcg cctcttgatc agcacaagcc gcaagagcca aacagctgcc 3254881 caaaagaaag atgcttaaaa acaatcgttt catcgttctc ctgctttctg tctatttctt 3254941 cctccttttt catcggtttg attctgagat tttcaatagc aaaaaaccgg acatgtctcc 3255001 atgtccggtt tttttgatct tatcggattc tcacttctgt ctcactgtca aagaaatggc 3255061 ctttattcat atcaaatgca accgtcagct catcgcccga ttgaatatcg aggcgggcgt 3255121 cgatccgcgc aataaagtct tggttgtcta tctgcgaata aatcataatt tcagaaccga 3255181 gcagctctgc aacattaatt ttcgccttaa tcgaagagtt cttatatgat tccacgacaa 3255241 tcaattcatc atgtatatcc tcaggacgga tgccgaagat gacctctttg ccgatgtagc 3255301 ctttttcacg cagcactttc atttttcctt ccgggacggt taatgccgca gaaccgattt 3255361 tgattaagcc atccgtgagc tttcctttga aaaaattcat cgccggtgat ccgataaacc 3255421 cgccgacaaa gacgttttca gggaattcat atacatcctt cggcgtcccg atctgctgaa 3255481 ttttcccatc tttcatgact acaatccgtg tcgccattgt cagcgcttct gtctggtcat 3255541 gcgtcacata aatcgttgta gtctgcaatc tctggtggag cttaatgatt tccgcccgca 3255601 tttgcaccct cagcttcgcg tccaggtttg acaaaggctc atccatcagg aacacctttg 3255661 catcccgcac gattgcccgg cccagcgcaa cccgctgtct ctgtccgcct gacagcgctt 3255721 tcggtttacg gtgcaaatat tcctcaagcc cgagaatttt agcggcttct tcgactcttt 3255781 ttttgatttc aggcttcggc attttccgaa gcttgagccc gaacgcgata ttatcgtaga 3255841 ccgtcatatg cggataaagc gcgtagttct gaaataccat cgcgatatcc ctgtcctttg 3255901 gcgctacatc attgacccgt tttccttcaa tataaaaatc acctttcgaa atttcttcaa 3255961 gtcctgcgac cattcgcagc gtcgttgatt tcccgcagcc ggacgggccg acgaatacga 3256021 taaattcctt atcggcaata tgaaggttaa agtcatcaac cgccggttcc ttctgatcat 3256081 aaaatttata aatgtgctcc atccgcaatt cagccatcta acatccccct ttgttattgt 3256141 aaacgctttc ttatattgag tgtaacagca attccctctc gctaaaatgg gcagcgttca 3256201 taaaatcacc cagccatttt tcgtgcatat ttccaattta ttctgaactt tcattttgca 3256261 ggcagataaa ataggcaaga agcgcgcctt tgtacgattt gatatctatc cctgaccgct 3256321 caataaattt atcaatccga tattgcaggc tgttgcgatg cagatgcagc tttttcgctg 3256381 ttaatgtgac gtttgagttg ttttcaataa acagcttaat ggtcttcctt agctcagatt 3256441 cacttccaaa taaaagctca gcttcttcag agagcagtgt ttccagtttt tctttttctg 3256501 tttctaataa tagaaaagga aagatcatct caaaggtcac actctgcacc tgaggcagcc 3256561 gtttttcagc aaacaggaaa tacgcctgtt cacgagcgta atgttttcgc agacactcat 3256621 ccggctcgta aaatcttccg gcgtaaaaac ggacactgaa gtagaaatca ctttcaagaa 3256681 ccttagcgag cgattccagt tcgtccttct ccgccgccgc ttcactttcc tgctcgacaa 3256741 tcacacctct gtcctcatgg atccacacaa tcacaaaaga caccggccaa aaatggcgaa 3256801 ccgcttccgt aaaggacgtc ctttctattt tgccgaataa atgaaagtga acaaatctcg 3256861 tccgtttctt tatatacgcc ggcaattccc ctctggaaaa aaggaacgaa aaccacttgt 3256921 tttcctcagg tgatttcata gacagttgat tgccctcatc cgcaggcgtc aaaaatgact 3256981 gcagcaccaa tacttctttt tcactgatct ctgttttcgg aatggagata tatctctgat 3257041 tgctctcatc aaaaaaacat agacagcctt cccttatgca aagctcctca gacacaatcg 3257101 aaccgggata aatagccagc agcgatttca tagagtctcc tctcttatgt aaggatctgt 3257161 atattcagta taaggcgaaa cacacatgtt ctccactaaa aaagagtata tccggtatag 3257221 atagacgaga aactgaaagg gaaacctcat tcgtttacat attggcttca gcggaaatag 3257281 aagaagacat gcaggaccaa aggagggtca tcttatgagt ttcgaaacgt taaacaaaag 3257341 ttttatcaac ggaaaatgga ctgggggaga aagcggacgt acggaggaca ttttgaatcc 3257401 gtatgaccag tctgtgatca caacagcatc tttggcaacg ggcaaacagc ttgaggatgc 3257461 gtttgacatt gcacagaaag cccaaaaaga gtgggccaag agcacgacgg aagaccgaaa 3257521 agccgtgctg caaaaagcgc gcggctattt acacgaaaac cgtgatgaca tcattatgat 3257581 gatcgcccgc gaaactggcg gaacgatcat taaatcaaca atcgagctgg aacaaacgat 3257641 tgcgatttta gatgaagcca tgacgtatac tggtgaatta ggcggcgtca aagaggtgcc 3257701 atccgacatt gaagggaaaa ccaataagat ttaccgcctt ccgctaggtg tcatttcatc 3257761 gatttctcca tttaatttcc caatgaatct atccatgaga tccattgcgc ccgcaattgc 3257821 gctgggtaac agcgttgttc acaagcctga tatccaaact gctatttccg gcgggaccat 3257881 cattgcgaaa gcgtttgaac acgccggtct tcctgccggt gtccttaacg tcatgctgac 3257941 ggatgtaaag gaaatcgggg acggcatgct caccaatcca atcccgagat taatcagctt 3258001 tacagggtca acagcagtcg ggcgccacat cggtgaaatc gccggtcgcg ccttcaaacg 3258061 aatggcactt gagctcggcg gcaacaatcc atttgccgtt ctttcagatg cggatgtcga 3258121 tcgtgctgtg gatgccgcga ttttcggaaa atttattcac cagggacaaa tctgtatgat 3258181 tatcaacagg atcatcgttc atcaagatgt atacgatgag tttgtagaaa aattcaccgc 3258241 ccgtgtcaaa cagcttccgt acggcgatca aaccgatccg aaaaccgttg tcggcccgct 3258301 gatcaacgag cgccaaatcg agaaagcgct ggagatcatt gagcaggcaa agacagacgg 3258361 cattgagctt gcggttgaag gaaaacgcgt cggaaacgtg ctgacgccgt acgtctttgt 3258421 cggtgcggac aacaacagca aaattgccca aacggagctg tttgccccaa tcgcaaccat 3258481 tattaaagct ggcagcgacc aggaagcgat tgacatggca aatgatactg aatacggcct 3258541 cagctctgcg gttttcactt ctgatttaga aaaaggcgaa aagttcgccc tgcaaattga 3258601 cagcggcatg acccatgtca acgaccagtc cgtcaatgat tcgccgaata ttgcctttgg 3258661 cggaaacaaa gcaagcggtg tcggccgttt cggcaatccg tgggtcgtcg aggaatttac 3258721 cgtgacgaaa tggatttcga tacagaagca ataccgcaaa tatccgttct aaatgaaaaa 3258781 atccctctgt ttcaagtaca gagggatttt tctttattta gatatatcca caaacccttc 3258841 gccaaacaca tcgcgtacgt catgtacgat cacaaacgct tttttgtcgc agcttctaat 3258901 gatttttttc agcatagaca gctcctgttt gttaatgacg atatacaaaa tctcttttga 3258961 ctggcccgta taatttccct tccctgataa aatcgtcacg ccccgatcca tcaaggtatt 3259021 tacctgctct gcaatctcac tcttattttc tgaaatgacc gtaatggctt ttttcgtatt 3259081 caaaccttca ataatgaagt ccatcacttt ggtaccgata tacagcatca cgatcgtaaa 3259141 catcattttt tctgcaccaa taataaaata agagctaaat actacgatta aatcaaaaaa 3259201 caagagtgca tagctgatat tccagtctaa atatttatta gcaattctgg ccagaatcgc 3259261 ggaaccggcc gtcgtcccgc cgacccggat aatcatgccg atcccgactc cggcaaatac 3259321 acctgcgaaa atcgtattaa tgatcaattc atcagacgga atgctccacc catgtgtcag 3259381 atgaagaaaa agcgaatttg ccgcaaccgc aatgatcgta taaaccgttg tttttccatc 3259441 aagaaacttg tagccgatta aaagcaaaaa cgcatttaag ataaagttcg tgacaccagg 3259501 agaccattga aacagataat acaaaatcag cgtaatccca gtgactccgc cttccccaag 3259561 atcattggga atcgcaaata aattaaccgc aagcgcgaag aaaaaagcgc caatcacaag 3259621 cataagtaca tccagcattc tctttttcat cacgaaaaca ctccttttca ttgttctgtt 3259681 ctagcaaata aaaaaaccca ggagaacgct ctcgaaaaag agcagaaact cctgggcttt 3259741 tatcccaccg tgtcataaca gccaagctgc tatgtgtttt ctctcggtca cagtccaatt 3259801 tgcattgcgg aaccctagaa aaccactgtt tttatcatat ccttttcact ttccaatatt 3259861 agcattataa gggacggttc gaattggttc aaggggtatt tgcggagttt tcatcagata 3259921 agctggaaaa aaatacgatt tatctattaa aaaagaacag atataaccga taagaaaaaa 3259981 agcatatatt ttacaagcga atgtaactat aaatgataat aattataaga aattcataat 3260041 tttatattga ctaagagaaa taatataggc attatagtac atatgtttcg tacattttat 3260101 tacataggag gaaatataat ggcaggaaaa ctagtaccct gtaaagcttg cggtcaagaa 3260161 attgcaaagg gtgtaaaaaa atgtcctaac tgcggtaagg atcaacgtaa cttttttatg 3260221 cgacataaaa tcattacgtt tattctcgca gttgttgtca tcattattat cggtaatatg 3260281 attggcggcg gaggcggctc agaagccact tccaaaacat caagcagcag caaagcagaa 3260341 actgaaaaaa catacaatat cggtgatacc gtaaaaactg aaaaaactga agtgacggtt 3260401 acgaaggtag aggacagaga tactgtcggt actcaatatg ttgaaaagaa agcatctgag 3260461 ggaggtacaa ttgtagctgt tcaatataca attaaaaacg tatctaaaaa gccgattagc 3260521 tctttttcaa ttccaactgt taaattagtt gatgctgatg gtacttctta tgattctgat 3260581 attgatgctt ctgtaaacta tgcaactgag acaaaagttg ataactctaa aattttgagt 3260641 gatctaaatc ctaatattaa agtaacaggt gtaaaagcat ttgaagttga caaggaagct 3260701 tatgcaaaag gcacttggaa actaaaattc agtaatgatg ttattgtgaa aatcaaataa 3260761 cagctaacaa gggtgcctgt ttaggcaccc ttgttcttta aaaaaggcct tctcaattga 3260821 gaaggcctcc attcttattc cgcactctta tacccattca cattagaaga ctgccatctc 3260881 caggaatcag cacacatttc ctcaaggccg cgtttcgctt cccagcctag ttctcgcttg 3260941 gctttcgcag gatctgcaaa gcatgtggcg atgtctcccg gacggcggtc cgcaaaacgg 3261001 tatggaacct ctttccctga cactttttca aaggctttga ccatttccag cacgctgtag 3261061 cctgtgcctg ttccaaggtt gtatgcatcg gctcctgtag agttcaatac tttttccagc 3261121 gccttgacgt ggccttctgc gagatcaacg acgtgaatat aatcgcgtac gcctgtcccg 3261181 tcttttgtcg gatagtcatt tccgaatacg cttaattgct cgagcttccc gactgctacc 3261241 tgtgccacat acggcataag gttatttggg attccgttcg ggtcttcacc gatccgtccg 3261301 cttggatgcg cgccgaacgg gttaaagtaa cgaagcagcg caacgctcca ctcattgtcg 3261361 gctgtatgca aatcacgcaa tatttgttca agcatgagct tcgtctgccc ataaggattt 3261421 gtcgcgccta atggaaagtc ttccgtaatc ggcgatgttt ccggaacgcc gtatactgtc 3261481 gcagatgaac tgaatacgat tttcttgacg ccgtatttct ccatggcctc gcataaaata 3261541 aacgttcctg tcaaattgtt atgataatat ttgaggggaa tcgccacaga ttcgccgact 3261601 gcttttaacc ctgcaaaatg aatcacagct tcgatttcat tttcagcaaa aacggaatct 3261661 accgcttccc ggtccaataa atccgcttcg tagaacgtta aatcttttcc tgtaatctcc 3261721 ttgacacggt tcagcgcttc agctgaactg ttggacagat tatcaagaac aacaatctcg 3261781 tagccgctgt tcaatagttc aacacatgtg tggctgccaa tgtaaccggc accgccagta 3261841 acaagtattg ccatgatgta aaccctccta aaaaatgacc tgttttcatt atatagtgtt 3261901 tagaaccggt ccacatccat ttttaagaag tttaatcgtt tattaatagt tttttcatat 3261961 tttttagctt aaacccttgc cagcaattcg atagaggttt cagcaagaat gtgctctttc 3262021 atttcttgat agagctcatt caagtaaaag cccggctgaa gattcagctc agcatctaaa 3262081 gcatagaccg tcaatgtata cgcatgatcc ttgtcaggcg gtgtcggccc gcaatactgg 3262141 tgaatcacct ttggatcgtt gcttcccgca agcggtgaag caaagctgtt ttgcccttgt 3262201 atcatcaagt cctgtctttc ctcactcgca tgttcaggaa gctctccgat gtaagccgga 3262261 atattagccg ctgtccagtg aatccagctg aatccgcata cgggaatggc gtcatgatcg 3262321 atgaaagtaa gtgcgagcgt ctttgctccg gacgggatgt catcaaaatg aattggaaag 3262381 gatacaaatg ggtttccttc tctcttatat ttttcatccg cgtattttga atacttgtca 3262441 tgtaaatatg gatttgcttc tacgtatatg ttcatatgaa tccctctctc tattttctcg 3262501 ttctataggt atactaaacg aatcgatgta taatcagtga taaacaaata cgcatgtaaa 3262561 cgtaacaatt tgttatggat aacttgcagt gaaggagata tttcatggat ttaaaatggc 3262621 tgcaaacctt tattgccgca gcggaatcag agagcttcag ggaggcggct gagcatctgt 3262681 atctcacaca gcctgccgtt tctcagcata tgaggaaatt ggaagatgaa ctggacatga 3262741 ggttgttttt gcatagcgga agacgagtcg tactgactga cgaaggcagg ctctttttgc 3262801 cttatgccaa agaaatgatc catgtttacc aagctggaaa gcagaaagtc agtcaatgga 3262861 aacaggggta cagccgatca ctcacgctgg ccgtacaccc ctacattgcg tcctatatct 3262921 tgcctcgctt tctgccagcc tatatccaaa aacatccgca tgtcgagctt tcaactcatg 3262981 tggctggatc tgacgctatt aaacaagcgg tggaacacaa tgaagctgat attggtttgt 3263041 cgcggaaaga cccgaacacc aacactcttt attatcagca tatatgcgaa ggtacgcttt 3263101 gtctggcggc tcctttccaa gaaagcagac cggatgctgc atccgtctta acccgctatc 3263161 ggctgctaac gcatgatcat ccgtcatatg gggatgcctt tttagataac atccgatcac 3263221 attacccgta tcttcaaatg atggctgtcg ggcagacgga tacggctgtc cacatgatga 3263281 aagcgggaat gggggcatct ttcctcccta cctacattat caaacaggaa gaagccgaaa 3263341 aaaagctgat ggctgtcagc acgcctgcac atctagaatt gcctgcgtcc caaacgttta 3263401 tgatgtggaa aagaaacagc gaagacattc agcattttca cgccatgtta catgacttta 3263461 tgcagcgcga acaagtatag agctgaaaaa tcaatctgcc ggttgacgtt tttctttcct 3263521 attttcgcta tgcttaatgc agaaaggatt tgatgacatg gcgatgagcc cttatatttt 3263581 tattgtattg attcttatta ttttatcgat gtatcgagaa agaacggtaa agcccgggaa 3263641 gttgctgatc attccactgt tgctcttatg gggcgtatct gcatcgtttc agccggcgta 3263701 ttttcattcc gtattacatg tggcgatcag cggcatttta ttactgatcg ggctggcctg 3263761 cgggtttggc attgggaaga tggtaaatgt acggattcac ccggaaaccg gaaaggtcac 3263821 ttcacgcggc tcacttggga gtgttatcct cattctagtg atactttctt tgcgcatggc 3263881 cgcgagaaca tggctgcctg agagcaacga gatgtttatt gccattattc attctatgtt 3263941 cttcgttccc ctcggcacca tcacagcccg caacatcatg ctttacaaag catacagacg 3264001 actgaccgct ggcaaagtat ccattcaata accgaaagaa ggaccagcat gaacggacaa 3264061 actccggctc ggcactacta caagaagctt gtgccgagcc ttattctcat tttgaattgc 3264121 atacaatttt tatctcatcc aactaaggct gatcccattt tgttagcatt tgtatttgcg 3264181 gtatacttag cattcatttg gatcattccc tatgtggcat ccactgctgt tagtttgagc 3264241 atattcatcg gactctggct cctgaccgat ttcttttggg ctgtttccgg ccaagagcag 3264301 ggtgccgcct attttttgat tgtattttta atgatatatg ccgcctttag actcccttca 3264361 cggctatcct tgatcttcac agcatgttta attggaggca acatattact cctatcctca 3264421 caagggggaa gcttgaatac catcatcagc aacatctcga tcatgctcgg tctgtacgtc 3264481 ctcttctcct ccatgcgttt cagacgagaa gcgagaaggg aggctgaacg gaatcatgct 3264541 gaattggcaa aaatgcatgt gcagctggag catgctcata aagaactcca gaaagcgcat 3264601 gcagagctgc aggaggcttc tgttctttca ttaaggtacg cggtccttga ggaacgtaca 3264661 agaattgccc gcgacattca tgacagcatc ggtcacgagc tgacttctgt gattgttcag 3264721 cttcaatccc ttccctatat ccttaaaagc agcaaggagg attcagaaaa agtcattcaa 3264781 aatgtactga gtgtcgccag ggagtgtctt caagaagtgc ggtctgttgt tcaccaaatg 3264841 ggccgtagtg aatcgatggt ggggcttacc gctttgcggg ggctcattca tcaagtggag 3264901 gaacggagcg gcttgcacgt ttctttagat actgccggac tgtcagaaga gtcttggcct 3264961 ccaaacgtga gcgaaacgat ctaccgcatc ttgcaggaag cgctgaccaa tatcattcgt 3265021 cacgctgacg cttctcatgc ggcggccgtc atttctaatg acaagtccca tctctatgtc 3265081 acaatcaccg acgacggaca attcaccggc agccttactt atggatttgg cctgacagga 3265141 atgaaagagc gcgcagaaaa agcaggcggt tcccttactt tcagtgccgt acagccgagc 3265201 ggcctgaaaa ttgagctgtc attgccgctc atgacaacga ataaggagca aaaagatgaa 3265261 caaagataaa atacgcgtag cgcttgccga tgatcagccg cttgtgcgtg aaggcttccg 3265321 ctacgtcatc aacgcacaga cggatatgac ggtttctggc gaggccggcg acggtcacga 3265381 tattatagca ctcgcaaaac aaacaaaacc cgatgtcatc ctcatggatg tccagatgcc 3265441 gcgttgctca ggcatcgaag cggcgaaaga cattatgtcc gcacttccaa atacaaagat 3265501 agtcatttta accacctttg acacggaaga atacgtattt gaaggcatcc gtgcgggcgc 3265561 agtcggctat ctgctgaagg atacacttcc tgaggagttg atagatgcga ttcgcgctgc 3265621 ggccagaggc gaggcgattt tccgtacagt cacagctgct aaaatcatca gtgagacatt 3265681 tcgggcgaaa cagcaaactc atgccgaaga actggcagag ccgttcacca aaagagagct 3265741 tgaggttctt cagcaaatgg cctacggact gagaaatgag gatattgctg aaaagctttt 3265801 cgtcagtgaa agcactgtga aaacccacgt gcaccgcatc ctgcaaaaat gcaatgccca 3265861 agaccggaca caggcagtcg tttttgccat tcgaaacggt attgtgcaat agaaatctct 3265921 catcccgcca tgctaaaata agacaaagga gatgattgga aatgaaagaa gaaatcattg 3265981 aacggtttac tacatatgta aaagtcgata cacagtccga tgaatccgtt gacacttgtc 3266041 cttccacacc cggccaattg acattaggaa acatgctagt tgatgaattg aagtccatcg 3266101 gcatgcagga tgcagccatt gatgaaaacg gctatgtcat ggcaactctt ccctccaata 3266161 ctgaaaaaga cgtgccgaca atcggctttc tcgctcacgt cgacaccgct acagacttta 3266221 ccggcaaaaa tgtgaatccg caaatcatcg aaagctatga tggaaaagac atcgttctta 3266281 acgaacagct gcaggtcacc ctgtcacctg atcaattccc tgagctgtcc ggctataagg 3266341 gccatacact catcaccaca gacggcacca cccttctcgg cgcagacaat aaggccggta 3266401 tcgctgaaat catgacagcc atggattacc tcatcaaaca ccctgaaatc aagcacggca 3266461 caatcagagt cgcctttacg cctgatgaag aaatcggaag agggccgcac aaatttgatg 3266521 tgaaacggtt caatgcatcc tttgcctaca cggttgacgg cgggccgctc ggcgagcttg 3266581 aatatgaaag cttcaatgcc gctgccgcaa aaattacgat taaaggcaac aacgtacatc 3266641 ccggaacagc taaaggaaaa atgatcaact ctgcgaaaat cgcgatgaag ctgaacagcc 3266701 tgctgccggc agacgaagcg cctgaatata cggaaggtta tgaaggcttc taccacctgc 3266761 tgtcgattca aggagacgta gaggaaacaa agctccacta cattatcaga gactttgaca 3266821 aagagaattt ccaaaacaga aaagaaacaa tgaagcgtgc cgttgaagaa cttcaaaacg 3266881 aatacgggca agaccggatt ctgctggata tgaacgacca atactacaac atgagagaga 3266941 aaattgaacc tgtcatcgaa atcgtcaaca ttgccaagca agcgatggaa aacctcggca 3267001 tcgaaccgaa gatttccccc atccgcggcg gaaccgacgg atcacagctg tcctacatgg 3267061 ggcttccgac gccaaacatc tttacaggcg gggaaaactt ccacggcaaa tttgaataca 3267121 tctcagttga caacatggtc aaagccgtaa atgtcatcgt tgagattgca aagcagtttg 3267181 aagcgcaagc ataacgccaa aagccagtcc aaaaaaggac tggctttttt gtgtgaaaat 3267241 gaaacatttt aaacacgtcc tccgtaaaac aagtatcaac aaatgaggag gaaaaacaat 3267301 gacaaaacat gcaatcgctg ccaagagtct cttgaaaaaa tggatcattt ccaggccgct 3267361 taacatgaaa aagaaatcca gcccatttca aaaaatcaga aaaatgttca aacgcttctt 3267421 caaataaaac atcaaatccc ctaaatacaa tccgtattca cccgtaccgc ccaaatgctc 3267481 cgtaatttgg gttttttgtg ttcaattccg caaaataggg tataaaccaa acaagcaaga 3267541 aaacagcacc caaaaacagg taattcgaat tacgtaaact taggttaaaa gttatataaa 3267601 ggaatttatt ttatcgtcga tagtaactat agaaccaatc atcaacaaga gcaaacagcg 3267661 taattcaaga ctattttcag gtcatcaggt aatactgttt tagagggaca gtttcttgtt 3267721 atttattgat ttagaatttt ttgaatactt tttggcattt tatccgtaca atagagagta 3267781 ccaaaacttt ttttgggagg tatgtaatat gatcctattt attatcatcg cattatgcgg 3267841 ctatcttctt ttttctttca gcaaggacaa tcgccgcaaa ccgcaaaaga caagccctct 3267901 gccagcagcc gcacctcatc acaacaacct aatcgacctt gacgccatcc gccaaaaacg 3267961 ccggatgcat ctttcctaat tctatatttc aaacgaaaag gctgctgaat cacgcagcct 3268021 tttaaaattg ttttgattta gagcctgaaa ccttttcgcc acctatccgt aatttcatac 3268081 aaggcaaacc caaaggagac ttcagcaatg atcgagttat ttatgaaaca aaaaatgttc 3268141 tcatttaaag atgcatttca catttatgac cgggatgaac aagaaacatt caaggtggag 3268201 gggcgttttt tctcgttagg agactcatta caaatgacag actcatctgg gaaaacgctc 3268261 gtttccatag aacaaaaact aatgtcttta ttgccgcgct atgagatttc aattggcggg 3268321 aaaacagttt gtgaggtaac gaagaaagta acgttttcca aaccgaaatt tgtgatttcc 3268381 gggcttaact gggaaataga tggtgattta tggagggatg aattccaact gacggacggg 3268441 gaaaatgtcc ggatgtcagt gagcaaaaag tggctcagtt ggggtgattc ctatcacttg 3268501 cagattgcat acgaggaaga tgttctgatt tgcactgcca tcgctatcgt gcttgatatg 3268561 gttttatata acgatgaaga tgaaagtatt ttctaaaaag cattgacaat tgatccaaaa 3268621 gtaataatat taagataatt gaaatctgaa tatgaagttg taccttatca agagaggtgg 3268681 agggactggc cctatgatac ccggcaaccg ctgtttcaaa cagaatggtg ctaaatcctt 3268741 aagaacattg cgttcttgca gatgaggcgg agatttgatc gttcaagctc ttccttacac 3268801 aaaggaagag ctttttacat gcttaatatt tcagaaaaga ggcgaataac atggctcaac 3268861 aaacgaatgt tgcaggacaa aaaacagaaa aacaacgcaa agcacctttc cgcgccgatc 3268921 atgtcggcag cttgcttcgt tccgttccgg taaaggaagc ccggcaaaaa aaagcggctg 3268981 gtgagatgac agcggaacag cttcgtgata tcgaaaatca agagatcacc cgcatcgtgg 3269041 aaaaacaaaa agaaatcggt ctcgatgtgg taacagacgg ggaattccgg cgttcctggt 3269101 ggcattatga cttcctggaa gggcttgacg gtgtggaacc gttcatcccg gctgagggga 3269161 ttcagttcca taacacaaaa acgaaagcgc gcagcatcaa agtgacggga aaactcgatt 3269221 ttacgagcca cccagcgctc ggtgattatc aatttttaca tgagattgcc ggtaacgcga 3269281 cgccaaaatt gaccattccc agtccaaata tgctgttttt tggcgaaaag gcggataaag 3269341 ggatttatga cgatcaagag gaatactttc atgatatggc ccaagcgtac aaaaaagcaa 3269401 tcaaagcctt ctatgatgct ggctgccgtt atctccagct tgatgatacg tcatggtctc 3269461 tcttctttga ggacaaaggc agagaggttg tccgggcgct cggcggtgat ccagaaacat 3269521 tgccagccat atttgccaaa acaattaacg atgccgtcgc agaccggcct gacgatttaa 3269581 cgatcacaat gcacatttgc cgcggcaact tccgctcaac ctgggcggca tcaggagggt 3269641 acgacgctgt agcggaaacg attttggacg gcttaaacct tgacggcctt ttcttggaat 3269701 acgatgatga ccgctccgga aactttgatc cgctccgttt tgtgaagcgc aaggatctgc 3269761 aaattgtgct cggcttgatc acatcgaaat acggcgagct tgaaaatcct gaggatgtga 3269821 aacgccgtat caatgaagcc gcgcgttttg tcagcttgga ccagctatgc ctgagcccgc 3269881 agtgcggttt cgcctctaca gaagaaggca accttctgac agaggagcag caatgggcaa 3269941 agctgcgcca tgtcatcgac attgccaacg atgtgtggag ataatctatc attgacagaa 3270001 atagaaaatg tgtgaataat agatactatc agaaaattta ataaaaaggt tttccttatc 3270061 aagagaggtg gagggactgg ccctgcgata cccggcaacc gctgtttaac agaatggtgc 3270121 taaatccttt agagcaatga ttgctcttga agataaggtt gagattgtca cgcaagctct 3270181 tccttatcca aaggaagagc ttttttatat ttgaatggaa agaaggaatg gacaacatgt 3270241 cacaacaaac aacacccgca gaacaaaaat cacttcaaag aaaaaaaccg ccgtttcgcg 3270301 cggatcaagt cggaagcctg ctaagatctg agcccgtcaa aaaagcgcgg ctgcaaaaag 3270361 cggccggcga aatgaccgct gagcagcttc gccaaattga aaacgacgaa atcatccgca 3270421 ttgtggaaaa acagaaggaa accggcctga acgtcgtgac agacggtgaa ttccgcagag 3270481 catggtggca ctttgatttc ctggaaaact tagatggcgt tgagccgttt actcctgagc 3270541 aaggcattca attccataac gtacagacaa aagcacgcgg cattaaagtc acaggcgata 3270601 tcgacttttc aactcaccca atgcttgaag attactcatt tctccatagc attgccggtg 3270661 acgcgacgcc aaagatgacg attccaagtc cgaatatgct gtttttccgc ggaaaactgg 3270721 aaaaggatga atacaaaaac gattatcaac ttttccagca cgatgtatcc aaagcatata 3270781 aaaaagcgat tcaagcgttt tatgacagag gctgccgcta cctccagctt gatgatacag 3270841 cgtgggccgt tttcttatca gaaaaaggct taaaacaaat cgaagcgttc ggaacaacgc 3270901 ctgacgagct tcgccagctg tttgcgaaat ccattaacga cgcgattgca gaccgcccgg 3270961 atgacttgac ggtaaccatg catatttgcc gcggcaactt ccagtccact tggacagcgg 3271021 aaggcggcta tgacgcagca gccgaaacca tttttgacgg cttgaatctt gacggacttt 3271081 tcttagagta tgatgattca cgctcaggcg gatttgagcc gctccgttac gtaaaacggt 3271141 ctgatcttca gcttgttctt ggcttagtga catctaaatt cggtgagctt gaaaatccgg 3271201 atgacgtgaa acgccgtatc gaagaagcgt cccgttatgt aagcttagac cagctttgcc 3271261 tcagccctca atgcggattc gcttcaactg aggaaggcaa caagctgact gaagaacagc 3271321 aatgggcgaa gctccgccat gtggttgaga tcgctaatga tgtttggaaa taagcaaaga 3271381 aaaaaacaca cttgattccc tagcggagca agtgtgtttt ttatgtcatt gtgcggtgta 3271441 gcccccatca aggacgacag cctgcccagt gacgcccttc gccttctcgc ttgccaaaaa 3271501 cacggcataa tccgcaattt ccttgacgga aagcagtcgc ttttgcggca caagcggaaa 3271561 aatgacttgt tcaagtacag agtcgtaagg gacatttcta gttttcgata gatcgctaag 3271621 ctgattgcgt acaagctggg tatcgacata acccggacag agcgcattga ctgttatgcc 3271681 gtggggcgcg ccttccagcg cccctacttt tgtgagtcca atgacgccgt gcttggcgct 3271741 attataagcg gatttccctg caaagcccac taatccatta acagacgcaa tattaatgat 3271801 tctgccaaac tgctgttttt tcatgatcgg aaaaacatgc ttcattgcaa taaagggagc 3271861 cgtcagcatg accttgatca gctgttcaaa ggtgtctgtc ggaaactctt caatcggagc 3271921 gacgtgctga ataccggcat tgttcaccag aatatccaag cggccgtatt gtttttggat 3271981 gacgttcacc gtatcagcaa cttgcgcttc ctttgtcaca tcatacggaa tggccgccgc 3272041 gtcaaagcct tcttctgcaa gcttggaggc tgctttttca catgcttccg gacggaggtc 3272101 tgaaacgatg acgctggcac cttcccgggc gaattctctt gcgatttcga atccgattcc 3272161 gccggcagcc cctgtcacca aagcgacttg ttttctcatg tcaaacacct tcccattaag 3272221 aattgagtac agactggctt acagcgaaat cagcttctgt tttttcataa acctcttcaa 3272281 ttgtgacacc atcctgaagc tccgtcagtg tcatgcggcc gttcacaaaa tcaaatacag 3272341 ccaaatccgt aatcagcctg tgtacgactt tctggcctgt cagcggaagg gagcatgttt 3272401 ttttcacctt tgattcacca tgcttattga cgtgctccat gatgacaacg attcgtttcg 3272461 ccccgttgac gagatccatg gcgccgccca tcccttttac cattttgccc gggatcatcc 3272521 aattggccaa atccccctgc tccgaaacct ccattccgcc gagaatagct aaatcgatat 3272581 gcccgcctct tatcatcgcg aatgactcag cgctgtcaaa ataagaggcg cctgtcactt 3272641 cagtgatcgt ttcctttccc gcattgatca aatccgcgtc ttccgttcct tccagaggat 3272701 aggggccaat tccgagcaag ccgttttccg actgaagcat gacgtgaacg ccatcgggta 3272761 tctcatttgc gacaagcgtc ggcattccaa tcccgagatt cacattcatg ccgtccttga 3272821 tttcttgtac agcccgtttg accattcgtt ttctcgcttc cttcacttgg cctcaccctt 3272881 tcccgatgct tgctgaactg ttcgtttttc aatccgtttt tcttggctcg cgccaagcac 3272941 gacatgctgt acgtaaattc ccggcgtatg gatgtgatct ggatcgagct ctcctgcttc 3273001 cacgatttct tccgcctcgg caatcgtgat cttgcctgcc atggcggcaa tgggattgaa 3273061 atttctcgcc gttttcctaa aaatcaaatt gcccatggtg tccgctttcc acgctttgac 3273121 gatcgccaca tcgccggtaa tgcctcgctc cagcacataa gtccggccgc cgaatgtttt 3273181 atgttctttt ccctcggcta tggaggtgcc gacgcctgtc gccgtataaa atcccggtat 3273241 gcctgcaccg cctgcacgaa ttctctcagc gagcgttcct tggggaacaa gctctacctc 3273301 aagctctccg cttaaaaact gccgctcaaa aattttattt tcaccgacat aggaagcgat 3273361 cattttcttg atttgcttgt tagccagaag caaaccaagc ccccagtcat cgactccgca 3273421 gttattgctg acaacggtta aatcctttac tccctgatct cttatagaca aaatgagctg 3273481 ttcagggatg ccgcacagcc caaaccctcc cgcgatcagc gtatccccat catgaatcag 3273541 tttcgcagct tccttgcttg atgacagcac ttttcccata ttgatgcccc tttcgttttc 3273601 ttctacacta gaccagtcag gctgtaaatc gcgatcacag caaatacggc agccgtttta 3273661 atgagcgtga tcgcaaaaat atcgcgatag gattgccggt gggtcaaacc cgtcacggcc 3273721 agaagcgtga taacggcgcc attatgcggc agtgtatcca tcccgcctga tgccattgaa 3273781 atgacccgat gcatcacctc tggcggaata ttgtaagcct gaatcgcctg taagtattgt 3273841 tctgacatcg cgcttaacgc aatgcccatt cctcccgaag ccgagccggt gattcccgcc 3273901 agcgcagttg tcgtaacggc gccatttaca agcggatcgg taaaagtatg tgaaattccg 3273961 ctgctcagct tatgaaaccc cggcagcgcg gcgataatgc cgccgaaccc gtactcagca 3274021 cccgtattca tagatgccag caaggcgccg ccaattcctt cattcagccc ttccttcaat 3274081 tgggcaaaca cacttctcca atcaaataat atcgttgtga tgatgccaat cactaaagca 3274141 atctccaccg accaaatagc agccgctgaa gaaatatcaa gcctgccgaa ctcctttaat 3274201 cctatggaag aaaaatcaaa tccattcgga taccactttg gcaggtaaat ggtgaaatat 3274261 ttattcactg caccgacgag aataagcggg acaaaggcaa gcgcgtgccg aatcgggctt 3274321 ttgtccggtt cagccgcgga ctcaatcgat tcaggagcag gagcattctg cgaatcaaaa 3274381 ccgccatagc cttcgccaga tgcctgcgct ttcttccgcc ttgattccaa atagagcatc 3274441 ccagctgcca gcacaatcac tgcgcccatc aaacccagcc aaggggcggc ataaatgtct 3274501 gttttgaaaa acgacgtcgg gatgacattt tggatttgcg gcgttcccgg aagtgcgtcc 3274561 atcgtaaacg taaaagctcc taaagcaatc gtacccggga tgaggcgttt tggtatgttt 3274621 gcttcttgga acatgttttt cgcaaaagga tatacagcaa atacgacaac aaacaggctg 3274681 acaccgctgt acgtcaagac agcacccatc agcacaatgg caagtatcgc tctttttgcc 3274741 ccgacaagcc ggacaattgt tttcgcgatt gatgccgcaa gcccggccat ttcaacgacc 3274801 tttccaaaaa tagcaccgag caaaaacact gggaaataca gcttaataaa acccgccatc 3274861 ttctccataa aaattgatga aaaaaaagga agcacatggc ttggatctgt cagcagcacc 3274921 gcgaataacg cgcaaatcgg cgcaaacaat atgacagaaa atccccgata cgccgtaaac 3274981 atcagcaaac ctaacgccaa tagaatgatg atcagttcca cacacacatc ccccgtttcc 3275041 gcgaactaga aagcgtttac aaaaacctgt ccgcatcggc tgtttccgtc ccctttccat 3275101 atgtacgaga agcgtgggcc aactattccg attaaaaaag gaaagctcct tttttcggag 3275161 ctttcctcta ccattcattt cattcctatt aggatatcaa catcaaccgt aatatcggct 3275221 gatttcatct ctttcagcag gctgactcga tctttcggcg ccgaccaggc aagcggcgtc 3275281 atcttgagaa gccagtggat cgcctgctgg tcaagcgttt taacatagcg cagcctgaca 3275341 ggacggctgt gtgctgcatt tgctgtaaaa cgctcaactg ctgccgtatt ggaatacgtg 3275401 cgccttggtg aatcagtata taaaaattgc cttaattcta ttaaatagtc gcttcgcggc 3275461 actactttta tgagcatgcc atcattcttc agcagtctat gaaactctgc ataattggac 3275521 ggcgaaaaaa tagacagaac aacatcaaat tggcgatcat gaaaaggagc acgcgccaca 3275581 tcggcaaccg cccacatcag atctttgaat gccttagaag cttttaagat cccgtccttc 3275641 gaaagatcta tgccggttcc tatcgctgct ttccctgcat aatcaaaccc gcaaagcgca 3275701 ttcaaatgag aaccctcacc gcaaccgctg tccaagatgg tgaatgcctc atgaccagat 3275761 ttgggatgac tgatgagctc tgcaatcgca tcatggagcg ggtcaaaaaa accacattct 3275821 ccaatcagcc tgctcctcgc ttcaaaaagc tcggcaccgt aactggtttt gaccggcttc 3275881 gtcagaaagt tcacgtagcc gtgccgagat agatcaaatg tatgtcctcg ttctgtacaa 3275941 atcaagcttt tccctgatgc cgcatccata gaagaatcgc agagcgggca tcgaaacatg 3276001 ctgaaatcaa ctgttcgctt catgataaaa aacaccccat tcattcattt ttagataaat 3276061 gaaaaaggca tagacaaata aacctaggcc tatctcaaaa attggccagg tctggcagtt 3276121 tgtctacacc tgtcattatc tataacgaat gaattggata atcatgaaaa aaactccctt 3276181 tctgctgtat gggtttcccc gtttccatca tacaacaaat atccaggagc tggaacctta 3276241 tagtgaagaa aaatcagtac tgacatgctg gtatcccgcc aacatcatat cagcatagca 3276301 atccagcatg tttttccttt attttctcat tttagaatat aaattttatt attgtgaaaa 3276361 tagttaaaaa ggttgatttt caaaaagtga aaggataaaa tactgctatc atcttagaaa 3276421 aagacattct tgtatatgat cagtaatatg gtctgattgt ttctacctag taaccgtaaa 3276481 aaactagact acaagaaagt ttgaataaat ttgaacgagt tgaaaaggac aagttctttt 3276541 ctgtttgctc ttatttttca cactttctgc acttccagaa tttgtgaagg ataagagctt 3276601 tttttgtttc cataataacc ctcataggag ttgctatcat gtacttttta ctaaaccttg 3276661 tcggtctcat tgtgattatg gcagttgtat tcctatgttc tccgcagaaa aagaaaatca 3276721 agtggcgccc gatcattacg ttaattgttc tggaattgct gattacttgg tttatgctgg 3276781 gaacaaaagt cggaagctgg gccatcggta aaatcggtga tttcttcact tggctgattg 3276841 cttgcgccag tgacggtatc gcgtttgcct ttccgtcagt gatggcgaat gaaacagtag 3276901 actttttctt tagtgcgctt cttccaatta tctttatcgt cacattcttt gatattttaa 3276961 cgtatttcgg cattttgcct tggctgattg ataaaatcgg atgggtgatt tcaaaggctt 3277021 cccgcttgcc gaaattagaa agctttttct ctattcaaat gatgttcctt ggaaataccg 3277081 aagcacttgc ggtcatccgc cagcagctta cggttttaag caacaaccgc ctgctcacat 3277141 tcggtttaat gagcatgagc agcatcagcg gctccattat cggatcttat ctttcaatgg 3277201 tgcctgcgac atacgtgttt acagccattc ctttgaactg cttaaacgcg ctgattatcg 3277261 caaacctgct gaatcctgtt cacgtgccgg aggatgaaga tatcatctat acaccgccta 3277321 aagaagagaa gaaagacttt ttctctacga tttctaacag tatgcttgtc ggcatgaaca 3277381 tggttatcgt tattttggca atggtgatcg gatatgtcgc attaacgtca gcagttaatg 3277441 gcattcttgg cgttttcgta catggcctga ccatccagac aatttttgct tatctgttca 3277501 gtccgttcgc attcctgctt ggactgccag tgcacgatgc gatgtatgtt gctcagctga 3277561 tgggcatgaa attagcaacg aacgagtttg ttgcgatgct tgacttgaaa aacaatctca 3277621 aatcccttcc gcctcacacc gttgcggtgg cgacgacatt cctgacgtcc tttgcaaact 3277681 tcagtactgt cggcatgatt tacggcacgt acaattcgat ccttgacgga gaaaagtcaa 3277741 cggtcatcgg gagaaacgtg tggaaactgc tcgtcagcgg aattgcggta tctttattaa 3277801 gtgctgcgat tgtcggcctg tttgtgtggt agaaacattg agccatatcc cttttcggat 3277861 atggctcttt tcattattga taaatagagg ctggcacctg cacatcccgg attcccgctg 3277921 cataaggccc caagtcatac tggccgaaga cgatggcgat cccgtttgcc gtaaagtaaa 3277981 acattgtgtc tctgtttagg gttatatcct ctttctttac atcagagaaa aacagcacat 3278041 cgtgtttttt gatatagcta tataggtaat ctctcgtttt gctgactttt gttttggtgt 3278101 tcagaatctg atccagcgtc acccgctttt gtgctttcaa gtcatagttg aaggactgga 3278161 cagacgttag accgtgggcg ccccctgaat agatataatt gagtgtttga atgctgagct 3278221 tgcctgccgc attgtatttg acgctgaagg atgtttgata ttcccgtttt aaagccctgc 3278281 tgttcgcctg cttttttgtt tttcaggtat tcctgatacg attgttcatg taggctttca 3278341 gctcttgatt gattttcttt tcaaacgcgg cattcccgac gtgatgcact tgtggatacg 3278401 ttaactcctt gatctttttg tacgtatggg tgctgacagt cggtgttttc gcttgaactg 3278461 cttttaaaga tggggccgca tatgcaaata cagaaaaaag caagactgca atgcccgcgg 3278521 ctttcagcat gttattccat ttcatacaat ctactccttt gatgtcgttg tttatcattc 3278581 ccttatttaa gcaatacaca cttttataga ctgattaaat cgaaagaagt ttctaggtct 3278641 aacagcatga tttttccaat aaaaaaagag acacaggatg tctctttttt tactgtttgc 3278701 gcccagaaat cgcttcatga agggcttgtg ccaaatctgt atttccgaac atctctaata 3278761 ccgcaatgac agtctggtcc ggaatgtgct ctgcttcgtg ttttggcacg accagatcgt 3278821 ccatggtttt tttcaagctt tcattcagct tttgctgcgg atacgctttg gcgtacagct 3278881 ccatcggatc aagatcatgg ttcacgcacc actgggcaaa caccaaaatc atcatatttt 3278941 catcgcgttc gtaagcttca gtgagctgtt tttcgttcat ttgtcatgct ccttatgaaa 3279001 agtatcttcc ttaaagatac aggagccgat caaattcgtc tatcccaatg gcgatgagca 3279061 gcaaccgcat cgataaatgc cttgctgaaa gcggtgtagt caggttcatc tttagccgtt 3279121 acgatgccta gcccctctgt tgtcccgaca gaggattgaa gaaggtcaat tccttcattt 3279181 gccgcaccga tcgccttgta gtgattgtaa gcttctctga taaacgccat cgcttgtttg 3279241 ttgtctttta actccagtcc tcctgcggca tagacggcat catacagaac agaatcaacc 3279301 gtcaggaacg tgccgctggc ctcaagctgc tgtccgctgc cgcttgtcat ataccccaga 3279361 ttttgactga tgatatccac tgtgattcct tcttgcttta aggcttccag tactgtttgc 3279421 agctcttttt catgaaatcc gtttccggcg agtacagcga cttttcttgt tgacgcggtt 3279481 ttcactgtac gggcttggct taacgcaggc gaagtaagaa tttctttaga tgctttacgc 3279541 ttcgcgggcg ccgccacgcc tactcctttg gcgatttctt ctgctaaatc tgcatcgaca 3279601 ttgctgaaga catcaacgac ctgccgctgt acgtctttgc ttttgacctt cccgacctcg 3279661 aagcagaaag cagaaatgat gtgctgtttc tccacaggag acatgctgtt ccagaaaagc 3279721 ttcgcctgtg agtaataatc gttgaagctg tcgcttcgct ggcggatttt tttgccctcg 3279781 actttttcct gatagtggac gtagccgcct tcttcagctg tcgcaggcga cggatcattg 3279841 ttttgcagtg agtttttatg ataagcgaca ggtcccttat tgatcgtcat ccggtgatag 3279901 ccgtcgtatt ggttgttatg gaatggacag accggccggt taatcggaat ctcatggaag 3279961 ttcgggccgc caagacggat gagctgtgta tccgtataag agaaaagccg cccctgcaat 3280021 agcgggtcat tggtaaaatc gatgcccggc acgacatttc ccgggtggaa tgcgacttgt 3280081 tctgtttccg caaacacatt atcctgattg cggttcagcg tcatttttcc aatgatcttc 3280141 accggcacaa gctcttccgg ccacagctta gttgggtcaa gaatatcaaa atcaaacttg 3280201 aattcatctt cctcatcaat catctgcacg ccgagctcgt attcaacctt gccgccgttt 3280261 tcaattgttt cccacaggtc acggcggtgg aaatctggat ctttcccggc aattttttgc 3280321 gcttcatccc atacgagaga atgcacgccg agcaccggct tccagtgaaa tttcacgaaa 3280381 cgtgcctttc cttgttcatt gacaaaacgg aacgtgtgaa cgccgaagcc ttccatcatt 3280441 ctgtagctgc gcgggatgcc tctgtcagac atcgtccaca tcaccatgtg ggcagactca 3280501 gggttattgg cgacaaaatc ccaaaatgta tcgtgagcag tcgcagcctg aggcatttca 3280561 ttgtgtggct caggcttaaa cgcgtgaacc aaatccggaa atttgattgc gtcctgaatg 3280621 aaaaacaccg gaatgttatt tcccacaagg tcatagtttc cttcttcagt ataaaatttt 3280681 gtcgcaaagc ctctggcatc ccgcaccgtg tctgcggagc ctttagaacc cgcaaccgta 3280741 gaaaaacgga caaataccgg tgtcttcacc gaagggtcct gaagaaattt ggcccgtgtg 3280801 tattccgtca ttggttcgta aacctgaaaa aagccatgca cgccaaatcc gcgcgcatgc 3280861 acaacgcgct ccggaatcct ctcatggtca aagtgcgtca ttttctcccg gaaatgaaaa 3280921 tcctccatca gcgtcgggcc gcgaaccccg gcttttaacg agtgctcatc ctctgacact 3280981 cgcaagcctt ggtttgtcgt cattttcttc ccgctgttat cggtcctgta ctgctcaagc 3281041 tgctcgtcct ttgagtgttc atttacacgt ttgttttggt catcactcat gtctgctccc 3281101 cctttttaaa acgaaacatt ctacagcaca tttacccgtg gcgttcttca tataaactgc 3281161 taatccgctc attaggattt ttggtctaca tataaatatg cggtcataca catttgaaat 3281221 aagccttctt cacagaaaga aaggatggaa gcgcttacca aaaaagctgt tgaatagggg 3281281 aggtcatatc atgcttgcca tactcggttt tgtgatgatg attgtcttta tgtaccttat 3281341 tatgtctaac cggctttccg ctcttattgc tttgattgtc gttcctattg tgtttgccct 3281401 gatcagcgga tttggcaaag atctcggcga gatgatgatt cagggcgtta cagacctcgc 3281461 ccctaccggt atcatgctgt tattcgccat cctgtatttc ggcattatga ttgactcagg 3281521 cctgtttgat cctctcattg ccaaaatctt atcgtttgtc aaaggagatc cgttaaaaat 3281581 cgccgtaggc acagcggttc tgaccatgac catttcgctg gacggagatg ggacaacaac 3281641 ctatatgatt accattgcag cgatgctgcc tctctacaaa cggctcggca tgaaccgttt 3281701 ggtgttagcg ggaatagcga tgcttggttc gggggttatg aatattatcc cgtggggcgg 3281761 gccgactgcg agggttttgg cttccttaaa attggacacg tcagaggtct ttacaccgct 3281821 gattcccgct atgatcgccg gcattctctg ggtgatcgcc gttgcttata tcctcggaaa 3281881 gaaagagcgg aagcggctcg gcgtcatttc gattgatcac gcaccgtctt ccgacccgga 3281941 ggccgcaccg ctcaagcgtc ccgctcttca atggtttaac ctgctgctga ctgtcgctct 3282001 gatggccgca ctgatcacca gcctgctgcc gctccctgtt ctttttatga ctgcgttcgc 3282061 cgttgccttg atggttaact atccaaatgt caaagagcag cagaaacgaa tctcggcgca 3282121 tgcgggtaat gcgttaaacg ttgtctcaat ggtgtttgct gcgggcatat tcacaggcat 3282181 tctctccggc acaaaaatgg tggatgccat ggcgcattct ctcgtttcac tcatccctga 3282241 tgccatgggc ccgcacctgc cgttgatcac tgcgatcgtc agcatgccct tcaccttttt 3282301 catgtcgaat gacgcctttt acttcggtgt ccttcccatc atcgccgaag ccgcttccgc 3282361 ttacggaata gacgccgctg aaatcgggag ggcctccttg ctggggcagc ctgtgcatct 3282421 gctcagcccg cttgtgcctt ccacctatct attggtagga atggcaggcg tcagctttgg 3282481 cgaccatcaa aaattcacta ttaaatgggc cgtgggaaca acgattgtga tgaccattgc 3282541 ggcgcttttg attgggatta tttctttcta aatgtatgag cttgatcgta gcattgagtg 3282601 agtacgtgat ttacagaggg gagaagatca aataggatat tatgagtgaa tagaagattc 3282661 atgccaacaa cttctcatta caatcataag agcctgctat attgcagcag gctctttcac 3282721 atttggcatt atttttttgt atagcgcacc cagtcataat gagcgtatag cggatttaca 3282781 ccattgtagg agccaagcca ttcatcgaca cccgtgccat tccacaagtt catcatgatc 3282841 tttccaggtg ttgtcggaat ttggtttgtt gcagtatgtt ttaattgccc gtcgacatac 3282901 catttaatag agtttggctg ccaatcgaat gcatacgtat gataggcatt ggctgcatca 3282961 aacccgagat caacaatctt ctcatggttt cctgcaccat ttgtataata gttaaattga 3283021 accttcgttg tgtcttttcc taaaaattcg atatcaatct catcccaagg agttccatct 3283081 gttggacctg tgtaagtgaa gaacgatgaa acgatccctg tgtttttagc tggtttcatt 3283141 ctgacttcat aaagtccata gccatatgtt tgaacagaac ggttttcccc gcagtcaaac 3283201 ttgttataag ctgggcttgt tagcgctaaa cgcatttcac ccaatgacgt cattgatacg 3283261 ttattagccc gccacgtgca gttgaacata tttccattcg aataaccatc tgctttttgc 3283321 caaaaaccgg agttatagcc gttaaaaggg tcaaaaaacg atccacctgt ttgagctgag 3283381 gcagtagcag tgactgcaaa caaactcata aacaatccag tgacaagaag cagcaacact 3283441 cgtttcagat aaggcatatt ggcattcccc tttcattgaa agcgttttct atgttgatct 3283501 tacatgattc ttttaaaagg gaacatcggt caaaataatg ataatatcga atcttactaa 3283561 cttgaatcct gtaactatca tcatcttccc tctgaaaaaa ataaaaacct aaattaccat 3283621 cagcacagac agagatgatc cgcactcatt gcaatttagg ttttgcctgc tttatcagta 3283681 acaatcctac cattttcata tgtgaatgta agaaaaagtg aacacaagga aacacaaatg 3283741 tcagcgctct cattatgctt gtttaactac cctttctatg tgaatggtta aatacagcag 3283801 ctcgtcactt gtgagcttgt gctcatactc ccgctcaatg taggtttgga ttttcttcgt 3283861 gcattcatac gcgcgatgat acttttcttt cactgtatcc agcaaaaaat cgtcctggct 3283921 ttccatgtga gtgccgttaa atagacgctg cgcgaaaaac tttaagtggg tgacgaaccg 3283981 ataatagtga agcgattctt cgttgaattc aatcttaaaa tggtatttta caatactcaa 3284041 aatctcttgc atgacttttg taatgttgat aatattgggc atctcttcat tcagctcggc 3284101 atttacaata tgcagagcaa taaagcctgc ttcatcctct ggcagagaca caccagtctt 3284161 gttttttacc ataaccaacg cttctttgcc gatcgcaaat tcgtctttgt agagccgttt 3284221 tgtttcccac agcaaggcgt ttttgatatc aagccctttc tggttgcgct ggatggcaaa 3284281 gttaatatgg tcggtcagcg acacatagat gctgtcgttg agctttttgc cgagctgtaa 3284341 ttttgcgtag ctgataatct cttcggatac ttccatacac tcgatcggta tatcatacaa 3284401 aagggttttg aacttttctg atacatcctt gttatcgagc gtgaacactt tctcaatgcg 3284461 ggcttcatcg acatcatcgc cggacttttt ctgaaacgcg agccccctgc ccatgacgac 3284521 caattctttc ccctgttcat tgaccacgct gatcacatta ttgttgatca ccttcgcaat 3284581 tttcatggca tgtccctcca aatctactaa gaacagacta tatcttgatt gtacattctt 3284641 tttgtactag gtcaatatca tcagggaaag acggaagctg gtcagtacaa ttcactccgt 3284701 acctgctgcc cgggctgttt ttgaagcagc gcctccagat ggcgttcaaa tgatgccttg 3284761 tcagctttct gctttttgac aatgctgttc atgattttaa tgctttcagc actgtattgt 3284821 gtatattgtt ttttcagctg atccagctgc tgtcttgtct tcttcgcgtt tttcggtgtg 3284881 acttggttga tgagtttgat catactgtct gcggtctcaa aaaaaccggc tctattttct 3284941 gtcagctgct gaatttcgat gcggctcata tcttgattac gcgttttttg aagcaaggca 3285001 accgcctcgc tgttttgttt tttgagcgat ttgttctcaa gcttaatcga ttcgagattc 3285061 tccttcgcaa tgtctgcttc ttcttcagtc atgctgattc gcacgaagta ttctggattg 3285121 ccgattccat aatcaaatgc ttcgctcact tgtatcatgg aactgaacac aatggccagc 3285181 tgcctgtcgc ttgcgagggc ttggaaatcc tgctttttct tactgctcat cggtttggct 3285241 gcggtttgtt ttactgtctt ttgatcacag tctgcgaaca tctgagcctc accttcactt 3285301 tcgcatgcgc tcatcacaag aactgtgacc agcaggctta tacacaagcc tattcgcctc 3285361 atgctctgtc tcctctctgc tgaatccctt ctggaaaata ccataaaata tagttaaatg 3285421 gtaccagatg cacctaaccc cagcaataaa tcaaaagtat gatttgaagc gaaaaaacat 3285481 aaatattttg taaaaattga cgtgcattcc attcttttca ggcccatttc tcgtacaata 3285541 gaagtatcgt taccggagag gggctctgat gatgaaacgt tttacgaaac aagaaaacag 3285601 ctgggtgtta tatgactggg caaattcagc ttactcaatt gtcgtgacca ccgcggtatt 3285661 tccgttattt tataaatcag cagctgcgga aagcggtgtc agcgccgctc aatcgactgc 3285721 ctatctgggc tataccattg cgatttcaac gtttattctt gcgatgctcg gccctatttt 3285781 aggcacaatc gccgactatg aagggtgcaa gaaaaagttc ttcggtttct ttgtgtcagc 3285841 cggtgtcgcc agcaccgcga tgctcgcctt tatccctagt gaacattggc tgctattgtt 3285901 gctgttttat acggtatcgg ctatcggttt ttccggcgcc aatgtgtttt atgatgcctt 3285961 tctcgtggac gtcacgcctg agaagcggat gaatctcgtc tcggcacggg gttttggctt 3286021 aggatacatt ggaagcacga ttccatttat catcagtatt gctgtcatcc tgctcgcaca 3286081 agcagagact attccagtgt ctgtatcggc cgcaagccag ctgtccttct tcataacggc 3286141 tgcctggtgg gggctgttca ccatcccaat gattaaacat gtccatcaac gctattacat 3286201 caaaaaagaa cctcatattg tcatcaacag ctttaagcgg ctcggccaaa cgatgaaacg 3286261 gatcaggcaa taccgggcac ttttcctctt cttgctcgct tatttctttt atatcgacgg 3286321 agtcggcacg attattacga tgtcgacatc ctatggatca gatttaggga tcggctcctc 3286381 aagccttctg atcatcctat ttgtcaccca ggtagtcgcc gcgccgtttt cgattatata 3286441 cggaaaactg gcagaacgct tcacggggaa gaccatgctg tacgtcggga tcgtcattta 3286501 tatgatcgtc tgcgtgtatg cctattttat ggagacaacg cttgatttct ggatactggc 3286561 tatgcttgtc gccacctcgc aaggcggtat tcaagcccta agccgttcct atttcgccaa 3286621 gcttgtgcca aagcgccacg ccaatgaatt ctttggcttc tacaacattt ttggaaaatt 3286681 cgcctcaatt atggggccgc tgctcattgc cgttaccgcc cagctgaccg gtaaatcctc 3286741 gactgcggtg ttcagcctga tcattttgtt tgtgattggt attgtgattc ttgcctttgt 3286801 tcccgaggaa accagcacag atgtcagcca gcagcaaaat gacctgcccc tttaactggg 3286861 agcaggtcat tcatcattta ttcgctttat tcaccttcag ctgtttccct ttgacggttg 3286921 tgttcttcat cactttgaga acatgagggc ctttaccatt taaaatctca acgtatgagg 3286981 cgttatccat gatcgtgatg atgccgatgt cgtcagctga cacaccgtca attttggcaa 3287041 tcgttcctac aaaatcaacg gctctgattt tctttttctt tccgccgtta aaatacagct 3287101 tcataatgtc tttattcagc tcttcgcttt tgtccttttt gctttccgga cggtcattca 3287161 gtttagctag aaattctggt ttcttccttg ccacttcctc ttgagaaggt gcttctattt 3287221 tttggatttc aaatccgata tattcttcaa tgtcggctaa aaaccgtttt tcgaaggccg 3287281 tgacaaacga aatggccttt cctttgttcc ctgcgcgtcc cgttcggccc gtgcggtgga 3287341 catagctttc tttttcaagc ggcagatcat agttgatgac aagggagata ttttcaatat 3287401 caatcccgcg cgcggcgaca tccgtcgcca ctaagtaacg gtactcgcca cgtttaaatt 3287461 cattcatgac gtcgaatcgg tcttcctgaa tcattccgcc gtgaatttta tcgcatggat 3287521 atcccaagtc atccaattca tcggtcagct gattgacgtg ctccttcgtt cggcagaaaa 3287581 tgatgcagct gtcgggattc tccgtcatca gcacatcttt cagcaatgaa aacttattct 3287641 cttctcttac ttgaatcacc gcatgttcaa tatttcttgt ggttaggccg gccgctttga 3287701 cctcgatatg ctcggggttt tgcatatatt gacggctcag cttctcgata tcctgcggaa 3287761 gcgtcgctga aaacagcatc gtcgtacgct cagtcggcag atgcttgata atcgcctcca 3287821 cctgctcaat gaagcccata ttcagcatct catccgcttc atcaatgacc aaataagaga 3287881 gacgatccaa cggcagcgtg cctttttcga tatgatccag aacacgtccc ggcgtgccga 3287941 caacaatgtg gcttttttgc ttaagctcag ctttttgttt atcaaaggag gattttccaa 3288001 atacggctgt cgctttgatc cgtttaaatc gtccgatgtt cgtgatatct tcctttactt 3288061 gcaccgcaag ctcacgggtc ggtgttaaaa taagcgcctg cggcttgttt tcatcccaat 3288121 tcgccagctc acagagagga atcccgaacg aagccgtttt cccgcttcct gtctgtgatt 3288181 tgacgacaag atcctttcgt tcaagggcag cggggatcac actctgctgc accttggtcg 3288241 gttctgtata tcccagtcct tccaatgctc gtaaaatgtc atgactgatt tgatagtttt 3288301 taaaatgact catgtataaa ctcctgtctc ttgcagatgt tctcattata ctctaattga 3288361 ccaaggcata tgtgttttgt cgaaaaatga tgtattaaaa gccagcgatt ccctggcgtt 3288421 ttagctcctg aacagccaat cgcgccagtg cgtcggcccc cgcgcgattc gggtgcagcg 3288481 tatctccatc catataaagc ccgagtgttc tttccggacc gatcgatgta aagtatgccg 3288541 agctgaggac atttaagtca atgagatatg ttttttcctc ttcggccaaa gctaaaatag 3288601 aggccctgta ccatctgttt acagacgaat ggatgccttc agaagtaaaa tcggttgccc 3288661 ggccctgagg cgttgatagg atgacgtccg ctcctttcgc ttttacctga cgaatcatat 3288721 cacgcatcac ctctttaaac tccgcttcag attctttatg cttcggattt gtgtcattaa 3288781 tgccaagctg caacataaaa taatctccgg gtttaatata cttcagaatc gcctcaagct 3288841 gtccatcatt tctgaaccct ctcgcgatct gcccgccaga cgccatgttt ctcacttgaa 3288901 aggtgtgttt atcgatatag tgaggcagca tctgccccca gcccgcctgc ttgctgctgt 3288961 tgagcggata ataattgcac accgtcgagt cgccgccgac ataaatggtt cgattcgtta 3289021 ccggctgatc agacaatttc tttattttca aggcgctgag cgtaaaagcg gtgcctgcct 3289081 ttccctctgt caccagcaga ttcagctgcc cgtcggtgac gggaatttgg aacgtatcct 3289141 ccgcgccatc ccctgtcata ttgatgacct gaaacacgcc ctccgctgcc acactggccc 3289201 ttgccgtatt gccaagcgtc accttcacct cataaaggcc attcgggaga tcaacattaa 3289261 acgtgttatt gcttttcgtc ccatacgcta aaaactgaac cgcatcactc ttcacaccag 3289321 ccccggatgc cgccacatcc ctcatattct ccggtgtttg aaaaccgtag ccctttgacc 3289381 ggtcataccg atcagacgcc ctgacaccaa tataaccagg ctccatcgaa ccgcttccaa 3289441 agtcaaactg atacaccttc ggctccgccg ccttcacatt ctcaatcccg ccaaaacaca 3289501 gcatcagcat catcacaaaa accgctgcca tccatttttt catcaagact ccccctctat 3289561 gaaaacgaat acattaatgc atactcggtg attgtttctt tatgatgact gaattaagaa 3289621 aaaaattgcg ttgaggaata aaaatgaggg gagagtctca agaaggggaa aatcagtgtg 3289681 acttcttgtc acacttgatc acatcccaac ctccgcaata gaagcttatt tggttttctt 3289741 cgtcatacac ataataacgg agtctttccc attgatcgtc agtcggtaca atctccaatg 3289801 caaccgaatc gatggattca aggtcatcca gctttgatgc actaatgttt tcaaaccgca 3289861 attgaatgtc acaggtttga gcagatcgtt ttcattcaaa cacaggaata tgaatataac 3289921 gatcatcttc tttcatatag aaagaaaact cgtttaatgt aaatggacct gtatcctcat 3289981 cagaaagatg ctgtttcaat ttctcgtatt gtgtgatatt caaatgaatt ccctctattt 3290041 atatgattca ccgccaatca tataaatgtc cacagcatcg tattcaaacc atatgatccg 3290101 ttcgcctgag tccgttaggc attggagctt cccttctgaa aaatagcttt tatccggttg 3290161 aggatcagtg atcagaaaaa catcatcatt gatggaagct agcagaaaga gaaaatctgc 3290221 aatatcccgg tctgcttcct gtaatatgga ttggaaatgg aattcccttt tggccagctt 3290281 cgtcaccttg taagcatgac cttcaaaata ctcggacagg tcttctataa atgaaccagt 3290341 cgttattacc tgtatcatga ttcgatcgta ggcaagccct gcccaaaaac gataaaacga 3290401 ctctgcatct tcaagttcgc atgccataac ggtttggtca ggcttaagct cgatcatgtc 3290461 caaattgcca atactgctta tagaggttat ttccataaaa tcttcccctt atcagttgga 3290521 tagcgcaacg caaatctctt gtctgacttg ttcatacaag agaatgtgat gatacagatc 3290581 cttatcgttt ttgatcatat ccggaagtat gtcaggatac agctcaaaaa agcttttctc 3290641 caacgaacgc cgctgatgcc ggggtatcct tttattcgcc agcacataat ccaaactgcc 3290701 agcaacaagc ataaaaaact catagatttc cgcttcaaag ccgtacaatt catcagggta 3290761 ctgcttttct tcaagctctc gctgtctttt tctcagtttt tgaagcacgt tgatcctctc 3290821 ccttccgcaa taatctcatt tatttcgaaa cagaataggc ggatcattat ctatcgcctc 3290881 caacagctct tcaccaaaca cagtgattgc acatttccac gggtctccca aaagtcccca 3290941 ggagaagtcc tgatgaaaaa agaaataata gtctccattt ggaaatacgg gaacaggcca 3291001 ttcgccaaat tcatccttag gcattgcctg atgaggacta aaggtatatc cgtcatgctg 3291061 ccaatctagt gcgtacatta catcgttctt tccagtacct aattgaaatg cttttaaaat 3291121 agaagtctct aaatcactta gcactccgct cacatcatta tgaccagctt tactgctcat 3291181 cgcgcttgag atatcaaaca ctcgatatgg atcaggcggg atgatgtgat gacatctgct 3291241 tccgggcttc cattttatga tcttgttcac ttctgaccag atgcggtctt gttttgtctg 3291301 acttaaagcg cgccaattca tcataatctc atccctacac cttattggat atcctgctta 3291361 taaacaccag aagaggccac tgcgtaaaca gcgtaacttg tcagtttcag ctgttgaaca 3291421 tctaggcctt caccgttcga atcacagcat gttatctctt ccatctcttg actcacatcg 3291481 gcagaaatca aataaagaga cgacttaagg tctgcactgt aacaattgaa cgtcccaacc 3291541 aaaaaacctt cttcggatat cgcgagctga tcaaatgctt ctgagtccgg ctctttatcc 3291601 gacagaatcc acacccgtct cacgaccgtt tcatcaaatg cggcaatgac tgcatctccg 3291661 taatacagca tataaatcaa gccgtttttt tctgcaagtc cataacaatc atctacagca 3291721 ggcgcatcca tttcttcaag ctttctatca atgtgtattt ccttctgctg accatctaac 3291781 gtaaaacacc acacactatg gccgttggga ttctcatcat gataaatccc ttcatcacat 3291841 aaaccgaccc aaagctgttg tttctaatcc aaaagacagc aggaaacccc tgaaggcaag 3291901 tgaaaaacac ttttcaccct tccctcttct gaaaaaacct ttaccttcgg ctcgtacgat 3291961 tcgtaataaa cgaagacata gccatctgca cattgttgaa agagcagaat atcactgtat 3292021 gaaatctgct ctttcactct aaaatcccga acatcaccgg aaggatcata gattgtaatg 3292081 gtgataccac ctttcaaccc ttttccaatg tagacacgcc cctgtggatc agcatggaaa 3292141 aaacaatctt gggtgttctc gttgatgatt ttattcaatt ttaatttttt cattggttat 3292201 gctcctaggt tcgaaatgaa atgataagaa taaaccattt attagctatt agtaacggac 3292261 aacctagttt cattaatcgt tttgggataa atctactttc caattcagcc ttaaatcatt 3292321 tagtgtttaa ttggtatgca taaaacgatt gatcatcaaa gcgaactgtt tcagcttcta 3292381 tagcaatcag cattctgttc atgtcaataa gaaagttagc atttgattga tactccggaa 3292441 ttatagaatt tgatagattc ccgattcctt ctggatgata actcatctca aatacttgcc 3292501 aattgtattc ttccggatct attttttcca atctcatgtc gccaacatct gcactataat 3292561 aagcggatgc cacattttga aatgaaattt tatgcgtata ttcaccttca tcttcaaaaa 3292621 ccttaatatc aagtgagagt tcttttttaa acacattaaa atctaaatga aggacactgc 3292681 accccttatc tatataatca acccattcat taatcgtttg atacattgtc atcccctgcc 3292741 tctttttaaa caataacgcc ttgccaccaa gcagaaaaca aattactccg tatattgttt 3292801 gatccaatca tttaaatcat ctgttgaatg caaataagtt tctgatgaat ctttcaaatc 3292861 aatcccactt agaaggatta acatatccca gactctatcg tcttctactt cggggtcatc 3292921 cgcataaaca taagttccag cccaatccga cacttcttct cttgttgttt gtccatttaa 3292981 gacacttttg attttattta tgcattctat tagatttgtc tcgctcaatt tgatcaccac 3293041 gtattcaagt actaaatgat tttttattag tatgcaaagc accgtactga tatttagata 3293101 ttgaagcttt ttccgtaaaa gatatgttcc aaaaggtttc caatctacca ataaacaagc 3293161 tcacatccgt attccgtgtg caatatacat aaaccaaact ggcacttagg ctcaaccaaa 3293221 ataaaactat gattgagaat cccttcatcg aactcaatac actccaataa gcagtcaagg 3293281 tgctcgagac attttccaaa agaacaaact aacgcaccaa tttcgctgct gtattgatga 3293341 aacagcagaa cgtcccggtc atcgtaagca acatatgact gagatatttt ccagatcagc 3293401 tgtttcgctt ccgttttttc gagggcatca acctcacggg tgttggctgg tattgaattt 3293461 gataaaacca gctcaagcaa ttgcctgctt tgcgccagat cagcaaaacg ataagtgaag 3293521 cctctttctg cacaagggac tagtttttct ttgatttcgc tcatcaataa acgtctttta 3293581 ttctcggcga gtttttcgat caatcttttt tgcatgagcc gcattccctc cgctgtcaat 3293641 ttctcaactt cttttaaatt gattcatcat tctcttgttt tcgttgtcgt tcatgtttag 3293701 atttgttcta aaaaagcttg tatcgcttat cgatacaagc tttatcttca actgcttaaa 3293761 actcacccag tgggcttttc acaaaacgct gggaaccttt ttggcaaatc ctcttcatcc 3293821 caatcaattc tatattttta gattcttttg tcatacaaat aagagaggat ggtaacatct 3293881 cttatttaat gttccatcaa taaatgcccc atttttatcc aatgcagaaa ttatttataa 3293941 ttaaggaagt ttagaaggat tttttgtatt ttcaagattt aattttaaag cggtcacaaa 3294001 agactctagc ttttcttcat tacaattaat ttcgaacaag ttggagttcg acttactttc 3294061 tttataatca tcaaatataa ttttaatctt aattctgtaa tttccgtttt cttgatcaat 3294121 actaagaaat aagaatggtt caatagtctc taaactgata ctgtcttgat ttccttttat 3294181 catagtttcg atcccagata tcaacacctt atattcactt tctaataaaa cagcagaaaa 3294241 atcgcgaacg acggctttct tattttccaa caattcaaat acagataaaa taaatggatc 3294301 atcgtccaac tcttgatacc ttctcggtgt taattcaagt tctatacaat catcttttat 3294361 tttggccata tttcctcctc atttaaagtt taagtgaggg tagttgtcat ccccccctcg 3294421 cttaacctta ttaacgcctt ctcttagatt tatttccttt tccgtgtgta tggaatacgt 3294481 gtttagaacc cttagctctt gaacttccat aagctgtgat tactttaccc cttttattta 3294541 aaacaactgt agcttttttt ccaacatatt tcgttgcccc attaggttgt tttattactt 3294601 ttttagggct tcgcacagca ttcagtttgg cccttaaatt gactccacgg cctccatttc 3294661 ttcctataga ttgattaagt ccatgtcttg tatgacctgt gattttaact gccttcttcg 3294721 taaacttata ggcgcgacta gcacccttaa atatcttccc aggaccaaaa ttagaagcag 3294781 ctgcccaagc agcacctttc catcctttac ctgatttata tgccttatat ccatcatagg 3294841 ctgcaaatcc ggcatttacc acaagccata cccaatgccc gtccggatca acattcatca 3294901 ctgggttatt atttccataa gcatacccat tctgatccaa tgaatctccg tcgctgcccg 3294961 ggtctgggtc gagcgatagg aacacgccgt ttcttggctc gtagtagcgg gccatgagat 3295021 agtacaggcc ggtttcttcg tcgtattggt agcctgcgta gcggtagcga ttgtctttta 3295081 cttcgtcgct tgcttcggtt tttgttggat ttccccatgc gtcgtattga tacttggcaa 3295141 cggtttttcc agtgctgtct gagatcgcga tgatgtcgcc gtgagcgttg tagtgataga 3295201 aatatttctt accattttct gtgtaggata acagctggcc gctgtctccg tacgtgtatg 3295261 attttgtgac gttgttgtcc gcgtctgttt catacaagac gttcaagctg tctccgtcgt 3295321 agaagtagtt cgtgactttt ccgttgacgg ttttttggat tctgtttcct ttttcgtcat 3295381 acttatatgt tgcgaatggc ttgtcttcgc cttttttggt aacggcggtc aggttatctt 3295441 ctgcatccca cgtatatgtg aatttgccgt cggatgtgcg gttgccgttt ttatcgtaag 3295501 agatgctttc atcattgact tttgtcagct ggttcatgat gttgaaggaa gcgttcaccg 3295561 ttttgcttga gccgtctttt atagttgtaa cggttttccg gtttccgaat ccatcatatg 3295621 tgtattcaat aacagtaccg tcttcatggg tttctttgac aagctgattc agcttcccat 3295681 actcatattg caccttgccg cttgctgagc tgtttatcgt tgtgcggttg ccgttggcat 3295741 catattcata gctttccgtc agaatgtctc cgccgttttt gtcaccgata tgcagcgagc 3295801 ttacaaggtt tctttcgtca tatgaaaaac ttgttccgcc gccgttgccc gtaataaagg 3295861 tttggacgtt tccattttca tcataatcaa atgaatatga ggatgtactg tctttcatct 3295921 caatcatttg atccagcttg ttatacgtaa attgattcgt tcctttttgg tccccatgaa 3295981 tccacgagaa ggttttcagc ttatcggagt cactaggata tgtccaagtt tggctgccgc 3296041 cgcggtctgt cagttcggtt aaacggtttt tgttgtcaaa tgtccgtttc tttgtggtgt 3296101 tctgctcttt attgacgacc gacgtttcat ttccattttt gtcatacgtg aaaatgtact 3296161 tttctgtacc gttatacgac tttgatttca cccggtctgt tccatcataa gaaagagaca 3296221 cttcgttgcc atttggtgaa atggttttgg tcaggttgct gttggcatca tattcgcttg 3296281 ctaacacatt gccgagaggg tcagttgttt tgacaagctt gcccatgaca tcatattcga 3296341 atttataggt ttgatctgct cctgcccgga tggttttgct tacctcattg ccttccttat 3296401 catagctgtg aaggatagac gtgccgttag agagcgtcat gtttgtcaat tggtctgcct 3296461 gatcatacgt ataggttgtt ttttcacctt ttgcatctgt ttcagacgtt ttcttaccag 3296521 tttcatcgta atcagttgaa gtggcgtaac ctagttcgtc ctcttccttg gtcacatagt 3296581 tgccattact gtcatacgtg cttttagtca gaaggcttcc ttcaatcaaa cggatatcat 3296641 caaaccagac tgtgcctgtc gcactctttt ggaacagaat actgatatcg actttattga 3296701 tcggctttgt tttagggatg acgacagctg ctcggttcca ttcctgtgtt ccagaaggga 3296761 atttcgcatt gtagatgcct gtgctgccgt cagcgtaagt gacattcgcc tgcagagaat 3296821 agtctttttc atctgtaaat ttgacgctgc ttgctttcga cattcctgtc agtgtgagat 3296881 aaaccggttt gtcatttgcg ctttgcccta agacaacggt ttgttttgtt actgatccgg 3296941 cttgggacgc actggtccgg gcagctttta atgatacatc atcattaaag ccttcttcag 3297001 aatcaacgga tgctccgctt acattccagt tttccgttgc tgatgtgaag ctgctgtttt 3297061 gaactgggtt atagcttgat gatacttcgc ctttttccag ctggacttca tcaaaccatg 3297121 cttttccttt gccatcttta tctttatgat cgacttccat atacacaaca gctttgcctg 3297181 cattcgctgg agtcgtaaaa gtgatttgcc gttttgtcca gtcatttttt ccggctaatg 3297241 cactgtattc attgtgaatc cattgaattc gtttttgatc tttgtctcgc aaatcaatgt 3297301 taaaataggc tcttgatttc gcaagatctg ttttgatttt cccgcttaat gtataggttg 3297361 tattcggctc cagctcaact gtttgtgttg ctgacgaata cccatgatct gttccggcag 3297421 acgttgattg gctcaagacc tccaatgcct ttgatccgga aagaactccg cttttatcgg 3297481 cgatgactga aattttgccg ctgtctttag aggcagtcag attccagccg gatttttgag 3297541 cttcaaagct tccatctttc aaaatattag ttgaagctga taaatctttg ctcgattgaa 3297601 tctggtttcc atatttatca taaacagctg ctgacgatga ttttccgctc tgatcggttt 3297661 cggatacagc atccagtccg tcataagcaa tatccgtgac attgccctcg gtatccttca 3297721 tctttgtgac atcgttgttt ttgttgtatt cgtatgtctc agttccatat gcatctttaa 3297781 ccgacgtaac gttgccatct ttgtcatatt gatagctttc cgttgctttt ccggtgccga 3297841 cgtcatttgg atctacatct tctacaacat tgttgccttc atactttgta ttcgttgtaa 3297901 tttttaaccc ttccgcatca tcaatgacct gaatcggatt tcccgcttca ttatagccat 3297961 actgtacttt ccggccattt ggctgtgtca tgagaagcgt ctttttatca gcatcatagc 3298021 tgtagacata tgtttctttt ttagcgttga tcgctttttc gagacggtga ccgctatact 3298081 gatattcggt aaagacaggc tttgcttcgg tactgttagc tgaatattgt ttgacaaggc 3298141 gcccttcact atcgtagtca tagcttgtga cagtcccgtc tgtatctgta accttcttca 3298201 gcaaatcatt ctcatatgag taggtgactt tcttattctt aggtcctgtg atggacgtca 3298261 catggccgtt ttcatcatag gtaaatgtaa gcttgcggcc tgatgcatct gtaatggcgg 3298321 tcagttgatt tttgtcattg taagtataga cagttgcatt gttatggcca tccactacct 3298381 tttggagttt gccgcctttt ttattgaaat aagcgttggt ttgatccttt gtttttaata 3298441 tgaactgatc agctgtttct gttaattcaa gatatacacc ggtcggcggc tgatacgtgc 3298501 catcggcttt tttcgtgaat cgatgtgtcg tagcgtcttc atcgatatac attgccccgc 3298561 catccgttga gatgacagat gtttctgcat cagcatacca gccttgtcca aataagtgat 3298621 cagagctgtc aagactgttg taggttctcg ataagccaag tcccggaccg cgtccatcaa 3298681 ttgacaaatc ttcttcattc acaatgacat tgcctgtcgc accatttaac tggccgcttg 3298741 ggatatcaat gatagaccag tactcttctg tacctaggaa ttctgcgcct tcatggaacg 3298801 ttgggttaaa gggcgccgtt ggaatcgttt caccattcgc atcataggcg acaagcgtga 3298861 aagaataatt cttcttccct ttgtaattcc catttgcatt gttatagaca ggtgatggat 3298921 cgagggctaa ttccccgcct tttccatctg tatgaagctt atagcttccg gctttgattt 3298981 cctcagaagt cggccagatg tttttatttt gggttgtcca atgatcagca tcaccaacat 3299041 caaaggactg atattcttta ccgttgtaaa tgttaacttt atagcccttc gcattttgaa 3299101 ccttttccca tatcaaattc acataacccg tttgactcga ttttgtattt gtatacaaat 3299161 agccagttac attctttggc ctagcgatat caggaagtgc cggggtagca gccggggatg 3299221 caatggcttc gccgtctttg ttgtatgcga taattttaaa cgagtaattt cttttggctc 3299281 catctccccc ggcgttttta taggttggtc cgggattgat cggcagctct gctccgcttc 3299341 cgtcctttag gtgaagagca tattttcccg ccttgatttc tgcacttgtc ggccagatct 3299401 ttttcccttt tgtggtccaa gacgtctgat ttccgagatc aagtgtctca aagcctttcc 3299461 cattgaacac ctgaacctta tagccggttg caccggatac agctttccaa gaaaggtcga 3299521 agtatcctgt ggcattccca ttattgtagc cctttgctga cggtgcttgt gcttttccta 3299581 cattagggat aacgggcttt gccggtgcgg acatcgctcc ttcaccttgg tcaaatatcg 3299641 cactgacgcc aatccaatag tttttgcttg tagcatagct tccgccggaa ttcttataga 3299701 ccggggatgg atctaatgcc aattcagctc catccttgcc gtccagatgc agtttatatc 3299761 tcttggaggc aatttctgcg ctcgtaggcc agattttttt accttttgtg ctccacgacg 3299821 tgacgttgcc tgcagaaatc gcttgatatt ccttaccatt gtaaatccat accttatatc 3299881 cttttgcgcc ttcaaccttt ttccagctga tatcgaaata accagtggaa tcgccgttgt 3299941 gataggcttt gattgtaggt gtgtttccct ttggaatggt atacgtcact tcaatatatg 3300001 gtttattggc ggagttcgct gaagaaatta gttttttcca atattccttg ccgtttccgt 3300061 ttgtatgaag cttaaatcca tagttggccc cgccggagtt ccatgacttt acagcagcgg 3300121 tcacatcata actcgcccac tgtcctttat ggacgtcggc ttttccgata tttttagatg 3300181 ccggtttggt gttccatgtc acttttgcat tatcataatt gctgttgacc gtatccagcc 3300241 aaaggccggt tgcctttgtt ccataatagg aatgggctac gtatgttttt aatgtagctt 3300301 tagtgacagt catattttga attggcttta ggttgttaaa tttcatgaac gcatagtttg 3300361 tgcctgttgt tttgtcataa tagcccgttt tcagtacata ggcctttaaa ttagcatccc 3300421 atttttgtga ggaggccgaa tagttcgtcg tcgggtaggc actcatgaca aacgtatccg 3300481 atgaaacaga taaagaagtt gacgggtcga tagatactgg atatacgcgt tctgggtctt 3300541 tcagccagtt ctcgtctgcc gtaagatgaa gcaaataccc ttcttcattc ttttccagct 3300601 tatagctgac tttgtctgac cgttcaacct cgccggaaag ctcatctagt tttgaatccg 3300661 tcataaaagg cttaggcaca gaaaaaacaa cttttccttt ttcatcagaa aaatcaatgg 3300721 atccatcctc ttgttcttta gcctgcaaat cggtttttaa ctgaaatgta aatgtgttgt 3300781 atccattata ctgatgaagg actaaatctt cttttatgtt ttcattgaat gtgaaagtct 3300841 gaagatcaat attcggaaac acatccggat acacaatctc attactgtca gtcttataat 3300901 ctgctgaggt atctttcgga gtaagtgaag ttttattcgg gcctttcgct tctgctagtg 3300961 aatatgtaac cttatggtca ttatgctcaa aagtcgcata aagcccgttc ttcatttgct 3301021 tttgaaaatc tgaattcaaa atagcgttct ctgtctcgac ttgtttgctt gtcgactctt 3301081 ttaactcagg agaaatgtct tcccagtcgg catccggtgt ttcctttgta tgaataggat 3301141 caaggtatac ttcctgttta tagacaccgt caccttcata atagagtttt gtattttctg 3301201 ttctttcaga ggtgatctca ccctctttgt ttatatcttt tggatcaaaa ggtacagctt 3301261 cctcagtttg ttctttctga agagtttctt ctggatcatc ggcagcaata cggtttccat 3301321 tctcttcttc tgtagatttt gctagtacat cggctggcac taatgaaatc attaaagcca 3301381 acactaaaaa tgctgcaatg aaccttttaa agtttcgcct ctttcttttt ttcatttcct 3301441 ctctcctttt gtaataaaag taatatttac tcaataatct taactagact gaaatatcat 3301501 tacaatattt ttctagaaaa tttatcttat tttaaggatt agcgagagtc aattgaccta 3301561 aaacaaaaaa aggccgcata ggccttttta cattttttat tgtatttgtt caatatccgt 3301621 accctcagct gtcacattcg ccttcccctg cctcctgaca agcgtcaagg ccatgcccgc 3301681 aaagatcatt acgatgccaa gcgtttgata gaggtcaggg cggaagcctg tgaagacggt 3301741 atcgagcacg atcgcgacag cggggtcgag aaatacaatg attgaaataa atttcgttga 3301801 taaaaatcgt aaactgtcaa aaaacagcaa atatacaata cccgtatgga tgatgccggt 3301861 agataccacc ataatccagt ttccctgaga taggtccgca aaagcgccaa agtgaataaa 3301921 cggaatcagg atgataaccc ctaaacctgt ctgcaagaag gtggtcgtgt aaggactgag 3301981 attgtgaatg ccttttccca ataaagtggt gaacgcataa aacagtgcgg cgagaactgc 3302041 ccatatgatc cctgatccca tcagctgtgt caatgatgtg ctgccgttaa tcccggaaat 3302101 cagcgcagtc ccaagaaagc agatgataat ggagctgacg gagatcacat ttaatttctc 3302161 tctgtagaag aagctcccca gaagaagaac aagcaccggc gctagatgat aaacagagat 3302221 ggcaattgta acggacgttt cttcaaaaga cttaaataag aacacccagt tgaatacaag 3302281 aaagaaaccg cacgccaatg tttgcagcac gtctctcttg ctccattttt cagttttata 3302341 ctggccggac gccagccagc aaaagcctaa aaacagcgtc gcgcaaaggc agcggacaaa 3302401 gaccaattca aatgacggca gattggtatg ctctgagaaa aagccgatgg agccgaaaat 3302461 caccatagag atgaccattt tgattacggc tgttgatttt tgttttgacg atatggaagg 3302521 atcctgttgc atcaaacgta ttctacctcc aatactgcat agcataaact gttttttgtg 3302581 aattcagaaa tctacacata gaattcctct tttttacatg tagatattat aacacttcta 3302641 ttctaaataa aaaaaagcgc ccaagggcgc tttttttaca aatctatcga acaatcaaaa 3302701 ccgggcatgt tgataattga gacactttat ggctgacgct tccaagcatc atttctttca 3302761 ggccgctgat cccccggctg ccaactacaa tcaggctgac gcctttctct tttgcgtgat 3302821 ttagtatctc atgcgccggc tcgccattcg cgtaaatggt ttcagcttga acgccttttt 3302881 cggctgcttt ttcttttgca ttctcaagga ttttcaggcc ctctttttta acctcgttcc 3302941 tgatttcatc aataaagtgt tcaggcacat agacaattcc cgtcagagaa gaagtcgtga 3303001 cgacggcttc tctccccaca tgaagaatgc ttagttccgc ttgttgctct tttgccaaat 3303061 gcactgcggc atcaagcgct tttgcactca tgtctgatcc gtcaatcgct actaacattt 3303121 tgttaaacat gctcttcccg cctttcggac tgtgggtggt tcatctttct cttttattgt 3303181 ccgcctgcat ttcgttattg tcaattgaag cgcatgagtt ttcaaaaaat tgtcagagac 3303241 tctctccgtt tgtggcgata acctgctgat accagttgaa gctttttttc ttgatgcggt 3303301 taaatgttcc atttccttca ttgtcccggt ctacataaat gaagccgtag cgctttttca 3303361 tttccgcagt agatgcgctg acaaggtcaa ttggccccca tgatgtgtat ccgattaatt 3303421 caacgccgtc cgcaatggct tcgcgcgctt caattaaatg atcacgcaga tagttgattc 3303481 tgtaatcgtc ctgaatcgtg ccgtcctctt caaccttgtc tacagcgcca aggccgtttt 3303541 caacgatgaa cagcggcttc tggtaacggt cgtataaggt gttgagcgtg atgcgcaagc 3303601 ctttcggatc aatctgccag ccccattctg atgatttgag gtaagggttt ttgactccgc 3303661 ccagcaggtt gccccctgat tttgcaagct cttccggatc tgtgctcgcc gccatcgaca 3303721 tgtagtagct aaatccaata taatccaccg tatgttcttt caagagctct tcatcgcctt 3303781 cagccatttc aatttcaata ttgttttctg ccagatagcg tttcatatat cccgggtatg 3303841 cgcctcttgc ctgaacatct gagaagaaaa gtgttttgcg ctcattctcc attgccgcga 3303901 agacatcctc cggcttagaa gtcatcggat aggttgtcgt tgccgctatc atacagccga 3303961 ttttcgaatc aggaatgatg tcgtgacccg ctttgacagc aagagcactg gccacaaatt 3304021 ggtggtgtgc cgcctggtac atcgcgttta atttgttttc tccttcttca aaaacaagac 3304081 cgcctccggt aaatggcgca tggagcacta cgttaatttc attaaacgtc atccaatact 3304141 tcactttgtg ttgatagcgt ttgaaaaccg ttttggcata gcgttcataa aactctatga 3304201 ctttgcgatt cttccagccg ccataatttt tcactaaacc gagcggcatc tcataatgag 3304261 agatggttac gacaggctca atatgatgct ttaacagctc atcaaacaga tcatcataaa 3304321 atctgaggcc ttcttcattg ggctcctctt catcgccatt cggaaaaatt ctcgtccacg 3304381 caatcgatgt gcggaacgcc ttaaatccca tttctgcaaa taaggcgata tcctctttat 3304441 aacgatgata aaagtcaatc ccgttgtgat acagattcaa ggaagtcatt gattcatcaa 3304501 atggagacat gatcccgttc ggcgatacgt cagctgtcga aagcccctta ccaccctcgt 3304561 tataagcacc ctccacttgg ttggcagcaa ctgcgccgcc ccataaaaat ccttctggaa 3304621 atcgtttttc atttgaactc atattgatca ccccattagt tttttcaaga taaagcaagc 3304681 agcgcttctt ttggctgcac tttaccgatc tctttcaccg gcgaaaacga atattggtct 3304741 gtgttggtca caatcaccgg ggtaatgacg tcatatcccg cggctttgat ttgctccaga 3304801 tcaaaggaca cgagcggatc tcccggtgcg accttgtcgc cttctttgat gtgagccgtg 3304861 aaccattgtc cctccagctt taccgtgtcc aatccaatgt gtatgagtat ttcagctccc 3304921 tgatcactcg taatgccaat tgcgtgtttt gttttaaaaa tggtggtaac gcttccacga 3304981 acaggcgaaa caacttctcc ttcttcaggc tcaatggcaa atccttttcc catgacccca 3305041 gcagaaaaca ctccgtcttt gacttcactt aaggctttca cttctccctt aatcgggctg 3305101 tgaatgatct ctctgctgcc ttcatgcact gccggctgct ggctgccgtc agaaggcaca 3305161 tcctcgaatc caagcaaata cgcagctgct gttcccgccg caaacgcaat cacaaggccg 3305221 atcatcgcgt aaataaacgt tgggccgata aagacaggga tgctcggcag acctgcattc 3305281 cccccgacga tataggaagc aacacccgtc atgccgtaaa acgcgccacc ggctgcaccg 3305341 ccaatcaaag cggccgcaaa cggctttttc aatcgcatat tcacgccgta catcgcaggt 3305401 tctgtgatcc ccatcagcgc cgtgatgctt gtggtaagcg cgagtgattt aaattttttg 3305461 tttctagagc gaaggaagac ggcaaatgat gctcccgcct gccccatatt cgccaaaaac 3305521 atagccggca gtaaataatc gtggccgttt tgagcgatgt tgttgatcat gatcggcaca 3305581 aaggcatagt gcatgcccgt cataatgatt aaagagaatg tacccgccag caaaatcatt 3305641 gccacaagcc ctgcatgatc aaacaaataa ttgaccccag aagacaagta ttctcctaaa 3305701 atagcgccaa gcggaccgac tgtaatcaat gtcagcggca cgacaatcaa tagcgtgaat 3305761 gtcggaacca caatcaattt gagagatgcg tgtgtaaaac ggtcaatcca tttttccacg 3305821 tatgaagcaa tccaaatcga cagcaaaatc gggatgaccg ttgacgaata agtggcagcg 3305881 gttacaggaa gcccgataaa ggaaatcggt ttccccgcac cgagcagggc tgtcaaatcc 3305941 ggatgcagga tcgccgccgc aatggcagcc gctacgtacg gattgcttcc gaattttctc 3306001 gccgcactca tcgctagcag gagcggcagg aagtagaacg caccgtcacc gacagccgtc 3306061 aaaatgacat gaacctggct cttctccgcc atccagccaa acgtgactgc cagcgccaca 3306121 agtcctttga tcatccccgc tcccgcaatc gcaggcagaa taggggtaaa caccccagaa 3306181 atcacatcaa agaccgcact cagcacattc tttttctgag aggatgaacc agcgctcttt 3306241 tcatcactga gattgctgtg ccgcacaatc gcctgataca ccttcggcac atcgtttccg 3306301 ataatgattt gaaactgctc gccgctgata ttggtgccca tcactccagg cagctgctcc 3306361 agctgactgc gatccgcctt cgcgttgtca tgaagattaa aacgcagcct cgtcatgcag 3306421 tggatcacgc gctgaacgtt ttcttcaccg cctacgagtt gtaatatgtc cttcgataat 3306481 ttatcataat ccatgtgtat acctcctttt tatgggggga ctgctggatg aaaggtggcc 3306541 gcctttcacc agcttttttt gtatcaaatg ctgcatcacc tcctaaaaga gaataaaaaa 3306601 acctaaatga cacagattgc gagagtctcc tcctgcacct gcaccattta ggttttgcct 3306661 gctttcgcag taacaatcct gacgggtcgt tttatttgtt tgtaggtata ctttagcact 3306721 agattcgtga gatgtcaacg ctttcatttt tggtgttgac tatcgtttct agaacaaaag 3306781 taatcataaa gatttgaact tagtattaac ttcaataaaa aattattgta attaaaaacc 3306841 ttgaaaggca ttttttccaa tcaaggttat gaatcgttac cgtttaaatt tttttaaaga 3306901 cttctttatc tgtactatta cattctttag ccaatctatt ggttctaaat taaacgcagg 3306961 aagatacacg ccatctgcgc aagattgaat gtaatcgttt ttcttattgt ctgaatgctc 3307021 actttcaata aaatccgtta aaaagacaat agcatcctcc aaatattcct tactttcctc 3307081 tattaataac tcttgtatag cgtcatcagg agtttcaata tcttgatgga atgttccagc 3307141 taaaaactga aaaacagggt ccttctgttt attgatcaat aacatgtcat cttgctcctt 3307201 taagggagag gtaacgggat aatgttaaaa tcattcatca tctaataaat caagataata 3307261 ctgatcattc tcttctattt ttcttaagaa ctcggtaaga gaagttgcaa tttgaatatc 3307321 ataatagtaa atcggatttt tattattatc atttaattca attgacatta atgccgattc 3307381 actaccttca aaaaatatta atttatcatt ctcaaactca tcatatattt ctatgtcagg 3307441 ataaaattca aagtcattta tcctcaatcg aaagtctctt acagaatatg gatccaaaat 3307501 gcgattagta ttaaactctg atcctttaat aaacccatag ccaacttcta aataaaaatt 3307561 cactaattca ctaggtaatt ttaagtttaa atttttttca acctcttcaa tctcactttg 3307621 attcactgga taaaaatcat tttctttgtt tgattttata aaattataac tcattttttt 3307681 ttgcctcctt taaataattc atttgctggt gagcctgtac catgaatccc agcttgatgc 3307741 tcgttaggaa attttgctgg atgcatattc caccattcat gttctccgcc aaaagtattt 3307801 tcaattatat ggtgagcatc atacttatcc cctttttttc taataatttt acctgttttt 3307861 tcagatacaa cattttcctt ataaacaggc catttttgtc cagtgttttc ttcccattct 3307921 tttataactt tattttttac tttatcaaat ttagtcctgt gttttgcagt ctctattggt 3307981 gacatttttt tatattcttt atttcttaat gcttccttta atttatctat ttgattttta 3308041 ggtaattctc tacctgtgcg ttgttctata tctctagcat acttttttat taaatcagaa 3308101 ttaattttat tagcagatcc acttacatca ttcgcaattt tccctttatc cttagcaacg 3308161 tttttaactt ccgaagcctt cttagccttt ttcccattat taataagttt attaatatct 3308221 attaactttt ctaacttagc tattttggca aatggtactg agtttatgga ggcaacaaca 3308281 cggtctttcc ctgtgacttt ttcgcctgat accggatctc tgcccgtggc tgctttaaat 3308341 agatcataca cgccggtaag ttctacagcc gtctctaaaa ttttcacata tccattctca 3308401 tccactttaa tgtccgaaag cgagacgaca ggttcaagct tcatgtcatt accagatatg 3308461 tatacattgt aaagtgtatc attataaacg acttgcttaa cctctgcatt tgagaaatca 3308521 gtttttatat gttctctatg ttcactcgta ttatacactt taccattgat aacgatgata 3308581 tttttactta cctttttaga atcacccgtt ttgacaactg aatccacttt agacttttca 3308641 ttctcggcta atttcttcag catcatctcc atcggtgaat catccgcctg cttcatttgc 3308701 gggttaatcg cgccgaagat ttggttgatg ttttcttctt cctgtgattt caggatggag 3308761 ccgcttttgt agcctgtgat ttcaattttc gggccggtgt acatggtttc gagctgatca 3308821 atgtattttt tcatcgtttg aaaatctgat tttgcggctt ctagtgcttg ggtttgctgg 3308881 ccgtcaaatt gaaagagctt attcagggtg tctgaaatca gccgctcagc ctgttctgtt 3308941 tccatccgaa aaaaggaatc attgactgtc ggcaggctga cgatgtgatc tatggctgat 3309001 gtctggcgat tgactgcgtc agtgagctgc tctgtcactt ctcgtgcatg cttgacccca 3309061 tgtctcgcat cgtgtgagag aaaagcctct gcgatcatgc cgtgggagtt agattctaca 3309121 gaggaaatcg catgctgtgt ttgtttcagc acttttttgt attcgtcgat aaatatgcca 3309181 aagaaaagga gaaaaggctt gtggcactcc tcgtaaaagg tccggatggc atctccgcct 3309241 tttcctttca gcgcatcctt catgcctgcc agatgctcaa cgcttttttc cagcttctcc 3309301 agctgttgtt tttgcttgtc cagtttctca atcgtatgct gaatgccctc gtgaagagcg 3309361 tggacatcta atgttttcaa tcccttgtcc tcccgcgctt tatttcatgg aagatgatat 3309421 gttttcgtcc gtttccttca tggcgtttac cgcgctttcc gtttgtgcga tatgcttggc 3309481 cagaacagac gcatatgctt cagtgagctc tttgatgtcc ttatttaatt gctcgatgga 3309541 cttcacaaca ttcaaatggt ttctgcctga gagatgaccg ggcaatgagg acttgagttc 3309601 agctgaattc ttgagctgag aaagcccttg cttcactgtg tcatacacca ttttaatttc 3309661 ctgtgccatt tgtgctcacc tcacttttta tgtttttcct tctctatttc atgctctatc 3309721 ctcgtgattt ggcgtcttat agaatacaca tcgccctcta atgagtggat ttttccttct 3309781 atgctttcga tgattccgct gacttgatcg cttttgattt gctgatatgc tttgttcatt 3309841 ccttcacgaa tatcttcaaa ccgctcagca tgtgttcctc tccatgcctc ccggttaaga 3309901 tgaggccggt gaatgagatg ctgggcctca gagaaatcgt gtttgatttg cctaatttcg 3309961 tgcagcactc gttttaattg atggatctgt tcctgctttt catgtaagtc ggcttttacc 3310021 gaatgtaaca acatttcact atgcatgccg caacacctcg tgtttctatc aaactgtgta 3310081 aattctttac aatacagact attttcatat tacatgatgg gtcatattgg ataaataggt 3310141 aaaaaggatt gtcttgagag gtatagaact ggttctaaat tgctaaaaat acgatctcat 3310201 caccctatga aaggagaaaa caatcatagt agggactttt tatttaagcc tttaatctct 3310261 cctccagttc taatttttcc tcccacttaa ctgtttctta tagtcaataa agctcataaa 3310321 aaaacacctt ccctcgaagg cgcttctcca tcttatttag atccccatac agcctcaccg 3310381 ctggtattca gcacactaaa cgtcatgacg ttcttctctc tcaccgaatc ccactggcgt 3310441 aaaaataccc cgttatactt cttgcctgct aacgtgatgt cggcggtgtt ttttccggtt 3310501 ttcctccatg ttccggtcat ttccccggaa atggtgtggt ttttgttgag ctggatgttg 3310561 atggtttgtt tgatgtcggc tgagatgtct tttccgtgct ggataagttt gtatgttcct 3310621 gtgatgtctt tttgttttac ttctttcaat gtttcgcccg cataacgata tggtgctgct 3310681 accggccagc cgtctttgtt catgaacaat tggtggactc tgacttcgtg ttcttcaccc 3310741 ctgcccggga agcgggtgtg gaagattaaa taggaacgcc cggttttttc atcatagtat 3310801 gcggagttgt ggcctggtga gacgtacccg gtgccttttt cattttctgt ttcaaaagtg 3310861 tagctgccca tgagtttgac gccgtatggt tcgatggaac ggtcgtcgaa gaatgtgcct 3310921 cccttgccgc ggacgtcgag cattggattg ccttctgcat catagtaagg gccgtccggt 3310981 ttcttggagc gggccacacg gatgttgtag ccgcctgttg catcgagacc gccatatgat 3311041 aggtataagt agtagtattg ggtgtctgga ttgtagagaa catacgggcc ttcgattctg 3311101 ctgtggttgc cgccgagcag ttttttccca tatccctgtc caggaagcgg gaagcccgtt 3311161 ttcggattca tttcaagtat gaaaatgccg cctgagtatg atccgtacac catccacagc 3311221 ttgccgtctt tatcaaagaa ggtatgcggg tcgacgacat tcggatgttt ggttgcatca 3311281 tacggtgttc catcgctgct tgtgccttcc attcctgatt tcaaaaagat gcctttgttt 3311341 ttgtatgggc cttcgatgtt gtcagcaacg gcaacaccca tggcggatct tggcgaatcg 3311401 ccgcggcagg cgttgtagta catgtagtat ttgccgtccg ccagctgcgt gacgtcagcc 3311461 gcccaaagag tatcggattg cgcccattcg aaggtttctt ttaattcttc atagacattc 3311521 gggataagtg ggttgtcatt gcttacgctg gtggtcagct gctgccattg catgaggtca 3311581 ttcgatttag ctgaagcgag atgagatcca aaaacataaa aagtgccgtt tgtttcaatg 3311641 atggaagggt catggacgct gacttcttta aatataggtt tttgtgcata gacggagttt 3311701 gggagggtga aggccatgat aagagctgca agaaaacata cacggaacaa tcggttgaac 3311761 atctaaacaa ttcgcctctc ttttttatta aattttaaac gcttacattt ctctatgaag 3311821 ataccccggc ctattaaaac agccgaatgt tttcatattc atccagatag gtgatttctc 3311881 acttcactta catagtcaga ctgatgtctg tctgttttgc gcagaacttg ttgcttgcat 3311941 atcctctcct tcatagttca actcttttgc tgtttctcct tcttgcatca cgtctgtttt 3312001 tctttcgcgt acatgtaata actgctttgt caggttttgc atcaactgtg atacagccat 3312061 ttcgttgtcg gcgtttttta agatgatgcc tgattgcccg tcaacaccag agtcattcgg 3312121 ctggctcttt ataaaacgcc ttgcgaaaaa tacgacttag taaacgcata ttgagagtta 3312181 gacagcggcg cttgcctcct tgtctggata tcgtgtgcaa tcgctgaaaa aacctgttct 3312241 gctttctgcg tcacgctatt acaatagcaa tctaacttgt taaagactat aaaaaaacct 3312301 tttgacttct gctgctgaac caattaatat aatactcagt taatagttat cagaattttt 3312361 aggaattgag tgattcatat gacactgcat aaagagcgtc ggatcggccg gctgtctgtt 3312421 ctcctgctgc tgaatgaggc ggaagaaagt acgcaggttg aggagctgga gcgagacgga 3312481 tggaaggtct gtcttggcaa ggtaggatca atggacgcac ataaagtagt agccgcaatt 3312541 gaaaccgctt ccaaaaagag cggtgtcatt caatctgagg gttatcggga gtcacatgcg 3312601 ctttatcatg cgacgatgga ggctttgcat ggcgtgacca gaggtgaaat gctgctggga 3312661 tcgctgcttc ggacggtggg attgaggttt gccgttttga ggggaaatcc ttatgaaagt 3312721 gaagcggaag gcgattggat cgctgtctcg ctttacggaa caatcggggc gccgattaaa 3312781 ggtcttgagc atgaaacatt cggcgttgga attaatcaca tatgaaacag cccatagatc 3312841 ttagacgata gggggctatg cgtgaaaaca gaagttcaca gcatagctcc tttttgtatg 3312901 ggcgctttac caaagtaaag aaaaaggagt tgggcttatg gtgactttag acggttcttc 3312961 attgacaaca gccgacgtcg ctcgtgtgct gtttgatttt gaggaggcag cggcttctga 3313021 ggaaagtatg gagcgcgtga aaaaaagcag agcagcagtg gaacggattg tacgcgacga 3313081 aaagacaatc tacggcatca acaccggatt tggcaaattc agcgatgtcc tgattcagaa 3313141 agaagactcg gcggcgctgc agctgaattt aatcctttct catgcctgcg gagtcggcga 3313201 cccttttcct gagtgtgttt ccagggcaat gctgcttttg cgcgccaatg cgctgttaaa 3313261 aggcttttcc ggtgtacgcg ctgagctgat cgagcagttg cttgcttttt taaataaacg 3313321 cgtccatcct gtcatccctc agcaaggatc acttggcgca agcggagatc tggcgccgct 3313381 ttcccacttg gcgcttgcgc tgatcggaca aggagaagtc ttttttgagg gggaaagaat 3313441 gccggcaatg acaggcttga aaaaagcagg tattcaaccg gtaacgctga catccaagga 3313501 agggcttgcc ttgattaacg ggactcaggc catgactgca atgggggtgg tcgcctacat 3313561 cgaagctgag aaactagcct atcaaacaga acgaattgcc agcttaacga ttgaggggtt 3313621 gcagggaatt atcgatgcat ttgacgagga tattcactta gcccgcggct atcaggagca 3313681 gatcgatgtc gcagaacgaa ttcgctttta tctatctgac agcggcctga caacctccca 3313741 gggagaactg cgggtacagg atgcctattc attgcgctgt attccgcaag tacacggtgc 3313801 gacttggcag acactaggat atgtcaaaga aaaattagag attgaaatga acgcagctac 3313861 agacaatcca ctcattttca atgacggtga caaagtgatt tccggcggaa actttcacgg 3313921 acagccaatc gcctttgcca tggattttct gaaaatcgca atatcagagc ttgcgaatat 3313981 cgcagagcgt aggatcgaac gacttgtgaa tccgcagctg aatgacctgc cgccgttcct 3314041 gagccctcat cccggtctgc aatccggtgc aatgatcatg cagtacgccg cggcctcact 3314101 cgtttctgaa aataaaacac tggcccatcc tgcaagtgtg gattccattc cgtcatccgc 3314161 caaccaagag gaccatgtca gcatgggaac catcgccgct cggcatgctt atcaggtgat 3314221 cgcaaataca aggagagtca ttgcgatcga agccatttgc gcattgcagg ctgttgaata 3314281 cagaggcata gaacatgcag cgtcctatac gaaacagctt tttcaagaaa tgagaaaagt 3314341 cgtgccgtcc attcagcagg accgtgtttt ttcctatgac attgaacgct tgactgactg 3314401 gctgaagaaa gaatctttaa tacctgatca tcagaataaa gaactaaggg ggatgaacat 3314461 atgactgatg taaaaaaatc aatccgtgcc aacagaggaa cagagcttga atgcttagga 3314521 tgggagcaag aggcagtgct tcggatgctt cgaaacaacc ttgatccaga agtcgccgag 3314581 aagccggagg acctcatcgt atatggcggg attggcaaag ccgcacggga ttgggacgct 3314641 tttcacgcca ttgagcattc cttgaaaaca ttaaaaaatg atgaaacatt gctcgtgcaa 3314701 tccggaaagc ccgttggcat gttccgtaca cacccgcagg cccctcgcgt gctcctagca 3314761 aattctgttc ttgttccgaa gtgggcagac tgggagcatt tccacgaact tgagaaaaaa 3314821 gggttaatga tgtacggaca gatgacggct ggcagctgga tttacattgg ctcacaaggc 3314881 atattgcaag gaacctatga aaccttcgct gagctggcgc gacagcactt cgggggcagc 3314941 ttaaaaggaa cgttgacgct gacagcgggt ctcggcggaa tgggaggcgc ccagccgctg 3315001 tcagtcacga tgaatgaagg cgtcgtgatt gccgtcgagg ttgacgagaa acgcatcgac 3315061 aagcggatcg aaacaaaata ctgcgatcga aaaacagcat cgattgagga agccttagct 3315121 tgggctgaag aggcaaagct ggcaggaaaa cctttgtcca ttgcacttct cggaaacgca 3315181 gctgaggtgc atcacacact tttgaaccga ggcgtcaaaa ttgatattgt gacagatcag 3315241 acatctgccc atgacccttt aatcggttat gttcccgagg gctattccct tgatgaagct 3315301 gaccgtttgc gtcaagacac tccagagctt tacgtgcgcc ttgcgaagca aagcatgaaa 3315361 aaacatgtcg aagccatgct ggcctttcag caaaagggct ctattgtatt tgactacggc 3315421 aacaatatcc ggcaagtcgc aaaggatgaa gggctggaga atgccttcga ttttccgggg 3315481 tttgtccctg cctacatccg ccccttattc tgtgaaggaa aagggccgtt ccgctgggcg 3315541 gcgctttccg gagatccggc agatatttac cgtacggatg cgttattaaa agagctgttc 3315601 ccgacaaata aagcccttca ccgctggatt gatatggcac aggaaaaagt caccttccaa 3315661 ggcttgccgt cccgtatctg ctggcttgga tatggagaac gaaaaaagat gggcctcgcc 3315721 attaacgagc tggttagaac cggggagcta aaagcgcctg tcgttattgg gagagatcat 3315781 ttggactgcg ggtctgtcgc ctctccaaac cgggaaacag aagcgatgaa ggatggaagt 3315841 gacgctgtcg gtgattgggc tgtgctaaat gcgcttgtca acacggcggc gggtgcaagc 3315901 tgggtttcct tccaccatgg cggcggcgtc ggaatgggct attcccttca tgccggcatg 3315961 gttgcagtgg ccgatggaag tgagctggct gacgagcggc tcgcgcgggt cttaacgagc 3316021 gacccaggaa tgggcattat ccgtcatgcg gatgcgggtt atgaacgtgc cgttgaagta 3316081 gcgaaggaac aggacattat cgtgccgatg caaaaataaa ggagtgatga catgccaaag 3316141 caaattgata cgattctcat caacatcggt cagcttttga cgatggaaag cagcggtccg 3316201 cgggcaggca aaagcatgca ggatcttcat gtgatcgaag acgctgttgt cggcatccat 3316261 gaacagaaaa ttgtgttcgc cggacaaaaa ggggctgaag ccggttacga ggcagacgaa 3316321 atcattgact gttcgggacg ccttgtaacg cctggcctcg ttgatccgca cacccatctt 3316381 gtatttggcg gatctcgtga aaaggagatg aaccttaagc ttcagggcat ttcatatttg 3316441 gatattctgg cgcagggcgg cgggattctg tctacagtca aggataccag ggcggcttca 3316501 gaagaagagc tgctgcaaaa agcccatttt catctgcaaa gaatgctgtc ctacggcaca 3316561 accacagcag aagtgaaaag cggctacggc ttggaaaaag agacagagct caaacagttg 3316621 cgtgtcgcaa agaaactgca tgaaagccag cctgttgacc ttgtttccac atttatggga 3316681 gcccatgcga ttcctcccga atatcaaaac gatccagatg attttctgga tcaaatgctt 3316741 tcccttttgc cggaaatcaa agagcaggag ctcgccagct ttgctgatat ttttacagaa 3316801 acaggcgttt ttacagtcag ccaatcccgc cgttatttac aaaaagcagc tgaggcaggc 3316861 ttcggattaa aaatacacgc agatgaaatc gatccgcttg gaggtgctga attagcaggt 3316921 aagctaaagg ccgtctcagc cgaccatttg gtaggtacat cggacgaagg cataaagaaa 3316981 ttggctgagg caggaacgat cgccgtcctc ttgccgggca cgacatttta tcttggcaaa 3317041 agcacatacg ccagggcaag agctatgatt gatgaaggtg tatgtgtcag cttggcaacg 3317101 gattttaatc ctggcagctc gccgactgaa aatatccagc tgattatgtc cattgccgcg 3317161 cttcatctga aaatgactgc agaagaaata tggcacgcgg tcacagtcaa tgccgcatat 3317221 gccataggaa aaggagaaga agccggtcag ctcaaagctg gccgctcagc tgatcttgtc 3317281 atttggcaag ccccgaacta tatgtatatt ccgtatcact acggggtcaa tcatgtacat 3317341 caagtcatga aaaatggaac aattgttgtc aacagggagg gagccattct tggataagta 3317401 cccttttctc agagaggccg gatcttcgtt taaagaccgg gatgtcacaa aaatgagcga 3317461 cctgatcgca acatgggacg gccaggacat taagggaccg gcgttgatag gtgtccccct 3317521 atcaaaatcc tccatcagtc attcaggcgc ttcctttgca cccggaacaa tacgccaggc 3317581 tctgaaacat tcatcagcct attctgctga gcttggagag cacgtcgtat cagagcttct 3317641 atatgacctg ggggatatcg atattcatgt cactgatatc gtaaagtcac atcatcacat 3317701 tttccaaacc atgcacgctc tgctttcgga tcatccggat tgggtgccgc tcatacttgg 3317761 gggagataac tctatcagct actccacaat aaaagcgata gcacaaacaa aaggaacgac 3317821 agcggtgatt caatttgatg cccatcacga tgttcgcaat acggaggacg gggggccgac 3317881 aaacggcacc cccttccgcc gccttttgga tgaagagatc attgaaggtc aacatttgat 3317941 ccagctgggt atcagagaat tcagcaacag ccaggcctat gaagcatatg caaaaaaaca 3318001 taacgtgaac attcacacga tggacatgat ccgggaaaaa ggactaatcc caacgataaa 3318061 agagattttg cctgttgttc aagataaaac agatttcatt tttatatctg ttgacatgga 3318121 tgtcttagac cagtcccatg cacccggctg tccagcgatt ggcccgggcg gcctctatac 3318181 agacgaattg cttgaagcag tcaagtacat cgcacaacag cccaatgttg ccgggattga 3318241 aattgttgaa gtcgacccta ccctcgattt tcgagatatg acaagcagag ctgcagctca 3318301 tgttctgtta cacgcattaa aaggaatgaa actctcccca ttcaagtgat cttctggcag 3318361 gttgtatttt gggtataaga aactcatctg cctaaggaat ggcagctaaa aggagggcga 3318421 gacagtgaat cttcaggaga acagcagcca acagctaaaa cgcacaatga aaagcaggca 3318481 cctatttatg atctcattgg gaggcgtcat aggcacagga cttttcctca gtacgggcta 3318541 tacgctacat caagccggac ccggcggtac gatactcgct tatgtaatcg gcgggttgat 3318601 gatgtacctc gtcatgcaat gtctcggcga attgtcggtt gccatgccgg tgaccggctc 3318661 ttttcaaaaa tatgctacaa catttatcgg tccatctacc ggttttatgg tcggcatcat 3318721 gtactggatc aattgggtgg tgacggtagg ctctgagttt accgcatccg gtattctcat 3318781 gcagcgctgg ttccctgaca gcagtgtatg gatgtggagt gcgatttttg cagcccttct 3318841 ttttatatgc aacgcatttt cagttaagtt atttgcggaa actgaatttt ggttttccag 3318901 cgtaaagatt gtcaccatta ttttatttat cattttagga ggagccgcca tgtttggcct 3318961 gatctcttta aacggaacgg cggatgctcc tatgttgtca aacttcacag atcatggcgg 3319021 gttgtttcca aatggctttc tcgccgtttt tatcgcgatg atatctgtga gcttcgcctt 3319081 ttccggtaca gagttaatcg gcgttacagc aggagaatca gcaaatcctc aaaaggatat 3319141 accgcgatcc atccgtaatg tcgcatggag aaccgtgatt tttttcattg gcgctgtctt 3319201 catattatcc gggttgattt catggaagga cgcaggcgtg attgaaagcc cgtttgtcgc 3319261 cgtatttgcg gagatcggaa ttccttacgc tgctgatatt atgaatttcg taatattaac 3319321 agccttgctg tctgtcgcca actcaggctt atatgcttcg acccgtatga tgtggtcttt 3319381 agcaaatgaa aacatgatca gctcccgttt taagaaagtg acatctaaag gcattccttt 3319441 aaatgcctta atgatcagta tggctgtatc ttgtttatct ctcgtttcca gtatcgtggc 3319501 ccctggaact gtctatgtgg tgatggtcgc aattgctgga tttgcaggag tcgtggtctg 3319561 gatgagcatt gccttgtccc aactcttgtt tcgaaagaga tttttgaaaa aaggggggga 3319621 tgtaaaagat ctgacatttc gcacgccgct ttatcctctt atgcctatag ccgctctctt 3319681 attatgttct gcttcttgta tcggtcttgc ttttgatccc aatcaaagaa tcgcactttt 3319741 ctgcggagtt ccttgtatca tcctttgcta tctcatctac catttcaaaa gaaatgttac 3319801 aaaagcgaaa aaaatcagcc aagaggaata tccagccgat cacatcctat aattaaaaaa 3319861 gcacaccccg ctcagcatgg gatgtgcttt attttttatt ctgtaattaa cgtatgaatc 3319921 agcttcggcg ccttcgcttc cgcggcgatg cggatgttgt catagacttt tgcgatgact 3319981 tcatcgacgt tttctcggtt agcgtaaagc gttacgagcg gttccccttt ttctactttg 3320041 tcgccgacct ttttgcggag catgatgccg acggctaaat cgatttcgtc ttcttttgtg 3320101 gcgcggccgg cacctaacag catcgccgcg acgccgattt cgtccgcgac gatttcagag 3320161 acgacacccg cttctttggc aggcacatca atttgatatg cggcttgcgg aagcttagac 3320221 ggatcgtcaa caattgagct gtcgccgcct tggtttttca ggaaatcctt gaatttctca 3320281 agtgctttgc cgtttttcat gacttcttcc agcttcgctc tcgcttcgtc caatgtatcg 3320341 gcttttttcg caagcacaac catctggctg ccgagcgtta agacaagctc atgaagatcc 3320401 tcaggcccct cgcctttgag cgtgtcgatc gcttctttga cttcaagcgc atttccgatc 3320461 gcaaagccga gtggctggga catgtctgaa atgacagcca ttgtttgacg gccgacgtta 3320521 tttccgatgc gtaccatcgc tttggcaagt tcagctgcgt cttcttctgt tttcatgaag 3320581 gcgcccgctc ccgtttttac gtcaagcacg atggcgtccg ccccggcagc gatttttttg 3320641 ctcataatcg agcttgcaat gagcggaatg gaattgaccg ttcccgttac atcacgaagc 3320701 gcgtacagtt ttttatcagc cggcgttaaa ttgccgcttt ggccgatgac cgcaaccttg 3320761 tcgcggttca caagtttaat aaattcatcc ttcgtcagtt ccacgtggaa gcccatgatt 3320821 gcctctaact tatcaatcgt gccgcccgta tggccgaggc cgcggccgga catcttagca 3320881 accggcacat caagagccgc aacaagcgga gcgagaacga gcgttgtcgt gtcgccgacg 3320941 ccgccggtag agtgtttatc cactttaatt ccttcaatgg cagaaagatc aatcgtttca 3321001 ccggagttca ccatagccat cgtcaagtcc gcgcgttcac ggtcactcat atcctggaag 3321061 aaaatcgcca tagcaagcgc gcttgcctga taatcaggaa tgcttccatc tgtatagccg 3321121 ttcacaaaaa attgaatttc ttcagtggtg agttcttttc cgttttgttt tttgatgatg 3321181 atatctacca ttctcatgtt tggtcaccga tccttttcga ttaagttcag taaatcaagc 3321241 ccacaattgc tgctgataaa aagctgacaa gcgtagcacc gtataataat ttcaagccga 3321301 aacgagcgac gacatttcct tgcttttcat tcagtccttt tacggcaccg gcaatgattc 3321361 cgattgagga gaagttcgca aatgacacaa ggaataccga tacgatcgct gttgtacggc 3321421 cgctgaaatg gaaaccgttt tgcgtaagcg acgtcatggc gacaaattca ttcgatacca 3321481 tttttgttgc cataatgctt cccgcattaa cagcttcatt ccatgggata ccgacaagaa 3321541 aagcgaatgg agcaaacaca tatccaagaa tgccttggaa cgaaataccg aatactgcat 3321601 taaaaatgcc attgatcaat gcaataatcg cgacaaatcc aatcagcatc gcagcgacga 3321661 caaccgctac tttgaaaccg tcaagaatgt attctccgag cacttcgaag aaggattgtt 3321721 tttcttcttc ctcaacacga agcatatcct cttcttttgc aacctcgtac ggattgataa 3321781 tagaagcgat aatgaaaccg ccaaataagt tcaaaacaag cgctgttaca acatattccg 3321841 gtttcagcat tgtcatatac gcaccgacaa tcgacattga tacagttgac atcgcagatg 3321901 cgcaaagcgt gtacaagcgc tgctgattta aaagaccgag ttctttcttc aaggagataa 3321961 atacttctga ctgccctaaa atcgcagaag ccactgcgtt atacgattcc aatcttccca 3322021 taccgtttac cttgctgagg gcaaggccga tatatctaat gataaacggg aggactttcc 3322081 acttttgcag aatcccgatc agagcggaaa taaacacgat tggcaagaga acattcataa 3322141 agaatgtcgt ttggtccgca ttcaccaagc cgccaaacac aaagttaatt ccctctgccg 3322201 cgtattcaag caggtaaccg aatccttttg caaatcctcc cacgaggaaa ttccctattc 3322261 cggtattgag gagaatgtag ccaagaataa attgcaaaat gagcataaca acaattgggc 3322321 ggatcttaat tctttttttg ccgctgctcg cgatccacgc gaggcctaaa aacacgatta 3322381 aaccgataat cccaatcaaa tacttcatat gtgtttctcc tttatttgta ttcgcttaca 3322441 attactgttt cctcagaaaa cggaaagcag tctgccttcc gtcagctctt aatagttgtc 3322501 tccgcctgat gcattttctc cttttacgat agaaacgcct gcgctggcgc caattcggct 3322561 tgctccggcc tctaccattg tgtctacatc ttctttcgtt ctgacgccgc cagatgcttt 3322621 cacgccgata tcaggcccta ctgttttgcg cattaaggcg atatcttcct tcgttgcgcc 3322681 gcctgtagaa aagcctgttg atgtttttac gaaatccgct cccgcagaca ccgctaaacg 3322741 gcatgcacgt tctttttctt catcagtcag aaggcacgtt tcgataatga ctttgacaag 3322801 cgcttttccg gctacagctt ccactacacc gcggatatca gcttccacca catcgtcttc 3322861 cttgtctttt aaagcggcaa tattaatgac catatccact tcagtggcgc cttttgaaat 3322921 ggcgtctttt gtttcgaacg cttttgtttc agttgtattg gcaccgagcg ggaagccgat 3322981 gaccgtacaa acgtcgactc cagttccctt aagctctttt gcagcaagct ccacccatgt 3323041 cggattgaca catactgaag caaatttgta tgttttcgct tcttcaatta gttttagaat 3323101 gtccgctttt tgtgtatgcg gtttcaaagc tgtatgatca attatgttgg ctaatgacat 3323161 ccttcgcaca cttccttttt tgttaagata ttttttagca taaccgactt ttgaacatat 3323221 gtaaattggt aattgaaatt ttgttcaatg aaaggtttga acgtgtcaca aatcattaac 3323281 aagcgccctc gcggtatgct ggtcaatgat taaaacgttg gcatattttc cggttaatgc 3323341 tccgtgaatg gaagatactt ttctgcttcc gccggcaact aaaatggagc gttccttcag 3323401 tctaaggtct tgaagctcaa caccgatggt ccggtcattg atggcgctgc tgcaaatatt 3323461 ccctttcgca tcaaaaaagc gtgaacaaat atccccgacg gcctgttttt tcagcagggc 3323521 tttctcttct tcgttaaaat atccgagccg aaacaacagc gcttcatcac ggacagtccc 3323581 gaccgtaaag agagcgatat tcgcctgctt gcccatctca atgatccgtt caatatgacg 3323641 gtctttctcc accattcgct tcacatccgc attatcaaac acgacgggaa gcgggagata 3323701 gcgcggcatc gtttgaaaag cctctgcaaa cagctgaatc gtttcagccg aatacgtgtt 3323761 tacccgggaa tggctgatgc cgcctttcag ctggacgacc tcgacgcctt ttacctgctt 3323821 cggctgcatg ttttgcgcga tttgatacat ggtggttccc cagctgacgc cgacaatgtc 3323881 gccgtctttt accgtttcat gcatatattc tgcaccatag cggcttaggt catgtgtaat 3323941 tcctgcataa tcgggtgtcg gggaaaacac aacatgcgcc tcaaggagcc cgtatttctc 3324001 ttcaagtatg gaaccgagcg catccaaatc ctcaaaaggg tccatgacgc gaatctggac 3324061 ataccctttt tcctttgcat attgcagcag ccgggaaacg gttggccttg aaatgttgag 3324121 ctgctcagca atttgctgct gactgtagtc agactgatag taaagccttg ccgcttctat 3324181 gcttaattgc tgtttttccc gatccattct gcacctccct gtggatcagt cctgataaaa 3324241 ctgcttttga tttgctttta ttatacaggc tggcgccggc tttcatccac ctgatttcta 3324301 agaaactgaa aaacgctctg ggcgcggacc tgcccagagc ttacttctcc caagtcggtt 3324361 tctctgagca taaagttatt tcgtttttcc taaactcagc ggatctgtga tcatctcttt 3324421 tggctataaa gtttccgttt tttcaaaaca aatgtttcaa atgagatagg aaatgggtac 3324481 taatctatta actttgttac atatttttag atactcattg gctcaacaac tgaggaggag 3324541 acatttgtga agaaagacac aaggaaatat atgatctact ttttcggcgc tttaggggga 3324601 ctgctatatg gttacgatac aggtgttatc tccggagcac tcctgtttat caataacgat 3324661 attcctttaa cgacattgac agaaggattg gttgtcagca tgctgctcct tggcgcgatt 3324721 ttcggttctg ccttgagcgg cacatgctca gaccgctggg gcaggagaaa ggttgtattt 3324781 gtcctttcca tcatttttat tatcggtgcg ctcgcttgcg cattttctca aacaatcggc 3324841 atgctgattg catctagggt gatactcggg ttggccgtcg gcggttcaac ggcacttgtg 3324901 cccgtgtatc tttccgaaat ggcaccgacg aaaattcgcg ggacactcgg cacaatgaac 3324961 aacttaatga ttgtcaccgg gattttgctc gcctatatcg ttaactacct gttcacaccg 3325021 tttgaagcgt ggcgctggat ggtcggtctg gctgcagtgc ctgccgtgct tctattaatc 3325081 ggcatcgcct tcatgccgga atcgccaaga tggctcgtga agcgcggcag cgaagaagaa 3325141 gcgagacgca tcatgaacat cactcatgac cccaaagaca tcgaaatgga attggcagag 3325201 atgaagcaag gggaagcgga gaaaaaagaa acgacacttg gcgtgctgaa agccaagtgg 3325261 attcgcccta tgcttctgat tggcgtcggc cttgccattt tccagcaggc agtcggcatt 3325321 aacacggtca tctactacgc gccaaccatt tttacgaagg ccggtcttgg cacatcagct 3325381 tcggcgctcg gcacaatggg aatcggcatc ctcaacgtca tcatgtgtat cactgccatg 3325441 atcttaattg accgtgtcgg ccgcaaaaaa cttctgatct ggggaagtgt cggcatcaca 3325501 ctgagccttg ctgctttatc aggcgtgctc ctgacactgg ggctttccgc atcaacagcg 3325561 tggatgacag tagtctttct cggtgtctat atcgtctttt accaggcgac atggggtccg 3325621 gtagtgtggg tgctcatgcc tgagctcttc ccgtccaaag cacgcggagc cgcgacaggg 3325681 ttcacgactt tggtgttatc ggcggctaac ctgatcgtgt cgcttgtctt cccgctgatg 3325741 ctaagcgcga tgggcatcgc atgggtcttt atggttttct cagtcatttg tcttctctca 3325801 tttttcttcg cgttctacat ggtaccggaa accaaaggga aaagcttgga ggaaattgaa 3325861 gcaagcctga aaaaacggtt taaaaagaag aaaagcaccc aaaaccaagt gctgaatgag 3325921 cgtacattat aaaaaaagga atcgtctcct tatgagacga ttcctttttc tgtttacacc 3325981 atgaccttgc aaatattgtt cgtaaattcc acagggtcct gaatcggcag gccttcgatg 3326041 aggagcgcct gattgtacag aaggtttgtg tacaggctca gcttctcttt atcttgttca 3326101 aacgcgtcct gcagtgtttg gaatacctcg tgatttgggt tgatttccag cactttttcc 3326161 gccttcacat tttggctgtc aggcatcgca tttaagattt tttccatctc aattgtcact 3326221 tcgccgtcag cagcaaggca gactggatgt gatttaagcc gttttgagat tctgacgttt 3326281 ttcactttgt ctgacagaat gtttttcatt tcctcaaaca gatccttata cttgctttcc 3326341 tcttcctcgg actgcttttg atcctcatcc gtgtctatgc caaggtctcc gcttgatacg 3326401 gacttgaatt ctttttcctg ataagaagcc agcattttaa ttgcaaactc atcgatgtcc 3326461 tcagtaaagt agaggatttc atagcctttg tccgccacca tttccgtttg cggcagtttc 3326521 tcaatgcggt cgtaagaatc accggtcgcg taataaatga atttctgctc ctctggcatt 3326581 ctggaaacat actcgtctaa gctgaccagt tttttctctt ttgaagagta gaataagagg 3326641 agatccttca attgatcctt attcgcgcca aaatcattgt acacgccgaa tttcagctgt 3326701 ctgccgaacg acttgtagaa cgtctcgtat ttctcgcggt cttttttcaa caggctttgc 3326761 agctcgcttt tgattttctt gctgatgttt ttcgcgatca gcttcagctg gcggtcatgc 3326821 tgcagcattt ctctggaaat attcagcgac agatcctcag aatcgaccat gcccttcaca 3326881 aagctgaagt ggtccggtag caggtctgcg cacttattca tgatcagcac gccattggaa 3326941 tacagctcca agcctttctc atattccttg gaatagtagt caaacggcat gttttcaggg 3327001 acgaatagaa tcgcgttgta gcgaaccgct ccatccacgc tgatatgaac gtgtgtcagc 3327061 ggtttatcaa acccgtaatg cttttcagca tagaattttt cataatcctc atctgtcagc 3327121 tcgcttttgt tttttctcca gatcggcacc atgctgttga ccgtctgctc ttcctgcacc 3327181 tcttcaaatt cattttcgct gccttccttc ggcttattaa tggttgtatc cattttgatc 3327241 gggtagcgaa tgaagtcgga gtacttcttg atgatcgctt ttaaacgata ttcctctaaa 3327301 aactcgtcat agctgtcatc ttctgtgttc tctttgattt tcaggataat gtctgtaccg 3327361 acagaatcct tttcacacgg ctcaatcgta tagccgtctg cacccgcaga ctcccattta 3327421 taagcctctt cgctgccaag cgctttactg atgactgtca cgacatcggc aaccataaat 3327481 gccgcgtaaa aaccgacacc gaactgcccg ataatgtcat gtccgtcttt cagctcgttt 3327541 tcctttttaa acgcgaggga accgcttttt gcaattgttc caagatgctg ttcaagctca 3327601 tcctttgtca ttccgatccc cgtatcagag atggttaatg ttctcgcatc tttgtcagct 3327661 gcgaccttta tgtagtaact gtctttatca aacgtaagcg catcgtccgt aagcgctttg 3327721 taatagattt tgtcaatcgc atcactcgaa ttggagatta actcgcgcag gaaaatttct 3327781 ttttgggtat aaatggagtt aatcatcata tccagcaagc gtttagactc tgctttaaac 3327841 tcttttttcg ccactcttga tcgctccttt accattatgt aaaccctttt cagcatctat 3327901 ttatcacata agatgacaat tgtcaattag attgatagat gcatatatat gtaaatttaa 3327961 cattagttgg atttgttttc actctttttc tcactcattc tcataaaaaa gagaggcttc 3328021 atcatcctct ctttttttct gtgtcattcc aacggccaaa ctcccgcttc atccatatat 3328081 gcaccgggta gaaaaacaaa ccgaacggta tcaaaaacaa aagattatgc catgaagcat 3328141 tcagaaatgc gcttgcagtc accgggaacg taatctcttg caataaaaaa gagatgacag 3328201 tcagcacaac aaatgcagat ggaatggtca cgatgcaata aaacttgagc tccttcttat 3328261 gctgtacctt caaacataca aacctcccaa caatttctaa ttcatcttaa catatgctgg 3328321 cctttctttt ctcgcatgtt tatcactgca catagcggga agacaaatag aaaaaggagg 3328381 tctcgtatca tgggaagact tgaaaacaaa acagcagtta tcacaggcgc cgcgacaggc 3328441 attggtcaag cgacggcgga ggtttttgcc aatgaaggcg cgcgtgtgat catcggagat 3328501 atcaataaag atcaaatgga agaaacagtt gacgcaatca gaaaaaacgg aggacaggcc 3328561 gaatcctttc acctcgatgt gtcagatgaa aacagtgtga aagcatttgc tgatcaaatc 3328621 aaggatgcat gcggaacgat tgatattctg tttaataatg ccggcgttga tcaggaaggc 3328681 ggaaaggtgc acgaatatcc ggttgacctg tttgaccgca ttatcgccgt cgacctgcgc 3328741 ggcacattcc tttgcagcaa atatttgatt ccgctcatgc tcgaaaatgg aggctccatc 3328801 atcaacacct cctccatgtc aggccgtgcc gcggaccttg accgctccgg ctacaacgcc 3328861 gcaaaaggcg gtatcaccaa cctgacaaag gcaatggcaa tcgactacgc acgaaacggc 3328921 atccgcgtca attccatttc accgggcacg atcgaaacac cgctgattga caaattagca 3328981 ggcacaaaag aacaggaaat gggcgaacaa ttccgcgaag ccaacaaatg gatcacgccg 3329041 ctcggacgtc ttggccagcc caaagaaatg gcaacagtgg cactgttcct cgcatcagac 3329101 gacagctcat acgtcacagg agaagacatc accgcagacg gcggcatcat ggcgtacaca 3329161 tggcctggga agatgctgat tgaggagaaa tggaaggaag aaacgaaata agagagggag 3329221 ccccctctct ttttgtcttt taaagcaata caaccttata tttcttcaca tccaaaaact 3329281 gcaaaaactc cctcgccagc acttcaggcg gatgcgcctt tccttcatcc agccgataca 3329341 aaagcaaccc gataatcatt gcggatacat aatgggcata aagctttttc tctgcgtgaa 3329401 tatcagtttg ctgatgcaga taaaacgatt ccagcgcttt gaacatatca ggtatcacat 3329461 gaggaacacc ccattcccga ttgagaaaat ggacaatggg catgtttgac aaagcagaaa 3329521 gcagaatggc gagcgccttc tccgcttcct ttaaggaaaa ttcattcggg ctggaggcaa 3329581 tcgtcaggtg atcaatgatc tccgcacatg atcgctgtat catggtttgg agcaattcct 3329641 ccttattggc atagtgatca taaaaggttg cacggcggat attgctttta cgcgtaatat 3329701 ctgaaatcgt gatgcccgcg tagtcttgtt tctccgccaa tacatccaga aatgccttct 3329761 gcagcgcctc tctcgttcga accacccgcc tgtcgatttg cttctccttc tctcgctctc 3329821 ctggcacagc ttttccaaac agccaataaa accgcttttg agaaacaagc tcccatacct 3329881 tctggctgat ggcttcagga gacgcggccg catcctcatt cagccaatac aggataatcg 3329941 cgtacgtgta caaggcccga taatgtccat aaatgtcccg ttcaatcggc gttaaattca 3330001 catggatcgg agccagcagc acatcctgct gaaacacatc cttaaaaaaa cgatgaaaat 3330061 gtcctctgtt catcatcaca gaaaaaaagg aacgatgctc atgaacaaag gacagcgtcg 3330121 gatgcaccgt ttgccgtttt ttgttcaaat gaagggtatc catatgactg aaggcgtcaa 3330181 aaagcgcttt gcccagtcct tccttcatgt cttcgatcac atcctcaatg attgaaaact 3330241 tatcctcata ataaaggtag agcgatccgc ggctcacttt ggccttctca gcgatttctt 3330301 tcattgtgat gtgttgaata tctctatctt tcaataaagc cagcagcgcc tctttcactt 3330361 gagcttcggc agattccggc acaaaagaca cctccaatca ttagacagat cttagatata 3330421 tgtacggtaa cgtatagatg gttcaccgtt gtctttctta cagaaaaggt accaccttat 3330481 aataggtccg agaaaagaag aaagcaaatg agggggattt tacaatggaa cagcaagtaa 3330541 aggacgacat ccagcgtgtc tttcagcttc agaaaaaaca gcaaaaagcc ttgcgcgctt 3330601 caacagcgga acagcggaga gaaaagcttc aacgcttttt agattccgtc atcgcccatg 3330661 aagaagaaat catcgaagcg atccgcaaag acgtccgcaa accatatcac gaagtcaaaa 3330721 aagcggaaat cgaaggaaca aaaaaagcga ttagagataa tatgaataac ctggaacaat 3330781 ggatggcgcc taaagaagtc ggttcatcgt taagccctga cgcaaacgga attcttatgt 3330841 acgagcctaa aggcgtcaca ctcatcctcg gcccgtggaa ctatccgttt atgctgacga 3330901 tggcgccgct tgccgcttct ctcgcagccg gaaacagcgc gattgtgaag ctgtccgatt 3330961 tcacgatgaa cacgagcaac attgctgcta aagtaataag agacgctttt gatgaaaaag 3331021 aagtcgcgat ttttgaagga gaggttgagg tggcaaccga actacttgat cagccgttcg 3331081 accatatttt cttcactgga agcacaaatg tcgggaaaat tgtcatgaca gcggctgcca 3331141 aacacttggc atctgtcaca cttgagcttg gcggcaagag cccgacgatc attgacagtg 3331201 aatacgatct gatggacgca gcgaaaaaga tcgccgtcgg gaaattcgta aacgccggcc 3331261 aaacctgcat cgcacctgat tacctgttca ttaaaaaaga cgttcaggac aggttcgcgg 3331321 ggattttaca aacagtcgtc aacgctggat ttatggagga tgatcatacc ccagaccgca 3331381 gcaaatttac gcagatcgtc aatgaccgca acttcaaccg cgtcaaagat ctgttcgacg 3331441 atgccatcga aagaggggcg gaagtggtgt tcggcggcgt attcgatgcc agcgaccgca 3331501 cgatctcgcc aaccgttttg aaaaacgtca cgcctgacat gaaaatcatg caggaggaaa 3331561 tcttcgcatc gatcctgcca atgatgaact atgaagacat cgacgaggtc atcgattacg 3331621 taaatgaccg cgataaaccg cttgcacttt atgtgttcag caaaaaccaa gatctgattg 3331681 acaacgtcct tcagcacacg acatcaggaa atgccgccat caatgatgtc gtcgtccatt 3331741 tcagtgacgt caacctgcca ttcggcggcg tcaacacaag cggaatcggc tcctatcatg 3331801 gggtatacgg attcaaagag ttttctcatg agaagggtgt atttattcag gccgctgaat 3331861 aatcgcatga tcaaaaggcg cttccttaga ggagcgcctt ttattgtaac tccttgacca 3331921 aaagcaattc atcacggata ggtattttat tatctgccag taaaggaatt tcgggcttca 3331981 tctttctggc cgtctcgact gcattcacaa atagtcgatc caaccggtac cctctcttct 3332041 gataaaacgc taatgcatga atattatcat tggttgtgat cagttttatt tgtttgatat 3332101 ttctctctct gcatgcttcc tcggctttct ctagcagagc tgttccgatc cctttattct 3332161 caatgacact atccagcgaa atgatttcac aggcatcttc ttcaaatatg tatgtaataa 3332221 ggccaacaat ctggttatca tcgttgagca ttccataacc atctaattca tcgcagttat 3332281 aaataccgct agaaataacc atttgcggac tgccccagtg tttttgaaaa aacgcggaaa 3332341 caagatcttt aggtacctgg catgtcggaa taatattcat attttcctcc ttttagctga 3332401 acaaaaataa gagaattaac aacctatttt atgtcattaa tccccttatc tagtatttac 3332461 tagaacttat aacttgtcaa aagctgtctg aataccaatt gcgtggattg ataaggatca 3332521 aaatctgaat cctgagattg gaagatttgc tctggggtca atgtctctgc gttctctgat 3332581 aacgtttgaa tcagactttc caaatatcca tttaactctg atttggacga ttcatgtagg 3332641 gattgatgat ttacagcgag ttctctaaat ctgttatcac tgattaattt ttttcgaaga 3332701 gctgctagca tcaagtcaag ccatgcaggc tggccaaatg taatatttaa agctaacgtt 3332761 gcttgatcag atttggtgga gtgccataaa cctcttggca aatacagcat ggttcccggt 3332821 gttaaattaa cgatttctgc atctggcaga tcctcttttg gcggatctcc tttccaatat 3332881 gactgtaaat catcaggata gtaaggagcc tctgataaat catagtgctg cattggattg 3332941 ctcacatttt cattcttggc aagcttccat gttttctcac cttgaatttg aaaaatcaag 3333001 ttggtgtagg cgtcaaaatg ggctttgaat cccccgccat ttttcgccgc gtaaacaatg 3333061 gctttggaag aagtacccgc aggcagtctt aattccgctt tgagtttttc tatccacctt 3333121 ctgacttggg gaataaatag gtcggtgaaa tcaaactcta atgcagcccc tttttcatac 3333181 cactctaaag cctctgcagg tgacacaaga aatctgtctg tgatcccttc agattcttca 3333241 atcacagcat caccaacgac catgactgga ttattgtaga tagccaatac gttttctagc 3333301 gttctaacct tttcaaaccc cggtatgctt gtaaatctct ccacttctcc tctggctacc 3333361 aaaggtttta caggccaata ttcttctaaa aactcactca tcgttacagg actgatgata 3333421 gactccaaaa ccgattcggt tacagcactc atattatccc tcccaaaaaa agtaacttca 3333481 ccacaaagat ataacatttt tttctaaaag taaatattga cagaattatc agaggattat 3333541 aatatttagt tgtgcgtgat agcctatttt tttacaagga aggagggaaa aggatgaaaa 3333601 aggcttataa gaaacctcgt ctttttgaac tgcgccgtgc tgtagcagct ggcggccatt 3333661 aatctcatat agcatttgac atctagtact ctattttagg agggatgctc aatgaaaaaa 3333721 gcttataaga aacctcgcct ttttgaactg cgccgtgctg tagcagctgg cggccattaa 3333781 tctcatatag catttgacat ctagtactct attttaggag ggatgctcaa tgaaaaaagc 3333841 ttataagaaa cctcgccttt ttgaattgcg ccgcgctgta gcagctggcg gtcattaatc 3333901 ttatccaaaa cgattaacgt ttgaggctat cacgccaact tgataaggag gatgctgaag 3333961 atgattacgg ctgaagaatg cagaacgtac aaagaatttg ttgatcttta ccaatcctat 3334021 ctttacccct tgcttggcgc cagactgtcc cggatgtatt cccccaaaaa caaagtcatt 3334081 atcgatatgg gcacaggtcc aggttattta agcattcagt tggctaaaag aacaaatgcg 3334141 cacgtgcatg ctgtcgatat taacccggcc atgcatgaaa tcgctcaaga agaagctaaa 3334201 aaaagcggag taagcagcct gatttcattt gatttggaag atgtccacca tttatcttac 3334261 gctgaccaat atgctgactt catcgtctcc tactcttgcc tgcatcattg ggaagacgtt 3334321 gttaaaggac ttaaagagtg ctatagagtt ctggctccgg gcggaaaaat tgtcattttg 3334381 gatacattta atccccaagg aagccattta gagattatgc gaaaacaaat caaagaaccg 3334441 gaatacttca ggtttgtaag agaggcattt gaagaaagtt attcctttga agacattcac 3334501 cagtttgttc aggatgccgg cattcccaat tattcattag aaacctttca ctttttaccg 3334561 gaggatttta tagaaagctt agatgagctg gaggatgctc ccctgtggga acaaaatgat 3334621 caaagtactg atcatgaaat tgagtctgtc acatggatgt taacgataga aaaagaaaag 3334681 gaaggtgcat tgtaatgatc aatgaatcaa ctgttttatc caaaaatcca gaaatgccat 3334741 caagaaaata tttgaaaagc attattatag agccgggcat cactttaaat gaaatggcat 3334801 cagatattta taaccatatc gacggcaagg tcagcataca tgatatttgc tcaaaaatcg 3334861 tcaatgaata tgatgttgat tatcaaacct gcttagaaga ttgtatggag ctgtttgagt 3334921 tgcttattga tcatgaagca atcaaagtta agcagggggc atgagaattg gaaaaacaaa 3334981 aagtgcttgc tttaccagac gatgtacatg agctgagtac acaccgttct aaatcaatcg 3335041 taaattacat catcactctg cttgcctttg ccaaaaaaca aggattgact catcaagata 3335101 ttgtaagctg gattcacgag caatatgagg aaagaggata ttatgatgag tggagacaca 3335161 ttaacagcca acaaccagtt ggatcatttg tggaactctt tataaaagga agacgtttac 3335221 tttatgacaa aattgaattg tttgaaacag aagataaata tgtcgtaaat acccacactt 3335281 ggtatgaaaa agaacctagt gaggcctttt tttattttga aattgatccc gaagaatttt 3335341 ctgcgtacgc ttccattctc gcaatcgaaa acgcaaaacg tctcggaatt aaaatcgata 3335401 ttgtaaaaga aacagatgta gagacagctt atatctataa acatcaataa cgctattggg 3335461 agggagacat atgtgcgggc tcgcgggtat tataaatctg gctgctcccc gttctcagga 3335521 atgtaccttt catatattga aaggcatggc agatgccatc agctataggg gaccggatga 3335581 tgaacaatat catattgatt ccaaagtcgg ctttgcattt cggcgattgt ccattcttga 3335641 ccttgtaaat ggacagcagc cctttttaaa tgaggatgga tcaatcgtcg ttatggtaaa 3335701 tggagaaatt tataactata aagaactgaa ggcttcttta cacaatcata tgtttaaaac 3335761 gacatctgat tgtgaagtaa ttgttcattt atatgaagaa aaagggattg gatttgtaga 3335821 cgacatcatc ggaatgtttt caatagccat ttgggacaaa aataaaaaca aagtattttt 3335881 agttcgtgac cgctttggga ttaaaccgct tttttacaca gagctaaaac acgagcttat 3335941 atttgcctct gaaataaaat ccctattttc tcatcctcac tgtccccgcc aatttaattg 3336001 gaaagaagca ctctcagaca tttggctaag cggggaagca gccagtaatc ataaagaaac 3336061 cacttccttt tttgtaaaca tccaaaatct cgatgctggc cattatctcg aaattaattt 3336121 gacaacaaat gaacgaaaaa cagcaagcta ttggtcttta caggatattt tgctcaggca 3336181 aggctatcgt gagaatctcc atcccgatga cctgattgaa ggatatagag aactgctggc 3336241 agattcagtc catagatgtt tacaaagcga cgttgaagtc gggttgtttc ttagcggtgg 3336301 cattgattca gctgcagtcg cacattttgc tgcagaaaaa caggatctcc atacgtttac 3336361 agtattaagc caaagtacat ttacaaatga agatgcaaaa tatgcccatt ggctggctaa 3336421 agatttacac cttccaaatc atcaggttct ctatcaatta gggaacgatg agttattaca 3336481 accagagtca tataaacatt tgttatggat ctgtgaaaca ccgttttgcg gaccggaaca 3336541 attatataag tttcatttac ataagtatgc caaagcgata aggccaaacc tgaaagtcat 3336601 gctgaccggc cagggcagcg acgaatttaa cggcggttac agcacgacac tttcaccagc 3336661 cgagaaccca agttgggaag gatttattga atcggtcaat acgatggaga tgaaccggct 3336721 gcatcggctg cagggaaata tctttagagt gtgggaggag cattttggac tttctcctat 3336781 aaacctttct tatttaaaga gcaatgattc cagccaagca gatccttggc aatcgtatgt 3336841 cctgacaaaa taccgtgatc tgcaaatgta taattgctgg catgaagatc ggatcgccgc 3336901 ggctaatcat atcgaaaacc gtgtaccgtt cttggaccat cggcttgttg aatgggtttg 3336961 cggaatacct gatggactcc gtaaagactt gttatgggat aagtcggtat tgcgaaaatc 3337021 attaacaaat gagctgcata caagctatac ccaccggcca aaggttcctt ttttctatgg 3337081 taaggacgtg agatatacac ataaaatgat gtttcatctt ctgaagaaaa acaattatca 3337141 gcttatagag gaggccttct ctcacagcga tgcctccagc ataatacagg ttgaacacat 3337201 tcatgccatc atgacatatt tggaggatga tcctgagttt acaaattttg aatttttatt 3337261 aagactggtg aacatgggac ttttatcaaa aatgactaaa gaaacccctt ctgttcaatt 3337321 agacataacc agccatttag aatcgataac aataaaagac tggcactcac aggaaggtga 3337381 tattgccagt cgtttaaata tctcagccaa taagtgtgaa ggacaagata ttttggcgct 3337441 aaaccctggc gtcactctgt taaggccgga aagcgatagt gagcattgca tctacattgc 3337501 ggaagaagga tttattcagt ttattgtttc ggaggaagac gtcggagctt ggctgcatat 3337561 tctctgcgat attaatggaa aagacacact tcatacgatt ttagacagac atggtgtcag 3337621 ccttgaagaa gtggccaaat atattcaaga agccatcgaa cacaatatca ttttgatcaa 3337681 acaaaaaaat ctgccagaag gagcatatag atgagcatct tttattcgtt ttccgcactt 3337741 aggggattag caatggggat tttttcgcct atttggattc tttatctgat atctaaagat 3337801 tatgatttcc ttcagattgg attaatggga gcggtacttg aaattgctaa gcttatattt 3337861 gaagttcctt ccggcgtttt tgctgatcgt tatggaatta aaatttcaat tgccagttca 3337921 ttctttttct ccatccttac atgggccttc ttccctttta tcgattcagc tgctatttgc 3337981 atactggcta tgatcatatg ggctttatca gattccttaa tttccggttc ttttgaaact 3338041 tggatgagcc gtgtcgcagg ggaagatcga ttcggcaaag aaatgatgaa aaacacacaa 3338101 ttgctaatca cttttttaat tattggaagt attgccagcg ggtatttgta ttcattaaat 3338161 atctattttc ctttcctgct cgttatggtg atctacttat tactatttat ttggatgtct 3338221 gtatttatta aagtcccttc tgtttccgaa acaaatcatg gggatcagaa ccaacatgat 3338281 tcgataaaga ttatcaaaga aagtttaaaa attatcttta acaaaaaaag ggttctttta 3338341 atcgtcatag ccggtttctt tacagccaca gcctatgaca caatttcccg ttactggcag 3338401 ccttttttga gtgatttagg cttttcagaa aagtcactgg gatatatttt tgccctagga 3338461 gggtttaccg ctctcgttct tttgacatta accatcaggt tcgaaaagaa gatcgaaaaa 3338521 aatccatatc tcgctttaac ctcattggat tccatgggca tggtcatgac ttttctattg 3338581 tctagagcat tcaggccgct gggcattcca tgtacagcgt ttttgcttgc aattgaagat 3338641 attcatcatc cgatcgtaac aagttactta aataagtttt tccccgattc atacaagaac 3338701 acacttttct cgttaaactc aggggtagga gcaattggag aaattctttc cggtgtcatt 3338761 ttcggcatca tttccgcagc ctttgggctc tctgccatgt ttgttgttgt agctgtattt 3338821 ctattaatcc ctattatcct ttatacgata gtgcctaaga ttaaagacaa tgatatgaaa 3338881 gttcagattg aaaaatccca gcaagtgtaa atgttttgta tcacagtaag aagaccttct 3338941 tattaaaaga aggtcttctg ctattctatt cagttatttc ccaaaagcca tcagcttcgt 3339001 ataacttcca atataaagtg ttccgtcctc agcgagctga ggagaagaca cgacgttgct 3339061 gtcggtttga tagctccata attcattgcc gtttgcgtct gccgcataaa ccttcatatc 3339121 atctgacccg aaataaaccg ttcccttcgc gtcaatcagc ggcgccgttc tgacagggcc 3339181 gtctgtgtag aatgaccagt tcatatcccc gtttttgctg atggaaaaca gctcgccgct 3339241 tcctgagccg atgtagatat tgccattatg atcaatcgca ggagatgagc tggagaaccc 3339301 gtttagcggg aatgtccatt tcaaactgcc tgttgatgta taagcataca gctgtccatc 3339361 ttggttgccg gcataaatgt ttccgtcctt atcaatcacc ggatatcctt taaacgcatt 3339421 tgacgtcgtt ctggaccatt tcacctgtcc ggttccggag ttgatcgcat aaaacacgta 3339481 attatatgtg ccgacataca cggtgccgtt tttggcaagc accggcacag agctgacgac 3339541 cccatttgtt ttcaacttcc agcgctctgt ccaggttgat tttgacgtcg gtttgatcgc 3339601 gtgaacataa ttatcaagtg ttgagaaata caacgtcccg tctgaaccga tcaccgtttc 3339661 agagcttggc ccgccgctta acggaaccgt tgttaaaatt tctcccgttt ctttgtcaat 3339721 aaaataaatc tttttgtcat aggatgccaa atagataacg ccgttggtcc caagtacagg 3339781 agattgcgta tatgtttttc caagattgcc cgtcacccat ttgactgagc cgtctggatt 3339841 aaaggctttc atttccccgt ctctggaatg aagatatact gtgccgtctc cgtcaatcac 3339901 agcccccgct ccattttgcg gagtcgttct gatgtcgttt tgccatttca gcgtcccgtc 3339961 tgtatttccg gcgaaccggc tttcgcgtga ccagttaaac atggcaggcg ccatcgcttg 3340021 tacatcatat cttcctggca aaaagccaga tgctccatta ttttgagaaa acaccgtttc 3340081 cgccgcataa gcagctgtcg gctgaagcac tttggcagcg ggcacatcag aaacagcgcc 3340141 ggccgaaaca gccgccgcca ccgcagctcc cgcaatcaaa gctttcatac gaaatgactt 3340201 gaccatcatt gagaccccca ttatatgtaa cttctaattt gtgaccatca taacatattc 3340261 atccatttta taaatctatt tcacaaaaac atcacaaact agaaaactat gtaagagtat 3340321 tcacggacgt tttttcagca cccgatcgaa atgcagccac aaaccaaatg acgttgacag 3340381 cagccgcagc gagactaact cccaaaacaa agatcacctc agaaagcaga tggtcactaa 3340441 agaaactaaa catcaagata aaaccggccg aagacaaatg aatcaaaagc ccgaagccgc 3340501 aaagcaccgc catgacatac ctcattgcat cgactccgag catataaacg agaaatggaa 3340561 tgaaatacaa gacaaggatc ataccgacag ctgaccacat gccagctgaa ttaaactgat 3340621 tggccgccgc tcccgttccg gccagcggcg aaagtgaagc cgccacaatc acggcgcaaa 3340681 aaagaaacgc agaaatggtt gtcatgatcg ccacgctatt tttttttgac atcaaactcc 3340741 tcctttaata gaaatattaa ccttttttat tataagtaag ttgaatgtta tattcattat 3340801 atttttaaaa aattccagaa tacatacaca aatgctatgc ttctttctag tatatttata 3340861 tagtaaaaaa caaaggataa aagactcatt tttctgtaat atcaggattt tatcaccata 3340921 ccatattgca tgtacatgtt tttcaaagta tactattcca gattaattca gaggagagag 3340981 aaaaatacat ggaaaaacca gcaggatttt ggattcgttt tttagcttat tttattgacg 3341041 gcattattgt atctgttcct agttatatta ttctatttat tatcaattct gtgtttgtag 3341101 ctggggctgt ggcaacaaac ccttacatga cggaagaaga gtatttagtg aaatacatga 3341161 cgcttgcatt tttgcctact atgctgatca tgatcgtcat cagcgtgtta tattacgggc 3341221 tgctcacagc ttctaaaatg caaggcacac ttggcaaaaa aattcttggc ctgaaagtgg 3341281 tcaatgaaca aggtgaacgg gtttctgtcg gacagggaat tggccgttac tttgcctata 3341341 tcttatctgg aatcatcttt tatatcgggt ttatcatgat cgcctttgga gagaaaaaag 3341401 gcctgcatga catcatttgc aaaacacgtg tcgtgtataa ataatagaaa aaagtctaga 3341461 cgccaatagg catctagact tttgttttct ttgcaatagg ctgccacgac agatacgtag 3341521 cgcttctcca caaccactca aacggcccca tccgaaagac acgaagccaa aggtggctga 3341581 agaccatttg aacggcacaa acagcaattg taatgagcac accggcagca gggtacactt 3341641 ttccatacag gcccaagccg taatgataaa aaatccaagt acacacaata gactgcatca 3341701 aataattggt aaatgccatc ctcccaacag cggagaatga ttgcagcact gttctcactc 3341761 ttgttttatg ataaagatag acaaccgttg taacatagaa aaacatgagg aaaggcgcgc 3341821 caatcagcaa acatatttct ttatccgtta cactgtacag cacctgggcg ccgatgccga 3341881 tgacaagccc agccatccat aatcgtttta atcctttgcg atgcttttcc ggttcatgca 3341941 aataccgtga ttttgctgcc gcagctccca gcaaaaacat gctgaaatat ggaatggatg 3342001 caaagaagta gttgagcgga ttatacgtaa gcatgccatt cgaagacatg taaacaagac 3342061 ggtcgtggat ccgctgttct gcaatatcct tcaggctgcc gcttccataa acatgaatcg 3342121 cttgttttgc ctgctgtgtt accgcttgta cccattcctg tccgtttgat tgatcaaaac 3342181 ttgtcaacat gaacggaatg gaaaacagaa gatacaaaga gaccgcccat atcagcagtg 3342241 ttttcggctt tgcttttcga aacaagagca ggacaaatcc gagcagggca tattctgtta 3342301 aaatatcccc gtcccatatc aaaaaggcat gaatcgttcc aaacaagaga agcgccatta 3342361 accttctcac atataacgga acaaaccgtt tccctttgtt ttctgctctc tccatcatga 3342421 caaccatgcc aaatccaaat aaaaaggaaa acaataaaat acattttgtt tgaatgaaga 3342481 atttcagtat gtctgcggcg gcaaaatcag cttcagacca cttatccatg aaaaaattct 3342541 cttttccaag catagacaaa tacatatccg gataactgaa atgtgccaga ttgacaaata 3342601 agatgccgaa aatcgccatt cctctcagca catcaagcac accgatccgc tcatttgtta 3342661 aagtcggctg taatgaagac atagccatca cgctcctttt ttctgtacct taagggtagg 3342721 aaaaaatgaa gcgcggtaac atcgatttag gtgtcaggcc ggcatgaaaa ccttacaatc 3342781 ttgtcatctt tatggtttca tcacctttaa atctaatgct tcgatattct gcaaaatgcg 3342841 atcaaagcgc aaagcctgag gctcacatgg gaagatgtgg ccttcatacg ggtcgcctaa 3342901 cgtccggaaa aacggttcaa ataaaccagg aaccaatacg cccaccatct ttgtatagtg 3342961 agaatcaagg cgataggagt gaacggtatt tgcagggaca tgcaggaaat ctcccggatt 3343021 cagctgaatt tcctggccat ctgtccacat cgtcatctgg ccttcaaggc aataaaatgt 3343081 ttctgtatga tattcatggt agtgatcaac gattcggtca cctttagggc cttcagatga 3343141 tacgacgata aactggccat ctgtattttt ttgtgcagcc acaatgcggt gaagctgatc 3343201 tccagtcaac agacgatctc cttctccaga ttcaagaacg tatggaaccg ctccatctgg 3343261 cagctctgta agttccgcta atttggccga acatgcaggc tttgcttcat ctagaaatac 3343321 aatgtccgct acagcggctg cttctgcaaa tcgctcgttt gagacttctt cgcttgcgta 3343381 cggcggatgt tcagcgtgat catacggatt cccaataacg gaatacaagt gcgctacgtt 3343441 tcctttcatc gtgtaagaca ccagtcttgt tctgtggctc tgcatccggt agctgtgcgg 3343501 tgttcccgcc ggaatgttgg cataatcacc tgatattaat aaatagcgtt caccatcaag 3343561 tgtcagttcc agtttcccgt ccaaaacgag aattccttca tgtgtgtcct tgtggacgtg 3343621 aagcggaaag gcatctcctt ttcccccgga aagaagcacg atctcaaaca aatcacctgt 3343681 gctcctccca ttcgccatca ccgtggcaac ctgtctgccg aacagatagc gctcgccttc 3343741 tccgctccgg agcaaataag gcattttttc tttaggcaat gaatgtgtac ataatgtttt 3343801 catattatcg cttcctccaa tttagaccag tctatatatt atcattcatt tgtctagacc 3343861 gttctatata attgtaggag aaaggataac aaaatgctac cctttttttc tcaccagcac 3343921 tggtatttgt tcggcaatga gaagaagagg cgttttgtct ttattcgtta acgaaagcat 3343981 gatgccgccc tcaatcatcg aattaatcag cgttccaagc tgatttgctt cttcttctgc 3344041 aaatccgttt tccattaatt ttctggcaaa aaccgcttcc cagcttttaa acaccttcat 3344101 gcaaaccgtc cgcagcggtt cactgattaa cgctgtctca ctcgccagca aaccgactgg 3344161 aataccttta atgctttctg tgttgtcaaa ttggctggct gtttttttga taaaaagctg 3344221 aatcgcttca acaggatcag aggattcatc catgctttgc tgtatcagat gttcaacgat 3344281 cttacctgta tatgtaaccg cttcaattgc tagttcttct ttgccattcg gaaaaaagtg 3344341 ataaagcgat ccttttggag caccgctttc ttttacaatc tggttcaaac ctgtcgcgtg 3344401 atatccttgc agctggaaca gacgtgacgc cgtgtgaagg attttttcac gtgaatctcc 3344461 tctgctagtc attaaaacat tccctcctag gtatggtaga gcgacttata taatataaaa 3344521 aagaaccctg tgattgtcaa aaggggtaag acccttccgg atggggtaat gtacaaaaac 3344581 agcgtctagg agggatctct caatgacaat cgatcattca gtcacaaata cagagcagct 3344641 tgaacaacag aaccccgcca taaaaacaaa gctcaaactg aaaaagctta aggatcaggt 3344701 gatcgtcatt accggcgctt caagcggtat cggacttgtc acggcgagaa tggcagctga 3344761 aaaaggcgca aaggtcgtgg cagcagcgcg aaatgaagag gcgctgaagg agctcactga 3344821 tgaacttaag gaaaaagggc acgacgccat atgggtaaag gcggatgtcg gaaaagaaga 3344881 ggacgtcaac cgcatcgcag aaaccgcgat cagcacattc ggccgctttg atacatgggt 3344941 caacaatgcg gccgtctcga ctttcggaca cgccatggac gtcaccgtcg aagacatgaa 3345001 gcgcatgttc gacacaaatt tctggggacc tgtttacgga acaagagcgg ctgtcaaaca 3345061 ctacaccggc agaggtgtgc cgggcgcact cattaatgta ggaagcctgt tcggagacag 3345121 gggaacggtc attcaatcca catatgcatc tgccaaattt gcgcttcacg gctggacgga 3345181 aagcatccga atggagcttg aaaaggaaca ggcgcccgtc tcggtaacgc tcatccaccc 3345241 gggcagaatt gacacaccat ataacgagca tgcgcacagc tacctcgaca aacagccggc 3345301 tcattaccgc tccatgatct atccgccgga agcggtcgcc gaagcgatcc tgtttgccgc 3345361 cgaacaccct aagcgcgaca tgtacatcgg ctcacaggcc aaagccatcg ccatgctggg 3345421 cgcgcttttt cctcgtctga ccgacagact gatggaaaaa atcatgtatc acagccagca 3345481 tgccgaaaga ccgtccaatc cgagagaaga aagcgctctt tatgatgctg gctgcggtat 3345541 gcatgacaga ggcacaaata aaggatggat gaggtcaaga agctactaca caaaagcgac 3345601 gaagcgccca attgtatcgg cggctgttgt tgccggacta gtggcttggg ctgccgccaa 3345661 acgatgcaga taatctctga ccataagaaa aacccatgct gttccagcga accatgggtt 3345721 tttcagctgt taatcgataa aagccttgtt catacgctgc agcagctcgc cgaacatctc 3345781 tttttcctgt gttgaccatt ctttcagcat ctgttcataa cgttcaaggc gcttttgctg 3345841 atcggctttt aatagttgtt tgccgagttt tgtaatggta aacaggctga ctctcccatc 3345901 agacgggtct gagaaacgat agatgagctc ctttgcctct aatgcagctg cttgtcttga 3345961 aagagtagaa atatcaagct taaacgattc agccaattcc ttaacacgag caggcccaaa 3346021 ctcatccaat tgtctcagta ataagtacga agatctctcc aaattccctg ttcttttctc 3346081 cgattgatcc agataaacag ctctcctgat aaaagtcgtc agctcatatt caattaattc 3346141 aactggattt tgattttgca atcgctctcg ctccctattc caatctccgg cattgacaac 3346201 atcatatata cttgtataat acaaatgtac attaactgaa taaatacaag tcgttatatg 3346261 actaaatcaa ttattatact tgtatagtac aatcatataa aaagaaagta aagcgattcc 3346321 tcagaaccat cctagaagca agcaccagaa aggaggaagc tgttctgatt ggagagcagc 3346381 acttgatgtg aaagtcatac gaattatttt gcaagtgttg atattatatg tattttttat 3346441 gatcggggaa gccattcagc atctgtttca tttacccgtg tcaggaagca tcgttggatt 3346501 ggtattgctt ctgatctgct tgggcctccg tattgttccc gtctccatca ttgaagacgg 3346561 agcagggttt ttattatcct tccttccatt gttgttcatc ccggcaatga caggagtgat 3346621 aaactatccg tctctcattt cattcaatgg cctgatgctg ctgattacag tcgttctcag 3346681 caccatcgtc acgatcattg cggctggatt cgccagccag ctattagaga aaaaagcaaa 3346741 aaaacgggag gagaaagaga aatgcagcaa gcatgtatcg cgatcattat aattctttta 3346801 acagttgccg cttatttagc gatggtcaaa ctctataagc gattcccgct tccatttctg 3346861 atccctgttc tgacaacgac aattttgatt gtagcggctt tgatgatgtt tcatgtttcc 3346921 tatgaaggct atatgatcgg ggggaaatgg atcaattctt tgcttgggcc ggctgttgtg 3346981 gcgctggcct atccgcttta taagcaatgg catatcattg tcaaacattg tgttcccatt 3347041 ttaggcggcg tcctggtcgg cttatgcatg ggaatgatca gcgggctgat cttcgcagaa 3347101 gcattcggga ttgatcatga tctcttatta tccattctgc caaaatcgat cacaacccct 3347161 gtcgctattc agatcgccgc cggtcttggc ggcgtccctt ccatgacagt cgtatttgtc 3347221 atgattgcgg gcttttcagg cgtcatcctc gggccgcttt tcctaaaatg gcttcgcata 3347281 cgcagctccc taggacaagg cattgcatta ggcagcgcct cccatgcact gggtacctcc 3347341 aaagcgttgg aatatgggga attggccgta tccatgagtt ccgtctccat gacgctttgt 3347401 gcggtgctcg gctcattctt cggcccgctc gtcgtctggc tgtttcatat ttaacaaaga 3347461 aagactgccc cgggggaggg cagtcttttt cgtttaagaa gcaaaaaaat caatcaacgg 3347521 ctgaaagtcc ttagataaat caacgtcatt cggttctgct tgaagcaggc ggtcaatcat 3347581 acgctccagc tcctcaacat cattcttatc cgtatattca atgaagttta agctttcaag 3347641 ccaatcccga tatgaatgtt tggctttgcc atagctgttt ccaaagacaa ggcaaggtgt 3347701 tttggtgata atcgagaaaa tcatcgcgtg aaggcggtcg gtaatcacca atttactgga 3347761 gccgatgcgg tccagcatct ccataaaatg cttttcacga tcagcgtaat cgatggtgtc 3347821 taccgtatcc agcaccgtat cggtacgctc tgtgtaagtt gttttttctg cccattgctt 3347881 catctgtgaa ataaaatctt cgtcagtcac tttctcctta tccgctctta aaataaagag 3347941 aacgccgtcc cgctcgagct ctcgcggcac aatatccaag gaaagcacca tgtccggtgt 3348001 aaagatcaca ttggagttga aggtctcttt cacaacatcc agtgtttgcg tctcacgcgc 3348061 agcaatcgtt aagtttgtat tttgatggta cgcatcctgt gtttttttct tttccttctg 3348121 tccttcctct gtatcctcaa aataaacgga ttgtggcaga gaaattgatt tgtagtcttt 3348181 aaacgccgaa aagacctttc ttctgtcttc ctcaatatcg agataaaggt ttcctaaatt 3348241 ccctccgcct gtaaagcaga caatatcgtc ttcacgaatg atctccttca ccagttcaat 3348301 gccctcatcc gtcgcataat ccataatctc aatgtattca taatacggaa aatgattttt 3348361 gataaatttc tcttccgcat acgcaatcgc ttggtcgcca atgtttgtgt agctagggga 3348421 accaaacaaa aatacttttc gtttatcatt taacagagct tccggctcca catttggcgc 3348481 aatgcctttt actagttttt tgcctttgat ttcttgtaca gtcatatctg cgtcctcctt 3348541 ctgggatgaa ttcctcattg tgtgttaact gtctctaccc aaaaagaagg atggctatgc 3348601 attggcatgt gcatcggcta tatcagaaac atcgttttcg ccaatttgat agacgctgca 3348661 atgtcccgcg ccgttctttc catatattcc gcggcatgtt caaacgcgtc ttctagtggc 3348721 acggctccgg ggacgatgct gaaaagcgca tcgattccgt gttgatagac ggcattactg 3348781 tctcgggaaa ttgatcccgc aatgccgata acgggcacat cgtatgattt agcggccttg 3348841 gccaccccga tcggtgtttt tccatgaacc gtttggctgt cgattcgtcc ctcgccggta 3348901 atcacaaggt ctgcatcctg aacgatactt tcaaaatcaa ccgcttcaag gacaatatca 3348961 atgcctcttt tcaggtcagc ctgaagataa gttagcaggc tccatccaag accgcccgct 3349021 gcaccggcgc cctctgtatc tcggaaggtt gatccgagcg ctttttctgc catatcagcg 3349081 aaatggctta cgttctggtc tagtacatcc aacatgtcgg ccgtcgcgcc tttttgcggc 3349141 ccgaaaacag ccgtagcacc ctttggtcct gttaacggat tgtccacgtc acaggcaact 3349201 tccagtttga cattccgcaa tctggaatca agcccgctca catctattga tgcaagctga 3349261 gataacgcgc cgccccctgg gccaatctcg ctgcctgagt tatcaagaag ccttccgccc 3349321 aatgcctgaa tcatcccggc tcccccgtcg ttcgtggcgc ttccgccgat tccgatgatc 3349381 aatcgctccg ctcccgcatc aagagctgct ccgattaatt ctcccgttcc ccttgttgta 3349441 gtgatgagcg gatttcgctt atctacaggc accagatgca gccctgaagc agcagccatt 3349501 tcaatcacag ctgttctccc atctcccatc atgccaaaga aagctctcac cggttccccc 3349561 agcggccctg tgacaacttg ctctatgatc cttccattgg tcgcatcgac cagagattga 3349621 acggttccct cgccgccatc cgccaccggc aattttctgt aatcagcacc cggaaagacc 3349681 gatttgaaac ctctttctat cgcttcggct gcctccagag ctgataagct ttccttaaaa 3349741 gaatcaggtg caatgatgat tttcatccaa atcgcctctt tcaaaacatg attcacttaa 3349801 cctattgatc tccaatgtac cataattgat ctggaaatac ataccatgca atatggtaaa 3349861 aatttaaata aaaattagaa atgaaagtgt ttgcataaaa gaaatattca cgttatcata 3349921 cttgtataca agtatactcc ttgagtgagg aaggtgagtg tatgctagac tccaaagacc 3349981 tgttgtatcc cgcaaaatgg ctctcaaaag cgtcaaccgg agttcgtgtc gcatacgagc 3350041 tgagaatgcg gatcgtttca ggtctgattg aaagcggtac cattttatca gaaaatacaa 3350101 tcgccgccga gttttcagta agccgttcgc cggttcgcga agcgctaaaa atactcgcat 3350161 ccgaaaaaat catccgctta gaacgaatgg gagcggtcgt aattggttta actgagaaga 3350221 aaatcgcgga aatttatgat gtgcggttac tattagaaac atttgtcttt gaacggcttg 3350281 tcaaaataga cattgagcct ttagttaagg atctcagcaa aattcttgaa atgatgaaag 3350341 tctcaatcaa atatgaggat gctgacgaat tttcatttca agatgtgctg ttccatgaaa 3350401 cgattatccg agcgattgat cattcataca ttcagatgat ctggaacaat ctaaaacccg 3350461 tcatggaaag ctttattctt ttatcgatgc gggtacggtt aaaggaaaag tatgaagact 3350521 tcacaaggat tttagataac cacgagcttt atattcaagc catcaaaaca aaggataggg 3350581 cgctgatgat tcagtctctt caccaaaact ttgatgatgt gcaggataag gtagaagacc 3350641 tatggctctc acaacaaatg ctggcaaaag gagctgaata caacaatgac tagttatatg 3350701 ttaggaatcg atatcggcac gacaagcaca aaagctgtgc tgttcagtga aaacggagat 3350761 gtggtacaga aagaaagcat cggctacccg ctctatacac cggacatctc aacagctgaa 3350821 caaaatccgg aagagatttt tcaggcagtc atccatacaa cagcgagaat tacaaaacag 3350881 catcccgaaa aacggatctc tttcatttcg ttcagcagcg ccatgcacag cgtcattgca 3350941 atcgacgaaa atgacaagcc gctgacgcca tgcattacat gggccgacaa cagaagtgaa 3351001 ggctgggcgc ataagatcaa agaggaattg aacggacatg aggtgtacaa acggacggga 3351061 acaccgattc atccgatggc accgttaagt aaaattgcct ggatcacgaa tgaaagaaaa 3351121 gaaatcgctt ccaaggcaaa aaaatatatc ggcatcaaag aatacatttt taaacagctg 3351181 ttcaatgagt atgtcatcga ttactcattg gcatcagcga caggcatgat gaacctgaag 3351241 ggcttggatt gggacgaaga ggcactgcgc atcgcaggca tcacgccgga tcacttatcc 3351301 aaactcgtgc cgacaaccga gatctttcag cactgcagcc cggaaatagc gatccaaatg 3351361 ggaatcgatc cggaaacgcc ttttgtcatc ggcgccagcg acggcgtgct gtccaacctc 3351421 ggcgtcaacg ccattaaaaa gggtgaaatc gccgtcacca tcggtacaag cggtgccatt 3351481 cggacgatta ttgacaagcc gcaaaccgat gaaaaaggga gaattttttg ctatgccttg 3351541 acggacaagc attgggttat tgggggacct gtgaacaatg ggggcatcgt ccttcgctgg 3351601 atcagagacg agtttgcctc ctccgaaatc gaaacagcga cacggctggg cattgatcca 3351661 tatgacgtgc tgacgaaaat tgcccaacgc gtcagacccg gttctgacgg tctgctgttc 3351721 cacccatatc tcgccggaga acgcgctccg ttgtggaatc cggatgtacg cggctcattt 3351781 ttcggcttga ccatgtcgca taagaaagag catatgatac gcgcggcatt ggaaggcgtc 3351841 atttacaacc tgtacacggt gttcttggcg ttaactgaat gcatggatgg cccggtaacc 3351901 cgcatccaag cgacaggggg ttttgcaagg tcggaggttt ggcgccaaat gatgtcggat 3351961 atcttcgaat cagaggttgt cgttccggaa agctacgaaa gctcatgtct cggcgcctgc 3352021 attttaggcc tgtatgcaac aggaaaaatc gattctttcg acgccgtgtc cgatatgatc 3352081 ggcagcacat acagacatac gccgatcgaa gactcagcca aggaatacag aacattaatg 3352141 ccgattttca tcaatctatc aagattatta gaaaatcaat atacacaaat tgcagattat 3352201 cagaggggct taatcacaca caaatagtac atgacatgaa ggggagggca ttaccatgcc 3352261 gttaatcatc gttgcacttg ggatcttagc attactattt ctgattatgg gcttaaaatt 3352321 aaacacattt atttccctgc tggtcgtatc gttcggcgtg gcactggcac tcgggatgcc 3352381 gttcgataaa gttgtcagct ccatcgaagc aggaataggg gggactcttg gccacatcgc 3352441 gctcatcttc ggactcggtg cgatgctggg caaactgatc gcggattcag gaggcgcaca 3352501 gcgcattgcg atgacgctcg tcaacaaatt cggtgagaaa aatattcaat gggccgttgt 3352561 cattgcctca ttcattattg ggattgcgtt attttttgaa gtaggactgg ttctattaat 3352621 tccgattgtc tttgcgattt caagagaatt gaagatttct attttatttc tcggaatccc 3352681 gatggtcgcg gcactatccg tcacacacgg tttcctgccg ccgcacccgg gacctacggc 3352741 gatcgccggt gagtatggcg caaacattgg agaagtgctg ctgtacggct ttatcgttgc 3352801 tgttccgaca gtgctcattg cagggccgtt atttacaaag ttcgcgaaaa aaatcgttcc 3352861 tgcatcattt gcgaaaaacg gcaatattgc atcactcggc acacaaaaaa catttaacct 3352921 tgaagaaaca cccggctttg gaatcagtgt ctttactgca atgctcccga ttatcatcat 3352981 gtcggtcgcg accattatcg acctgcttca agaaacaatc gggtttgcag ataacggagt 3353041 tttagctttt atcagattga ttggaaacgc atcgactgct atgattattt cgttattggt 3353101 cgcagtctat acaatgggca tcaagcgcaa cattccagtc aaaaccgtga tggattcttg 3353161 ttcaactgcc atttcacaaa tcggcatgat gcttttgatc atcggaggag gcggcgcctt 3353221 caaacaagtg ctgatcaacg gcggtgtcgg cgattacgta gcagacttat tcaaaggaac 3353281 ggcattatcg ccaatcattc tggcatggct catcgcagcg atcctgcgca tttctctagg 3353341 atcggcgact gttgccgcac taagcacaac aggtctggtc attccgttat tgggccattc 3353401 tgatgttaac ctggcgttag tcgtactcgc aacaggagcc ggaagtgtca tcgcttcaca 3353461 cgtcaatgac gccggcttct ggatgttcaa ggaatacttc ggattaagca tgaaagaaac 3353521 attcgccaca tggacattgc tggaaaccat tatttccgtt gctggactgg gattcatttt 3353581 attgttaagt ttagttgtat gaaattaaga aggagctgta acacatgttc aattcgattg 3353641 gtgtcatagg cttaggcgta atgggaagca acatcgcctt aaacatggca aataaaggcg 3353701 aaaacgtcgc tgtctataat tacaccagag atttaacgga ccagcttatc caaaagctgg 3353761 atggacaatc tctcagcccg tattacgagc ttgaggactt tgttcaatcg ttagaaaaac 3353821 caagaaaaat ctttttgatg gtcacagcgg gaaaacccgt agattccgtc atccaatcat 3353881 taaagccttt gcttgaagaa ggcgacgtca tcatggacgg aggaaactcc cactatgaag 3353941 acacagaaag aagatatgac gagctgaagg aaaaagggat cggctacctg ggagtcggca 3354001 tttccggcgg tgaagtcggt gcgttaacag ggccttccat catgccgggc ggagatcgcg 3354061 acgtctatga gaaagccgct cctatcctga cgaaaatcgc agcccaagtc ggagatgacc 3354121 cttgctgtgt ctatatcgga ccaaaagggg cagggcactt tacaaaaatg gtgcacaacg 3354181 gcattgaata tgccgacatg cagctgattg cagaagctta tacgtttcta agagaaacgc 3354241 ttcgtctgcc gctagatgaa attgcatcta tttttgaaac atggaatcaa ggtgagctga 3354301 aaagctattt aatagagatt acagctgaga ttttacgcaa aaaagacgaa aaaacaggac 3354361 agcctctgat cgatgtcatc cttgataaaa ccggccaaaa aggcaccgga aaatggacga 3354421 gcatgcaggc gattgataac ggcatcccgt ccacgatcat cacagagtcc ttgttcgccc 3354481 gctacttgtc atctttaaaa gaagaacgga tggcagctca agatgtatta gcaggcccgg 3354541 aagccgaaga aaaacacttg gataaagaca cttggattga atacgtcaga caggctcttt 3354601 acatggggaa agtatgcgcc tatgcacaag gctttgccca atataagatg tcatctgagc 3354661 tttacggctg gaatctgccg ctcaaagaca tcgccttgat tttccgaggc ggctgcatca 3354721 tccgcgctga tttcctaaac gtgatcagcg aagcattcag tgagcagcca aatctggcta 3354781 acctgctgat cgcgccttat ttcacagata agctccatgc ctatcaaaca ggcctgcgaa 3354841 aagtcgtttg cgagggtatc agcaccggaa tctctttccc atgcttaact accgcgctct 3354901 cttattacga cggctaccgc acagggcgtt ccaatgcgaa cctcttgcag gcacagcgcg 3354961 attactttgg cgctcacacg tacgaacgga ctgatatgga cggcgtcttc catacgaatt 3355021 ggtctgaata acctgtatta aaaacacggt cagtttcaac tgaaccgtgt ttttttcttc 3355081 tatcccaaac aacagaagac ataagttatg ttttaaatat cataaacagt gatacaataa 3355141 tagctagaaa caatccccaa gatcatcatg tgacagcaga ttgctgttcc gttctattct 3355201 gcttttggcc attgtccttt gcccttgacc atggtgtcat aaaatgttca aatgccaaaa 3355261 cggcctggca ttctgattta caaaagtccc tgaaaacctt atctaattga gaatcagcct 3355321 ctcatttatt ataaaagaaa tgcctaaatc ctacctgtca cacctttatt aagatgaaaa 3355381 aaagtaggtt atggcttgac aaaaaatata tattaattaa taattcatat ataattagaa 3355441 ttattattga aagcgattat gctttctaat acatttttag gaggaatata cattatgtct 3355501 ttaatcggta aagaagtact tccattcgaa gcaaaagcat tcaaaaacgg tgaattcatc 3355561 gatgtaacaa acgaagattt gaaaggccaa tggagcgtat tctgcttcta cccagcagat 3355621 ttctctttcg tatgcccaac tgagcttgaa gatcttcaag aacaatatgc tgcacttaaa 3355681 gaattaggtg ttgaagtata ctctgtttct acagatactc acttcgtaca caaaggctgg 3355741 catgacagct ctgaaaaaat cagcaaaatc acttacgcaa tgatcggtga cccatctcaa 3355801 acgatctctc gcaacttcga tgttcttgac gaagaaactg gccttgctga ccgcggaaca 3355861 ttcatcatcg atccagacgg cgttatccaa actgttgaaa tcaatgcagg cggtatcggc 3355921 cgtgacgcaa gcaaccttgt aaacaaagta aaagcagctc aatacgttcg tcaaaaccca 3355981 ggtgaagttt gcccggctaa atgggaagaa ggcggcgaaa ctcttacacc tagccttgat 3356041 ctagtaggta aaatctaagg agtgcattca attggtactt gatgcaaata tcaaagcaca 3356101 attaaatcaa tatatgcagc taattgagaa tgacattgtt ctcaaagtta gcgcaggcga 3356161 agatgacact tctaaggaca tgctggctct cgttgatgag ctggcttcca tgtcatcgaa 3356221 aatttcagtt gaaaaagctg aattaaacag aacgccgagc ttcagtgtca atcgtgtcgg 3356281 agaagacact ggcgtgactt tcgccggtat ccctctgggc cacgaattca catcattagt 3356341 gttggcgttg ctccaagtga gcggcagacc gcctaaggta gaccaaaaag tcattgatca 3356401 ggtgaagaag atcagtggtg aataccactt cgaatcttat atcagcctga catgccacaa 3356461 ctgtcctgat gttgtacaag ctttaaacat gatgagcgtg ctgaacccga acattacgca 3356521 cacgatgatt gacggtgcag catacaaagc agaagttgaa agcaaaaaca tcatggcagt 3356581 gccgaccgtt tacctgaatg gcgaatcctt cggaagcggc cgtatgacgc ttgaagaaat 3356641 tcttgcgaaa atgggcagcg gcacagatgc atctgagttt gctgacaaag agccgtttga 3356701 cgttcttgtg gtcggaggcg gacctgctgg tgcaagtgca gcgatctaca ctgcacgtaa 3356761 aggcatccga actggtgttg tcgctgagcg cttcggcgga caggttctcg acaccatgag 3356821 catcgaaaac ttcatcagcg tcaaagcgac ggaaggaccg aagctagcgg caagtcttga 3356881 agagcatgtg aaggaatatg atattgatgt catgaacctt cagcgtgcga aacgccttga 3356941 gaagaaagat ctgttcgaac ttgaactcga aaacggcgct gtcctgaaaa gtaaaacagt 3357001 gatcctttca acaggtgcac gctggcgcaa tgtcaacgtc cccggtgaac aagagttcaa 3357061 aaacaaaggt gtcgcatact gcccgcactg tgatgggcca ttgtttgaag gcaaagacgt 3357121 tgcggtaatc ggcggcggaa actctggtat cgaagcagcg attgatcttg caggtattgt 3357181 caatcacgtt actgtactag aattcgcgcc ggaactgaaa gcagacgaag tcctgcaaaa 3357241 acgtctctac agcctgccta acgttactgt cgtgaaaaac gcacaaacaa aagaaatcac 3357301 aggtgatcag agtgttaacg gcatcacata tgtagaccgc gaaacaggcg aagaaaaaca 3357361 cgttgaactt caaggtgtat tcgtccaaat cggtctcgtg ccaaacacag aatggttaga 3357421 aggaacggtt gaacgcaacc gcatgggcga aattattgtc gacaaacacg gcgcaacaag 3357481 cgtaccaggc ttatttgctg ccggcgactg cacagacagt gcgtacaacc aaattattat 3357541 ttctatggga tcaggtgcaa ctgccgccct cggcgcgttt gattacctaa tccgtaacta 3357601 atataagaaa tccgctatat tgccagattg gcaggatagc ggatttttct ttttctacag 3357661 aaaaaaaccg aaccaggcac tacggtaaaa gtgctcgatt cgagcgcttc ttatagttcc 3357721 tcaccattcg tttgaatgac atttttatac cactcaaagg agtctttctt atatcgtttc 3357781 atggatccgt ttccttcatt gtcacgatca acatagatca tgccgtagcg ttttttcatt 3357841 tcgccagttg tgaaggagac aatatcaata atgccccacg gcgtgtagcc aattaaatca 3357901 acaccatcgt acgtgaccgc ttttttcaat gcttcaatat gcgattttaa atattgaatg 3357961 cgttccggat catgaacctt gccgtcctcc tccagcgtat ccactgcgcc aaagccattt 3358021 tcaacgatga ataacgggat ttggtatcgg tcataaaaac gatttaacgt atatctcaac 3358081 ccggttggat caatcgccca tccccagtca ctcgaagtga tgtacggatt ttcgacacca 3358141 ttcggcaagc cgccatttac aatatcgcca gtgttatcat ttttcacatc gcttttcaca 3358201 gttgttgaca tgtaatagct gaagcctaag taatcgacgg ttccgtttct taaaatctca 3358261 tcatcgccgt cttcgaatgt gatgttgtag ccttcgcgtt caaattcctt caacgcgtag 3358321 cttggataat aaccgcgaac ctgcacatca gggaagaaat agcgctgcct catttcttct 3358381 tcagccagca tcacatcttc aggattggag gagaaaggat aaatcggcac gtgtgatacc 3358441 atggccccaa tctggaactc tggattgatg tcttttcctt ttgccactgc taaggcgctc 3358501 gccactaatt catggtgcgc cgtttgatac atgacttcct tggcgttttc gttttcgcca 3358561 accacaacac ctgaattcgt ccataggaac agcggattgt tcacatccat ttggttgtta 3358621 atctcgttaa atgtcatcca gtacttcact ttatctttgt aacgggtaaa gcaagcctct 3358681 gcgaagttga cgaagaagtc cacgactttc cggtttctga agccgccata ttctcttgcc 3358741 aggtgcagcg gcatttcaaa gtgagacagg gtaatgaccg gctcgatccc atgcttcagc 3358801 aattcatcaa acacatcatc ataaaactgc aaaccagctt cgttcggttc agcctcatcg 3358861 cctttcggaa aaatccggct ccagccgatg gacgtccgca gacattttaa tcccatttcc 3358921 gcaaacaaag cgatatcttc cttgtatctg tgatagaaat caatggcttc atggtttgga 3358981 taaaattcgt tttcttcaat cgtgtcagtg atttttctcg gcacgccgtg cgcacccgct 3359041 gtcatcacat cgacgacact cggcccttta ccgccttgat tccatccgcc ttcaaattgg 3359101 tgggcagcta aagcaccgcc ccataaaaaa tcctttggca tgtttcccat gtttaattcc 3359161 tcctcagctt acgactgtaa atattttttg atgtaatgca ctttcctcaa tgtcttcaat 3359221 gaaagcttta tcaaactcaa caagcacttc gccttttttg acggtatcgc cttcttttac 3359281 cttcaaggaa aaaggcgtgc cgtcaaatgt caccgtatcc agcccgatgt gcgcaagcaa 3359341 ttcgacgccg gacgctgaac gcaggccaat cgcatgcttt gtaggcgtaa ccatgacaac 3359401 cgtaatgacg ccgggatggt agcatcgatt tcacgatatc cttcgcttta ggggtagacc 3359461 gcttcagcac caatcgaagt ctggtagcgc agcgagaagc cccaatcaca ttctcttccc 3359521 cgcctacggc ctctaaaatg tcttttgcta gtctcgtata atctctcact ttccccgaca 3359581 tttcacccac cccttcgttt tggttacgct ttcattataa ttgtaacggt ataatttatc 3359641 aattccgaaa caaaatattt acgcactaac tatcattgta agcggtttat gctataattt 3359701 tgacaagtga aactaaacga ataaatgagg aatgcgtatg ttaaaatacc agcaaatcgc 3359761 aacggaaatt gaaacatata tagaagaaca ccagcttcag cagggagaca aactgccagt 3359821 cctagaaacc ctcatggccc agtttgaagt cagcaaaagc accatcacaa agtccctcga 3359881 gctattagag caaaaaggcg cgatctttca ggtcagagga agcggcattt tcgtcagaaa 3359941 acataaacga aaaggctata tcagccttct gtcgaatcag ggatttaaaa aagatctcga 3360001 ggatttcaac gtcacctcaa aagtcatcga actggacgtg agaaagccaa caccggaagc 3360061 ggcggaaaac ctgaacatcg gaatggacga ggacatctac tatgtcaaaa gggtccgcta 3360121 catcaacggc cagacccttt gctacgaaga atcctattac accaaatcca tcgtgacgta 3360181 tttaaacaac gaaatcgtct cccactccat cttccattac atccgggaag gactggggtt 3360241 gaagattggt ttttctgatt tgtttctgca cgtgggccag cttaatgagg aagaagcgga 3360301 atatttggga ttagaggctg gactgccgaa gctgtatata gaaagtattt ttcacctgac 3360361 aaatgggcag ccgtttgatt actcgaagat ttcgtataat tatgagcagt cgcagtttgt 3360421 ggtacaggct aatagttttt tattataggg ctcttcacta cggtaggtgg tcgacatgta 3360481 caaaattatc attcctgcca tactagccat ctttgcgctc tggatactct tacagatttc 3360541 actagagatg agcatcgtta agaatccaat gaactacttt atcgtattca ttatcttttt 3360601 cctctttgta aagatggtga aagaaaaaca ataatagttt gggcgatgca aacagaaaaa 3360661 catccttccc ttaacaaact cagccagtca catgcattaa tcttgatgtt aatgatatat 3360721 aggtgcacat aaaaagctac ttcattgtga agtagctccc tttattaaag gcccattttg 3360781 atccatctag ttttagaaaa gcgaaggaca atcgcattta tgataataat tgaaactaaa 3360841 tacaaaataa taaataaaac atcattactc ccaagtgtca tgttatcaga ttgcagcact 3360901 ctttctattc gggggtacat agtgttacct gcctcaaaag gagcaatgaa accaaacgtt 3360961 ttattgctta tagctactaa gataacagaa gtcatccaat aaacgatact gacacctata 3361021 ctaattaata tattaggaca taacacgctt atagttccga taattagaat atactgcagt 3361081 ataactgcag aaaataaaaa aagtaataat gcaaaatgcg aaaaatcatg gtacatcaac 3361141 gatatgatta gcaggcctag cgttataaat gcaaaacatt ctaaaaataa aacagctatc 3361201 tttttataaa agaaagtata gatgttctct ccaattaact tgtaaaagag aatatttttg 3361261 tttgaatact ctctattaat aaagaaagct ataacaaatg aaaataacat caaaccaaac 3361321 tgggtcgcaa cagtatagga gctaaagaaa aacatttcag gtgtaacatt actgacttta 3361381 tcgattccaa caagtaaaaa ataacccagc aaaaataaaa atacaaacat tgctcctaaa 3361441 ataatgataa ctttgttgct aatactcttt ttaaactcta atttcatctc aagcccccac 3361501 tgttttatta ctcatttata tacacttcaa ttaatttatc cactgaatga tattgttgaa 3361561 tttcttggtg attaaatata taataatccc cttctatcgc ctttaaatca gacaaatcat 3361621 gtgtaatgtt gatgataatc ttctcggggt tctcctgaat atacttgttt aagaagccat 3361681 gaatctctat aaccgttttt ttgtctaatg aattcgttat ttcatctaaa acaataatat 3361741 ttttatcctc taataagaaa ctgagcaatt ttaatttttg cttttgtcca tcactcaaat 3361801 ttttgatcag aacttttcca tcaatattat ccagattaag taaatatgcg attttatcta 3361861 tcatttttgc atcaaatttt ttactcaaaa agtgtaataa aaagtcctta gaaacatcat 3361921 taggtatatt cgacgagctg gatattaaag aaacattttg acgaatatct ctgccgattc 3361981 ttttgctatt attcaacaaa aagtctttag caagctgtga tttaccgact ccattttttc 3362041 cgacaacgtg attaattttc ccgctcgaaa aatgcaagtc ggtgtcctga agtaacgttt 3362101 tgcctttcac ttttaaagtg taattcgcta tattcatata catactccta ggaaatattt 3362161 gcataataat aaaatgttct gccttgtgat ttgttactaa tgtctaagct tttgaggtac 3362221 ctctttcgtt tccgatccgg aagcgaaaga aatgttttta gatggctaat ttggagatct 3362281 tttactctag tttacaatat ataatatcca atgtacaact gaattcactg caaggccaat 3362341 ccctataatt tgaatcgtaa gaactaacca atgatttgtc ttaaaacggc tatattcatc 3362401 taagctcaga aaagctaaaa gaattttgta accatcagaa ttcaatattg ggattaagtt 3362461 ccacaataaa gtagacgaga aaagcataaa tgccatagtt aatgcttcac tggaaaatgt 3362521 aaattgattt attaattcta atgtatttat taaaagataa ttgataaaca agccaaataa 3362581 atgaacgatt atcttttcat ttcttgatag catgtaggtt tcattcaatt ggacataaaa 3362641 agcaggaaat acataaaaat tcagtttgaa tcccacttta tcaaagtttt tcccgaaaaa 3362701 ttttaaggaa taaatatgtc ccagttcatg aagcactata ttcattataa aataaataac 3362761 tataattatc cacattttcc agccgtaaaa tactgaggac aatccatttt gcaattttat 3362821 taaatgaata taatttaata tgaacatgag agccgtaaag gataagaaca gataaaaaaa 3362881 ctttggtgat actttctctt tatacatttt aaaacgtaat aattgtttat ctgacagaga 3362941 atttaaacta tttttatagt attctccgct ttttttgtct tttataaata cgttgttttg 3363001 cacaagcact tcatattttt catcttcata ctttaaaatt ttcattatag tatttttcca 3363061 tataaggata gaagtagttt attttttctg cagagttgaa taaggaacca caaactccac 3363121 aaatagagga aaattcataa ggaatgtcaa attcctctat tttgttattt tcttttaaaa 3363181 tattcaaaaa ccatttgaat ccttcttttc taagaataaa taatagcaaa ttggaattta 3363241 acttttccac ggttctttcg aaactttggt tatattcttc ccttagggtt attttcgttt 3363301 caaaaatagc aggggaacaa catggataaa tttctccatc atgatgatat acaatgtcat 3363361 atccgggaca atgtaaggaa tcttcatctt caagactgta aaatttatgt atgttttctt 3363421 gcttaattct agttttagca gcgccaactg atatcattgg aaattttgtt atctttacac 3363481 ctaagattga atcccccaat tcctctaaaa tgtggttgga cattttgtct ttggtaactg 3363541 ccatattaag agaaatatcg atatcagggt atttcctgct atgttctaat atgtttttaa 3363601 tactggaaga cttgacaaat ggagcatggt actcatcata acttatagtc agtgctatca 3363661 catttaaaga attcatatca tgaaagtact cctggacctt tttcttgctc aaaccccaaa 3363721 atccattaga gatcaacgtt atttgttttt catatggttt aatgatttcc attagttctt 3363781 ttaaaaattt ataatctaaa aaaacttccc cacctgtaaa agaaatcact tgaatggttt 3363841 tgttttttgc aaattcagtt actaactctc ttatgtattc tttttccatc ctggttgttg 3363901 aagttggtga actagaaaaa caacaatggt cacaggatgc attacacctt gaatctaaat 3363961 tgattgatac tgttttatta tacatgaaat atcccccaac aaatggtaaa ggagagttag 3364021 actctccttt gtacccctct aattaatgac cacttccaag aatccagcga ttttcttttg 3364081 attttacaaa ataccaaaga tcattcactt ttgctaactt ttgtgattca tctaatagac 3364141 ccttaaattc taagtttttc acagtctcat tgttagtgat ttcctttttc atattatccc 3364201 tcctcctttt ctaatataaa ccaattattc tatatcattc aatacatgtc aatatattgt 3364261 acctaaaaaa tctgaaaaat gtcactattc ttggtatata aagcctatag tcctctagcc 3364321 cctctaagct ataccgaatg aaaggccata gtttgattta aagcttcgta atgaaaagta 3364381 aaacatcaat attgactaca ctagttaagg gatatacaga ttttaagtgg aagaaatgag 3364441 gcaaacaatc ttaccctaaa ccaacctgta ctgaaaagct gttttaagct cttgcttacc 3364501 ccatttggca cctctttctc tcgttttaat tgtctctaaa agcagttatg cggtactatc 3364561 atataaaggt ccaatgttta aaaataatgt catactttta aattcacctt atcatgcaca 3364621 tgctcataaa gaggggttta ttctaaaaag gggatggacg gttttggaaa gcaagtacct 3364681 agatctactc gcacaaaaat acgattgtga agaaaaagtg gtaacagaaa tcatcaattt 3364741 gaaagcgata ttgaacctgc caaaaggcac cgagcatttt gtcagtgatc tgcacggaga 3364801 gtatcaggca ttccagcacg tgttgcgcaa tggttcagga cgagtcaaag agaagatacg 3364861 cgacatcttc agcggtgtca tttacgatag agaaattgat gaattagcag cattggtcta 3364921 ttatccggaa gacaaactga aattaatcaa acatgacttt gatgcgaaag aagcgttaaa 3364981 cgagtggtat aaagaaacga ttcatcgaat gattaagctc gtttcatatt gctcctctaa 3365041 gtatacccgc tccaaattac gcaaagcact gcctgcccaa tttgcttata ttacggagga 3365101 gctgttatac aaaacagaac aagctggcaa caaggagcaa tattactccg aaatcattga 3365161 tcagatcatt gaacttggcc aagccgataa gctgatcacc ggccttgctt acagcgttca 3365221 gcgattggtg gtcgaccatc tgcatgtggt cggcgatatt tatgaccgcg gcccgcagcc 3365281 ggatagaatt atggaagaac tgatcaacta tcattctgtc gatattcagt ggggaaatca 3365341 cgatgtcctt tggatcggcg cctattccgg ttccaaagtg tgcctggcca atattatccg 3365401 catctgtgcc cgctacgaca acctggatat tattgaggac gtgtacggca tcaacctgag 3365461 accgctgctg aacctggccg aaaaatatta tgatgataat ccagcgttcc gtccaaaagc 3365521 agacgaaaac aggccagagg atgagattaa gcaaatcaca aaaatccatc aagcgattgc 3365581 catgatccaa ttcaagcttg agagcccgat tatcaagaga cggccgaact ttaatatgga 3365641 agagcggctg ttattagaga aaatagacta tgacaaaaat gaaatcacgc tgaacggaaa 3365701 aacatatcaa ctggaaaaca cctgctttgc gacgattaat ccggagcagc cagatcagct 3365761 attagaagaa gaagcagaag tcatagacaa gctgctattc tctgtccagc attccgaaaa 3365821 gctgggccgc catatgaatt ttatgatgaa aaaaggcagc ctttatttaa aatataacgg 3365881 caacctgttg attcacggct gtattccagt tgatgaaaac ggcaatatgg aaacgatgat 3365941 gattgaggat aaaccgtatg cgggccgtga gctgctcgat gtatttgaac gattcttgcg 3366001 ggaagccttt gcccacccgg aagaaaccga tgacctggcg acagatatgg cttggtattt 3366061 atggacaggc gaatactcct ccctcttcgg aaaacgcgcc atgacgacat ttgagcgcta 3366121 tttcatcaaa gagaaggaaa cgcataaaga gaagaaaaac ccgtattatt atttacgaga 3366181 agacgaggca acctgccgaa acatcctggc agaattcggc ctcaatccag atcacggcca 3366241 tatcatcaac ggccatacac ctgtaaaaga aatcgaagga gaagacccaa tcaaagcaaa 3366301 cggaaaaatg atcgtcatcg acggcggctt ctccaaagcc taccaatcca caacaggcat 3366361 cgccggctac acgctgctat acaactccta cggcatgcag ctcgtcgccc ataaacactt 3366421 caattccaag gcagaagtcc taagcaccgg aaccgacgtc ttaacggtca aacgattagt 3366481 ggacaaagag cttgagcgga agaaagtgaa ggaaacgaat gtgggtgagg aattgttgca 3366541 ggaagttgcg attttagaga gtttgcggga gtatcggtat atgaagtgag gggtgtgggg 3366601 ttcagggatg gtgatatgcg ctgagaaaat gattggataa atgaaaaacc cccgcgggat 3366661 gcgggggttc aatttaacga aagaatccta aaacggtttg tagttttagg attctttcat 3366721 cttttcagcg tgattgaaaa cccttgaagt ctaggaagaa cgagcattgg agcgcagcga 3366781 atgtttggaa ttcgtgagca ccgaagcgca ggcctgacaa cgaatgcgag ggtttgtcga 3366841 cacgctgaaa cccccgcggg tgcgggggtt ttcttattac agcagcttct tccctaacag 3366901 ggattctacg agctctactg ctgttttgcc cgttttgttt ttgtgatcaa ggatcgggtt 3366961 aacctcaacg aattcggctg aggtaatgat gcctgcgtca tacagcattt ccatagccaa 3367021 atggctctcc cggtagctga tgccgccgac gacaggggtt ccgacacccg gtgcgtcgtt 3367081 cggatcaagt ccgtccagat caaggctcag atggacgcca tcacatgctg ataaataatc 3367141 aagggtttct tcaatgacct ttgtcatgcc aagacgatcg atttcgtgca ttgtgtacac 3367201 cttcatgccg ctttccttaa tgtacttgcg ctccccttca tcaagtgacc gggcgccaat 3367261 gatgacgacg ttttccggtt tgattttagg cgcgtagcct tcaaggttaa ccagtgactc 3367321 gtggccaatg cctaggctga ccgcgagcgg catgccgtga atattgcccg atggtgaagt 3367381 ttcaagtgta ttcaaatcgc cgtgcgcgtc ataccagatg acgccgagat tatcgtaatg 3367441 cttcgctgtg cctgcaagcg tgccgatcgc aatactgtgg tcaccgccca ggacaagcgg 3367501 gaattttttc tcttcaatga ctttgttgac cttttgcgcg agtttttcat ttcccgccaa 3367561 aacggaattc aggtttttca gttcctcgtc atttttgatt ttttcgcgat tgatcggaat 3367621 gtcaccgaga tcttcaaccg tataccccat gtctgacagc ctctcgatca gatgagcgta 3367681 ccggatggca ctcgggccca tatccactcc gcgtcgtgct tgtcctaaat ccattggcat 3367741 tccaataacc gaaatcgttt tatccatctg tgattccacc tcaacattta agataatgtc 3367801 ctatgcgggt tataacaaag atgacttgcg gacaacgttt ttaaagctct agctgacgat 3367861 ttgcctgctg gcgtttttta atgacgacat gataaatgat gtagcaaatg atcataaacg 3367921 gtacgccgca atacagcgcg atacgctgct ccggatcaaa tgcaagactg atgagcacga 3367981 ccgtatttaa cgttaggccg atcagcggaa gcaccgggta cagcggtgtt ttaaatttca 3368041 aatcttctat cttcccgccc tcacggatat atttgcgtct gaacatgatt tgggaaagcg 3368101 agatcgtaat ccagccgacc tgcgcgctca tgcccgccaa agataacagt accatatata 3368161 cggtttcagc ctgcgcaaac tttgtcagaa gtgataggca ggccacagcc atcgttacga 3368221 ttaacgagta catcggtaca ccgcgctgat ttgttttgcc aagcgctttg aaggcttgtc 3368281 cttcattcgc catcgcgtac agaatacgtg ttgatgcgta taaacctgag ttcgcaacag 3368341 ataacagtgc gattaaaata acaaagttca tgatatcagc tgcatatggg attccgattt 3368401 gctcaaatac ggcaacaaat ggactttcca cgacacccgc ctgtttccac ggaatcatgc 3368461 cggcaatgac aatgattgaa agcacaaaga acacaagcgt tctccatact gtctgtttga 3368521 tggaccgcgg aatcgttttt tcagggtctt cactttctcc ggctgcaacc ccgatcagct 3368581 cagtcccctg aaacgcaaag ttcacagtaa tcatcgtaat cagcattgcc tttatgccgt 3368641 tcggaaataa cccgtcttca taaaaatgtg tcaaaaacgg cgcctgctct ccgcccttca 3368701 gatcaatcag gccaaacatg gcagctccgc cgagaataat aaataaaagg ataatcaaaa 3368761 ttttaatgcc tgagaaccag aattcagatt ccgcaaaggc ttttgtggtg atcgcattta 3368821 aaataaacat cagtgccgca aagaccagac accagatcca cacgtctata tgcggaaacc 3368881 agcgttgcat cagctgcccc gctgataaaa attcaatggc gcatgtaacc gcccagccga 3368941 gccagtacag ccagccgaac gcaaacccga aggccgggct gataaatttc gtggcatagg 3369001 tctggaagga ccccgacaca ggaaaggcga ctgccagctc tcctaagcag agcatggtca 3369061 aaaacatgat aaagccgccc actaaatagg acagaaccgc gccgagcggt cccgcttggt 3369121 taatggtaaa cccggttcca aggaagaaac cggttccgat cactccgccc aatgaaatca 3369181 tgaacaaatg gcgtgatttc attgtccgct ggagctgatt tccgttatct tggtttgtat 3369241 tcacattctg caccccttca gcaacttgta ttggatctaa gctggaacat ctgcatggtg 3369301 ctatcccagt ttgctgtcca aagagtctct atctatttaa tataaaattc acttcttctc 3369361 ataaagatac attatactaa aatactgtag ctgagcaaat agggagtgct gatttttctg 3369421 ttgtaaattt atacaaacga agtgaatatc ccgccatggt gcggatttat gcgtttcgca 3369481 gcacgtgctt aattttctct atcgcccaat ccaagtcctc tttggaaatg attaatggcg 3369541 gtgcaaaacg aatgactgta tcatgcgttt ccttgcataa aagtccctct tccttcaaac 3369601 gctcacaata cggacgtgcc gcttcagtca attccacacc gataaacagc cctctgccgc 3369661 ggacttcttt aatgacaggg ctgtcaatac tctcaagctc gcttttaaag tattcaccaa 3369721 gttcaagaga acgatccgcc agcttttcat cctccagcac ttctaatgaa gcgatagaca 3369781 ctgcacatgc aagcgggttt ccaccaaatg ttgagccgtg tgagccaggg ttaaacacgc 3369841 ctaggatctc gcggtccgcc gcaatgcaag agatcgggaa cacaccgccg ccaagcgctt 3369901 tgcccaagat atacatatcc ggaacaatgc cgtcccagtc acaggcaaac gtcttgcctg 3369961 tacgtccgag acccgtctga atttcatccg caataaacaa gacattctct tccttacaaa 3370021 tcgccgccgc ttcctgtaaa aatccttcag gcggaatcac aatgcccgct tcgccttgaa 3370081 tcggttcaaa caagaatgcc gctgtattcg gcgtaatggc ctgtcgaagc gcttccacat 3370141 cgccgtaagg aatgagtttg attcctggaa gcatcgggcc gaatcctcgt ttatattcct 3370201 cttcagaaga aagagatacc gccagcatcg tgcggccgtg gaagttcccg acacatgcga 3370261 taatttccgc ttgattgtca gctacgccct tcacttcata cgcccagcgt ctcgccgctt 3370321 tcaccgcgga ttcaaccgct tcggctcctg tattcatcgg cagaatcatc tctttgcctg 3370381 tcagtttagc tgttttttcg taaaacggcc caagctgatc gttatgaaac gcgcgtgacg 3370441 tgagggtgat tttatcagcc tgatccttta atgcctgaat gattttcggg tgtctgtgcc 3370501 cctggtttac cgcagagtaa gcactcagca tatccatata ttcattgcct tccgggtcct 3370561 ttacccaagc acccagcgct tcagaaataa caatcgggag cgggtgataa ttgttggctc 3370621 cgtaatgaga cgtctgatca ataatttctt tggatttaga taaagctgtc atatttgaat 3370681 tcccccttgt tttctgtttc aacatgttat cctgctttcc ctttatataa atgcaagttc 3370741 tgtgccaaat caagaattcg tgtgttttct acaattttcg aggacaaggt gcaaaaacat 3370801 tctgatattt cgagcgaaaa tttcagcaag tgcaaaattc ttttgcatat cctctccgtt 3370861 tttttataaa atagaagcaa tattaagaaa ataattgagg gaggttcata cagtggtcaa 3370921 agacagcgaa ttcctcacat tggtttttca gagtatttta gatgaaatcg atgttggcct 3370981 gcacgtggta gacgagcatg gaaacacaat cgtttataac aataaaatga tgcagattga 3371041 agatatggag aagcatgacg tcttgaataa aaacctgatg gatgtgttta tgttttcaaa 3371101 gcagcaggac agcacactgg tacaggctct tcaggaaggc aagacgatta aaaacgtcaa 3371161 acagagctat ttcaataata aaggccagga aattacgacg atcaatcata catatcccat 3371221 cgtccaagac ggcaaaatca ggggcgccgt tgaaattgcc aaggatgtga caaagctgga 3371281 acggctgatc agggagaata tgaacaaaaa aggcagcaca acctatacgt ttgacagtat 3371341 tctcggcacc agtccggcca ttcaagacgt catcgaaaac gccaagcggg caacccgtac 3371401 gtcatcatct gtccttctag caggcgaaac cggcacggga aaagaactgt tcgcgcaaag 3371461 tatccataat ggaagcgatc gttctggcgg cccgtttatt tcgcaaaact gcgcggcact 3371521 gccagacagc cttgtggaaa gcattttgtt tgggacgaaa aaaggcgcgt ttaccggcgc 3371581 tgtcgaccag cccggcctgt ttgaacaagc ccacggcggc acactgctgt tagatgaaat 3371641 caactcgctg aatctcagcc ttcaggcgaa gctgctgcgc gcccttcaag aacggaaaat 3371701 caggcgcatc ggttcaacaa aggatacacc gattgacgta cgtattattg ccacgatgaa 3371761 tgaagaccca attgatgcaa ttgcaggcga acgaatgcgg aaggacttgt attacaggct 3371821 gagtgtcgtc acactgatca tcccgccgct tcgggaacga aaagaagaca ttttgcttct 3371881 cgcgtcggag ttcatccaga aaaacaacca tctgttccaa atgaatgttg aacacatcag 3371941 cgatgacgtg aagcaatttt tcctttctta tgactggccg ggaaatattc gcgagcttga 3372001 gcatatgatc gaaggcgcaa tgaatttcat gacggacgag caaacgatta cggcttccca 3372061 tctgccctat caataccgca tgaaaatcaa gccggctgac atcccagagc cggaaacacc 3372121 aagacaccag ccagccgcgg acttaaaaga aaaaatggaa agcttcgaaa aatatgtgat 3372181 agagaacgtg ttaagaaaac acggccataa catctcgaaa gctgctcagg agcttggcat 3372241 cagcagacaa agcctccaat atcggctgaa gaaattttct cactcgtcta acgaataatc 3372301 cggagcagga agcctgatca gaaaaacagt gcctctgccg atttcacttt tcacttcaat 3372361 cgtcccattg tgattgtcga taatcgattt cgttatggca aggcctaatc ccgaacctcc 3372421 atatttccgg gagcgggatg ggtctgcctt gtaaaaccgg tcaaacacta aaaaacgtca 3372481 cttcttatgc attgaagaaa gaaaatggca cctatgtgta tcacagccag caaccacacg 3372541 gtacaaacca ttaaagtcca tgcaaataac ggaagtattt gcagctaact gccatttgct 3372601 gtttcacgtg taacatccat cttgtatttt tcttcatatt cgatatatcc tttttcaact 3372661 gaacgggcgt gacccctgtt cagttttttt tgcatatcaa aacagcctgg caacgatgcc 3372721 agactgcttt tattaactgc ctaattggtc tgcggaggac agcttgatat caacagattt 3372781 ttcttttccg ccgcgataaa acttcacctt cacccggtca ccgacttttt tctgataaag 3372841 ccgttttcgc aggtcaacaa tatcatttac tttgtatccg tcaaattccg tgatgacatc 3372901 cagttccttc agccccgctt ttccggcagg tgaaaaggcg tctacaccca tcacaaccgc 3372961 tccattggtg acgttcttag gaagctttaa tgtttcatcc caatgatagc ttgcgatgtc 3373021 acttagcgat ttcatctcaa tgccaaggaa cgggcgtttg acctttccgt atctctctaa 3373081 atcctctatc acagggatca cgagcttaga cggaatggac aggccaatcc cttcaaccgc 3373141 tgactcggca attttcattg aattgatgcc aatgaccttc ccatccatat ttaacaaagc 3373201 gccgccgctg ttcccagggt taatggccgc atctgtttgc aggacttcag cgttccagtc 3373261 aggctgtcca tcaccgtttg aatctactgg gatcgccctc tccgtacccg agatgacgcc 3373321 ttgtgtgaca gagcctgcaa actcaaggcc taacgggttc ccgatcgcaa taaccggctc 3373381 cccagacttc actttatctg aatttccgaa atcagcgact gctttaatct tatcgctttt 3373441 cacccgtaaa acggcaaggt ccatcagctg gtcgctgccg acaagatcag ctgatacacg 3373501 tgagccgtct ttcaagctga tttcaatttg ggaagcgcct tcgatgacat gatggttggt 3373561 cacgacataa gcggaatggt catttttctt atagatgacg ccagagccgc tcccagcctc 3373621 gccgctctct ccccaaatat ctgatttttg gatgttcaca acaccgacaa cggcgggcga 3373681 catattgctg acaatcttgg tgacggcatt gttgacactg acattcaccg tcctgattga 3373741 ttcccggcca ttgttgtttt gctgctgatc taaggcgcct gtatccagcc cttcatttga 3373801 aaggtacggc atgataaacg ccattaatac ggcaccgaca atcacgccaa tcagactcga 3373861 aagaaaatat ccttttttgc ttctctttgg ctgttcagga gtagtatgtt cttcctcacg 3373921 ttcgtaatcc accatattcc atcctttcca agaacgttaa tatggttata ttgtgggtta 3373981 gaaactccta gaatagtcat gatttacata gaaaaattat acagcgcaaa gcggagtggc 3374041 cttcttcgga tcggtgtcgt ataagtcaaa tgtctcaccc gtcacaaatc ctttagaagc 3374101 caatgtctgc tgcacagaca ttcttgccag ctccttcatg ttgttgtcct ggctcaaatg 3374161 cgccaggtaa atacgagacg tctcatcgcc aatgacatcc gtcatcgcca aggcagcatc 3374221 ttcatttgac acgtgcccga cgtcacttaa aatccgccgc ttaatgctcc atgggtatct 3374281 tcccatttgc agcataccga catcgtgatt gctttcaaac acaaatacat tcgctgaacg 3374341 gataatgcct ttcatccggt cgctgacata tcccgtatct gtcattaacg cgagctttcg 3374401 gccgctataa tggaatacat aaaacatcgg ttccgccgca tcgtgggaaa cgccaaacga 3374461 ttcaacatca agtccgccga acgacttcac cgtctccatt ggaaatacaa acttttgatc 3374521 ggtgtcaatt ttgccgattt gattctccat cgctttccaa gtcttctcat tcgcatagat 3374581 cggaagcttg tactttctgg cgacgacacc aaggccctta atatggtcac tatgctcatg 3374641 cgtcacaaaa atgccgtcta catcatccag cttacgcccg atctgcgcca tcagcccatc 3374701 catggctttt ccgctcaaac cggcgtccac taaaaatgcg tgatcctctg tttcgaggta 3374761 aaacgcattt cccgtactcc cgctcgcaag tacgctaaat tgcaagctca tgtttgtctc 3374821 actccattat tttcattgat ctgtatctaa aatcgtactc tccaaagcat tcacagtaaa 3374881 atactcttgt actgtctttt tctcaccgtt cacttttttc tcgtactcga ccgtaattct 3374941 ccataccggc gccagcacct gcgtacttgt cagcggatat tgtgctacat agccgaattt 3375001 acagctcttc acagtgctgt attcttttaa ttgattttga tagtacaata gctcaaccgc 3375061 atccatttca gtaattaagc tttctttctg gatttgcttg aaggtctcaa gcgtagtctg 3375121 gtcgtatgac acaacctcgt ttttaccgtt taagtgcagc accacttgcc cgatcatatt 3375181 agagggattg tcggtctttt ggtaaatata atgaccttcg tacgtttgga agaaaataat 3375241 ttctttcttc gatttatcaa ccttccaaag cttatatttt tcgccatctt gaattttcga 3375301 agaaacaagt gcctgagcat cgtcctcgat atccttcttt gatagtgcga ttggatttgc 3375361 aaacttcatt ttcaggctcg ttactttatg atcatcacta ggcatgtcca tcaaaggctt 3375421 ttgatccttc agcgcctcaa tttcctcctt ggagaaagac ttttgatttg ccgtgatccg 3375481 atagccttct gttgcttcct tattcaagcc ttcatacgtg atatgatcgg ccttcatgtc 3375541 atgctcgaca tcatttttaa tgacttcata ttctttgccg gtagcctgcc atttttgaaa 3375601 aaactgatag cctaagaaaa tatctaaaat gaggaaggca acgatgaaga ttgattttgt 3375661 cttattccac tccactgtta gccccctcct tcctcaataa atcctttgta atcggcacaa 3375721 tttttccatt tactttcatc gcccaaaccg gttccagttc aacgagagga tcatcgttgg 3375781 ttgatgttga taccaattga taagcaagga agatctgatc aattttgtcc gtatcataag 3375841 cggtttgttt cgaaagcagc atcttcactt cgctgccgcc catgagctct gtttcacttg 3375901 ttttaatcgg attcgttccg agactgtaat tcggccgctt atagctgaga atatcatcat 3375961 tcgcccattg caccgtaatc gccgatgtcg ccccgaaagg tttggcggtg ctgttaatga 3376021 ccgggatctg atccataaaa atatagaagc tcaactgctg gctgtcattg atattgaaaa 3376081 attgatagtg atccgtccag cttccggtat cctcaaggta tttttggctc tttttgatta 3376141 attcacctgt ttgataggat gtgctctgca ccaaattgcg ctgctgaaat tgcacctgtc 3376201 tctggcttag attcacatct aaccggctga tcccatctgt cagcacattt ctgttggtgt 3376261 aattcgaatc ttctcttaca atgctcggat cactaaacaa agcctgctta aaggtatttg 3376321 ttttaatcga ttctgtgaca aattcttttt tgtccatcgt aagcggtttg ttcggcagca 3376381 agaactcttt ctttgagcca atggagaaca aactgaacgc cggcatattt gattgcctgt 3376441 ttttcaagtc gttcataatg ttccggtagt ttgctgattc aaccgtcact tcaagaatga 3376501 gctgcttgct gtatgacacc aaatagattt tcttgttcgc ttttgtttca ttgaacggga 3376561 tcagaatatg gtcaaacgaa ctgtattcaa acgactgatt agaccattta aacagcgttt 3376621 ggaaaatatc aatcgggatc gtatcgctga attgcaagtc aagcttggct tcagaaccgc 3376681 ctattccata aaaccagctt ttgaatccag ccttgtcata ctgatccgaa atatctttaa 3376741 ttcctttcac atcccaatgc ggcaagtcag accaaatttc ttcatagagg gcattgtcat 3376801 ccactttgta atgagcgccg tcatcatgga taaacatgtc ccttggcctt accgtttcag 3376861 acagcttttg ggtggttttt tcgattttat gtttcacacg aacagtagac tctgttgagg 3376921 atgagccttc agaaaagttt ggctggaacg tccatatccc ccatgtaaaa acaagactga 3376981 tgacgacgag taccgtaagt aatatcgttt ttatattttc acgcttcatc ccaatcatcc 3377041 tcttgttcct ctttatatgg aagagtaaat gtaatcgtcg tgccttttcc ttctatgctg 3377101 tccgcccaaa tatctccacc gtgcgcctgt accatttcct tggcaatcgc caatcccaga 3377161 ccggtgccgc caagctttct cgttctcgct ttatccaccc tgtagaagcg gtcaaagact 3377221 ttttcgacat cttttttcgg aatgccgatc ccttcatcct tcacgctgat atagagaagt 3377281 tcttcctctt cattgacatc aatcgagaac gtgacatgtc cgccttccgg tgaatatttt 3377341 aaagcgttag aaataatatt atcgagcacc tgcgttattt tatcctggtc aatctcgaca 3377401 tacagatctc tgtccggcag attgcggata aactccacat gctgctcttt tgtcatttca 3377461 aaacggtcaa taataagtga cataaaccgg acaatctgaa tccattcccg gttaaattga 3377521 taatctttac tgtcaaattt cgacagctga agcagatcat tgacaagccg gatcatacgc 3377581 tctgtttcat tttgcgtcac cattaagaag cgcggagcaa tgtctttatt ttcccacgcg 3377641 ccttcagcta acgcttctaa atagctgcgc attgtcgtaa gcggcgtccg cagctcatgt 3377701 gatacattcg caacgaattc tctgcgttcc tgatccattt tctcttgttc ggttacatcg 3377761 taaatgacag cgattaaacc atcaattttg ccgtgttccc tttgaatcac agagaaattc 3377821 acgcgaagca ccgttaattc atcatcgcgc tcaatttcaa gcagcataga atcctgctgt 3377881 tccactaaat cttcaaaagt ataattctct tgaagcccca gcaaactcgt aatcggcatt 3377941 tctaaggctg tttcacgtga aacgttcaac agttccagcg ccgggctgtt taagagaata 3378001 atcgctccgt ttcggtttgt ggcgataacg ccgtctgtca tataagcaat gacagaggct 3378061 agctttctgc gttctccttc agtcatcgcc tgggcatctt caagctctct cgttaagtgg 3378121 ttaaacgttg tggccagctg cccaatttca tcatgtccat actttttaac cttcctcgag 3378181 aaattccctt tcgcaagctc catcgcctgc tttcgcatat ctgaaagcgg gtgggtaatg 3378241 gttcttgcca gaaaaatacc gagaagagcc gtcaaaacaa gtgccaaacc tgtgccggac 3378301 gccagtatcg tgttgatcgt cttcatttga ttaaagacat cttccatact cgcgacaacg 3378361 tagatcgcgc ccacaacctc ttggttttca gtcatgacgg gcttcgcgga aataagaact 3378421 ctgattttgc ttttcgggtc ataatatttt cttaaatacg actgtttggt agaaaagatt 3378481 cttttgaaaa tcagatcggt cgtttgtttc ccagccactt cctcaccgta cggctttgaa 3378541 gaaccgacca cttcatagct tttatctaca aagctaattt cccgaacctc atcacttttc 3378601 gtgaagtcat tcaaaatacg gctgacgtca tcctttatga cggtactgtc gttatcgctc 3378661 ttatattctt gttcgatata ataagaaagg ttgtcgattc gctgattcag cgattgttca 3378721 taagagctga tcagcgactt ctctacctga ttgacaaaat acacaccaat gatttgcatg 3378781 gcaatgataa tcaaaagcac ataaatcaag gtaatcttaa attggatcga ccgaaaaaaa 3378841 ccaaccttat tcatatgggc attagtcctg ttctgggttt ctcaagtaat aacctacacc 3378901 acggcgtgtg acgatccaat ttggatggct cgggttgtcc tcgatttttt cacgaagccg 3378961 gcggactgtt acgtcaaccg ttctgacatc gccgaagtaa tcatagcccc aaacggtttg 3379021 aagcaaatgt tcacgggtca tcacttgtcc gatatgtttt gctaaataat gaagcaattc 3379081 gaactcacga tgagtcaatt cgattgtttc gtctcgtttt gatacaacgt acgcgtcagg 3379141 gaagatgacg agagagccga tatgaatctc gttagaggaa ggctcttcct ccgcaggcgc 3379201 tgttgtcagc tggcggcgca ggttcgcttt tacacgcgcc aagagctcgc gtgtgctgaa 3379261 tggttttgtg acatagtcat cagcaccgat ttcaagcccg ataaccttgt caatttctga 3379321 atccttagcc gtcagcataa tgattggcat atcgtatttc tttctgactt cgcggcatac 3379381 ttcaacgccg tctttatttg ggagcataat atctaaaaga attaaatcag gctgaagctc 3379441 ttctaccatt tcaacggctt cgtttccgtc gtgggcacag tgcacttcat agccttcttt 3379501 tcttaagtta aattccaata tatctgcaat cggtttttca tcatctacta caaggatctt 3379561 tttatccatc attttgattt tcctcctgcc gaatgacttc atttcatcta tataacattc 3379621 gtttcatcac ttatggccca tgtaaagaat gggtccttgt ctattataac ggtttaaggt 3379681 caaaagataa aaaaaataaa ggtttagaaa aaaaacacat gtttcacctt tatcgccagt 3379741 tgtttatcta ttgtcatgct ggtcaacttt ttttaaaaaa gataacttta ttgaaacctc 3379801 ccctcaccgg agtgcgtctt tatcaatgac gtcttcttct ttgaaccggc cgcagggccg 3379861 gttctccctt tttcttctat tataacactc ctcatgtttg cctttttcct aaaagaaaaa 3379921 acgcacctac gattgcagat gcgtttggta agtggctcgg gacggaatcg aaccgccgac 3379981 acacggattt tcagtccgtt gctctaccaa ctgagctacc gagccaaatg ttttattttt 3380041 ctctactaag taaagtaaaa tggcggtccg gacgggactc gaacccgcga cctcctgcgt 3380101 gacaggcagg cattctaacc aactgaacta ccggacctta cagtaattgc ccggagagct 3380161 gtcgtgtcag ctctcacaga caaataagga atttagcaat aacgctaaag taaatcaatg 3380221 acccgtacgg gattcgaacc cgtgttaccg ccgtgaaagg gcggtgtctt aaccgcttga 3380281 ccaacgggcc ttcacgaaat ggtgagccat gaaggactcg aaccttcgac cctctgatta 3380341 aaagtcagat gctctaccaa ctgagctaat ggctcttaaa gatgtcggaa tttctataga 3380401 gcaaacgact taaatctagt tctcatcttg tactctattg aagcagtttc cgtaacaacg 3380461 agatttataa tatcacgaac aaatagaagt ggcaataact tttttggttt tttttcatat 3380521 ttttttctca gaccaactta tatgcggctt tcaaacaaaa aacaagcccc ttaaataggg 3380581 gcttgcagac atattctatt tagttcgcac ggtacacact gcgaaggaca tttgtttgtg 3380641 agcggtctgg accgacagag aaaatagaaa gcggaatgcc tgtcagctga gacacacgct 3380701 caagataatg gcgcgcattt tccggaagct cgctcaagct cttcgcacct gtaatatcct 3380761 cagtccagcc cggcatttct tcatataccg gctcacattc agcaagtgcc ttaagacttg 3380821 ctgggaattc ttcaatgatt tcgcctttgt agcggtacgc cacacagatt ttcaacgttt 3380881 caattcctgc taggacgtca attgagttca gagaaagatc tgtaattccg ctcacacggc 3380941 gggcgtggcg gacaacaacg ctgtcaaacc agccgacacg gcgcgggcgg cctgttgttg 3381001 ttccatattc gcgtccgact tcacggattt gatcgccgat ttcatctttc agctcagtcg 3381061 gaaaaggacc gtcgccgaca cgagtcgtat atgcttttga tacaccgaca acgtgcttga 3381121 ttttggtcgg gccgacacca gaaccgatcg tgacaccgcc ggcaaccggg ttagatgacg 3381181 taacaaacgg gtatgttcct tggtcgatat cgagcataac cccttgtgcg ccttcaaata 3381241 atacacggcg cccttcatca agagcatcgt ttaagacaac agatgtatcg caaacatact 3381301 ttttaatctg ctgtccgtac tcataatatt cgtctaagat atcctcaagt ttaaaccctt 3381361 ctgtctcgta cattttctcg agaagacggt ttttttcttc aagattgcgc tcaagctttt 3381421 ccgcaaacgc gtcacggtct aacagatccg cgatgcgaat tccgatgcgg gctgctttat 3381481 ccatgtaagc agggccgatt ccttttttcg ttgtgccgat cttgttagcc cctttacgct 3381541 cttcttccac ttcatccaat ttcaaatgat acggcagaat gacgtgagct ctgttgctga 3381601 ttctcaggtt atctgtactc acgttgcgct catgaagata cgcaagctct gtgactaatg 3381661 ctttcggatc tacaaccatt ccgtttccga ttacacacgt tttatcctta tagaaaattc 3381721 cagacgggat taagtgaagc ttatatgtga ttccgtcaaa cttgattgta tgccctgcgt 3381781 tatttccgcc ttgataacgg gcgatcactt ctgcattttc tgataggaaa tctgtaattt 3381841 taccttttcc ttcatcgccc cattgcgtac ctactacaac tactgaagac atgtccgtgc 3381901 acctccgtta acctttcaaa acgattctat tcaaacaaat caagtttatc agtgaagaaa 3381961 cagaaagtca attgtaaatc cgaacattaa tttattgtaa atctatattc gttcgcttcc 3382021 attcgtttta taagcgtttt ctcactgctt tgtcataaaa agcttgcgaa actttcatcc 3382081 tttagcataa gaaagaatca cttgcctgat atcccttttg aattcataaa aacgatccgc 3382141 cagccgtccg ggtcctctat cgtcacgccc ccattgctcc agtacgggtt ctctgattcg 3382201 acctcttgat agcccatgtg ctttagcttt gaagtgatcg ctgccagttc aactgcattc 3382261 ggcacataaa aaacaagaag gctgtcggga tggggaacgg gggcagtgct tcccccttca 3382321 tactgggtga attccaaatg ataatcggca tgaggaaggc cgaacatgac accgtcatac 3382381 ccgttatgct gtgaaaattc tcctattcgt ttcaaacaca gtccctcttc gtaaaaacga 3382441 ataatctcat caagctggcc cgtaggacgc gcaattcgga tttgtgctgc ttgaaaagac 3382501 gaaaaacgtt ttcccatatt gttaccatct cctttttgca ccattttatt aaaacgcttt 3382561 caatttttca tccgctgagc gaacgtcatt tcttccatct ttcgaatgaa aaaaacccca 3382621 agagcagctc ttggggctta tgcgccgggc ggaacgcctg cgtcatcaaa acgccgttcc 3382681 aggttgacga atttgttgta ttcttttacg aacgcaagag acacggttcc taccgggccg 3382741 ttacgctgtt tggcgataat aatttcgata atatttttat tctcggtttc tttgtcatag 3382801 tagtcatcac gataaaggaa cgcgacaata tccgcgtcct gctcgatact tcctgattcc 3382861 cggatatcag acatcatcgg acgtttatcc tgacgctgct caacacccct ggaaagctga 3382921 gaaagcgcga taacagggac ttgcagctcc ctcgcaatcg acttcagttc acgggaaatt 3382981 tcagatactt cctgctgacg gttgtccttt gaacgaccgc ttccctgaat caattgcagg 3383041 taatcgatca aaatcatgcc cagcccgctt tcctgcttca agcggcggca cttggcacgg 3383101 atttcactca ctcgaatacc cggtgtatca tcgatgtaaa tcccgctgtt cgataggctt 3383161 cccattgcca tcgtcagctt gccccaatcc tcttcggtca ggttacctgt acggagattc 3383221 tgggcattga tatttccctc ggcacagagc atacgcataa cgagctgctc ggcacccatc 3383281 tcaagactga aaatcgctac gctctcatcg gtcttcgtcg ccacgttttg tgcgatgttc 3383341 agggcaaagg ctgttttccc tactgaagga cgggcagcca caatgatcaa gtcgttgcgc 3383401 tggaaacccg cagtcatccg gtcaagctcc gtaaaccctg ttggaattcc cgtgatatca 3383461 ccttttcgat tgtgaagctg ttcgatatta tcataggtct ggacaaggac gtccttaata 3383521 ttttggaagg cactcgtgtt tttgcgctgt gccacttcca taatcgtttt ttccgcttca 3383581 ctgagtaaat cctcgacctc atcctcacgg gtatacccgt cttgagcaat cgttgtcgca 3383641 gttctgatta atcggcgaag aatcgatttt tcctcaacga ttttcgcgta atattctatg 3383701 ttagccgctg tcggcaccga gtttgcgata tctgtcaaat atgaaatacc gcctacttct 3383761 tccagcaggt ctgtgttcgc aagctctgat gtaactgtca ccagatcaac cggttcacct 3383821 cggtcaccga gcaccagcat cgcattatag attttttggt gggacattct atagaaatca 3383881 tctggaatca atacttctga agccagtgtt aaagcagacg gctgtaaaaa aatagcgcct 3383941 aacacggctt gttcggcttc tatattttgc ggaggaagcc ggtcattcag aaggtctgtc 3384001 atgctaagca ccgtcctctc attaaaaaat ctccaacctc cattctacca tttctacaga 3384061 aaaaaaatag aaaaattgtc tgtttcctgt ttttttcagt tagcagattg gatcgtttcg 3384121 gacagtaaca aggcgggaaa aatgcaataa aacataaggg aggaatgaaa gatgataaag 3384181 aaatatgcga ttacacctaa tgttgatgcg gacggctggt ttattgaggt ggagaatgta 3384241 gcgccgacag ctttgtatac gtctaaagac gccgctattg aaaaggccaa acaggtggct 3384301 aaggaaaaca gtccgtctaa gcttgtaatt tatgaccagt ttaaaaatgt ggaagaagaa 3384361 cactcatttt aatgaatgaa agccttcgct gcagcgaggg ttttttagcg gttatcggtt 3384421 tatttcatcc attggatgcc tatgtgcatc atcaaatctg ccgctttttg atacagatcc 3384481 cactccccga tcgaagcaaa tttccccatc agctcctgaa gctttaacct cattgctata 3384541 tattcttcga aagtgacagc tttttcagtg tctatttggt gttccttcag catttgtttt 3384601 aataaggata acggtgcgtg cataagaacc ctccttacct cttttataac ggtcattttc 3384661 cgattgctct attcctttgt gacatcttct tacatttcac atctgattct tgtacaatgg 3384721 acagaagaga ggagggatct tttgtgagac ctttgcaaat ttctgccgaa actgcacaaa 3384781 agcttgcaga gtccttgaat ctgccgcttg aacagatcat gcatatgcct cagcatattc 3384841 tgcttgccaa aatggctgaa ctgcaaaaag aggacaaatc atagccttca ttcacatact 3384901 tgcttacctg tttcgggata atatcatgta tatgttagaa aagaggagta actgctttgc 3384961 cacatccaca taataaaaaa atccaatcat tttggctgat caccggcatt atctttatcg 3385021 cctttaactt acggcccgcg atcacttcag tcggtccggt catcagctct atccgggcag 3385081 agctgcacat gtccaatggg gcagccggtt ttttgaccgc actgccgctg ctttcgtttg 3385141 cagttctttc tccgcttgca cctaagcttg gacagcgcct cggtaatgag cgaactttat 3385201 ggctaggtct cgtgatactg ctgatcggtg ttctgactcg ttctaccggc tatactgccg 3385261 ctttgttttt cggaacagca cttatcggcg tcgggattgc gattggtaac gtacttttgc 3385321 caagcttaat caaacataaa taccctgaaa agccagggat catgatcagc ctgtatacga 3385381 catcaatgaa tatattcgca gctttagcat cgggtgtcag cgttccttta gcgacccaga 3385441 tgaatggcgg atggaaacaa gcctttctct tatggggcgg gctggcttta cttgcattgc 3385501 taatctggat acctcagctg cgccatcgag atacggcaaa ccagacaatg aagctgcaat 3385561 ccagttccat ttgggcttcc aaaatggcat ggtatgtcac catctttatg ggcctgcaat 3385621 cgtttttatt ttacagcagc atcgcttggt ttcctgaaat tctccgttca cacgggattg 3385681 atacggcaac agccggatgg atggtatcac tcatgcaatt tgcgagtctg ccttccactt 3385741 ttctgacgcc agttttagct gaccgtgtga aacagcagcg cggtatcgtt gcggcgctgg 3385801 cctcagttta tctgatcggc ctttgcggat tattagcggg cggaagccat acattgcttg 3385861 ccatctggat gatcattatc ggtatcggac aaggctccag cattagtctg gcccttactt 3385921 tgattggtct ccgcagtgaa aatgcccaac aggccgctgc gctgtcaggc atgtctcagt 3385981 cattcggcta cctgctggca gcagtcgggc caatctttgt cggctatctc tttgaccaga 3386041 cgcattcttg gacgatgccg attgtgcttc tcattgctgc cctgatcgta atgggagcag 3386101 ccggacaggg agccggacga gatcgataca ttttccagtc agaaaaacaa agaaattcag 3386161 cataaagcgg ggaagatatc tccgcttttt tctttgaata tttatggttt attcataagt 3386221 ttttcatatt tgttttttac aatgagacac cataaagagg tgaaaaacga tgaaaaccaa 3386281 acgattcgac gcagccctta ttcttatttt gctagcagca gcttttttga atacgtatca 3386341 catttggcag gatgatacag caaaccagta ctatttggcg gctgtaaaaa gcatgacgca 3386401 aagcttccat aacttttttt atgcgtcatt tgacccttct ggatttgtga cagtagataa 3386461 gcctcctgtc gtgttatgga ttcaaacgat tttcgcactg attttcggtg ttcacacgtg 3386521 gagtgtcatc attccccagg ctcttgccgg agttggatct gtcttccttc tctacagaat 3386581 ggttaagccg acttttggag ttggagcggc ccgcattgcc gcacttgtca tggcactgac 3386641 ccctatcgca gtagctgtca gccggacaaa caatatcgac agcatgcttg tttttacctt 3386701 attgctcggt tcaacttgtc tgcttagggc agtaaaacaa ggcaagctgg tttggctgct 3386761 gacggcattt gccctgattg ggctcgcctt taatatgaag atgatgcaag cgtttatggt 3386821 attgcctgca tttgtgttat tctacctgat tgcatctcgg gtttctctga agaaaaaaat 3386881 cgggtccctg cttctgtctc ttgtccttct gacaggcctt tcactctcat gggcgattgc 3386941 agtggattca gcctcttcct caagccggcc ttatgtagga agcagccaga ctaactcagt 3387001 gctagaactg gcctttggct acaacggcac agagcgtctg tttgggcaaa ctacgggcct 3387061 tgcaaagggt gatatgaatg ctgctggcgg agggaacatg cagaatcaag acaacatgca 3387121 agcgccaaat ggcaacggtt catctttttc tcagaacggt aatcaatcat tcggaaacca 3387181 ttcacaggcg cctcagccgc ctaacggaca aaccggcgct ctcaatggag gcggaggcac 3387241 acctcccaca ggtggcaacg gacctggaaa tggagggcct ggcggcggag gcggaaaaag 3387301 cgtgaatatg ttcggcaccg gtgatcctgg accgcttcgt ctcttccaat cagcactttc 3387361 cggccaaatc agctggatgc ttccattctc attgatcgga ttactgggcg caatcatcag 3387421 ctggtaccgt gatcgccgcg gacatgctgc taaaatgaaa gaaacgctat tctgggcggc 3387481 ttggcttgtt cccgtggctg gtttcttcag catcgcagga ttcttccacc agtattattt 3387541 gattatgctg gcaccgccga ttgccgccct ttctggtatc ggatggtata cgatgcaccg 3387601 cttatacaaa aataataaag actggtccag ctatcttctg ccggcagccg tcttgatcac 3387661 agccgtgttt caggtgtata ttctgagcgc ttatacaagc caaatcggca gtgtatggat 3387721 gtatgtcctg gggctcttag gactgggcat cacccttgca cttctgatgc ttaaacgcag 3387781 ccatccgttc agtaagctgc tgaccatcat cagcttgtgc gttctgcttc tcacaccagt 3387841 ttactggtca gcaacgccgc ttctatacgg tggcaacagc gtccttcctg aatccggccc 3387901 gcagctcaaa ggctcagcaa acggcgggaa catgttctct tcagaggtcg acagcgggct 3387961 cctgtcctat ctgagaaaac acaataccgg cgaagagtat ttatttgcta ctttgacaac 3388021 cgtaacagct gcgccataca tcatttacga aaatgaatct gttatggcaa tgggcgggtt 3388081 taacggcacg gatcccattc tgactgtgtc ggaactgaaa aaactgatca aagaaggcaa 3388141 agtgaaatac ttccttctgt cagaaaacaa ctcaggcaac agcgaacttg tttcctggat 3388201 taagaaaaac ggaaaagaaa taacatctga cgagtacagc ggttcctcca gcagcacaaa 3388261 cagcgtgcag ggaatgcgaa gaggacctgg cggagaaagc cagcaaactc tttatctcgt 3388321 ggaataaaaa aagaggcttg gatgaatcca agcctctttt ctattaagct tcttctttta 3388381 catgtacctt taacacagcc tgcacttcag gatgcagctt cacaggcacg tttgtatatc 3388441 ctaatgcacg aatgccgtcc ggcagttcaa gcttccgctt atctacttta atgttatggt 3388501 ctttttggag ctgttcagtg atttgcttgc ttgtcactga accaaataaa cggccgccct 3388561 cacctgattt tgcgctaagc tcaacagtca gtttttctaa tgtctctttc aagctcttag 3388621 cctgctcaag ctcagcaatg gcttcttttt tctctttctg cttttgtccg tttaacgcgc 3388681 tgatgtttga cgcgttcgct tcaaccgcga ggcctttttt aattagaaag ttatgcgcat 3388741 aaccgtctgc tacgtttttg acttcgcctt tttttccttt tccttttaca tcttgtaaga 3388801 aaataacctt catctctgta cgcctccctc aaaatactca tctatggcgt gcttcagccg 3388861 ttccagcgct tcagaaactg aaatgccgga caactgagtc gccgcatttg ttaaatgccc 3388921 tccgccttcc agggcctcca tgatgatctg aacatttacc tcgccaagcg accgagcact 3388981 gatacaaacc gtttgttcat cccgtctcgc caccgcaaat gaagcctcaa cctcactcat 3389041 cgatagcagc gaatcggcag cctgcgcaat cagcacttga tcgaagtatt cctcttcatt 3389101 ttcaggaaga gaagcaatcg caatgttatc tttatagagg accgtatgct ggatcagctt 3389161 cgcccgttta atataggaat caacggtttc tttcagaaac ttctgcacca gcaccgtgtc 3389221 ggcgcctttt gcccttaaat aagaagccgc atcgaaagtc cgcgagcccg tgcggagaga 3389281 aaagctcttt gtatccacta ttataccagc taatagggct gttgcttcaa tcatattgat 3389341 ttttaagcgc ttcggctgat attcaagcag ctctgtcacc aattccgctg tggaagaagc 3389401 gtatggttcc atataaacga gcagcggatc tctgataaac tcctcacctc ttcggtgatg 3389461 gtcgatgacc acgatatgtt caattttatt gaccagccgt tcctccatga cgagtgacgg 3389521 cttatgtgta tcaacgatca caagcagtgt gtcatcattg gaaatctcca ttgcttcttc 3389581 aggcgtaata aatcttgacc acagttcttc atattttttg atttccccaa tcaaacgctg 3389641 cacacttgat ccgatttggt ttgggtcaat cacgataaaa ccatctttgt tatttgcctg 3389701 agccaccttt aaaatcccga tcgctgcgcc gatagaatcc atgtcgggga atttatgccc 3389761 catgataatc acattgctgc tttcggtgac gatttccttt aaggcgtgag aaatcacgcg 3389821 ggcccgcacc cttgttcgtt tctccattgg gtttgtttta ccgccgtaaa acttcacctt 3389881 gccgtttggc agcttaatgg ctacctggtc tccgccgcgt cccagtgcta agtccaagct 3389941 ggattgcgcc aaatcgccaa gttctttcag ggaagagact gaagccccga caccgacgct 3390001 taacgtcagc gctacaccgt caaacgaggt tttttcccgc acttcatcaa gaatcgaaaa 3390061 cttcgaattt tcgagttcag ttaagatatg ttcattaagt acagcaataa agcgttctga 3390121 agacgtcctt ttcaagaaga tcccgtactc ctgcgcccaa gcgttcagca aagatgtcac 3390181 ctggctgttc atcgtgcttc tcgtctggtc atccaatcct tgtgtcacat catcatagtt 3390241 atcaaggaaa atatatgcca ggacggttct ttcgttttca tatagctttt caatctggat 3390301 ttgttctgtt acatcaaaga aatataagag acgctcatcc cgtttgatga caaccctaaa 3390361 cttgcggtca ttcaatgtaa ccgtttccga ttccacctct tgtttgataa gcggcactac 3390421 cgattcacaa gtatcgtaaa gtgatctccc cactaaagtg ctttcattaa aacaagagga 3390481 aagaaacgga tttgcccatt ctatataata ttggtcatta aaaagcatga ttccaatcgg 3390541 catttccatc aatgcctctt caccgacttt tttcaacctg taggacaacg tagaaatata 3390601 agcatcaatc tcttgtcgaa taagagaatc agcacgctta ataaaaaaca aaataactgc 3390661 cagcagcagc acttcgacgg ttcctaatat ccagttaaaa taaaagctga tgaggattgt 3390721 aataattgac agagcaatca atgcatagat gggataccga aacagcggtt tttcataaaa 3390781 gcttggcatt tctatcactc cccaccatgt gagtaaaact catgttcact tcaccttatt 3390841 ccttatatga aagcccatat ctaaaacgcc taaaatgcga atggccgcca tgaagaccgg 3390901 atgcacaaac ccaagtatga cagcaatcac agccgcagcc tttggatatt gtttcttatg 3390961 gcaatagaaa aagataaatg ataaaccttg gatgaaaatc agaaacccga gtataaactc 3391021 cccatttaaa gcgatagagt acagcatttg gcctttttct aaaggcaaaa atgaaagcat 3391081 gacaataatc aaatacagta ctacaacact ttgcggaaac ttcaactctc taaaaggctt 3391141 tagattagga atatcggggg agaatcgcct taagagcggc ttagcgataa ggtaactgag 3391201 gaaagaaaaa ataactccta ccatcacaat agctgttgga aaaagatatt gaacgatacc 3391261 caattgttct tccatcagtt ttaattgctt ctcaaactgc ccagcattgc ccgactgctt 3391321 cgctacagtt tctacaatat caagagattg ccggtattgt gtcattgcct catcaatgat 3391381 attgataccc aaaaactgaa tgcttatcac aaaatagaag acaatactaa gcatataaat 3391441 aagagcgccc gaaataatgg cgtgcccggg ctctttcctt ttgaaaaaat gtcccatggc 3391501 aatgccggcg caagctgaca taaaagctac aataagcccg ttaaaggacc cgacaataaa 3391561 aacaaccgga agactgacag cgcccatcca tatccctagc ttcaatccat gtctgatcgt 3391621 atacaagatc attggcagcg gcagtgcaaa taacagaatt gttccaatca caggaacata 3391681 aacgaccaga agcgtaatga tcgcaaacag actgattaaa atagcacctt ccattaaagc 3391741 tctcgtttgt ttcacttagt cacctcgtat catcctgaac atacgaatag aaaagagcag 3391801 cataaacgac tgctcttttg ttcatcgctg caacatgctt tgcaccgaat gtttttatat 3391861 catctctaaa ttttactttt atattttaac ataagtccaa atcgcaagta aaatgacgct 3391921 aatgtttcat gtgaaacatg aaaaaggaaa agacattctt tgaaaagaat gcccatcaca 3391981 attaatgttt atcatccata aagccagaag attccttgtt tttctttttc gtttttctga 3392041 catacataaa aattaagatc accagtaaaa gggttgttgc ttgcagaacg ccgctgctaa 3392101 acaagaaaaa gttctttatc atgtcccaca ttgtgtttca cctctttgtg catgttctca 3392161 acccgtatcc tatataaggt gaatttccct ttttaaaaac ttcaaaacat catgaacaac 3392221 attgagcgtt gggcatatgc tgatatggaa tctgatcgat aaaggagaat tttcacatgg 3392281 atgaacgcag aacattggct tggcatgaaa cattagaaat gcacgagctg gttgcttttc 3392341 aatcaaacgg actcattaaa ctgaagaaaa tgataagaga agtaaaagac cctcagctca 3392401 gacagcttta taacgtgtct attcagggtg ttgagcaaaa tttgagagag cttcttccgt 3392461 tctttccaca ggctccgcac agagaggatg aggaagaaga acgcgcagat aacccatttt 3392521 acagcggtga cctgctcggt tttgccaaaa catctgtccg cagctatgcc atcgcaatta 3392581 cagaaacagc aacacctcaa ttaagaaacg tactggtcaa acagctgaat gctgccatcc 3392641 agctgcacgc ccaagtttat cgatacatgt atcagcatgg atattatccg tcttacaacc 3392701 tttctgaact gttgaaaaac gatgtcagaa acgccaacag agccatttca atgaaataaa 3392761 acaagcagca aaggagttcc ctttgctgct atttctgctg atccttcact aagccgttcg 3392821 aacgataaga ttccagcacg tctctgttgg attctcccca ttctttcatt tgcaaaacaa 3392881 tcggttcaag cgtgcgccca aattccgtca gagagtactc taccttgggc ggcacctggt 3392941 gataaacctc acggtgcacg atgccgtccg cttccagctc cctcagctgg agagtaagca 3393001 ttctttgagt aatactcggg cagattcgcc gaaactcatt aaatcgtttc ttgccatcta 3393061 tcatgtgata aaaaagaatt cctttccact ttccgccaat gacatctaga gtgaattcaa 3393121 ctggacagcc ttctttgttc gggtatatat tctttttttc actcattctt gaccctccaa 3393181 tagtaccttt tttgatacta cattacattt tgcaactaat ctacccagta ttttacacac 3393241 cttttctcct tagctcaaag aaaatgcttc ttattcacat caatttttaa gggtttgcat 3393301 gattacacct gcagcaagac gtgttaaact atataaagat tacactactt aaaaaaggat 3393361 aggagctatc atggaaaaga tacttatttt cggacaccaa aacccagata cagatacgat 3393421 ttgttctgcg attgcttatg ctgatttgaa aaacaaactc ggcttcaatg ctgagcctgt 3393481 ccgcctcgga caagtcaacg gcgaaacaca atacgcgctt gactatttca aacaagaaag 3393541 cccgcgtctt gttgaaacag ctgcaaacga agtaaacggc gttatcctgg ttgaccataa 3393601 cgaacgccag caaagcatca aagacattga agaggttcag gttttagagg ttatcgacca 3393661 tcaccgcatc gctaactttg aaacagctga gccgctttac tatcgtgctg agcctgtagg 3393721 ctgtacggct accatcttaa acaaaatgta caaagagaat aacgtgaaaa tcgagaaaga 3393781 aattgccggc cttatgctgt ctgcgatcat ttctgattcc ctgttattta aatctccaac 3393841 ttgcacggac caagacgtag cagcagcaaa agagcttgcg gagatcgctg gagtagatgc 3393901 tgaagaatac ggcttgaaca tgttgaaagc aggcgctgat ctaagcaaaa aaacagtgga 3393961 agagctcatt tctcttgatg cgaaagaatt tacactcggc agcaagaaag tcgaaatcgc 3394021 acaagtaaac acagtggaca ttgaagatgt aaaaaaacgc caagctgaat tagaagctgt 3394081 gatctcaaaa gttgtggctg agaagaatct tgatctgttc cttctcgtta tcacagatat 3394141 cttagaaaat gattcacttg ctcttgcaat cggtaacgaa gcagcgaaag tggaaaaagc 3394201 gttcaacgtt acattagaaa acaacacagc cctcttaaaa ggcgttgttt cccgtaaaaa 3394261 acaagtcgtt cctgtcttaa cagacgcaat ggctgaataa gccattacaa ttgcttcaaa 3394321 atccttgcgg ggtttccgcc tacaacagta ttagcgggta catccttagt gacaacagat 3394381 ccagaagcaa tcactgcgtt atcaccgatt gtcactcccg ggttaatcac cgcccggcct 3394441 ccaatccaaa cttgatctcc aattgtcaca ggcttaccga actccttccc ggatttcctt 3394501 tcgatcggat caagaggatg accggccgtg tagatatgta cacctggcgc aatcaaacaa 3394561 tgacagccga tacgcacctc acacacatct aaaatgacac agtcaaaatt aacaaatgta 3394621 tgatctccga tatgaatgtg atagccataa tcacagcgga atgtcggcaa aatcgtgact 3394681 tgatccccaa ccgaaccgag cagctccttc aaaagcttcg tccgcactgc atcatcttcc 3394741 ggtgtttcgt tgtattgtct aatcagctgt ctcgcatgct tgcgttctag taatagttgt 3394801 tgatcttccg aattgtataa ttctccggct gccatttttt ctttttctgt cctcagcatt 3394861 taagtcactc cagatgtcag attgtaatct cgatcaaatt tccttcatca tcctcaatca 3394921 cgctttcata gtagccgtct cctgttgtcc tcgggccgtt tactactgcg aaaccatccg 3394981 ccttcaatcg atcagtcagt tcgtcaactt tctcccggct cccaacggaa aaggcaatat 3395041 gtgcccagcc tgtcattgtt tgtgagggcg gatcggtcac attccctttt ttcataattt 3395101 ccagccttgc tccggaatca aacgtaataa aataagactt aaaatctttt ttctcattat 3395161 gatacaaatc attcgcttcg ccattaaaat acgattcata aaaagacttc attcgctcta 3395221 aatcattgac ccagaccgct gtatgttcaa tctgcatttc ttcctcctcc ttcgccttca 3395281 atgaagttat aaggtatgaa atgcatttca gttcaagctt ttttcttaaa tttatgctga 3395341 attttgatat cagcgggttc atcctgcaaa aatagagaaa atgctgcgat gccgagctgc 3395401 tcaagattca aatcaagcga cggaaaacca agaacacggc tgatagaagt atttccctcg 3395461 cctatgattt caacatccca attattcttt ttggcaaata gatgaattcc agctgccact 3395521 tcatcactat ttgcataaat agcagtcgga acccgcccgc tcatataaaa atgttcagct 3395581 gccagctcac catcattcat atcgttgcat ccggacagca tatggcggtc ttccaacctt 3395641 ccgcagacag ctttataggc cgcagcttta tcagccgtgc tcgggctcct atcagcttct 3395701 ctgacacacg taaaagcaat attctcatgc ccgcggctct ttaaatagcg aaagctctct 3395761 gcataagcag tttttctgtc attaaaagca caagggacat caatgtctcc ggtatcctca 3395821 caagcgatga ccggcccata ttcctgataa gctaaaatgc tgtcccaatg attggcgcgg 3395881 gaagtaatga tgagaccgtc tattttcttc gttcttaaca gctctaaata tttgatttca 3395941 atatcggggt tataattggt ggggagaagg gtcgttgcat actcatgctg aaaagccgcc 3396001 ttggtgattc cgttaacgat tttatcaaag cagggatgat cgctataagg cagaatcaca 3396061 ccgaccgtat gggttttccc gcgaatgaga tcgattgcgg ttcgatttgg tgtataatcc 3396121 aattccttca tgacttgatg aacaagcttt ctcttttctt cagatacata cggatgatga 3396181 ttcaatacac gcgagacagt cgaaacagat acatttgcca gtcttgcgat ctcttttata 3396241 tttgccatct ctttctcctt ttcatataaa aaaagcagta agtgtaaaat ccttactgct 3396301 atctcatcat atattgatga taagttcaac aggacaatgg tcggaaccca tgacgtccgc 3396361 tgatatgctg gcatcttcaa tctgttcctt aaggctttca gaaacaacaa aataatcaat 3396421 ccgccatcca atatttctgt cccgggcgcc ggcacgatac gaccaccagg aataagcgcc 3396481 ttcaagatca ggataaacat gacgaaaaga atcaacaaag ccagcttcta agaaacgagt 3396541 gaatgcctct ctttcttgat ctgaaaatcc agcgttattc cggttcgcct ttggattttt 3396601 caagtcaatc tcctgatggg ctacattcaa atcaccgcat aaaatcactg gttttttctg 3396661 atccaattca agaatataag acagtaaagc ctcttcccat tgcatgcggt aatcaatccg 3396721 ctctaatccc cttctggaat tgggcgtgta aacagtcatc acaaacacgt tttcaaattc 3396781 cagcgtaatc actctgcctt cttggtcatg ctcttctact ccgataccgt agatgacctg 3396841 cagcggttct tgcttagaaa aaacagctgt gccggaatat ccttttttca ctgcataatt 3396901 ccagtacaca tgatagtctt caggctggag atcaacctgg ccgtcctgta tcttcgtttc 3396961 ctgaagacat ataatatctg catcctcttc tttcaaataa gagaggaaat ccatttttct 3397021 catcacagcc cgcaggccgt ttacattcca tgaaatcaac ttcatgtttc atcctccccc 3397081 ctataaaaaa gagcaagaac ccgaaggtcc ttgctcttta catatcagct tactcaccgc 3397141 ttacgtatgg aagtaaagcc atttgacgtg cgcgtttgat cgctgcagtc aatttacgtt 3397201 ggtatttagc gtttgttcca gttacacgac gtggtaaaat tttaccgcgc tcagaaacaa 3397261 actttttaag aagatctaca tctttgtagt cgatgtgcgt gataccgtta gaagtgaaat 3397321 aacacacttt acggcgtttc gcacgaccgc ctctgcgtcc tcctgccatt gtcatttccc 3397381 tcctttcttt ttcattttag gcgataatca cattagaatg gaagatcatc atccgagatg 3397441 tcaatcggtt tgccgtcgtt ggcaaatggg tcatcattaa agctgttccc ctgattgcgt 3397501 ctctggttgt tttgatttcc cccaaatgga ttatcatttt ggcctccgcc aaagtactgg 3397561 cctccgccgc tgtttccttc gttgtatcca cctgaaccag aaccgccgcc gtttttcggc 3397621 tcaagaaatt gaacactttc agcttggacc tctgtcacga agacacgctg tccttgctgg 3397681 ttttcatagt ttcttgtttg taaacggcca tctacgcctg caaggcttcc ttttttcaag 3397741 aagtttgcaa cgttttcggc ttgtcttctc caagtgacac aattaatgaa atcggcctca 3397801 cgttctccgg actggttcgt aaatgtacga ttcacagcaa gagtaaacgt agcaacagcc 3397861 gcaccgtttg gcgtataacg aagctctggg tcttttgtca gtcttccgac taatacaact 3397921 cggttaagca taagaaagac caccttttac cattatatat ttcaaaattg cttattcttc 3397981 ttctttaaca acaatgtggc gaatgatatc gtcactgatc ttagctagac ggtcaaattc 3398041 ttgaactgcc gcagcgtcag attgaacgtt tacgatttgg tagaaaccgt cgcggaaatc 3398101 gttgatttcg taagcaagac gacgtttacc ccaatccttt gttccagtga tctccgcacc 3398161 gttagaagtc agaacgttgt tgaaacgctc gataactgct tttttagact cttcgtcaat 3398221 gtttgggcgg ataatgtaca taacttcgta ctttctcatc tgtttgcacc tccttttgga 3398281 ctaagcggcc cataatgggc aaggagcaat aattctatta ctcacaattt tatattatac 3398341 caaagctctt gtccctttac aactgcatcc tatacattaa atcggaaatg aataacatct 3398401 ccgtcttgga ccacatattc tttcccttca aggcggactt ttcctgcctc tttagctcct 3398461 gccataccgc cgcccgcaag aagatcctca taagcaactg tctcagcacg aatgaagccc 3398521 cgctcaaagt cactatgaat aattcctgca cactcagggg ctttcatgcc ttttttgaat 3398581 gtccaagctc tgacttcctg ttctccggct gtgaaatatg ttgcgaggcc gagaagagag 3398641 taagacgctt tgatcagctg atcaagacct gattcttgaa tgcccagctc ttccaagaac 3398701 atttgctttt cttcgccttc aagctcagcg atttcagatt cgatttttgc acacacaacg 3398761 ataacttctg cgttttcgcc ggcagcgtac tcgcgaatct tcgctacatt ttcattgcca 3398821 gatggatcag caacttcatc ttcacttacg ttggccacgt acaaaatagg cttcgaagtc 3398881 agtaaatgga gctgcttcac aagcttttgc tgctcttcag tgaattctac agatcgagca 3398941 ggcttttcac tctcaaacgc ttctttcagt ttagataaaa tctcaaactc aaatacagcg 3399001 tctttatctt tttgcttcgc aagcttgctg acgcgtgtaa tccgcttttc aactgtttcc 3399061 atatcagcga ggatcagctc aaggttgatc gtttcaatgt catcaatcgg atcaaccttt 3399121 ccggaaacgt gtgtaatgtt gtcatcggaa aaagcacgga caacgtggca aatcgcgtca 3399181 acttggcgaa tatgagatag gaacttgttg ccgagtcctt ctcctttaga tgcgcccttt 3399241 acaatccctg caatatcagt gaattcaaaa gcagtcggca cagtcttctt cgggttgacc 3399301 agctcagtca gcttttgcag acgatcatcc ggcacctcta caattcccac gttcggatca 3399361 attgtacaga acgggtagtt ggctgattcg gcaccggcct gtgtaattgc gttaaatagt 3399421 gttgattttc cgacgttcgg caaaccaaca attccagctg ttaaagccat tctttcatct 3399481 cctctatata aaaccgtcat tgtatgaacg tattttgaac ctagagcaat tataaggagg 3399541 ttcactggaa aagacaagct gacaaaaaag cattttcagc ttgccaatcc ctttgattat 3399601 gcttttttca agcctactaa acagtcaaaa agcgtacttc ccattccatt atcagaattt 3399661 gtatcatttg tcagtgcatt gactgaccct ccaaaagccg cccacatgcc ttcatctata 3399721 ttaatcgtct tcgcatgagc ctgcttcatc actttcacct tgcccttcat gcttccgcgg 3399781 tcattaaaga tgacaacttc gtctccatcc tgaagatcct gcccagccgc tatatctgga 3399841 gaaatatcga cctgaacgtg ctgaagcttt tcaataaacg gcacatgctg tgaatgattg 3399901 gaacgctgcg gatgaatgga taagagcgta taagggtact ttccagctaa ctcctcatta 3399961 tggaaaacag attcttcggg cacatttaat tgaagcgagc cgctaaatcc tttttgctca 3400021 gctagcgacg aagtaaattc aaattttcca ctcggcgtca aaaactgata atcatcccac 3400081 ggcacctgtt ttactggaag agggaggtgg cctttttctt ttaaacgctc aagtgtcaca 3400141 tcctctgctt ccaatgaaga aagccccatc tctaaaaatt cttgagtgct gtattcaaac 3400201 agctcgccaa acccaagacg ttttgcaagc tctgaccaga tccagctgtc cgatttcgct 3400261 tcaccctgcg gctccacaag cttcttcccg tactgaacat aatgatgata catactggaa 3400321 tagtagatat cttcttcttc aaaaacagtg gcagtcggca aaacataatc acacagctct 3400381 gcggtatccg tcataatgga atcaatcgcg accgtcattg gaaccttttc aaatgcttgt 3400441 ctcaccttat ttgtattcgg cacctgagtc agcggatttc cgcacgtcac aataatcatc 3400501 tcaatcgcag gatcagcagc ggtcaacact tcttcagcct gtgtcatcat tgaaaaagaa 3400561 cgggatgttg tttttaattc cggcagcgtc agctttgttt ttgcaaagct ctcaccaatc 3400621 tggacatttc cgaaattcgc gccgccgccc ttaattccga catttccgct tgccgccaca 3400681 agtgcatcaa tccaacgaat cgttcccccg ccgtttttat atcgctgcat gccaagcccc 3400741 ataaaagtag acaccggacc atcagcatac aaacctgcca aatactccag ctcctccata 3400801 gaagtttctg ttttcacaat aaactcttcc agagaaacgg tcttcaaaag ctctttcaca 3400861 tcatcaaaac cgacagaatg ctcagaaata aacgtttcat ccgttcttcc catctcaatc 3400921 agaaccttca aaacggctgc cgcaagccag ccgtccattc caggctttac agagatatag 3400981 cggtcggcaa gcttagcagt cgggttgaag atcggatcaa tcaccgtaat cgtggcgccc 3401041 ttctttttca cctgctgcaa gtgatggtat aagtgcatat ttgttcttga tacatttctt 3401101 ccccacacaa caacatgctt gctgttgtaa atatcaagcg gtccgtgacc gtacgaacgg 3401161 ccaaaatccc agctttgcgc ctcgataccg gagccccagc atatgcttcc gacgatttcg 3401221 gtcacgccgc catatccatt aaaaaaacgc tgatcaagcg cttttaacag accgttattc 3401281 gcataatcat ggctgtgcaa aacagcagtc gtctccgacg tttccttgat ttcccgaagt 3401341 ttatcggcaa tttcatcaag tgcctgctcc caagaaatcc gcacaaactc gccattttgt 3401401 tttttcattg gatagcgaag ccgatcaggc gaatttgttt ttgtctcaag cattctgccg 3401461 cggccgcaga ttttaccttc cgtaatcgga tggtttggat ctccgtccac ttttgttacc 3401521 tttccatcat caacagtcac caaaaagccg cagctgtccc aacaattcag cggacatgcc 3401581 gactgatgca ctttgctcat cgccgtcttc tccttacctt ctatatgaaa aagcatgagt 3401641 gtcggcctat ttatgaagta ggctcctcat gcttgactag tacttttttt agttttcttt 3401701 caaattctct tctcggaatc ataacactgt gagagcatcc ctcacactta attcgaatat 3401761 ccattcccat gcgtataatt ttccagctgt tcgctccgca tggatgcggt tttttcattt 3401821 ctacgatatc attcaggcca aagtctttat ccgccaagac ccttcacctc ttttcctaaa 3401881 ctgctgtatc tattgtacaa aaaaactgat cataagagca atcaagatac ccgaaaagaa 3401941 atacatcctc ttatttccat ttactcaaaa taggatataa gagcagacaa actaacaaat 3402001 acaaattgag catcccatat atcggataca agaacgcgat caaatcagaa aatccgaaag 3402061 aagtaaaagg taccattaac actaacaaaa tcaacacaat catccatctc ggcatatgaa 3402121 taaacgccat cagccggctg gacaaaccca gcaaaccagc taccgtcgtc gtgtaaatcg 3402181 ccaggcacag caccgccgtc atacataaaa aaaggaaata aggcgcaccc tccagaacgg 3402241 caaacagcgg tatttcaaac tgagaaaggg agcccgccag ctccaccaac gtttcattat 3402301 aaacaaatga gatcacgcca aaaataagac cgcttgccac acttgcgatt tttgcttctc 3402361 cgagcccttt catctctttc ccaacagagg ataaaatcgc aacaactgaa aggatgttta 3402421 aagaggtaaa cgtaatgctc gcaggccagt tatactgctg ggacaaatca atcgtccacg 3402481 tatggtgatg tgtgctctga aaggagatca gcgcatataa aagccccgct actaacacag 3402541 gaatcaaaat actatttata gataatattc ctttcacatc ccacaaaaac aagcacactg 3402601 tcacgatgca aatcagcgtg attccccacc agaaaggaag cttgtacatt tgcagggtca 3402661 caccgcctcc ggcaatcatc accatagtcg tcgaaaacaa ataaaaaatg atgaggacat 3402721 cataaatttt cgccagccat ggccccatta aatgctccag aaccggcaga aaatgagtgg 3402781 attgaacctt aaaactgatt ttcatcacaa tataagacga gaaaatgaac ataattgtaa 3402841 acagcacaat agcaagtccg ctttccgccc caaaaaactg ccatatctcc tgaccgctcg 3402901 catatccggc cccgatcagg ctccctaata tgagcagcat ccacttcatt ccggctctcc 3402961 acaacactat cacctcatag acaaagttca gcttgttccc gttattgtta ctatataaat 3403021 aaaggaaagc aaacatgcca tattttcata gacatttgaa cacaagctga aattatcata 3403081 cgaaatacac ataaaaaaga ctgctaatac ggcagtctaa aaagagatat ttatttgttt 3403141 gtccgcggaa tgaagaagtg aacttcactc ttcacttttt tctaaccatt cctacctatt 3403201 caagtgtttc ataagcagac cattgcttga tcatgatcga ggcaatgggg gacaatactt 3403261 gtaatcgccc actaaccatt catatcatgc cctctacttt tttaaaatct ctggtgccat 3403321 acacaaagca taaaaaatca tactgctgga tatactgtaa acaaccttac ataactacac 3403381 acaccatagc aattctgtta cctactataa caaggaagtg aaacccatga atcgaaaagg 3403441 cgggcttttt tcttctcagg aacgagtaaa gcaatatgtt tcacatacag atgctgcagc 3403501 ggcaaaacaa atccaaacca tcctttcttc atccttacgt aaagctgctg gcaaaccaat 3403561 tgtcgtggtt tgtatcggaa cagaccgttc aaccggtgac tcattaggcc cgctcgtagg 3403621 aatgaaactc aaacagatgc agctcaccag attccatgtc tacggaacct tatctgaccc 3403681 cgtccatgct gtgaacatga aggataaaat caatgacatt cataaattac ataaaaaccc 3403741 atttgttata gcagtcgatg catgcttagg ccgcgttaag agtgtgggtt catttcaaat 3403801 cggggacggg ccattaaagc ccggagccgg tgtacaaaaa gaccttcctg aagtgggaga 3403861 tcttcatatt aacggaatcg tgaatgtgag cggttttatg gaatattttg tattgcaaaa 3403921 tactagactc aacttggtca tgaatatggc aaatgttcta gcggaaggtt tgagtttaac 3403981 agatcggaca gagtggaggc aagaacgcct taacccgttg caaaggctca ctgggcgcat 3404041 ataaaataaa aaccatcttc gtttgaaaga tggttttttc atttatgatt ctcgttcaga 3404101 caaaagctct aaaatccggt caaggtcttc attagagaaa aattcaattt cgattttgcc 3404161 ttttttcttc tgtcttttaa tattaactgt tgttccaaaa taattttgga gataggattc 3404221 ccgttctttt agaaccgcat ctttcacagg ttcttttttc tttgtttcac gtggaacatt 3404281 ctgattcaac tgctgaatca gctgctcaag ttggcgaaca ttgagctgct ccgcaatcac 3404341 tttttgtacc agcggttcaa gcttattttt gttttttaag ccaagaagcg tgcgtccatg 3404401 tcccatagaa agcgtgcctt cggcaataag ctgttgaata ttttctggca gtgtcagcag 3404461 tcttaaatga ttcgcaatat gcggtctgct tttcccaaga cgtttggcaa gctgctcttg 3404521 tgtgagatct aagtgtttca aaagggagtc atatgcctga gcctcttcaa gcggagataa 3404581 atcttcacgc tgaaggtttt ctaataaagc aatttccctc attaacgcct ctgataattc 3404641 acggacaatg gccggaactg tatctaaacc tgccagcttt gccgctcgaa aacgccgttc 3404701 acccgcaaca atatcatagc cttttaaaga ttttctgacg ataagcggct gaagaatgcc 3404761 atgctgcagc acagattctt ttagttcagc taatgcctcg tcatcaaagt gttttcttgg 3404821 ctgataagga ttagggcgta aatcggcaat tttaatttct tcaactgtct cttcagacaa 3404881 atctacctga ttaaataacg cattaatccc ttttccaagg cctttagcca ttcgcagcca 3404941 cttcctttgc taaatctaaa tatacttccg cacctcttga ccgcggatcg tataaaatga 3405001 tgggttttcc gtgactcggt gcctcactca gacggacatt acgcggaata actgtcttat 3405061 atactttatc cctaaaatac tttttaacct cttcaatcac ttgaatgcca aggtttgtcc 3405121 gggcatcaag cattgtcagc aatacacctt caatcattaa atcagtattc aaatgctttt 3405181 gcacaagacg tactgtattt aataactggc tgagaccctc caaggcataa tattcgcact 3405241 gtacaggaat cacaacggaa tccgaggcag taagggcatt aatcgtcagc aagcccaatg 3405301 acggcggaca atcaatgata atataatcat aattttgctt tactgcttca agcgctctct 3405361 tcaatctcac ttctcttgat attgtaggaa ccagctcgat ctcagcccct gcaagctgaa 3405421 tcgtcgcagg aatcacatcc aagttctcta ctgtcgttgc tttaataata tctattacat 3405481 ctgcatcatc tactaaaata tcgtacacac actgctctac atcggctttt tcaatcccta 3405541 atccgcttgt cgcatttccc tgcggatcaa tatctaccag cagaaccctt ttccctatgt 3405601 aagccaaaca tgccccaagg ttgacagacg tcgttgtttt gccgaccccg cctttttggt 3405661 tcgtaattgc tatgattttt cccacgatgt cacctacttt cacatgaaca tgtactatct 3405721 tgcttctatt ctatcaaaaa aagattaaag cgtttcattt ttttcatcat tttgttccga 3405781 atcagaaggg aaataattga aaattcaagc acgctttatg ctttctctta taaattctgc 3405841 aatttctatg tttttttgac ttaaaaaagg aatttcttaa agaaaaaaag aagaagtcac 3405901 agtacagaac gtggaaacag gatggtgaga aaatggttta tcaaacgaag agagatgtac 3405961 ccgttacgct gatgattgtg tttctcatat tactgataca agcagatgcc attgttcctt 3406021 ttgtgctggg aaatatgaga gtttccggct ggatcatttt tattctgctg actcttttaa 3406081 atggactcat catttggagc tttattgacc taaaatatgt attgaaggaa caccatctga 3406141 tcattaaagc cggattgatc aaacatcaaa ttccttatga aaacatcgat aaagtcgttc 3406201 aaaaaaagaa actatggtcc ggttttcgtc tgatcggctc tcgccatgcc atcacaatat 3406261 attatcaggg gggatgggga catgcagtaa tttcaccgca aaaatctgaa gaatttatcc 3406321 acaagctcaa agaaaagaat tctaatataa taatattcac taaaagtaag tgattacctt 3406381 ttgttaaaaa tataaaaagc tctcctgctt ttcaggagag cttctatttt ggtatgcgaa 3406441 tcgttaattg aatatattct tcaaattctt cttcttccgt attcaatttt acaccgctgt 3406501 cttccaccat tgatagtgac tggcgaatcg tgttcatcgc aattcttgta tctctgctga 3406561 atgctttgcg tctcggcttt ggctttctct ggccttgctc cagcattttc accacgcggt 3406621 cttctgtctg ctttacattt aaacttttct caataatctc tgtgagcagt gtgacttgga 3406681 gctcaggctg tttcagcgga atcagtgctc tggcatggcg ctcggtgatt ttcttctcca 3406741 taatcgcctc ttggaccggc tgaggcagct ttaataaccg aagcttattc gcgattgtag 3406801 actgcccttt tcctaagcgc tgtgcgagtg cctcctgtgt taaatcatgc agctcaagca 3406861 gcctagcata agcatgcgct tcctcaatag aagacagttc ttcccgctgc aagttttcga 3406921 ttaacgccac agaagcggtt tccgtgtcgg aaaaatcctt aataattgcc ggaatctttt 3406981 cccactcaag cgattgcacc gctctccagc gtctttcacc tgcaatgagt tcgtattggc 3407041 cttcttcttc tgtatgccta acaacaatcg gctgaataat gccgtgtgta tgaatggtca 3407101 ttgctaactc tttgattttt tcatctgaga aaatggtgcg tggctgaaaa cggttgggaa 3407161 cgatagcatt taccggtatt tccagaatct cttctttgtt tgtatcatgt tcagcaatct 3407221 ccggctcctg ttccttctca ccaagcccga agaaacgaga gaatgaatgc ttcatgtacc 3407281 tacaccacct ttaaaaactg ccatttttat aattctattt tctcatggtt tttcctgctg 3407341 tacatccatc aattttgatg aaaatatgat ggtattgtca tatcaggctg tctaaattac 3407401 ccttcaattg gcgatttatt aggagttccc ggttttcttg gatacttctt aggtgtattt 3407461 tttattttgc gtatcaccat aatattacga tcgctttctt caataggcag cttaaaagaa 3407521 tggatattct caagttctcc tccaagcgtc gtgattgctt ttttgcctgc attcagttct 3407581 tcttcagctg atgcggcttt taaagcaaca aataaaccgt ttttcttcac cagaggcaag 3407641 caaagctcac tcaaaacaga taatctcgca actgcgcgcg ccgtcacaat atcatagctt 3407701 tcacgcacgt ctttccgttg cccgaacgtt tcagctctgt catggcagaa tgttgtattc 3407761 tccaattgca aagcttcaga caacttttct aaaaacgtaa tccgtttgtt tagtgaatcc 3407821 acgattgtga catggaggtg cggaaagcat atttttatcg gcagacttgg aaaacccgct 3407881 cccgctccaa catcacaaat cgtgttcacc tgattgaagt cgacataaaa agcagctgta 3407941 atggaatcat aaaaatgctt taaatacact tcttttttct ctgttattga agtcagattg 3408001 attttttcgt tccattcaac cagcatgtcg taatacagct caaattgctc cagctgacgg 3408061 ggagaaaggg agatcccttt ttccgccaaa ccagaagtga attcttcaat attcatgccg 3408121 tcatcctttc tactcggcta tcttcgcaat gcgtccctgc tctaaataca ccaatagaat 3408181 tgaaatgtcc gccgggttta caccggaaat gcgggaagcc tgggcaacag acaaaggccg 3408241 tacatttttc agtttttgac gcgcctcggt cgcaatcccc ttaattgcgt cataatcaat 3408301 tcggtctgga atttttttat tttccatctt cttcagtttt tccacttgct gaagagattt 3408361 ttcaatatat ccttcatatt tcacttggat ttctacttgt tctgccacgt cttgaggaac 3408421 cggcacttct ggcggcgcca gttttgtgac tgtttcatag ttcatttcag gacgtttcat 3408481 caagtctgtg ccgcgaactc catctttcaa ttcgcttccg ccaagagaac ggatatattc 3408541 ttgattttcc ggagacggct tgataattac agaatgaaga cgttttttct ccgcctcgat 3408601 cgccgctttt ttcttctcaa aagccgcata gcgctcatca gaaatcaatc caatgcgatg 3408661 tccgatttct gtcagacgca aatcagcatt gtcatggcga agcagcaatc tgtattccgc 3408721 acgtgatgtc aaaagacgat atggctcatt ggtacctttt gtcacaaggt catcaatcag 3408781 aacaccaata taggcgtcag aacggcttag aattacttct tcttttccaa gcgcttttcg 3408841 tcctgcattg attcccgcca taatcccttg tcccgcagct tcttcataac cggatgttcc 3408901 gttaatttgg cctgcagtat aaaggtttgt gatttttttg gtttcaagtg tcggccatag 3408961 ctgtgtcggt acgattgcat catactcgat cgcatagccg gctctcatca tttgcacgtt 3409021 ttcaagtcca ggaatcgttg caagcattct ttgctgtacg tcttctggaa gacttgtaga 3409081 taaaccttgg acatagactt cctgtgtatt tctgccttcc ggctcaagga agatttggtg 3409141 acgcggttta tcattaaaac ggacaacttt gtcttcaatg gatgggcagt atcttgggcc 3409201 cgtacctttg atcataccgg aatacatcgg tgaacggtgc aggttgctgt caataatctc 3409261 atgtgtctca gggcttgtat atgtcagcca gcaagggagc tgatctgtga tatattccac 3409321 tgtttcatat gagaaagcgc gaggcacatc gtcaccaggc tgaatttccg ttttgctgta 3409381 atcaatcgtg tcgcttttaa cgcgaggcgg cgtacctgtt ttaaaacgaa caaggtcaaa 3409441 accgagttcc tccaaatgct cagaaagctt aatagaaggc tgctggttat tcgggccgct 3409501 tgagtaagac agatcgccaa gaatgatacg tcctcttaaa tatgtccctg tcgtcatgac 3409561 aactgctttc gcacgataat gtgcgcctgt ttgtgtaata acgcctcggc attcgccgtc 3409621 ttcaacgatc agccgctcca caattccttg cagcaatgtt aagtttggtt ctttttcaag 3409681 cgtatttttc atttcgtgct gatattggaa tttgtctgct tgcgcacgca atgcacgaac 3409741 cgcaggacct tttcctgtat tcagcattct catttgaata tgtgttttat cgatgtttct 3409801 tcccatttct ccgccgagcg cgtcaatttc gcggacgaca atcccttttg cggggccgcc 3409861 gacagacgga ttacatggca taaatgcaac catatctagg ttgatggtca agacaagcgt 3409921 tttggcgcct tggcgtgcag atgcgagggc agcctcaaca ccggcatgcc cggcgccaat 3409981 cacaatcaca tcgtattggc ctgcttcata ccccatgatt ctagttcctc ctttaattat 3410041 tttcctaaac agaattgaga aaagagctga tcaattaagc tttcgtggac agaatctcca 3410101 atgatttccc ctaaaagctc ccagcatctt gtaaggtcaa tttgcaccat gtcgatcggg 3410161 acatcctgtt cgatgccgct aagcgcatct tcaatggcgc gttttgcttg ctgtaaaata 3410221 gtgatgtgac gtgtgttgct gacataagtc agatcaccgc tttcaatggc acccgtgtag 3410281 aacagtgatt gaatcgcttc ttccagatca ttgatgcctt cctcttttaa aagagatgtc 3410341 gtaacaactg gacgtccatt ggcaagctca cggacacgtt cagtgtcaat cttcggctca 3410401 aggtcagtct tattcaaaat cacgataaca tccatgccct caacggcttc aaaaagcttc 3410461 acgtcttctt cagaaagctc ttcactataa ttaagcacaa gtaaaatcag gtccgcttcc 3410521 tttaggacct ggcgagaacg ttcaacaccg attcgctcaa caatatcctc tgtttcacga 3410581 atacctgctg tatcaaccag acgaagcgga acgcccctta cattcacgta ttcctcaatc 3410641 acatcccgtg tcgttccggg aatatcggtt acaatggctt ttgcctcatg aacgaggctg 3410701 ttcagaagag atgattttcc tacgtttggc cggccgataa tgacggtaga aagaccttca 3410761 cgcaagattt ttccttgctc agaagtcctc agcagcgtct caatttcctt tttcacggcg 3410821 gttgcctttt cgactaaaat ctgatgcgtc atttcctcta catcatcata ctccggataa 3410881 tcaatattca cctcaacatg ggccagtgtt tctaaaatct cactgcgcaa acggcgcacc 3410941 aaagcagaaa gacgcccttc catttgattc atagcaacgt tcattgcccg gtccgttttc 3411001 gctctgatta agtccataac cgcttccgcc tgtgaaagat cgattcggcc gtttaaaaac 3411061 gcacgtttcg taaattcacc aggctctgcc agtctcgctc cctctctcaa tgcaagctga 3411121 agcacttggt tcacagtcac aattcccccg tgacagttaa tctcgatgac atcttctcgt 3411181 gtaaaagttc tcggcgcttt taacactgat accattactt cctcaacgac acgatccgaa 3411241 ggtctgtcta cgatatgacc ataatgaatc gtatgtgatt cgaccgagct gagtgttttc 3411301 cccttcggtc ccttataaat tttatctgcg atttgaatgg cttctggtcc gctcaaccgt 3411361 acaatcgcaa tcgcgccttc tcccatcggt gtggaaattg ccgcaattgt atccatgttg 3411421 ttcacctctc tttacttata cttcatctat ataaaaaaat ttttattatg ccaaaactaa 3411481 aagataacat agtttggttc gaagtggaag atttgttatc cacagaaata gaaattcgtc 3411541 ccttattact ttaacttatc cacatgtgaa taacaattaa ttttatttcc tgaacttcct 3411601 ttttatcaac aggatacacc taaaaagaaa aaacttaaac ggcaaaacct tgatattact 3411661 aggaaaagta gatttttcgg atacaaaaaa accgaaatcc aatttttatc ggacttcggt 3411721 tttatgctat cttttatggg aaataacgag atgacgattt tcgccttcac ccattgaata 3411781 tgttttgatc tggtggtttg catatccaga aagagtatcg tgaataattt ttctttcgct 3411841 ggacggcatg ggctcaagct ggatggattt tttcgttttc aaaacctggt cagcaagctt 3411901 gatggccagc tggctcagtg tttcttttct tttcaaacga tagttttctg catccaccgt 3411961 cacattttta tattggcctg gataacggtt aagggcaagc tgtgtcaaag tttcaagggc 3412021 gtttaaagtt tgtcctcttt tcccaatcaa caatgctgcc ttttcacctg ttatatgata 3412081 tctcactgtc tttttgcttt cttgaacagt cacatcagac ttcccggcaa tggcttcggc 3412141 aatcgtttga agatataact tcgcttgctg aatcggatca atcttttcaa ccagctttac 3412201 gatcgcaggc tttttaccga aaataccgag aaaccctttg tttccctctt caataacagt 3412261 aatttctacc ttatccttcg ttaatcccaa ctcttgcaat ccggactgta ctgcttcatc 3412321 gacatttcgc cctgcagcag tcacattcct cactttttct ttcctccggc tttttgcggc 3412381 tcaggatttt ttttaatatc aggtccttta atgaggaaag tttgcgcaat cataaacaag 3412441 ttaccaacta cccaataaag agaaagagcc gccgggaagt tgatcgcaaa tacgataatc 3412501 ataattggca taatccaaag catcatcgcc atttgcggat tttgctgcgc attgccagcc 3412561 atcatcagtt tttgctgaac aaatgtagcg acaccggcaa cgataggaag aatatagtaa 3412621 ggatcttttt ctcctaagtc aaaccataag aagctatgct ctgaaatcgc ctgggttctc 3412681 atgatcgcat gatagaatcc aattaaaatc ggcatctgga tcaaaatcgg gaaacatccc 3412741 gccaatggat tgacaccatg cttttggaat aaagccattg tttcctgttg aagcttttgc 3412801 tgcgtttttt gatcctttga gctgtatttt tctttaagct tttgcatttc cggctgtaaa 3412861 gcctgcatcg ctttcgaact tctcagctgc ttaatcatca gcggtaaaat taataaacga 3412921 attaaaatgg taactagaat aattgaaagc ccgtagttat ctcccgtcaa tttcgctaca 3412981 tacgtaatga gctcagacaa tggatatact acgtacttgt cccagaaatg cggactatct 3413041 gcagtgatcg gctctttcac actcgagcat ccagccaaaa gcatgaatac gccaaccata 3413101 cttaatagca accctattct ccttttcaac aacatttcct cctataatta atctttacac 3413161 tcttttattg caaagcatac ttgtatgtat tttagcatct ttcagtttta aatggtgtct 3413221 ttttctgatc aaccagaaag gaagcgcttt taaaagttgt aagaaagcag tggtgatgcc 3413281 tactttgacg aagatttctt atataatgaa gactttctga atagatgctg cagacttttt 3413341 ttcgtttcct catatgtcag ctggctcgcc ggttttctgg caataatgat gtaatccttt 3413401 tccttcagtc tctctttctc ttcaagaaag gcctgccgaa tcaaacgttt gatccgattt 3413461 cgcatcacag cattgccaat ttttttgctg acggaaagcc cgacacgcag ttcatcattt 3413521 tcaggctgat caagcgtata taagacaaac tggcggtttg caactgatgt cccatgttta 3413581 aacacttttt gaaaatcttc atttttcttt aaacgatttc gcttcttcaa atgactcact 3413641 ccgatactgg ctggcagaaa cttttaaaat ttattatgaa catgagatgc atctgaacca 3413701 ggaagcatgc cccggttcat tacgcatcac atctatcttt tcccataacg tgaaaaaaga 3413761 ccactgacat tattcagtgg cctaagctga taatactttt ctgcctttgc ggcgacggcg 3413821 tgctaaaact agacgaccgt tttttgaact catacggctt ctgaagccat gaactttgct 3413881 gcgtttacgg ttattcggtt ggaatgttct tttcatttat gacacctccc tcgaggaata 3413941 gctgttaaag acagtcttac ttattatatt tgcgttacct attcattgtc aacttcacta 3414001 gtgcttttat ttcttgcaac cataatagga taccatacct tttcaacttt cgaaacctta 3414061 ttttttagat tccttaattt tacggaaaaa agacaaattc aaacaatttg cccctaaaat 3414121 cacgcatgtg gatatctttt tcggcttttt ttagtatcca cagaggttat cgacaacatt 3414181 ttcacattac caacccctgt ggacaaggtt ttttcaacag gttgtccgct ttgtggataa 3414241 gattgtgaca accattgcaa gctctcgttt attttggtat tatatttgtg ttttaactct 3414301 tgattactaa tcctaccttt cctctttatc cacaaagtgt ggataagttg tggattgatt 3414361 tcacacagct tgtgtagaag gttgtccaca agttgtgaaa tttgtcgaaa agctatttat 3414421 ctactatatt atatgttttc aacatttaat gtgtacgaat ggtaagcgcc atttgctctt 3414481 tttttgtgtt ctataacaga gaaagacgcc attttctaag aaaaggaggg acgtgccgga 3414541 ag //